Advanced analysis technique for the evaluation of linear alternators and linear motors

Science.gov (United States)

Holliday, Jeffrey C.

1995-01-01

A method for the mathematical analysis of linear alternator and linear motor devices and designs is described, and an example of its use is included. The technique seeks to surpass other methods of analysis by including more rigorous treatment of phenomena normally omitted or coarsely approximated such as eddy braking, non-linear material properties, and power losses generated within structures surrounding the device. The technique is broadly applicable to linear alternators and linear motors involving iron yoke structures and moving permanent magnets. The technique involves the application of Amperian current equivalents to the modeling of the moving permanent magnet components within a finite element formulation. The resulting steady state and transient mode field solutions can simultaneously account for the moving and static field sources within and around the device.

Dynamic Response Analysis of Linear Pulse Motor with Closed Loop Control

OpenAIRE

山本, 行雄; 山田, 一

1989-01-01

A linear pulse motor can translate digital signals into linear positions without a gear system. It is important to predict a dynamic response in order to the motor that has the good performance. In this report the maximum pulse rate and the maximum speed on the linear pulse motor are obtained by using the sampling theory.

Lithographic linear motor, lithographic apparatus, and device manufacturing method

NARCIS (Netherlands)

2006-01-01

A linear motor having a high driving force, high efficiency and low normal force comprises two opposed magnet tracks and an armature comprising three open coil sets. The linear motor may be used to drive a stage, such as, for example, a mask or wafer stage, in a lithographic apparatus.

A seismic vertical vibrator driven by linear synchronous motors

NARCIS (Netherlands)

Noorlandt, R.P.; Drijkoningen, G.G.; Dams, J.; Jenneskens, R.

2015-01-01

A linear synchronous motor (LSM) is an electric motor that can produce large controllable forces and is therefore suitable as a driving engine for a seismic vibrator. This motor consists of two independent elements, a magnet track and a coil track, allowing practically unlimited motor displacements.

The dynamic response of a linear brushless D.C. motor

Energy Technology Data Exchange (ETDEWEB)

Moghani, J.S.; Eastham, J.F. [Univ. of Bath (United Kingdom). School of Electrical and Electronic Engineering

1995-12-31

The paper describes the use of the Matlab Analogue Simulation Toolbox SIMULINK for the closed loop dynamic modeling of a linear brushless dc motor which is supplied from a delta-modulated inverter. The work is validated by experimental results taken from a large test rig. Linear version of all rotating machines are possible; a rotating machine can be notionally cut along a radial plane and unrolled to yield a linear version. The most popular form of linear machine, as judged by the quantities that have been produced is the linear induction motor. This has the advantage of first an inexpensive secondary that is often a simple iron backed conducting plate, and secondly the possibility of simple voltage control. The linear brushless synchronous motor is potentially more expensive to produce than its induction counterpart because of the permanent magnets which provide the excitation mmf and the necessity of an inverter supply. However the machine has a power factor efficiency product which can be double that of an induction motor together with about twice the tractive force per pole area.

Linear stability analysis in a solid-propellant rocket motor

Energy Technology Data Exchange (ETDEWEB)

Kim, K.M.; Kang, K.T.; Yoon, J.K. [Agency for Defense Development, Taejon (Korea, Republic of)

1995-10-01

Combustion instability in solid-propellant rocket motors depends on the balance between acoustic energy gains and losses of the system. The objective of this paper is to demonstrate the capability of the program which predicts the standard longitudinal stability using acoustic modes based on linear stability analysis and T-burner test results of propellants. Commercial ANSYS 5.0A program can be used to calculate the acoustic characteristic of a rocket motor. The linear stability prediction was compared with the static firing test results of rocket motors. (author). 11 refs., 17 figs.

A linear magnetic motor and generator

Science.gov (United States)

Studer, P. A.

1980-01-01

In linear magnetic motor and generator suitable for remote and hostile environments, magnetic forces drive reciprocating shaft along its axis. Actuator shaft is located in center of cylindrical body and may be supported by either contacting or noncontacting bearings. When device operates as bidirectional motor, drive coil selectively adds and subtracts magnetic flux to and from flux paths, producing forces that drive actuator along axis. When actuator is driven by external reciprocating engine, device becomes ac generator.

Reciprocating linear motor

Science.gov (United States)

Goldowsky, Michael P. (Inventor)

1987-01-01

A reciprocating linear motor is formed with a pair of ring-shaped permanent magnets having opposite radial polarizations, held axially apart by a nonmagnetic yoke, which serves as an axially displaceable armature assembly. A pair of annularly wound coils having axial lengths which differ from the axial lengths of the permanent magnets are serially coupled together in mutual opposition and positioned with an outer cylindrical core in axial symmetry about the armature assembly. One embodiment includes a second pair of annularly wound coils serially coupled together in mutual opposition and an inner cylindrical core positioned in axial symmetry inside the armature radially opposite to the first pair of coils. Application of a potential difference across a serial connection of the two pairs of coils creates a current flow perpendicular to the magnetic field created by the armature magnets, thereby causing limited linear displacement of the magnets relative to the coils.

Traveling-wave piezoelectric linear motor part II: experiment and performance evaluation.

Science.gov (United States)

Ting, Yung; Li, Chun-Chung; Chen, Liang-Chiang; Yang, Chieh-Min

2007-04-01

This article continues the discussion of a traveling-wave piezoelectric linear motor. Part I of this article dealt with the design and analysis of the stator of a traveling-wave piezoelectric linear motor. In this part, the discussion focuses on the structure and modeling of the contact layer and the carriage. In addition, the performance analysis and evaluation of the linear motor also are dealt with in this study. The traveling wave is created by stator, which is constructed by a series of bimorph actuators arranged in a line and connected to form a meander-line structure. Analytical and experimental results of the performance are presented and shown to be almost in agreement. Power losses due to friction and transmission are studied and found to be significant. Compared with other types of linear motors, the motor in this study is capable of supporting heavier loads and provides a larger thrust force.

Linear Parameter Varying Control of Induction Motors

DEFF Research Database (Denmark)

Trangbæk, Klaus

The subject of this thesis is the development of linear parameter varying (LPV) controllers and observers for control of induction motors. The induction motor is one of the most common machines in industrial applications. Being a highly nonlinear system, it poses challenging control problems...... for high performance applications. This thesis demonstrates how LPV control theory provides a systematic way to achieve good performance for these problems. The main contributions of this thesis are the application of the LPV control theory to induction motor control as well as various contributions...

Comparative analysis of linear motor geometries for Stirling coolers

Science.gov (United States)

R, Rajesh V.; Kuzhiveli, Biju T.

2017-12-01

Compared to rotary motor driven Stirling coolers, linear motor coolers are characterized by small volume and long life, making them more suitable for space and military applications. The motor design and operational characteristics have a direct effect on the operation of the cooler. In this perspective, ample scope exists in understanding the behavioural description of linear motor systems. In the present work, the authors compare and analyze different moving magnet linear motor geometries to finalize the most favourable one for Stirling coolers. The required axial force in the linear motors is generated by the interaction of magnetic fields of a current carrying coil and that of a permanent magnet. The compact size, commercial availability of permanent magnets and low weight requirement of the system are quite a few constraints for the design. The finite element analysis performed using Maxwell software serves as the basic tool to analyze the magnet movement, flux distribution in the air gap and the magnetic saturation levels on the core. A number of material combinations are investigated for core before finalizing the design. The effect of varying the core geometry on the flux produced in the air gap is also analyzed. The electromagnetic analysis of the motor indicates that the permanent magnet height ought to be taken in such a way that it is under the influence of electromagnetic field of current carrying coil as well as the outer core in the balanced position. This is necessary so that sufficient amount of thrust force is developed by efficient utilisation of the air gap flux density. Also, the outer core ends need to be designed to facilitate enough room for the magnet movement under the operating conditions.

A double B1-mode 4-layer laminated piezoelectric linear motor.

Science.gov (United States)

Li, Xiaotian; Chen, Zhijiang; Dong, Shuxiang

2012-12-01

We report a miniature piezoelectric ultrasonic linear motor that is made of four Pb(Zr,Ti)O(3) (PZT) piezoelectric ceramic layers for low-voltage work. The 4-layer piezoelectric laminate works in two orthogonal first-bending modes for producing elliptical oscillations, which are then used to drive a contacting slider into continuous linear motion. Experimental results show that the miniature linear motor (size: 4 × 4 × 12 mm, weight: 1.7 g) can generate a large driving force of 0.48 N and a linear motion speed of up to 160 mm/s, using a 40 V(pp)/mm voltage drive at its resonance frequency of 64.5 kHz. The maximum efficiency of the linear motor is 30%.

Motor proteins and molecular motors: how to operate machines at the nanoscale

International Nuclear Information System (INIS)

Kolomeisky, Anatoly B

2013-01-01

Several classes of biological molecules that transform chemical energy into mechanical work are known as motor proteins or molecular motors. These nanometer-sized machines operate in noisy stochastic isothermal environments, strongly supporting fundamental cellular processes such as the transfer of genetic information, transport, organization and functioning. In the past two decades motor proteins have become a subject of intense research efforts, aimed at uncovering the fundamental principles and mechanisms of molecular motor dynamics. In this review, we critically discuss recent progress in experimental and theoretical studies on motor proteins. Our focus is on analyzing fundamental concepts and ideas that have been utilized to explain the non-equilibrium nature and mechanisms of molecular motors. (topical review)

Optimization of a piezoelectric linear motor in terms of the contact parameters

International Nuclear Information System (INIS)

Ko, Hyun-Phill; Kim, Sangsig; Kang, Chong-Yun; Kim, Hyun-Jai; Yoon, Seok-Jin

2005-01-01

The contact kinetics of piezoelectric linear motors determines the operational characteristics like speed and torque or transmitted mechanical power and efficiency. Piezoelectric linear motors are driven by tangential stress in the interface between tip of shaking beam and slider. A good contact between the tip and slider is necessary for a reliable analysis of the motor, which is needed for the optimization of its performance. The piezoelectric linear motor was fabricated and the characteristics of the motor were investigated by external conditions such as tip shape with different curvatures and contact force between the tip and the slider. It was found in this investigation that the optimal curvature of the tip and the contact force are curvature of 1 and 10, respectively, for the high actuating speed, and curvature of 1 and 40 N, respectively, for the high actuating force. Finally, tip shape has an influence on the characteristics of linear motor

Study of linear induction motor characteristics : the Mosebach model

Science.gov (United States)

1976-05-31

This report covers the Mosebach theory of the double-sided linear induction motor, starting with the ideallized model and accompanying assumptions, and ending with relations for thrust, airgap power, and motor efficiency. Solutions of the magnetic in...

Study of linear induction motor characteristics : the Oberretl model

Science.gov (United States)

1975-05-30

The Oberretl theory of the double-sided linear induction motor (LIM) is examined, starting with the idealized model and accompanying assumptions, and ending with relations for predicted thrust, airgap power, and motor efficiency. The effect of varyin...

Impact self-excited vibrations of linear motor

Science.gov (United States)

Zhuravlev, V. Ph.

2010-08-01

Impact self-exciting vibration modes in a linear motor of a monorail car are studied. Existence and stability conditions of self-exciting vibrations are found. Ways of avoiding the vibrations are discussed.

A square-plate ultrasonic linear motor operating in two orthogonal first bending modes.

Science.gov (United States)

Chen, Zhijiang; Li, Xiaotian; Chen, Jianguo; Dong, Shuxiang

2013-01-01

A novel square-plate piezoelectric ultrasonic linear motor operated in two orthogonal first bending vibration modes (B₁) is proposed. The piezoelectric vibrator of the linear motor is simply made of a single PZT ceramic plate (sizes: 15 x 15 x 2 mm) and poled in its thickness direction. The top surface electrode of the square ceramic plate was divided into four active areas along its two diagonal lines for exciting two orthogonal B₁ modes. The achieved driving force and speed from the linear motor are 1.8 N and 230 mm/s, respectively, under one pair orthogonal voltage drive of 150 V(p-p) at the resonance frequency of 92 kHz. The proposed linear motor has advantages over conventional ultrasonic linear motors, such as relatively larger driving force, very simple working mode and structure, and low fabrication cost.

Modelling a linear PM motor including magnetic saturation

NARCIS (Netherlands)

Polinder, H.; Slootweg, J.G.; Compter, J.C.; Hoeijmakers, M.J.

2002-01-01

The use of linear permanent-magnet (PM) actuators increases in a wide variety of applications because of the high force density, robustness and accuracy. The paper describes the modelling of a linear PM motor applied in, for example, wafer steppers, including magnetic saturation. This is important

Linear summation of outputs in a balanced network model of motor cortex.

Science.gov (United States)

Capaday, Charles; van Vreeswijk, Carl

2015-01-01

Given the non-linearities of the neural circuitry's elements, we would expect cortical circuits to respond non-linearly when activated. Surprisingly, when two points in the motor cortex are activated simultaneously, the EMG responses are the linear sum of the responses evoked by each of the points activated separately. Additionally, the corticospinal transfer function is close to linear, implying that the synaptic interactions in motor cortex must be effectively linear. To account for this, here we develop a model of motor cortex composed of multiple interconnected points, each comprised of reciprocally connected excitatory and inhibitory neurons. We show how non-linearities in neuronal transfer functions are eschewed by strong synaptic interactions within each point. Consequently, the simultaneous activation of multiple points results in a linear summation of their respective outputs. We also consider the effects of reduction of inhibition at a cortical point when one or more surrounding points are active. The network response in this condition is linear over an approximately two- to three-fold decrease of inhibitory feedback strength. This result supports the idea that focal disinhibition allows linear coupling of motor cortical points to generate movement related muscle activation patterns; albeit with a limitation on gain control. The model also explains why neural activity does not spread as far out as the axonal connectivity allows, whilst also explaining why distant cortical points can be, nonetheless, functionally coupled by focal disinhibition. Finally, we discuss the advantages that linear interactions at the cortical level afford to motor command synthesis.

Comparison of linear synchronous and induction motors

Science.gov (United States)

2004-06-01

A propulsion prade study was conducted as part of the Colorado Maglev Project of FTA's Urban Maglev Technology Development Program to identify and evaluate prospective linear motor designs that could potentially meet the system performance requiremen...

Design and performance testing of an ultrasonic linear motor with dual piezoelectric actuators.

Science.gov (United States)

Smithmaitrie, Pruittikorn; Suybangdum, Panumas; Laoratanakul, Pitak; Muensit, Nantakan

2012-05-01

In this work, design and performance testing of an ultrasonic linear motor with dual piezoelectric actuator patches are studied. The motor system consists of a linear stator, a pre-load weight, and two piezoelectric actuator patches. The piezoelectric actuators are bonded with the linear elastic stator at specific locations. The stator generates propagating waves when the piezoelectric actuators are subjected to harmonic excitations. Vibration characteristics of the linear stator are analyzed and compared with finite element and experimental results. The analytical, finite element, and experimental results show agreement. In the experiments, performance of the ultrasonic linear motor is tested. Relationships between velocity and pre-load weight, velocity and applied voltage, driving force and applied voltage, and velocity and driving force are reported. The design of the dual piezoelectric actuators yields a simpler structure with a smaller number of actuators and lower stator stiffness compared with a conventional design of an ultrasonic linear motor with fully laminated piezoelectric actuators.

Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry

International Nuclear Information System (INIS)

Zuckermann, Martin J; Forde, Nancy R; Angstmann, Christopher N; Schmitt, Regina; Linke, Heiner; Blab, Gerhard A; Bromley, Elizabeth HC; Curmi, Paul MG

2015-01-01

The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency of ∼18%, comparable to that of kinesin. In principle, the walker can be turned into a permanent motor by externally monitoring the walker’s momentary direction of motion, and using feedback to adjust the direction of a load force. We calculate the thermodynamic cost of using feedback to enhance motor performance in terms of the Shannon entropy, and find that it reduces the efficiency of a realistic motor only marginally. We discuss the implications for natural protein motor performance in the context of the strong performance of this design based only on a thermal ratchet. (paper)

Entropic potential field formed for a linear-motor protein near a filament: Statistical-mechanical analyses using simple models.

Science.gov (United States)

Amano, Ken-Ichi; Yoshidome, Takashi; Iwaki, Mitsuhiro; Suzuki, Makoto; Kinoshita, Masahiro

2010-07-28

We report a new progress in elucidating the mechanism of the unidirectional movement of a linear-motor protein (e.g., myosin) along a filament (e.g., F-actin). The basic concept emphasized here is that a potential field is entropically formed for the protein on the filament immersed in solvent due to the effect of the translational displacement of solvent molecules. The entropic potential field is strongly dependent on geometric features of the protein and the filament, their overall shapes as well as details of the polyatomic structures. The features and the corresponding field are judiciously adjusted by the binding of adenosine triphosphate (ATP) to the protein, hydrolysis of ATP into adenosine diphosphate (ADP)+Pi, and release of Pi and ADP. As the first step, we propose the following physical picture: The potential field formed along the filament for the protein without the binding of ATP or ADP+Pi to it is largely different from that for the protein with the binding, and the directed movement is realized by repeated switches from one of the fields to the other. To illustrate the picture, we analyze the spatial distribution of the entropic potential between a large solute and a large body using the three-dimensional integral equation theory. The solute is modeled as a large hard sphere. Two model filaments are considered as the body: model 1 is a set of one-dimensionally connected large hard spheres and model 2 is a double helical structure formed by two sets of connected large hard spheres. The solute and the filament are immersed in small hard spheres forming the solvent. The major findings are as follows. The solute is strongly confined within a narrow space in contact with the filament. Within the space there are locations with sharply deep local potential minima along the filament, and the distance between two adjacent locations is equal to the diameter of the large spheres constituting the filament. The potential minima form a ringlike domain in model 1

Analysis of Nonlinear Dynamics in Linear Compressors Driven by Linear Motors

Science.gov (United States)

Chen, Liangyuan

2018-03-01

The analysis of dynamic characteristics of the mechatronics system is of great significance for the linear motor design and control. Steady-state nonlinear response characteristics of a linear compressor are investigated theoretically based on the linearized and nonlinear models. First, the influence factors considering the nonlinear gas force load were analyzed. Then, a simple linearized model was set up to analyze the influence on the stroke and resonance frequency. Finally, the nonlinear model was set up to analyze the effects of piston mass, spring stiffness, driving force as an example of design parameter variation. The simulating results show that the stroke can be obtained by adjusting the excitation amplitude, frequency and other adjustments, the equilibrium position can be adjusted by adjusting the DC input, and to make the more efficient operation, the operating frequency must always equal to the resonance frequency.

Development of a sub-nanometer positioning device: combining a new linear motor with linear motion ball guide ways

International Nuclear Information System (INIS)

Otsuka, J; Tanaka, T; Masuda, I

2010-01-01

A new type of linear motor described in this note has some advantages compared with conventional motors. The attractive magnetic force between the stator (permanent magnets) and mover (armature) is diminished almost to zero. The efficiency is better because the magnetic flux leakage is very small, the size of motor is smaller and detent (force ripple) is smaller than for conventional motors. Therefore, we think that this motor is greatly suitable for ultra-precision positioning as an actuator. An ultra-precision positioning device using this motor and linear motion ball guide ways is newly developed by making the device very rigid and using a suitable control method. Moreover, the positioning performance is evaluated by a positioning resolution, and deviation and dispersion errors. As a result of repeated step response tests, the positioning resolution is 0.3 nm, with the deviation error and dispersion error (3σ) being sub-nanometer. Consequently, the positioning device achieves sub-nanometer positioning. (technical design note)

Magnetic levitation configuration incorporating levitation, guidance and linear synchronous motor

Science.gov (United States)

Coffey, Howard T.

1993-01-01

A propulsion and suspension system for an inductive repulsion type magnetically levitated vehicle which is propelled and suspended by a system which includes propulsion windings which form a linear synchronous motor and conductive guideways, adjacent to the propulsion windings, where both combine to partially encircling the vehicle-borne superconducting magnets. A three phase power source is used with the linear synchronous motor to produce a traveling magnetic wave which in conjunction with the magnets propel the vehicle. The conductive guideway combines with the superconducting magnets to provide for vehicle leviation.

Magnetic levitation configuration incorporating levitation, guidance and linear synchronous motor

Science.gov (United States)

Coffey, H.T.

1993-10-19

A propulsion and suspension system for an inductive repulsion type magnetically levitated vehicle which is propelled and suspended by a system which includes propulsion windings which form a linear synchronous motor and conductive guideways, adjacent to the propulsion windings, where both combine to partially encircling the vehicle-borne superconducting magnets. A three phase power source is used with the linear synchronous motor to produce a traveling magnetic wave which in conjunction with the magnets propel the vehicle. The conductive guideway combines with the superconducting magnets to provide for vehicle levitation. 3 figures.

Modeling and analysis of mover gaps in tubular moving-magnet linear oscillating motors

Directory of Open Access Journals (Sweden)

Xuesong LUO

2018-05-01

Full Text Available A tubular moving-magnet linear oscillating motor (TMMLOM has merits of high efficiency and excellent dynamic capability. To enhance the thrust performance, quasi-Halbach permanent magnet (PM arrays are arranged on its mover in the application of a linear electro-hydrostatic actuator in more electric aircraft. The arrays are assembled by several individual segments, which lead to gaps between them inevitably. To investigate the effects of the gaps on the radial magnetic flux density and the machine thrust in this paper, an analytical model is built considering both axial and radial gaps. The model is validated by finite element simulations and experimental results. Distributions of the magnetic flux are described in condition of different sizes of radial and axial gaps. Besides, the output force is also discussed in normal and end windings. Finally, the model has demonstrated that both kinds of gaps have a negative effect on the thrust, and the linear motor is more sensitive to radial ones. Keywords: Air-gap flux density, Linear motor, Mover gaps, Quasi-Halbach array, Thrust output, Tubular moving-magnet linear oscillating motor (TMMLOM

A Study on the Design of PM Exited Transverse Flux Linear Motor for Ropeless Elevator

Energy Technology Data Exchange (ETDEWEB)

Kang, Do Hyun; Bang, Deok Je; Kim, Jong Moo; Jeong, Yeon Ho [Korea Electrotechnology Research Institute (Korea); Kim, Moon Hwan [Silla University (Korea)

2000-03-01

The topological investigations regarding magnetic circuit geometry and winding form of the transverse flux machine have brought up a variety of constructable arrangements with different features for several types of application[1, 2]. Here with, a novel PM-exited linear motor with inner mover, based on the transverse flux configuration leads to a considerable increase in power density for moving part. In this study we designed PM-exited transverse flux linear motor for ropeless elevator, whose output power density is higher and weight is lighter than conventional linear synchronous motors, When the designed motor in this study is applied to ropeless elevator, it is possible to increase power density more than 400% comparing with PM exited linear synchronous motor. The result of this study can be utilized for ropeless elevator or gearless direct linear moving system with high output[3]. (author). 8 refs., 9 figs., 4 tabs.

A beam scraper using a linear motor

International Nuclear Information System (INIS)

Beadle, E.R.; Rodger, E.S.; Thern, R.E.

1989-01-01

A beam scraper using a linear motor drive has been developed for use in the AGS at Brookhaven National Laboratory. The device is used to measure beam size by moving a target to a predetermined location and measuring the intercepted beam with nearby loss monitors or by noting the decrease in the circulating beam current. This device has excellent vacuum characteristics, as the motor and sensor coils are outside the vacuum, coupled magnetically to the moving parts which, are inside. There are no bellows or dynamic seals required. The position-time profile is controlled by a closed-loop servo system which uses position feedback. 2 refs., 4 figs

Electromagnetic Energy Converters - Rotating Motors and Linear Generators

Energy Technology Data Exchange (ETDEWEB)

Ekergaard, Boel

2011-07-01

This licentiate thesis presents a study of the electromagnetic properties of linear synchronous permanent magnet generators, utilized in wave energy converters, and a two pole permanent magnet motor for an electrical vehicle. Both machine topologies are presented, designed with a numerical simulation tool, based on a model derived from Maxwell's equations. Full scale prototypes of both the machines are under construction. A continued study about the impact on the magnetic circuit caused by the longitudinal ends of a linear generator is performed. The results present significant core losses in the translator and an increased cogging force caused by the longitudinal ends. Further, a new electric conversion circuit based on the electric resonance phenomena is presented. Experimental results indicate that a successful electric resonance between the generator and external circuit has been achieved. Finally, detailed analytical and numerical methods are utilized to investigate the losses in the two pole permanent magnet motor over a wide frequency interval. The results indicate that the efficiency of electrical motors in electrical vehicle system can be increased relative existing designs and argue for limiting of the gearbox. The system total efficiency and mechanical stability can thereby be increased. The work concerning the wave energy converter is a part of a larger project, the so called Lysekil Wave Power Project, whereas the work concerning the electric motor so far has been carried out as an individual project. However, a future goal is to integrate the research on the electric motor for electrical vehicle with closely related ongoing research regarding a flywheel based electric driveline for an All Electric Propulsion System

Study on a high thrust force bi-double-sided permanent magnet linear synchronous motor

Directory of Open Access Journals (Sweden)

Liang Tong

2016-03-01

Full Text Available A high thrust force bi-double-sided permanent magnet linear synchronous motor used in gantry-type five-axis machining center is designed and its performance was tested in this article. This motor is the subproject of Chinese National Science and Technology Major Project named as “development of domestic large thrust linear motor used in high-speed gantry-type five-axis machining center project” jointly participated by enterprises and universities. According to the requirement of the application environment and motor performance parameters, the linear motor’s basic dimensions, form of windings, and magnet arrangement are preliminarily specified through theoretical analysis and calculation. To verify the correctness of the result of the calculation, the finite element model of the motor is established. The static and dynamic characteristics of the motor are studied and analyzed through the finite element method, and the initial scheme is revised. The prototype of the motor is manufactured based on the final revised structure parameters, and the performance of the motor is fully tested using the evaluation platform for direct-drive motor component. Experimental test results meet the design requirements and show the effectiveness of design method and process.

Contact analysis and experimental investigation of a linear ultrasonic motor.

Science.gov (United States)

Lv, Qibao; Yao, Zhiyuan; Li, Xiang

2017-11-01

The effects of surface roughness are not considered in the traditional motor model which fails to reflect the actual contact mechanism between the stator and slider. An analytical model for calculating the tangential force of linear ultrasonic motor is proposed in this article. The presented model differs from the previous spring contact model, the asperities in contact between stator and slider are considered. The influences of preload and exciting voltage on tangential force in moving direction are analyzed. An experiment is performed to verify the feasibility of this proposed model by comparing the simulation results with the measured data. Moreover, the proposed model and spring model are compared. The results reveal that the proposed model is more accurate than spring model. The discussion is helpful for designing and modeling of linear ultrasonic motors. Copyright © 2017 Elsevier B.V. All rights reserved.

MAGNETIC INDUCTION DISTRIBUTION IN A LINEAR SYNCHRONUS MOTOR WITH MAGNETIC SUSPENSION

Directory of Open Access Journals (Sweden)

D.I. Parkhomenko

2013-02-01

Full Text Available Results of computer simulation and experimental investigations of magnetic induction distribution in a coaxial linear synchronous motor with magnetic suspension are presented. The magnetic induction distribution has been studied both in the motor air gap and on the runner surface.

Direct torque control via feedback linearization for permanent magnet synchronous motor drives

DEFF Research Database (Denmark)

Lascu, Cristian; Boldea, Ion; Blaabjerg, Frede

2012-01-01

The paper describes a direct torque controlled (DTC) permanent magnet synchronous motor (PMSM) drive that employs feedback linearization and uses sliding-mode and linear controllers. We introduce a new feedback linearization approach that yields a decoupled linear PMSM model with two state...

A standing wave linear ultrasonic motor operating in in-plane expanding and bending modes.

Science.gov (United States)

Chen, Zhijiang; Li, Xiaotian; Ci, Penghong; Liu, Guoxi; Dong, Shuxiang

2015-03-01

A novel standing wave linear ultrasonic motor operating in in-plane expanding and bending modes was proposed in this study. The stator (or actuator) of the linear motor was made of a simple single Lead Zirconate Titanate (PZT) ceramic square plate (15 × 15 × 2 mm(3)) with a circular hole (D = 6.7 mm) in the center. The geometric parameters of the stator were computed with the finite element analysis to produce in-plane bi-mode standing wave vibration. The calculated results predicted that a driving tip attached at midpoint of one edge of the stator can produce two orthogonal, approximate straight-line trajectories, which can be used to move a slider in linear motion via frictional forces in forward or reverse direction. The investigations showed that the proposed linear motor can produce a six times higher power density than that of a previously reported square plate motor.

Magnetic shielding for coreless linear permanent magnet motors

NARCIS (Netherlands)

Pluk, K.J.W.; Jansen, J.W.; Lomonova, E.

2013-01-01

This paper concerns the local reduction of the magnetic flux density by means of magnetic shielding. Using a spatial frequency description, a 2-D semi-analytical periodic model is obtained for a coreless single-sided linear permanent magnet motor. The magnetic shield is included in the modeling

Cortical Contribution to Linear, Non-linear and Frequency Components of Motor Variability Control during Standing.

Science.gov (United States)

König Ignasiak, Niklas; Habermacher, Lars; Taylor, William R; Singh, Navrag B

2017-01-01

Motor variability is an inherent feature of all human movements and reflects the quality of functional task performance. Depending on the requirements of the motor task, the human sensory-motor system is thought to be able to flexibly govern the appropriate level of variability. However, it remains unclear which neurophysiological structures are responsible for the control of motor variability. In this study, we tested the contribution of cortical cognitive resources on the control of motor variability (in this case postural sway) using a dual-task paradigm and furthermore observed potential changes in control strategy by evaluating Ia-afferent integration (H-reflex). Twenty healthy subjects were instructed to stand relaxed on a force plate with eyes open and closed, as well as while trying to minimize sway magnitude and performing a "subtracting-sevens" cognitive task. In total 25 linear and non-linear parameters were used to evaluate postural sway, which were combined using a Principal Components procedure. Neurophysiological response of Ia-afferent reflex loop was quantified using the Hoffman reflex. In order to assess the contribution of the H-reflex on the sway outcome in the different standing conditions multiple mixed-model ANCOVAs were performed. The results suggest that subjects were unable to further minimize their sway, despite actively focusing to do so. The dual-task had a destabilizing effect on PS, which could partly (by 4%) be counter-balanced by increasing reliance on Ia-afferent information. The effect of the dual-task was larger than the protective mechanism of increasing Ia-afferent information. We, therefore, conclude that cortical structures, as compared to peripheral reflex loops, play a dominant role in the control of motor variability.

Stepping motor adaptor actuator for a commercial uhv linear motion feedthrough

International Nuclear Information System (INIS)

Iarocci, M.; Oversluizen, T.

1989-01-01

An adaptor coupling has been developed that will allow the attachment of a standard stepping motor to a precision commercial (Varian) uhv linear motion feedthrough. The assembly, consisting of the motor, motor adaptor, limit switches, etc. is clamped to the feedthrough body which can be done under vacuum conditions if necessary. With a 500 step/rev. stepping motor the resolution is 1.27 μm per step. We presently use this assembly in a remote location for the precise positioning of a beam sensing monitor. 2 refs., 3 figs

Life without double-headed non-muscle myosin II motor proteins

Science.gov (United States)

Betapudi, Venkaiah

2014-07-01

Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC) belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has given a single myosin II motor protein for lower eukaryotes and multiple for mammals but none for plants in order to provide impetus for their life. These specialized nanomachines drive cellular activities necessary for embryogenesis, organogenesis, and immunity. However, these multifunctional myosin II motor proteins are believed to go awry due to unknown reasons and contribute for the onset and progression of many autosomal-dominant disorders, cataract, deafness, infertility, cancer, kidney, neuronal, and inflammatory diseases. Many pathogens like HIV, Dengue, hepatitis C, and Lymphoma viruses as well as Salmonella and Mycobacteria are now known to take hostage of these dedicated myosin II motor proteins for their efficient pathogenesis. Even after four decades since their discovery, we still have a limited knowledge of how these motor proteins drive cell migration and cytokinesis. We need to enrich our current knowledge on these fundamental cellular processes and develop novel therapeutic strategies to fix mutated myosin II motor proteins in pathological conditions. This is the time to think how to relieve the hijacked myosins from pathogens in order to provide a renewed impetus for patients’ life. Understanding how to steer these molecular motors in proliferating and differentiating stem cells will improve stem cell based-therapeutics development. Given the plethora of cellular activities non-muscle myosin motor proteins are involved in, their importance is apparent for human life.

Life without double-headed non-muscle myosin II motor proteins

Directory of Open Access Journals (Sweden)

Venkaiah eBetapudi

2014-07-01

Full Text Available Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has given a single myosin II motor protein for lower eukaryotes and multiple for mammals but none for plants in order to provide impetus for their life. These specialized nanomachines drive cellular activities necessary for embryogenesis, organogenesis, and immunity. However, these multifunctional myosin II motor proteins are believed to go awry due to unknown reasons and contribute for the onset and progression of many autosomal-dominant disorders, cataract, deafness, infertility, cancer, kidney, neuronal, and inflammatory diseases. Many pathogens like HIV, Dengue, hepatitis C, and Lymphoma viruses as well as Salmonella and Mycobacteria are now known to take hostage of these dedicated myosin II motor proteins for their efficient pathogenesis. Even after four decades since their discovery, we still have a limited knowledge of how these motor proteins drive cell migration and cytokinesis. We need to enrich our current knowledge on these fundamental cellular processes and develop novel therapeutic strategies to fix mutated myosin II motor proteins in pathological conditions. This is the time to think how to relieve the hijacked myosins from pathogens in order to provide a renewed impetus for patients’ life. Understanding how to steer these molecular motors in proliferating and differentiating stem cells will improve stem cell based-therapeutics development. Given the plethora of cellular activities non-muscle myosin motor proteins are involved in, their importance is apparent for human life.

Mathematical models of flat linear induction motors used in mining drives

Energy Technology Data Exchange (ETDEWEB)

Tall, M

1984-01-01

Design parameters are calculated for electric flat linear induction motors, widely employed in the coal and ore mining industries in Poland. A mathematical model of this motor with a single-layer ferromagnetic secondary part is presented. A three-dimensional electromagnetic field analysis is carried out, taking relative magnetic permeability variation, discrete winding distribution, influence of armature grooving and pulsating field influence into account. A computer calculation algorithm is proposed for determining motor characteristics. 17 refs.

Unmasking the linear behaviour of slow motor adaptation to prolonged convergence.

Science.gov (United States)

Erkelens, Ian M; Thompson, Benjamin; Bobier, William R

2016-06-01

Adaptation to changing environmental demands is central to maintaining optimal motor system function. Current theories suggest that adaptation in both the skeletal-motor and oculomotor systems involves a combination of fast (reflexive) and slow (recalibration) mechanisms. Here we used the oculomotor vergence system as a model to investigate the mechanisms underlying slow motor adaptation. Unlike reaching with the upper limbs, vergence is less susceptible to changes in cognitive strategy that can affect the behaviour of motor adaptation. We tested the hypothesis that mechanisms of slow motor adaptation reflect early neural processing by assessing the linearity of adaptive responses over a large range of stimuli. Using varied disparity stimuli in conflict with accommodation, the slow adaptation of tonic vergence was found to exhibit a linear response whereby the rate (R(2)  = 0.85, P < 0.0001) and amplitude (R(2)  = 0.65, P < 0.0001) of the adaptive effects increased proportionally with stimulus amplitude. These results suggest that this slow adaptive mechanism is an early neural process, implying a fundamental physiological nature that is potentially dominated by subcortical and cerebellar substrates. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Development of a linear induction motor based artificial muscle system.

Science.gov (United States)

Gruber, A; Arguello, E; Silva, R

2013-01-01

We present the design of a linear induction motor based on electromagnetic interactions. The engine is capable of producing a linear movement from electricity. The design consists of stators arranged in parallel, which produce a magnetic field sufficient to displace a plunger along its axial axis. Furthermore, the winding has a shell and cap of ferromagnetic material that amplifies the magnetic field. This produces a force along the length of the motor that is similar to that of skeletal muscle. In principle, the objective is to use the engine in the development of an artificial muscle system for prosthetic applications, but it could have multiple applications, not only in the medical field, but in other industries.

Principle and analysis of a linear motor driving system for HTS levitation applications

International Nuclear Information System (INIS)

Jin, Jian X.; Guo, You G.; Zhu, Jian G.

2007-01-01

High temperature superconductor (HTS) high levitation force density with passive and self-stabilizing features allows a number of special applications to be developed. Linear motor driving systems are commonly required for those applications such as levitated transport systems. In this paper a prototype linear motor driving system with HTS is analyzed with calculation details including its magnetic fields and driving forces presented in the paper

Design of linear pulse motor for control element drive mechanism of SMART

International Nuclear Information System (INIS)

Kim, J. H.; Huh, H.; Kim, J. I.; Jang, M. H.; Kang, D. H.

1999-01-01

49 Control Rod Drive Mechanisms(CEDMs) are densely installed on the reactor central head of SMART. The structural design should ensure the space for maintenance/repair, cable routing, and heat release from the motor. In this paper, an improved design is presented to enlarge the space between CEDMs by decreasing the diameter of linear pulse motor. The reduction of motor thrust force due to the decrease of the motor diameter is compensated by resizing the other structural components

Linear Motor Motion Control Experiment System Design Based on LabVIEW

Directory of Open Access Journals (Sweden)

Cuixian He

2018-01-01

Full Text Available In order to meet the needs of experimental training of electrical information industry, a linear motor motion experiment system based on LabVIEW was developed. This system is based on the STM32F103ZET6 system processor controller, a state signal when the motor moves through the grating encoder feedback controller to form a closed loop, through the RS232 serial port communication with the host computer, the host computer is designed in the LabVIEW interactive environment monitoring software. Combined with the modular design concept proposed overall program, given the detailed hardware circuit, targeted for the software function design, to achieve man-machine interface. The system control of high accuracy, good stability, meet the training requirements for laboratory equipment, but also as a reference embodiment of the linear motor monitoring system.

Evaluation of linear induction motor characteristics : the Yamamura model

Science.gov (United States)

1975-04-30

The Yamamura theory of the double-sided linear induction motor (LIM) excited by a constant current source is discussed in some detail. The report begins with a derivation of thrust and airgap power using the method of vector potentials and theorem of...

Analysis and Design of Double-sided Air core Linear Servo Motor with Trapezoidal Permanent Magnets

DEFF Research Database (Denmark)

Zhang, Yuqiu; Yang, Zilong; Yu, Minghu

2011-01-01

In order to reduce the thrust ripple of linear servo system, a double-sided air core permanent magnet linear servo motor with trapezoidal shape permanent magnets (TDAPMLSM) is proposed in this paper. An analytical model of the motor for predicting the magnetic field in the air-gap at no...

Thermally driven molecular linear motors - A molecular dynamics study

DEFF Research Database (Denmark)

Zambrano, Harvey A; Walther, Jens Honore; Jaffe, Richard Lawrence

2009-01-01

We conduct molecular dynamics simulations of a molecular linear motor consisting of coaxial carbon nanotubes with a long outer carbon nanotube confining and guiding the motion of an inner short, capsule-like nanotube. The simulations indicate that the motion of the capsule can be controlled by th...

Commercializing a U.S. piezoceramic linear motor

Science.gov (United States)

Diehl, Rick W.

2000-06-01

A small low-cost piezoceramic linear motor has been developed in the US and is being commercialized by EDO Corporation, working with a leading motion control OEM and with a prominent US corporate research laboratory. First generation motor design has emphasized high displacement at up to 200mm per second velocity with 3.5 Newtons force with high resolution, short time constant and a 15 volt power supply at a cost of less than 100 dollars. Motor dimensions of 30 by 50 by 4 mm allow broad configuration choices, al hidden within the motion control slide. The EDO approach was to build on its core competence in high reliability electroceramic material engineering and production, and to use a strategy of back-integrating, or outsourcing of recent advances outside Edo in piezoceramics, while forward- integrating into specific emerging applications known intimately by the OEM in the market. The strategy provided design focus that has led to a cost-effective advance in 'solid-state actuation and control'. This is considered a classic case of successful industrial integration of an enabling technology across organizations in order to access the needed mix of technology for development of an innovative and competitive solution.

Direct Torque Control With Feedback Linearization for Induction Motor Drives

DEFF Research Database (Denmark)

Lascu, Cristian; Jafarzadeh, Saeed; Fadali, Sami M.

2017-01-01

This paper describes a direct-torque-controlled (DTC) induction motor (IM) drive that employs feedback linearization and sliding-mode control (SMC). A new feedback linearization approach is proposed, which yields a decoupled linear IM model with two state variables: torque and stator flux magnitude....... This intuitive linear model is used to implement a DTC-type controller that preserves all DTC advantages and eliminates its main drawback, the flux and torque ripple. Robust, fast, and ripple-free control is achieved by using SMC with proportional control in the vicinity of the sliding surface. SMC assures...... in simulations. The sliding controller is compared with a linear DTC scheme with and without feedback linearization. Extensive experimental results for a sensorless IM drive validate the proposed solution....

Design optimization of a linear permanent magnet synchronous motor for extra low force pulsations

International Nuclear Information System (INIS)

Isfahani, Aarsh Hassanpour; Vaez-Zadeh, Sadegh

2007-01-01

Air cored linear permanent magnet synchronous motors have essentially low force pulsations due to the lack of the primary iron core and teeth. However, a motor design with much lower force pulsations is required for many precise positioning systems, as in fabrication of microelectronic chips. This paper presents the design optimization of an air cored linear permanent magnet synchronous motor with extra low force pulsations for such applications. In order to achieve the goal, an analytical layer model of the machine is developed. A very effective objective function regarding force pulsations is then proposed; while the selected motor dimensions are regarded as the design variables. A genetic algorithm is used to find the optimal motor dimensions. This results in a substantial ninety percent reduction in the force pulsations. The design optimization is verified by a finite element method

International program on linear electric motors. CIGGT report No. 92-1

Energy Technology Data Exchange (ETDEWEB)

Dawson, G.E.; Eastham, A.R.; Parker, J.H.

1992-12-31

The International Program for Linear Electric Motors (LEM) was begun in April 1989 to communicate and coordinate activities with centers of expertise in Germany, Canada, and Japan; to provide for the assessment and support of the planning of technological developments and for dissemination of information to researchers, service operators, and policy makers; and to ensure that full advantage can be taken if opportunities for technology transfer occur. This report documents the work done under the program, including standardizing linear induction motor (LIM) design characteristics; test procedures and measurement methods; rating; database for design data; criteria for evaluation of designs; computer programs for modelling performance; and a design study for an agreed application.

Universal Linear Motor Driven Leg Press Dynamometer and Concept of Serial Stretch Loading.

Science.gov (United States)

Hamar, Dušan

2015-08-24

Paper deals with backgrounds and principles of universal linear motor driven leg press dynamometer and concept of serial stretch loading. The device is based on two computer controlled linear motors mounted to the horizontal rails. As the motors can keep either constant resistance force in selected position or velocity in both directions, the system allows simulation of any mode of muscle contraction. In addition, it also can generate defined serial stretch stimuli in a form of repeated force peaks. This is achieved by short segments of reversed velocity (in concentric phase) or acceleration (in eccentric phase). Such stimuli, generated at the rate of 10 Hz, have proven to be a more efficient means for the improvement of rate of the force development. This capability not only affects performance in many sports, but also plays a substantial role in prevention of falls and their consequences. Universal linear motor driven and computer controlled dynamometer with its unique feature to generate serial stretch stimuli seems to be an efficient and useful tool for enhancing strength training effects on neuromuscular function not only in athletes, but as well as in senior population and rehabilitation patients.

Probing intracellular motor protein activity using an inducible cargo trafficking assay

NARCIS (Netherlands)

L.C. Kapitein (Lukas); M.A. Schlager (Max); W.A. van der Zwan (Wouter); P. Wulf (Phebe); N. Keijzer (Nanda); C.C. Hoogenraad (Casper)

2010-01-01

textabstractAlthough purified cytoskeletal motor proteins have been studied extensively with the use of in vitro approaches, a generic approach to selectively probe actin and microtubule-based motor protein activity inside living cells is lacking. To examine specific motor activity inside living

Linear pneumatic motors – a comparative study

Directory of Open Access Journals (Sweden)

Deaconescu Tudor

2017-01-01

Full Text Available The paper presents a comparative study of the performance of single-acting cylinders, diaphragm cylinders and pneumatic muscles, and offers users information that allows the selection of an optimum technical solution. Such a study was necessary, in view of the numerous papers on pneumatic muscle applications found in literature, that assert the superiority of pneumatic muscles over other pneumatic linear motors in relation to quantities like dimensions, mass, developed force or energy-to-mass ratios, however without offering concrete data.

Multiscale modeling and simulation of microtubule–motor-protein assemblies

Science.gov (United States)

Gao, Tong; Blackwell, Robert; Glaser, Matthew A.; Betterton, M. D.; Shelley, Michael J.

2016-01-01

Microtubules and motor proteins self-organize into biologically important assemblies including the mitotic spindle and the centrosomal microtubule array. Outside of cells, microtubule-motor mixtures can form novel active liquid-crystalline materials driven out of equilibrium by adenosine triphosphate–consuming motor proteins. Microscopic motor activity causes polarity-dependent interactions between motor proteins and microtubules, but how these interactions yield larger-scale dynamical behavior such as complex flows and defect dynamics is not well understood. We develop a multiscale theory for microtubule-motor systems in which Brownian dynamics simulations of polar microtubules driven by motors are used to study microscopic organization and stresses created by motor-mediated microtubule interactions. We identify polarity-sorting and crosslink tether relaxation as two polar-specific sources of active destabilizing stress. We then develop a continuum Doi-Onsager model that captures polarity sorting and the hydrodynamic flows generated by these polar-specific active stresses. In simulations of active nematic flows on immersed surfaces, the active stresses drive turbulent flow dynamics and continuous generation and annihilation of disclination defects. The dynamics follow from two instabilities, and accounting for the immersed nature of the experiment yields unambiguous characteristic length and time scales. When turning off the hydrodynamics in the Doi-Onsager model, we capture formation of polar lanes as observed in the Brownian dynamics simulation. PMID:26764729

Multiscale modeling and simulation of microtubule-motor-protein assemblies.

Science.gov (United States)

Gao, Tong; Blackwell, Robert; Glaser, Matthew A; Betterton, M D; Shelley, Michael J

2015-01-01

Microtubules and motor proteins self-organize into biologically important assemblies including the mitotic spindle and the centrosomal microtubule array. Outside of cells, microtubule-motor mixtures can form novel active liquid-crystalline materials driven out of equilibrium by adenosine triphosphate-consuming motor proteins. Microscopic motor activity causes polarity-dependent interactions between motor proteins and microtubules, but how these interactions yield larger-scale dynamical behavior such as complex flows and defect dynamics is not well understood. We develop a multiscale theory for microtubule-motor systems in which Brownian dynamics simulations of polar microtubules driven by motors are used to study microscopic organization and stresses created by motor-mediated microtubule interactions. We identify polarity-sorting and crosslink tether relaxation as two polar-specific sources of active destabilizing stress. We then develop a continuum Doi-Onsager model that captures polarity sorting and the hydrodynamic flows generated by these polar-specific active stresses. In simulations of active nematic flows on immersed surfaces, the active stresses drive turbulent flow dynamics and continuous generation and annihilation of disclination defects. The dynamics follow from two instabilities, and accounting for the immersed nature of the experiment yields unambiguous characteristic length and time scales. When turning off the hydrodynamics in the Doi-Onsager model, we capture formation of polar lanes as observed in the Brownian dynamics simulation.

Multiscale modeling and simulation of microtubule-motor-protein assemblies

Science.gov (United States)

Gao, Tong; Blackwell, Robert; Glaser, Matthew A.; Betterton, M. D.; Shelley, Michael J.

2015-12-01

Microtubules and motor proteins self-organize into biologically important assemblies including the mitotic spindle and the centrosomal microtubule array. Outside of cells, microtubule-motor mixtures can form novel active liquid-crystalline materials driven out of equilibrium by adenosine triphosphate-consuming motor proteins. Microscopic motor activity causes polarity-dependent interactions between motor proteins and microtubules, but how these interactions yield larger-scale dynamical behavior such as complex flows and defect dynamics is not well understood. We develop a multiscale theory for microtubule-motor systems in which Brownian dynamics simulations of polar microtubules driven by motors are used to study microscopic organization and stresses created by motor-mediated microtubule interactions. We identify polarity-sorting and crosslink tether relaxation as two polar-specific sources of active destabilizing stress. We then develop a continuum Doi-Onsager model that captures polarity sorting and the hydrodynamic flows generated by these polar-specific active stresses. In simulations of active nematic flows on immersed surfaces, the active stresses drive turbulent flow dynamics and continuous generation and annihilation of disclination defects. The dynamics follow from two instabilities, and accounting for the immersed nature of the experiment yields unambiguous characteristic length and time scales. When turning off the hydrodynamics in the Doi-Onsager model, we capture formation of polar lanes as observed in the Brownian dynamics simulation.

Linear estimation discriminates midline sources and motor cortex contribution to the readiness potential

NARCIS (Netherlands)

Knosche, Thomas; Knosche, T.R.; Praamstra, Peter; Peters, M.J.; Stegeman, Dick; Stegeman, D.

1996-01-01

Spatiotemporal dipole modelling of the generators of the readiness potential (RP) prior to voluntary movements has yielded diverging results concerning the contributions of supplementary motor area (SMA) and primary motor cortex. We applied an alternative approach (i.e. linear estimation theory) to

The monomeric, tetrameric, and fibrillar organization of Fib: the dynamic building block of the bacterial linear motor of Spiroplasma melliferum BC3.

Science.gov (United States)

Cohen-Krausz, Sara; Cabahug, Pamela C; Trachtenberg, Shlomo

2011-07-08

Spiroplasmas belong to the class Mollicutes, representing the minimal, free-living, and self-replicating forms of life. Spiroplasmas are helical wall-less bacteria and the only ones known to swim by means of a linear motor (rather than the near-universal rotary bacterial motor). The linear motor follows the shortest path along the cell's helical membranal tube. The motor is composed of a flat monolayered ribbon of seven parallel fibrils and is believed to function in controlling cell helicity and motility through dynamic, coordinated, differential length changes in the fibrils. The latter cause local perturbations of helical symmetry, which are essential for net directional displacement in environments with a low Reynolds number. The underlying fibrils' core building block is a circular tetramer of the 59-kDa protein Fib. The fibrils' differential length changes are believed to be driven by molecular switching of Fib, leading consequently to axial ratio and length changes in tetrameric rings. Using cryo electron microscopy, diffractometry, single-particle analysis of isolated ribbons, and sequence analyses of Fib, we determined the overall molecular organization of the Fib monomer, tetramer, fibril, and linear motor of Spiroplasma melliferum BC3 that underlies cell geometry and motility. Fib appears to be a bidomained molecule, of which the N-terminal half is apparently a globular phosphorylase. By a combination of reversible rotation and diagonal shift of Fib monomers, the tetramer adopts either a cross-like nonhanded conformation or a ring-like handed conformation. The sense of Fib rotation may determine the handedness of the linear motor and, eventually, of the cell. A further change in the axial ratio of the ring-like tetramers controls fibril lengths and the consequent helical geometry. Analysis of tetramer quadrants from adjacent fibrils clearly demonstrates local differential fibril lengths. Copyright © 2011 Elsevier Ltd. All rights reserved.

Probing intracellular motor protein activity using an inducible cargo trafficking assay.

Science.gov (United States)

Kapitein, Lukas C; Schlager, Max A; van der Zwan, Wouter A; Wulf, Phebe S; Keijzer, Nanda; Hoogenraad, Casper C

2010-10-06

Although purified cytoskeletal motor proteins have been studied extensively with the use of in vitro approaches, a generic approach to selectively probe actin and microtubule-based motor protein activity inside living cells is lacking. To examine specific motor activity inside living cells, we utilized the FKBP-rapalog-FRB heterodimerization system to develop an in vivo peroxisomal trafficking assay that allows inducible recruitment of exogenous and endogenous kinesin, dynein, and myosin motors to drive specific cargo transport. We demonstrate that cargo rapidly redistributes with distinct dynamics for each respective motor, and that combined (antagonistic) actions of more complex motor combinations can also be probed. Of importance, robust cargo redistribution is readily achieved by one type of motor protein and does not require the presence of opposite-polarity motors. Simultaneous live-cell imaging of microtubules and kinesin or dynein-propelled peroxisomes, combined with high-resolution particle tracking, revealed that peroxisomes frequently pause at microtubule intersections. Titration and washout experiments furthermore revealed that motor recruitment by rapalog-induced heterodimerization is dose-dependent but irreversible. Our assay directly demonstrates that robust cargo motility does not require the presence of opposite-polarity motors, and can therefore be used to characterize the motile properties of specific types of motor proteins. Copyright © 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Development of sealed nickel-cadmium battery for linear motor car (Maglev). Linear motor car yo Ni-Cd denchi no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Kono, K; Yoshimura, H; Yufu, H [Yuasa Corp., Osaka (Japan)

1993-10-29

Development was made of a linear motor car use battery which is strong in repetition of quick charging/discharging and characterized as follows: Its volumetric energy density is 42Wh/kg which is 1.3 times as high as the conventional one. It excels in high efficiency charging/discharging characteristics. High tension steel sheet is used for it, which is incombustible. To lighten the weight, paste type electrodes and high yield point materials were used for the positive and negative electrodes, and jar materials, respectively. To heighten the charging/discharging characteristics, used were electrodes heightened in current collecting effect. To lengthening the life, unwoven nylon cloth was used as a separator. Also to heighten the thermal discharge characteristics, the electrodes were made metallic with a fitting of cooling fins. The battery characteristics as tested gave the following result: At a capacity ratio of 100%, the discharging factor cleared its target value of development also with a high discharging voltage. The charging/discharging characteristics hardly fall in the high temperature region. The charging characteristics include quick charging made possible. As a result of cyclic simulation presuming the linear motor car, the fall in capacity per cycle was as good as 1.5%. 11 figs., 2 tabs.

Design of decoupled dual servo stage with voice coil motor and linear motor for XY long stroke ultra-precision scanning system

Science.gov (United States)

Kim, Ki-Hyun; Choi, Young-Man; Gweon, Dae-Gab; Hong, Dong-Pyo; Kim, Koung-Suk; Lee, Suk-Won; Lee, Moon-Gu

2005-12-01

A decoupled dual servo (DDS) stage for ultra-precision scanning system is introduced in this paper. The proposed DDS consists of a 3 axis fine stage for handling and carrying workpieces and a XY coarse stage. Especially, the DDS uses three voice coil motors (VCM) as a planar actuation system of the fine stage to reduce the disturbances due to any mechanical connections with its coarse stage. VCMs are governed by Lorentz law. According to the law and its structure, there are no mechanical connections between coils and magnetic circuits. Moreover, the VCM doesn't have force ripples due to imperfections of commutation components of linear motor systems - currents and flux densities. However, due to the VCM's mechanical constraints the working range of the fine is about 5mm2. To break that hurdle, the coarse stage with linear motors is used for the fine stage to move about 200mm2. Because of the above reasons, the proposed DDS can achieve higher precision scanning than other stages with only one servo. Using MATLAB's Sequential Quadratic Programming (SQP), the VCMs are optimally designed for the highest force under conditions and constraints such as thermal dissipations due to its coil, its size, and so on. For linear motors, Halbach magnet linear motor is proposed and optimally designed in this paper. In addition, for their smooth movements without any frictions, guide systems of the DDS are composed of air bearings. And then, precisely to get their positions, linear scales with 0.1um resolution are used for the coarse's XY motions and plane mirror laser interferometers with 20nm for the fine's XYθz. On scanning, the two stages have same trajectories and are controlled. The control algorithm is Parallel method. The embodied ultra-precision scanning system has about 100nm tracking error and in-positioning stability.

PERFORMANCE OPTIMIZATION OF LINEAR INDUCTION MOTOR BY EDDY CURRENT AND FLUX DENSITY DISTRIBUTION ANALYSIS

Directory of Open Access Journals (Sweden)

M. S. MANNA

2011-12-01

Full Text Available The development of electromagnetic devices as machines, transformers, heating devices confronts the engineers with several problems. For the design of an optimized geometry and the prediction of the operational behaviour an accurate knowledge of the dependencies of the field quantities inside the magnetic circuits is necessary. This paper provides the eddy current and core flux density distribution analysis in linear induction motor. Magnetic flux in the air gap of the Linear Induction Motor (LIM is reduced to various losses such as end effects, fringes, effect, skin effects etc. The finite element based software package COMSOL Multiphysics Inc. USA is used to get the reliable and accurate computational results for optimization the performance of Linear Induction Motor (LIM. The geometrical characteristics of LIM are varied to find the optimal point of thrust and minimum flux leakage during static and dynamic conditions.

Linear magnetic spring and spring/motor combination

Science.gov (United States)

Patt, Paul J. (Inventor); Stolfi, Fred R. (Inventor)

1991-01-01

A magnetic spring, or a spring and motor combination, providing a linear spring force characteristic in each direction from a neutral position, in which the spring action may occur for any desired coordinate of a typical orthogonal coordinate system. A set of magnets are disposed, preferably symmetrically about a coordinate axis, poled orthogonally to the desired force direction. A second set of magnets, respectively poled opposite the first set, are arranged on the sprung article. The magnets of one of the sets are spaced a greater distance apart than those of the other, such that an end magnet from each set forms a pair having preferably planar faces parallel to the direction of spring force, the faces being offset so that in a neutral position the outer edge of the closer spaced magnet set is aligned with the inner edge of the greater spaced magnet set. For use as a motor, a coil can be arranged with conductors orthogonal to both the magnet pole directions and the direction of desired spring force, located across from the magnets of one set and fixed with respect to the magnets of the other set. In a cylindrical coordinate system having axial spring force, the magnets are radially poled and motor coils are concentric with the cylinder axis.

Analysis of the linear induction motor in transient operation

Energy Technology Data Exchange (ETDEWEB)

Gentile, G; Rotondale, N; Scarano, M

1987-05-01

The paper deals with the analysis of a bilateral linear induction motor in transient operation. We have considered an impressed voltage one-dimensional model which takes into account end effects. The real winding distribution of the armature has been represented as a lumped parameters system. By using the space vectors methodology, the partial differential equation of the sheet is solved bythe variable separation method. Therefore it's possible to arrange a system of ordinary differential equations where the unknown quantities are the space vectors of the air-gap flux density and sheet currents. Finally, we have analyzed the characteristic quantities for a no-load starting of small power motors.

Position sensor for linear synchronous motors employing halbach arrays

Science.gov (United States)

Post, Richard Freeman

2014-12-23

A position sensor suitable for use in linear synchronous motor (LSM) drive systems employing Halbach arrays to create their magnetic fields is described. The system has several advantages over previously employed ones, especially in its simplicity and its freedom from being affected by weather conditions, accumulated dirt, or electrical interference from the LSM system itself.

Linear hypergeneralization of learned dynamics across movement speeds reveals anisotropic, gain-encoding primitives for motor adaptation.

Science.gov (United States)

Joiner, Wilsaan M; Ajayi, Obafunso; Sing, Gary C; Smith, Maurice A

2011-01-01

The ability to generalize learned motor actions to new contexts is a key feature of the motor system. For example, the ability to ride a bicycle or swing a racket is often first developed at lower speeds and later applied to faster velocities. A number of previous studies have examined the generalization of motor adaptation across movement directions and found that the learned adaptation decays in a pattern consistent with the existence of motor primitives that display narrow Gaussian tuning. However, few studies have examined the generalization of motor adaptation across movement speeds. Following adaptation to linear velocity-dependent dynamics during point-to-point reaching arm movements at one speed, we tested the ability of subjects to transfer this adaptation to short-duration higher-speed movements aimed at the same target. We found near-perfect linear extrapolation of the trained adaptation with respect to both the magnitude and the time course of the velocity profiles associated with the high-speed movements: a 69% increase in movement speed corresponded to a 74% extrapolation of the trained adaptation. The close match between the increase in movement speed and the corresponding increase in adaptation beyond what was trained indicates linear hypergeneralization. Computational modeling shows that this pattern of linear hypergeneralization across movement speeds is not compatible with previous models of adaptation in which motor primitives display isotropic Gaussian tuning of motor output around their preferred velocities. Instead, we show that this generalization pattern indicates that the primitives involved in the adaptation to viscous dynamics display anisotropic tuning in velocity space and encode the gain between motor output and motion state rather than motor output itself.

A speed estimation unit for induction motors based on adaptive linear combiner

International Nuclear Information System (INIS)

Marei, Mostafa I.; Shaaban, Mostafa F.; El-Sattar, Ahmed A.

2009-01-01

This paper presents a new induction motor speed estimation technique, which can estimate the rotor resistance as well, from the measured voltage and current signals. Moreover, the paper utilizes a novel adaptive linear combiner (ADALINE) structure for speed and rotor resistance estimations. This structure can deal with the multi-output systems and it is called MO-ADALINE. The model of the induction motor is arranged in a linear form, in the stationary reference frame, to cope with the proposed speed estimator. There are many advantages of the proposed unit such as wide speed range capability, immunity against harmonics of measured waveforms, and precise estimation of the speed and the rotor resistance at different dynamic changes. Different types of induction motor drive systems are used to evaluate the dynamic performance and to examine the accuracy of the proposed unit for speed and rotor resistance estimation.

Investigation and Calculation of Magnetic Field in Tubular Linear Reluctance Motor Using FEM

Directory of Open Access Journals (Sweden)

MOSALLANEJAD, A.

2010-11-01

Full Text Available In this paper the magnetic flux density of tubular linear reluctance motor (TLRM in open type magnetic circuit is studied. Also, all magnetic flux density calculation methods in winding of tubular linear reluctance motor are described. The effect of structure parameters on magnetic flux density is also discussed. Electromagnetic finite-element analysis is used for simulation of magnetic field, and simulation results of the magnetic field analysis with DC voltage excitation are compared with results obtained from calculation methods. The comparison yields a good agreement.

Bidirectional electrostatic linear shuffle motor with two degrees of freedom

NARCIS (Netherlands)

Sarajlic, Edin; Berenschot, Johan W.; Fujita, H.; Krijnen, Gijsbertus J.M.; Elwenspoek, Michael Curt

2005-01-01

We report on an electrostatic linear inchworm micromotor with two translational degrees-of-freedom. The motor employs built-in mechanical leverage to convert normal deflection of a flexible cross-plate into a small in-plane step and four electrostatic clamps to enable bidirectional inchworm motion

Force measurements on a shielded coreless linear permanent magnet motor

NARCIS (Netherlands)

Pluk, K.J.W.; Jansen, J.W.; Lomonova, E.A.

2014-01-01

This paper compares force measurements on a shielded coreless linear permanent magnet motor with 2-D models. A 2-D semianalytical modeling method is applied, which is based on Fourier modeling and includes force calculations. The semianalytical modeling correctly predicts the behavior found in the

Linear switched reluctance motor control with PIC18F452 microcontroller

OpenAIRE

DURSUN, Mahir; KOÇ, Fatmagül

2014-01-01

This paper presents the simulation, control, and experimental results of the velocity of a double-sided, 6/4-poled, 3-phased, 8 A, 24 V, 250 W, and 250 N pull force linear switched reluctance motor (LSRM). In the simulation and experimental study, the reference velocity is constant depending on the position and time. The velocity versus the position of the translator was controlled with fuzzy logic control (FLC) and proportional-integral (PI) control techniques. The motor was control...

CONFIRMATION OF THE MATHEMATICAL MODEL ADEQUACY OF A LINEAR SYNCHRONOUS MOTOR

Directory of Open Access Journals (Sweden)

V. F. Novikov

2015-06-01

Full Text Available Purpose.To reduce labor costs and the amount of computer time in the design of linear synchronous motors with excitation from a source of a constant magnetic field of high-speed ground transportation it is necessary to use engineering methods. The purpose of this study is to confirm the adequacy of the previously proposed mathematical model of this engine and assumptions. It is also intended to confirm the possibility of applying the method of calculation of traction that occurs in the engine in the interaction of the permanent magnetic field of the excitation system of a vehicle with a coil track structure.Methodology. As for empirical theories the positive result of the experiment is not absolute proof of the truth, for an unambiguous conclusion about the adequacy of the developed model and the effectiveness of the developed methods need to be tested for falsification. In accordance with this criterion, it is necessary to conduct an experiment, the results of which will coincide with the calculation but you also need to avoid errors caused by random coincidences. For this purpose the experiments with varying parameters are conducted. Findings. In a critical experiment configuration changes of the excitation system were held so that the shape dependence of traction from displacement is differed significantly. The comparison of the results of the calculated and experimental values of traction for different configurations showed that the differences are minor and easily explained by measurement error and uneven gaps between the poles and excitation coils of the track structure. Originality. The adequacy of the mathematical model of a linear synchronous motor without a ferromagnetic magnetic circuit and the assumptions and applicability of the calculation method of traction forces involved in it, at the interaction of a permanent magnetic field of the excitation system of a vehicle with a coil track structure were proved. This proof is built on

Influence analysis of structural parameters on electromagnetic properties of HTS linear induction motor

International Nuclear Information System (INIS)

Zhao, J.; Zheng, T.Q.; Zhang, W.; Fang, J.; Liu, Y.M.

2011-01-01

A new type high temperature superconductor linear induction motor is designed and analyzed as a prototype to ensure applicability aimed at industrial motors. Made of Bi-2223/Ag, primary windings are distributed with the double-layer concentrated structure. The motor is analyzed by 2D electromagnetic Finite Element Method to get magnetic field distribution, thrust force, vertical force and so on. The critical current of motor and the electromagnetic force are mostly decided by the leakage flux density of primary slot and by the main magnetic flux and eddy current respectively. The structural parameters of motor have a great influence on the distribution of magnetic field. Under constant currents, the properties of motor are analyzed with different slot widths, slot heights and winding turns. The properties of motor, such as the maximum slot leakage flux density, motor thrust and motor vertical force, are analyzed with different structural parameters.

Force analysis of linear induction motor for magnetic levitation system

NARCIS (Netherlands)

Kuijpers, A.A.; Nemlioglu, C.; Sahin, F.; Verdel, A.J.D.; Compter, J.C.; Lomonova, E.

2010-01-01

This paper presents the analyses of thrust and normal forces of linear induction motor (LIM) segments which are implemented in a rotating ring system. To obtain magnetic levitation in a cost effective and sustainable way, decoupled control of thrust and normal forces is required. This study includes

CONTRIBUTIONS TO THE FINITE ELEMENT MODELING OF LINEAR ULTRASONIC MOTORS

Directory of Open Access Journals (Sweden)

Oana CHIVU

2013-05-01

Full Text Available The present paper is concerned with the main modeling elements as produced by means of thefinite element method of linear ultrasonic motors. Hence, first the model is designed and then a modaland harmonic analysis are carried out in view of outlining the main outcomes

Power-optimal force decoupling in a hybrid linear reluctance motor

NARCIS (Netherlands)

Overboom, T.T.; Smeets, J.P.C.; Jansen, J.W.; Lomonova, E.A.; Mavrudieva, D.

2015-01-01

This paper concerns the power-optimal decoupling of the propulsion and normal force created by a hybrid linear reluctance motor. The intrinsic limitations to the decoupling is addressed by the visualizing each force component with a quadric surface in the Euclidean space which is spanned by the

Impact of fluorescent protein fusions on the bacterial flagellar motor.

Science.gov (United States)

Heo, M; Nord, A L; Chamousset, D; van Rijn, E; Beaumont, H J E; Pedaci, F

2017-10-03

Fluorescent fusion proteins open a direct and unique window onto protein function. However, they also introduce the risk of perturbation of the function of the native protein. Successful applications of fluorescent fusions therefore rely on a careful assessment and minimization of the side effects, but such insight is still lacking for many applications. This is particularly relevant in the study of the internal dynamics of motor proteins, where both the chemical and mechanical reaction coordinates can be affected. Fluorescent proteins fused to the stator of the Bacterial Flagellar Motor (BFM) have previously been used to unveil the motor subunit dynamics. Here we report the effects on single motors of three fluorescent proteins fused to the stators, all of which altered BFM behavior. The torque generated by individual stators was reduced while their stoichiometry remained unaffected. MotB fusions decreased the switching frequency and induced a novel bias-dependent asymmetry in the speed in the two directions. These effects could be mitigated by inserting a linker at the fusion point. These findings provide a quantitative account of the effects of fluorescent fusions to the stator on BFM dynamics and their alleviation- new insights that advance the use of fluorescent fusions to probe the dynamics of protein complexes.

Apparatus and method to pulverize rock using a superconducting electromagnetic linear motor

Science.gov (United States)

Ignatiev, Alex (Inventor)

2009-01-01

A rock pulverizer device based on a superconducting linear motor. The superconducting electromagnetic rock pulverizer accelerates a projectile via a superconducting linear motor and directs the projectile at high speed toward a rock structure that is to be pulverized by collision of the speeding projectile with the rock structure. The rock pulverizer is comprised of a trapped field superconducting secondary magnet mounted on a movable car following a track, a wire wound series of primary magnets mounted on the track, and the complete magnet/track system mounted on a vehicle used for movement of the pulverizer through a mine as well as for momentum transfer during launch of the rock breaking projectile.

A novel linear switched reluctance motor for railway transportation systems

International Nuclear Information System (INIS)

Daldaban, Ferhat; Ustkoyuncu, Nurettin

2010-01-01

This paper presents the design and realization of a new linear switched reluctance motor (LSRM) structure, especially suitable for high-speed railway systems. The new model has a double active stator configuration and provides high force for many applications with low cost. The characteristics of the LSRM are obtained by using finite element analysis (FEA) and analytical calculations. The results of the FEA and analytical calculations are presented, and compared with experimental results. In addition, a classical double-sided LSRM (DSLSRM) is modeled with the same specifications of the new motor structure and the results are compared.

Influence of a high vacuum on the precise positioning using an ultrasonic linear motor.

Science.gov (United States)

Kim, Wan-Soo; Lee, Dong-Jin; Lee, Sun-Kyu

2011-01-01

This paper presents an investigation of the ultrasonic linear motor stage for use in a high vacuum environment. The slider table is driven by the hybrid bolt-clamped Langevin-type ultrasonic linear motor, which is excited with its different modes of natural frequencies in both lateral and longitudinal directions. In general, the friction behavior in a vacuum environment becomes different from that in an environment of atmospheric pressure and this difference significantly affects the performance of the ultrasonic linear motor. In this paper, to consistently provide stable and high power of output in a high vacuum, frequency matching was conducted. Moreover, to achieve the fine control performance in the vacuum environment, a modified nominal characteristic trajectory following control method was adopted. Finally, the stage was operated under high vacuum condition, and the operating performances were investigated compared with that of a conventional PI compensator. As a result, robustness of positioning was accomplished in a high vacuum condition with nanometer-level accuracy.

Influence of a high vacuum on the precise positioning using an ultrasonic linear motor

International Nuclear Information System (INIS)

Kim, Wan-Soo; Lee, Dong-Jin; Lee, Sun-Kyu

2011-01-01

This paper presents an investigation of the ultrasonic linear motor stage for use in a high vacuum environment. The slider table is driven by the hybrid bolt-clamped Langevin-type ultrasonic linear motor, which is excited with its different modes of natural frequencies in both lateral and longitudinal directions. In general, the friction behavior in a vacuum environment becomes different from that in an environment of atmospheric pressure and this difference significantly affects the performance of the ultrasonic linear motor. In this paper, to consistently provide stable and high power of output in a high vacuum, frequency matching was conducted. Moreover, to achieve the fine control performance in the vacuum environment, a modified nominal characteristic trajectory following control method was adopted. Finally, the stage was operated under high vacuum condition, and the operating performances were investigated compared with that of a conventional PI compensator. As a result, robustness of positioning was accomplished in a high vacuum condition with nanometer-level accuracy.

Dynamic diagnostics of moving ferromagnetic material with the linear induction motor

OpenAIRE

Szewczyk Krzysztof; Walasek Tomasz

2017-01-01

The paper presents the application of a three-phase induction motor as a sensor measuring the force of the electromagnetic field connection between the engine and produced sheet steel. The force interaction between the engine and the manufactured sheet metal treated as a treadmill for a linear motor may be an indicator of damage to the material. Detection of places where the sheet does not meet the quality requirements may be very useful in the production process. FEM calculations were perfor...

Drive of a rail locomotive using linear motors. Antrieb eines schienengebundenen Triebfahrzeuges mit Hilfe von Linearmotoren

Energy Technology Data Exchange (ETDEWEB)

Kagischke, W; Steffen, U

1977-12-08

The purpose of the invention is to avoid the disadvantages of asynchronous linear motors, for example for need for reactive current for excitation, where driving on a normal section and driving on a branch line should be possible without losing the saving in weight on the inductor. According to the invention, the common inductor on a synchronous linear motor consists of 2 parallel packets of laminations surrounded by DC excitation windings and the secondary systems consists of unwound and spaced magnetic sections covering the two packets of laminations on the normal section. In the direction of thrust, their length extends nearly over the pole pitch of the multi-phase AC winding. According to the invetnion, this drive therefore consists of a synchronous linear motor combined into a double motor, with an external, rail shaped fixed secondary system, which has a multi-phase AC winding opposite it.

Motoring through: the role of kinesin superfamily proteins in female meiosis.

Science.gov (United States)

Camlin, Nicole J; McLaughlin, Eileen A; Holt, Janet E

2017-07-01

The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. This article contains a review of the literature with respect to the role of kinesin motor proteins in female meiosis in model species. Throughout, we discuss the function of each class of kinesin proteins during oocyte meiosis, and where such data are not available their role in mitosis is considered. Finally, the review highlights the potential clinical importance of this family of proteins for human oocyte quality. To examine the role of kinesin motor proteins in oocyte meiosis. A search was performed on the Pubmed database for journal articles published between January 1970 and February 2017. Search terms included 'oocyte kinesin' and 'meiosis kinesin' in addition to individual kinesin names with the terms oocyte or meiosis. Within human cells 45 kinesin motor proteins have been discovered, with the role of only 13 of these proteins, or their orthologues, investigated in female meiosis. Furthermore, of these kinesins only half have been examined in mammalian oocytes, despite alterations occurring in gene transcripts or protein expression with maternal ageing, cryopreservation or behavioral conditions, such as binge drinking, for many of them. Kinesin motor proteins have distinct and important roles throughout oocyte meiosis in many non-mammalian model species. However, the functions these proteins have in mammalian meiosis, particularly in humans, are less clear owing to lack of research. This review brings to light the need for more experimental investigation of kinesin motor proteins, particularly those associated with maternal ageing, cryopreservation or exposure to

Analysis and testing of a double armature brushless dc linear motor with NdFeB permanent magnets

International Nuclear Information System (INIS)

Filho, A.F.F.

1998-01-01

The use of high-energy product NdFeB permanent magnets benefits the design and features of a double armature brushless dc linear motor. As the linear motor is also slotless, its 5 mm airgap requires a source of high flux to overcome the reluctance and produce an adequate amount of force. The linear motor employs a topology that makes use of five permanent magnets to provide excitation flux. The permanent magnets are arranged in such a way that maximises the force the linear motor can deliver. The actuator produces a force up to 86.2 N at an armature current of 4.5 A. However, the topology makes the actuator prone to saturation. It affects the operation point of the permanent magnets, reduces the airgap flux density and the force, and increases flux leakage. To avoid saturation, a flux compensation scheme was conceived. The results are presented and assessed by means of finite element simulation and by experimental results that presented a good agreement. (orig.)

Design and experiments of a linear piezoelectric motor driven by a single mode.

Science.gov (United States)

Liu, Zhen; Yao, Zhiyuan; Li, Xiang; Fu, Qianwei

2016-11-01

In this contribution, we propose a novel linear piezoelectric motor with a compact stator that is driven by a single mode. The linear piezoelectric motor can realize bidirectional motion by changing the vibration modes of the stator. Finite element analysis is performed to determine the required vibration mode of the stator and obtain the optimal stator structure and dimensions. Furthermore, the trajectories of the driving foot are analyzed with and without consideration of the mechanical contact with the slider. It is shown that the trajectory of the driving foot is an oblique line when disregarding the contact, and the trajectory becomes an oblique ellipse while taking into account the contact. Finally, a prototype of the motor is fabricated based on the results of finite element analysis. The optimization results show that the motor reaches its maximum thrust force of 4.0 kg, maximum thrust-weight ratio of 33.3, maximum unloaded velocity of 385 mm/s under the excitation of Mode-B, and maximum unloaded velocity of 315 mm/s under the excitation of Mode-L.

Magnetically Suspended Linear Pulse Motor for Semiconductor Wafer Transfer in Vacuum Chamber

Science.gov (United States)

Moriyama, Shin-Ichi; Hiraki, Naoji; Watanabe, Katsuhide; Kanemitsu, Yoichi

1996-01-01

This paper describes a magnetically suspended linear pulse motor for a semiconductor wafer transfer robot in a vacuum chamber. The motor can drive a wafer transfer arm horizontally without mechanical contact. In the construction of the magnetic suspension system, four pairs of linear magnetic bearings for the lift control are used for the guidance control as well. This approach allows us to make the whole motor compact in size and light in weight. The tested motor consists of a double-sided stator and a transfer arm with a width of 50 mm and a total length of 700 mm. The arm, like a ladder in shape, is designed as the floating element with a tooth width of 4 mm (a tooth pitch of 8 mm). The mover mass is limited to about 1.6 kg by adopting such an arm structure, and the ratio of thrust to mover mass reaches to 3.2 N/kg under a broad air gap (1 mm) between the stator teeth and the mover teeth. The performance testing was carried out with a transfer distance less than 450 mm and a transfer speed less than 560 mm/s. The attitude of the arm was well controlled by the linear magnetic bearings with a combined use, and consequently the repeatability on the positioning of the arm reached to about 2 micron. In addition, the positioning accuracy was improved up to about 30 micron through a compensation of the 128-step wave current which was used for the micro-step drive with a step increment of 62.5 micron.

Driving performance of a two-dimensional homopolar linear DC motor

Energy Technology Data Exchange (ETDEWEB)

Wang, Y.; Yamaguchi, M.; Kano, Y. [Tokyo University of Agriculture and Technology, Tokyo (Japan)

1998-05-01

This paper presents a novel two-dimensional homopolar linear de motor (LDM) which can realize two-dimensional (2-D) motion. For position control purposes, two kinds of position detecting methods are proposed. The position in one position is detected by means of a capacitive sensor which makes the output of the sensor partially immune to the variation of the gap between electrodes. The position in the other direction is achieved by exploiting the position dependent property of the driving coil inductance, instead of using an independent sensor. The position control is implemented on the motor and 2-D tracking performance is analyzed. Experiments show that the motor demonstrates satisfactory driving performance, 2-D tracking error being within 5.5% when the angular frequency of reference signal is 3.14 rad./s. 7 refs., 17 figs., 2 tabs.

Mechanical design of translocating motor proteins.

Science.gov (United States)

Hwang, Wonmuk; Lang, Matthew J

2009-01-01

Translocating motors generate force and move along a biofilament track to achieve diverse functions including gene transcription, translation, intracellular cargo transport, protein degradation, and muscle contraction. Advances in single molecule manipulation experiments, structural biology, and computational analysis are making it possible to consider common mechanical design principles of these diverse families of motors. Here, we propose a mechanical parts list that include track, energy conversion machinery, and moving parts. Energy is supplied not just by burning of a fuel molecule, but there are other sources or sinks of free energy, by binding and release of a fuel or products, or similarly between the motor and the track. Dynamic conformational changes of the motor domain can be regarded as controlling the flow of free energy to and from the surrounding heat reservoir. Multiple motor domains are organized in distinct ways to achieve motility under imposed physical constraints. Transcending amino acid sequence and structure, physically and functionally similar mechanical parts may have evolved as nature's design strategy for these molecular engines.

Conformational dynamics of ATP/Mg:ATP in motor proteins via data mining and molecular simulation

Science.gov (United States)

Bojovschi, A.; Liu, Ming S.; Sadus, Richard J.

2012-08-01

The conformational diversity of ATP/Mg:ATP in motor proteins was investigated using molecular dynamics and data mining. Adenosine triphosphate (ATP) conformations were found to be constrained mostly by inter cavity motifs in the motor proteins. It is demonstrated that ATP favors extended conformations in the tight pockets of motor proteins such as F1-ATPase and actin whereas compact structures are favored in motor proteins such as RNA polymerase and DNA helicase. The incorporation of Mg2+ leads to increased flexibility of ATP molecules. The differences in the conformational dynamics of ATP/Mg:ATP in various motor proteins was quantified by the radius of gyration. The relationship between the simulation results and those obtained by data mining of motor proteins available in the protein data bank is analyzed. The data mining analysis of motor proteins supports the conformational diversity of the phosphate group of ATP obtained computationally.

High Precision Piezoelectric Linear Motors for Operations at Cryogenic Temperatures and Vacuum

Science.gov (United States)

Wong, D.; Carman, G.; Stam, M.; Bar-Cohen, Y.; Sen, A.; Henry, P.; Bearman, G.; Moacanin, J.

1995-01-01

The Jet Propulsion Laboratory evaluated the use of an electromechanical device for optically positioning a mirror system during the pre-project phase of the Pluto-Fast-Flyby (PFF) mission. The device under consideration was a piezoelectric driven linear motor functionally dependent upon a time varying electric field which induces displacements ranging from submicrons to millimeters with positioning accuracy within nanometers. Using a control package, the mirror system provides image motion compensation and mosaicking capabilities. While this device offers unique advantages, there were concerns pertaining to its operational capabilities for the PFF mission. The issues include irradiation effects and thermal concerns. A literature study indicated that irradiation effects will not significantly impact the linear motor's operational characteristics. On the other hand, thermal concerns necessitated an in depth study.

Dynamic modeling and characteristics analysis of a modal-independent linear ultrasonic motor.

Science.gov (United States)

Li, Xiang; Yao, Zhiyuan; Zhou, Shengli; Lv, Qibao; Liu, Zhen

2016-12-01

In this paper, an integrated model is developed to analyze the fundamental characteristics of a modal-independent linear ultrasonic motor with double piezoelectric vibrators. The energy method is used to model the dynamics of the two piezoelectric vibrators. The interface forces are coupled into the dynamic equations of the two vibrators and the moving platform, forming a whole machine model of the motor. The behavior of the force transmission of the motor is analyzed via the resulting model to understand the drive mechanism. In particular, the relative contact length is proposed to describe the intermittent contact characteristic between the stator and the mover, and its role in evaluating motor performance is discussed. The relations between the output speed and various inputs to the motor and the start-stop transients of the motor are analyzed by numerical simulations, which are validated by experiments. Furthermore, the dead-zone behavior is predicted and clarified analytically using the proposed model, which is also observed in experiments. These results are useful for designing servo control scheme for the motor. Copyright © 2016 Elsevier B.V. All rights reserved.

Force Profiles of a Linear Switched Reluctance Motor Having Special Pole Face Shapes

Directory of Open Access Journals (Sweden)

CHADRESEKAR, V.

2010-11-01

Full Text Available In this paper, the results of a finite element analysis are carried out on an new stator geometry of a three phase longitudinal flux Linear Switched Reluctance Motor (LSRM. In the new geometry, pole shoes are affixed to the stator poles. Static and dynamic characteristics for the proposed structure have been highlighted. Motor performance for variable load conditions is discussed. Frequency spectrum analyses of force profile using the fast Fourier transform (FFT are described to predict the vibration frequencies. The 2-Dimensional (2-D finite element analysis (FEA and the experimental results of this paper prove that LSRMs are one of the strong candidates for linear propulsion drives.

A superconducting linear motor drive for a positive displacement bellows pump for use in the g-2 cryogenics system

International Nuclear Information System (INIS)

Green, M.A.

1994-10-01

Forced two-phase cooling of indirectly cooled magnets requires circulation of liquid helium through the magnet cooling channel. A bellows helium pump is one possible way of providing helium flow to a magnet cooling system. Since the bellows type of helium pump is immersed in liquid helium, a superconducting linear motor drive appears to be an attractive option. This report describes a linear motor drive that employs oriented permanent magnet materials such as samarium-cobalt as the stator magnet system and a superconducting loud speaker voice coil type of drive as the armature of the linear motor. This report examines drive motor requirements for a helium pump

Resettable binary latch mechanism for use with paraffin linear motors

Science.gov (United States)

Maus, Daryl; Tibbitts, Scott

1991-01-01

A new resettable Binary Latch Mechanism was developed utilizing a paraffin actuator as the motor. This linear actuator alternately latches between extended and retracted positions, maintaining either position with zero power consumption. The design evolution and kinematics of the latch mechanism are presented, as well as the development problems and lessons that were learned.

Thermal analysis of linear pulse motor for SMART control element drive mechanism

International Nuclear Information System (INIS)

Hur, H.; Kim, J. H.; Kim, J. I.; Jang, K. C.; Kang, D. H.

1999-01-01

It is important that the temperature of the motor windings be maintained within the allowable limit of the insulation, since the linear pulse motor of CEDM is always supplied with current during the reactor operation. In this study three motor windings were fabricated with three different diameters of coil wires, and the temperatures inside the windings were measured with different current values. As the insulation of the windings is composed of teflon, glass fiber, and air, it is not an easy task to determine experimentally the thermal properties of the complex insulation. In this study, the thermal properties of the insulation were obtained by comparing the results of finite element thermal analyses and those of experiment. The thermal properties obtained here will be used as input for the optimization analysis of the motor

Efficiency Improvement of a High Dynamic BLDC Linear Motor by Multiphase Control

OpenAIRE

Lemmens, Joris; Vanvlasselaer, Kris; Mulier, Kristof; Goossens, Stijn; Symens, Wim; Driesen, Johan

2013-01-01

This paper proposes a multiphase control strategy for a high dynamic brushless DC linear motor as an alternative for conventional three-phase field-oriented control. Analysis of the magnetic field waveforms shows that three-phase control is not optimal for the 6-slot 7-pole motor topology. Therefore, a multiphase control strategy is elaborated which injects currents proportional to the electromotive force into each of the nine stator coil groups. This results in a maximal alignment force ...

Thrust Reduction of Magnetic Levitation Vehicle Driven by Long Stator Linear Synchronous Motor

Directory of Open Access Journals (Sweden)

Wan-Tsun Tseng

2013-01-01

Full Text Available The propulsion technology of long stator linear synchronous motors is used to drive high-speed maglev trains. The linear synchronous motor stator is divided into sections placed on guideway. The electric power supplies to stator sections in which the train just passes in change-step mode for long-distance operation. However, a thrust drop will be caused by change-step machinery for driving magnetic vehicle. According to the train speed and vehicle data, the change-step mode has three types of operation, namely premature commutation, simultaneous commutation, and late commutation. Each type of operation has a different thrust drop which can be affected by several parameters such as jerk, running speed, motor section length, and vehicle data. This paper focuses on determining the thrust drop of the change-step mode. The study results of this paper can be used to improve the operation system of high-speed maglev trains.

Novel permanent magnet linear motor with isolated movers: analytical, numerical and experimental study.

Science.gov (United States)

Yan, Liang; Peng, Juanjuan; Jiao, Zongxia; Chen, Chin-Yin; Chen, I-Ming

2014-10-01

This paper proposes a novel permanent magnet linear motor possessing two movers and one stator. The two movers are isolated and can interact with the stator poles to generate independent forces and motions. Compared with conventional multiple motor driving system, it helps to increase the system compactness, and thus improve the power density and working efficiency. The magnetic field distribution is obtained by using equivalent magnetic circuit method. Following that, the formulation of force output considering armature reaction is carried out. Then inductances are analyzed with finite element method to investigate the relationships of the two movers. It is found that the mutual-inductances are nearly equal to zero, and thus the interaction between the two movers is negligible. A research prototype of the linear motor and a measurement apparatus on thrust force have been developed. Both numerical computation and experiment measurement are conducted to validate the analytical model of thrust force. Comparison shows that the analytical model matches the numerical and experimental results well.

Numerical studies on the force characteristic of superconducting linear synchronous motor with HTS bulk magnet

Science.gov (United States)

Tang, Junjie; Li, Jing; Li, Xiang; Han, Le

2018-03-01

High temperature superconductor (HTS) bulks have significant potential use in linear motor application act as quasi-permanent magnet to replace traditional magnets. Force characteristic between HTS bulk magnet and traveling magnetic field was investigated with numerical simulation and experimental measurement in this paper. Influences of bulk height and number on the force characteristic were studied by the finite element model considering the nonlinear E-J relationship. Study was also made on addition of a back iron plate to the bulk magnet. Besides, force characteristic of bulk was compared with the permanent magnet results. The small initial decrease of the thrust could be explained by inside superconducting current redistribution. It was found that efficiency of linear motor did not increase by adding more bulk magnets. The bulk magnet will be remagnetized instead of erasing trapped field with the increase of the traveling magnetic field strength. The conclusions are helpful in prediction and design the linear motor with HTS bulk magnet.

Computer-aided design studies of the homopolar linear synchronous motor

Science.gov (United States)

Dawson, G. E.; Eastham, A. R.; Ong, R.

1984-09-01

The linear induction motor (LIM), as an urban transit drive, can provide good grade-climbing capabilities and propulsion/braking performance that is independent of steel wheel-rail adhesion. In view of its 10-12 mm airgap, the LIM is characterized by a low power factor-efficiency product of order 0.4. A synchronous machine offers high efficiency and controllable power factor. An assessment of the linear homopolar configuration of this machine is presented as an alternative to the LIM. Computer-aided design studies using the finite element technique have been conducted to identify a suitable machine design for urban transit propulsion.

A square-plate piezoelectric linear motor operating in two orthogonal and isomorphic face-diagonal-bending modes.

Science.gov (United States)

Ci, Penghong; Chen, Zhijiang; Liu, Guoxi; Dong, Shuxiang

2014-01-01

We report a piezoelectric linear motor made of a single Pb(Zr,Ti)O3 square-plate, which operates in two orthogonal and isomorphic face-diagonal-bending modes to produce precision linear motion. A 15 × 15 × 2 mm prototype was fabricated, and the motor generated a driving force of up to 1.8 N and a speed of 170 mm/s under an applied voltage of 100 Vpp at the resonance frequency of 136.5 kHz. The motor shows such advantages as large driving force under relatively low driving voltage, simple structure, and stable motion because of its isomorphic face-diagonal-bending mode.

A study on the integration of contactless energy transfer in the end teeth of a PM synchronous linear motor

NARCIS (Netherlands)

Krop, D.C.J.; Lomonova, E.A.; Jansen, J.W.; Paulides, J.J.H.

2009-01-01

Linear motors find their utilization in an increasing number of industrial applications. Permanent magnet linear synchronous motors (PMLSMs) are favorable in many applications due to their servo characteristics, robustness, and high force density. The major disadvantage of moving coil type PMLSMs is

Mathematical Model and Computational Analysis of Selected Transient States of Cylindrical Linear Induction Motor Fed via Frequency Converter

Directory of Open Access Journals (Sweden)

Andrzej Rusek

2008-01-01

Full Text Available The mathematical model of cylindrical linear induction motor (C-LIM fed via frequency converter is presented in the paper. The model was developed in order to analyze numerically the transient states. Problems concerning dynamics of ac-machines especially linear induction motor are presented in [1 – 7]. Development of C-LIM mathematical model is based on circuit method and analogy to rotary induction motor. The analogy between both: (a stator and rotor windings of rotary induction motor and (b winding of primary part of C-LIM (inductor and closed current circuits in external secondary part of C-LIM (race is taken into consideration. The equations of C-LIM mathematical model are presented as matrix together with equations expressing each vector separately. A computational analysis of selected transient states of C-LIM fed via frequency converter is presented in the paper. Two typical examples of C-LIM operation are considered for the analysis: (a starting the motor at various static loads and various synchronous velocities and (b reverse of the motor at the same operation conditions. Results of simulation are presented as transient responses including transient electromagnetic force, transient linear velocity and transient phase current.

Coreless Linear Induction Motor (LIM) for Space-borne Electro-magnetic Mass Driver Applications

Data.gov (United States)

National Aeronautics and Space Administration — Large scale linear induction motors use ferromagnetic cores, but at high speed these cores choke the system’s ability to transform electrical energy into mechanical...

Linear versus non-linear measures of temporal variability in finger tapping and their relation to performance on open- versus closed-loop motor tasks: comparing standard deviations to Lyapunov exponents.

Science.gov (United States)

Christman, Stephen D; Weaver, Ryan

2008-05-01

The nature of temporal variability during speeded finger tapping was examined using linear (standard deviation) and non-linear (Lyapunov exponent) measures. Experiment 1 found that right hand tapping was characterised by lower amounts of both linear and non-linear measures of variability than left hand tapping, and that linear and non-linear measures of variability were often negatively correlated with one another. Experiment 2 found that increased non-linear variability was associated with relatively enhanced performance on a closed-loop motor task (mirror tracing) and relatively impaired performance on an open-loop motor task (pointing in a dark room), especially for left hand performance. The potential uses and significance of measures of non-linear variability are discussed.

Magnetically levitated railway with common reaction rail for a linear motor drive and an electro dynamic side guidance arrangement

Energy Technology Data Exchange (ETDEWEB)

Friedrich, R

1977-04-07

The invention concerns a magnetically levitated railway with common reaction rail for the linear motor drive and the electrical side guidance arrangement. While the electro-dynamic hovering process requires a high electrical conductivity of the reaction rails in order to reduce eddy current losses, these should show a relatively high resistance for the asynchronous linear motor to reduce losses of propelling force. These contradictory requirements can be fulfilled for a common reaction rail made of homogeneous material of high electrical conductivity according to the invention, by providing slits at right angles to the driving axis in the part of the reaction rail allocated to the linear motor. Thus the guidance system retains a low ohmic resistance, while the part of the reaction rail allocated to the windings of the linear motor has a relatively low ohmic secondary resistance, by which the border and end effects which reduce the propelling force can be appreciably reduced.

Current error vector based prediction control of the section winding permanent magnet linear synchronous motor

Energy Technology Data Exchange (ETDEWEB)

Hong Junjie, E-mail: hongjjie@mail.sysu.edu.cn [School of Engineering, Sun Yat-Sen University, Guangzhou 510006 (China); Li Liyi, E-mail: liliyi@hit.edu.cn [Dept. Electrical Engineering, Harbin Institute of Technology, Harbin 150000 (China); Zong Zhijian; Liu Zhongtu [School of Engineering, Sun Yat-Sen University, Guangzhou 510006 (China)

2011-10-15

Highlights: {yields} The structure of the permanent magnet linear synchronous motor (SW-PMLSM) is new. {yields} A new current control method CEVPC is employed in this motor. {yields} The sectional power supply method is different to the others and effective. {yields} The performance gets worse with voltage and current limitations. - Abstract: To include features such as greater thrust density, higher efficiency without reducing the thrust stability, this paper proposes a section winding permanent magnet linear synchronous motor (SW-PMLSM), whose iron core is continuous, whereas winding is divided. The discrete system model of the motor is derived. With the definition of the current error vector and selection of the value function, the theory of the current error vector based prediction control (CEVPC) for the motor currents is explained clearly. According to the winding section feature, the motion region of the mover is divided into five zones, in which the implementation of the current predictive control method is proposed. Finally, the experimental platform is constructed and experiments are carried out. The results show: the current control effect has good dynamic response, and the thrust on the mover remains constant basically.

Innervation zones of fasciculating motor units: observations by a linear electrode array.

Science.gov (United States)

Jahanmiri-Nezhad, Faezeh; Barkhaus, Paul E; Rymer, William Z; Zhou, Ping

2015-01-01

This study examines the innervation zone (IZ) in the biceps brachii muscle in healthy subjects and those with amyotrophic lateral sclerosis (ALS) using a 20-channel linear electromyogram (EMG) electrode array. Raster plots of individual waveform potentials were studied to estimate the motor unit IZ. While this work mainly focused on fasciculation potentials (FPs), a limited number of motor unit potentials (MUPs) from voluntary activity of 12 healthy and seven ALS subjects were also examined. Abnormal propagation of MUPs and scattered IZs were observed in fasciculating units, compared with voluntarily activated MUPs in healthy and ALS subjects. These findings can be related to muscle fiber reinnervation following motor neuron degeneration in ALS and the different origin sites of FPs compared with voluntary MUPs.

Generate stepper motor linear speed profile in real time

Science.gov (United States)

Stoychitch, M. Y.

2018-01-01

In this paper we consider the problem of realization of linear speed profile of stepper motors in real time. We considered the general case when changes of speed in the phases of acceleration and deceleration are different. The new and practical algorithm of the trajectory planning is given. The algorithms of the real time speed control which are suitable for realization to the microcontroller and FPGA circuits are proposed. The practical realization one of these algorithms, using Arduino platform, is given also.

Energetics and efficiency of a molecular motor model

DEFF Research Database (Denmark)

C. Fogedby, Hans; Svane, Axel

2013-01-01

The energetics and efficiency of a linear molecular motor model proposed by Mogilner et al. (Phys. Lett. 237, 297 (1998)) is analyzed from an analytical point of view. The model which is based on protein friction with a track is described by coupled Langevin equations for the motion in combination...... when incorporating the full motor dynamics, owing to the strong dissipation associated with the motor action....

Application of static var compensator on large synchronous motors based on linear optimization control design

International Nuclear Information System (INIS)

Soltani, J.; Fath Abadi, A.M.

2003-01-01

This paper describes the application of static var compensators, on an electrical distribution network containing two large synchronous motors, one of which is excited via a three-phase thyristor bridge rectifier. The second machine is excited via a diode bridge rectifier. Based on linear optimization control, the measurable feedback signals are applied to the control system loops of static var compensators and the excitation control loop of the first synchronous motor. The phase equations method was used to develop a computer program to model the distribution network. Computer results were obtained to demonstrate the system performance for some abnormal modes of operation. These results show that employing static var compensators based on the linear optimization control design for electrical distribution networks containing large synchronous motors is beneficial and may be considered a first stage of the system design

Linear motor driven Stirling coolers for military and commercial applications

International Nuclear Information System (INIS)

Berry, R.

1992-01-01

This paper discusses the design and performance of a miniature, closed cycle, split stirling, cryogenic cooler that provides 1 watt of cooling at 80 K. The compressor uses two opposed linear motors to drive opposed pistons and the expander uses a pneumatically driven displacer. A single electronics module and compressor has been developed to drive three different expanders that have nominal cold cylinder diameters of 5, 8 and 13 mm

International program on linear electric motors

Energy Technology Data Exchange (ETDEWEB)

Dawson, G.E.; Eastham, A.R.; Parker, J.H.

1992-05-01

The International Program on Linear Electric Motors (LEM) was initiated for the purposes of commumication and coordination between various centers of expertise in LEM technology in Germany, Japan and Canada. Furthermore, it was intended to provide assessment and support of the planning of technological developments and for dissemination of information to researchers, service operators and policy makers, and to ensure that full advantage can be taken if opportunities for technology transfer occur. In the process, the program was able to provide closer contacts between researchers, to enhance and encourage collaborative research and development, and to facilitate joint ventures in advanced transportation technologies. Work done under the program is documented, and seminar materials presented by Canadian researchers in Italy, and by Italian researchers at Queen's University in Canada are presented. Five separate abstracts have been prepared for the main body of the report and the seminar materials.

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons.

Science.gov (United States)

Fallini, Claudia; Donlin-Asp, Paul G; Rouanet, Jeremy P; Bassell, Gary J; Rossoll, Wilfried

2016-03-30

Spinal muscular atrophy (SMA) is a neurodegenerative disease primarily affecting spinal motor neurons. It is caused by reduced levels of the survival of motor neuron (SMN) protein, which plays an essential role in the biogenesis of spliceosomal small nuclear ribonucleoproteins in all tissues. The etiology of the specific defects in the motor circuitry in SMA is still unclear, but SMN has also been implicated in mediating the axonal localization of mRNA-protein complexes, which may contribute to the axonal degeneration observed in SMA. Here, we report that SMN deficiency severely disrupts local protein synthesis within neuronal growth cones. We also identify the cytoskeleton-associated growth-associated protein 43 (GAP43) mRNA as a new target of SMN and show that motor neurons from SMA mouse models have reduced levels ofGAP43mRNA and protein in axons and growth cones. Importantly, overexpression of two mRNA-binding proteins, HuD and IMP1, restoresGAP43mRNA and protein levels in growth cones and rescues axon outgrowth defects in SMA neurons. These findings demonstrate that SMN plays an important role in the localization and local translation of mRNAs with important axonal functions and suggest that disruption of this function may contribute to the axonal defects observed in SMA. The motor neuron disease spinal muscular atrophy (SMA) is caused by reduced levels of the survival of motor neuron (SMN) protein, which plays a key role in assembling RNA/protein complexes that are essential for mRNA splicing. It remains unclear whether defects in this well characterized housekeeping function cause the specific degeneration of spinal motor neurons observed in SMA. Here, we describe an additional role of SMN in regulating the axonal localization and local translation of the mRNA encoding growth-associated protein 43 (GAP43). This study supports a model whereby SMN deficiency impedes transport and local translation of mRNAs important for neurite outgrowth and stabilization

A U-shaped linear ultrasonic motor using longitudinal vibration transducers with double feet.

Science.gov (United States)

Liu, Yingxiang; Liu, Junkao; Chen, Weishan; Shi, Shengjun

2012-05-01

A U-shaped linear ultrasonic motor using longitudinal vibration transducers with double feet was proposed in this paper. The proposed motor contains a horizontal transducer and two vertical transducers. The horizontal transducer includes two exponential shape horns located at the leading ends, and each vertical transducer contains one exponential shape horn. The horns of the horizontal transducer and the vertical transducer intersect at the tip ends where the driving feet are located. Longitudinal vibrations are superimposed in the motor and generate elliptical motions at the driving feet. The two vibration modes of the motor are discussed, and the motion trajectories of driving feet are deduced. By adjusting the structural parameters, the resonance frequencies of two vibration modes were degenerated. A prototype motor was fabricated and measured. Typical output of the prototype is no-load speed of 854 mm/s and maximum thrust force of 40 N at a voltage of 200 V(rms).

Optimal design of a double-sided linear motor with a multi-segmented trapezoidal magnet array for a high precision positioning system

International Nuclear Information System (INIS)

Lee, Moon G.; Gweon, Dae-Gab

2004-01-01

A comparative analysis is performed for linear motors adopting conventional and multi-segmented trapezoidal (MST) magnet arrays, respectively, for a high-precision positioning system. The proposed MST magnet array is a modified version of a Halbach magnet array. The MST array has trapezoidal magnets with variable shape and dimensions while the Halbach magnet array generally has a rectangular magnet with identical dimensions. We propose a new model that can describe the magnetic field resulting from the complex-shaped magnets. The model can be applied to both MST and conventional magnet arrays. Using the model, a design optimization of the two types of linear motors is performed and compared. The magnet array with trapezoidal magnets can produce more force than one with rectangular magnets when they are arrayed in a linear motor where there is a yoke with high permeability. After the optimization and comparison, we conclude that the linear motor with the MST magnet array can generate more actuating force per volume than the motor with the conventional array. In order to satisfy the requirements of next generation systems such as high resolution, high speed, and long stroke, the use of a linear motor with a MST array as an actuator in a high precision positioning system is recommended from the results obtained here

Overview of analytical models for the design of linear and planar motors

NARCIS (Netherlands)

Jansen, J.W.; Smeets, J.P.C.; Overboom, T.T.; Rovers, J.M.M.; Lomonova, E.A.

2014-01-01

In this paper, an overview of analytical techniques for the modeling of linear and planar permanent-magnet motors is given. These models can be used complementary to finite element analyses for fast evaluations of topologies, but they are indispensable for the design of magnetically levitated planar

Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy.

Science.gov (United States)

Martinez, Tara L; Kong, Lingling; Wang, Xueyong; Osborne, Melissa A; Crowder, Melissa E; Van Meerbeke, James P; Xu, Xixi; Davis, Crystal; Wooley, Joe; Goldhamer, David J; Lutz, Cathleen M; Rich, Mark M; Sumner, Charlotte J

2012-06-20

The inherited motor neuron disease spinal muscular atrophy (SMA) is caused by deficient expression of survival motor neuron (SMN) protein and results in severe muscle weakness. In SMA mice, synaptic dysfunction of both neuromuscular junctions (NMJs) and central sensorimotor synapses precedes motor neuron cell death. To address whether this synaptic dysfunction is due to SMN deficiency in motor neurons, muscle, or both, we generated three lines of conditional SMA mice with tissue-specific increases in SMN expression. All three lines of mice showed increased survival, weights, and improved motor behavior. While increased SMN expression in motor neurons prevented synaptic dysfunction at the NMJ and restored motor neuron somal synapses, increased SMN expression in muscle did not affect synaptic function although it did improve myofiber size. Together these data indicate that both peripheral and central synaptic integrity are dependent on motor neurons in SMA, but SMN may have variable roles in the maintenance of these different synapses. At the NMJ, it functions at the presynaptic terminal in a cell-autonomous fashion, but may be necessary for retrograde trophic signaling to presynaptic inputs onto motor neurons. Importantly, SMN also appears to function in muscle growth and/or maintenance independent of motor neurons. Our data suggest that SMN plays distinct roles in muscle, NMJs, and motor neuron somal synapses and that restored function of SMN at all three sites will be necessary for full recovery of muscle power.

Dynamic diagnostics of moving ferromagnetic material with the linear induction motor

Directory of Open Access Journals (Sweden)

Szewczyk Krzysztof

2017-01-01

Full Text Available The paper presents the application of a three-phase induction motor as a sensor measuring the force of the electromagnetic field connection between the engine and produced sheet steel. The force interaction between the engine and the manufactured sheet metal treated as a treadmill for a linear motor may be an indicator of damage to the material. Detection of places where the sheet does not meet the quality requirements may be very useful in the production process. FEM calculations were performed in the ANSYS MAXWELL environment. The results suggest the possibility of using this type of construction to test the quality of produced materials. The computational results and their analysis are presented in this article.

Protein Synthesis Inhibition in the Peri-Infarct Cortex Slows Motor Recovery in Rats.

Science.gov (United States)

Schubring-Giese, Maximilian; Leemburg, Susan; Luft, Andreas Rüdiger; Hosp, Jonas Aurel

2016-01-01

Neuroplasticity and reorganization of brain motor networks are thought to enable recovery of motor function after ischemic stroke. Especially in the cortex surrounding the ischemic scar (i.e., peri-infarct cortex), evidence for lasting reorganization has been found at the level of neurons and networks. This reorganization depends on expression of specific genes and subsequent protein synthesis. To test the functional relevance of the peri-infarct cortex for recovery we assessed the effect of protein synthesis inhibition within this region after experimental stroke. Long-Evans rats were trained to perform a skilled-reaching task (SRT) until they reached plateau performance. A photothrombotic stroke was induced in the forelimb representation of the primary motor cortex (M1) contralateral to the trained paw. The SRT was re-trained after stroke while the protein synthesis inhibitor anisomycin (ANI) or saline were injected into the peri-infarct cortex through implanted cannulas. ANI injections reduced protein synthesis within the peri-infarct cortex by 69% and significantly impaired recovery of reaching performance through re-training. Improvement of motor performance within a single training session remained intact, while improvement between training sessions was impaired. ANI injections did not affect infarct size. Thus, protein synthesis inhibition within the peri-infarct cortex impairs recovery of motor deficits after ischemic stroke by interfering with consolidation of motor memory between training sessions but not short-term improvements within one session.

Effect of Frequency and Spatial-Harmonics on Rotary and Linear Induction Motor Characteristics

Science.gov (United States)

1972-03-01

A computer analysis is made of the effect of current and MMF airgap harmonics on the output characteristics of rotary and linear induction motors. The current harmonics accompanying thyristor-control operation are evaluated by Fourier analyzing the p...

Torque decomposition and control in an iron core linear permanent magnet motor.

NARCIS (Netherlands)

Overboom, T.T.; Smeets, J.P.C.; Stassen, J.M.; Jansen, J.W.; Lomonova, E.

2012-01-01

Abstract—This paper concerns the decomposition and control of the torque produced by an iron core linear permanent magnet motor. The proposed method is based on the dq0-decomposition of the three-phase currents using Park’s transformation. The torque is decomposed into a reluctance component and two

Driver electronics design and control for a total artificial heart linear motor.

Science.gov (United States)

Unthan, Kristin; Cuenca-Navalon, Elena; Pelletier, Benedikt; Finocchiaro, Thomas; Steinseifer, Ulrich

2018-01-27

For any implantable device size and efficiency are critical properties. Thus, a linear motor for a Total Artificial Heart was optimized with focus on driver electronics and control strategies. Hardware requirements were defined from power supply and motor setup. Four full bridges were chosen for the power electronics. Shunt resistors were set up for current measurement. Unipolar and bipolar switching for power electronics control were compared regarding current ripple and power losses. Here, unipolar switching showed smaller current ripple and required less power to create the necessary motor forces. Based on calculations for minimal power losses Lorentz force was distributed to the actor's four coils. The distribution was determined as ratio of effective magnetic flux through each coil, which was captured by a force test rig. Static and dynamic measurements under physiological conditions analyzed interaction of control and hardware and all efficiencies were over 89%. In conclusion, the designed electronics, optimized control strategy and applied current distribution create the required motor force and perform optimal under physiological conditions. The developed driver electronics and control offer optimized size and efficiency for any implantable or portable device with multiple independent motor coils. Graphical Abstract ᅟ.

Linearization of the bradford protein assay.

Science.gov (United States)

Ernst, Orna; Zor, Tsaffrir

2010-04-12

Determination of microgram quantities of protein in the Bradford Coomassie brilliant blue assay is accomplished by measurement of absorbance at 590 nm. This most common assay enables rapid and simple protein quantification in cell lysates, cellular fractions, or recombinant protein samples, for the purpose of normalization of biochemical measurements. However, an intrinsic nonlinearity compromises the sensitivity and accuracy of this method. It is shown that under standard assay conditions, the ratio of the absorbance measurements at 590 nm and 450 nm is strictly linear with protein concentration. This simple procedure increases the accuracy and improves the sensitivity of the assay about 10-fold, permitting quantification down to 50 ng of bovine serum albumin. Furthermore, the interference commonly introduced by detergents that are used to create the cell lysates is greatly reduced by the new protocol. A linear equation developed on the basis of mass action and Beer's law perfectly fits the experimental data.

Design and optimization of a modal- independent linear ultrasonic motor.

Science.gov (United States)

Zhou, Shengli; Yao, Zhiyuan

2014-03-01

To simplify the design of the linear ultrasonic motor (LUSM) and improve its output performance, a method of modal decoupling for LUSMs is proposed in this paper. The specific embodiment of this method is decoupling of the traditional LUSM stator's complex vibration into two simple vibrations, with each vibration implemented by one vibrator. Because the two vibrators are designed independently, their frequencies can be tuned independently and frequency consistency is easy to achieve. Thus, the method can simplify the design of the LUSM. Based on this method, a prototype modal- independent LUSM is designed and fabricated. The motor reaches its maximum thrust force of 47 N, maximum unloaded speed of 0.43 m/s, and maximum power of 7.85 W at applied voltage of 200 Vpp. The motor's structure is then optimized by controlling the difference between the two vibrators' resonance frequencies to reach larger output speed, thrust, and power. The optimized results show that when the frequency difference is 73 Hz, the output force, speed, and power reach their maximum values. At the input voltage of 200 Vpp, the motor reaches its maximum thrust force of 64.2 N, maximum unloaded speed of 0.76 m/s, maximum power of 17.4 W, maximum thrust-weight ratio of 23.7, and maximum efficiency of 39.6%.

Spectral element model for 2-D electrostatic fields in a linear synchronous motor

NARCIS (Netherlands)

van Beek, T.A.; Curti, M.; Jansen, J.W.; Gysen, B.L.J.; Paulides, J.J.H.; Lomonova, E.A.

2017-01-01

This paper presents a fast and accurate 2-D spectral element model for analyzing electric field distributions in linear synchronous motors. The electric field distribution is derived using the electric scalar potential for static cases. The spatial potential and electric field distributions obtained

Direct torque and flux regulation of synchronous reluctance motor drives based on input-output feedback linearization

International Nuclear Information System (INIS)

Abootorabi Zarchi, H.; Arab Markadeh, Gh.R.; Soltani, J.

2010-01-01

In this paper, a nonlinear speed tracking controller is introduced for three-phase synchronous reluctance motor (SynRM) on the basis of input-output feedback linearization (IOFL), considering the different control strategies (maximum torque per Ampere, high efficiency and minimum KVA rating for the inverter) related to this motor. The proposed control approach is capable of decoupling control of stator flux and motor generated torque. The validity and effectiveness of the method is verified by simulation and experimental results.

Design and testing of a coaxial linear magnetic spring with integral linear motor. [for spacecraft energy storage

Science.gov (United States)

Patt, P. J.

1985-01-01

The design of a coaxial linear magnetic spring which incorporates a linear motor to control axial motion and overcome system damping is presented, and the results of static and dynamic tests are reported. The system has nominal stiffness 25,000 N/m and is designed to oscillate a 900-g component over a 4.6-mm stroke in a Stirling-cycle cryogenic refrigerator being developed for long-service (5-10-yr) space applications (Stolfi et al., 1983). Mosaics of 10 radially magnetized high-coercivity SmCO5 segments enclosed in Ti cans are employed, and the device is found to have quality factor 70-100, corresponding to energy-storage efficiency 91-94 percent. Drawings, diagrams, and graphs are provided.

A novel tubular linear motor equipped with radially anisotropic NdFeB ring magnets

International Nuclear Information System (INIS)

Hor, P.J.

1998-01-01

The paper describes the design synthesis and optimisation of a novel tubular linear motor employing radially magnetised anisotropic ring magnets. Design issues, related to optimising the dimensions for maximum acceleration capability, minimum cogging force and low harmonic distortion in the emf waveform, are discussed. The influence of inhomogeneities in the magnets on the performance of a prototype motor is discussed, and its dynamic performance is validated experimentally against a typical target specification for automated high-speed manufacturing applications. (orig.)

Linear magnetic motor/generator. [to generate electric energy using magnetic flux for spacecraft power supply

Science.gov (United States)

Studer, P. A. (Inventor)

1982-01-01

A linear magnetic motor/generator is disclosed which uses magnetic flux to provide mechanical motion or electrical energy. The linear magnetic motor/generator includes an axially movable actuator mechanism. A permament magnet mechanism defines a first magnetic flux path which passes through a first end portion of the actuator mechanism. Another permament magnet mechanism defines a second magnetic flux path which passes through a second end portion of the actuator mechanism. A drive coil defines a third magnetic flux path passing through a third central portion of the actuator mechanism. A drive coil selectively adds magnetic flux to and subtracts magnetic flux from magnetic flux flowing in the first and second magnetic flux path.

Development of an ultrasonic linear motor with ultra-positioning capability and four driving feet.

Science.gov (United States)

Zhu, Cong; Chu, Xiangcheng; Yuan, Songmei; Zhong, Zuojin; Zhao, Yanqiang; Gao, Shuning

2016-12-01

This paper presents a novel linear piezoelectric motor which is suitable for rapid ultra-precision positioning. The finite element analysis (FEA) was applied for optimal design and further analysis, then experiments were conducted to investigate its performance. By changing the input signal, the proposed motor was found capable of working in the fast driving mode as well as in the precision positioning mode. When working in the fast driving mode, the motor acts as an ultrasonic motor with maximum no-load speed up to 181.2mm/s and maximum thrust of 1.7N at 200Vp-p. Also, when working in precision positioning mode, the motor can be regarded as a flexible hinge piezoelectric actuator with arbitrary motion in the range of 8μm. The measurable minimum output displacement was found to be 0.08μm, but theoretically, can be even smaller. More importantly, the motor can be quickly and accurately positioned in a large stroke. Copyright © 2016 Elsevier B.V. All rights reserved.

Generating linear regression model to predict motor functions by use of laser range finder during TUG.

Science.gov (United States)

Adachi, Daiki; Nishiguchi, Shu; Fukutani, Naoto; Hotta, Takayuki; Tashiro, Yuto; Morino, Saori; Shirooka, Hidehiko; Nozaki, Yuma; Hirata, Hinako; Yamaguchi, Moe; Yorozu, Ayanori; Takahashi, Masaki; Aoyama, Tomoki

2017-05-01

The purpose of this study was to investigate which spatial and temporal parameters of the Timed Up and Go (TUG) test are associated with motor function in elderly individuals. This study included 99 community-dwelling women aged 72.9 ± 6.3 years. Step length, step width, single support time, variability of the aforementioned parameters, gait velocity, cadence, reaction time from starting signal to first step, and minimum distance between the foot and a marker placed to 3 in front of the chair were measured using our analysis system. The 10-m walk test, five times sit-to-stand (FTSTS) test, and one-leg standing (OLS) test were used to assess motor function. Stepwise multivariate linear regression analysis was used to determine which TUG test parameters were associated with each motor function test. Finally, we calculated a predictive model for each motor function test using each regression coefficient. In stepwise linear regression analysis, step length and cadence were significantly associated with the 10-m walk test, FTSTS and OLS test. Reaction time was associated with the FTSTS test, and step width was associated with the OLS test. Each predictive model showed a strong correlation with the 10-m walk test and OLS test (P motor function test. Moreover, the TUG test time regarded as the lower extremity function and mobility has strong predictive ability in each motor function test. Copyright © 2017 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

Electrohydraulic linear actuator with two stepping motors controlled by overshoot-free algorithm

Science.gov (United States)

Milecki, Andrzej; Ortmann, Jarosław

2017-11-01

The paper describes electrohydraulic spool valves with stepping motors used as electromechanical transducers. A new concept of a proportional valve in which two stepping motors are working differentially is introduced. Such valve changes the fluid flow proportionally to the sum or difference of the motors' steps numbers. The valve design and principle of its operation is described. Theoretical equations and simulation models are proposed for all elements of the drive, i.e., the stepping motor units, hydraulic valve and cylinder. The main features of the valve and drive operation are described; some specific problem areas covering the nature of stepping motors and their differential work in the valve are also considered. The whole servo drive non-linear model is proposed and used further for simulation investigations. The initial simulation investigations of the drive with a new valve have shown that there is a significant overshoot in the drive step response, which is not allowed in positioning process. Therefore additional effort is spent to reduce the overshoot and in consequence reduce the settling time. A special predictive algorithm is proposed to this end. Then the proposed control method is tested and further improved in simulations. Further on, the model is implemented in reality and the whole servo drive system is tested. The investigation results presented in this paper, are showing an overshoot-free positioning process which enables high positioning accuracy.

The linear electric motor: Instability at 1,000 g's

International Nuclear Information System (INIS)

Hunter, S.

1997-01-01

When fluid of high density is supported against gravity by a less dense liquid, the system is unstable, and microscopic perturbations grow at the interface between the fluids. This phenomenon, called the Rayleigh-Taylor instability, also occurs when a bottle of oil-and-vinegar salad dressing is turned upside down. The instability causes spikes of the dense fluid to penetrate the light fluid, while bubbles of the lighter fluid rise into the dense fluid. The same phenomenon occurs when a light fluid is used to accelerate a dense fluid, causing the two fluids to mix at a very high rate. For example, during the implosion of an ICF capsule, this instability can cause enough mixing to contaminate, cool, and degrade the yield of the thermonuclear fuel. The LEM is an excellent tool for studying this instability, but what is it? Think of a miniature high-speed electric train (the container) hurtling down a track (the electrodes) while diagnostic equipment (optical and laser) photographs it. The LEM, consists of four linear electrodes, or rails, that carry an electrical current to a pair of sliding armatures on the container. A magnetic field is produced that works in concert with the rail-armature current to accelerate the container--just as in an electric motor, but in a linear fashion rather than in rotation. The magnetic field is augmented with elongated coils just as in a conventional electric motor. This configuration also helps hold the armatures against the electrodes to prevent arcing. The electrical energy (0.6 megajoules) is provided by 16 capacitor banks that can be triggered independently to produce different acceleration profiles (i.e., how the acceleration varies with time)

Modeling and experimental analysis of the linear ultrasonic motor with in-plane bending and longitudinal mode.

Science.gov (United States)

Wan, Zhijian; Hu, Hong

2014-03-01

A novel linear ultrasonic motor based on in-plane longitudinal and bending mode vibration is presented in this paper. The stator of the motor is composed of a metal plate and eight piezoelectric ceramic patches. There are four long holes in the plate, designed for consideration of the longitudinal and bending mode coupling. The corresponding model is developed to optimize the mechanical and electrical coupling of the stator, which causes an ellipse motion at the contact tip of the stator when the composite vibrations with longitudinal and bending are excited. Its harmonic and transient responses are simulated and inspected. A prototype based on the model is fabricated and used to conduct experiments. Results show that the amplitude of the stator's contact tips is significantly increased, which helps to amplify the driving force and speed of the motor. It is therefore feasible to implement effective linear movement using the developed prototype. Copyright © 2013 Elsevier B.V. All rights reserved.

Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions.

Science.gov (United States)

Chemes, Lucía Beatriz; de Prat-Gay, Gonzalo; Sánchez, Ignacio Enrique

2015-06-01

Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functional output of a mimic depends on the motif and domain repertoire of the pathogen protein. Regulatory evolution mediated by linear motifs can be understood by measuring evolutionary rates, quantifying positive and negative selection and performing phylogenetic reconstructions of linear motif natural history. Convergent evolution of linear motif mimics is widespread among unrelated proteins from viral, prokaryotic and eukaryotic pathogens and can also take place within individual protein phylogenies. Statistics, biochemistry and laboratory models of infection link pathogen linear motifs to phenotypic traits such as tropism, virulence and oncogenicity. In vitro evolution experiments and analysis of natural sequences suggest that changes in linear motif composition underlie pathogen adaptation to a changing environment. Copyright © 2015 Elsevier Ltd. All rights reserved.

Bond Graph Modelling for Fault Detection and Isolation of an Ultrasonic Linear Motor

Directory of Open Access Journals (Sweden)

Mabrouk KHEMLICHE

2010-12-01

Full Text Available In this paper Bond Graph modeling, simulation and monitoring of ultrasonic linear motors are presented. Only the vibration of piezoelectric ceramics and stator will be taken into account. Contact problems between stator and rotor are not treated here. So, standing and travelling waves will be briefly presented since the majority of the motors use another wave type to generate the stator vibration and thus obtain the elliptic trajectory of the points on the surface of the stator in the first time. Then, electric equivalent circuit will be presented with the aim for giving a general idea of another way of graphical modelling of the vibrator introduced and developed. The simulations of an ultrasonic linear motor are then performed and experimental results on a prototype built at the laboratory are presented. Finally, validation of the Bond Graph method for modelling is carried out, comparing both simulation and experiment results. This paper describes the application of the FDI approach to an electrical system. We demonstrate the FDI effectiveness with real data collected from our automotive test. We introduce the analysis of the problem involved in the faults localization in this process. We propose a method of fault detection applied to the diagnosis and to determine the gravity of a detected fault. We show the possibilities of application of the new approaches to the complex system control.

Decreased function of survival motor neuron protein impairs endocytic pathways.

Science.gov (United States)

Dimitriadi, Maria; Derdowski, Aaron; Kalloo, Geetika; Maginnis, Melissa S; O'Hern, Patrick; Bliska, Bryn; Sorkaç, Altar; Nguyen, Ken C Q; Cook, Steven J; Poulogiannis, George; Atwood, Walter J; Hall, David H; Hart, Anne C

2016-07-26

Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a disease allele. SMN is critical for the assembly of numerous ribonucleoprotein complexes, yet it is still unclear how reduced SMN levels affect motor neuron function. Here, we examined the impact of SMN depletion in Caenorhabditis elegans and found that decreased function of the SMN ortholog SMN-1 perturbed endocytic pathways at motor neuron synapses and in other tissues. Diminished SMN-1 levels caused defects in C. elegans neuromuscular function, and smn-1 genetic interactions were consistent with an endocytic defect. Changes were observed in synaptic endocytic proteins when SMN-1 levels decreased. At the ultrastructural level, defects were observed in endosomal compartments, including significantly fewer docked synaptic vesicles. Finally, endocytosis-dependent infection by JC polyomavirus (JCPyV) was reduced in human cells with decreased SMN levels. Collectively, these results demonstrate for the first time, to our knowledge, that SMN depletion causes defects in endosomal trafficking that impair synaptic function, even in the absence of motor neuron cell death.

NASTRAN buckling study of a linear induction motor reaction rail

Science.gov (United States)

Williams, J. G.

1973-01-01

NASTRAN was used to study problems associated with the installation of a linear induction motor reaction rail test track. Specific problems studied include determination of the critical axial compressive buckling stress and establishment of the lateral stiffness of the reaction rail under combined loads. NASTRAN results were compared with experimentally obtained values and satisfactory agreement was obtained. The reaction rail was found to buckle at an axial compressive stress of 11,400 pounds per square inch. The results of this investigation were used to select procedures for installation of the reaction rail.

Computation of magnetic field in DC brushless linear motors built with NdFeB magnets

International Nuclear Information System (INIS)

Basak, A.; Shirkoohi, G.H.

1990-01-01

A software package based on finite element technique has been used to compute three-dimensional magnetic fields and static forces developed in brushless d.c. linear motors. As the field flux-source two different types of permanent magnets, one of them being the high energy neodymium- iron-boron type, has been used in computer models. Motors with the same specifications as the computer models were built and experimental results obtained from them are compared with the computed results

Flux modeling and analysis of a linear induction motor for steel mill non-contacting conveyance system application

International Nuclear Information System (INIS)

Liu, C.-T.; Lin, S.-Y.; Yang, Y.-Y.

2005-01-01

A detailed mathematical approach for analyzing static/dynamic characteristics of a linear induction motor for steel mill non-contacting conveyance system application will be provided. The dependent reluctances among the motor secondary steel plate and primary poles have been systematically formulated; hence, the operational performance of the system can be derived conveniently. Results showed that not only the motor structure is suitable for the design objective, but also the proposed magnetic equivalent circuit can provide appropriate and convenient modeling for relative analytical investigations

Inertial piezoelectric linear motor driven by a single-phase harmonic wave with automatic clamping mechanism

Science.gov (United States)

He, Liangguo; Chu, Yuheng; Hao, Sai; Zhao, Xiaoyong; Dong, Yuge; Wang, Yong

2018-05-01

A novel, single-phase, harmonic-driven, inertial piezoelectric linear motor using an automatic clamping mechanism was designed, fabricated, and tested to reduce the sliding friction and simplify the drive mechanism and power supply control of the inertial motor. A piezoelectric bimorph and a flexible hinge were connected in series to form the automatic clamping mechanism. The automatic clamping mechanism was used as the driving and clamping elements. A dynamic simulation by Simulink was performed to prove the feasibility of the motor. The finite element method software COMSOL was used to design the structure of the motor. An experimental setup was built to validate the working principle and evaluate the performance of the motor. The prototype motor outputted a no-load velocity of 3.178 mm/s at a voltage of 220 Vp-p and a maximum traction force of 4.25 N under a preload force of 8 N. The minimum resolution of 1.14 μm was achieved at a driving frequency of 74 Hz, a driving voltage of 50 Vp-p, and a preload force of 0 N.

Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein.

Science.gov (United States)

Banerjee, Rupa; Gladkova, Christina; Mapa, Koyeli; Witte, Gregor; Mokranjac, Dejana

2015-12-29

The majority of mitochondrial proteins are targeted to mitochondria by N-terminal presequences and use the TIM23 complex for their translocation across the mitochondrial inner membrane. During import, translocation through the channel in the inner membrane is coupled to the ATP-dependent action of an Hsp70-based import motor at the matrix face. How these two processes are coordinated remained unclear. We show here that the two domain structure of Tim44 plays a central role in this process. The N-terminal domain of Tim44 interacts with the components of the import motor, whereas its C-terminal domain interacts with the translocation channel and is in contact with translocating proteins. Our data suggest that the translocation channel and the import motor of the TIM23 complex communicate through rearrangements of the two domains of Tim44 that are stimulated by translocating proteins.

Correlations and symmetry of interactions influence collective dynamics of molecular motors

International Nuclear Information System (INIS)

Celis-Garza, Daniel; Teimouri, Hamid; Kolomeisky, Anatoly B

2015-01-01

Enzymatic molecules that actively support many cellular processes, including transport, cell division and cell motility, are known as motor proteins or molecular motors. Experimental studies indicate that they interact with each other and they frequently work together in large groups. To understand the mechanisms of collective behavior of motor proteins we study the effect of interactions in the transport of molecular motors along linear filaments. It is done by analyzing a recently introduced class of totally asymmetric exclusion processes that takes into account the intermolecular interactions via thermodynamically consistent approach. We develop a new theoretical method that allows us to compute analytically all dynamic properties of the system. Our analysis shows that correlations play important role in dynamics of interacting molecular motors. Surprisingly, we find that the correlations for repulsive interactions are weaker and more short-range than the correlations for the attractive interactions. In addition, it is shown that symmetry of interactions affect dynamic properties of molecular motors. The implications of these findings for motor proteins transport are discussed. Our theoretical predictions are tested by extensive Monte Carlo computer simulations. (paper)

Design and characterization of a microelectromechanical system electro-thermal linear motor with interlock mechanism for micro manipulators.

Science.gov (United States)

Hu, Tengjiang; Zhao, Yulong; Li, Xiuyuan; Zhao, You; Bai, Yingwei

2016-03-01

The design, fabrication, and testing of a novel electro-thermal linear motor for micro manipulators is presented in this paper. The V-shape electro-thermal actuator arrays, micro lever, micro spring, and slider are introduced. In moving operation, the linear motor can move nearly 1 mm displacement with 100 μm each step while keeping the applied voltage as low as 17 V. In holding operation, the motor can stay in one particular position without consuming energy and no creep deformation is found. Actuation force of 12.7 mN indicates the high force generation capability of the device. Experiments of lifetime show that the device can wear over two million cycles of operation. A silicon-on-insulator wafer is introduced to fabricate a high aspect ratio structure and the chip size is 8.5 mm × 8.5 mm × 0.5 mm.

Mass distribution and spatial organization of the linear bacterial motor of Spiroplasma citri R8A2.

Science.gov (United States)

Trachtenberg, Shlomo; Andrews, S Brian; Leapman, Richard D

2003-03-01

In the simple, helical, wall-less bacterial genus Spiroplasma, chemotaxis and motility are effected by a linear, contractile motor arranged as a flat cytoskeletal ribbon attached to the inner side of the membrane along the shortest helical line. With scanning transmission electron microscopy and diffraction analysis, we determined the hierarchical and spatial organization of the cytoskeleton of Spiroplasma citri R8A2. The structural unit appears to be a fibril, approximately 5 nm wide, composed of dimers of a 59-kDa protein; each ribbon is assembled from seven fibril pairs. The functional unit of the intact ribbon is a pair of aligned fibrils, along which pairs of dimers form tetrameric ring-like repeats. On average, isolated and purified ribbons contain 14 fibrils or seven well-aligned fibril pairs, which are the same structures observed in the intact cell. Scanning transmission electron microscopy mass analysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis of purified cytoskeletons indicate that the 59-kDa protein is the only constituent of the ribbons.

A rectangle-type linear ultrasonic motor using longitudinal vibration transducers with four driving feet.

Science.gov (United States)

Liu, Yingxiang; Chen, Weishan; Liu, Junkao; Shi, Shengjun

2013-04-01

To make full use of the vibrational energy of a longitudinal transducer, a rectangle-type linear ultrasonic motor with four driving feet is proposed in this paper. This new motor consists of four longitudinal vibration transducers which are arranged in a rectangle and form an enclosed construction. Lead zirconate titanate ceramics are embedded into the middle of the transducer and fastened by a wedge-caulking mechanism. Each transducer includes an exponentially shaped horn located on each end. The horns of the vertical transducers intersect at the base of the horizontal transducers' horns; the tip ends of the horizontal transducers' horns are used as the driving feet. Longitudinal vibrations are superimposed in the motor and generate elliptical movements at the tip ends of the horns. The working principle of the proposed motor is analyzed. The resonance frequencies of two working modes are tuned to be close to each other by adjusting the structural parameters. Transient analysis is developed to gain the vibration characteristics of the motor. A prototype motor is fabricated and measured. The vibration test results verify the feasibility of the proposed design. Typical output of the prototype is a no-load speed of 928 mm/s and maximum thrust force of 60 N at a voltage of 200 Vrms.

Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots.

Science.gov (United States)

Kakizuka, Taishi; Ikezaki, Keigo; Kaneshiro, Junichi; Fujita, Hideaki; Watanabe, Tomonobu M; Ichimura, Taro

2016-07-01

Simultaneous nanometric tracking of multiple motor proteins was achieved by combining multicolor fluorescent labeling of target proteins and imaging spectroscopy, revealing dynamic behaviors of multiple motor proteins at the sub-diffraction-limit scale. Using quantum dot probes of distinct colors, we experimentally verified the localization precision to be a few nanometers at temporal resolution of 30 ms or faster. One-dimensional processive movement of two heads of a single myosin molecule and multiple myosin molecules was successfully traced. Furthermore, the system was modified for two-dimensional measurement and applied to tracking of multiple myosin molecules. Our approach is useful for investigating cooperative movement of proteins in supramolecular nanomachinery.

Analysis and Design of a Maglev Permanent Magnet Synchronous Linear Motor to Reduce Additional Torque in dq Current Control

Directory of Open Access Journals (Sweden)

Feng Xing

2018-03-01

Full Text Available The maglev linear motor has three degrees of motion freedom, which are respectively realized by the thrust force in the x-axis, the levitation force in the z-axis and the torque around the y-axis. Both the thrust force and levitation force can be seen as the sum of the forces on the three windings. The resultant thrust force and resultant levitation force are independently controlled by d-axis current and q-axis current respectively. Thus, the commonly used dq transformation control strategy is suitable for realizing the control of the resultant force, either thrust force and levitation force. However, the forces on the three windings also generate additional torque because they do not pass the mover mass center. To realize the maglev system high-precision control, a maglev linear motor with a new structure is proposed in this paper to decrease this torque. First, the electromagnetic model of the motor can be deduced through the Lorenz force formula. Second, the analytic method and finite element method are used to explore the reason of this additional torque and what factors affect its change trend. Furthermore, a maglev linear motor with a new structure is proposed, with two sets of 90 degrees shifted winding designed on the mover. Under such a structure, the mover position dependent periodic part of the additional torque can be offset. Finally, the theoretical analysis is validated by the simulation result that the additionally generated rotating torque can be offset with little fluctuation in the proposed new-structure maglev linear motor. Moreover, the control system is built in MATLAB/Simulink, which shows that it has small thrust ripple and high-precision performance.

Application of an imperialist competitive algorithm to the design of a linear induction motor

International Nuclear Information System (INIS)

Lucas, Caro; Nasiri-Gheidari, Zahra; Tootoonchian, Farid

2010-01-01

In this paper a novel optimization algorithm based on imperialist competitive algorithm (ICA) is used for the design of a low speed single sided linear induction motor (LIM). This type of motors is used increasingly in industrial process specially in transportation systems. In these applications having high efficiency with high power factor is very important. So in this paper the objective function of design is presented considering both efficiency and power factor. Finally the results of ICA are compared with the ones of genetic algorithm and conventional design. Comparison shows the success of ICA for design of LIMs.

Energetics and efficiency of a molecular motor model

International Nuclear Information System (INIS)

Fogedby, Hans C; Svane, Axel

2013-01-01

The energetics and efficiency of a linear molecular motor model proposed by Mogilner et al are analyzed from an analytical point of view. The model, which is based on protein friction with a track, is described by coupled Langevin equations for the motion in combination with coupled master equations for the ATP hydrolysis. Here the energetics and efficiency of the motor are addressed using a many body scheme with focus on the efficiency at maximum power (EMP). It is found that the EMP is reduced from about 10% in a heuristic description of the motor to about 1 per mille when incorporating the full motor dynamics, owing to the strong dissipation associated with the motor action. (paper)

Adaptive H∞ nonlinear velocity tracking using RBFNN for linear DC brushless motor

Science.gov (United States)

Tsai, Ching-Chih; Chan, Cheng-Kain; Li, Yi Yu

2012-01-01

This article presents an adaptive H ∞ nonlinear velocity control for a linear DC brushless motor. A simplified model of this motor with friction is briefly recalled. The friction dynamics is described by the Lu Gre model and the online tuning radial basis function neural network (RBFNN) is used to parameterise the nonlinear friction function and un-modelled errors. An adaptive nonlinear H ∞ control method is then proposed to achieve velocity tracking, by assuming that the upper bounds of the ripple force, the changeable load and the nonlinear friction can be learned by the RBFNN. The closed-loop system is proven to be uniformly bounded using the Lyapunov stability theory. The feasibility and the efficacy of the proposed control are exemplified by conducting two velocity tracking experiments.

An electrostatic 3-phase linear stepper motor fabricated by vertical trench isolation technology

International Nuclear Information System (INIS)

Sarajlic, Edin; Yamahata, Christophe; Cordero, Mauricio; Fujita, Hiroyuki

2009-01-01

We present the design, microfabrication and characterization of an electrostatic 3-phase linear stepper micromotor constructed with vertical trench isolation technology. This suitable technology was used to create a monolithic stepper motor with high-aspect-ratio poles and an integrated 3-phase electrical network in the bulk of a standard single-crystal silicon wafer. The shuttle of the stepper motor is suspended by a flexure to avoid any mechanical contact during operation, enhancing the precision, repeatability and reliability of the stepping motion. The prototype is capable of a maximum travel of +/−26 µm (52 µm) at an actuation voltage of 30 V and a step size of 1.4 µm during a half-stepping sequence

A study of thermal deformation in the carriage of a permanent magnet direct drive linear motor stage

International Nuclear Information System (INIS)

Chow, J.H.; Zhong, Z.W.; Lin, W.; Khoo, L.P.

2012-01-01

Carriage deformation due to temperature gradients within the materials of the carriage affects the accuracy of precision machines. This is largely due to the indeterminist temperature distribution in the carriage's material caused by the non-linearity of heat transfer. The joule heat from the motor coil forms the main heat source. When coupled with the heat loss through convection and radiation, the temperature variation in the motor's carriage also increases. In this study, the Finite Element Analysis was used together with a set of boundary conditions, which was obtained empirically, to analyze the distortion of the motor's carriage. The simulated results were compared with those obtained through experiments. The study shows that it is important to know, rather than to assume, the thermal boundary conditions of the motor's carriage of a precision machine in order to accurately estimate the thermal deformation of the carriage in precision machining. - Highlights: ► Deformation occurs in carriages which are mounted with linear motor. ► The convective coefficient, which is assumed to be 10 W mm −2 , is shown to be invalid. ► The perfect contact conductance is shown to be invalid too. ► To have an accurate thermal model, boundary conditions have to be realistic. ► Boundary conditions are the heat source, convective and conductance values.

Speed Sensorless mixed sensitivity linear parameter variant H_inf control of the induction motor

NARCIS (Netherlands)

Toth, R.; Fodor, D.

2004-01-01

The paper shows the design of a robust control structure for the speed sensorless vector control of the IM, based on the mixed sensitivity (MS) linear parameter variant (LPV) H8 control theory. The controller makes possible the direct control of the flux and speed of the motor with torque adaptation

A new double sided linear switched reluctance motor with low cost

International Nuclear Information System (INIS)

Daldaban, Ferhat; Ustkoyuncu, Nurettin

2006-01-01

This paper presents the realization and design of a new linear switched reluctance motor (LSRM) structure. The new model has double sided configuration and provides high force for many applications with low cost. The characteristics of the LSRM are obtained by using finite element analysis (FEA) and analytical calculations. The results of the FEA and analytical calculations are presented, and compared with experimental results. A high correlation between experimental and analytical results is obtained, which has been demonstrated in the form of inductance versus position versus current

Decentralized control of the COFS-I Mast using linear dc motors

Science.gov (United States)

Lindner, Douglas K.; Celano, Tom; Ide, Eric

1989-01-01

Consideration is given to a decentralized control design for vibration suppression in the COFS-I Mast using linear dc motors for actuators. The decentralized control design is based results from power systems using root locus techniques that are not well known. The approach is effective because the loop gain is low due to low actuator authority. The frequency-dependent nonlinearities of the actuator are taken into account. Because of the tendency of the transients to saturate the the stroke length of the actuator, its effectiveness is limited.

H-Shaped Multiple Linear Motor Drive Platform Control System Design Based on an Inverse System Method

Directory of Open Access Journals (Sweden)

Caiyan Qin

2017-12-01

Full Text Available Due to its simple mechanical structure and high motion stability, the H-shaped platform has been increasingly widely used in precision measuring, numerical control machining and semiconductor packaging equipment, etc. The H-shaped platform is normally driven by multiple (three permanent magnet synchronous linear motors. The main challenges for H-shaped platform-control include synchronous control between the two linear motors in the Y direction as well as total positioning error of the platform mover, a combination of position deviation in X and Y directions. To deal with the above challenges, this paper proposes a control strategy based on the inverse system method through state feedback and dynamic decoupling of the thrust force. First, mechanical dynamics equations have been deduced through the analysis of system coupling based on the platform structure. Second, the mathematical model of the linear motors and the relevant coordinate transformation between dq-axis currents and ABC-phase currents are analyzed. Third, after the main concept of inverse system method being explained, the inverse system model of the platform control system has been designed after defining relevant system variables. Inverse system model compensates the original nonlinear coupled system into pseudo-linear decoupled linear system, for which typical linear control methods, like PID, can be adopted to control the system. The simulation model of the control system is built in MATLAB/Simulink and the simulation result shows that the designed control system has both small synchronous deviation and small total trajectory tracking error. Furthermore, the control program has been run on NI controller for both fixed-loop-time and free-loop-time modes, and the test result shows that the average loop computation time needed is rather small, which makes it suitable for real industrial applications. Overall, it proves that the proposed new control strategy can be used in

Simplified 3D Finite Element Analysis of Linear Inductor Motor for Integrated Magnetic Suspension/Propulsion Applications

Energy Technology Data Exchange (ETDEWEB)

Jeong, Sang Sub; Jang Seok Myeong [Chungnam National University(Korea)

2000-06-01

The 4-pole linear homopolar synchronous motor (LHSM), so called linear inductor motor, is composed of the figure-of-eight shaped 3-phase armature windings, DC field windings, and the segmented secondary with the transverse bar track. To reduce the calculation time, the simplified 3D finite element model with equivalent reluctance and/or permanent magnet is presented. To obtain a clear understanding, propriety and usefulness of the developed mode., we compare with the results of simplified 3D FEA and test. Consequently, the results of simplified and 3D FEM analysis are nearly identical, but much larger than that of static test at d-axis armature excitation. Therefore the improved FEA model, such as full model with half slot, is needed for the precise analysis. (author). refs., figs., tabs.

A descrição do funcionamento de um motor Homopolar linear e suas aplicações: Ilustrando o funcionamento de um acelerador de partículas

OpenAIRE

Doff, Adriano; Szmoski, Romeu M.

2016-01-01

Neste trabalho exploramos o potencial didático de um motor homopolar linear com o objetivo de ilustrar o princípio de funcionamento de um acelerador de partículas. A fim de estabelecer o mecanismo de funcionamento de um motor homopolar linear, consideramos uma analogia com a descrição de um motor homopolar rotatório, e partir deste apresentamos os princípios de funcionamento deste dispositivo e estabelecemos um limite teórico para a velocidade do motor linear. De posse dos dados gerados exper...

A simplified tether model for molecular motor transporting cargo

International Nuclear Information System (INIS)

Fang-Zhen, Li; Li-Chun, Jiang

2010-01-01

Molecular motors are proteins or protein complexes which function as transporting engines in biological cells. This paper models the tether between motor and its cargo as a symmetric linear potential. Different from Elston and Peskin's work for which performance of the system was discussed only in some limiting cases, this study produces analytic solutions of the problem for general cases by simplifying the transport system into two physical states, which makes it possible to discuss the dynamics of the motor–cargo system in detail. It turns out that the tether strength between motor and cargo should be greater than a threshold or the motor will fail to transport the cargo, which was not discussed by former researchers yet. Value of the threshold depends on the diffusion coefficients of cargo and motor and also on the strength of the Brownian ratchets dragging the system. The threshold approaches a finite constant when the strength of the ratchet tends to infinity. (general)

Vibration Analysis and Experimental Research of the Linear-Motor-Driven Water Piston Pump Used in the Naval Ship

Directory of Open Access Journals (Sweden)

Ye-qing Huang

2016-01-01

Full Text Available Aiming at the existing problems of traditional water piston pump used in the naval ship, such as low efficiency, high noise, large vibration, and nonintelligent control, a new type of linear-motor-driven water piston pump is developed and its vibration characteristics are analyzed in this research. Based on the 3D model of the structure, the simulation analyses including static stress analysis, modal analysis, and harmonic response analysis are conducted. The simulation results reveal that the mode shape under low frequency stage is mainly associated with the eccentricity swing of the piston rod. The vibration experiment results show that the resonance frequency of linear-motor-driven water piston pump is concentrated upon 500 Hz and 800 Hz in the low frequency range. The dampers can change the resonance frequency of the system to a certain extent. The vibration under triangular motion curve is much better than that of S curve, which is consistent with the simulation conclusion. This research provides an effective method to detect the vibration characteristics and a reference for design and optimization of the linear-motor-driven water piston pump.

A linear motor and compact cylinder-piston driver for left ventricular bypass.

Science.gov (United States)

Qian, K X

1990-01-01

A simple, portable, reliable and noise-free pneumatic driver has been developed. It consists of a linear motor attached to a cylinder piston, in one unit. The motor coil is directly wound on the cylinder, and the permanent magnet is fixed to the piston. As a continuous voltage square wave is applied to the coil, the cylinder reciprocates on the piston periodically, producing air pressure and vacuum alternately. In conjunction with a locally made diaphragm pump, the driver was tested in vitro and in vivo. Results demonstrated that the device could drive the diaphragm pump and so support the circulation of an experimental animal. The driver weighs 12 kg. For 200 mmHg air pressure and -80 mmHg vacuum the power consumed is 30 W. Its noise is about 30 dB, less than that of an artificial valve and pump.

Novel Synchronous Linear and Rotatory Micro Motors Based on Polymer Magnets with Organic and Inorganic Insulation Layers

Directory of Open Access Journals (Sweden)

Andreas WALDSCHIK

2008-12-01

Full Text Available In this work, we report on the development of several synchronous motors with rotatory or linear movements. The synchronous micro motors are brushless DC motors or stepper motors with electrically controlled commutation consisting of a stator and a rotor. The rotor is mounted onto the stator and is adjusted by an integrated guidance. Inside the stator different coil systems are realized, like double layer sector coils or special nested coils. The coil systems can be controlled by three or six phases depending on the operational mode. Furthermore, inorganic insulation layers were used in order to reduce the thickness of the system. By this means four layers of electrical conductors can be realized especially for the 2D devices. The smallest diameter of the rotatory motor is 1 mm and could be successfully driven.

A novel large thrust-weight ratio V-shaped linear ultrasonic motor with a flexible joint.

Science.gov (United States)

Li, Xiaoniu; Yao, Zhiyuan; Yang, Mojian

2017-06-01

A novel large thrust-weight ratio V-shaped linear ultrasonic motor with a flexible joint is proposed in this paper. The motor is comprised of a V-shaped transducer, a slider, a clamp, and a base. The V-shaped transducer consists of two piezoelectric beams connected through a flexible joint to form an appropriate coupling angle. The V-shaped motor is operated in the coupled longitudinal-bending mode. Longitudinal and bending movements are transferred by the flexible joint between the two beams. Compared with the coupled longitudinal-bending mode of the single piezoelectric beam or the symmetrical and asymmetrical modes of the previous V-shaped transducer, the coupled longitudinal-bending mode of the V-shaped transducer with a flexible joint provides higher vibration efficiency and more convenient mode conformance adjustment. A finite element model of the V-shaped transducer is created to numerically study the influence of geometrical parameters and to determine the final geometrical parameters. In this paper, three prototypes were then fabricated and experimentally investigated. The modal test results match well with the finite element analysis. The motor mechanical output characteristics of three different coupling angles θ indicate that V-90 (θ = 90°) is the optimal angle. The mechanical output experiments conducted using the V-90 prototype (Size: 59.4 mm × 30.7 mm × 4 mm) demonstrate that the maximum unloaded speed is 1.2 m/s under a voltage of 350 Vpp, and the maximum output force is 15 N under a voltage of 300 Vpp. The proposed novel V-shaped linear ultrasonic motor has a compact size and a simple structure with a large thrust-weight ratio (0.75 N/g) and high speed.

Reciprocating Linear Electric Motor

Science.gov (United States)

Goldowsky, M. P.

1984-01-01

Features include structural simplicity and good force/displacement characteristics. Reciprocating motor has simple, rugged construction, relatively low reciprocating weight, improved power delivery, and improved force control. Wear reduced by use of magnetic bearings. Intended to provide drivers for long-lived Stirling-cycle cryogenic refrigerators, concept has less exotic applications, such as fuel pumps.

Evaluation of linear DC motor actuators for control of large space structures

OpenAIRE

Ide, Eric Nelson

1988-01-01

This thesis examines the use of a linear DC motor as a proof mass actuator for the control of large space structures. A model for the actuator, including the current and force compensation used, is derived. Because of the force compensation, the actuator is unstable when placed on a structure. Relative position feedback is used for actuator stabilization. This method of compensation couples the actuator to the mast in a feedback configuration. Three compensator designs are prop...

Torque ripple reduction of brushless DC motor based on adaptive input-output feedback linearization.

Science.gov (United States)

Shirvani Boroujeni, M; Markadeh, G R Arab; Soltani, J

2017-09-01

Torque ripple reduction of Brushless DC Motors (BLDCs) is an interesting subject in variable speed AC drives. In this paper at first, a mathematical expression for torque ripple harmonics is obtained. Then for a non-ideal BLDC motor with known harmonic contents of back-EMF, calculation of desired reference current amplitudes, which are required to eliminate some selected harmonics of torque ripple, are reviewed. In order to inject the reference harmonic currents to the motor windings, an Adaptive Input-Output Feedback Linearization (AIOFBL) control is proposed, which generates the reference voltages for three phases voltage source inverter in stationary reference frame. Experimental results are presented to show the capability and validity of the proposed control method and are compared with the vector control in Multi-Reference Frame (MRF) and Pseudo-Vector Control (P-VC) method results. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Exhaustive search of linear information encoding protein-peptide recognition.

Science.gov (United States)

Kelil, Abdellali; Dubreuil, Benjamin; Levy, Emmanuel D; Michnick, Stephen W

2017-04-01

High-throughput in vitro methods have been extensively applied to identify linear information that encodes peptide recognition. However, these methods are limited in number of peptides, sequence variation, and length of peptides that can be explored, and often produce solutions that are not found in the cell. Despite the large number of methods developed to attempt addressing these issues, the exhaustive search of linear information encoding protein-peptide recognition has been so far physically unfeasible. Here, we describe a strategy, called DALEL, for the exhaustive search of linear sequence information encoded in proteins that bind to a common partner. We applied DALEL to explore binding specificity of SH3 domains in the budding yeast Saccharomyces cerevisiae. Using only the polypeptide sequences of SH3 domain binding proteins, we succeeded in identifying the majority of known SH3 binding sites previously discovered either in vitro or in vivo. Moreover, we discovered a number of sites with both non-canonical sequences and distinct properties that may serve ancillary roles in peptide recognition. We compared DALEL to a variety of state-of-the-art algorithms in the blind identification of known binding sites of the human Grb2 SH3 domain. We also benchmarked DALEL on curated biological motifs derived from the ELM database to evaluate the effect of increasing/decreasing the enrichment of the motifs. Our strategy can be applied in conjunction with experimental data of proteins interacting with a common partner to identify binding sites among them. Yet, our strategy can also be applied to any group of proteins of interest to identify enriched linear motifs or to exhaustively explore the space of linear information encoded in a polypeptide sequence. Finally, we have developed a webserver located at http://michnick.bcm.umontreal.ca/dalel, offering user-friendly interface and providing different scenarios utilizing DALEL.

Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases.

Science.gov (United States)

Brady, Scott T; Morfini, Gerardo A

2017-09-01

Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases (AONDs) typically exhibit a "dying back" pattern of degeneration, which is characterized by early deficits in synaptic function and neuritic pathology long before neuronal cell death. Consistent with this observation, multiple unrelated AONDs including Alzheimer's disease, Parkinson's disease, Huntington's disease, and several motor neuron diseases feature early alterations in kinase-based signaling pathways associated with deficits in axonal transport (AT), a complex cellular process involving multiple intracellular trafficking events powered by microtubule-based motor proteins. These pathogenic events have important therapeutic implications, suggesting that a focus on preservation of neuronal connections may be more effective to treat AONDs than addressing neuronal cell death. While the molecular mechanisms underlying AT abnormalities in AONDs are still being analyzed, evidence has accumulated linking those to a well-established pathological hallmark of multiple AONDs: altered patterns of neuronal protein phosphorylation. Here, we present a short overview on the biochemical heterogeneity of major motor proteins for AT, their regulation by protein kinases, and evidence revealing cell type-specific AT specializations. When considered together, these findings may help explain how independent pathogenic pathways can affect AT differentially in the context of each AOND. Copyright © 2017 Elsevier Inc. All rights reserved.

Control de velocidad del motor de indución empleando linealización por realimentación de estados Speed control of induction motor using state feedback linearization

Directory of Open Access Journals (Sweden)

Eduardo Giraldo Suárez

2009-01-01

Full Text Available Este documento presenta la aplicación de la técnica de control no lineal clásica llamada linealización por realimentación de variables de estado. Se hace una aplicación en el motor de inducción, la variable a controlar es la velocidad del eje del motor, el sistema emplea el esquema de control vectorial para máquinas de corriente alterna desarrollado en las últimas décadas; este método es análogo a la técnica de control del motor de corriente directa. El modelo del motor de inducción se describe en el sistema de coordenadas de campo orientado del flujo de rotor y se muestra una introducción al producto y la derivada de Lie, empleados en el diseño del controlador no lineal.This articles shows the application of a classic non-linear control technique called "linearization by feedback of status variables." An application on the induction engine is made. Variable to be controlled is speed of the engine shaft. The system employs a vectorial control scheme for AC engines developed during the last decades. This is a method analogous to the DC engine control technique. Induction engine model is described in the guided field coordinate system of rotor flow. Introduction to the product and Lie derivative used for designing the non-linear controller are shown.

Shuffle motor: a high force, high precision linear electrostatic stepper motor

NARCIS (Netherlands)

Tas, Niels Roelof; Wissink, Jeroen; Sander, A.F.M.; Sander, Louis; Lammerink, Theodorus S.J.; Elwenspoek, Michael Curt

1997-01-01

The shuffle motor is a electrostatic stepper motor that employs a mechanical transformation to obtain high forces and small steps. A model has been made to calculate the driving voltage, step size and maximum load to pull as well as the optimal geometry. Tests results are an effective step size of

Pole-shape optimization of permanent-magnet linear synchronous motor for reduction of thrust ripple

Energy Technology Data Exchange (ETDEWEB)

Tavana, Nariman Roshandel, E-mail: nroshandel@ee.iust.ac.i [Department of Electrical Engineering, Iran University of Science and Technology, Narmak, Tehran 16846-13114 (Iran, Islamic Republic of); Shoulaie, Abbas, E-mail: shoulaie@iust.ac.i [Department of Electrical Engineering, Iran University of Science and Technology, Narmak, Tehran 16846-13114 (Iran, Islamic Republic of)

2011-01-15

In this paper, we have used magnet arc shaping technique in order to improve the performance of permanent-magnet linear synchronous motor (PMLSM). At first, a detailed analytical modeling based on Maxwell equations is presented for the analysis and design of PMLSM with the arc-shaped magnetic poles (ASMPs). Then the accuracy of presented method is verified by finite-element method. Very close agreement between the analytical and finite-element results shows the effectiveness of the proposed method. Finally, a magnet shape design is carried out based on the analytical method to enhance the motor developed thrust. Pertinent evaluations on the optimal design performance demonstrate that shape optimization leads to a design with extra low thrust ripple.

Pole-shape optimization of permanent-magnet linear synchronous motor for reduction of thrust ripple

International Nuclear Information System (INIS)

Tavana, Nariman Roshandel; Shoulaie, Abbas

2011-01-01

In this paper, we have used magnet arc shaping technique in order to improve the performance of permanent-magnet linear synchronous motor (PMLSM). At first, a detailed analytical modeling based on Maxwell equations is presented for the analysis and design of PMLSM with the arc-shaped magnetic poles (ASMPs). Then the accuracy of presented method is verified by finite-element method. Very close agreement between the analytical and finite-element results shows the effectiveness of the proposed method. Finally, a magnet shape design is carried out based on the analytical method to enhance the motor developed thrust. Pertinent evaluations on the optimal design performance demonstrate that shape optimization leads to a design with extra low thrust ripple.

Simulation of magnetic induction distribution in a coaxial linear motor with axial and radial direction of permanent magnets magnetization

Directory of Open Access Journals (Sweden)

G.M. Golenkov

2014-03-01

Full Text Available The paper presents results of computer simulation and experimental study of magnetic induction distribution in a coaxial linear motor air gap throughout the length of the runner active part at different heights of the air gap between the runner and the inductor magnetic core for motors with axial and radial direction of the permanent magnets magnetization.

Optimization and Analysis of a U-Shaped Linear Piezoelectric Ultrasonic Motor Using Longitudinal Transducers.

Science.gov (United States)

Yu, Hongpeng; Quan, Qiquan; Tian, Xinqi; Li, He

2018-03-07

A novel U-shaped piezoelectric ultrasonic motor that mainly focused on miniaturization and high power density was proposed, fabricated, and tested in this work. The longitudinal vibrations of the transducers were excited to form the elliptical movements on the driving feet. Finite element method (FEM) was used for design and analysis. The resonance frequencies of the selected vibration modes were tuned to be very close to each other with modal analysis and the movement trajectories of the driving feet were gained with transient simulation. The vibration modes and the mechanical output abilities were tested to evaluate the proposed motor further by a prototype. The maximum output speed was tested to be 416 mm/s, the maximum thrust force was 21 N, and the maximum output power was 5.453 W under frequency of 29.52 kHz and voltage of 100 V rms . The maximum output power density of the prototype reached 7.59 W/kg, which was even greater than a previous similar motor under the exciting voltage of 200 V rms . The proposed motor showed great potential for linear driving of large thrust force and high power density.

Inhibition linearizes firing rate responses in human motor units: implications for the role of persistent inward currents.

Science.gov (United States)

Revill, Ann L; Fuglevand, Andrew J

2017-01-01

Motor neurons are the output neurons of the central nervous system and are responsible for controlling muscle contraction. When initially activated during voluntary contraction, firing rates of motor neurons increase steeply but then level out at modest rates. Activation of an intrinsic source of excitatory current at recruitment onset may underlie the initial steep increase in firing rate in motor neurons. We attempted to disable this intrinsic excitatory current by artificially activating an inhibitory reflex. When motor neuron activity was recorded while the inhibitory reflex was engaged, firing rates no longer increased steeply, suggesting that the intrinsic excitatory current was probably responsible for the initial sharp rise in motor neuron firing rate. During graded isometric contractions, motor unit (MU) firing rates increase steeply upon recruitment but then level off at modest rates even though muscle force continues to increase. The mechanisms underlying such firing behaviour are not known although activation of persistent inward currents (PICs) might be involved. PICs are intrinsic, voltage-dependent currents that activate strongly when motor neurons (MNs) are first recruited. Such activation might cause a sharp escalation in depolarizing current and underlie the steep initial rise in MU firing rate. Because PICs can be disabled with synaptic inhibition, we hypothesized that artificial activation of an inhibitory pathway might curb this initial steep rise in firing rate. To test this, human subjects performed slow triangular ramp contractions of the ankle dorsiflexors in the absence and presence of tonic synaptic inhibition delivered to tibialis anterior (TA) MNs by sural nerve stimulation. Firing rate profiles (expressed as a function of contraction force) of TA MUs recorded during these tasks were compared for control and stimulation conditions. Under control conditions, during the ascending phase of the triangular contractions, 93% of the firing

Dosage-dependent non-linear effect of L-dopa on human motor cortex plasticity.

Science.gov (United States)

Monte-Silva, Katia; Liebetanz, David; Grundey, Jessica; Paulus, Walter; Nitsche, Michael A

2010-09-15

The neuromodulator dopamine affects learning and memory formation and their likely physiological correlates, long-term depression and potentiation, in animals and humans. It is known from animal experiments that dopamine exerts a dosage-dependent, inverted U-shaped effect on these functions. However, this has not been explored in humans so far. In order to reveal a non-linear dose-dependent effect of dopamine on cortical plasticity in humans, we explored the impact of 25, 100 and 200 mg of L-dopa on transcranial direct current (tDCS)-induced plasticity in twelve healthy human subjects. The primary motor cortex served as a model system, and plasticity was monitored by motor evoked potential amplitudes elicited by transcranial magnetic stimulation. As compared to placebo medication, low and high dosages of L-dopa abolished facilitatory as well as inhibitory plasticity, whereas the medium dosage prolonged inhibitory plasticity, and turned facilitatory plasticity into inhibition. Thus the results show clear non-linear, dosage-dependent effects of dopamine on both facilitatory and inhibitory plasticity, and support the assumption of the importance of a specific dosage of dopamine optimally suited to improve plasticity. This might be important for the therapeutic application of dopaminergic agents, especially for rehabilitative purposes, and explain some opposing results in former studies.

A Low Mass Translation Mechanism for Planetary FTIR Spectrometry using an Ultrasonic Piezo Linear Motor

Science.gov (United States)

Heverly, Matthew; Dougherty, Sean; Toon, Geoffrey; Soto, Alejandro; Blavier, Jean-Francois

2004-01-01

One of the key components of a Fourier Transform Infrared Spectrometer (FTIR) is the linear translation stage used to vary the optical path length between the two arms of the interferometer. This translation mechanism must produce extremely constant velocity motion across its entire range of travel to allow the instrument to attain high signal-to-noise ratio and spectral resolving power. A new spectrometer is being developed at the Jet Propulsion Laboratory under NASA s Planetary Instrument Definition and Development Program (PIDDP). The goal of this project is to build upon existing spaceborne FTIR spectrometer technology to produce a new instrument prototype that has drastically superior spectral resolution and substantially lower mass, making it feasible for planetary exploration. In order to achieve these goals, Alliance Spacesystems, Inc. (ASI) has developed a linear translation mechanism using a novel ultrasonic piezo linear motor in conjunction with a fully kinematic, fault tolerant linear rail system. The piezo motor provides extremely smooth motion, is inherently redundant, and is capable of producing unlimited travel. The kinematic rail uses spherical Vespel(R). rollers and bushings, which eliminates the need for wet lubrication, while providing a fault tolerant platform for smooth linear motion that will not bind under misalignment or structural deformation. This system can produce velocities from 10 - 100 mm/s with less than 1% velocity error over the entire 100-mm length of travel for a total mechanism mass of less than 850 grams. This system has performed over half a million strokes under vacuum without excessive wear or degradation in performance. This paper covers the design, development, and testing of this linear translation mechanism as part of the Planetary Atmosphere Occultation Spectrometer (PAOS) instrument prototype development program.

Ultraprecision XY stage using a hybrid bolt-clamped Langevin-type ultrasonic linear motor for continuous motion.

Science.gov (United States)

Lee, Dong-Jin; Lee, Sun-Kyu

2015-01-01

This paper presents a design and control system for an XY stage driven by an ultrasonic linear motor. In this study, a hybrid bolt-clamped Langevin-type ultrasonic linear motor was manufactured and then operated at the resonance frequency of the third longitudinal and the sixth lateral modes. These two modes were matched through the preload adjustment and precisely tuned by the frequency matching method based on the impedance matching method with consideration of the different moving weights. The XY stage was evaluated in terms of position and circular motion. To achieve both fine and stable motion, the controller consisted of a nominal characteristics trajectory following (NCTF) control for continuous motion, dead zone compensation, and a switching controller based on the different NCTFs for the macro- and micro-dynamics regimes. The experimental results showed that the developed stage enables positioning and continuous motion with nanometer-level accuracy.

Position Control of Linear Synchronous Motor Drives with Exploitation of Forced Dynamics Control Principles

Directory of Open Access Journals (Sweden)

Jan Vittek

2004-01-01

Full Text Available Closed-loop position control of mechanisms directly driven by linear synchronous motors with permanent magnets is presented. The control strategy is based on forced dynamic control, which is a form of feedback linearisation, yielding a non-liner multivariable control law to obtain a prescribed linear speed dynamics together with the vector control condition of mutal orthogonality between the stator current and magnetic flux vectors (assuming perfect estimates of the plant parameters. Outer position control loop is closed via simple feedback with proportional gain. Simulations of the design control sysstem, including the drive with power electronic switching, predict the intended drive performance.

Air-gap field, induced voltage and thrust in the short-stator linear induction motor

Energy Technology Data Exchange (ETDEWEB)

Deleroi, W

1980-07-15

The description of the magnetic field in the air-gap of a short-primary linear induction motor, and the subsequent calculation of the thrust developed and the voltages induced in the stator bars can be made by using balancing waves. These balancing waves are generated at any point where the field wave that would exist in a machine of infinite length is disturbed. In the linear motor these disturbances occur at the ends of the stator iron and at discontinuities in the distribution of the stator winding, which exist in machines having stepped windings. From the points where they are generated, free balancing waves travel in two directions and determine the performance of these machines to a large extent. The voltage they induce in a stator bar can be determined from the core flux and mapped on a phasor diagram. The resulting voltage phasor follows a logarithmic spiral. The resulting voltages induced in the three phase windings form a strongly asymmetrical system which can be split-up into positive-, negative- and zerosequence components depending on the slip. The tangential forces may be calculated as the product of the magnetic flux density in the air-gap and the linear current density in either the stator or the reaction rail. As the 'magnetic tail' outside the machine also gives rise to forces in the direction of motion, both methods yield quite different force distributions, though for the resulting force the same value is found.

An electrostatic 3-phase linear stepper motor fabricated by vertical trench isolation technology

Science.gov (United States)

Sarajlic, Edin; Yamahata, Christophe; Cordero, Mauricio; Fujita, Hiroyuki

2009-07-01

We present the design, microfabrication and characterization of an electrostatic 3-phase linear stepper micromotor constructed with vertical trench isolation technology. This suitable technology was used to create a monolithic stepper motor with high-aspect-ratio poles and an integrated 3-phase electrical network in the bulk of a standard single-crystal silicon wafer. The shuttle of the stepper motor is suspended by a flexure to avoid any mechanical contact during operation, enhancing the precision, repeatability and reliability of the stepping motion. The prototype is capable of a maximum travel of +/-26 µm (52 µm) at an actuation voltage of 30 V and a step size of 1.4 µm during a half-stepping sequence. This work was presented in part at the 19th MicroMechanics Europe Workshop (MME), 28-30 September 2008, Aachen, Germany.

Ubiquitin–Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice

Science.gov (United States)

Liu, Yun; Li, Hongqiao; Sugiura, Yoshie; Han, Weiping; Gallardo, Gilbert; Khvotchev, Mikhail; Zhang, Yinan; Kavalali, Ege T.; Südhof, Thomas C.

2015-01-01

Protein aggregates containing ubiquitin (Ub) are commonly observed in neurodegenerative disorders, implicating the involvement of the ubiquitin proteasome system (UPS) in their pathogenesis. Here, we aimed to generate a mouse model for monitoring UPS function using a green fluorescent protein (GFP)-based substrate that carries a “noncleavable” N-terminal ubiquitin moiety (UbG76V). We engineered transgenic mice expressing a fusion protein, consisting of the following: (1) UbG76V, GFP, and a synaptic vesicle protein synaptobrevin-2 (UbG76V-GFP-Syb2); (2) GFP-Syb2; or (3) UbG76V-GFP-Syntaxin1, all under the control of a neuron-specific Thy-1 promoter. As expected, UbG76V-GFP-Syb2, GFP-Syb2, and UbG76V-GFP-Sytaxin1 were highly expressed in neurons, such as motoneurons and motor nerve terminals of the neuromuscular junction (NMJ). Surprisingly, UbG76V-GFP-Syb2 mice developed progressive adult-onset degeneration of motor nerve terminals, whereas GFP-Syb2 and UbG76V-GFP-Syntaxin1 mice were normal. The degeneration of nerve terminals in UbG76V-GFP-Syb2 mice was preceded by a progressive impairment of synaptic transmission at the NMJs. Biochemical analyses demonstrated that UbG76V-GFP-Syb2 interacted with SNAP-25 and Syntaxin1, the SNARE partners of synaptobrevin. Ultrastructural analyses revealed a marked reduction in synaptic vesicle density, accompanying an accumulation of tubulovesicular structures at presynaptic nerve terminals. These morphological defects were largely restricted to motor nerve terminals, as the ultrastructure of motoneuron somata appeared to be normal at the stages when synaptic nerve terminals degenerated. Furthermore, synaptic vesicle endocytosis and membrane trafficking were impaired in UbG76V-GFP-Syb2 mice. These findings indicate that UbG76V-GFP-Syb2 may compete with endogenous synaptobrevin, acting as a gain-of-function mutation that impedes SNARE function, resulting in the depletion of synaptic vesicles and degeneration of the nerve

Comparison of Thrust Characteristics in Pencil Sized Cylinder-type Linear Motors with Different Magnet Arrays

OpenAIRE

Nakaiwa, K; Yamada, A; Tashiro, K; Wakiwaka, H

2009-01-01

From a strong demand on the miniaturization of a chip mounter or a semiconductor device, the thrust improvement considering the magnets arrangement is studied. We accept a core stator with a Halbach type magnet array for a current linear motor. The thrust characteristics are compared with two kinds of mover, a NS magnet array and a Halbach magnet array.

LINEARIZATION OF THE BRADFORD PROTEIN ASSAY TO APPLICATION IN COW MILK PROTEINS QUANTIFICATION BY UV-Vis SPECTROPHOTOMETRY METHOD

Directory of Open Access Journals (Sweden)

Alessa Siqueira de Oliveira dos Santos

2015-01-01

Full Text Available Reliable methods for determination and quantification of total protein in food are essential information to ensure quality and safety of food trade. The objective of this study was to evaluate the linearity of calibration curves obtained from different proteins (blood serum albumin-BSA, α-LA, β-LG, caseins (CN: αs, β and κ-CAS with the reagent of Bradford. Comercial UHT skimmed bovine milk was analyzed for the determination of total protein using the Bradford method by reading at 595 nm. The determination of the concentrations of total milk protein was achieved by linear regression. The Bradford method showed a high sensitivity for the determination of total proteins in bovine milk dilution 1:25 to values closer to those obtained by the Kjeldahl method. The results showed that the calibration curve of standard proteins β-CN and BSA obtained better linearity with less variation in the absorbance measurements for the determination of total protein of milk.

Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins.

Science.gov (United States)

Goshima, Gohta; Nédélec, François; Vale, Ronald D

2005-10-24

During the formation of the metaphase spindle in animal somatic cells, kinetochore microtubule bundles (K fibers) are often disconnected from centrosomes, because they are released from centrosomes or directly generated from chromosomes. To create the tightly focused, diamond-shaped appearance of the bipolar spindle, K fibers need to be interconnected with centrosomal microtubules (C-MTs) by minus end-directed motor proteins. Here, we have characterized the roles of two minus end-directed motors, dynein and Ncd, in such processes in Drosophila S2 cells using RNA interference and high resolution microscopy. Even though these two motors have overlapping functions, we show that Ncd is primarily responsible for focusing K fibers, whereas dynein has a dominant function in transporting K fibers to the centrosomes. We also report a novel localization of Ncd to the growing tips of C-MTs, which we show is mediated by the plus end-tracking protein, EB1. Computer modeling of the K fiber focusing process suggests that the plus end localization of Ncd could facilitate the capture and transport of K fibers along C-MTs. From these results and simulations, we propose a model on how two minus end-directed motors cooperate to ensure spindle pole coalescence during mitosis.

Imaging Flow Cytometry Analysis to Identify Differences of Survival Motor Neuron Protein Expression in Patients With Spinal Muscular Atrophy.

Science.gov (United States)

Arakawa, Reiko; Arakawa, Masayuki; Kaneko, Kaori; Otsuki, Noriko; Aoki, Ryoko; Saito, Kayoko

2016-08-01

Spinal muscular atrophy is a neurodegenerative disorder caused by the deficient expression of survival motor neuron protein in motor neurons. A major goal of disease-modifying therapy is to increase survival motor neuron expression. Changes in survival motor neuron protein expression can be monitored via peripheral blood cells in patients; therefore we tested the sensitivity and utility of imaging flow cytometry for this purpose. After the immortalization of peripheral blood lymphocytes from a human healthy control subject and two patients with spinal muscular atrophy type 1 with two and three copies of SMN2 gene, respectively, we used imaging flow cytometry analysis to identify significant differences in survival motor neuron expression. A bright detail intensity analysis was used to investigate differences in the cellular localization of survival motor neuron protein. Survival motor neuron expression was significantly decreased in cells derived from patients with spinal muscular atrophy relative to those derived from a healthy control subject. Moreover, survival motor neuron expression correlated with the clinical severity of spinal muscular atrophy according to SMN2 copy number. The cellular accumulation of survival motor neuron protein was also significantly decreased in cells derived from patients with spinal muscular atrophy relative to those derived from a healthy control subject. The benefits of imaging flow cytometry for peripheral blood analysis include its capacities for analyzing heterogeneous cell populations; visualizing cell morphology; and evaluating the accumulation, localization, and expression of a target protein. Imaging flow cytometry analysis should be implemented in future studies to optimize its application as a tool for spinal muscular atrophy clinical trials. Copyright © 2016 Elsevier Inc. All rights reserved.

MODELING OF OPERATION OF COAXIAL-LINEAR MOTORS WITH AXIAL AND RADIAL DIRECTIONS OF MAGNETIZATION OF PERMANENT MAGNETS IN DYNAMIC MODE

Directory of Open Access Journals (Sweden)

G.M. Golenkov

2014-12-01

Full Text Available Theoretical and experimental investigations of the amplitude, phase and inertia-power frequency characteristics of two types of coaxial-linear electric motors of back-and-forth motion with permanent magnets, which magnetization vector is directed axially and radially relative to the axis of the runner are carried out. The comparative analysis of characteristics of these motors is presented.

Design of a Control System for a Maglev Planar Motor Based on Two-Dimension Linear Interpolation

Directory of Open Access Journals (Sweden)

Feng Xing

2017-08-01

Full Text Available In order to realize the high speed and high-precision control of a maglev planar motor, a high-precision electromagnetic model is needed in the first place, which can also contribute to meeting the real-time running requirements. Traditionally, the electromagnetic model is based on analytical calculations. However, this neglects the model simplification and the manufacturing errors, which may bring certain errors to the model. Aiming to handle this inaccuracy, this paper proposes a novel design method for a maglev planar motor control system based on two-dimensional linear interpolation. First, the magnetic field is divided into several regions according to the symmetry of the Halbach magnetic array, and the uniform grid method is adopted to partition one of these regions. Second, targeting this region, it is possible to sample the electromagnetic forces and torques on each node of the grid and obtain the complete electromagnetic model in this region through the two-dimensional linear interpolation method. Third, the whole electromagnetic model of the maglev planar motor can be derived according to the symmetry of the magnetic field. Finally, the decoupling method and controller are designed according to this electromagnetic model, and thereafter, the control model can be established. The designed control system is demonstrated through simulations and experiments to feature better accuracy and meet the requirements of real-time control.

Linear pulse motor type control element drive mechanism for the integral reactor

International Nuclear Information System (INIS)

Yu, J. Y.; Choi, S.; Kim, J. H.; Huh, H.; Park, K. B.

2007-01-01

The integral reactor SMART currently under development at Korea Atomic Energy Research Institute is designed with soluble boron free operation and use of nuclear heating for reactor startup. These design features require the Control Element Drive Mechanism (CEDM) for SMART to have fine-step movement capability as well as high reliability for the fine reactivity control. In this paper, design characteristics of a new concept CEDM driven by the Linear Pulse Motor (LPM) which meets the design requirements of the integral reactor SMART are introduced. The primary dimensions of the linear pulse motor are determined by the electro-magnetic analysis and the results are also presented. In parallel with the electro-magnetic analysis, the conceptual design of the CEDM is visualized and checked for interferences among parts by assembling three dimensional (3D) models on the computer. Prototype of LPM with double air-gaps for the CEDM sub-assemblies to lift 100 kg is designed, analysed, manufactured and tested to confirm the validity of the CEDM design concept. A converter and a test facility are manufactured to verify the dynamic performance of the LPM. The mover of the LPM is welded with ferromagnetic material and non-ferromagnetic material to get the magnetic flux path between inner stator and outer stator. The thrust forces of LPM predicted by analytic model have shown good agreement with experimental results from the prototype LPM. It is found that the LPM type CEDM has high force density and simple drive mechanism to reduce volume and satisfy the reactor operating circumstances with high pressure and temperature

Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein

International Nuclear Information System (INIS)

Delorme, Caroline; Joshi, Monika; Allingham, John S.

2012-01-01

Highlights: ► The Candida albicans Kar3 motor domain structure was solved as a maltose-binding protein fusion. ► The electrostatic surface and part of the ATPase pocket of the motor domain differs markedly from other kinesins. ► The MBP–Kar3 interface highlights a new site for intramolecular or intermolecular interactions. -- Abstract: In the human fungal pathogen Candida albicans, the Kinesin-14 motor protein Kar3 (CaKar3) is critical for normal mitotic division, nuclear fusion during mating, and morphogenic transition from the commensal yeast form to the virulent hyphal form. As a first step towards detailed characterization of this motor of potential medical significance, we have crystallized and determined the X-ray structure of the motor domain of CaKar3 as a maltose-binding protein (MBP) fusion. The structure shows strong conservation of overall motor domain topology to other Kar3 kinesins, but with some prominent differences in one of the motifs that compose the nucleotide-binding pocket and the surface charge distribution. The MBP and Kar3 modules are arranged such that MBP interacts with the Kar3 motor domain core at the same site where the neck linker of conventional kinesins docks during the “ATP state” of the mechanochemical cycle. This site differs from the Kar3 neck–core interface in the recent structure of the ScKar3Vik1 heterodimer. The position of MBP is also completely distinct from the Vik1 subunit in this complex. This may suggest that the site of MBP interaction on the CaKar3 motor domain provides an interface for the neck, or perhaps a partner subunit, at an intermediate state of its motile cycle that has not yet been observed for Kinesin-14 motors.

Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein

Energy Technology Data Exchange (ETDEWEB)

Delorme, Caroline; Joshi, Monika [Department of Biomedical and Molecular Sciences, Queen' s University, Kingston, ON, Canada K7L 3N6 (Canada); Allingham, John S., E-mail: allinghj@queensu.ca [Department of Biomedical and Molecular Sciences, Queen' s University, Kingston, ON, Canada K7L 3N6 (Canada)

2012-11-30

Highlights: Black-Right-Pointing-Pointer The Candida albicans Kar3 motor domain structure was solved as a maltose-binding protein fusion. Black-Right-Pointing-Pointer The electrostatic surface and part of the ATPase pocket of the motor domain differs markedly from other kinesins. Black-Right-Pointing-Pointer The MBP-Kar3 interface highlights a new site for intramolecular or intermolecular interactions. -- Abstract: In the human fungal pathogen Candida albicans, the Kinesin-14 motor protein Kar3 (CaKar3) is critical for normal mitotic division, nuclear fusion during mating, and morphogenic transition from the commensal yeast form to the virulent hyphal form. As a first step towards detailed characterization of this motor of potential medical significance, we have crystallized and determined the X-ray structure of the motor domain of CaKar3 as a maltose-binding protein (MBP) fusion. The structure shows strong conservation of overall motor domain topology to other Kar3 kinesins, but with some prominent differences in one of the motifs that compose the nucleotide-binding pocket and the surface charge distribution. The MBP and Kar3 modules are arranged such that MBP interacts with the Kar3 motor domain core at the same site where the neck linker of conventional kinesins docks during the 'ATP state' of the mechanochemical cycle. This site differs from the Kar3 neck-core interface in the recent structure of the ScKar3Vik1 heterodimer. The position of MBP is also completely distinct from the Vik1 subunit in this complex. This may suggest that the site of MBP interaction on the CaKar3 motor domain provides an interface for the neck, or perhaps a partner subunit, at an intermediate state of its motile cycle that has not yet been observed for Kinesin-14 motors.

Population Decoding of Motor Cortical Activity using a Generalized Linear Model with Hidden States

Science.gov (United States)

Lawhern, Vernon; Wu, Wei; Hatsopoulos, Nicholas G.; Paninski, Liam

2010-01-01

Generalized linear models (GLMs) have been developed for modeling and decoding population neuronal spiking activity in the motor cortex. These models provide reasonable characterizations between neural activity and motor behavior. However, they lack a description of movement-related terms which are not observed directly in these experiments, such as muscular activation, the subject's level of attention, and other internal or external states. Here we propose to include a multi-dimensional hidden state to address these states in a GLM framework where the spike count at each time is described as a function of the hand state (position, velocity, and acceleration), truncated spike history, and the hidden state. The model can be identified by an Expectation-Maximization algorithm. We tested this new method in two datasets where spikes were simultaneously recorded using a multi-electrode array in the primary motor cortex of two monkeys. It was found that this method significantly improves the model-fitting over the classical GLM, for hidden dimensions varying from 1 to 4. This method also provides more accurate decoding of hand state (lowering the Mean Square Error by up to 29% in some cases), while retaining real-time computational efficiency. These improvements on representation and decoding over the classical GLM model suggest that this new approach could contribute as a useful tool to motor cortical decoding and prosthetic applications. PMID:20359500

A novel L-shaped linear ultrasonic motor operating in a single resonance mode

Science.gov (United States)

Zhang, Bailiang; Yao, Zhiyuan; Liu, Zhen; Li, Xiaoniu

2018-01-01

In this study, a large thrust linear ultrasonic motor using an L-shaped stator is described. The stator is constructed by two mutually perpendicular rectangular plate vibrators, one of which is mounted in parallel with the slider to make the motor structure to be more compact. The symmetric and antisymmetric modes of the stator based on the first order bending vibration of two vibrators are adopted, in which each resonance mode is assigned to drive the slider in one direction. The placement of piezoelectric ceramics in a stator could be determined by finite element analysis, and the influence of slots in the head block on the vibration amplitudes of driving foot was studied as well. Three types of prototypes (non-slotted, dual-slot, and single-slot) were fabricated and experimentally investigated. Experimental results demonstrated that the prototype with one slot exhibited the best mechanical output performance. The maximum loads under the excitation of symmetric mode and antisymmetric mode were 65 and 90 N, respectively.

CEDM Controller for a Linear Pulse Motor by using Pulse Width Modulation Method in Integral Reactor

International Nuclear Information System (INIS)

Lee, Joon-Koo; Keum, Jong-Yong; Park, Heui-Youn

2007-01-01

Integral Reactor SMART is under development at KAERI. The design characteristics of SMART are radically different from those employed in currently operating loop type PWR in Korea. The reliability and accuracy of Control Rod Drive Mechanism are very important to the reactor safety and the design of the Plant Protection System. The SMART CEDM designed for fine-step movement consists of a linear pulse motor, reed switch type sensor with top and bottom limit switches which also act as Control Element Assembly(CEA) Position indicator, The linear pulse motor is a four phase synchronous DC electric machine with inner stator and output stator in coolant medium inside a strong housing. The objective of this paper is to introduce and to explain the CEDM controller CEDM Controller is being developed with a new design concept and digital technology to reduce the Operating Error and improve the systems' reliability and availability. And Switched Mode Power Supply is also being developed with digital hardware technology. This paper involves the test details and result

Development of Propulsion Inverter Control System for High-Speed Maglev based on Long Stator Linear Synchronous Motor

Directory of Open Access Journals (Sweden)

Jeong-Min Jo

2017-02-01

Full Text Available In the case of a long-stator linear drive, unlike rotative drives for which speed or position sensors are a single unit attached to the shaft, these sensors extend along the guideway. The position signals transmitted from a maglev vehicle cannot meet the need of the real-time propulsion control in the on-ground inverter power substations. In this paper the design of the propulsion inverter control system with a position estimator for driving a long-stator synchronous motor in a high-speed maglev train is proposed. The experiments have been carried out at the 150 m long guideway at the O-song test track. To investigate the performance of the position estimator, the propulsion control system with, and without, the position estimator are compared. The result confirms that the proposed strategy can meet the dynamic property needs of the propulsion inverter control system for driving long-stator linear synchronous motors.

Intelligent measurement and compensation of linear motor force ripple: a projection-based learning approach in the presence of noise

Science.gov (United States)

Liu, Yang; Song, Fazhi; Yang, Xiaofeng; Dong, Yue; Tan, Jiubin

2018-06-01

Due to their structural simplicity, linear motors are increasingly receiving attention for use in high velocity and high precision applications. The force ripple, as a space-periodic disturbance, however, would deteriorate the achievable dynamic performance. Conventional force ripple measurement approaches are time-consuming and have high requirements on the experimental conditions. In this paper, a novel learning identification algorithm is proposed for force ripple intelligent measurement and compensation. Existing identification schemes always use all the error signals to update the parameters in the force ripple. However, the error induced by noise is non-effective for force ripple identification, and even deteriorates the identification process. In this paper only the most pertinent information in the error signal is utilized for force ripple identification. Firstly, the effective error signals caused by the reference trajectory and the force ripple are extracted by projecting the overall error signals onto a subspace spanned by the physical model of the linear motor as well as the sinusoidal model of the force ripple. The time delay in the linear motor is compensated in the basis functions. Then, a data-driven approach is proposed to design the learning gain. It balances the trade-off between convergence speed and robustness against noise. Simulation and experimental results validate the proposed method and confirm its effectiveness and superiority.

Protein Synthesis Inhibition Blocks Consolidation of an Acrobatic Motor Skill

Science.gov (United States)

Kaelin-Lang, Alain; Dichgans, Johannes; Schulz, Jorg B.; Luft, Andreas R.; Buitrago, Manuel M.

2004-01-01

To investigate whether motor skill learning depends on de novo protein synthesis, adult rats were trained in an acrobatic locomotor task (accelerating rotarod) for 7 d. Animals were systemically injected with cycloheximide (CHX, 0.5 mg/kg, i.p.) 1 h before sessions 1 and 2 or sessions 2 and 3. Control rats received vehicle injections before…

Development of linear pulse motor type control element drive mechanism for smart

International Nuclear Information System (INIS)

Je-Yong, Yu; Jong-in, Kim; Ji-ho, Kim; Hyung, Huh; Moon-Hee, Chang

2001-01-01

The system-integrated modular advanced reactor (SMART) currently under development at the Korea Atomic Energy Research Institute is being designed with soluble boron free operation and the use of nuclear heating for reactor start-up. These design features require a Control Element Drive Mechanism(CEDM) for SMART to have fine-step movement capability as well as high reliability for fine reactivity control. In this paper, the design characteristics of a new concept CEDM driven by a Linear Pulse Motor (LPM) which meets the design requirements of the integral reactor SMART are introduced. The primary dimensions of the linear pulse motor are determined by electro-magnetic analysis and the results are also presented. In parallel with the electro-magnetic analysis, the conceptual design of the CEDM is visualized and checked for interferences among parts by assembling three dimensional (3D) models on computer. A prototype of the LPM with double air-gaps for the CEDM sub-assemblies to lift 100 kg is designed, analysed, manufactured and tested to confirm the validity of the CEDM design concept. A converter and test facility are manufactured to verify the dynamic performance of the LPM. The mover of the LPM is welded with ferromagnetic material and non-ferromagnetic material to get the magnetic flux path between the inner stator and outer stator. The thrust forces of LPM predicted by the analytic model have shown good agreement with experimental results from the prototype LPM. It is found that the LPM type CEDM has high force density and a simple drive mechanism to reduce volume and satisfy reactor operating circumstances with high pressure and temperature. (authors)

Motor coordination defects in mice deficient for the Sam68 RNA-binding protein.

Science.gov (United States)

Lukong, Kiven E; Richard, Stéphane

2008-06-03

The role of RNA-binding proteins in the central nervous system and more specifically their role in motor coordination and learning are poorly understood. We previously reported that ablation of RNA-binding protein Sam68 in mice results in male sterility and delayed mammary gland development and protection against osteoporosis in females. Sam68 however is highly expressed in most regions of the brain especially the cerebellum and thus we investigated the cerebellar-related manifestations in Sam68-null mice. We analyzed the mice for motor function, sensory function, and learning and memory abilities. Herein, we report that Sam68-null mice have motor coordination defects as assessed by beam walking and rotorod performance. Forty-week-old Sam68-null mice (n=12) were compared to their wild-type littermates (n=12). The Sam68-null mice exhibited more hindpaw faults in beam walking tests and fell from the rotating drum at lower speeds and prematurely compared to the wild-type controls. The Sam68-null mice were, however, normal for forelimb strength, tail-hang reflex, balance test, grid walking, the Morris water task, recognition memory, visual discrimination, auditory stimulation and conditional taste aversion. Our findings support a role for Sam68 in the central nervous system in the regulation of motor coordination.

Bio-inspired piezoelectric linear motor driven by a single-phase harmonic wave with an asymmetric stator.

Science.gov (United States)

Pan, Qiaosheng; Miao, Enming; Wu, Bingxuan; Chen, Weikang; Lei, Xiujun; He, Liangguo

2017-07-01

A novel, bio-inspired, single-phase driven piezoelectric linear motor (PLM) using an asymmetric stator was designed, fabricated, and tested to avoid mode degeneracy and to simplify the drive mechanism of a piezoelectric motor. A piezoelectric transducer composed of two piezoelectric stacks and a displacement amplifier was used as the driving element of the PLM. Two simple and specially designed claws performed elliptical motion. A numerical simulation was performed to design the stator and determine the feasibility of the design mechanism of the PLM. Moreover, an experimental setup was built to validate the working principles, as well as to evaluate the performance, of the PLM. The prototype motor outputs a no-load speed of 233.7 mm/s at a voltage of 180 V p-p and a maximum thrust force of 2.3 N under a preload of 10 N. This study verified the feasibility of the proposed design and provided a method to simplify the driving harmonic signal and structure of PLMs.

A Linear Electromagnetic Piston Pump

Science.gov (United States)

Hogan, Paul H.

Advancements in mobile hydraulics for human-scale applications have increased demand for a compact hydraulic power supply. Conventional designs couple a rotating electric motor to a hydraulic pump, which increases the package volume and requires several energy conversions. This thesis investigates the use of a free piston as the moving element in a linear motor to eliminate multiple energy conversions and decrease the overall package volume. A coupled model used a quasi-static magnetic equivalent circuit to calculate the motor inductance and the electromagnetic force acting on the piston. The force was an input to a time domain model to evaluate the mechanical and pressure dynamics. The magnetic circuit model was validated with finite element analysis and an experimental prototype linear motor. The coupled model was optimized using a multi-objective genetic algorithm to explore the parameter space and maximize power density and efficiency. An experimental prototype linear pump coupled pistons to an off-the-shelf linear motor to validate the mechanical and pressure dynamics models. The magnetic circuit force calculation agreed within 3% of finite element analysis, and within 8% of experimental data from the unoptimized prototype linear motor. The optimized motor geometry also had good agreement with FEA; at zero piston displacement, the magnetic circuit calculates optimized motor force within 10% of FEA in less than 1/1000 the computational time. This makes it well suited to genetic optimization algorithms. The mechanical model agrees very well with the experimental piston pump position data when tuned for additional unmodeled mechanical friction. Optimized results suggest that an improvement of 400% of the state of the art power density is attainable with as high as 85% net efficiency. This demonstrates that a linear electromagnetic piston pump has potential to serve as a more compact and efficient supply of fluid power for the human scale.

Electromagnetic Performance Calculation of HTS Linear Induction Motor for Rail Systems

Science.gov (United States)

Liu, Bin; Fang, Jin; Cao, Junci; Chen, Jie; Shu, Hang; Sheng, Long

2017-07-01

According to a high temperature superconducting (HTS) linear induction motor (LIM) designed for rail systems, the influence of electromagnetic parameters and mechanical structure parameters on the electromagnetic horizontal thrust, vertical force of HTS LIM and the maximum vertical magnetic field of HTS windings are analyzed. Through the research on the vertical field of HTS windings, the development regularity of the HTS LIM maximum input current with different stator frequency and different thickness value of the secondary conductive plate is obtained. The theoretical results are of great significance to analyze the stability of HTS LIM. Finally, based on theory analysis, HTS LIM test platform was built and the experiment was carried out with load. The experimental results show that the theoretical analysis is correct and reasonable.

Electromagnetic Performance Calculation of HTS Linear Induction Motor for Rail Systems

International Nuclear Information System (INIS)

Liu, Bin; Fang, Jin; Cao, Junci; Chen, Jie; Shu, Hang; Sheng, Long

2017-01-01

According to a high temperature superconducting (HTS) linear induction motor (LIM) designed for rail systems, the influence of electromagnetic parameters and mechanical structure parameters on the electromagnetic horizontal thrust, vertical force of HTS LIM and the maximum vertical magnetic field of HTS windings are analyzed. Through the research on the vertical field of HTS windings, the development regularity of the HTS LIM maximum input current with different stator frequency and different thickness value of the secondary conductive plate is obtained. The theoretical results are of great significance to analyze the stability of HTS LIM. Finally, based on theory analysis, HTS LIM test platform was built and the experiment was carried out with load. The experimental results show that the theoretical analysis is correct and reasonable. (paper)

Population decoding of motor cortical activity using a generalized linear model with hidden states.

Science.gov (United States)

Lawhern, Vernon; Wu, Wei; Hatsopoulos, Nicholas; Paninski, Liam

2010-06-15

Generalized linear models (GLMs) have been developed for modeling and decoding population neuronal spiking activity in the motor cortex. These models provide reasonable characterizations between neural activity and motor behavior. However, they lack a description of movement-related terms which are not observed directly in these experiments, such as muscular activation, the subject's level of attention, and other internal or external states. Here we propose to include a multi-dimensional hidden state to address these states in a GLM framework where the spike count at each time is described as a function of the hand state (position, velocity, and acceleration), truncated spike history, and the hidden state. The model can be identified by an Expectation-Maximization algorithm. We tested this new method in two datasets where spikes were simultaneously recorded using a multi-electrode array in the primary motor cortex of two monkeys. It was found that this method significantly improves the model-fitting over the classical GLM, for hidden dimensions varying from 1 to 4. This method also provides more accurate decoding of hand state (reducing the mean square error by up to 29% in some cases), while retaining real-time computational efficiency. These improvements on representation and decoding over the classical GLM model suggest that this new approach could contribute as a useful tool to motor cortical decoding and prosthetic applications. Copyright (c) 2010 Elsevier B.V. All rights reserved.

The Experimental Study of Rayleigh-Taylor Instability using a Linear Induction Motor Accelerator

Science.gov (United States)

Yamashita, Nicholas; Jacobs, Jeffrey

2009-11-01

The experiments to be presented utilize an incompressible system of two stratified miscible liquids of different densities that are accelerated in order to produce the Rayleigh-Taylor instability. Three liquid combinations are used: isopropyl alcohol with water, a calcium nitrate solution or a lithium polytungstate solution, giving Atwood numbers of 0.11, 0.22 and 0.57, respectively. The acceleration required to drive the instability is produced by two high-speed linear induction motors mounted to an 8 m tall drop tower. The motors are mounted in parallel and have an effective acceleration length of 1.7 m and are each capable of producing 15 kN of thrust. The liquid system is contained within a square acrylic tank with inside dimensions 76 x76x184 mm. The tank is mounted to an aluminum plate, which is driven by the motors to create constant accelerations in the range of 1-20 g's, though the potential exists for higher accelerations. Also attached to the plate are a high-speed camera and an LED backlight to provide continuous video of the instability. In addition, an accelerometer is used to provide acceleration measurements during each experiment. Experimental image sequences will be presented which show the development of a random three-dimensional instability from an unforced initial perturbation. Measurements of the mixing zone width will be compared with traditional growth models.

Protein Synthesis Inhibition in the Peri-Infarct Cortex Slows Motor Recovery in Rats.

OpenAIRE

Schubring-Giese Maximilian; Leemburg Susan; Luft Andreas Rüdiger; Hosp Jonas Aurel

2016-01-01

Neuroplasticity and reorganization of brain motor networks are thought to enable recovery of motor function after ischemic stroke. Especially in the cortex surrounding the ischemic scar (i.e., peri-infarct cortex), evidence for lasting reorganization has been found at the level of neurons and networks. This reorganization depends on expression of specific genes and subsequent protein synthesis. To test the functional relevance of the peri-infarct cortex for recovery we assessed the effect of ...

Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

Science.gov (United States)

Bormuth, Volker; Varga, Vladimir; Howard, Jonathon; Schäffer, Erik

2009-08-14

Friction limits the operation of macroscopic engines and is critical to the performance of micromechanical devices. We report measurements of friction in a biological nanomachine. Using optical tweezers, we characterized the frictional drag force of individual kinesin-8 motor proteins interacting with their microtubule tracks. At low speeds and with no energy source, the frictional drag was related to the diffusion coefficient by the Einstein relation. At higher speeds, the frictional drag force increased nonlinearly, consistent with the motor jumping 8 nanometers between adjacent tubulin dimers along the microtubule, and was asymmetric, reflecting the structural polarity of the microtubule. We argue that these frictional forces arise from breaking bonds between the motor domains and the microtubule, and they limit the speed and efficiency of kinesin.

Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum.

Science.gov (United States)

Alahmadi, Adnan A S; Samson, Rebecca S; Gasston, David; Pardini, Matteo; Friston, Karl J; D'Angelo, Egidio; Toosy, Ahmed T; Wheeler-Kingshott, Claudia A M

2016-06-01

Previous studies have used fMRI to address the relationship between grip force (GF) applied to an object and BOLD response. However, whilst the majority of these studies showed a linear relationship between GF and neural activity in the contralateral M1 and ipsilateral cerebellum, animal studies have suggested the presence of non-linear components in the GF-neural activity relationship. Here, we present a methodology for assessing non-linearities in the BOLD response to different GF levels, within primary motor as well as sensory and cognitive areas and the cerebellum. To be sensitive to complex forms, we designed a feasible grip task with five GF targets using an event-related visually guided paradigm and studied a cohort of 13 healthy volunteers. Polynomial functions of increasing order were fitted to the data. (1) activated motor areas irrespective of GF; (2) positive higher-order responses in and outside M1, involving premotor, sensory and visual areas and cerebellum; (3) negative correlations with GF, predominantly involving the visual domain. Overall, our results suggest that there are physiologically consistent behaviour patterns in cerebral and cerebellar cortices; for example, we observed the presence of a second-order effect in sensorimotor areas, consistent with an optimum metabolic response at intermediate GF levels, while higher-order behaviour was found in associative and cognitive areas. At higher GF levels, sensory-related cortical areas showed reduced activation, interpretable as a redistribution of the neural activity for more demanding tasks. These results have the potential of opening new avenues for investigating pathological mechanisms of neurological diseases.

Non-linear feedback control of the p53 protein-mdm2 inhibitor system using the derivative-free non-linear Kalman filter.

Science.gov (United States)

Rigatos, Gerasimos G

2016-06-01

It is proven that the model of the p53-mdm2 protein synthesis loop is a differentially flat one and using a diffeomorphism (change of state variables) that is proposed by differential flatness theory it is shown that the protein synthesis model can be transformed into the canonical (Brunovsky) form. This enables the design of a feedback control law that maintains the concentration of the p53 protein at the desirable levels. To estimate the non-measurable elements of the state vector describing the p53-mdm2 system dynamics, the derivative-free non-linear Kalman filter is used. Moreover, to compensate for modelling uncertainties and external disturbances that affect the p53-mdm2 system, the derivative-free non-linear Kalman filter is re-designed as a disturbance observer. The derivative-free non-linear Kalman filter consists of the Kalman filter recursion applied on the linearised equivalent of the protein synthesis model together with an inverse transformation based on differential flatness theory that enables to retrieve estimates for the state variables of the initial non-linear model. The proposed non-linear feedback control and perturbations compensation method for the p53-mdm2 system can result in more efficient chemotherapy schemes where the infusion of medication will be better administered.

Linear growth of children on a ketogenic diet: does the protein-to-energy ratio matter?

Science.gov (United States)

Nation, Judy; Humphrey, Maureen; MacKay, Mark; Boneh, Avihu

2014-11-01

Ketogenic diet is a structured effective treatment for children with intractable epilepsy. Several reports have indicated poor linear growth in children on the diet but the mechanism of poor growth has not been elucidated. We aimed to explore whether the protein to energy ratio plays a role in linear growth of children on ketogenic diet. Data regarding growth and nutrition were, retrospectively, collected from the clinical histories of 35 children who were treated with ketogenic diet for at least 6 months between 2002 and 2010. Patients were stratified into groups according to periods of satisfactory or poor linear growth. Poor linear growth was associated with protein or caloric intake of <80% recommended daily intake, and with a protein-to-energy ratio consistently ≤1.4 g protein/100 kcal even when protein and caloric intakes were adequate. We recommend a protein-to-energy ratio of 1.5 g protein/100 kcal be prescribed to prevent growth retardation. © The Author(s) 2013.

Recession in a linear stepper motor based on piezoelectric actuator and electrorheological clampers

International Nuclear Information System (INIS)

Li, Cuihong; Meng, Yonggang; Tian, Yu

2012-01-01

A linear inchworm-type stepper motor based on piezoelectric actuator and comb shape electrorheological (ER) clampers was developed and tested. A recession phenomenon in the movement of the motor was found and was significantly affected by the driving voltage of the piezoelectric actuator and ER fluids. A dynamic model to analyze the mechanism of the recession was established. The force ratio of the viscoelastic clamping force (applied high electric field) to the viscous damping force (zero field) of ER fluids is the critical factor which determines the recession. The ratio is also affected by the extension or contraction rate of the actuator during movement, which is affected by the charging and discharging processes. With a relatively large distance between the clamper electrodes and a small displacement activated by the extension of the piezoelectric actuator, the instantaneous shear rate might not be sufficiently high, preventing ER fluids from attaining a shear-thickened and high-strength state. The ratio of yield strength to the viscous strength of ER fluids during movement should be as large as possible to reduce the recession displacement. (paper)

Automatic Human Movement Assessment With Switching Linear Dynamic System: Motion Segmentation and Motor Performance.

Science.gov (United States)

de Souza Baptista, Roberto; Bo, Antonio P L; Hayashibe, Mitsuhiro

2017-06-01

Performance assessment of human movement is critical in diagnosis and motor-control rehabilitation. Recent developments in portable sensor technology enable clinicians to measure spatiotemporal aspects to aid in the neurological assessment. However, the extraction of quantitative information from such measurements is usually done manually through visual inspection. This paper presents a novel framework for automatic human movement assessment that executes segmentation and motor performance parameter extraction in time-series of measurements from a sequence of human movements. We use the elements of a Switching Linear Dynamic System model as building blocks to translate formal definitions and procedures from human movement analysis. Our approach provides a method for users with no expertise in signal processing to create models for movements using labeled dataset and later use it for automatic assessment. We validated our framework on preliminary tests involving six healthy adult subjects that executed common movements in functional tests and rehabilitation exercise sessions, such as sit-to-stand and lateral elevation of the arms and five elderly subjects, two of which with limited mobility, that executed the sit-to-stand movement. The proposed method worked on random motion sequences for the dual purpose of movement segmentation (accuracy of 72%-100%) and motor performance assessment (mean error of 0%-12%).

The development and testing of a linear induction motor being fed from the source with limited electric power

Science.gov (United States)

Tiunov, V. V.

2018-02-01

The report provides results of the research related to the tubular linear induction motors’ application. The motors’ design features, a calculation model, a description of test specimens for mining and electric power industry are introduced. The most attention is given to the single-phase motors for high voltage switches drives with the usage of inexpensive standard single-phase transformers for motors’ power supply. The method of the motor’s parameters determination, when the motor is being fed from the transformer, working in the overload mode, was described, and the results of it practical usage were good enough for the engineering practice.

Using a generalized linear mixed model approach to explore the role of age, motor proficiency, and cognitive styles in children's reach estimation accuracy.

Science.gov (United States)

Caçola, Priscila M; Pant, Mohan D

2014-10-01

The purpose was to use a multi-level statistical technique to analyze how children's age, motor proficiency, and cognitive styles interact to affect accuracy on reach estimation tasks via Motor Imagery and Visual Imagery. Results from the Generalized Linear Mixed Model analysis (GLMM) indicated that only the 7-year-old age group had significant random intercepts for both tasks. Motor proficiency predicted accuracy in reach tasks, and cognitive styles (object scale) predicted accuracy in the motor imagery task. GLMM analysis is suitable to explore age and other parameters of development. In this case, it allowed an assessment of motor proficiency interacting with age to shape how children represent, plan, and act on the environment.

FY 2000 report on the results of the technology development of energy use reduced machine tools, etc. Development of the linear motor system for realization of energy conservation and commercialization; 2000 nendo energy shiyo gorika kosaku kiki nado gijutsu kaihatsu seika hokokusho. Shoeneka to jitsuyoka wo jitsugensuru linear motor system no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

In relation to the drive system of machine tools widely used as production facilities for automobiles, home electric appliances, etc., the R and D were made of a high efficiency linear motor system of which attention was paid to energy rationalization and environmental loads, and the FY 2000 results were summed up. In the study of the development of the system, studies were made not only on the lowering of heating, cost reduction and heightening of speed, but on the mechanism and control by which machine natural vibration can relatively be cut off, technology of damping for cutting vibration, technology to meet the deformation, etc. by cutting loads, sliding loads, and acceleration of accelerating/decelerating, technology to reduce the machine weight, etc. In the study of the basic technology of linear motor, the finite element method analysis was conducted on the typical linear motor. Concerning the control system, specs were studied which can deal with natural vibration and cutting vibration of the machine system. As to the development of the steel scale type linear encoder, scale sample for evaluation of basic characteristics was designed/trially manufactured. In the study of the detection optical system, the design/trial manufacture of photodiode array were made. (NEDO)

Stepping Motor - Hydraulic Motor Servo Drives for an NC Milling ...

African Journals Online (AJOL)

In this paper the retrofit design of the control system of an NC milling machine with a stepping motor and stepping motor - actuated hydraulic motor servo mechanism on the machines X-axis is described. The servo designed in the course of this study was tested practically and shown to be linear - the velocity following errors ...

Importance of anisotropy in detachment rates for force production and cargo transport by a team of motor proteins.

Science.gov (United States)

Takshak, Anjneya; Kunwar, Ambarish

2016-05-01

Many cellular processes are driven by collective forces generated by a team consisting of multiple molecular motor proteins. One aspect that has received less attention is the detachment rate of molecular motors under mechanical force/load. While detachment rate of kinesin motors measured under backward force increases rapidly for forces beyond stall-force; this scenario is just reversed for non-yeast dynein motors where detachment rate from microtubule decreases, exhibiting a catch-bond type behavior. It has been shown recently that yeast dynein responds anisotropically to applied load, i.e. detachment rates are different under forward and backward pulling. Here, we use computational modeling to show that these anisotropic detachment rates might help yeast dynein motors to improve their collective force generation in the absence of catch-bond behavior. We further show that the travel distance of cargos would be longer if detachment rates are anisotropic. Our results suggest that anisotropic detachment rates could be an alternative strategy for motors to improve the transport properties and force production by the team. © 2016 The Protein Society.

MODELING OF EQUIVALENT STIFFNESS OF A MAGNETIC SPRING OF VIBRATION EXCITER BASED ON COAXIAL-LINEAR MOTOR

Directory of Open Access Journals (Sweden)

G.M. Golenkov

2015-12-01

Full Text Available Purpose. The research of the influence of value and direction of current on the equivalent spring magnetic force based on coaxial-linear motor (CLM – MS. Methodology. We carried out investigation of the equivalent harshness of magnetic spring with determination of electromechanical propulsion performance characteristics by the methods of computer modeling and experimental research of physical model of CLM – MS. The modeling of magnetic spring of CLM – MS is carried out by the finite-element method. The challenge is met as an axisymmetric challenge in cylindrical co-ordinates in magnetostatic approach. The experimental investigattion of the propulsion performance characteristics of magnetic spring is carried out on the test bench. Results. After the computer modeling and the experimental investigation of the electromechanical propulsion performance characteristics of magnetic spring the expressions of equivalent stiffness coefficient depending on the current in winding are obtained. The results of computer modeling are confirmed experimentally. Originality. The determination of equivalent stiffness coefficient of magnetic spring of vibration exciter based on coaxial-linear motor. Practical value. The obtained determination of equivalent stiffness coefficient of magnetic spring may be used in process of designing of vibration machines with devices for change of natural oscillation frequency.

A linear programming model for protein inference problem in shotgun proteomics.

Science.gov (United States)

Huang, Ting; He, Zengyou

2012-11-15

Assembling peptides identified from tandem mass spectra into a list of proteins, referred to as protein inference, is an important issue in shotgun proteomics. The objective of protein inference is to find a subset of proteins that are truly present in the sample. Although many methods have been proposed for protein inference, several issues such as peptide degeneracy still remain unsolved. In this article, we present a linear programming model for protein inference. In this model, we use a transformation of the joint probability that each peptide/protein pair is present in the sample as the variable. Then, both the peptide probability and protein probability can be expressed as a formula in terms of the linear combination of these variables. Based on this simple fact, the protein inference problem is formulated as an optimization problem: minimize the number of proteins with non-zero probabilities under the constraint that the difference between the calculated peptide probability and the peptide probability generated from peptide identification algorithms should be less than some threshold. This model addresses the peptide degeneracy issue by forcing some joint probability variables involving degenerate peptides to be zero in a rigorous manner. The corresponding inference algorithm is named as ProteinLP. We test the performance of ProteinLP on six datasets. Experimental results show that our method is competitive with the state-of-the-art protein inference algorithms. The source code of our algorithm is available at: https://sourceforge.net/projects/prolp/. zyhe@dlut.edu.cn. Supplementary data are available at Bioinformatics Online.

Using linear algebra for protein structural comparison and classification.

Science.gov (United States)

Gomide, Janaína; Melo-Minardi, Raquel; Dos Santos, Marcos Augusto; Neshich, Goran; Meira, Wagner; Lopes, Júlio César; Santoro, Marcelo

2009-07-01

In this article, we describe a novel methodology to extract semantic characteristics from protein structures using linear algebra in order to compose structural signature vectors which may be used efficiently to compare and classify protein structures into fold families. These signatures are built from the pattern of hydrophobic intrachain interactions using Singular Value Decomposition (SVD) and Latent Semantic Indexing (LSI) techniques. Considering proteins as documents and contacts as terms, we have built a retrieval system which is able to find conserved contacts in samples of myoglobin fold family and to retrieve these proteins among proteins of varied folds with precision of up to 80%. The classifier is a web tool available at our laboratory website. Users can search for similar chains from a specific PDB, view and compare their contact maps and browse their structures using a JMol plug-in.

Using linear algebra for protein structural comparison and classification

Directory of Open Access Journals (Sweden)

Janaína Gomide

2009-01-01

Full Text Available In this article, we describe a novel methodology to extract semantic characteristics from protein structures using linear algebra in order to compose structural signature vectors which may be used efficiently to compare and classify protein structures into fold families. These signatures are built from the pattern of hydrophobic intrachain interactions using Singular Value Decomposition (SVD and Latent Semantic Indexing (LSI techniques. Considering proteins as documents and contacts as terms, we have built a retrieval system which is able to find conserved contacts in samples of myoglobin fold family and to retrieve these proteins among proteins of varied folds with precision of up to 80%. The classifier is a web tool available at our laboratory website. Users can search for similar chains from a specific PDB, view and compare their contact maps and browse their structures using a JMol plug-in.

Low-Rank Linear Dynamical Systems for Motor Imagery EEG.

Science.gov (United States)

Zhang, Wenchang; Sun, Fuchun; Tan, Chuanqi; Liu, Shaobo

2016-01-01

The common spatial pattern (CSP) and other spatiospectral feature extraction methods have become the most effective and successful approaches to solve the problem of motor imagery electroencephalography (MI-EEG) pattern recognition from multichannel neural activity in recent years. However, these methods need a lot of preprocessing and postprocessing such as filtering, demean, and spatiospectral feature fusion, which influence the classification accuracy easily. In this paper, we utilize linear dynamical systems (LDSs) for EEG signals feature extraction and classification. LDSs model has lots of advantages such as simultaneous spatial and temporal feature matrix generation, free of preprocessing or postprocessing, and low cost. Furthermore, a low-rank matrix decomposition approach is introduced to get rid of noise and resting state component in order to improve the robustness of the system. Then, we propose a low-rank LDSs algorithm to decompose feature subspace of LDSs on finite Grassmannian and obtain a better performance. Extensive experiments are carried out on public dataset from "BCI Competition III Dataset IVa" and "BCI Competition IV Database 2a." The results show that our proposed three methods yield higher accuracies compared with prevailing approaches such as CSP and CSSP.

Human myosin VIIa is a very slow processive motor protein on various cellular actin structures.

Science.gov (United States)

Sato, Osamu; Komatsu, Satoshi; Sakai, Tsuyoshi; Tsukasaki, Yoshikazu; Tanaka, Ryosuke; Mizutani, Takeomi; Watanabe, Tomonobu M; Ikebe, Reiko; Ikebe, Mitsuo

2017-06-30

Human myosin VIIa (MYO7A) is an actin-linked motor protein associated with human Usher syndrome (USH) type 1B, which causes human congenital hearing and visual loss. Although it has been thought that the role of human myosin VIIa is critical for USH1 protein tethering with actin and transportation along actin bundles in inner-ear hair cells, myosin VIIa's motor function remains unclear. Here, we studied the motor function of the tail-truncated human myosin VIIa dimer (HM7AΔTail/LZ) at the single-molecule level. We found that the HM7AΔTail/LZ moves processively on single actin filaments with a step size of 35 nm. Dwell-time distribution analysis indicated an average waiting time of 3.4 s, yielding ∼0.3 s -1 for the mechanical turnover rate; hence, the velocity of HM7AΔTail/LZ was extremely slow, at 11 nm·s -1 We also examined HM7AΔTail/LZ movement on various actin structures in demembranated cells. HM7AΔTail/LZ showed unidirectional movement on actin structures at cell edges, such as lamellipodia and filopodia. However, HM7AΔTail/LZ frequently missed steps on actin tracks and exhibited bidirectional movement at stress fibers, which was not observed with tail-truncated myosin Va. These results suggest that the movement of the human myosin VIIa motor protein is more efficient on lamellipodial and filopodial actin tracks than on stress fibers, which are composed of actin filaments with different polarity, and that the actin structures influence the characteristics of cargo transportation by human myosin VIIa. In conclusion, myosin VIIa movement appears to be suitable for translocating USH1 proteins on stereocilia actin bundles in inner-ear hair cells. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Non-linear dynamics in Parkinsonism

Directory of Open Access Journals (Sweden)

Olivier eDarbin

2013-12-01

Full Text Available Over the last 30 years, the functions (and dysfunctions of the sensory-motor circuitry have been mostly conceptualized using linear modelizations which have resulted in two main models: the "rate hypothesis" and the "oscillatory hypothesis". In these two models, the basal ganglia data stream is envisaged as a random temporal combination of independent simple patterns issued from its probability distribution of interval interspikes or its spectrum of frequencies respectively.More recently, non-linear analyses have been introduced in the modelization of motor circuitry activities, and they have provided evidences that complex temporal organizations exist in basal ganglia neuronal activities. Regarding movement disorders, these complex temporal organizations in the basal ganglia data stream differ between conditions (i.e. parkinsonism, dyskinesia, healthy control and are responsive to treatments (i.e. L-DOPA,DBS. A body of evidence has reported that basal ganglia neuronal entropy (a marker for complexity/irregularity in time series is higher in hypokinetic state. In line with these findings, an entropy-based model has been recently formulated to introduce basal ganglia entropy as a marker for the alteration of motor processing and a factor of motor inhibition. Importantly, non-linear features have also been identified as a marker of condition and/or treatment effects in brain global signals (EEG, muscular activities (EMG or kinetic of motor symptoms (tremor, gait of patients with movement disorders. It is therefore warranted that the non-linear dynamics of motor circuitry will contribute to a better understanding of the neuronal dysfunctions underlying the spectrum of parkinsonian motor symptoms including tremor, rigidity and hypokinesia.

Functionalized linear poly(amidoamine)s are efficient vectors for intracellular protein delivery

NARCIS (Netherlands)

Coué, G.M.J.P.C.; Engbersen, Johannes F.J.

2011-01-01

An effective intracellular protein delivery system was developed based on functionalized linear poly(amidoamine)s (PAAs) that form self-assembled cationic nanocomplexes with oppositely charged proteins. Three differently functionalized PAAs were synthesized, two of these having repetitive disulfide

Speed control of permanent magnet excitation transverse flux linear motor by using adaptive neuro-fuzzy controller

Energy Technology Data Exchange (ETDEWEB)

Hasanien, Hany M., E-mail: Hanyhasanien@ieee.or [Dept. of Elec. Power and Machines, Faculty of Eng., Ain-shams Univ. Cairo (Egypt); Muyeen, S.M. [Department of Electrical Engineering, Petroleum Institute, Abu Dhabi (United Arab Emirates); Tamura, Junji [Department of EEE, Kitami Institute of Technology, 165 Koen Cho, Kitami 090-8507, Hokkaido (Japan)

2010-12-15

This paper presents a novel adaptive neuro-fuzzy controller applies on transverse flux linear motor for controlling its speed. The proposed controller presents fuzzy logic controller with self tuning scaling factors based on artificial neural network structure. It has two input variables and one control output variable. Firstly the fuzzy logic control rules are described then NN architecture is represented to self tune the output scaling factors of the controller. The application of this control technique represents the novelty of work, where this algorithm has so far not been stated before for this type of drives. This methodology solves the problem of nonlinearities and load changes of TFLM drives. The dynamic response of the motor is studied under the rated load condition as well as load disturbances. The proposed controller ensures fast and accurate dynamic response with an excellent steady state performance. The dynamic response of the motor with the proposed controller is compared with PI and adaptive NN controllers. It is found that the proposed controller gives better and faster response from the viewpoint of overshoot and settling time. Matlab/Simulink tool is used for this dynamic simulation study.

The Multiple Correspondence Analysis Method and Brain Functional Connectivity: Its Application to the Study of the Non-linear Relationships of Motor Cortex and Basal Ganglia.

Science.gov (United States)

Rodriguez-Sabate, Clara; Morales, Ingrid; Sanchez, Alberto; Rodriguez, Manuel

2017-01-01

The complexity of basal ganglia (BG) interactions is often condensed into simple models mainly based on animal data and that present BG in closed-loop cortico-subcortical circuits of excitatory/inhibitory pathways which analyze the incoming cortical data and return the processed information to the cortex. This study was aimed at identifying functional relationships in the BG motor-loop of 24 healthy-subjects who provided written, informed consent and whose BOLD-activity was recorded by MRI methods. The analysis of the functional interaction between these centers by correlation techniques and multiple linear regression showed non-linear relationships which cannot be suitably addressed with these methods. The multiple correspondence analysis (MCA), an unsupervised multivariable procedure which can identify non-linear interactions, was used to study the functional connectivity of BG when subjects were at rest. Linear methods showed different functional interactions expected according to current BG models. MCA showed additional functional interactions which were not evident when using lineal methods. Seven functional configurations of BG were identified with MCA, two involving the primary motor and somatosensory cortex, one involving the deepest BG (external-internal globus pallidum, subthalamic nucleus and substantia nigral), one with the input-output BG centers (putamen and motor thalamus), two linking the input-output centers with other BG (external pallidum and subthalamic nucleus), and one linking the external pallidum and the substantia nigral. The results provide evidence that the non-linear MCA and linear methods are complementary and should be best used in conjunction to more fully understand the nature of functional connectivity of brain centers.

Revealing Linear Aggregates of Light Harvesting Antenna Proteins in Photosynthetic Membranes

OpenAIRE

He, Yufan; Zeng, Xiaohua; Mukherjee, Saptarshi; Rajapaksha, Suneth; Kaplan, Samuel; Lu, H. Peter

2010-01-01

How light energy is harvested in a natural photosynthetic membrane through energy transfer is closely related to the stoichiometry and arrangement of light harvesting antenna proteins in the membrane. The specific photosynthetic architecture facilitates a rapid and efficient energy transfer among the light harvesting proteins (LH2 and LH1) and to the reaction center. Here we report the identification of linear aggregates of light harvesting proteins, LH2, in the photosynthetic membranes under...

Branched-linear and agglomerate protein polymers as vaccine platforms.

Science.gov (United States)

Wang, Leyi; Xia, Ming; Huang, Pengwei; Fang, Hao; Cao, Dianjun; Meng, Xiang-Jin; McNeal, Monica; Jiang, Xi; Tan, Ming

2014-09-01

Many viral structural proteins and their truncated domains share a common feature of homotypic interaction forming dimers, trimers, and/or oligomers with various valences. We reported previously a simple strategy for construction of linear and network polymers through the dimerization feature of viral proteins for vaccine development. In this study, technologies were developed to produce more sophisticated polyvalent complexes through both the dimerization and oligomerization natures of viral antigens. As proof of concept, branched-linear and agglomerate polymers were made via fusions of the dimeric glutathione-s-transferase (GST) with either a tetrameric hepatitis E virus (HEV) protruding protein or a 24-meric norovirus (NoV) protruding protein. Furthermore, a monomeric antigen, either the M2e epitope of influenza A virus or the VP8* antigen of rotavirus, was inserted and displayed by the polymer platform. All resulting polymers were easily produced in Escherichia coli at high yields. Immunization of mice showed that the polymer vaccines induced significantly higher specific humoral and T cell responses than those induced by the dimeric antigens. Additional evidence in supporting use of polymer vaccines included the significantly higher neutralization activity and protective immunity of the polymer vaccines against the corresponding viruses than those of the dimer vaccines. Thus, our technology for production of polymers containing different viral antigens offers a strategy for vaccine development against infectious pathogens and their associated diseases. Copyright © 2014 Elsevier Ltd. All rights reserved.

Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus.

Directory of Open Access Journals (Sweden)

Filipa I Baptista

Full Text Available Diabetes mellitus is the most common metabolic disorder in humans. Diabetic encephalopathy is characterized by cognitive and memory impairments, which have been associated with changes in the hippocampus, but the mechanisms underlying those impairments triggered by diabetes, are far from being elucidated. The disruption of axonal transport is associated with several neurodegenerative diseases and might also play a role in diabetes-associated disorders affecting nervous system. We investigated the effect of diabetes (2 and 8 weeks duration on KIF1A, KIF5B and dynein motor proteins, which are important for axonal transport, in the hippocampus. The mRNA expression of motor proteins was assessed by qRT-PCR, and also their protein levels by immunohistochemistry in hippocampal slices and immunoblotting in total extracts of hippocampus from streptozotocin-induced diabetic and age-matched control animals. Diabetes increased the expression and immunoreactivity of KIF1A and KIF5B in the hippocampus, but no alterations in dynein were detected. Since hyperglycemia is considered a major player in diabetic complications, the effect of a prolonged exposure to high glucose on motor proteins, mitochondria and synaptic proteins in hippocampal neurons was also studied, giving particular attention to changes in axons. Hippocampal cell cultures were exposed to high glucose (50 mM or mannitol (osmotic control; 25 mM plus 25 mM glucose for 7 days. In hippocampal cultures incubated with high glucose no changes were detected in the fluorescence intensity or number of accumulations related with mitochondria in the axons of hippocampal neurons. Nevertheless, high glucose increased the number of fluorescent accumulations of KIF1A and synaptotagmin-1 and decreased KIF5B, SNAP-25 and synaptophysin immunoreactivity specifically in axons of hippocampal neurons. These changes suggest that anterograde axonal transport mediated by these kinesins may be impaired in hippocampal

Particle Swarm Based Approach of a Real-Time Discrete Neural Identifier for Linear Induction Motors

Directory of Open Access Journals (Sweden)

Alma Y. Alanis

2013-01-01

Full Text Available This paper focusses on a discrete-time neural identifier applied to a linear induction motor (LIM model, whose model is assumed to be unknown. This neural identifier is robust in presence of external and internal uncertainties. The proposed scheme is based on a discrete-time recurrent high-order neural network (RHONN trained with a novel algorithm based on extended Kalman filter (EKF and particle swarm optimization (PSO, using an online series-parallel con…figuration. Real-time results are included in order to illustrate the applicability of the proposed scheme.

Piezoelectric Motors, an Overview

OpenAIRE

Karl Spanner; Burhanettin Koc

2016-01-01

Piezoelectric motors are used in many industrial and commercial applications. Various piezoelectric motors are available in the market. All of the piezoelectric motors use the inverse piezoelectric effect, where microscopically small oscillatory motions are converted into continuous or stepping rotary or linear motions. Methods of obtaining long moving distance have various drive and functional principles that make these motors categorized into three groups: resonance-drive (piezoelectric ult...

Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease.

Science.gov (United States)

Fujita, Kengo; Ito, Hidefumi; Nakano, Satoshi; Kinoshita, Yoshimi; Wate, Reika; Kusaka, Hirofumi

2008-10-01

This report concerns an immunohistochemical investigation on RNA-related proteins in the basophilic inclusions (BIs) from patients with adult-onset atypical motor neuron disease. Formalin-fixed, paraffin-embedded sections of the motor cortex and the lumbar spinal cord were examined. The BIs appeared blue in color with H&E and Nissl stain, and pink with methylgreen-pyronin stain. Ribonuclease pretreatment abolished the methylgreen-pyronin staining, suggesting that the BIs contained RNA. Immunohistochemically, the BIs were distinctly labeled with the antibodies against poly(A)-binding protein 1, T cell intracellular antigen 1, and ribosomal protein S6. These proteins are essential constituents of stress granules. In contrast, the BIs were not immunoreactive for ribosomal protein L28 and decapping enzyme 1, which are core components of transport ribonucleoprotein particles and processing bodies, respectively. Moreover, the BIs were not immunopositive for TDP-43. Our results imply that translation attenuation could be involved in the processes of BI formation in this disorder.

AIRGAP MAGNETIC INDUCTION DISTRIBUTION IN A COAXIALLY-LINEAR SYNCHRONOUS MOTOR WITH AXIAL AND RADIAL DIRECTION OF THE RUNNER PERMANENT MAGNETS MAGNETIZATION

Directory of Open Access Journals (Sweden)

Abbasian Mohsen

2013-02-01

Full Text Available Results of theoretical and experimental research on magnetic induction distribution in the air gap of a coaxially-linear synchronous motor with reciprocal motion within the pole pitch and axial and radial direction of the permanent magnets magnetization are presented.

Experimental Analysis of Linear Induction Motor under Variable Voltage Variable Frequency (VVVF Power Supply

Directory of Open Access Journals (Sweden)

Prasenjit D. Wakode

2016-07-01

Full Text Available This paper presents the complete analysis of Linear Induction Motor (LIM under VVVF. The complete variation of LIM air gap flux under ‘blocked Linor’ condition and starting force is analyzed and presented when LIM is given VVVF supply. The analysis of this data is important in further understanding of the equivalent circuit parameters of LIM and to study the magnetic circuit of LIM. The variation of these parameters is important to know the LIM response at different frequencies. The simulation and application of different control strategies such as vector control thus becomes quite easy to apply and understand motor’s response under such strategy of control.

Rail Brake System Using a Linear Induction Motor for Dynamic Braking

Science.gov (United States)

Sakamoto, Yasuaki; Kashiwagi, Takayuki; Tanaka, Minoru; Hasegawa, Hitoshi; Sasakawa, Takashi; Fujii, Nobuo

One type of braking system for railway vehicles is the eddy current brake. Because this type of brake has the problem of rail heating, it has not been used for practical applications in Japan. Therefore, we proposed the use of a linear induction motor (LIM) for dynamic braking in eddy current brake systems. The LIM reduces rail heating and uses an inverter for self excitation. In this paper, we estimated the performance of an LIM from experimental results of a fundamental test machine and confirmed that the LIM generates an approximately constant braking force under constant current excitation. At relatively low frequencies, this braking force remains unaffected by frequency changes. The reduction ratio of rail heating is also approximately proportional to the frequency. We also confirmed that dynamic braking resulting in no electrical output can be used for drive control of the LIM. These characteristics are convenient for the realization of the LIM rail brake system.

Torque Ripple Reduction of a Novel Modular Arc-Linear Flux-Switching Permanent-Magnet Motor with Rotor Step Skewing

Directory of Open Access Journals (Sweden)

Xiangdong Liu

2016-05-01

Full Text Available A novel modular arc-linear flux-switching permanent-magnet motor (MAL-FSPM used for scanning system instead of reduction gearboxes and kinematic mechanisms is proposed and researched in this paper by the finite element method (FEM. The MAL-FSPM combines characteristics of flux-switching permanent-magnet motor and linear motor and can realize the direct driving and limited angular movement. Structure and operation principle of the MAL-FSPM are analyzed. Cogging torque model of the MAL-FSPM is established. The characteristics of cogging torque and torque ripple are investigated for: (1 distance (dend between left end of rotor and left end of stator is more than two rotor tooth pitch (τp; and (2 dend is less than two rotor tooth pitch. Cogging torque is an important component of torque ripple and the period ratio of the cogging torque to the back electromotive force (EMF equals one for the MAL-FSPM before optimization. In order to reduce the torque ripple as much as possible and affect the back EMF as little as possible, influence of period ratio of cogging torque to back EMF on rotor step skewing is investigated. Rotor tooth width and stator slot open width are optimized to increase the period ratio of cogging torque to back EMF. After the optimization, torque ripple is decreased by 79.8% for dend > τp and torque ripple is decreased by 49.7% for dend < τp. Finally, 3D FEM model is established to verify the 2D results.

Calculation of static characteristics of linear step motors for control rod drives of nuclear reactors - an approximate approach

International Nuclear Information System (INIS)

Khan, S.H.; Ivanov, A.A.

1993-01-01

This paper describes an approximate method for calculating the static characteristics of linear step motors (LSM), being developed for control rod drives (CRD) in large nuclear reactors. The static characteristic of such an LSM which is given by the variation of electromagnetic force with armature displacement determines the motor performance in its standing and dynamic modes. The approximate method of calculation of these characteristics is based on the permeance analysis method applied to the phase magnetic circuit of LSM. This is a simple, fast and efficient analytical approach which gives satisfactory results for small stator currents and weak iron saturation, typical to the standing mode of operation of LSM. The method is validated by comparing theoretical results with experimental ones. (Author)

Heterotrimeric Kinesin II Is the Microtubule Motor Protein Responsible for Pigment Dispersion in Xenopus Melanophores

Science.gov (United States)

Tuma, M. Carolina; Zill, Andrew; Le Bot, Nathalie; Vernos, Isabelle; Gelfand, Vladimir

1998-01-01

Melanophores move pigment organelles (melanosomes) from the cell center to the periphery and vice-versa. These bidirectional movements require cytoplasmic microtubules and microfilaments and depend on the function of microtubule motors and a myosin. Earlier we found that melanosomes purified from Xenopus melanophores contain the plus end microtubule motor kinesin II, indicating that it may be involved in dispersion (Rogers, S.L., I.S. Tint, P.C. Fanapour, and V.I. Gelfand. 1997. Proc. Natl. Acad. Sci. USA. 94: 3720–3725). Here, we generated a dominant-negative construct encoding green fluorescent protein fused to the stalk-tail region of Xenopus kinesin-like protein 3 (Xklp3), the 95-kD motor subunit of Xenopus kinesin II, and introduced it into melanophores. Overexpression of the fusion protein inhibited pigment dispersion but had no effect on aggregation. To control for the specificity of this effect, we studied the kinesin-dependent movement of lysosomes. Neither dispersion of lysosomes in acidic conditions nor their clustering under alkaline conditions was affected by the mutant Xklp3. Furthermore, microinjection of melanophores with SUK4, a function-blocking kinesin antibody, inhibited dispersion of lysosomes but had no effect on melanosome transport. We conclude that melanosome dispersion is powered by kinesin II and not by conventional kinesin. This paper demonstrates that kinesin II moves membrane-bound organelles. PMID:9852150

Sensor-Motor Maps for Describing Linear Reflex Composition in Hopping

Directory of Open Access Journals (Sweden)

Christian Schumacher

2017-11-01

Full Text Available In human and animal motor control several sensory organs contribute to a network of sensory pathways modulating the motion depending on the task and the phase of execution to generate daily motor tasks such as locomotion. To better understand the individual and joint contribution of reflex pathways in locomotor tasks, we developed a neuromuscular model that describes hopping movements. In this model, we consider the influence of proprioceptive length (LFB, velocity (VFB and force feedback (FFB pathways of a leg extensor muscle on hopping stability, performance and efficiency (metabolic effort. Therefore, we explore the space describing the blending of the monosynaptic reflex pathway gains. We call this reflex parameter space a sensor-motor map. The sensor-motor maps are used to visualize the functional contribution of sensory pathways in multisensory integration. We further evaluate the robustness of these sensor-motor maps to changes in tendon elasticity, body mass, segment length and ground compliance. The model predicted that different reflex pathway compositions selectively optimize specific hopping characteristics (e.g., performance and efficiency. Both FFB and LFB were pathways that enable hopping. FFB resulted in the largest hopping heights, LFB enhanced hopping efficiency and VFB had the ability to disable hopping. For the tested case, the topology of the sensor-motor maps as well as the location of functionally optimal compositions were invariant to changes in system designs (tendon elasticity, body mass, segment length or environmental parameters (ground compliance. Our results indicate that different feedback pathway compositions may serve different functional roles. The topology of the sensor-motor map was predicted to be robust against changes in the mechanical system design indicating that the reflex system can use different morphological designs, which does not apply for most robotic systems (for which the control often follows a

Sensor-Motor Maps for Describing Linear Reflex Composition in Hopping.

Science.gov (United States)

Schumacher, Christian; Seyfarth, André

2017-01-01

In human and animal motor control several sensory organs contribute to a network of sensory pathways modulating the motion depending on the task and the phase of execution to generate daily motor tasks such as locomotion. To better understand the individual and joint contribution of reflex pathways in locomotor tasks, we developed a neuromuscular model that describes hopping movements. In this model, we consider the influence of proprioceptive length (LFB), velocity (VFB) and force feedback (FFB) pathways of a leg extensor muscle on hopping stability, performance and efficiency (metabolic effort). Therefore, we explore the space describing the blending of the monosynaptic reflex pathway gains. We call this reflex parameter space a sensor-motor map . The sensor-motor maps are used to visualize the functional contribution of sensory pathways in multisensory integration. We further evaluate the robustness of these sensor-motor maps to changes in tendon elasticity, body mass, segment length and ground compliance. The model predicted that different reflex pathway compositions selectively optimize specific hopping characteristics (e.g., performance and efficiency). Both FFB and LFB were pathways that enable hopping. FFB resulted in the largest hopping heights, LFB enhanced hopping efficiency and VFB had the ability to disable hopping. For the tested case, the topology of the sensor-motor maps as well as the location of functionally optimal compositions were invariant to changes in system designs (tendon elasticity, body mass, segment length) or environmental parameters (ground compliance). Our results indicate that different feedback pathway compositions may serve different functional roles. The topology of the sensor-motor map was predicted to be robust against changes in the mechanical system design indicating that the reflex system can use different morphological designs, which does not apply for most robotic systems (for which the control often follows a specific

Experimental development of an ultrasonic linear motor

CSIR Research Space (South Africa)

M'Boungui, G

2010-01-01

Full Text Available the stator structure. In contrast to traditional travelling wave ultrasonic motors, which require two modes to be driven 90° out of phase, only one amplifier is required to drive the proposed device. A prototype device was characterised experimentally...

Comparison of experimental and theoretical reaction rail currents, rail voltages, and airgap fields for the linear induction motor research vehicle

Science.gov (United States)

Elliott, D. G.

1977-01-01

Measurements of reaction rail currents, reaction rail voltages, and airgap magnetic fields in tests of the Linear Induction Motor Research Vehicle (LIMRV) were compared with theoretical calculations from the mesh/matrix theory. It was found that the rail currents and magnetic fields predicted by the theory are within 20 percent of the measured currents and fields at most motor locations in most of the runs, but differ by as much as a factor of two in some cases. The most consistent difference is a higher experimental than theoretical magnetic field near the entrance of the motor and a lower experimental than theoretical magnetic field near the exit. The observed differences between the theoretical and experimental magnetic fields and currents do not account for the differences of as much as 26 percent between the theoretical and experimental thrusts.

A piezoelectric linear ultrasonic motor with the structure of a circular cylindrical stator and slider

International Nuclear Information System (INIS)

Sun, Dongming; Wang, Sheng; Sakurai, Junpei; Hata, Seiichi; Choi, Kee-Bong; Shimokohbe, Akira

2010-01-01

A piezoelectric linear ultrasonic motor is proposed, with a cylindrical stator and slider structure. The length and diameter of the motor are about 10 and 1.5 mm, respectively. The stator consists of two piezoelectric ceramic (PZT) tubes connected by a thin film metallic glass (TFMG) pipe. The stator is designed based on theoretical analyses and finite element method (FEM) simulation. The traveling wave propagation is obtained in the FEM simulation under the proper geometrical sizes, suitable boundary conditions and driving voltage signals. The trajectories of particles on the TFMG pipe are elliptical motion. In the experiment, a 25 µm thick TFMG pipe is fabricated using the rotating magnetron sputtering technique and the vibration characteristics of the stator are measured by a laser Doppler vibrometer (LDV) system. Bidirectional motion of the slider is observed around 600 kHz, the maximum velocity is near to 40 mm s −1 at 50 Vp–p for the loose slider and the maximum output force is 6 mN at 70 Vp–p for the tight slider

Motor skills training promotes motor functional recovery and induces synaptogenesis in the motor cortex and striatum after intracerebral hemorrhage in rats.

Science.gov (United States)

Tamakoshi, Keigo; Ishida, Akimasa; Takamatsu, Yasuyuki; Hamakawa, Michiru; Nakashima, Hiroki; Shimada, Haruka; Ishida, Kazuto

2014-03-01

We investigated the effects of motor skills training on several types of motor function and synaptic plasticity following intracerebral hemorrhage (ICH) in rats. Male Wistar rats were injected with collagenase into the left striatum to induce ICH, and they were randomly assigned to the ICH or sham groups. Each group was divided into the motor skills training (acrobatic training) and control (no exercise) groups. The acrobatic group performed acrobatic training from 4 to 28 days after surgery. Motor functions were assessed by motor deficit score, the horizontal ladder test and the wide or narrow beam walking test at several time points after ICH. The number of ΔFosB-positive cells was counted using immunohistochemistry to examine neuronal activation, and the PSD95 protein levels were analyzed by Western blotting to examine synaptic plasticity in the bilateral sensorimotor cortices and striata at 14 and 29 days after ICH. Motor skills training following ICH significantly improved gross motor function in the early phase after ICH and skilled motor coordinated function in the late phase. The number of ΔFosB-positive cells in the contralateral sensorimotor cortex in the acrobatic group significantly increased compared to the control group. PSD95 protein expression in the motor cortex significantly increased in the late phase, and in the striatum, the protein level significantly increased in the early phase by motor skills training after ICH compared to no training after ICH. We demonstrated that motor skills training improved motor function after ICH in rats and enhanced the neural activity and synaptic plasticity in the striatum and sensorimotor cortex. Copyright © 2013 Elsevier B.V. All rights reserved.

Application of the Hyper-Poisson Generalized Linear Model for Analyzing Motor Vehicle Crashes.

Science.gov (United States)

Khazraee, S Hadi; Sáez-Castillo, Antonio Jose; Geedipally, Srinivas Reddy; Lord, Dominique

2015-05-01

The hyper-Poisson distribution can handle both over- and underdispersion, and its generalized linear model formulation allows the dispersion of the distribution to be observation-specific and dependent on model covariates. This study's objective is to examine the potential applicability of a newly proposed generalized linear model framework for the hyper-Poisson distribution in analyzing motor vehicle crash count data. The hyper-Poisson generalized linear model was first fitted to intersection crash data from Toronto, characterized by overdispersion, and then to crash data from railway-highway crossings in Korea, characterized by underdispersion. The results of this study are promising. When fitted to the Toronto data set, the goodness-of-fit measures indicated that the hyper-Poisson model with a variable dispersion parameter provided a statistical fit as good as the traditional negative binomial model. The hyper-Poisson model was also successful in handling the underdispersed data from Korea; the model performed as well as the gamma probability model and the Conway-Maxwell-Poisson model previously developed for the same data set. The advantages of the hyper-Poisson model studied in this article are noteworthy. Unlike the negative binomial model, which has difficulties in handling underdispersed data, the hyper-Poisson model can handle both over- and underdispersed crash data. Although not a major issue for the Conway-Maxwell-Poisson model, the effect of each variable on the expected mean of crashes is easily interpretable in the case of this new model. © 2014 Society for Risk Analysis.

A T-shape linear piezoelectric motor with single foot.

Science.gov (United States)

Liu, Yingxiang; Chen, Weishan; Yang, Xiaohui; Liu, Junkao

2015-02-01

A new T-shape piezoelectric motor using the hybrid of two orthogonal longitudinal vibrations is proposed in this work. Six pieces of PZT ceramic plates are bonded on the upside and downside surfaces of a T-shape duralumin alloy base respectively to form the proposed motor. Elliptical movement can be generated on the driving tip by applying sine and cosine voltages to the PZT elements. The horizontal displacement of the driving tip will push the runner while the vertical displacement can overcome the preload. Finite element method is used to accomplish the design and analysis process. The resonance frequencies of the two vibration modes are tuned to be close by modal analysis, while the motion trajectory of the driving tip is observed by transient analysis. After the fabrication of a prototype, the vibration characteristics and mechanical output ability are measured. The no-load speed and the maximum output thrust force of the proposed motor are tested to be 718 mm/s and 3.5 N under an exciting frequency of 53.1 kHz. The proposed T-shape piezoelectric motor exhibits merits of simple structure, easy to realize miniaturization, easy to be fabricated, and high power-to-weight ratio. Copyright © 2014 Elsevier B.V. All rights reserved.

Improvement of superconducting cylindrical linear induction motor; Chodendo entokeitan ichiji rinia yudo mota no tokusei kaizen

Energy Technology Data Exchange (ETDEWEB)

Kikuma, T.; Tomita, M.; Ishiyama, A. [Waseda Univ., Tokyo (Japan)

1999-11-10

For the purpose of we examining the effect of characteristics and ac loss under real machine operating environment of the alternating current superconductivity winding for a realization of the superconductive AC machine vessel, cylindrical shortness first linear guiding motor which used NbTi/CuNi superconducting cable for the primary winding was produced experimentally. The coil number was increased from 6 in 14 this time, and the optimization of the primary current was done, and the improvement on characteristics was attempted. Here, starting torque characteristics, quenching detection protection control circuit are reported. (NEDO)

Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons

DEFF Research Database (Denmark)

Moldovan, Mihai; Alvarez Herrero, Susana; Pinchenko, Volodymyr

2011-01-01

Myelin protein zero mutations were found to produce Charcot-Marie-Tooth disease phenotypes with various degrees of myelin impairment and axonal loss, ranging from the mild 'demyelinating' adult form to severe and early onset forms. Protein zero deficient homozygous mice ( ) show a severe and prog......Myelin protein zero mutations were found to produce Charcot-Marie-Tooth disease phenotypes with various degrees of myelin impairment and axonal loss, ranging from the mild 'demyelinating' adult form to severe and early onset forms. Protein zero deficient homozygous mice ( ) show a severe...... and progressive dysmyelinating neuropathy from birth with compromised myelin compaction, hypomyelination and distal axonal degeneration. A previous study using immunofluorescence showed that motor nerves deficient of myelin protein zero upregulate the Na(V)1.8 voltage gated sodium channel isoform, which...... is normally present only in restricted populations of sensory axons. The aim of this study was to investigate the function of motor axons in protein zero-deficient mice with particular emphasis on ectopic Na(V)1.8 voltage gated sodium channel. We combined 'threshold tracking' excitability studies...

Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells

OpenAIRE

Iwatani, Sota; Harahap, Nur Imma Fatimah; Nurputra, Dian Kesumapramudya; Tairaku, Shinya; Shono, Akemi; Kurokawa, Daisuke; Yamana, Keiji; Thwin, Khin Kyae Mon; Yoshida, Makiko; Mizobuchi, Masami; Koda, Tsubasa; Fujioka, Kazumichi; Taniguchi-Ikeda, Mariko; Yamada, Hideto; Morioka, Ichiro

2017-01-01

Background: Spinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN) 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expressed and functionally linked to general RNA metabolism pathway, fibroblasts (FBs) are most widely used for the assessment of SMN expression in SMA patients but usually isolated from skin biopsy samples after the onset of overt sympt...

Versatile microsphere attachment of GFP-labeled motors and other tagged proteins with preserved functionality

Directory of Open Access Journals (Sweden)

Michael Bugiel

2015-11-01

Full Text Available Microspheres are often used as handles for protein purification or force spectroscopy. For example, optical tweezers apply forces on trapped particles to which motor proteins are attached. However, even though many attachment strategies exist, procedures are often limited to a particular biomolecule and prone to non-specific protein or surface attachment. Such interactions may lead to loss of protein functionality or microsphere clustering. Here, we describe a versatile coupling procedure for GFP-tagged proteins via a polyethylene glycol linker preserving the functionality of the coupled proteins. The procedure combines well-established protocols, is highly reproducible, reliable, and can be used for a large variety of proteins. The coupling is efficient and can be tuned to the desired microsphere-to-protein ratio. Moreover, microspheres hardly cluster or adhere to surfaces. Furthermore, the procedure can be adapted to different tags providing flexibility and a promising attachment strategy for any tagged protein.

Direct linear driving systems; Les entrainements lineaires directs

Energy Technology Data Exchange (ETDEWEB)

Favre, E.; Brunner, C.; Piaget, D. [ETEL SA (France)

1999-11-01

The linear motor is one of the most important developments in electrical drive technology. However, it only, began to be adopted on a large scale at the beginning of the 1990's and will not be considered a mature technology until well into the next millennium. Actuators based on linear motor technology have a number of technical advantages including high speed, high positional accuracy and fine resolution. They also require fewer component parts. Some precautions are necessary when using linear motors. Care must be taken to avoid overheating and excessive vibration, and the magnetic components must be protected.

Control of non-conventional synchronous motors

CERN Document Server

Louis, Jean-Paul

2013-01-01

Classical synchronous motors are the most effective device to drive industrial production systems and robots with precision and rapidity. However, numerous applications require efficient controls in non-conventional situations. Firstly, this is the case with synchronous motors supplied by thyristor line-commutated inverters, or with synchronous motors with faults on one or several phases. Secondly, many drive systems use non-conventional motors such as polyphase (more than three phases) synchronous motors, synchronous motors with double excitation, permanent magnet linear synchronous motors,

A study on stable levitation of permanent magnet transportation system with coreless linear synchronous motor

Energy Technology Data Exchange (ETDEWEB)

Hiwaki, H [Dept. of Electrical and Electronic Engineering, Musashi Inst. of Technology, Tokyo (Japan); Watada, M [Dept. of Electrical and Electronic Engineering, Musashi Inst. of Technology, Tokyo (Japan); Torii, S [Dept. of Electrical and Electronic Engineering, Musashi Inst. of Technology, Tokyo (Japan); Ebihara, D [Dept. of Electrical and Electronic Engineering, Musashi Inst. of Technology, Tokyo (Japan)

1996-12-31

In the permanent magnet levitation system, it is impossible to stabilize the motion of the vehicle in both levitation and guidance directions only by permanent magnet. Therefore, the authors proposed the combined system of permanent magnet for levitation and coreless linear synchronous motor (coreless LSM). To design the coreless coils for LSM, the method to calculate the spring coefficient between coreless coil and permanent magnet for LSM is shown. By using this method, the spring coefficients of the three coil arrangements are compared and coreless coil is designed. Furthermore, the authors showed the possibility of stabilizing the motion of the levitation system with coreless LSM. (orig.)

Incremental Adaptive Fuzzy Control for Sensorless Stroke Control of A Halbach-type Linear Oscillatory Motor

Science.gov (United States)

Lei, Meizhen; Wang, Liqiang

2018-01-01

The halbach-type linear oscillatory motor (HT-LOM) is multi-variable, highly coupled, nonlinear and uncertain, and difficult to get a satisfied result by conventional PID control. An incremental adaptive fuzzy controller (IAFC) for stroke tracking was presented, which combined the merits of PID control, the fuzzy inference mechanism and the adaptive algorithm. The integral-operation is added to the conventional fuzzy control algorithm. The fuzzy scale factor can be online tuned according to the load force and stroke command. The simulation results indicate that the proposed control scheme can achieve satisfied stroke tracking performance and is robust with respect to parameter variations and external disturbance.

An analytical method for the calculation of static characteristics of linear step motors for control rod drives in nuclear reactors

International Nuclear Information System (INIS)

Khan, S.H.; Ivanov, A.A.

1995-01-01

An analytical method for calculating static characteristics of linear dc step motors (LSM) is described. These multiphase passive-armature motors are now being developed for control rod drives (CRD) in large nuclear reactors. The static characteristics of such LSM is defined by the variation of electromagnetic force with armature displacement and it determines motor performance in its standing and dynamic modes of operation. The proposed analytical technique for calculating this characteristic is based on the permeance analysis method applied to phase magnetic circuits of LSM. Reluctances of various parts of phase magnetic circuit is calculated analytically by assuming probable flux paths and by taking into account complex nature of magnetic field distribution in it. For given armature positions stator and armature iron saturations are taken into account by an efficient iterative algorithm which gives fast convergence. The method is validated by comparing theoretical results with experimental ones which shows satisfactory agreement for small stator currents and weak iron saturation

Analysis and measure of novel stereo-garage driven by linear induction motor

Directory of Open Access Journals (Sweden)

Lu Qinfen

2015-12-01

Full Text Available The car access time is a key parameter, especially in a huge stereo-garage, where this one should be decreased as much as possible. This paper proposes a novel stereo-garage. Adopting the linear induction motors (LIMs, the system has a simple structure and rapid response capability. In the stereo-garage, several LIMs are installed below the crossbeam on a lifting platform, and several LIMs are fixed on the top of a moving frame. During the operation of LIMs, the moving frame moves forward and backward to reach the required parking place, whereas the crossbeam moves horizontally in order to take or store the vehicle rapidly. All these LIMs are the same and should be designed at a low frequency. The influences of key structure parameters and dynamic performances are investigated, based on FEM. The predicted results are validated by a prototype. Finally, the designed LIMs are successfully applied in two 8-layer stereo-garages.

Piezoelectric Motors, an Overview

Directory of Open Access Journals (Sweden)

Karl Spanner

2016-02-01

Full Text Available Piezoelectric motors are used in many industrial and commercial applications. Various piezoelectric motors are available in the market. All of the piezoelectric motors use the inverse piezoelectric effect, where microscopically small oscillatory motions are converted into continuous or stepping rotary or linear motions. Methods of obtaining long moving distance have various drive and functional principles that make these motors categorized into three groups: resonance-drive (piezoelectric ultrasonic motors, inertia-drive, and piezo-walk-drive. In this review, a comprehensive summary of piezoelectric motors, with their classification from initial idea to recent progress, is presented. This review also includes some of the industrial and commercial applications of piezoelectric motors that are presently available in the market as actuators.

Linearization of the Bradford protein assay to application in cow milk proteins quantification by UV-Vis spectrophotometry method.

OpenAIRE

SANTOS, A. S. de O. dos; COSTA, F. F.; ESTEVES, W. T.; BRITO, M. A. V. P. e; FURTADO, M. A. M.; MARTINS, M. F.

2015-01-01

Reliable methods for determination and quantification of total protein in food are essential information to ensure quality and safety of food trade. The objective of this study was to evaluate the linearity of calibration curves obtained from different proteins (blood serum albumin-BSA, α-LA, β-LG, αs, β and κ-CAS) with the reagent of Bradford. Comercial UHT skimmed bovine milk was analyzed for the determination of total protein using the Bradford method by reading at 595 nm. The determinatio...

Effect of milk proteins on linear growth and IGF variables in overweight adolescents

DEFF Research Database (Denmark)

Larnkjær, Anni; Arnberg, Karina; Michaelsen, Kim F

2014-01-01

Milk may stimulate growth acting via insulin-like growth factor-I (IGF-I) secretion but the effect in adolescents is less examined. This study investigates the effect of milk proteins on linear growth, IGF-I, IGF binding protein-3 (IGFBP-3) and IGF-I/IGFBP-3 ratio in overweight adolescents....

Artificial molecular motors

NARCIS (Netherlands)

Kassem, Salma; van Leeuwen, Thomas; Lubbe, Anouk S.; Wilson, Miriam R.; Feringa, Ben L.; Leigh, David A.

2017-01-01

Motor proteins are nature's solution for directing movement at the molecular level. The field of artificial molecular motors takes inspiration from these tiny but powerful machines. Although directional motion on the nanoscale performed by synthetic molecular machines is a relatively new

Linear pneumatic actuator

OpenAIRE

Avram Mihai; Niţu Constantin; Bucşan Constantin; Grămescu Bogdan

2017-01-01

The paper presents a linear pneumatic actuator with short working stroke. It consists of a pneumatic motor (a simple stroke cylinder or a membrane chamber), two 2/2 pneumatic distributors “all or nothing” electrically commanded for controlling the intake/outtake flow to/from the active chamber of the motor, a position transducer and a microcontroller. There is also presented the theoretical analysis (mathematical modelling and numerical simulation) accomplished.

Motor Behavior: From Telegraph Keys and Twins to Linear Slides and Stepping

Science.gov (United States)

Thomas, Jerry R.

2006-01-01

Motor behavior is a significant area of scholarship with 64 Fellows from the American Academy of Kinesiology and Physical Education engaged in that work since 1930. This paper provides a brief overview of the history of research in motor development and motor control/learning, particularly noting the contributions to scholarship of Academy…

Subcellular localization for Gram positive and Gram negative bacterial proteins using linear interpolation smoothing model.

Science.gov (United States)

Saini, Harsh; Raicar, Gaurav; Dehzangi, Abdollah; Lal, Sunil; Sharma, Alok

2015-12-07

Protein subcellular localization is an important topic in proteomics since it is related to a protein׳s overall function, helps in the understanding of metabolic pathways, and in drug design and discovery. In this paper, a basic approximation technique from natural language processing called the linear interpolation smoothing model is applied for predicting protein subcellular localizations. The proposed approach extracts features from syntactical information in protein sequences to build probabilistic profiles using dependency models, which are used in linear interpolation to determine how likely is a sequence to belong to a particular subcellular location. This technique builds a statistical model based on maximum likelihood. It is able to deal effectively with high dimensionality that hinders other traditional classifiers such as Support Vector Machines or k-Nearest Neighbours without sacrificing performance. This approach has been evaluated by predicting subcellular localizations of Gram positive and Gram negative bacterial proteins. Copyright © 2015 Elsevier Ltd. All rights reserved.

Fluid powered linear piston motor with harmonic coupling

Science.gov (United States)

Raymond, David W.

2016-09-20

A motor is disclosed that includes a module assembly including a piston that is axially cycled. The piston axial motion is coupled to torque couplers that convert the axial motion into rotary motion. The torque couplers are coupled to a rotor to rotate the rotor.

Persistent current analysis of superconducting coils in a linear synchronous motor for maglev passenger transport system. Fujoshiki tetsudoyo linear doki motor ni okeru teijisoku mode chodendo coil denryu no kaiseki

Energy Technology Data Exchange (ETDEWEB)

Azusawa, T [Toshiba Corp., Tokyo (Japan)

1994-05-20

The simple analysis method of persistent current induced in on-board superconducting coils was proposed for the vehicle of a superconducting magnetically-suspended train which is running in the magnetic field generated by armature coil current of a linear synchronous motor installed along a guideway, and the performance of the method is discussed through calculation based on typical models. As fluctuation of persistent current due to running was calculated with various parameter values under a normal running condition, fluctuation of persistent current induced was less then 1% of an initial magnetomotive force, having no adverse effect on the stability and reliability of superconducting magnets. Electromagnetic forces under a normal running condition could be predicted accurately enough by relatively easy-to-calculate constant current mode analysis. Double-layered armature coils were preferred to single-layered ones to enhance the stability of superconducting magnets by reducing fluctuation of persistent current. 10 refs., 8 figs., 1 tab.

Protein synthesis is essential not only for consolidation but also for maintenance and post-retrieval reconsolidation of acrobatic motor skill in rats.

Science.gov (United States)

Peng, Ji-Yun; Li, Bao-Ming

2009-05-28

It has been reported that consolidation of motor skill, a type of non-declarative memories, requires protein synthesis, as hippocampus-dependent declarative memory does. However, little is known about the importance of protein synthesis in maintenance and especially post-retrieval reconsolidation of acrobatic motor skill. Here, we show that protein synthesis is essential not only for the consolidation but also for the maintenance and reconsolidation of a rotarod-running skill. Intra-ventricle infusion of the protein synthesis inhibitor anisomycin 0 h but not 2 h post-training caused a severe deficit in the acquisition of the rotarod-running skill. Protein synthesis inhibition (PSI) also caused a deficit in the maintenance of the rotarod-running skill, as well-trained rats demonstrated a deficit in the rotarod-running performance upon treatment with anisomycin. Similarly, PSI impaired the post-retrieval reconsolidation of the rotarod-running skill: well-trained rats treated with anisomycin 0 h but not 0.5, 2 and 4 h after the task performance exhibited amnesia for the running skill later on. Interestingly, rats treated with anisomycin 6 and 12 h post-retrieval exhibited amnesia for the running skill. Thus, protein synthesis is essential not only for the consolidation but also for the maintenance and post-retrieval reconsolidation of rotarod-running acrobatic motor skill.

Lift force fluctuations of magnetically levitated vehicles with an integrated synchronous linear motor and their significance for the technical security

Energy Technology Data Exchange (ETDEWEB)

Mnich, P; Huebner, K D

1980-07-15

In this paper the influence of the motor current on the magnetic force is investigated by an analytical method. With the integrated synchronous linear motor the reactions of the current sheet on the excitation field are depending on the pole angle and the amplitude of the current sheet. For an undisturbed operation - current sheet and induction wave in phase - the influence of the motor current on the magnetic force can be neglected. In case of a disturbed performance, i.e. when the pole angle is changing periodically, fluctuations of the magnetic force will be found. This effect has to be compensated by a reserve magnetic force in the levitation control. With the technical data for the new magnetic levitation pilots plants (International Traffic Fair 1979 at Hamburg and Transrapid - Pilot Plant Emsland) the stated relations are evaluated. Approximated relations for the levitation force are derived. For comparison, a finite-difference computer programme from the 'Institut fuer elektrische Maschinen, Antriebe und Bahnen, Technische Universitaet Braunschweig' is applied. The approximated relations developed in this paper are verified - with a sufficient precision - by the numerical calculations.

Controllable molecular motors engineered from myosin and RNA

Science.gov (United States)

Omabegho, Tosan; Gurel, Pinar S.; Cheng, Clarence Y.; Kim, Laura Y.; Ruijgrok, Paul V.; Das, Rhiju; Alushin, Gregory M.; Bryant, Zev

2018-01-01

Engineering biomolecular motors can provide direct tests of structure-function relationships and customized components for controlling molecular transport in artificial systems1 or in living cells2. Previously, synthetic nucleic acid motors3-5 and modified natural protein motors6-10 have been developed in separate complementary strategies to achieve tunable and controllable motor function. Integrating protein and nucleic-acid components to form engineered nucleoprotein motors may enable additional sophisticated functionalities. However, this potential has only begun to be explored in pioneering work harnessing DNA scaffolds to dictate the spacing, number and composition of tethered protein motors11-15. Here, we describe myosin motors that incorporate RNA lever arms, forming hybrid assemblies in which conformational changes in the protein motor domain are amplified and redirected by nucleic acid structures. The RNA lever arm geometry determines the speed and direction of motor transport and can be dynamically controlled using programmed transitions in the lever arm structure7,9. We have characterized the hybrid motors using in vitro motility assays, single-molecule tracking, cryo-electron microscopy and structural probing16. Our designs include nucleoprotein motors that reversibly change direction in response to oligonucleotides that drive strand-displacement17 reactions. In multimeric assemblies, the controllable motors walk processively along actin filaments at speeds of 10-20 nm s-1. Finally, to illustrate the potential for multiplexed addressable control, we demonstrate sequence-specific responses of RNA variants to oligonucleotide signals.

Linear pneumatic actuator

Directory of Open Access Journals (Sweden)

Avram Mihai

2017-01-01

Full Text Available The paper presents a linear pneumatic actuator with short working stroke. It consists of a pneumatic motor (a simple stroke cylinder or a membrane chamber, two 2/2 pneumatic distributors “all or nothing” electrically commanded for controlling the intake/outtake flow to/from the active chamber of the motor, a position transducer and a microcontroller. There is also presented the theoretical analysis (mathematical modelling and numerical simulation accomplished.

A Model for Analyzing a Five-Phase Fractional-Slot Permanent Magnet Tubular Linear Motor with Modified Winding Function Approach

Directory of Open Access Journals (Sweden)

Bo Zhang

2016-01-01

Full Text Available This paper presents a model for analyzing a five-phase fractional-slot permanent magnet tubular linear motor (FSPMTLM with the modified winding function approach (MWFA. MWFA is a fast modeling method and it gives deep insight into the calculations of the following parameters: air-gap magnetic field, inductances, flux linkages, and detent force, which are essential in modeling the motor. First, using a magnetic circuit model, the air-gap magnetic density is computed from stator magnetomotive force (MMF, flux barrier, and mover geometry. Second, the inductances, flux linkages, and detent force are analytically calculated using modified winding function and the air-gap magnetic density. Finally, a model has been established with the five-phase Park transformation and simulated. The calculations of detent force reveal that the end-effect force is the main component of the detent force. This is also proven by finite element analysis on the motor. The accuracy of the model is validated by comparing with the results obtained using semianalytical method (SAM and measurements to analyze the motor’s transient characteristics. In addition, the proposed method requires less computation time.

GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

Directory of Open Access Journals (Sweden)

Chia-Shan Wu

Full Text Available The G-protein coupled receptor 55 (GPR55 is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology. However, little is known about the role of GPR55 in CNS development and function. To address this question, we performed a detailed characterization of GPR55 knockout mice using molecular, anatomical, electrophysiological, and behavioral assays. Quantitative PCR studies found that GPR55 mRNA was expressed (in order of decreasing abundance in the striatum, hippocampus, forebrain, cortex, and cerebellum. GPR55 deficiency did not affect the concentrations of endocannabinoids and related lipids or mRNA levels for several components of the endocannabinoid system in the hippocampus. Normal synaptic transmission and short-term as well as long-term synaptic plasticity were found in GPR55 knockout CA1 pyramidal neurons. Deleting GPR55 function did not affect behavioral assays assessing muscle strength, gross motor skills, sensory-motor integration, motor learning, anxiety or depressive behaviors. In addition, GPR55 null mutant mice exhibited normal contextual and auditory-cue conditioned fear learning and memory in a Pavlovian conditioned fear test. In contrast, when presented with tasks requiring more challenging motor responses, GPR55 knockout mice showed impaired movement coordination. Taken together, these results suggest that GPR55 plays a role in motor coordination, but does not strongly regulate CNS development, gross motor movement or several types of learned behavior.

GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

Science.gov (United States)

Wu, Chia-Shan; Chen, Hongmei; Sun, Hao; Zhu, Jie; Jew, Chris P; Wager-Miller, James; Straiker, Alex; Spencer, Corinne; Bradshaw, Heather; Mackie, Ken; Lu, Hui-Chen

2013-01-01

The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology. However, little is known about the role of GPR55 in CNS development and function. To address this question, we performed a detailed characterization of GPR55 knockout mice using molecular, anatomical, electrophysiological, and behavioral assays. Quantitative PCR studies found that GPR55 mRNA was expressed (in order of decreasing abundance) in the striatum, hippocampus, forebrain, cortex, and cerebellum. GPR55 deficiency did not affect the concentrations of endocannabinoids and related lipids or mRNA levels for several components of the endocannabinoid system in the hippocampus. Normal synaptic transmission and short-term as well as long-term synaptic plasticity were found in GPR55 knockout CA1 pyramidal neurons. Deleting GPR55 function did not affect behavioral assays assessing muscle strength, gross motor skills, sensory-motor integration, motor learning, anxiety or depressive behaviors. In addition, GPR55 null mutant mice exhibited normal contextual and auditory-cue conditioned fear learning and memory in a Pavlovian conditioned fear test. In contrast, when presented with tasks requiring more challenging motor responses, GPR55 knockout mice showed impaired movement coordination. Taken together, these results suggest that GPR55 plays a role in motor coordination, but does not strongly regulate CNS development, gross motor movement or several types of learned behavior.

Motor Importance of motor assessment in school children: analysis of the reliability of the motor development scale

Directory of Open Access Journals (Sweden)

Kassandra Nunes Amaro

2010-09-01

Full Text Available The objective of this study was to investigate the motor performance of school chil-dren aged 6 to 10 years without learning difficulties (n=101, and to analyze the reliability of the Motor Development Scale (MDS (Rosa Neto, 2002. Descriptive statistics with calculation of the mean, standard deviation, and range was used for data analysis. The internal consistency of the MDS was assessed using Cronbach’s alpha coefficient, and the correlation between variables was determined by Pearson’s linear correlation, with p<0.05. The results showed (1 that motor development was within normal limits in 96% of the children, and (2 a high correlation betwe-en chronological age and general motor age, indicating good internal consistency. These data demonstrate the logic and structured design of the MDS, confirming its reliability.

Linear methods for reducing EMG contamination in peripheral nerve motor decodes.

Science.gov (United States)

Kagan, Zachary B; Wendelken, Suzanne; Page, David M; Davis, Tyler; Hutchinson, Douglas T; Clark, Gregory A; Warren, David J

2016-08-01

Signals recorded from the peripheral nervous system (PNS) with high channel count penetrating microelectrode arrays, such as the Utah Slanted Electrode Array (USEA), often have electromyographic (EMG) signals contaminating the neural signal. This common-mode signal source may prevent single neural units from successfully being detected, thus hindering motor decode algorithms. Reducing this EMG contamination may lead to more accurate motor decode performance. A virtual reference (VR), created by a weighted linear combination of signals from a subset of all available channels, can be used to reduce this EMG contamination. Four methods of determining individual channel weights and six different methods of selecting subsets of channels were investigated (24 different VR types in total). The methods of determining individual channel weights were equal weighting, regression-based weighting, and two different proximity-based weightings. The subsets of channels were selected by a radius-based criteria, such that a channel was included if it was within a particular radius of inclusion from the target channel. These six radii of inclusion were 1.5, 2.9, 3.2, 5, 8.4, and 12.8 electrode-distances; the 12.8 electrode radius includes all USEA electrodes. We found that application of a VR improves the detectability of neural events via increasing the SNR, but we found no statistically meaningful difference amongst the VR types we examined. The computational complexity of implementation varies with respect to the method of determining channel weights and the number of channels in a subset, but does not correlate with VR performance. Hence, we examined the computational costs of calculating and applying the VR and based on these criteria, we recommend an equal weighting method of assigning weights with a 3.2 electrode-distance radius of inclusion. Further, we found empirically that application of the recommended VR will require less than 1 ms for 33.3 ms of data from one USEA.

Research on linear driving of wave maker; Zoha sochi no linear drive ka kenkyu

Energy Technology Data Exchange (ETDEWEB)

Yamamoto, I; Taniguchi, S; Nohara, T [Mitsubishi Heavy Industries, Ltd., Tokyo (Japan)

1997-10-01

The water tank test of marine structures or submarine structures uses a wave maker to generate waves. A typical flap wave maker uses the wave making flap penetrating a water surface whose bottom is fixed on a tank bottom through a hinge, and the top is connected with a rod driven by rotating servomotor for reciprocating motion of the flap. However, this driving gear using a rotating servomotor and a bowl- screw has some defects such as noise caused by bowl rotation, backlash due to wear and limited driving speed. A linear motor with less friction mechanisms was thus applied to the driving gear. The performance test result of the prototype driving gear using a linear motor showed the possibility of the linear driven wave maker. The linear driven wave maker could also achieve low noise and simple mechanism. The sufficient durability and applicability of the linear driven wave maker mechanism were confirmed through strength calculation necessary for improving the prototype wave maker. 1 ref., 5 figs., 2 tabs.

Functional recovery of regenerating motor axons is delayed in mice heterozygously deficient for the myelin protein P(0) gene

DEFF Research Database (Denmark)

Rosberg, Mette Romer; Alvarez, Susana; Krarup, Christian

2013-01-01

Mice with a heterozygous knock-out of the myelin protein P0 gene (P0+/-) develop a neuropathy similar to human Charcot-Marie-Tooth disease. They are indistinguishable from wild-types (WT) at birth and develop a slowly progressing demyelinating neuropathy. The aim of this study was to investigate...... whether the regeneration capacity of early symptomatic P0+/- is impaired as compared to age matched WT. Right sciatic nerves were lesioned at the thigh in 7-8 months old mice. Tibial motor axons at ankle were investigated by conventional motor conduction studies and axon excitability studies using...... threshold tracking. To evaluate regeneration we monitored the recovery of motor function after crush, and then compared the fiber distribution by histology. The overall motor performance was investigated using Rotor-Rod. P0+/- had reduced compound motor action potential amplitudes and thinner myelinated...

The UNC-4 homeobox protein represses mab-9 expression in DA motor neurons in Caenorhabditis elegans

DEFF Research Database (Denmark)

Jafari, Gholamali; Appleford, Peter J; Seago, Julian

2011-01-01

, an RNAi screen designed to identify upstream transcriptional regulators of mab-9 showed that silencing of unc-4 (encoding a paired-class homeodomain protein) increases mab-9::gfp expression in the nervous system, specifically in posterior DA motor neurons. Over-expression of unc-4 from a heat...

Protein fiber linear dichroism for structure determination and kinetics in a low-volume, low-wavelength couette flow cell.

Science.gov (United States)

Dafforn, Timothy R; Rajendra, Jacindra; Halsall, David J; Serpell, Louise C; Rodger, Alison

2004-01-01

High-resolution structure determination of soluble globular proteins relies heavily on x-ray crystallography techniques. Such an approach is often ineffective for investigations into the structure of fibrous proteins as these proteins generally do not crystallize. Thus investigations into fibrous protein structure have relied on less direct methods such as x-ray fiber diffraction and circular dichroism. Ultraviolet linear dichroism has the potential to provide additional information on the structure of such biomolecular systems. However, existing systems are not optimized for the requirements of fibrous proteins. We have designed and built a low-volume (200 microL), low-wavelength (down to 180 nm), low-pathlength (100 microm), high-alignment flow-alignment system (couette) to perform ultraviolet linear dichroism studies on the fibers formed by a range of biomolecules. The apparatus has been tested using a number of proteins for which longer wavelength linear dichroism spectra had already been measured. The new couette cell has also been used to obtain data on two medically important protein fibers, the all-beta-sheet amyloid fibers of the Alzheimer's derived protein Abeta and the long-chain assemblies of alpha1-antitrypsin polymers.

Selective cell-surface labeling of the molecular motor protein prestin

International Nuclear Information System (INIS)

McGuire, Ryan M.; Silberg, Jonathan J.; Pereira, Fred A.; Raphael, Robert M.

2011-01-01

Highlights: → Trafficking to the plasma membrane is required for prestin function. → Biotin acceptor peptide (BAP) was fused to prestin through a transmembrane domain. → BAP-prestin can be metabolically labeled with biotin in HEK293 cells. → Biotin-BAP-prestin allows for selective imaging of fully trafficked prestin. → The biotin-BAP-prestin displays voltage-sensitive activity. -- Abstract: Prestin, a multipass transmembrane protein whose N- and C-termini are localized to the cytoplasm, must be trafficked to the plasma membrane to fulfill its cellular function as a molecular motor. One challenge in studying prestin sequence-function relationships within living cells is separating the effects of amino acid substitutions on prestin trafficking, plasma membrane localization and function. To develop an approach for directly assessing prestin levels at the plasma membrane, we have investigated whether fusion of prestin to a single pass transmembrane protein results in a functional fusion protein with a surface-exposed N-terminal tag that can be detected in living cells. We find that fusion of the biotin-acceptor peptide (BAP) and transmembrane domain of the platelet-derived growth factor receptor (PDGFR) to the N-terminus of prestin-GFP yields a membrane protein that can be metabolically-labeled with biotin, trafficked to the plasma membrane, and selectively detected at the plasma membrane using fluorescently-tagged streptavidin. Furthermore, we show that the addition of a surface detectable tag and a single-pass transmembrane domain to prestin does not disrupt its voltage-sensitive activity.

AC Application of HTS Conductors in Highly Dynamic Electric Motors

International Nuclear Information System (INIS)

Oswald, B; Best, K-J; Setzer, M; Duffner, E; Soell, M; Gawalek, W; Kovalev, L K

2006-01-01

Based on recent investigations we design highly dynamic electric motors up to 400 kW and linear motors up to 120 kN linear force using HTS bulk material and HTS tapes. The introduction of HTS tapes into AC applications in electric motors needs fundamental studies on double pancake coils under transversal magnetic fields. First theoretical and experimental results on AC field distributions in double-pancake-coils and corresponding AC losses will be presented. Based on these results the simulation of the motor performance confirms extremely high power density and efficiency of both types of electric motors. Improved characteristics of rare earth permanent magnets used in our motors at low temperatures give an additional technological benefit

Protein synthesis is essential not only for consolidation but also for maintenance and post-retrieval reconsolidation of acrobatic motor skill in rats

Directory of Open Access Journals (Sweden)

Peng Ji-Yun

2009-05-01

Full Text Available Abstract It has been reported that consolidation of motor skill, a type of non-declarative memories, requires protein synthesis, as hippocampus-dependent declarative memory does. However, little is known about the importance of protein synthesis in maintenance and especially post-retrieval reconsolidation of acrobatic motor skill. Here, we show that protein synthesis is essential not only for the consolidation but also for the maintenance and reconsolidation of a rotarod-running skill. Intra-ventricle infusion of the protein synthesis inhibitor anisomycin 0 h but not 2 h post-training caused a severe deficit in the acquisition of the rotarod-running skill. Protein synthesis inhibition (PSI also caused a deficit in the maintenance of the rotarod-running skill, as well-trained rats demonstrated a deficit in the rotarod-running performance upon treatment with anisomycin. Similarly, PSI impaired the post-retrieval reconsolidation of the rotarod-running skill: well-trained rats treated with anisomycin 0 h but not 0.5, 2 and 4 h after the task performance exhibited amnesia for the running skill later on. Interestingly, rats treated with anisomycin 6 and 12 h post-retrieval exhibited amnesia for the running skill. Thus, protein synthesis is essential not only for the consolidation but also for the maintenance and post-retrieval reconsolidation of rotarod-running acrobatic motor skill.

Fluctuations in isometric muscle force can be described by one linear projection of low-frequency components of motor unit discharge rates.

Science.gov (United States)

Negro, Francesco; Holobar, Ales; Farina, Dario

2009-12-15

The aim of the study was to investigate the relation between linear transformations of motor unit discharge rates and muscle force. Intramuscular (wire electrodes) and high-density surface EMG (13 x 5 electrode grid) were recorded from the abductor digiti minimi muscle of eight healthy men during 60 s contractions at 5%, 7.5% and 10% of the maximal force. Spike trains of a total of 222 motor units were identified from the EMG recordings with decomposition algorithms. Principal component analysis of the smoothed motor unit discharge rates indicated that one component (first common component, FCC) described 44.2 +/- 7.5% of the total variability of the smoothed discharge rates when computed over the entire contraction interval and 64.3 +/- 10.2% of the variability when computed over 5 s intervals. When the FCC was computed from four or more motor units per contraction, it correlated with the force produced by the muscle (62.7 +/- 10.1%) by a greater degree (P FCC and the force signal increased up to 71.8 +/- 13.1% when the duration and the shape of the smoothing window for discharge rates were similar to the average motor unit twitch force. Moreover, the coefficients of variation (CoV) for the force and for the FCC signal were correlated in all subjects (R(2) range = 0.14-0.56; P measures on the tibialis anterior muscle of an additional eight subjects during contractions at forces up to 20% of the maximal force (e.g. FCC explained 59.8 +/- 11.0% of variability of the smoothed discharge rates). In conclusion, one signal captures most of the underlying variability of the low-frequency components of motor unit discharge rates and explains large part of the fluctuations in the motor output during isometric contractions.

Visuo-manual tracking: does intermittent control with aperiodic sampling explain linear power and non-linear remnant without sensorimotor noise?

Science.gov (United States)

Gollee, Henrik; Gawthrop, Peter J; Lakie, Martin; Loram, Ian D

2017-11-01

A human controlling an external system is described most easily and conventionally as linearly and continuously translating sensory input to motor output, with the inevitable output remnant, non-linearly related to the input, attributed to sensorimotor noise. Recent experiments show sustained manual tracking involves repeated refractoriness (insensitivity to sensory information for a certain duration), with the temporary 200-500 ms periods of irresponsiveness to sensory input making the control process intrinsically non-linear. This evidence calls for re-examination of the extent to which random sensorimotor noise is required to explain the non-linear remnant. This investigation of manual tracking shows how the full motor output (linear component and remnant) can be explained mechanistically by aperiodic sampling triggered by prediction error thresholds. Whereas broadband physiological noise is general to all processes, aperiodic sampling is associated with sensorimotor decision making within specific frontal, striatal and parietal networks; we conclude that manual tracking utilises such slow serial decision making pathways up to several times per second. The human operator is described adequately by linear translation of sensory input to motor output. Motor output also always includes a non-linear remnant resulting from random sensorimotor noise from multiple sources, and non-linear input transformations, for example thresholds or refractory periods. Recent evidence showed that manual tracking incurs substantial, serial, refractoriness (insensitivity to sensory information of 350 and 550 ms for 1st and 2nd order systems respectively). Our two questions are: (i) What are the comparative merits of explaining the non-linear remnant using noise or non-linear transformations? (ii) Can non-linear transformations represent serial motor decision making within the sensorimotor feedback loop intrinsic to tracking? Twelve participants (instructed to act in three prescribed

Ensemble Linear Neighborhood Propagation for Predicting Subchloroplast Localization of Multi-Location Proteins.

Science.gov (United States)

Wan, Shibiao; Mak, Man-Wai; Kung, Sun-Yuan

2016-12-02

In the postgenomic era, the number of unreviewed protein sequences is remarkably larger and grows tremendously faster than that of reviewed ones. However, existing methods for protein subchloroplast localization often ignore the information from these unlabeled proteins. This paper proposes a multi-label predictor based on ensemble linear neighborhood propagation (LNP), namely, LNP-Chlo, which leverages hybrid sequence-based feature information from both labeled and unlabeled proteins for predicting localization of both single- and multi-label chloroplast proteins. Experimental results on a stringent benchmark dataset and a novel independent dataset suggest that LNP-Chlo performs at least 6% (absolute) better than state-of-the-art predictors. This paper also demonstrates that ensemble LNP significantly outperforms LNP based on individual features. For readers' convenience, the online Web server LNP-Chlo is freely available at http://bioinfo.eie.polyu.edu.hk/LNPChloServer/ .

The Epstein-Barr virus nuclear antigen-6 protein co-localizes with EBNA-3 and survival of motor neurons protein

International Nuclear Information System (INIS)

Krauer, Kenia G.; Buck, Marion; Belzer, Deanna K.; Flanagan, James; Chojnowski, Grace M.; Sculley, Tom B.

2004-01-01

The Epstein-Barr virus nuclear antigen (EBNA)-6 protein is essential for Epstein-Barr virus (EBV)-induced immortalization of primary human B-lymphocytes in vitro. In this study, fusion proteins of EBNA-6 with green fluorescent protein (GFP) have been used to characterize its nuclear localization and organization within the nucleus. EBNA-6 associates with nuclear structures and in immunofluorescence demonstrate a punctate staining pattern. Herein, we show that the association of EBNA-6 with these nuclear structures was maintained throughout the cell cycle and with the use of GFP-E6 deletion mutants, that the region amino acids 733-808 of EBNA-6 contains a domain that can influence the association of EBNA-6 with these nuclear structures. Co-immunofluorescence and confocal analyses demonstrated that EBNA-6 and EBNA-3 co-localize in the nucleus of cells. Expression of EBNA-6, but not EBNA-3, caused a redistribution of nuclear survival of motor neurons protein (SMN) to the EBNA-6 containing nuclear structures resulting in co-localization of SMN with EBNA-6

Imparting Motion to a Test Object Such as a Motor Vehicle in a Controlled Fashion

Science.gov (United States)

Southward, Stephen C. (Inventor); Reubush, Chandler (Inventor); Pittman, Bryan (Inventor); Roehrig, Kurt (Inventor); Gerard, Doug (Inventor)

2014-01-01

An apparatus imparts motion to a test object such as a motor vehicle in a controlled fashion. A base has mounted on it a linear electromagnetic motor having a first end and a second end, the first end being connected to the base. A pneumatic cylinder and piston combination have a first end and a second end, the first end connected to the base so that the pneumatic cylinder and piston combination is generally parallel with the linear electromagnetic motor. The second ends of the linear electromagnetic motor and pneumatic cylinder and piston combination being commonly linked to a mount for the test object. A control system for the linear electromagnetic motor and pneumatic cylinder and piston combination drives the pneumatic cylinder and piston combination to support a substantial static load of the test object and the linear electromagnetic motor to impart controlled motion to the test object.

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

Science.gov (United States)

Scekic-Zahirovic, Jelena; Sendscheid, Oliver; El Oussini, Hajer; Jambeau, Mélanie; Sun, Ying; Mersmann, Sina; Wagner, Marina; Dieterlé, Stéphane; Sinniger, Jérome; Dirrig-Grosch, Sylvie; Drenner, Kevin; Birling, Marie-Christine; Qiu, Jinsong; Zhou, Yu; Li, Hairi; Fu, Xiang-Dong; Rouaux, Caroline; Shelkovnikova, Tatyana; Witting, Anke; Ludolph, Albert C; Kiefer, Friedemann; Storkebaum, Erik; Lagier-Tourenne, Clotilde; Dupuis, Luc

2016-05-17

FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of both lead to neurodegeneration remains elusive. To address this question, we generated knockin mice expressing mislocalized cytoplasmic FUS and complete FUS knockout mice. Both mouse models display similar perinatal lethality with respiratory insufficiency, reduced body weight and length, and largely similar alterations in gene expression and mRNA splicing patterns, indicating that mislocalized FUS results in loss of its normal function. However, FUS knockin mice, but not FUS knockout mice, display reduced motor neuron numbers at birth, associated with enhanced motor neuron apoptosis, which can be rescued by cell-specific CRE-mediated expression of wild-type FUS within motor neurons. Together, our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of function, but also triggers motor neuron death through a toxic gain of function within motor neurons. © 2016 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

Linear and nonlinear auditory response properties of interneurons in a high-order avian vocal motor nucleus during wakefulness.

Science.gov (United States)

Raksin, Jonathan N; Glaze, Christopher M; Smith, Sarah; Schmidt, Marc F

2012-04-01

Motor-related forebrain areas in higher vertebrates also show responses to passively presented sensory stimuli. However, sensory tuning properties in these areas, especially during wakefulness, and their relation to perception, are poorly understood. In the avian song system, HVC (proper name) is a vocal-motor structure with auditory responses well defined under anesthesia but poorly characterized during wakefulness. We used a large set of stimuli including the bird's own song (BOS) and many conspecific songs (CON) to characterize auditory tuning properties in putative interneurons (HVC(IN)) during wakefulness. Our findings suggest that HVC contains a diversity of responses that vary in overall excitability to auditory stimuli, as well as bias in spike rate increases to BOS over CON. We used statistical tests to classify cells in order to further probe auditory responses, yielding one-third of neurons that were either unresponsive or suppressed and two-thirds with excitatory responses to one or more stimuli. A subset of excitatory neurons were tuned exclusively to BOS and showed very low linearity as measured by spectrotemporal receptive field analysis (STRF). The remaining excitatory neurons responded well to CON stimuli, although many cells still expressed a bias toward BOS. These findings suggest the concurrent presence of a nonlinear and a linear component to responses in HVC, even within the same neuron. These characteristics are consistent with perceptual deficits in distinguishing BOS from CON stimuli following lesions of HVC and other song nuclei and suggest mirror neuronlike qualities in which "self" (here BOS) is used as a referent to judge "other" (here CON).

Motor Skill Competence and Perceived Motor Competence: Which Best Predicts Physical Activity among Girls?

Science.gov (United States)

Khodaverdi, Zeinab; Bahram, Abbas; Khalaji, Hassan; Kazemnejad, Anoshirvan

2013-10-01

The main purpose of this study was to determine which correlate, perceived motor competence or motor skill competence, best predicts girls' physical activity behavior. A sample of 352 girls (mean age=8.7, SD=0.3 yr) participated in this study. To assess motor skill competence and perceived motor competence, each child completed the Test of Gross Motor Development-2 and Physical Ability sub-scale of Marsh's Self-Description Questionnaire. Children's physical activity was assessed by the Physical Activity Questionnaire for Older Children. Multiple linear regression model was used to determine whether perceived motor competence or motor skill competence best predicts moderate-to-vigorous self-report physical activity. Multiple regression analysis indicated that motor skill competence and perceived motor competence predicted 21% variance in physical activity (R(2)=0.21, F=48.9, P=0.001), and motor skill competence (R(2)=0.15, ᵝ=0.33, P= 0.001) resulted in more variance than perceived motor competence (R(2)=0.06, ᵝ=0.25, P=0.001) in physical activity. Results revealed motor skill competence had more influence in comparison with perceived motor competence on physical activity level. We suggest interventional programs based on motor skill competence and perceived motor competence should be administered or implemented to promote physical activity in young girls.

Robot Arm with Tendon Connector Plate and Linear Actuator

Science.gov (United States)

Ihrke, Chris A. (Inventor); Diftler, Myron A. (Inventor); Bridgwater, Lyndon (Inventor); Nguyen, Vienny (Inventor); Millerman, Alexander (Inventor)

2014-01-01

A robotic system includes a tendon-driven end effector, a linear actuator, a flexible tendon, and a plate assembly. The linear actuator assembly has a servo motor and a drive mechanism, the latter of which translates linearly with respect to a drive axis of the servo motor in response to output torque from the servo motor. The tendon connects to the end effector and drive mechanism. The plate assembly is disposed between the linear actuator assembly and the tendon-driven end effector and includes first and second plates. The first plate has a first side that defines a boss with a center opening. The second plate defines an accurate through-slot having tendon guide channels. The first plate defines a through passage for the tendon between the center opening and a second side of the first plate. A looped end of the flexible tendon is received within the tendon guide channels.

Performance test of 100 W linear compressor

Energy Technology Data Exchange (ETDEWEB)

Ko, J; Ko, D. Y.; Park, S. J.; Kim, H. B.; Hong, Y. J.; Yeom, H. K. [Korea Institute of Machinery and Materials, Daejeon(Korea, Republic of)

2013-09-15

In this paper, we present test results of developed 100 W class linear compressor for Stirling-type pulse tube refrigerator. The fabricated linear compressor has dual-opposed configuration, free piston and moving magnet type linear motor. Power transfer, efficiency and required pressure waveform are predicted with designed and measured specifications. In experiments, room temperature test with flow impedance is conducted to evaluate performance of developed linear compressor. Flow impedance is loaded to compressor with metering valve for flow resistance, inertance tube for flow inertance and buffer volumes for flow compliance. Several operating parameters such as input voltage, current, piston displacement and pressure wave are measured for various operating frequency and fixed input current level. Behaviors of dynamics and performance of linear compressor as varying flow impedance are discussed with measured experimental results. The developed linear compressor shows 124 W of input power, 86 % of motor efficiency and 60 % of compressor efficiency at its resonant operating condition.

Evaluation of synthetic linear motor-molecule actuation energetics

OpenAIRE

Brough, Branden; Northrop, Brian H.; Schmidt, Jacob J.; Tseng, Hsian-Rong; Houk, Kendall N.; Stoddart, J. Fraser; Ho, Chih-Ming

2006-01-01

By applying atomic force microscope (AFM)-based force spectroscopy together with computational modeling in the form of molecular force-field simulations, we have determined quantitatively the actuation energetics of a synthetic motor-molecule. This multidisciplinary approach was performed on specifically designed, bistable, redox-controllable [2]rotaxanes to probe the steric and electrostatic interactions that dictate their mechanical switching at the single-molecule level. The fusion of expe...

HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.

Science.gov (United States)

Hao le, Thi; Duy, Phan Q; An, Min; Talbot, Jared; Iyer, Chitra C; Wolman, Marc; Beattie, Christine E

2017-11-29

Motoneurons establish a critical link between the CNS and muscles. If motoneurons do not develop correctly, they cannot form the required connections, resulting in movement defects or paralysis. Compromised development can also lead to degeneration because the motoneuron is not set up to function properly. Little is known, however, regarding the mechanisms that control vertebrate motoneuron development, particularly the later stages of axon branch and dendrite formation. The motoneuron disease spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein leading to defects in vertebrate motoneuron development and synapse formation. Here we show using zebrafish as a model system that SMN interacts with the RNA binding protein (RBP) HuD in motoneurons in vivo during formation of axonal branches and dendrites. To determine the function of HuD in motoneurons, we generated zebrafish HuD mutants and found that they exhibited decreased motor axon branches, dramatically fewer dendrites, and movement defects. These same phenotypes are present in animals expressing low levels of SMN, indicating that both proteins function in motoneuron development. HuD binds and transports mRNAs and one of its target mRNAs, Gap43 , is involved in axonal outgrowth. We found that Gap43 was decreased in both HuD and SMN mutants. Importantly, transgenic expression of HuD in motoneurons of SMN mutants rescued the motoneuron defects, the movement defects, and Gap43 mRNA levels. These data support that the interaction between SMN and HuD is critical for motoneuron development and point to a role for RBPs in SMA. SIGNIFICANCE STATEMENT In zebrafish models of the motoneuron disease spinal muscular atrophy (SMA), motor axons fail to form the normal extent of axonal branches and dendrites leading to decreased motor function. SMA is caused by low levels of the survival motor neuron (SMN) protein. We show in motoneurons in vivo that SMN interacts with the RNA binding

Parallel changes in cortical neuron biochemistry and motor function in protein-energy malnourished adult rats.

Science.gov (United States)

Alaverdashvili, Mariam; Hackett, Mark J; Caine, Sally; Paterson, Phyllis G

2017-04-01

While protein-energy malnutrition in the adult has been reported to induce motor abnormalities and exaggerate motor deficits caused by stroke, it is not known if alterations in mature cortical neurons contribute to the functional deficits. Therefore, we explored if PEM in adult rats provoked changes in the biochemical profile of neurons in the forelimb and hindlimb regions of the motor cortex. Fourier transform infrared spectroscopic imaging using a synchrotron generated light source revealed for the first time altered lipid composition in neurons and subcellular domains (cytosol and nuclei) in a cortical layer and region-specific manner. This change measured by the area under the curve of the δ(CH 2 ) band may indicate modifications in membrane fluidity. These PEM-induced biochemical changes were associated with the development of abnormalities in forelimb use and posture. The findings of this study provide a mechanism by which PEM, if not treated, could exacerbate the course of various neurological disorders and diminish treatment efficacy. Copyright © 2017 Elsevier Inc. All rights reserved.

Dynamic modeling and simulation of an induction motor with adaptive backstepping design of an input-output feedback linearization controller in series hybrid electric vehicle

Directory of Open Access Journals (Sweden)

Jalalifar Mehran

2007-01-01

Full Text Available In this paper using adaptive backstepping approach an adaptive rotor flux observer which provides stator and rotor resistances estimation simultaneously for induction motor used in series hybrid electric vehicle is proposed. The controller of induction motor (IM is designed based on input-output feedback linearization technique. Combining this controller with adaptive backstepping observer the system is robust against rotor and stator resistances uncertainties. In additional, mechanical components of a hybrid electric vehicle are called from the Advanced Vehicle Simulator Software Library and then linked with the electric motor. Finally, a typical series hybrid electric vehicle is modeled and investigated. Various tests, such as acceleration traversing ramp, and fuel consumption and emission are performed on the proposed model of a series hybrid vehicle. Computer simulation results obtained, confirm the validity and performance of the proposed IM control approach using for series hybrid electric vehicle.

The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein.

Science.gov (United States)

Tseng, Yu-Ting; Jong, Yuh-Jyh; Liang, Wei-Fang; Chang, Fang-Rong; Lo, Yi-Ching

2017-10-15

Deficiency of survival motor neuron (SMN) protein, which is encoded by the SMN1 and SMN2 genes, induces widespread splicing defects mainly in spinal motor neurons, and leads to spinal muscular atrophy (SMA). Currently, there is no effective treatment for SMA. Liuwei dihuang (LWDH), a traditional Chinese herbal formula, possesses multiple therapeutic benefits against various diseases via modulation of the nervous, immune and endocrine systems. Previously, we demonstrated water extract of LWDH (LWDH-WE) protects dopaminergic neurons and improves motor activity in models of Parkinson's disease. This study aimed to investigate the potential protection of LWDH-WE on SMN deficiency-induced neurodegeneration and muscle weakness. The effects of LWDH-WE on SMN deficiency-induced neurotoxicity and muscle atrophy were examined by using SMN-deficient NSC34 motor neuron-like cells and SMA-like mice, respectively. Inducible SMN-knockdown NSC34 motor neuron-like cells were used to mimic SMN-deficient condition. Doxycycline (1 µg/ml) was used to induce SMN deficiency in stable NSC34 cell line carrying SMN-specific shRNA. SMAΔ7 mice were used as a severe type of SMA mouse model. Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Apoptotic cells and neurite length were observed by inverted microscope. Protein expressions were examined by western blots. Muscle strength of animals was evaluated by hind-limb suspension test. LWDH-WE significantly increased SMN protein level, mitochondrial membrane potential and cell viability of SMN-deficient NSC34 cells. LWDH-WE attenuated SMN deficiency-induced down-regulation of B-cell lymphoma-2 (Bcl-2) and up-regulation of cytosolic cytochrome c and cleaved caspase-3. Moreover, LWDH-WE prevented SMN deficiency-induced inhibition of neurite outgrowth and activation of Ras homolog gene family, member A (RhoA)/ Rho-associated protein kinase (ROCK2)/ phospho

The operation of a single-sided linear induction motor with squirrel-cage and solid-steel reaction rails

Science.gov (United States)

Eastham, A. R.; Katz, R. M.

1980-09-01

Two test programs have been conducted to evaluate the performance of a single-sided linear induction motor with a squirrel-cage reaction rail and with a solid steel reaction rail. A 1.73-m-long six-pole stator interacted with the rails mounted on the rim of a 7.6-m-diam wheel. A 64-channel data acquisition system allowed tests to be performed over a wide range of operating conditions at speeds up to 20 m/sec. Typical test results which compare and contrast the mechanical, electrical and magnetic behavior of the SLIMs are presented. The test data are being used to assess the SLIM as an integrated suspension/propulsion system and for other transportation applications.

A review of linear compressors for refrigeration

OpenAIRE

Liang, Kun

2017-01-01

Linear compressor has no crank mechanism compared with conventional reciprocating compressor. This allows higher efficiency, oil-free operation, lower cost and smaller size when linear compressors are used for vapour compression refrigeration (VCR) system. Typically, a linear compressor consists of a linear motor (connected to a piston) and suspension springs, operated at resonant frequency. This paper presents a review of linear compressors for refrigeration system. Different designs and mod...

Protective effect of parvalbumin on excitotoxic motor neuron death

DEFF Research Database (Denmark)

Van den Bosch, L.; Schwaller, B.; Vleminckx, V.

2002-01-01

Amyotrophic lateral sclerosis, ALS, AMPA receptor, calcium-binding proteins, calcium buffering, excitotoxity, kainic acid, motor neuron, parvalbumin......Amyotrophic lateral sclerosis, ALS, AMPA receptor, calcium-binding proteins, calcium buffering, excitotoxity, kainic acid, motor neuron, parvalbumin...

Prediction of protein interaction hot spots using rough set-based multiple criteria linear programming.

Science.gov (United States)

Chen, Ruoying; Zhang, Zhiwang; Wu, Di; Zhang, Peng; Zhang, Xinyang; Wang, Yong; Shi, Yong

2011-01-21

Protein-protein interactions are fundamentally important in many biological processes and it is in pressing need to understand the principles of protein-protein interactions. Mutagenesis studies have found that only a small fraction of surface residues, known as hot spots, are responsible for the physical binding in protein complexes. However, revealing hot spots by mutagenesis experiments are usually time consuming and expensive. In order to complement the experimental efforts, we propose a new computational approach in this paper to predict hot spots. Our method, Rough Set-based Multiple Criteria Linear Programming (RS-MCLP), integrates rough sets theory and multiple criteria linear programming to choose dominant features and computationally predict hot spots. Our approach is benchmarked by a dataset of 904 alanine-mutated residues and the results show that our RS-MCLP method performs better than other methods, e.g., MCLP, Decision Tree, Bayes Net, and the existing HotSprint database. In addition, we reveal several biological insights based on our analysis. We find that four features (the change of accessible surface area, percentage of the change of accessible surface area, size of a residue, and atomic contacts) are critical in predicting hot spots. Furthermore, we find that three residues (Tyr, Trp, and Phe) are abundant in hot spots through analyzing the distribution of amino acids. Copyright © 2010 Elsevier Ltd. All rights reserved.

Investigation of New Morpholino Oligomers to Increase Survival Motor Neuron Protein Levels in Spinal Muscular Atrophy.

Science.gov (United States)

Ramirez, Agnese; Crisafulli, Sebastiano G; Rizzuti, Mafalda; Bresolin, Nereo; Comi, Giacomo P; Corti, Stefania; Nizzardo, Monica

2018-01-06

Spinal muscular atrophy (SMA) is an autosomal-recessive childhood motor neuron disease and the main genetic cause of infant mortality. SMA is caused by deletions or mutations in the survival motor neuron 1 ( SMN1 ) gene, which results in SMN protein deficiency. Only one approved drug has recently become available and allows for the correction of aberrant splicing of the paralogous SMN2 gene by antisense oligonucleotides (ASOs), leading to production of full-length SMN protein. We have already demonstrated that a sequence of an ASO variant, Morpholino (MO), is particularly suitable because of its safety and efficacy profile and is both able to increase SMN levels and rescue the murine SMA phenotype. Here, we optimized this strategy by testing the efficacy of four new MO sequences targeting SMN2 . Two out of the four new MO sequences showed better efficacy in terms of SMN protein production both in SMA induced pluripotent stem cells (iPSCs) and SMAΔ7 mice. Further, the effect was enhanced when different MO sequences were administered in combination. Our data provide an important insight for MO-based treatment for SMA. Optimization of the target sequence and validation of a treatment based on a combination of different MO sequences could support further pre-clinical studies and the progression toward future clinical trials.

Role of heat shock protein Hsp25 in the response of the orofacial nuclei motor system to physiological stress

Science.gov (United States)

Murashov, A. K.; Talebian, S.; Wolgemuth, D. J.

1998-01-01

Although expression of the small heat shock protein family member Hsp25 has been previously observed in the central nervous system (CNS), both constitutively and upon induction, its function in the CNS remains far from clear. In the present study we have characterized the spatial pattern of expression of Hsp25 in the normal adult mouse brain as well as the changes in expression patterns induced by subjecting mice to experimental hyperthermia or hypoxia. Immunohistochemical analysis revealed a surprisingly restricted pattern of constitutive expression of Hsp25 in the brain, limited to the facial, trigeminal, ambiguus, hypoglossal and vagal motor nuclei of the brainstem. After hyperthermia or hypoxia treatment, significant increases in the levels of Hsp25 were observed in these same areas and also in fibers of the facial and trigeminal nerve tracts. Immunoblot analysis of protein lysates from brainstem also showed the same pattern of induction of Hsp25. Surprisingly, no other area in the brain showed expression of Hsp25, in either control or stressed animals. The highly restricted expression of Hsp25 implies that this protein may have a specific physiological role in the orofacial motor nuclei, which govern precise coordination between muscles of mastication and the pharynx, larynx, and face. Its rapid induction after stress further suggests that Hsp25 may serve as a specific molecular chaperone in the lower cholinergic motor neurons and along their fibers under conditions of stress or injury. Copyright 1998 Elsevier Science B.V.

Compression of the DNA substrate by a viral packaging motor is supported by removal of intercalating dye during translocation.

Science.gov (United States)

Dixit, Aparna Banerjee; Ray, Krishanu; Black, Lindsay W

2012-12-11

Viral genome packaging into capsids is powered by high-force-generating motor proteins. In the presence of all packaging components, ATP-powered translocation in vitro expels all detectable tightly bound YOYO-1 dye from packaged short dsDNA substrates and removes all aminoacridine dye from packaged genomic DNA in vivo. In contrast, in the absence of packaging, the purified T4 packaging ATPase alone can only remove up to ∼1/3 of DNA-bound intercalating YOYO-1 dye molecules in the presence of ATP or ATP-γ-S. In sufficient concentration, intercalating dyes arrest packaging, but rare terminase mutations confer resistance. These distant mutations are highly interdependent in acquiring function and resistance and likely mark motor contact points with the translocating DNA. In stalled Y-DNAs, FRET has shown a decrease in distance from the phage T4 terminase C terminus to portal consistent with a linear motor, and in the Y-stem DNA compression between closely positioned dye pairs. Taken together with prior FRET studies of conformational changes in stalled Y-DNAs, removal of intercalating compounds by the packaging motor demonstrates conformational change in DNA during normal translocation at low packaging resistance and supports a proposed linear "DNA crunching" or torsional compression motor mechanism involving a transient grip-and-release structural change in B form DNA.

Motor Skills Training Improves Sensorimotor Dysfunction and Increases Microtubule-Associated Protein 2 mRNA Expression in Rats with Intracerebral Hemorrhage.

Science.gov (United States)

Tamakoshi, Keigo; Kawanaka, Kentaro; Onishi, Hideaki; Takamatsu, Yasuyuki; Ishida, Kazuto

2016-08-01

In this study, we examined the effects of motor skills training on the sensorimotor function and the expression of genes associated with synaptic plasticity after intracerebral hemorrhage (ICH) in rats. Male Wistar rats were subjected to ICH or sham operation. ICH was caused by the injection of collagenase into the left striatum. Rats were randomly assigned to no training, acrobatic training, and sham groups. The acrobatic group performed 5 types of acrobatic tasks from 4 to 28 days after surgery. The forelimb sensorimotor function was evaluated over time using forepaw grasping, forelimb placing, and postural instability tests. At 14 and 29 days after the lesion, we analyzed the mRNA expression levels of microtubule-associated protein 2 (MAP2), brain-derived neurotrophic factor, and growth-associated protein 43 in the bilateral sensorimotor cortex (forelimb area) by real-time reverse transcription-polymerase chain reaction. Motor skills training in ICH rats improved the sensorimotor dysfunction significantly from the early phase. The mRNA expression level of MAP2 was upregulated in the ipsilesional sensorimotor cortex by motor skills training at 29 days after the lesion. Our results suggest that sensorimotor functional recovery following motor skills training after ICH is promoted by dendritic growth in the ipsilesional sensorimotor cortex. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Small-sized linear accelerator of 2.5 MeV electrons with a local radiation shield for custom examination of freight transported by motor transport

International Nuclear Information System (INIS)

Baklanov, A.V.; Gavrish, Yu.N.; Klinov, A.P.; Krest'yaninov, A.S.; Nikolaev, V.M.; Fomin, L.P.; Linkenbach, H.A.; Geus, G.; Knospel, W.

2001-01-01

A new development of a small-sized linear accelerator of 2.5 MeV electrons with a local radiation protection is described. The accelerator is intended for movable facilities of radiation custom of the freight transported by motor transport. Main constructive solutions, mass and dimension characteristics and results of preliminary tests of the accelerator parameters and characteristics of radiation protection are presented [ru

Nonlinear analysis of field distribution in electric motor with periodicity conditions

Energy Technology Data Exchange (ETDEWEB)

Stabrowski, M M; Sikora, J

1981-01-01

Numerical analysis of electromagnetic field distribution in linear motion tubular electric motor has been performed with the aid of finite element method. Two Fortran programmes for the solution of DBBF and BF large linear symmetric equation systems have been developed for purposes of this analysis. A new iterative algorithm, taking into account iron nonlinearity and periodicity conditions, has been introduced. Final results of the analysis in the form of induction diagrammes and motor driving force are directly useful for motor designers.

Spinal atypical protein kinase C activity is necessary to stabilize inactivity-induced phrenic motor facilitation

Science.gov (United States)

Strey, K.A.; Nichols, N.L.; Baertsch, N.A.; Broytman, O.; Baker-Herman, T.L.

2012-01-01

The neural network controlling breathing must establish rhythmic motor output at a level adequate to sustain life. Reduced respiratory neural activity elicits a novel form of plasticity in circuits driving the diaphragm known as inactivity-induced phrenic motor facilitation (iPMF), a rebound increase in phrenic inspiratory output observed once respiratory neural drive is restored. The mechanisms underlying iPMF are unknown. Here, we demonstrate in anesthetized rats that spinal mechanisms give rise to iPMF, and that iPMF consists of at least two mechanistically distinct phases: 1) an early, labile phase that requires atypical PKC (PKCζ and/or PKCΙ/λ) activity to transition to a 2) late, stable phase. Early (but not late) iPMF is associated with increased interactions between PKCζ/Ι and the scaffolding protein ZIP/p62 in spinal regions associated with the phrenic motor pool. Although PKCζ/Ι activity is necessary for iPMF, spinal aPKC activity is not necessary for phrenic long-term facilitation (pLTF) following acute intermittent hypoxia, an activity-independent form of spinal respiratory plasticity. Thus, while iPMF and pLTF both manifest as prolonged increases in phrenic burst amplitude, they arise from distinct spinal cellular pathways. Our data are consistent with the hypotheses that: 1) local mechanisms sense and respond to reduced respiratory-related activity in the phrenic motor pool, and 2) inactivity-induced increases in phrenic inspiratory output require local PKCζ/Ι activity to stabilize into a long-lasting iPMF. Although the physiological role of iPMF is unknown, we suspect that iPMF represents a compensatory mechanism, assuring adequate motor output in a physiological system where prolonged inactivity ends life. PMID:23152633

Perbedaan Asupan Energi, Protein, Zink, dan Perkembangan pada Balita Stunting dan non Stunting

OpenAIRE

Adani, Farahiyah Yusni; Nindya, Triska Susila

2017-01-01

 Background: Stunting is a nutritional problem caused by inadequate nutrition intake for  a long time and/or recurrent infectious diseases. The impacts of stunting are increase mortality,  morbidity,  health costs, decrease cognitive development, motor, and language development.There are nutrients that important to linear growth as energy, protein, and zinc. Objectives: The purpose of this study was to analyze the differences of intake of the energy, protein, Zinc, development in stunting and...

Optimized linear motor and digital PID controller setup used in Mössbauer spectrometer

Science.gov (United States)

Kohout, Pavel; Kouřil, Lukáš; Navařík, Jakub; Novák, Petr; Pechoušek, Jiří

2014-10-01

Optimization of a linear motor and digital PID controller setup used in a Mössbauer spectrometer is presented. Velocity driving system with a digital PID feedback subsystem was developed in the LabVIEW graphical environment and deployed on the sbRIO real-time hardware device (National Instruments). The most important data acquisition processes are performed as real-time deterministic tasks on an FPGA chip. Velocity transducer of a double loudspeaker type with a power amplifier circuit is driven by the system. Series of calibration measurements were proceeded to find the optimal setup of the P, I, D parameters together with velocity error signal analysis. The shape and given signal characteristics of the velocity error signal are analyzed in details. Remote applications for controlling and monitoring the PID system from computer or smart phone, respectively, were also developed. The best setup and P, I, D parameters were set and calibration spectrum of α-Fe sample with an average nonlinearity of the velocity scale below 0.08% was collected. Furthermore, the width of the spectral line below 0.30 mm/s was observed. Powerful and complex velocity driving system was designed.

Linear step drive

International Nuclear Information System (INIS)

Haniger, L.; Elger, R.; Kocandrle, L.; Zdebor, J.

1986-01-01

A linear step drive is described developed in Czechoslovak-Soviet cooperation and intended for driving WWER-1000 control rods. The functional principle is explained of the motor and the mechanical and electrical parts of the drive, power control, and the indicator of position are described. The motor has latches situated in the reactor at a distance of 3 m from magnetic armatures, it has a low structural height above the reactor cover, which suggests its suitability for seismic localities. Its magnetic circuits use counterpoles; the mechanical shocks at the completion of each step are damped using special design features. The position indicator is of a special design and evaluates motor position within ±1% of total travel. A drive diagram and the flow chart of both the control electronics and the position indicator are presented. (author) 4 figs

Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.

Directory of Open Access Journals (Sweden)

Gareth W Morgan

2010-02-01

Full Text Available Vaccinia virus (VACV uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC, a subunit of the kinesin-1 motor that binds cargo. F12 and KLC share similar size, pI, hydropathy and cargo-binding tetratricopeptide repeats (TPRs. Moreover, molecular modeling of F12 TPRs upon the crystal structure of KLC2 TPRs showed a striking conservation of structure. We also identified multiple TPRs in VACV proteins E2 and A36. Data presented demonstrate that F12 is critical for recruitment of kinesin-1 to virions and that a conserved tryptophan and aspartic acid (WD motif, which is conserved in the kinesin-1-binding sequence (KBS of the neuronal protein calsyntenin/alcadein and several other cellular kinesin-1 binding proteins, is essential for kinesin-1 recruitment and virion transport. In contrast, mutation of WD motifs in protein A36 revealed they were not required for kinesin-1 recruitment or IEV transport. This report of a viral KLC-like protein containing a KBS that is conserved in several cellular proteins advances our understanding of how VACV recruits the kinesin motor to virions, and exemplifies how viruses use molecular mimicry of cellular components to their advantage.

Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells

Directory of Open Access Journals (Sweden)

Sota Iwatani

2017-09-01

Full Text Available BackgroundSpinal muscular atrophy (SMA is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expressed and functionally linked to general RNA metabolism pathway, fibroblasts (FBs are most widely used for the assessment of SMN expression in SMA patients but usually isolated from skin biopsy samples after the onset of overt symptoms. Although recent translational studies of SMN-targeted therapies have revealed the very limited time window for effective SMA therapies during perinatal period, the exact time point when SMN shortage became evident is unknown in human samples. In this study, we analyzed SMN mRNA and protein expression during perinatal period by using umbilical cord-derived mesenchymal stem cells (UC-MSCs obtained from preterm and term infants.MethodsUC-MSCs were isolated from 16 control infants delivered at 22–40 weeks of gestation and SMA fetus aborted at 19 weeks of gestation (UC-MSC-Control and UC-MSC-SMA. FBs were isolated from control volunteer and SMA patient (FB-Control and FB-SMA. SMN mRNA and protein expression in UC-MSCs and FBs was determined by RT-qPCR and Western blot.ResultsUC-MSC-Control and UC-MSC-SMA expressed the comparable level of MSC markers on their cell surface and were able to differentiate into adipocytes, osteocytes, and chondrocytes. At steady state, SMN mRNA and protein expression was decreased in UC-MSC-SMA compared to UC-MSC-Control, as observed in FB-SMA and FB-Control. In response to histone deacetylase inhibitor valproic acid, SMN mRNA and protein expression in UC-MSC-SMA and FB-SMA was increased. During perinatal development from 22 to 40 weeks of gestation, SMN mRNA and protein expression in UC-MSC-Control was positively correlated with gestational age.ConclusionUC-MSCs isolated from 17 fetus/infant of 19–40 weeks of gestation

Advanced AC Motor Control

Energy Technology Data Exchange (ETDEWEB)

Kazmierkowski, M.P. [Institute of Control and Industrial Electronics, Warsaw University of Technology, Warszawa (Poland)

1997-12-31

In this paper a review of control methods for high performance PWM inverter-fed induction motor drives is presented. Starting from the description of an induction motor by the help of the space vectors, three basic control strategic are discussed. As first, the most popular Field Oriented Control (FOC) is described. Secondly, the Direct Torque and Flux vector Control (DTFC) method, which - in contrast to FOC - depart from idea of coordinate transformation and analogy with DC motor, is briefly characterized. The last group is based on Feedback Linearization Control (FLC) and can be easy combined with sliding mode control. The simulation and experimental oscillograms that illustrate the performance of the discussed control strategies are shown. (orig.) 35 refs.

Balancing Vibrations at Harmonic Frequencies by Injecting Harmonic Balancing Signals into the Armature of a Linear Motor/Alternator Coupled to a Stirling Machine

Science.gov (United States)

Holliday, Ezekiel S. (Inventor)

2014-01-01

Vibrations at harmonic frequencies are reduced by injecting harmonic balancing signals into the armature of a linear motor/alternator coupled to a Stirling machine. The vibrations are sensed to provide a signal representing the mechanical vibrations. A harmonic balancing signal is generated for selected harmonics of the operating frequency by processing the sensed vibration signal with adaptive filter algorithms of adaptive filters for each harmonic. Reference inputs for each harmonic are applied to the adaptive filter algorithms at the frequency of the selected harmonic. The harmonic balancing signals for all of the harmonics are summed with a principal control signal. The harmonic balancing signals modify the principal electrical drive voltage and drive the motor/alternator with a drive voltage component in opposition to the vibration at each harmonic.

A classical Master equation approach to modeling an artificial protein motor

International Nuclear Information System (INIS)

Kuwada, Nathan J.; Blab, Gerhard A.; Linke, Heiner

2010-01-01

Inspired by biomolecular motors, as well as by theoretical concepts for chemically driven nanomotors, there is significant interest in constructing artificial molecular motors. One driving force is the opportunity to create well-controlled model systems that are simple enough to be modeled in detail. A remaining challenge is the fact that such models need to take into account processes on many different time scales. Here we describe use of a classical Master equation approach, integrated with input from Langevin and molecular dynamics modeling, to stochastically model an existing artificial molecular motor concept, the Tumbleweed, across many time scales. This enables us to study how interdependencies between motor processes, such as center-of-mass diffusion and track binding/unbinding, affect motor performance. Results from our model help guide the experimental realization of the proposed motor, and potentially lead to insights that apply to a wider class of molecular motors.

Gross motor development in full-term Greek infants assessed by the Alberta Infant Motor Scale: reference values and socioeconomic impact.

Science.gov (United States)

Syrengelas, Dimitrios; Kalampoki, Vassiliki; Kleisiouni, Paraskevi; Konstantinou, Dimitrios; Siahanidou, Tania

2014-07-01

The aims of this study were to investigate gross motor development in Greek infants and establish AIMS percentile curves and to examine possible association of AIMS scores with socioeconomic parameters. Mean AIMS scores of 1068 healthy Greek full-term infants were compared at monthly age level with the respective mean scores of the Canadian normative sample. In a subgroup of 345 study participants, parents provided, via interview, information about family socioeconomic status. Multiple linear regression analysis was performed to evaluate the relationship of infant motor development with socioeconomic parameters. Mean AIMS scores did not differ significantly between Greek and Canadian infants in any of the 19 monthly levels of age. In multiple linear regression analysis, the educational level of the mother and also whether the infant was being raised by grandparents/babysitter were significantly associated with gross motor development (p=0.02 and psocioeconomic factors are associated with the infants' motor development. Copyright © 2014 Elsevier Ltd. All rights reserved.

Nonlinear Control of Induction Motors: A Performance Study

DEFF Research Database (Denmark)

Rasmussen, Henrik; Vadstrup, P.; Børsting, H.

1998-01-01

A novel approach to control of induction motors based on nonlinear state feedback has previously been presented by the authors. The resulting scheme gives a linearized input-output decoupling of the torque and the amplitude of the field. The proposed approach is used to design controllers for the...... for the field amplitude and the motor torque. The method is compared with the traditional Rotor Field Oriented Control method as regards variations in rotor resistance an magnetizing inductance......A novel approach to control of induction motors based on nonlinear state feedback has previously been presented by the authors. The resulting scheme gives a linearized input-output decoupling of the torque and the amplitude of the field. The proposed approach is used to design controllers...

Gap junctions and motor behavior

DEFF Research Database (Denmark)

Kiehn, Ole; Tresch, Matthew C.

2002-01-01

The production of any motor behavior requires coordinated activity in motor neurons and premotor networks. In vertebrates, this coordination is often assumed to take place through chemical synapses. Here we review recent data suggesting that electrical gap-junction coupling plays an important role...... in coordinating and generating motor outputs in embryonic and early postnatal life. Considering the recent demonstration of a prevalent expression of gap-junction proteins and gap-junction structures in the adult mammalian spinal cord, we suggest that neuronal gap-junction coupling might also contribute...... to the production of motor behavior in adult mammals....

The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans.

Science.gov (United States)

Florica, Roxana Oriana; Hipolito, Victoria; Bautista, Stephen; Anvari, Homa; Rapp, Chloe; El-Rass, Suzan; Asgharian, Alimohammad; Antonescu, Costin N; Killeen, Marie T

2017-10-01

The axons of the DA and DB classes of motor neurons fail to reach the dorsal cord in the absence of the guidance cue UNC-6/Netrin or its receptor UNC-5 in C. elegans. However, the axonal processes usually exit their cell bodies in the ventral cord in the absence of both molecules. Strains lacking functional versions of UNC-6 or UNC-5 have a low level of DA and DB motor neuron axon outgrowth defects. We found that mutations in the genes for all six of the ENU-3 proteins function to enhance the outgrowth defects of the DA and DB axons in strains lacking either UNC-6 or UNC-5. A mutation in the gene for the MIG-14/Wntless protein also enhances defects in a strain lacking either UNC-5 or UNC-6, suggesting that the ENU-3 and Wnt pathways function parallel to the Netrin pathway in directing motor neuron axon outgrowth. Our evidence suggests that the ENU-3 proteins are novel members of the Wnt pathway in nematodes. Five of the six members of the ENU-3 family are predicted to be single-pass trans-membrane proteins. The expression pattern of ENU-3.1 was consistent with plasma membrane localization. One family member, ENU-3.6, lacks the predicted signal peptide and the membrane-spanning domain. In HeLa cells ENU-3.6 had a cytoplasmic localization and caused actin dependent processes to appear. We conclude that the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway. Copyright © 2017 Elsevier Inc. All rights reserved.

Non-linear Relationship between BOLD Activation and Amplitude of Beta Oscillations in the Supplementary Motor Area during Rhythmic Finger Tapping and Internal Timing

Science.gov (United States)

Gompf, Florian; Pflug, Anja; Laufs, Helmut; Kell, Christian A.

2017-01-01

Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region. PMID:29249950

Non-linear Relationship between BOLD Activation and Amplitude of Beta Oscillations in the Supplementary Motor Area during Rhythmic Finger Tapping and Internal Timing.

Science.gov (United States)

Gompf, Florian; Pflug, Anja; Laufs, Helmut; Kell, Christian A

2017-01-01

Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region.

Direct torque control with feedback linearization for induction motor drives

DEFF Research Database (Denmark)

Lascu, Cristian; Jafarzadeh, Saeed; Fadali, Sami M.

2015-01-01

This paper describes a Direct Torque Controlled (DTC) Induction Machine (IM) drive that employs feedback linearization and sliding-mode control. A feedback linearization approach is investigated, which yields a decoupled linear IM model with two state variables: torque and stator flux magnitude....... This intuitive linear model is used to implement a DTC type controller that preserves all DTC advantages and eliminates its main drawback, the flux and torque ripple. Robust, fast, and ripple-free control is achieved by using Variable Structure Control (VSC) with proportional control in the vicinity...... robust stability analysis are presented. The sliding controller is compared with a linear DTC scheme, and experimental results for a sensorless IM drive validate the proposed solution....

Protein-Energy Malnutrition Causes Deficits in Motor Function in Adult Male Rats.

Science.gov (United States)

Alaverdashvili, Mariam; Li, Xue; Paterson, Phyllis G

2015-11-01

Adult protein-energy malnutrition (PEM) often occurs in combination with neurological disorders affecting hand use and walking ability. The independent effects of PEM on motor function are not well characterized and may be obscured by these comorbidities. Our goal was to undertake a comprehensive evaluation of sensorimotor function with the onset and progression of PEM in an adult male rat model. In Expt. 1 and Expt. 2, male Sprague-Dawley rats (14-15 wk old) were assigned ad libitum access for 4 wk to normal-protein (NP) or low-protein (LP) diets containing 12.5% and 0.5% protein, respectively. Expt. 1 assessed muscle strength, balance, and skilled walking ability on days 2, 8, and 27 by bar-holding, cylinder, and horizontal ladder walking tasks, respectively. In addition to food intake and body weight, nutritional status was determined on days 3, 9, and 28 by serum acute-phase reactant and corticosterone concentrations and liver lipids. Expt. 2 addressed the effect of an LP diet on hindlimb muscle size. PEM evolved over time in rats consuming the LP diet. Total food intake decreased by 24% compared with the NP group. On day 28, body weight and serum albumin decreased by 31% and 26%, respectively, and serum α2-macroglobulin increased by 445% (P malnutrition. This model can be used in combination with disease models of sensorimotor deficits to examine the interactions between nutritional status, other treatments, and disease progression. © 2015 American Society for Nutrition.

A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.

Science.gov (United States)

Nicholson, Judith; Scherl, Alex; Way, Luke; Blackburn, Elizabeth A; Walkinshaw, Malcolm D; Ball, Kathryn L; Hupp, Ted R

2014-06-01

Linear motifs mediate protein-protein interactions (PPI) that allow expansion of a target protein interactome at a systems level. This study uses a proteomics approach and linear motif sub-stratifications to expand on PPIs of MDM2. MDM2 is a multi-functional protein with over one hundred known binding partners not stratified by hierarchy or function. A new linear motif based on a MDM2 interaction consensus is used to select novel MDM2 interactors based on Nutlin-3 responsiveness in a cell-based proteomics screen. MDM2 binds a subset of peptide motifs corresponding to real proteins with a range of allosteric responses to MDM2 ligands. We validate cyclophilin B as a novel protein with a consensus MDM2 binding motif that is stabilised by Nutlin-3 in vivo, thus identifying one of the few known interactors of MDM2 that is stabilised by Nutlin-3. These data invoke two modes of peptide binding at the MDM2 N-terminus that rely on a consensus core motif to control the equilibrium between MDM2 binding proteins. This approach stratifies MDM2 interacting proteins based on the linear motif feature and provides a new biomarker assay to define clinically relevant Nutlin-3 responsive MDM2 interactors. Copyright © 2014 Elsevier Inc. All rights reserved.

Design, analysis and fabrication of a linear permanent magnet ...

Indian Academy of Sciences (India)

MONOJIT SEAL

Linear permanent magnet synchronous machine; LPMSM—fabrication; design optimisation; finite-element ... induction motor (LIM) prototype was patented in 1890 [1]. Since then, linear ..... Also, for manual winding, more slot area is allotted to ...

An oral Na(V)1.8 blocker improves motor function in mice completely deficient of myelin protein P-0

DEFF Research Database (Denmark)

Rosberg, Mette R.; Alvarez Herrero, Susana; Krarup, Christian

2016-01-01

Mice deficient of myelin protein P0 are established models of demyelinating Charcot-Marie-Tooth (CMT) disease. Dysmyelination in these mice is associated with an ectopic expression of the sensory neuron specific sodium channel isoform NaV1.8 on motor axons. We reported that in P0+/−, a model of CMT......1B, the membrane dysfunction could be acutely improved by a novel oral NaV1.8 blocker referred to as Compound 31 (C31, Bioorg. Med. Chem. Lett. 2010, 20, 6812; AbbVie Inc.). The aim of this study was to investigate the extent to which C31 treatment could also improve the motor axon function in P0......-of-concept that treatment with oral subtype-selective NaV1.8 blockers could be used to improve the motor function in severe forms of demyelinating CMT....

Steady State Dynamic Operating Behavior of Universal Motor

Directory of Open Access Journals (Sweden)

Muhammad Khan Burdi

2015-01-01

Full Text Available A detailed investigation of the universal motor is developed and used for various dynamic steady state and transient operating conditions of loads. In the investigation, output torque, motor speed, input current, input/output power and efficiency are computed, compared and analyzed for different loads. While this paper discusses the steady-state behavior of the universal motor, another companion paper, ?Transient dynamic behavior of universal motor?, will discuss its transient behavior in detail. A non-linear generalized electric machine model of the motor is considered for the analysis. This study was essential to investigate effect of output load on input current, power, speed and efficiency of the motor during operations. Previously such investigation is not known

Design Analysis of Taper Width Variations in Magnetless Linear Machine for Traction Applications

Directory of Open Access Journals (Sweden)

Saadha Aminath

2018-01-01

Full Text Available Linear motors are being used in a different application with a huge popularity in the use of transport industry. With the invention of maglev trains and other high-speed trains, linear motors are being used for the translation and braking applications for these systems. However, a huge drawback of the linear motor design is the cogging force, low thrust values, and voltage ripples. This paper aims to study the force analysis with change in taper/teeth width of the motor stator and mover to understand the best teeth ratio to obtain a high flux density and a high thrust. The analysis is conducted through JMAG software and it is found that the optimum teeth ratio for both the stator and mover gives an increase of 94.4% increases compared to the 0.5mm stator and mover width.

Imparting motion to a test object such as a motor vehicle in a controlled fashion

OpenAIRE

2011-01-01

An apparatus imparts motion to a test object such as a motor vehicle in a controlled fashion. A base has mounted on it a linear electromagnetic motor having a first end and a second end, the first end being connected to the base. A pneumatic cylinder and piston combination have a first end and a second end, the first end connected to the base so that the pneumatic cylinder and piston combination is generally parallel with the linear electromagnetic motor. The second ends of the linear electro...

Protein fiber linear dichroism for structure determination and kinetics in a low-volume, low-wavelength couette flow cell

OpenAIRE

Dafforn, Tim; Rajendra, Jacindra; Halsall, David J.; Serpell, Louise C.; Rodger, Alison

2004-01-01

High-resolution structure determination of soluble globular proteins relies heavily on x-ray crystallography techniques. Such an approach is often ineffective for investigations into the structure of fibrous proteins as these proteins generally do not crystallize. Thus investigations into fibrous protein structure have relied on less direct methods such as x-ray fiber diffraction and circular dichroism. Ultraviolet linear dichroism has the potential to provide additional information on the st...

Development of Maglev and linear drive technology for transportation in Japan

Energy Technology Data Exchange (ETDEWEB)

Masada, Eisuke [Tokyo Univ. (Germany)

1996-12-31

In order to realise guided ground transportation systems with superspeed, better riding comforts and environmental effects two types of maglev transports, JR-Maglev and HSST have been developed since 20 years in Japan. JR-Maglev is bases on a electro-dynamic suspension system and driven by long-stator linear synchronous motors. HSST is an electromagnetic suspension system with short-stator linear induction motor. Both systems are presented. (HW)

Piezoelectric/magnetostrictive resonant inchworm motor

Science.gov (United States)

Miesner, John E.; Teter, Joseph P.

1994-05-01

Magnetostrictive and piezoelectric materials were used to create a linear motor operating on the inchworm principle. This motor operates at an electrical resonance, switching power internally between inductive and capacitive components. Magnetic coils surrounding the two Terfenol-D rods which drive the inchworm's center expanding element form the inductive component. Piezoelectric stacks that control the end clamping action are the capacitive components. The normal electrical phase relationship between these components provides natural drive timing for the inchworm. The motor direction can be easily reversed by changing the magnetic bias on the Terfenol. A prototype motor was built that achieved a stall load of 26 lb and no-load speed of 1 inch/sec vs the design of 30 lb and 1.3 inch/sec. A new type of power supply that switches power from a dc source was built for the motor. This power supply uses a small number of components to exactly supply the energy used in each inchworm cycle. It tracks the motor circuit resonance and is not affected by frequency shifts.

Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease.

Directory of Open Access Journals (Sweden)

Atsushi Umemura

Full Text Available C-reactive protein (CRP, a blood inflammatory biomarker, is associated with the development of Alzheimer disease. In animal models of Parkinson disease (PD, systemic inflammatory stimuli can promote neuroinflammation and accelerate dopaminergic neurodegeneration. However, the association between long-term systemic inflammations and neurodegeneration has not been assessed in PD patients.To investigate the longitudinal effects of baseline CRP concentrations on motor prognosis in PD.Retrospective analysis of 375 patients (mean age, 69.3 years; mean PD duration, 6.6 years. Plasma concentrations of high-sensitivity CRP were measured in the absence of infections, and the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III scores were measured at five follow-up intervals (Days 1-90, 91-270, 271-450, 451-630, and 631-900.Change of UPDRS-III scores from baseline to each of the five follow-up periods.Change in UPDRS-III scores was significantly greater in PD patients with CRP concentrations ≥0.7 mg/L than in those with CRP concentrations <0.7 mg/L, as determined by a generalized estimation equation model (P = 0.021 for the entire follow-up period and by a generalized regression model (P = 0.030 for the last follow-up interval (Days 631-900. The regression coefficients of baseline CRP for the two periods were 1.41 (95% confidence interval [CI] 0.21-2.61 and 2.62 (95% CI 0.25-4.98, respectively, after adjusting for sex, age, baseline UPDRS-III score, dementia, and incremental L-dopa equivalent dose.Baseline plasma CRP levels were associated with motor deterioration and predicted motor prognosis in patients with PD. These associations were independent of sex, age, PD severity, dementia, and anti-Parkinsonian agents, suggesting that subclinical systemic inflammations could accelerate neurodegeneration in PD.

Comparison of Thrust Characteristics in Pencil Sized Cylinder-type Linear Motors with Different Magnet Arrays(Asia-Pacific Symposium on Applied Electromagnetics and Mechanics (APSAEM08))

OpenAIRE

K., Nakaiwa; A., Yamada; K., Tashiro; H., Wakiwaka; Tamagawa-Seiki Co., Ltd; Shinshu University; Shinshu University; Shinshu University

2009-01-01

From a strong demand on the miniaturization of a chip mounter or a semiconductor device, the thrust improvement considering the magnets arrangement is studied. We accept a core stator with a Halbach type magnet array for a current linear motor. The thrust characteristics are compared with two kinds of mover, a NS magnet array and a Halbach magnet array.

The effect of electroacupuncture on proteomic changes in the motor cortex of 6-OHDA Parkinsonian rats.

Science.gov (United States)

Li, Min; Li, Lijuan; Wang, Ke; Su, Wenting; Jia, Jun; Wang, Xiaomin

2017-10-15

Electroacupuncture (EA) has been reported to alleviate motor deficits in Parkinson's disease (PD) patients, and PD animal models. However, the mechanisms by which EA improves motor function have not been investigated. We have employed a 6-hydroxydopamine (6-OHDA) unilateral injection induced PD model to investigate whether EA alters protein expression in the motor cortex. We found that 4weeks of EA treatment significantly improved spontaneous floor plane locomotion and rotarod performance. High-throughput proteomic analysis in the motor cortex was employed. The expression of 54 proteins were altered in the unlesioned motor cortex, and 102 protein expressions were altered in the lesioned motor cortex of 6-OHDA rats compared to sham rats. Compared to non-treatment PD control, EA treatment reversed 6 proteins in unlesioned and 19 proteins in lesioned motor cortex. The present study demonstrated that PD induces proteomic changes in the motor cortex, some of which are rescued by EA treatment. These targeted proteins were mainly involved in increasing autophagy, mRNA processing and ATP binding and maintaining the balance of neurotransmitters. Copyright © 2017 Elsevier B.V. All rights reserved.

Design elements and quantitative results of synchronous longstator linear motors for high-speed magnetic trains taking the TRANSRAPID test facility in Emsland as an example

Energy Technology Data Exchange (ETDEWEB)

Fuerst, R [Industrieanlagen-Betriebsgesellschaft mbH, Magnetbahn-Versuchsanlage, Lathen/Ems (Germany)

1996-12-31

In German high-speed magnetic train technology, iron-clad synchronous long-stator linear motors of levitation stator design are used to propel and brake the vehicles. This paper uses the propulsion design of the Transrapid test facility in Emsland (TVE) to illustrate in practical terms the dimensioning parameters for thrust calculations and their interdependencies. The paper is based on description conventions common for rotating electrical machines and rail technology. (orig.)

Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor Phenotype.

Science.gov (United States)

Ba, Fang; Obaid, Mona; Wieler, Marguerite; Camicioli, Richard; Martin, W R Wayne

2016-03-01

Parkinson disease (PD) presents with motor and non-motor symptoms (NMS). The NMS often precede the onset of motor symptoms, but may progress throughout the disease course. Tremor dominant, postural instability gait difficulty (PIGD), and indeterminate phenotypes can be distinguished using Unified PD Rating scales (UPDRS-III). We hypothesized that the PIGD phenotype would be more likely to develop NMS, and that the non-dopamine-responsive axial signs would correlate with NMS severity. We conducted a retrospective cross-sectional chart review to assess the relationship between NMS and PD motor phenotypes. PD patients were administered the NMS Questionnaire, the UPDRS-III, and the Mini-Mental State Examination score. The relationship between NMS burden and PD subtypes was examined using linear regression models. The prevalence of each NMS among difference PD motor subtypes was analyzed using chi-square test. PD patients with more advanced disease based on their UPDRS-III had higher NMS Questionnaire scores. The axial component of UPDRS-III correlated with higher NMS. There was no correlation between NMS and tremor scores. There was a significant correlation between PIGD score and higher NMS burden. PIGD group had higher prevalence in most NMS domains when compared with tremor dominant and indeterminate groups independent of disease duration and severity. NMS profile and severity vary according to motor phenotype. We conclude that in the PD population, patients with a PIGD phenotype who have more axial involvement, associated with advanced disease and poor motor response, have a higher risk for a higher NMS burden.

Experimental device for measuring the dynamic properties of diaphragm motors

Science.gov (United States)

Fojtášek, Kamil; Dvořák, Lukáš; Mejzlík, Jan

The subject of this paper is to design and description of the experimental device for the determination dynamic properties of diaphragm pneumatic motors. These motors are structurally quite different from conventional pneumatic linear cylinders. The working fluid is typically compressed air, the piston of motor is replaced by an elastic part and during the working cycle there is a contact of two elastic environments. In the manufacturers catalogs of these motors are not given any working characteristics. Description of the dynamic behavior of diaphragm motor will be used for verification of mathematical models.

Olfaction Is Related to Motor Function in Older Adults.

Science.gov (United States)

Tian, Qu; Resnick, Susan M; Studenski, Stephanie A

2017-08-01

Among older adults, both olfaction and motor function predict future cognitive decline and dementia, suggesting potential shared causal pathways. However, it is not known whether olfactory and motor function are independently related in late life. We assessed cross-sectional associations of olfaction with motor and cognitive function, using concurrent data on olfactory function, mobility, balance, fine motor function, manual dexterity, and cognition in 163 Baltimore Longitudinal Study of Aging participants aged 60 and older without common neurological diseases (n = 114 with available cognitive data). Using multiple linear regression, we adjusted for age, sex, race, smoking history, height, and weight for mobility and balance, and education for cognition. We used multiple linear regression to test whether olfaction-motor associations were independent of cognition and depressive symptoms. Olfactory scores were significantly associated with mobility (usual gait speed, rapid gait speed, 400-m walk time, and Health ABC Physical Performance Battery score), balance, fine motor function, and manual dexterity (all p function is associated with mobility, balance, fine motor function, and manual dexterity, and independent of cognitive function, with challenging upper and lower extremity motor function tasks. Longitudinal studies are needed to determine if olfactory performance predicts future mobility and functional decline. Published by Oxford University Press on behalf of The Gerontological Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Shape memory alloy based motor

Indian Academy of Sciences (India)

1989a,b) that SMA spring or strip generates force as a non-linear function of its deformed length. ... magnetic property, smooth, jerk free operation and insensitivity to space radiations namely, electrons, protons ..... will be 1 Amp DC. The motor ...

Bicaudal-D: Switching motors, cargo and direction

NARCIS (Netherlands)

G.D. Splinter (Daniël)

2008-01-01

textabstractScope of this thesis Transport of vesicles and organelles is an essential cellular process. Proteins like Rab GTPases, specialized adaptor proteins and motor proteins are involved in targeting and movement of cargos to their destination. This thesis describes the function of the

Coevolved Mutations Reveal Distinct Architectures for Two Core Proteins in the Bacterial Flagellar Motor.

Directory of Open Access Journals (Sweden)

Alessandro Pandini

Full Text Available Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC "torque" helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy reconstruction have implications for switching, but lack consensus on the relative locations of the FliG armadillo (ARM domains (amino-terminal (FliGN, middle (FliGM and FliGC as well as changes during chemotaxis. The generality of the Salmonella model is challenged by the variation in motor morphology and response between species. We studied coevolved residue mutations to determine the unifying elements of switch architecture. Residue interactions, measured by their coevolution, were formalized as a network, guided by structural data. Our measurements reveal a common design with dedicated switch and motor modules. The FliM middle domain (FliMM has extensive connectivity most simply explained by conserved intra and inter-subunit contacts. In contrast, FliG has patchy, complex architecture. Conserved structural motifs form interacting nodes in the coevolution network that wire FliMM to the FliGC C-terminal, four-helix motor module (C3-6. FliG C3-6 coevolution is organized around the torque helix, differently from other ARM domains. The nodes form separated, surface-proximal patches that are targeted by deleterious mutations as in other allosteric systems. The dominant node is formed by the EHPQ motif at the FliMMFliGM contact interface and adjacent helix residues at a central location within FliGM. The node interacts with nodes in the N-terminal FliGc α-helix triad (ARM-C and FliGN. ARM-C, separated from C3-6 by the MFVF motif, has poor intra-network connectivity consistent with its variable orientation revealed by structural data. ARM

Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.

Science.gov (United States)

Popov-Čeleketić, Dušan; Waegemann, Karin; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

2011-06-01

The TIM23 complex mediates translocation of proteins across, and their lateral insertion into, the mitochondrial inner membrane. Translocation of proteins requires both the membrane-embedded core of the complex and its ATP-dependent import motor. Insertion of some proteins, however, occurs in the absence of ATP, questioning the need for the import motor during lateral insertion. We show here that the import motor associates with laterally inserted proteins even when its ATPase activity is not required. Furthermore, our results suggest a role for the import motor in lateral insertion. Thus, the import motor is involved in ATP-dependent translocation and ATP-independent lateral insertion.

Nonlinear Deadbeat Current Control of a Switched Reluctance Motor

OpenAIRE

Rudolph, Benjamin

2009-01-01

High performance current control is critical to the success of the switched reluctance motor (SRM). Yet high motor phase nonlinearities in the SRM place extra burden on the current controller, rendering it the weakest link in SRM control. In contrast to linear motor control techniques that respond to current error, the deadbeat controller calculates the control voltage by the current command, phase current, rotor position and applied phase voltage. The deadbeat controller has demonstrated sup...

Fuzzy – PI controller to control the velocity parameter of Induction Motor

Science.gov (United States)

Malathy, R.; Balaji, V.

2018-04-01

The major application of Induction motor includes the usage of the same in industries because of its high robustness, reliability, low cost, highefficiency and good self-starting capability. Even though it has the above mentioned advantages, it also have some limitations: (1) the standard motor is not a true constant-speed machine, itsfull-load slip varies less than 1 % (in high-horsepower motors).And (2) it is not inherently capable of providing variable-speedoperation. In order to solve the above mentioned problem smart motor controls and variable speed controllers are used. Motor applications involve non linearity features, which can be controlled by Fuzzy logic controller as it is capable of handling those features with high efficiency and it act similar to human operator. This paper presents individuality of the plant modelling. The fuzzy logic controller (FLC)trusts on a set of linguistic if-then rules, a rule-based Mamdani for closed loop Induction Motor model. Themotor model is designed and membership functions are chosenaccording to the parameters of the motor model. Simulation results contains non linearity in induction motor model. A conventional PI controller iscompared practically to fuzzy logic controller using Simulink.

Structure of human Rad51 protein filament from molecular modeling and site-specific linear dichroism spectroscopy

KAUST Repository

Reymer, A.; Frykholm, K.; Morimatsu, K.; Takahashi, M.; Norden, B.

2009-01-01

for central and N-terminal parts of pure (uncomplexed) Rad51 protein by aid of linear dichroism spectroscopy, providing angular orientations of substituted tyrosine residues of Rad51-dsDNA filaments in solution. The structure, validated by comparison

A piezoelectric ultrasonic linear micromotor using a slotted stator.

Science.gov (United States)

Yun, Cheol-Ho; Watson, Brett; Friend, James; Yeo, Leslie

2010-08-01

A novel ultrasonic micro linear motor that uses 1st longitudinal and 2nd bending modes, derived from a bartype stator with a rectangular slot cut through the stator length, has been proposed and designed for end-effect devices of microrobotics and bio-medical applications. The slot structure plays an important role in the motor design, and can be used not only to tune the resonance frequency of the two vibration modes but also to reduce the undesirable longitudinal coupling displacement caused by bending vibration at the end of the stator. By using finite element analysis, the optimal slot dimension to improve the driving tip motion was determined, resulting in the improvement of the motor performance. The trial linear motor, with a weight of 1.6 g, gave a maximum driving velocity of 1.12 m/s and a maximum driving force of 3.4 N. A maximum mechanical output power of 1.1 W was obtained at force of 1.63 N and velocity of 0.68 m/s. The output mechanical power per unit weight was 688 W/kg.

Young Athletes program: impact on motor development.

Science.gov (United States)

Favazza, Paddy C; Siperstein, Gary N; Zeisel, Susan A; Odom, Samuel L; Sideris, John H; Moskowitz, Andrew L

2013-07-01

This study examined the effectiveness of the Young Athletes program to promote motor development in preschool-aged children with disabilities. In the study, 233 children were randomly assigned to a control group or the Young Athletes (YA) intervention group which consisted of 24 motor skill lessons delivered 3 times per week for 8 weeks. Hierarchical Linear Modeling (HLM) showed that children who participated in the YA intervention exhibited mean gains of 7-9 months on the Peabody Developmental Motor Subscales (PDMS) compared with mean gains of 3-5 months for the control group. Children in the YA intervention also exhibited significant gains on the gross motor subscale of the Vineland Teacher Rating Form (VTRF). Teachers and parents reported benefits for children not only in specific motor skills, but also kindergarten readiness skills and social/play skills. The necessity for direct and intentional instruction of motor skills, as well as the challenges of involving families in the YA program, are discussed.

Characterization of a linear epitope on Chlamydia trachomatis serovar L2 DnaK-like protein

DEFF Research Database (Denmark)

Ozkokmen, D; Birkelund, Svend; Christiansen, Gunna

1994-01-01

A cytoplasmic 75-kDa immunogen from Chlamydia trachomatis serovar L2 has previously been characterized as being similar to the Escherichia coli heat shock protein DnaK. We have localized a linear epitope for one monoclonal antibody specific for C. trachomatis DnaK. By use of a recombinant DNA...... technique, the epitope was limited to 14 amino acids. With synthetic peptides, the epitope was further limited to eight amino acids. Six of these amino acids are conserved in bovine HSP70, which has a known three-dimensional structure. The amino acid sequence homologous to the epitope is located in a linear...

Nonlinear Decoupling of Torque and Field Amplitude in an Induction Motor

DEFF Research Database (Denmark)

Rasmussen, Henrik; Vadstrup, P.; Børsting, H.

1997-01-01

A novel approach to control of induction motors, based on nonlinear state feedback, is presented. The resulting scheme gives a linearized input-output decoupling of the torque and the amplitude of the field. The proposed approach is used to design controllers for the field amplitude and the motor...... torque. The method is tested both by simulation and by experiments on a motor drive....

Discrete-Time LPV Current Control of an Induction Motor

DEFF Research Database (Denmark)

Bendtsen, Jan Dimon; Trangbæk, Klaus

2003-01-01

In this paper we apply a new method for gain-scheduled output feedback control of nonlinear systems to current control of an induction motor. The method relies on recently developed controller synthesis results for linear parameter-varying (LPV) systems, where the controller synthesis is formulated...... as a set of linear matrix inequalities with full-block multipliers. A standard nonlinear model of the motor is constructed and written on LPV form. We then show that, although originally developed in continuous time, the controller synthesis results can be applied to a discrete-time model as well without...... further complications. The synthesis method is applied to the model, yielding an LPV discrete-time controller. Finally, the efficiency of the control scheme is validated via simulations as well as on the actual induction motor, both in open-loop current control and when an outer speed control loop...

Porters versus rowers: a unified stochastic model of motor proteins.

Science.gov (United States)

Leibler, S; Huse, D A

1993-06-01

We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical "tight-coupling" mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity, as functions of the ATP concentration and the number of motor enzymes. It explains in a unified way many results of recent in vitro motility assays. More importantly, the theory provides a natural classification scheme for the motors: it correlates the biochemical and mechanical differences between "porters" such as cellular kinesins or dyneins, and "rowers" such as muscular myosins or flagellar dyneins.

Motor Importance of motor assessment in school children: analysis of the reliability of the motor development scale doi: 10.5007/1980-0037.2010v12n6p422

Directory of Open Access Journals (Sweden)

Francisco Rosa Neto

2010-09-01

Full Text Available The objective of this study was to investigate the motor performance of school chil-dren aged 6 to 10 years without learning difficulties (n=101, and to analyze the reliability of the Motor Development Scale (MDS (Rosa Neto, 2002. Descriptive statistics with calculation of the mean, standard deviation, and range was used for data analysis. The internal consistency of the MDS was assessed using Cronbach’s alpha coefficient, and the correlation between variables was determined by Pearson’s linear correlation, with p<0.05. The results showed (1 that motor development was within normal limits in 96% of the children, and (2 a high correlation betwe-en chronological age and general motor age, indicating good internal consistency. These data demonstrate the logic and structured design of the MDS, confirming its reliability.

A Recommended New Approach on Motorization Ratio Calculations of Stepper Motors

Science.gov (United States)

Nalbandian, Ruben; Blais, Thierry; Horth, Richard

2014-01-01

Stepper motors are widely used on most spacecraft mechanisms requiring repeatable and reliable performance. The unique detent torque characteristics of these type of motors makes them behave differently when subjected to low duty cycle excitations where the applied driving pulses are only energized for a fraction of the pulse duration. This phenomenon is even more pronounced in discrete permanent magnet stepper motors used in the space industry. While the inherent high detent properties of discrete permanent magnets provide desirable unpowered holding performance characteristics, it results in unique behavior especially in low duty cycles. Notably, the running torque reduces quickly to the unpowered holding torque when the duty cycle is reduced. The space industry's accepted methodology of calculating the Motorization Ratio (or Torque Margin) is more applicable to systems where the power is continuously applied to the motor coils like brushless DC motors where the cogging torques are low enough not to affect the linear performance of the motors as a function of applied current. This paper summarizes the theoretical and experimental studies performed on a number of space qualified motors under different pulse rates and duty cycles. It is the intention of this paper to introduce a new approach to calculate the Motorization Ratios for discrete permanent magnet steppers under all full and partial duty cycle regimes. The recommended approach defines two distinct relationships to calculate the Motorization Ratio for 100 percent duty cycle and partial duty cycle, when the motor detent (unpowered holding torque) is the main contributor to holding position. These two computations reflect accurately the stepper motor physical behavior as a function of the command phase (ON versus OFF times of the pulses), pointing out how the torque contributors combine. Important points highlighted under this study are the torque margin computations, in particular for well characterized

Multiplex protein pattern unmixing using a non-linear variable-weighted support vector machine as optimized by a particle swarm optimization algorithm.

Science.gov (United States)

Yang, Qin; Zou, Hong-Yan; Zhang, Yan; Tang, Li-Juan; Shen, Guo-Li; Jiang, Jian-Hui; Yu, Ru-Qin

2016-01-15

Most of the proteins locate more than one organelle in a cell. Unmixing the localization patterns of proteins is critical for understanding the protein functions and other vital cellular processes. Herein, non-linear machine learning technique is proposed for the first time upon protein pattern unmixing. Variable-weighted support vector machine (VW-SVM) is a demonstrated robust modeling technique with flexible and rational variable selection. As optimized by a global stochastic optimization technique, particle swarm optimization (PSO) algorithm, it makes VW-SVM to be an adaptive parameter-free method for automated unmixing of protein subcellular patterns. Results obtained by pattern unmixing of a set of fluorescence microscope images of cells indicate VW-SVM as optimized by PSO is able to extract useful pattern features by optimally rescaling each variable for non-linear SVM modeling, consequently leading to improved performances in multiplex protein pattern unmixing compared with conventional SVM and other exiting pattern unmixing methods. Copyright © 2015 Elsevier B.V. All rights reserved.

Sensing surface mechanical deformation using active probes driven by motor proteins

Science.gov (United States)

Inoue, Daisuke; Nitta, Takahiro; Kabir, Arif Md. Rashedul; Sada, Kazuki; Gong, Jian Ping; Konagaya, Akihiko; Kakugo, Akira

2016-01-01

Studying mechanical deformation at the surface of soft materials has been challenging due to the difficulty in separating surface deformation from the bulk elasticity of the materials. Here, we introduce a new approach for studying the surface mechanical deformation of a soft material by utilizing a large number of self-propelled microprobes driven by motor proteins on the surface of the material. Information about the surface mechanical deformation of the soft material is obtained through changes in mobility of the microprobes wandering across the surface of the soft material. The active microprobes respond to mechanical deformation of the surface and readily change their velocity and direction depending on the extent and mode of surface deformation. This highly parallel and reliable method of sensing mechanical deformation at the surface of soft materials is expected to find applications that explore surface mechanics of soft materials and consequently would greatly benefit the surface science. PMID:27694937

Design and analysis of a transversal-flux switched-reluctance-linear-machine pole-pair

Energy Technology Data Exchange (ETDEWEB)

Salo, J.

1999-07-01

The Switched Reluctance technology is probably best suited for industrial low-speed or zerospeed applications where the power can be small but the torque or the force in linear movement cases might be relatively high. Because of its simple structure the Sit-motor is an interesting alternative for low power applications where pneumatic or hydraulic linear drives are to be avoided. This study analyses the basic parts of an LSR-motor which are the two mover poles and one stator pole and which form the 'basic pole pair' in linear-movement transversal-flux switched-reluctance motors. The static properties of the basic pole pair are modelled and the basic design rules are derived. The models developed are validated with experiments. A one-sided one-polepair transversal-flux switched-reluctance-linear-motor prototype is demonstrated and its static properties are measured. The modelling of the static properties is performed with FEM-calculations. Two-dimensional models are accurate enough to model the static key features for the basic dimensioning of LSRmotors. Three-dimensional models must be used in order to get the most accurate calculation results of the static traction force production. The developed dimensioning and modelling methods, which could be systematically validated by laboratory measurements, are the most significant contributions of this thesis. (orig.)

Design and analysis of a transversal-flux switched-reluctance-linear-machine pole-pair

Energy Technology Data Exchange (ETDEWEB)

Salo, J

1999-07-01

The Switched Reluctance technology is probably best suited for industrial low-speed or zerospeed applications where the power can be small but the torque or the force in linear movement cases might be relatively high. Because of its simple structure the Sit-motor is an interesting alternative for low power applications where pneumatic or hydraulic linear drives are to be avoided. This study analyses the basic parts of an LSR-motor which are the two mover poles and one stator pole and which form the 'basic pole pair' in linear-movement transversal-flux switched-reluctance motors. The static properties of the basic pole pair are modelled and the basic design rules are derived. The models developed are validated with experiments. A one-sided one-polepair transversal-flux switched-reluctance-linear-motor prototype is demonstrated and its static properties are measured. The modelling of the static properties is performed with FEM-calculations. Two-dimensional models are accurate enough to model the static key features for the basic dimensioning of LSRmotors. Three-dimensional models must be used in order to get the most accurate calculation results of the static traction force production. The developed dimensioning and modelling methods, which could be systematically validated by laboratory measurements, are the most significant contributions of this thesis. (orig.)

Functions and regulation of the multitasking FANCM family of DNA motor proteins.

Science.gov (United States)

Xue, Xiaoyu; Sung, Patrick; Zhao, Xiaolan

2015-09-01

Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes. © 2015 Xue et al.; Published by Cold Spring Harbor Laboratory Press.

Speed controller for an alternating - current motor

International Nuclear Information System (INIS)

Bolie, V.W.

1984-01-01

A controller for a multi-phase ac motor that is subject to a large inertial load, e.g. an induction motor driving a heavy spinning rotor of a neutron chopper that must be rotated in phase-locked synchronism with a reference pulse train that is representative of an ac power supply signal Esub(L) having a meandering line frequency, includes a sensor which provides a feedback pulse train representative of the actual speed of the motor which is compared (by counting clock pulses between feedback pulses) with a reference clock signal in a computing unit to provide a motor control signal Esub(c). The motor control signal is a weighted linear sum of a speed error signal, a phase error signal, and a drift error signal, the magnitudes of which are recalculated and updated with each revolution of the motor shaft. The speed error signal is constant for large speed errors but highly sensitive to small speed errors. The stator windings of the motor are driven by variable-frequency power amplifiers which are controlled by the motor control signal Esub(c) via PROMs which store digital representations of sine and cosine waveforms in quadrature. (author)

Assessment of global motor performance and gross and fine motor skills of infants attending day care centers.

Science.gov (United States)

Souza, Carolina T; Santos, Denise C C; Tolocka, Rute E; Baltieri, Letícia; Gibim, Nathália C; Habechian, Fernanda A P

2010-01-01

To analyze the global motor performance and the gross and fine motor skills of infants attending two public child care centers full-time. This was a longitudinal study that included 30 infants assessed at 12 and 17 months of age with the Motor Scale of the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). This scale allows the analysis of global motor performance, fine and gross motor performance, and the discrepancy between them. The Wilcoxon test and Spearman's correlation coefficient were used. Most of the participants showed global motor performance within the normal range, but below the reference mean at 12 and 17 months, with 30% classified as having "suspected delays" in at least one of the assessments. Gross motor development was poorer than fine motor development at 12 and at 17 months of age, with great discrepancy between these two subtests in the second assessment. A clear individual variability was observed in fine motor skills, with weak linear correlation between the first and the second assessment of this subtest. A lower individual variability was found in the gross motor skills and global motor performance with positive moderate correlation between assessments. Considering both performance measurements obtained at 12 and 17 months of age, four infants were identified as having a "possible delay in motor development". The study showed the need for closer attention to the motor development of children who attend day care centers during the first 17 months of life, with special attention to gross motor skills (which are considered an integral part of the child's overall development) and to children with suspected delays in two consecutive assessments.

Self-tuning Torque Control of Induction Motors for High Performance Applications

DEFF Research Database (Denmark)

Rasmussen, Henrik

-link voltage a non-linear model of the inverter giving the relation between turn-on times and voltages is developed. A dynamic model of the induction motor based on space phasors is described. The model in a reference frame fixed to the rotor magnetizing current is analyzed in detail and extended with a model......: · To analyze and develop strategies for torque control of induction motors well suited for automatic tuning. · To analyze and develop methods for automatic tuning of the applied controllers. · To develop robust methods for adaptive field oriented control. · To test the final concept on different motors...... for magnetic saturating. The parameters in this non-linear model of the motor and inverter are determined by impressing some special designed stator voltage signals and measuring the stator currents. A s something new in this context a robust current controller is determined by relay experiment before starting...

Asynchronous slip-ring motor synchronized with permanent magnets

Directory of Open Access Journals (Sweden)

Glinka Tadeusz

2017-03-01

Full Text Available The electric LSPMSM motor presented in the paper differs from standard induction motor by rotor design. The insulated start-up winding is located in slots along the rotor circumference. The winding ends are connected to the slip-rings. The rotor core contains permanent magnets. The electromechanical characteristics for synchronous operation were calculated, as were the start-up characteristics for operation with a short-circuited rotor winding. Two model motors were used for the calculations, the V-shaped Permanent Magnet (VPM – Fig. 3, and the Linear Permanent Magnet (IPM – Fig. 4, both rated at 14.5 kW. The advantages of the investigated motor are demonstrated in the conclusions.

Nonlinear decoupling of torque and field amplitude in an induction motor

Energy Technology Data Exchange (ETDEWEB)

Rasmussen, H. [Aalborg University, Aalborg (Denmark); Vadstrup, P.; Boersting, H. [Grundfos A/S, Bjerringbro (Denmark)

1997-12-31

A novel approach to control of induction motors, based on nonlinear state feedback, is presented. The resulting scheme gives a linearized input-output decoupling of the torque and the amplitude of the field. The proposed approach is used to design controllers for the field amplitude and the motor torque. The method is tested both by simulation and by experiments on a motor drive. (orig.) 12 refs.

Proceedings of the international conference on maglev and linear drives

International Nuclear Information System (INIS)

Anon.

1986-01-01

This book contains papers presented at a conference on Maglev and linear drives. Topics covered include: Development of superconducting magnets for the Canadian electrodynamic Maglev vehicle; Power supply system to drive HSST - Expo '86; and Thrust and levitation force characteristics of linear synchronous motors

A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells

International Nuclear Information System (INIS)

Sharma, Aarti; Lambrechts, Anja; Le thi Hao; Le, Thanh T.; Sewry, Caroline A.; Ampe, Christophe; Burghes, Arthur H.M.; Morris, Glenn E.

2005-01-01

Spinal muscular atrophy (SMA) is caused by reduced levels of SMN (survival of motor neurons protein) and consequent loss of motor neurons. SMN is involved in snRNP transport and nuclear RNA splicing, but axonal transport of SMN has also been shown to occur in motor neurons. SMN also binds to the small actin-binding protein, profilin. We now show that SMN and profilin II co-localise in the cytoplasm of differentiating rat PC12 cells and in neurite-like extensions, especially at their growth cones. Many components of known SMN complexes were also found in these extensions, including gemin2 (SIP-1), gemin6, gemin7 and unrip (unr-interacting protein). Coilin p80 and Sm core protein immunoreactivity, however, were seen only in the nucleus. SMN is known to associate with β-actin mRNA and specific hnRNPs in axons and in neurite extensions of cultured nerve cells, and SMN also stimulates neurite outgrowth in cultures. Our results are therefore consistent with SMN complexes, rather than SMN alone, being involved in the transport of actin mRNPs along the axon as in the transport of snRNPs into the nucleus by similar SMN complexes. Antisense knockdown of profilin I and II isoforms inhibited neurite outgrowth of PC12 cells and caused accumulation of SMN and its associated proteins in cytoplasmic aggregates. BIAcore studies demonstrated a high affinity interaction of SMN with profilin IIa, the isoform present in developing neurons. Pathogenic missense mutations in SMN, or deletion of exons 5 and 7, prevented this interaction. The interaction is functional in that SMN can modulate actin polymerisation in vitro by reducing the inhibitory effect of profilin IIa. This suggests that reduced SMN in SMA might cause axonal pathfinding defects by disturbing the normal regulation of microfilament growth by profilins

Features of Synchronous Electronically Commutated Motors in Servomotor Operation Modes

Directory of Open Access Journals (Sweden)

Dirba J.

2017-04-01

Full Text Available The authors consider the features and operation specifics of the synchronous permanent magnet motors and the synchronous reluctance motors with electronic commutation in servomotor operation modes. Calculation results show that mechanical and control characteristics of studied motors are close to a linear shape. The studied motor control is proposed to implement similar to phase control of induction servomotor; it means that angle θ (angle between vectors of the supply voltage and non-load electromotive force or angle ε (angle between rotor direct axis and armature magnetomotive force axis is changed. The analysis results show that synchronous electronically commutated motors could be used as servomotors.

Features of Synchronous Electronically Commutated Motors in Servomotor Operation Modes

Science.gov (United States)

Dirba, J.; Lavrinovicha, L.; Dobriyan, R.

2017-04-01

The authors consider the features and operation specifics of the synchronous permanent magnet motors and the synchronous reluctance motors with electronic commutation in servomotor operation modes. Calculation results show that mechanical and control characteristics of studied motors are close to a linear shape. The studied motor control is proposed to implement similar to phase control of induction servomotor; it means that angle θ (angle between vectors of the supply voltage and non-load electromotive force) or angle ɛ (angle between rotor direct axis and armature magnetomotive force axis) is changed. The analysis results show that synchronous electronically commutated motors could be used as servomotors.

Understanding molecular motor walking along a microtubule: a themosensitive asymmetric Brownian motor driven by bubble formation.

Science.gov (United States)

Arai, Noriyoshi; Yasuoka, Kenji; Koishi, Takahiro; Ebisuzaki, Toshikazu; Zeng, Xiao Cheng

2013-06-12

The "asymmetric Brownian ratchet model", a variation of Feynman's ratchet and pawl system, is invoked to understand the kinesin walking behavior along a microtubule. The model system, consisting of a motor and a rail, can exhibit two distinct binding states, namely, the random Brownian state and the asymmetric potential state. When the system is transformed back and forth between the two states, the motor can be driven to "walk" in one direction. Previously, we suggested a fundamental mechanism, that is, bubble formation in a nanosized channel surrounded by hydrophobic atoms, to explain the transition between the two states. In this study, we propose a more realistic and viable switching method in our computer simulation of molecular motor walking. Specifically, we propose a thermosensitive polymer model with which the transition between the two states can be controlled by temperature pulses. Based on this new motor system, the stepping size and stepping time of the motor can be recorded. Remarkably, the "walking" behavior observed in the newly proposed model resembles that of the realistic motor protein. The bubble formation based motor not only can be highly efficient but also offers new insights into the physical mechanism of realistic biomolecule motors.

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

Science.gov (United States)

Turner, Bradley J; Alfazema, Neza; Sheean, Rebecca K; Sleigh, James N; Davies, Kay E; Horne, Malcolm K; Talbot, Kevin

2014-04-01

Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and genetic reduction of SMN levels exacerbates the phenotype of transgenic SOD1(G93A) mice. Here, we demonstrate that SMN protein is significantly reduced in the spinal cords of patients with sporadic ALS. To test the potential of SMN as a modifier of ALS, we overexpressed SMN in 2 different strains of SOD1(G93A) mice. Neuronal overexpression of SMN significantly preserved locomotor function, rescued motor neurons, and attenuated astrogliosis in spinal cords of SOD1(G93A) mice. Despite this, survival was not prolonged, most likely resulting from SMN mislocalization and depletion of gems in motor neurons of symptomatic mice. Our results reveal that SMN upregulation slows locomotor deficit onset and motor neuron loss in this mouse model of ALS. However, disruption of SMN nuclear complexes by high levels of mutant SOD1, even in the presence of SMN overexpression, might limit its survival promoting effects in this specific mouse model. Studies in emerging mouse models of ALS are therefore warranted to further explore the potential of SMN as a modifier of ALS. Copyright © 2014 Elsevier Inc. All rights reserved.

Split photosystem protein, linear-mapping topology, and growth of structural complexity in the plastid genome of chromera velia

KAUST Repository

Janouškovec, Jan

2013-08-22

The canonical photosynthetic plastid genomes consist of a single circular-mapping chromosome that encodes a highly conserved protein core, involved in photosynthesis and ATP generation. Here, we demonstrate that the plastid genome of the photosynthetic relative of apicomplexans, Chromera velia, departs from this view in several unique ways. Core photosynthesis proteins PsaA and AtpB have been broken into two fragments, which we show are independently transcribed, oligoU-tailed, translated, and assembled into functional photosystem I and ATP synthase complexes. Genome-wide transcription profiles support expression of many other highly modified proteins, including several that contain extensions amounting to hundreds of amino acids in length. Canonical gene clusters and operons have been fragmented and reshuffled into novel putative transcriptional units. Massive genomic coverage by paired-end reads, coupled with pulsed-field gel electrophoresis and polymerase chain reaction, consistently indicate that the C. velia plastid genome is linear-mapping, a unique state among all plastids. Abundant intragenomic duplication probably mediated by recombination can explain protein splits, extensions, and genome linearization and is perhaps the key driving force behind the many features that defy the conventional ways of plastid genome architecture and function. © The Author 2013.

IGF-1 delivery to CNS attenuates motor neuron cell death but does not improve motor function in type III SMA mice.

Science.gov (United States)

Tsai, Li-Kai; Chen, Yi-Chun; Cheng, Wei-Cheng; Ting, Chen-Hung; Dodge, James C; Hwu, Wuh-Liang; Cheng, Seng H; Passini, Marco A

2012-01-01

The efficacy of administering a recombinant adeno-associated virus (AAV) vector encoding human IGF-1 (AAV2/1-hIGF-1) into the deep cerebellar nucleus (DCN) of a type III SMA mouse model was evaluated. High levels of IGF-1 transcripts and protein were detected in the spinal cord at 2 months post-injection demonstrating that axonal connections between the cerebellum and spinal cord were able to act as conduits for the viral vector and protein to the spinal cord. Mice treated with AAV2/1-hIGF-1 and analyzed 8 months later showed changes in endogenous Bax and Bcl-xl levels in spinal cord motor neurons that were consistent with IGF-1-mediated anti-apoptotic effects on motor neurons. However, although AAV2/1-hIGF-1 treatment reduced the extent of motor neuron cell death, the majority of rescued motor neurons were non-functional, as they lacked axons that innervated the muscles. Furthermore, treated SMA mice exhibited abnormal muscle fibers, aberrant neuromuscular junction structure, and impaired performance on motor function tests. These data indicate that although CNS-directed expression of IGF-1 could reduce motor neuron cell death, this did not translate to improvements in motor function in an adult mouse model of type III SMA. Copyright © 2011 Elsevier Inc. All rights reserved.

Cross-cultural analysis of the motor development of Brazilian, Greek and Canadian infants assessed with the Alberta Infant Motor Scale

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Raquel Saccani

2013-09-01

Full Text Available OBJECTIVE: To compare the motor development of infants from three population samples (Brazil, Canada and Greece, to investigate differences in the percentile curves of motor development in these samples, and to investigate the prevalence of motor delays in Brazilian children. METHODS: Observational, descriptive and cross-sectional study with 795 Brazilian infants from zero to 18 months of age, assessed by the Alberta Infant Motor Scale (AIMS at day care centers, nurseries, basic health units and at home. The Brazilian infants' motor scores were compared to the results of two population samples from Greece (424 infants and Canada (2,400 infants. Descriptive statistics was used, with one-sample t-test and binomial tests, being significant p≤0.05. RESULTS: 65.4% of Brazilian children showed typical motor development, although with lower mean scores. In the beginning of the second year of life, the differences in the motor development among Brazilian, Canadian and Greek infants were milder; at 15 months of age, the motor development became similar in the three groups. A non-linear motor development trend was observed. CONCLUSIONS: The lowest motor percentiles of the Brazilian sample emphasized the need for national norms in order to correctly categorize the infant motor development. The different ways of motor development may be a consequence of cultural differences in infant care.

Two-dimensional servo control of surface motor; Surface motor no nijigen servo control

Energy Technology Data Exchange (ETDEWEB)

Ebihara, D; Takahashi, T; Watada, M [Musashi Institute of Technology, Tokyo (Japan)

1995-08-20

Two dimensional (2D) drive system is needed in many aspects of factory automation (FA) and office automation (OA) machines, such as pen drivers in X-Y plotters, X-Y stage for machining, 2D moving robots, etc. Conventional 2D drive systems are consisted from two sets of rotational motor drive and several types of rotary-to-linear transform mechanisms. Linear motors, in these days, have become to be effective as the requirement for high speed increases. We have been studying about Surface Motor which enables 2D drive on a surface by single mover, and the characteristics are measured. Main difficulty of the actuator is that it is short of thrust forces. Also the feasibility is limited because of its vocational uncertainty caused by the open loop control. Our interest is to introduce the closed loop digital control, to obtain required thrust force at any point on the stator. Since open loop control is used, that is, stability point where the thrust force is zero is moved one after another, generated thrust force within the range of synchronization is small. We have been studying about the peculiar expression of exciting currents to generate required direction at all the stator. On the basis of results, two dimensional position feedback system is assembled, which detect the two dimensional location of the mover by optical sensors and direct current instructions are generated for all the four phases of the mover. 14 refs., 11 figs., 1 tab.

Spinal Muscular Atrophy: More than a Disease of Motor Neurons?

Science.gov (United States)

Nash, L A; Burns, J K; Chardon, J Warman; Kothary, R; Parks, R J

2016-01-01

Spinal muscular atrophy (SMA) is the most common genetically inherited neurodegenerative disease resulting in infant mortality. SMA is caused by genetic deletion or mutation in the survival of motor neuron 1 (SMN1) gene, which results in reduced levels of the survival of motor neuron (SMN) protein. SMN protein deficiency preferentially affects α- motor neurons, leading to their degeneration and subsequent atrophy of limb and trunk muscles, progressing to death in severe forms of the disease. More recent studies have shown that SMN protein depletion is detrimental to the functioning of other tissues including skeletal muscle, heart, autonomic and enteric nervous systems, metabolic/endocrine (e.g. pancreas), lymphatic, bone and reproductive system. In this review, we summarize studies discussing SMN protein's function in various cell and tissue types and their involvement in the context of SMA disease etiology. Taken together, these studies indicate that SMA is a multi-organ disease, which suggests that truly effective disease intervention may require body-wide correction of SMN protein levels. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Alteration of protein folding and degradation in motor neuron diseases : Implications and protective functions of small heat shock proteins

NARCIS (Netherlands)

Carra, Serena; Crippa, Valeria; Rusmini, Paola; Boncoraglio, Alessandra; Minoia, Melania; Giorgetti, Elisa; Kampinga, Harm H.; Poletti, Angelo

Motor neuron diseases (MNDs) are neurodegenerative disorders that specifically affect the survival and function of upper and/or lower motor neurons. Since motor neurons are responsible for the control of voluntary muscular movement, MNDs are characterized by muscle spasticity, weakness and atrophy.

Nonlinear control of permanent magnet synchronous motor driving a ...

African Journals Online (AJOL)

This paper presents a non-linear control of permanent magnet synchronous motor (PMSM) fed by a PWM voltage source inverter. To improve the performance of this control technique, the input-output linearization technique is proposed for a system driving a mechanical load with two masses. In order to ensure a steady ...

Design of Linear Control System for Wind Turbine Blade Fatigue Testing

DEFF Research Database (Denmark)

Toft, Anders; Roe-Poulsen, Bjarke Nørskov; Christiansen, Rasmus

2016-01-01

This paper proposes a linear method for wind turbine blade fatigue testing at Siemens Wind Power. The setup consists of a blade, an actuator (motor and load mass) that acts on the blade with a sinusoidal moment, and a distribution of strain gauges to measure the blade flexure. Based...... difficult to control. To make a linear controller, a different approach has been chosen, namely making a controller which is not regulating on the input frequency, but on the input amplitude. A non-linear mechanical model for the blade and the motor has been constructed. This model has been simplified based...... on the desired output, namely the amplitude of the blade. Furthermore, the model has been linearised to make it suitable for linear analysis and control design methods.\\\\ The controller is designed based on a simplified and linearised model, and its gain parameter determined using pole placement. The model...

Linearization of the Bradford Protein Assay

OpenAIRE

Ernst, Orna; Zor, Tsaffrir

2010-01-01

Determination of microgram quantities of protein in the Bradford Coomassie brilliant blue assay is accomplished by measurement of absorbance at 590 nm. This most common assay enables rapid and simple protein quantification in cell lysates, cellular fractions, or recombinant protein samples, for the purpose of normalization of biochemical measurements. However, an intrinsic nonlinearity compromises the sensitivity and accuracy of this method. It is shown that under standard assay conditions, t...

Probing the corticospinal link between the motor cortex and motoneurones: some neglected aspects of human motor cortical function

DEFF Research Database (Denmark)

Petersen, Nicolas Caesar; Butler, Jane E.; Taylor, Janet L.

2010-01-01

of the discharge of motor units have revealed that the rapidly conducting corticospinal axons (stimulated at higher intensities) contribute to drive motoneurones in normal voluntary contractions. There are also major non-linearities generated at a spinal level in the relation between corticospinal output...... magnetic stimulation of the human motor cortex have highlighted the capacity of the cortex to modify its apparent excitability in response to altered afferent inputs, training and various pathologies. Studies using cortical stimulation at 'very low' intensities which elicit only short-latency suppression...

Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway.

Science.gov (United States)

Baertsch, Nathan A; Baker, Tracy L

2017-11-01

Respiratory motoneuron pools must provide rhythmic inspiratory drive that is robust and reliable, yet dynamic enough to respond to respiratory challenges. One form of plasticity that is hypothesized to contribute to motor output stability by sensing and responding to inadequate respiratory neural activity is inactivity-induced phrenic motor facilitation (iPMF), an increase in inspiratory output triggered by a reduction in phrenic synaptic inputs. Evidence suggests that mechanisms giving rise to iPMF differ depending on the pattern of reduced respiratory neural activity (i.e., neural apnea). A prolonged neural apnea elicits iPMF via a spinal TNF-α-induced increase in atypical PKC activity, but little is known regarding mechanisms that elicit iPMF following intermittent neural apnea. We tested the hypothesis that iPMF triggered by intermittent neural apnea requires retinoic acid and protein synthesis. Phrenic nerve activity was recorded in urethane-anesthetized and -ventilated rats treated intrathecally with an inhibitor of retinoic acid synthesis (4-diethlyaminobenzaldehyde, DEAB), a protein synthesis inhibitor (emetine), or vehicle (artificial cerebrospinal fluid) before intermittent (5 episodes, ~1.25 min each) or prolonged (30 min) neural apnea. Both DEAB and emetine abolished iPMF elicited by intermittent neural apnea but had no effect on iPMF elicited by a prolonged neural apnea. Thus different patterns of reduced respiratory neural activity elicit phenotypically similar iPMF via distinct spinal mechanisms. Understanding mechanisms that allow respiratory motoneurons to dynamically tune their output may have important implications in the context of respiratory control disorders that involve varied patterns of reduced respiratory neural activity, such as central sleep apnea and spinal cord injury. NEW & NOTEWORTHY We identify spinal retinoic acid and protein synthesis as critical components in the cellular cascade whereby repetitive reductions in respiratory

Region and task-specific activation of Arc in primary motor cortex of rats following motor skill learning.

Science.gov (United States)

Hosp, J A; Mann, S; Wegenast-Braun, B M; Calhoun, M E; Luft, A R

2013-10-10

Motor learning requires protein synthesis within the primary motor cortex (M1). Here, we show that the immediate early gene Arc/Arg3.1 is specifically induced in M1 by learning a motor skill. Arc mRNA was quantified using a fluorescent in situ hybridization assay in adult Long-Evans rats learning a skilled reaching task (SRT), in rats performing reaching-like forelimb movement without learning (ACT) and in rats that were trained in the operant but not the motor elements of the task (controls). Apart from M1, Arc expression was assessed within the rostral motor area (RMA), primary somatosensory cortex (S1), striatum (ST) and cerebellum. In SRT animals, Arc mRNA levels in M1 contralateral to the trained limb were 31% higher than ipsilateral (pmotor skill learning in rats. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Identification and characterization of two linear epitope motifs in hepatitis E virus ORF2 protein.

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Heng Wang

Full Text Available Hepatitis E virus (HEV is responsible for hepatitis E, which represents a global public health problem. HEV genotypes 3 and 4 are reported to be zoonotic, and animals are monitored for HEV infection in the interests of public hygiene and food safety. The development of novel diagnostic methods and vaccines for HEV in humans is thus important topics of research. Opening reading frame (ORF 2 of HEV includes both linear and conformational epitopes and is regarded as the primary candidate for vaccines and diagnostic tests. We investigated the precise location of the HEV epitopes in the ORF2 protein. We prepared four monoclonal antibodies (mAbs against genotype 4 ORF2 protein and identified two linear epitopes, G438IVIPHD444 and Y457DNQH461, corresponding to two of these mAbs using phage display biopanning technology. Both these epitopes were speculated to be universal to genotypes 1, 2, 3, 4, and avian HEVs. We also used two 12-mer fragments of ORF2 protein including these two epitopes to develop a peptide-based enzyme-linked immunosorbent assay (ELISA to detect HEV in serum. This assay demonstrated good specificity but low sensitivity compared with the commercial method, indicating that these two epitopes could serve as potential candidate targets for diagnosis. Overall, these results further our understanding of the epitope distribution of HEV ORF2, and provide important information for the development of peptide-based immunodiagnostic tests to detect HEV in serum.

Functions of myosin motors tailored for parasitism

DEFF Research Database (Denmark)

Mueller, Christina; Graindorge, Arnault; Soldati-Favre, Dominique

2017-01-01

Myosin motors are one of the largest protein families in eukaryotes that exhibit divergent cellular functions. Their roles in protozoans, a diverse group of anciently diverged, single celled organisms with many prominent members known to be parasitic and to cause diseases in human and livestock......, are largely unknown. In the recent years many different approaches, among them whole genome sequencing, phylogenetic analyses and functional studies have increased our understanding on the distribution, protein architecture and function of unconventional myosin motors in protozoan parasites. In Apicomplexa......, myosins turn out to be highly specialized and to exhibit unique functions tailored to accommodate the lifestyle of these parasites....

The relationships between gross motor coordination and sport-specific skills in adolescent non-athletes

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Chagas Daniel V

2017-12-01

Full Text Available Purpose. While the usefulness of gross motor coordination score as predictor of sports performance in young athletes has been demonstrated, practical applications in the settings where the focus is not on elite performance is limited. Further, little is known about the extent to which gross motor coordination score is associated with sport-specific skills among adolescent nonathletes. The aim of this study was to analyse the relationship between the degree of gross motor coordination and execution in specific volleyball tests among adolescent non-athletes. Methods. The total of 34 students (27 females and 7 males aged 13-14 years who regularly participated in volleyball during physical education classes were randomly recruited. Gross motor coordination was assessed with the Körperkoordinationstest für Kinder. Motor performance on volley-specific skills was indicated by two product-oriented tasks: volleyball under service and service reception. Correlation and linear regression analyses were applied to examine the associations between motor coordination scores and motor performance in volley-specific skills. Results. Motor coordination score was positively correlated with motor performance on specific skills (r = 0.503, p = 0.02. Linear regression analysis revealed that motor coordination score accounted for 23% of the variance in the motor performance on volleyball skills (R2 = 0.253, R2 adjusted = 0.230, F = 10.836, p = 0.02. Conclusions. The degree of gross motor coordination seems to play a significant role in the execution of specific volleyball tasks.

Fuzzy control of small servo motors

Science.gov (United States)

Maor, Ron; Jani, Yashvant

1993-01-01

To explore the benefits of fuzzy logic and understand the differences between the classical control methods and fuzzy control methods, the Togai InfraLogic applications engineering staff developed and implemented a motor control system for small servo motors. The motor assembly for testing the fuzzy and conventional controllers consist of servo motor RA13M and an encoder with a range of 4096 counts. An interface card was designed and fabricated to interface the motor assembly and encoder to an IBM PC. The fuzzy logic based motor controller was developed using the TILShell and Fuzzy C Development System on an IBM PC. A Proportional-Derivative (PD) type conventional controller was also developed and implemented in the IBM PC to compare the performance with the fuzzy controller. Test cases were defined to include step inputs of 90 and 180 degrees rotation, sine and square wave profiles in 5 to 20 hertz frequency range, as well as ramp inputs. In this paper we describe our approach to develop a fuzzy as well as PH controller, provide details of hardware set-up and test cases, and discuss the performance results. In comparison, the fuzzy logic based controller handles the non-linearities of the motor assembly very well and provides excellent control over a broad range of parameters. Fuzzy technology, as indicated by our results, possesses inherent adaptive features.

Motor Unit Interpulse Intervals During High Force Contractions.

Science.gov (United States)

Stock, Matt S; Thompson, Brennan J

2016-01-01

We examined the means, medians, and variability for motor-unit interpulse intervals (IPIs) during voluntary, high force contractions. Eight men (mean age = 22 years) attempted to perform isometric contractions at 90% of their maximal voluntary contraction force while bipolar surface electromyographic (EMG) signals were detected from the vastus lateralis and vastus medialis muscles. Surface EMG signal decomposition was used to determine the recruitment thresholds and IPIs of motor units that demonstrated accuracy levels ≥ 96.0%. Motor units with high recruitment thresholds demonstrated longer mean IPIs, but the coefficients of variation were similar across all recruitment thresholds. Polynomial regression analyses indicated that for both muscles, the relationship between the means and standard deviations of the IPIs was linear. The majority of IPI histograms were positively skewed. Although low-threshold motor units were associated with shorter IPIs, the variability among motor units with differing recruitment thresholds was comparable.

The motor intervention as delays prevention factor in motor and cognitive development of infants during the hospital stay

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arolina Panceri

2017-09-01

Full Text Available Introduction: Cognitive-motor tasks intervention is beneficial for the infant’s motor and cognitive development. These interventions in the hospital setting, have been widely studied in neonatal intensive care units, however, few studies evaluate child development within pediatric units. Objective: To evaluate the impact of cognitive-motor intervention in motor and cognitive development of infants hospitalized with respiratory diseases. Method: The research was characterized as quasi-experimental, 22 babies hospitalized in the pediatric unit for respiratory disease were divided into 2 groups (10 in the control group and 12 in the intervention group without significant differences in biological and socioeconomic data. The mean age was 5.50 months (SD ± 4.51, ranging between 1 and 16 months. Questionnaire was conducted with the infant’s parent/guardian for sample characterization. The Alberta Infant Motor Scale (AIMS and the Bayley Scales of Infant Development (BSID-III was used to evaluate motor e cognitive development. Data analysis was performed using descriptive statistics, Student’s t test, General Linear Model and One Way ANOVA. Results: The results show a significant interaction between group x time in motor and cognitive scores. When comparing the two times, the intervention group changed positively and significantly from pre- to post-intervention in motor and cognitive scores. The same was not observed for the control group. Conclusion: The results of this study suggest that the intervention during the hospital stay contributes positively to the motor and cognitive development.

Synchronization of low- and high-threshold motor units.

Science.gov (United States)

Defreitas, Jason M; Beck, Travis W; Ye, Xin; Stock, Matt S

2014-04-01

We examined the degree of synchronization for both low- and high-threshold motor unit (MU) pairs at high force levels. MU spike trains were recorded from the quadriceps during high-force isometric leg extensions. Short-term synchronization (between -6 and 6 ms) was calculated for every unique MU pair for each contraction. At high force levels, earlier recruited motor unit pairs (low-threshold) demonstrated relatively low levels of short-term synchronization (approximately 7.3% extra firings than would have been expected by chance). However, the magnitude of synchronization increased significantly and linearly with mean recruitment threshold (reaching 22.1% extra firings for motor unit pairs recruited above 70% MVC). Three potential mechanisms that could explain the observed differences in synchronization across motor unit types are proposed and discussed. Copyright © 2013 Wiley Periodicals, Inc.

Linear associations between clinically assessed upper motor neuron disease and diffusion tensor imaging metrics in amyotrophic lateral sclerosis.

Science.gov (United States)

Woo, John H; Wang, Sumei; Melhem, Elias R; Gee, James C; Cucchiara, Andrew; McCluskey, Leo; Elman, Lauren

2014-01-01

To assess the relationship between clinically assessed Upper Motor Neuron (UMN) disease in Amyotrophic Lateral Sclerosis (ALS) and local diffusion alterations measured in the brain corticospinal tract (CST) by a tractography-driven template-space region-of-interest (ROI) analysis of Diffusion Tensor Imaging (DTI). This cross-sectional study included 34 patients with ALS, on whom DTI was performed. Clinical measures were separately obtained including the Penn UMN Score, a summary metric based upon standard clinical methods. After normalizing all DTI data to a population-specific template, tractography was performed to determine a region-of-interest (ROI) outlining the CST, in which average Mean Diffusivity (MD) and Fractional Anisotropy (FA) were estimated. Linear regression analyses were used to investigate associations of DTI metrics (MD, FA) with clinical measures (Penn UMN Score, ALSFRS-R, duration-of-disease), along with age, sex, handedness, and El Escorial category as covariates. For MD, the regression model was significant (p = 0.02), and the only significant predictors were the Penn UMN Score (p = 0.005) and age (p = 0.03). The FA regression model was also significant (p = 0.02); the only significant predictor was the Penn UMN Score (p = 0.003). Measured by the template-space ROI method, both MD and FA were linearly associated with the Penn UMN Score, supporting the hypothesis that DTI alterations reflect UMN pathology as assessed by the clinical examination.

Dynamics of relaxation to a stationary state for interacting molecular motors

Science.gov (United States)

Gomes, Luiza V. F.; Kolomeisky, Anatoly B.

2018-01-01

Motor proteins are active enzymatic molecules that drive a variety of biological processes, including transfer of genetic information, cellular transport, cell motility and muscle contraction. It is known that these biological molecular motors usually perform their cellular tasks by acting collectively, and there are interactions between individual motors that specify the overall collective behavior. One of the fundamental issues related to the collective dynamics of motor proteins is the question if they function at stationary-state conditions. To investigate this problem, we analyze a relaxation to the stationary state for the system of interacting molecular motors. Our approach utilizes a recently developed theoretical framework, which views the collective dynamics of motor proteins as a totally asymmetric simple exclusion process of interacting particles, where interactions are taken into account via a thermodynamically consistent approach. The dynamics of relaxation to the stationary state is analyzed using a domain-wall method that relies on a mean-field description, which takes into account some correlations. It is found that the system quickly relaxes for repulsive interactions, while attractive interactions always slow down reaching the stationary state. It is also predicted that for some range of parameters the fastest relaxation might be achieved for a weak repulsive interaction. Our theoretical predictions are tested with Monte Carlo computer simulations. The implications of our findings for biological systems are briefly discussed.

Linear viscoelastic characterization from filament stretching rheometry

DEFF Research Database (Denmark)

Wingstrand, Sara Lindeblad; Alvarez, Nicolas J.; Hassager, Ole

to measure both linear and nonlinear dynamics on a single apparatus. With a software modification to the FSR motor control, we show that linear viscoelasticity can be measured via small amplitude squeeze flow (SASF). Squeeze flow is a combination of both shear and extensional flow applied by axially......Traditionally, linear viscoelasticity is measured using small amplitude oscillatory shear flow. Due to experimental difficulties, shear flows are predominately confined to the linear and mildly nonlinear regime. On the other hand, extensional flows have proven more practical in measuring...... viscoelasticity well into the nonlinear regime. Therefore at present, complete rheological characterization of a material requires two apparatuses: a shear and an extensional rheometer. This work is focused on developing a linear viscoelastic protocol for the filament stretching rheometer (FSR) in order...

Fuzzy Logic Controlled Solar Module for Driving Three- Phase Induction Motor

Science.gov (United States)

Afiqah Zainal, Nurul; Sooi Tat, Chan; Ajisman

2016-02-01

Renewable energy produced by solar module gives advantages for generated three- phase induction motor in remote area. But, solar module's ou tput is uncertain and complex. Fuzzy logic controller is one of controllers that can handle non-linear system and maximum power of solar module. Fuzzy logic controller used for Maximum Power Point Tracking (MPPT) technique to control Pulse-Width Modulation (PWM) for switching power electronics circuit. DC-DC boost converter used to boost up photovoltaic voltage to desired output and supply voltage source inverter which controlled by three-phase PWM generated by microcontroller. IGBT switched Voltage source inverter (VSI) produced alternating current (AC) voltage from direct current (DC) source to control speed of three-phase induction motor from boost converter output. Results showed that, the output power of solar module is optimized and controlled by using fuzzy logic controller. Besides that, the three-phase induction motor can be drive and control using VSI switching by the PWM signal generated by the fuzzy logic controller. This concluded that the non-linear system can be controlled and used in driving three-phase induction motor.

Age-related motor unit remodeling in the Tibialis Anterior.

Science.gov (United States)

Siddiqi, Ariba; Kumar, Dinesh; Arjunan, Sridhar

2015-01-01

Limited studies exist on the use of surface electromyogram (EMG) signal features to detect age-related motor unit remodeling in the Tibialis Anterior. Motor unit remodeling leads to declined muscle strength and force steadiness during submaximal contractions which are factors for risk of falls in the elderly. This study investigated the remodeling phenomena in the Tibialis Anterior using sample entropy and higher order statistics. Eighteen young (26.1 ± 2.9 years) and twelve elderly (68.7 ± 9.0 years) participants performed isometric dorsiflexion of the ankle at 20% maximal voluntary contraction (MVC) and their Tibialis Anterior (TA) EMG was recorded. Sample entropy, Gaussianity and Linearity Test statistics were calculated from the recorded EMG for each MVC. Shapiro-Wilk test was used to determine normality, and either a two-tail student t-test or Wilcoxon rank sum test was performed to determine significant difference in the EMG features between the young and old cohorts. Results show age-related motor unit remodeling to be depicted by decreased sample entropy (p <; 0.1), increased non-Gaussianity (p <; 0.05) and lesser degree of linearity in the elderly. This is due to the increased sparsity of the MUAPs as a result of the denervation-reinnervation process, and the decrease in total number of motor units.