[Lack of association between MMR vaccination and the incidence of autism in children: a case-control study].

Science.gov (United States)

Mrozek-Budzyn, Dorota; Kiełtyka, Agnieszka; Majewska, Renata

2009-01-01

The matched case-control study has been undertook to investigate whether measles, mumps, and rubella (MMR) vaccine may be casually associated with autism in children. Cases were children to 14-year old with diagnosis of core autism or atypical autism. Controls were matched on age, sex and general practice. The 96 cases and 192 controls were included. The study provides strong evidence against association of autism with both MMR and a single measles individual vaccine. Additionally children vaccinated with MMR, regardless of age of vaccination (to 18th, 24th and 36th month of life), had risk equal half of that of single measles vaccinated (for vaccinated to 18th month OR=0.41 95%PU: 0.20-0.85). Our findings confirm that MMR vaccination is not associated with an increased risk of autism in children.

Knowledge, attitudes and opinions towards measles and the MMR vaccine across two NSW cohorts.

Science.gov (United States)

Brieger, Daniel; Edwards, Matthew; Mudgil, Poonam; Whitehall, John

2017-12-01

Although the number of national measles cases has greatly decreased since 1980s, there has been resurgence in disease incidence in recent years. While parental knowledge and attitudes toward both disease and vaccinations are known to influence vaccine uptake, the contribution of these factors toward vaccination rates in NSW populations has not been studied. The aim of this study was to investigate the knowledge and opinions on measles and MMR vaccine in NSW Central and North Coast regions. Parents (n=201) of children <12 years were surveyed with a purpose design survey at public beaches at the Central Coast and community markets at the North Coast. Eight per cent of respondents reported not immunising their child with MMR vaccine. Most respondents recognised that measles is a highly contagious disease. Non-immunisers were found to be older, had a lower perceived severity of measles, were less likely to agree with the efficacy and safety of the vaccine, and were more likely to have encountered someone who had suffered side-effects of the vaccine. There is considerable concern over safety of MMR vaccine among non-immunisers. Implications for public health: Improving confidence in MMR vaccine should be a target of future public health interventions. © 2017 The Authors.

Parental decision-making in uptake of the MMR vaccination: a systematic review of qualitative literature.

Science.gov (United States)

Allan, N; Harden, J

2015-12-01

Controversy has surrounded MMR vaccination in the aftermath of Wakefield's 1998 paper suggesting links between MMR and the development of pervasive developmental disorder in children. The paper sparked off media debate and contributed to a lack of parental trust in health-care providers and reduction in MMR uptake. This review aims to identify and evaluate research on the subject, with a view to present the reasons behind, and influences on parental decision-making in relation to MMR. Systematic search strategy identified 14 relevant papers on which thematic analysis was performed. Themes identified were categorized as follows: perceptions of risk; roles and responsibility; experience and knowledge. There were limited changes in parental decision-making factors over the time period despite an increase in uptake. Many studies fail to differentiate between accepters and rejecters, making it difficult to draw out clear conclusions. Policymakers need to adapt information provided to address these concerns. Future research should focus more on distinguishing between accepters and rejecters to determine which factors can alter outcome. © The Author 2014. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program

Directory of Open Access Journals (Sweden)

Eliane Matos dos Santos

2014-06-01

Full Text Available A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles, mumps and rubella (MMR immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009, without other vaccines administered during the period from 30 days before to 30 days after vaccination. A previous study conducted in Brazil in 2007, in 1,769 children ranging from 12-15 months of age vaccinated against yellow fever and MMR simultaneously or at intervals of 30 days or more between doses, had shown low seroconversion for mumps regardless of the interval between administration of the two vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0 seroconversion rate for mumps. All children seroconverted for measles and rubella. After revaccination, high antibody titres and seroconversion rates were achieved against mumps. The results of this study and others suggest that two MMR doses confer optimal immunoresponses for all three antigens and the possible need for additional doses should be studied taking into account not only serological, but also epidemiological data, as there is no serological correlate of protection for mumps.

License and entry strategies for an outside innovator under duopoly with combination of royalty and fixed fee

OpenAIRE

Hattori, Masahiko; Tanaka, Yasuhito

2017-01-01

We consider a choice of options for an innovating firm to enter the market with or without licensing its new cost-reducing technology to the incumbent firm using a combination of a royalty per output and a fixed license fee, or to license its technology without entry. With general demand and cost functions we show the following results. When the innovating firm licenses its technology to the incumbent firm without entry, the optimal royalty rate per output for the innovating firm is zero with...

Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast.

Science.gov (United States)

Swayne, Theresa C; Zhou, Chun; Boldogh, Istvan R; Charalel, Joseph K; McFaline-Figueroa, José Ricardo; Thoms, Sven; Yang, Christine; Leung, Galen; McInnes, Joseph; Erdmann, Ralf; Pon, Liza A

2011-12-06

Mitochondria accumulate at neuronal and immunological synapses and yeast bud tips and associate with the ER during phospholipid biosynthesis, calcium homeostasis, and mitochondrial fission. Here we show that mitochondria are associated with cortical ER (cER) sheets underlying the plasma membrane in the bud tip and confirm that a deletion in YPT11, which inhibits cER accumulation in the bud tip, also inhibits bud tip anchorage of mitochondria. Time-lapse imaging reveals that mitochondria are anchored at specific sites in the bud tip. Mmr1p, a member of the DSL1 family of tethering proteins, localizes to punctate structures on opposing surfaces of mitochondria and cER sheets underlying the bud tip and is recovered with isolated mitochondria and ER. Deletion of MMR1 impairs bud tip anchorage of mitochondria without affecting mitochondrial velocity or cER distribution. Deletion of the phosphatase PTC1 results in increased Mmr1p phosphorylation, mislocalization of Mmr1p, defects in association of Mmr1p with mitochondria and ER, and defects in bud tip anchorage of mitochondria. These findings indicate that Mmr1p contributes to mitochondrial inheritance as a mediator of anchorage of mitochondria to cER sheets in the yeast bud tip and that Ptc1p regulates Mmr1p phosphorylation, localization, and function. Copyright © 2011 Elsevier Ltd. All rights reserved.

A novel measles outbreak control strategy in the Netherlands in 2013-2014 using a national electronic immunization register: A study of early MMR uptake and its determinants.

Science.gov (United States)

Nic Lochlainn, Laura M; Woudenberg, Tom; van Lier, Alies; Zonnenberg, Irmgard; Philippi, Marvin; de Melker, Hester E; Hahné, Susan J M

2017-10-13

During a large measles outbreak in the Netherlands in 2013-2014, infants aged 6-14months living in municipalities with low (<90%) measles-mumps-rubella (MMR) coverage were individually invited for an early MMR using the national electronic immunization register, Præventis. We estimated uptake of early MMR prior to and during the 2013-2014 outbreak and assessed determinants for early MMR vaccination. We obtained vaccination records from Præventis, and defined early MMR as vaccination before 415days (13months) of age. A multi-level multivariable logistic regression model, restricted to infants with three diphtheria-pertussis-tetanus-polio (DPTP) vaccinations was used to examine the association between early MMR uptake and sex, parents' country of birth, socioeconomic status (SES; at postcode level) and voting proportions for the Reformed Political Party (SGP; at municipal level), used as a proxy for religious objections towards vaccination. In the 29 municipalities with low MMR coverage, uptake of early MMR was 0.5-2.2% prior to the outbreak. Between July 2013 and March 2014, 5,800 (57%) invited infants received an early MMR. Among infants with three DPTP, 70% received an early MMR. Only 1% of infants without prior DPTP received an early MMR. Lower early MMR uptake was associated with a higher SGP voter-ship (OR 0.89 per 5% increase, 95%CI 0.83-0.96), parents' with unknown country of birth (OR 0.66 95%CI 0.47-0.93) and compared with very high SES, high SES had significantly lower early MMR uptake (OR 0.66 95%CI 0.50-0.87). This is the first study describing use of Præventis during an outbreak and to assess determinants of early MMR uptake. More than half of invited infants obtained an early MMR. SES, parents' with unknown country of birth and religious objections towards vaccination were found to be associated with lower early MMR uptake. In future outbreaks, these determinants could be used to tailor intervention strategies. Copyright © 2017. Published by

Information, education, and health behaviors: Evidence from the MMR vaccine autism controversy.

Science.gov (United States)

Chang, Lenisa V

2018-05-02

In the wake of strong, although later refuted, claims of a link between autism and the measles-mumps-rubella (MMR) vaccine, I examine whether fewer parents immunized or delayed vaccinations for their children and if there was a differential response by mother's education level. Using various controls and a differencing strategy that compares in MMR take-up with other vaccines, I find that the MMR-autism controversy led to a decline in the immediate years and that there were negative spillovers onto other vaccines. I also find evidence that more highly educated mothers responded more strongly to the controversy either by not immunizing their children altogether or, to a lesser degree, delaying vaccination. Moreover, the educational gap was greater in states where there was greater media attention devoted to the controversy. This is consistent with the health allocative efficiency hypothesis whereby part of the education gradient in health outcomes is due to more-educated individuals absorbing and responding to health information more quickly. However, unlike in the United Kingdom, where previous studies find that the gap was eliminated after the link was refuted, the evidence for the United States suggests that the educational gap persisted. Copyright © 2018 John Wiley & Sons, Ltd.

MMR (measles, mumps, and rubella) vaccine - what you need to know

Science.gov (United States)

... taken in its entirety from the CDC MMR (Measles, Mumps, & Rubella) Vaccine Information Statement (VIS): www.cdc. ... Why get vaccinated? Measles, mumps, and rubella are viral diseases that can ... Before vaccines, these diseases were very common in ...

Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.

NARCIS (Netherlands)

Feitsma, H.; Akay, A.; Cuppen, E.

2008-01-01

S(N)1-type alkylating agents, like N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU), are potent mutagens. Exposure to alkylating agents gives rise to O(6)-alkylguanine, a modified base that is recognized by DNA mismatch repair (MMR) proteins but is not repairable, resulting in

[The relationship between MMR vaccination level and the number of new cases of autism in children].

Science.gov (United States)

Mrozek-Budzyn, Dorota; Kiełtyka, Agnieszka

2008-01-01

The MMR vaccination coverage in Malopolskie voivodeship improved rapidly and finally reached a high level during last years. The number of new cases of autism spectrum disorders in children during that time revealed a slightly rising but not significant trend, while the number of childhood autism were stable. Ecological study showed no correlation between MMR vaccination and an increased risk of childhood autism and autism spectrum disorders in children.

Intralesional tuberculin (PPD) versus measles, mumps, rubella (MMR) vaccine in treatment of multiple warts: a comparative clinical and immunological study.

Science.gov (United States)

Shaheen, Maha Adel; Salem, Samar Abdallah M; Fouad, Dina Adel; El-Fatah, Abeer Aly Abd

2015-01-01

Intralesional purified protein derivative (PPD) or mumps, measles, rubella (MMR) were not previously compared regarding their efficacy or mechanism of action in treatment of warts. We aimed to compare their efficacy in treatment of multiple warts and investigate their effect on serum interleukin (IL)-4 and IL-12. Thirty patients with multiple warts were included (10 treated with PPD, 10 with MMR, and 10 with normal saline (control)). Injection was done every 3 weeks until clearance or maximum of three treatments. Clinical response of target and distant warts was evaluated. Serum ILs-4 and -12 were assessed before and after treatment. A significantly higher rate of complete response was found in target and distant warts with PPD (60% each) and MMR (80%, 40%, respectively) compared with controls (0%), with no significant difference between both treatments. After treatment, the control group showed the lowest serum IL-12 and IL-4 levels compared with the MMR- and PPD-treated groups with statistically significant difference in between. MMR resulted in a significantly higher serum IL-12 than PPD. With PPD, IL-4 was increased with statistically significant change compared with pretreat-ment level. Intralesional PPD and MMR show comparable efficacy and safety in treatment of multiple warts. Serum ILs-4 and-12 increase following antigen injection. © 2015 Wiley Periodicals, Inc.

DEVELOPMENT AND DEPLOYMENT ASSESSMENT OF A MELT-DOWN PROOF MODULAR MICRO REACTOR (MDP-MMR)

Energy Technology Data Exchange (ETDEWEB)

Hawari, Ayman I.; Venneri, Francesco

2018-04-02

The objective of this project is to perform feasibility assessment and technology gap analysis and establish a development roadmap for an innovative and highly compact Micro Modular Reactor (MMR) concept that integrates power production, power conversion and electricity generation in a single unit. The MMR is envisioned to use fully ceramic micro-encapsulated (FCM) fuel, a particularly robust form of TRISO fuel, and to be gas-cooled (e.g., He or CO2) and capable of generating power in the range of 10 to 40 MW-thermal. It is designed to be absolutely melt-down proof (MDP) under all circumstances including complete loss of coolant scenarios with no possible release of radioactive material, to be factory produced, to have a cycle length of greater than 20 years, and to be highly proliferation resistant. In addition, it will be transportable, retrievable and suitable for use in remote areas. As such, the MDP-MMR will represent a versatile reactor concept that is suitable for use in various applications including electricity generation, process heat utilization and propulsion.

The two-dose measles, mumps, and rubella (MMR) immunisation schedule: factors affecting maternal intention to vaccinate.

OpenAIRE

Pareek, M; Pattison, H M

2000-01-01

BACKGROUND: In the light of sub-optimal uptake of the measles, mumps, and rubella (MMR) vaccination, we investigated the factors that influence the intentions of mothers to vaccinate. METHOD: A cross-sectional survey of 300 mothers in Birmingham with children approaching a routine MMR vaccination was conducted using a postal questionnaire to measure: intention to vaccinate, psychological variables, knowledge of the vaccine, and socioeconomic status. The vaccination status of the children was ...

Autism occurrence by MMR vaccine status among US children with older siblings with and without autism.

Science.gov (United States)

Jain, Anjali; Marshall, Jaclyn; Buikema, Ami; Bancroft, Tim; Kelly, Jonathan P; Newschaffer, Craig J

2015-04-21

Despite research showing no link between the measles-mumps-rubella (MMR) vaccine and autism spectrum disorders (ASD), beliefs that the vaccine causes autism persist, leading to lower vaccination levels. Parents who already have a child with ASD may be especially wary of vaccinations. To report ASD occurrence by MMR vaccine status in a large sample of US children who have older siblings with and without ASD. A retrospective cohort study using an administrative claims database associated with a large commercial health plan. Participants included children continuously enrolled in the health plan from birth to at least 5 years of age during 2001-2012 who also had an older sibling continuously enrolled for at least 6 months between 1997 and 2012. MMR vaccine receipt (0, 1, 2 doses) between birth and 5 years of age. ASD status defined as 2 claims with a diagnosis code in any position for autistic disorder or other specified pervasive developmental disorder (PDD) including Asperger syndrome, or unspecified PDD (International Classification of Diseases, Ninth Revision, Clinical Modification 299.0x, 299.8x, 299.9x). Of 95,727 children with older siblings, 994 (1.04%) were diagnosed with ASD and 1929 (2.01%) had an older sibling with ASD. Of those with older siblings with ASD, 134 (6.9%) had ASD, vs 860 (0.9%) children with unaffected siblings (P siblings, vs 73% (n = 1409) at age 2 years and 86% (n = 1660) at age 5 years for children with affected siblings. MMR vaccine receipt was not associated with an increased risk of ASD at any age. For children with older siblings with ASD, at age 2, the adjusted relative risk (RR) of ASD for 1 dose of MMR vaccine vs no vaccine was 0.76 (95% CI, 0.49-1.18; P = .22), and at age 5, the RR of ASD for 2 doses compared with no vaccine was 0.56 (95% CI, 0.31-1.01; P = .052). For children whose older siblings did not have ASD, at age 2, the adjusted RR of ASD for 1 dose was 0.91 (95% CI, 0.67-1.20; P = .50) and at age 5

Intentions to use a novel Zika vaccine: the effects of misbeliefs about the MMR vaccine and perceptions about Zika.

Science.gov (United States)

Ophir, Yotam; Jamieson, Kathleen Hall

2018-03-15

People's intentions to use vaccines are influenced by their beliefs about both the specific vaccine and the disease it prevents. In the absence of firm beliefs about Zika virus (ZIKV), individuals may base their intentions to vaccinate against it on beliefs about other vaccines, and specifically the misbelief that MMR causes autism. A survey of 3337 Americans, using a random-digit-dialing sample of landline telephone households and cell-phones. Intentions to use a Zika vaccine were influenced by beliefs about Zika, science in general, and MMR. Intentions were positively influenced by perceived severity of and vulnerability to Zika, as well as belief in science's efficacy. However, intentions were negatively influenced by the belief that MMR causes autism in children. The misbelief about MMR and autism may reduce people's intentions to use a new Zika vaccine. However, perceptions of severity of and vulnerability to Zika may increase intentions. Implications for science educators and public health officials are discussed.

INTRALESIONAL MEASLES, MUMPS AND RUBELLA (MMR VACCINE-AN EFFECTIVE THERAPEUTIC TOOL IN THE TREATMENT OF WART

Directory of Open Access Journals (Sweden)

Raju

2015-11-01

Full Text Available BACKGROUND: Warts are common cutaneous viral infection. Various therapeutic modalities have been using in treatment of wart, but none of them are standardised. Immunotherapy is new current approach in the treatment of wart. AIMS: To know the efficacy and safety profile of Measles Mumps Rubella (MMR Vaccine in the treatment of wart. METHODS: MMR vaccine was injected into a largest single wart intralesionally and subsequent injections given every 2 weeks apart for about 3 to 5 times. Every month followup of patients was done to know the clearance of wart. RESULTS: Complete remission of warts seen in 70.4% of patients, partial remission seen in 22.2% and no response was seen in 7.4% of patients. No serious adverse side effects were seen in the current study. CONCLUSION: MMR vaccine can be considered as a safe, effective, inexpensive intralesional immunotherapeutic modality in the treatment of wart.

76 FR 53492 - South Carolina Public Service Authority (Also Referred to as Santee Cooper); Combined Licenses...

Science.gov (United States)

2011-08-26

... Carolina Public Service Authority (Also Referred to as Santee Cooper); Combined Licenses for Virgil C... as Santee Cooper), for two Title 10 of the Code of Federal Regulations (10 CFR) part 52 combined... Service Authority (Also Referred to as Santee Cooper) Application for the Virgil C. Summer Nuclear Station...

License and entry strategies for an outside innovator in duopoly with combination of royalty and fixed fee under vertical differentiation

OpenAIRE

Hattori, Masahiko; Tanaka, Yasuhito

2017-01-01

We consider a choice of options for an innovating firm in duopoly under vertical differentiation to enter the market with or without licensing its technology for producing a higher quality good to the incumbent firm using a combination of a royalty per output and a fixed license fee, or to license its technology without entry. With general distribution function of consumers' taste parameter and cost function we will show that when the innovating firm licenses its technology to the incumbent f...

Znaczenie mechanizmu naprawy DNA błędnie sparowanych zasad azotowych (MMR w raku piersi

Directory of Open Access Journals (Sweden)

Hanna Romanowicz

2010-04-01

Full Text Available Background: Microsatellite instability (MSI is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR genes lead to replication errors revealed as instability in microsatellite markers. Studieshave shown that breast cancer may be associated with mutations in mismatch repair genes, such as MSH2,MSH3, MSH4, MSH6, MLH1, MLH3, PMS1 and MUTYH. Aim: Results from studies that assayed MMR in sporadic breast cancer are reviewed. Conclusion: Several data suggest that microsatellite instability seems to be a risk factor for breast cancerin subjects belonging to HNPCC (hereditary non-polyposis colorectal cancer families with high incidence of thiscancer and sporadic breast cancer.

Dynamic and Control Analysis of Modular Multi-Parallel Rectifiers (MMR)

DEFF Research Database (Denmark)

Zare, Firuz; Ghosh, Arindam; Davari, Pooya

2017-01-01

This paper presents dynamic analysis of a Modular Multi-Parallel Rectifier (MMR) based on state-space modelling and analysis. The proposed topology is suitable for high power application which can reduce line current harmonics emissions significantly. However, a proper controller is required...... to share and control current through each rectifier. Mathematical analysis and preliminary simulations have been carried out to verify the proposed controller under different operating conditions....

A multifactorial likelihood model for MMR gene variant classification incorporating probabilities based on sequence bioinformatics and tumor characteristics: a report from the Colon Cancer Family Registry.

Science.gov (United States)

Thompson, Bryony A; Goldgar, David E; Paterson, Carol; Clendenning, Mark; Walters, Rhiannon; Arnold, Sven; Parsons, Michael T; Michael D, Walsh; Gallinger, Steven; Haile, Robert W; Hopper, John L; Jenkins, Mark A; Lemarchand, Loic; Lindor, Noralane M; Newcomb, Polly A; Thibodeau, Stephen N; Young, Joanne P; Buchanan, Daniel D; Tavtigian, Sean V; Spurdle, Amanda B

2013-01-01

Mismatch repair (MMR) gene sequence variants of uncertain clinical significance are often identified in suspected Lynch syndrome families, and this constitutes a challenge for both researchers and clinicians. Multifactorial likelihood model approaches provide a quantitative measure of MMR variant pathogenicity, but first require input of likelihood ratios (LRs) for different MMR variation-associated characteristics from appropriate, well-characterized reference datasets. Microsatellite instability (MSI) and somatic BRAF tumor data for unselected colorectal cancer probands of known pathogenic variant status were used to derive LRs for tumor characteristics using the Colon Cancer Family Registry (CFR) resource. These tumor LRs were combined with variant segregation within families, and estimates of prior probability of pathogenicity based on sequence conservation and position, to analyze 44 unclassified variants identified initially in Australasian Colon CFR families. In addition, in vitro splicing analyses were conducted on the subset of variants based on bioinformatic splicing predictions. The LR in favor of pathogenicity was estimated to be ~12-fold for a colorectal tumor with a BRAF mutation-negative MSI-H phenotype. For 31 of the 44 variants, the posterior probabilities of pathogenicity were such that altered clinical management would be indicated. Our findings provide a working multifactorial likelihood model for classification that carefully considers mode of ascertainment for gene testing. © 2012 Wiley Periodicals, Inc.

Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.

Directory of Open Access Journals (Sweden)

Mehdi Shakibaei

Full Text Available OBJECTIVE: Treatment of colorectal cancer (CRC remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC are capable of surviving conventional chemotherapies that permits regeneration of original tumors. Therefore, we investigated the effectiveness of 5-FU and plant polyphenol (curcumin in context of DNA mismatch repair (MMR status and CSC activity in 3D cultures of CRC cells. METHODS: High density 3D cultures of CRC cell lines HCT116, HCT116+ch3 (complemented with chromosome 3 and their corresponding isogenic 5-FU-chemo-resistant derivative clones (HCT116R, HCT116+ch3R were treated with 5-FU either without or with curcumin in time- and dose-dependent assays. RESULTS: Pre-treatment with curcumin significantly enhanced the effect of 5-FU on HCT116R and HCR116+ch3R cells, in contrast to 5-FU alone as evidenced by increased disintegration of colonospheres, enhanced apoptosis and by inhibiting their growth. Curcumin and/or 5-FU strongly affected MMR-deficient CRC cells in high density cultures, however MMR-proficient CRC cells were more sensitive. These effects of curcumin in enhancing chemosensitivity to 5-FU were further supported by its ability to effectively suppress CSC pools as evidenced by decreased number of CSC marker positive cells, highlighting the suitability of this 3D culture model for evaluating CSC marker expression in a close to vivo setting. CONCLUSION: Our results illustrate novel and previously unrecognized effects of curcumin in enhancing chemosensitization to 5-FU-based chemotherapy on DNA MMR-deficient and their chemo-resistant counterparts by targeting the CSC sub-population. (246 words in abstract.

Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.

Science.gov (United States)

Shakibaei, Mehdi; Buhrmann, Constanze; Kraehe, Patricia; Shayan, Parviz; Lueders, Cora; Goel, Ajay

2014-01-01

Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC) are capable of surviving conventional chemotherapies that permits regeneration of original tumors. Therefore, we investigated the effectiveness of 5-FU and plant polyphenol (curcumin) in context of DNA mismatch repair (MMR) status and CSC activity in 3D cultures of CRC cells. High density 3D cultures of CRC cell lines HCT116, HCT116+ch3 (complemented with chromosome 3) and their corresponding isogenic 5-FU-chemo-resistant derivative clones (HCT116R, HCT116+ch3R) were treated with 5-FU either without or with curcumin in time- and dose-dependent assays. Pre-treatment with curcumin significantly enhanced the effect of 5-FU on HCT116R and HCR116+ch3R cells, in contrast to 5-FU alone as evidenced by increased disintegration of colonospheres, enhanced apoptosis and by inhibiting their growth. Curcumin and/or 5-FU strongly affected MMR-deficient CRC cells in high density cultures, however MMR-proficient CRC cells were more sensitive. These effects of curcumin in enhancing chemosensitivity to 5-FU were further supported by its ability to effectively suppress CSC pools as evidenced by decreased number of CSC marker positive cells, highlighting the suitability of this 3D culture model for evaluating CSC marker expression in a close to vivo setting. Our results illustrate novel and previously unrecognized effects of curcumin in enhancing chemosensitization to 5-FU-based chemotherapy on DNA MMR-deficient and their chemo-resistant counterparts by targeting the CSC sub-population. (246 words in abstract).

Contestable Licensing

OpenAIRE

Zvika Neeman; Gerhard O. Orosel

2000-01-01

We analyze a model of repeated franchise bidding for natural monopoly with contestable licensing - a franchisee halds an (exclusive) license to operate a franchise until another rm offers to pay more for it. In a world where quality is observable but not veri able, the simple regulatory scheme we describe combines market-like incentives with regulatory oversight to generate efficient outcomes.

Autism Narratives in Media Coverage of the MMR Vaccine-Autism Controversy under a Crip Futurism Framework.

Science.gov (United States)

Mann, Benjamin W

2018-03-09

While previous studies in health communication have examined online news media regarding autism, there is a lack of research that critically examines how such media representations may stigmatize autism and seeks to eliminate the condition, particularly in the context of the resurging measles, mumps, and rubella (MMR) vaccine-autism controversy. To address this gap in the literature, this study analyzes 153 articles that engage the MMR vaccine-autism controversy from the top 10 online news sources in the U.S. from September 2015 through July 2017. It draws from Kafer's (2013) work in Feminist, Crip, Queer, using a lens of crip futurism to interpret three major narrative themes: a death and survival narrative that purports autism as a worst-case scenario, a societal problem narrative, and a preventative narrative that seeks to eliminate the condition. These themes suggest that online news media narratives about autism surrounding the autism-MMR controversy play into stereotypes about autism, including stigmatization and prioritization of preventive behaviors and cures over supporting the lived experiences of autistic individuals. Continued research on the impact of online media portrayals of autism specifically, and disability in health contexts generally, is called for.

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age

DEFF Research Database (Denmark)

Møller, Pål; Seppälä, Toni; Bernstein, Inge

2017-01-01

BACKGROUND: Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists with respect to cancer risk and survival. OBJECTIVE AND DESIGN......%, duodenum 67%, stomach 61%, bile duct 29%, brain 22% and pancreas 0%. Path_PMS2 carriers had lower risk for cancer. CONCLUSION: Carriers of different path_MMR variants exhibit distinct patterns of cancer risk and survival as they age. Risk estimates for counselling and planning of surveillance and treatment...

Licensing in an international triopoly

Science.gov (United States)

Ferreira, Fernanda A.; Ferreira, Flávio

2011-12-01

We study the effects of entry of two foreign firms on domestic welfare in the presence of licensing, when the incumbent is technologically superior to the entrants. We consider two different situations: (i) the cost-reducing innovation is licensed to both entrants; (ii) the cost-reducing innovation is licensed to just one of the entrants. We analyse three kind of license: (lump-sum) fixed-fee; (per-unit) royalty; and two-part tariff, that is a combination of a fixed-fee and a royalty. We prove that a two part tariff is never an optimal licensing scheme for the incumbent. Moreover, (i) when the technology is licensed to the two entrants, the optimal contract consists of a licensing with only output royalty; and (ii) when the technology is licensed to just one of the entrants, the optimal contract consists of a licensing with only a fixed-fee.

Inequity in Timeliness of MMR Vaccination in Children Living in the Suburbs of Iranian Cities.

Science.gov (United States)

Jadidi, Rahmatollah; Mohammadbeigi, Abolfazl; Mohammadsalehi, Narges; Ansari, Hossein; Ghaderi, Ebrahim

2015-06-01

High coverage of immunization is one of the indicators of good performance of health system but timely vaccination is another indicator which is associated with protective effect of vaccines. The present study aimed at evaluating the inequity in timely vaccination with a focus on inequities in timeliness by gender, birth order, parents' education and place of residence (rural or urban). A historical cohort study was conducted on children of 24-47 months of age who were living in the suburbs of big cities in Iran and were selected through stratified proportional sampling method. Only children who had vaccine cards -i.e. 3610 children -were included in data analysis. The primary outcome was age-appropriate vaccination of MMR1. Inequity was measured by Concentration Index (C) and Relative Index of Inequity (RII). Inequity indexes were calculated according to the mother and father's education, child birth order, child's sex and the family's place of residence at the time of vaccination. The overall on-time MMR1 vaccination was 70% and 54.4% for Iranians and Non-Iranians, respectively. The C index of mother and father's education for timely MMR vaccination was 0.023 and was 0.029 in Iranian children as well as 0.044 and 0.019 for non-Iranians, respectively. The C index according to child order in Iranians and Non-Iranians was 0.025 and C=0.078. With regard to children who lived in cities, the on-time vaccination was 0.36% and 0.29% higher than that in rural areas . In male children it was 0.12% and 0.14% higher than that in female children for Iranians and Non-Iranians, respectively. Timeliness MMR vaccination in Iranian children is higher than that in non-Iranian children. Regarding the existence of differences in timely vaccination rate in all Iranian and Non-Iranian children, no evidence was observed for inequity by focusing on parents' education, birth order, gender or place of residence. So, increasing timeliness of vaccination for enhancing the protective effect

Combination of pegylated IFN-α2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia

DEFF Research Database (Denmark)

Simonsson, Bengt; Gedde-Dahl, Tobias; Markevärn, Berit

2011-01-01

Biologic and clinical observations suggest that combining imatinib with IFN-a may improve treatment outcome in chronic myeloid leukemia (CML). We randomized newly diagnosed chronic-phase CML patients with a low or intermediate Sokal risk score and in imatinib-induced complete hematologic remission......%) discontinued imatinib treatment (1 because of blastic transformation in imatinib arm). In addition, in the combination arm, 34 patients (61%) discontinued Peg-IFN-a2b, most because of toxicity. The MMR rate at 12 months was significantly higher in the imatinib plus Peg-IFN-a2b arm (82%) compared...... with the imatinib monotherapy arm (54%; intention-to-treat, P = .002). The MMR rate increased with the duration of Peg-IFN-a2b treatment ( 12-week MMR rate 91%). Thus, the addition of even relatively short periods of Peg-IFN-a2b to imatinib markedly increased the MMR rate at 12 months...

78 FR 4467 - UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3...

Science.gov (United States)

2013-01-22

... NUCLEAR REGULATORY COMMISSION [Docket No. 52-016; NRC-2008-0250] UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3, Exemption 1.0 Background UniStar Nuclear Energy (UNE), on behalf of Calvert Cliffs Nuclear Project, LLC and UniStar Nuclear Operating Services...

76 FR 81994 - UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit...

Science.gov (United States)

2011-12-29

... NUCLEAR REGULATORY COMMISSION [Docket No. 52-016; NRC-2008-0250] UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit 3; Exemption 1.0 Background: UniStar Nuclear Energy (UNE) submitted to the U.S. Nuclear Regulatory Commission (NRC or the Commission ) a...

76 FR 11522 - In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear...

Science.gov (United States)

2011-03-02

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-029-COL, 52-030-COL] In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear Power Plant, Units 1 and 2... by the Nuclear Regulatory Commission staff in this case. Mr. Dehmel has not previously performed any...

Performance Estimation of Supercritical Co2 Micro Modular Reactor (MMR) for Varying Cooling Air Temperature

International Nuclear Information System (INIS)

Ahn, Yoonhan; Kim, Seong Gu; Cho, Seong Kuk; Lee, Jeong Ik

2015-01-01

A Small Modular Reactor (SMR) receives interests for the various application such as electricity co-generation, small-scale power generation, seawater desalination, district heating and propulsion. As a part of SMR development, supercritical CO2 Micro Modular Reactor (MMR) of 36.2MWth in power is under development by the KAIST research team. To enhance the mobility, the entire system including the power conversion system is designed for the full modularization. Based on the preliminary design, the thermal efficiency is 31.5% when CO2 is sufficiently cooled to the design temperature. A supercritical CO2 MMR is designed to supply electricity to the remote regions. The ambient temperature of the area can influence the compressor inlet temperature as the reactor is cooled with the atmospheric air. To estimate the S-CO2 cycle performance for various environmental conditions, A quasi-static analysis code is developed. For the off design performance of S-CO2 turbomachineries, the experimental result of Sandia National Lab (SNL) is utilized

Changing mobility patterns and road mortality among pre-license teens in a late licensing country : an epidemiological study.

NARCIS (Netherlands)

Twisk, D.A.M. Bos, N.M. Shope, J.T. & Kok, G.

2013-01-01

Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a

Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures.

Science.gov (United States)

Klein, Nicola P; Fireman, Bruce; Yih, W Katherine; Lewis, Edwin; Kulldorff, Martin; Ray, Paula; Baxter, Roger; Hambidge, Simon; Nordin, James; Naleway, Allison; Belongia, Edward A; Lieu, Tracy; Baggs, James; Weintraub, Eric

2010-07-01

In February 2008, we alerted the Advisory Committee on Immunization Practices to preliminary evidence of a twofold increased risk of febrile seizures after the combination measles-mumps-rubella-varicella (MMRV) vaccine when compared with separate measles-mumps-rubella (MMR) and varicella vaccines. Now with data on twice as many vaccine recipients, our goal was to reexamine seizure risk after MMRV vaccine. Using 2000-2008 Vaccine Safety Datalink data, we assessed seizures and fever visits among children aged 12 to 23 months after MMRV and separate MMR + varicella vaccines. We compared seizure risk after MMRV vaccine to that after MMR + varicella vaccines by using Poisson regression as well as with supplementary regressions that incorporated chart-review results and self-controlled analyses. MMRV vaccine recipients (83,107) were compared with recipients of MMR + varicella vaccines (376,354). Seizure and fever significantly clustered 7 to 10 days after vaccination with all measles-containing vaccines but not after varicella vaccination alone. Seizure risk during days 7 to 10 was higher after MMRV than after MMR + varicella vaccination (relative risk: 1.98 [95% confidence interval: 1.43-2.73]). Supplementary analyses yielded similar results. The excess risk for febrile seizures 7 to 10 days after MMRV compared with separate MMR + varicella vaccination was 4.3 per 10,000 doses (95% confidence interval: 2.6-5.6). Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines. Providers who recommend MMRV should communicate to parents that it increases the risk of fever and seizure over that already associated with measles-containing vaccines.

Immunogenicity and safety of a novel MMR vaccine (live, freeze-dried) containing the Edmonston-Zagreb measles strain, the Hoshino mumps strain, and the RA 27/3 rubella strain: Results of a randomized, comparative, active controlled phase III clinical trial.

Science.gov (United States)

Sood, Ashwani; Mitra, Monjori; Joshi, Himanshu Arvind; Nayak, Uma Siddhartha; Siddaiah, Prashanth; Babu, T Ramesh; Mahapatro, Samarendra; Sanmukhani, Jayesh; Gupta, Gaurav; Mittal, Ravindra; Glueck, Reinhard

2017-07-03

This phase III clinical trial was conducted to evaluate the immunogenicity and safety of the single-dose and multi-dose formulations of a novel MMR vaccine (live, freeze-dried) developed by M/s Cadila Healthcare Limited, India (Cadila MMR vaccine), containing the Hoshino mumps strain, compared to that of an existing MMR vaccine (live, freeze-dried) developed by M/s Serum Institute of India Limited, India (Serum MMR vaccine). These two vaccines have similar measles and rubella strains, but different mumps strains (Hoshino in Cadila MMR vaccine, and L-Zagreb in Serum MMR vaccine). Three hundred and twenty-eight subjects of either sex, aged 15-18 months, were randomized in a 2:1 ratio to receive either the Cadila or Serum MMR vaccine. Immunogenicity assessments (IgG antibodies against measles, mumps, and rubella viruses) were done at baseline and 42 d after vaccination. Solicited (local and systemic) and unsolicited adverse events were recorded for up to 42 d following vaccination. The Cadila MMR vaccine was found to be non-inferior to the Serum MMR vaccine in terms of end-of-study proportion of subjects seropositive for anti-measles antibodies (100.0% in both groups), anti-mumps antibodies (94.5% vs. 94.0%), and anti-rubella antibodies (95.5% vs. 91.0%). Both vaccines were well tolerated by all study participants; the most common adverse event reported in both groups was fever, followed by rash. The results of this phase III clinical trial show that the novel Cadila MMR vaccine is non-inferior to the Serum MMR vaccine.

Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity.

Science.gov (United States)

Baris, Hagit N; Barnes-Kedar, Inbal; Toledano, Helen; Halpern, Marisa; Hershkovitz, Dov; Lossos, Alexander; Lerer, Israela; Peretz, Tamar; Kariv, Revital; Cohen, Shlomi; Half, Elizabeth E; Magal, Nurit; Drasinover, Valerie; Wimmer, Katharina; Goldberg, Yael; Bercovich, Dani; Levi, Zohar

2016-03-01

Heterozygous germline mutations in any of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2, cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome conferring a high risk of colorectal, endometrial, and other cancers in adulthood. Offspring of couples where both spouses have LS have a 1:4 risk of inheriting biallelic MMR gene mutations. These cause constitutional MMR deficiency (CMMRD) syndrome, a severe recessively inherited cancer syndrome with a broad tumor spectrum including mainly hematological malignancies, brain tumors, and colon cancer in childhood and adolescence. Many CMMRD children also present with café au lait spots and axillary freckling mimicking neurofibromatosis type 1. We describe our experience in seven CMMRD families demonstrating the role and importance of founder mutations and consanguinity on its prevalence. Clinical presentations included brain tumors, colon cancer, lymphoma, and small bowel cancer. In children from two nonconsanguineous Ashkenazi Jewish (AJ) families, the common Ashkenazi founder mutations were detected; these were homozygous in one family and compound heterozygous in the other. In four consanguineous families of various ancestries, different homozygous mutations were identified. In a nonconsanguineous Caucasus/AJ family, lack of PMS2 was demonstrated in tumor and normal tissues; however, mutations were not identified. CMMRD is rare, but, especially in areas where founder mutations for LS and consanguinity are common, pediatricians should be aware of it since they are the first to encounter these children. Early diagnosis will enable tailored cancer surveillance in the entire family and a discussion regarding prenatal genetic diagnosis. © 2015 Wiley Periodicals, Inc.

A Conceptual Study of Using an Isothermal Compressor on an S-CO{sub 2} Cooled KAIST Micro Modular Reactor (KAIST-MMR)

Energy Technology Data Exchange (ETDEWEB)

Heo, Jin Young; Ahn, Yoonhan; Lee, Jeong Ik [KAIST, Daejeon (Korea, Republic of)

2016-05-15

Although the isothermal compressor technology is not fully matured for commercialization, its potential to reduce the compressor work and the cycle physical size due to the merging of the compressor and the precooler into one turbomachine can be utilized well especially in a concept such as the KAIST-MMR. Future works include optimization of the cycle layout and parameters to enhance performance, calculation of the heat exchanger sizes, and turbomachinery design of components. The development of small modular reactors (SMR) has been gathering attention due to factory manufacturing, but the power system required for a steam cycle in a water-cooled SMR is significantly large. A new concept called the KAIST Micro Modular Reactor (MMR) has been designed previously to make use of the supercritical CO{sub 2} (S-CO{sub 2}) cycle to significantly decrease the size and to improve its cycle efficiency. To further enhance the advantages of the KAIST-MMR concept, the conventional compressor is replaced with an isothermal compressor in the S-CO{sub 2} cycle.

Licensing reform in the USA

International Nuclear Information System (INIS)

1991-01-01

The licensing process for nuclear power plants in the USA is currently in two distinct stages: the issuance of a construction permit followed later by the issuance of an operation license. The ''two-step'' process has come under heavy criticism from the U.S. nuclear industry on the grounds that it causes uncertainty and delays and therefore inhibits new commitments to nuclear power plants. In 1989 the NRC published new regulations for the licensing of nuclear power plants which provide for the issuance of early site permits, safety certifications of standard designs, and combined construction permits and operating licences. The new rule was challenged by intervenors representing antinuclear groups who filed a legal challenge seeking to have the rule set aside on the grounds that it violates the Atomic Energy Act which they allege makes two-step licensing mandatory. In November 1990 the US Court of Appeals upheld the NRC's authority to issue combined licenses. An appeal for a rehearing has been filed. The paper analyses the events and the possible consequences of an adverse court decision. It reviews the options open to the NRC and industry if the court decision is upheld. The possibility of congressional action to amend the Atomic Energy Act is discussed. (author)

License Auctions with Royalty Contracts for (Winners and) Losers

OpenAIRE

Wolfstetter, Elmar; Giebe, Thomas

2007-01-01

This paper revisits the licensing of a non–drastic process innovation by an outside innovator to a Cournot oligopoly. We propose a new mechanism that combines a restrictive license auction with royalty licensing. This mechanism is more profitable than standard license auctions, auctioning royalty contracts, fixed–fee licensing, pure royalty licensing, and two-part tariffs. The key features are that royalty contracts are auctioned and that losers of the auction are granted the option to si...

77 FR 63343 - Biweekly Notice: Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Science.gov (United States)

2012-10-16

... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... for an inoperable diesel generator (DG). A commensurate change is also proposed to extend the maximum... alternating current power source (i.e., a supplemental diesel generator) with the capability to power any E...

77 FR 73684 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Science.gov (United States)

2012-12-11

... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... emergency diesel generator, and the stored lube oil inventory will also continue to require that a 7-day supply be available for each diesel generator. The changes are consistent with NRC-approved Technical...

77 FR 70837 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Science.gov (United States)

2012-11-27

... intervene shall be filed in accordance with the Commission's ``Rules of Practice for Domestic Licensing... request: The proposed change will delete Function 14, SG [Steam Generator] Water Level--Low, Coincident... capability to shut down the reactor when required on Low--Low Steam Generator water level. The ability to...

78 FR 16876 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Science.gov (United States)

2013-03-19

... intervene shall be filed in accordance with the Commission's ``Rules of Practice for Domestic Licensing... proposes to replace the VHS with an onsite diesel generator as the AAC power source providing this... power source (the VHS) with an additional onsite AAC power source (diesel generator). This equipment can...

77 FR 67679 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Science.gov (United States)

2012-11-13

... diesel generator surveillance requirements. Margin of safety is related to the ability of the fission... evaluated; or (3) involve a significant reduction in a margin of safety. The basis for this proposed... accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR Part 2...

78 FR 14126 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Science.gov (United States)

2013-03-04

... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... of the document. The E-Filing system also distributes an email notice that provides access to the... Completion Time has no impact on the consequences of any design basis accident since the consequences of an...

The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study.

Science.gov (United States)

La Torre, Giuseppe; Saulle, Rosella; Unim, Brigid; Meggiolaro, Angela; Barbato, Angelo; Mannocci, Alice; Spadea, Antonietta

2017-08-03

To evaluate the effectiveness of the measles-mumps-rubella (MMR) vaccine in reducing hospitalizations for infectious disease, targeted and not targeted, as well as from respiratory diseases in children in Rome. The cohort was recomposed through record linkage of 2 archives (vaccination register and hospital discharge records. The analysis included 11,004 children. 20.9% did not receive the MMR vaccination, 49% and 30.1% received one and 2 doses. There were no hospitalizations for rubella, 2 for mumps, and 12 for measles. The vaccine was highly protective against measles and mumps hospitalizations (HR = 0.10; 95% CI: 0.03.0.34). Regarding all infectious diseases there were 414 hospitalizations, and the vaccine was protective (HR = 0.29; 95% CI: 0.25 to 0.34). Concerning respiratory diseases, there were 809 admissions (7.4%), and the vaccine was highly protective (HR: 0.18; 95% CI: 0.07 to 0.48). MMR vaccination is effective for the primary prevention of target and not targeted infectious diseases and may also limit hospitalizations for respiratory diseases.

10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N... FOR NUCLEAR POWER PLANTS Pt. 52, App. N Appendix N to Part 52—Standardization of Nuclear Power Plant...

76 FR 79228 - Combined Licenses at William States Lee III Nuclear Station Site, Units 1 and 2; Duke Energy...

Science.gov (United States)

2011-12-21

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-018 and 52-019; NRC-2008-0170] Combined Licenses at William States Lee III Nuclear Station Site, Units 1 and 2; Duke Energy Carolinas, LLC AGENCY: Nuclear.... SUMMARY: Notice is hereby given that the U.S. Nuclear Regulatory Commission (NRC) and the U.S. Army Corps...

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures

OpenAIRE

Shakibaei, Mehdi; Buhrmann, Constanze; Kraehe, Patricia; Shayan, Parviz; Lueders, Cora; Goel, Ajay

2014-01-01

OBJECTIVE: Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC) are capable of surviving conventional chemotherapies that permits regeneration of original tumors. Therefore, we investigated the effectiveness of 5-FU and plant polyphenol (curcumin) in context of DNA mismatch repair (MMR) status and CSC ac...

A BWR licensing experience in the USA

International Nuclear Information System (INIS)

Powers, J.; Ogura, C.; Arai, K.; Thomas, S.; Mookhoek, B.

2015-09-01

The US-Advanced Boiling Water Reactor (A BWR), certified by the United States Nuclear Regulatory Commission (US NRC), is a third generation, evolutionary boiling water reactor design which is the reference for the South Texas Project Units 3 and 4 (STP3-4) Combined License Application (Cola). Nuclear Innovation North America (Nina) is the License Applicant for this new build project, and Toshiba is the selected primary technology contractor. The STP3-4 project has finished the US NRC technical review of the Cola through the final meeting of the Advisory Committee on Reactor Safeguards (ACRS), and the Final Safety Evaluation Report (FSER) is scheduled to be issued by the US NRC in the middle of 2015. The next steps are to support the Mandatory Hearing process, and voting by the NRC commissioners on the motion to grant the Combined License, which is scheduled beginning of 2016 according to US NRC schedule as of March 30, 2015. This paper summarizes the history and progress of the US-A BWR licensing, including the experiences of the Licensee, Nina, and Toshiba as the Epc team worked through the Code of Federal Regulations Title 10 (10-Cfr) Part 52 process, and provides some perspectives on how the related licensing material would also be of value within a 10-Cfr Part 50, two-step process to minimize schedule and financial risks which could arise from ongoing technical developments and regulatory reviews. (Author)

A BWR licensing experience in the USA

Energy Technology Data Exchange (ETDEWEB)

Powers, J.; Ogura, C. [Toshiba America Nuclear Energy, Charlotte, North Carolina (United States); Arai, K. [Toshiba Corporation, Yokohama, Kanagawa (Japan); Thomas, S.; Mookhoek, B., E-mail: jim.powers@toshiba.com [Nuclear Innovation North America, Lake Jackson, Texas (United States)

2015-09-15

The US-Advanced Boiling Water Reactor (A BWR), certified by the United States Nuclear Regulatory Commission (US NRC), is a third generation, evolutionary boiling water reactor design which is the reference for the South Texas Project Units 3 and 4 (STP3-4) Combined License Application (Cola). Nuclear Innovation North America (Nina) is the License Applicant for this new build project, and Toshiba is the selected primary technology contractor. The STP3-4 project has finished the US NRC technical review of the Cola through the final meeting of the Advisory Committee on Reactor Safeguards (ACRS), and the Final Safety Evaluation Report (FSER) is scheduled to be issued by the US NRC in the middle of 2015. The next steps are to support the Mandatory Hearing process, and voting by the NRC commissioners on the motion to grant the Combined License, which is scheduled beginning of 2016 according to US NRC schedule as of March 30, 2015. This paper summarizes the history and progress of the US-A BWR licensing, including the experiences of the Licensee, Nina, and Toshiba as the Epc team worked through the Code of Federal Regulations Title 10 (10-Cfr) Part 52 process, and provides some perspectives on how the related licensing material would also be of value within a 10-Cfr Part 50, two-step process to minimize schedule and financial risks which could arise from ongoing technical developments and regulatory reviews. (Author)

Current status of the PBMR licensing project

International Nuclear Information System (INIS)

Mysen, A.; Clapisson, G.A.; Metcalf, P.E.

2000-01-01

The CNS is currently reviewing the PBMR conceptual design from a licensibility point of view. The PBMR concept is based on a High Temperature Gas Cooled Reactor - pebble bed reactor type. It is anticipated that the PBMR design will rely on inherent safety characteristics to contain fission products within fuel over the full range of design basis events. This feature combined with the high temperature integrity of the fuel and structural graphite, allows the safe use of a high coolant temperature, which allows consideration of the future development of this reactor for non-electrical applications of nuclear heat for industrial use. The CNS licensing approach requires that the licensing and design basis of the plant should respect prevailing international norms and practices and that a quantitative risk assessment should demonstrate compliance with the CNS fundamental safety standards. The first stage of the licensing process is now ongoing; this is a pre-application phase, which will result in a statement on licensibility being issued. Identification of the specific documentation requirements and information needed is required across every step of the licensing process. Top level regulatory requirements have been established for the PBMR. They include the CNS fundamental safety standard and basic licensing criteria, which describes requirements on licensees of nuclear installations regarding risk assessment and compliance with the safety criteria and define classification of licensing basis events. (author)

Partner Selection in Technological Licensing Agreements

DEFF Research Database (Denmark)

Laursen, Keld; Trombini, Giulia

This paper investigates the matching of seller and buyer firms in the market for technology licensing. By combining organizational learning theory with the industrial organization approach, we propose a matching model in which technological similarities in terms of relatedness and familiarity work...... that is technologically unrelated, ex ante familiarity with the licensors’ technology is required. We contend also that there is interdependence between technological learning and market competition: if partners are in the same product markets, the likelihood of technology license contractual partnerships decreases...

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis

OpenAIRE

Avdievich, Elena; Reiss, Cora; Scherer, Stefan J.; Zhang, Yongwei; Maier, Sandra M.; Jin, Bo; Hou, Harry; Rosenwald, Andreas; Riedmiller, Hubertus; Kucherlapati, Raju; Cohen, Paula E.; Edelmann, Winfried; Kneitz, Burkhard

2008-01-01

Mutations in the human DNA mismatch repair (MMR) gene MLH1 are associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome, HNPCC) and a significant proportion of sporadic colorectal cancer. The inactivation of MLH1 results in the accumulation of somatic mutations in the genome of tumor cells and resistance to the genotoxic effects of a variety of DNA damaging agents. To study the effect of MLH1 missense mutations on cancer susceptibility, we generated a mouse line carrying the ...

ITER licensing

International Nuclear Information System (INIS)

Gordon, C.W.

2005-01-01

ITER was fortunate to have four countries interested in ITER siting to the point where licensing discussions were initiated. This experience uncovered the challenges of licensing a first of a kind, fusion machine under different licensing regimes and helped prepare the way for the site specific licensing process. These initial steps in licensing ITER have allowed for refining the safety case and provide confidence that the design and safety approach will be licensable. With site-specific licensing underway, the necessary regulatory submissions have been defined and are well on the way to being completed. Of course, there is still work to be done and details to be sorted out. However, the informal international discussions to bring both the proponent and regulatory authority up to a common level of understanding have laid the foundation for a licensing process that should proceed smoothly. This paper provides observations from the perspective of the International Team. (author)

Mutual interference on the immune response to yellow fever vaccine and a combined vaccine against measles, mumps and rubella.

Science.gov (United States)

Nascimento Silva, Juliana Romualdo; Camacho, Luiz Antonio B; Siqueira, Marilda M; Freire, Marcos de Silva; Castro, Yvone P; Maia, Maria de Lourdes S; Yamamura, Anna Maya Y; Martins, Reinaldo M; Leal, Maria de Luz F

2011-08-26

A randomized trial was conducted to assess the immunogenicity and reactogenicity of yellow fever vaccines (YFV) given either simultaneously in separate injections, or 30 days or more after a combined measles-mumps-rubella (MMR) vaccine. Volunteers were also randomized to YFV produced from 17DD and WHO-17D-213 substrains. The study group comprised 1769 healthy 12-month-old children brought to health care centers in Brasilia for routine vaccination. The reactogenicity was of the type and frequency expected for the vaccines and no severe adverse event was associated to either vaccine. Seroconversion and seropositivity 30 days or more after vaccination against yellow fever was similar across groups defined by YFV substrain. Subjects injected YFV and MMR simultaneously had lower seroconversion rates--90% for rubella, 70% for yellow fever and 61% for mumps--compared with those vaccinated 30 days apart--97% for rubella, 87% for yellow fever and 71% for mumps. Seroconversion rates for measles were higher than 98% in both comparison groups. Geometric mean titers for rubella and for yellow fever were approximately three times higher among those who got the vaccines 30 days apart. For measles and mumps antibodies GMTs were similar across groups. MMR's interference in immune response of YFV and YFV's interference in immune response of rubella and mumps components of MMR had never been reported before but are consistent with previous observations from other live vaccines. These results may affect the recommendations regarding primary vaccination with yellow fever vaccine and MMR. Copyright © 2011 Elsevier Ltd. All rights reserved.

U.S. licensing process and ABWR certification

International Nuclear Information System (INIS)

Quirk, J.F.; Williams, W.A.

1996-01-01

Part 50 of Title 10 of the Code of Federal Regulation (CFR) establishes a two-step licensing process by which the U.S. Nuclear Regulatory Committee (NRC) authorizes nuclear reactor plant construction through issuance of a construction permit and authorizes operation by issuance of an operating license. At each stage, the NRC Staff conducts technical reviews and there is potential for public hearings. In 1989, the NRC issued a new, simplified licensing process: Part 52. The purpose of the Part 52 licensing process is to provide a regulatory framework that brings about earlier resolution of licensing issues. Because issues are not resolved early in the Part 50 licensing process, approval of an operating license is not assured until after a significant investment has been made in the plant. Part 52 increases the stability and certainty of the licensing process by providing for the early resolution of safety and environmental issues. The Part 52 licensing process features (1) early site permits, (2) design certification, and (3) combined construction permit and operating licenses. As part of the U.S. Advanced Light Water Reactor (ALWR) Program to revitalize the nuclear option through the integration of government/utility/industry efforts, GE undertook the role of applying for certification for its latest product line, the Advanced Boiling Water Reactor (ABWR), under the U.S. ABWR certification program. The ABWR design is an essentially complete plant. Initial application for design certification was in 1987 under Part 50. GE reapplied in late 1991 under the newly promulgated Part 52. Following seven years of intensive interactions with the NRC and ACRS, GE was awarded the first Final Design Approval (FDA) under Part 52. The Commission initiated rulemaking by publishing the proposed ABWR Certification Rule in the Federal Register in early 1995. Certification is anticipated mid-1996. (J.P.N.)

Using electronic mail to improve MMR uptake amongst third level students.

LENUS (Irish Health Repository)

Cooney, F

2010-03-01

This study assessed the usefulness of email in informing third level students about special MMR clinics being provided on campus during a mumps outbreak in the North West of Ireland. Email messages were sent directly to students, informing them of the clinics, inviting them to make a clinic appointment by email and providing details of walk-in clinics. At the clinics, all 177 attendees were asked to fill out a questionnaire and the response rate was 89% (n=158). Regarding the main sources of information about the vaccination clinics, email was selected by 117 (74%) students, word-of-mouth by 27 (17%), posters\\/leaflets by 8 (5%), and other sources by 6 (4%). Use of email as a source of information was rated as very good\\/excellent by 115 (73%), as good by 35 (22%) and poor\\/fair by 8 (5%). This study demonstrates that email is a useful and acceptable way of informing third level students about immunisation clinics in an outbreak situation.

Using electronic mail to improve MMR uptake amongst third level students.

Science.gov (United States)

Cooney, F; Ryan, A; Schinaia, N; Breslin, A

2010-03-01

This study assessed the usefulness of email in informing third level students about special MMR clinics being provided on campus during a mumps outbreak in the North West of Ireland. Email messages were sent directly to students, informing them of the clinics, inviting them to make a clinic appointment by email and providing details of walk-in clinics. At the clinics, all 177 attendees were asked to fill out a questionnaire and the response rate was 89% (n=158). Regarding the main sources of information about the vaccination clinics, email was selected by 117 (74%) students, word-of-mouth by 27 (17%), posters/leaflets by 8 (5%), and other sources by 6 (4%). Use of email as a source of information was rated as very good/excellent by 115 (73%), as good by 35 (22%) and poor/fair by 8 (5%). This study demonstrates that email is a useful and acceptable way of informing third level students about immunisation clinics in an outbreak situation.

Chinese License Plates Recognition Method Based on A Robust and Efficient Feature Extraction and BPNN Algorithm

Science.gov (United States)

Zhang, Ming; Xie, Fei; Zhao, Jing; Sun, Rui; Zhang, Lei; Zhang, Yue

2018-04-01

The prosperity of license plate recognition technology has made great contribution to the development of Intelligent Transport System (ITS). In this paper, a robust and efficient license plate recognition method is proposed which is based on a combined feature extraction model and BPNN (Back Propagation Neural Network) algorithm. Firstly, the candidate region of the license plate detection and segmentation method is developed. Secondly, a new feature extraction model is designed considering three sets of features combination. Thirdly, the license plates classification and recognition method using the combined feature model and BPNN algorithm is presented. Finally, the experimental results indicate that the license plate segmentation and recognition both can be achieved effectively by the proposed algorithm. Compared with three traditional methods, the recognition accuracy of the proposed method has increased to 95.7% and the consuming time has decreased to 51.4ms.

Licensing reform: a case study in public participation in the nuclear field

International Nuclear Information System (INIS)

Nordlinger, M.S.

1993-01-01

Political process and legal procedures join to accord the public a significant role in nuclear energy policy decision-making in the United States. We changed the two-stage license process in a combined license process with no separation between the construction and operating license, the policy statement requests public comment, allowing days for responses. It is a middle way between information and taking part in decision

AP1000R licensing and deployment in the United States

International Nuclear Information System (INIS)

Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L.

2012-01-01

In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing actions directed

License renewal

International Nuclear Information System (INIS)

Newberry, S.

1993-01-01

This article gives an overview of the process of license renewal for nuclear power plants. It explains what is meant by license renewal, the significance of license renewal, and goes over key elements involved in the process of license renewal. Those key elements are NRC requirements embodied in 10 CFR Part 54 (Reactor Safety) and 10 CFR Part 51 (Environmental Issues). In addition Industry Reports must be developed and reviewed. License renewal is essentially the process of applying for a 20 year extension to the original 40 year operating license granted for the plant. This is a very long term process, which involves a lot of preparation, and compliance with regulatory rules and guidelines. In general it is a process which is expected to begin when plants reach an operating lifetime of 20 years. It has provisions for allowing the public to become involved in the review process

Licensing process for future applications of advanced-design nuclear reactors

International Nuclear Information System (INIS)

Miller, C.L.

1990-01-01

The existing 10CFR50 two-step licensing process in the Code of Federal Regulations can continue to be a viable licensing vehicle for future applications, at least for the near future. The US Nuclear Regulatory Commission (NRC) Commissioners and staff, the public, and the utilities (along with supporting architect/engineers and nuclear steam supply system vendors) have a vast body of experience and knowledge of the existing part 50 licensing process. All these participants are familiar with their respective roles in this process, and history shows this process to be a workable licensing vehicle. Nevertheless, the use of 10CFR52 should be encouraged for future applications. This proposed new rule is intended to achieve the early resolution of licensing issues, to reduce the complexity and uncertainty of the licensing process, and enhance the safety and reliability of nuclear power plants. Part 52's overall purpose is to improve reactor safety and streamline the licensing process by encouraging the use of standard reactor designs and by allowing the early resolution of site environmental and reactor safety issues. The public should be afforded an earlier entry into the licensing process as a result of design certification rulemaking process and combined construction permit/operating license hearings

Improvement suggestions on license extension management for civil nuclear safety equipment activities

International Nuclear Information System (INIS)

Sun Xingjian; Liu Hongji; Han Guoli; Jia Fengcai

2013-01-01

Based on the concepts of Clear Requirements, Comprehensive Review, Objective Assessment, Dynamic Management, this paper gives improvement suggestions on license extension management for civil nuclear safety equipment design, manufacture, installation and non-destructive examination activities, which include establishing a relatively unified license extension review standard, combining multi-views and close linking license review and supervision, full utilizing the daily supervision and inspection results, as well as further improving motivation and elimination mechanism. (authors)

An evaluation of the adverse reaction potential of three measles-mumps-rubella combination vaccines

Directory of Open Access Journals (Sweden)

Santos Boaventura Antônio dos

2002-01-01

Full Text Available Objective. To compare the incidence of adverse events following the administration of three commercially available measles-mumps-rubella (MMR combination vaccines. Methods. A randomized double-blind clinical trial was performed in 1996 that involved a total of 10 142 students 6-12 years of age in the state of Rio Grande do Sul, in Brazil. An MMR vaccine containing the Edmonston-Zagreb, Leningrad-Zagreb, and RA 27/3 strains ("vaccine A" was administered to 2 226 students (21.9% of the total; an MMR vaccine with the Moraten, Jeryl Lynn, and Wistar 27/3 strains ("vaccine B" was administered to 2 216 children (21.8%; and an MMR vaccine containing the Schwartz, Urabe AM-9, and Wistar 27/3 strains ("vaccine C" was given to 2 179 students (21.5%. A control group of 3 521 students (34.7% was not vaccinated. Both the vaccinated subjects and the control subjects were followed daily for 30 days to detect any clinical manifestations. Results. Adverse events were more frequent in the vaccinated children than in the control group (P < 0.01. In terms of causing parotitis, vaccine A had a relative risk (RR of 5.72 (95% confidence interval (CI = 3.11-10.54 when compared with vaccine B, and an RR of 2.33 (95% CI = 1.52-3.58 when compared with vaccine C. Vaccine A was also associated with an increased risk of lymphadenopathy when compared with vaccine B (RR = 3.11; 95% CI = 1.78-5.45 and with vaccine C (RR = 2.22; 95% CI = 1.35-3.66. Vaccine C was associated with an increased risk of parotitis when compared with vaccine B (RR = 2.46; 95% CI = 1.26-4.80. Three cases of aseptic meningitis were detected among the children in the study group, but only one case of vaccine-related aseptic meningitis was identified, among the children receiving vaccine A. Conclusions. The three MMR vaccines that we studied are associated with different risks of adverse events. We found vaccine A to cause more reactions than the two other vaccines, especially vaccine B. In addition

Safety and Immunogenicity of Coadministering a Combined Meningococcal Serogroup C and Haemophilus influenzae Type b Conjugate Vaccine with 7-Valent Pneumococcal Conjugate Vaccine and Measles, Mumps, and Rubella Vaccine at 12 Months of Age ▿

OpenAIRE

Miller, Elizabeth; Andrews, Nick; Waight, Pauline; Findlow, Helen; Ashton, Lindsey; England, Anna; Stanford, Elaine; Matheson, Mary; Southern, Joanna; Sheasby, Elizabeth; Goldblatt, David; Borrow, Ray

2010-01-01

The coadministration of the combined meningococcal serogroup C conjugate (MCC)/Haemophilus influenzae type b (Hib) vaccine with pneumococcal conjugate vaccine (PCV7) and measles, mumps, and rubella (MMR) vaccine at 12 months of age was investigated to assess the safety and immunogenicity of this regimen compared with separate administration of the conjugate vaccines. Children were randomized to receive MCC/Hib vaccine alone followed 1 month later by PCV7 with MMR vaccine or to receive all thr...

Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes

DEFF Research Database (Denmark)

Magnusson, S.; Borg, A.; Kristoffersson, U.

2008-01-01

The contribution of hereditary factors for development of childhood tumors is limited to some few known syndromes associated with predominance of tumors in childhood. Occurrence of childhood tumors in hereditary cancer syndromes such as BRCA1/2 associated breast and ovarian cancer, DNA-mismatch r......-mismatch repair (MMR) genes associated hereditary non polyposis colorectal cancer and CDKN2A associated familial malignant melanoma are very little studied. Herein we report the prevalence of childhood tumors (diagnosed...

Mixed-Methods Design in Biology Education Research: Approach and Uses.

Science.gov (United States)

Warfa, Abdi-Rizak M

Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both quantitative and qualitative inquiries. Specifically, the paper provides an overview of mixed-methods design typologies most relevant in biology education research. It also discusses common methodological issues that may arise in mixed-methods studies and ways to address them. The paper concludes with recommendations on how to report and write about MMR. © 2016 L. A.-R. M. Warfa. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

License renewal process

International Nuclear Information System (INIS)

Fable, D.; Prah, M.; Vrankic, K.; Lebegner, J.

2004-01-01

The purpose of this paper is to provide information about license renewal process, as defined by Nuclear Regulatory Commission (NRC). The Atomic Energy Act and NRC regulations limit commercial power reactor licenses to an initial 40 years but also permit such licenses to be renewed. This original 40-year term for reactor licenses was based on economic and antitrust considerations not on limitations of nuclear technology. Due to this selected time period; however, some structures and components may have been engineered on the basis of an expected 40-year service life. The NRC has established a timely license renewal process and clear requirements codified in 10 CFR Part 51 and 10 CFR Part 54, that are needed to assure safe plant operation for extended plant life. The timely renewal of licenses for an additional 20 years, where appropriate to renew them, may be important to ensuring an adequate energy supply during the first half of the 21st Century. License renewal rests on the determination that currently operating plants continue to maintain adequate levels of safety, and over the plant's life, this level has been enhanced through maintenance of the licensing bases, with appropriate adjustments to address new information from industry operating experience. Additionally, NRC activities have provided ongoing assurance that the licensing bases will continue to provide an acceptable level of safety. This paper provides additional discussion of license renewal costs, as one of key elements in evaluation of license renewal justifiability. Including structure of costs, approximately value and two different approaches, conservative and typical. Current status and position of Nuclear Power Plant Krsko, related to license renewal process, will be briefly presented in this paper. NPP Krsko is designed based on NRC Regulations, so requirements from 10 CFR 51, and 10 CFR 54, are applicable to NPP Krsko, as well. Finally, this paper will give an overview of current status of

NUPLEX Licensing Subcommittee

International Nuclear Information System (INIS)

Edwards, D.W.; Allen, S.R.

1988-01-01

The NUPLEX Licensing Subcommittee was organized to seek a formal license renewal mechanism that institutionalizes the current licensing basis and consequent level of safety of a plant as the legitimate standard for acceptance and approval of an application for extended operation. Along with defining the most workable approach to and scope of review for license renewal, this paper explains the reasons why a regulatory framework is needed by the early 1990s. The initial results of development work on two key issues, licensing criteria and hearing process, are also presented. at this point six potential license renewal criteria have emerged: evaluation of existing monitoring/maintenance programs, revalidation of current licensing basis, conformance to special regulations, evaluation to a safety goal, plant performance history, and environmental assessment. The work on a hearing process has led to the development of two models for future consideration: hybrid legislative and hybrid adjudicatory

Licensing of New Nuclear Power Plants in Canada

International Nuclear Information System (INIS)

Schwarz, Garry; Miller, Doug

2011-01-01

The regulatory process for new power plant licensing in Canada, from receipt of the initial application to commercial operation, can be divided into three phases: - Environmental Assessment (EA) and License to Prepare Site; - License to Construct; and - License to Operate. The Nuclear Safety and Control Act (NSCA) does not have provisions for combined licenses for site preparation, construction, or operation. Separate licenses must, therefore, be granted for each phase, and would be issued in sequence. However, applications to prepare a site, to construct and to operate a new nuclear power plant could be assessed in parallel. The total duration from the application for the License to Prepare Site to the issuance of the License to Operate (which is a prerequisite for first fuel load) has been established as 9 years subject to certain factors. To help facilitate this timeline, the CNSC has undertaken an aggressive program of documenting regulatory practices, requirements and guidance to assist applicants in submitting complete applications. Working level procedures to assist CNSC staff in their review of submissions are also under development. Extensive program and project management has been introduced to ensure that timelines will be achieved. In parallel with the above activities, regulatory oversight measures to be employed during site preparation activities and plant construction and commissioning are also being developed. On the international front, the CNSC is participating in the MDEP program to leverage the resources and knowledge of other national regulatory authorities in reviews the CNSC is undertaking. The CNSC also participates in IAEA and other international activities to utilize/adapt international practices as appropriate in Canada. (authors)

Radiometric calibration of the reflective bands of NS001-Thematic Mapper Simulator (TMS) and modular multispectral radiometers (MMR)

Science.gov (United States)

Markham, Brian L.; Wood, Frank M., Jr.; Ahmad, Suraiya P.

1988-01-01

The NS001 Thematic Mapper Simulator scanner (TMS) and several modular multispectral radiometers (MMRs) are among the primary instruments used in the First ISLSCP (International Satellite Land Surface Climatology Project) Field Experiment (FIFE). The NS001 has a continuously variable gain setting. Calibration of the NS001 data is influenced by drift in the dark current level of up to six counts during a mirror scan at typical gain settings. The MMR instruments are being used in their 1 deg FOV configuration on the helicopter and 15 deg FOV on the ground.

A Malaysian Vehicle License Plate Localization and Recognition System

Directory of Open Access Journals (Sweden)

Ganapathy Velappa

2008-02-01

Full Text Available Technological intelligence is a highly sought after commodity even in traffic-based systems. These intelligent systems do not only help in traffic monitoring but also in commuter safety, law enforcement and commercial applications. In this paper, a license plate localization and recognition system for vehicles in Malaysia is proposed. This system is developed based on digital images and can be easily applied to commercial car park systems for the use of documenting access of parking services, secure usage of parking houses and also to prevent car theft issues. The proposed license plate localization algorithm is based on a combination of morphological processes with a modified Hough Transform approach and the recognition of the license plates is achieved by the implementation of the feed-forward backpropagation artificial neural network. Experimental results show an average of 95% successful license plate localization and recognition in a total of 589 images captured from a complex outdoor environment.

To License or Not to License Remanufacturing Business?

Directory of Open Access Journals (Sweden)

Zu-Jun Ma

2018-01-01

Full Text Available Many original equipment manufacturers (OEMs face the choice of whether to license an independent remanufacturer (IR to remanufacture their used products. In this paper, we develop closed-loop supply chain models with licensed and unlicensed remanufacturing operations to analyze the competition and cooperation between an OEM and an IR. The OEM sells new products and collects used products through trade-ins, while the IR intercepts the OEM’s cores to produce remanufactured products and sell them in the same market. We derive optimal decisions for each of the two types of firms in licensed and unlicensed remanufacturing scenarios and identify conditions under which the OEM and the IR would be most likely to cooperate with each other in implementing remanufacturing. The results show although it is beneficial for an OEM to license an IR to remanufacture its cores, it is not always necessary for an IR to accept OEM’s authorization. Moreover, we contrast the result for licensed remanufacturing scenario in the decentralized system with that in the centrally coordinated system to quantify potential inefficiency resulting from decentralization of decision making.

Technology licensing in China

DEFF Research Database (Denmark)

Wang, Yuandi; Li-Ying, Jason; Chen, Jin

2015-01-01

We explore the landscape of technology licensing among Chinese entities in the period 2000–12, using a unique database on technological licensing from the State Intellectual Property Office of China. We find that: first, among Chinese licensee organizations, firms have dominated in terms...... of the number of licensed technologies; second, the geographical distribution of licensed technologies among the provinces has gradually reached a new quantitative balance; third, utility models are the most popular technologies to be licensed and the majority of technology licensing in China has been between...... Chinese entities, and most transactions have been local within provinces; and finally, Chinese firms have gradually in-licensed newer and newer technologies, but the technologies in-licensed from foreign sources are by no means state-of-the-art. We make several suggestions for innovation policy...

AP1000{sup R} licensing and deployment in the United States

Energy Technology Data Exchange (ETDEWEB)

Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L. [Westinghouse Electric Company LLC, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

2012-07-01

In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing

ICAM (Conceptual Design for Computer-Integrated Manufacturing. Volume 2. Part 6. Task B - Establishment of the Factory of the Future Conceptual Framework Conceptual Framework Document, (MMR)

Science.gov (United States)

1984-06-29

to an area where the chips may be accumulated for recycle or destroyed. This subsystem also involves cleaning and recycling of fluids. o Tool...information and trivia . 5-28 MMR110512000 10 February 1984 Thus, managers interacting with an elementary data processinq system often become

Licensing process in Finland

International Nuclear Information System (INIS)

Tiippana, Petteri

2011-01-01

In accordance with the Nuclear Energy Act, the use of nuclear energy constitutes operations subject to license. The licensing process and conditions for granting a license is defined in the legislation. The licenses are applied from and granted by the Government. This paper discusses briefly the licensing process in Finland and also the roles and responsibilities of main stakeholders in licensing. Licensing of a nuclear power plant in Finland has three steps. The first step is the Decision in Principle (DiP). Goal of DiP is to decide whether using nuclear power is for the overall good for the Finnish society. The second step is Construction License (CL) and the goal of CL phase is to determine whether the design of the proposed plant is safe and that the participating organisations are capable of constructing the plant to meet safety goals. The third step is the Operating License (OL) and the goal of the OL phase is to determine whether the plant operates safely and licensee is capable to operate the plant safely. Main stakeholders in the licensing process in Finland are the utility (licensee) interested in using nuclear power in Finland, Ministry of Employment and the Economy (MEE), Government, Parliament, STUK, the municipality siting the plant and the general public. Government grants all licenses, and Parliament has to ratify Government's Decision in Principle. STUK has to assess the safety of the license applications in each step and give statement to the Ministry. Municipality has to agree to site the plant. Both STUK and the municipality have a veto right in the licensing process

Distinct Clinicopathological Patterns of Mismatch Repair Status in Colorectal Cancer Stratified by KRAS Mutations.

Directory of Open Access Journals (Sweden)

Wenbin Li

Full Text Available In sporadic colorectal cancer (CRC, the BRAFV600E mutation is associated with deficient mismatch repair (MMR status and inversely associated with to KRAS mutations. In contrast to deficient MMR (dMMR CRC, data on the presence of KRAS oncogenic mutations in proficient MMR (pMMR CRC and their relationship with tumor progression are scarce. We therefore examined the MMR status in combination with KRAS mutations in 913 Chinese patients and correlated the findings obtained with clinical and pathological features. The MMR status was determined based on detection of MLH1, MSH2, MSH6 and PMS2 expression. KRAS mutation and dMMR status were detected in 36.9% and 7.5% of cases, respectively. Four subtypes were determined by MMR and KRAS mutation status: KRAS (+/pMMR (34.0%, KRAS (+/dMMR (2.9%, KRAS (-/pMMR (58.5% and KRAS (-/dMMR (4.6%. A higher percentage of pMMR tumors with KRAS mutation were most likely to be female (49.0%, proximal located (45.5%, a mucinous histology (38.4%, and to have increased lymph node metastasis (60.3%, compared with pMMR tumors without BRAFV600E and KRAS mutations (36.0%, 29.3%, 29.4% and 50.7%, respectively; all P < 0.01. To the contrary, compared with those with KRAS(-/dMMR tumors, patients with KRAS(+/dMMR tumors demonstrated no statistically significant differences in gender, tumor location, pT depth of invasion, lymph node metastasis, pTNM stage, and histologic grade. This study revealed that specific epidemiologic and clinicopathologic characteristics are associated with MMR status stratified by KRAS mutation. Knowledge of MMR and KRAS mutation status may enhance molecular pathologic staging of CRC patients and metastatic progression in CRC can be estimated based on the combination of these biomarkers.

Libraries and licensing

Directory of Open Access Journals (Sweden)

Maja Žumer

2001-01-01

Full Text Available In the mid 90s, the abundance of various electronic publications exposed libraries to the problems of licensing electronic content. Various licensing principles have been prepared recently to help libraries in the process; it can be said that in general, the knowledge of licensing issues has improved in libraries of all types. Libraries form consortia in order to gain stronger negotiating positions and obtain better conditions.In the article, new licensing principles are presented in more detail, as well as some domestic and foreign experiences with consortia forming.

Development regulation regarding with licensing of nuclear installation

International Nuclear Information System (INIS)

Bambang Riyono; Yudi Pramono; Dahlia Cakrawati Sinaga

2011-01-01

Provisions of Article 17 paragraph (3) of Law Number 10 Year 1997 on Nuclear cleary mandates for the establishment of government regulations (GR) on Nuclear licensing containing the requirements and procedure, both from the standpoint of their utilization and installation. To use has been rising GR No.29 Year 2008 on the Use of Ionizing Radiation Sources and Nuclear Materials, while for the installation has been published PP No.43 Year 2006 on Nuclear Reactor Licensing, and BAPETEN Chairman Decree No.3 Year 2006 on Non-reactor Nuclear Installation Licensing. Based on the background of the preparation of both the aforementioned are just regulate the reactor and utilization, not yet fully meet the mandate of Article 17 paragraph (3) of Law No.10 of 1997 on Nuclear, including other nuclear installations. For these reasons, it initiated the need for a separate regulation containing provisions concerning licensing of non-reactor nuclear installations. On the other side from the understanding the legal aspects and interpretations of the Law No.10 of 2004 on the Establishment Regulation Legislation, should be in single mandate of Article 17 paragraph (3) of Law No.10 of 1997 on Nuclear would only produce one of the requirements and procedure for the use or installation, or a maximum of two (2) GR related licensing the use and installation. This is encourages conducted the assessing or studies related to how possible it is according to the legal aspect is justified to combine in one Nuclear licensing regulations regarding both the use and installation, by looking at the complexity of installation and wide scope of utilization of nuclear energy in Indonesia. The results of this paper is expected to provide input in the preparation of GR on licensing of nuclear installations. (author)

Reactor licensing

International Nuclear Information System (INIS)

Harvie, J.D.

2002-01-01

This presentation discusses reactor licensing and includes the legislative basis for licensing, other relevant legislation , the purpose of the Nuclear Safety and Control Act, important regulations, regulatory document, policies, and standards. It also discusses the role of the CNSC, its mandate and safety philosophy

TumorNext-Lynch-MMR: a comprehensive next generation sequencing assay for the detection of germline and somatic mutations in genes associated with mismatch repair deficiency and Lynch syndrome.

Science.gov (United States)

Gray, Phillip N; Tsai, Pei; Chen, Daniel; Wu, Sitao; Hoo, Jayne; Mu, Wenbo; Li, Bing; Vuong, Huy; Lu, Hsiao-Mei; Batth, Navanjot; Willett, Sara; Uyeda, Lisa; Shah, Swati; Gau, Chia-Ling; Umali, Monalyn; Espenschied, Carin; Janicek, Mike; Brown, Sandra; Margileth, David; Dobrea, Lavinia; Wagman, Lawrence; Rana, Huma; Hall, Michael J; Ross, Theodora; Terdiman, Jonathan; Cullinane, Carey; Ries, Savita; Totten, Ellen; Elliott, Aaron M

2018-04-17

The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can result in an extended time to diagnosis while depleting precious tumor specimens. Here we describe the analytical validation of a custom probe-based NGS tumor panel, TumorNext-Lynch-MMR, which generates a comprehensive genetic profile of both germline and somatic mutations that can accelerate and streamline the time to diagnosis and preserve specimen. TumorNext-Lynch-MMR can detect single nucleotide variants, small insertions and deletions in 39 genes that are frequently mutated in Lynch syndrome and colorectal cancer. Moreover, the panel provides microsatellite instability status and detects loss of heterozygosity in the five Lynch genes; MSH2 , MSH6 , MLH1 , PMS2 and EPCAM . Clinical cases are described that highlight the assays ability to differentiate between somatic and germline mutations, precisely classify variants and resolve discordant cases.

Nuclear reactor operator licensing

International Nuclear Information System (INIS)

Bursey, R.J.

1978-01-01

The Atomic Energy Act of 1954, which was amended in 1974 by the Energy Reorganization Act, established the requirement that individuals who had the responsibility of operating the reactors in nuclear power plants must be licensed. Section 107 of the act states ''the Commission shall (1) prescribe uniform conditions for licensing individuals; (2) determine the qualifications of such individuals; and (3) issue licenses to such individuals in such form as the Commission may prescribe.'' The article discusses the types of licenses, the selection and training of individuals, and the administration of the Nuclear Regulatory Commission licensing examinations

Operator licensing examiner standards

International Nuclear Information System (INIS)

1987-05-01

The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

Changing mobility patterns and road mortality among pre-license teens in a late licensing country: an epidemiological study.

Science.gov (United States)

Twisk, Divera; Bos, Niels; Shope, Jean T; Kok, Gerjo

2013-04-11

Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a high injury risk, such as bicycles and mopeds, b) inexperience, and c) teens' developmental stage, known to be associated with risk taking and novelty seeking, especially among males. To explore the magnitude and nature of pre-license road risk, this study analysed epidemiological data from the Netherlands, and hypothesized that in this late licensing country, 'independent travel' and the use of riskier modes of transport increase among pre-license teens 10 to 17 years of age, resulting in higher fatality rates, with 'experience' and 'gender' as risk modifying factors. National travel and fatality data of pre-license adolescents in the Netherlands were analysed by traffic role (cyclist, pedestrian, car passenger and moped rider), and compared to a younger age group (0-9 years) and an older age group (18+ years). The study of travel data showed that teens migrate from being car occupants to being users of riskier modes of transport, specifically bicycles and mopeds. This migration resulted in a strong rise in road fatalities, illustrating the importance of mobility patterns for understanding changes in road fatalities in this age group. The data further suggested a protective role of early cycle experience for young adolescent cyclists, particularly for young males. But further study into the underlying mechanism is needed to confirm this relationship. Moped risk was extremely high, especially among young males, and even higher than that of young male car drivers. The study confirmed the importance of changes in mobility patterns for understanding the rising road mortality when youngsters enter into their teens. The focus on fatalities has led to an underestimation of the

Dilemma Program MDGS in Maternal Mortality (MMR and Infant Mortality (IMR Reduction through Jampersal in the District Tuban

Directory of Open Access Journals (Sweden)

M. Amir. HT

2014-03-01

Full Text Available This study is an implementation program designed Jampersal Mixing Methods approach which is a qualitative study, guided by quantitative figures, to examine in depth a phenomenon that exists in society by not manipulate variables (ex post facto, concerning the events that have been occurred, associated with the present condition of the Jampersal users who switch to JKN implementation managed by BPJS since the beginning of 2014. The goal is to examine the implementation Jampersal program, whether the program is to reach the target with existing funds, as expected Millennium Development Goals (MDGs, in reducing the MMR and IMR in the district Tuban, which will expire in 2015.

14 CFR 431.73 - Continuing accuracy of license application; application for modification of license.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Continuing accuracy of license application; application for modification of license. 431.73 Section 431.73 Aeronautics and Space COMMERCIAL SPACE... Conditions § 431.73 Continuing accuracy of license application; application for modification of license. (a...

NRC's license renewal regulations

International Nuclear Information System (INIS)

Akstulewicz, Francis

1991-01-01

In order to provide for the continuity of the current generation of nuclear power plant operating licenses and at the same time ensure the health and safety of the public, and the quality of the environment, the US Nuclear Regulatory Commission (NRC) established a goal of developing and issuing regulations and regulatory guidance for license renewal in the early 1990s. This paper will discuss some of those activities underway to achieve this goal. More specifically, this paper will discuss the Commission's regulatory philosophy for license renewal and the two major license renewal rule makings currently underway. The first is the development of a new Part 54 to address procedural and technical requirements for license renewal; the second is a revision to existing Part 51 to exclude environmental issues and impacts from consideration during the license renewal process. (author)

Licensed Healthcare Facilities

Data.gov (United States)

California Natural Resource Agency — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

2015 Business Licenses

Data.gov (United States)

City of Jackson, Mississippi — This data displays all business license information for the year of 2015. This information details license classifications and status. This information will updated...

Teenagers' licensing decisions and their views of licensing policies: a national survey.

Science.gov (United States)

Williams, Allan F

2011-08-01

One objective was to determine teenage licensing rates on a national basis, interest in early licensure, and reasons for delay. A second objective was to learn teenagers' opinions about licensing policies, important in states considering ways to upgrade their current licensing systems. One thousand three hundred eighty-three 15- to 18-year-olds completed an online survey in November 2010. They were drawn from a nationally representative panel of US households recruited using probability-based sampling. The panel included cell phone-only households, and Internet access was provided to those without it. Weighting procedures were applied so that the study population represented the national US population of 15- to 18-year-olds. Most teens said that they were interested in getting a license as soon as legally possible, but many had not started the process. At 16, teens were about equally divided among those who had not started, those in the learner stage, and those with a restricted or full license. At 18, 62 percent had full licenses; 22 percent had not started. For those old enough to start, lack of a car, costs, parent availability, ability to get around without a car, and being busy with other activities were leading reasons for delay. The majority of teens were not in favor of higher licensing ages. Forty-six percent thought the minimum learner age should be 16; 30 percent thought the full license age should be 18 or older. The majority approved of night (78%) and passenger (57%) restrictions, and 85 and 93 percent endorsed cell phone and texting bans, respectively. When these policies were packaged together in a single law that included an age 16 start, night, passenger, cell phone and texting bans, and a full license at age 18, 74 percent of teens were in favor. Teenagers are not as supportive of strong licensing policies as parents of teens, but there is evidence that they will support comprehensive policies likely to lead to further reductions in teen crash

Radiopharmaceutical licensing

International Nuclear Information System (INIS)

Mather, S.J.

1992-01-01

Recent health service legislation, and especially the loss of crown immunity has once again focussed attention on the arrangements for licensing of radiopharmaceuticals. The aim of the article is to describe in general terms the UK licensing system and in particular to provide guidance to those responsible for the supply of radiopharmaceuticals in hospitals. (author)

State Licenses & Permits

Data.gov (United States)

Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

Operator licensing examiner standards

International Nuclear Information System (INIS)

1983-10-01

The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

The SLOWPOKE licensing model

Energy Technology Data Exchange (ETDEWEB)

Snell, V. G.; Takats, F.; Szivos, K.

1989-08-15

The SLOWPOKE Energy System (SES-10) is a 10 MW heating reactor that has been developed in Canada. It will be capable of running without a licensed operator in continuous attendance, and will be sited in urban areas. It has forgiving safety characteristics, including transient time-scales of the order of hours. A process called `up-front` licensing has been evolved in Canada to identify, and resolve, regulatory concerns early in the process. Because of the potential market in Hungary for nuclear district heating, a licensing plan has been developed that incorporates Canadian licensing experience, identifies specific Hungarian requirements, and reduces the risk of licensing delays by seeking agreement of all parties at an early stage in the program.

License to build

International Nuclear Information System (INIS)

Huntelaar, Mark; Vos, Renate de; Roobol, Lars

2007-01-01

Full text: A new license under the nuclear power act is applied for at the Dutch Government for the building of a High Active Repackaging Unit (HAVA-VU in Dutch) at NRG in Petten, The Netherlands. This new building is necessary to comply with our nuclear license to dispose of high active nuclear waste at Petten to the intermediate storage facility (COVRA). In the first part of this paper attention is given to the formal procedure followed by the Government, what type of documents are to be submitted, what time frames are followed, how citizen participation is organized, and as final result a new license. In the second part more detailed information is given about the present license renewal needed for the High Active Repackaging Unit

Evaluation of Terminated Nuclear Material Licenses

International Nuclear Information System (INIS)

Spencer, K.M.; Zeighami, E.A.

1999-01-01

This report presents the results of a six-year project that reviewed material licenses that had been terminated during the period from inception of licensing until approximately late-1994. The material licenses covered in the review project were Part 30, byproduct material licenses; Part 40, source material licenses; and Part 70, special nuclear material licenses. This report describes the methodology developed for the project, summarizes the findings of the license file inventory process, and describes the findings of the reviews or evaluations of the license files. The evaluation identified nuclear material use sites that need review of the licensing material or more direct follow-up of some type. The review process also identified licenses authorized to possess sealed sources for which there was incomplete or missing documentation of the fate of the sources

Nuclear plant license renewal

International Nuclear Information System (INIS)

Gazda, P.A.; Bhatt, P.C.

1991-01-01

During the next 10 years, nuclear plant license renewal is expected to become a significant issue. Recent Electric Power Research Institute (EPRI) studies have shown license renewal to be technically and economically feasible. Filing an application for license renewal with the Nuclear Regulatory Commission (NRC) entails verifying that the systems, structures, and components essential for safety will continue to perform their safety functions throughout the license renewal period. This paper discusses the current proposed requirements for this verification and the current industry knowledge regarding age-related degradation of structures. Elements of a license renewal program incorporating NRC requirements and industry knowledge including a schedule are presented. Degradation mechanisms for structural components, their significance to nuclear plant structures, and industry-suggested age-related degradation management options are also reviewed

Challenges of SMR licensing practices

Energy Technology Data Exchange (ETDEWEB)

Soderholm, K., E-mail: kristiina.soderholm@fortum.com [Fortum Power, Espoo (Finland)

2012-12-15

This paper aims to increase the understanding of high level Nuclear Power Plant (NPP) licensing processes in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their different licensing processes and recent actions in new NPP construction. After discussing their similarities and differences, suitable features for Small Modular Reactor licensing can be emphasized and suggested. Some of the studied licensing processes have elements that are already quite well suited for application to SMRs, but all of these different national processes can benefit from studying and implementing lessons learned from SMR specific licensing needs. The main SMR features to take into account in licensing are standardization of the design, modularity, mass production and serial construction. Modularity can be divided into two different categories: the first category is simply a single unit facility constructed of independently engineered modules (e.g., construction process for Westinghouse AP-1000 NPP) and the second is a facility structure composed of many reactor modules where modules are manufactured in factories and installed into the facility as needed (e.g., NuScale Power SMR design). Short construction schedules will not be fully benefited from if the long licensing process prolongs the commissioning and approach to full-power operation. The focus area of this study is to better understand the possibility of SMR deployment in small nuclear countries, such as Finland, which currently has four operating NPPs. The licensing process needs to be simple and clear to make SMR deployment feasible from an economical point of view. This paper uses public information and interviews with experts to establish the overview of the different licensing processes and their main steps. A high-level comparison of the licensing steps has been carried out. Certain aspects of the aviation industry licensing process have also been studied and certain

31 CFR 596.306 - License.

Science.gov (United States)

2010-07-01

... ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.306 License. Except as otherwise specified, the term license means any license or...

Understanding Licensing Behavior

DEFF Research Database (Denmark)

Cabaleiro, Goretti; Moreira, Solon; Reichstein, Toke

The potential for rent dissipation has been argued to be the main cause of firms? licensing out behavior being stifled.However, this aspect has been scarcely studied empirically. We draw on rent dissipation arguments, and hypothesize that firms suffering from the not-invented-here (NIH) syndrome......, firms in competitive product markets, and firms that have incurred substantial sunk cost are associated with lower rates of technology out-licensing. We also posit that sunk costs negatively moderate the relationship between competition in the licensor?s product market, and licensing rate. We test our...

Nuclear power stations licensing

International Nuclear Information System (INIS)

Solito, J.

1978-04-01

The judicial aspects of nuclear stations licensing are presented. The licensing systems of the United States, Spain, France and Federal Republic of Germany are focused. The decree n 0 60.824 from July 7 sup(th), 1967 and the following legislation which define the systematic and area of competence in nuclear stations licensing are analysed [pt

Two-dimensional statistical linear discriminant analysis for real-time robust vehicle-type recognition

Science.gov (United States)

Zafar, I.; Edirisinghe, E. A.; Acar, S.; Bez, H. E.

2007-02-01

Automatic vehicle Make and Model Recognition (MMR) systems provide useful performance enhancements to vehicle recognitions systems that are solely based on Automatic License Plate Recognition (ALPR) systems. Several car MMR systems have been proposed in literature. However these approaches are based on feature detection algorithms that can perform sub-optimally under adverse lighting and/or occlusion conditions. In this paper we propose a real time, appearance based, car MMR approach using Two Dimensional Linear Discriminant Analysis that is capable of addressing this limitation. We provide experimental results to analyse the proposed algorithm's robustness under varying illumination and occlusions conditions. We have shown that the best performance with the proposed 2D-LDA based car MMR approach is obtained when the eigenvectors of lower significance are ignored. For the given database of 200 car images of 25 different make-model classifications, a best accuracy of 91% was obtained with the 2D-LDA approach. We use a direct Principle Component Analysis (PCA) based approach as a benchmark to compare and contrast the performance of the proposed 2D-LDA approach to car MMR. We conclude that in general the 2D-LDA based algorithm supersedes the performance of the PCA based approach.

It's About Me: Patients' Experiences of Patient Participation in the Web Behavior Change Program for Activity in Combination With Multimodal Pain Rehabilitation.

Science.gov (United States)

Nordin, Catharina; Michaelson, Peter; Eriksson, Margareta K; Gard, Gunvor

2017-01-18

Patients' participation in their health care is recognized as a key component in high-quality health care. Persons with persistent pain are recommended treatments with a cognitive approach from a biopsychosocial explanation of pain, in which a patient's active participation in their rehabilitation is in focus. Web-based interventions for pain management have the potential to increase patient participation by enabling persons to play a more active role in rehabilitation. However, little is known about patients' experiences of patient participation in Web-based interventions in clinical practice. The objective of our study was to explore patients' experiences of patient participation in a Web Behavior Change Program for Activity (Web-BCPA) in combination with multimodal rehabilitation (MMR) among patients with persistent pain in primary health care. Qualitative interviews were conducted with 15 women and 4 men, with a mean age of 45 years. Data were analyzed with qualitative content analysis. One theme, "It's about me," and 4 categories, "Take part in a flexible framework of own priority," "Acquire knowledge and insights," "Ways toward change," and "Personal and environmental conditions influencing participation," were developed. Patient participation was depicted as being confirmed in an individualized and structured rehabilitation framework of one's own choice. Being confirmed was fundamental to patient participation in the interaction with the Web-BCPA and with the health care professionals in MMR. To acquire knowledge and insights about pain and their life situation, through self-reflection in the solitary work in the Web-BCPA and through feedback from the health care professionals in MMR, was experienced as patient participation by the participants. Patient participation was described as structured ways to reach their goals of behavior change, which included analyzing resources and restrictions, problem solving, and evaluation. The individual's emotional and

FOSS License Selection and Code Management

OpenAIRE

Vescuso, Peter

2011-01-01

With nearly 2,000 free and open source software (FLOSS) licenses, software license proliferation¿ can be a major headache for software development organizations trying to speed development through software component reuse, as well as companies redistributing software packages as components of their products. Scope is one problem: from the Free Beer license to the GPL family of licenses to platform-specific licenses such as Apache and Eclipse, the number and variety of licenses make it difficu...

Learning-by-Licensing: How Chinese Firms Benefit From Licensing-In Technologies

DEFF Research Database (Denmark)

Wang, Yuandi; Roijakkers, N.; Vanhaverbeke, W.

2012-01-01

This paper explores how interfirm variations in their in-licensed technology portfolios influence subsequent innovation performance. Existing studies mainly assume licensed technologies are homogeneously accessible to firms, and a prevailing explanation as to why firms vary in their innovation pe...

Decommissioning and decontamination of licensed reactor facilities and demonstration nuclear power plants

International Nuclear Information System (INIS)

Lear, G.; Erickson, P.B.

1975-01-01

Decommissioning of licensed reactors and demonstration nuclear power plants has been accomplished by mothballing (protective storage), entombment, and dismantling or a combination of these three. The alternative selected by a licensee seems to be primarily based on cost. A licensee must, however, show that the decommissioning process provides adequate protection of the health and safety of the public and no adverse impact on the environment. To date the NRC has approved each of the alternatives in the decommissioning of different facilities. The decommissioning of small research reactors has been accomplished primarily by dismantling. Licensed nuclear power plants, however, have been decommissioned primarily by being placed in a mothballed state in which they continue to retain a reactor license and the associated licensee responsibilities

Operator licensing examiner standards

International Nuclear Information System (INIS)

1993-01-01

The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

Flexible licensing

Directory of Open Access Journals (Sweden)

Martyn Jansen

2012-07-01

Full Text Available The case is presented for a more flexible approach to licensing online library resources. Today's distributed education environment creates pressure for UK higher and further education institutions (HEI/FEIs to form partnerships and to develop educational products and roll them out across the globe. Online library resources are a key component of distributed education and yet existing licensing agreements struggle to keep pace with the increasing range of users and purposes for which they are required. This article describes the process of developing a flexible approach to licensing and proposes a new model licence for online library resources which has the adaptability needed in this new global educational landscape. These ideas have been presented and discussed at various workshops across Eduserv's and JISC Collections' higher education and publisher communities, and further consultation is ongoing.

Licensing process characteristics of Small Modular Reactors and spent nuclear fuel repository

Energy Technology Data Exchange (ETDEWEB)

Söderholm, Kristiina, E-mail: kristiina.soderholm@fortum.com [Fortum Power (Finland); Tuunanen, Jari, E-mail: jari.tuunanen@fortum.com [Fortum Power (Finland); Amaba, Ben, E-mail: baamaba@us.ibm.com [IBM Complex Systems (United States); Bergqvist, Sofia, E-mail: sofia.bergqvist@se.ibm.com [IBM Rational Software (Sweden); Lusardi, Paul, E-mail: plusardi@nuscalepower.com [NuScale Power (United States)

2014-09-15

for spent nuclear fuel, such as the one planned to be built to Olkiluoto, Finland, is based on modular design and phased construction. In this case the disposal tunnels, bentonite buffer and backfill and the disposal canisters can be considered as modules. Due to its phased construction the facility has similar licensing characteristics of SMRs. A common licensing process needs to be simple and clear to ensure the feasibility of construction and deployment of SMR's as well as the deep geological repositories. One of the important aspects of nuclear licensing is the compliance to licensing requirements. In a discrete and transparent matter, systems engineering (SE) and requirements engineering (RE) are discussed with the licensing development. The sheer number of licensing requirements is daunting, interconnected in a complex fashion and long-lasting. The process and tools play a critical role in the success of the licensing effort. A few proposed examples of combined SMR and deep repository licensing applications are discussed using SE and RE principles. A synergistic discussion on licensing models, nuclear licensing simplification, as well as international approach in licensing, will be needed in the future. This would be a natural continuation to the collaborative efforts in Europe underway for existing and new large reactors.

Trends in nuclear licensing

Energy Technology Data Exchange (ETDEWEB)

Dalton, N W [Council for Nuclear Safety, Hennopsmeer, Pretoria (South Africa)

1990-06-01

The development of nuclear safety and licensing is briefly reviewed in four stages namely: The Formative Period (1946-1959), The Expansive Period (1960-1969), The Mature Period (1970-1979) and the Apprehensive Period (1980-1989). Particular safety issues in the respective periods are highlighted to indicate the changing emphasis of nuclear licensing over the past thirty years or so. Against this background, nuclear licensing. (author)

Trends in nuclear licensing

International Nuclear Information System (INIS)

Dalton, N.W.

1990-01-01

The development of nuclear safety and licensing is briefly reviewed in four stages namely: The Formative Period (1946-1959), The Expansive Period (1960-1969), The Mature Period (1970-1979) and the Apprehensive Period (1980-1989). Particular safety issues in the respective periods are highlighted to indicate the changing emphasis of nuclear licensing over the past thirty years or so. Against this background, nuclear licensing. (author)

Licensing process for safety-critical software-based systems

Energy Technology Data Exchange (ETDEWEB)

Haapanen, P. [VTT Automation, Espoo (Finland); Korhonen, J. [VTT Electronics, Espoo (Finland); Pulkkinen, U. [VTT Automation, Espoo (Finland)

2000-12-01

System vendors nowadays propose software-based technology even for the most critical safety functions in nuclear power plants. Due to the nature of software faults and the way they cause system failures new methods are needed for the safety and reliability evaluation of these systems. In the research project 'Programmable automation systems in nuclear power plants (OHA)', financed together by the Radiation and Nuclear Safety Authority (STUK), the Ministry of Trade and Industry (KTM) and the Technical Research Centre of Finland (VTT), various safety assessment methods and tools for software based systems are developed and evaluated. As a part of the OHA-work a reference model for the licensing process for software-based safety automation systems is defined. The licensing process is defined as the set of interrelated activities whose purpose is to produce and assess evidence concerning the safety and reliability of the system/application to be licensed and to make the decision about the granting the construction and operation permissions based on this evidence. The parties of the licensing process are the authority, the licensee (the utility company), system vendors and their subcontractors and possible external independent assessors. The responsibility about the production of the evidence in first place lies at the licensee who in most cases rests heavily on the vendor expertise. The evaluation and gauging of the evidence is carried out by the authority (possibly using external experts), who also can acquire additional evidence by using their own (independent) methods and tools. Central issue in the licensing process is to combine the quality evidence about the system development process with the information acquired through tests, analyses and operational experience. The purpose of the licensing process described in this report is to act as a reference model both for the authority and the licensee when planning the licensing of individual applications

Licensing process for safety-critical software-based systems

International Nuclear Information System (INIS)

Haapanen, P.; Korhonen, J.; Pulkkinen, U.

2000-12-01

System vendors nowadays propose software-based technology even for the most critical safety functions in nuclear power plants. Due to the nature of software faults and the way they cause system failures new methods are needed for the safety and reliability evaluation of these systems. In the research project 'Programmable automation systems in nuclear power plants (OHA)', financed together by the Radiation and Nuclear Safety Authority (STUK), the Ministry of Trade and Industry (KTM) and the Technical Research Centre of Finland (VTT), various safety assessment methods and tools for software based systems are developed and evaluated. As a part of the OHA-work a reference model for the licensing process for software-based safety automation systems is defined. The licensing process is defined as the set of interrelated activities whose purpose is to produce and assess evidence concerning the safety and reliability of the system/application to be licensed and to make the decision about the granting the construction and operation permissions based on this evidence. The parties of the licensing process are the authority, the licensee (the utility company), system vendors and their subcontractors and possible external independent assessors. The responsibility about the production of the evidence in first place lies at the licensee who in most cases rests heavily on the vendor expertise. The evaluation and gauging of the evidence is carried out by the authority (possibly using external experts), who also can acquire additional evidence by using their own (independent) methods and tools. Central issue in the licensing process is to combine the quality evidence about the system development process with the information acquired through tests, analyses and operational experience. The purpose of the licensing process described in this report is to act as a reference model both for the authority and the licensee when planning the licensing of individual applications. Many of the

Streamlining the license renewal review process

International Nuclear Information System (INIS)

Dozier, J.; Lee, S.; Kuo, P.T.

2001-01-01

The staff of the NRC has been developing three regulatory guidance documents for license renewal: the Generic Aging Lessons Learned (GALL) report, Standard Review Plan for License Renewal (SRP-LR), and Regulatory Guide (RG) for Standard Format and Content for Applications to Renew Nuclear Power Plant Operating Licenses. These documents are designed to streamline the license renewal review process by providing clear guidance for license renewal applicants and the NRC staff in preparing and reviewing license renewal applications. The GALL report systematically catalogs aging effects on structures and components; identifies the relevant existing plant programs; and evaluates the existing programs against the attributes considered necessary for an aging management program to be acceptable for license renewal. The GALL report also provides guidance for the augmentation of existing plant programs for license renewal. The revised SRP-LR allows an applicant to reference the GALL report to preclude further NRC staff evaluation if the plant's existing programs meet the criteria described in the GALL report. During the review process, the NRC staff will focus primarily on existing programs that should be augmented or new programs developed specifically for license renewal. The Regulatory Guide is expected to endorse the Nuclear Energy Institute (NEI) guideline, NEI 95-10, Revision 2, entitled 'Industry Guideline for Implementing the Requirements of 10 CFR Part 54 - The License Renewal Rule', which provides guidance for preparing a license renewal application. This paper will provide an introduction to the GALL report, SRP-LR, Regulatory Guide, and NEI 95-10 to show how these documents are interrelated and how they will be used to streamline the license renewal review process. This topic will be of interest to domestic power utilities considering license renewal and international ICONE participants seeking state-of-the-art information about license renewal in the United States

Economics of license renewal in the U.S. - entergy's perspective

International Nuclear Information System (INIS)

Young, Garry G.

2003-01-01

License renewal of operating nuclear plants in the United States has become one of the most successful U.S. nuclear regulatory activities in the past few years. In 1995, the U.S. Nuclear Regulatory Commission (NRC) published a revised rule in 10 CFR Part 54 that provided the requirements for an operating nuclear plant to seek license renewal. At that time, many people believed that only a select few operating nuclear plants would pursue license renewal and that most plants would operate for no more than 40 years. By mid-2003, the owners of approximately 52% of the U.S. nuclear fleet of 103 operating nuclear plants have decided to pursue license renewal and more are expected to follow. This change in direction since 1995 can be attributed to the improving economics of U.S. nuclear power plant operation and to the improved regulatory process resulting from the 1995 revision to 10 CFR Part 54. In 2000, Entergy submitted a license renewal application for Arkansas Nuclear One, Unit 1 (ANO-1). This application was the third to be submitted to the NRC at a time when it was still unclear how successful the regulatory process might be. However, less than 17 months later, in June 2001, the NRC granted a renewed operating license for ANO-1 at a total cost of approximately $11 million. Due in part to the ANO-1 license renewal success, Entergy now has tentative plans to pursue license renewal for the entire fleet of operating nuclear power plants. Without license renewal, Entergy's current nuclear fleet capacity of approximately 9,000 MW(e) would begin to decline in 2012. With license renewal, Entergy's nuclear fleet capacity can remain in place until 2032. This projection does not include the expected improvements in capacity due to power uprate that is currently planned. The combination of power uprate and license renewal will add significant economic value to Entergy's nuclear fleet. One of the major factors in strong performance is capacity factor. In 1990, the average

The Monticello license renewal project

International Nuclear Information System (INIS)

Clauss, J.M.; Harrison, D.L.; Pickens, T.A.

1993-01-01

Today, 111 nuclear power plants provide over 20 percent of the electrical energy generated in the United States. The operating license of the oldest operating plant will expire in 2003, one-third of the existing operating licenses will expire by 2010 and the newest plant's operating license will expire in 2033. The National Energy Strategy (NES) prepared by the Department of Energy (DOE) assumes that 70 percent of the current operating plants will continue to operate beyond their current license expiration. Power from current operating plants can assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth and improved U.S. competitiveness. In order to preserve this energy resource, three major tasks must be successfully completed: (1) establishment of regulations, technical standards, and procedures for the preparation and review of License Renewal Applications (LRAs); (2) development of technical criteria and bases for monitoring, refurbishing or replacing plant equipment; and (3) demonstration of the regulatory process by a plant obtaining a renewed license. Since 1986, the DOE has been working with the nuclear industry and the Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of a nuclear power plant by renewing the operating license. The Monticello Lead Plant demonstration project was initiated in September 1988, following the Pilot Plant studies. This paper is primarily focused on the status and insights gained from the Northern States Power Company (NSP) Monticello Lead Plant demonstration project. The following information is included: (1) Current Status - Monticello License Renewal Application; (2) Economic Analysis; (3) License Renewal Regulatory Uncertainty Issues; (4) Key Decisions; (5) Management Structure; (6) Technical and Licensing Perspective; (7) NRC Interactions; (8) Summary

The comparison of license management procedure for nuclear power plant in China and United States

International Nuclear Information System (INIS)

Yu Zusheng

2006-01-01

'Tow steps' license management procedure for nuclear power plant has been performed bas- ted on the requirement of 10CFR Part50-DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES in United States since last century fifties. In order to ulterior reduce the risk of investment and technical for new construction nuclear power plants, new regulations 'One step' license management procedure-10CFR Part52-EARLY SITE PERMITS; STANDARD DESIGN CERTIFICATIONS; AND COMBINED LICENSES FOR NUCLEAR POWER PLANTS issued in 1989. The new regulations has been adopted by new design of nuclear power plant, for example AP1000. ‘The similar tow steps’ license management procedure for nuclear power plant has been performed basted on the requirement of HAFO01/01 Rules for the Implementation of Regulations on the Safety Regulation for Civilian Nuclear Installations of the People's Re- public of China Part One: Application and Issuance of Safety License for Nuclear Power Plant (December 1993) in China since last century nineties. This article introduces and compares the requirements and characteristics of above license management procedure for nuclear power plant in China and United States. (author)

NUMARC view of license renewal criteria

International Nuclear Information System (INIS)

Edwards, D.W.

1989-01-01

The Atomic Energy Act and the implementing regulations of the US Nuclear Regulatory Commission (NRC) permit the renewal of nuclear plant operating licenses upon expiration of their 40-year license term. However, the regulatory process by which license renewal may be accomplished and the requirements for the scope and content of renewal applications are yet to be established. On August 29, 1988, the NRC published an Advanced Notice of Proposed Rulemaking regarding the subject of license renewal. This Advanced Notice and the NUREG which it references, NUREG-1317, Regulatory Options for Nuclear Plant License Renewal, provide the most recent regulatory thought on this issue. The basic issue addressed by NUREG-1317 is the definition of an adequate licensing basis for the renewal of a plant license. The report contemplates three alternatives in this regard. This paper discusses each of these three proposals. The NUMARC NUPLEX Working Group endorses a license renewal process based on a plant's current licensing basis along with an evaluation of the pertinent components, systems, and structures affected by age-related degradation. The NUMARC NUPLEX Working group believes that an appropriate scope for NRC review of the license renewal application should focus on those safety-significant structures systems, and components subject to significant age-related degradation that are not subject to existing recognized effective replacement, refurbishment, or inspection programs. The paper also briefly discusses NUMARC's view of the role of the Backfit Rule in the license renewal process

Graduated driver licensing and differential deterrence: The effect of license type on intentions to violate road rules.

Science.gov (United States)

Poirier, Brigitte; Blais, Etienne; Faubert, Camille

2018-01-01

In keeping with the differential deterrence theory, this article assesses the moderating effect of license type on the relationship between social control and intention to violate road rules. More precisely, the article has two objectives: (1) to assess the effect of license type on intentions to infringe road rules; and (2) to pinpoint mechanisms of social control affecting intentions to violate road rules based on one's type of driver license (a restricted license or a full license). This effect is examined among a sample of 392 young drivers in the province of Quebec, Canada. Drivers taking part in the Graduated Driver Licensing (GDL) program have limited demerit points and there is zero tolerance for drinking-and-driving. Propensity score matching techniques were used to assess the effect of the license type on intentions to violate road rules and on various mechanisms of social control. Regression analyses were then conducted to estimate the moderating effect of license type. Average treatment effects from propensity score matching analyses indicate that respondents with a restricted license have lower levels of intention to infringe road rules. While moral commitment and, to a lesser extent, the perceived risk of arrest are both negatively associated with intentions to violate road rules, the license type moderates the relationship between delinquent peers and intentions to violate road rules. The effect of delinquent peers is reduced among respondents with a restricted driver license. Finally, a diminished capability to resist peer pressure could explain the increased crash risk in months following full licensing. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Usefulness of Patent Stage and Sectoral Pattern in Open Innovation Licensing

Directory of Open Access Journals (Sweden)

Jun Young Kim

2008-12-01

Full Text Available The relative importance to the particular industry of licensing has not been done enough empirically to pursue the route of the open innovation. That is why the industrial level research on open innovation is more complicated than that of company level. This paper tries to survey industrial level licensing by combining the technology regime theory with NTB(National Technology Bank score model of KTTC(Korea Technology Transfer Center and tries to transform Likert score into general value proxy by using information of valuator’s organizations. This paper also introduces two new factors named as ‘patent authorization stage’ for classifying patent status and ‘technology regime based industrial innovation pattern’ for adopting sectoral level research in order to overcome drawbacks of score model in case of application to open innovation licensing.

Establishing a safety and licensing basis for generation IV advanced reactors. License by test

International Nuclear Information System (INIS)

Kadak, Andrew C.

2001-01-01

The license by test approach to licensing is a novel method of licensing reactors. It provides an opportunity to deal with innovative non-water reactors in a direct way on a time scale that could permit early certification based on tests of a demonstration reactor. The uncertainties in the design and significant contributors to risk would be identified in the PRA during the design. Deterministic analysis computer codes could be tested on a real reactor. Scaling effects and associated uncertainties would be minimized. License by test is an approach that has sufficient merit to be developed and tested

22 CFR 96.30 - State licensing.

Science.gov (United States)

2010-04-01

... Licensing and Corporate Governance § 96.30 State licensing. (a) The agency or person is properly licensed or... person follows applicable State licensing and regulatory requirements in all jurisdictions in which it provides adoption services. (c) If it provides adoption services in a State in which it is not itself...

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-07-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-05-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1983-01-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1983-03-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-11-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-10-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-08-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-09-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operator licensing examiner standards

International Nuclear Information System (INIS)

1994-06-01

The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

Licensing in an International Market

Science.gov (United States)

Ferreira, Fernanda A.

2008-09-01

We study the effects of entry of a foreign firm on domestic welfare in the presence of licensing, when the entrant is technologically superior to the incumbent. We show that foreign entry increases domestic welfare for sufficiently large technological differences between the firms under both fixed-fee licensing and royalty licensing.

22 CFR 120.20 - License.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false License. 120.20 Section 120.20 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.20 License. License means a document bearing the word “license” issued by the Directorate of Defense Trade...

48 CFR 227.7203-4 - License rights.

Science.gov (United States)

2010-10-01

... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The... license, under an irrevocable license granted or obtained by the contractor which developed the software... granted to the Government. The scope of a computer software license is generally determined by the source...

Current status of construction license of PEFP

International Nuclear Information System (INIS)

Kim, J. Y.; Cho, J. S.; Min, Y. S.; Nam, J. M.; Jeon, G. P.; Park, S. S.; Jo, J. H.; Song, I. T.

2012-01-01

Since 2010 August, PEFP(Proton Engineering Frontier Project)'s Proton Accelerator Research Center has been under construction so far. Generally, in advance of construction startup, many kinds of licenses should be acquired along with the types of construction works. To acquire a license in time, each item should meet the standard by the related regulation, including not only procedural but also content aspect. In the advent of internet era, electronic government system has been adopted in many governmental functions: So is the national construction license acquisition system. Owing to the system, both approval and documentation functions in licensing are integrated in online computer network which provide us simplification in process and easy accessibility to license data. However, aside from these construction licenses, other types of licenses still remain separately managed: Machinery, electric facilities, and so on. Moreover, all the licenses have the priority order and take legal term in processing. So, to avoid any time delay in license acquisition, we organized license hierarchy and found out the priority among them. Thereafter, according to their legal term in approval and acquisition, whole license acquisition schedule was arranged and we completed all the necessary licenses acquisition in time In this study, we summarize the current status of license acquisition on Proton Accelerator Research Center Construction, and manifest how they have been and will be managed systematically

Current status of construction license of PEFP

Energy Technology Data Exchange (ETDEWEB)

Kim, J. Y.; Cho, J. S.; Min, Y. S.; Nam, J. M.; Jeon, G. P.; Park, S. S.; Jo, J. H.; Song, I. T. [KAERI, Daejeon (Korea, Republic of)

2012-10-15

Since 2010 August, PEFP(Proton Engineering Frontier Project)'s Proton Accelerator Research Center has been under construction so far. Generally, in advance of construction startup, many kinds of licenses should be acquired along with the types of construction works. To acquire a license in time, each item should meet the standard by the related regulation, including not only procedural but also content aspect. In the advent of internet era, electronic government system has been adopted in many governmental functions: So is the national construction license acquisition system. Owing to the system, both approval and documentation functions in licensing are integrated in online computer network which provide us simplification in process and easy accessibility to license data. However, aside from these construction licenses, other types of licenses still remain separately managed: Machinery, electric facilities, and so on. Moreover, all the licenses have the priority order and take legal term in processing. So, to avoid any time delay in license acquisition, we organized license hierarchy and found out the priority among them. Thereafter, according to their legal term in approval and acquisition, whole license acquisition schedule was arranged and we completed all the necessary licenses acquisition in time In this study, we summarize the current status of license acquisition on Proton Accelerator Research Center Construction, and manifest how they have been and will be managed systematically.

Technology Licensing and Firm Innovation

DEFF Research Database (Denmark)

Moreira, Solon

acquisition. The findings indicate that technology licensing is positively related to the number of inventions produced by the licensee in the years subsequent to the licensing deal. Subsequently, I investigate the moderating effect that organizational slack and myopia have on this main relationship....... The findings also suggest that high levels of Organizational Slack (available financial resources) strengthen the positive effect of licensing on innovation. However, higher levels of Organizational Myopia (the extent to which a firm draws on its own knowledge) can decrease the main effect of licensing....

31 CFR 596.309 - Specific license.

Science.gov (United States)

2010-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.309 Specific license. The term specific license means any license or...

Online driver's license renewal.

Science.gov (United States)

2015-09-01

The Kentucky Department of Vehicle Regulation is exploring the possibility of developing and implementing online : drivers license renewal. The objective of this project was to: 1) evaluate online drivers license and REAL ID renewal : programs ...

The need for legislative framework (licensing)

International Nuclear Information System (INIS)

Krech, H.

1977-01-01

For reasons of public acceptance the basis of a licensing system should be laid down in a law, details can be fixed in regulations below the law-level. The competence for licensing nuclear installations should be attributed to one body, which is not a the same time charged with the promotion of nuclear energy. The licensing authority has to be provided with sufficient technical advice, given by experts organized in advisory bodies. Normally a licensing procedure is split into several steps (site approval, construction permit, operation licence), each step can be subdivided. Some general aspects of licensing conditions (personal, technical and financial) as well as of the licensing procedure are outlined. The participation of the public is of particular importance but also involves most intricate problems. The paper concludes with some critical remarks on the role of administrative courts with respect to the licensing of nuclear power plants. (orig.) [de

31 CFR 596.305 - General license.

Science.gov (United States)

2010-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.305 General license. The term general license means any license or authorization...

77 FR 1748 - Atomic Safety and Licensing Board; Calvert Cliffs 3 Nuclear Project, LLC, and UniStar Nuclear...

Science.gov (United States)

2012-01-11

... under represents potential contributions of wind and solar power, the combination alternative depends... Judge Ronald M. Spritzer, Atomic Safety and Licensing Board Panel, Mail Stop T-3F23, U.S. Nuclear..., Atomic Safety and Licensing Board Panel, Mail Stop T-3F23, U.S. Nuclear Regulatory Commission. Fax: (301...

Licensing an assured isolation facility for low-level radioactive waste. Volume 1: Licensing strategy and issues

International Nuclear Information System (INIS)

Silverman, D.J.; Bauser, M.A.; Baird, R.D.

1998-07-01

This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

EMPIRICAL STUDY OF CAR LICENSE PLATES RECOGNITION

Directory of Open Access Journals (Sweden)

Nasa Zata Dina

2015-01-01

Full Text Available The number of vehicles on the road has increased drastically in recent years. The license plate is an identity card for a vehicle. It can map to the owner and further information about vehicle. License plate information is useful to help traffic management systems. For example, traffic management systems can check for vehicles moving at speeds not permitted by law and can also be installed in parking areas to se-cure the entrance or exit way for vehicles. License plate recognition algorithms have been proposed by many researchers. License plate recognition requires license plate detection, segmentation, and charac-ters recognition. The algorithm detects the position of a license plate and extracts the characters. Various license plate recognition algorithms have been implemented, and each algorithm has its strengths and weaknesses. In this research, I implement three algorithms for detecting license plates, three algorithms for segmenting license plates, and two algorithms for recognizing license plate characters. I evaluate each of these algorithms on the same two datasets, one from Greece and one from Thailand. For detecting li-cense plates, the best result is obtained by a Haar cascade algorithm. After the best result of license plate detection is obtained, for the segmentation part a Laplacian based method has the highest accuracy. Last, the license plate recognition experiment shows that a neural network has better accuracy than other algo-rithm. I summarize and analyze the overall performance of each method for comparison.

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1982-04-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis

MMR Vaccine (Measles, Mumps, and Rubella)

Science.gov (United States)

Mumpsvax® Mumps Vaccine ... Biavax® II (as a combination product containing Mumps Vaccine, Rubella Vaccine) ... II (as a combination product containing Measles Vaccine, Mumps Vaccine, Rubella Vaccine)

Licensing aspects regarding the RBMN project

International Nuclear Information System (INIS)

Cuccia, Valeria; Sacramento, Arivaldo M.; Aleixo, Bruna L.; Ferreira, Vinicius V.M.

2013-01-01

The licensing process of a waste disposal facility is a complex and demanding undertaking. It proceeds in phases, starting with the site selection and ending many decades later, when the radionuclides decayed and no longer offer possible hazard. That is one of the reasons why the licensing process for the Brazilian repository for low and intermediate level radioactive waste (RBMN Project) is a challenge for all the technicians involved. Besides that, the only national experience associated to this subject arose after a radiological accident in the State of Goias, in 1987. Two different institutions are involved in this licensing process: IBAMA, for environmental licensing, and CNEN, for nuclear licensing. Both of them will evaluate the possible impacts caused by the waste disposal, so it is essential to avoid conflicts and duplications of activities. The RBMN project has different teams for each main activity, and one of them is the Licensing group. This team has been planning the licensing activities for the repository, studying the legal framework and estimating costs and execution time for each step. This paper presents the status of the licensing activities regarding to the RBMN project done by the CNEN staff. (author)

Managing Licensing in a Market for Technology

DEFF Research Database (Denmark)

Arora, Ashish; Rønde, Thomas; Fosfuri, Andrea

the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend upon product market performance. If licensing is decentralized, the business unit forgoes valuable...... licensing opportunities since the rewards for licensing are (optimally) weaker than those for product market profits. This distortion is stronger when production-based incentives are more powerful, making centralization more attractive. Growth of technology markets favors centralization and drives higher...

Department of Energy licensing strategy

International Nuclear Information System (INIS)

Frei, M.W.

1984-01-01

The Department of Energy (DOE) is authorized by the Nuclear Waste Policy Act of 1982 (Act) to site, design, construct, and operate mined geologic repositories for high-level radioactive wastes and is required to obtain licenses from the Nuclear Regulatory Commission (NRC) to achieve that mandate. To this end the DOE has developed a licensing approach which defines program strategies and which will facilitate and ease the licensing process. This paper will discuss the regulatory framework within which the repository program is conducted, the DOE licensing strategy, and the interactions between DOE and NRC in implementing the strategy. A licensing strategy is made necessary by the unique technical nature of the repository. Such a facility has never before been licensed; furthermore, the duration of isolation of waste demanded by the proposed EPA standard will require a degree of reliance on probabilistic performance assessment as proof of compliance that is a first of a kind for any industry. The licensing strategy is also made necessary by the complex interrelationships among the many involved governmental agencies and even within DOE itself, and because these relationships will change with time. Program activities which recognize these relationships are essential for implementing the Act. The guiding principle in this strategy is an overriding commitment to safeguarding public health and safety and to protecting the environment

Application of up-front licensing

Energy Technology Data Exchange (ETDEWEB)

Grant, S D [Atomic Energy of Canada Ltd., Saskatoon, SK (Canada); Snell, V G [Atomic Energy of Canada Ltd., Mississauga, ON (Canada)

1996-12-31

AECL has been pioneering `up-front` licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs.

Application of up-front licensing

International Nuclear Information System (INIS)

Grant, S.D.; Snell, V.G.

1995-01-01

AECL has been pioneering 'up-front' licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs

Regulatory systems-based licensing guidance documentation

International Nuclear Information System (INIS)

Delligatti, M.S.

1991-01-01

The US Nuclear Regulatory Commission (NRC) has developed a series of licensing guidance documents based on the regulatory requirements in Part 60 of Title 10 of the Code of Federal Regulations (10 CFR Part 60). This regulatory systems-based approach to licensing guidance documentation relies on the definition of the high-level waste repository in 10 CFR Part 60. A document which is important for the frame-work it gives to other programmatic licensing guidance is the Draft Regulatory Guide open-quotes Format and Content for the License Application for the High-Level Waste Repositoryclose quotes (FCRG). The FCRG describes a format and content acceptable to NRC for a high-level waste repository license application pursuant to the requirements of 10 CFR Part 60. Other licensing guidance documents will be compatible with the FCRG

License renewal in the United States

International Nuclear Information System (INIS)

Brons, Jack

2002-01-01

Full text: Nuclear plants in the United States are licensed for 40 years, a length specified in the Atomic Energy Act of 1954, which laid out much of the regulatory basis for the commercial nuclear industry. The Act, however, made provision for license renewal. The original 40-year license period was chosen arbitrarily by the U.S. Congress because it was the typical period over which utilities recovered their investment in electricity generating plants. Nuclear plants, however, are subject to a rigorous program of Nuclear Regulatory Commission oversight, maintenance and equipment replacement. In effect, they must be in the same operating condition on the last day of their licenses as they were on the first. As the industry matured, it became apparent that there was no physical limitation on the continued operation of nuclear plants past 40 years. The industry turned its attention toward license renewal. When the issue was first raised, the NRC considered stringent process equivalent to seeking a new operating license for each plant. The complexity, length and cost of the process made it unlikely that many nuclear plants would seek license renewal. The nuclear industry worked successfully with NRC on the application of generic principles to license renewal, however, and in 1995, the NRC issued an efficient, tightly-focused rule that made license renewal a safe, viable option. To extend the operating license for a reactor, a company must demonstrate to the NRC that aging effects will be adequately managed during the renewal terms, thus ensuring equipment functionality. The rule allows licensees to apply for extensions of up to 20 years. The first license renewal application was filed in 1998 by the owner of the two-unit Calvert Cliffs plant. Shortly thereafter, an application was filed for the three-unit Oconee Nuclear Station. The NRC renewed the licenses for all five units in 2000, and since then, five more licenses have been renewed. The NRC has received 37

'Just that little bit of doubt': Scottish parents', teenage girls' and health professionals' views of the MMR, H1N1 and HPV vaccines.

Science.gov (United States)

Kennedy, Catriona; Gray Brunton, Carol; Hogg, Rhona

2014-02-01

Parental decision making about childhood vaccinations is complex and the vaccination schedule ever-changing. Vaccination may be controversial even in countries with historically high vaccination rates such as Scotland. Health behaviour models have aided understanding of individual vaccine intentions for specific vaccines. These are limited in explaining actual behaviours and are divorced from the impact of socio-cultural contexts on vaccination decision making. To explore vaccination views in Scotland amongst parents, teenage girls and health professionals across three controversial vaccines: the Measles, Mumps, Rubella (MMR), the Human Papilloma virus (HPV) and the Influenza A (H1N1) vaccine. We used qualitative interviews and focus group discussions in a purposive sample of health professionals (n = 51), parents (n = 15) and teenage girls aged 12-15 years (n = 8) about their views of these vaccines. Discussions were analysed using thematic analysis. Two main themes are highlighted: 'vaccine risks revisited' in which we explored how the MMR legacy resurfaced and how worries about vaccine safety permeated the data. 'Vaccine responsibilities' indicated tensions regarding roles and responsibilities for vaccines. An overarching notion of 'just that little bit of doubt' referred to lingering doubts and uncertainties interwoven across the vaccines. Public health authorities should remain alert towards pervasive vaccine concerns. It is important for authorities to clarify vaccine roles and responsibilities in the face of new and existing vaccines and to acknowledge public concerns regarding vaccine safety.

Licensing of away-from-reactor (AFR) installations

International Nuclear Information System (INIS)

Gray, P.L.

1980-01-01

Storage of spent fuel at Away-From-Reactor (AFR) installations will allow reactors to continue to operate until reprocessing or other fuel disposal means are available. AFR installations must be licensed by the Nuclear Regulatory Commission (NRC). Although wide experience in licensing reactors exists, the licensing of an AFR installation is a relatively new activity. Only one has been licensed to date. This paper delineates the requirements for licensing an AFR installation and projects a licensing schedule. Because the NRC is developing specific AFR requirements, this schedule is based primarily on draft NRC documents. The major documents needed for an AFR license application are similar to those for a reactor. They include: a Safety Analysis Report (SAR), and Environmental Report (ER), safeguards and security plans, decommissioning plans, proposed technical specifications, and others. However, the licensing effort has one major difference in that for AFR installations it will be a one-step effort, with follow-up, rather than the two-step process used for reactors. The projected licensing schedule shows that the elapsed time between filing an application and issuance of a license will be about 32 months, assuming intervention. The legal procedural steps will determine the time schedule and will override considerations of technical complexity. A license could be issued in about 14 months in the absence of intervention

CFD study of dominant effect in combined DTHT by using hypothetical boundary conditions

Energy Technology Data Exchange (ETDEWEB)

Nietiadi, Yohanes Setiawan; Lee, Jeong Ik [KAIST, Daejeon (Korea, Republic of); Addad, Yacine [KUSTAR, Abu Dhabi (United Arab Emirates)

2015-05-15

KAIST MMR is a gas cooled fast reactor (GFR) using supercritical CO{sub 2} as a working fluid of reactor core and power cycle without intermediate heat exchanger which operates in higher pressure and higher temperature conditions compared to PWR. During a Loss of Coolant Accident (LOCA), MMR needs to relay on passive Decay Heat Removal (DHR) system by using natural circulation of gas since passive decay heat removal using conduction and radiation is not providing sufficient decay heat removal. Very limited researches were conducted in the regime where both occur at the same time and in the same order of magnitude. Numerical analysis is done with v''2-f turbulence model to predict the physical phenomena for the future experimental work. The effects of buoyancy and acceleration were studied with CFD for designed cases to distinguish the dominant effect in the combined DTHT regime. Numerical results of the v''2-f turbulence model show that the model can predict the buoyancy induced DTHT phenomenon even when the acceleration parameter is greater than buoyancy parameter but there is no data that shows that acceleration induced DTHT dominates the DTHT phenomena at this moment. More numerical results in the combined DTHT regime will be obtained and studied to provide clearer view on strongly heated turbulent flow and its heat transfer deteriorating mechanism. Adjustment for v''2-f turbulence model to correct the prediction of buoyancy effect will be studied in the near future.

Free Software Licenses and Other Free Licenses: Genetic Code of Digital Common Goods

OpenAIRE

Marco Ciurcina

2017-01-01

This article explores the history and describes the main features of free software licenses and other free licenses in an attempt to shed light on the reasons for their success in promoting individual behaviors converging towards the collective construction of digital commons.

Managing Licensing in a Market for Technology

DEFF Research Database (Denmark)

Arora, Ashish; Fosfuri, Andrea; Rønde, Thomas

2013-01-01

, we find that interdependency across business units may result in more, not less, decentralization. Furthermore, even though centralization results in less information, centralized licensing deals are larger. Our model conforms to the existing evidence that reports heterogeneity across firms in both......Technology licensing is an important means for companies to extract more value from their intellectual assets. We build a model that helps understand how licensing activity should be organized within large corporations. More specifically, we compare decentralization—where the business unit using...... the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend on product market performance. If licensing is decentralized, the business unit forgoes valuable...

Aseismic Design Licensings and guidelines for nuclear power plant in Japan

Energy Technology Data Exchange (ETDEWEB)

Yoshizawa, Kazumi [Agency of Natural Resources and Energy, Tokyo (Japan)

1997-03-01

This paper describes Aseismic Design Licensing for Japanese Nuclear Power Plants which includes system, procedures and brief contents concerned application, permit and inspection, and the `Examination Guide for Aseismic Design of the Nuclear Power Reactor Facilities` which focused principals of seismic design loads, load combinations, and allowable limits. (J.P.N.)

Aseismic Design Licensings and guidelines for nuclear power plant in Japan

International Nuclear Information System (INIS)

Yoshizawa, Kazumi

1997-01-01

This paper describes Aseismic Design Licensing for Japanese Nuclear Power Plants which includes system, procedures and brief contents concerned application, permit and inspection, and the 'Examination Guide for Aseismic Design of the Nuclear Power Reactor Facilities' which focused principals of seismic design loads, load combinations, and allowable limits. (J.P.N.)

10 CFR 51.107 - Public hearings in proceedings for issuance of combined licenses; limited work authorizations.

Science.gov (United States)

2010-01-01

... resolved in the early site permit proceeding; or (3) Raises any issue involving the impacts of construction... license hearing shall not admit contentions proffered by any party concerning severe accident mitigation... construction and operation of a nuclear power plant, and a construction permit was issued but construction of...

7 CFR 6.28 - Transfer of license.

Science.gov (United States)

2010-01-01

... Licensing Authority will transfer to such other person the historical, nonhistorical or designated license... escrow with the sole condition for return of escrow being that the Licensing Authority determines that... to whom the historical licenses were issued during the quota year in which the sale or conveyance...

Free Software Licenses and Other Free Licenses: Genetic Code of Digital Common Goods

Directory of Open Access Journals (Sweden)

Marco Ciurcina

2017-06-01

Full Text Available This article explores the history and describes the main features of free software licenses and other free licenses in an attempt to shed light on the reasons for their success in promoting individual behaviors converging towards the collective construction of digital commons.

Negative royalty in duopoly and definition of license fee: general demand and cost functions

OpenAIRE

Hattori, Masahiko; Tanaka, Yasuhito

2017-01-01

We examine the relationship between the definition of license fee and a possibility of negative royalty in a duopoly with an outside innovator which has an option to enter the market and imposes a combination of a royalty per output and a fixed fee under general demand and cost functions. We consider two scenarios about determination of license fee. One is a scenario which does not assume entry of the innovator, and the other is a scenario which takes a possibility of entry of the innovator i...

Technology neutral licensing requirements: have we been successful?

International Nuclear Information System (INIS)

Jamieson, T.

2009-01-01

The Canadian Nuclear Safety Commission (CNSC) is Canada's nuclear regulator. In preparation for the licensing of the next generation of nuclear reactors in Canada, the CNSC has made major changes in its processes and procedures associated with all aspects of the licensing life cycle. These include: development of key regulatory documents outlining the CNSC expectations for the design and siting of new reactors; creation of applicant guidelines for completing licensing applications; creation of a comprehensive set of review guides, specifying how topics in applications are to be reviewed; performing pre-project design reviews for proposed new reactor technologies; and streamlining processes wherever possible, such as performing the environmental assessment and license to prepare site activities in parallel. The predicted workload associated with the nuclear renaissance in Canada is real. The CNSC is currently performing: 4 pre-project design reviews (for AECL's ACR-1000 and EC-6, Areva's EPR and Westinghouse's AP-1000), has received applications for 4 new builds (at Darlington, Bruce, Nanticoke and in Alberta) and is in the midst of performing the combined environmental assessment and license to prepare site phases for these sites. This is in addition to the work associated with: the licensing of new uranium mines; oversight of the existing reactor fleet; refurbishments at Bruce/Gentilly/Point Lepreau; license renewal for the NRU reactor; and oversight of our general client base of over 5000 licensees. In this presentation, experience to date with these new processes and procedures will be discussed, including: status of the current new build projects; anticipated new activities; lessons learned, especially the technology neutral approach; application to our other licensed activities, including non-power reactors; and work underway to further develop CNSC methods. Qualifications Needed to Design, Construct and Manufacture Nuclear Systems and Equipment, C. Voutsinos

Licensing Teachers: Lessons from Other Professions.

Science.gov (United States)

Haberman, Martin

1986-01-01

The licensing of teachers should be modeled against professions similar to teaching rather than professions like medicine and architecture that are vastly different. Applying similar licensing practices can raise the status of teaching. Ignoring these licensing practices will prevent teachers from functioning as professionals. (MD)

Licensing of nuclear and radioactive installations in Peru

International Nuclear Information System (INIS)

Medina Gironzini, E.

1987-01-01

In Peru, the Regulation for Ionizing Radiation Sources is applied, which establishes the norms and procedures to follow in the nuclear and radioactive installations of the country in order to assure their correct operation as concerns to the nuclear safety and radiological protection, allowing the emission of the respective licenses. As for the nuclear facilities, this authorization includes the Previous License, the Construction License and the Operation License (provisional and definitive) and for radioactive facilities and equipment generating ionizing radiations: the Construction License and the Operation License. The personnel also require a license that can be an operator license (as for nuclear reactors) or a supervisor license (for nuclear and radioactive facilities). In spite of the above mentioned regulation and its long enforcement period, less than 10% of radioactive facilities in this country are licensed, due to different problems which will be solved in the medium term. (Author)

The licensing processes influence on nuclear market

International Nuclear Information System (INIS)

Locatelli, Giorgio; Mancini, Mauro; Sainati, Tristano; Sallinen, Liisa

2011-01-01

The paper deals with the licensing nuclear power plants; it focuses primarily on the licensing process implications into the international nuclear market. Nowadays there are twenty-six countries that are planning to build new nuclear facilities, and thirty-seven where nuclear reactors are proposed; on the other hand, there are mainly ten international reactor vendors. At international level, there are few vendors that have sufficient resources, capabilities and experience to carry out the design and delivering of a nuclear power plant in the international market; On the other hand, the licensing processes are strictly dependent on national law frameworks, and on the nuclear policies. The paper proposes a comparison of six licensing processes (the ones established in Finland, France, Italy, South Korea, USA and UK), and analyzes its main features and implications; the IAEA licensing process is taken as reference point. The objective of the paper is to propose a systemic approach for considering the licensing procedures. The framework proposed enables facilitating the licensing management and inferring the main features of licensing contexts. The paper concludes with a forecast of the nuclear licensing context, especially with respect to the fourth generation of nuclear reactors. (author)

Whom to Choose as License Partner?

DEFF Research Database (Denmark)

Laursen, Keld; Reichstein, Toke; Trombini, Giulia

2013-01-01

between technology and market forces: if partners are market distant, the likelihood of technology license contractual partnership decreases with partners’ technological distance. Using data on the formation of license partnerships in the global biopharmaceutical industry over the period 1994......This paper investigates the matching of firms on the market for technology. The paper forwards two dimensions along which license formation occurs: technology and product-market. Both sides of the market search for a partner representing potential for high technology synergies to maximize licensing...

Pre-licensed driving experience and car crash involvement during the learner and restricted, licence stages of graduated driver licensing: Findings from the New Zealand drivers study.

Science.gov (United States)

Begg, Dorothy J; Langley, John D; Brookland, Rebecca L; Ameratunga, Shanthi; Gulliver, Pauline

2014-01-01

The aim of this study was to determine whether pre-licence driving experiences, that is driving before beginning the licensing process, increased or decreased crash risk as a car driver, during the learner or the restricted licence stages of the graduated driver licensing system (GDLS). Study participants were 15-24 year old members of the New Zealand Drivers Study (NZDS) - a prospective cohort study of newly licensed car drivers. The interview stages of the NZDS are linked to, the three licensing stages of the GDLS: learner, restricted and full. Baseline demographic (age, ethnicity, residential location, deprivation), personality (impulsivity, sensation seeking, aggression) and, behavioural data, (including pre-licensed driving behaviour), were obtained at the learner licence interview. Data on distance driven and crashes that occurred at the learner licence and restricted licence stages, were reported at the restricted and full licence interviews, respectively. Crash data were also obtained from police traffic crash report files and this was combined with the self-reported crash data. The analysis of the learner licence stage crashes, when only supervised driving is allowed, was based on the participants who had passed the restricted licence test and undertaken the NZDS, restricted licence interview (n=2358). The analysis of the restricted licence stage crashes, when unsupervised driving is first allowed, was based on those who had passed the full licence test and completed the full licence interview (n=1428). After controlling for a range of demographic, personality, behavioural variables and distance driven, Poisson regression showed that the only pre-licence driving behaviour that showed a consistent relationship with subsequent crashes was on-road car driving which was associated with an increased risk of being the driver in a car crash during the learner licence period. This research showed that pre-licensed driving did not reduce crash risk among learner or

Exporting the Canadian licensing program

International Nuclear Information System (INIS)

Whelan, D.J.

1981-06-01

This paper deals with the problems of an overseas regulatory agency in licensing a Canadian-supplied nuclear plant which is referenced to a plant in Canada. Firstly, the general problems associated with the use of a reference plant are discussed. This is followed by a discussion of specific problems which arise from the licensing practices in Canada. The paper concludes with recommendations to simplify the task of demonstrating the licensability of an overseas CANDU plant

7 CFR 6.32 - Globalization of licenses.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Globalization of licenses. 6.32 Section 6.32 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.32 Globalization of licenses. If the Licensing Authority determines that entries of an article...

42 CFR 431.710 - Provisional licenses.

Science.gov (United States)

2010-10-01

... Licensing Nursing Home Administrators § 431.710 Provisional licenses. To fill a position of nursing home... 42 Public Health 4 2010-10-01 2010-10-01 false Provisional licenses. 431.710 Section 431.710 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

Product Licenses Database Application

CERN Document Server

Tonkovikj, Petar

2016-01-01

The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

Licensing plan for UMTRA project disposal sites

International Nuclear Information System (INIS)

1993-09-01

The Uranium Mill Tailings Remedial Action (UMTRA) Project Office developed a plan to define UMTRA Project licensing program objectives and establish a process enabling the DOE to document completion of remedial actions in compliance with 40 CFR 1 92 and the requirements of the NRC general license. This document supersedes the January 1987 Project Licensing Plan (DOE, 1987). The plan summarizes the legislative and regulatory basis for licensing, identifies participating agencies and their roles and responsibilities, defines key activities and milestones in the licensing process, and details the coordination of these activities. This plan provides an overview of the UMTRA Project from the end of remedial actions through the NRC's acceptance of a disposal site under the general license. The licensing process integrates large phases of the UMTRA Project. Other programmatic UMTRA Project documents listed in Section 6.0 provide supporting information

Nuclear facilities licensing

International Nuclear Information System (INIS)

Carvalho, A.J.M. de.

1978-01-01

The need for the adoption of a legal and normative system, defining objectives, pescriptions and the process of nuclear licensing and building of nuclear power plants in Brazil is enphasized. General rules for the development of this system are presented. The Brazilian rules on the matter are discussed. A general view of the German legal system for nuclear power plant licensing and the IAEA recommendations on the subject are finally presented. (A.L.S.L.) [pt

To License or Not to License: An Examination of State Statutes Regarding Private Investigators and Digital Examiners

Directory of Open Access Journals (Sweden)

Thomas Lonardo

2008-09-01

Full Text Available In this paper the authors examine statutes that regulate, license, and enforce investigative functions in each US state. After identification and review of Private Investigator licensing requirements, the authors find that very few state statutes explicitly differentiate between Private Investigators and Digital Examiners. After contacting all state agencies the authors present a distinct grouping organizing state approaches to professional Digital Examiner licensing. The authors conclude that states must differentiate between Private Investigator and Digital Examiner licensing requirements and oversight.

Operating reactors licensing actions summary

International Nuclear Information System (INIS)

1981-08-01

The Operating Reactors Licensing Actions Summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors

77 FR 71404 - Notice of Intent to License Government-Owned Inventions; Intent to License on a Partially...

Science.gov (United States)

2012-11-30

... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent to License Government-Owned Inventions; Intent to License on a Partially-Exclusive Basis AGENCY: Department of the Army, DoD. ACTION... by the Secretary of the Army. The US Army Edgewood Chemical Biological Center intends to license...

Licensing of ''grandfather's'' facilities: Ukrainian experience

International Nuclear Information System (INIS)

Mikolaitchouk, H.; Bogdan, L.; Steinberg, N.

1995-01-01

In the former USSR, unlike most countries, radioactive waste management activities including waste disposal needed no license. But after the USSR breakdown the Ukrainian Parliament -- Verkhovna Rada -- invoked the revised Law on Business activities. According to Article 4 of the Law, in order to treat or to dispose radioactive waste every enterprise has to get a special permission or license. In compliance with the Law, the Cabinet of Ministers by its Ordinance of January 13, 1993, authorized the Ukrainian State Committee for Nuclear and Radiation Safety (UkrSCNRS) to issue special permissions or licenses for waste treatment and disposal. And that requirement was valid not only for future activities but also for existing facilities in operation. Taking into account the undergoing legislative process, SCNRS began to develop its licensing process without waiting for the special nuclear laws to be passed. On the basis of the legislation already in effect, first of all the Law on Enterprises (full responsibility of enterprises for their activities) and Law on Business activities (requirement to have a license for special types of activities), the newly formed national regulatory body had to identify all the enterprises that needed to be licensed, to establish relevant procedures, to develop related regulatory documents, to implement these procedures and documents at operating enterprises, and for each case to make a decision concerning feasibility of issuing a license, period of validity and license conditions

Analysis of CO2 draining in the supercritical subchannel of an MMR reactor using CFD techniques

International Nuclear Information System (INIS)

Dutra, Carolina S.B.; Ribeiro, Felipe P.; Su, Jian

2017-01-01

This work aims to analyze the steady state thermal hydraulic behavior of the supercritical CO 2 by means of the computational modeling of the triangular arrangement subchannel of the KAIST MMR (Korea Advanced Institute of Science and Technology). The mathematical model is composed of Navier-Stokes equations of Reynolds average (RANS), with the model of turbulence k-omega SST (Shear Stress Transport) for the fluid refrigerant in the subchannel and the heat conduction equation for the fuel and coating. The thermodynamic properties of CO 2 are implemented from National Institute of Standards and Technology (NIST) data. The transport equations were solved using a commercial CFD (Fluid Dynamics) tool, ANSYS FLUENT. Initially, a geometric model was constructed, using the ICEM software, composed of fuel, interstice, coating, refrigerant and two adiabatic regions of the fuel rod. The numerical solution used was validated by simulation of a simpler vertical circular tube and by comparisons with numerical and experimental results available in the literature. Using these results, we performed the mesh convergence study and initialized the simulations in the subchannel

Sensitivity analysis using the FRAPCON-1/EM: development of a calculation model for licensing

International Nuclear Information System (INIS)

Chapot, J.L.C.

1985-01-01

The FRAPCON-1/EM is version of the FRAPCON-1 code which analyses fuel rods performance under normal operation conditions. This version yields conservative results and is used by the NRC in its licensing activities. A sensitivity analysis was made, to determine the combination of models from the FRAPCON-1/EM which yields the most conservative results for a typical Angra-1 reactor fuel rod. The present analysis showed that this code can be used as a calculation tool for the licensing of the Angra-1 reload. (F.E.) [pt

Review process for license renewal applications

International Nuclear Information System (INIS)

Craig, John W.; Kuo, P.T.

1991-01-01

In preparation for license renewal reviews, the Nuclear Regulatory Commission has recently published for public review and comment a proposed rule for license renewal and a draft Standard Review Plan as well as a draft Regulatory Guide relating to the implementation of the proposed rule. In support of future license renewal applications, the nuclear industry has also submitted 11 industry reports for NRC review and approval. This paper briefly describe how these parallel regulatory and industry activities will be factored into the NRC review process for license renewal. (author)

10 CFR 781.51 - Nonexclusive licenses.

Science.gov (United States)

2010-01-01

... corporate structure of which licensee is a part, if any. However, the license shall not be assignable or... license upon the policies of the United States Government; (3) The effect of the license upon domestic and... extent of U.S. Government contribution to the development of the invention; (iv) The degree of...

7 CFR 6.33 - License fee.

Science.gov (United States)

2010-01-01

... certified mail, return receipt requested, advising the licensee that if payment is not mailed in accordance.... Where the license at issue is a historical license, this will result, pursuant to § 6.23(b), in the person's loss of historical eligibility for such license. (d) Licensees may elect not to accept certain...

Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing.

Science.gov (United States)

Buchanan, Daniel D; Tan, Yen Y; Walsh, Michael D; Clendenning, Mark; Metcalf, Alexander M; Ferguson, Kaltin; Arnold, Sven T; Thompson, Bryony A; Lose, Felicity A; Parsons, Michael T; Walters, Rhiannon J; Pearson, Sally-Ann; Cummings, Margaret; Oehler, Martin K; Blomfield, Penelope B; Quinn, Michael A; Kirk, Judy A; Stewart, Colin J; Obermair, Andreas; Young, Joanne P; Webb, Penelope M; Spurdle, Amanda B

2014-01-10

Clinicopathologic data from a population-based endometrial cancer cohort, unselected for age or family history, were analyzed to determine the optimal scheme for identification of patients with germline mismatch repair (MMR) gene mutations. Endometrial cancers from 702 patients recruited into the Australian National Endometrial Cancer Study (ANECS) were tested for MMR protein expression using immunohistochemistry (IHC) and for MLH1 gene promoter methylation in MLH1-deficient cases. MMR mutation testing was performed on germline DNA of patients with MMR-protein deficient tumors. Prediction of germline mutation status was compared for combinations of tumor characteristics, age at diagnosis, and various clinical criteria (Amsterdam, Bethesda, Society of Gynecologic Oncology, ANECS). Tumor MMR-protein deficiency was detected in 170 (24%) of 702 cases. Germline testing of 158 MMR-deficient cases identified 22 truncating mutations (3% of all cases) and four unclassified variants. Tumor MLH1 methylation was detected in 99 (89%) of 111 cases demonstrating MLH1/PMS2 IHC loss; all were germline MLH1 mutation negative. A combination of MMR IHC plus MLH1 methylation testing in women younger than 60 years of age at diagnosis provided the highest positive predictive value for the identification of mutation carriers at 46% versus ≤ 41% for any other criteria considered. Population-level identification of patients with MMR mutation-positive endometrial cancer is optimized by stepwise testing for tumor MMR IHC loss in patients younger than 60 years, tumor MLH1 methylation in individuals with MLH1 IHC loss, and germline mutations in patients exhibiting loss of MSH6, MSH2, or PMS2 or loss of MLH1/PMS2 with absence of MLH1 methylation.

25 CFR 11.601 - Marriage licenses.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Marriage licenses. 11.601 Section 11.601 Indians BUREAU... ORDER CODE Domestic Relations § 11.601 Marriage licenses. A marriage license shall be issued by the clerk of the court in the absence of any showing that the proposed marriage would be invalid under any...

Meta-analysis of graduated driver licensing laws: effectiveness of specific program components : traffic tech.

Science.gov (United States)

2015-11-01

Graduated driver licensing (GDL) programs in the United States do not represent a single homogeneous intervention; rather, they contain different combinations and variations of program components. Programs vary by the duration of each stage of the GD...

The optimal licensing contract in a differentiated Stackelberg model.

Science.gov (United States)

Hong, Xianpei; Yang, Lijun; Zhang, Huaige; Zhao, Dan

2014-01-01

This paper extends the work of Wang (2002) by considering a differentiated Stackelberg model, when the leader firm is an inside innovator and licenses its new technology by three options, that is, fixed-fee licensing, royalty licensing, and two-part tariff licensing. The main contributions and conclusions of this paper are threefold. First of all, this paper derives a very different result from Wang (2002). We show that, with a nondrastic innovation, royalty licensing is always better than fixed-fee licensing for the innovator; with a drastic innovation, royalty licensing is superior to fixed-fee licensing for small values of substitution coefficient d; however when d becomes closer to 1, neither fee nor royalty licensing will occur. Secondly, this paper shows that the innovator is always better off in case of two-part tariff licensing than fixed-fee licensing no matter what the innovation size is. Thirdly, the innovator always prefers to license its nondrastic innovation by means of a two-part tariff instead of licensing by means of a royalty; however, with a drastic innovation, the optimal licensing strategy can be either a two-part tariff or a royalty, depending upon the differentiation of the goods.

AVC/H.264 patent portfolio license

Science.gov (United States)

Skandalis, Dean A.

2006-08-01

MPEG LA, LLC offers a joint patent license for the AVC (a/k/a H.264) Standard (ISO/IEC IS 14496-10:2004). Like MPEG LA's other licenses, the AVC Patent Portfolio License is offered for the convenience of the marketplace as an alternative enabling users to access essential intellectual property owned by many patent holders under a single license rather than negotiating licenses with each of them individually. The AVC Patent Portfolio License includes essential patents owned by DAEWOO Electronics Corporation; Electronics and Telecommunications Research Institute (ETRI); France Telecom, societe anonyme; Fujitsu Limited; Hitachi, Ltd.; Koninklijke Philips Electronics N.V.; LG Electronics Inc.; Matsushita Electric Industrial Co., Ltd.; Microsoft Corporation; Mitsubishi Electric Corporation; Robert Bosch GmbH; Samsung Electronics Co., Ltd.; Sedna Patent Services, LLC; Sharp Kabushiki Kaisha; Siemens AG; Sony Corporation; The Trustees of Columbia University in the City of New York; Toshiba Corporation; UB Video Inc.; and Victor Company of Japan, Limited. Another is expected also to join as of August 1, 2006. MPEG LA's objective is to provide worldwide access to as much AVC essential intellectual property as possible for the benefit of AVC users. Therefore, any party that believes it has essential patents is welcome to submit them for evaluation of their essentiality and inclusion in the License if found essential.

Towards a standard licensing scheme for the access and use of satellite earth observation data for disaster management

Science.gov (United States)

Clark, Nathan E.

2017-10-01

This paper explores from the view of the data recipient and user the complexities of creating a common licensing scheme for the access and use of satellite earth observation (EO) data in international disaster management (DM) activities. EO data contributions in major disaster events often involve numerous data providers with separate licensing mechanisms for controlling the access, uses, and distribution of data by the end users. A lack of standardization among the terminology, wording, and conditions within these licenses creates a complex legal environment for users, and often prevents them from using, sharing and combining datasets in an effective and timely manner. It also creates uncertainty among data providers as to the types of licensing controls that should be applied in disaster scenarios. This paper builds from an ongoing comparative analysis of the common and conflicting conditions among data licenses that must be addressed in order to facilitate easier access and use of EO data within the DM sector and offers recommendations towards the alignment of the structural and technical aspects of licenses among data providers.

The Optimal Licensing Contract in a Differentiated Stackelberg Model

Directory of Open Access Journals (Sweden)

Xianpei Hong

2014-01-01

Full Text Available This paper extends the work of Wang (2002 by considering a differentiated Stackelberg model, when the leader firm is an inside innovator and licenses its new technology by three options, that is, fixed-fee licensing, royalty licensing, and two-part tariff licensing. The main contributions and conclusions of this paper are threefold. First of all, this paper derives a very different result from Wang (2002. We show that, with a nondrastic innovation, royalty licensing is always better than fixed-fee licensing for the innovator; with a drastic innovation, royalty licensing is superior to fixed-fee licensing for small values of substitution coefficient d; however when d becomes closer to 1, neither fee nor royalty licensing will occur. Secondly, this paper shows that the innovator is always better off in case of two-part tariff licensing than fixed-fee licensing no matter what the innovation size is. Thirdly, the innovator always prefers to license its nondrastic innovation by means of a two-part tariff instead of licensing by means of a royalty; however, with a drastic innovation, the optimal licensing strategy can be either a two-part tariff or a royalty, depending upon the differentiation of the goods.

Licensing and advanced fuel designs

International Nuclear Information System (INIS)

Davidson, S.L.; Novendstern, E.H.

1991-01-01

For the past 15 years, Westinghouse has been actively involved in the development and licensing of fuel designs that contain major advanced features. These designs include the optimized fuel assembly, The VANTAGE 5 fuel assembly, the VANTAGE 5H, and most recently the VANTAGE+ fuel assembly. Each of these designs was supported by extensive experimental data, safety evaluations, and design efforts and required intensive interaction with the US Nuclear Regulatory Commission (NRC) during the review and approval process. This paper presents a description of the licensing approach and how it was utilized by the utilities to facilitate the licensing applications of the advanced fuel designs for their plants. The licensing approach described in this paper has been successfully applied to four major advanced fuel design changes ∼40 plant-specific applications, and >350 cycle-specific reloads in the past 15 years

Nuclear licensing in Slovenia

International Nuclear Information System (INIS)

Prah, M.; Spiler, J.; Vojnovic, D.; Pristavec, M.

1998-01-01

The article presents the approach to nuclear licensing in Slovenia. The paper describes, the initialization, internal authorization and review process in the Krsko NPP. The overall process includes preparation, internal independent evaluation, the Krsko Operating Committee and the Krsko Safety Committee review and internal approval. In addition, the continuation of the licensing process is discussed which includes independent evaluation by an authorized institution and a regulatory body approval process. This regulatory body approval process includes official hearing of the licensee, communication with the licensee, and final issuance of a license amendment. The internal evaluation, which follows the methodology of US NRC (defined in 10 CFR 50.59 and NUMARC 125) is described. This concept is partially implemented in domestic legislation.(author)

Regulatory guidance for license renewal

International Nuclear Information System (INIS)

Thoma, John A.

1991-01-01

The proposed 10 CFR Part 54 rule proceduralizes the process for license renewal by identifying both the administrative and technical requirements for a renewal application. To amplify and support this regulation, written guidance has been provided in the form of a draft Regulatory Guide (DG 1009) and a draft Standard Review Plan for License Renewal (NUREG 1299). This guidance is scheduled to be finalized in 1992. Similar guidance will be provided for the proposed revisions to 10 CFR Part 51 concerning the environmental aspects of license renewal. (author)

Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome).

Science.gov (United States)

Buchanan, Daniel D; Rosty, Christophe; Clendenning, Mark; Spurdle, Amanda B; Win, Aung Ko

2014-01-01

Carriers of a germline mutation in one of the DNA mismatch repair (MMR) genes have a high risk of developing numerous different cancers, predominantly colorectal cancer and endometrial cancer (known as Lynch syndrome). MMR gene mutation carriers develop tumors with MMR deficiency identified by tumor microsatellite instability or immunohistochemical loss of MMR protein expression. Tumor MMR deficiency is used to identify individuals most likely to carry an MMR gene mutation. However, MMR deficiency can also result from somatic inactivation, most commonly methylation of the MLH1 gene promoter. As tumor MMR testing of all incident colorectal and endometrial cancers (universal screening) is becoming increasingly adopted, a growing clinical problem is emerging for individuals who have tumors that show MMR deficiency who are subsequently found not to carry an MMR gene mutation after genetic testing using the current diagnostic approaches (Sanger sequencing and multiplex ligation-dependent probe amplification) and who also show no evidence of MLH1 methylation. The inability to determine the underlying cause of tumor MMR deficiency in these "Lynch-like" or "suspected Lynch syndrome" cases has significant implications on the clinical management of these individuals and their relatives. When the data from published studies are combined, 59% (95% confidence interval [CI]: 55% to 64%) of colorectal cancers and 52% (95% CI: 41% to 62%) of endometrial cancers with MMR deficiency were identified as suspected Lynch syndrome. Recent studies estimated that colorectal cancer risk for relatives of suspected Lynch syndrome cases is lower than for relatives of those with MMR gene mutations, but higher than for relatives of those with tumor MMR deficiency resulting from methylation of the MLH1 gene promoter. The cause of tumor MMR deficiency in suspected Lynch syndrome cases is likely due to either unidentified germline MMR gene mutations, somatic cell mosaicism, or biallelic somatic

Licensing issues

International Nuclear Information System (INIS)

Roberts, J.P.; Desell, L.J.; Birch, M.L.; Berkowitz, L.; Bader, J.F.

1992-01-01

To provide guidance for the Department of Energy's (DOE) Civilian Radioactive Waste Management Program, the Nuclear Regulatory Commission (NRC) has issued a draft regulatory guide on the Format and Content for the License Application for the High-Level Waste Repository (FCRG). To facilitate the development of the FCRG, NRC suggested that DOE use the draft guide as the basis for preparing an annotated outline for a license application. DOE is doing so using an iterative process called the Annotated Outline Initiative. DOE;s use of the Initiative will assist in achieving the desired incorporation of actual experience in the FCRG, contribute to the development of shared interpretation and understanding of NRC regulations, and provide other important programmatic benefits described in this paper

78 FR 17450 - Notice of Issuance of Materials License Renewal, Operating License SUA-1341, Uranium One USA, Inc...

Science.gov (United States)

2013-03-21

... License Renewal, Operating License SUA-1341, Uranium One USA, Inc., Willow Creek Uranium In Situ Recovery.... SUA- 1341 to Uranium One USA, Inc. (Uranium One) for its Willow Creek Uranium In Situ Recovery (ISR... Commission License No. SUA-1341 For Uranium One USA, Inc., Irigaray and Christensen Ranch Projects (Willow...

78 FR 5840 - Notice of License Termination for University of Illinois Advanced TRIGA Reactor, License No. R-115

Science.gov (United States)

2013-01-28

... University of Illinois Advanced TRIGA Reactor, License No. R-115 The U.S. Nuclear Regulatory Commission (NRC) is noticing the termination of Facility Operating License No. R-115, for the University of Illinois... Operating License No. R-115 is terminated. The above referenced documents may be examined, and/or copied for...

The USNCR license renewal process

International Nuclear Information System (INIS)

Kuo, Pao-Tsin

2002-01-01

The US Congress promulgated a law in 1954, entitled 'Atomic Energy Act'. This Act states that operating licenses for commercial nuclear power plants are limited to a fixed term of 40 years, but they may be renewed for a period not to exceed 20 years. The terms were established mainly for economic considerations, not based on technical limitations. The U.S. Nuclear Regulatory Commission (USNRC) published the license renewal rule, Title 10 of the Code of Federal Regulations, Part 54 (10 CFR Part 54), in December, 1991. The rule has since been amended in May, 1995. The underlying principle of the rule is that the regulatory process is adequate for ensuring safety of operating plants. The regulatory process includes NRC's issuance of Orders, Bulletins, Generic Letters, and Information Notices, as well as a number of special inspections in addition to the continuous oversight and routine inspection activities performed by on-site inspectors. Because of this comprehensive regulatory process, compilation of the current license basis or re-verification of the current licensing basis is not considered necessary for a license renewal review. The USNRC also determined on the basis of the findings of its research programs that active structures and components are well maintained by the existing programs. Therefore, the focus of the license renewal review is on passive, long-lived structures and components and on time-limited ageing analyses. The time-limited ageing analyses are for those structures and components which were originally designed to a 40 year service life

Dry spent fuel storage licensing

International Nuclear Information System (INIS)

Sturz, F.C.

1995-01-01

In the US, at-reactor-site dry spent fuel storage in independent spent fuel storage installations (ISFSI) has become the principal option for utilities needing storage capacity outside of the reactor spent fuel pools. Delays in the geologic repository operational date at or beyond 2010, and the increasing uncertainty of the US Department of Energy's (DOE) being able to site and license a Monitored Retrievable Storage (MRS) facility by 1998 make at-reactor-site dry storage of spent nuclear fuel increasingly desirable to utilities and DOE to meet the need for additional spent fuel storage capacity until disposal, in a repository, is available. The past year has been another busy year for dry spent fuel storage licensing. The licensing staff has been reviewing 7 applications and 12 amendment requests, as well as participating in inspection-related activities. The authors have licensed, on a site-specific basis, a variety of dry technologies (cask, module, and vault). By using certified designs, site-specific licensing is no longer required. Another new cask has been certified. They have received one new application for cask certification and two amendments to a certified cask design. As they stand on the brink of receiving multiple applications from DOE for the MPC, they are preparing to meet the needs of this national program. With the range of technical and licensing options available to utilities, the authors believe that utilities can meet their need for additional spent fuel storage capacity for essentially all reactor sites through the next decade

A meta-analytic review of moral licensing.

Science.gov (United States)

Blanken, Irene; van de Ven, Niels; Zeelenberg, Marcel

2015-04-01

Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397 participants) that compare a licensing condition with a control condition. Based on this analysis, the magnitude of the moral licensing effect is estimated to be a Cohen's d of 0.31. We tested potential moderators and found that published studies tend to have larger moral licensing effects than unpublished studies. We found no empirical evidence for other moderators that were theorized to be of importance. The effect size estimate implies that studies require many more participants to draw solid conclusions about moral licensing and its possible moderators. © 2015 by the Society for Personality and Social Psychology, Inc.

PBMR-SA licensing project organization

International Nuclear Information System (INIS)

Clapisson, G.A.; Metcalf, P.E.; Mysen, A.

2001-01-01

The South African nuclear regulatory authority, the Council for Nuclear Safety (CNS), is beginning the safety review of the Pebble Bed Modular Reactor (PBMR) design under development by the South African National Electrical Utility, Eskom. This paper describes the CNS licensing process, including the establishment of basic licensing criteria, general design criteria, and specific design rules, as well the safety assessment to be conducted in accordance with the established structure. It also summarises the CNS PBMR review project activities, including the overall organisational arrangements, licensing basis, safety and risk assessment, general operating rules and plant design engineering, and pre-operational testing. (author)

76 FR 81992 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

Science.gov (United States)

2011-12-29

... License Application for Bell Bend Nuclear Power Plant; Exemption 1.0 Background PPL Bell Bend, LLC... for Nuclear Power Plants.'' This reactor is to be identified as Bell Bend Nuclear Power Plant (BBNPP... based upon the U.S. EPR reference COL (RCOL) application for UniStar's Calvert Cliffs Nuclear Power...

An introduction to intellectual property licensing for technology companies

Science.gov (United States)

Meier, Lawrence H.

2001-05-01

Intellectual property licensing is an important issue facing all technology companies. Before entering into license agreements a number of issues need to be addressed, including invention ownership, obtaining and identifying licensable subject matter, and developing a licensing strategy. There are a number of important provisions that are included in most intellectual property license agreements. These provisions include definitions, the license grant, consideration, audit rights confidentiality, warranties, indemnification, and limitation of liability. Special licensing considerations exist relative to each type of intellectual property, and when the other party is a foreign company or a university.

75 FR 55799 - Government-Owned Inventions; Availability for Licensing

Science.gov (United States)

2010-09-14

... licensing. Licensing Contact: Patrick P. McCue, PhD, (301) 435-5560; [email protected] . Collaborative... Reference No. E-051-2010/0-US-01). Licensing Status: Available for licensing. Licensing Contact: Patrick P... for the brain tumors or brain cancers indentified as gliomas, glioblastomas, or astrocytomas. This...

77 FR 47393 - Ocean Transportation Intermediary License Revocations

Science.gov (United States)

2012-08-08

...: Voluntary surrender of license. License No.: 12454N. Name: Federation Exports-Imports Inc. Address: 747...: Natco International Transports USA, L.L.C. Address: 12415 SW 136th Avenue, Bay 4, Miami, FL 33186 Date...: Voluntary surrender of license. License No.: 022773F. Name: WLI (USA) Inc. Address: 175-01 Rockaway Blvd...

License renewal - an idea whose time has come. Hatch nuclear plant license renewal program: an actual example of application of the license renewal rule to the Intake Structure

International Nuclear Information System (INIS)

Chandiwala, F.; Evans, W.P.

1999-01-01

After the NRC issued a revised license renewal rule in May 1995, the nuclear industry focussed on developing generic industry for implementing the rule and testing the guidance through various demonstration programs and work products in conjunction with the NRC. In addition, plant-specific programs also proceeded forward. These activities show that implementation issues continue to exist. Since the issuance of the rule, the NRC has issued a draft standard review plan for license renewal (SRP-LR), working draft, September 1997. Southern Nuclear Operating Company (SNC) has begun development work on a license renewal application for Plant Hatch Units 1 and 2. Plant Hatch Units 1 and 2 are BWR 4, Mark I plants whose operating licenses expire in 2014 and 2018, respectively. The Plant Hatch initiative also involves teaming with other boiling water reactors (BWRs) to develop the license renewal technology within the BWR fleet, and to support Plant Hatch by providing an oversight role for the application process. The teaming effort involved two other utilities, each being assigned to prepare a common report on a mechanical system or a structure. The common report could be presented to the NRC with modifications to suit the individual plants, thereby saving time and money, and hopefully resulting in quicker approval by the NRC. The desired license renewal process end result is a renewed license with up to a 20 year extension (10CFR 54.31(b)). (orig.)

14 CFR 1245.108 - License to contractor.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false License to contractor. 1245.108 Section... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.108 License to contractor. (a) Each contractor.... The license extends to the contractor's domestic subsidiaries and affiliates, if any, within the...

License protection with a tamper-resistant token

NARCIS (Netherlands)

Chong, C.N.; Ren, Bin; Doumen, J.M.; Etalle, Sandro; Hartel, Pieter H.; Corin, R.J.; Lim, Chae Hoon; Yung, Moti

Content protection mechanisms are intended to enforce the usage rights on the content. These usage rights are carried by a license. Sometimes, a license even carries the key that is used to unlock the protected content. Unfortunately, license protection is difficult, yet it is important for digital

Trends in CANDU licensing

International Nuclear Information System (INIS)

Snell, V.G.; Grant, S.D.

1997-01-01

Modern utilities view nuclear power more and more as a commodity - it must compete 'today' with current alternatives to attract their investment. With its long construction times and large capital investment, nuclear plants are vulnerable to delays once they have been committed. There are two related issues. Where the purchaser and the regulator are experienced in CANDU, the thrust is a very practical one: to identify and resolve major licensing risks at a very early stage in the project. Thus for a Canadian project, the designer (AECL) and the prospective purchaser would deal directly with the AECB. However CANDU has also been successfully licensed in other countries, including Korea, Romania, Argentina, India and Pakistan. Each of these countries has its own regulatory agency responsible for licensing the plant. In addition, however, the foreign customer and regulator may seek input from the AECB, up to and including a statement of licensability in Canada; this is not normally needed for a ''repeat'' plant and/or if the customer is experienced in CANDU, but can be requested if the plant configuration has been modified significantly from an already-operating CANDU. It is thus the responsibility of the designer to initiate early discussions with the AECB so the foreign CANDU meets the expectations of its customers

47 CFR 97.5 - Station license required.

Science.gov (United States)

2010-10-01

.... (3) A military recreation station license grant. A military recreation station license grant may be... States military recreational premises where the station is situated. The person must not be a... the balance of the license term and the suspension is still in effect, suspended for the balance of...

24 CFR 3286.203 - Installation license required.

Science.gov (United States)

2010-04-01

... performance of the installation work in compliance with the requirements of this part. (3) A license is not required for individuals working as direct employees of a licensed installer or for the company that... and competent performance of all employees working under the licensed installer's supervision and for...

Non-Power Reactor Operator Licensing Examiner Standards

International Nuclear Information System (INIS)

1994-06-01

The Non-Power Reactor Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR Part 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, this standard will be revised periodically to accommodate comments and reflect new information or experience

NPP License Renewal and Aging Management: Revised Guidance

International Nuclear Information System (INIS)

Hull, A.B.; Hiser, A.L.; Lindo-Talin, S.E.

2012-01-01

Based on the Atomic Energy Act, the NRC issues licenses for commercial power reactors to operate for up to 40 years and allows these licenses to be renewed for up to another 20 years. NRC has approved license renewal for well over 50% of U.S. located reactors originally licensed to operate for 40 years. Of these 104 reactors (69 PWRs, 35 BWRs), the NRC has issued renewed licenses for 71 units and is currently reviewing applications for another 15 units. As of May 1, 2012, ten plants at nine sites had entered their 41st year of operation and thus are in their first period of extended operation (PEO). Five more plants will enter the PEO by the end of 2012. One foundation of the license renewal process has been license renewal guidance documents (LRGDs). The U.S. Nuclear Regulatory Commission (NRC) revised key guidance documents used for nuclear power license renewal in 2010 and 2011. These include NUREG-1800, 'Standard Review Plan for Review of License Renewal Applications,' revision 2 (SRP-LR), and NUREG-1801, 'Generic Aging Lessons Learned (GALL) Report,' revision 2 (GALL Report). The guidance documents were updated to reflect lessons learned and operating experience gained since the guidance documents were last issued in 2005. (author)

76 FR 31307 - Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively

Science.gov (United States)

2011-05-31

... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively AGENCY: Department of the Army, DoD. ACTION: Notice. SUMMARY: The... Army. The US Army Edgewood Chemical Biological Center and the US Army Research Laboratory intend to...

Peritumoral granulomatous reaction in endometrial carcinoma: association with DNA mismatch repair protein deficiency, particularly loss of PMS2 expression.

Science.gov (United States)

Stewart, Colin J R; Pearn, Amy; Pachter, Nicholas; Tan, Adeline

2018-04-30

The observation of peritumoral granulomatous reactions (PGRs) in two endometrial carcinomas (ECs) with a PMS2-deficient/MLH1-intact expression pattern led us to investigate whether PGRs in EC were specifically associated with DNA mismatch repair (MMR) protein deficiency, particularly PMS2 loss. Hysterectomy specimens from 22 MMR protein-intact and 54 MMR protein-deficient ECs were reviewed with specific attention to the presence of a PGR and a tumour-associated lymphoid reaction [including tumour-infiltrating lymphocytes (TILs) and stromal lymphoid infiltrates]. The MMR protein-deficient ECs included 22 cases with combined MLH1/PMS2 loss, 11 with combined MSH2/MSH6 loss, 11 with isolated MSH6 loss, and 10 with PMS2 loss but intact MLH1 staining (including the two 'index' cases). Overall, PGRs were identified in seven of 54 (13%) MMR protein-deficient ECs, five of which showed a PMS2-deficient/MLH1-intact immunophenotype; three of these patients had germline PMS2 mutations and one additional patient had a germline MSH6 mutation. None of the MMR protein-intact tumours showed a PGR. Although five of the seven PGR-positive ECs had a high-grade histological component, six were stage I. Most ECs with PGRs also showed TILs and stromal lymphoid reactions, similarly to MMR protein-deficient ECs in general. MMR protein-deficient ECs, particularly those with PMS2 loss, occasionally show PGRs in addition to stromal lymphoid infiltrates and TILs. Therefore, PGRs could be considered to constitute a histological prompt for consideration of Lynch syndrome. The potential prognostic significance of PGRs in EC requires further study. © 2018 John Wiley & Sons Ltd.

9 CFR 2.6 - Annual license fees.

Science.gov (United States)

2010-01-01

... method used to calculate the license fee. All initial license and changed class of license fees must be... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or through an auction sale, by the dealer or applicant during his or her preceding business year (calendar or...

May compact storage facilities be licensed

International Nuclear Information System (INIS)

Gleim, A.; Winter, G.

1980-01-01

The authors examine as potential statements fo fact for licensing so-called compact storage facilities for spent fuel elements Sec. 6 to 9c of the German Atomic Energy Act and Sec. 4 of the German Radiation Protection Ordinance. They find that none of these provisions were applicable to compact stroage facilities. In particular, the storage of spent fuel elements was no storage of nuclear fuels licensable under Sec. 6 of the Atomic Energy Act, because Sec. 6 did not cover spent fuel elements. Also in the other wording of the Atomic Energy Act there was no provision, which could be used as a statement of fact for licensing compact storage facilities. Such facilities could not be licensed and, for that reason, were not permitted. (IVR) [de

76 FR 17840 - Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively

Science.gov (United States)

2011-03-31

... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively AGENCY: Department of the Army, DoD. ACTION: Notice. SUMMARY: The... McGill telephone: 410-436-8467, [email protected]us.army.mil , U.S. Army Edgewood Chemical Biological Center...

RM - ODP to express nuclear licensing

International Nuclear Information System (INIS)

Barbosa, E.A.; Martucci, M. Jr.

2002-01-01

The scope of CNEN (Comissao Nacional de Energia Nuclear) is established by standards and procedures, which allow one context where several activities for nuclear licensing are realized by persons, machines and other entities of real world and by software systems. The CNEN objectives for licensing nuclear installations can be specified and they define how the systems are consisted, its nature, and which important elements were considered relevant for its constitution. The behavior, where the software will be operated, was likely defined in this paper through all aspects of its business process, which means from its licensing context. The concepts and definition showed here defined one specifics business domain, through ODP context. The functionalities of nuclear licensing process, the relationship scope and the rules of interaction that contributed for to specify the nuclear licensing process were defined, too. Therefore, the definition of the domain follows the orientation of architecture concepts and allows to implement the reflection model, where, with the auxiliary from IDEF0 (Integration Definition for Function Modeling) diagrams, the interactions between extern domains were mapped

License - Gclust Server | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Gclust Server License License to Use This Database Last updated : 2009/09/14 You may use this database...scribed below. The Standard License specifies the license terms regarding the use of this database and the r...equirements you must follow in using this database. The Additional License specif...icense. Standard License The Standard License for this database is the license specified in the Creative Com...mons Attribution-Share Alike 2.1 Japan . If you use data from this database, plea

International assistance. Licensing assistance project

International Nuclear Information System (INIS)

Aleev, A.

1999-01-01

Description of licensing assistance project for VATESI is presented. In licensing of unit No.1 of INPP VATESI is supported by many western countries. Experts from regulatory bodies or scientific organizations of those countries assist VATESI staff in reviewing documentation presented by INPP. Among bilateral cooperation support is provided by European Commission through Phare programme

NRC licensing requirements: DOD options

International Nuclear Information System (INIS)

Pike, W.J.; O'Reilly, P.D.

1982-09-01

This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90 Sr or 238 Pu; radioisotopic dynamic electric generators with 90 Sr or 238 Pu; and applications of radioisotopes for luminous sources (lights) with 3 H, 85 Kr, or 147 Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

Overview of the Yucca Mountain Licensing Process

International Nuclear Information System (INIS)

M. Wisenburg

2004-01-01

This paper presents an overview of the licensing process for a Yucca Mountain repository for high-level radioactive waste and spent nuclear fuel. The paper discusses the steps in the licensing proceeding, the roles of the participants, the licensing and hearing requirements contained in the Code of Federal Regulations. A description of the Nuclear Regulatory Commission (NRC) staff acceptance and compliance reviews of the Department of Energy (DOE) application for a construction authorization and a license to receive and possess high-level radioactive waste and spent nuclear fuel is provided. The paper also includes a detailed description of the hearing process

IRIS pre-application licensing

International Nuclear Information System (INIS)

Carelli, Mario D.; Kling, Charles L.; Ritterbusch, Stanley E.

2003-01-01

This paper presents the approach to pre-application licensing by the International Reactor Innovative and Secure (IRIS), and advanced, integral reactor design with a thermal power of 1000 MW. The rationale for the pre-application licensing is discussed. Since IRIS technology is based on proven LWR experience, the project will rely on AP600/AP1000 precedent and will focus during the pre-application on long lead and novel items. A discussion of the evolution of the project to significantly reduce licensing issues is provided, followed by a summary of the IRIS safety-by-design which provides a formidable first step in the Defense in Depth approach. The effects of the safety-by-design, as well as of passive systems, on the IRIS safety will be investigated in a proposed testing program that will be reviewed by NRC during the pre-application. Documentation to be provided to NRC is discussed. Early design analyses indicate that the benefits of the IRIS safety-by-design approach are so significant that the basic premise of current emergency planning regulations (i.e., likelihood of core damage) will be reduced to the extent that special emergency response planning beyond the exclusion area boundary may not be needed. How this very significant outcome can be effected through a highly risk-informed licensing is discussed. (author)

Teacher License Reciprocity. 50-State Review

Science.gov (United States)

Aragon, Stephanie

2017-01-01

This policy report defines and provides a 50-state review of teacher license reciprocity, explores how state-specific licensing requirements impact the teacher labor market, and includes examples of national and state efforts to facilitate reciprocity.

Analysis of CO{sub 2} draining in the supercritical subchannel of an MMR reactor using CFD techniques; Análise do escoamento de CO{sub 2} supercrítico no subcanal de um reator MMR usando técnicas de CFD

Energy Technology Data Exchange (ETDEWEB)

Dutra, Carolina S.B.; Ribeiro, Felipe P., E-mail: cdutra@poli.ufrj.br, E-mail: felipeportor@poli.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Departamento de Engenharia Nuclear; Su, Jian, E-mail: sujian@nuclear.ufrj.br [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

2017-07-01

This work aims to analyze the steady state thermal hydraulic behavior of the supercritical CO{sub 2} by means of the computational modeling of the triangular arrangement subchannel of the KAIST MMR (Korea Advanced Institute of Science and Technology). The mathematical model is composed of Navier-Stokes equations of Reynolds average (RANS), with the model of turbulence k-omega SST (Shear Stress Transport) for the fluid refrigerant in the subchannel and the heat conduction equation for the fuel and coating. The thermodynamic properties of CO{sub 2} are implemented from National Institute of Standards and Technology (NIST) data. The transport equations were solved using a commercial CFD (Fluid Dynamics) tool, ANSYS FLUENT. Initially, a geometric model was constructed, using the ICEM software, composed of fuel, interstice, coating, refrigerant and two adiabatic regions of the fuel rod. The numerical solution used was validated by simulation of a simpler vertical circular tube and by comparisons with numerical and experimental results available in the literature. Using these results, we performed the mesh convergence study and initialized the simulations in the subchannel.

NPP License Renewal and Aging Management: Revised Guidance

International Nuclear Information System (INIS)

Hull, A.B.; Hiser, A.L.; Lindo-Talin, S.E.

2012-01-01

Based on the Atomic Energy Act, the NRC issues licenses for commercial power reactors to operate for up to 40 years and allows these licenses to be renewed for up to another 20 years. NRC has approved license renewal (LR) for well over 50% of U.S. located reactors originally licensed to operate for 40 years. Of these 104 reactors (69 PWRs, 35 BWRs), the NRC has issued renewed licenses for 71 units and is currently reviewing applications for another 15 units. As of May 1, 2012, ten plants at nine sites had entered their 41st year of operation and thus are in their first period of extended operation (PEO). Five more plants will enter the PEO by the end of 2012. One foundation of the license renewal process has been license renewal guidance documents (LRGDs). The U.S. Nuclear Regulatory Commission (NRC) revised key guidance documents used for nuclear power LR in 2010 and 2011. These include NUREG-1800, 'Standard Review Plan for Review of License Renewal Applications,' revision 2 (SRP-LR), and NUREG-1801, 'Generic Aging Lessons Learned (GALL) Report,' revision 2 (GALL Report). The guidance documents were updated to reflect lessons learned and operating experience gained since the guidance documents were last issued in 2005. The reactor LRGDs referenced in this poster can all be accessed at http://www.nrc.gov/reactors/operating/licensing/renewal/guidance.html (author)

Four Essays on Technology Licensing and Firm Innovation

DEFF Research Database (Denmark)

Moreira, Solon

&D strategies. On the supply side, the existing literature has been focused on understanding how technology licensing can be used by firms as a mechanism to recover investments in innovative activities and to foster learning opportunities. On the demand side, it has been shown that licensing is an important...... source that firms can tap into to feed their internal needs for innovative knowledge. While several studies have examined technology licensing through the lens of the licensor, research on how firms rely on licensing contracts to acquire knowledge and improve their innovation performance still leaves......Licensing contracts represent one of the most widely used mechanisms to exchange technologies and transfer know-how between firms. Due to the opportunities that licensing creates for firms operating on both sides of the markets for technology, it has increasingly become an integral part of firms’ R...

A review of tritium licensing requirements

International Nuclear Information System (INIS)

Meikle, A.B.

1982-12-01

Present Canadian regulations and anticipated changes to these regulations relevant to the utilization of tritium in fusion facilities and in commercial applications have been reviewed. It is concluded that there are no serious licensing obstacles, but there are a number of requirements which must be met. A license will be required from Atomic Energy Control Board if Ontario Hydro tritium is to be applied by other users. A license is required from the Federal Government to export or import tritium. A licensed container will be required for the storage and shipping of tritium. The containers being designed by AECL and Ontario Hydro and which are currently being tested will adequately store and ship all of the Ontario Hydro tritium but are unnecessarily large for the small quantities required by the commercial tritium users. Also, some users may prefer to receive tritium in gaseous form. An additional, smaller container should be considered. The licensing of overseas fusion facilities for the use of tritium is seen as a major undertaking offering opportunities to Canadian Fusion Fuels Technology Project to undertake health, safety and environmental analysis on behalf of these facilities

Software licenses: Stay honest!

CERN Multimedia

Computer Security Team

2012-01-01

Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

Effectiveness of Oregon's teen licensing program : final report.

Science.gov (United States)

2008-06-01

Significant changes in Oregons teen licensing laws went into effect on March 1, 2000. The new laws expanded the provisional driving license program which had been in effect since October 1989 and established a graduated driver licensing (GDL) prog...

Assessment of the licensing aspects of HTGR in Yugoslavia

International Nuclear Information System (INIS)

Varazdinec, Z.

1990-01-01

This paper deals not only with the licensing procedure in Yugoslavia, but also reflects the Utility/Owner approach to the assessment of the licensability of the HTGR during the site selection process and especially during bid evaluation process. Besides the description of the existing procedure which was implemented on licensing of LWR program, the assessment of some licensing aspects of HTGR has been presented to describe possible implementation on licensing procedure. (author)

Assessment of the licensing aspects of HTGR in Yugoslavia

Energy Technology Data Exchange (ETDEWEB)

Varazdinec, Z [Institut za Elektroprivredu-Zagreb, Zagreb (Yugoslavia)

1990-07-01

This paper deals not only with the licensing procedure in Yugoslavia, but also reflects the Utility/Owner approach to the assessment of the licensability of the HTGR during the site selection process and especially during bid evaluation process. Besides the description of the existing procedure which was implemented on licensing of LWR program, the assessment of some licensing aspects of HTGR has been presented to describe possible implementation on licensing procedure. (author)

10 CFR 34.13 - Specific license for industrial radiography.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Specific license for industrial radiography. 34.13 Section 34.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY... industrial radiography. An application for a specific license for the use of licensed material in industrial...

Military Infectious Diseases Update on Vaccine Development

Science.gov (United States)

2011-01-24

Licensed live vaccines (polio, MMR) - Radiation- attenuated sporozoites - Genetically- attenuated sporozoites 2011 MHS Conference Whole Organism...Not sufficiently attenuated Seattle Biomedical , Gates Foundation, WEHI and USMMVP 2011 MHS Conference Subunit approach- RTS,S Vaccine RTS,S is...Ad Boost  DNA plasmids [Prime] – Encoding malaria proteins CSP and AMA1  Adenovirus 5 ( attenuated )[Boost] – Encoding malaria proteins CSP and AMA1

An ontology based trust verification of software license agreement

Science.gov (United States)

Lu, Wenhuan; Li, Xiaoqing; Gan, Zengqin; Wei, Jianguo

2017-08-01

When we install software or download software, there will show up so big mass document to state the rights and obligations, for which lots of person are not patient to read it or understand it. That would may make users feel distrust for the software. In this paper, we propose an ontology based verification for Software License Agreement. First of all, this work proposed an ontology model for domain of Software License Agreement. The domain ontology is constructed by proposed methodology according to copyright laws and 30 software license agreements. The License Ontology can act as a part of generalized copyright law knowledge model, and also can work as visualization of software licenses. Based on this proposed ontology, a software license oriented text summarization approach is proposed which performances showing that it can improve the accuracy of software licenses summarizing. Based on the summarization, the underline purpose of the software license can be explicitly explored for trust verification.

Safety philosophy and licensing practice in different member states of IAEA: Canada

International Nuclear Information System (INIS)

Boyd, F.C.

1981-01-01

The lecture will provide an outline of the Canadian nuclear organization and basic characteristics of the CANDU reactor as a background for a brief description of the nuclear power plant licensing process and the safety philosophy followed. The regulatory agency (Atomic Energy Control Board) follows a three step licensing procedure, Site Acceptance, Construction Approval, Operating Licence. Defense in depth is followed as a general safety concept, but is applied in a special way. Completely separate and independant safety systems are required and basic criteria established through reference dose limits for any assumed failure (or initiating event) in any process (operating) system and for any such failure combined with complete failure at any safety system. The application of the Canadian approach in other countries will be mentioned. (orig./RW)

48 CFR 252.227-7007 - License term-running royalty.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License term-running... of Provisions And Clauses 252.227-7007 License term—running royalty. As prescribed at 227.7009-4(b), insert the following clause in patent releases, license agreements, and assignments: License Term—Running...

21 CFR 515.10 - Medicated feed mill license applications.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Medicated feed mill license applications. 515.10... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Applications § 515.10 Medicated feed mill license applications. (a) Medicated feed mill license applications (Forms FDA 3448) may...

License - AcEST | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us AcEST License to Use This Database Last updated : 2010/02/15 You may use this database in co...he Standard License specifies the license terms regarding the use of this database and the requirements you ...must follow in using this database. The Additional License specifies those items ... License The Standard License for this database is the license specified in the Creative Commons Attribution...-Share Alike 2.1 Japan . If you use data from this database, please be sure attribute this database

A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate

DEFF Research Database (Denmark)

Wone, B W M; Madsen, Per; Donovan, E R

2015-01-01

Metabolic rates are correlated with many aspects of ecology, but how selection on different aspects of metabolic rates affects their mutual evolution is poorly understood. Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection...... on mass-independent basal metabolic rate (BMR). Then we tested for responses to selection in MMR and correlated responses to selection in BMR. In other lines, we antagonistically selected for mice with a combination of high mass-independent MMR and low mass-independent BMR. All selection protocols...... and data analyses included body mass as a covariate, so effects of selection on the metabolic rates are mass adjusted (that is, independent of effects of body mass). The selection lasted eight generations. Compared with controls, MMR was significantly higher (11.2%) in lines selected for increased MMR...

77 FR 29701 - Impact of Construction (Under a Combined License) of New Nuclear Power Plant Units on Operating...

Science.gov (United States)

2012-05-18

... New Nuclear Power Plant Units on Operating Units at Multi-Unit Sites AGENCY: Nuclear Regulatory... construct and operate new nuclear power plants (NPPs) on multi-unit sites to provide an evaluation of the... License) of New Nuclear Power Plants on Operating Units at Multi-Unit Sites (Package). ML112630039 Federal...

Impact of 2D/3D-project on LOCA-licensing analysis and reactor safety of PWRs

International Nuclear Information System (INIS)

Winkler, F.; Krebs, W.D.

1989-01-01

In the past LOCA-licensing analysis has included large conservatisms to compensate for the lack of detailed two phase flow and full scale experimental data. The 2D/3D-project was established to improve the data base in order to minimize the conservatisms required. The significant results and findings of the full scale Upper Plenum Test Facility (UPTF) and from the electrically heated Slab Core Test Facility (SCTF) were particularly useful for understanding the multidimensional phenomena in the primary system and in the core of a PWR. UPTF results were used to verify the TRAC-PF1 analysis of a PWR with combined ECC-Injection during the reflood phase of a large break-LOCA. Comparison of these results with results from classic licensing calculations quantifies the large safety margin in earlier licensing procedures and in reactor systems. (orig.)

77 FR 58590 - Determining Technical Adequacy of Probabilistic Risk Assessment for Risk-Informed License...

Science.gov (United States)

2012-09-21

... reactors or for activities associated with review of applications for early site permits and combined licenses (COL) for the Office of New Reactors (NRO). DATES: The effective date of this SRP update is... Rulemaking Web Site: Go to http://www.regulations.gov and search for Docket ID NRC-2010-0138. Address...

10 CFR 71.5 - Transportation of licensed material.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Transportation of licensed material. 71.5 Section 71.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL General Provisions § 71.5 Transportation of licensed material. (a) Each licensee who transports licensed...

Introduction to Technology Export License of Nuclear Facility

Energy Technology Data Exchange (ETDEWEB)

Seo, Hana; Lee, Chansuh; Shin, Donghoon [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

2014-05-15

In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry.

Introduction to Technology Export License of Nuclear Facility

International Nuclear Information System (INIS)

Seo, Hana; Lee, Chansuh; Shin, Donghoon

2014-01-01

In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry

Benchmark for license plate character segmentation

Science.gov (United States)

Gonçalves, Gabriel Resende; da Silva, Sirlene Pio Gomes; Menotti, David; Shwartz, William Robson

2016-09-01

Automatic license plate recognition (ALPR) has been the focus of many researches in the past years. In general, ALPR is divided into the following problems: detection of on-track vehicles, license plate detection, segmentation of license plate characters, and optical character recognition (OCR). Even though commercial solutions are available for controlled acquisition conditions, e.g., the entrance of a parking lot, ALPR is still an open problem when dealing with data acquired from uncontrolled environments, such as roads and highways when relying only on imaging sensors. Due to the multiple orientations and scales of the license plates captured by the camera, a very challenging task of the ALPR is the license plate character segmentation (LPCS) step, because its effectiveness is required to be (near) optimal to achieve a high recognition rate by the OCR. To tackle the LPCS problem, this work proposes a benchmark composed of a dataset designed to focus specifically on the character segmentation step of the ALPR within an evaluation protocol. Furthermore, we propose the Jaccard-centroid coefficient, an evaluation measure more suitable than the Jaccard coefficient regarding the location of the bounding box within the ground-truth annotation. The dataset is composed of 2000 Brazilian license plates consisting of 14000 alphanumeric symbols and their corresponding bounding box annotations. We also present a straightforward approach to perform LPCS efficiently. Finally, we provide an experimental evaluation for the dataset based on five LPCS approaches and demonstrate the importance of character segmentation for achieving an accurate OCR.

The United States nuclear regulatory commission license renewal process

International Nuclear Information System (INIS)

Holian, B.E.

2009-01-01

The United States (U.S.) Nuclear Regulatory Commission (NRC) license renewal process establishes the technical and administrative requirements for the renewal of operating power plant licenses. Reactor ope-rating licenses were originally issued for 40 years and are allowed to be renewed. The review process for license renewal applications (L.R.A.) provides continued assurance that the level of safety provided by an applicant's current licensing basis is maintained for the period of extended operation. The license renewal review focuses on passive, long-lived structures and components of the plant that are subject to the effects of aging. The applicant must demonstrate that programs are in place to manage those aging effects. The review also verifies that analyses based on the current operating term have been evaluated and shown to be valid for the period of extended operation. The NRC has renewed the licenses for 52 reactors at 30 plant sites. Each applicant requested, and was granted, an extension of 20 years. Applications to renew the licenses of 20 additional reactors at 13 plant sites are under review. As license renewal is voluntary, the decision to seek license renewal and the timing of the application is made by the licensee. However, the NRC expects that, over time, essentially all U.S. operating reactors will request license renewal. In 2009, the U.S. has 4 plants that enter their 41. year of ope-ration. The U.S. Nuclear Industry has expressed interest in 'life beyond 60', that is, requesting approval of a second renewal period. U.S. regulations allow for subsequent license renewals. The NRC is working with the U.S. Department of Energy (DOE) on research related to light water reactor sustainability. (author)

Licensing safety critical software

International Nuclear Information System (INIS)

Archinoff, G.H.; Brown, R.A.

1990-01-01

Licensing difficulties with the shutdown system software at the Darlington Nuclear Generating Station contributed to delays in starting up the station. Even though the station has now been given approval by the Atomic Energy Control Board (AECB) to operate, the software issue has not disappeared - Ontario Hydro has been instructed by the AECB to redesign the software. This article attempts to explain why software based shutdown systems were chosen for Darlington, why there was so much difficulty licensing them, and what the implications are for other safety related software based applications

DOE Patents Available for Licensing

International Nuclear Information System (INIS)

Stuber, C.

1981-01-01

DOE Patents Available for Licensing (DOE PAL) provides abstracting and indexing coverage of the DOE patent literature, including patent applications, that concerns any apsect of energy production, conservation, and utilization. The citations are arranged by subject category. DOE is prepared to grant exclusive or nonexclusive, revocable licenses under DOE-owned US patents and patent applications in accordance with the provisions of 10CFR781

77 FR 59193 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2012-09-26

... Type: New OFF License. Bring Logistics US, Inc. (NVO & OFF), 4500 N. Sam Houston Parkway W., 130...: New NVO & OFF License. Contract Logistics, LLC (NVO & OFF), 4911 N. Portland Avenue, Suite 200.... Roush, Manager, Application Type: New NVO & OFF License. Crescent Line Inc. dba Globe Express Services...

25 CFR 558.4 - Granting a gaming license.

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Granting a gaming license. 558.4 Section 558.4 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GAMING LICENSES AND BACKGROUND INVESTIGATIONS FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS GAMING LICENSES FOR KEY EMPLOYEES AND PRIMARY...

75 FR 72824 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2010-11-26

... & OFF License. Everglory Logistics, Inc. (NVO & OFF), 440 McClellan Highway, 105F2, East Boston, MA..., Application Type: New NVO & OFF License. Hawaii Intermodal Tank Transport, LLC (NVO & OFF), 2350 S. Dock... Tran, Manager, Application Type: New NVO & OFF License. ITL USA Inc. dba International Transport...

78 FR 20107 - Ocean Transportation Intermediary License Revocations

Science.gov (United States)

2013-04-03

... to maintain a valid bond. License No.: 016816F. Name: Green Integrated Logistics, Inc. Address: 16210... bond. License No.: 017054NF. Name: Asian Logistics, Inc. Address: 2079 South Atlantic Blvd., Suite D.... License No.: 020715N. Name: HI Trading International Corp. dba HI Transport International dba Shine...

32 CFR 643.126 - Transportation licenses.

Science.gov (United States)

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Transportation licenses. 643.126 Section 643.126... ESTATE Additional Authority of Commanders § 643.126 Transportation licenses. Installation commanders are... free competitive proposals of all available companies or individuals. (b) DD Form 694 (Transportation...

A comparison of licensed and un-licensed artisanal and small-scale gold miners (ASGM) in terms of socio-demographics, work profiles, and injury rates.

Science.gov (United States)

Calys-Tagoe, Benedict N L; Clarke, Edith; Robins, Thomas; Basu, Niladri

2017-11-06

Artisanal and small-scale gold mining (ASGM) represents one of the most hazardous work environments. While formalization of this sector has been suggested (e.g., Minamata Convention) as a means to improve working conditions, we are unaware of empirical evidence that supports this notion. This study aimed to compare sociodemographic profiles, work profiles, and injury rates among miners working in licensed versus un-licensed ASGM sites. In the Tarkwa mining region of Ghana, 404 small-scale miners were recruited in 2014 and interviewed regarding their occupational injury experiences over the preceding 10 years. Workers were drawn from 9 mining sites, of which 5 were licensed and 4 were not licensed. Sociodemographic characteristics of miners from the two groups were relatively similar. Those currently working in an un-licensed mine have spent more time in the ASGM sector than those currently working in a licensed mine (94 vs. 70 months). Miners working in an un-licensed site tended to experience more injury episodes (e.g., 26% vs. 8% had 3 or more injury events) and not use personal protective equipment during the time of an injury (92% indicated to not using vs. 73%) when compared to miners working in a licensed site. A total of 121 injury episodes were recorded for 2245 person years of ASGM work. The injury rate for those working in un-licensed mines was 5.9 per 100 person years (59 injuries in 995 person years) versus 5.0 (62 injuries in 1250 person-years) in the licensed mines. When focusing on the male miners, there was a significant difference in injury rates between those working in a licensed mine (4.2 per 100 person years) versus an un-licensed mine (6.1 per 100 person years). These findings advance our understanding of injuries amongst ASGM workers, and help identify important differences in socio-demographics, work profiles, and injury rates between miners working in a licensed versus and un-licensed site. The findings suggest that certain working

Methodology to identify, review, and evaluate components for license renewal

International Nuclear Information System (INIS)

Carlson, D.D.; Gregor, F.E.; Walker, R.S.

1988-01-01

A methodology has been developed to systematically identify, review, and evaluate plant equipment for license renewal. The method builds upon the existing licensing basis, operating history, and accepted deterministic and probabilistic techniques. Use of these approaches provides a focus for license renewal upon those safety-significant systems and components that are not routinely replaced, refurbished, or subject to detailed inspection as part of the plant's existing test, maintenance, and surveillance programs. Application of the method identified the PWR and BWR systems that should be subjected to detailed license renewal review. Detailed examination of two example systems demonstrates the approach. The review and evaluation of plant equipment for license renewal differ from the initial licensing of the plant. A substantial operating history has been established, the licensing basis has evolved from the original one, and plant equipment has been subject to periodic maintenance and surveillance throughout its life. In consideration of these differences, a basis for license renewal is needed. License renewal should be based upon continuation of the existing licensing basis and recognition of existing programs and operating history

Nuclear relevant installations licensing methodology in the Argentine Republic

International Nuclear Information System (INIS)

Paganini, C.E.

1986-01-01

A review of the requeriments of the Nuclear Installations Advisory Committee on Licensing (CALIN) from the nuclear security point of view, is presented. The methodology applied by the CALIN for the licensing in the Argentine Republic is included as well as codes, standards of applications and the interaction between the licensing Authority and the Responsible Entity during the whole process. Finally, the Atucha II nuclear power plant's licensing, in construction at present, is explained and the standard, of the licensing schedule, is presented graphically. (author) [es

Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro) and a varicella vaccine (VARIVAX) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial.

Science.gov (United States)

Gillet, Yves; Habermehl, Pirmin; Thomas, Stéphane; Eymin, Cécile; Fiquet, Anne

2009-04-14

When this trial was initiated, the combined measles, mumps and rubella (MMR) vaccine was licensed for subcutaneous administration in all European countries and for intramuscular administration in some countries, whereas varicella vaccine was licensed only for subcutaneous administration. This study evaluated the intramuscular administration of an MMR vaccine (M-M-RvaxPro) and a varicella vaccine (VARIVAX) compared with the subcutaneous route. An open-label randomised trial was performed in France and Germany. Healthy children, aged 12 to 18 months, received single injections of M-M-RvaxPro and VARIVAX concomitantly at separate injection sites. Both vaccines were administered either intramuscularly (IM group, n = 374) or subcutaneously (SC group, n = 378). Immunogenicity was assessed before vaccination and 42 days after vaccination. Injection-site erythema, swelling and pain were recorded from days 0 to 4 after vaccination. Body temperature was monitored daily between 0 and 42 days after vaccination. Other adverse events were recorded up to 42 days after vaccination and serious adverse events until the second study visit. Antibody response rates at day 42 in the per-protocol set of children initially seronegative to measles, mumps, rubella or varicella were similar between the IM and SC groups for all four antigens. Response rates were 94 to 96% for measles, 98% for both mumps and rubella and 86 to 88% for varicella. For children initially seronegative to varicella, 99% achieved the seroconversion threshold (antibody concentrations of >or= 1.25 gpELISA units/ml). Erythema and swelling were the most frequently reported injection-site reactions for both vaccines. Most injection-site reactions were of mild intensity or small size (vaccines was comparable regardless of administration route. Integration of both administration routes in the current European indications for the two vaccines will now allow physicians in Europe to choose their preferred administration route

48 CFR 1352.239-70 - Software license addendum.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Software license addendum... Software license addendum. As prescribed in 48 CFR 1339.107, insert the following clause: Software License....S.C. Section 516). (h) Renewal of Support after Expiration of this Award: Service will not...

76 FR 70145 - Ocean Transportation Intermediary License; Applicants

Science.gov (United States)

2011-11-10

...). Application Type: New NVO License. Alomar Transport, Inc. (NVO & OFF), 150-30 132nd Avenue, Suite 303, Jamaica... & OFF License. Forward System Logistics Inc. (NVO), 144-54 156th Street, Jamaica, NY 11434. Officers... NVO License. Green Line Shipping & Logistics Services Inc. (NVO & OFF), 16230 Lake View Lane, Apple...

76 FR 3635 - Ocean Transportation Intermediary License Revocation

Science.gov (United States)

2011-01-20

... to maintain a valid bond. License Number: 004094F. Name: All Transport, Inc. Address: 8369 NW. 66th.... License Number: 020410F. Name: MBA Logistics, LLC. Address: 11455 Narin Drive, Brighton, MI 48114. Date... valid bonds. License Number: 021204NF. Name: United Logistics Corp. Address: 3650 Mansell Road, Suite...

76 FR 22106 - Ocean Transportation Intermediary License Revocation

Science.gov (United States)

2011-04-20

...: Failed to maintain a valid bond. License Number: 018088N. Name: ILS-International Logistics Solutions... maintain a valid bond. License Number: 019369N. Name: Independent Transport Line, LLC dba ITL. Address... bond. License Number: 022322N. Name: O.T.S. Logistics, Inc. Address: 18726 South Western Avenue, Suite...

Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors

DEFF Research Database (Denmark)

Ketabi, Zohreh; Bartuma, Katarina; Bernstein, Inge

2011-01-01

. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. CONCLUSION: The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch...

License - Open TG-GATEs | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Open TG-GATEs License License to Use This Database Last updated : 2012/05/24 You may use this database...scribed below. The Standard License specifies the license terms regarding the use of this database and the r...equirements you must follow in using this database. The Additional License specif...icense. Standard License The Standard License for this database is the license specified in the Creative Com...mons Attribution-Share Alike 2.1 Japan . If you use data from this database, plea

U.S. regulatory requirements for nuclear plant license renewal: The B and W Owners Group License Renewal Program

International Nuclear Information System (INIS)

Staudinger, Deborah K.

2004-01-01

This paper discusses the current U.S. Regulatory Requirements for License Renewal and describes the Babcock and Wilcox Owners Group (B and WOG) Generic License Renewal Program (GLRP). The B and W owners, recognizing the need to obtain the maximum life for their nuclear generating units, embarked on a program to renew the licenses of the seven reactors in accordance with the requirements of the Atomic Energy Act of 1954 and further defined by Title 10 of the Code of Federal Regulation Part 54 (10 CFR 54). These reactors, owned by five separate utilities, are Pressurized Water Reactors (PWR) ranging in net rated capacity from approximately 800 to 900 MW. The plants, predominately constructed in the 70s, have USNRC Operating Licenses that expire between 2013 to 2017. (author)

Optimal Licensing Strategy: Royalty or Fixed Fee?

OpenAIRE

Andrea Fosfuri; Esther Roca

2004-01-01

Licensing a cost-reducing innovation through a royalty has been shown to be superior to licensing by means of a fixed fee for an incumbent licensor. This note shows that this result relies crucially on the assumption that the incumbent licensor can sell its cost-reducing inno-vation to all industry players. If, for any reason, only some competitors could be reached through a licensing contract, then a fixed fee might be optimally chosen.

Postulated licensing schedule for an independent spent-fuel-storage installation

International Nuclear Information System (INIS)

Ludwick, J.D.

1982-11-01

A review of licensing requirements, processes, and anticipated actions for independent spent fuel storage installations (ISFSIs) was conducted in order to develop an estimated schedule and sequence of events for licensing a new ISFSI. This estimate will be useful to potential ISFSI owners in planning for the licensing of their facilities. It is concluded that, although many uncertainties exist with respect to such things as legal appeals, about 29 months are estimated to elapse between license application and license issuance for an ISFSI. This estimate is in reasonable agreement with a previous time estimate for licensing an ISFSI, and, taking into account the special circumstances involved, with the actual licensing schedule for the GE-Morris ISFSI. However, individual portions of the licensing schedule from each case studied sometimes vary significantly

Technology Licensing Strategy for Network Product in a Service Industry

Directory of Open Access Journals (Sweden)

Xianpei Hong

2015-01-01

Full Text Available Technology licensing has gained significant attention in literature and practice as a rapid and effective way to improve firm’s capability of technology innovation. In this paper, we investigate a duopolistic service provider competition market, where service providers develop and sell a kind of network product. In this setting, we analyze the innovating service provider’s four licensing strategies: no licensing, fixed fee licensing, royalty licensing, and two-part tariff licensing. The literature suggests that when the network products can be completely substituted, two-part tariff licensing is the optimal strategy of the innovating service provider. We find that when the network products cannot be completely substituted, two-part tariff licensing is not always optimal. The degree of the product differentiation, the intensity of the network effects, and the R&D cost of the potential licensee play a key role in determining the innovating service provider’s optimal licensing strategies.

License - TMFunction | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us TMFunction License License to Use This Database Last updated : 2017/01/23 You may use this database...e license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attributio...n-Share Alike 4.0 International . If you use data from this database, please be sure attribute this database...ion-Share Alike 4.0 International is found here . With regard to this database, you are licensed to: freely

The case against a smoker's license.

Directory of Open Access Journals (Sweden)

Jeff Collin

Full Text Available Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers designed to limit access to tobacco products and encourage cessation. Key elements of the smoker's license include smokers setting daily limits, financial incentives for permanent license surrender, and a test of health risk knowledge for commencing smokers. Collin argues against the proposal, saying that it would shift focus away from the real vector of the epidemic--the tobacco industry--and that by focusing on individuals it would censure victims, increase stigmatization of smokers, and marginalize the poor.

The case for a smoker's license.

Directory of Open Access Journals (Sweden)

Simon Chapman

Full Text Available BACKGROUND TO THE DEBATE: Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers designed to limit access to tobacco products and encourage cessation. Key elements of the smoker's license include smokers setting daily limits, financial incentives for permanent license surrender, and a test of health risk knowledge for commencing smokers. Collin argues against the proposal, saying that it would shift focus away from the real vector of the epidemic--the tobacco industry--and that by focusing on individuals it would censure victims, increase stigmatization of smokers, and marginalize the poor.

The case for a smoker's license.

Science.gov (United States)

Chapman, Simon

2012-01-01

Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers designed to limit access to tobacco products and encourage cessation. Key elements of the smoker's license include smokers setting daily limits, financial incentives for permanent license surrender, and a test of health risk knowledge for commencing smokers. Collin argues against the proposal, saying that it would shift focus away from the real vector of the epidemic--the tobacco industry--and that by focusing on individuals it would censure victims, increase stigmatization of smokers, and marginalize the poor.

The case against a smoker's license.

Science.gov (United States)

Collin, Jeff

2012-01-01

Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers designed to limit access to tobacco products and encourage cessation. Key elements of the smoker's license include smokers setting daily limits, financial incentives for permanent license surrender, and a test of health risk knowledge for commencing smokers. Collin argues against the proposal, saying that it would shift focus away from the real vector of the epidemic--the tobacco industry--and that by focusing on individuals it would censure victims, increase stigmatization of smokers, and marginalize the poor.

36 CFR 264.3 - Licensing for commercial use.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Licensing for commercial use... PROPERTY MANAGEMENT Official Forest Service Insignia § 264.3 Licensing for commercial use. (a) Each commercial license granted for the use of the insignia or likeness thereof shall contain the following terms...

Compliance with driver's license laws and illegal licensing among commercial bus drivers in Lagos, Nigeria: policy implications and evidence for action.

Science.gov (United States)

Okafor, I P; Odeyemi, K A; Dolapo, D C; Adegbola, A A

2014-09-01

To determine the level of compliance with driver's license laws among commercial bus drivers in Lagos, Nigeria. Two intercity motor parks were selected by simple random sampling and all consenting minibus drivers participated in the study. Key Informant Interviews (KIIs) were also conducted with selected officials in the driver training and licensing authorities. Compliance with the minimum age for driving was high (93.6%), so also was having driving test prior to driver's license procurement (83.3%). Formal driver training and VA testing were very low, (26.1% and 32.9% respectively) Overall, only 9.3% of them were found to have fulfilled all the pre-license obligations before obtaining their first driver's license. The odds of a driver with a secondary education having formal driver training is 3.33 times higher than those with no education (OR 3.33, 95% CI 1.01-11.35). Drivers who were 60 years or older were 3.62 times more likely to be compliant than those who were between 20-29 years (OR 3.62, 95% CI 0.56-29.19). For the 98.3% of them who possessed valid licenses, 52.3% of them obtained them illegally. All the key officials saw RTIs as a serious public health problem but faced several challenges in the course of their work. Overall compliance with pre-license regulations was very poor. There is need for a review and strict enforcement of driver's license laws to improve compliance. Also vital are fostering inter-sectoral collaboration and improvement in the operations of all establishments involved in driver training and license procurement in Nigeria.

75 FR 4571 - Government-Owned Inventions; Availability for Licensing

Science.gov (United States)

2010-01-28

.... Applications: Therapies for tumors associated with NF1 (including brain and peripheral nervous system tumors...-US-01). Licensing Status: Available for licensing. Licensing Contact: Patrick P. McCue, Ph.D.; 301...

List of Nuclear Materials Licensing Actions Received

Data.gov (United States)

Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

36 CFR 271.4 - Commercial license.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Commercial license. 271.4... BEARâ SYMBOL § 271.4 Commercial license. (a) The Chief may authorize the commercial manufacture... a use or royalty charge which is reasonably related to the commercial enterprise has been...

NEG-shift, Licensing, and Repair Strategies

DEFF Research Database (Denmark)

Christensen, Ken Ramshøj

2008-01-01

I entertain the idea that the cross-linguistic variation in the licensing of NEG-shift, the movement of negative objects to spec-NegP, can be accounted for by a few representational constraints that are not directly related to case licensing or feature checking, and which potentially conflict...

TMI-related requirements for new operating licenses. Technical report

International Nuclear Information System (INIS)

1980-06-01

There are four types of TMI-related requirements and actions approved by the Commission for new operating licenses: (1) those required to be completed by a license applicant prior to receiving a fuel-loading and low-power testing license, (2) those required to be completed by a license applicant prior to receiving a license to operate at appreciable power levels up to full power, (3) those the NRC will take prior to issuing a fuel-loading and low-power testing or a full-power operating license, and (4) those required to be completed by a licensee prior to a specified date. In this report, only those dated requirements that have already been issued are of interest. Other dated requirements are expected to be issued in the future as work progresses in accordance with the TMI Action Plan. This report summarizes the several parts of the list of TMI-related requirements approved by the Commission for new operating licenses

Reassessing Occupational Licensing Of Tour Guides (Opinion Piece

Directory of Open Access Journals (Sweden)

Amir SHANI

2017-06-01

Full Text Available It is conventionally held that to protect tourists from incompetent and/or unscrupulous tour guides, governments should require guides to be licensed in order to legally practice their profession. Despite the implementation of such regulatory statutes in many countries, it is argued in this opinion paper that the severe drawbacks of licensing demands should be re-evaluated by both policy-makers and tourism scholars. The licensing of guides is not only an ineffective means of quality assurance, with negative consequences for many of those involved, but it also undermines the ethical foundations of a free society. Furthermore, licensing is an archaic practice for ensuring standardization among the members of a profession in a way that is no longer suitable for addressing the challenges of the tourism industry in the 21st century, in which a wide variety of specialized and innovative guided tours are offered to tourists. Although this commentary presents a firm stand against the compulsory licensing of tour guides, it should be seen as an invitation for open discussion among tourism researchers regarding the necessity of licensing tour guides in particular, and of government tourism regulation in general. Moreover, further research is needed to clarify key points on the issue of the professional licensing of tour guides.

50 CFR 80.4 - Diversion of license fees.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Diversion of license fees. 80.4 Section 80... fees. Revenues from license fees paid by hunters and fishermen shall not be diverted to purposes other than administration of the State fish and wildlife agency. (a) Revenues from license fees paid by...

27 CFR 555.45 - Original license or permit.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Original license or permit. 555.45 Section 555.45 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS... Original license or permit. (a) Licenses issued prior to May 24, 2003. Any person who intends to engage in...

Summary of NRR future licensing activities

International Nuclear Information System (INIS)

2001-01-01

In response to a renewed interest in building nuclear power plants, the NRC has created organizations within its major program offices to prepare the NRC staff for new applications (early site permits [ESPs], design certifications, and combined licenses) and to manage special task groups and pro-application reviews of new reactor designs. Activities planned in FY2001 and FY2002 include: (1) evaluating the ability of the NRC staff to support future application reviews under 10 CFR Parts 50 and 52; (2) performing pre-application reviews of the API 000 (a light-water reactor design with passive safety systems), Pebble Bed Modular Reactor (PBMR - a high-temperature gas-cooled reactor design), ESPs, IRIS (an advanced light-water reactor design), and GT-MHR (a high-temperature gas-cooled reactor design); (3) initiating and/or performing related rulemakings that will update 10 CPR Part 52 to reflect lessons learned from certifying three nuclear plant designs, update Tables S-3 and S-4 of 10 CFR Part 51 to address higher burnup fuel considerations and non-LWR advanced designs, and address alternative siting considerations; (4) reactivating the construction inspection program; and, (5) interacting with stakeholders to ensure there is a clear understanding of upcoming activities related to future applications and to solicit stakeholder input. In FY2002 and FY200S, activities are expected to include: (1) managing the reviews of fine new applications resulting from the pre-application reviews (including one design certification, one combined license, and three ESP reviews); (2) managing two pre-application reviews (IRIS and QT-MHR); (3) updating regulatory and review guidance for new applications, i.e., Standard Review Plans (SRPs), Regulatory Guides, and referenced codes and standards, and identifying where enhancements are needed; (4) developing independent codes to analyze the safety of non-LWR designs, with supporting validation testing; and, (5) addressing regulatory

Perspective about the US license Renewal for NNPP's

International Nuclear Information System (INIS)

Lehnert, D. F.

2004-01-01

This article provides and overview of the US License Renewal Rule, 10 CFR 54, and its implementation in the US leading to the preparation and review of a license renewal application. The key regulatory documents and the industry's methodology and guidance for successfully implementing the Rule are discussed. While the process still undergoes change and optimization, it has become predictable and reliable, such that utilities can establish realistic schedules and budgets to complete the license renewal process. Nearly 60% of the US operating units have either received and extended operating license, have submitted their application for review, or have committed to submit an application in the next few years. The article concludes with a discussion of lessons learned from this wealth of experience and some emerging issues that may affect license renewal process. (Author)

A comparison of licensed and un-licensed artisanal and small-scale gold miners (ASGM in terms of socio-demographics, work profiles, and injury rates

Directory of Open Access Journals (Sweden)

Benedict N. L. Calys-Tagoe

2017-11-01

Full Text Available Abstract Background Artisanal and small-scale gold mining (ASGM represents one of the most hazardous work environments. While formalization of this sector has been suggested (e.g., Minamata Convention as a means to improve working conditions, we are unaware of empirical evidence that supports this notion. This study aimed to compare sociodemographic profiles, work profiles, and injury rates among miners working in licensed versus un-licensed ASGM sites. Methods In the Tarkwa mining region of Ghana, 404 small-scale miners were recruited in 2014 and interviewed regarding their occupational injury experiences over the preceding 10 years. Workers were drawn from 9 mining sites, of which 5 were licensed and 4 were not licensed. Results Sociodemographic characteristics of miners from the two groups were relatively similar. Those currently working in an un-licensed mine have spent more time in the ASGM sector than those currently working in a licensed mine (94 vs. 70 months. Miners working in an un-licensed site tended to experience more injury episodes (e.g., 26% vs. 8% had 3 or more injury events and not use personal protective equipment during the time of an injury (92% indicated to not using vs. 73% when compared to miners working in a licensed site. A total of 121 injury episodes were recorded for 2245 person years of ASGM work. The injury rate for those working in un-licensed mines was 5.9 per 100 person years (59 injuries in 995 person years versus 5.0 (62 injuries in 1250 person-years in the licensed mines. When focusing on the male miners, there was a significant difference in injury rates between those working in a licensed mine (4.2 per 100 person years versus an un-licensed mine (6.1 per 100 person years. Conclusions These findings advance our understanding of injuries amongst ASGM workers, and help identify important differences in socio-demographics, work profiles, and injury rates between miners working in a licensed versus and un-licensed

Licensing of simple digital devices

International Nuclear Information System (INIS)

Jackson, T. W.

2008-01-01

The inability to guarantee error-free software gave rise to the potential for common-cause failure of digital safety systems in nuclear power plants. To address this vulnerability, the U. S. Nuclear Regulatory Commission (NRC) required a quality software development process and a defense-in-depth and diversity analysis for digital safety systems. As a result of recent interim [NRC] staff guidance in the digital instrumentation and control (I and C) area, licensing of simple digital devices decreases some regulatory burden with respect to demonstrating a quality software development process and defense-in-depth and diversity analysis. This paper defines simple digital devices and addresses the interim staff guidance that applies to such devices. The paper also highlights the technical aspects that affect the licensing of such devices and incorporates licensing experience in the U.S. to date. (authors)

27 CFR 478.44 - Original license.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Original license. 478.44 Section 478.44 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND....44 Original license. (a)(1) Any person who intends to engage in business as a firearms or ammunition...

Licensing of nuclear reactor operators

International Nuclear Information System (INIS)

1979-09-01

Recommendations are presented for the licensing of nuclear reactor operators in units licensed according to the legislation in effect. They apply to all physical persons designated by the Operating Organization of the nuclear reactor or reactors to execute any of the following functional activities: a) to manipulate the controls of a definite reactor b) to direct the authorized activities of the reactor operators licesed according to the present recommendations. (F.E.) [pt

Scallop License Limitation Program (SLLP) Permit Program

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — A federal Scallop License Limitation Program (SLLP) license is required onboard any vessel deployed in scallop fisheries in Federal waters off Alaska (except for...

Mismatch repair proficiency is not required for radioenhancement by gemcitabine

International Nuclear Information System (INIS)

Bree, Chris van; Rodermond, Hans M.; Vos, Judith de; Haveman, Jaap; Franken, Nicolaas

2005-01-01

Purpose: Mismatch repair (MMR) proficiency has been reported to either increase or decrease radioenhancement by 24-h incubations with gemcitabine. This study aimed to establish the importance of MMR for radioenhancement by gemcitabine after short-exposure, high-dose treatment and long-exposure, low-dose treatment. Methods and Materials: Survival of MMR-deficient HCT116 and MMR-proficient HCT116 + 3 cells was analyzed by clonogenic assays. Mild, equitoxic gemcitabine treatments (4 h, 0.1 μM vs. 24 h, 6 nM) were combined with γ-irradiation to determine the radioenhancement with or without recovery. Gemcitabine metabolism and cell-cycle effects were evaluated by high-performance liquid chromatography analysis and bivariate flow cytometry. Results: Radioenhancement after 4 h of 0.1 μM of gemcitabine was similar in both cell lines, but the radioenhancement after 24 h of 6 nM of gemcitabine was reduced in MMR-proficient cells. No significant differences between both cell lines were observed in the gemcitabine metabolism or cell-cycle effects after these treatments. Gemcitabine radioenhancement after recovery was also lower in MMR-proficient cells than in MMR-deficient cells. Conclusion: Mismatch repair proficiency decreases radioenhancement by long incubations of gemcitabine but does not affect radioenhancement by short exposures to a clinically relevant gemcitabine dose. Our data suggest that MMR contributes to the recovery from gemcitabine treatment

Empirical Study of Car License Plates Recognition

OpenAIRE

Dina, Nasa Zata; Dailey, Matthew

2015-01-01

The number of vehicles on the road has increased drastically in recent years. The license plate is an identity card for a vehicle. It can map to the owner and further information about vehicle. License plate information is useful to help traffic management systems. For example, traffic management systems can check for vehicles moving at speeds not permitted by law and can also be installed in parking areas to se-cure the entrance or exit way for vehicles. License plate recognition algorithms ...

Guide to request license for teletherapy practice

International Nuclear Information System (INIS)

2000-01-01

In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

78 FR 70955 - Prospective Grant of Exclusive Patent License: GMCSF-BclxL-Derived Chimeric Therapeutics for Use...

Science.gov (United States)

2013-11-27

... Exclusive Patent License: GMCSF-BclxL- Derived Chimeric Therapeutics for Use in Treatment of Cancer...-BclxL-derived chimeric therapeutics and immunotherapeutics, alone or in combination, for restoring...: [email protected] . SUPPLEMENTARY INFORMATION: The subject invention is to a chimeric protein...

Development of radioactive waste management licensing review assistant

International Nuclear Information System (INIS)

Wei-Whua Loa; Suan Chen; Wei-Chu Yu

1992-01-01

Regulations on radioactive waste disposal are now in urgent need due to our increasing consumption of electric power from nuclear origin. It is set forth that actually applying the regulations to evaluate the license application of new repositories for interim storage and final disposal of High-Level Waste and Low-Level Waste before the year of 2000. In the mean time, it is expected to establish the basis for the decision on issuing the license. The license review procedure can be very complicated, because too many factors must be taken into consideration. For the time being, licensing review is as much an art as it is a science. The authority usually faces three major problems; (1) the availability of domain expert, (2) maintaining of high quality and consistent reviews, and (3) the documentation of the review process. However, to maintain a more efficient, accurate, and systematic review procedure, and at the same time to reduce costs, the Artificial Intelligence (AI) techniques may be used. An expert system is designed as a radioactive waste management licensing review aid for the staff those are in charge of the license application. Tasks such as completeness checking, functional areas of review distribution, participation confirmation, knowledge acquisition, review comment collection, weighting calculation, and degree of satisfaction are considered. In this paper we will discuss the development of the radioactive waste management licensing review assistant

License - DGBY | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available rch Institute, National Agriculture and Food Research Organization (NARO) 2-1-12 Kannondai, Tsukuba, Ibaraki...t a license for use of this database or any part thereof not licensed under the license. National Food Resea

License - Dicty_cDB | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Dicty_cDB License to Use This Database Last updated : 2010/02/15 You may use this database i...w. The Standard License specifies the license terms regarding the use of this database and the requirements ...you must follow in using this database. The Additional License specifies those it...dard License The Standard License for this database is the license specified in the Creative Commons Attribu...tion-Share Alike 2.1 Japan . If you use data from this database, please be sure attribute this database

Progress in licensing ITER in Cadarache

International Nuclear Information System (INIS)

Rodriguez-Rodrigo, Lina; Girard, Jean-Philippe; Uzan-Elbez, Joelle; Marbach, Gabriel; Garin, Pascal; Rosanvallon, Sandrine

2005-01-01

The licensing procedure for ITER in Europe in the framework of the French regulations is a non-prescriptive approach based on a continuous dialogue between the nuclear installation owner (or its representative) and the safety authority. In this paper, the licensing procedure and main safety issues, which are being studied in this process, are presented

Operating reactors licensing actions summary. Volume 5, No. 2

International Nuclear Information System (INIS)

1985-04-01

The Operating Reactors Licensing Actions Summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Resource Management. This summary report is published primarily for internal NRC use in managing the Operating Reactors Licensing Actions Program

Nuclear power plant operator licensing

International Nuclear Information System (INIS)

1997-01-01

The guide applies to the nuclear power plant operator licensing procedure referred to the section 128 of the Finnish Nuclear Energy Degree. The licensing procedure applies to shift supervisors and those operators of the shift teams of nuclear power plant units who manipulate the controls of nuclear power plants systems in the main control room. The qualification requirements presented in the guide also apply to nuclear safety engineers who work in the main control room and provide support to the shift supervisors, operation engineers who are the immediate superiors of shift supervisors, heads of the operational planning units and simulator instructors. The operator licensing procedure for other nuclear facilities are decided case by case. The requirements for the basic education, work experience and the initial, refresher and complementary training of nuclear power plant operating personnel are presented in the YVL guide 1.7. (2 refs.)

Information is in the eye of the beholder: Seeking information on the MMR vaccine through an Internet search engine.

Science.gov (United States)

Yom-Tov, Elad; Fernandez-Luque, Luis

2014-01-01

Vaccination campaigns are one of the most important and successful public health programs ever undertaken. People who want to learn about vaccines in order to make an informed decision on whether to vaccinate are faced with a wealth of information on the Internet, both for and against vaccinations. In this paper we develop an automated way to score Internet search queries and web pages as to the likelihood that a person making these queries or reading those pages would decide to vaccinate. We apply this method to data from a major Internet search engine, while people seek information about the Measles, Mumps and Rubella (MMR) vaccine. We show that our method is accurate, and use it to learn about the information acquisition process of people. Our results show that people who are pro-vaccination as well as people who are anti-vaccination seek similar information, but browsing this information has differing effect on their future browsing. These findings demonstrate the need for health authorities to tailor their information according to the current stance of users.

The nuclear licensing procedure

International Nuclear Information System (INIS)

Wagner, H.

1976-01-01

To begin with, the present nuclear licensing procedure is illustrated by a diagram. The relationship between the state and the Laender, the various experts (GRS - IRS + LRA -, TUEV, DWD, university institutes, firms of consulting engineers, etc), participation of the public, e.g. publication of the relevant documents, questions, objections (made by individuals or by groups such as citizens' initiatives), public discussion, official notice, appeals against the decision, the right of immediate execution of the decision are shortly dealt with. Finally, ways to improve the licensing procedure are discussed, from the evaluation of the documents to be submitted, published, and examined by the authorities (and their experts) up to an improvement of the administrative procedure. An improved licensing procedure should satisfy the well-founded claims of the public for more transparency as well as the equally justifiable claims of industry and utilities in order to ensure that the citizens' legal right to have safe and adequate electric power is guaranteed. The updated energy programme established by the Federal Government is mentioned along with the effectiveness of dealing with nuclear problems on the various levels of a Land government. (orig.) [de

Development of radioactive waste management licensing review assistant

International Nuclear Information System (INIS)

Loa, W.W.; Chen, S.; Yu, W.C.; Peng, C.M.; Huang, C.L.; Lin, C.

1992-01-01

Regulations on radioactive waste disposal are now in urgent need due to our increasing consumption of electric power from nuclear origin. It is set forth that actually applying the regulations to evaluate the license application of new repositories for interim storage and final disposal fo High-Level Waste and Low-Level Waste before the year of 2000. In the mean time, it is expected to establish the basis for the decision on issuing the license. The license review procedure can be very complicated because too many factors must be taken into consideration. However, to maintain a more efficient, accurate, and systematic review procedure, and at the same time to reduce costs, the Artificial Intelligence (AI) techniques may be used. An expert system is designed as a radioactive waste management licensing review aid for the staff those are in charge of the license application. Tasks such as completeness checking, functional areas of review distribution, participation confirmation, knowledge acquisition, review comment collection, weighting calculation, and degree of satisfaction are considered. In this paper the authors will discuss the development of the radioactive waste management licensing review assistant

Licensing Surrogate Decision-Makers.

Science.gov (United States)

Rosoff, Philip M

2017-06-01

As medical technology continues to improve, more people will live longer lives with multiple chronic illnesses with increasing cumulative debilitation, including cognitive dysfunction. Combined with the aging of society in most developed countries, an ever-growing number of patients will require surrogate decision-makers. While advance care planning by patients still capable of expressing their preferences about medical interventions and end-of-life care can improve the quality and accuracy of surrogate decisions, this is often not the case, not infrequently leading to demands for ineffective, inappropriate and prolonged interventions. In 1980 LaFollette called for the licensing of prospective parents, basing his argument on the harm they can do to vulnerable people (children). In this paper, I apply his arguments to surrogate decision-makers for cognitively incapacitated patients, rhetorically suggesting that we require potential surrogates to qualify for this position by demonstrating their ability to make reasonable and rational decisions for others. I employ this theoretical approach to argue that the loose criteria by which we authorize surrogates' generally unchallenged power should be reconsidered.

48 CFR 1852.227-86 - Commercial computer software-Licensing.

Science.gov (United States)

2010-10-01

.../contractor proposes its standard commercial software license, those applicable portions thereof consistent... its standard commercial software license until after this purchase order/contract has been issued, or at or after the time the computer software is delivered, such license shall nevertheless be deemed...

Operating reactors licensing actions summary. Vol. 3, No. 3

International Nuclear Information System (INIS)

1983-04-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regularory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program

Licensed bases management for advanced nuclear plants

International Nuclear Information System (INIS)

O'Connell, J.; Rumble, E.; Rodwell, E.

2001-01-01

Prospective Advanced Nuclear Plant (ANP) owners must have high confidence that the integrity of the licensed bases (LB) of a plant will be effectively maintained over its life cycle. Currently, licensing engineers use text retrieval systems, database managers, and checklists to access, update, and maintain vast and disparate licensing information libraries. This paper describes the demonstration of a ''twin-engine'' approach that integrates a program from the emerging class of concept searching tools with a modern Product Data Management System (PDMS) to enhance the management of LB information for an example ANP design. (author)

Licensed bases management for advanced nuclear plants

Energy Technology Data Exchange (ETDEWEB)

O' Connell, J [Duke Engineering and Services, Marlborough, MA (United States); Rumble, E; Rodwell, E [EPRI, Palo Alto, CA (United States)

2001-07-01

Prospective Advanced Nuclear Plant (ANP) owners must have high confidence that the integrity of the licensed bases (LB) of a plant will be effectively maintained over its life cycle. Currently, licensing engineers use text retrieval systems, database managers, and checklists to access, update, and maintain vast and disparate licensing information libraries. This paper describes the demonstration of a ''twin-engine'' approach that integrates a program from the emerging class of concept searching tools with a modern Product Data Management System (PDMS) to enhance the management of LB information for an example ANP design. (author)

Atomic Safety and Licensing Board Panel annual report

International Nuclear Information System (INIS)

1991-09-01

In Fiscal Year 1990, The Atomic Safety and Licensing Board Panel (Panel) handled 40 proceedings involving the construction, operation, and maintenance of commercial nuclear power reactors or other activities requiring a license from the Nuclear Regulatory Commission. This report summarizes, highlights, and analyzes how the judges and licensing boards of the Panel addressed the wide-ranging issues raised in these proceedings during the year

The road to MYRRHA. The pre-licensing phase and FEED

International Nuclear Information System (INIS)

2014-01-01

The article discusses the study phase of the future research reactor MYRRHA. This study phase covers three major areas: Research and Development, licensing and engineering. In 2013, substantial progress was made in the licensing and engineering processes: licensing is currently in the pre-licensing phase, while, for engineering, the Front-end Engineering and Design (FEED) contract was signed for the construction of the non-nuclear parts of MYRRHA. The article highlights work associated with the the pre-licensing phase and the FEED.

Systems engineering and the licensing of Small Modular Reactors

Energy Technology Data Exchange (ETDEWEB)

Kulesa, T., E-mail: tkulesa@us.ibm.com [IBM, Philidelphia, Pennsylvania (United States); Soderholm, K., E-mail: Kristiina.Soderholm@fortum.com [Fortum Power (Finland); Fechtelkotter, P., E-mail: pfech@us.ibm.com [IBM, Boston, Massacheusets (United States)

2014-07-01

Both global warming and the need for dependable sources of energy continue to make nuclear power generation an appealing option. But a history of cost overruns, project delays, and environmental disaster has pushed the industry to innovate and design a more flexible, scalable, and safe source of nuclear energy - the small modular reactor. Innovation in generation technology creates disruption in already complex licensing and regulatory processes. This paper discusses how the application of systems engineering and requirements management can help combat confusion, rework, and efficiency problems across the engineering and compliance life cycle. The paper is based on the PhD Dissertation 'Licensing Model Development for Small Modular Reactors (SMRs) - Focusing on Finnish Regulatory Framework', approved in 2013. The result of the study gives recommendations and tools to develop and optimize the licensing process for SMRs. The most important SMR-specific feature, in terms of licensing, is the modularity of the design. Here the modularity indicates multi-module SMR designs, which creates new challenges in the licensing process. Another feature impacting licensing feasibility is the plan to build many standardized power plants in series and use factory-fabricated modules to optimize the construction costs. SMR licensing challenges are under discussion in many international forums, such as World Nuclear Association Cooperation in Reactor Design Evaluation and Licensing Small Modular Reactor group (WNA CORDEL SMR) group and IAEA INPRO regulators' forum. This paper also presents an application of the new licensing process using Systems Engineering, Requirements Management, and Project Management practices and tools. (author)

Systems engineering and the licensing of Small Modular Reactors

International Nuclear Information System (INIS)

Kulesa, T.; Soderholm, K.; Fechtelkotter, P.

2014-01-01

Both global warming and the need for dependable sources of energy continue to make nuclear power generation an appealing option. But a history of cost overruns, project delays, and environmental disaster has pushed the industry to innovate and design a more flexible, scalable, and safe source of nuclear energy - the small modular reactor. Innovation in generation technology creates disruption in already complex licensing and regulatory processes. This paper discusses how the application of systems engineering and requirements management can help combat confusion, rework, and efficiency problems across the engineering and compliance life cycle. The paper is based on the PhD Dissertation 'Licensing Model Development for Small Modular Reactors (SMRs) - Focusing on Finnish Regulatory Framework', approved in 2013. The result of the study gives recommendations and tools to develop and optimize the licensing process for SMRs. The most important SMR-specific feature, in terms of licensing, is the modularity of the design. Here the modularity indicates multi-module SMR designs, which creates new challenges in the licensing process. Another feature impacting licensing feasibility is the plan to build many standardized power plants in series and use factory-fabricated modules to optimize the construction costs. SMR licensing challenges are under discussion in many international forums, such as World Nuclear Association Cooperation in Reactor Design Evaluation and Licensing Small Modular Reactor group (WNA CORDEL SMR) group and IAEA INPRO regulators' forum. This paper also presents an application of the new licensing process using Systems Engineering, Requirements Management, and Project Management practices and tools. (author)

A new licensing strategy for Canadian mobile earth stations

Science.gov (United States)

Amero, Ronald G.

1990-01-01

Initiatives presently under consideration by the Department of Communications which will greatly simplify the licensing process for mobile earth stations are addressed. The current licensing approach is reviewed and the limitations of that system identified. A new approach is needed to respond to the needs of mobile satellite users in the 1990's and beyond, one which will have a minimal impact on the user while still respecting the legislative responsibilities of the department under the new Radiocommunication Act and the General Radio Regulations. The objective of this new strategy is to lead to a transparent licensing scheme for the end user, which in turn could lead to license exemption of blanket licenses as soon as possible.

75 FR 81628 - Government-Owned Inventions; Availability for Licensing

Science.gov (United States)

2010-12-28

... National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), part of the National Institute of... 2010 (HHS Reference No. E-116-2010/0-US-01). Licensing Status: Available for licensing. Licensing...; [email protected] . Collaborative Research Opportunity: The National Institute of Diabetes and...

48 CFR 52.227-19 - Commercial Computer Software License.

Science.gov (United States)

2010-10-01

... Software License. 52.227-19 Section 52.227-19 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.227-19 Commercial Computer Software License. As prescribed in 27.409(g), insert the following clause: Commercial Computer Software License (DEC 2007) (a) Notwithstanding any contrary provisions...

License - Yeast Interacting Proteins Database | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Yeast Interacting Proteins Database License to Use This Database Last updated : 2010/02/15 You may use this database...nal License described below. The Standard License specifies the license terms regarding the use of this database... and the requirements you must follow in using this database. The Additional ...the Standard License. Standard License The Standard License for this database is the license specified in th...e Creative Commons Attribution-Share Alike 2.1 Japan . If you use data from this database

Recent developments in Canadian nuclear power plant licensing practices

International Nuclear Information System (INIS)

Marchildon, P.

1985-06-01

This paper examines the dominant factors which have influenced the safety evaluation and licensing process of current 600 MW reactors. It describes possible modifications to the process which are being considered for the licensing of a second 600 MW reactor at Point Lepreau. The key element is a firm licensing agreement covering the entire licensing cycle, to be established between the proponent and the AECB before a construction licence is issued. Progress accomplished to date in reaching such an agreement is described

Licensing of the Ignalina NPP

International Nuclear Information System (INIS)

Kutas, S.

1999-01-01

Since 1991 State Nuclear Power Safety Inspectorate (VATESI) has regulated Ignalina NPP operation by issuing annual operating permits. Those have been issued following submission of specified documents by the Ignalina NPP that have been reviewed by VATESI. However, according to to the procedures that are now established in the Law on Nuclear Energy and subordinate regulations the use of nuclear energy in the Republic of Lithuania is subject to strict licensing. Therefore a decision about the licence for continued operation of unit 1 should be taken. Licence would be granted by VATESI in cooperation with the Ministry of Health, Ministry of Environment and the institutions of local authorities. Ignalina NPP presented to the VATESI safety analysis report (SAR) with other documents. SAR was made mainly by foreign experts and financed by European Bank for Reconstruction and Development (EBRD). VATESI in this process is supported by western regulators. A special project LAP - Licensing Assistance Project was launched to help VATESI perform licensing according western practices

MATLAB Software Versions and Licenses for the Peregrine System |

Science.gov (United States)

High-Performance Computing | NREL MATLAB Software Versions and Licenses for the Peregrine System MATLAB Software Versions and Licenses for the Peregrine System Learn about the MATLAB software Peregrine is R2017b. Licenses MATLAB is proprietary software. As such, users have access to a limited number

LicenseScript: A Logical Language for Digital Rights Management

NARCIS (Netherlands)

Chong, C.N.; Corin, R.J.; Doumen, J.M.; Etalle, Sandro; Hartel, Pieter H.; Law, Y.W.; Tokmakoff, Andrew

We propose LicenseScript, a language for digital rights management (DRM) based on multiset rewriting and logic programming. LicenseScript enjoys a precise syntax and semantics, and it is rich enough to embed other rights expression languages (REL). We show that LicenseScript is expressive and

Greenland unveils terms for offshore licenses

International Nuclear Information System (INIS)

Anon.

1992-01-01

This paper reports that Greenland has spelled out terms for its first round of offshore licensing. The action off western Greenland could lead to the first oil and gas exploration there since an unsuccessful campaign in the 1970s. The Mineral Resources Administration (MRA) for Greenland pegged exploration license terms on 133 blocks, all south of the 66th parallel, at 10 years with options for 2 year extensions to a maximum of 6 more years. The license can cover as many as six blocks. In the first 3 year period companies will have only a seismic obligation of 1,588 km per six blocks. For the second 3 year period there will be a one well obligation and one well in each subsequent 2 year periods

License - CREATE portal | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us CREATE portal License License to Use This Database Last updated : 2016/03/16 You may use this database... the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attribu...tion-Share Alike 4.0 International . If you use data from this database, please be sure attribute this database...hare Alike 4.0 International is found here . With regard to this database, you are licensed to: freely acces

Operating reactors licensing actions summary. Vol. 3, No. 6

International Nuclear Information System (INIS)

1983-07-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

Operating reactors licensing actions summary. Volume 5, No. 6

International Nuclear Information System (INIS)

1985-08-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Resource Management. This summary report is published for internal NRC use in managing the Operating Reactors Licensing Actions Program. Its content will change based on NRC management informational requirements

Non-Power Reactor Operator Licensing Examiner Standards. Revision 1

International Nuclear Information System (INIS)

1995-06-01

The Non-Power Reactor Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

Non-Power Reactor Operator Licensing Examiner Standards. Revision 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-06-01

The Non-Power Reactor Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience.

Licensed bases management for advanced nuclear plants

Energy Technology Data Exchange (ETDEWEB)

O' Connell, J. [Duke Engineering and Services, Marlborough, MA (United States); Rumble, E.; Rodwell, E. [EPRI, Palo Alto, CA (United States)

2001-07-01

Prospective Advanced Nuclear Plant (ANP) owners must have high confidence that the integrity of the licensed bases (LB) of a plant will be effectively maintained over its life cycle. Currently, licensing engineers use text retrieval systems, database managers, and checklists to access, update, and maintain vast and disparate licensing information libraries. This paper describes the demonstration of a ''twin-engine'' approach that integrates a program from the emerging class of concept searching tools with a modern Product Data Management System (PDMS) to enhance the management of LB information for an example ANP design. (author)

A Real-time License Plate Detection System for Parking Access

Directory of Open Access Journals (Sweden)

Roenadi Koesdijarto

2010-08-01

Full Text Available The automatic and real-time license plate detection system can be used as an access control entry of vehicles into the parking area. The problem is how to recognize the vehicles that will go into the parking lot and how to recognize various types of license plates in various light conditions quickly and accurately. In this research, the prototype was developed with a detection system to recognize the vehicles that will enter the parking area, and a license plate recognition system. In the license plate recognition system, the Fourier transform and Hidden Markov model method have proposed to detect location of license plate and as characters segmentation to recognize Indonesia license plates. The research results have shown that the developed prototype system has successfully recognized all Indonesia license plates in several of light condition and camera position. The percentage of plate recognition in the real-time experiment is 84.38%, and the average execution time for all recognition process is 5.834 second.

Integration of MGDS design into the licensing process

International Nuclear Information System (INIS)

1997-12-01

This paper presents an overview of how the Mined Geologic Disposal System (MGDS) design for a potential repository is integrated into the licensing process. The integration process employs a two-told approach: (1) ensure that the MGDS design complies with applicable Nuclear Regulatory Commission (NRC) licensing requirements, and (2) ensure that the MGDS design is appropriately reflected in a license application that is acceptable to the NRC for performing acceptance and compliance reviews

75 FR 32773 - Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7...

Science.gov (United States)

2010-06-09

..., depending upon the bidding activity for the license. Equations and examples are shown in Attachment B of the.... Balancing the potential need for bidders to use withdrawals to avoid winning incomplete combinations of...

Current safety issues of CANDU licensing

International Nuclear Information System (INIS)

Lee, Y.; Natalizio, A.

1994-01-01

As requested by Korea Institute of Nuclear Safety(KINS), the status of five generic licensing issues has been examined and their potential impact on a new plant that would be constructed in Canada has been evaluated. The results and conclusions of this evaluation are summarized as follows: steam explosion in calandria, hydrogen explosion in containment, use of PSA in reactor licensing, human factors, safety critical software

License - Metabolonote | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Metabolonote License License to Use This Database Last updated : 2016/06/22 You may use this database...the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attribut...ion-Share Alike 4.0 International . If you use data from this database, please be sure attribute this database...e Creative Commons Attribution-Share Alike 4.0 International is found here . With regard to this database

78 FR 20106 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2013-04-03

... M. Tsai, President (QI). Application Type: New NVO License. American International Shipping Company... Type: New NVO License. Nippon Concept America, LLC (OFF), 2203 Timberloch Place, Suite 218D, The...

15 CFR 732.4 - Steps regarding License Exceptions.

Science.gov (United States)

2010-01-01

... General Prohibition Six (Embargo), consult part 746 of the EAR for applicable License Exceptions. (b... export or reexport is subject to General Prohibition Six (Embargo) for embargoed destinations, License...

48 CFR 1852.225-70 - Export Licenses.

Science.gov (United States)

2010-10-01

... writing, that the Contracting Officer authorizes it to export ITAR-controlled technical data (including... licenses or other approvals, if required, for exports of hardware, technical data, and software, or for the provision of technical assistance. (b) The Contractor shall be responsible for obtaining export licenses, if...

Licensing of HTGRs in the United States

International Nuclear Information System (INIS)

Fisher, C.R.; Orvis, D.D.

1981-01-01

The licensing history of the high-temperature gas-cooled reactor (HTGR) in the United States is given historical perspective. The experience began with the licensing of the Peach Bottom Atomic Power Station and extends to the continuing experience at the Fort St. Vrain Nuclear Generating Station. Additional experience was obtained from the licensing reviews in the mid-1970s of the large HTGR plants that were to be built by Philadelphia Electric Company and Delmarva Power and Light. Also, information was provided by the licensing review of the General Atomic standard plant by the U.S. Nuclear Regulatory Commission (NRC) at about the same time. These experiences are summarized in terms of the principal design criteria that were required by the regulatory authority for each project. These criteria include specification of the design basis accidents that were postulated for the plant safety analysis. Several technical issues raised by the NRC during their review of the large HTGR are presented. (author)

Generational differences among newly licensed registered nurses.

Science.gov (United States)

Keepnews, David M; Brewer, Carol S; Kovner, Christine T; Shin, Juh Hyun

2010-01-01

Responses of 2369 newly licensed registered nurses from 3 generational cohorts-Baby Boomers, Generation X, and Generation Y-were studied to identify differences in their characteristics, work-related experiences, and attitudes. These responses revealed significant differences among generations in: job satisfaction, organizational commitment, work motivation, work-to-family conflict, family-to-work conflict, distributive justice, promotional opportunities, supervisory support, mentor support, procedural justice, and perceptions of local job opportunities. Health organizations and their leaders need to anticipate intergenerational differences among newly licensed nurses and should provide for supportive working environments that recognize those differences. Orientation and residency programs for newly licensed nurses should be tailored to the varying needs of different generations. Future research should focus on evaluating the effectiveness of orientation and residency programs with regard to different generations so that these programs can be tailored to meet the varying needs of newly licensed nurses at the start of their careers. Copyright 2010 Mosby, Inc. All rights reserved.

Licensing of HTGRs in the United States

Energy Technology Data Exchange (ETDEWEB)

Fisher, C. R.; Orvis, D. D. [General Atomic Co., San Diego, CA (USA)

1981-01-15

The licensing history of the high-temperature gas-cooled reactor (HTGR) in the United States is given historical perspective. The experience began with the licensing of the Peach Bottom Atomic Power Station and extends to the continuing experience at the Fort St. Vrain Nuclear Generating Station. Additional experience was obtained from the licensing reviews in the mid-1970s of the large HTGR plants that were to be built by Philadelphia Electric Company and Delmarva Power and Light. Also, information was provided by the licensing review of the General Atomic standard plant by the U.S. Nuclear Regulatory Commission (NRC) at about the same time. These experiences are summarized in terms of the principal design criteria that were required by the regulatory authority for each project. These criteria include specification of the design basis accidents that were postulated for the plant safety analysis. Several technical issues raised by the NRC during their review of the large HTGR are presented.

An Edge-Based Macao License Plate Recognition System

Directory of Open Access Journals (Sweden)

Chi-Man Pun

2011-04-01

Full Text Available This paper presents a system to recognize Macao license plates. Sobel edge detector is employed to extract the vertical edges, and an edge composition algorithm is proposed to combine the edges into candidate plate regions. They are further examined on the existence of the character qMq by a verification algorithm. A row separation algorithm is also proposed to cater both one-row and two-row types of plates. Projection analysis and template matching methods are exploited to segment and recognize the characters. Various pre and post processing steps are proposed other than traditional implementation so as to improve the recognition accuracy. This work achieves a high recognition rate of 95%.

License - Society Catalog | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Society Catalog License License to Use This Database Last updated : 2012/01/17 You may use this database...es the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attri...bution-Share Alike 2.1 Japan . If you use data from this database, please be sure attribute this database as...is found here . With regard to this database, you are licensed to: freely access part or whole of this database

The Licensing of New Nuclear Power Plants in Europe

International Nuclear Information System (INIS)

Raetzke, C.

2008-01-01

After an introduction dealing with the nuclear Renaissance in Europe and the specific situation of Germany and of Italy, the article focuses on the question of licensing processes for new reactors. New nuclear power plant projects involve a substantial investment and electric utilities will only take this decision if the licensing and regulatory risk can be adequately managed. Licensing processes should be predictable and efficient in order to give sufficient assurance to applicants. The article discusses best practice in licensing by giving some examples of suitable licensing processes of other countries. It also highlights international initiatives aimed at harmonizing safety requirements for new reactors and a multinational cooperation in reactor design review. These issues should be carefully considered by any country wanting to get new nuclear started. [it

New Jersey's license plate decal requirement for graduated driver licenses: attitudes of parents and teenagers, observed decal use, and citations for teenage driving violations.

Science.gov (United States)

McCartt, Anne T; Oesch, Nathan J; Williams, Allan F; Powell, Tara Casanova

2013-01-01

On May 1, 2010, New Jersey implemented a law requiring teenagers with learner's permits or probationary licenses to display reflective decals on the front and rear license plates when they drive. The current study examined attitudes of parents and teenagers toward this requirement, use of decals, and reported violations and police enforcement of the graduated driver license law. Statewide telephone surveys of representative samples of parents and teenagers were conducted in February to April 2010 and March to June 2011. Use of decals among probationary license holders was observed at 4 high schools in fall 2010 and in spring 2011 and hand-out surveys were distributed. Data on citations issued for violations of the graduated driver license law were obtained. When interviewed in spring 2011, a large majority of parents of probationary license holders, parents of learner's permit holders, and teenagers with probationary licenses disapproved of decals for probationary licenses. About two thirds of both sets of parents and about half of teenagers disapproved of decals for learner's permits. Support for decals for both license types declined significantly from 2010 to 2011. For parents and teenagers alike, opposition was mainly attributed to concern about identifying and/or targeting teenage drivers by other drivers, predators, or police. In 2011, 77 percent of parents of probationary license holders said that their teenagers had decals for the vehicles driven most often; 46 percent said their teenagers always used decals. Fifty-six percent of parents of learner's permit holders said that their teenagers had decals for the vehicles driven most often; 37 percent said that their teenagers always used decals. Teenagers' reported violations of license restrictions either increased or were similar in 2011 compared to 2010. Observed rates of decal use by probationary license holders at high schools in spring 2011 ranged from 24 to 64 percent. The number of statewide citations

Licensing biotech intellectual property in university-industry partnerships.

Science.gov (United States)

Drozdoff, Vladimir; Fairbairn, Daryl

2015-01-20

Appropriate negotiation and drafting of license agreements are critical to successfully establishing and managing the expansive and complex relationships that are becoming more common between industry and universities. More often than not, the resulting licensing agreements become quite lengthy and complex, and the key principles become difficult to discern among all the details. This summary provides a short, nonexhaustive introduction to some of the essential components of these licenses with the intent of providing the non-licensing professional a better appreciation of some of the key commercial and legal terms from both an academic and company perspective, keeping in mind some of the considerations that particularly apply to biotechnology deals. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

The licensing of nuclear power plants in Brazil

International Nuclear Information System (INIS)

Lederman, L.

1980-01-01

In Brazil the governmental organization responsible for the licensing of NPPs is the Comissao Nacional de Energia Nuclear (CNEN), the Brazilian Regulatory Body. A description of CNEN's organization, responsabilities and working methods, as well as the present situation of the Brazilian NPPs undergoing licensing, has recently been presented. In this paper the experience gained by CNEN in the course of licensing Brazilian NPPs Units I and II is discussed. CNEN's present day technical competence and its future trends are analysed with regard to in-house capacity, foreign consultants and research contracts with Brazilian Universities. Finally, the immediate need for a Safety research programm in support of licensing is discussed. Manpower needs and major areas for such a programm are also indicated. (orig./RW)

Licensing and Environmental Issues of Wave Energy Projects

DEFF Research Database (Denmark)

Neumann, Frank; Tedd, James; Prado, Miguel

2006-01-01

a special standing or facilitated access to operating licenses due to their experimental character, the move of wave energy projects towards commercial applications implies complex procedures for obtaining licenses both with respect to the construction and deployment and operation phases, as well......The major non-technical barrier for large-scale wave energy implementation is the wide range of licensing issues and potential environmental concerns, in addition to significant National/regional differences in licensing procedures and permit requirements. Whereas some pilot plants have had...... as concerning ocean space use and environmental concerns. Despite recent efforts to streamline European EIA (Environmental Impact Assessment) in general, potential project developers are far from having a clear view of present and future requirements concerning these barriers on a trans-national level...

77 FR 64992 - Ocean Transportation Intermediary License Reissuances

Science.gov (United States)

2012-10-24

..., Kenner, LA 70062. Date Reissued: August 15, 2012. License No.: 020088N. Name: Hal-Mari International... 91754. Date Reissued: September 5, 2012. License No.: 019372F. Name: Hal-Mari International Logistics...

77 FR 40882 - Ocean Transportation Intermediary License; Revocations

Science.gov (United States)

2012-07-11

...: Voluntarily surrendered license. License Number: 021243NF. Name: Cargo Logistics & Trade Solutions, Limited Liability Company. Address: 13367 NW 47th Avenue, Opa Locka, FL 33054. Date Revoked: May 26, 2012. Reason...

The mutational profile and infiltration pattern of murine MLH1-/- tumors: concurrences, disparities and cell line establishment for functional analysis.

Science.gov (United States)

Maletzki, Claudia; Beyrich, Franziska; Hühns, Maja; Klar, Ernst; Linnebacher, Michael

2016-08-16

Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D, the biallelic form. MMR-D knockout mice may be representative for both diseases. Here, we aimed at characterizing the MLH1-/- model focusing on tumor-immune microenvironment and identification of coding microsatellite mutations in lymphomas and gastrointestinal tumors (GIT).All tumors showed microsatellite instability (MSI) in non-coding mononucleotide markers. Mutational profiling of 26 coding loci in MSI+ GIT and lymphomas revealed instability in half of the microsatellites, two of them (Rfc3 and Rasal2) shared between both entities. MLH1-/- tumors of both entities displayed a similar phenotype (high CD71, FasL, PD-L1 and CTLA-4 expression). Additional immunofluorescence verified the tumors' natural immunosuppressive character (marked CD11b/CD200R infiltration). Vice versa, CD3+ T cells as well as immune checkpoints molecules were detectable, indicative for an active immune microenvironment. For functional analysis, a permanent cell line from an MLH1-/- GIT was established. The newly developed MLH1-/- A7450 cells exhibit stable in vitro growth, strong invasive potential and heterogeneous drug response. Moreover, four additional MSI target genes (Nktr1, C8a, Taf1b, and Lig4) not recognized in the primary were identified in this cell line.Summing up, molecular and immunological mechanisms of MLH1-/- driven carcinogenesis correlate well with clinical features of MMR-D. MLH1-/- knockout mice combine characteristics of Lynch syndrome and constitutional MMR-D, making them suitable models for preclinical research aiming at MMR-D related diseases.

13 CFR 107.1900 - Surrender of license.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Surrender of license. 107.1900 Section 107.1900 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Ending Operations as a Licensee § 107.1900 Surrender of license. You may not surrender your...

22 CFR 120.21 - Manufacturing license agreement.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Manufacturing license agreement. 120.21 Section... DEFINITIONS § 120.21 Manufacturing license agreement. An agreement (e.g., contract) whereby a U.S. person grants a foreign person an authorization to manufacture defense articles abroad and which involves or...

Licensing activities for advanced reactors in NNC

International Nuclear Information System (INIS)

Chevalier, A.B.H.; Mustoe, J.; Walters, J.; Ingham, E.L.

2001-01-01

NNC has been involved in safety and licensing activities for advanced reactors for many years. Most recently NNC has been involved with national regulators or their representatives for the HTR (High Temperature Reactor) reactor and the possible siting of ITER (International Thermonuclear Experimental Reactor) within Europe. Commonalties between the two activities can be seen, even though one is a fission process and the other based on a completely new technology. Both have the potential to generate power at a very low overall exposure to the public and station staff, but both also need to demonstrate to the regulator the safety of a design which differs from the standard LWR practice. In both concepts passive design features provide a major part of the safety argument, but the detailed assessment and justification of these features in licensing terms still needs to be made. A number of critical safety issues can be identified, which generally apply to any advanced system. These are: Safety categorization, codes and standards; confinement or containment; ALARA; safety code modelling and data; Occupational Exposure; occupational exposures; decommissioning and waste; no evacuation, or no emergency plans. The UK is notable for a flexible licensing regime, which allows a safety case to be built up from first principles, where this is applicable. In addition, experience of licensing gas cooled, water cooled and liquid metal plant, as well as extensive experience outside the UK provides NNC with a unique insight into the different licensing methodologies which can be applied in the licensing process. This paper discusses some possible approaches which could be applied in order to satisfy regulatory demands when addressing the critical issues listed above. (author)

Aging baby boomers--a blessing or challenge for driver licensing authorities.

Science.gov (United States)

Dobbs, Bonnie M

2008-08-01

In less than 5 years, the first wave of baby boomers will begin turning 65, with the last wave of boomers entering their senior years in January 2029. Currently, boomers make up a significant percentage of the population in Canada, the United States, and other developed countries. The baby boom generation has had a profound impact on our society over the last six decades, and this large cohort will continue to exert its influence for several decades to come. Central to this article is the rapid growth in the number of persons 65 years of age and older, beginning in 2011, with a corresponding increase in the number of older drivers. The demographic shift has important implications for licensing authorities, the regulatory bodies charged with licensing and 'fitness to drive' decisions. The objectives of this paper are to summarize the published scientific literature on licensing policies and procedures currently in use for older drivers, discuss their limitations, and provide recommendations for meeting the upcoming challenges of an aging baby boomer population of drivers. Online searches were conducted using the following databases: PsycINFO, MEDLINE, Scopus, and TRIS. Google and Google Scholar also were searched for scientific articles. References identified from database and online searches were examined for relevant articles. A number of studies have investigated the utility of different licensing policies and procedures for identifying older drivers who may be at risk for impaired driving performance. Overall, results suggest that current policies and procedures are ineffective in identifying high-risk older drivers. The results also emphasize the need for a different approach for the identification of high risk older drivers by licensing agencies. Recommendations to assist with that goal are provided. The aging of the baby boomer population, combined with the projected high crash rates for this cohort of drivers as it moves through the senior years, underscores

Operating reactors licensing actions summary. Volume 5, No. 7

International Nuclear Information System (INIS)

1985-09-01

The Operating Reactors Licensing Actions Summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Resource Management

Experience acquired by Furnas for licensing nuclear power plants

International Nuclear Information System (INIS)

Silva, A.J.C. da; Xavier, E.E.

1986-01-01

The system for licensing of Almirante Alvaro Alberto Nuclear Power Plant-Unit 1 is presented. The process phases for reactor construction and operation are described: preliminary site approval; bases for safety review; partial construction permits; final construction permits; emission of final report of safety analysis; initial operation license and permanent operation license. (M.C.K.) [pt

Licensing systems and inspection of nuclear installations

International Nuclear Information System (INIS)

1991-01-01

The first study analysing the regulations governing the licensing and inspection of nuclear installations in OECD countries was published by OECD/NEA in 1980, and revised in 1986. Since then there have been amendments to national regulations on the subject, which have warranted updating of this publication. This new study provides a description of the licensing regulations and practices applied in the twenty OECD countries with provisions in that field. The national systems have been described according to a standard format to make comparisons and research easier. In most cases, the descriptions are supplemented by flow charts illustrating the procedures and specifying the different authorities involved in the licensing procedures [fr

LicenseScript: A Novel Digital Rights Language

NARCIS (Netherlands)

Chong, C.N.; Corin, R.J.; Etalle, Sandro; Hartel, Pieter H.; Law, Y.W.; Grimm, R.; Nitzel, J.

We propose LicenseScript as a new multi-set rewriting/logic based language for expressing dynamic conditions of use of digital assets such as music, video or private data. LicenseScript differs from the other DRM languages in that it caters for the intentional but legal manipulation of data. We

A Meta-Analytic Review of Moral Licensing

NARCIS (Netherlands)

Blanken, Irene; van de Ven, Niels; Zeelenberg, Marcel

2015-01-01

Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397

A meta-analytic review of moral licensing

NARCIS (Netherlands)

Blanken, I.; van de Ven, N.; Zeelenberg, M.

2015-01-01

Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397

45 CFR 1321.75 - Licenses and safety.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Licenses and safety. 1321.75 Section 1321.75... AND COMMUNITY PROGRAMS ON AGING Service Requirements § 1321.75 Licenses and safety. The State shall... that the facility complies with all applicable State and local health, fire, safety, building, zoning...

21 CFR 515.20 - Approval of medicated feed mill license applications.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Approval of medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.20 Approval of medicated feed mill license applications. Within 90 days after an...

21 CFR 515.23 - Voluntary revocation of medicated feed mill license.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Voluntary revocation of medicated feed mill... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.23 Voluntary revocation of medicated feed mill license. A license issued under...

47 CFR 80.53 - Application for a portable ship station license.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a portable ship station license... SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.53 Application for a portable ship station license. The Commission may grant a license permitting operation of a...

PROCESS FOR LICENSE APPLICATION DEVELOPMENT FOR THE GEOLOGIC REPOSITORY

International Nuclear Information System (INIS)

DOUGLAS M. FRANKS AND NORMAN C. HENDERSON

1997-01-01

The Department of Energy (DOE), specifically the Office of Civilian Radioactive Waste Management (OCRWM) has been charged by the U.S. Congress, through the Nuclear Waste Policy Act (NWPA), with the responsibility for obtaining a license to develop a geologic repository. The NRC is the licensing authority for geologic disposal, and its regulations pertinent to construction authorization and license application are specified in 10 CFR Part 60, Disposal of High-Level Radioactive Wastes in Geologic Repositories, (section)60.21ff and (section)60.31ff. This paper discusses the process the Yucca Mountain Site Site Characterization Project (YMP) will use to identify and apply regulatory and industry guidance to development of the license application (LA) for a geologic repository at Yucca Mountain, Nevada. This guidance will be implemented by the ''Technical Guidance Document for Preparation of the License Application'' (TGD), currently in development

Process for license application development for the geologic repository

International Nuclear Information System (INIS)

Franks, D.M.; Henderson, N.C.

1998-01-01

The Department of Energy (DOE), specifically the Office of Civilian Radioactive Waste Management (OCRWM) has been charged by the US Congress, through the Nuclear Waste Policy Act (NWPA), with the responsibility for obtaining a license to develop a geologic repository. The NRC is the licensing authority for geologic disposal, and its regulations pertinent to construction authorization and license application are specified in 10 CFR Part 60, Disposal of High-Level Radioactive Wastes in Geologic Repositories, section 60.21ff and section 60.31ff. This paper discusses the process the Yucca Mountain Site Characterization Project (YMP) will use to identify and apply regulatory and industry guidance to development of the license application (LA) for a geologic repository at Yucca Mountain, Nevada. This guidance will be implemented by the Technical Guidance Document for Preparation of the License Application (TGD), currently in development

Licensing experience of the HTR-10 test reactor

International Nuclear Information System (INIS)

Sun, Y.; Xu, Y.

1996-01-01

A 10MW high temperature gas-cooled test reactor (HTR-10) is now being projected by the Institute of Nuclear Energy Technology within China's National High Technology Programme. The Construction Permit of HTR-10 was issued by the Chinese nuclear licensing authority around the end of 1994 after a period of about one year of safety review of the reactor design. HTR-10 is the first high temperature gas-cooled reactor (HTGR) to be constructed in China. The purpose of this test reactor project is to test and demonstrate the technology and safety features of the advanced modular high temperature reactor design. The reactor uses spherical fuel elements with coated fuel particles. The reactor unit and the steam generator unit are arranged in a ''side-by-side'' way. Maximum fuel temperature under the accident condition of a complete loss of coolant is limited to values much lower than the safety limit set for the fuel element. Since the philosophy of the technical and safety design of HTR-10 comes from the high temperature modular reactor design, the reactor is also called the Test Module. HTR-10 represents among others also a licensing challenge. On the one side, it is the first helium reactor in China, and there are less licensing experiences both for the regulator and for the designer. On the other side, the reactor design incorporates many advanced design features in the direction of passive or inherent safety, and it is presently a world-wide issue how to treat properly the passive or inherent safety design features in the licensing safety review. In this presentation, the licensing criteria of HTR-10 are discussed. The organization and activities of the safety review for the construction permit licensing are described. Some of the main safety issues in the licensing procedure are addressed. Among these are, for example, fuel element behaviour, source term, safety classification of systems and components, containment design. The licensing experiences of HTR-10 are of

Managing the high level waste nuclear regulatory commission licensing process

International Nuclear Information System (INIS)

Baskin, K.P.

1992-01-01

This paper reports that the process for obtaining Nuclear Regulatory Commission permits for the high level waste storage facility is basically the same process commercial nuclear power plants followed to obtain construction permits and operating licenses for their facilities. Therefore, the experience from licensing commercial reactors can be applied to the high level waste facility. Proper management of the licensing process will be the key to the successful project. The management of the licensing process was categorized into four areas as follows: responsibility, organization, communication and documentation. Drawing on experience from nuclear power plant licensing and basic management principles, the management requirement for successfully accomplishing the project goals are discussed

76 FR 28780 - Ocean Transportation Intermediary License; Revocation

Science.gov (United States)

2011-05-18

... maintain a valid bond. License Number: 020656F. Name: Dulce Auto Import & Export, Inc. Address: 15316 SW... to maintain a valid bond. License Number: 019868N. Name: Zenith Logistic (USA) Inc. Address: 175-01...

DESIGN AND LICENSING TRENDS OF THE GENERAL EDUCATIONAL PROGRAMS IN LATVIA

OpenAIRE

Mihailovs, Ivans Jānis; Krūmiņa, Aira Aija

2016-01-01

The general education program designing and licensing trends in Latvia in the period from 2010 to 2014 are analyzed in the article. Based on the general education program licensing data, it found that there isn’t a trend to license author’s program in primary education, while the secondary level of education author's programs are designed and licensed more often. The fact that primary education is more licensed programs in mathematics, science and technology, but in general secondary educatio...

48 CFR 227.7009 - Patent releases, license agreements, and assignments.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Patent releases, license... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7009 Patent releases, license agreements, and...

Groundfish/Crab License Limitation Program (LLP) Permit Program

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — As of January 1, 2000 a Federal License Limitation Program (LLP) license is required for vessels participating in directed fishing for LLP groundfish species in the...

Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome

Directory of Open Access Journals (Sweden)

Buchanan DD

2014-10-01

data from published studies are combined, 59% (95% confidence interval [CI]: 55% to 64% of colorectal cancers and 52% (95% CI: 41% to 62% of endometrial cancers with MMR deficiency were identified as suspected Lynch syndrome. Recent studies estimated that colorectal cancer risk for relatives of suspected Lynch syndrome cases is lower than for relatives of those with MMR gene mutations, but higher than for relatives of those with tumor MMR deficiency resulting from methylation of the MLH1 gene promoter. The cause of tumor MMR deficiency in suspected Lynch syndrome cases is likely due to either unidentified germline MMR gene mutations, somatic cell mosaicism, or biallelic somatic inactivation. Determining the underlying cause of tumor MMR deficiency in suspected Lynch syndrome cases is likely to reshape the current triaging schemes used to identify germline MMR gene mutations in cancer-affected individuals and their relatives.Keywords: Lynch syndrome, cancer risk, screening, somatic mutation, germline mutation

48 CFR 252.227-7005 - License term.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License term. 252.227-7005..., DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And... referred to in the “License Grant” clause of this contract and any and all patents hereafter issued on...

22 CFR 129.6 - Requirement for license/approval.

Science.gov (United States)

2010-04-01

... LICENSING OF BROKERS § 129.6 Requirement for license/approval. (a) No person may engage in the business of... member country of that Organization, Australia, Japan, New Zealand, or South Korea, except in the case of...

Open Science: Open source licenses in scientific research

OpenAIRE

Guadamuz, Andres

2006-01-01

The article examines the validity of OSS (open source software) licenses for scientific, as opposed to creative works. It draws on examples of OSS licenses to consider their suitability for the scientific community and scientific research.

A new license plate extraction framework based on fast mean shift

Science.gov (United States)

Pan, Luning; Li, Shuguang

2010-08-01

License plate extraction is considered to be the most crucial step of Automatic license plate recognition (ALPR) system. In this paper, a region-based license plate hybrid detection method is proposed to solve practical problems under complex background in which existing large quantity of disturbing information. In this method, coarse license plate location is carried out firstly to get the head part of a vehicle. Then a new Fast Mean Shift method based on random sampling of Kernel Density Estimate (KDE) is adopted to segment the color vehicle images, in order to get candidate license plate regions. The remarkable speed-up it brings makes Mean Shift segmentation more suitable for this application. Feature extraction and classification is used to accurately separate license plate from other candidate regions. At last, tilted license plate regulation is used for future recognition steps.

The nuclear licensing and supervisory procedures for nuclear facilities in the Federal Republic of Germany

International Nuclear Information System (INIS)

Franzen, L.F.

1982-02-01

A combined system has been developed in the Federal Republic of Germany: the States execute the Atomic Energy Act on behalf of the Federal Government. Despite these differences, the safety requirements and the safety standard achieved vary only insignificantly, as a result of a world-wide communication and of international cooperation. The legal prerequesites for the German nuclear licensing procedures have been established about 20 years ago, and, by a number of amendments have been adapted to new perceptions and developments. Several supplementary ordinances, due to further developments in nuclear technology, are being prepared. The work on associated technical provision, which had been neglected for a long time, has in recent years been tackled systematically and should, before long, lead to a comprehensive programme of safety standards, which simplifies and expedites the nuclear licensing procedures. Essential features of the licensing procedure are the phased structure and the division into intermediate steps which render it possible to adapt the safety requirements to the advancing state of science and technology. The responsible authorities call in experts for the safety verification of the application documents. It is the task of these experts to make assessments and to conduct quality examinations in the manufacturing plants and at the site, and to carry out recurrent tests. The public is involved by the announcement of the projects, the display of the documents and by the opportunity to raise objections during the licensing procedure. Licenses granted can be contested before the administrative courts. This procedure paves the way for the achievement of a satisfactory balance between private and public interests. (orig./HP)

Site Specific Vendor's License

Data.gov (United States)

Montgomery County of Maryland — This dataset contains information of a site-specific vendor's license which is required if an individual sells or offers to sell goods or services from a stationary...

The use of U.S. NRC licensing practices for VVERs

International Nuclear Information System (INIS)

Popp, D.M.

2000-01-01

The licensing process for the upgraded Temelin I and C and Fuel designs were enhanced with the introduction of U.S. Nuclear Regulatory Commission, NRC practices. Specifically, the use of the NRC Regulatory Guide 1.70, 'Standard Format and Content Guide for Safety Analyses Reports' and NRC NUREG 0800, 'Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants', were beneficial in the development and review of Temelin licensing documentation. These standards have been used for the preparation and review of Safety Analysis Reports in the United States and also in a large number of licensing applications around the world. Both Regulatory Guide 1.70 and NUREG 0800 were developed to provide a predictable and structured approach to licensing. This paper discusses this approach and identifies the benefits to designers, writers of licensing documentation and reviewers of licensing documents. (author)

Licensing systems and inspection of nuclear installations in NEA Member countries. Part 1, Description of licensing systems

International Nuclear Information System (INIS)

1977-01-01

This study provides an assessment of the legislative and regulatory provisions applicable and of the practices followed in the countries concerned and is divided into two separate sections. This document is the first part only. It contains the description of national licensing and inspection systems for nuclear installations in the twenty OECD countries which have specific regulations in this field. Each analysis has been presented following a plan which is as standardised as possible so as to facilitate comparison between the national systems. Part II, which is not included in this document, contains the diagrams illustrating the steps in the licensing procedure and the duties of the bodies involved as well as certain additional documents. It also includes a table showing the sequence of the main steps in the licensing process in the countries covered by this Study

Aging management review for license renewal and plant life management

International Nuclear Information System (INIS)

Rinckel, M.A.; Young, G.G.

2002-01-01

Full text: United States nuclear power plants are initially licensed for a period of 40-years. The 40-year term, which was established by the Atomic Energy Commission in the 1950s, is believed to be based on engineering judgement and is consistent with the typical amortization schedule for purchasing fossil power plants. Under 10 CFR Part 54, the license renewal rule, additional terms of 20-years may be obtained through the preparation of a license renewal application that must be reviewed and approved by the Nuclear Regulatory Commission (NRC). The license renewal rule requires that applicants perform ageing management reviews on passive long-lived structures and components to demonstrate that ageing will be managed during the period of extended operation (i.e., additional 20 years of operation). ageing of active components, which are excluded from 10 CFR Part 54, is accomplished through the Maintenance Rule, 10 CFR Part 65, using performance-based monitoring. The license renewal rule, 10 CFR Part 54, was initially published in 1991. After significant interaction with the nuclear industry from 1991 through 1994, the NRC revised the rule in 1995 to focus on passive long-lived structures and components. In 1998, the first two applications for license renewal were submitted to the NRC by Baltimore Gas and Electric for the two-unit Calvert Cliffs nuclear power plant and by Duke Energy for the three-unit Oconee nuclear power plant. In March 2000, the NRC approved the application for the two-unit Calvert Cliffs nuclear power plant for an additional 20 years. Two months later, the NRC approved the renewal of the operating licenses for the three-unit Oconee nuclear station. The NRC completed these reviews in a timely, predictable, and stable manner. As of February 2002, the NRC has approved renewal of operating licenses for eight nuclear units and has applications under review for 15 more units. Twelve additional companies have notified the NRC of their intention to seek

License - PLACE | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us PLACE License License to Use This Database Last updated : 2014/07/17 You may use this database...ense terms regarding the use of this database and the requirements you must follow in using this database. The license for this datab...re Alike 2.1 Japan. If you use data from this database, please be sure attribute this database as follows: ... ...re . With regard to this database, you are licensed to: freely access part or whole of this database, and ac...quire data; freely redistribute part or whole of the data from this database; and freely create and distribute database

License - RMG | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us RMG License License to Use This Database Last updated : 2013/08/07 You may use this database...se terms regarding the use of this database and the requirements you must follow in using this database. The license for this databas... Alike 2.1 Japan. If you use data from this database, please be sure attribute this database as follows: Ric...Japan is found here . With regard to this database, you are licensed to: freely access part or whole of this database..., and acquire data; freely redistribute part or whole of the data from this database; and freely create and distribute datab

10 CFR 51.97 - Final environmental impact statement-materials license.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Final environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Final Environmental Impact Statements-Materials Licenses § 51.97 Final environmental impact statement—materials license. (a) Independent spent fuel storage installation (ISFSI...

78 FR 48458 - Notice of Reinstatement of Customs Broker License

Science.gov (United States)

2013-08-08

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Reinstatement of Customs Broker License AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: Reinstatement of customs broker license. SUMMARY: Notice is hereby given that a customs broker's license has...

Nuclear power plant licensing: opportunities for improvement

International Nuclear Information System (INIS)

1977-06-01

On April 20, 1977, the Commission directed that recently completed licensing actions be reviewed by the staff for the purpose of identifying ways to improve the effectiveness and efficiency of NRC nuclear power plant licensing activities. This report summarizes the results of a study undertaken by an internal ad hoc Study Group established in response to that directive. The Study Group limited its considerations to safety and environmental review activities. The background, scope, assumptions and objectives of the study are discussed. A prime assumption of this study was that improvements in the efficiency should not be permitted to reduce the current quality achieved in the licensing process. This consideration underlies the conclusions and recommendations of the study

75 FR 46938 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2010-08-04

... Logistics LLC (NVO), 120 S. Woodland Blvd., 216, DeLand, FL 32720, Officers: Dietmar Lutte, Manager Member, (Qualifying Individual), Susan Lutte, Member, Application Type: New NVO License. Bridgeline Logistics..., (Qualifying Individual), Application Type: New OFF License. [[Page 46939

Foundation for the adequacy of the licensing bases

International Nuclear Information System (INIS)

1991-12-01

The objective of this report is to describe the regulatory processes that assures that any plant-specific licensing bases will provide reasonable assurance that the operation of nuclear power plants will not be inimical to the public health and safety to the end of the renewal period. It is on the adequacy of this process that the Commission has determined that a formal renewal licensing review against the full range of current safety requirements would not add significantly to safety and is not needed to assure that continued operation throughout the renewal term is not inimical to the public health and safety or common defense and security. This document illustrates in general terms how the regulatory process has evolved in major safety issue areas. It also provides examples illustrating why it is unnecessary to re-review an operating plant's basis, except for age-related degradation unique to license renewal, at the time of license renewal. The report is a supplement to the Statement of Considerations for the Nuclear Regulatory Commission's rule (10 CFR Part 54) that established the criteria and standards governing nuclear power plant license renewal

Variations in teenage activities with and without a driver's license.

Science.gov (United States)

Preusser, D F; Leaf, W A; Ferguson, S A; Williams, A F

2000-01-01

High school students were surveyed every 6 months from their freshman through senior years concerning licensing, driving, and transportation to and from their various activities. Students in Delaware (learner's permit can be issued at age 15 years, 10 months; driver's license at age 16) were compared with students in Connecticut and New York (permit at age 16; license at age 16) and in New Jersey (license at age 17). During the junior year, most Delaware students, some New York and Connecticut students, and few New Jersey students were licensed. However, even during the junior year, students in the respective states did not differ significantly with respect to time spent at activities such as a paying job, homework, watching television, dating, parties, being with friends, talking on the phone, or participating in sports or school activities. Graduated licensing systems can delay full-privilege teenage licensure and reduce teenage crash rates. These systems also can increase the number of times parents and others must drive. However, the present study's results indicate that licensing delays of as much as 1 year have minimal effects on the nondriving activities of high school students.

Licensing the Sun

Science.gov (United States)

Demski, Jennifer

2013-01-01

The University of San Diego (USD) and Point Loma Nazarene University (PLNU) are licensing the sun. Both California schools are generating solar power on campus without having to sink large amounts of capital into equipment and installation. By negotiating power purchasing agreements (PPAs) with Amsolar and Perpetual Energy Systems, respectively,…

Towards a standard licensing scheme for the access and use of satellite earth observation data for disaster management

DEFF Research Database (Denmark)

Clark, Nathan E.

2017-01-01

using, sharing and combining datasets in an effective and timely manner. It also creates uncertainty among data providers as to the types of licensing controls that should be applied in disaster scenarios. This paper builds from an ongoing comparative analysis of the common and conflicting conditions...

Nuclear licensing and supervision in Germany

International Nuclear Information System (INIS)

1996-06-01

The legal instrument for implementing the licensing and supervisory procedure is specified by statutory ordinances, guidelines and provisions. The licensing requirements for nuclear power plants on the final storage of radioactive wastes in the federal republic of germany are described. The nuclear facilities are subject to continuous state supervision after they have been granted. The appendix gives a brief account of the most important ordinances relating to the AtG and extracts from the Nuclear Safety Convention. (HP)

77 FR 43600 - Ocean Transportation Intermediary License Reissuances

Science.gov (United States)

2012-07-25

.... License No.: 017267NF. Name: Just In Time Services, Inc. Address: 11380 NW 34th Street, Suite 100, Doral... to section 40901 of the Shipping Act of 1984 (46 U.S.C. 40101). License No.: 016201N. Name: Delta...

47 CFR 25.117 - Modification of station license.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Modification of station license. 25.117 Section 25.117 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses General Application Filing Requirements § 25.117...

Establishment of regulatory framework for the development reactor licensing

International Nuclear Information System (INIS)

Jo, Jong C.; Yune, Young G.; Kim, Woong S.; Ahn, Sang K.; Kim, In G.; Kim, Hho J.

2003-01-01

With a trend that various types of advanced reactor designs are currently under development worldwide, the Korea Atomic Energy Research Institute has been developing an advanced reactor called ' System-integrated Modular Advanced Reactor (SMART)', which is a small sized integral type pressurized water reactor with a rated thermal power of 330 MW. To demonstrate the safety and the performance of the SMART reactor design, the SMART Research and Development Center has embarked to build a scaled-down pilot plant of SMART, called 'SMART-P' with a rated thermal power of 65 MW. In preparation for the forthcoming applications for both construction permit and operating license of SMART-P in the near future, the Korea Institute of Nuclear Safety is developing a new regulatory framework for licensing review of such a development reactor, which covers establishment of licensing process, identification and resolution of technical and safety issues, development of regulatory evaluation or verification-purpose computer codes and analytical methods, and establishment of design-specific, general design and operating criteria, regulations, and associated regulatory guides. This paper presents the current activities for establishing a regulatory framework for the licensing of a research and development reactor. Discussions are made on the SMART-P development program, the current Korean regulatory framework for reactor licensing, the SMART-P licensing-related issues, and the approach and strategy for developing an effective regulatory framework for the SMART-P licensing

Practical issues in structuring seismic licensing and acquisition agreements

International Nuclear Information System (INIS)

Lawrence, M.A.

1999-01-01

Some issues facing the geophysical industry in the area of licensing and acquisition agreements are discussed, focusing on a very large business segment of the industry called 'non-exclusive' seismic data (commonly referred to as SPEC data). A historical perspective of the industry in the Gulf of Mexico is presented, highlighting some important aspects of data licenses. The benefits of licensing three-dimensional data to the exploration industry include: (1) economy of scale, (2) 3-D is more affordable, (3) reduced barriers to entry by independents, and (4) improved success rates and reduced risk. A list of 'SPEC' companies in the Gulf of Mexico is provided and the data licensing process is outlined. There are two basic types of seismic data use licenses. The first is for a single, one-time transaction, and the other (which is more prevalent), covers multiple use licenses contemplated over a period of time. This paper briefly outlined the meaning of some important terms usually found in a license agreement, among them ownership, rights of licensee, term, disclosure to third parties, and transfer. International 'SPEC' programs and the requirements for a successful 'SPEC' program are described. The requirements include: a stable host government, reliable, competitive system of concession offerings, long term scheduled offerings, clear, consistent, and acceptable concession terms to oil and gas companies, and consistent, fair and timely method of evaluating bids and awarding concessions. 001CA9901758

Licensing decisions and safety research related to LMFBR accidents

International Nuclear Information System (INIS)

Denise, R.P.; Speis, T.P.; Kelber, C.N.; Curtis, R.T.

1977-01-01

The licensing approach which ensures adequate protection of the public health and safety against serious accidents is described. This paper describes the role of core melt and core disruptive accidents in the design, safety research, and licensing processes, using the Clinch River Breeder Reactor (CRBR) as a focal point. Major design attention is placed on the prevention of these accidents so that the probability of core melt accidents is reduced to a sufficiently low level that they are not treated as design basis accidents. Additional requirements are placed upon the design to further reduce residual risk. This licensing process is supported by a confirmatory research program designed to provide an independent basis for licensing judgements. It has as a goal the resolution of generic safety issues prior to the establishment of a commercial LMFBR industry. The program includes accident analysis, experiments in materials interactions, aerosol transport and system integrity and planning for new safety test facilities. The problems are approached in a multi-disciplinary functional manner that identifies key safety issues and centralizes efforts to resolve them. The near term objectives of the program support the licensing of the Clinch River Breeder Reactor (CRBR) and the proposed Prototype Large Breeder Reactor (PLBR). The long term objectives of the program support the licensing of commercial LMFBRs during the late 1980's and beyond. This safety research is designed to provide an independent basis for the licensing judgements which must be made by the Nuclear Regulatory Commission

Essays on the economics of licensing nuclear power plants

International Nuclear Information System (INIS)

Cohen, L.R.

1979-01-01

Regulation and licensing of nuclear power plants by the United States Atomic Energy Commission and the United States Nuclear Regulatory Commission are discussed. Chapter 1 overviews the licensing process and issues raised in licensing cases. Based on a sample of plants licensed between 1967 and 1978, a statistical study of the impact of public participation in licensing is performed. The study concludes that public participation has had a major impact on licensing and power-plant costs. The impact is due to a fundamental weakness of the Commissions: their inability to resolve certain issues related to acceptable social risk. The study has important policy implications for reforming the Federal licensing process. Chapter 2 contains an analysis of the Price-Anderson Act, a Federal program for compensating victims of large nuclear accidents. The Price-Anderson Act is placed within the context of generalized federal disaster relief. A model is developed that allows an evaluation programs on the basis of moral hazard and equity principles. Chapter 3 analyzes the Nuclear Regulatory Commission's treatment of its mandatory antitrust review of applicants for nuclear power plants. The main conclusion of the chapter is that the reviews have not addressed the central economic issues of antitrust that are relevant to nuclear power. Instead, the reviews contribute to further cartelization of the electric utility industry. While politically expedient, the reviews are counter-productive to the development of an optimal industry structure

10 CFR 51.80 - Draft environmental impact statement-materials license.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.80 Draft environmental impact statement—materials license. (a) The NRC staff will either prepare a draft environmental...

21 CFR 515.11 - Supplemental medicated feed mill license applications.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Supplemental medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Applications § 515.11 Supplemental medicated feed mill license applications. (a) After approval of a medicated feed...

Use of modeling in repository licensing

International Nuclear Information System (INIS)

McGarry, J.M. III; Echols, F.S.

1995-01-01

A review of the regulatory history of the Nuclear Regulatory Commission (NRC) regulations applicable to the licensing of a geologic repository, as well as a review of NRC administrative (licensing) decisions and federal case law, support the NRC's use of simplified models, in appropriate circumstances, which provide well-documented and reasonably conservative bounding assumptions, together with the use of expert judgement, natural analogues, and other aids to supplement available information, in reaching its reasonable assurance determination whether the public health and safety will be adequately protected if the Yucca Mountain, Nevada site should be licensed for development as a geologic repository. Specific examples are provided to assist the reader to better understand how such qualitative concepts as open-quote reasonable assurance close-quote, open-quote reasonably conservative close-quote, and open-quote adequate close-quote protection are used in an administrative context to resolve technical issues

76 FR 38463 - SAFE Mortgage Licensing Act: Minimum Licensing Standards and Oversight Responsibilities

Science.gov (United States)

2011-06-30

... housing laws that address the dramatic rise in mortgage delinquencies and foreclosures in the residential... regarding the status and employment history of all state-licensed and federally loan originators, as well as...

Credentialing, Licensing, and Education

Science.gov (United States)

... V W X Y Z Credentialing, Licensing, and Education Share: On This Page The Bottom Line Credentials, ... and practices that chiropractors are allowed to perform. Education and Training Professional organizations in some complementary health ...

A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate.

Science.gov (United States)

Wone, B W M; Madsen, P; Donovan, E R; Labocha, M K; Sears, M W; Downs, C J; Sorensen, D A; Hayes, J P

2015-04-01

Metabolic rates are correlated with many aspects of ecology, but how selection on different aspects of metabolic rates affects their mutual evolution is poorly understood. Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection on mass-independent basal metabolic rate (BMR). Then we tested for responses to selection in MMR and correlated responses to selection in BMR. In other lines, we antagonistically selected for mice with a combination of high mass-independent MMR and low mass-independent BMR. All selection protocols and data analyses included body mass as a covariate, so effects of selection on the metabolic rates are mass adjusted (that is, independent of effects of body mass). The selection lasted eight generations. Compared with controls, MMR was significantly higher (11.2%) in lines selected for increased MMR, and BMR was slightly, but not significantly, higher (2.5%). Compared with controls, MMR was significantly higher (5.3%) in antagonistically selected lines, and BMR was slightly, but not significantly, lower (4.2%). Analysis of breeding values revealed no positive genetic trend for elevated BMR in high-MMR lines. A weak positive genetic correlation was detected between MMR and BMR. That weak positive genetic correlation supports the aerobic capacity model for the evolution of endothermy in the sense that it fails to falsify a key model assumption. Overall, the results suggest that at least in these mice there is significant capacity for independent evolution of metabolic traits. Whether that is true in the ancestral animals that evolved endothermy remains an important but unanswered question.

Demarcation of the licensing and supervisory procedures for nuclear engineering installations

International Nuclear Information System (INIS)

Schattke, H.

1986-01-01

The remarks can be summed up under 12 points: 1) The protective purpose outlined in Paragraph 1 No. 2 of the Atomic Energy Law is the top priority for both licensing and regulatory authorities. 2) Both authorities must aim at the best possible prevention of hazards and precautions against risks. 3) The licensing procedures cover applications for licenses, the regulatory procedures check and supervise actual activities. 4) The licensing procedures take precedence in chronology and in substance over the regulatory procedure. 5) The licensing procedure is a preliminary check on the intention to carry out nuclear activities before the event; whereas the regulatory procedure controls the licensee after the event to ensure that the latter's activities really do conform to the framework laid down in the license. 6) The licensing procedure must be verified by state supervision with regard to its prognostic activity. 7) The examination criteria are largely identical for both the authorites. 8) The examination tools for the licensing and regulatory authorities also coincide to a large extent. Legal differences in the possible means of enforcement have no effect in practice. 9) Decisions made by either authority can be either in the licensee's favour or to its disadvantage. Nevertheless, the contents of decisions differ widely between the two authorities. 10) The regulatory authorities execute and prepare the decisions of the licensing authorites. 11) Licensing decisions can be designated static/prognostic, whereas regulatory measures accompany the actual performance of the plant and the operating personnel in a dynamic/controlling manner. 12) Regulatory instructions are usually of a temporary nature, whereas licensing actions are permanent as a rule. (orig.) [de

To License or Not to License Revisited: An Examination of State Statutes Regarding Private Investigators and Digital Examiners

OpenAIRE

Thomas Lonardo; Doug White; Alan Rea

2009-01-01

In this update to the previous year's study, the authors examine statutes that regulate, license, and enforce investigative functions in each US state. After identification and review of Private Investigator licensing requirements, the authors find that very few state statutes explicitly differentiate between Private Investigators and Digital Examiners. After contacting all state agencies the authors present a distinct grouping organizing state approaches to professional Digital Examiner lice...

Licensing schedule for away-from-reactor (AFR) spent fuel storage facilities

International Nuclear Information System (INIS)

Gray, P.L.

1981-08-01

The Nuclear Regulatory Commission has authority to issue licenses for Away-From-Reactor (AFR) installations for the storage of spent nuclear fuel. This report presents a detailed estimate of the time required to prosecute a licensing action. The projected licensing schedule shows that the elapsed time between filing an application and issuance of a license will be about 32 months, assuming intervention. The legal procedural steps will determine the time schedule and will override considerations of technical complexity. A license could be issued in about 14 months in the absence of intervention

License - PGDBj - Ortholog DB | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us PGDBj - Ortholog DB License License to Use This Database Last updated : 2017/03/07 You may use this database...cifies the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons A...ttribution-Share Alike 4.0 International . If you use data from this database, please be sure attribute this database...hare Alike 4.0 International is found here . With regard to this database, you are licensed to: freely acces

75 FR 48686 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2010-08-11

...: New NVO License. Maritime and Intermodal Logistics Systems, Inc. dba MILS dba Fesco Integrated..., Senior Vice President/General Manager (Qualifying Individual), Kenryo Senda, President/CEO, Application...: New NVO & OFF License. Rado International, Inc. dba Rado Logistics (NVO & OFF), 2251 Sylvan Road...

Collegiate Licensing in Canada and the Statutory Advantage.

Science.gov (United States)

Burshtein, Sheldon

1985-01-01

Discusses a specific provision in a Canadian statute enabling universities and other educational institutions to obtain protection and financial gain in a collegiate licensing program, an advantage not held in other countries or by other trademark licensers in Canada. (MSE)

The end game must end before license renewal begins

International Nuclear Information System (INIS)

Allen, S.R.; Edwards, D.W.

1995-01-01

The quest for a process and strategy to achieve license renewal was begun in the mid-1980s with the view that renewal was an imperative. A major portion of the nation's future electric supply seemed to be at stake. For plants who were becoming noncompetitive because of annual capital recovery, license renewal also appeared as the means of survival. These two perceptions led to a third: License renewal should be sought immediately upon completion of the first 20 yr of operation. Although the basic engineering premise of license renewal remains sound, the perceptions regarding timing of an application may be incorrect. This paper suggests that a gauntlet of uncertainty exists for all plants. Further, it is most severe between the 20th and 30th years of operation. Thus, the competitive viability of the plant must be sustained for most of the initial term before license renewal can become a serious option

9 CFR 102.4 - U.S. Veterinary Biologics Establishment License.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biologics... LICENSES FOR BIOLOGICAL PRODUCTS § 102.4 U.S. Veterinary Biologics Establishment License. (a) Before a U.S. Veterinary Biologics Establishment License will be issued by the Administrator for any establishment, an...

Operating reactors licensing actions summary. Volume 5, Number 1

International Nuclear Information System (INIS)

1985-03-01

This document is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Resource Management. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program

Economic implications of nuclear plant license renewal in the U.S

International Nuclear Information System (INIS)

Smith, L.J.

2001-01-01

The NRC and the nuclear industry struggled for many years with the development of a viable license renewal rule. Now that a workable rule appears to have been developed, and the first license renewal applicants have received renewed licenses, the floodgates have opened and a large number of nuclear utilities have announced intentions to seek renewed NRC operating licenses. In this time when profound changes are being experienced in the electric generation markets in the United States, nuclear plant license renewal can have several economic effects that should be considered by utilities prior to the pursuit of an NRC license renewal. This paper examines some of the factors that may be affected by the prospect of an additional 20-year operating life of a nuclear plant. (author)

Allegheny County Dog Licenses

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — A list of dog license dates, dog breeds, and dog name by zip code. Currently this dataset does not include City of Pittsburgh dogs.

Appendix I. The commons deeds of the licenses (release 3.0, unported version)

OpenAIRE

2014-01-01

taken from http://creativecommons.org/licenses/by/3.0 taken from http://creativecommons.org/licenses/by-sa/3.0 taken from http://creativecommons.org/licenses/by-nd/3.0 taken from http://creativecommons.org/licenses/by-nc/3.0 taken from http://creativecommons.org/licenses/by-nc-sa/3.0 taken from http://creativecommons.org/licenses/by-nc-nd/3.0

Licensing Strategies of the Entreprising - But Vulnerable - `Intellectual property' Vendors

DEFF Research Database (Denmark)

Davis, Lee N.

This paper investigates in an exploratory manner the licensing strategies pursued by firms whose business model is based on developing and licensing out their intellectual property rights (IPRs). These are not traditional suppliers, since they do not engage in production or commercialization...... be differentiated along two main dimensions: whether the driving force behind the inventive process is "technology push" or "market pull", and the degree to which the innovative activities carried out by the IP vendor are mutually dependent upon the innovative activities of the other relevant market players....... On this basis, four main licensing strategies are identified. We investigate the relative benefits and costs of these four strategies, and the factors affecting licensing choices.Key words: Intellectual property, licensing, strategyJEL Codes: O31, OO34...

Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2

Directory of Open Access Journals (Sweden)

Karl-Uwe Reusswig

2016-10-01

Full Text Available Temporal separation of DNA replication initiation into licensing and firing phases ensures the precise duplication of the genome during each cell cycle. Cyclin-dependent kinase (CDK is known to generate this separation by activating firing factors and at the same time inhibiting licensing factors but may not be sufficient to ensure robust separation at transitions between both phases. Here, we show that a temporal gap separates the inactivation of firing factors from the re-activation of licensing factors during mitosis in budding yeast. We find that gap size critically depends on phosphorylation-dependent degradation of the firing factor Sld2 mediated by CDK, DDK, Mck1, and Cdc5 kinases and the ubiquitin-ligases Dma1/2. Stable mutants of Sld2 minimize the gap and cause increased genome instability in an origin-dependent manner when combined with deregulation of other replication regulators or checkpoint mechanisms. Robust separation of licensing and firing phases therefore appears indispensable to safeguard genome stability.

Recidivism Among Licensed-Released Prisoners Who Participated in the EM Program in Israel.

Science.gov (United States)

Shoham, Efrat; Yehosha-Stern, Shirley; Efodi, Rotem

2015-08-01

Toward the end of 2006, a pilot program was launched in Israel wherein licensed-released prisoners were put under electronic monitoring (EM). In addition to EM, the pilot program, operated by the Prisoners' Rehabilitation Authority, provides programs of occupational supervision and personal therapy and is designed to allow for early release of those prisoners who, without increased supervision, would have been found unsuitable for early release. The aim of this study was to ascertain whether participation in the EM program among licensed-released prisoners in Israel might bring about lessened recidivism. For that matter, rates of arrests and incarceration were examined during a follow-up period of up to 4 years, among the entirety of licensed-released prisoners participating in the EM program between the years 2007 and 2009 (n = 155). To compare recidivism rates, a control group was assembled from among the entirety of released prisoners who were found unsuitable for early release in judicial conditions, and had therefore served the full term of their incarceration, to be released between the years 2005 and 2006 (a period of time during which an EM program was not yet operated among licensed-released prisoners in Israel). Study findings clearly show that while among the control group, 42% of released prisoners were re-incarcerated, at the end of a 4-year follow-up period, only 15% among the study group had returned to prison. These findings can be explained by combining the Social Control theory and the Self-Control theory which consider the period of time under EM program and the occupational and familial integration tools for reducing criminal connections and enhancing pro-social behavior. © The Author(s) 2014.

Licensing the California low-level radioactive waste disposal facility

International Nuclear Information System (INIS)

Dressen, A.L.; Serie, P.J.; Junkert, R.

1992-01-01

California has made significant progress toward the issuance of a license to construct and operate the Southwestern Compact's low-level radioactive waste disposal facility. However, obstacles to completing construction and preparing to receive waste still exist. This paper will describe the technical licensing issues, EIR/S process, political events, and public interactions that have impacted on California regulators' ability to complete the license application review and reach a decision on issuing a license. Issues associated with safely and liability evaluations, finalization of the environmental impact report, and land transfer processes involving multiple state, federal, and local agencies will be identified. Major issues upon which public and political opposition is focusing will also be described. (author)

77 FR 20398 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2012-04-04

...), Svi Soudai, Manager, Application Type: New OFF License. Armada USA, LLC dba Armada Logistics (NVO... Logistics (NVO & OFF), 435 Division Street, Elizabeth, NJ 07076, Officer: Carlos E. Feliu, President.../Treasurer, (Qualifying Individual), Application Type: New NVO License. HYC Logistics, Inc. (NVO & OFF), 2600...

76 FR 10594 - Ocean Transportation Intermediary License Revocation

Science.gov (United States)

2011-02-25

... 515, effective on the corresponding date shown below: License Number: 2739NF. Name: Alison Transport... to maintain valid bonds. License Number: 2763F. Name: Logistics & Transportation Services Inc... Mohawk Global Logistics (ROC). Address: 52 Marway Circle, Suite 1, Rochester, NY 14624. Date Revoked...

21 CFR 310.4 - Biologics; products subject to license control.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Biologics; products subject to license control... to license control. (a) If a drug has an approved license under section 351 of the Public Health.... (b) To obtain marketing approval for radioactive biological products for human use, as defined in...

78 FR 56229 - Ocean Transportation Intermediary License Revocations and Terminations

Science.gov (United States)

2013-09-12

.... 40101) effective on the date shown. License No.: 004306N. Name: International Transport Services, Inc.... License No.: 020272NF. Name: CCT Corporation dba CCT Marine dba CCT Global Logistics. Address: 11250 NW... maintain valid bonds. License No.: 024023F. Name: OES Logistics, Inc Address: 10900 E. 183rd Street, 130...

The Case against a Smoker's License

OpenAIRE

Chapman, Simon

2012-01-01

BACKGROUND TO THE DEBATE: Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers desig...

The Case against a Smoker's License

OpenAIRE

Collin, J.

2012-01-01

Background to the debate: Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers desig...

Whom to Choose as License Partner?

DEFF Research Database (Denmark)

Laursen, Keld; Reichstein, Toke; Trombini, Giulia

2013-01-01

benefits and obviate issues related to technology transfer and knowledge recombination. At the same time, firms wish to select a partner operating in a different product market to minimize competitive downside issues and to access other product markets, skills and resources. We contend interdependence...... between technology and market forces: if partners are market distant, the likelihood of technology license contractual partnership decreases with partners’ technological distance. Using data on the formation of license partnerships in the global biopharmaceutical industry over the period 1994...

Personality traits of Turkish handgun license applicants.

Science.gov (United States)

Selek, Salih; Can, Serdar S; Yabanoglu, Ihsan

2012-10-01

Several theories have sought to explain the motivations for handgun possession and the relationship with personality. Perception of handguns also has cultural variations. The aim of the study is to evaluate handgun license applicants' personality profiles. 109 handgun license applicants were included in the study. Temperament and Character Inventory (TCI) scores of the applicants were recorded. Scores were compared with Turkish and American normative data for the Inventory. The study group had significantly lower subscores on novelty seeking, harm avoidance, and higher subscores on reward dependence and persistence compared to Turkish norms and significantly lower subscores on novelty seeking, reward dependence, and self-directedness compared to American norms. Results indicate that Turkish handgun license applicants' personality features are more similar to American norms.

License - Taxonomy Icon | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Taxonomy Icon License License to Use This Database Last updated : 2013/3/21 You may use this database...the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attribut...ion 2.1 Japan . If you use data from this database, please be sure attribute this database as follows: Taxon...ative Commons Attribution 2.1 Japan is found here . With regard to this database,

License - RGP gmap98 | LSDB Archive [Life Science Database Archive metadata

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Full Text Available List Contact us RGP gmap98 License License to Use This Database Last updated : 2015/02/12 You may use this database...e license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attributio...n-Share Alike 2.1 Japan . If you use data from this database, please be sure attribute this database as foll...on-Share Alike 2.1 Japan is found here . With regard to this database, you are licensed to: freely access part or whole of this datab

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Full Text Available List Contact us ChIP-Atlas License License to Use This Database Last updated : 2016/06/24 You may use this database...e license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attributio...n-Share Alike 4.0 International . If you use data from this database, please be sure attribute this database...national is found here . With regard to this database, you are licensed to: freely access part or whole of this database

LICENSE PLATE LOCALIZATION USING GABOR FILTERS AND NEURAL NETWORKS

OpenAIRE

Sami Ktata; Faouzi Benzarti; Hamid Amiri

2013-01-01

Vehicle License Plate Detection (LPD) is an important step for the vehicle plate recognition which can be used in the intelligent transport systems. Many methods have been proposed for the detection of license plates based on: Mathematical morphology, Discrete Wavelet Transform, Hough Transform and others. In general, an LPR system includes four main parts: Vehicle image acquisition, license plate detection, character segmentation and character recognition. In this study, we present a robust ...

76 FR 44330 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2011-07-25

.... Nguyen, Secretary/CFO, Application Type: New NVO & OFF License. Atlas Logistics LLC (NVO & OFF), 2801 NW...), Application Type: New NVO & OFF License. Bulk Cargo Services & Logistics Inc. (OFF), 15400 N.E. 103rd Drive..., Member/Chief Executive Manager, (Qualifying Individual), Stina Storr, Member/ Managing Member...

77 FR 18815 - Ocean Transportation Intermediary License; Applicants

Science.gov (United States)

2012-03-28

... NVO License. American Patriot Lines, Inc. dba Tier One Logistics (NVO), 8616 La Tijera Boulevard, 401..., AL 36608. Officer: Samford T. Myers, Manager (Qualifying Individual). Application Type: New NVO & OFF License. Bluesea Logistics Corporation (NVO), 327 Elizabeth Avenue, Apt. A, Monterey Park, CA 91755-2044...

25 CFR 141.9 - Application for license renewal.

Science.gov (United States)

2010-04-01

... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES BUSINESS PRACTICES ON... the applicant has made as a reservation business owner and the applicant's present fitness to reside... pending consideration of application for license renewal. (c) Prior to expiration of the existing license...

The licensing procedure under Atomic Energy Law

International Nuclear Information System (INIS)

Ronellenfitsch, M.

1983-01-01

This post-doctoral thesis of 1981 has been updated to include developments in this field up to the year 1983. The author discusses in detail all questions relating to the peaceful uses of nuclear energy in the Federal Republic of Germany, predominantly from the point of view of administrative law. He investigates nuclear energy and its contribution to electricity supplies with a view to other energy sources, renewable energy sources, alternative energy policies, nuclear fuel and the fuel cycle, development of the nuclear industry, nuclear power stations in operation, under construction, or in development. Following a survey of the nuclear controversy, both on the national and the international level, the author reviews the legal system and arising controversies in the Federal Republic of Germany, defining the purpose of this thesis to be the systematic analysis of the available legal instruments, in order to show structural deficiencies in the planning law relating to nuclear power stations, and thus reasons of ambiguities within the licensing procedure. The author studies the following terms and requirements: licensing requirements and licensability, the licensing method and scenario, the legal character of licences, their contents and effects within the stepwise procedure, and due publication. (HSCH) [de

Image simulation for automatic license plate recognition

Science.gov (United States)

Bala, Raja; Zhao, Yonghui; Burry, Aaron; Kozitsky, Vladimir; Fillion, Claude; Saunders, Craig; Rodríguez-Serrano, José

2012-01-01

Automatic license plate recognition (ALPR) is an important capability for traffic surveillance applications, including toll monitoring and detection of different types of traffic violations. ALPR is a multi-stage process comprising plate localization, character segmentation, optical character recognition (OCR), and identification of originating jurisdiction (i.e. state or province). Training of an ALPR system for a new jurisdiction typically involves gathering vast amounts of license plate images and associated ground truth data, followed by iterative tuning and optimization of the ALPR algorithms. The substantial time and effort required to train and optimize the ALPR system can result in excessive operational cost and overhead. In this paper we propose a framework to create an artificial set of license plate images for accelerated training and optimization of ALPR algorithms. The framework comprises two steps: the synthesis of license plate images according to the design and layout for a jurisdiction of interest; and the modeling of imaging transformations and distortions typically encountered in the image capture process. Distortion parameters are estimated by measurements of real plate images. The simulation methodology is successfully demonstrated for training of OCR.

Licensing and accident reviews for an HNEC

International Nuclear Information System (INIS)

Clark, R.G.

1978-09-01

The purpose of this review was to identify siting or other concerns that may indicate limitations on the ability to license a nuclear energy center at Hanford. Several studies on nuclear energy centers have been completed and some have included licensing (regulatory) aspects of siting nuclear power centers. This review however, was primarily to identify any limitations that may affect licensing specifically at an HNEC. The scope included examining existing criteria for siting nuclear facilities, including single reactor and multireactor (multi-unit) sites. To fill a void in other analyses and to gain some perspective on another impact of an HNEC, the scope was extended to analyze the consequences within the HNEC, of a class nine accident at a unit at one site. A predictive model utilized in this analysis was developed from meteorological parameters based on thirty years of meteorological records at Hanford. From this analysis, additional perspective was developed on the relative severity of the effects of rare events, both man made and from unstable conditions in nature, on the operation of (and the ability to license) an energy center at Hanford

License - PSCDB | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

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License - DMPD | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...ownload License Update History of This Database Site Policy | Contact Us License - DMPD | LSDB Archive ...

Two Approaches to Reactor Decommissioning: 10 CFR Part 50 License Termination and License Amendment, Lessons Learned from the Regulatory Perspective

International Nuclear Information System (INIS)

Watson, B.A.; Buckley, J.T.; Craig, C.M.

2006-01-01

Trojan Nuclear Plant (Trojan) and Maine Yankee Nuclear Plant (Maine Yankee) were the first two power reactors to complete decommissioning under the U. S. Nuclear Regulatory Commission's (NRC's) License Termination Rule (LTR), 10 CFR Part 20, Subpart E. The respective owners' decisions to decommission the sites resulted in different approaches to both the physical aspects of the decommissioning, and the approach for obtaining approval for completing the decommissioning in accordance with regulations. Being in different States, the two single-unit pressurized water reactor sites had different State requirements and levels of public interest that impacted the decommissioning approaches. This resulted in significant differences in decommissioning planning, conduct of decommissioning operations, volumes of low- level radioactive waste disposed, and the final status survey (FSS) program. While both licensees have Independent Spent Fuel Storage Installations (ISFSIs), Trojan obtained a separate license for the ISFSI in accordance with the requirements of 10 CFR Part 72 and terminated their 10 CFR Part 50 license. Maine Yankee elected to obtain a general license under 10 CFR Part 50 for the ISFSI and reduce the physical site footprint to the ISFSI through a series of license amendments. While the NRC regulations are flexible and allow different approaches to ISFSI licensing there are separate licensing requirements that must be addressed. In 10 CFR 50.82, the NRC mandates public participation in the decommissioning process. For Maine Yankee, public input resulted in the licensee entering into an agreement with a concerned citizen group and resulted in State legislation that significantly lowered the dose limit below the NRC radiological criteria of 25 mrem (0.25 mSv) per year (yr) in 10 CFR 20.1402 for unrestricted use. The lowering of the radiological criteria resulted in a significant dose modeling effort using site-specific Derived Concentrations Guideline Levels (DCGLs

77 FR 24712 - Ocean Transportation Intermediary License; Applicants

Science.gov (United States)

2012-04-25

... Global Logistics LLC (OFF), 9816 Whithorn Drive, Suite B, Houston, TX 77095, Officer: Herbert R. Hogg, Operating Manager (Qualifying Individual), Application Type: New OFF License. Toyo Logistics America, Inc... Individual), Application Type: New NVO License. Choiceone Logistics, Inc. (NVO & OFF), 10025 NW 116th Way, 17...

75 FR 69080 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2010-11-10

... license as a Non-Vessel-Operating Common Carrier (NVO), and/or Ocean Freight Forwarder (OFF)--Ocean..., Building 14-A, Kenner, LA 70062, Officers: Gary J. Cheramie, President (Qualifying Individual), George...: License Transfer. Total Global Solutions, Inc. (NVO & OFF), 4290 Bells Ferry Road 224, Suite 106, Kennesaw...

75 FR 61757 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2010-10-06

...), Jinho Um, CFO. Application Type: New NVO & OFF License. Junction Int'l Logistics, Inc. (NVO), 17870 Castleton Street, Suite 107, City of Industry, CA 91748. Officers: Charles Kuo, Secretary (Qualifying.... Application Type: New NVO & OFF License. Red Arrow Consulting, Inc. dba Red Arrow Logistics (OFF), 14925 SE...

78 FR 6325 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2013-01-30

.... Application Type: New NVO & OFF License. Naca Logistics (USA), Inc. dba Brennan International Transport, dba...). Application Type: New NVO & OFF License. Miami Freight & Logistics Services, Inc. (NVO & OFF), 3630 NW 76th... World Shipping, dba OWS, dba Ocean Express, dba Oceanexpress Vanguard Logistics Services, dba Vanguard...

NRC Licensing Status Summary Report for NGNP

Energy Technology Data Exchange (ETDEWEB)

Moe, Wayne Leland [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinsey, James Carl [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2014-11-01

The Next Generation Nuclear Plant (NGNP) Project, initiated at Idaho National Laboratory (INL) by the U.S. Department of Energy (DOE) pursuant to provisions of the Energy Policy Act of 2005, is based on research and development activities supported by the Department of Energy Generation IV Nuclear Energy Systems Initiative. The principal objective of the NGNP Project is to support commercialization of high temperature gas-cooled reactor (HTGR) technology. The HTGR is a helium-cooled and graphite moderated reactor that can operate at temperatures much higher than those of conventional light water reactor (LWR) technologies. The NGNP will be licensed for construction and operation by the Nuclear Regulatory Commission (NRC). However, not all elements of current regulations (and their related implementation guidance) can be applied to HTGR technology at this time. Certain policies established during past LWR licensing actions must be realigned to properly accommodate advanced HTGR technology. A strategy for licensing HTGR technology was developed and executed through the cooperative effort of DOE and the NRC through the NGNP Project. The purpose of this report is to provide a snapshot of the current status of the still evolving pre-license application regulatory framework relative to commercial HTGR technology deployment in the U.S. The following discussion focuses on (1) describing what has been accomplished by the NGNP Project up to the time of this report, and (2) providing observations and recommendations concerning actions that remain to be accomplished to enable the safe and timely licensing of a commercial HTGR facility in the U.S.

Public licenses and public domain as alternatives to copyright

OpenAIRE

Köppel, Petr

2012-01-01

The work first introduces the area of public licenses as a space between the copyright law and public domain. After that, consecutively for proprietary software, free and open source software, open hardware and open content, it maps particular types of public licenses and the accompanying social and cultural movements, puts them in mutual as well as historical context, examines their characteristics and compares them to each other, shows how the public licenses are defined by various accompan...

Workplace Violence and Job Outcomes of Newly Licensed Nurses

OpenAIRE

Chang, Hyoung Eun; Cho, Sung-Hyun

2016-01-01

Purpose: The purpose of this study was to examine the prevalence of workplace violence toward newly licensed nurses and the relationship between workplace violence and job outcomes. Methods: An online survey was conducted of newly licensed registered nurses who had obtained their license in 2012 or 2013 in South Korea and had been working for 5–12 months after first being employed. The sample consisted of 312 nurses working in hospitals or clinics. The Copenhagen Psychosocial Questionnaire...

Operating reactors licensing actions summary. Vol.4, No. 4

International Nuclear Information System (INIS)

1984-06-01

The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors

Advanced CANDU reactor pre-licensing progress

International Nuclear Information System (INIS)

Popov, N.K.; West, J.; Snell, V.G.; Ion, R.; Archinoff, G.; Xu, C.

2005-01-01

The Advanced CANDU Reactor (ACR) is an evolutionary advancement of the current CANDU 6 reactor, aimed at producing electrical power for a capital cost and at a unit-energy cost significantly less than that of the current reactor designs. The Canadian Nuclear Safety Commission (CNSC) staff are currently reviewing the ACR design to determine whether, in their opinion, there are any fundamental barriers that would prevent the licensing of the design in Canada. This CNSC licensability review will not constitute a licence, but is expected to reduce regulatory risk. The CNSC pre-licensing review started in September 2003, and was focused on identifying topics and issues for ACR-700 that will require a more detailed review. CNSC staff reviewed about 120 reports, and issued to AECL 65 packages of questions and comments. Currently CNSC staff is reviewing AECL responses to all packages of comments. AECL has recently refocused the design efforts to the ACR-1000, which is a larger version of the ACR design. During the remainder of the pre-licensing review, the CNSC review will be focused on the ACR-1000. AECL Technologies Inc. (AECLT), a wholly-owned US subsidiary of AECL, is engaged in a pre-application process for the ACR-700 with the US Nuclear Regulatory Commission (USNRC) to identify and resolve major issues prior to entering a formal process to obtain standard design certification. To date, the USNRC has produced a Pre-Application Safety Assessment Report (PASAR), which contains their reviews of key focus topics. During the remainder of the pre-application phase, AECLT will address the issues identified in the PASAR. Pursuant to the bilateral agreement between AECL and the Chinese nuclear regulator, the National Nuclear Safety Administration (NNSA) and its Nuclear Safety Center (NSC), NNSA/NSC are reviewing the ACR in seven focus areas. The review started in September 2004, and will take three years. The main objective of the review is to determine how the ACR complies

License - TMBETA-GENOME | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us TMBETA-GENOME License License to Use This Database Last updated : 2015/03/09 You may use this database... the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attribu...tion-Share Alike 2.1 Japan . If you use data from this database, please be sure attribute this database as f....1 Japan . The summary of the Creative Commons Attribution-Share Alike 2.1 Japan is found here . With regard to this database

License - KAIKOcDNA | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us KAIKOcDNA License License to Use This Database Last updated : 2014/10/08 You may use this database... license terms regarding the use of this database and the requirements you must follow in using this database...-Share Alike 2.1 Japan . If you use data from this database, please be sure attribute this database as follo...e Alike 2.1 Japan is found here . With regard to this database, you are licensed to: freely access part or whole of this database..., and acquire data; freely redistribute part or whole of the data from this database; a

License - RGP caps | LSDB Archive [Life Science Database Archive metadata

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License - DB-SPIRE | LSDB Archive [Life Science Database Archive metadata