Liver disease associated with intestinal failure in the small bowel syndrome Doença hepática associada à falência intestinal na síndrome do intestino curto

Directory of Open Access Journals (Sweden)

Rafael Kemp

2006-01-01

Full Text Available The introduction of the Total Parenteral Nutrition (TPN has given rise to a new hope in the treatment of intestinal failure (LF associated with the Short Bowel Syndrome (SBS. However, together with the TPN and the increase of survival of these patients, new problems and questions have emerged, as well as new therapeutical procedures. Taking into consideration this emerging reality, this paper has the purpose to undertake a review of current concepts and available treatments for patients with IF associated-liver disease. Although TPN provides an increase of survival of patients with intestinal failure, it is a potential source of complication such as: septicemia, hyperglycemia, venous thrombosis and liver disease. There are several hypothesis conceived to explain the liver disease associated to intestinal failure, however the only definite treatment as a potential to reverse the non-cirrhotic liver disease is the small intestine transplantation. Despite indications for intestine transplantation are not entirely defined in literature, the trend is its early indication in high-risk patients, preserving the liver integrity and preventing the eventual need of both liver and intestine transplantations altogether.A introdução da Nutrição Parenteral Total (NPT despertou uma nova esperança para o tratamento da falência intestina (FI associada a Síndrome do Intestino Curto (SIC. No entanto, junto com a NPT e o aumento da sobrevida destes pacientes, novos problemas e perguntas emergiram, assim como novas terapêuticas. Tendo em vista esta realidade emergente, o intuito deste artigo é realizar uma revisão dos conceitos atuais e dos tratamentos disponíveis para pacientes com doença hepática associada a FI. A NPT apesar de proporcionar aumento da sobrevida nos pacientes com falência intestinal é fonte potencial de complicações, como: septicemia, hiperglicemia, trombose venosa e doença hepática. Diversas são as hipóteses aventadas para

Falência ovariana precoce associada a deleção no braço longo do cromossomo: relato de dois casos e revisão da literatura Premature ovarian failure with a deletion in the long arm of chromosome: report of two cases and review of the literature

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Mariangela Badalotti

2006-09-01

Full Text Available Falência ovariana prematura pode ser idiopática ou estar associada a várias distúrbios auto-imunes ou genéticos, como as deleções do cromossomo X. Relatamos dois novos casos de deleções do braço longo do cromossomo X, em pacientes nuligrávidas apresentando amenorréia secundária e infertilidade. Nenhuma paciente referia história familiar de falência ovariana prematura e relatavam desenvolvimento puberal normal. A avaliação genética mostrou deleção distal no braço longo do cromossomo X, sendo os resultados 46,X,del(Xq22 e 46,X,del(Xq13q28, respectivamente. Após o diagnóstico as pacientes optaram por fertilização in vitro com óvulos doados.Premature ovarian failure may be idiopathic or associated with several autoimmune and genetic disorders as X chromosome deletions. We report two cases of preamture ovarian failure associated with a deletion in the long arm of X chromosome. Both patients were nulligravidas presenting secondary amenorrhea and complaints of infertility, without family history of premature ovarian failure and reporting normal puberal development. Their karyotypes showed deletions of the distal long arm of all X chromosomes and were 46,X, del(Xq22 and 46,X, del(Xq13q28, respectively. After the diagnosis the patients decided to be submitted to an in vitro fertilization with egg donation.

EL MAESTRO ORLANDO FALS BORDA SUS IDEAS EDUCATIVAS Y SOCIALES PARA EL CAMBIO EN LA SOCIEDAD COLOMBIANA

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Javier Ocampo López

2009-01-01

Full Text Available Este trabajo de investigación de HISULA en la serie de Educadores Latinoamericanos tiene por objeto el estudio de las ideas educativas y la metodología científica de la Investigación-Acción Participativa del educador Dr. Orlando Fals Borda, uno de los grandes ideólogos de la educación universitaria en Colombia. Se preocupa por el análisis de sus principales obras relacionadas con el estudio sociológico de los campesinos de los Andes y el Hombre y la Tierra en la región cundiboyacense del Altiplano Andino. Este ilustre educador barranquillero hizo sus trabajos de investigación sociológica del pueblo colombiano y defendió el papel de la educación en el cambio social. Con su metodología de la investigación-acción participativa señaló los nuevos rumbos de la educación colombiana centrada en el alumno y en la filosofía del "aprender haciendo". En sus actividades docentes formó una generación de sociólogos dedicados a la investigación social en una época de crisis y de cambios. Por ello su acción se realizó en la Facultad de Sociología de la Universidad Nacional y en sus investigaciones científicas y educativas, destacando su metodología de "La investigación-Acción Participativa". Su actuación fue definitiva como ideólogo de la Constitución Nacional de 1991, en la cual se plasmaron algunas de sus ideas.

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis.

LENUS (Irish Health Repository)

Byrne, Susan

2010-11-03

Background The population rate of familial amyotrophic lateral sclerosis (FALS) is frequently reported as 10%. However, a systematic review and meta-analysis of the true population based frequency of FALS has never been performed. Method A Medline literature review identified all original articles reporting a rate of FALS. Studies were grouped according to the type of data presented and examined for sources of case ascertainment. A systematic review and meta-analysis of reported rates of FALS was then conducted to facilitate comparison between studies and calculate a pooled rate of FALS. Results 38 papers reported a rate of FALS. Thirty-three papers were included in analysis and the rate of FALS for all studies was 4.6% (95% CI 3.9% to 5.5%). Restricting the analysis to prospective population based registry data revealed a rate of 5.1% (95% CI 4.1% to 6.1%). The incidence of FALS was lower in southern Europe. There was no correlation between rate of FALS and reported SOD1 mutation rates. Conclusion The rate of FALS among prospective population based registries is 5.1% (CI 4.1 to 6.1%), and not 10% as is often stated. Further detailed prospective population based studies of familial ALS are required to confirm this rate.

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis.

LENUS (Irish Health Repository)

Byrne, Susan

2012-02-01

BACKGROUND: The population rate of familial amyotrophic lateral sclerosis (FALS) is frequently reported as 10%. However, a systematic review and meta-analysis of the true population based frequency of FALS has never been performed. METHOD: A Medline literature review identified all original articles reporting a rate of FALS. Studies were grouped according to the type of data presented and examined for sources of case ascertainment. A systematic review and meta-analysis of reported rates of FALS was then conducted to facilitate comparison between studies and calculate a pooled rate of FALS. RESULTS: 38 papers reported a rate of FALS. Thirty-three papers were included in analysis and the rate of FALS for all studies was 4.6% (95% CI 3.9% to 5.5%). Restricting the analysis to prospective population based registry data revealed a rate of 5.1% (95% CI 4.1% to 6.1%). The incidence of FALS was lower in southern Europe. There was no correlation between rate of FALS and reported SOD1 mutation rates. CONCLUSION: The rate of FALS among prospective population based registries is 5.1% (CI 4.1 to 6.1%), and not 10% as is often stated. Further detailed prospective population based studies of familial ALS are required to confirm this rate.

The effects of cultivar and harvest year on the fatty alcohol composition of olive oils from Southwest Calabria (Italy

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Giuffrè, A. M.

2014-03-01

Full Text Available The fatty alcohol (FAL composition of olive oils produced in Southwest Calabria (Southern Italy was analyzed over three harvest years 2005–2006–2007. Three autochthonous cultivars: Cassanese, Ottobratica, Sinopolese and seven allochtonous cultivars: Coratina, Itrana, Leccino, Nocellara Messinese, Nociara, Pendolino and Picholine were considered. Hexacosanol was always the main FAL occurring in the olive oil. The autochthonous cultivars were among those with the highest total FAL contents. Nevertheless, both autochthonous and allochthonous cultivars produced olive oil within the limit indicated by EU and IOC regulations. Cultivar affected the FAL content highly significantly or very highly significantly, whereas in a large part of the cases the harvest year did not influence the FAL content. Cultivar x harvest year influenced highly significantly or very highly significantly only C22-OH, C23-OH, C24-OH, C25-OH, odd chain FALs and the ratio even chain/odd chain FALs.Se ha analizado, durante tres cosechas 2005–2006–2007, la composición de alcoholes grasos (FAL de aceites de oliva producidos en el suroeste de Calabria (sur de Italia. Se consideraron tres cultivares autóctonos: Cassanese, Ottobratica y Sinopolese y siete alóctonas: Coratina, Itrana, Leccino, Nocellara Messinese, Nociara, Pendolino y Picholine. Hexacosanol fue siempre el principal FAL en los aceites de oliva. Los cultivares autóctonos se encuentran entre los de mayor contenido total de FAL. No obstante, ambos cultivares, autóctonos y alóctonos producen aceites de oliva dentro de los límites de los reglamentos de la UE y del COI. Los cultivares afectan de manera altamente significativa o muy significativa al contenido de FAL, mientras que el año de cosecha no influyó en el contenido de FAL. Cultivar x año de cosecha influye de manera altamente significativa o muy significativa sobre C22-OH, C23-OH, C24-OH, C25-OH, al total de alcoholes grasos de cadena impar y a la

[An early history of Japanese amyotrophic lateral sclerosis (ALS)-related diseases and the current development].

Science.gov (United States)

Abe, Koji

2018-03-28

The present review focuses an early history of Japanese amyotrophic lateral sclerosis (ALS)-related diseases and the current development. In relation to foreign previous reports, five topics are introduced and discussed on ALS with dementia, ALS/Parkinsonism dementia complex (ALS/PDC), familial ALS (FALS), spinal bulbar muscular atrophy (SBMA), and multisystem involvement especially in cerebellar system of ALS including ALS/SCA (spinocerebellar ataxia) crossroad mutation Asidan. This review found the great contribution of Japanese reports on the above five topics, and confirmed the great development of ALS-related diseases over the past 120 years.

Genetic analysis of patients with familial and sporadic amyotrophic lateral sclerosis in a Brazilian Research Center.

Science.gov (United States)

Chadi, Gerson; Maximino, Jessica Ruivo; Jorge, Frederico Mennucci de Haidar; Borba, Fabrício Castro de; Gilio, Joyce Meire; Callegaro, Dagoberto; Lopes, Camila Galvão; Santos, Samantha Nakamura Dos; Rebelo, Gabriela Natania Sales

2017-05-01

To investigate gene mutations in familial form (FALS) and sporadic form (SALS) of amyotrophic lateral sclerosis (ALS) in a highly miscegenated population. Frequencies of mutations in the C9orfF72, TARDBP, SOD1, FUS and VAPB genes were investigated in a cohort of FALS (n = 39) and SALS (n = 189) subjects from the Research Centre of the University of São Paulo School of Medicine. All patients were subjected to C9orf72 and TARDBP analyses. SOD1, FUS and VAPB were also evaluated in FALS subjects. Mutations were identified in FALS (61.3%) and SALS (5.3%) patients. Mutations in C9orf72 (12.8%, >45 GGGGCC hexanucleotide repeats), VAPB (43.6%, P56S) and SOD1 (7.7%, L145S) were identified in FALS subjects. Pathogenic C9orf72 expansions (2.64%) were identified in some SALS patients. Similar changes of TARDBP were found in SALS (2.64%) but not in FALS subjects. No FUS mutations were seen in any FALS subjects. TARDBP and C9orf72 mutations in this cohort were similar to those found in other centres worldwide. VAPB mutation (P56S) was highly prevalent in Brazilian FALS patients.

Effects of 1000 C oxide surfaces on room temperature aqueous corrosion and environmental embrittlement of iron aluminides

Energy Technology Data Exchange (ETDEWEB)

Buchanan, R.A.; Perrin, R.L. [Univ. of Tennessee, Knoxville, TN (United States). Dept. of Materials Science and Engineering

1997-12-01

Results of electrochemical aqueous-corrosion studies at room temperature indicate that retained in-service-type high-temperature surface oxides (1000 C in air for 24 hours) on FA-129, FAL and FAL-Mo iron aluminides cause major reductions in pitting corrosion resistance in a mild acid-chloride solution designed to simulate aggressive atmospheric corrosion. Removal of the oxides by mechanical grinding restores the corrosion resistance. In a more aggressive sodium tetrathionate solution, designed to simulate an aqueous environment contaminated by sulfur-bearing combustion products, only active corrosion occurs for both the 1000 C oxide and mechanically cleaned surfaces at FAL. Results of slow-strain-rate stress-corrosion-cracking tests on FA-129, FAL and FAL-Mo at free-corrosion and hydrogen-charging potentials in the mild acid chloride solution indicate somewhat higher ductilities (on the order of 50%) for the 1000 C oxides retard the penetration of hydrogen into the metal substrates and, consequently, are beneficial in terms of improving resistance to environmental embrittlement. In the aggressive sodium tetrathionate solution, no differences are observed in the ductilities produced by the 1000 C oxide and mechanically cleaned surfaces for FAL.

Photoacoustic Transformation at Oppositely Directed Interaction Electromagnetic Waves in the Magnetoactive Two-Layer Medium

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Mityurich G.S.

2013-12-01

Full Text Available Celem pracy sa badania nad foto-akustyczna generacja dzwieku w magnetoaktywnych układach dwuwarstwowych, w warunkach interferencji tunelowej fal elektromagnetycznych. Badano warunki całkowitego wytłumienia amplitudy sygnału fotoakustycznego w funkcji polaryzacji przeciwbieznych, oddziałujacych wzajemnie fal, ich faz poczatkowych oraz intensywnosci jednej z przeciwbieznych wiazek. Praca przedstawia efektywna metode sterowania termooptyczna generacja dzwieku w strukturach magnetoaktywnych, podczas tunelowej interferencji fal elektromagnetycznych.

Corrective Action Decision Document/Closure Report for Corrective Action Unit 561: Waste Disposal Areas, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Mark Krauss

2011-08-01

counterweights were also removed, and the soil below these items does not contain contamination that exceeds the FAL for lead. (4) The concrete-like material at CAS 25-08-02 contains arsenic above the FAL of 23 mg/kg. This concrete-like material was removed, and the soil that remains at this CAS does not contain contamination exceeding the FALs. Lead-acid batteries were also removed, and the soil below the batteries does not contain contamination that exceeds the FAL for lead. (5) The surface soils within the main waste dump at the posted southern radioactive material area (RMA) at CAS 25-23-21 contain cesium (Cs)-137 and PCBs above the FALs of 72.9 picocuries per gram (pCi/g) and 0.74 mg/kg, respectively. The soil was removed from the RMA, and the soil that remains at this CAS does not contain contamination exceeding the FALs. (6) The surface and subsurface soils at CAS 25-25-19 do not contain contamination exceeding the FALs. In addition, lead bricks were removed, and the soil below these items does not contain contamination that exceeds the FAL for lead. The following best management practices were implemented: (1) Housekeeping debris at CASs 02-08-02, 23-21-04, 25-08-02, 25-23-21, and 25-25-19 was removed and disposed of; (2) The open trenches at CAS 23-21-04 were backfilled; (3) The waste piles at CAS 25-08-02 were removed and the area leveled to ground surface; and (4) The remaining waste piles at the main waste dump at CAS 25-23-21 were leveled to ground surface. Therefore, NNSA/NSO provides the following recommendations: (1) No further action for CASs 01-19-01, 03-19-02, 05-62-01, 12-23-09, and 22-19-06; (2) Closure in place with an FFACO use restriction (UR) at CAS 02-08-02 for the remaining PAH-, arsenic-, and lead-contaminated soil, and the melted lead PSM. The UR form and map have been filed in the NNSA/NSO Facility Information Management System, the FFACO database, and the NNSA/NSO CAU/CAS files; (3) No further corrective action at CAS 23-21-04, as the lead bricks

Corrective Action Decision Document/Closure Report for Corrective Action Unit 561: Waste Disposal Areas, Nevada National Security Site, Nevada, Revision 0

International Nuclear Information System (INIS)

Krauss, Mark

2011-01-01

counterweights were also removed, and the soil below these items does not contain contamination that exceeds the FAL for lead. (4) The concrete-like material at CAS 25-08-02 contains arsenic above the FAL of 23 mg/kg. This concrete-like material was removed, and the soil that remains at this CAS does not contain contamination exceeding the FALs. Lead-acid batteries were also removed, and the soil below the batteries does not contain contamination that exceeds the FAL for lead. (5) The surface soils within the main waste dump at the posted southern radioactive material area (RMA) at CAS 25-23-21 contain cesium (Cs)-137 and PCBs above the FALs of 72.9 picocuries per gram (pCi/g) and 0.74 mg/kg, respectively. The soil was removed from the RMA, and the soil that remains at this CAS does not contain contamination exceeding the FALs. (6) The surface and subsurface soils at CAS 25-25-19 do not contain contamination exceeding the FALs. In addition, lead bricks were removed, and the soil below these items does not contain contamination that exceeds the FAL for lead. The following best management practices were implemented: (1) Housekeeping debris at CASs 02-08-02, 23-21-04, 25-08-02, 25-23-21, and 25-25-19 was removed and disposed of; (2) The open trenches at CAS 23-21-04 were backfilled; (3) The waste piles at CAS 25-08-02 were removed and the area leveled to ground surface; and (4) The remaining waste piles at the main waste dump at CAS 25-23-21 were leveled to ground surface. Therefore, NNSA/NSO provides the following recommendations: (1) No further action for CASs 01-19-01, 03-19-02, 05-62-01, 12-23-09, and 22-19-06; (2) Closure in place with an FFACO use restriction (UR) at CAS 02-08-02 for the remaining PAH-, arsenic-, and lead-contaminated soil, and the melted lead PSM. The UR form and map have been filed in the NNSA/NSO Facility Information Management System, the FFACO database, and the NNSA/NSO CAU/CAS files; (3) No further corrective action at CAS 23-21-04, as the lead bricks

Corrective Action Decision Document/Closure Report for Corrective Action Unit 365: Baneberry Contamination Area, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Patrick Matthews

2011-09-01

Corrective Action Unit 365 comprises one corrective action site (CAS), CAS 08-23-02, U-8d Contamination Area. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 365 based on the implementation of the corrective action of closure in place with a use restriction (UR). Corrective action investigation (CAI) activities were performed from January 18, 2011, through August 2, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 365: Baneberry Contamination Area. The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 365 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in supporting the DQO decisions. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were found to be present to the southwest of the Baneberry crater. It was also assumed that radionuclide levels present within the crater and fissure exceed the FAL. Corrective actions were undertaken that consisted of establishing a UR and posting warning signs for the crater, fissure, and the area located to the southwest of the crater where soil concentrations exceeded the FAL. These URs were recorded in the FFACO database; the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Facility Information Management System; and the NNSA/NSO CAU/CAS files. Therefore, NNSA/NSO provides the following recommendations: (1) No further corrective actions beyond what are described in this document are necessary for CAU 365. (2) A Notice of Completion to

Valorization of lignite combustion residues and ferroalumina in the production of aggregates.

Science.gov (United States)

Anagnostopoulos, I M; Stivanakis, V E; Angelopoulos, G N; Papamantellos, D C

2010-02-15

The present research study investigates the synergy of industrial solid by-products from lignite combustion (fly ash and bottom ash) and aluminum production (ferroalumina) in the production of lightweight aggregates (LWA). The process consists of two stages, pelletization and sintering. Bottom ash (BA) is used as the principal raw material in mixtures while ferroalumina (FAL) is added in lower percentages (5-30 wt%). BA carbon content is used as the fuel of sintering process in high temperatures, around 1250 degrees C, and gas generation is responsible for porous structure formation. Physical properties such as porosity, water absorption and bulk density, of sintering products are measured. Increase of FAL percentage in sintering mixtures results in decrease of porosity from 61% to 35% and of water absorption from 61% to 21% and in increase of bulk density from 1.02 g/cm(3) to 1.80 g/cm(3) of the produced aggregates. Aggregates produced by FAL addition up to 20 wt% are characterized as LWA. Aggregates formed are used in the production of concrete specimens. Compressive strength of concrete increases by increasing FAL addition in aggregates from 5 wt% to 15 wt% (highest strength value), while decrease by increasing FAL addition from 20 wt% to 30 wt%. FAL addition in lignite ashes sintering mixtures (up to 15 wt%) is considered as an important parameter for enhancing aggregates strength.

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.

Science.gov (United States)

Deng, Han-Xiang; Zhai, Hong; Bigio, Eileen H; Yan, Jianhua; Fecto, Faisal; Ajroud, Kaouther; Mishra, Manjari; Ajroud-Driss, Senda; Heller, Scott; Sufit, Robert; Siddique, Nailah; Mugnaini, Enrico; Siddique, Teepu

2010-06-01

Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration. Most cases of ALS are sporadic (SALS), but about 5 to 10% of ALS cases are familial (FALS). Recent studies have shown that mutations in FUS are causal in approximately 4 to 5% of FALS and some apparent SALS cases. The pathogenic mechanism of the mutant FUS-mediated ALS and potential roles of FUS in non-FUS ALS remain to be investigated. Immunostaining was performed on postmortem spinal cords from 78 ALS cases, including SALS (n = 52), ALS with dementia (ALS/dementia, n = 10), and FALS (n = 16). In addition, postmortem brains or spinal cords from 22 cases with or without frontotemporal lobar degeneration were also studied. In total, 100 cases were studied. FUS-immunoreactive inclusions were observed in spinal anterior horn neurons in all SALS and FALS cases, except for those with SOD1 mutations. The FUS-containing inclusions were also immunoreactive with antibodies to TDP43, p62, and ubiquitin. A fraction of tested FUS antibodies recognized FUS inclusions, and specific antigen retrieval protocol appeared to be important for detection of the skein-like FUS inclusions. Although mutations in FUS account for only a small fraction of FALS and SALS, our data suggest that FUS protein may be a common component of the cellular inclusions in non-SOD1 ALS and some other neurodegenerative conditions, implying a shared pathogenic pathway underlying SALS, non-SOD1 FALS, ALS/dementia, and related disorders. Our data also indicate that SOD1-linked ALS may have a pathogenic pathway distinct from SALS and other types of FALS.

Pęknięcie nerki jako rzadkie powikłanie zabiegu ESWL (kruszenie kamieni falą generowaną pozaustrojowo

Directory of Open Access Journals (Sweden)

Tomasz Ząbkowski

2010-12-01

Full Text Available Kruszenie kamieni falą generowaną pozaustrojowo (extracorporeal shock wave lithotripsy, ESWL należy do podstawowych metod leczenia kamicy nerkowej – zyskała ona szerokie zastosowanie jako metoda małoinwazyjna i skuteczna. Wraz ze wzrostem doświadczenia urologów wykonujących zabiegi litotrypsji oraz udoskonalaniem litotryptorów wzrasta skuteczność wykonywanych zabiegów. Autorzy przedstawiają niezmiernie rzadkie powikłanie po zabiegu ESWL pod postacią pęknięcia nerki i masywnego krwawienia do przestrzeni zaotrzewnowej. Siedemdziesięcioośmioletni pacjent z małopłytkowością, po zabiegu by-passów (coronary artery bypass graft, CABG, po implantacji układu stymulującego serca, z nadciśnieniem tętniczym i cukrzycą typu II, leczony doustnymi antykoagulantami został przyjęty do Kliniki Urologicznej 6 godzin po zabiegu ESWL w trybie pilnym z powodu pogarszającego się stanu ogólnego, narastających dolegliwości bólowych w lewej okolicy lędźwiowej i masywnego krwiomoczu. Po przeprowadzeniu badania podmiotowego, przedmiotowego i na podstawie wykonanych badań dodatkowych (tomografia komputerowa jamy brzusznej rozpoznano pęknięcie nerki z masywnym krwiakiem przestrzeni zaotrzewnowej. Chorego zakwalifikowano w trybie pilnym do leczenia operacyjnego. Śródoperacyjnie stwierdzono ogromny krwiak wypełniający przestrzeń zaotrzewnową wokół nerki lewej i schodzący do lewego dołu biodrowego oraz masywne krwawienie z całej powierzchni uszkodzonej nerki bez możliwości opanowania krwawienia. Wobec powyższego obrazu podjęto decyzję o wycięciu nerki lewej. Z uwagi na stwierdzone płaszczyznowe krwawienie w otaczających tkankach i brak pewności co do ostatecznej hemostazy zdecydowano wykonać packing – założono 6 serwet do przestrzeni zaotrzewnowej. We wczesnym okresie pooperacyjnym nie stwierdzono powikłań. Pacjent krążeniowo, oddechowo i nerkowo wydolny. W 3. dobie od zabiegu w trybie planowym usuni

How is their word knowledge growing? Exploring Grade 3 vocabulary in South African township schools

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Elizabeth J. Pretorius

2017-11-01

Full Text Available In this article, we report on a study that examined the active and receptive English vocabulary of two different groups of Grade 3 learners in South African township schools. The groups consisted of English Home Language (HL learners in the Western Cape and Xhosa HL and English First Additional Language (FAL learners in the Eastern Cape. The purpose was to document their different vocabulary trajectories during Grade 3. The Woodcock-Muñoz Language Survey was used to measure the active vocabulary levels of 118 learners at the beginning and the end of the school year. Another 284 learners from the same eight Grade 3 classes participated in a receptive vocabulary test at the end of the year. This test assessed their knowledge of the 60 most frequent words that occur in South Africa Grade 4 English textbooks. Results showed that although the HL learners knew almost double the number of words their English FAL peers did, both groups of learners increased their active word knowledge through the year by about 9%. Regarding their receptive vocabulary, the English FAL learners on average only knew 27% of the most frequent words at the end of their Grade 3. No significant gender differences were found. Learners in both language groups who were above their grade age had significantly lower scores than their younger peers. This confirms findings that children who start school with weak language skills tend to stay weak. Finally, initial active vocabulary knowledge was found to be a strong predictor of vocabulary development during the school year.

Energetic consumption levels and human development indexes

International Nuclear Information System (INIS)

Boa Nova, Antonio Carlos

1999-01-01

The article overviews the energetic consumption levels and human development indexes. The human development indexes are described based on the United Nations Development Programme. A comparison between the energetic consumption levels and human development indexes is also presented

Development of Probabilistic and Possebilistic Approaches to Approximate Reasoning and Its Applications

Science.gov (United States)

1989-10-31

fo tmaa OmfuogeM ara Mmi. fal in fM?05V~ ~ ~ ~ ~ ~ A D A 2 4 0409"~ n ugt Psoo,@’ oducbof Proton (07044 136M. WagaWapN. DC 20141 T1 3. REPORT TYPE...Al (circumscription, non- monotonic reasoning, and default reasoning), our approach is based on fuzzy logic and, more specifically, on the theory of

Experimental and Theoretical Studies of the Acid-Catalyzed Conversion of Furfuryl Alcohol to Levulinic Acid in Aqueous Solution

Energy Technology Data Exchange (ETDEWEB)

Gonzalez Maldonado, Gretchen M.; Assary, Rajeev S.; Dumesic, James A.; Curtiss, Larry A.

2012-02-14

The conversion of furfuryl alcohol (FAL) to levulinic acid over Amberlyst TM 15 in aqueous media was investigated using a combination of liquid chromatography-mass spectrometry (LC-MS) measurements, isotopic labeling studies, nuclear magnetic resonance (NMR) spectroscopy, and ab initio quantum chemical calculations using the G4MP2 method. The results of these combined studies showed that one of the major reaction pathways takes place via a geminal diol species (4,5,5- trihydroxypentan-2-one, denoted as intermediate A), formed by the addition of two water molecules to FAL, where two of the oxygen atoms from FAL are retained. This geminal diol species can also be produced from another intermediate found to be a dimer-like species, denoted as intermediate B. This dimer-like species is formed at the early stages of reaction, and it can also be converted to intermediate A, indicating that intermediate B is the product of the reaction of FAL with another early intermediate. Quantum chemical calculations suggested this to be a protonated acyclic species. Reaction of this early intermediate with water produces intermediate A, while reaction with FAL produces intermediate B.

Experimental and Theoretical Studies of the Acid-Catalyzed Conversion of Furfuryl Alcohol to Levulinic Acid in Aqueous Solution

Energy Technology Data Exchange (ETDEWEB)

Gonzalez Maldonado, Gretchen; Assary, Rajeev S.; Dumesic, James A; Curtiss, Larry A

2012-01-01

The conversion of furfuryl alcohol (FAL) to levulinic acid over Amberlyst^TM 15 in aqueous media was investigated using a combination of liquid chromatography-mass spectrometry (LC-MS) measurements, isotopic labeling studies, nuclear magnetic resonance (NMR) spectroscopy, and ab initio quantum chemical calculations using the G4MP2 method. The results of these combined studies showed that one of the major reaction pathways takes place via a geminal diol species (4,5,5-trihydroxypentan-2-one, denoted as intermediate A), formed by the addition of two water molecules to FAL, where two of the oxygen atoms from FAL are retained. This geminal diol species can also be produced from another intermediate found to be a dimer-like species, denoted as intermediate B. This dimer-like species is formed at the early stages of reaction, and it can also be converted to intermediate A, indicating that intermediate B is the product of the reaction of FAL with another early intermediate. Quantum chemical calculations suggested this to be a protonated acyclic species. Reaction of this early intermediate with water produces intermediate A, while reaction with FAL produces intermediate B.

Effects of high temperature surface oxides on room temperature aqueous corrosion and environmental embrittlement of iron aluminides

Energy Technology Data Exchange (ETDEWEB)

Buchanan, R.A.; Perrin, R.L.

1996-09-01

Studies were conducted to determine the effects of high-temperature surface oxides, produced during thermomechanical processing, heat treatment (750 {degrees}C in air, one hour) or simulated in-service-type oxidation (1000{degrees}C in air, 24 hours) on the room-temperature aqueous-corrosion and environmental-embrittlement characteristics of iron aluminides. Materials evaluated included the Fe{sub 3}Al-based iron aluminides, FA-84, FA-129, FAL and FAL-Mo, a FeAl-based iron aluminide, FA-385, and a disordered low-aluminum Fe-Al alloy, FAPY. Tests were performed in a mild acid-chloride solution to simulate aggressive atmospheric corrosion. Cyclic-anodic-polarization tests were employed to evaluate resistances to localized aqueous corrosion. The high-temperature oxide surfaces consistently produced detrimental results relative to mechanically or chemically cleaned surfaces. Specifically, the pitting corrosion resistances were much lower for the as-processed and 750{degrees} C surfaces, relative to the cleaned surfaces, for FA-84, FA-129, FAL-Mo, FA-385 and FAPY. Furthermore, the pitting corrosion resistances were much lower for the 1000{degrees}C surfaces, relative to cleaned surfaces, for FA-129, FAL and FAL-Mo.

Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 573: Alpha Contaminated Sites Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Matthews, Patrick [Nevada Site Office, Las Vegas, NV (United States)

2016-02-01

CAU 573 comprises the following corrective action sites (CASs): • 05-23-02, GMX Alpha Contaminated Area • 05-45-01, Atmospheric Test Site - Hamilton These two CASs include the release at the Hamilton weapons-related tower test and a series of 29 atmospheric experiments conducted at GMX. The two CASs are located in two distinctly separate areas within Area 5. To facilitate site investigation and data quality objective (DQO) decisions, all identified releases (i.e., CAS components) were organized into study groups. The reporting of investigation results and the evaluation of DQO decisions are at the release level. The corrective action alternatives (CAAs) were evaluated at the FFACO CAS level. The purpose of this CADD/CAP is to evaluate potential CAAs, provide the rationale for the selection of recommended CAAs, and provide the plan for implementation of the recommended CAA for CAU 573. Corrective action investigation (CAI) activities were performed from January 2015 through November 2015, as set forth in the CAU 573 Corrective Action Investigation Plan (CAIP). Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the contaminants of concern. Assessment of the data generated from investigation activities conducted at CAU 573 revealed the following: • Radiological contamination within CAU 573 does not exceed the FALs (based on the Occasional Use Area exposure scenario). • Chemical contamination within CAU 573 does not exceed the FALs. • Potential source material—including lead plates, lead bricks, and lead-shielded cables—was removed during the investigation and requires no additional corrective action.

Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 573: Alpha Contaminated Sites Nevada National Security Site, Nevada, Revision 0

International Nuclear Information System (INIS)

Matthews, Patrick

2016-01-01

CAU 573 comprises the following corrective action sites (CASs): • 05-23-02, GMX Alpha Contaminated Area • 05-45-01, Atmospheric Test Site - Hamilton These two CASs include the release at the Hamilton weapons-related tower test and a series of 29 atmospheric experiments conducted at GMX. The two CASs are located in two distinctly separate areas within Area 5. To facilitate site investigation and data quality objective (DQO) decisions, all identified releases (i.e., CAS components) were organized into study groups. The reporting of investigation results and the evaluation of DQO decisions are at the release level. The corrective action alternatives (CAAs) were evaluated at the FFACO CAS level. The purpose of this CADD/CAP is to evaluate potential CAAs, provide the rationale for the selection of recommended CAAs, and provide the plan for implementation of the recommended CAA for CAU 573. Corrective action investigation (CAI) activities were performed from January 2015 through November 2015, as set forth in the CAU 573 Corrective Action Investigation Plan (CAIP). Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the contaminants of concern. Assessment of the data generated from investigation activities conducted at CAU 573 revealed the following: • Radiological contamination within CAU 573 does not exceed the FALs (based on the Occasional Use Area exposure scenario). • Chemical contamination within CAU 573 does not exceed the FALs. • Potential source material - including lead plates, lead bricks, and lead-shielded cables was removed during the investigation and requires no additional corrective action.

The new European legal culture: ten years on

NARCIS (Netherlands)

Hesselink, M.W.

2009-01-01

New postscript to: Hesselink, M.W. & Wei, L. (2010). --- Xin de ouzhou falü wenhua. --- Beijing: Zhongguo falü chubanshe. This is the Chinese translation of: Hesselink, M.W. (2001). --- The new European legal culture. --- Deventer : Kluwer. That essay argued that Europe was facing a shift from a

High-Level Development of Multiserver Online Games

Directory of Open Access Journals (Sweden)

Frank Glinka

2008-01-01

Full Text Available Multiplayer online games with support for high user numbers must provide mechanisms to support an increasing amount of players by using additional resources. This paper provides a comprehensive analysis of the practically proven multiserver distribution mechanisms, zoning, instancing, and replication, and the tasks for the game developer implied by them. We propose a novel, high-level development approach which integrates the three distribution mechanisms seamlessly in today's online games. As a possible base for this high-level approach, we describe the real-time framework (RTF middleware system which liberates the developer from low-level tasks and allows him to stay at high level of design abstraction. We explain how RTF supports the implementation of single-server online games and how RTF allows to incorporate the three multiserver distribution mechanisms during the development process. Finally, we describe briefly how RTF provides manageability and maintenance functionality for online games in a grid context with dynamic resource allocation scenarios.

Influence of the Atmospheric Model on Hanle Diagnostics

Science.gov (United States)

Ishikawa, Ryohko; Uitenbroek, Han; Goto, Motoshi; Iida, Yusuke; Tsuneta, Saku

2018-05-01

We clarify the uncertainty in the inferred magnetic field vector via the Hanle diagnostics of the hydrogen Lyman-α line when the stratification of the underlying atmosphere is unknown. We calculate the anisotropy of the radiation field with plane-parallel semi-empirical models under the nonlocal thermal equilibrium condition and derive linear polarization signals for all possible parameters of magnetic field vectors based on an analytical solution of the atomic polarization and Hanle effect. We find that the semi-empirical models of the inter-network region (FAL-A) and network region (FAL-F) show similar degrees of anisotropy in the radiation field, and this similarity results in an acceptable inversion error ( e.g., {˜} 40 G instead of 50 G in field strength and {˜} 100° instead of 90° in inclination) when FAL-A and FAL-F are swapped. However, the semi-empirical models of FAL-C (averaged quiet-Sun model including both inter-network and network regions) and FAL-P (plage regions) yield an atomic polarization that deviates from all other models, which makes it difficult to precisely determine the magnetic field vector if the correct atmospheric model is not known ( e.g., the inversion error is much larger than 40% of the field strength; {>} 70 G instead of 50 G). These results clearly demonstrate that the choice of model atmosphere is important for Hanle diagnostics. As is well known, one way to constrain the average atmospheric stratification is to measure the center-to-limb variation of the linear polarization signals. The dependence of the center-to-limb variations on the atmospheric model is also presented in this paper.

Classificação de gravidade na pancreatite aguda

Directory of Open Access Journals (Sweden)

Tercio De Campos

Full Text Available De acordo com a Classificação de Atlanta a pancreatite aguda pode ser dividida, baseado em sua severidade, em uma forma leve ou grave. Uma série de aspectos têm sido discutidos nos últimos anos, tais como, quantas categorias de gravidade devem ser consideradas; se o doente com falência orgânica é igual ao doente com necrose infectada; qual o papel da falência orgânica transitória; e como avaliar a falência orgânica. A reunião de revista"Telemedicina Baseada em Evidência - Cirurgia do Trauma e Emergência" (TBE-CiTE realizou uma avaliação crítica de artigos relacionados a este tema, considerando três artigos recentes que delinearam duas grandes revisões publicadas nos últimos meses. Estes artigos sugerem a classificação de gravidade em três ou quatro categorias, ao invés de pancreatite aguda leve ou grave, além de discutir qual o melhor escore para avaliar a falência orgânica. As seguintes recomendações foram propostas: (1 A pancreatite aguda deve ser classificada em quatro categorias: leve, moderada, grave e crítica, o que permite uma melhor determinação das características dos doentes; (2 Avaliação de falência orgânica com um escore de gravidade, preferencialmente algum que avalie diretamente cada falência orgânica, tais como o SOFA e o MODS (Marshall. O SOFA parece ter maior acurácia, mas o MODS tem melhor aplicabilidade devido à facilidade de uso.

Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.

Science.gov (United States)

Ghadge, Ghanashyam D; Pavlovic, John D; Koduvayur, Sujatha P; Kay, Brian K; Roos, Raymond P

2013-08-01

Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (known as FALS) with an autosomal dominant inheritance pattern, and ~25% of FALS cases are caused by mutations in Cu/Zn superoxide dismutase (SOD1). There is convincing evidence that mutant SOD1 (mtSOD1) kills motor neurons (MNs) because of a gain-of-function toxicity, most likely related to aggregation of mtSOD1. A number of recent reports have suggested that antibodies can be used to treat mtSOD1-induced FALS. To follow up on the use of antibodies as potential therapeutics, we generated single chain fragments of variable region antibodies (scFvs) against SOD1, and then expressed them as 'intrabodies' within a motor neuron cell line. In the present study, we describe isolation of human scFvs that interfere with mtSOD1 in vitro aggregation and toxicity. These scFvs may have therapeutic potential in sporadic ALS, as well as FALS, given that sporadic ALS may also involve abnormalities in the SOD1 protein or activity. Copyright © 2013 Elsevier Inc. All rights reserved.

Corrective Action Decision Document/Closure Report for Corrective Action Unit 560: Septic Systems, Nevada Test Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Grant Evenson

2010-04-01

Corrective Action Unit 560 comprises seven corrective action sites (CASs): •03-51-01, Leach Pit •06-04-02, Septic Tank •06-05-03, Leach Pit •06-05-04, Leach Bed •06-59-03, Building CP-400 Septic System •06-59-04, Office Trailer Complex Sewage Pond •06-59-05, Control Point Septic System The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure of CAU 560 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from October 7, 2008, through February 24, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 560: Septic Systems, Nevada Test Site, Nevada, and Record of Technical Change No. 1. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: •Determine whether contaminants of concern (COCs) are present. •If COCs are present, determine their nature and extent. •Provide sufficient information and data to complete appropriate corrective actions. The CAU 560 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. The following contaminants were determined to be present at concentrations exceeding their corresponding FALs: •No contamination exceeding the FALs was identified at CASs 03-51-01, 06-04-02, and 06-59-04. •The soil at the base of the leach pit chamber at CAS 06-05-03 contains arsenic above the FAL of 23 milligrams per kilogram (mg/kg) and polychlorinated biphenyl (PCBs) above the FAL of 0.74 mg/kg, confined vertically from a depth of approximately 5 to 20 feet (ft) below ground surface. The contamination is confined laterally to the walls of the

Development Track of Different County-Level Towns

OpenAIRE

ZHANG, Haijiao; ZHANG, Zhenghe

2015-01-01

County-level town is important space carrier of China’s urbanization and the emphasis and key of strategic distribution for urbanization. Backwardness of county-level towns limits nearby transfer of surplus labor. To promote development of county-level towns, on the basis of classifying county-level towns, this paper analyzed motive and resistance factors of evolution of different county-level towns using historical data collection and statistical method, comparative approach, typical case ...

Industrial Sites Project Establishment of Final Action Levels

International Nuclear Information System (INIS)

Boehlecke, Robert F.

2006-01-01

The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

Classroom-Level Teacher Professional Development and Satisfaction: Teachers Learn in the Context of Classroom-Level Curriculum Development

Science.gov (United States)

Shawer, Saad

2010-01-01

This qualitative study examined the impact of classroom-level teacher professional development (CTPD) and curriculum transmission on teacher professional development and satisfaction. Based on work with English-as-a-foreign-language college teachers and students, data analysis showed that CTPD significantly improved student-teacher subject,…

Low-level radioactive waste management technology development

International Nuclear Information System (INIS)

Coleman, J.A.

1985-01-01

Although reviews of disposal practices and site performance indicated that there were no releases to the environment that would affect public health and safety, it became clear that: (a) several burial grounds were not performing as expected; (b) long-term maintenance of closed trenches could be a costly problem, and (c) more cost-effective methods could be developed for the treatment, packing, and disposal of low-level waste. As a result of these reviews, the Department of Energy developed the Low-level Waste Management Program to seek improvements in existing practices, correct obvious deficiencies, and develop site closure techniques that would avoid expensive long-term maintenance and monitoring. Such technology developments provide a better understanding of the physical and technical mechanisms governing low-level waste treatment and disposal and lead to improvement in the performance of disposal sites. The primary means of disposal of low-level waste has been the accepted and regulated practice of shallow land disposal, i.e., placement of low-level waste in trenches 5 to 10 meters deep with several meters of special soil cover. Department of Energy waste is primarily disposed at six major shallow land disposal sites. Commercial waste is currently disposed of at three major sites in the nation - Barnwell, South Carolina; Richland, Washington; and Beatty, Nevada. In the late 1970's public concern arose regarding the management practices of sites operated by the civilian sector and by the Department of Energy

Accident sequence precursor analysis level 2/3 model development

International Nuclear Information System (INIS)

Lui, C.H.; Galyean, W.J.; Brownson, D.A.

1997-01-01

The US Nuclear Regulatory Commission's Accident Sequence Precursor (ASP) program currently uses simple Level 1 models to assess the conditional core damage probability for operational events occurring in commercial nuclear power plants (NPP). Since not all accident sequences leading to core damage will result in the same radiological consequences, it is necessary to develop simple Level 2/3 models that can be used to analyze the response of the NPP containment structure in the context of a core damage accident, estimate the magnitude of the resulting radioactive releases to the environment, and calculate the consequences associated with these releases. The simple Level 2/3 model development work was initiated in 1995, and several prototype models have been completed. Once developed, these simple Level 2/3 models are linked to the simple Level 1 models to provide risk perspectives for operational events. This paper describes the methods implemented for the development of these simple Level 2/3 ASP models, and the linkage process to the existing Level 1 models

A interdisciplinaridade na legislação educacional, no discurso acadêmico e na prática escolar do ensino médio: panaceia ou falácia educacional?

Directory of Open Access Journals (Sweden)

Erika Regina Mozena

2016-04-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2016v33n1p92 O discurso da interdisciplinaridade no Brasil tem sido apropriado por grande parte da legislação educacional desde a década de 70 com o sentido de responsabilizá-la por elevar a educação a patamares superiores de qualidade. Na mesma direção, crescem vertiginosamente os trabalhos de pesquisa na área de educação, que apontam a importância da interdisciplinaridade no contexto atual. Por outro lado, tanto esses documentos legais como os meios acadêmicos outorgam ao professor o papel de desenvolver e implementar a interdisciplinaridade na sala de aula. O que se observa em trabalhos de pesquisa que investigam a prática dos professores é que estes se contentam em empreender projetos que julgam interdisciplinares, mas que em sua grande maioria não passam de multidisciplinares, apoiados no senso comum. Este quadro coloca o discurso da interdisciplinaridade com feições de uma falácia educacional. Este trabalho discute a insistência histórica da legislação e do meio acadêmico em tornar este discurso um grande objeto do desejo educacional. Já com relação aos professores, procura localizar as razões pelas quais eles não se aprofundam nessa prática além do senso comum, análise apoiada na epistemologia da prática docente como pensada por Tardif e Lessard, que justifica as ações dos professores com base nas características intrínsecas das situações do trabalho interativo.

Effect of Thermal Maturation on n-alkanes and Kerogen in Preserved Organic Matter: Implications for Paleoenvironment Biomarkers

Science.gov (United States)

Craven, O. D.; Longbottom, T. L.; Hockaday, W. C.; Blackaby, E.

2017-12-01

Understanding the effects of maturity on biomarkers is vital in assessing biomarker reliability in mature sediments. It is well known for n-alkanes that increased maturity shortens chain lengths and decreases the odd over even preference however, the amount of change in these variables has not been determined for different maturities and types of preserved organic matter. For this reason, it is difficult to judge the trustworthiness of even lightly matured samples for paleoenvironment reconstruction. Another complication is the difficulty of accurately determining maturity as many maturity indicators are error-prone or not appropriate at low maturities. Using hydrous pyrolysis, we artificially matured black shale samples with type I (lacustrine) and type II (marine) kerogen to measure changes in n-alkane length and odd over even preference. Whole rock samples underwent hydrous pyrolysis for 72 hours, at 250 °C, 300 °C, 325 °C, 350 °C, and 375 °C to cover a wide maturity range. From the immature and artificially matured samples, the bitumen was extracted and the saturate fraction was separated using column chromatography. The saturate fraction was analyzed for n-alkanes using gas chromatography-mass spectroscopy. Kerogen structural changes were also measured using solid-state 13C NMR to relate changes in n-alkane biomarkers to changes in kerogen structure. Results show that for type I bitumen the n-alkanes did not change at low maturities considered premature in terms of oil generation (<325 °C). The NMR spectra of the type I kerogen support the lack of change, at low maturities no changes in the aliphatic portion (Fal) were observed, however, after 325 °C Fal decreased with increasing maturity. The loss of Fal indicates kerogen contributing hydrocarbons to bitumen that cause changes in n-alkane measurements. The type II kerogen's Fal also decreased with increasing maturity, but unlike the type I kerogen Fal loss started at low maturities. The differences

Developing Mathematics Problems Based on Pisa Level

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Shahibul Ahyan

2014-01-01

Full Text Available This research aims to produce mathematics problems based on PISA level with valid and practical content of change and relationships and has potential effect for Junior High School students. A development research method developed by Akker, Gravemeijer, McKenney and Nieveen is used this research. In the first stage, the researcher analyzed students, algebra material in school-based curricula (KTSP and mathematics problems of PISA 2003 of change and relationships content. The second stage, the researcher designed 13 problems with content of change and relationships. The last, the researcher used formative evaluation design developed by Tessmer which includes self evaluation, one-to-one, expert review, small group, and field test. The data collect by walk through, interview, and questionnaire. The result of this research indicated that 12 mathematical problems based on PISA level of change and relationships content that developed have validity, practically, and potential effects for Junior High School students.

Programmable pseudo-random detector-pulse-pattern generator

International Nuclear Information System (INIS)

Putten, R. van der; Nationaal Inst. voor Kernfysica en Hoge-Energiefysica

1990-01-01

This report discusses the design and realization of the digital part of the programmable pseudo-random detector pulse-pattern generator. For the design and realization use has been made of F-TTL and high speed special purpose ic's, in particular FAL's (15 ns). The design possibilities offered by the software for pro-gramming of the FAL's have been utilized as much as possible. In this way counters, registers and a state machine with extended control possibilities have been designed and an advanced 8 channel pulse generator has been developed which is controlled via the VME system bus. the generator possesses an internal clock oscillator of 16 MHZ. The moment when a pulse is generated can be adjusted with a step size of 250 ps. 2000 different periods (time windows) can be stored for generating a pattern. (author). 37 refs.; 6 figs

Fluoride or/and aluminum induced toxicity in guinea pig teeth with the low expression of dentine phosphoprotein.

Science.gov (United States)

Han, Tianlong; Wang, Min; Cao, Chunfang; Chen, Huacheng; Zhang, Guanghe; Wang, Liping; Wang, Jundong

2017-08-01

This study investigated the damage and expression of dentine phosphoprotein (DPP) in guinea pig teeth by the administration of fluoride (F) or/and aluminum (Al). Fifty-two guinea pigs were divided randomly into four groups (control, F, Al, and F+Al). F (150 mg NaF/L) or/and Al (300 mg AlCl 3 /L) were added in their drinking water for 90 days. The levels of F ion, dentine sialophosphoprotein (DSPP) gene, and DPP protein in incisor and molar were determined, respectively. The results showed that the concentrations of F ion in F and F+Al groups were increased significantly. F induced the mottled enamel and irregular abrasion of teeth, which might occur as a consequence of depressed DSPP mRNA and DPP protein expression. Both the gene and protein expressions showed obvious decrease induced by Al, especially by F. There were no synergistic effects between F and Al, instead, Al inhibited the toxicity of F. © 2017 Wiley Periodicals, Inc.

Development of reactor water level sensor for extreme conditions

Energy Technology Data Exchange (ETDEWEB)

Miura, K; Ogasawara, T [Sukegawa Electric Co., Ltd., Hitachi, Ibaraki (Japan); Shibata, Akira; Nakamura, Jinichi; Saito, Takashi; Tsuchiya, Kunihiko [Japan Atomic Energy Agency, Oarai Research and Development Center, Oarai, Ibaraki (Japan)

2012-03-15

In the Fukushima accident, measurement failure of water level was one of the most important factors which caused serious situation. The differential pressure type water level indicators are widely used in various place of nuclear power plant but after the accident of TMI-2, the need of other reliable method has been required. The BICOTH type and the TRICOTH type water level indicator for light water power reactors had been developed for in-pile water level indicator but currently those are not adopted to nuclear power plant. In this study, the development of new type water level indicator composed of thermocouple and heater is described. Demonstration test and characteristic evaluation of the water level indicator were performed and we had obtained satisfactory results. (author)

13C-NMR Study on Structure Evolution Characteristics of High-Organic-Sulfur Coals from Typical Chinese Areas

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Qiang Wei

2018-02-01

Full Text Available The structure evolution characteristics of high-organic-sulfur (HOS coals with a wide range of ranks from typical Chinese areas were investigated using 13C-CP/MAS NMR. The results indicate that the structure parameters that are relevant to coal rank include CH3 carbon (fal*, quaternary carbon, CH/CH2 carbon + quaternary carbon (falH, aliphatic carbon (falC, protonated aromatic carbon (faH, protonated aromatic carbon + aromatic bridgehead carbon (faH+B, aromaticity (faCP, and aromatic carbon (farC. The coal structure changed dramatically in the first two coalification jumps, especially the first one. A large number of aromatic structures condensed, and aliphatic structures rapidly developed at the initial stage of bituminous coal accompanied by remarkable decarboxylation. Compared to ordinary coals, the structure evolution characteristics of HOS coals manifest in three ways: First, the aromatic CH3 carbon, alkylated aromatic carbon (faS, aromatic bridgehead carbon (faB, and phenolic ether (faP are barely relevant to rank, and abundant organic sulfur has an impact on the normal evolution process of coal. Second, the average aromatic cluster sizes of some super-high-organic-sulfur (SHOS coals are not large, and the extensive development of cross bonds and/or bridged bonds form closer connections among the aromatic fringes. Moreover, sulfur-containing functional groups are probably significant components in these linkages. Third, a considerable portion of “oxygen-containing functional groups” in SHOS coals determined by 13C-NMR are actually sulfur-containing groups, which results in the anomaly that the oxygen-containing structures increase with coal rank.

Adolescente autor de ato infracional: falência do pai ou falência da pátria?

OpenAIRE

Mattos, Luciana

2008-01-01

O presente trabalho objetiva realizar uma análise por meio de relatórios, laudos e avaliações elaborados por psicólogos e por assistentes sociais do Poder Judiciário, enfatizando-se as considerações acerca da dinâmica familiar, notadamente expressões como família desorganizada , fragilidade do pai e similares, as quais aparecem nesses documentos, em diálogo com a questão social. A construção desta pesquisa deu-se a partir do trabalho desenvolvido na qualidade de psicóloga...

Corrective Action Decision Document/Closure Report for Corrective Action Unit 482: Area 15 U15a/e Muckpiles and Ponds Nevada Test Site

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2009-09-30

This Corrective Action Decision Document /Closure Report (CADD/CR) was prepared by the Defense Threat Reduction Agency (DTRA) for Corrective Action Unit (CAU) 482 U15a/e Muckpiles and Ponds. This CADD/CR is consistent with the requirements of the Federal Facility Agreement and Consent Order agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Corrective Action Unit 482 is comprised of three Corrective Action Sites (CASs) and one adjacent area: CAS 15-06-01, U15e Muckpile; CAS 15-06-02, U15a Muckpile; CAS 15-38-01, Area 15 U15a/e Ponds; and Drainage below the U15a Muckpile. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure with no further corrective action, by placing use restrictions on the three CASs and the adjacent area of CAU 482. To support this recommendation, a corrective action investigation (CAI) was performed in September 2002. The purpose of the CAI was to fulfill the following data needs as defined during the Data Quality Objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to determine appropriate corrective actions. The CAU 482 dataset from the CAI was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Tier 2 FALS were determined for the hazardous constituents of total petroleum hydrocarbons (TPH)-diesel-range organics (DRO) and the radionuclides americium (Am)-241, cesium (Cs)-137, plutonium (Pu)-238, and Pu-239. The Tier 2 FALs were calculated for the radionuclides using site-specific information. The hazardous constituents of TPH-DRO were compared to the PALs

Corrective Action Decision Document/Closure Report for Corrective Action Unit 482: Area 15 U15a/e Muckpiles and Ponds Nevada Test Site

International Nuclear Information System (INIS)

2009-01-01

This Corrective Action Decision Document /Closure Report (CADD/CR) was prepared by the Defense Threat Reduction Agency (DTRA) for Corrective Action Unit (CAU) 482 U15a/e Muckpiles and Ponds. This CADD/CR is consistent with the requirements of the Federal Facility Agreement and Consent Order agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Corrective Action Unit 482 is comprised of three Corrective Action Sites (CASs) and one adjacent area: CAS 15-06-01, U15e Muckpile; CAS 15-06-02, U15a Muckpile; CAS 15-38-01, Area 15 U15a/e Ponds; and Drainage below the U15a Muckpile. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation for closure with no further corrective action, by placing use restrictions on the three CASs and the adjacent area of CAU 482. To support this recommendation, a corrective action investigation (CAI) was performed in September 2002. The purpose of the CAI was to fulfill the following data needs as defined during the Data Quality Objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to determine appropriate corrective actions. The CAU 482 dataset from the CAI was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Tier 2 FALS were determined for the hazardous constituents of total petroleum hydrocarbons (TPH)-diesel-range organics (DRO) and the radionuclides americium (Am)-241, cesium (Cs)-137, plutonium (Pu)-238, and Pu-239. The Tier 2 FALs were calculated for the radionuclides using site-specific information. The hazardous constituents of TPH-DRO were compared to the PALs

DOE low-level waste long term technology development

International Nuclear Information System (INIS)

Barainca, M.J.

1982-01-01

The objective of the Department of Energy's Low-Level Waste Management Program is to provide a low-level waste management system by 1986. Areas of concentration are defined as: (1) Waste Generation Reduction Technology, (2) Process and Handling Technology, (3) Environmental Technology, (4) Low-Level Waste Disposal Technology. A program overview is provided with specific examples of technical development. 2 figures

A Study of Army Civilian Entry Level and Mid-Level Program Management Leadership Development

Science.gov (United States)

2016-05-08

and mid-grade level positions is an important responsibility for senior leaders. Mentoring and coaching entry level and mid-grade level...Program Management Leadership Development Craig J. Maurice Defense Acquisition University Senior Service College Fellowship 2015-2016 Huntsville...requirements for the Army’s Senior Service College Fellowship (SSCF) under the direction of SSCF Director, Mr. John Daniels and Research Advisor, Mr. Van

Development and validation of a behavioural assay to measure the tolerance of Hediste diversicolor to copper

International Nuclear Information System (INIS)

Burlinson, Frazer C.; Lawrence, Andrew J.

2007-01-01

The behaviour of Hediste diversicolor from the Humber was investigated under different concentrations of copper sulphate. A range of behaviours were indicative of metal-stress. These included consistent attempts at burrowing, eversion of the proboscis and abnormal crawling. The bioassay itself consisted of exposing worms to increasing concentrations of copper sulphate and recording the concentration at which a stress response was elicited. The behavioural end-points were shown to be a good predictor of time of death of Fal estuary worms under acutely toxic conditions. The bioassay would therefore allow the separation of tolerance phenotypes without mortality to the worm. Worms were not affected by consecutive bioassays and it was proposed that tolerance to more than one metal could be determined for individual worms. - A non-destructive behavioural bioassay is developed to determine the copper tolerance of ragworms

Physics Identity Development: A Snapshot of the Stages of Development of Upper-Level Physics Students

Science.gov (United States)

Irving, Paul W.; Sayre, Eleanor C.

2013-01-01

As part of a longitudinal study into identity development in upper-level physics students a phenomenographic research method is employed to assess the stages of identity development of a group of upper-level students. Three categories of description were discovered which indicate the three different stages of identity development for this group…

Development of radiation detection and measurement systems - Development of level gauge and density gauge

Energy Technology Data Exchange (ETDEWEB)

Ma, Su Man; Kim, Sung Hun; Jang, Jung Hun; Yun, Mung Hun; Yun Jun Hyung; Kang, Sung Youn [Techvalley co., Ltd., Research Center, Seoul (Korea)

2000-03-01

-Pervasive effect of R and D results. Technical development of level/density measuring instruments has a definitely significant effect on the quality test of various products in the filled on the heavy industry. As measurement of flow increasingly becomes important in the plant design in the chemical industry, development of our products is applicable to various equipment in the field of industries. -Applications of R and D results. Technical development of level/density measurement copes with a technical difficulty in inspecting the internal conditions of chemical plants by transmission through metal materials in a non-destructive manner and thereby enables non-destructive flow and level tests in the field of industries. 11 refs., 19 figs., 4 tabs. (Author)

Development of a low-level radioactive waste shipper model. National Low-Level Radioactive Waste Management Program

International Nuclear Information System (INIS)

1983-03-01

During 1982, Inter/Face Associates, Inc., conducted a low-level radioactive waste management survey of Nuclear Regulatory Commission (NRC) licensees in Massachusetts for the US Department of Energy's National Low-Level Waste Management Program. In the process of conducting the survey, a model was developed, based on existing NRC license classification systems, that would identify licensees who ship low-level waste for disposal. This report presents the model and documents the procedures used in developing and testing it. After the model was tested, several modifications were developed with the goal of determining the model's ability to identify waste shippers under different parameters. The report includes a discussion of the modifications

Definition of Technology Readiness Levels for Transmutation Fuel Development

International Nuclear Information System (INIS)

Jon Carmack; Kemal O. Pasamehmetoglu

2008-01-01

To quantitatively assess the maturity of a given technology, the Technology Readiness Level (TRL) process is used. The TRL process has been developed and successfully used by the Department of Defense (DOD) for development and deployment of new technology and systems for defense applications. In addition, NASA has also successfully used the TRL process to develop and deploy new systems for space applications. Transmutation fuel development is a critical technology needed for closing the nuclear fuel cycle. Because the deployment of a new nuclear fuel forms requires a lengthy and expensive research, development, and demonstration program, applying the TRL concept to the transmutation fuel development program is very useful as a management and tracking tool. This report provides definition of the technology readiness level assessment process as defined for use in assessing nuclear fuel technology development for the Transuranic Fuel Development Campaign

The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis.

Science.gov (United States)

Marayati, Bahjat Fadi; Hoskins, Victoria; Boger, Robert W; Tucker, James F; Fishman, Emily S; Bray, Andrew S; Zhang, Ke

2016-09-01

Meiosis is a highly regulated process by which genetic information is transmitted through sexual reproduction. It encompasses unique mechanisms that do not occur in vegetative cells, producing a distinct, well-regulated meiotic transcriptome. During vegetative growth, many meiotic genes are constitutively transcribed, but most of the resulting mRNAs are rapidly eliminated by the Mmi1-MTREC (Mtl1-Red1 core) complex. While Mmi1-MTREC targets premature meiotic RNAs for degradation by the nuclear 3'-5' exoribonuclease exosome during mitotic growth, its role in meiotic gene expression during meiosis is not known. Here, we report that Red5, an essential MTREC component, interacts with pFal1, an ortholog of eukaryotic translation initiation factor eIF4aIII in the fission yeast Schizosaccharomyces pombe In mammals, together with MAGO (Mnh1), Rnps1, and Y14, elF4AIII (pFal1) forms the core of the exon junction complex (EJC), which is essential for transcriptional surveillance and localization of mature mRNAs. In fission yeast, two EJC orthologs, pFal1 and Mnh1, are functionally connected with MTREC, specifically in the process of meiotic gene expression during meiosis. Although pFal1 interacts with Mnh1, Y14, and Rnps1, its association with Mnh1 is not disrupted upon loss of Y14 or Rnps1. Mutations of Red1, Red5, pFal1, or Mnh1 produce severe meiotic defects; the abundance of meiotic transcripts during meiosis decreases; and mRNA maturation processes such as splicing are impaired. Since studying meiosis in mammalian germline cells is difficult, our findings in fission yeast may help to define the general mechanisms involved in accurate meiotic gene expression in higher eukaryotes. © 2016 Marayati et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Recent Developments in Low-Level Software Security

OpenAIRE

Agten , Pieter; Nikiforakis , Nick; Strackx , Raoul; Groef , Willem ,; Piessens , Frank

2012-01-01

Part 1: Keynotes; International audience; An important objective for low-level software security research is to develop techniques that make it harder to launch attacks that exploit implementation details of the system under attack. Baltopoulos and Gordon have summarized this as the principle of source-based reasoning for security: security properties of a software system should follow from review of the source code and its source-level semantics, and should not depend on details of the compi...

Nascent Entrepreneurship and the Level of Economic Development

NARCIS (Netherlands)

A.R.M. Wennekers (Sander); A.J. van Stel (André); A.R. Thurik (Roy); P. Reynolds (Paul)

2005-01-01

textabstractBased upon two strands of literature, this paper hypothesizes a U-shaped relationship between a country’s rate of entrepreneurial dynamics and its level of economic development. This would imply a different scope for entrepreneurship policy across subsequent stages of development.

FAL Clowes, 1921-2016: a Memoir.

Science.gov (United States)

Barlow, Peter W

2018-03-04

With the death of Frederick Albert Lionel Clowes on 21 September 2016, plant sciences lost a member of that lineage of experimental morphologists which reaches back to Johann Wolfgang von Goethe. In 1949, he discovered a group of cells at the tip of the beech root apex which were metabolically inert. In 1954, he confirmed generality of this root apex feature and coined the term 'quiescent center'. He continued to study these unique cells throughout next decades up to his last papers published in 1980s. Concept of the quiescent centre of plant roots is one of the milestones in plant cell biology and plant physiology.

Corrective Action Decision Document/Closure Report for Corrective Action Unit 106: Area 5, 11 Frenchman Flat Atmospheric Sites, Nevada National Security Site, Nevada

International Nuclear Information System (INIS)

Matthews, Patrick; Peterson, Dawn

2011-01-01

Corrective Action Unit 106 comprises four corrective action sites (CASs): (1) 05-20-02, Evaporation Pond; (2) 05-23-05, Atmospheric Test Site - Able; (3) 05-45-04, 306 GZ Rad Contaminated Area; (4) 05-45-05, 307 GZ Rad Contaminated Area. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 106 based on the implementation of corrective actions. The corrective action of clean closure was implemented at CASs 05-45-04 and 05-45-05, while no corrective action was necessary at CASs 05-20-02 and 05-23-05. Corrective action investigation (CAI) activities were performed from October 20, 2010, through June 1, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 106: Areas 5, 11 Frenchman Flat Atmospheric Sites. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of other releases (mechanical displacement and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 106 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is complete and acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Industrial Area exposure scenario (2,250 hours of annual exposure). The only radiological dose exceeding the FAL was at CAS 05-45-05 and was associated with potential source material (PSM). It is also assumed that additional PSM in the form of depleted uranium (DU) and DU-contaminated debris at CASs 05-45-04 and 05-45-05 exceed the FAL. Therefore, corrective actions were undertaken at these CASs that consisted of removing PSM and collecting verification

Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 413: Clean Slate II Plutonium Dispersion (TTR) Tonopah Test Range, Nevada. Revision 0

Energy Technology Data Exchange (ETDEWEB)

Matthews, Patrick [Navarro, Las Vegas, NV (United States)

2017-05-01

This Corrective Action Decision Document/Corrective Action Plan provides the rationale and supporting information for the selection and implementation of corrective actions at Corrective Action Unit (CAU) 413, Clean Slate II Plutonium Dispersion (TTR). CAU 413 is located on the Tonopah Test Range and includes one corrective action site, TA-23-02CS. CAU 413 consists of the release of radionuclides to the surface and shallow subsurface from the Clean Slate II (CSII) storage–transportation test conducted on May 31, 1963. The CSII test was a non-nuclear detonation of a nuclear device located inside a concrete bunker covered with 2 feet of soil. To facilitate site investigation and the evaluation of data quality objectives decisions, the releases at CAU 413 were divided into seven study groups: 1 Undisturbed Areas 2 Disturbed Areas 3 Sedimentation Areas 4 Former Staging Area 5 Buried Debris 6 Potential Source Material 7 Soil Mounds Corrective action investigation (CAI) activities, as set forth in the CAU 413 Corrective Action Investigation Plan, were performed from June 2015 through May 2016. Radionuclides detected in samples collected during the CAI were used to estimate total effective dose using the Construction Worker exposure scenario. Corrective action was required for areas where total effective dose exceeded, or was assumed to exceed, the radiological final action level (FAL) of 25 millirem per year. The results of the CAI and the assumptions made in the data quality objectives resulted in the following conclusions: The FAL is exceeded in surface soil in SG1, Undisturbed Areas; The FAL is assumed to be exceeded in SG5, Buried Debris, where contaminated debris and soil were buried after the CSII test; The FAL is not exceeded at SG2, SG3, SG4, SG6, or SG7. Because the FAL is exceeded at CAU 413, corrective action is required and corrective action alternatives (CAAs) must be evaluated. For CAU 413, three CAAs were evaluated: no further action, clean closure, and

Novel homozygous FANCL mutation and somatic heterozygous SETBP1 mutation in a Chinese girl with Fanconi Anemia.

Science.gov (United States)

Wu, Weiqing; Liu, Yang; Zhou, Qinghua; Wang, Qin; Luo, Fuwei; Xu, Zhiyong; Geng, Qian; Li, Peining; Zhang, Hui Z; Xie, Jiansheng

2017-07-01

Fanconi Anemia (FA) is a rare genetically heterogeneous disorder with 17 known complement groups caused by mutations in different genes. FA complementation group L (FA-L, OMIM #608111) occurred in 0.2% of all FA and only eight mutant variants in the FANCL gene were documented. Phenotype and genotype correlation in FANCL associated FA is still obscure. Here we describe a Chinese girl with FA-L caused by a novel homozygous mutation c.822_823insCTTTCAGG (p.Asp275LeufsX13) in the FANCL gene. The patient's clinical course was typical for FA with progression to bone marrow failure, and death from acute myelomonocytic leukemia (AML-M4) at 9 years of age. Mutation analysis also detected a likely somatic c.2608G > A (p.Gly870Ser) in the SETBP1 gene. Consistent copy number losses of 7q and 18p and gains of 3q and 21q and accumulated non-clonal single cell chromosomal abnormalities were detected in blood leukocytes as her FA progressed. This is the first Chinese FA-L case caused by a novel FANCL mutation. The somatic gene mutation and copy number aberrations could be used to monitor disease progression and the clinical findings provide further information for genotype-phenotype correlation for FA-L. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Corrective Action Decision Document/Closure Report for Corrective Action Unit 372: Area 20 Cabriolet/Palanquin Unit Craters, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Matthews, Patrick and Sloop, Christy

2011-04-01

This Corrective Action Decision Document (CADD)/Closure Report (CR) has been prepared for Corrective Action Unit (CAU) 372, Area 20 Cabriolet/Palanquin Unit Craters, located within Areas 18 and 20 at the Nevada National Security Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit 372 comprises four corrective action sites (CASs): • 18-45-02, Little Feller I Surface Crater • 18-45-03, Little Feller II Surface Crater • 20-23-01, U-20k Contamination Area • 20-45-01, U-20L Crater (Cabriolet) The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 372 based on the implementation of the corrective action of closure in place with administrative controls at all CASs. Corrective action investigation (CAI) activities were performed from November 9, 2009, through December 10, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 372: Area 20 Cabriolet/Palanquin Unit Craters. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 372 dataset of investigation results was evaluated based on a data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL was established of 25 millirem per year based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were found to be present at all four CASs. It is assumed that radionuclide levels present within the Little Feller I and Cabriolet high

Meio ambiente, Celso Furtado e o desenvolvimento como falácia The environment, Celso Furtado and development as a fallacy

Directory of Open Access Journals (Sweden)

Clóvis Cavalcanti

2003-01-01

Full Text Available O trabalho de Celso Furtado como pensador social é conhecido por suas enormes contribuições ao entendimento dos problemas do desenvolvimento no contexto dos países subdesenvolvidos. Sua teoria do subdesenvolvimentom, elaborada há quatro décadas, persiste como uma visão atual da realidade. Furtado repassa constantemente conceitos como o de dependência, concentração de renda, mimetismo cultural, relações assimétrias centro-periferia, mercado interno e muitos outros, além de trabalhar uma visão estruturalista do subdesenvolvimento, do desenvolvimento e de fenômenos correlatos. No livro O Mito do Desenvolvimento ele levanta duas questões não comuns ao restante da sua obra. A primeira delas diz respeito aos impactos do processo econômico no meio físico, na natureza _ um tema completamente alheio ao núcleo do pensamento tradicional da ciência da economia . A segunda se refere à constatação do caráter de mito moderno do desenvolvimento econômico. Que Furtado tenha feito isso em 1974, época do Milagre, demonstra o vigor de seu pensamento visionário. Vale a pena voltar ao assunto. É o que se faz no artigo.The work of Celso Furtado as a social thinker is known because of its great contribution to understanding development issues in the context of underdeveloped countries. His theory of underdevelopment, conceived four decades ago, persists as a current vision of reality. Furtado constantly re-examines concepts such as dependency, income concentration, cultural mimetism, asymmetric relations between center and periphery, internal market and many others, in addition to working with a structuralist vision of underdevelopment, development and related phenomena. In his book The Myth of Development, he raises two questions which are not common in the rest of his work. The first deals with the impact of the economic process on the physical medium, on nature _ a subject that is completely strange to the core of traditional thought of

Control of cyclin C levels during development of Dictyostelium.

Directory of Open Access Journals (Sweden)

David M Greene

2010-05-01

Full Text Available Cdk8 and its partner cyclin C form part of the mediator complex which links the basal transcription machinery to regulatory proteins. The pair are required for correct regulation of a subset of genes and have been implicated in control of development in a number of organisms including the social amoeba Dictyostelium discoideum. When feeding, Dictyostelium amoebae are unicellular but upon starvation they aggregate to form a multicellular structure which develops into a fruiting body containing spores. Cells in which the gene encoding Cdk8 has been deleted fail to enter aggregates due to a failure of early gene expression.We have monitored the expression levels of cyclin C protein during development and find levels decrease after the multicellular mound is formed. This decrease is triggered by extracellular cAMP that, in turn, is working in part through an increase in intracellular cAMP. The loss of cyclin C is coincident with a reduction in the association of Cdk8 with a high molecular weight complex in the nucleus. Overexpression of cyclin C and Cdk8 lead to an increased rate of early development, consistent with the levels being rate limiting.Overall these results show that both cyclin C and Cdk8 are regulated during development in response to extracellular signals and the levels of these proteins are important in controlling the timing of developmental processes. These findings have important implications for the role of these proteins in controlling development, suggesting that they are targets for developmental signals to regulate gene expression.

Determinants and Levels of Agricultural Development Agents Job ...

African Journals Online (AJOL)

This study was conducted with an objective of assessing the level of job satisfaction and its determinants among agricultural development agents working in different kebeles of Kalu Woreda, South Wollo Zone of the Amhara National Regional State. A total of 100 development agents were selected and interviewed using ...

Phenotype of transgenic mice carrying a very low copy number of the mutant human G93A superoxide dismutase-1 gene associated with amyotrophic lateral sclerosis.

Directory of Open Access Journals (Sweden)

Jeffrey S Deitch

Full Text Available Amyotrophic lateral sclerosis (ALS is a progressive neurodegenerative disease of the motor neuron. While most cases of ALS are sporadic, 10% are familial (FALS with 20% of FALS caused by a mutation in the gene that codes for the enzyme Cu/Zn superoxide dismutase (SOD1. There is variability in sporadic ALS as well as FALS where even within the same family some siblings with the same mutation do not manifest disease. A transgenic (Tg mouse model of FALS containing 25 copies of the mutant human SOD1 gene demonstrates motor neuron pathology and progressive weakness similar to ALS patients, leading to death at approximately 130 days. The onset of symptoms and survival of these transgenic mice are directly related to the number of copies of the mutant gene. We report the phenotype of a very low expressing (VLE G93A SOD1 Tg carrying only 4 copies of the mutant G93ASOD1 gene. While weakness can start at 9 months, only 74% of mice 18 months or older demonstrate disease. The VLE mice show decreased motor neurons compared to wild-type mice as well as increased cytoplasmic translocation of TDP-43. In contrast to the standard G93A SOD1 Tg mouse which always develops motor weakness leading to death, not all VLE animals manifested clinical disease or shortened life span. In fact, approximately 20% of mice older than 24 months had no motor symptoms and only 18% of VLE mice older than 22 months reached end stage. Given the variable penetrance of clinical phenotype, prolonged survival, and protracted loss of motor neurons the VLE mouse provides a new tool that closely mimics human ALS. This tool will allow the study of pathologic events over time as well as the study of genetic and environmental modifiers that may not be causative, but can exacerbate or accelerate motor neuron disease.

Magneto-Elastic behaviour of Steels for Naval Applications

Science.gov (United States)

1991-02-01

test specimens to be inserted. The specimens are preferably long and thin to avoid demagnetization effects, but are also preferably short and squat ...jr.".-.IC’’" ?!o w:.I ,,od ntt’pcrtJ B15 q12 fA-l spc +icob are as ’l . The stress level was -200l MIa for the Dt l((Td) ’ process, and ranged from 0

Failure to wean caused by cryptogenic fibrosing pleuritis and bilateral lung trapping: case report Falência do desmame em paciente com fibrose pleural idiopática e trapping pulmonar bilateral: relato de caso

Directory of Open Access Journals (Sweden)

Elsemiek Verweel

2007-12-01

Full Text Available BACKGROUND AND OBJECTIVES: Cryptogenic fibrosing pleuritis is an extremely rare disease, which can affect both lungs from a very young age. The most common finding is severe lung restriction resulting in both hypoxemic and ventilatory failure. CASE REPORT: Male patient, 26 year old with acute deterioration of chronic respiratory failure. Following admission prolonged mechanical ventilation was necessary. An atypical clinical presentation made the diagnosis difficult, but eventually cryptogenic fibrosing pleuritis and lung fibrosis were established. CONCLUSIONS: The prognostic outcome of patients with the final diagnosis of cryptogenic fibrosing pleuritis is extremely poor, especially in an advanced phase of this disease. We recommend early treatment with corticosteroids or surgical pleural decortication.JUSTIFICATIVA E OBJETIVOS: Fibrose pleural idiopática é uma doença rara e pode afetar ambos pulmões já desde uma idade precoce. O achado mais comum na fibrose pleural idiopática é uma restrição pulmonar grave que pode levar a um quadro de falência respiratória e hipoxemia. RELATO DO CASO: Paciente do sexo masculino, 26 anos, internado com reagudização de insuficiência respiratória crônica e submetido à ventilação mecânica prolongada. Após intensa investigação e uma apresentação clínica atípica, foi estabelecido o diagnóstico de fibrose pleural idiopática associado à fibrose pulmonar. CONCLUSÕES: O prognóstico de pacientes com fibrose pleural idiopática é extremamente ruim, particularmente em fase avançada da doença. Recomenda-se o tratamento precoce com corticosteróides ou decorticação pleural cirúrgica.

Developing State Level Approaches under the State Level Concept

International Nuclear Information System (INIS)

Budlong Sylvester, K.; Murphy, C.L.; Boyer, B.; Pilat, J.F.

2015-01-01

With the pursuit of the State-Level Concept (SLC), the IAEA has sought to further evolve the international safeguards system in a manner which maintains (or improves) the effectiveness of the system in an environment of expanding demands and limited resources. The IAEA must not remain static and should continuously examine its practices to ensure it can capture opportunities for cost reductions while adapting to, and staying ahead of, emerging proliferation challenges. Contemporary safeguards have been focused on assessing the nuclear programme of the State as a whole, rather than on the basis of individual facilities. Since the IAEA's integrated safeguards program, State-level Approaches (SLAs) have been developed that seek to optimally combine the measures provided for by the Additional Protocol with those of traditional safeguards. This process resulted in facility specific approaches that, while making use of a State's broader conclusion, were nonetheless prescriptive. Designing SLAs on a State-by-State basis would avoid the shortcomings of a one-size-fits-all system. It would also enable the effective use of the Agency's information analysis and State evaluation efforts by linking this analysis to safeguards planning efforts. Acquisition Path Analysis (APA), along with the State Evaluation process, can be used to prioritize paths in a State in terms of their attractiveness for proliferation. While taking advantage of all safeguards relevant information, and tailoring safeguards to individual characteristics of the State, paths of the highest priority in all States will necessarily meet the same standard of coverage. Similarly, lower priority paths will have lower performance targets, thereby promoting nondiscrimination. Such an approach would improve understanding of safeguards implementation under the SLC and the rational for safeguards resource allocation. The potential roles for APA and performance targets in SLA development will be reviewed

Influence Factors of the Economic Development Level Across European Countries

OpenAIRE

Diana Ioana POPA

2016-01-01

The economic development level of a country refers to the measure of the progress in an economy that could be measured, especially through GDP or GDP per capita. The level of these indicators can be influenced by many factors as a large scale, from social and economical to environmental and government policies factors. The paper aims to investigate some of these influence factors of the economic development level, represented in this case by GDP per capita, across European countries in the...

Development of low weight self-levelling mortars

International Nuclear Information System (INIS)

Padilla, A; Panama, I; Toledo, A; Flores, A

2015-01-01

This work shows the development of self levelling mortars, using micro bubbles based on aluminium silicate with a density of 0.25 g/cm 3 . Mortars formulations are composed by 8 different components in order to achieve properties balance between fresh and solid state. The mean objective is development light weight mortars with high fluidity and compression strength using micro bubbles and some additives. Formulations were designed employing Taguchi DOE of 8 variables and 3 states. Result analysis according to Taguchi method lets indentify the preponderant effect of each variable on the cited properties. Several formulations reached fluidity higher than 250%, with compression strength around 100 kg/cm 2 and a low volumetric weigh. Obtained volumetric weights are 20% less than commercial self levelling mortars weight. Finally some relations are presented such: as relation water/cement with fluidity, and micro bubble content versus mortars volumetric weight, and finally compression strength versus the volumetric weight of mortars

Recent Developments in Level 2 PSA and Severe Accident Management

International Nuclear Information System (INIS)

Ang, Ming Leang; Shepherd, Charles; Gauntt, Randall; Landgren, Vickie; Van Dorsselaere, Jean Pierre; Chaumont, Bernard; Raimond, Emmanuel; Magallon, Daniel; Prior, Robert; Mlady, Ondrej; Khatib-Rahbar, Mohsen; Lajtha, Gabor; Tinkler, Charles; Siu, Nathan

2007-01-01

In 1997, CSNI WGRISK produced a report on the state of the art in Level 2 PSA and severe accident management - NEA/CSNI/R(1997)11. Since then, there have been significant developments in that more Level 2 PSAs have been carried out worldwide for a variety of nuclear power plant designs including some that were not addressed in the original report. In addition, there is now a better understanding of the severe accident phenomena that can occur following core damage and the way that they should be modelled in the PSA. As requested by CSNI in December 2005, the objective of this study was to produce a report that updates the original report and gives an account of the developments that have taken place since 1997. The aim has been to capture the most significant new developments that have occurred rather than to provide a full update of the original report, most of which is still valid. This report is organised using the same structure as the original report as follows: Chapter 2: Summary on state of application, results and insights from recent Level 2 PSAs. Chapter 3: Discussion on key severe accident phenomena and modelling issues, identification of severe accident issues that should be treated in Level 2 PSAs for accident management applications, review of severe accident computer codes and the use of these codes in Level 2 PSAs. Chapter 4: Review of approaches and practices for accident management and SAM, evaluation of actions in Level 2 PSAs. Chapter 5: Review of available Level 2 PSA methodologies, including accident progression event tree / containment event tree development. Chapter 6: Aspects important to quantification, including the use of expert judgement and treatment of uncertainties. Chapter 7: Examples of the use of the results and insights from the Level 2 PSA in the context of an integrated (risk informed) decision making process

Editorial

Directory of Open Access Journals (Sweden)

Reinaldo Giraldo Díaz

2014-05-01

Full Text Available Para esta editorial de RIAA hemos querido rendir homenaje a uno de los más importantes investigadores colombianos: Orlando Fals Borda, sociólogo. Para ello, presentamos apartes de algunas lecturas de sus textos y lo presentamos como una provocación para retomar una de las preguntas que planteaba Fals Borda: "¿qué exigencias nos ha hecho y nos hace la realidad en cuanto a nuestro papel como científicos y en cuanto a nuestra concepción y utilización de la ciencia?"

Aspect-Oriented Model Development at Different Levels of Abstraction

NARCIS (Netherlands)

Alférez, Mauricio; Amálio, Nuno; Ciraci, S.; Fleurey, Franck; Kienzle, Jörg; Klein, Jacques; Kramer, Max; Mosser, Sebastien; Mussbacher, Gunter; Roubtsova, Ella; Zhang, Gefei; France, Robert B.; Kuester, Jochen M.; Bordbar, Behzad; Paige, Richard F.

2011-01-01

The last decade has seen the development of diverse aspect- oriented modeling (AOM) approaches. This paper presents eight different AOM approaches that produce models at different level of abstraction. The approaches are different with respect to the phases of the development lifecycle they target,

Standing operating procedures for developing acute exposure guideline levels for hazardous chemicals

National Research Council Canada - National Science Library

National Research Council (U.S.). Subcommittee on Acute Exposure Guideline Levels

2001-01-01

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs...

Space Mission Concept Development Using Concept Maturity Levels

Science.gov (United States)

Wessen, Randii R.; Borden, Chester; Ziemer, John; Kwok, Johnny

2013-01-01

Over the past five years, pre-project formulation experts at the Jet Propulsion Laboratory (JPL) has developed and implemented a method for measuring and communicating the maturity of space mission concepts. Mission concept development teams use this method, and associated tools, prior to concepts entering their Formulation Phases (Phase A/B). The organizing structure is Concept Maturity Level (CML), which is a classification system for characterizing the various levels of a concept's maturity. The key strength of CMLs is the ability to evolve mission concepts guided by an incremental set of assessment needs. The CML definitions have been expanded into a matrix form to identify the breadth and depth of analysis needed for a concept to reach a specific level of maturity. This matrix enables improved assessment and communication by addressing the fundamental dimensions (e.g., science objectives, mission design, technical risk, project organization, cost, export compliance, etc.) associated with mission concept evolution. JPL's collaborative engineering, dedicated concept development, and proposal teams all use these and other CML-appropriate design tools to advance their mission concept designs. This paper focuses on mission concept's early Pre-Phase A represented by CMLs 1- 4. The scope was limited due to the fact that CMLs 5 and 6 are already well defined based on the requirements documented in specific Announcement of Opportunities (AO) and Concept Study Report (CSR) guidelines, respectively, for competitive missions; and by NASA's Procedural Requirements NPR 7120.5E document for Projects in their Formulation Phase.

Closure Report for Corrective Action Unit 574: Neptune, Nevada National Security Site, Nevada

International Nuclear Information System (INIS)

2012-01-01

Corrective Action Unit (CAU) 574 is identified in the Federal Facility Agreement and Consent Order (FFACO) as 'Neptune' and consists of the following two Corrective Action Sites (CASs), located in Area 12 of the Nevada National Security Site: (1) CAS 12-23-10, U12c.03 Crater (Neptune); and (2) CAS 12-45-01, U12e.05 Crater (Blanca). This Closure Report presents information supporting closure of CAU 574 according to the FFACO (FFACO, 1996 [as amended March 2010]) and the Streamlined Approach for Environmental Restoration Plan for CAU 574 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSA/NSO], 2011). The following activities were performed to support closure of CAU 574: (1) In situ external dose rate measurements were collected using thermoluminescent dosimeters at CAS 12-45-01, U12e.05 Crater (Blanca). (2) Total effective dose rates were determined at both sites by summing the internal and external dose rate components. (3) A use restriction (UR) was implemented at CAS 12-23-10, U12c.03 Crater (Neptune). Areas that exceed the final action level (FAL) of 25 millirems per year (mrem/yr) based on the Occasional Use Area exposure scenario are within the existing use restricted area for CAU 551. The 25-mrem/yr FAL is not exceeded outside the existing CAU 551 UR for any of the exposure scenarios (Industrial Area, Remote Work Area, and Occasional Use Area). Therefore, the existing UR for CAU 551 is sufficient to bound contamination that exceeds the FAL. (4) An administrative UR was implemented at CAS 12-45-01, U12e.05 Crater (Blanca) as a best management practice (BMP). The 25-mrem/yr FAL was not exceeded for the Remote Work Area or Occasional Use Area exposure scenarios; therefore, a UR is not required. However, because the 25-mrem/yr FAL was exceeded for the Industrial Area exposure scenario, an administrative UR was established as a BMP. UR documentation is included as Appendix B. The UR at CAS 12-23-10, U12c.03 Crater (Neptune

Aluminium-27 n.m.r. studies of aluminium fluoro complexes in dichloromethane solution: evidence for tetrafluoroaluminate anion

International Nuclear Information System (INIS)

Colton, R.; Eller, P.G.

1989-01-01

Mixed aluminium chloro/fluoro anions are formed in dichloromethane solution by the interaction of AlCl 3 and [Ph 3 PhCH 2 P] [H 2 F 3 ]. Aluminium-27 n.m.r. studies are restricted to the stoichiometric ranges F/Al from 1:1 to 3:1 and F/Al>8:1. Between these limits rapid precipitation reactions occur. In the fluoride-rich stoichiometric range there is rapid exchange on the n.m.r. time scale between the aluminium fluoro anion and free fluoride, so that a direct identification of the species by the multiplicity of the resonance is not possible. Indirect evidence strongly suggests that the aluminium species is [AlF 4 ] - . In the F/Al stoichiometry range from 1:1 to 3:1 aluminium-27 resonances were observed for all the other possible [AlCl χ F 4-χ ] - species. Studies on the aluminium iodo/fluoro system support the identification of [AlF 4 ] - , but the system is labile and the mixed iodo/fluoro species undergo rapid disproportionation. 12 refs., 1 fig

Use of global assays to understand clinical phenotype in congenital factor VII deficiency.

Science.gov (United States)

Greene, L A; Goldenberg, N A; Simpson, M L; Villalobos-Menuey, E; Bombardier, C; Acharya, S S; Santiago-Borrero, P J; Cambara, A; DiMichele, D M

2013-09-01

Congenital factor VII (FVII) deficiency is characterized by genotypic variability and phenotypic heterogeneity. Traditional screening and factor assays are unable to reliably predict clinical bleeding phenotype and guide haemorrhage prevention strategy. Global assays of coagulation and fibrinolysis may better characterize overall haemostatic balance and aid in haemorrhagic risk assessment. We evaluated the ability of novel global assays to better understand clinical bleeding severity in congenital FVII deficiency. Subjects underwent central determination of factor VII activity (FVII:C) as well as clot formation and lysis (CloFAL) and simultaneous thrombin and plasmin generation (STP) global assay analysis. A bleeding score was assigned to each subject through medical chart review. Global assay parameters were analysed with respect to bleeding score and FVII:C. Subgroup analyses were performed on paediatric subjects and subjects with FVII ≥ 1 IU dL(-1). CloFAL fibrinolytic index (FI2 ) inversely correlated with FVII:C while CloFAL maximum amplitude (MA) and STP maximum velocity of thrombin generation (VT max) varied directly with FVII:C. CloFAL FI2 directly correlated with bleeding score among subjects in both the total cohort and paediatric subcohort, but not among subjects with FVII ≥ 1 IU dL(-1) . Among subjects with FVII ≥ 1 IU dL(-1), STP time to maximum velocity of thrombin generation and time to maximum velocity of plasmin generation inversely correlated with bleeding score. These preliminary findings suggest a novel potential link between a hyperfibrinolytic state in bleeding severity and congenital FVII deficiency, an observation that should be further explored. © 2013 John Wiley & Sons Ltd.

Concept development for saltstone and low level waste disposal

International Nuclear Information System (INIS)

Wilhite, E.L.

1987-03-01

A low-level alkaline salt solution will be a byproduct in the processing of high-level waste at the Savannah River Plant (SRP). This solution will be incorporated into a cement wasteform, saltstone, and placed in surface vaults. Laboratory and field testing and mathematical modeling have demonstrated the predictability of contaminant release from cement wasteforms. Saltstone disposal in surface vaults will meet drinking water standards in shallow groundwater at the disposal area boundary. Planning for new Low-Level Waste (LLW) disposal could incorporate concepts developed for saltstone disposal

Integration of multi-level marketing management systems geographically industry development

OpenAIRE

Aleksandr Lavrov; Lada Polikarpova; Alla Handramai

2015-01-01

In the article the authors attempt to develop a multi-level management system territorially industry development in market conditions, built in the widespread use of various types of marketing and their horizontal and vertical integration.

Practical considerations in the development and application of reference levels

International Nuclear Information System (INIS)

Selby, J. M.; Kennedy, W. E. Jr.; Swinth, K. L.; Gilbert, R. O.; Soldat, J. K.

1988-05-01

Radiological exposures to the public during an accident that releases radioactive materials to the environment occur initially through the air pathway, secondly through a water pathway, and finally, through the food chain. From these exposure pathways, reference levels of radionuclides must be applied to limit public radiation doses. Such reference levels are difficult to develop and apply, particularly if the contaminants are transuranic elements such as plutonium. The reference level must be related to a resultant theoretical dose to the public through generic calculations. However, to permit rapid decisions after an accident, the reference levels need to be related to conditions or media in the environment that can be directly measured. They must also be tied to specific countermeasures such as sheltering, evacuation, or interdiction of drinking water or food supplies. This paper discusses the practical considerations in the development and application of reference levels for transuranic in the environment and the present capability to rapidly detect and quantify their concentrations following accidental contamination events. 16 refs., 3 tabs

Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis.

Science.gov (United States)

Kabashi, Edor; Agar, Jeffrey N; Taylor, David M; Minotti, Sandra; Durham, Heather D

2004-06-01

Mutations in the Cu/Zn-superoxide dismutase (SOD-1) gene are responsible for a familial form of amyotrophic lateral sclerosis (fALS). The present study demonstrated impaired proteasomal function in the lumbar spinal cord of transgenic mice expressing human SOD-1 with the ALS-causing mutation G93A (SOD-1(G93A)) compared to non-transgenic littermates (LM) and SOD-1(WT) transgenic mice. Chymotrypsin-like activity was decreased as early as 45 days of age. By 75 days, chymotrypsin-, trypsin-, and caspase-like activities of the proteasome were impaired, at about 50% of control activity in lumbar spinal cord, but unchanged in thoracic spinal cord and liver. Both total and specific activities of the proteasome were reduced to a similar extent, indicating that a change in proteasome function, rather than a decrease in proteasome levels, had occurred. Similar decreases of total and specific activities of the proteasome were observed in NIH 3T3 cell lines expressing fALS mutants SOD-1(G93A) and SOD-1(G41S), but not in SOD-1(WT) controls. Although overall levels of proteasome were maintained in spinal cord of SOD-1(G93A) transgenic mice, the level of 20S proteasome was substantially reduced in lumbar spinal motor neurons relative to the surrounding neuropil. It is concluded that impairment of the proteasome is an early event and contributes to ALS pathogenesis.

High-level Component Interfaces for Collaborative Development: A Proposal

Directory of Open Access Journals (Sweden)

Thomas Marlowe

2009-12-01

Full Text Available Software development has rapidly moved toward collaborative development models where multiple partners collaborate in creating and evolving software intensive systems or components of sophisticated ubiquitous socio-technical-ecosystems. In this paper we extend the concept of software interface to a flexible high-level interface as means for accommodating change and localizing, controlling and managing the exchange of knowledge and functional, behavioral, quality, project and business related information between the partners and between the developed components.

Evaluating the Development Levels of Rural Areas in Koohrang County

Directory of Open Access Journals (Sweden)

saleh shahrokhi sardo

2016-02-01

Full Text Available A better understanding of geographical phenomena and scientific comprehending of geographical locations requires comprehensive information about these areas. In addition, the awareness of the spatial distribution and development levels are considered as prerequisites for rural development plans and programs. Therefore, the aim of this study was to evaluate the development levels of rural areas in Koohrang County. Statistical population was over ten households selected among rural areas (132 villages in Koohrang County. The required secondary data were collected and designed from the statistical yearbook of Koohrang County in 2011. In this study, a combination method of VIKOR-AHP was used to measure level of development in the villages. In addition, in order to determine the optimal distribution of indices, the Gini coefficient was used. Data processing was conducted using MATLAB7.10 and Expert Choice software. Results showed that the highest and lowest degrees of development (0.994 and 0.005 were related to "Castle of Ali-Abad" and "Dezak-Cheshmeh" villages, respectively. Moreover, results indicated that there was the unfavorable development in the study area (with average of 0. 217 in the range 0-1 in a way that most of the villages (21.46% with 53.39% of the population in the area were completely undeveloped. Furthermore, the results based on Gini coefficient and coefficient of variability revealed that the conventional indices of rural development weren't distributed properly. Therefore, it is necessary to have special review and reconsider to determine the main service centers based on settlements hierarchical system.

Development Situation, Trend and Countermeasure of Consumer-level UAV Market in China

Directory of Open Access Journals (Sweden)

Kang Yu-Lei

2017-01-01

Full Text Available This paper is based on the status of Chinese consumer-level UAV(Unmanned Aerial Vehicle market. According to the main problems in Chinese consumer-level UAV market, the author analyses the trends of Chinese consumer-level UAV market. Then, the author put forward some suggestions to develop Chinese consumer-level UAV market. In 21st century, the research and development expenditure presents the explosive growth in Chinese consumer-level UAV market. From the year of 2012, DJI released their first consumer-level UAV product. Amazon, Facebook, Google and other companies have announced their entry into the UAV market. In 2016, Huawei also announced that it will enter the UAV market.

Corrective Action Decision Document for Corrective Action Unit 563: Septic Systems, Nevada Test Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Grant Evenson

2008-02-01

This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 563, Septic Systems, in accordance with the Federal Facility Agreement and Consent Order (FFACO, 1996; as amended January 2007). The corrective action sites (CASs) for CAU 563 are located in Areas 3 and 12 of the Nevada Test Site, Nevada, and are comprised of the following four sites: •03-04-02, Area 3 Subdock Septic Tank •03-59-05, Area 3 Subdock Cesspool •12-59-01, Drilling/Welding Shop Septic Tanks •12-60-01, Drilling/Welding Shop Outfalls The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative (CAA) for the four CASs within CAU 563. Corrective action investigation (CAI) activities were performed from July 17 through November 19, 2007, as set forth in the CAU 563 Corrective Action Investigation Plan (NNSA/NSO, 2007). Analytes detected during the CAI were evaluated against appropriate final action levels (FALs) to identify the contaminants of concern (COCs) for each CAS. The results of the CAI identified COCs at one of the four CASs in CAU 563 and required the evaluation of CAAs. Assessment of the data generated from investigation activities conducted at CAU 563 revealed the following: •CASs 03-04-02, 03-59-05, and 12-60-01 do not contain contamination at concentrations exceeding the FALs. •CAS 12-59-01 contains arsenic and chromium contamination above FALs in surface and near-surface soils surrounding a stained location within the site. Based on the evaluation of analytical data from the CAI, review of future and current operations at CAS 12-59-01, and the detailed and comparative analysis of the potential CAAs, the following corrective actions are recommended for CAU 563.

Application of biomarkers to assess the condition of European Marine Sites

Energy Technology Data Exchange (ETDEWEB)

Hagger, Josephine A., E-mail: j.hagger@exeter.ac.u [School of Biosciences, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS (United Kingdom); Galloway, Tamara S. [School of Biosciences, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS (United Kingdom); Langston, William J. [Marine Biological Association, Citadel Hill, Plymouth PL1 2PB, Devon (United Kingdom); Jones, Malcolm B. [School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, Devon (United Kingdom)

2009-07-15

A series of European Marine Sites has been designated as Special Areas of Conservation (SAC) in England. The aim of this study was to develop a practical methodology to assess the condition of SACs by applying a suite of biomarkers. Biomarkers were applied to the blue mussel Mytilus edulis and the shore crab Carcinus maenas from the Fal and Helford SAC (Cornwall). Individual biomarkers provided useful diagnostic information on the activity of certain classes of contaminants and an integrated Biomarker Response Index (BRI) was used to achieve a more holistic understanding of the condition of the SAC. The BRI indicated that the general health of both organisms was impacted in the upper part of the SAC (Fal Estuary) which correlated well with known chemical hotspots and sources of contamination. The BRI allows a pragmatic way to prioritise SAC sites that may require further investigative studies. - A suite of biomarkers was successfully used to create a Biomarker Response Index to assess the health of aquatic organisms from European Marine Sites.

Application of biomarkers to assess the condition of European Marine Sites

International Nuclear Information System (INIS)

Hagger, Josephine A.; Galloway, Tamara S.; Langston, William J.; Jones, Malcolm B.

2009-01-01

A series of European Marine Sites has been designated as Special Areas of Conservation (SAC) in England. The aim of this study was to develop a practical methodology to assess the condition of SACs by applying a suite of biomarkers. Biomarkers were applied to the blue mussel Mytilus edulis and the shore crab Carcinus maenas from the Fal and Helford SAC (Cornwall). Individual biomarkers provided useful diagnostic information on the activity of certain classes of contaminants and an integrated Biomarker Response Index (BRI) was used to achieve a more holistic understanding of the condition of the SAC. The BRI indicated that the general health of both organisms was impacted in the upper part of the SAC (Fal Estuary) which correlated well with known chemical hotspots and sources of contamination. The BRI allows a pragmatic way to prioritise SAC sites that may require further investigative studies. - A suite of biomarkers was successfully used to create a Biomarker Response Index to assess the health of aquatic organisms from European Marine Sites.

Development of a pressurizer level compensator for use on N Reactor

International Nuclear Information System (INIS)

Bussell, J.H.

1985-07-01

The instrument described in this report has been developed to compensate the measured water level in the N Reactor pressurizer for temperature effects. N Reactor is a pressurized water nuclear reactor (PWR). The instrument is defined as a pressurizer level compensator (PLC). A pressurizer is used in a PWR to control the primary coolant pressure and provide a surge volume for primary coolant expansion and contraction. A means of compensating for water and steam density is required because of the wide range of pressure and temperature that result from different steady state and transient reactor power levels. The uncompensated level is determined by measurement of differential pressure between the top of the level measurement zone and the bottom of the level measurement zone. Temperature of the water in the pressurizer is the parameter that is used to determine the proper level compensation since water and steam density are primarily functions of temperature in this case. The PLC uses a microprocessor to calculate the compensated level from temperature and differential pressure measurements. This report includes a description of the design, development, and implementation of software and hardware that are in the PLC. 9 refs., 51 figs., 17 tabs

Perceived Effectiveness of Professional Development Programs of Teachers at Higher Education Level

Science.gov (United States)

Malik, Sufiana Khatoon; Nasim, Uzma; Tabassum, Farkhanda

2015-01-01

The major purpose of the study was to assess the perceived effectiveness of professional development programs of teachers at higher educational level. The objectives of the study were: "to assess university level teachers'" opinion about effectiveness of professional development training with reference to quality teaching, to measure…

Glucose and Fructose to Platform Chemicals: Understanding the Thermodynamic Landscapes of Acid-Catalysed Reactions Using High-Level ab Initio Methods

Energy Technology Data Exchange (ETDEWEB)

Assary, Rajeev S.; Kim, Taijin; Low, John; Greeley, Jeffrey P.; Curtiss, Larry A.

2012-12-28

Molecular level understanding of acid-catalysed conversion of sugar molecules to platform chemicals such as hydroxy-methyl furfural (HMF), furfuryl alcohol (FAL), and levulinic acid (LA) is essential for efficient biomass conversion. In this paper, the high-level G4MP2 method along with the SMD solvation model is employed to understand detailed reaction energetics of the acid-catalysed decomposition of glucose and fructose to HMF. Based on protonation free energies of various hydroxyl groups of the sugar molecule, the relative reactivity of gluco-pyranose, fructo-pyranose and fructo-furanose are predicted. Calculations suggest that, in addition to the protonated intermediates, a solvent assisted dehydration of one of the fructo-furanosyl intermediates is a competing mechanism, indicating the possibility of multiple reaction pathways for fructose to HMF conversion in aqueous acidic medium. Two reaction pathways were explored to understand the thermodynamics of glucose to HMF; the first one is initiated by the protonation of a C2–OH group and the second one through an enolate intermediate involving acyclic intermediates. Additionally, a pathway is proposed for the formation of furfuryl alcohol from glucose initiated by the protonation of a C2–OH position, which includes a C–C bond cleavage, and the formation of formic acid. The detailed free energy landscapes predicted in this study can be used as benchmarks for further exploring the sugar decomposition reactions, prediction of possible intermediates, and finally designing improved catalysts for biomass conversion chemistry in the future.

Influence Factors of the Economic Development Level Across European Countries

Directory of Open Access Journals (Sweden)

Diana Ioana POPA

2016-06-01

Full Text Available The economic development level of a country refers to the measure of the progress in an economy that could be measured, especially through GDP or GDP per capita. The level of these indicators can be influenced by many factors as a large scale, from social and economical to environmental and government policies factors. The paper aims to investigate some of these influence factors of the economic development level, represented in this case by GDP per capita, across European countries in the context of the most recently crisis, named the Great Recession (2008 and after, when the economies are starting to recover (2013. Using linear regression in R (lm function, the goal is to explain the relationship between the interest variable (GDP per capita and certain independent variables. It is expected that even tough the estimators are to be different – as level – in both cases studied, the relationship type between them to be the same. The goodness of fit for the models used will be made based on ANOVA.

Contagion in the Brazilian interbank currency exchange market: an empirical analysis

Directory of Open Access Journals (Sweden)

Maria Tannuri-Pianto

2006-06-01

Full Text Available The risk of contagion is the possibility that the failure of a financial institution affected by an exogenous shock generates the failure of other institutions not initially affected by the shock. As pointed out by Upper and Worms (2002 and others, the domino effect in the payment system depends on the precise pattern of interbank linkages. This paper studies the occurrence of financial contagion after the exogenous failure of an institution authorized to operate in the Brazilian interbank currency market. The data contain information about all the actual transactions that occurred in this market from August 1st, 2000 to October 31st, 2002. The adopted methodology shows the occurrence of contagion propagation in several subsequent rounds after the initial failure. We quantify the number of institutions that breakdown and the financial losses of the market. There is a large increase in the number of failed institutions during the period of the presidential elections in 2002.O risco de contágio é a possibilidade de que a falência de uma instituição financeira afetada por algum choque exógeno gere a falência de outras instituições não afetadas pelo choque inicialmente. Como salienta Upper e Worms (2002 e outros, o efeito dominó no sistema de pagamentos depende do padrão das interligações bancárias. Este artigo estuda a ocorrência de contágio financeiro após a falência exógena de uma instituição autorizada a operar no mercado interbancário de câmbio no Brasil. Os dados contêm informações sobre todas as transações efetivamente realizadas no período 01/08/2000 a 31/10/2002. A metodologia adotada mostra a ocorrência da propagação do contágio após várias rodadas subseqüentes à falência inicial. O artigo quantifica o número de instituições que quebrariam e as perdas financeiras do mercado. Existe um aumento substancial no número de falências durante o período pré-eleitoral em 2002.

Development of cermets for high-level radioactive waste fixation

International Nuclear Information System (INIS)

Aaron, W.S.; Quinby, T.C.; Kobisk, E.H.

1979-01-01

A method is currently under development for the solidification and fixation of commercial and defense high-level radioactive wastes in the form of ceramic particles encapsulated by metal, i.e., a cermet. The chemical and physical processing techniques which have been developed and the properties of the resulting cermet bodies are described in this paper. These cermets have the advantages of high thermal conductivity and low leach rates

Biomonitoring of thallium availability in two estuaries of southwest England.

Science.gov (United States)

Turner, Andrew; Turner, Deborah; Braungardt, Charlotte

2013-04-15

Thallium is a highly toxic metal whose biogeochemical behaviour in the marine environment is poorly understood. We measured Tl in sediments, macroalgae (Fucus vesiculosus and Fucus ceranoides) and deposit-feeding invertebrates (Hediste diversicolor, Arenicola marina and Scrobicularia plana) from two estuaries of south west England (Plym and Fal) draining mineralised catchments. In the Plym, and for a given sample type, concentrations of Tl were rather invariant between sample locations and averaged about 500 μg kg(-1) for sediment, 30 μg kg(-1) for macroalgae and 10 μg kg(-1) for the invertebrates. In the Fal, respective concentrations were of a similar order of magnitude but exhibited greater variation between sample locations. Normalisation of Tl concentrations to K, the biogeochemical analogue of Tl(+), revealed bioenrichment of about 20 for all organisms in the Plym and bioenrichment ranging from about 3 (H. diversicolor) to 170 (F. ceranoides) in the Fal. Despite the low bioaccumulation of Tl relative to other metals measured concurrently, it is recommended that Tl be more closely monitored and better studied in the estuarine environment. Copyright © 2013 Elsevier Ltd. All rights reserved.

Fallible Knowledge

Directory of Open Access Journals (Sweden)

Rogério P. de Andrade

2009-06-01

Full Text Available O artigo discute a natureza do conhecimento em um ambiente sócio-econômico caracterizado por incerteza genuína. O ponto de partida é considerar que ambientes incertos tornam o conhecimento falível e contingente. O conhecimento é falível tanto em virtude de interações no espaço que acontecem ao mesmo tempo (complexidade, como devido à passagem do tempo. O artigo enfatiza dois tipos de conhecimento: “knowledge how” e “knowledge that”. O primeiro consiste em um tipo de conhecimento acerca do modo como fazemos algo e o segundo em um tipo de conhecimento acerca do porque fazemos algo. Uma forma que os agentes encontram para lidar com a condição de conhecimento falível é recorrer a convenções (Keynes e regras (Hayek. Convenções e regras são uma espécie de reservatório de uma forma de conhecimento social e intersubjetiva que os agentes podem adquirir, armazenar e comunicar uns com os outros. Elas fornecem em parte a informação necessária para o desempenho de suas atividades cotidianas.

Development of level 2 PSA technology

International Nuclear Information System (INIS)

Kim, Dong Ha; Park, Soo Yong; Kim, See Darl; Song, Yong Mann; Ahn, Kwang Il; Park, Jae Wu; Jin, Young Ho.

1997-07-01

The objective of this project is the development of the computer code system for level 2 probabilistic safety assessment (PSA) of nuclear power plants. The scope of the project can be divided into three areas. The first area is to develop the computer code (CONPAS) which can quantify the accident progression event trees. CONPAS beta version has been developed this year and it is comprised of four modules : 1) EDITOR for generating the event tree logic diagrams and 1) COMPUTER for event tree quantification and for additional use of the calculated results. 3) TEXT EDITOR and 4) CODE PLOTTER. Comparing with the existing computer code, the present code provides a flexible code reusability and user interface, convenient edition of logic diagram, data operation, and systematic quantification of the results. The methodology development of containment structural analysis is the second area. The specific tasks included the collection and analysis of the containment failure modes for the various containment types, and the methodology establishment for the containment structure analysis. Over twenty large dry PWR containments, the database for containment failure mode and pressure has been constructed and the simplified fragility model has been proposed to calculate the containment failure probability. They will be used as an important input not only in the containment analysis but also in the source term analysis. For the last, source term analyzing methodology and its applied computer code that is named as 'KORSOR' are developed. KORSOR which used parametric model approach combined modules which consist of accident sequence input module via user's logic rule, random sample generating module, parametric database module, and source term uncertainty quantification module. The characteristics of parametric data which use din the source term analyzing model is analyzed and the constructing idea and example for the parametric database is suggested. (author). 67 refs., 66 tabs

Defining Levels of Learning for Strengths Development Programs in Pharmacy

Directory of Open Access Journals (Sweden)

Kristin K. Janke, Ph.D.

2010-01-01

Full Text Available The Clifton StrengthsFinder® is an online measure of personal talent that identifies where an individual’s greatest potential for building strengths exists. This paper describes a framework for strengths education in pharmacy which includes introductory, intermediate and advanced levels of learning. The use of the StrengthsFinder® assessment and supporting workshops aids student pharmacists, pharmacy residents and practitioners in identifying and refining their talents and connecting talents to roles in the profession. Additional learning strategies support a learner’s progression to intermediate and advanced levels of learning, which focus on the application of strengths in teams, leadership, and organizational development. By articulating and recognizing levels of learning around strengths-related content and skills, strong instructional design is fostered. Optimal design includes development of a sequence of learning opportunities delivered over time, a roll-out plan and consideration of the instructional resources required.

Defining Levels of Learning for Strengths Development Programs in Pharmacy

Directory of Open Access Journals (Sweden)

Kristin Janke

2010-01-01

Full Text Available The Clifton StrengthsFinder™ is an online measure of personal talent that identifies where an individual's greatest potential for building strengths exists. This paper describes a framework for strengths education in pharmacy which includes introductory, intermediate and advanced levels of learning. The use of the StrengthsFinder™ assessment and supporting workshops aids student pharmacists, pharmacy residents and practitioners in identifying and refining their talents and connecting talents to roles in the profession. Additional learning strategies support a learner's progression to intermediate and advanced levels of learning, which focus on the application of strengths in teams, leadership, and organizational development. By articulating and recognizing levels of learning around strengths-related content and skills, strong instructional design is fostered. Optimal design includes development of a sequence of learning opportunities delivered over time, a roll-out plan and consideration of the instructional resources required. Type: Idea Paper

Company Level Commander Development In The US Army

Science.gov (United States)

2013-12-01

pedagogy and andragogy in instruction can have a significant positive impact on developing combat arms officers to be successful company level commanders...Recommendations to achieve these improvements using andragogy are discussed. In the United States (US) Army, when an officer...use Malcom Knowles’ andragogy framework for understanding adults as learners in order to analyze the trainees and maximize the training outcomes for

Development of melt compositions for sulphate bearing high level waste

International Nuclear Information System (INIS)

Jahagirdar, P.B.; Wattal, P.K.

1997-09-01

The report deals with the development and characterization of vitreous matrices for sulphate bearing high level waste. Studies were conducted in sodium borosilicate and lead borosilicate systems with the introduction of CaO, BaO, MgO etc. Lead borosilicate system was found to be compatible with sulphate bearing high level wastes. Detailed product evaluation carried on selected formulations is also described. (author)

Corrective Action Decision Document/Closure Report for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada National Security Site, Nevada with ROTC 1 and 2, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Matthews, Patrick

2011-07-01

Corrective Action Unit 374 comprises five corrective action sites (CASs): • 18-22-05, Drum • 18-22-06, Drums (20) • 18-22-08, Drum • 18-23-01, Danny Boy Contamination Area • 20-45-03, U-20u Crater (Schooner) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 374 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at CASs 18-23-01 and 20-45-03, and a corrective action of removing potential source material (PSM) was conducted at CAS 20-45-03. The other CASs require no further action; however, best management practices of removing PSM and drums at CAS 18-22-06, and removing drums at CAS 18-22-08 were performed. Corrective action investigation (CAI) activities were performed from May 4 through October 6, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada Test Site, Nevada. The approach for the CAI was divided into two facets: investigating the primary release of radionuclides and investigating other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 374 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were found to be present in the surface soil that was sampled. It is assumed that radionuclide levels present in subsurface media within the craters and ejecta fields (default contamination boundaries) at the Danny Boy and

Technology readiness levels for advanced nuclear fuels and materials development

Energy Technology Data Exchange (ETDEWEB)

Carmack, W.J., E-mail: jon.carmack@inl.gov [Idaho National Laboratory, Idaho Falls, ID (United States); Braase, L.A.; Wigeland, R.A. [Idaho National Laboratory, Idaho Falls, ID (United States); Todosow, M. [Brookhaven National Laboratory, Upton, NY (United States)

2017-03-15

Highlights: • Definition of nuclear fuels system technology readiness level. • Identification of evaluation criteria for nuclear fuel system TRLs. • Application of TRLs to fuel systems. - Abstract: The Technology Readiness process quantitatively assesses the maturity of a given technology. The National Aeronautics and Space Administration (NASA) pioneered the process in the 1980s to inform the development and deployment of new systems for space applications. The process was subsequently adopted by the Department of Defense (DoD) to develop and deploy new technology and systems for defense applications. It was also adopted by the Department of Energy (DOE) to evaluate the maturity of new technologies in major construction projects. Advanced nuclear fuels and materials development is needed to improve the performance and safety of current and advanced reactors, and ultimately close the nuclear fuel cycle. Because deployment of new nuclear fuel forms requires a lengthy and expensive research, development, and demonstration program, applying the assessment process to advanced fuel development is useful as a management, communication, and tracking tool. This article provides definition of technology readiness levels (TRLs) for nuclear fuel technology as well as selected examples regarding the methods by which TRLs are currently used to assess the maturity of nuclear fuels and materials under development in the DOE Fuel Cycle Research and Development (FCRD) Program within the Advanced Fuels Campaign (AFC).

Development of a test system for high level liquid waste partitioning

Directory of Open Access Journals (Sweden)

Duan Wu H.

2015-01-01

Full Text Available The partitioning and transmutation strategy has increasingly attracted interest for the safe treatment and disposal of high level liquid waste, in which the partitioning of high level liquid waste is one of the critical technical issues. An improved total partitioning process, including a tri-alkylphosphine oxide process for the removal of actinides, a crown ether strontium extraction process for the removal of strontium, and a calixcrown ether cesium extraction process for the removal of cesium, has been developed to treat Chinese high level liquid waste. A test system containing 72-stage 10-mm-diam annular centrifugal contactors, a remote sampling system, a rotor speed acquisition-monitoring system, a feeding system, and a video camera-surveillance system was successfully developed to carry out the hot test for verifying the improved total partitioning process. The test system has been successfully used in a 160 hour hot test using genuine high level liquid waste. During the hot test, the test system was stable, which demonstrated it was reliable for the hot test of the high level liquid waste partitioning.

Development of threshold guidance: National Low-Level Radioactive Waste Management Program

International Nuclear Information System (INIS)

1986-09-01

The current study has been conducted to provide DOE with a technical basis for the development of threshold guidance. The objective of the study was to develop the necessary background information and recommendations to assist the DOE in implementing the threshold limit concept for the disposal of DOE wastes at DOE facilities. The nature of low-level radioactive waste (LLW) varies greatly in both form and radionuclide content. While some low-level waste streams can contain substantial quantities of radioactive constituents, a potentially significant fraction of low-level waste is contaminated either very slightly or not at all. There is a strong likelihood that managing wastes with extremely low levels of radioactivity as nonradioactive waste would pose no significant safety problems and could result in substantial cost savings relative to its handling as LLW. Since all materials, including waste products, contain some radioactivity, it is necessary to distinguish between those wastes that would require disposal as LLW and those that have sufficiently low levels of radiological content to be managed according to their nonradiological properties. 131 refs., 9 figs., 24 tabs

Study on the development of safety regulations for geological disposal of high-level radioactive waste

International Nuclear Information System (INIS)

Wei Fangxin

2012-01-01

The development of regulations under Regulations on Safety Management of Radioactive Waste has become necessary as the issuance of it. The regulations related to geological disposal of high-level radioactive waste can promote the progress of research and development on geological disposal of high-level radioactive waste in China. This paper has present suggestions on development of regulations on geological disposal of high-level radioactive waste by analyzing development of safety regulations on geological disposal of high-level radioactive waste in foreign countries and problems occurred in China and discussed important issues related to the development of safety regulations on geological disposal of high-level radioactive waste. (author)

The Levels of Leadership and Transcendent Servant Leadership Development

Science.gov (United States)

McClellan, Jeffrey L.

2009-01-01

This paper addresses the challenges associated with defining and conceptualizing leadership amidst the plethora of theoretical constructs and definitions of leadership and proposes a model for developing transcendent servant-leaders. Based on a review of the literature, three categorical levels of leadership are outlined and discussed that…

Data base system for research and development of high-level waste conditioning

International Nuclear Information System (INIS)

Masaki, Toshio; Igarashi, Hiroshi; Ohuchi, Jin; Miyauchi, Tomoko.

1992-01-01

Results of research and development for High-Level Waste Conditioning are accumulated as large number of documents. Data Base System for Research and Development of High-Level Waste Conditioning has been developed since 1987 to search for necessary informations correctly and rapidly with the intention of offering and transferring the results to organization inside and outside of PNC. This data base system has contributed that technical informations has been correctly and rapidly searched. Designing of devices etc. and making of reports have become easy and work has been efficiently and rationally accomplished. (author)

Technical development for geological disposal of high-level radioactive wastes

International Nuclear Information System (INIS)

Asano, Hidekazu; Sugino, Hiroyuki; Kawakami, Susumu; Yamanaka, Yumiko

1997-01-01

Technical developments for geological disposal of high-level radioactive wastes materials research and design technique for engineered barriers (overpack and buffer material) were studied to evaluate more reliable disposal systems for high-level radioactive wastes. A lifetime prediction model for the maximum corrosion depth of carbon steel was developed. A preferable alloys evaluation method for crevice corrosion was established for titanium. Swelling pressure and water permeability of bentonite as a buffer material was measured, and coupled hydro-thermo-mechanical analysis code for bentonite was also studied. The CIP (cold isostatic pressing) method for monolithically formed buffer material was tested. A concept study on operation equipment for the disposal site was performed. Activities of microorganisms involved in underground performance were investigated. (author)

Status of Safeguards and Separations Model Development at Plant and Molecular Levels

Energy Technology Data Exchange (ETDEWEB)

de Almeida, Valmor F [ORNL; Hay, Benjamin [ORNL; DePaoli, David W [ORNL

2009-10-01

A primary goal of the Safeguards and Separations IPSC effort is the development of process modeling tools that allow dynamic simulations of separations plant operations under various configurations and conditions, and integration of relevant safeguards analyses. A requirement of the effort is to develop codes on modern, expandable architectures, with flexibility to explore and evaluate a wide range of process options. During FY09, efforts at ORNL have been focused on two priority tasks toward achieving the IPSC goal: (1) a top-down exploration of architecture - Subtask 1: Explore framework for code development and integration for plant-level simulation; and (2) a bottom-up fundamental modeling effort - Subtask 2: Development of molecular-level agent design code. Subtask 1 is important because definition and development of architecture is a key issue for the overall effort, as selection of an overall approach and code/data requirements is a necessary first step in the organization, design and development of separations and safeguards codes that will be incorporated. The agent design effort of Subtask 2 is a molecular-level modeling effort that has a direct impact on a near-term issue of the Separations and Waste Forms Campaign. A current focus of experimental efforts is the development of robust agents and processes for separation of Am/Cm. Development of enhanced agent-design codes will greatly accelerate discovery and experimental testing.

Status of Safeguards and Separations Model Development at Plant and Molecular Levels

International Nuclear Information System (INIS)

de Almeida, Valmor F.; Hay, Benjamin; DePaoli, David W.

2009-01-01

A primary goal of the Safeguards and Separations IPSC effort is the development of process modeling tools that allow dynamic simulations of separations plant operations under various configurations and conditions, and integration of relevant safeguards analyses. A requirement of the effort is to develop codes on modern, expandable architectures, with flexibility to explore and evaluate a wide range of process options. During FY09, efforts at ORNL have been focused on two priority tasks toward achieving the IPSC goal: (1) a top-down exploration of architecture - Subtask 1: Explore framework for code development and integration for plant-level simulation; and (2) a bottom-up fundamental modeling effort - Subtask 2: Development of molecular-level agent design code. Subtask 1 is important because definition and development of architecture is a key issue for the overall effort, as selection of an overall approach and code/data requirements is a necessary first step in the organization, design and development of separations and safeguards codes that will be incorporated. The agent design effort of Subtask 2 is a molecular-level modeling effort that has a direct impact on a near-term issue of the Separations and Waste Forms Campaign. A current focus of experimental efforts is the development of robust agents and processes for separation of Am/Cm. Development of enhanced agent-design codes will greatly accelerate discovery and experimental testing.

High-level enterprise and low-level radioactivity: two hazards in developing-country uranium concessions

International Nuclear Information System (INIS)

Erickson, D.M.; Gillis, M.

1980-01-01

Multinational uranium-mining activities in developing countries (LDCs) have posed new and important problems for LDCs because of the nature of the extractive enterprises and the nature of the mineral. If the LDCs are to realize their expected financial and growth objectives from uranium exploitation, they will need to exercise as much vigilance in negotiating and monitoring contracts with state-owned multinational enterprises as with privately-owned multinationals. In order for these objectives to be achieved without costly sacrifices in occupational health and the environment, LDC governments will need to develop concession agreements, mining codes, and public-health and labor standards that limit the scope of low-level radioactivity damage. 39 references

Development of a low-level waste risk methodology

International Nuclear Information System (INIS)

Fisher, J.E.; Falconer, K.L.

1984-01-01

A probabilistic risk assessment method is presented for performance evaluation of low-level waste disposal facilities. The associated program package calculates the risk associated with postulated radionuclide release and transport scenarios. Risk is computed as the mathematical product of two statistical variables: the dose consequence of a given release scenario, and its occurrence probability. A sample risk calculation is included which demonstrates the method. This PRA method will facilitate evaluation of facility performance, including identification of high risk scenarios and their mitigation via optimization of site parameters. The method is intended to be used in facility licensing as a demonstration of compliance with the performance objectives set forth in 10 CFR Part 61, or in corresponding state regulations. The Low-Level Waste Risk Methodology is being developed under sponsorship of the Nuclear Regulatory Commission

Corrective Action Investigation Plan for Corrective Action Unit 571: Area 9 Yucca Flat Plutonium Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Bailey, Bernadine; Matthews, Patrick

2013-07-01

CAU 571 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 571, which comprises the following corrective action sites (CASs): • 09-23-03, Atmospheric Test Site S-9F • 09-23-04, Atmospheric Test Site T9-C • 09-23-12, Atmospheric Test Site S-9E • 09-23-13, Atmospheric Test Site T-9D • 09-45-01, Windrows Crater These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report. The sites will be investigated based on the data quality objectives (DQOs) developed on March 6, 2013, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (now the Nevada Field Office). The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 571. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with CAU 571 CASs are from nuclear testing activities. The DQO process resulted in an assumption that total effective dose (TED) within a default contamination boundary exceeds the final action level (FAL) and requires corrective action. The presence and nature of contamination outside the default

Developing knowledge level scale of functional foods: Validity and ...

African Journals Online (AJOL)

The aim of the study was to develop a scale to determine the knowledge levels of University students on functional foods and to investigate the validity and reliability of the scale. The research was conducted on 417 (209 girls and 208 boys) undergraduate students in Selcuk University regarding functional foods.

ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19

Science.gov (United States)

Takahashi, Yuji; Fukuda, Yoko; Yoshimura, Jun; Toyoda, Atsushi; Kurppa, Kari; Moritoyo, Hiroyoko; Belzil, Veronique V.; Dion, Patrick A.; Higasa, Koichiro; Doi, Koichiro; Ishiura, Hiroyuki; Mitsui, Jun; Date, Hidetoshi; Ahsan, Budrul; Matsukawa, Takashi; Ichikawa, Yaeko; Moritoyo, Takashi; Ikoma, Mayumi; Hashimoto, Tsukasa; Kimura, Fumiharu; Murayama, Shigeo; Onodera, Osamu; Nishizawa, Masatoyo; Yoshida, Mari; Atsuta, Naoki; Sobue, Gen; Fifita, Jennifer A.; Williams, Kelly L.; Blair, Ian P.; Nicholson, Garth A.; Gonzalez-Perez, Paloma; Brown, Robert H.; Nomoto, Masahiro; Elenius, Klaus; Rouleau, Guy A.; Fujiyama, Asao; Morishita, Shinichi; Goto, Jun; Tsuji, Shoji

2013-01-01

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by the degeneration of motor neurons and typically results in death within 3–5 years from onset. Familial ALS (FALS) comprises 5%–10% of ALS cases, and the identification of genes associated with FALS is indispensable to elucidating the molecular pathogenesis. We identified a Japanese family affected by late-onset, autosomal-dominant ALS in which mutations in genes known to be associated with FALS were excluded. A whole- genome sequencing and parametric linkage analysis under the assumption of an autosomal-dominant mode of inheritance with incomplete penetrance revealed the mutation c.2780G>A (p. Arg927Gln) in ERBB4. An extensive mutational analysis revealed the same mutation in a Canadian individual with familial ALS and a de novo mutation, c.3823C>T (p. Arg1275Trp), in a Japanese simplex case. These amino acid substitutions involve amino acids highly conserved among species, are predicted as probably damaging, and are located within a tyrosine kinase domain (p. Arg927Gln) or a C-terminal domain (p. Arg1275Trp), both of which mediate essential functions of ErbB4 as a receptor tyrosine kinase. Functional analysis revealed that these mutations led to a reduced autophosphorylation of ErbB4 upon neuregulin-1 (NRG-1) stimulation. Clinical presentations of the individuals with mutations were characterized by the involvement of both upper and lower motor neurons, a lack of obvious cognitive dysfunction, and relatively slow progression. This study indicates that disruption of the neuregulin-ErbB4 pathway is involved in the pathogenesis of ALS and potentially paves the way for the development of innovative therapeutic strategies such using NRGs or their agonists to upregulate ErbB4 functions. PMID:24119685

Percepção dos perigos ambientais urbanos e os efeitos de lugar na relação população-ambiente

OpenAIRE

Marandola Jr., Eduardo; Modesto, Francine

2012-01-01

Os estudos ambientais enfrentam, desde seu advento, o fantasma da falácia ecológica. Especialmente no âmbito das ciências humanas, sempre houve uma atenção redobrada em relação a qualquer forma de determinismo geográfico ou interpretação que submetesse a compreensão da sociedade à lógica da natureza. Nos estudos de População e Ambiente (P-A), esta preocupação esteve sempre presente, não sendo raro o debate sobre a falácia ecológica, seus riscos e a busca por formas de eliminá-la do escopo das...

Perception Of Urban Environmental Threats And Place Effects On The Population-environment Relationship [percepção Dos Perigos Ambientais Urbanos E Os Efeitos De Lugar Na Relação População-ambiente

OpenAIRE

Marandola Jr. E.; Modesto F.

2012-01-01

Os estudos ambientais enfrentam, desde seu advento, o fantasma da falácia ecológica. Especialmente no âmbito das ciências humanas, sempre houve uma atenção redobrada em relação a qualquer forma de determinismo geográfico ou interpretação que submetesse a compreensão da sociedade à lógica da natureza. Nos estudos de População e Ambiente (P-A), esta preocupação esteve sempre presente, não sendo raro o debate sobre a falácia ecológica, seus riscos e a busca por formas de eliminá-la do escopo das...

The Impact of Sea Level Rise on Developing Countries: A Comparative Analysis

Energy Technology Data Exchange (ETDEWEB)

Dasgupta, S. [World Bank, Washington, DC (United States)

2008-07-01

Sea-level rise (SLR) due to climate change is a serious global threat: The scientific evidence is now overwhelming. In this paper, Geographic Information System software has been used to overlay the best available, spatially-disaggregated global data on land, population, agriculture, urban extent, wetlands, and GDP, to assess the consequences of continued SLR for 84 coastal developing countries. Estimates suggest that even a one-meter rise in sea level in coastal countries of the developing world would submerge 194,000 square kilometers of land area, and turn at least 56 million people into environmental refugees. At the country level results are extremely skewed.

The Impact of Sea Level Rise on Developing Countries: A Comparative Analysis

Energy Technology Data Exchange (ETDEWEB)

Dasgupta, Susmita (World Bank, Washington, DC (United States))

2008-07-01

Sea-level rise (SLR) due to climate change is a serious global threat: The scientific evidence is now overwhelming. In this paper, Geographic Information System software has been used to overlay the best available, spatially-disaggregated global data on land, population, agriculture, urban extent, wetlands, and GDP, to assess the consequences of continued SLR for 84 coastal developing countries. Estimates suggest that even a one-meter rise in sea level in coastal countries of the developing world would submerge 194,000 square kilometers of land area, and turn at least 56 million people into environmental refugees. At the country level results are extremely skewed

Leader Development Process in Pakistan Army at the Tactical Level

National Research Council Canada - National Science Library

Nawaz, Amer

2004-01-01

.... up to a maximum of seven years of service. It analyzes the present leader development process of Pakistan Army to see its effectiveness to train leaders at the tactical level to perform effectively in future...

Developing a network-level structural capacity index for structural evaluation of pavements.

Science.gov (United States)

2013-03-01

The objective of this project was to develop a structural index for use in network-level pavement evaluation to facilitate : the inclusion of the pavements structural condition in pavement management applications. The primary goal of network-level...

Features communikations media products and value system of teens

OpenAIRE

Гречаник, М. І.

2014-01-01

We investigate the genesis of the features of the relationship of media products and values as a teenager in the light of current trends in contemporary global information society, found that media products can influence the formation and development of personal values yk adolescence, due to physiological characteristics age. Media products meets the needs of adolescents and penetrates the subconscious, thus affecting the value system, which can lead to deformation of values as a teenager fal...

THE IMPACT OF THE ORADEA CITY ACADEMIC INSTITUTIONS ON THE ROMANIAN WEST (1780 - 2015)

OpenAIRE

Mihai D. DRECIN

2016-01-01

Even since the Greek-Roman antiquity, and then in the Middle Ages into the modern era and up until today, the “academies” and “universities” had an important role in the affirmation of the social-economic and cultural of the human environment where have emerged and developed. In the Europe of the Millennium II AD, these cultural and scientif ic institutions have emerged and they beamed from the West towards the Central and Eastern Europe. In the fal...

Development of the Level 1 PSA Model for PGSFR Regulatory

International Nuclear Information System (INIS)

Na, Hyun Ju; Lee, Yong Suk; Shin, Andong; Suh, Nam Duk

2014-01-01

SFR (sodium-cooled fast reactor) is Gen-IV nuclear energy system, which is designed for stability, sustainability and proliferation resistance. KALIMER-600 and PGSFR (Prototype Gen-IV SFR) are under development in Korea with enhanced passive safety concepts, e.g. passive reactor shutdown, passive residual heat removal, and etc. Risk analysis from a regulatory perspective is necessary for regulatory body to support the safety and licensing review of SFR. Safety issues should be identified in the early design phase in order to prevent the unexpected cost increase and the delay of PGSFR licensing schedule. In this respect, the preliminary PSA Model of KALIMER-600 had been developed for regulatory. In this study, the development of PSA Level 1 Model is presented. The important impact factors in the risk analysis for the PGSFR, such as Core Damage Frequency (CDF), have been identified and the related safety insights have been derived. The PSA level 1 model for PGSFR regulatory is developed and the risk analysis is conducted. Regarding CDF, LOISF frequency, uncertainty parameter for passive system CCF, loss of 125V DC control center bus and damper CCF are identified as the important factors. Sensitivity analyses show that the CDF would be differentiated (lowered) according to their values

Development and evaluation of candidate high-level waste forms

International Nuclear Information System (INIS)

Bernadzikowski, T.A.

1981-01-01

Some seventeen candidate waste forms have been investigated under US Department of Energy programs as potential media for the immobilization and geologic disposal of the high-level radioactive wastes (HLW) resulting from chemical processing of nuclear reactor fuels and targets. Two of these HLW forms were selected at the end of fiscal year (FY) 1981 for intensive development if FY 1982 to 1983. Borosilicate glass was continued as the reference form. A crystalline ceramic waste form, SYNROC, was selected for further product formulation and process development as the alternative to borosilicate glass. This paper describes the bases on which this decision was made

Development of high-level waste solidification technology 1

Energy Technology Data Exchange (ETDEWEB)

Kim, Joon Hyung; Kim, Hwan Young; Kim, In Tae [and others

1999-02-01

Spent nuclear fuel contains useful nuclides as valuable resource materials for energy, heat and catalyst. High-level wastes (HLW) are expected to be generated from the R and D activities and reuse processes. It is necessary to develop vitrification or advanced solidification technologies for the safe long-term management of high level wastes. As a first step to establish HLW vitrification technology, characterization of HLWs that would arise at KAERI site, glass melting experiments with a lab-scale high frequency induction melter, and fabrication and property evaluation of base-glass made of used HEPA filter media and additives were performed. Basic study on the fabrication and characterization of candidate ceramic waste form (Synroc) was also carried out. These HLW solidification technologies would be directly useful for carrying out the R and Ds on the nuclear fuel cycle and waste management. (author). 70 refs., 29 tabs., 35 figs.

Bioenergetic Defects and Oxidative Damage in Transgenic Mouse Models of Neurodegenerative Disorders

National Research Council Canada - National Science Library

Brown, Susan

1999-01-01

... (HE) and familial amyotrophic lateral sclerosis (FALS), using transgenic mouse models. Studies in this first year employed C-14-2-deoxyglucose in vivo autoradiography and spectrophotometric metabolic enzyme assays...

Managing Risk Areas in Software Development Offshoring: A CMMI Level 5 Case

DEFF Research Database (Denmark)

Persson, John Stouby; Schlichter, Bjarne Rerup

2015-01-01

Software companies are increasingly offshoring development to countries with high expertise at lower cost. Offshoring involves particular risk areas that if ignored increase the likelihood of failure. However, the offshoring client’s maturity level may influence the management of these risk areas....... Against this backdrop, we present an interpretive case study of how managers perceive and mitigate the risk areas in software development offshoring with a mature CMMI level 5 (Capability Maturity Model, Integrated) software company as the client. We find that managers perceive and mitigate most...

Relationships among Physical Activity Levels, Psychomotor, Psychosocial, and Cognitive Development of Primary Education Students.

Science.gov (United States)

Isler, Ayse Kin; Asci, F. Hulya; Kosar, S. Nazan

2002-01-01

Investigated the relationships of physical activity levels and psychomotor, psychosocial, and cognitive development among Turkish elementary school students. Student evaluations indicated that physical activity level was an important factor in determining student psychomotor development, but it was not important in determining psychosocial and…

Classification of EU Countries in Terms of the Level of Sustainable Development

Directory of Open Access Journals (Sweden)

Stec Małgorzata

2017-01-01

Full Text Available This article has classified the EU countries in terms of the level of sustainable development. The study was based on main sustainability indicators developed by Eurostat. In empirical research, one of the methods used was Cluster Analysis - Ward's method. Grouping methods make it possible to distinguish countries with a similar level of sustainability which is particularly useful for monitoring the progress of individual EU countries in implementation of the Sustainable Development Strategy. For specific groups of countries, appropriate control instruments and strategies can be proposed. The research period is 2016. As a result of the research, 6 clusters of countries were obtained. For specific groups of countries, their characteristics were defined.

Developing a Geoscience Literacy Exam: Pushing Geoscience Literacy Assessment to New Levels

Science.gov (United States)

Iverson, E. A.; Steer, D. N.; Manduca, C. A.

2012-12-01

InTeGrate is a community effort aimed at improving geoscience literacy and building a workforce that can use geoscience to solve societal issues. As part of this work we have developed a geoscience literacy assessment instrument to measure students' higher order thinking. This assessment is an important part of the development of curricula designed to increase geoscience literacy for all undergraduate students. To this end, we developed the Geoscience Literacy Exam (GLE) as one of the tools to quantify the effectiveness of these materials on students' understandings of geoscience literacy. The InTeGrate project is a 5-year, NSF-funded STEP Center grant in its first year of funding. Details concerning the project are found at http://serc.carleton.edu/integrate/index.html. The GLE instrument addresses content and concepts in the Earth, Climate, and Ocean Science literacy documents. The testing schema is organized into three levels of increasing complexity. Level 1 questions are single answer, understanding- or application-level multiple choice questions. For example, selecting which type of energy transfer is most responsible for the movement of tectonic plates. They are designed such that most introductory level students should be able to correctly answer after taking an introductory geoscience course. Level 2 questions are more advanced multiple answer/matching questions, at the understanding- through analysis-level. Students might be asked to determine the types of earth-atmosphere interactions that could result in changes to global temperatures in the event of a major volcanic eruption. Because the answers are more complicated, some introductory students and most advanced students should be able to respond correctly. Level 3 questions are analyzing- to evaluating-level short essays, such as describe the ways in which the atmosphere sustains life on Earth. These questions are designed such that introductory students could probably formulate a rudimentary response

Development and applications of new type isotope level-meters for cement factories

International Nuclear Information System (INIS)

Yang Shiqing; Min Hainian; Zhang Zhaoqing; Fu Heping; Dang Congjun; Wang Jingmin; Xia Junming

1998-01-01

According to the situation of current domestic switch isotope level-meters used for the level measurement and control in cement factories, a new type isotope level-meter is developed. The level-meter includes digit display circuit, count detection and control circuit and two ways control export, its response time is less than 1 second. The quenching circuit in the detector lengthens the using lifespan of G-M counter. The application in the factories indicates that the level-meter has the advantages of sensitive, strong anti-disturbance, reliable and adjustment simplicity. The use of the level-meter can make the better economy benefit and society benefit

Development and application of the variable focus laser leveling gage

International Nuclear Information System (INIS)

Gong Kun; Ma Jinglong

2005-01-01

The variable focus laser leveling gage was developed. The performance and structure were introduced. The several alignments and tests in KrF laser angle multi-path optical system were accomplished with them. Its application in other optical equipment was discussed too. (author)

Operationalising Ecologically Sustainable Development at the Micro Level Pareto Optimality and the Preservation of Biologically Crucial Levels.

NARCIS (Netherlands)

Bithas, K.; Nijkamp, P.

2006-01-01

The concept of Ecologically Sustainable Economic Development (ESED) has led to relentlessly heated debate. Yet, it still remains without a clear operational framework. At the micro level where a multitude of projects and programmes are designed, the absence of operational principles has serious

Developing Multi-Level Institutions from Top-Down Ancestors

Directory of Open Access Journals (Sweden)

Martha Dowsley

2007-11-01

Full Text Available The academic literature contains numerous examples of the failures of both top-down and bottom-up common pool resource management frameworks. Many authors agree that management regimes instead need to utilize a multi-level governance approach to meet diverse objectives in management. However, many currently operating systems do not have that history. This paper explores the conversion of ancestral top-down regimes to complex systems involving multiple scales, levels and objectives through the management of the polar bear (Ursus maritimus in its five range countries. The less successful polar bear management systems continue to struggle with the challenges of developing institutions with the capacity to learn and change, addressing multiple objectives while recognizing the conservation backbone to management, and matching the institutional scale with biophysical, economic and social scales. The comparatively successful institutions incorporate these features, but reveal on-going problems with vertical links that are partially dealt with through the creation of links to other groups.

Negotiating rural tourism development at the local level : a case study in Pisece, Slovenia

NARCIS (Netherlands)

Verbole, A.

1999-01-01

This study examines the policy and politics of the development of rural tourism at the local level in Slovenia. Its purpose was to increase our understanding of the socio-political dimensions of the rural tourism development process at the local community level by contributing to the

DEVELOPMENT OF THE LEVEL INDICES SYSTEM OF UNIVERSITY INTERNATIONALIZATION

Directory of Open Access Journals (Sweden)

Artem R. Denisov

2015-01-01

Full Text Available The aim of the investigation is to show possible variants of audit in the higher educational institution while processes of internationalisation (procedures of definition of its level; to find out an estimation method of the received results in the given sphere.Methods. The methods involve comparative analysis, synthesis, range and systematization of information concerning the discussed problem.Results and scientific novelty. The necessity of universities participating in internationalization processes is proved. Existing approaches to internationalization evaluation levels are reviewed, as well as best practices for each criterion. Level indicators of considered process are proposed due to summarising the results of the given review, and also as a result of the coordination of criteria NAFSA and authors’ system of indicators: international programs supporting by a university administration, curricular changes, faculty involving into international research, faculty involving into teaching process, students participation, abroad study support, international students and teachers support. The research demonstrates that to improve the adequacy the system of indicators has to be supplemented with some indicators to evaluate the conformity of a university’s internationalization to its mission; the conformity of a university’s internationalization to the government geopolitics; extracurricular activities of students; cultural aspects of internationalization including communication with local ethnical groups; attractiongetting mechanisms for international students.Practical significance. The proposed system of indicators can be used for an estimation of high school development in internationalisation sphere, and under certain correction and improvement for efficiency definition of development of its academic divisions in the given field.

Macro-level integrated renewable energy production schemes for sustainable development

International Nuclear Information System (INIS)

Subhadra, Bobban G.

2011-01-01

The production of renewable clean energy is a prime necessity for the sustainable future existence of our planet. However, because of the resource-intensive nature, and other challenges associated with these new generation renewable energy sources, novel industrial frameworks need to be co-developed. Integrated renewable energy production schemes with foundations on resource sharing, carbon neutrality, energy-efficient design, source reduction, green processing plan, anthropogenic use of waste resources for the production green energy along with the production of raw material for allied food and chemical industries is imperative for the sustainable development of this sector especially in an emission-constrained future industrial scenario. To attain these objectives, the scope of hybrid renewable production systems and integrated renewable energy industrial ecology is briefly described. Further, the principles of Integrated Renewable Energy Park (IREP) approach, an example for macro-level energy production, and its benefits and global applications are also explored. - Research highlights: → Discusses the need for macro-level renewable energy production schemes. → Scope of hybrid and integrated industrial ecology for renewable energy production. → Integrated Renewable Energy Parks (IREPs): A macro-level energy production scheme. → Discusses the principle foundations and global applications of IREPs. → Describes the significance of IREPs in the carbon-neutral future business arena.

Early postnatal docosahexaenoic acid levels and improved preterm brain development

OpenAIRE

Tam, Emily W.Y.; Chau, Vann; Barkovich, A. James; Ferriero, Donna M.; Miller, Steven P.; Rogers, Elizabeth E.; Grunau, Ruth E.; Synnes, Anne R.; Xu, Duan; Foong, Justin; Brant, Rollin; Innis, Sheila M.

2016-01-01

Background Preterm birth has a dramatic impact on polyunsaturated fatty acid exposures for the developing brain. This study examined the association between postnatal fatty acid levels and measures of brain injury and development, as well as outcomes. Methods A cohort of 60 preterm newborns (24?32 weeks GA) was assessed using early and near-term MRI studies. Red blood cell fatty acid composition was analyzed coordinated with each scan. Outcome at a mean of 33 months corrected age was assessed...

Individual-level outcomes from a national clinical leadership development programme.

Science.gov (United States)

Patton, Declan; Fealy, Gerard; McNamara, Martin; Casey, Mary; Connor, Tom O; Doyle, Louise; Quinlan, Christina

2013-08-01

A national clinical leadership development programme was instituted for Irish nurses and midwives in 2010. Incorporating a development framework and leadership pathway and a range of bespoke interventions for leadership development, including workshops, action-learning sets, mentoring and coaching, the programme was introduced at seven pilot sites in the second half of 2011. The programme pilot was evaluated with reference to structure, process and outcomes elements, including individual-level programme outcomes. Evaluation data were generated through focus groups and group interviews, individual interviews and written submissions. The data provided evidence of nurses' and midwives' clinical leadership development through self and observer-reported behaviours and dispositions including accounts of how the programme participants developed and displayed particular clinical leadership competencies. A key strength of the new programme was that it involved interventions that focussed on specific leadership competencies to be developed within the practice context.

An interview study of how clinical teachers develop skills to attend to different level learners.

Science.gov (United States)

Chen, H Carrie; Fogh, Shannon; Kobashi, Brent; Teherani, Arianne; Ten Cate, Olle; O'Sullivan, Patricia

2016-06-01

One clinical teaching challenge is the engagement of learners at different levels. Faculty development offerings mostly address general strategies applicable to all learners. This study examined how clinical faculty members develop the skills to work with different level learners. We conducted semi-structured interviews with medical school faculty members identified as excellent clinical teachers teaching multiple levels of learners. They discussed how they developed their approach to teaching different level learners and how their teaching evolved over time. We performed thematic analysis of the interview transcripts using open and axial coding. We interviewed 19 faculty members and identified three themes related to development of teaching practices: teacher agency and work-based learning of teaching strategies, developmental trajectory of clinical teachers, and interplay between clinical confidence and teaching skills. Faculty members were proactive in using on-the-job experiences to develop their teaching practices. Their teaching practices followed a developmental trajectory towards learner centeredness, and this evolution was associated with the development of clinical skills and confidence. Learning skills to teach multi-level learners requires workplace learning. Faculty development should include workplace learning opportunities and use a developmental approach that accounts for the trajectory of teaching as well as clinical skills attainment.

The Development of a Tactical-Level Full Range Leadership Measurement Instrument

Science.gov (United States)

2010-03-01

full range leadership theory has become established as the predominant and most widely researched theory on leadership . The most commonly used survey...instrument to assess full range leadership theory is the Multifactor Leadership Questionnaire, originally developed by Bass in 1985. Although much...existing literature to develop a new full range leadership theory measurement instrument that effectively targets low- to mid-level supervisors, or

Projets de developpement de curriculum niveau secondaire (Secondary Level Curriculum Development Projects).

Science.gov (United States)

Martin, Anne L.

Two Australian language curriculum development projects are discussed: the Australian Language Levels (ALL) Project and the National Assessment Framework for Languages at Senior Secondary Level (NAFLSSL). While distinct, both projects are closely linked. Each project was launched in 1985 in a favorable climate and in response to cost, enrollment,…

Analysis of the Level of Development of the Socio-labour Sphere of Ukrainian Regions

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Bibikova Viktoriia V.

2013-12-01

Full Text Available The goal of the article is the study of the level of development of the socio-labour sphere of Ukrainian regions. In order to achieve the goal, the article develops a complex scorecard, which takes into account all elements of the socio-labour sphere (socio-labour relations, labour market system of labour reimbursement, social accompaniment of labour activity, professional development of economically active population, level and quality of labour life, safety and security of labour. On the basis of the use of the developed scorecard, the article conducts an integral assessment of the level of development of the socio-labour sphere of regions. In order to get more objective information about the state of the labour sphere of Ukraine, the article uses its subjective assessments by population. In the result of the analysis, it reveals a lack of progressive changes of the socio-labour sphere in majority (60% of Ukrainian regions, availability of significant differentiation of regions by the level of its development and the irregular character of changes of separate elements of the labour sphere both within one administrative and territorial unit and among different regions of Ukraine. The article justifies a necessity of conduct of regular diagnostics of the state of the socio-labour sphere of Ukrainian regions with the use of a developed scorecard.

Maternal Serum and Amniotic Fluid Inhibin A Levels in Women who Subsequently Develop Severe Preeclampsia

Science.gov (United States)

Kim, Shin-Young; Yang, Jae-Hyug; Kim, Moon-Young; Ahn, Hyun-Kyong; Shin, Joong-Sik; Choi, Jun-Seek; Park, So-Yeon; Kim, Jin-Mi; Lee, Bom-Yi; Kim, Do-Jin

2006-01-01

The purpose of this study was to evaluate whether maternal serum (MS) and amniotic fluid (AF) inhibin A levels are elevated in patients who subsequently develop severe preecalmpsia, and to investigate the correlation between MS and AF inhibin A levels in the second trimester. The study included 40 patients who subsequently developed severe preecalmpsia and 80 normal pregnant women. Inhibin A levels in MS and AF were measured with enzyme-linked immunosorbent assay (ELISA). The MS and AF inhibin A levels in patients who developed severe preeclampsia were significantly higher than those in the control group (both for p<0.001). There was a positive correlation between MS and AF inhibin A levels in patients who developed severe preeclampsia (r=0.397, p=0.011), but not in the control group (r=0.185, p=0.126). The best cutoff values of MS and AF inhibin A levels for the prediction of severe preeclampsia were 427 pg/mL and 599 pg/mL, respectively; the estimated ORs that were associated with these cut-off values were 9.95 (95% CI 3.8-25.9, p<0.001) and 6.0 (95% CI 2.3-15.8, p<0.001). An elevated level of inhibin A in MS and AF at the time of second trimester amniocentesis may be a risk factor for the subsequent development of severe preeclampsia. PMID:16778388

The Effects of Promoting Educational Level on the Development of Reading Comprehension Levels in Hearing-Impaired Students

Directory of Open Access Journals (Sweden)

Mohammad Reza Sarmadi

2011-09-01

Full Text Available Background and Aim: Hearing-impaired students have some delays in learning language skills such as reading because of hearing loss. To study the effect of promoting educational level on the development of reading comprehension, the students of the 4th grade of elementary and last year guidance school were compared based on international test of reading literacy.Methods: The project was cross-sectional and the tool used was the international standard booklet of PIRLS 2001. Thirty-six students selected with moderately severe and severe hearing loss from the 4th grade of elementary and last year guidance school from Shahriar, Robatkarim, Karaj and Hashtgerd, Iran, exceptional schools. Comparative statistical analysis was performed using t-test.Results: The first level (focus on and retrieve explicity information showed a meaningful difference between the last year guidance school and the 4th grade of elementary students (p<0.05, but there were no significant differences in other levels, make straightforward information-interpret and integrate ideas-examine and evaluate content, (p> 0.05.Conclusion: Hearing-impaired students have difficulties in understanding in deep levels of reading despite promoting educational level. Thus, in making policies for special trainings, continuing the rehabilitation in guidance and high school levels to promote the complex levels of comprehension should be taken more into consideration.

Development of level 2 processor for the readout of TMC

International Nuclear Information System (INIS)

Arai, Y.; Ikeno, M.; Murata, T.; Sudo, F.; Emura, T.

1995-01-01

We have developed a prototype 8-bit processor for the level 2 data processing for the Time Memory Cell (TMC). The first prototype processor successfully runs with 18 MHz clock. The operation of same clock frequency as TMC (30 MHz) will be easily achieved with simple modifications. Although the processor is very primitive one but shows its powerful performance and flexibility. To realize the compact TMC/L2P (Level 2 Processor) system, it is better to include the microcode memory within the chip. Encoding logic of the microcode must be included to reduce the microcode memory in this case. (J.P.N.)

Classification of the European Union member states according to the relative level of sustainable development.

Science.gov (United States)

Anna, Bluszcz

Nowadays methods of measurement and assessment of the level of sustained development at the international, national and regional level are a current research problem, which requires multi-dimensional analysis. The relative assessment of the sustainability level of the European Union member states and the comparative analysis of the position of Poland relative to other countries was the aim of the conducted studies in the article. EU member states were treated as objects in the multi-dimensional space. Dimensions of space were specified by ten diagnostic variables describing the sustainability level of UE countries in three dimensions, i.e., social, economic and environmental. Because the compiled statistical data were expressed in different units of measure, taxonomic methods were used for building an aggregated measure to assess the level of sustainable development of EU member states, which through normalisation of variables enabled the comparative analysis between countries. Methodology of studies consisted of eight stages, which included, among others: defining data matrices, calculating the variability coefficient for all variables, which variability coefficient was under 10 %, division of variables into stimulants and destimulants, selection of the method of variable normalisation, developing matrices of normalised data, selection of the formula and calculating the aggregated indicator of the relative level of sustainable development of the EU countries, calculating partial development indicators for three studies dimensions: social, economic and environmental and the classification of the EU countries according to the relative level of sustainable development. Statistical date were collected based on the Polish Central Statistical Office publication.

ENDOGENOUS OR EXOGENOUS INNOVATION DEVELOPMENT IN INDUSTRY ON REGIONAL LEVEL?

Directory of Open Access Journals (Sweden)

Arkadiusz Świadek

2014-04-01

Full Text Available At the moment endogenous growth theory has become increasingly popular in the world of science, particularly in developed countries. This article aims to show, for two regions case, the needs and sense of applying this theory in the polish regions. Due to the low level of economic development of many Polish regions, they are unable to growth in a comparable rate as regions in developed countries. This explains the economic divergence between polish regions and the highly developed regions of Europe and the World. Stimulating economic growth is insufficient in such cases, because of the weakness of its internal factors. Therefore it is important to strengthen an external impact to keep internal development. It means that the endogenous growth theory is no reason to exist, in conditions of poor polish regions. Without external inputs there can’t be convergences processes. Therefore, the economic development of the Polish regions should be based on the exogenous growth theory.

Development of a geoscience database for preselecting China's high level radioactive waste disposal sites

International Nuclear Information System (INIS)

Li Jun; Fan Ai; Huang Shutao; Wang Ju

1998-01-01

Taking the development of a geoscience database for China's high level waste disposal sites: Yumen Town, Gansu Province, northwest of China, as an example, the author introduces in detail the application of Geographical Information System (GIS) to high level waste disposal and analyses its application prospect in other fields. The development of GIS provides brand-new thinking for administrators and technicians at all levels. At the same time, the author also introduces the administration of maps and materials by using Geographical Information System

Development of the Nursing Outcome (NOC) label: hyperactivity level.

Science.gov (United States)

Caldwell, Carol L; Wasson, Dianne; Anderson, Mary Ann; Brighton, Veronica; Dixon, Lois

2005-01-01

Hyperactivity, a persistent, severe pattern of inattention or impulsivity, places children at risk for impaired functioning in many developmental areas. This behavior is characterized by short attention span, low frustration tolerance, impulsivity, distractibility, and increased physical activity. Responses from multiple sources in the child's environment must be monitored to manage childhood hyperactivity. Success at school, in peer relationships, and parent-child interactions is frequently affected by hyperactivity. Using a focus group approach, a Nursing Outcomes Classification (NOC) label, definition, and indicators were developed for Hyperactivity Level. Review of the literature allowed for a content analysis approach and conceptualization of hyperactivity at several levels. Twenty three (23) measurable indicators were formulated and refined into conceptually and clinically coherent outcomes. Clinical relevance and utility were presented through a case study approach.

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.

Directory of Open Access Journals (Sweden)

Edward Pokrishevsky

Full Text Available Mutant Cu/Zn superoxide dismutase (SOD1 can confer its misfolding on wild-type SOD1 in living cells; the propagation of misfolding can also be transmitted between cells in vitro. Recent studies identified fluorescently-tagged SOD1G85R as a promiscuous substrate that is highly prone to aggregate by a variety of templates, in vitro and in vivo. Here, we utilized several SOD1-GFP reporter proteins with G37R, G85R, or G93A mutations in SOD1. We observed that human spinal cord homogenates prepared from SOD1 familial ALS (FALS can induce significantly more intracellular reporter protein aggregation than spinal cord homogenates from sporadic ALS, Alzheimer's disease, multiple system atrophy or healthy control individuals. We also determined that the induction of reporter protein aggregation by SOD1-FALS tissue homogenates can be attenuated by incubating the cells with the SOD1 misfolding-specific antibody 3H1, or the small molecule 5-fluorouridine. Our study further implicates SOD1 as the seeding particle responsible for the spread of SOD1-FALS neurodegeneration from its initial onset site(s, and demonstrates two potential therapeutic strategies for SOD1-mediated disease. This work also comprises a medium-throughput cell-based platform of screening potential therapeutics to attenuate propagated aggregation of SOD1.

MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis

Directory of Open Access Journals (Sweden)

Joshua L. Heuslein

2018-01-01

Full Text Available The growth of endogenous collateral arteries that bypass arterial occlusion(s, or arteriogenesis, is a fundamental shear stress-induced adaptation with implications for treating peripheral arterial disease. MicroRNAs (miRs are key regulators of gene expression in response to injury and have strong therapeutic potential. In a previous study, we identified miR-146a as a candidate regulator of vascular remodeling. Here, we tested whether miR-146a regulates in vitro angiogenic endothelial cell (EC behaviors, as well as perfusion recovery, arteriogenesis, and angiogenesis in response to femoral arterial ligation (FAL in vivo. We found miR-146a inhibition impaired EC tube formation and migration in vitro. Following FAL, Balb/c mice were treated with a single, intramuscular injection of anti-miR-146a or scramble locked nucleic acid (LNA oligonucleotides directly into the non-ischemic gracilis muscles. Serial laser Doppler imaging demonstrated that anti-miR-146a treated mice exhibited significantly greater perfusion recovery (a 16% increase compared mice treated with scramble LNA. Moreover, anti-miR-146a treated mice exhibited a 22% increase in collateral artery diameter compared to controls, while there was no significant effect on in vivo angiogenesis or muscle regeneration. Despite exerting no beneficial effects on angiogenesis, the inhibition of mechanosensitive miR-146a enhances perfusion recovery after FAL via enhanced arteriogenesis.

Development of a geoscience database for preselecting China's high level radioactive waste disposal sites

International Nuclear Information System (INIS)

Li Jun; Fan Ai; Huang Shutao; Wang Ju

2004-01-01

Taking the development of a geoscience database for China's high level waste disposal sites: Yumen Town, Guansu province, northwest of China, as an example, this paper introduces in detail the application of Geographical Information System (GIS) to high level waste disposal and analyses its application prospect in other fields. The development of GIS provides brand-new thinking for administrators and technicians at all levels. At the same time, this paper also introduces the administration of maps and materials by using Geographical Information System. (author)

75 FR 6027 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

Science.gov (United States)

2010-02-05

... Agrochemicals Ltd. requesting an experimental use permit (EUP) for the end-use product FAL 1800, containing the... Agrochemicals Ltd., (62097-EUP-R). Pesticide Chemical: Prohydrojasmon (PDJ). Summary of Request: Use as a plant...

Stakeholder co-development of farm level nutrient management software

Science.gov (United States)

Buckley, Cathal; Mechan, Sarah; Macken-Walsh, Aine; Heanue, Kevin

2013-04-01

Over the last number of decades intensification in the use nitrogen (N) and phosphorus (P) in agricultural production has lead to excessive accumulations of these nutrients in soils, groundwaters and surface water bodies (Sutton et al., 2011). According to the European Environment Agency (2012) despite some progress diffuse pollution from agriculture is still significant in more than 40% of Europe's water bodies in rivers and coastal waters, and in one third of the water bodies in lakes and transitional waters. Recently it was estimated that approximately 29% of monitored river channel length is polluted to some degree across the Republic of Ireland. Agricultural sources were suspected in 47 per cent of cases (EPA, 2012). Farm level management practices to reduce nutrient transfers from agricultural land to watercourses can be divided into source reduction and source interception approaches (Ribaudo et al., 2001). Source interception approaches involve capturing nutrients post mobilisation through policy instruments such as riparian buffer zones or wetlands. Conversely, the source reduction approach is preventative in nature and promotes strict management of nutrient at farm and field level to reduce risk of mobilisation in the first instance. This has the potential to deliver a double dividend of reduced nutrient loss to the wider ecosystem while maximising economic return to agricultural production at the field and farm levels. Adoption and use of nutrient management plans among farmers is far from the norm. This research engages key farmer and extension stakeholders to explore how current nutrient management planning software and outputs should be developed to make it more user friendly and usable in a practical way. An open innovation technology co-development approach was adopted to investigate what is demanded by the end users - farm advisors and farmers. Open innovation is a knowledge management strategy that uses the input of stakeholders to improve

High-level Waste Long-term management technology development

International Nuclear Information System (INIS)

Choi, Jong Won; Kang, C. H.; Ko, Y. K.

2012-02-01

The purpose of this project is to develop a long-term management system(A-KRS) which deals with spent fuels from domestic nuclear power stations, HLW from advanced fuel cycle and other wastes that are not admitted to LILW disposal site. Also, this project demonstrate the feasibility and reliability of the key technologies applied in the A-KRS by evaluating them under in-situ condition such as underground research laboratory and provide important information to establish the safety assessment and long-term management plan. To develop the technologies for the high level radioactive wastes disposal, demonstrate their reliability under in-situ condition and establish safety assessment of disposal system, The major objects of this project are the following: Ο An advanced disposal system including waste containers for HLW from advanced fuel cycle and pyroprocess has been developed. Ο Quantitative assessment tools for long-term safety and performance assessment of a radwaste disposal system has been developed. Ο Hydrological and geochemical investigation and interpretation methods has been developed to evaluate deep geological environments. Ο The THMC characteristics of the engineered barrier system and near-field has been evaluated by in-situ experiments. Ο The migration and retardation of radionuclides and colloid materials in a deep geological environment has been investigated. The results from this project will provide important information to show HLW disposal plan safe and reliable. The knowledge from this project can also contribute to environmental conservation by applying them to the field of oil and gas industries to store their wastes safe

ASPECTS ON THE ACTUAL LEVEL OF EDUCATIONAL DEVELOPMENT AT THE SOUTH-WEST REGION OLTENIA

Directory of Open Access Journals (Sweden)

CHIRCULESCU MARIA FELICIA

2017-08-01

Full Text Available Due to the complexity of the educational sector, the work is topical, even though over time there have been many concerns regarding its education and development and the correlation between the level of educational development and the level of economic development. The aim of the paper is to analyze the educational development at the level of the South-West Oltenia region over the period 2010-2015, thus using the statistical series for the mentioned timeframe we analyzed the evolution of the number of educational units in the South-West Oltenia region And the evolution of the school population in the South-West Oltenia region. Thus, the objective of the paper is enshrined in the overall objective of Romania, namely to reduce the economic and social development disparities between Romania and other EU Member States. The results of the analysis carried out by the two indicators, the number of educational units in the South-West Oltenia region and the number of the school population at the level of the South-West Oltenia region indicate that the number of educational units in the period 2010-2015 decreased by 4.28% And the number of the school population by 14.67%.

A Importância do Planejamento Tributário nas Micro e Pequenas Empresas

Directory of Open Access Journals (Sweden)

Lucilaine Escobar Teixeira Sampaio

2015-06-01

Full Text Available O objetivo geral deste estudo é demonstrar a importância do planejamento tributário para as micro e pequenas empresas (MPE no Brasil. Já os alvos específicos são: identificar as formas de tributação existentes que podem ser utilizadas pelas MPE e verificar qual é a mais viável. Para atingir os objetivos deste estudo, foi realizada pesquisa bibliográfica a partir de artigos e livros do acervo da Faculdade Anhanguera, da Universidade Católica Dom Bosco (UCDB e de acervos pessoais, bem como de artigos de periódicos e legislação disponíveis na internet e manuais de pesquisa no site do Serviço Brasileiro de Apoio às Micro e Pequenas Empresas (Sebrae. Dos resultados encontrados, verificou-se que as MPE possuem papel relevante para a economia e, por esse motivo, o governo, nas últimas décadas, tem proporcionado vários incentivos visando estimular a abertura de mais empresas desse porte, bem como evitar que muitas entrem em falência, tendo em vista que pesquisas realizadas, principalmente pelo Sebrae, demonstram que é alto o índice de MPE que entram em falência todos os anos. Nas últimas décadas, após os incentivos adotados, entre eles a criação do Simples, nova forma de tributação especial para as MPE, verificou-se uma redução no fechamento de empresas desse porte, porém, o índice continua elevado. Várias são as causas para a falência das MPE, e dentre elas se destaca a alta carga tributária. Dessa forma, torna-se imprescindível que os empresários invistam na realização do planejamento tributário, a fim de escolher a melhor forma de tributação para evitar a falência.

Development of a Health-Protective Drinking Water Level for Perchlorate

Science.gov (United States)

Ting, David; Howd, Robert A.; Fan, Anna M.; Alexeeff, George V.

2006-01-01

We evaluated animal and human toxicity data for perchlorate and identified reduction of thyroidal iodide uptake as the critical end point in the development of a health-protective drinking water level [also known as the public health goal (PHG)] for the chemical. This work was performed under the drinking water program of the Office of Environmental Health Hazard Assessment of the California Environmental Protection Agency. For dose–response characterization, we applied benchmark-dose modeling to human data and determined a point of departure (the 95% lower confidence limit for 5% inhibition of iodide uptake) of 0.0037 mg/kg/day. A PHG of 6 ppb was calculated by using an uncertainty factor of 10, a relative source contribution of 60%, and exposure assumptions specific to pregnant women. The California Department of Health Services will use the PHG, together with other considerations such as economic impact and engineering feasibility, to develop a California maximum contaminant level for perchlorate. We consider the PHG to be adequately protective of sensitive subpopulations, including pregnant women, their fetuses, infants, and people with hypothyroidism. PMID:16759989

Addendum to the Closure Report for Corrective Action Unit 404: Roller Coaster Sewage Lagoons and North Disposal Trench, Tonopah Test Range, Nevada, Revision 1

Energy Technology Data Exchange (ETDEWEB)

Lynn Kidman

2009-02-01

This document constitutes an addendum to the September 1998, Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the modification of the UR for CAS TA-03-001-TARC Roller Coaster Lagoons. This UR was established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and was based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This reevaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to modify the UR for CAS TA-03

Development and methodology of level 1 probability safety assessment at PUSPATI TRIGA Reactor

International Nuclear Information System (INIS)

Maskin, Mazleha; Tom, Phongsakorn Prak; Lanyau, Tonny Anak; Saad, Mohamad Fauzi; Ismail, Ahmad Razali; Abu, Mohamad Puad Haji; Brayon, Fedrick Charlie Matthew; Mohamed, Faizal

2014-01-01

As a consequence of the accident at the Fukushima Dai-ichi Nuclear Power Plant in Japan, the safety aspects of the one and only research reactor (31 years old) in Malaysia need be reviewed. Based on this decision, Malaysian Nuclear Agency in collaboration with Atomic Energy Licensing Board and Universiti Kebangsaan Malaysia develop a Level-1 Probability Safety Assessment on this research reactor. This work is aimed to evaluate the potential risks of incidents in RTP and at the same time to identify internal and external hazard that may cause any extreme initiating events. This report documents the methodology in developing a Level 1 PSA performed for the RTP as a complementary approach to deterministic safety analysis both in neutronics and thermal hydraulics. This Level-1 PSA work has been performed according to the procedures suggested in relevant IAEA publications and at the same time numbers of procedures has been developed as part of an Integrated Management System programme implemented in Nuclear Malaysia

Development and methodology of level 1 probability safety assessment at PUSPATI TRIGA Reactor

International Nuclear Information System (INIS)

Mazleha Maskin; Phongsakorn, P.T.; Tonny, A.L.; Fedrick, C.M.B.; Faizal Mohamed; Mohamad Fauzi Saad; Ahmad Razali Ismail; Mohamad Puad Haji Abu

2013-01-01

Full-text: As a consequence of the accident at the Fukushima Dai-ichi Nuclear Power Plant in Japan, the safety aspects of the one and only research reactor (31 years old) in Malaysia need be reviewed. Based on this decision, Malaysian Nuclear Agency in collaboration with Atomic Energy Licensing Board and Universiti Kebangsaan Malaysia develop a Level-1 Probability Safety Assessment on this research reactor. This work is aimed to evaluate the potential risks of incidents in RTP and at the same time to identify internal and external hazard that may cause any extreme initiating events. This report documents the methodology in developing a Level 1 PSA performed for the RTP as a complementary approach to deterministic safety analysis both in neutronics and thermal hydraulics. This Level-1 PSA work has been performed according to the procedures suggested in relevant IAEA publications and at the same time numbers of procedures has been developed as part of an Integrated Management System programme implemented in Nuclear Malaysia. (author)

Kalanchoe crop development under different levels of irrigation

Directory of Open Access Journals (Sweden)

Fátima Cibele Soares

Full Text Available ABSTRACT Despite its importance in the floriculture sector, irrigation management of kalanchoe is characterized by empiricism, being necessary further studies on the use of water by this crop. Thus, the objective of this study is to analyze the several effects of irrigation levels on the growth of kalanchoe crop conducted in greenhouse in the municipality of Alegrete, state of Rio Grande do Sul. The experiment was conducted in a 7 x 15 m protected environment. The experimental design was completely randomized, with four treatments (irrigation levels corresponding to 40, 60, 80 and 100% of the pot water retention capacity - PC and four repetitions, totaling sixteen plots. The crop cycle was 224 days after transplanting and the applied average depths were: 451.82; 367.38; 282.94; 198.51 mm for treatments: 100; 80; 60 and 40% of PC, respectively. Canopy area and number of leaves per plant were evaluated over the crop cycle. In the end of the cycle, the canopy diameter, number of inflorescences per plant and the number of flowers per plant were evaluated. No significant differences were found only to the canopy area, by the F test. Irrigation water depths between 40 and 70% of the pot capacity were more appropriate for the crop growth in the study region. The cultivar presented the best development at irrigation levels below the maximum vessel water retention capacity, that is, it is resistant to drought.

Seasonal Mean SST images of Stellwagen Bank National Marine Sanctuary

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Average seasonal sea surface temperatures http://podaac.jpl.nasa.gov/ Naming Convention: XXXX_SSSYYYY_SST.tif XXXX=location (Stell) SSS=season (FAL=fall, SPR=spring,...

Development of Fe-based superconducting wires for liquid-hydrogen level sensors

Science.gov (United States)

Ishida, S.; Tsuchiya, Y.; Mawatari, Y.; Eisaki, H.; Nakano, A.; Yoshida, Y.

2017-07-01

We developed liquid-hydrogen (LH2) level sensors with Ba(Fe1-x Co x )2As2 superconducting wires (Co-Ba122 wires) as their detection elements. We fabricated Co-Ba122 wires with different Co concentrations x by using the powder-in-tube method. The superconducting transition temperatures of the wires were successfully controlled in the range of 20-25 K by changing x from 0.06 to 0.10. The resistance-temperature curves of the wires exhibited sharp superconducting transitions with widths of 0.5-1.0 K. In addition, we performed an operation test of the Co-Ba122 level sensors with LH2. Close correspondence between the output resistance and the actual LH2 level was observed for a sensor equipped with x = 0.09 wire, demonstrating that this sensor can accurately measure LH2 levels.

Development of Speaking Skills through Activity Based Learning at the Elementary Level

Science.gov (United States)

Ul-Haq, Zahoor; Khurram, Bushra Ahmed; Bangash, Arshad Khan

2017-01-01

Purpose: This paper discusses an effective instructional method called "activity based learning" that can be used to develop the speaking skills of students in the elementary school level. The present study was conducted to determine the effect of activity based learning on the development of the speaking skills of low and high achievers…

Risk newsboy: approach for addressing uncertainty in developing action levels and cleanup limits

International Nuclear Information System (INIS)

Cooke, Roger; MacDonell, Margaret

2007-01-01

Site cleanup decisions involve developing action levels and residual limits for key contaminants, to assure health protection during the cleanup period and into the long term. Uncertainty is inherent in the toxicity information used to define these levels, based on incomplete scientific knowledge regarding dose-response relationships across various hazards and exposures at environmentally relevant levels. This problem can be addressed by applying principles used to manage uncertainty in operations research, as illustrated by the newsboy dilemma. Each day a newsboy must balance the risk of buying more papers than he can sell against the risk of not buying enough. Setting action levels and cleanup limits involves a similar concept of balancing and distributing risks and benefits in the face of uncertainty. The newsboy approach can be applied to develop health-based target concentrations for both radiological and chemical contaminants, with stakeholder input being crucial to assessing 'regret' levels. Associated tools include structured expert judgment elicitation to quantify uncertainty in the dose-response relationship, and mathematical techniques such as probabilistic inversion and iterative proportional fitting. (authors)

A comprehensive review of amyotrophic lateral sclerosis

Science.gov (United States)

Zarei, Sara; Carr, Karen; Reiley, Luz; Diaz, Kelvin; Guerra, Orleiquis; Altamirano, Pablo Fernandez; Pagani, Wilfredo; Lodin, Daud; Orozco, Gloria; Chinea, Angel

2015-01-01

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5–10% of the cases are familial ALS. Both sporadic and familial ALS (FALS) are associated with degeneration of cortical and spinal motor neurons. The etiology of ALS remains unknown. However, mutations of superoxide dismutase 1 have been known as the most common cause of FALS. In this study, we provide a comprehensive review of ALS. We cover all aspects of the disease including epidemiology, comorbidities, environmental risk factor, molecular mechanism, genetic factors, symptoms, diagnostic, treatment, and even the available supplement and management of ALS. This will provide the reader with an advantage of receiving a broad range of information about the disease. PMID:26629397

Management of Sustainable Energy Efficient Development at the Local Level: Stakeholder-Oriented Approach

Directory of Open Access Journals (Sweden)

Horban Vasylyna B.

2016-11-01

Full Text Available There presented a theoretical rationale for the expediency of using the stakeholder-oriented approach to improve the process of management of sustainable energy efficient development at the local level. The evolution of theories by scientific schools that studied the concepts of «stakeholders» and «interested parties» is analyzed and generalized. A classification of types of stakeholders in the context of eighteen typological features is suggested, which allows to more effectively align their interests and contributes to establishing constructive forms of cooperation in order to achieve efficient final results. An algorithm of interaction with interested parties in achieving the goals of sustainable energy efficient development at the local level is elaborated. Typical motivational interests of stakeholders at the local level in the field of sustainable energy efficient development (on the example of Ukraine are identified. Instruments of prioritization of stakeholders depending on the life cycle stages of energy efficiency projects are proposed. The results obtained in the course of the research can be used to develop local energy efficient programs, business plans and feasibility studies for energy efficient projects.

Revascularization and Muscle Adaptation to Limb Demand Ischemia in Diet Induced Obese Mice

Science.gov (United States)

Albadawi, Hassan; Tzika, Aria; Rask-Madsen, Christian; Crowley, Lindsey M.; Koulopoulos, Michael W.; Yoo, Hyung-Jin; Watkins, Michael T.

2016-01-01

Background Obesity and type 2 diabetes are major risk factors for peripheral arterial disease (PAD) in humans which can result in lower limb demand ischemia and exercise intolerance. Exercise triggers skeletal muscle adaptation including increased vasculogenesis. The goal of this study was to determine whether demand ischemia modulates revascularization, fiber size, and signaling pathways in the ischemic hind limb muscles of mice with diet-induced obesity (DIO). Materials and Methods DIO mice (n=7) underwent unilateral femoral artery ligation (FAL) and recovered for 2-weeks followed by 4-weeks with daily treadmill exercise to induce demand ischemia. A parallel sedentary ischemia group (n=7) had FAL without exercise. The contralateral limb muscles of sedentary ischemia served as control. Muscles were examined for capillary density, myofiber cross-sectional area (CSA), cytokine levels, and phosphorylation of STAT3 and ERK1/2. Results Exercise significantly enhanced capillary density (pdemand ischemia compared to sedentary ischemia. These findings coincided with a significant increase in G-CSF (pDemand ischemia increased the PGC1α mRNA (pdemands ischemia in the setting of DIO causes myofiber atrophy despite an increase in muscle capillary density. The combination of persistent increase in TNFα, lower VEGF and failure to increase PGC1α protein may reflect a deficient adaption to demand ischemia in DIO. PMID:27620999

Ethical considerations in the management of amyotrophic lateral sclerosis.

Science.gov (United States)

Eisen, Andrew; Krieger, Charles

2013-11-01

This article examines some of the ethical concerns relevant for the management of amyotrophic lateral sclerosis (ALS). We emphasize the importance for providing a competent assessment of the clinical deficit to correctly identify the disease and to avoid incorrect diagnoses. Conveying the diagnosis to the patient and their family requires empathy and it is important to remain supportive and positive, even in the face of this incurable disease. The essence of care in ALS is to permit the patient to have optimal function for their level of ability. This may require the use of gastrostomy and non-invasive or permanent ventilation. Employment of a multi-disciplinary team will permit optimization of patient care to achieve a good quality of life for as long as possible. The patient should also be informed of the risks associated with unproven therapies and the risks and potential benefits of therapeutic trials. The wishes of patients in regard to gastrostomy, long-term ventilation and end-of life decisions must be considered in an unbiased fashion. Recent advances in the genetics of familial ALS (FALS) have demonstrated some overlap between FALS, sporadic ALS and fronto-temporal lobar dementia (FTLD). The interpretation and dissemination of the results of genetic testing although important can induce confusion, considerable anxiety and guilt in patients and their families and proper counseling is imperative. Copyright © 2013 Elsevier Ltd. All rights reserved.

Development of low level alpha particle counting system

International Nuclear Information System (INIS)

Minobe, Masao; Kondo, Hiraku; Chinuki, Takashi; Hirano, Hiromichi

1987-01-01

Much attention has been paid to the trace analysis of uranium and thorium contained in the base material of LSI or VLSI, since the so-called ''soft-error'' of the memory device was known to be due to alpha particles emitted from these radioactive elements. We have developed an apparatus to meet the needs of estimating such a very small quantity of U and Th of the level of ppb, by directly counting alpha particles using a gas-flow type proportional counter. This method requires no sophisticated analytical skill, and the accuracy of the result is satisfactory. The instrumentation and some application of this apparatus are described. (author)

Women's Education Levels and Its Impact on Their Attitudes towards Children's Health Development

Science.gov (United States)

Bjorgen, Kathrine

2011-01-01

Relations between socio-economic differences and health have previously been well documented, but women's education level and relative attitudes towards children's health development has been seldom found in studies. This paper examines the relation between women's education level and their attitudes in understanding kindergarten children's health…

Historical Review of Uncommanded Lateral-Directional Motions at Transonic Conditions

Science.gov (United States)

Chambers, Joseph R.; Hall, Robert M.

2003-01-01

This paper presents the results of a survey of past experiences with uncommanded lateral-directional motions at transonic speeds during specific military aircraft programs. The effort was undertaken to provide qualitative and quantitative information on past airplane programs that might be of use to the participants in the joint NASA/Navy/Air Force Abrupt Wing Stall (AWS) Program. The AWS Program was initiated because of the experiences of the F/A-l8E/F development program, during which unexpected, severe wing-drop motions were encountered by preproduction aircraft at transonic conditions. These motions were judged to be significantly degrading to the primary mission requirements of the aircraft. Although the problem was subsequently solved for the production version of the F/A-l8E/F, a high-level review panel emphasized the poor understanding of such phenomena and issued a strong recommendation to: "Initiate a national research effort to thoroughly and systematically study the wing drop phenomena." A comprehensive, cooperative NASA/Navy/Air Force AWS Program was designed to respond to provide the required technology requirements. As part of the AWS Program, a work element was directed at a historical review of wing-drop experiences in past aircraft development programs at high subsonic and transonic speeds. In particular, information was requested regarding: specific aircraft configurations that exhibited uncommanded motions and the nature of the motions; geometric characteristics of the air- planes; flight conditions involved in occurrences; relevant data, including wind-tunnel, computational, and flight sources; figures of merit used for analyses; and approaches used to alleviate the problem. An attempt was also made to summarize some of the more important lessons learned from past experiences, and to recommend specific research efforts. In addition to providing technical information to assist the AWS research objectives, the study produced fundamental

Attempted development and cross-validation of predictive models of individual-level and organizational-level turnover of nuclear power operators

International Nuclear Information System (INIS)

Vasa-Sideris, S.J.

1989-01-01

Nuclear power accounts for 209% of the electric power generated in the U.S. by 107 nuclear plants which employ over 8,700 operators. Operator turnover is significant to utilities from the economic point of view since it costs almost three hundred thousand dollars to train and qualify one operator, and because turnover affects plant operability and therefore plant safety. The study purpose was to develop and cross-validate individual-level and organizational-level models of turnover of nuclear power plant operators. Data were obtained by questionnaires and from published data for 1983 and 1984 on a number of individual, organizational, and environmental predictors. Plants had been in operation for two or more years. Questionnaires were returned by 29 out of 50 plants on over 1600 operators. The objectives were to examine the reliability of the turnover criterion, to determine the classification accuracy of the multivariate predictive models and of categories of predictors (individual, organizational, and environmental) and to determine if a homology existed between the individual-level and organizational-level models. The method was to examine the shrinkage that occurred between foldback design (in which the predictive models were reapplied to the data used to develop them) and cross-validation. Results did not support the hypothesis objectives. Turnover data were accurate but not stable between the two years. No significant differences were detected between the low and high turnover groups at the organization or individual level in cross-validation. Lack of stability in the criterion, restriction of range, and small sample size at the organizational level were serious limitations of this study. The results did support the methods. Considerable shrinkage occurred between foldback and cross-validation of the models

Using a High-Performance Planning Model to Increase Levels of Functional Effectiveness Within Professional Development.

Science.gov (United States)

Winter, Peggi

2016-01-01

Nursing professional practice models continue to shape how we practice nursing by putting families and members at the heart of everything we do. Faced with enormous challenges around healthcare reform, models create frameworks for practice by unifying, uniting, and guiding our nurses. The Kaiser Permanente Practice model was developed to ensure consistency for nursing practice across the continuum. Four key pillars support this practice model and the work of nursing: quality and safety, leadership, professional development, and research/evidence-based practice. These four pillars form the foundation that makes transformational practice possible and aligns nursing with Kaiser Permanente's mission. The purpose of this article is to discuss the pillar of professional development and the components of the Nursing Professional Development: Scope and Standards of Practice model (American Nurses Association & National Nursing Staff Development Organization, 2010) and place them in a five-level development framework. This process allowed us to identify the current organizational level of practice, prioritize each nursing professional development component, and design an operational strategy to move nursing professional development toward a level of high performance. This process is suggested for nursing professional development specialists.

Impact of Professional Development on Level of Technology Integration in the Elementary Classroom

Science.gov (United States)

Miktuk, Darlynda

2012-01-01

The purpose of the quantitative study was to evaluate the impact of professional development on the level of technology integration within the elementary classroom using an online survey known as the LoTi (levels of teaching innovation) survey. Information about the history of computers, technology integration, andragogy, and effective…

The development of a prototype level-three interoperable catalog system

Science.gov (United States)

Hood, Carroll A.; Howie, Randy; Verhanovitz, Rich

1993-08-01

The development of a level-three interoperable catalog system is defined by a new paradigm for metadata access. The old paradigm is characterized by a hierarchy of metadata layers, the transfer of control to target systems, and the requirement for the user to be familiar with the syntax and data dictionaries of several catalog system elements. Attributes of the new paradigm are exactly orthogonal: the directory and inventories are peer entities, there is a single user interface, and the system manages the complexity of interacting transparently with remote elements. We have designed and implemented a prototype level-three interoperable catalog system based on the new paradigm. Through a single intelligent interface, users can interoperably access a master directory, inventories for selected satellite datasets, and an in situ meteorological dataset inventory. This paper describes the development of the prototype system and three of the formidable challenges that were addressed in the process. The first involved the interoperable integration of satellite and in situ inventories, which to our knowledge, has never been operationally demonstrated. The second was the development of a search strategy for orbital and suborbital granules which preserves the capability to identify temporally or spatially coincident subsets between them. The third involved establishing a method of incorporating inventory-specific search criteria into user queries. We are working closely with selected science data users to obtain feedback on the system's design and performance. The lessons learned from this prototype will help direct future development efforts. Distributed data systems of the 1990s such as EOSDIS and the Global Change Data and Information System (GCDIS) will be able to build on this prototype.

Development of new low level radioactive waste disposal sites: A progress report

International Nuclear Information System (INIS)

Anderson, Robert T.; Antonucci, George J.; Ryan, Michael T.

1992-01-01

The status of the development of three new low level radioactive waste disposal facilities for the Central Midwest (Illinois), Southeastern (North Carolina) and Appalachian (Pennsylvania) compacts is presented. These three sites will dispose of about 50-65 percent of the commercial low-level waste (LLW) generated in the U.S. annually. Chem-Nuclear, as developer and proposed operator of all three sites has used a common approach to site development. This approach has been based on their twenty-plus years of operating experience and a standard technical approach. The technology employed is an above-grade, multiple engineered barrier design. The paper also contrasts actual progress at each site with a generalized project schedule. Areas of schedule delays are noted along with the steps being taken to accelerate schedule. Finally, we note that continued progress and timely start-up of operations of these new sites is critical on a national basis. This is due to the possibility of near-term closure of the existing LLW disposal sites. (author)

The Evolution of the Research - Development Services at the Regional Level in Romania

Directory of Open Access Journals (Sweden)

Cecilia-Irina RĂBONȚU

2017-12-01

Full Text Available Research and Development services are the first of the services that support the process of innovation, innovation, and eco-innovation, with a special attention from developing countries that invest a significant percentage of GDP in these type of services. Studying the evolution of R & D services in the territorial profile is a major issue in the current context because these services are the first step in any stage of innovation, development, competitiveness, raising the standard of living of the population, increasing the economic well-being and social issues of a country. The purpose of this paper is to review the literature in the field and to analyze the evolution of the main relevant indicators in describing the level at which R & D services in Romania, and at the regional level, indicators for which there are publicly available statistical data in the official databases. The study, based on fundamental research in the field and the results of numerous bibliographic sources on this topic, uses specific statistical methods of territorial analysis. The obtained results outline an overview of the research and development services in Romania, but also at the level of the NUTS2 regions highlighting the gaps between them.

Costs and benefits of multiple levels of models in MDA development

NARCIS (Netherlands)

Andrade Almeida, João; Akehurst, D.H.; Ferreira Pires, Luis; van Sinderen, Marten J.

In Model-Driven Architecture (MDA) development, models of a distributed application are carefully defined so as to remain stable in face of changes in technology platforms. As we have argued previously in [1, 3], models in MDA can be organized into different levels of platformindependence. In this

INTEGRATION OF SUSTAINABLE DEVELOPMENT AND QUALITY ON ORGANISATIONAL AND REGIONAL LEVEL

Directory of Open Access Journals (Sweden)

Aleksandra Kokic Arsic

2016-09-01

Full Text Available Subject of the article is an integration of quality management and sustainable development, with the basis of considerations of sustainable development and the structure of the key quality factors pointed to the possibility of achieving synergy of action on the most important variables, as well as the established model of integration of these two complex concepts. Areas of our study were 83 organizations in the region of Central Serbia. The study was based on questionnaires which contained 50 questions about the level of quality and sustainable development in the companies surveyed. Results of research highlights the most influenced variables in condition of constraints related to transition economy characteristics.

THE CRITERIA, INDEXES AND LEVELS OF TEACHER'S OF NATURAL AND MATHEMATICS SUBJECTS INFORMATION COMPETENCE DEVELOPMENT

Directory of Open Access Journals (Sweden)

Petro Grabovskiy

2015-10-01

Full Text Available Submitted research depends on an actual problem – how is necessary to identify means of teacher's of general education information competence evaluation. In particular, there developed on an evaluation criteria of teacher's of Natural and Mathematics subjects information competence – motivational, cognitive-operating, reflexive; and decomposition to appropriated performance criterion made in this research too. With the help of empirical research methods, in particular the method of expert evaluations, using methods of relative frequency selection, determing by an expert's performance and relevant criteria, proved significance when evaluation of teacher's of Natural and Mathematics subjects information competence development is appropriated. Based on the grounded and developed criteria and relevant indicators where four levels of studing teacher's information competence development were describing – low, middle, sufficient and high levels. According to an author opinion, the further research may be concern with the help of mathematical tools development to determine the level of teacher's of Natural and Mathematics subjects information competence development based on the selected criteria and relevant indicators

The Bidirectional Causality between Country-Level Governance, Economic Growth and Sustainable Development: A Cross-Country Data Analysis

Directory of Open Access Journals (Sweden)

Cristina Boţa-Avram

2018-02-01

Full Text Available In the context of contemporary society, characterized by the information users’ growing and differentiated needs, the way country-level governance and social responsibility contribute to the ensuring of sustainable economic development is a concern for all the actors of the economic sphere. The aim of this paper is to test the causal linkages between the quality of country-level governance, economic growth and a well-known indicator of economic sustainable development, for a large panel of world-wide countries for a period of 10 years (2006–2015. While there are some prior studies that have argued the bidirectional causality between good public governance and economic development, this study intends to provide a new focus on the relationship between country-level governance and economic growth, on one hand, and between country-level governance and adjusted net savings, as a selected indicator of economic sustainable development, on the other hand. Four hypotheses on the causal relationship between good governance, economic growth and sustainable development were tested by using Granger non-causality tests. Our findings resulting from Granger non-causality tests provide reasonable evidence of Granger causality from country-level governance to economic growth, but from economic growth to country-level governance, the causality is not confirmed. In what regards the relationship between country-level governance and adjusted net savings, the bidirectional Granger causality is not confirmed. The main implication of our study is that improving economic growth and sustainable development is a very challenging issue, and the impact of macro-level factors such as country-level governance should not be neglected.

"Economic Development, Income Inequality and Social Stability in Prewar Japan: A Prefecture-level Analysis"

OpenAIRE

Tetsuji Okazaki

2007-01-01

This paper addresses the relationship between economic development, income inequality and social stability, using the data of prewar Japan. We have made prefecture-level income inequality index, based on tax and wage statistics with respect to four data points, 1888, 1896, 1921 and 1935. Regression analyses of the prefecture-level panel data confirmed that there was an inverse-U shaped relationship between economic development and income inequality. At the same time thorough analyses of the d...

Assessment of the level of development of insurance of agricultural enterprises in Ukrainian regions

Directory of Open Access Journals (Sweden)

Ostapenko Olga N.

2013-03-01

Full Text Available The article considers application of the taxonomic analysis for identifying the level of development of insurance of agricultural enterprises (in case of its voluntary form in Ukrainian regions through calculation of the taxonomy ratio (development level ratio. On the basis of the conducted study the author identifies those regions of Ukraine where the level of development of insurance of agricultural enterprises, in particular, their agricultural products, is characterised with positive dynamics and those regions where the tariff policy of insurance companies needs to be reconsidered. That is why the article justifies a necessity of replacing the existing tariff policy of insurance companies with a more suitable for modern conditions of farming with the aim to ensure, on the one hand, organisation of efficient management of an insurance company and, on the other hand, taking into account interests and requirements of agricultural enterprises, which are reflected in insurance tariffs.

Analyzing the Role of Multi-level Learning in Implementing computerized HIS in Developing Countries

DEFF Research Database (Denmark)

Mengiste, Shegaw Anagaw

2008-01-01

This paper presents a perspective for looking at the development and implementation of large scale computerised HIS as a multi-level learning process. Drawing on the empirical evidences from the ongoing Health Information systems program ( HISP) initiatives on the development, customization...... and implementation of computerised HIS in Ethiopia, the paper analyses the learning mechanisms, learning outcomes and obstacles for learning at individual, group, and organizational levels. Empirical data on two distinct phases of software development and customization (District health Information Software (DHIS......) versions 1.3 and 2.0) are contrasted. More specifically, we tried to show the dynamics of learning and the specific learning mechanisms by analysing and contrasting the interaction between IS developers and public health care domain experts, technological capacity at individual, group, and organizational...

Efecto de una sola dosis de ácido zoledrónico en un caso de enfermedad de Paget ósea

Directory of Open Access Journals (Sweden)

Melina Sabán

2010-10-01

Full Text Available La enfermedad de Paget es un trastorno crónico del remodelado óseo, caracterizado por un aumento de la resorción ósea producido por osteoclastos atípicos, seguido por un incremento acelerado de la formación ósea, lo que resulta en la formación de hueso en mosaico desorganizado. Un excelente marcador bioquímico para orientar el diagnóstico y seguimiento es la fosfatasa alcalina (FAL. Se presenta el caso de un paciente de 90 años, de sexo masculino, con diagnóstico de enfermedad de Paget. Se inicia tratamiento con pamidronato vía oral con respuesta parcial, por lo que se rota a pamidronato endovenoso. Disminuyen el dolor y la concentración plasmática de FAL, persistiendo con centellograma óseo patológico. Luego de varios años de tratamiento, con adecuado aporte de calcio y vitamina D, comienza nuevamente con dolor y valores elevados de FAL. Se decide iniciar tratamiento con ácido zoledrónico endovenoso 4 mg, única aplicación, obteniéndose remisión clínica y bioquímica desde hace cuatro años y mejoría de la imagen centellográfica. Este informe refiere la buena respuesta, sostenida en el tiempo, al tratamiento con única dosis de ácido zoledrónico en un paciente que presentó resistencia al pamidronato.

Development of digital low level rf system

International Nuclear Information System (INIS)

Michizono, Shinichiro; Anami, Shozo; Katagiri, Hiroaki; Fang, Zhigao; Matsumoto, Toshihiro; Miura, Takako; Yano, Yoshiharu; Yamaguchi, Seiya; Kobayashi, Tetsuya

2008-01-01

One of the biggest advantages of the digital low level rf (LLRF) system is its flexibility. Owing to the recent rapid progress in digital devices (such as ADCs and DACs) and telecommunication devices (mixers and IQ modulators), digital LLRF system becomes popular in these 10 years. The J-PARC linac LLRF system adopted cPCI crates and FPGA based digital feedback system. Since the LLRF control of the normal conducting cavities are more difficult than super conducting cavities due to its lower Q values, fast processing using the FPGA was the essential to the feedback control. After the successful operation of J-PARC linac LLRF system, we developed the STF (ILC test facility in KEK) LLRF system. Since the klystron drives eight cavities in STF phase 1, we modified the FPGA board. Basic configuration and the performances of these systems are summarized. The future R and D projects (ILC and ERL) is also described from the viewpoints of LLRF. (author)

The CMS High Level Trigger System: Experience and Future Development

CERN Document Server

Bauer, Gerry; Bowen, Matthew; Branson, James G; Bukowiec, Sebastian; Cittolin, Sergio; Coarasa, J A; Deldicque, Christian; Dobson, Marc; Dupont, Aymeric; Erhan, Samim; Flossdorf, Alexander; Gigi, Dominique; Glege, Frank; Gomez-Reino, R; Hartl, Christian; Hegeman, Jeroen; Holzner, André; Y L Hwong; Masetti, Lorenzo; Meijers, Frans; Meschi, Emilio; Mommsen, R K; O'Dell, Vivian; Orsini, Luciano; Paus, Christoph; Petrucci, Andrea; Pieri, Marco; Polese, Giovanni; Racz, Attila; Raginel, Olivier; Sakulin, Hannes; Sani, Matteo; Schwick, Christoph; Shpakov, Dennis; Simon, M; Spataru, A C; Sumorok, Konstanty

2012-01-01

The CMS experiment at the LHC features a two-level trigger system. Events accepted by the first level trigger, at a maximum rate of 100 kHz, are read out by the Data Acquisition system (DAQ), and subsequently assembled in memory in a farm of computers running a software high-level trigger (HLT), which selects interesting events for offline storage and analysis at a rate of order few hundred Hz. The HLT algorithms consist of sequences of offline-style reconstruction and filtering modules, executed on a farm of 0(10000) CPU cores built from commodity hardware. Experience from the operation of the HLT system in the collider run 2010/2011 is reported. The current architecture of the CMS HLT, its integration with the CMS reconstruction framework and the CMS DAQ, are discussed in the light of future development. The possible short- and medium-term evolution of the HLT software infrastructure to support extensions of the HLT computing power, and to address remaining performance and maintenance issues, are discussed.

SPACE PHYSICS: Developing resources for astrophysics at A-level: the TRUMP Astrophysics project

Science.gov (United States)

Swinbank, Elizabeth

1997-01-01

After outlining the astrophysical options now available in A-level physics syllabuses, this paper notes some of the particular challenges facing A-level teachers and students who chose these options and describes a project designed to support them. The paper highlights some key features of the project that could readily be incorporated into other areas of physics curriculum development.

Dominant Indicators of Bank Crises: Comparative Analysis for States with Different Levels of Economic Development

Directory of Open Access Journals (Sweden)

Kozlov Vladislav I.

2014-03-01

Full Text Available The article is devoted to identification of common and distinctive regularities of development of banking systems with different levels of development of economy through study of the most important macro-economic and financial indicators. The article uses instruments of the applied statistics. The study is based on comparison of mean values of indicators in two groups of countries (countries with a high level of income and countries with a medium level of income, each of which is divided into two sub-groups based on whether there was banking crisis in 2008 or not. In the result of the study the article shows that there are both common and distinctive features of development of banking systems of countries with different levels of economic development. Thus, a typical scenario, characteristic for countries with developed economy that had banking crisis in 2008, includes availability of a relatively large-scale crediting of the economy under conditions of relatively low rates of economic growth and close connections of the national banking systems with banking systems of other countries. Development of banking systems of developing countries during the pre-crisis period is characterised with the following specific features: relatively high rates of growth of scales of crediting of the economy and high rates of economic growth under conditions of use of significant volumes of resources, borrowed in financial markets, and close connection of the national banking systems with banking systems of other countries. The study allows a more efficient use of experience of states with developed economy, since the described results give a possibility to adjust experience of other states, taking into account characteristic features of banking systems of developing countries. Also the study identified states, experience of which should be studied. The conducted analysis of interrelations of indicators could be used for building models of assessment of

Mutations in FUS cause FALS and SALS in French and French Canadian populations.

Science.gov (United States)

Belzil, V V; Valdmanis, P N; Dion, P A; Daoud, H; Kabashi, E; Noreau, A; Gauthier, J; Hince, P; Desjarlais, A; Bouchard, J-P; Lacomblez, L; Salachas, F; Pradat, P-F; Camu, W; Meininger, V; Dupré, N; Rouleau, G A

2009-10-13

The identification of mutations in the TARDBP and more recently the identification of mutations in the FUS gene as the cause of amyotrophic lateral sclerosis (ALS) is providing the field with new insight about the mechanisms involved in this severe neurodegenerative disease. To extend these recent genetic reports, we screened the entire gene in a cohort of 200 patients with ALS. An additional 285 patients with sporadic ALS were screened for variants in exon 15 for which mutations were previously reported. In total, 3 different mutations were identified in 4 different patients, including 1 3-bp deletion in exon 3 of a patient with sporadic ALS and 2 missense mutations in exon 15 of 1 patient with familial ALS and 2 patients with sporadic ALS. Our study identified sporadic patients with mutations in the FUS gene. The accumulation and description of different genes and mutations helps to develop a more comprehensive picture of the genetic events underlying amyotrophic lateral sclerosis.

Significant progress towards development of the low-level radioactive waste disposal facility in Illinois

International Nuclear Information System (INIS)

Klebe, M.; Henry, T.L.; Corpstein, P.

1996-01-01

Development of disposal sites for low-level radioactive waste is a complicated legal, regulatory and public sector process. Development of the low-level radioactive waste disposal facility to support generators in Illinois and Kentucky is well under way. Significant progress has been made to re-engineer the siting development process capitalizing on prior lessons learned and a recommitment from Illinois state leadership assuring the future success of the program. Comparisons of why this new process will succeed are the major focus of this paper. Specific changes in approach from the previous process including changes in the Illinois Management Act (Management Act), creation of the Illinois Low-Level Radioactive Waste Siting Task Group (Task Group), new roles for the Illinois State Geologic Survey and Illinois State Water Survey (Scientific Surveys) and the Illinois Department of Nuclear Safety (IDNS), a new contractor reliance approach and increased confidence on the open-quote science close-quote are the major contrasts between the previous process and the new process currently underway

Developing micro-level urban ecosystem indicators for sustainability assessment

Energy Technology Data Exchange (ETDEWEB)

Dizdaroglu, Didem, E-mail: dizdaroglu@bilkent.edu.tr

2015-09-15

Sustainability assessment is increasingly being viewed as an important tool to aid in the shift towards sustainable urban ecosystems. An urban ecosystem is a dynamic system and requires regular monitoring and assessment through a set of relevant indicators. An indicator is a parameter which provides information about the state of the environment by producing a quantitative value. Indicator-based sustainability assessment needs to be considered on all spatial scales to provide efficient information of urban ecosystem sustainability. The detailed data is necessary to assess environmental change in urban ecosystems at local scale and easily transfer this information to the national and global scales. This paper proposes a set of key micro-level urban ecosystem indicators for monitoring the sustainability of residential developments. The proposed indicator framework measures the sustainability performance of urban ecosystem in 3 main categories including: natural environment, built environment, and socio-economic environment which are made up of 9 sub-categories, consisting of 23 indicators. This paper also describes theoretical foundations for the selection of each indicator with reference to the literature [Turkish] Highlights: • As the impacts of environmental problems have multi-scale characteristics, sustainability assessment needs to be considered on all scales. • The detailed data is necessary to assess local environmental change in urban ecosystems to provide insights into the national and global scales. • This paper proposes a set of key micro-level urban ecosystem indicators for monitoring the sustainability of residential developments. • This paper also describes theoretical foundations for the selection of each indicator with reference to the literature.

Stakeholders' perceptions on competency and assessment program of entry-level pharmacists in developing countries.

Science.gov (United States)

Asante, Isaac; Andoh, Irene; Muijtjens, Arno M M; Donkers, Jeroen

2017-05-01

To assess the stakeholders' perceptions on the competency of entry-level pharmacists and the use of written licensure examination as the primary assessment for licensure decisions on entry-level pharmacists who have completed the Pharmacy Internship Program 1 (PIP) in developing countries. A cross-sectional survey was conducted among stakeholders in which they completed a web-based 21-item pre-tested questionnaire to determine their views regarding the competency outcomes and assessment program for entry-level pharmacist. The stakeholders rated the entry-level pharmacists to possess all competencies except research skills. Stakeholders suggested improvement of the program by defining the competency framework and training preceptors. However, stakeholders disagree on using written examination as the primary assessment for licensure decision and suggested the incorporation of other performance-based assessments like preceptor's assessment reports. Stakeholders are uncertain on entry-level pharmacists in developing countries possessing adequate research competencies and think their assessment program for licensure need more than written examination to assess all required competencies. Copyright © 2017 Elsevier Inc. All rights reserved.

Bundesforschungsanstalt fuer Landwirtschaft Braunschweig-Voelkenrode (FAL). Annual report 1987

International Nuclear Information System (INIS)

1988-01-01

The tasks of the Bundesforschungsanstalt in the field of agricultural science and related sciences include research, the publication of scientific results, and the fostering of international cooperation with scientists and institutions. In the area preservation and optimization of the quality of soil, plant production and animal breeding, the objectives are also to record and evaluate alien and harmful substances, including radioactive materials, in agrarian ecosystems. Furthermore, investigations are carried through on the avoidance of health-endangering effects and hazards for farm-workers involving the risk of accidents. (ECB) [de

The development and use of decision aiding techniques for establishing intervention levels

International Nuclear Information System (INIS)

Kelly, G.N.; Sinnaeve, J.

1989-01-01

Following the Chernobyl accident there has been considerable international discussion on the principles underlying the choice of intervention levels and their practical application. While there is broad agreement on the underlying principles - that is to put potentially exposed individuals into a better position in the sense that lower overall risks are achieved at reasonable cost in financial and social terms - the determination of what constitutes the most appropriate type and level of intervention in any particular circumstances is more complex. Within the CEC Radiation Protection Research Programme techniques are being developed to aid well founded and more transparent decisions on the choice of intervention levels. The techniques are described and areas identified where they might usefully be applied

Exploring talent development environments –inspirations to medical education at doctoral level

DEFF Research Database (Denmark)

Christensen, Mette Krogh; Lund, Ole; Mørcke, Anne Mette

Introduction: Doctoral students may be considered some of our most talented students. In order to maintain high quality in doctoral education we should be aware of optimizing the talent development environment in which the students develop their competencies. In this paper we explore the features...... has been on cognitive skills of individual talents and to a minor degree on institutional conditions and constraints within talent development environments. However, recent studies on talent development in sport recognize ‘talent’ as a social construction (1) and institutional and environmental...... features playing a decisive role in talent development (2). Our research question is: do concepts and models for talent development environments in sport apply to medical education at doctoral level? Considering the uniqueness of the two domains (they refer to different overall social fields: education...

Development of Human-level Decision Making Algorithm for NPPs through Deep Neural Networks : Conceptual Approach

International Nuclear Information System (INIS)

Kim, Seung Geun; Seong, Poong Hyun

2017-01-01

Development of operation support systems and automation systems are closely related to machine learning field. However, since it is hard to achieve human-level delicacy and flexibility for complex tasks with conventional machine learning technologies, only operation support systems with simple purposes were developed and high-level automation related studies were not actively conducted. As one of the efforts for reducing human error in NPPs and technical advance toward automation, the ultimate goal of this research is to develop human-level decision making algorithm for NPPs during emergency situations. The concepts of SL, RL, policy network, value network, and MCTS, which were applied to decision making algorithm for other fields are introduced and combined with nuclear field specifications. Since the research is currently at the conceptual stage, more research is warranted.

Survey and analysis of the domestic technology level for the concept development of high level waste disposal

Energy Technology Data Exchange (ETDEWEB)

Kang, Chang Sun; Kim, Byung Su; Song, Jae Hyok [Seoul National University, Seoul (Korea); Park, Kwang Hon; Hwang, Ju Ho; Park, Sung Hyun; Lee, Jae Min [Kyunghee University, Seoul (Korea); Han, Joung Sang; Kim, Ku Young [Yonsei University, Seoul (Korea); Lee, Jae Ki; Chang, Jae Kwon [Hangyang University, Seoul (Korea)

1998-09-01

The objectives of this study are the analysis of the status of HLW disposal technology and the investigation of the domestic technology level. The study has taken two years to complete with the participation of forty five researchers. The study was mainly carried out through means of literature surveys, collection of related data, visits to research institutes, and meetings with experts in the specific fields. During the first year of this project, the International Symposium on the Concept Development of the High Level Waste Disposal System was held in Taejon, Korea in October, 1997. Eight highly professed foreign experts whose fields of expertise projected to the area of high level waste disposal were invited to the symposium. This study is composed of four major areas; disposal system design/construction, engineered barrier characterization, geologic environment evaluation and performance assessment and total safety. A technical tree scheme of HLW disposal has been illustrated according to the investigation and an analysis for each technical area. For each detailed technology, research projects, performing organization/method and techniques that are to be secured in the order of priority are proposed, but the suggestions are merely at a superfluous level of propositional idea due to the reduction of the budget in the second year. The detailed programs on HLW disposal are greatly affected by governmental HLW disposal policy and in this study, the primary decisions to be made in each level of HLW disposal enterprise and a rough scheme are proposed. (author). 20 refs., 97 figs., 33 tabs.

Community level composting in a developing country: case study of KIWODET, Tanzania

NARCIS (Netherlands)

Oberlin, A.S.; Szanto, G.L.

2011-01-01

Environmentally sustainable waste management practices have a limited relevance and viability in developing countries. Despite a technological potential, composting initiatives often share this fate. Little is known about the functioning of community level composting, which is reportedly the optimal

Evaluation of cement treated base courses : technical assistance report.

Science.gov (United States)

2000-12-01

The objectives of this project are to determine the strength characteristics of soil cement bases that were constructed under stabilized procedures (DOTD TR 432M/432-99) and the cement treated design philosophy. This was accomplished by using the Fal...

Management Development Programs: The Effects of Management Level and Corporate Strategy. [and] Invited Reaction: Level and Strategy Should and Do Make a Difference!

Science.gov (United States)

Blakely, Gerald L.; And Others

1994-01-01

Consensus of survey responses from 155 of 600 human resource managers was as follows: management development programs emphasized technical skills at lower levels, entrepreneurial skills at senior levels; organizations with corporate growth strategies focused on more areas than those with stability or retrenchment strategies. (Muschewske's reaction…

The Development of a Team Empowerment Program in Schools at the Basic Education Level

Directory of Open Access Journals (Sweden)

Sakda Khamso

2017-03-01

Full Text Available The purpose of this research was to develop a Team Empowerment Program (TEP in Schools at the Basic Education Level (SBEL. The research methodology used in this study was research and development with four phases: 1 investigating actual state and desirable state with regard to team empowerment in SBEL; 2 developing a TEP in SBEL; 3 trying out on the implementation of the developed program in a sample school; and 4 assessing a use of the developed program. The sample consisted of 120 teachers of Chakkaratwittaya School in Nakhon-Ratchasima Province. The instruments used in this study were a set of questionnaires, a set of interview questions, an evaluation form and meeting minutes. The statistics used in the data analysis included percentage, mean ( , standard deviation (S.D., and priority needs index (PNI. The Conclusions were: 1. The current situation of team empowerment in SBEL both at the overall and individual levels indicates a low level of practice. In contrast, the highest level of team empowerment has been found under the most desirable conditions. 2. The developed TEP was comprised of: 1 rationale; 2 objectives and target; 3 content of teachers’ training included 6 aspects: 3.1 improving the administrative structure, 3.2 building a working system, 3.3 building work collaborations, 3.4 building the work environment, 3.5 building motivation to work, and 3.6 building the culture of work; 4 method of development used with intervention process which comprised 3 modules: 4.1 meetings to build awareness, 4.2 meetings to diagnose the relevant situations, and 4.3 meetings to appoint a problem-solving team; and 5 evaluation. 3. The results of the mplementation of the TEP in Chakkaratwittaya School were: 3.1 After the implementation of the developed program the teamwork behaviors of the teachers in each learning area group were significantly higher than before the implementation, with a statistical significance level of 0.1. 3.2 The overall

Community Vitality: The Role of Community-Level Resilience Adaptation and Innovation in Sustainable Development

Directory of Open Access Journals (Sweden)

Lenore Newman

2010-01-01

Full Text Available Community level action towards sustainable development has emerged as a key scale of intervention in the effort to address our many serious environmental issues. This is hindered by the large-scale destruction of both urban neighbourhoods and rural villages in the second half of the twentieth century. Communities, whether they are small or large, hubs of experimentation or loci of traditional techniques and methods, can be said to have a level of community vitality that acts as a site of resilience, adaptation and innovation in the face of environmental challenges. This paper outlines how community vitality acts as a cornerstone of sustainable development and suggests some courses for future research. A meta-case analysis of thirty-five Canadian communities reveals the characteristics of community vitality emerging from sustainable development experiments and its relationship to resilience, applied specifically to community development.

Development of nanosensors for studying intracellular phosphate levels

DEFF Research Database (Denmark)

Gu, Hong

-time monitoring of Pi metabolism in living cells, providing a new tool for fluxomics (measurement of metabolic flux), analysis of pathophysiology or changes of Pi during cell activity. Transformation of plants with FLIPs had resulted in only low expression levels. As an alternative a protein transduction domain......Abstract Inorganic phosphate (Pi) is an essential macronutrient that plays a central role in metabolism and signal transduction in plants. Uptake, compartmentation and transport are important players of cellular Pi homeostasis; however, methods to determine the cellular phosphate concentration...... of a substrate-binding protein linked to two fluorescent reporter proteins. Substrate binding changes the conformation of the nanosensor and, hence, the efficiency of fluorescence resonance energy transfer (FRET) between the reporter proteins. The aim of the present project was to develop nanosensors for Pi...

Development of capacitive sensor for automatically measuring tumbler water level with FEA simulation.

Science.gov (United States)

Wei, Qun; Kim, Mi-Jung; Lee, Jong-Ha

2018-01-01

Drinking water has several advantages that have already been established, such as improving blood circulation, reducing acid in the stomach, etc. However, due to people not noticing the amount of water they consume every time they drink, most people drink less water than the recommended daily allowance. In this paper, a capacitive sensor for developing an automatic tumbler to measure water level is proposed. Different than in previous studies, the proposed capacitive sensor was separated into two sets: the main sensor for measuring the water level in the tumbler, and the reference sensor for measuring the incremental level unit. In order to confirm the feasibility of the proposed idea, and to optimize the shape of the sensor, a 3D model of the capacitive sensor with the tumbler was designed and subjected to Finite Element Analysis (FEA) simulation. According to the simulation results, the electrodes were made of copper and assembled in a tumbler manufactured by a 3D printer. The tumbler was filled with water and was subjected to experiments in order to assess the sensor's performance. The comparison of experimental results to the simulation results shows that the measured capacitance value of the capacitive sensor changed linearly as the water level varied. This proves that the proposed sensor can accurately measure the water level in the tumbler. Additionally, by use of the curve fitting method, a compensation algorithm was found to match the actual level with the measured level. The experimental results proved that the proposed capacitive sensor is able to measure the actual water level in the tumbler accurately. A digital control part with micro-processor will be designed and fixed on the bottom of the tumbler for developing a smart tumbler.

Developing operating procedures for a low-level radioactive waste disposal facility

Energy Technology Data Exchange (ETDEWEB)

Sutherland, A.A.; Miner, G.L.; Grahn, K.F.; Pollard, C.G. [Rogers and Associates Engineering Corp., Salt Lake City, UT (United States)

1993-10-01

This document is intended to assist persons who are developing operating and emergency procedures for a low-level radioactive waste disposal facility. It provides 25 procedures that are considered to be relatively independent of the characteristics of a disposal facility site, the facility design, and operations at the facility. These generic procedures should form a good starting point for final procedures on their subjects for the disposal facility. In addition, this document provides 55 annotated outlines of other procedures that are common to disposal facilities. The annotated outlines are meant as checklists to assist the developer of new procedures.

Developing operating procedures for a low-level radioactive waste disposal facility

International Nuclear Information System (INIS)

Sutherland, A.A.; Miner, G.L.; Grahn, K.F.; Pollard, C.G.

1993-10-01

This document is intended to assist persons who are developing operating and emergency procedures for a low-level radioactive waste disposal facility. It provides 25 procedures that are considered to be relatively independent of the characteristics of a disposal facility site, the facility design, and operations at the facility. These generic procedures should form a good starting point for final procedures on their subjects for the disposal facility. In addition, this document provides 55 annotated outlines of other procedures that are common to disposal facilities. The annotated outlines are meant as checklists to assist the developer of new procedures

A Influência da autorregulação nas heurísticas e vieses utilizados no processo de tomada de decisão [doi: 10.5329/RECADM.2014026

Directory of Open Access Journals (Sweden)

Fábio Pimenta de Pádua Júnior

2014-12-01

Full Text Available Entre as diferentes teorias heurísticas que visam explicar o processo decisório, este estudo explora a falácia do jogador e a teoria da mão-quente. O objetivo deste artigo é investigar a influência da autorregulação afetiva nas heurísticas e vieses utilizados no processo de tomada de decisão. Foram realizados dois experimentos. No primeiro, foi avaliado se os resultados anteriores de ganhos com ações de empresas afetavam a preferência dos consumidores pela compra ou venda dessas ações. Constatou-se diferença entre gêneros no processo decisório, com a ocorrência da falácia do jogador para a amostra masculina, mas não para a amostra feminina. O segundo experimento foi realizado com o intuito de verificar o papel da autorregulação nestas heurísticas. Após a indução de autorregulação, observou-se a ocorrência da falácia do jogador e o viés da mão quente em algumas condições, indicando alterações nas decisões tomadas pelos consumidores. A partir desses resultados, conclui-se que há uma influência significativa do estado afetivo nas tomadas de decisão e que as mulheres são menos suscetíveis à falácia do jogador do que os homens. Keywords Autorregulação; tomada de decisão; falácia do jogador; teoria da mão quente.     THE INFLUENCE OF SELF-REGULATION IN HEURISTICS AND BIASES USED IN CONSUMER DECISION MAKING   RESUMO Among the different heuristics theories that attempt to explain the decision making process, this study explores the gambler's fallacy and the hot hand theory. This paper investigates the influence of self-regulation in heuristics and biases used during consumer decision making. Two experiments were conducted. The first one assessed if results of past performance of stocks affected consumer preference to buy or sell those stocks. Results indicated a significant difference between gender in decision making, with the occurrence of the gambler's fallacy for the male sample, but not for the

Mapping organism expression levels at cellular resolution in developing Drosophila

Science.gov (United States)

Knowles, David W.; Keranen, Soile; Biggin, Mark D.; Sudar, Damir

2002-05-01

The development of an animal embryo is orchestrated by a network of genetically determined, temporal and spatial gene expression patterns that determine the animals final form. To understand such networks, we are developing novel quantitative optical imaging techniques to map gene expression levels at cellular and sub-cellular resolution within pregastrula Drosophila. Embryos at different stages of development are labeled for total DNA and specific gene products using different fluorophors and imaged in 3D with confocal microscopy. Innovative steps have been made which allow the DNA-image to be automatically segmented to produce a morphological mask of the individual nuclear boundaries. For each stage of development an average morphology is chosen to which images from different embryo are compared. The morphological mask is then used to quantify gene-product on a per nuclei basis. What results is an atlas of the relative amount of the specific gene product expressed within the nucleus of every cell in the embryo at the various stages of development. We are creating a quantitative database of transcription factor and target gene expression patterns in wild-type and factor mutant embryos with single cell resolution. Our goal is to uncover the rules determining how patterns of gene expression are generated.

cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.

Directory of Open Access Journals (Sweden)

Yijin Tao

Full Text Available The development of myopia is associated with decreased ocular scleral collagen synthesis in humans and animal models. Collagen synthesis is, in part, under the influence of cyclic adenosine monophosphate (cAMP. We investigated the associations between cAMP, myopia development in guinea pigs, and collagen synthesis by human scleral fibroblasts (HSFs. Form-deprived myopia (FDM was induced by unilateral masking of guinea pig eyes. Scleral cAMP levels increased selectively in the FDM eyes and returned to normal levels after unmasking and recovery. Unilateral subconjunctival treatment with the adenylyl cyclase (AC activator forskolin resulted in a myopic shift accompanied by reduced collagen mRNA levels, but it did not affect retinal electroretinograms. The AC inhibitor SQ22536 attenuated the progression of FDM. Moreover, forskolin inhibited collagen mRNA levels and collagen secretion by HSFs. The inhibition was reversed by SQ22536. These results demonstrate a critical role of cAMP in control of myopia development. Selective regulation of cAMP to control scleral collagen synthesis may be a novel therapeutic strategy for preventing and treating myopia.

Consequences of moral Kohlberg´s moral development levels in higher education

OpenAIRE

Bordignon, Nelso Antonio

2011-01-01

Abstract Introduction. This article presents the results of a research work about the implications of Kohlberg´s moral development level in higher education. Objective. To identify the state of moral development among higher education teachers, departing from the orientation they give to their lives and to those of their students, and from what they think and say they do for their students´ moral education.With the results, an analysis is done in order to establish the impli...

Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals.

Directory of Open Access Journals (Sweden)

Karen I Maijer

Full Text Available We have previously shown that overweight may increase the risk of developing rheumatoid arthritis (RA in autoantibody positive individuals. Adipose tissue could contribute to the development of RA by production of various bioactive peptides. Therefore, we examined levels of adipokines in serum and synovial tissue of subjects at risk of RA.Fifty-one individuals positive for immunoglobulin M rheumatoid factor (IgM-RF and/or anti-citrullinated protein antibodies (ACPA, without arthritis, were included in this prospective study. Levels of adiponectin, vaspin, resistin, leptin, chemerin and omentin were determined in baseline fasting serum samples (n = 27. Synovial tissue was obtained by arthroscopy at baseline and we examined the expression of adiponectin, resistin and visfatin by immunohistochemistry.The development of clinically manifest arthritis after follow-up was associated with baseline serum vaspin levels (HR1.5 (95% CI 1.1 to 2.2; p = 0.020, also after adjustment for overweight (HR1.7 (95% CI 1.1 to 2.5; p = 0.016. This association was not seen for other adipokines. Various serum adipokine levels correlated with BMI (adiponectin r = -0.538, leptin r = 0.664; chemerin r = 0.529 and systemic markers of inflammation such as CRP levels at baseline (adiponectin r = -0.449, omentin r = -0.557, leptin r = 0.635, chemerin r = 0.619, resistin r = 0.520 and ESR (leptin r = 0.512, chemerin r = 0.708, p-value<0.05. Synovial expression of adiponectin, resistin and visfatin was not associated with development of clinically manifest arthritis.In this exploratory study, serum adipokines were associated with an increased inflammatory state in autoantibody-positive individuals at risk of developing RA. Furthermore, serum vaspin levels may assist in predicting the development of arthritis in these individuals.

Developing Curriculum of Nuclear Civil Engineering Degree Programme at Graduate Level

International Nuclear Information System (INIS)

Iqbal, J.

2016-01-01

Full text: The paper suggests the introduction of a new degree, namely nuclear civil engineering at graduate level for better utilization of civil engineers in nuclear power plant (NPP) design and construction. At present, both nuclear engineering and civil engineering degrees are offered at undergraduate and graduate levels in numerous renowned universities of the world. However, when a civil engineer, even after completion of nuclear engineering at postgraduate level, undertakes an assignment related to NPP design, he comes across various problems which are not covered in the present curricula. For instance, NPPs’ siting issues, design of pre-stressed concrete containment against loads of loss of coolant accident (LOCA), various impulsive and impactive loads (e.g., detonations, aircraft crash analysis, etc.) and shielding calculations are some of the core issues during nuclear power plant design. The paper highlights the importance of introduction of nuclear civil engineering degree at the graduate level. Besides, the contents of the proposed course work have also been discussed. Keeping in view the fact that, currently, no such degree is offered in any university of the world, the paper explores useful avenues to human resource development for introducing and expanding nuclear power programmes. (author

The Influence of Pelvic Incidence and Lumbar Lordosis Mismatch on Development of Symptomatic Adjacent Level Disease Following Single-Level Transforaminal Lumbar Interbody Fusion.

Science.gov (United States)

Tempel, Zachary J; Gandhoke, Gurpreet S; Bolinger, Bryan D; Khattar, Nicolas K; Parry, Philip V; Chang, Yue-Fang; Okonkwo, David O; Kanter, Adam S

2017-06-01

Annual incidence of symptomatic adjacent level disease (ALD) following lumbar fusion surgery ranges from 0.6% to 3.9% per year. Sagittal malalignment may contribute to the development of ALD. To describe the relationship between pelvic incidence-lumbar lordosis (PI-LL) mismatch and the development of symptomatic ALD requiring revision surgery following single-level transforaminal lumbar interbody fusion for degenerative lumbar spondylosis and/or low-grade spondylolisthesis. All patients who underwent a single-level transforaminal lumbar interbody fusion at either L4/5 or L5/S1 between July 2006 and December 2012 were analyzed for pre- and postoperative spinopelvic parameters. Using univariate and logistic regression analysis, we compared the spinopelvic parameters of those patients who required revision surgery against those patients who did not develop symptomatic ALD. We calculated the predictive value of PI-LL mismatch. One hundred fifty-nine patients met the inclusion criteria. The results noted that, for a 1° increase in PI-LL mismatch (preop and postop), the odds of developing ALD requiring surgery increased by 1.3 and 1.4 fold, respectively, which were statistically significant increases. Based on our analysis, a PI-LL mismatch of >11° had a positive predictive value of 75% for the development of symptomatic ALD requiring revision surgery. A high PI-LL mismatch is strongly associated with the development of symptomatic ALD requiring revision lumbar spine surgery. The development of ALD may represent a global disease process as opposed to a focal condition. Spine surgeons may wish to consider assessment of spinopelvic parameters in the evaluation of degenerative lumbar spine pathology. Copyright © 2017 by the Congress of Neurological Surgeons

In vitro development rate of preimplantation rabbit embryos cultured with different levels of melatonin.

Science.gov (United States)

Mehaisen, Gamal Mohamed Kamel; Saeed, Ayman Moustafa

2015-02-01

This study aimed to investigate the effect of melatonin supplementation at different levels in culture medium on embryo development in rabbits. Embryos of 2-4 cells, 8-16 cells and morula stages were recovered from nulliparous Red Baladi rabbit does by laparotomy technique 24, 48 and 72 h post-insemination, respectively. Normal embryos from each stage were cultured to hatched blastocyst stages in either control culture medium (TCM-199 + 20% fetal bovine serum) or control supplemented with melatonin at 10(-3) M, 10(-6) M or 10(-9) M. No effect of melatonin was found on development of embryos recovered at 24 h post-insemination. The high level of melatonin at 10(-3) M adversely affected the in vitro development rates of embryos recovered at 48 h post-insemination (52 versus 86, 87 and 80% blastocyst rate; 28 versus 66, 78 and 59% hatchability rate for 10(-3) M versus 10(-9) M, 10(-6) M and control, respectively, P< 0.05). At the morula stage, melatonin at 10-3 M significantly increased the in vitro development of embryos (92% for 10(-3) M versus 76% for control, P < 0.05), while the hatchability rate of these embryos was not improved by melatonin (16-30% versus 52% for melatonin groups versus control, P < 0.05). Results show that a moderate level of melatonin (10(-6) M) may improve the development and hatchability rates of preimplantation rabbit embryos. The addition of melatonin at a 10-3 M concentration enhances the development of rabbit morulae but may negatively affect the development of earlier embryos. More studies are needed to optimize the use of melatonin in in vitro embryo culture in rabbits.

Development of the liquid level meters for the PandaX dark matter detector

International Nuclear Information System (INIS)

Hu Jie; Gong Haowei; Lin Qing; Ni Kaixuan; Wei Yuehuan; Xiao Mengjiao; Xiao Xiang; Zhao Li; Tan Andi

2014-01-01

The two-phase xenon detector is at the frontier of dark matter direct search. This kind of detector uses liquid xenon as the sensitive target and is operated in two-phase (liquid/gas) mode, where the liquid level needs to be monitored and controlled in sub-millimeter precision. In this paper, we present a detailed design and study of two kinds of level meters for the PandaX dark matter detector. The long level meter is used to monitor the overall liquid level while short level meters are used to monitor the inclination of the detector. These level meters are cylindrical capacitors that are custom-made from two concentric metal tubes. Their capacitance values are read out by a universal transducer interface chip and are recorded by the PandaX slow control system. We present the developments that lead to level meters with long-term stability and sub-millimeter precision. Fluctuations (standard deviations) of less than 0.02 mm for the short level meters and less than 0.2 mm for the long level meter were achieved during a few days of test operation. (authors)

Sociólogo sentipensante

Directory of Open Access Journals (Sweden)

Renán Vega Cantor

2013-09-01

Full Text Available Antología. Orlando Fals Borda. José María Rojas Guerra (Prefacio. Universidad Nacional de Colombia, Vicerrectoría Académica, Instituto de Estudios Políticos y Relaciones Internacionales, Bogotá, 2010, 387 págs.

Experience in the development and practical use of working control levels for radiation safety

International Nuclear Information System (INIS)

Epishin, A.V.

1981-01-01

The experience of development and practical use of working control levels (WCL) of radiation safety in the Gorky region, is discussed. WCL are introduced by ''Radiation Safety Guides'' (RSG-76) and have great practical importance. Regional control levels of radiation safety are determined for certain types of operations implying radioactive hazard and differentiated according to the types of sources applied and types of operation. Dose rates, radioactive contamination of operating surfaces, skin, air and waste water are subject to normalization. Limits of individual radiation doses specified according to operation categories are included. 10 tables of regional WCL indices are developed [ru

The influence of economic development level, household wealth and maternal education on child health in the developing world.

Science.gov (United States)

Boyle, Michael H; Racine, Yvonne; Georgiades, Katholiki; Snelling, Dana; Hong, Sungjin; Omariba, Walter; Hurley, Patricia; Rao-Melacini, Purnima

2006-10-01

This study estimates the relative importance to child health (indicated by weight and height for age) of economic development level [gross domestic product (GDP) converted to international dollars using purchasing power parity (PPP) rates: GDP-PPP], household wealth and maternal education and examines the modifying influence of national contexts on these estimates. It uses information collected from mothers aged 15-49-years participating in Demographic Health Surveys (DHS) conducted in 42 developing countries. In multilevel regression models, the three study variables exhibited strong independent associations with child health: GDP-PPP accounted for the largest amount of unique variation, followed by maternal education and household wealth. There was also substantial overlap (shared variance) between maternal education and the other two study variables. The regressions of child health on household wealth and maternal education exhibited substantial cross-national variation in both strength and form of association. Although higher education levels were associated with disproportionately greater returns to child health, the pattern for household wealth was erratic: in many countries there were diminishing returns to child health at higher levels of household wealth. We conclude that there are inextricable links among different strategies for improving child health and that policy planners, associating benefits with these strategies, must take into account the strong moderating impact of national context.

Geographical variation in echolocation call and body size of the Okinawan least horseshoe bat, Rhinolophus pumilus (Mammalia: Rhinolophidae), on Okinawa-jima Island, Ryukyu Archipelago, Japan.

Science.gov (United States)

Yoshino, Hajime; Matsumura, Sumiko; Kinjo, Kazumitsu; Tamura, Hisao; Ota, Hidetoshi; Izawa, Masako

2006-08-01

The Okinawan least horseshoe bat, Rhinolophus pumilus, is a cave-dwelling species endemic to the central and southern Ryukyus, Japan. We analyzed variation in the constant frequency (CF) of the echolocation call and in forearm length (FAL) of this species on Okinawa-jima Island on the basis of data for 479 individuals from 11 caves scattered over the island. CF values in samples from six caves, all located in the southwestern half of Okinawa-jima, were significantly higher than those in samples from five caves in the northeastern half of the island. Also, FAL was significantly greater in the latter group than in the former group, although the ranges of variation in this character substantially overlapped between the two groups. These results suggest substantial differentiation between R. pumilus populations on Okinawa-jima. The implications of our findings for the conservation of this endangered bat species are briefly discussed.

Low-level radioactive waste disposal technology development through a public process

International Nuclear Information System (INIS)

Murphy, M.P.; Hysong, R.J.; Edwards, C.W.

1989-01-01

When Pennsylvania's legislature ratified the Appalachian States Low-Level Radioactive Waste Compact in 1985, the Commonwealth of Pennsylvania became the host state designee for the compact's low-level radioactive waste (LLWR) disposal facility. Programs necessary for the establishment of this facility became the responsibility of the Department of Environmental Resources' (DER), Bureau of Radiation Protection's, Division of Nuclear Safety (DNS). It was realized early in the process that the technical aspects of this program, while challenging, probably were not the largest obstacle to completing the facility on schedule. The largest obstacle was likely to be public acceptance. Recognizing this, the DNS set out to develop a program that would maximize public involvement in all aspects of site and facility development. To facilitate public involvement in the process, the DNS established a LLRW advisory committee and a strategy for holding public meetings throughout Pennsylvania. As a result of the significant public involvement generated by these efforts, Pennsylvania passed, in February of 1988, one of the most stringent and technically demanding LLRW disposal laws in the nation. Hopefully, increased public confidence will reduce to a minimum public opposition to the facility

Global fishery development patterns are driven by profit but not trophic level.

Science.gov (United States)

Sethi, Suresh A; Branch, Trevor A; Watson, Reg

2010-07-06

Successful ocean management needs to consider not only fishing impacts but drivers of harvest. Consolidating post-1950 global catch and economic data, we assess which attributes of fisheries are good indicators for fishery development. Surprisingly, year of development and economic value are not correlated with fishery trophic levels. Instead, patterns emerge of profit-driven fishing for attributes related to costs and revenues. Post-1950 fisheries initially developed on shallow ranging species with large catch, high price, and big body size, and then expanded to less desirable species. Revenues expected from developed fisheries declined 95% from 1951 to 1999, and few high catch or valuable fishing opportunities remain. These results highlight the importance of economic attributes of species as leading indicators for harvest-related impacts in ocean ecosystems.

Three-level approach to quality programs for research, development and production

International Nuclear Information System (INIS)

Davis, A.H.; Bussolini, P.L.; Geoffrion, R.R.

1986-01-01

A primary mission of the Los Alamos National Laboratory is to develop nuclear weapons systems for the Department of Defense. The activities included in this effort cover a broad spectrum, ranging from pure research to routine production. In order to provide a workable framework for a comprehensive quality assurance program for these varied activities, we have proposed a three-level structure of quality plans, corresponding to a rough classification of the weapons work into three general categories. These categories are: (1) research into materials and processes, and preliminary development; (2) design, development, and fabrication of prototype components; (3) routine production, analysis, or refinement activities. The first category requires a quality program to assure the validity, reliability, and retrievability of the information developed; this is accomplished by a conscientious application of what is generally recognized as good laboratory practice. The second category requires in addition a strong emphasis on design review and inspection. For the third category, a comprehensive quality program is appropriate

DEVELOPMENT INSTITUTIONS AS AN EFFECTIVE MODEL AT THE REGIONAL LEVEL (ON THE EXAMPLE REPUBLIC OF TATARSTAN

Directory of Open Access Journals (Sweden)

Leysan Kashapova

2017-06-01

Full Text Available In the article questions of a choice of flexible instruments of government support to territories ensure their economic stability and economic growth. The formation of institutions is one of such approaches of profiling and of the results of operations which depends on the degree of development of territories. You have made the necessary relationship of selection and formation of development institutions from the strategic development priorities of the region We proved that effective implementation and activities of development institutions depends on the achievement of strategic targets set at the regional level and the municipal level.

Short-term visual memory properties sheet secondary school age with different levels of physical development

Directory of Open Access Journals (Sweden)

E.E. Menshikh

2013-12-01

Full Text Available Purpose . The results presented properties of short-term visual memory with different levels of physical development. Materials and methods. The study included 405 boys and girls Cherkassy school 11 in age from 13 to 16 years. Study of short-term visual memory was carried out using tables with 10 characters ( numbers and ambiguous geometric shapes . Indicator memory was the higher, the more information was displayed. Measured the length and body weight was recorded cardiorespiratory indicators - heart rate at rest and after 20 squats, lung capacity, breath-hold inspiration and expiration. Physical development factor was calculated by taking into account actual and average population indices. Results . Found that the volume of short-term visual memory, the boys and girls high school age does not depend on the level of their physical development. Despite the fact that the trend towards higher performance memory in groups of persons with a high level of physical development compared to their same age with medium and low levels, significant differences between the mean values for the most part have been identified. No significant differences between the values of the investigated cognitive function in groups by sex. Conclusions . Growth pattern memory with age in this period of ontogenesis preserved that coincides with the data presented in the scientific works of scientists.

Development of a microlesson in teaching energy levels of atoms

Science.gov (United States)

Rodriguez, Cherilyn A.; Buan, Amelia T.

2018-01-01

Energy levels of atoms is one of the difficult topics in understanding atomic structure of matter. It appears tobe abstract, theoretical and needs visual representation and images. Hence, in this study a microlesson in teaching the high school chemistry concept on the energy levels of atoms is developed and validated. The researchers utilized backward curriculum design in planning the microlesson to meet the standards of the science K-12 curriculum. The planning process of the microlesson involved a) Identifying the learning competencies in K-12 science curriculum b) write learning objectives c) planning of assessment tools d) making a storyboard e) designing the microlesson and validate and revise the microlesson. The microlesson made use of varied resources in the internet from which the students accessed and collected information about energy levels of atoms. Working in groups, the students synthesized the information on how and why fireworks produce various colors of light through a post card. Findings of the study showed that there was an increase of achievement in learning the content and the students were highly motivated to learn chemistry. Furthermore, the students perceived that the microlesson helped them to understand the chemistry concept through the use of appropriate multimedia activities.

Level of Rural Development in Burdwan and Murshidabad Districts, West Bengal: A Comparative Study

Directory of Open Access Journals (Sweden)

Syfujjaman Tarafder

2016-06-01

Full Text Available The key purpose of this research is to examine the level of attainment of rural development in the two districts—Burdwan and Murshidabad. The reasons for selecting these two districts stems from the fact that majority of the population of these two districts dwell in rural areas. The concept of rural development is comprehensive. It includes economic development of rural people through the development of productive sectors and employment associated with rural infrastructural development as well human development. Therefore, rural development includes in its domain all the aspects of human development of the rural people. The present Central as well as State Governments have undertaken different policies and plans to bring about positive changes amidst the rural people. In most cases, however, the policies and plans fail to achieve the desired level of changes in the rural areas (Desai, 1991. Although in fewer isolated cases, some success has been achieved, but overall development remains to be reached. This research, based mainly on secondary data aims to investigate the scale of progress in the two districts —Burdwan and Murshidabad of West Bengal, India, in the areas embracing social correlates of rural poverty, basic infrastructure facilities, standard of living and quality of life. The data are analysed with the help of statistical and cartographical analysis.

Student perceptions of independent versus facilitated small group learning approaches to compressed medical anatomy education.

Science.gov (United States)

Whelan, Alexander; Leddy, John J; Mindra, Sean; Matthew Hughes, J D; El-Bialy, Safaa; Ramnanan, Christopher J

2016-01-01

The purpose of this study was to compare student perceptions regarding two, small group learning approaches to compressed (46.5 prosection-based laboratory hours), integrated anatomy education at the University of Ottawa medical program. In the facilitated active learning (FAL) approach, tutors engage students and are expected to enable and balance both active learning and progression through laboratory objectives. In contrast, the emphasized independent learning (EIL) approach stresses elements from the "flipped classroom" educational model: prelaboratory preparation, independent laboratory learning, and limited tutor involvement. Quantitative (Likert-style questions) and qualitative data (independent thematic analysis of open-ended commentary) from a survey of students who had completed the preclerkship curriculum identified strengths from the EIL (promoting student collaboration and communication) and FAL (successful progression through objectives) approaches. However, EIL led to student frustration related to a lack of direction and impaired completion of objectives, whereas active learning opportunities in FAL were highly variable and dependent on tutor teaching style. A "hidden curriculum" was also identified, where students (particularly EIL and clerkship students) commonly compared their compressed anatomy education or their anatomy learning environment with other approaches. Finally, while both groups highly regarded the efficiency of prosection-based learning and expressed value for cadaveric-based learning, student commentary noted that the lack of grade value dedicated to anatomy assessment limited student accountability. This study revealed critical insights into small group learning in compressed anatomy education, including the need to balance student active learning opportunities with appropriate direction and feedback (including assessment). © 2015 American Association of Anatomists.

A Review of the Appropriateness of Existing Micro- and Meso-level Models of Athlete Development within Equestrian Sport

NARCIS (Netherlands)

de Haan, D.M.

2017-01-01

The aim of this paper was to use a case study approach to review the appropriateness of existing micro- and meso-level models of athlete development within the sport specific context of equestrianism. At a micro-level the Long Term Athlete Development (LTAD) model was chosen. At a meso-level, the

Development of High-Level Safety Requirements for a Pyroprocessing Facility

Energy Technology Data Exchange (ETDEWEB)

Seo, Seok Jun; Jo, Woo Jin; You, Gil Sung; Choung, Won Myung; Lee, Ho Hee; Kim, Hyun Min; Jeon, Hong Rae; Ku, Jeong Hoe; Lee, Hyo Jik [KAERI, Daejeon (Korea, Republic of)

2016-05-15

Korea Atomic Energy Research Institute (KAERI) has been developing a pyroproceesing technology to reduce the waste volume and recycle some elements. The pyroprocessing includes several treatment processes which are related with not only radiological and physical but also chemical and electrochemical properties. Thus, it is of importance to establish safety design requirements considering all the aspects of those properties for a reliable pyroprocessing facility. In this study, high-level requirements are presented in terms of not only radiation protection, nuclear criticality, fire protection, and seismic safety but also confinement and chemical safety for the unique characteristics of a pyroprocessing facility. Several high-level safety design requirements such as radiation protection, nuclear criticality, fire protection, seismic, confinement, and chemical processing were presented for a pyroprocessing facility. The requirements must fulfill domestic and international safety technology standards for a nuclear facility. Furthermore, additional requirements should be considered for the unique electrochemical treatments in a pyroprocessing facility.

The development of a high level radioactive waste management strategy

International Nuclear Information System (INIS)

Beale, H.

1979-11-01

The management of high level radioactive waste, from the removal of spent fuel from reactors to final disposal of vitrified waste, involves a complex choice of operational variables which interact one with another. If the various operations are designed and developed in isolation it will almost certainly lead to suboptimal choice. Management of highly active waste should therefore be viewed as a complete system and analysed in such a way that account is taken of the interactions between the various operations. This system must have clearly defined and agreed objectives as well as criteria against which performance can be judged. A thorough analysis of the system will provide a framework within which the necessary research and development can be carried out in a co-ordinated fashion and lead to an optimised strategy for managing highly active wastes. (author)

Human Development Index and Efficiency level of Social Security Hospitals

Directory of Open Access Journals (Sweden)

H. Sepehrdost

2012-04-01

Full Text Available Introduction & Objective: Hospitals as one of the main institutions providing health care services play an important role in the health system and allocate a high percentage of health sector's budget to them. This study aimed to answer whether social security hospitals efficiency levels are the same for all provinces in Iran? And whether any relationship exists between the human development indexes (HDI of the provinces and technical efficiency levels of the hospitals?Materials & Methods: Data envelopment analysis model has been used to measure technical efficiency of 65 social security hospitals, including small hospitals (working with lower than one hundred active beds and large hospitals (working with over one hundred active beds during the years 2007 to 2009. Further, the relationship between human development index and technical efficiency of hospitals in the provinces has been analyzed.Results: Results show that the average technical efficiency of small and large hospitals working in low and medium HDI provinces (0.912 and 0.937 are more than the average technical efficiency of hospitals in higher HDI provinces (0.870 and 0.887.Conclusion: It is recommended that social security organization concentrated distribute its hospital services in provinces with lower HDI and higher density of population living under the coverage of organization’s insurance. This will eventually puts its positive effects on per capita income of people, as well as more equitable distribution of income. (Sci J Hamadan Univ Med Sci 2012;19(1:32-38

[Association of human chorionic gonadotropin level in embryo culture media with early embryo development].

Science.gov (United States)

Wang, Haiying; Zhang, Renli; Han, Dong; Liu, Caixia; Cai, Jiajie; Bi, Yanling; Wen, Anmin; Quan, Song

2014-06-01

To investigate the association of human chorionic gonadotropin (HCG) level on day 3 of embryo culture with embryo development. Spent culture media were collected from individually cultured embryos on day 3 of in vitro fertilization and embryo transfer (IVF-ET) cycles. HCG concentration in the culture media was measured using an ELISA kit and its association with embryo development was assessed. In the 163 samples of embryo culture media from 60 patients, HCG was positive in 153 sample (93.8%) with a mean level of 0.85 ± 0.43 mIU/ml. The concentration of hCG in the culture media increased gradually as the number of blastomeres increased (F=2.273, P=0.03), and decreased as the morphological grade of the embryo was lowered (F=3.900, P=0.02). ELISA is capable of detecting HCG levels in spent culture media of embryos on day 3 of in vitro culture. The concentration of HCG in spent culture media is positively correlated with the status of early embryo development and implantation rate and thus serves as a useful marker for embryo selection in IVF-ET procedure.

Mechanisms of migration development at the community level: Migrant networks and types of links

Directory of Open Access Journals (Sweden)

Mónica Serban

2014-11-01

Full Text Available The paper approaches the problem of the development mechanism of international migration at community level.Some empirical observations cumulated during several researches,at origin and destination area, regarding Romanian migration to Spain constitute the starting points. Appealing to the distinction introduced by Mark Granovetter in 1976 between weak and strongties, we find that, if initially migration develops almost exclusively based on social relations that could be assimilated to strong ties,there is a moment in the process of development when the departures on the base of weak ties, with important consequences on the migrant’s situation at destination, increase.The paper tries to clarify, preponderantly invoking theoretical arguments,in what measure the departures based on weak ties between migrant and non migrant are normal in the process of international migration development at community level. The study concludes that, because of cumulative effects, migration evolution to a phase when the departure is possible based on weak ties is explainable.Two mechanisms mainly contribute to this result: enhancement of incentives to migrate (because of quantitative and qualitative information increase; visibility of migration effects in the origin area;changes of relative deprivation at community level and migration costs and risk lowering, with the consequence of reduction of effective support that a non-migrant needs from one migrant in order to migrate.

Phase 2 Neoadjuvant Treatment Intensification Trials in Rectal Cancer

DEFF Research Database (Denmark)

Teo, Mark T W; McParland, Lucy; Appelt, Ane L

2018-01-01

PURPOSE: Multiple phase 2 trials of neoadjuvant treatment intensification in locally advanced rectal cancer have reported promising efficacy signals, but these have not translated into improved cancer outcomes in phase 3 trials. Improvements in phase 2 trial design are needed to reduce these fals...

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

NARCIS (Netherlands)

Kenna, Kevin P.; van Doormaal, Perry T. C.; Dekker, Annelot M.; Ticozzi, Nicola; Kenna, Brendan J.; Diekstra, Frank P.; van Rheenen, Wouter; van Eijk, Kristel R.; Jones, Ashley R.; Keagle, Pamela; Shatunov, Aleksey; Sproviero, William; Smith, Bradley N.; van Es, Michael A.; Topp, Simon D.; Kenna, Aoife; Miller, Jack W.; Fallini, Claudia; Tiloca, Cinzia; McLaughlin, Russell L.; Vance, Caroline; Troakes, Claire; Colombrita, Claudia; Mora, Gabriele; Calvo, Andrea; Verde, Federico; Al-Sarraj, Safa; King, Andrew; Calini, Daniela; de Belleroche, Jacqueline; Baas, Frank; van der Kooi, Anneke J.; de Visser, Marianne; ten Asbroek, Anneloor L. M. A.; Sapp, Peter C.; McKenna-Yasek, Diane; Polak, Meraida; Asress, Seneshaw; Muñoz-Blanco, José Luis; Strom, Tim M.; Meitinger, Thomas; Morrison, Karen E.; Lauria, Giuseppe; Williams, Kelly L.; Leigh, P. Nigel; Nicholson, Garth A.; Blair, Ian P.; Leblond, Claire S.; Dion, Patrick A.; Rouleau, Guy A.

2016-01-01

To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted whole-exome analyses of 1,022 index familial ALS (FALS) cases and 7,315 controls. In a new screening strategy, we performed gene-burden analyses trained with established ALS genes and identified a

DEVELOPING A STRATEGY CONCEPT ON MICRO LEVELS

Directory of Open Access Journals (Sweden)

S. P. Burlankov

2014-01-01

Full Text Available Relevance of the topic of the study is that the conflicting tendencies of economic development, the need to consider a variety of factors internal and external environment in a changing operating environment in the paramount problem of providing concept enterprises as concept distributed in time. Variety of factors that influence the activity of enterprises, the ambiguity estimates of their effect, often lack the possibility of their accounting and forecasting, the complication of the problem to identify the interdependence of external and internal parameters of management lead to serious negative consequences, and often to the destruction of production and the economic system. This raises the need to develop new approaches and management techniques the intra interaction, based on the use of tools of market relations and the transformation of the elements of the market at the enterprise level. Insufficiently complete theoretical study concept issues, lack of models, diagrams, algorithms for the formation mechanism of industrial relations on the principles of intra-enterprise, ensuring longevity economic enterprises by integrating and mobilizing intra-building, deter-mined the choice of the research topic. Strategy - an integrated model of action designed to achieve the objectives of the enterprise. Content of the strategy is a set of decision rules used to determine the main directions of activity. In the literature on strategic planning, there are two opposing views on the understanding of the strategy. In the first case the strategy - it is a concrete long-term plan to achieve a certain goal, and develop a strategy - it is the process of finding a purpose and making long-term plan. This approach is based on the fact that all the emerging changes are predictable, occur-ring in the environment of the processes are deterministic and amenable to complete control and management. At the same time, both within the organization and outside it there

Developing expert systems for hazardous and low-level radioactive waste management

International Nuclear Information System (INIS)

Ferrada, J.J.; Stark, L.; Rodgers, B.R.

1988-01-01

Information about management of hazardous and low level wastes has been deposited in data bases, text files, graphics files, and other types of computer programs. Integrating such diverse data so that they are easily and quickly retrievable represents a challenge for busy managers who require immediate answers to their problems. Expert programs have been developed using expert shells and artificial intelligence computer languages as the central environment to produce integration

U.S. Programs in the development of spent fuel and high-level waste disposal technology

International Nuclear Information System (INIS)

Rusche, B.C.

1987-01-01

U. S. Progess in the development of a national high-level radioactive waste disposal system is reported. The mutual benefits of international cooperation in developing the technology for radioactive management and disposal are also described. (Huang)

EU-level competence development projects in agri-food-environment: the involvement of sectoral social partners

NARCIS (Netherlands)

Mulder, M.

2006-01-01

Purpose - The European Commission and social partner organisations at EU level encourage the lifelong development of qualifications and competence. This is reflected in many policy reports and reviews. This paper seeks to show the involvement of social partner organisations at the level of EU-funded

The Modeling of the Processes of Assessment and Analysis of the Level of Socio-Ecological-Economic Development of a Region

Directory of Open Access Journals (Sweden)

Pilko Andriy D.

2017-06-01

Full Text Available There presented results of the research of existing scientific and methodological, and theoretical approaches to management of the socio-ecological-economic development of a region with subsequent definition of priorities of the regional policy taking into account the concepts of security and development. Based on the study of literature sources and the analysis of the available statistical base, the problem of assessing the level of social, economic, ecological development, the level of sustainable development and the degree of harmonization of sustainable development of territorial systems of a region is formulated, and a possible method of its solution is suggested. The direction and nature of the cause-effect relationships between social tension and the levels of economic, environmental, social development and the level of sustainable development of a region are determined. There proposed a scheme to build models for assessing the effectiveness of levers for managing social, economic and environmental processes at the level of territorial systems in a region, taking into account the level of social tension and indicators of the investment component of development.

Development of nuclear thermal hydraulic verification tests and evaluation technology - Development of the ultrasonic method for two-phase mixture level measurement in nuclear reactor

Energy Technology Data Exchange (ETDEWEB)

No, Hee Cheon; Kim, Sang Jae; Kim, Hyung Tae; Moon, Young Min [Korea Advanced Institute of Science and Technology, Taejon (Korea)

2000-04-01

An ultrasonic method is developed for the measurement of the two-phase mixture level in the reactor vessel or steam generator. The ultrasonic method is selected among the several non-nuclear two-phase mixture level measurement methods through two steps of selection procedure. A commercial ultrasonic level measurement method is modified for application into the high temperature, pressure, and other conditions. The calculation method of the ultrasonic velocity is modified to consider the medium as the homogeneous mixture of air and steam, and to be applied into the high temperature and pressure conditions. The cross-correlation technique is adopted as a detection method to reduced the effects of the attenuation and the diffused reflection caused by surface fluctuation. The waveguides are developed to reduce the loss of echo and to remove the effects of obstructs. The present experimental study shows that the developed ultrasonic method measures the two-phase mixture level more accurately than the conventional methods do. 21 refs., 60 figs., 13 tabs. (Author)

Bridging Theory and Practice: Developing Lower-Level Skills in L2 Reading

Science.gov (United States)

Kato, Shigeo

2012-01-01

Studies on L2 reading have provided extensive evidence for the significant contribution of lower-level processing skills in learning to read and the critical impact on the overall development of L2 reading of more accurate and fluent connections between three sub-lexical components: phonology, orthography and semantics. The broad consensus among…

Development of multigene expression signature maps at the protein level from digitized immunohistochemistry slides.

Directory of Open Access Journals (Sweden)

Gregory J Metzger

Full Text Available Molecular classification of diseases based on multigene expression signatures is increasingly used for diagnosis, prognosis, and prediction of response to therapy. Immunohistochemistry (IHC is an optimal method for validating expression signatures obtained using high-throughput genomics techniques since IHC allows a pathologist to examine gene expression at the protein level within the context of histologically interpretable tissue sections. Additionally, validated IHC assays may be readily implemented as clinical tests since IHC is performed on routinely processed clinical tissue samples. However, methods have not been available for automated n-gene expression profiling at the protein level using IHC data. We have developed methods to compute expression level maps (signature maps of multiple genes from IHC data digitized on a commercial whole slide imaging system. Areas of cancer for these expression level maps are defined by a pathologist on adjacent, co-registered H&E slides, allowing assessment of IHC statistics and heterogeneity within the diseased tissue. This novel way of representing multiple IHC assays as signature maps will allow the development of n-gene expression profiling databases in three dimensions throughout virtual whole organ reconstructions.

Hypertension Knowledge-Level Scale (HK-LS: A Study on Development, Validity and Reliability

Directory of Open Access Journals (Sweden)

Cemalettin Kalyoncu

2012-03-01

Full Text Available This study was conducted to develop a scale to measure knowledge about hypertension among Turkish adults. The Hypertension Knowledge-Level Scale (HK-LS was generated based on content, face, and construct validity, internal consistency, test re-test reliability, and discriminative validity procedures. The final scale had 22 items with six sub-dimensions. The scale was applied to 457 individuals aged ≥18 years, and 414 of them were re-evaluated for test-retest reliability. The six sub-dimensions encompassed 60.3% of the total variance. Cronbach alpha coefficients were 0.82 for the entire scale and 0.92, 0.59, 0.67, 0.77, 0.72, and 0.76 for the sub-dimensions of definition, medical treatment, drug compliance, lifestyle, diet, and complications, respectively. The scale ensured internal consistency in reliability and construct validity, as well as stability over time. Significant relationships were found between knowledge score and age, gender, educational level, and history of hypertension of the participants. No correlation was found between knowledge score and working at an income-generating job. The present scale, developed to measure the knowledge level of hypertension among Turkish adults, was found to be valid and reliable.

Hypertension Knowledge-Level Scale (HK-LS): a study on development, validity and reliability.

Science.gov (United States)

Erkoc, Sultan Baliz; Isikli, Burhanettin; Metintas, Selma; Kalyoncu, Cemalettin

2012-03-01

This study was conducted to develop a scale to measure knowledge about hypertension among Turkish adults. The Hypertension Knowledge-Level Scale (HK-LS) was generated based on content, face, and construct validity, internal consistency, test re-test reliability, and discriminative validity procedures. The final scale had 22 items with six sub-dimensions. The scale was applied to 457 individuals aged ≥ 18 years, and 414 of them were re-evaluated for test-retest reliability. The six sub-dimensions encompassed 60.3% of the total variance. Cronbach alpha coefficients were 0.82 for the entire scale and 0.92, 0.59, 0.67, 0.77, 0.72, and 0.76 for the sub-dimensions of definition, medical treatment, drug compliance, lifestyle, diet, and complications, respectively. The scale ensured internal consistency in reliability and construct validity, as well as stability over time. Significant relationships were found between knowledge score and age, gender, educational level, and history of hypertension of the participants. No correlation was found between knowledge score and working at an income-generating job. The present scale, developed to measure the knowledge level of hypertension among Turkish adults, was found to be valid and reliable.

Development of a multimedia radionuclide exposure model for low-level waste management

International Nuclear Information System (INIS)

Onishi, Y.; Whelan, G.; Skaggs, R.L.

1982-03-01

A method is being developed for assessing exposures of the air, water, and plants to low-level waste (LLW) as a part of an overall development effort of a LLW site evaluation methodology. The assessment methodology will predict LLW exposure levels in the environment by simulating dominant mechanisms of LLW migration and fate. The methodology consists of a series of physics-based models with proven histories of success; the models interact with each other to simulate LLW transport in the ecosystem. A scaled-down version of the methodology was developed first by combining the terrestrial ecological model, BIOTRAN; the overland transport model, ARM; the instream hydrodynamic model, DKWAV; and the instream sediment-contaminant transport model, TODAM (a one-dimensional version of SERATRA). The methodology was used to simulate the migration of 239 Pu from a shallow-land disposal site (known as Area C) located near the head of South Mortandad Canyon on the LANL site in New Mexico. The scenario assumed that 239 Pu would be deposited on the land surface through the natural processes of plant growth, LLW uptake, dryfall, and litter decomposition. Runoff events would then transport 239 Pu to and in the canyon. The model provided sets of simulated LLW levels in soil, water and terrestrial plants in the region surrounding the site under a specified land-use and a waste management option. Over a 100-yr simulation period, only an extremely small quantity (6 x 10 -9 times the original concentration) of buried 239 Pu was taken up by plants and deposited on the land surface. Only a small fraction (approximately 1%) of that contamination was further removed by soil erosion from the site and carried to the canyon, where it remained. Hence, the study reveals that the environment around Area C has integrity high enough to curtail LLW migration under recreational land use

Development of a computerized data base for low-level radioactive waste leaching data: Topical report

International Nuclear Information System (INIS)

Dougherty, D.R.; Colombo, P.

1986-09-01

This report documents the development of a computerized data base (db) of leaching data for solidified low-level radioactive waste (LLW) forms. Brookhaven National Lab performed this work under contract with the US Department of Energy's Low-Level Waste Management Program as part of an effort to develop an accelerated leach test(s) that can be used to predict leachabilities of LLW forms over long time periods, i.e., hundreds of years. The accelerated leach test(s) is (are) to be developed based on knowledge of leaching mechanisms and factors that affect leaching. Although developed specifically for the Accelerated Leach Test(s) Program, this db may be useful to others concerned with the management of low-level waste. The db is being developed to provide efficient data compilation and analysis capabilities. The data compiled in the db, which include data from the Accelerated Leach Test(s) Program and selected data from the literature, have been selected to elucidate leaching mechanisms and factors that affect leaching and are not meant to be a comprehensive compilation of leaching data. This report presents the data compilation aspect of the db. It does not present the programmatic results obtained from analysis of the data regarding leaching mechanisms and factors that affect leaching, which will be presented in reports from the Accelerated Leach Test(s) Program. 6 refs

Development of a radioimmunoassay for circulating levels of gonadotropin releasing hormone

International Nuclear Information System (INIS)

Moodbidri, S.B.; Joshi, L.R.; Sheth, A.R.; Rao, S.S.

1976-01-01

A specific and sensitive radioimmunoassay system has been developed for measuring gonadotropin releasing hormone (GnRH) in unextracted human serum. Circulating levels of GnRH, LH and FSH were determined in 37 serum samples obtained from twenty normal healthy women on different days of the menstrual cycle. GnRH and LH but not FSH exhibited similar patterns during the menstrual cycle. 125 I-labelled GnRH was used in the RIA system. (author)

Developing integrated performance assessment and forecasting the level of financial and economic enterprise stability

Directory of Open Access Journals (Sweden)

Khudyakova T.A.

2017-01-01

Full Text Available The article deals with the problem of assessing and forecasting the level of financial and economic enterprise stability through the integrated indicators development. Currently, many enterprises operate under variable external environment, which imposes a strict requirement to consider this uncertainty. For the evaluation, analysis and prediction of the sustainability of the enterprise in the conditions of crisis we believe it possible and necessary to use the apparatus of probability theory and mathematical statistics. This problem solution will improve quantitative assessing the financial and economic stability level, forecasting possible scenarios of the enterprise development and, therefore, based on the proactive management principles and adaptation processes will greatly increase their effective functioning, as well as reduce bankruptcy probability.

Selection of the best security controls for rapid development of enterprise-level cyber security

OpenAIRE

Tytarenko, Oleksandr

2017-01-01

Approved for public release; distribution is unlimited State-supported cyber attacks, cyber espionage campaigns, and hacktivist movements have forced many states to accelerate their cyber defense development in order to achieve at least a minimum level of protection against expanding threats of cyber space. As with any other development effort, cyber capability development requires resources of time, money, and people, which in most cases are very restricted. To rapidly build up the first ...

Incorporating regional growth into forecasts of greenhouse gas emissions from project-level residential and commercial development

International Nuclear Information System (INIS)

Rowangould, Dana; Eldridge, Melody; Niemeier, Deb

2013-01-01

To better understand the greenhouse gas (GHG) implications of land use planning decisions, regional planning organizations have developed tools to forecast the emissions from project-level residential and commercial development. This paper reviews the state of GHG emissions forecasting methods for project-level development. We argue that when forecasting changes in regional emissions it is important to make explicit what is assumed about a project′s effect on the population of residents and businesses in the region. We present five regional growth assumptions capturing the range of ways that project-level development might influence (i) construction and occupancy of similar developments elsewhere in a region and (ii) relocation of the initial activities that occur on-site before the project is built. We show that current forecasting tools inconsistently address the latter when they are interpreted as forecasted changes in regional emissions. Using a case study in Yolo County, California we demonstrate that forecasted changes in regional emissions are greatly affected by the regional growth assumption. In the absence of information about which regional growth assumption is accurate, we provide guidelines for selection of a conservative regional growth assumption. - Highlights: • Current tools inconsistently forecast GHG emissions from project-level development. • We outline five assumptions about how projects may affect regional growth. • Our assumptions capture a range of economic and population effects of projects. • Our case study shows that growth assumptions greatly affect regional GHG estimates. • We provide guidelines for selecting a conservative regional growth assumption

Investigation of the effect of hemoglobin F and A levels on development of retinopathy of prematurity.

Science.gov (United States)

Erdöl, Hidayet; Hacioglu, Dilek; Kola, Mehmet; Türk, Adem; Aslan, Yakup

2017-04-01

To investigate the effect of hemoglobin F (HbF) and hemoglobin A (HbA) levels on development of retinopathy of prematurity (ROP) in premature infants. In this prospective study, blood samples were collected from the side of the heel of 49 premature infants at postnatal months 0, 1, 2, and 3. HbF and HbA levels were measured in all samples and analyzed statistically. Furthermore, correlation analysis was performed regarding development of ROP, blood transfusion, and HbF and HbA levels. A total of 49 infants were included. The mean gestational age of the premature infants was 30.9 ± 2.7 weeks (range, 25-35 weeks); mean birth weight, 1542 ± 582 g (range, 520-3240 g). Of the 49 premature infants, stage 1 ROP or above developed in 26 (53%). Mean HbF levels were lower at postnatal months 1 and 2 in premature infants with ROP compared to those without ROP (P = 0.013 and 0.02, respectively); however, mean HbA levels were higher in the infants with ROP than the others (P = 0.034 and 0.029, respectively). Analysis of covariance that ignored transfusion revealed no difference between the means of Hb variants in the infants with and without ROP (P = 0.572 and 0.486). Blood transfusion significantly altered the levels of HbF and HbA in premature infants, and Hb variants have no direct effect on development of ROP. Copyright © 2017 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

Development of very low-level radioactive waste sequestration process criteria

Energy Technology Data Exchange (ETDEWEB)

Chan, N.; Wong, P., E-mail: nicholas.chan@cnl.ca [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada)

2015-12-15

Segregating radioactive waste at the source and reclassifying radioactive waste to lower waste classes are the key activities to reduce the environmental footprint and long-term liability. In the Canadian Standards Association's radioactive waste classification system, there are 2 sub-classes within low-level radioactive waste: very short-lived radioactive waste and very low-level radioactive waste (VLLW). VLLW has a low hazard potential but is above the Canadian unconditional clearance criteria as set out in Schedule 2 of Nuclear Substances and Devices Regulations. Long-term waste management facilities for VLLW do not require a high degree of containment and isolation. In general, a relatively low-cost near-surface facility with limited regulatory control is suitable for VLLW. At Canadian Nuclear Laboratories' Chalk River Laboratories site an initiative, VLLW Sequestration, was implemented in 2013 to set aside potential VLLW for temporary storage and to be later dispositioned in the planned VLLW facility. As of May 2015, a total of 236m{sup 3} resulting in approximately $1.1 million in total savings have been sequestered. One of the main hurdles in implementing VLLW Sequestration is the development of process criteria. Waste Acceptance Criteria (WAC) are used as a guide or as requirements for determining whether waste is accepted by the waste management facility. Establishment of the process criteria ensures that segregated waste materials have a high likelihood to meet the VLLW WAC and be accepted into the planned VLLW facility. This paper outlines the challenges and various factors which were considered in the development of interim process criteria. (author)

Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases

NARCIS (Netherlands)

van Rheenen, Wouter; van Blitterswijk, Marka; Huisman, Mark H. B.; Vlam, Lotte; van Doormaal, Perry T. C.; Seelen, Meinie; Medic, Jelena; Dooijes, Dennis; de Visser, Marianne; van der Kooi, Anneke J.; Raaphorst, Joost; Schelhaas, Helenius J.; van der Pol, W. Ludo; Veldink, Jan H.; van den Berg, Leonard H.

2012-01-01

Objective: To assess the frequency and phenotype of hexanucleotide repeat expansions in C9ORF72 in a large cohort of patients of Dutch descent with familial (fALS) and sporadic (sALS) amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), and primary lateral sclerosis (PLS).

Cloud Computing: The Level of Awareness Amongst Small & Medium-sized Enterprises (SMEs) in Developing Economies

DEFF Research Database (Denmark)

Yeboah-Boateng, Ezer Osei; Essandoh, Kofi Asare

2013-01-01

Cloud computing services are being touted as a major enabler for small businesses lately. This new paradigm is seen to offer unique opportunities to small and medium enterprises (SMEs) worldwide and developing economies are no exception. It presents SMEs access to similar technologies available...... indicated that a slight majority of the respondents were familiar with cloud computing on the individual level but the level of awareness amongst the larger SME industry was low to medium. The finding therefore recommends education and sensitization on cloud computing in order to increase awareness...... to their larger counterparts and those in the developed world which inherently creates innovativeness, increases competitive advantage and impacts their operations and processes. This paper seeks to determine the level of awareness and familiarity with this emerging computing paradigm. The results of the study...

Development of psychopathology in deployed armed forces in relation to plasma GABA levels.

Science.gov (United States)

Schür, Remmelt R; Boks, Marco P; Geuze, Elbert; Prinsen, Hubertus C; Verhoeven-Duif, Nanda M; Joëls, Marian; Kahn, René S; Vermetten, Eric; Vinkers, Christiaan H

2016-11-01

The GABA system is pivotal for an adequate response to a stressful environment but has remained largely unexplored in this context. The present study investigated the relationship of prospectively measured plasma GABA levels with psychopathology symptoms in military deployed to Afghanistan at risk for developing psychopathology following trauma exposure during deployment, including posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Plasma GABA levels were measured in military personnel (N=731) one month prior to deployment (T0), and one (T1) and six months (T2) after deployment using ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). Mental health problems and depressive symptoms were measured with the Dutch revised Symptom Checklist (SCL-90) and PTSD symptoms with the Dutch Self-Rating Inventory for PTSD (SRIP). Six months after deployment increases in GABA concentrations were present in individuals who had developed mental health problems (T2: β=0.06, p=1.6×10 -2 , T1: β=4.7×10 -2 , p=0.13), depressive symptoms (T2: β=0.29, p=7.9×10 -3 , T1: β=0.23, p=0.072) and PTSD symptoms at T2 (T2: β=0.12, p=4.3×10 -2 , T1: β=0.11, p=0.13). Plasma GABA levels prior to and one month after deployment poorly predicted a high level of psychopathology symptoms either one or six months after deployment. The number of previous deployments, trauma experienced during deployment, childhood trauma, age and sex were not significantly associated with plasma GABA levels over time. Exclusion of subjects who either started or stopped smoking, alcohol or medication use between the three time points rendered the association of increasing GABA levels with the emergence of psychopathology symptoms more pronounced (mental health problems at T2: β=0.09, p=4.2×10 -3 ; depressive symptoms at T2: β=0.35, p=3.5×10 -3 , PTSD symptoms at T2: β=0.17, p=1.7×10 -2 ). To our knowledge, this is the first study to provide

Development of safeguards information treatment system at the facility level

Energy Technology Data Exchange (ETDEWEB)

Lee, Byung Doo; Song, Dae Yong; So, Dong Sup; Kwack, Eun Ho [Korea Atomic Energy Research Institute, Taejeon (Korea)

2000-04-01

Safeguards Information Treatment System(SITS) at the facility level is required to implement efficiently the obligations under the Korea-IAEA Safeguards Agreement, bilateral agreements with other countries and domestic law. In this report, the requirements and major functions of SITS were considered, and the error checking methods and the relationships of safeguards information were reviewed. SITS will be developed to cover the different accounting procedures and methods applied at the various facilities under IAEA safeguards. Also, the resolved result of the Y2K problem in the existing nuclear material accounting program was described. 3 tabs. (Author)

Novel heterozygous nonsense mutation of the OPTN gene segregating in a Danish family with ALS

DEFF Research Database (Denmark)

Tümer, Zeynep; Bertelsen, Birgitte; Gredal, Ole

2012-01-01

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. About 10% of ALS cases are familial (FALS) and the genetic defect is known only in approximately 20%-30% of these cases. The most common genetic cause of ALS is SOD1 (superoxide dismutase 1) mutation. Very recently......, mutations of the optineurin gene (OPTN), which is involved in open-angle glaucoma, were identified in 3 Japanese patients/families with ALS, and subsequently in a few FALS patients of European descent. We found a heterozygous nonsense mutation (c.493C>T, p.Gln165X, exon 6) in the OPTN gene in a Danish...... patient with ALS, and the mutation segregated from his affected father. The p.Gln165X mutation could not be detected in 1070 healthy Danish controls, in 1000 Danish individuals with metabolic phenotypes or in 64 sporadic ALS (SALS) cases. The p.Gln165X mutation described in this study is the first...

The course of the professional development and the level of job satisfaction among physiotherapists

Directory of Open Access Journals (Sweden)

Agata A. Jaros

2015-03-01

Full Text Available Introduction: The occupation of a physiotherapist, due to its nature, is very challenging. It requires continuous work on oneself and the improvement of professional skills. Aim of the research : To assess the level of competence, professional development, and job satisfaction among a group of active physiotherapists. Material and methods : The study involved a group of 62 physiotherapists, among whom a questionnaire was conducted. The survey contained questions concerning demographic data of the respondents, general working conditions, and satisfaction with their profession. The calculations and graphs presented in the descriptive statistics, as well as the statistical hypotheses, were all performed in MS Excel’s spread sheet and T-Czuprow’s similarity rate. Results: The results show the high activity concerning participation in specialised courses in physiotherapy methods and the use of specialised literature. The level of job satisfaction is high, at about 70%, in all groups. The character of the work and positive relations with co-workers and supervisors were assessed highest and salary and promotion opportunities lowest from all the determinants of job satisfaction. Although the level of job satisfaction itself is acceptable, nearly 1/3 of respondents have no plans for further development and 40% do not plan to follow this profession in the future. Conclusions : After graduation they often willingly improve their professional qualifications. The level of job satisfaction itself is acceptable; however, the lack of plans for further development or willingness to follow this profession in the future can cause a significant decline in the number of professionally active physiotherapists.

Development of a package program for estimating ground level concentrations of radioactive gases

International Nuclear Information System (INIS)

Nilkamhang, W.

1986-01-01

A package program for estimating ground level concentration of radioactive gas from elevate release was develop for use on IBM P C microcomputer. The main program, GAMMA PLUME NT10, is based on the well known VALLEY MODEL which is a Fortran computer code intended for mainframe computers. Other two options were added, namely, calculation of radioactive gas ground level concentration in Ci/m 3 and dose equivalent rate in mren/hr. In addition, a menu program and editor program were developed to render the program easier to use since the option could be readily selected and the input data could be easily modified as required through the keyboard. The accuracy and reliability of the program is almost identical to the mainframe. Ground level concentration of radioactive radon gas due to ore program processing in the nuclear chemistry laboratory of the Department of Nuclear Technology was estimated. In processing radioactive ore at a rate of 2 kg/day, about 35 p Ci/s of radioactive gas was released from a 14 m stack. When meteorological data of Don Muang (average for 5 years 1978-1982) were used maximum ground level concentration and the dose equivalent rate were found to be 0.00094 p Ci/m 3 and 5.0 x 10 -10 mrem/hr respectively. The processing time required for the above problem was about 7 minutes for any case of source on IBM P C which was acceptable for a computer of this class

Comparison of real development levels of countries: Genesis and perspectives

Directory of Open Access Journals (Sweden)

Prekajac Zora

2007-01-01

Full Text Available Comparison of levels of development among countries is usually done by reducing values in national currencies with a common denominator, using the official exchange rate. Because of its unreality, the values calculated in this way do not illustrate real relations between compared countries. That brings about the launching of the UN International Comparison Project (latter Programme with two fold aims: developing a method for international comparison of real domestic product which could be applied to a number of very heterogeneous countries, and the comparison of growing number of very different countries. Until now six phases of comparisons are finished. Taking into consideration problems that appeared in the realization of the VI ICP phase as well as quality improvement proposals, a decision has been made to launch a new, global round for 2003-2006. Comparison will cover 150 countries (the widest coverage ever. This will give global character to the comparison, which was the end cause of the ICP.

A process for developing and revising a learning progression on sea level rise using learners' explanations

Science.gov (United States)

McDonald, Robert Christopher

The purpose of this study was to explore the process of developing a learning progression (LP) on constructing explanations about sea level rise. I used a learning progressions theoretical framework informed by the situated cognition learning theory. During this exploration, I explicitly described my decision-making process as I developed and revised a hypothetical learning progression. Correspondingly, my research question was: What is a process by which a hypothetical learning progression on sea level rise is developed into an empirical learning progression using learners' explanations? To answer this question, I used a qualitative descriptive single case study with multiple embedded cases (Yin, 2014) that employed analytic induction (Denzin, 1970) to analyze data collected on middle school learners (grades 6-8). Data sources included written artifacts, classroom observations, and semi-structured interviews. Additionally, I kept a researcher journal to track my thinking about the learning progression throughout the research study. Using analytic induction to analyze collected data, I developed eight analytic concepts: participant explanation structures varied widely, global warming and ice melt cause sea level rise, participants held alternative conceptions about sea level rise, participants learned about thermal expansion as a fundamental aspect of sea level rise, participants learned to incorporate authentic scientific data, participants' mental models of the ocean varied widely, sea ice melt contributes to sea level rise, and participants held vague and alternative conceptions about how pollution impacts the ocean. I started with a hypothetical learning progression, gathered empirical data via various sources (especially semi-structured interviews), revised the hypothetical learning progression in response to those data, and ended with an empirical learning progression comprising six levels of learner thinking. As a result of developing an empirically based LP

Exposure to environmentally-relevant levels of ozone negatively influence pollen and fruit development

International Nuclear Information System (INIS)

Gillespie, Colin; Stabler, Daniel; Tallentire, Eva; Goumenaki, Eleni; Barnes, Jeremy

2015-01-01

A combination of in vitro and in vivo studies on tomato (Lycopersicon esculentum Mill. cv. Triton) revealed that environmentally-relevant levels of ozone (O_3) pollution adversely affected pollen germination, germ tube growth and pollen-stigma interactions – pollen originating from plants raised in charcoal-Purafil"® filtered air (CFA) exhibited reduced germ tube development on the stigma of plants exposed to environmentally-relevant levels of O_3. The O_3-induced decline in in vivo pollen viability was reflected in increased numbers of non-fertilized and fertilized non-viable ovules in immature fruit. Negative effects of O_3 on fertilization occurred regardless of the timing of exposure, with reductions in ovule viability evident in O_3 × CFA and CFA × O_3 crossed plants. This suggests O_3-induced reductions in fertilization were associated with reduced pollen viability and/or ovule development. Fruit born on trusses independently exposed to 100 nmol mol"−"1 O_3 (10 h d"−"1) from flowering exhibited a decline in seed number and this was reflected in a marked decline in the weight and size of individual fruit – a clear demonstration of the direct consequence of the effects of the pollutant on reproductive processes. Ozone exposure also resulted in shifts in the starch and ascorbic acid (Vitamin C) content of fruit that were consistent with accelerated ripening. The findings of this study draw attention to the need for greater consideration of, and possibly the adoption of weightings for the direct impacts of O_3, and potentially other gaseous pollutants, on reproductive biology during ‘risk assessment’ exercises. - Highlights: • Environmentally-relevant levels of ozone exert negative effects on pollen viability that translate into direct impacts on fruit yield. • Negative impacts of O_3 pollution on reproductive processes were evident regardless of the stage of plant development. • Exposure to environmentally-relevant levels of O_3

The Changes of the Human Development on Micro-Regional and Settlement Levels

Directory of Open Access Journals (Sweden)

Katalin Lipták

2015-10-01

Full Text Available The purpose of this paper is to define and estimate the human potential of the settlements in South-Cserehát,, Hungary. The human development index in the classical view can be estimated atmicroregional level with only hard distortions, to which the list of starting indicators differ from the usual indicators, such as GDP and GNI, the life expectancy at birth and the portion of taking part in education. However, the estimating calculations made for defining the human potential in a settlement level should be handled with hard restrictions , at the same time it perfectly shows the formation of the human factor in the region. As a research question the following was defined: In what range has the human potential changed on the basis of the census data and what kind of configuration changes have happened in the South-Cserehát? The aim of the study to attempt to estimate the HDI on settlement level.

Astatine-211 Radiochemistry: The Development Of Methodologies For High Activity Level Radiosynthesis

International Nuclear Information System (INIS)

Zalutsky, Michael R.

2012-01-01

Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for α-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the α-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At-labeled targeted

ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

Energy Technology Data Exchange (ETDEWEB)

MICHAEL R. ZALUTSKY

2012-08-08

Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

How community-level social and economic developments have changed the patterns of substance use in a transition economy?

Science.gov (United States)

Yang, Xiaozhao Y

2017-07-01

Most social changes take place at the community level before indirectly affecting individuals. Although the contextual effect is far-reaching, few studies have investigated the important questions of: how do community-level developments affect drinking and smoking, and how do they change the existing gender and income patterns of drinking and smoking, particularly in transition economies? In this study, I used a Chinese panel dataset between 1991 and 2011 to reveal the moderating effects of community developments. Through multilevel growth curve modeling that controls for age, period, and cohort effects, as well as individual- and community-level covariates, I found that community-level economic development and social development are negatively associated with drinking and smoking. Moreover, economic and social developments also moderate the important influences of income and gender: women start to drink more in communities with higher economic development; the traditionally positive association between income and smoking/drinking is also reversed, i.e. the rich start to smoke and drink less in communities with higher social development. This study concludes that the rapid changes in communal social and economic structures have created new health disparities based on the gender and socioeconomic hierarchy. Copyright © 2017 Elsevier Ltd. All rights reserved.

Preliminary Consideration for the Development of Regulatory Level 2 PSA Model

International Nuclear Information System (INIS)

Lee, Chang-Ju

2006-01-01

In order to assess the validity of PSA (probabilistic safety assessment) results and to establish regulatory requirements for relevant safety issues most of the regulators want to develop an independent and convenient risk assessment model including Level 2 PSA area. As this model and framework should be implicitly independent on the licensee's PSA model, it has a primary objective directly for applying to the risk-informed regulatory affairs and for supporting those kinds of works. According this, the regulator can take an objective view for the uncertainty of risk information made by the licensee and keep up the capability and decision-making framework for overall risk assessment results. In addition, the regulatory model may be used to verify and validate the operational risk levels of all engineered safety features of nuclear power plants (NPPs). An issue for plant-specific application of safety goals was previously identified in the US NRC's risk-informed regulatory guidance development activities, and discussed in many Commission papers, e. g. SECY-97-287, which identifies the goal for large early release frequency (LERF). LERF defines a containment performance criteria derived from the quantitative health objectives. As we know, the LERF was chosen to assess risk significance in Regulatory Guide 1.174 (2002) again, which provides one measure of the performance of the containment barrier, and represents a surrogate for early health effects

Development of a new glove for glove boxes with high level performances

International Nuclear Information System (INIS)

Jerome Blancher; Jean-Marc Poirier

2006-01-01

This paper describes the results of a joint technological program of COGEMA and MAPA to develop a new generation of glove for glove boxes. The mechanical strength of this glove is twice as high as the best characteristics of gloves available on the market. This new generation of product has both a higher level of performance and better ergonomics. (authors)

Development of a new glove for glove boxes with high level performances

Energy Technology Data Exchange (ETDEWEB)

Jerome Blancher [AREVA/COGEMA Recycling Business Unit, BP 94176 - 30204 Bagnols-sur-Ceze Cedex (France); Jean-Marc Poirier [MAPA SPONTEX, BP 190 - 92205 Neuilly sur Seine Cedex (France)

2006-07-01

This paper describes the results of a joint technological program of COGEMA and MAPA to develop a new generation of glove for glove boxes. The mechanical strength of this glove is twice as high as the best characteristics of gloves available on the market. This new generation of product has both a higher level of performance and better ergonomics. (authors)

Preliminary development of POEAW in enhancing K-11 students’ understanding level on impulse and momentum

Science.gov (United States)

Luthfiani, T. A.; Sinaga, P.; Samsudin, A.

2018-05-01

We have been analyzed that there were limited research about Predict-Observe- Explain which use writing process with conceptual change text strategy. This study aims to develop a learning model namely Predict-Observe-Explain-Apply-Writing (POEAW) which is able to enhance students’ understanding level. The research method utilized the 4D model (Defining, Designing, Developing and Disseminating) that is formally limited to Developing Stage. There are four experts who judge the learning component (syntax, lesson plan, teaching material and student worksheet) and matter component (learning quality and content component). The result of this study are obtained expert validity test score average of 87% for learning content and 89% for matter component that means the POEAW is valid and can be tested in classroom learning. This research producing POEAW learning model that has five main steps, Predict, Observe, Explain, Apply and Write. To sum up, we have early developed POEAW in enhancing K-11 students’ understanding levels on impulse and momentum.

MANAGEMENT OF THE PROCESS OF DEVELOPMENT OF PRODUCTS: STUDY OF THE LEVELS OF MATURITY IN FOOD INDUSTRIES

Directory of Open Access Journals (Sweden)

De Greef, Melisa

2017-12-01

Full Text Available The development of new products is an essential activity for the survival and competitiveness of companies. This process involves different stages, from the identification of consumers needs to the launch, follow-up and recall of the product in the market. At food producing industries, Product Development Process Management has an important role, due to the competitive environment in which they operate. However, in these companies’ different levels of the process systematization are perceived. In this sense, Maturity Level provides guidelines to observe which best practices are institutionalized and become effective in the organization. Selected literature recognizes five maturity levels: Basic, Intermediate, Measurable, Controlled and Continuous Improvement. This paper presents a diagnosis of the maturity level of Product Development Process Management on food companies Santa Fe (Argentina. Eleven companies belonging to three sectors of economic activity, selected according to their importance for the region (dairy products, inputs and meat are selected. A descriptive study is carried out through the application of a semi-structured questionnaire. Among the main conclusions, it is observed that companies interviewed have Basic and Intermediate Maturity Levels. Particularly, there are remarkable differences in relation to the company size (to a larger size, larger degree of PDP process systematization and higher maturity level.

Development of a non-contextual model for determining the autonomy level of intelligent unmanned systems

Science.gov (United States)

Durst, Phillip J.; Gray, Wendell; Trentini, Michael

2013-05-01

A simple, quantitative measure for encapsulating the autonomous capabilities of unmanned systems (UMS) has yet to be established. Current models for measuring a UMS's autonomy level require extensive, operational level testing, and provide a means for assessing the autonomy level for a specific mission/task and operational environment. A more elegant technique for quantifying autonomy using component level testing of the robot platform alone, outside of mission and environment contexts, is desirable. Using a high level framework for UMS architectures, such a model for determining a level of autonomy has been developed. The model uses a combination of developmental and component level testing for each aspect of the UMS architecture to define a non-contextual autonomous potential (NCAP). The NCAP provides an autonomy level, ranging from fully non- autonomous to fully autonomous, in the form of a single numeric parameter describing the UMS's performance capabilities when operating at that level of autonomy.

Development of depression in survivors of childhood and adolescent cancer: a multi-level life course conceptual framework.

Science.gov (United States)

Kaye, Erica C; Brinkman, Tara M; Baker, Justin N

2017-06-01

As therapeutic and supportive care interventions become increasingly effective, growing numbers of childhood and adolescent cancer survivors face a myriad of physical and psychological sequelae secondary to their disease and treatment. Mental health issues, in particular, present a significant problem in this unique patient population, with depression affecting a sizable number of childhood and adolescent cancer survivors. Multiple key determinants impact a survivor's risk of developing depression, with variables traversing across biologic, individual, family, community, and global levels, as well as spanning throughout the life course of human development from the preconception and prenatal periods to adulthood. A multi-level life course conceptual model offers a valuable framework to identify and organize the diverse variables that modulate the risk of developing depression in survivors of childhood and adolescent cancer. This review describes the first multi-level life course perspective applied to development of depression in childhood and adolescent cancer survivors. This conceptual framework may be used to guide the investigation of mental health interventions for SCACs to ensure that key determinants of depression occurrence are adequately addressed across various levels and throughout the life trajectory.

Between Product Development and Mass Production: Tensions as Triggers for Concept-Level Learning

Science.gov (United States)

Jalonen, Meri; Ristimäki, Päivi; Toiviainen, Hanna; Pulkkis, Anneli; Lohtander, Mika

2016-01-01

Purpose: This paper aims to analyze learning in organizational transformations by focusing on concept-level tensions faced in two young companies, which were searching for a reorientation of activity with a production network between innovative product development and efficient mass production. Design/methodology/approach: An intervention-based…

PERFORMANCE AND DEVELOPMENT LEVEL - COMPARATIVE ANALYSIS OF DISPARITIES AMONG REGIONS OF DEVELOPMENT AND MACRO-REGIONS IN ROMANIA

Directory of Open Access Journals (Sweden)

MARIA OŢIL

2015-03-01

Full Text Available The major challenge of the regional policies is to mitigate the social and economic disparities between different territories and regions. The immediate reality shows that this is a problem which is neither simple nor for short term. For Romania, which has large lags behind compared to the economically developed countries, the intense mobilization of internal and external factors of economic growth in order to reduce and eliminate disparities compared to other countries, is a definite necessity, a regularity resulting from regional and national interests in terms of its finality - the welfare of society. The economic crisis has increased regional disparities in the European Union countries, these especially affecting the countries which are less economically efficient. The present research aims at accomplishing a comparative analysis regarding disparities among regions of development and macro-regions of Romania in order to assess the performance of the productive sector, of the structural types of economies and of their level of development.

Sex Differences in Brain Thyroid Hormone Levels during Early Post-Hatching Development in Zebra Finch (Taeniopygia guttata.

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Shinji Yamaguchi

Full Text Available Thyroid hormones are closely linked to the hatching process in precocial birds. Previously, we showed that thyroid hormones in brain had a strong impact on filial imprinting, an early learning behavior in newly hatched chicks; brain 3,5,3'-triiodothyronine (T3 peaks around hatching and imprinting training induces additional T3 release, thus, extending the sensitive period for imprinting and enabling subsequent other learning. On the other hand, blood thyroid hormone levels have been reported to increase gradually after hatching in altricial species, but it remains unknown how the brain thyroid hormone levels change during post-hatching development of altricial birds. Here, we determined the changes in serum and brain thyroid hormone levels of a passerine songbird species, the zebra finch using radioimmunoassay. In the serum, we found a gradual increase in thyroid hormone levels during post-hatching development, as well as differences between male and female finches. In the brain, there was clear surge in the hormone levels during development in males and females coinciding with the time of fledging, but the onset of the surge of thyroxine (T4 in males preceded that of females, whereas the onset of the surge of T3 in males succeeded that of females. These findings provide a basis for understanding the functions of thyroid hormones during early development and learning in altricial birds.

Sex Differences in Brain Thyroid Hormone Levels during Early Post-Hatching Development in Zebra Finch (Taeniopygia guttata).

Science.gov (United States)

Yamaguchi, Shinji; Hayase, Shin; Aoki, Naoya; Takehara, Akihiko; Ishigohoka, Jun; Matsushima, Toshiya; Wada, Kazuhiro; Homma, Koichi J

2017-01-01

Thyroid hormones are closely linked to the hatching process in precocial birds. Previously, we showed that thyroid hormones in brain had a strong impact on filial imprinting, an early learning behavior in newly hatched chicks; brain 3,5,3'-triiodothyronine (T3) peaks around hatching and imprinting training induces additional T3 release, thus, extending the sensitive period for imprinting and enabling subsequent other learning. On the other hand, blood thyroid hormone levels have been reported to increase gradually after hatching in altricial species, but it remains unknown how the brain thyroid hormone levels change during post-hatching development of altricial birds. Here, we determined the changes in serum and brain thyroid hormone levels of a passerine songbird species, the zebra finch using radioimmunoassay. In the serum, we found a gradual increase in thyroid hormone levels during post-hatching development, as well as differences between male and female finches. In the brain, there was clear surge in the hormone levels during development in males and females coinciding with the time of fledging, but the onset of the surge of thyroxine (T4) in males preceded that of females, whereas the onset of the surge of T3 in males succeeded that of females. These findings provide a basis for understanding the functions of thyroid hormones during early development and learning in altricial birds.

Development of prolonged standing strain index to quantify risk levels of standing jobs.

Science.gov (United States)

Halim, Isa; Omar, Abdul Rahman

2012-01-01

Many occupations in industry such as metal stamping workers, electronics parts assembly operators, automotive industry welders, and lathe operators require working in a standing posture for a long time. Prolonged standing can contribute to discomfort and muscle fatigue particularly in the back and legs. This study developed the prolonged standing strain index (PSSI) to quantify the risk levels caused by standing jobs, and proposed recommendations to minimize the risk levels. Risk factors associated with standing jobs, such as working posture, muscles activity, standing duration, holding time, whole-body vibration, and indoor air quality, were the basis for developing the PSSI. All risk factors were assigned multipliers, and the PSSI was the product of those multipliers. Recommendations for improvement are based on the PSSI; however, extensive studies are required to validate their effectiveness. multipliers, and the PSSI was the product of those multipliers. Recommendations for improvement are based on the PSSI; however, extensive studies are required to validate their effectiveness.

Development of a matrix approach to estimate soil clean-up levels for BTEX compounds

International Nuclear Information System (INIS)

Erbas-White, I.; San Juan, C.

1993-01-01

A draft state-of-the-art matrix approach has been developed for the State of Washington to estimate clean-up levels for benzene, toluene, ethylbenzene and xylene (BTEX) in deep soils based on an endangerment approach to groundwater. Derived soil clean-up levels are estimated using a combination of two computer models, MULTIMED and VLEACH. The matrix uses a simple scoring system that is used to assign a score at a given site based on the parameters such as depth to groundwater, mean annual precipitation, type of soil, distance to potential groundwater receptor and the volume of contaminated soil. The total score is then used to obtain a soil clean-up level from a table. The general approach used involves the utilization of computer models to back-calculate soil contaminant levels in the vadose zone that would create that particular contaminant concentration in groundwater at a given receptor. This usually takes a few iterations of trial runs to estimate the clean-up levels since the models use the soil clean-up levels as ''input'' and the groundwater levels as ''output.'' The selected contaminant levels in groundwater are Model Toxic control Act (MTCA) values used in the State of Washington

INFLUENCE OF THE NATURAL ILLUMINATION LEVEL ON THE INDOOR GROWTH AND DEVELOPMENT OF PETUNIA HYBRIDA

Directory of Open Access Journals (Sweden)

B. Lixandru

2004-01-01

Full Text Available In a room with a natural illumination index (NII of 4.79, for 70 days, the influence of three illumination levels on the growth and development process of petunias from the Petunia hybrida species was studied. After rising, plants were placed in three zones of the room with different illumination levels: zone A (683 lx – situated on the window’s sill, zone B (113 lx – situated on the floor, at the base of the parapet, and zone C (376 lx – situated in the center of the room, on a table, at 80 cm from the floor. After two weeks from the pricking out, plants were transplanted in glass pots of 200 ml. At 2, 15, 30, 50 and 70 days the maximum length of the stem, branching level and leaf number were determined. At the end of the experiment and 10 days of room temperature drying, root, stem, leaf and flower biomass quantity was determined. Our results evidence the negative effect of the low illumination level (113 lx and 376 lx on the growth and development process of petunias from the Petunia hybrida species. Being a light and warmth loving plant, P. hybrida may be grown only at well-illuminated windows, with a level of minimum 1000 lx.

Development of a bionanodevice for detecting stress levels

International Nuclear Information System (INIS)

Nomura, S; Handri, S; Honda, H

2011-01-01

Recent advances in molecular analysis techniques have enabled scientists to assess the tiny amounts of biochemical substances secreted in our bodies. This has revealed that the levels of various secretory hormones and immune substances vary sensitively with the mental state of a person. Such hormones and immune substances exhibit transient increases with various psychological stressors. They thus have the potential to be used as a novel biometric for monitoring stress. Biomarkers that occur in saliva can be monitored non-invasively and are thus potentially useful as practical indicators of mental stress. Stress biomarkers are considered to be released into the blood stream or other secretory fluids by physiological stress reactions. Stress biomarkers are expected to be detectable in sweat and other humoral fluids that are exuded from the skin surface. Based on this, we have developed a bionanodevice for detecting stress by capturing stress biomarkers on the skin surface in a non-invasive manner. A prototype bionanodevice is described in which a motor protein is introduced for molecular handling.

Development of a bionanodevice for detecting stress levels

Energy Technology Data Exchange (ETDEWEB)

Nomura, S; Handri, S [Top Runner Incubation Center for Academia-Industry Fusion, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka 940-2188 (Japan); Honda, H, E-mail: nomura@kjs.nagaokaut.ac.jp, E-mail: hhonda@vos.nagaokaut.ac.jp [Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka 940-2188 (Japan)

2011-03-15

Recent advances in molecular analysis techniques have enabled scientists to assess the tiny amounts of biochemical substances secreted in our bodies. This has revealed that the levels of various secretory hormones and immune substances vary sensitively with the mental state of a person. Such hormones and immune substances exhibit transient increases with various psychological stressors. They thus have the potential to be used as a novel biometric for monitoring stress. Biomarkers that occur in saliva can be monitored non-invasively and are thus potentially useful as practical indicators of mental stress. Stress biomarkers are considered to be released into the blood stream or other secretory fluids by physiological stress reactions. Stress biomarkers are expected to be detectable in sweat and other humoral fluids that are exuded from the skin surface. Based on this, we have developed a bionanodevice for detecting stress by capturing stress biomarkers on the skin surface in a non-invasive manner. A prototype bionanodevice is described in which a motor protein is introduced for molecular handling.

Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development

Science.gov (United States)

Beurel, Eléonore; Mines, Marjelo A; Song, Ling; Jope, Richard S

2012-01-01

Objectives Dysregulated glycogen synthase kinase-3 (GSK3) may contribute to the pathophysiology of mood disorders and other diseases, and appears to be a target of certain therapeutic drugs. The growing recognition of heightened vulnerability during development to many psychiatric diseases, including mood disorders, led us to test if there are developmental changes in mouse brain GSK3 and its regulation by phosphorylation and by therapeutic drugs. Methods GSK3 levels and phosphorylation were measured at seven ages of development in mouse cerebral cortex and hippocampus. Results Two periods of rapid transitions in GSK3 levels were identified, a large rise between postnatal day 1 and two to three weeks of age, where GSK3 levels were as high as four-fold adult mouse brain levels, and a rapid decline between two to four and eight weeks of age, when adult levels were reached. Inhibitory serine-phosphorylation of GSK3, particularly GSK3β, was extremely high in one-day postnatal mouse brain, and rapidly declined thereafter. These developmental changes in GSK3 were equivalent in male and female cerebral cortex, and differed from other signaling kinases, including Akt, ERK1/2, JNK, and p38 levels and phosphorylation. In contrast to adult mouse brain, where administration of lithium or fluoxetine rapidly and robustly increased serine-phosphorylation of GSK3, in young mice these responses were blunted or absent. Conclusions High brain levels of GSK3 and large fluctuations in its levels and phosphorylation in juvenile and adolescent mouse brain raise the possibility that they may contribute to destabilized mood regulation induced by environmental and genetic factors. PMID:23167932

Practical appraisal of sustainable development-Methodologies for sustainability measurement at settlement level

International Nuclear Information System (INIS)

Moles, Richard; Foley, Walter; Morrissey, John; O'Regan, Bernadette

2008-01-01

This paper investigates the relationships between settlement size, functionality, geographic location and sustainable development. Analysis was carried out on a sample of 79 Irish settlements, located in three regional clusters. Two methods were selected to model the level of sustainability achieved in settlements, namely, Metabolism Accounting and Modelling of Material and Energy Flows (MA) and Sustainable Development Index Modelling. MA is a systematic assessment of the flows and stocks of material within a system defined in space and time. The metabolism of most settlements is essentially linear, with resources flowing through the urban system. The objective of this research on material and energy flows was to provide information that might aid in the development of a more circular pattern of urban metabolism, vital to sustainable development. In addition to MA, a set of forty indicators were identified and developed. These target important aspects of sustainable development: transport, environmental quality, equity and quality of life issues. Sustainability indices were derived through aggregation of indicators to measure dimensions of sustainable development. Similar relationships between settlement attributes and sustainability were found following both methods, and these were subsequently integrated to provide a single measure. Analysis identified those attributes of settlements preventing, impeding or promoting progress towards sustainability

A Hydro-Economic Model for Water Level Fluctuations: Combining Limnology with Economics for Sustainable Development of Hydropower

Science.gov (United States)

Hirsch, Philipp Emanuel; Schillinger, Sebastian; Weigt, Hannes; Burkhardt-Holm, Patricia

2014-01-01

Water level fluctuations in lakes lead to shoreline displacement. The seasonality of flooding or beaching of the littoral area affects nutrient cycling, redox gradients in sediments, and life cycles of aquatic organisms. Despite the ecological importance of water level fluctuations, we still lack a method that assesses water levels in the context of hydropower operations. Water levels in reservoirs are influenced by the operator of a hydropower plant, who discharges water through the turbines or stores water in the reservoir, in a fashion that maximizes profit. This rationale governs the seasonal operation scheme and hence determines the water levels within the boundaries of the reservoir's water balance. For progress towards a sustainable development of hydropower, the benefits of this form of electricity generation have to be weighed against the possible detrimental effects of the anthropogenic water level fluctuations. We developed a hydro-economic model that combines an economic optimization function with hydrological estimators of the water balance of a reservoir. Applying this model allowed us to accurately predict water level fluctuations in a reservoir. The hydro-economic model also allowed for scenario calculation of how water levels change with climate change scenarios and with a change in operating scheme of the reservoir (increase in turbine capacity). Further model development will enable the consideration of a variety of additional parameters, such as water withdrawal for irrigation, drinking water supply, or altered energy policies. This advances our ability to sustainably manage water resources that must meet both economic and environmental demands. PMID:25526619

A hydro-economic model for water level fluctuations: combining limnology with economics for sustainable development of hydropower.

Science.gov (United States)

Hirsch, Philipp Emanuel; Schillinger, Sebastian; Weigt, Hannes; Burkhardt-Holm, Patricia

2014-01-01

Water level fluctuations in lakes lead to shoreline displacement. The seasonality of flooding or beaching of the littoral area affects nutrient cycling, redox gradients in sediments, and life cycles of aquatic organisms. Despite the ecological importance of water level fluctuations, we still lack a method that assesses water levels in the context of hydropower operations. Water levels in reservoirs are influenced by the operator of a hydropower plant, who discharges water through the turbines or stores water in the reservoir, in a fashion that maximizes profit. This rationale governs the seasonal operation scheme and hence determines the water levels within the boundaries of the reservoir's water balance. For progress towards a sustainable development of hydropower, the benefits of this form of electricity generation have to be weighed against the possible detrimental effects of the anthropogenic water level fluctuations. We developed a hydro-economic model that combines an economic optimization function with hydrological estimators of the water balance of a reservoir. Applying this model allowed us to accurately predict water level fluctuations in a reservoir. The hydro-economic model also allowed for scenario calculation of how water levels change with climate change scenarios and with a change in operating scheme of the reservoir (increase in turbine capacity). Further model development will enable the consideration of a variety of additional parameters, such as water withdrawal for irrigation, drinking water supply, or altered energy policies. This advances our ability to sustainably manage water resources that must meet both economic and environmental demands.

A hydro-economic model for water level fluctuations: combining limnology with economics for sustainable development of hydropower.

Directory of Open Access Journals (Sweden)

Philipp Emanuel Hirsch

Full Text Available Water level fluctuations in lakes lead to shoreline displacement. The seasonality of flooding or beaching of the littoral area affects nutrient cycling, redox gradients in sediments, and life cycles of aquatic organisms. Despite the ecological importance of water level fluctuations, we still lack a method that assesses water levels in the context of hydropower operations. Water levels in reservoirs are influenced by the operator of a hydropower plant, who discharges water through the turbines or stores water in the reservoir, in a fashion that maximizes profit. This rationale governs the seasonal operation scheme and hence determines the water levels within the boundaries of the reservoir's water balance. For progress towards a sustainable development of hydropower, the benefits of this form of electricity generation have to be weighed against the possible detrimental effects of the anthropogenic water level fluctuations. We developed a hydro-economic model that combines an economic optimization function with hydrological estimators of the water balance of a reservoir. Applying this model allowed us to accurately predict water level fluctuations in a reservoir. The hydro-economic model also allowed for scenario calculation of how water levels change with climate change scenarios and with a change in operating scheme of the reservoir (increase in turbine capacity. Further model development will enable the consideration of a variety of additional parameters, such as water withdrawal for irrigation, drinking water supply, or altered energy policies. This advances our ability to sustainably manage water resources that must meet both economic and environmental demands.

TOURISM COMPANIES AND THE FALS PORTRAIT GIVEN BY CREATIVE ACCOUNTING

Directory of Open Access Journals (Sweden)

MARGARETA PENEOAȘU

2014-05-01

Full Text Available Theodore Roosevelt expressed so well the need and effectiveness of natural resources “To waste, to destroy our natural resources, to skin and exhaust the land instead of using it so as to increase its usefulness, will result in undermining in the days of our children the very prosperity which we ought by right to hand down to them amplified and developed” in parallel with his statement that "Human beings are unique in that they can learn from others' experience, but also through its refusal to make use of this capacity". Some companies use the knowledge of professional accountants to manipulate figures contained in the annual accounts, without paying attention to detect when "creativity” exceeds the limits imposed by law. Sometimes, professional accountants are convinced on the one hand by incompetent managers, and on the other hand if the business downturn of the need for improvements in the figures in the annual accounts. When asking why a company with the object of catering and tourism would resort to the practice of using creative accounting, the answer is clear from the application of the trends in the field and from the differences that emerged from the accounting procedures used by companies and the moment they are adopted

FORTUNE TELLINGS THAT RELATED FRUITS / MEYVELERIN DILINDEN FAL VE ISARETLER

Directory of Open Access Journals (Sweden)

Dr. Saadettin EĞRİ

2008-10-01

Full Text Available This study discusses the meanings attributed tovarious fruit in the fortune telling book Hursidname.Hursidname is located in the Library of Manuscripts andAncient Printed Books in Bursa and it’s characteristicsare interesting. It was written in the 18th century bySıdki and it is the only copy. In this book there are 36fruit and plant names. Every fruit’s loacations in the textwere given and all the fruit’s means were defined.Generally in this book there are some expectations andinformations about health, richness, chair, journey,sadness, beauty, pain, life, commerce, friends andenemies. There are good predictions for each person whomake a wish .

Radon levels in dwellings in chalk terrain. Development and analysis of distributional and causal models

International Nuclear Information System (INIS)

Killip, Ian Richmond

2002-01-01

This thesis investigates the range, distribution and causes of high radon levels in dwellings in the Brighton area of Southeast England. Indoor radon levels were measured in more than 1000 homes. The results show that high radon levels can arise in an area previously considered to offer low radon potential from local geological sources. Climate and building-related factors were found to affect significantly the radon levels in dwellings. Multiple regression was used to determine the influence of the various factors on indoor radon levels and an empirical model develop to predict indoor radon levels. The radon hazard, independent of building-related effects, was determined for each surveyed location by adjusting the radon measurement to that expected on the ground floor of a 'model' dwelling. This standardised set of radon levels was entered into a geographical information system (GIS) and related to surface geology. The geometric mean radon level for each lithological unit was plotted to produce a radon hazard map for the area. The highest radon levels were found to be associated with the youngest Chalk Formations, particularly where they meet overlying Tertiary deposits, and with Clay-with-Flints Quaternary deposits in the area. The results were also converted to the radon activity equivalent to that expected from the NRPB's standard dual-detector dwelling survey method and analysed by lognormal modelling to estimate the proportion of dwellings likely to exceed the UK Action Level of 200 Bq/m 3 for each lithological unit. The likely percentages of dwellings affected by radon thus obtained were mapped to lithological boundaries to produce a radon potential map. The radon hazard map and the empirical radon model facilitate the prediction of radon levels in dwellings of comparable construction and above similar geology and should further the understanding of the behaviour of radon gas in buildings to allow indoor radon concentrations to be controlled. The radon

Development of site suitability criteria for the high level waste repository for Lawrence Livermore Laboratories

International Nuclear Information System (INIS)

1977-06-01

Results of our mining, geological and geotechnical studies provided in support of the development of site suitability criteria for the high level waste repository are presented. The primary purpose of the work was the identification and development of appropriate geotechnical descriptors and coefficients required for the Site Suitability Repository Model. This model was developed by The Analytic Sciences Corporation (TASC) of Reading, Massachusetts and is not described in this report

Development of site suitability criteria for the high level waste repository for Lawrence Livermore Laboratories

Energy Technology Data Exchange (ETDEWEB)

1977-06-01

Results of our mining, geological and geotechnical studies provided in support of the development of site suitability criteria for the high level waste repository are presented. The primary purpose of the work was the identification and development of appropriate geotechnical descriptors and coefficients required for the Site Suitability Repository Model. This model was developed by The Analytic Sciences Corporation (TASC) of Reading, Massachusetts and is not described in this report.

Industry-level total-factor energy efficiency in developed countries: A Japan-centered analysis

International Nuclear Information System (INIS)

Honma, Satoshi; Hu, Jin-Li

2014-01-01

Highlights: • This study compares Japan with other developed countries for energy efficiency at the industry level. • We compute the total-factor energy efficiency (TFEE) for industries in 14 developed countries in 1995–2005. • Energy conservation can be further optimized in Japan’s industry sector. • Japan experienced a slight decrease in the weighted TFEE from 0.986 in 1995 to 0.927 in 2005. • Japan should adapt energy conservation technologies from the primary benchmark countries: Germany, UK, and USA. - Abstract: Japan’s energy security is more vulnerable today than it was before the Fukushima Daiichi nuclear power plant accident in March 2011. To alleviate its energy vulnerability, Japan has no choice but to improve energy efficiency. To aid in this improvement, this study compares Japan’s energy efficiency at the industry level with that of other developed countries. We compute the total-factor energy efficiency (TFEE) of industries in 14 developed countries for 1995–2005 using data envelopment analysis. We use four inputs: labor, capital stock, energy, and non-energy intermediate inputs. Value added is the only relevant output. Results indicate that Japan can further optimize energy conservation because it experienced only a marginal decrease in the weighted TFEE, from 0.986 in 1995 to 0.927 in 2005. To improve inefficient industries, Japan should adapt energy conservation technologies from benchmark countries such as Germany, the United Kingdom, and the United States

Effects of dietary nicotine on the development of an insect herbivore, its parasitoid and secondary hyperparasitoid over four trophic levels

NARCIS (Netherlands)

Harvey, J.A.; Dam, van N.M.; Witjes, L.M.A.; Soler, R.; Gols, R.

2007-01-01

1. Allelochemicals in herbivore diet are known to affect the development of higher trophic levels, such as parasitoids and predators. 2. This study examines how differing levels of nicotine affects the development of a herbivore, its parasitoid and secondary hyperparasitoid over four trophic levels.

Behavioral and Cardiac Responses to a Sudden Change in Environmental Stimuli : Effect of Forced Shift in Food Intake

NARCIS (Netherlands)

Steenbergen, J.M.; Koolhaas, J.M.; Strubbe, J.H.; Bohus, B.

In order to test the possibility of a change in stress susceptibility induced by a forced change in activity rhythm, during control weeks food availability was restricted to the dark period only (fa-D) and to the light period only during the test week (fa-L). Stress susceptibility was measured on

Effectively digitizing communication with Turnitin for improved ...

African Journals Online (AJOL)

Electronic interviews with learners and focus group discussions in a specially created chat room with other FAL teachers in the school were conducted to collect data. ... Findings indicate that the innovative application of Turnitin, a tool that provides a similarity index, to provide written corrective feedback (WCF), started an ...

TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update.

Science.gov (United States)

Lattante, Serena; Rouleau, Guy A; Kabashi, Edor

2013-06-01

Mutations in the TAR DNA Binding Protein gene (TARDBP), encoding the protein TDP-43, were identified in amyotrophic lateral sclerosis (ALS) patients. Interestingly, TDP-43 positive inclusion bodies were first discovered in ubiquitin-positive, tau-negative ALS and frontotemporal dementia (FTD) inclusion bodies, and subsequently observed in the majority of neurodegenerative disorders. To date, 47 missense and one truncating mutations have been described in a large number of familial (FALS) and sporadic (SALS) patients. Fused in sarcoma (FUS) was found to be responsible for a previously identified ALS6 locus, being mutated in both FALS and SALS patients. TARDBP and FUS have a structural and functional similarity and most of mutations in both genes are also clustered in the C-terminus of the proteins. The molecular mechanisms through which mutant TDP-43 and FUS may cause motor neuron degeneration are not well understood. Both proteins play an important role in mRNA transport, axonal maintenance, and motor neuron development. Functional characterization of these mutations in in vitro and in vivo systems is helping to better understand how motor neuron degeneration occurs. This report summarizes the biological and clinical relevance of TARDBP and FUS mutations in ALS. All the data reviewed here have been submitted to a database based on the Leiden Open (source) Variation Database (LOVD) and is accessible online at www.lovd.nl/TARDBP, www.lovd.nl/FUS. © 2013 Wiley Periodicals, Inc.

Development of the clearance level verification evaluation system. 2. Construction of the clearance data management system

International Nuclear Information System (INIS)

Kubota, Shintaro; Usui, Hideo; Kawagoshi, Hiroshi

2014-06-01

Clearance is defined as the removal of radioactive materials or radioactive objects within authorized practices from any further regulatory control by the regulatory body. In Japan, clearance level and a procedure for its verification has been introduced under the Laws and Regulations, and solid clearance wastes inspected by the national authority can be handled and recycled as normal wastes. The most prevalent type of wastes have generated from the dismantling of nuclear facilities, so the Japan Atomic Energy Agency (JAEA) has been developing the Clearance Level Verification Evaluation System (CLEVES) as a convenient tool. The Clearance Data Management System (CDMS), which is a part of CLEVES, has been developed to support measurement, evaluation, making and recording documents with clearance level verification. In addition, validation of the evaluation result of the CDMS was carried out by inputting the data of actual clearance activities in the JAEA. Clearance level verification is easily applied by using the CDMS for the clearance activities. (author)

Research and development plans for disposal of high-level and transuranic wastes

International Nuclear Information System (INIS)

Bartlett, J.W.; Platt, A.M.

1978-09-01

This plan recommends a 20-year, 206 million (1975 $'s) R and D program on geologic structures in the contiguous U.S. and on the midplate Pacific seabed with the objective of developing an acceptable method for disposal of commercial high-level and transuranic wastes by 1997. No differentiation between high-level and transuranic waste disposal is made in the first 5 years of the program. A unique application of probability theory to R and D planning establishes, at a 95% confidence level, that the program objective will be met if at least fifteen generic options and five specific disposal sites are explored in detail and at least two pilot plants are constructed and operated. A parallel effort on analysis and evaluation maximizes information available for decisions on the acceptability of the disposal techniques. Based on considerations of technical feasibility, timing and technical risk, the other disposal concepts, e.g., ice sheets, partitioning, transmutation and space disposal cited in BNWL-1900 are not recommended for near future R and D

Development and verification for review plan of emergency action level (EAL)

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-08-15

Emergency action levels (EALs) are used as the trigger in order to implement the precautionary protective actions at the nuclear emergency. In this study the framework for applying the EAL in Japan and the process for developing the review plan, such as procedures to review the basis of EAL submitted by the licensee, have been investigated based on the survey for EAL review executed in the United States. In addition, issues to reflect the EAL framework in enhancement of the local government emergency planning and emergency response support system have been investigated. (author)

Development of a computerized data base for low-level waste leaching data

International Nuclear Information System (INIS)

Dougherty, D.R.; Colombo, P.

1987-01-01

A computerized data base (db) of low-level waste (LLW) leaching data is being compiled by Brookhaven National Laboratory under contract to the DOE Low-Level Waste Management Program. Although this db is being compiled as part of an effort to develop accelerated leach test procedures for LLW forms, other involved in LLW management may find it useful. The db is implemented on an IBM PC XT and is self-contained in that its data manipulation and analysis programs are not proprietary (i.e., need not be purchased). The db includes data from the Accelerated Leach Test(s) Program plus selected literature data, which have been selected based on criteria that include completeness of the experimental description and elucidation of leaching mechanisms. 6 references, 5 figures, 3 tables

A three-level approach to quality programs for research, development, and production

International Nuclear Information System (INIS)

Davis, A.H.; Bussolini, P.L.; Geoffrion, R.R.

1986-01-01

A primary mission of the Los Alamos National Laboratory is to develop nuclear weapons systems for the Department of Defense. The activities included in this effort cover a broad spectrum ranging from pure research to routine production. In order to provide a workable framework for a comprehensive quality assurance program for these varied activities, the authors have proposed a three-level structure of quality plans, corresponding to a rough classification of the weapons work into three general categories. These categories are: 1) research into materials and processes, and preliminary development; 2) design, development, and fabrication of prototype components; 3) routine production, analysis, or refinement activities. The first category requires a quality program to assure the validity, reliability, and retrievability of the information developed; this is accomplished by a conscientious application of what is generally recognized as good laboratory practice. The second category requires in addition a strong emphasis on design review and inspection. For the third category, a comprehensive quality program is appropriate, following the general guidelines of NQA-1

Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals

NARCIS (Netherlands)

Maijer, Karen I.; Neumann, Elena; Müller-Ladner, Ulf; Drop, Daniël A. C. A. D.; Ramwadhdoebe, Tamara H.; Choi, Ivy Y. K.; Gerlag, Daniëlle M.; de Hair, Maria J. H.; Tak, Paul P.

2015-01-01

We have previously shown that overweight may increase the risk of developing rheumatoid arthritis (RA) in autoantibody positive individuals. Adipose tissue could contribute to the development of RA by production of various bioactive peptides. Therefore, we examined levels of adipokines in serum and

THE THEORETICAL AND METHODICAL APPROACH TO AN ASSESSMENT OF A LEVEL OF DEVELOPMENT OF THE ENTERPRISE IN CONDITIONS OF GLOBALIZATION

Directory of Open Access Journals (Sweden)

Tatiana Shved

2016-11-01

Full Text Available The subject of this article is theoretical, methodical and practical aspects of enterprise development in conditions of globalization. The purpose of this research is to provide theoretical and methodical approach to an assessment of a level of development of the enterprise, which is based on the relationship between the factors and influence, illustrating the effect of the internal and external environment of enterprises functioning, and indicates the level of development of the enterprise. Methodology. Theoretical basis of the study was the examination and rethinking of the main achievements of world and domestic science on the development of enterprises. To achieve the objectives of the research following methods were used: systemic and structural analysis for the formation of methodical approaches to the selection of the factors, influencing the development of enterprises; abstract and logical – for the formulation of conclusions and proposals; the method of valuation and expert assessments to the implementation of the proposed theoretical and methodical approach to an assessment of a level of development of the enterprise in conditions of globalization. Results of the research is the proposed theoretical and methodical to an assessment of a level of development of the enterprise in conditions of globalization, which is associated with the idea of development of the enterprise as a system with inputs–factors, influencing on the development , and outputs – indicators of the level of enterprise development within these factors. So, the chosen factors – resources, financial-economic activity, innovation and investment activities, competition, government influence, and foreign trade. Indicators that express these factors, are capital productivity, labour productivity, material efficiency within the first factor; the profitability of the activity, the coefficient of current assets, the total liquidity coefficient, financial stability

DNA endoreplication level in endosperm during seed development in three monocotyledonous species

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Kazimierz Marciniak

2014-01-01

Full Text Available The DNA content after the Feulgen reaction in the endosperm of three monocotyledonous plant species (Asparagus officinalis, Muscari comosom, Haemanthus kurharinae differing in their 2C DNA content, was cytophotometrically measured. During endosperm development 1-6 endoreplication cycles take place, depending on the species. Differences in nuclear DNA endoreplication dynamics in the tested species are similar to those occurring in root parenchyma, but the endoreplication level in the endosperm is higher.

Developing the level of adoption survey to inform collaborative discussion regarding educational innovation

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Doug Orr

2010-05-01

Full Text Available Learning organizations rely on collaborative information and understanding to support and sustain professional growth and development. A collaborative self-assessment instrument can provide clear articulation and characterization of the level of adoption of innovation such as the use of instructional technologies. Adapted from the “Level of Use” (LoU and “Stages of Concern” indices, the Level of Adoption (LoA survey was developed to assess changes in understanding of and competence with emerging and innovative educational technologies. The LoA survey, while reflecting the criteria and framework of the original LoU from which it was derived, utilizes a specifically structured on-line, self-reporting scale of “level of adoption” to promote collaborative self-reflection and discussion. Growth in knowledge of, and confidence with, specific emergent technologies is clearly indicated by the results of this pilot study, thus supporting the use of collaborative reflection and assessment to foster personal and systemic professional development. Résumé : Les organisations apprenantes s’appuient sur des informations et une compréhension issues de la collaboration afin de soutenir et d’entretenir la croissance et le perfectionnement professionnels. Un instrument d’auto-évaluation collaboratif permet d’articuler et de caractériser de manière explicite le niveau d’adoption des innovations, comme l’utilisation de technologies éducatives, par exemple. Adapté à partir des indices de « niveau d’utilisation » (ou « LoU » pour Level of Use et de « niveaux de préoccupation », l’instrument d’enquête sur le niveau d’adoption (ou « LoA » pour Level of Adoption a été conçu afin d’évaluer les changements qui surviennent dans la compréhension des technologies éducatives émergentes et innovatrices ainsi que dans les compétences relatives à ces technologies. L’instrument d’enquête LoA, bien qu’il refl

High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men.

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Jieun Lee

Full Text Available We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138 of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (p< 0.001. As the hs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range may require appropriate follow-up and management to prevent NAFLD development.

Issue of Building Information Modelling Implementation into the Czech Republic’s Legislation using the Level of Development

Science.gov (United States)

Prušková, Kristýna; Nývlt, Vladimír

2017-10-01

The object of this paper is the issue of links between the Level of Development of particular project in Building Information Modeling environment and the projects of certain stages of project documentation within the existing Czech Republic’s Legislation. This research article uses the experiences from the initiative of active working group „WG#03: BIM & Realization“, which is the part of the Czech BIM Council, especially the document called “Draft of unified data structure for Building Information Modeling in the Czech Republic”. The findings of this paper are in the defining specific Level of Development of relative parameters, mentioned in this document, connected to the specific level of information and details requested by the Czech Republic’s Legislation. These findings could be used as an underlay to create document called “Level of Development draft assignment to the individual stages of project documentation in the Czech Republic”. The Level of Development is the most useful way of the information visualization, which leads to the most effortless way of exact stated implementation of Building Information Modeling into the practice of designing structures and buildings in the Czech Republic. The Implementation of using Building Information Modeling technology in designing structures and buildings will lead to the enhanced quality of the project documentation and generally to more effective cost savings during whole life cycle of buildings. Moreover, the all over using of the BIM technology in the Czech Republic will be very useful in the Facility Management area, especially in the facility management and maintenance of state buildings.

Evaluating the level and nature of sustainable development for a geothermal power plant

International Nuclear Information System (INIS)

Phillips, Jason

2010-01-01

The paper provides for an evaluation of the potential level and nature of sustainable development of the Sabalan geothermal power plant in NW Iran, to be operational in 2011. The paper achieves this by applying a mathematical model of sustainable development developed by the author (re: Phillips), in respect to the Environmental Impact Assessment (EIA) conducted by Yousefi et al. using the Rapid Impact Assessment Matrix (RIAM) methodology (re: Pastakia; Pastakia and Jensen). Using a model application methodology developed for the RIAM, the results indicated that the nature of sustainable development for Sabalan was considered to be very weak (S = 0.063). This was due to the imbalance between negative environmental impacts and positive socio-economic impacts deriving from the project. Further, when placed into context with a similar set of results obtained from the EIA of the Tuzla geothermal power plant by Baba also using the RIAM methodology, then the similarities between the results obtained raises some legimate questions as to the sustainable development credentials of geothermal power production. (author)

Synoptic climatology of the long-distance dispersal of white pine blister rust I. Development of an upper level synoptic classification

Science.gov (United States)

K. L. Frank; L. S. Kalkstein; B. W. Geils; H. W. Thistle

2008-01-01

This study developed a methodology to temporally classify large scale, upper level atmospheric conditions over North America, utilizing a newly-developed upper level synoptic classification (ULSC). Four meteorological variables: geopotential height, specific humidity, and u- and v-wind components, at the 500 hPa level over North America were obtained from the NCEP/NCAR...

Development of criteria and standards for management of low-level radioactive waste

International Nuclear Information System (INIS)

Grey, A.E.; Falconer, K.L.

1980-08-01

The basic need for criteria and standards for radioactive waste management is to ensure compliance with Federal and State regulations applicable to this activity. In addition, criteria and standards can establish the parameters by which a radioactive waste disposal site is selected, the form in which the waste is to be disposed, how a disposal site is to be operated, and how that site is to be closed when it reaches the end of its useful life. For developing criteria and standards, this report discusses the nature of low-level radioactive waste and the role government agencies play in regulating its management. It describes subject areas for which criteria and standards could be developed, current and evolving requirements, and future suggested analyses

Low-level radioactive waste source term model development and testing: Topical report

International Nuclear Information System (INIS)

Sullivan, T.M.; Kempf, C.R.; Suen, C.J.; Mughabghab, S.M.

1988-08-01

The Low-Level Waste Source Term Evaluation Project has the objective to develop a system model capable of predicting radionuclide release rates from a shallow land burial facility. The previous topical report for this project discussed the framework and methodology for developing a system model and divided the problem into four compartments: water flow, container degradation, waste form leaching, and radionuclide transport. Each of these compartments is described by submodels which will be coupled into the system model. From February 1987 to March 1988, computer models have been selected to predict water flow (FEMWATER) and radionuclide transport (FEMWASTE) and separate models have been developed to predict pitting corrosion of steel containers and leaching from porous waste forms contained in corrodible containers. This report discusses each of the models in detail and presents results obtained from applying the models to shallow land burial trenches over a range of expected conditions. 68 refs., 34 figs., 14 tabs

RESEARCH OF THE LEVEL OF THE INNOVATIVE DEVELOPMENT OF THE MACHINE BUILDING ENTERPRISES OF UKRAINE IN KHARKOV REGION

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Kateryna Koliedina

2015-11-01

Full Text Available In today’s world of the science and new technologies development all the countries including Ukraine are entrusted with a task of refocusing on the innovative way of evolution. The level of innovativeness of the country depends on the development of enterprises in this regard since exactly the industrial enterprises are able to induce the innovative process and be a multiplier of other economic sectors. Thus it is expedient to re-equip the industry of the state and encourage exactly the high-tech branches thereof. In this regard the goal of this paper is to explore and assess the influence of the criteria of innovative activity of the industrial enterprises on the level of the innovative development thereof. To reach the mentioned goal the criteria of innovative activity of the leading machine building enterprises of Ukraine in Kharkov region are chosen as the object of research. The studied enterprises are innovatively active in Kharkov region according to the criteria of the work thereof. The following criteria of innovative activity of the enterprises are chosen for analysis: the volume of the sold innovative products; the charges for innovation; the research intensity of the innovative products; the share of the studied enterprises in the total volume of the products sold in this region; the quantity of the new technological processes; the quantity of the new innovative kinds of products. The chosen criteria are important for enterprise in relation to the innovative activity and in case of changes have a substantial influence on its development and stability. Methodology. To research the level of innovative development of the machine building enterprises of Ukraine in Kharkov region the author prop: 1 Formation of the matrix of the basic data; 2 Standardization of the basic data; 3 Differentiation of the characteristics on inciters and disincentives; 4 Construction of the etalon; 5 Determination of the distance between the objects and

Effects of Individual and School-Level Characteristics on a Child’s Gross Motor Coordination Development

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Raquel Chaves

2015-07-01

Full Text Available The aim of this study was to identify child and school-level characteristics that explained inter-individual differences in gross motor coordination (GMC. Participants (n = 390, recruited from 18 Portuguese primary schools, were aged 6 to 10 years of age. Birth weight, body fat (BF, physical activity (PA, physical fitness (PF and GMC were assessed. School size, setting, infrastructure and physical education classes were considered as school context markers. A multilevel modeling approach was used to identify hierarchical effects (child and school levels. It was found that children-level variables (sex, PF, and BF significantly explained 63% of the 90% variance fraction at the individual level; boys outperformed girls (p < 0.05, individuals with higher BF were less coordinated (p < 0.05, and those with higher PF were more coordinated (p < 0.05. School-variables (e.g. school size and playing surface explained 84% of the 10% variation fraction. These findings confirm the roles of sex, PFS and BF. Interestingly they also suggest that the school environment plays a minor but significant role in GMC development. However, it is important to stress that the school context and conditions can also play an important role in a child’s motor development, providing adequate and enriching motor opportunities.

Empirical Research on Ecological Development Level of Resource-based Industries-Base on the data of the Silk Road Economic Belt Core Zone

Science.gov (United States)

Wang, Lei; Yan, Min

2017-11-01

Industrial ecology is the epitome of sustainable development in industry level, is one effective gateway to realizing green transformation. On the basis of industrial ecology development, including resource efficiency and environmental efficiency of ecological evaluation index system, this paper evaluates the level of industrial ecology development of resource-based industries in Xinjiang using entropy method. Research shows that the overall ecological development level of resource-based industries has remained at continuous improved trend with slow improvement in resource efficiency, and relative faster improvement in environmental efficiency. With economic development entering into the period of new normal at the end of the “twelfth five year plan”, the resource efficiency of ecological development of resource-based industries demonstrated a downward trend. The overall level of industrial ecology also faced with certain fluctuations, various ecological development level of resource-based industries also presented a downward trend. To promote ecological development of resource-based industries in Xinjiang, countermeasures and suggestions are initiated.

Comprehensive development plans for the low- and intermediate-level radioactive waste disposal facility in Korea and preliminary safety assessment

Energy Technology Data Exchange (ETDEWEB)

Jung, Kang Il; Kim, Jin Hyeong; Kwon, Mi Jin; Jeong, Mi Seon; Hong, Sung Wook; Park, Jin Beak [Korea Radioactive Waste Agency, Daejeon (Korea, Republic of)

2016-12-15

The disposal facility in Gyeongju is planning to dispose of 800,000 packages of low- and intermediate- level radioactive waste. This facility will be developed as a complex disposal facility that has various types of disposal facilities and accompanying management. In this study, based on the comprehensive development plan of the disposal facility, a preliminary post-closure safety assessment is performed to predict the phase development of the total capacity for the 800,000 packages to be disposed of at the site. The results for each scenario meet the performance target of the disposal facility. The assessment revealed that there is a significant impact of the inventory of intermediate-level radionuclide waste on the safety evaluation. Due to this finding, we introduce a disposal limit value for intermediate-level radioactive waste. With stepwise development of safety case, this development plan will increase the safety of disposal facilities by reducing uncertainties within the future development of the underground silo disposal facilities.

Recent developments in the extraction separation method for treatment of high-level liquid waste

International Nuclear Information System (INIS)

Jiao Rongzhou; Song Chongli; Zhu Yongjun

2000-01-01

A description and review of the recent developments in the extraction separation method for partitioning transuranium elements from high-level liquid waste (HLLW) is presented. The extraction separation processes such as TRUEX process, DIAMEX process, DIDPA process, CTH process, TRPO process are briefly discussed

Development of low-level radioactive waste disposal capacity in the United States - progress or stalemate?

International Nuclear Information System (INIS)

Devgun, J.S.; Larson, G.S.

1995-01-01

It has been fifteen years since responsibility for the disposal of commercially generated low-level radioactive waste (LLW) was shifted to the states by the United States Congress through the Low-Level Radioactive Waste Policy Act of 1980 (LLRWPA). In December 1985, Congress revisited the issue and enacted the Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA). No new disposal sites have opened yet, however, and it is now evident that disposal facility development is more complex, time-consuming, and controversial than originally anticipated. For a nation with a large nuclear power industry, the lack of availability of LLW disposal capacity coupled with a similar lack of high-level radioactive waste disposal capacity could adversely affect the future viability of the nuclear energy option. The U.S. nuclear power industry, with 109 operating reactors, generates about half of the LLW shipped to commercial disposal sites and faces dwindling access to waste disposal sites and escalating waste management costs. The other producers of LLW - industries, government (except the defense related research and production waste), academic institutions, and medical institutions that account for the remaining half of the commercial LLW - face the same storage and cost uncertainties. This paper will summarize the current status of U.S. low-level radioactive waste generation and the status of new disposal facility development efforts by the states. The paper will also examine the factors that have contributed to delays, the most frequently suggested alternatives, and the likelihood of change

Development of low-level radioactive waste disposal capacity in the United States -- Progress or stalemate?

International Nuclear Information System (INIS)

Devgun, J.S.

1995-01-01

It has been fifteen years since responsibility for the disposal of commercially generated low-level radioactive waste (LLW) was shifted to the states by the United States Congress through the Low-Level Radioactive Waste Policy Act of 1980 (LLRWPA). In December 1985, Congress revisited the issue and enacted the Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA). No new disposal sites have opened yet, however, and it is now evident that disposal facility development is more complex, time-consuming, and controversial than originally anticipated. For a nation with a large nuclear power industry, the lack of availability of LLW disposal capacity coupled with a similar lack of high-level radioactive waste disposal capacity could adversely affect the future viability of the nuclear energy option. The US nuclear power industry, with 109 operating reactors, generates about half of the LLW shipped to commercial disposal sites and faces dwindling access to waste disposal sites and escalating waste management costs. The other producers of LLW -- industries, government (except the defense related research and production waste), academic institutions, and medical institutions that account for the remaining half of the commercial LLW -- face the same storage and cost uncertainties. This paper will summarize the current status of US low-level radioactive waste generation and the status of new disposal facility development efforts by the states. The paper will also examine the factors that have contributed to delays, the most frequently suggested alternatives, and the likelihood of change

Development of ICP-AES based method for the characterization of high level waste

International Nuclear Information System (INIS)

Seshagiri, T.K.; Thulsidas, S.K.; Adya, V.C.; Kumar, Mithlesh; Radhakrishnan, K.; Mary, G.; Kulkarni, P.G.; Bhalerao, Bharti; Pant, D.K.

2011-01-01

An Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) method was developed for the trace metal characterization of high level waste solutions (HLW) of different origin and the method was validated by analysis of synthetic samples of simulated high level waste solutions (SHLW) from spent fuels of varying composition. In this context, an inter-laboratory comparison exercise (ILCE) was carried out with the simulated HLW of different spent fuel types, viz., research reactor (RR), pressurized heavy water reactor (PHWR) and fast breeder reactor (FBR). An over view of the ICP-AES determination of trace metallic constituents in such SHLW solutions is presented. The overall agreement between the various laboratories was good. (author)

The Study of Level of Ethical Development in Nurses Working in Training- Treatment Hospitals Affiliated in Tabriz University of Medical Sciences, Tabriz, Iran

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Zirak M

2012-09-01

Full Text Available Background and Objectives: Nurses in their daily practice need acceptable level of ethical development. There is few literature about ethical development of Iranian nurses. The aims of present study are to determine the level ethical development in nurses and its related factors.Methods: This descriptive-correlational study conducted in 2010. The study sample consisted of 269 nurses working in three training-treatment hospitals affiliated to Tabriz University of Medical Sciences. These nurses selected by census sampling method. For assessing the ethical development of nurses, nursing dilemma test was used. This questionnaire was designed based on Kohlbergs’ theory of ethical development and assessed ethical development in pre-convetional, conventional and post-convetional levels. The data analysis was done by descriptive and inferential statistics. Results: Forty four nurses (16.3% were in pre-conventional level, 86 nurses (31.8% were in conventional level, 116 nurses (43.1% were in post-conventional level, and 23 nurses (8.5% were in clinical consideration level. There was negative significant correlation between ethical development of nurses with their job experience. Conclusion: In spite of this fact that near half of nurses are at postconventional level, but still a significant number of them are at lower levels of ethical development. These findings indicate that nursing managers should pay more attention to ethical development of nurses.

Corrective Action Investigation Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Patrick Matthews

2011-09-01

Corrective Action Unit 366 comprises the six corrective action sites (CASs) listed below: (1) 11-08-01, Contaminated Waste Dump No.1; (2) 11-08-02, Contaminated Waste Dump No.2; (3) 11-23-01, Radioactively Contaminated Area A; (4) 11-23-02, Radioactively Contaminated Area B; (5) 11-23-03, Radioactively Contaminated Area C; and (6) 11-23-04, Radioactively Contaminated Area D. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed July 6, 2011, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 366. The presence and nature of contamination at CAU 366 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose (TED) at sample locations to the dose-based final action level (FAL). The TED will be calculated by summing the estimates of internal and external dose. Results from the analysis of soil samples collected from sample plots will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at each sample location will be used to measure external radiological dose. Based on historical documentation of the releases

Corrective Action Investigation Plan for Corrective Action Unit 104: Area 7 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Patrick Matthews

2011-08-01

of the total effective dose (TED) to the dose-based final action level (FAL). The presence of TED exceeding the FAL is considered a radiological contaminant of concern (COC). Anything identified as a COC will require corrective action. The TED will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological dose. Thermoluminescent dosimeters will be used to measure external radiological dose. Based on process knowledge of the releases associated with the nuclear tests and radiological survey information about the location and shape of the resulting contamination plume, it was determined that the releases from the nuclear tests are co-located and will be investigated concurrently. A field investigation will be performed to define areas where TED exceeds the FAL and to determine whether other COCs are present at the site. The investigation will also collect information to determine the presence and nature of contamination associated with migration and excavation, as well as any potential releases discovered during the investigation. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS.

Corrective Action Investigation Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites, Nevada National Security Site, Nevada

International Nuclear Information System (INIS)

Matthews, Patrick

2011-01-01

Corrective Action Unit 366 comprises the six corrective action sites (CASs) listed below: (1) 11-08-01, Contaminated Waste Dump No.1; (2) 11-08-02, Contaminated Waste Dump No.2; (3) 11-23-01, Radioactively Contaminated Area A; (4) 11-23-02, Radioactively Contaminated Area B; (5) 11-23-03, Radioactively Contaminated Area C; and (6) 11-23-04, Radioactively Contaminated Area D. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed July 6, 2011, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 366. The presence and nature of contamination at CAU 366 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose (TED) at sample locations to the dose-based final action level (FAL). The TED will be calculated by summing the estimates of internal and external dose. Results from the analysis of soil samples collected from sample plots will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at each sample location will be used to measure external radiological dose. Based on historical documentation of the releases

Development of a 60Co radioactive rod source used for γ-ray level gauge

International Nuclear Information System (INIS)

Lin Yibing; Pan Liangcai; Yin Shunjiu

1991-09-01

The installation of level gauge used for urea stripping tower, the structure and forming of radioactive rod source, and the calculation of its approximate linear graduation are described. The theoretical and practical feasibility has been confirmed from the test results of comparing the imported radioactive rod source to the developed radioactive rod source. The technological process of production, method for obtaining distribution of radioactivity along the axis, and the test and operation of developed rod source on site are also presented

Evaluation Of Some Blood Biochemical And Hormonal Levels During Different Ages Of Ostrich Embryonic Development

International Nuclear Information System (INIS)

ELSAYED, M.A.; FARGHALY, H.A.M.; MAHROSE, KH.

2010-01-01

Eighty ostrich eggs were collected from the breeding flock at the ostrich farm in the Nuclear Research Centre, Atomic Energy Authority, Inshas, Sharkia Governorate, Egypt, during the period from March to May 2008 to evaluate some blood constituents during ostrich embryonic development. All adult birds were kept under the same managerial, hygienic and environmental conditions and had 2.1 kg palletized feed per bird per day. Eggs were collected at 15.00 pm each day. Eggs were washed and weighed on an electric balance(±)0.01 g.The eggs were placed in the setter for 39 days at 36.5 0 C and 25 % relative humidity. After 39 days, eggs were transferred to hatcher machine at 35.5 0 C and 40 - 45 % relative humidity until hatch. Blood samples were collected at days 21, 28, 35 and 39 of embryonic development and at one day age after 12 hours of hatch. Serum total protein, albumin, globulin, creatinine, urea and uric acid levels were determined. Serum aspartate transaminase and alanine transaminase, total cholesterol, triglycerides and triiodothyronine levels were estimated. The results showed that chicks of one day old and older embryos of ostriches had significant higher values of serum blood components than younger embryos.On the other hand, blood serum cholesterol level was decreased significantly with age advancement during embryonic development and as well as chicks of one day old.

Design, Development and Testing of a Semi Cylindrical Capacitive Sensor for Liquid Level Measurement

Directory of Open Access Journals (Sweden)

Sagarika PAL

2010-05-01

Full Text Available In the present paper a low cost noncontact semi cylindrical capacitive type liquid level sensor has been designed, developed and tested. The semi cylindrical capacitive sensor consisting of two thin semi cylindrical metal plates separated by a gap distance and mounted around a non conducting storage tank, has been used to measure the liquid level in the tank. The measured capacitance variation with variation of liquid level is linear and obtained in the nano farad range which again has been converted into voltage variation by using proper signal conditioning circuit. Since the sensor is noncontact type it can be used for both conducting and non conducting type of liquid contained within a non conducting tank. For converting the capacitance variation in to voltage variation a series R-L-C resonating circuit has been used instead of conventional bridge circuit. Experimental results confirm the satisfactory performance of the sensor for liquid level measurement.

Development, Characterization, and Optimization of Protein Level in Date Bars Using Response Surface Methodology

Directory of Open Access Journals (Sweden)

Muhammad Nadeem

2012-01-01

Full Text Available This project was designed to produce a nourishing date bar with commercial value especially for school going children to meet their body development requirements. Protein level of date bars was optimized using response surface methodology (RSM. Economical and underutilized sources, that is, whey protein concentrate and vetch protein isolates, were explored for protein supplementation. Fourteen date bar treatments were produced using a central composite design (CCD with 2 variables and 3 levels for each variable. Date bars were then analyzed for nutritional profile. Proximate composition revealed that addition of whey protein concentrate and vetch protein isolates improved the nutritional profile of date bars. Protein level, texture, and taste were considerably improved by incorporating 6.05% whey protein concentrate and 4.35% vetch protein isolates in date bar without affecting any sensory characteristics during storage. Response surface methodology was observed as an economical and effective tool to optimize the ingredient level and to discriminate the interactive effects of independent variables.

ANXA11 mutations prevail in Chinese ALS patients with and without cognitive dementia.

Science.gov (United States)

Zhang, Kang; Liu, Qing; Liu, Keqiang; Shen, Dongchao; Tai, Hongfei; Shu, Shi; Ding, Qingyun; Fu, Hanhui; Liu, Shuangwu; Wang, Zhili; Li, Xiaoguang; Liu, Mingsheng; Zhang, Xue; Cui, Liying

2018-06-01

To investigate the genetic contribution of ANXA11 , a gene associated with amyotrophic lateral sclerosis (ALS), in Chinese ALS patients with and without cognitive dementia. Sequencing all the coding exons of ANXA11 and intron-exon boundaries in 18 familial amyotrophic lateral sclerosis (FALS), 353 unrelated sporadic amyotrophic lateral sclerosis (SALS), and 12 Chinese patients with ALS-frontotemporal lobar dementia (ALS-FTD). The transcripts in peripheral blood generated from a splicing mutation were examined by reverse transcriptase PCR. We identified 6 nonsynonymous heterozygous mutations (5 novel and 1 recurrent), 1 splice site mutation, and 1 deletion of 10 amino acids (not accounted in the mutant frequency) in 11 unrelated patients, accounting for a mutant frequency of 5.6% (1/18) in FALS, 2.3% (8/353) in SALS, and 8.3% (1/12) in ALS-FTD. The deletion of 10 amino acids was detected in 1 clinically undetermined male with an ALS family history who had atrophy in hand muscles and myotonic discharges revealed by EMG. The novel p. P36R mutation was identified in 1 FALS index, 1 patient with SALS, and 1 ALS-FTD. The splicing mutation (c.174-2A>G) caused in-frame skipping of the entire exon 6. The rest missense mutations including p.D40G, p.V128M, p.S229R, p.R302C and p.G491R were found in 6 unrelated patients with SALS. The ANXA11 gene is one of the most frequently mutated genes in Chinese patients with SALS. A canonical splice site mutation leading to skipping of the entire exon 6 further supports the loss-of-function mechanism. In addition, the study findings further expand the ANXA11 phenotype, first highlighting its pathogenic role in ALS-FTD.

DINÂMICA GEOMORFOLÓGICA DA COSTA ROCHOSA DO ESTADO DO RIO DE JANEIRO

Directory of Open Access Journals (Sweden)

Antonio Paulo Faria

2018-01-01

Full Text Available Este trabalho sugere a classificação de seis tipos de costão marinho, sete tipos de falésia, bancada e três formas de campo de blocos costeiro, de acordo com as características da geomorfologia costeira brasileira. Aponta ainda para os problemas que podem ocorrer com a ocupação e uso das faixas de lavagem das ondas, que constituem áreas de risco. A maior parte do litoral do Estado do Rio de Janeiro é formada por costões, cuja inclinação é classificada neste trabalho entre 15° e 45°. Acima deste limite é considerado falésia. Existem ainda extensos depósitos de blocos produzindo situações antagônicas: muitos foram originados por eventos catastróficos, mas posteriormente passaram a promover certa proteção à costa, por formar barreiras que dissipam a energia das ondas. Em geral, os costões marinhos nas áreas expostas às ondas de tempestades possuem inclinação média de 30° e comprimento médio de 50m. A extensão aumenta à medida que a inclinação da encosta diminui porque as ondas alcançam áreas mais distantes. Nas áreas semi expostas e protegidas, os comprimentos diminuem. No Estado foram identificadas 13 regiões costeiras distintas, entretanto, da divisa Oeste até a Ilha da Marambaia são comuns depósitos de blocos; nos municípios do Rio de Janeiro e Niterói predominam costões marinhos; entre Arraial do Cabo e Búzios, prevalecem falésias cristalinas; e entre Rio das Ostras e Macaé, o perfil do tipo bancada é o mais comum.

Storytelling as an approach to evaluate the child's level of speech development

Directory of Open Access Journals (Sweden)

Ljubica Marjanovič Umek

2004-05-01

Full Text Available Both in developmental psychology and in linguistics, the child's storytelling is an interesting topic of research from the point of view of evaluating the child's level of speech development, especially of its pragmatic component, and from the point of view of teaching and learning in the preschool period. In the present study, children's storytelling in different situational contexts was analyzed and evaluated: with a picture book without any text, after listening to a text from a picture book, and after a suggested story beginning (ie., with the introductory sentence given to them. The sample included children of three age groups, approximately 4, 6 and 8 years; each age group had approximately the same numbers of boys and girls. A total of over 300 stories were collected, which were subsequently analyzed and evaluated using a set of story developmental level criteria. Two key criteria were used: story coherence and cohesion. Comparisons by age and gender, as well as by context of storytelling, show significant developmental differences in story content and structure for different age groups, and the important role of storytelling context. Differences in storytelling between boys and girls did not prove statistically significant. The findings also suggest new options and approaches for further stimulations of speech development within preschool and primary school curricula might be considered.

Antifolate drug resistance: Novel mutations and haplotype ...

Indian Academy of Sciences (India)

N P Sarmah

2017-09-27

Sep 27, 2017 ... distribution in dhps and dhfr from Northeast India ... The findings of this study strongly discourage the use SP as a partner drug in ACT. ... led to critical hindrances in controlling of Plasmodium fal- ciparum (Pf) malaria in this part of India. ..... alignment editor and analysis programme for Windows95/98/. NT.

76 FR 72686 - 36(b)(1) Arms Sales Notification

Science.gov (United States)

2011-11-25

... DEPARTMENT OF DEFENSE Office of the Secretary [Transmittal Nos. 11-47] 36(b)(1) Arms Sales... Department of Defense is publishing the unclassified text of a section 36(b)(1) arms sales notification. This..., if any: FMS Case FAL-$73M-6Apr11 (vi) Sales Commission, Fee, etc., Paid, Offered, or Agreed To Be...

Relationship of plasma level of NT- ProBNP with development of AF in CABG patients

Directory of Open Access Journals (Sweden)

Tanaray B

2010-10-01

Full Text Available "nBackground: Studies of the association between post operative AF and Plasma level of NT- Pro BNP have reported conflicting findings. The aim of the present study was evaluation of the association between post coronary bypass graft- Atrial Fibrillation (AF and Plasma level of NT- ProBNP as an independent risk factor of AF development in patients undergoing coronary artery bypass graft."n "nMethods: In a cohort study, 79 patients with sinus rhythm who admitted in Imam Khomeini Hospital in Tehran, Iran, during February 2009 and February 2010 for CABG are included the study and followed for developing post operative AF rhythm."n "nResults: Post operative AF was found in 17.7% of patients. The peak time from the operation to the first AF episode was in second post op day in ten patients (71.4%. The serum level of ProBNP in patients with AF was significantly higher (1624± 647 versus 221± 238 pg/ml, p< 0/0001. Increased age, Increased LA size and high plasma level of ProBNP were associated with increased risk for post op AF. After adjustment of risk factors, plasma level of ProBNP was the most important risk factor with odds ratio of 15.34 with CI 95% 1.77-132.95 and then LA diameter with odds ratio of 6.11 with CI 95% 0.99-37.42 was independently correlated with post op AF. Correlation between plasma level of ProBNP with age and LA size was seen too (LA size r = 0.0281, p= 0.012. Between age and ProBNP (r= 0.337, p= 0.002. The best cut off point for plasma ProBNP as a predictor of post op AF was 854 pg/ml."n "nConclusion: Increased level of preoperative ProBNP levels could be an independent predictor of post operative Atrial Fibrillation.

Reducing failures rate within the project documentation using Building Information Modelling, especially Level of Development

Directory of Open Access Journals (Sweden)

Prušková Kristýna

2018-01-01

Full Text Available Paper´s focus is on differences between traditional modelling in 2D software and modelling within the BIM technology. Research uncovers failures connected to the traditional way of designing and construction of project documentation. There are revealed and shown mismatches within the project documentation. Solution within the Building information modelling Technology is outlined. As a reference, there is used experience with design of specific building in both ways of construction of project documentation: in the way of traditional modelling and in the way when using BIM technology, especially using Level of Development. Output of this paper is pointing to benefits of using advanced technology in building design, thus Building Information Modelling, especially Level of Development, which leads to reducing failures rate within the project documentation.

Sustainable Development and High Level Waste

Energy Technology Data Exchange (ETDEWEB)

Jensen, Mikael [Swedish Radiation Protection Inst., Stockholm (Sweden)

2001-07-01

Sustainable development, defined by the BrundtIand Commission as 'development that meets the needs of the present without compromising the ability of future generations to meet their own needs', relates to a number of issues such as population, health, food, species and ecosystems, energy, industrial development, urbanization, societal issues and economy, and how these global challenges could be met within a long term strategy. It is not obvious how the principle may be applied to final disposal of radioactive waste, but the global scope of the principle suggests that no sector in society should be exempted from scrutinizing its practices in the light of the challenge presented by sustainable development. Waste management, as pointed out by the International Commission on Radiological Protection, ICRP, cannot be seen as a free standing practice in need of its own justification. The produced waste cannot be seen separately from the other components of nuclear production. However, the existence of very long-lived radioactive nuclei in the spent fuel warrants a careful examination of this subpractice. Health based post-closure criteria or standards for long-lived waste, usually make use of the concept of partitioning dose limit. ICRP recommends that individuals in the public do not receive a yearly dose in excess of 1 mSv as a result of releases in connection with activities involving the use of ionising radiation, and that any single facility does not generate a dose burden to individuals in excess of a fraction of this value. For an operating facility, this fraction is normally at least a factor of three. By definition, operational changes are not possible for a closed repository. It follows from this that the partitioning has another function. One interpretation is that it can allow for the simultaneous use and burdens of future generation's activities. Both the Swedish and the proposed US criteria and from EPA and NRC, as well as standards from

Sustainable Development and High Level Waste

International Nuclear Information System (INIS)

Jensen, Mikael

2001-01-01

Sustainable development, defined by the BrundtIand Commission as 'development that meets the needs of the present without compromising the ability of future generations to meet their own needs', relates to a number of issues such as population, health, food, species and ecosystems, energy, industrial development, urbanization, societal issues and economy, and how these global challenges could be met within a long term strategy. It is not obvious how the principle may be applied to final disposal of radioactive waste, but the global scope of the principle suggests that no sector in society should be exempted from scrutinizing its practices in the light of the challenge presented by sustainable development. Waste management, as pointed out by the International Commission on Radiological Protection, ICRP, cannot be seen as a free standing practice in need of its own justification. The produced waste cannot be seen separately from the other components of nuclear production. However, the existence of very long-lived radioactive nuclei in the spent fuel warrants a careful examination of this subpractice. Health based post-closure criteria or standards for long-lived waste, usually make use of the concept of partitioning dose limit. ICRP recommends that individuals in the public do not receive a yearly dose in excess of 1 mSv as a result of releases in connection with activities involving the use of ionising radiation, and that any single facility does not generate a dose burden to individuals in excess of a fraction of this value. For an operating facility, this fraction is normally at least a factor of three. By definition, operational changes are not possible for a closed repository. It follows from this that the partitioning has another function. One interpretation is that it can allow for the simultaneous use and burdens of future generation's activities. Both the Swedish and the proposed US criteria and from EPA and NRC, as well as standards from Canada, UK and

Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.

Directory of Open Access Journals (Sweden)

Jamie Rae Acosta

Full Text Available FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS, a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-type or fALS (R521C human FUS. Cell cultures were made from these zebrafish and the subcellular localization of human FUS and the generation of stress granule (SG inclusions examined in different cell types, including differentiated motor neurons. We demonstrate that mutant FUS is mislocalized from the nucleus to the cytosol to a similar extent in motor neurons and all other cell types. Both wild-type and R521C FUS localized to SGs in zebrafish cells, demonstrating an intrinsic ability of human FUS to accumulate in SGs irrespective of the presence of disease-associated mutations or specific cell type. However, elevation in relative cytosolic to nuclear FUS by the R521C mutation led to a significant increase in SG assembly and persistence within a sub population of vulnerable cells, although these cells were not selectively motor neurons.

Single Pot Selective Hydrogenation of Furfural to 2-Methylfuran Over Carbon Supported Iridium Catalysts

KAUST Repository

Date, Nandan S; Hengne, Amol Mahalingappa; Huang, Kuo-Wei; Chikate, Rajeev C.; Rode, C. V.

2018-01-01

Various iridium supported carbon catalysts were prepared and screened for direct hydrogenation of furfural (FFR) to 2-methyl furan (2-MF). Amongest these, 5% Ir/C showed excellent results with complete FFR conversion and highest selectivity of 95% to 2-MF at very low H2 pressure of 100 psig. Metallic (Iro) and oxide ( IrO2) phases of Ir catalyzed first step hydrogenation involving FFR to FAL and subsequent hydrogenation to 2-MF,respecively. This was confirmed by XPS analysis and some controlled experiments. At low temperature of 140 oC, almost equal selectivities of FAL (42%) and 2-MF (43%) were observed, while higher temperature (220oC) favored selective hydrodeoxygenation. At optimized temperature, 2-MF formed selectively while higher pressure and higher catalyst loading favored ring hydrogenation of furfural rather than side chain hydrogenation. With combination of several control experimental results and detailed catalyst characterization, a plausible reaction pathway has been proposed for selective formation of 2-MF. The selectivity to various other products in FFR hydrogenation can be manipulated by tailoring the reaction conditions over the same catalyst.

Single Pot Selective Hydrogenation of Furfural to 2-Methylfuran Over Carbon Supported Iridium Catalysts

KAUST Repository

Date, Nandan S

2018-03-20

Various iridium supported carbon catalysts were prepared and screened for direct hydrogenation of furfural (FFR) to 2-methyl furan (2-MF). Amongest these, 5% Ir/C showed excellent results with complete FFR conversion and highest selectivity of 95% to 2-MF at very low H2 pressure of 100 psig. Metallic (Iro) and oxide ( IrO2) phases of Ir catalyzed first step hydrogenation involving FFR to FAL and subsequent hydrogenation to 2-MF,respecively. This was confirmed by XPS analysis and some controlled experiments. At low temperature of 140 oC, almost equal selectivities of FAL (42%) and 2-MF (43%) were observed, while higher temperature (220oC) favored selective hydrodeoxygenation. At optimized temperature, 2-MF formed selectively while higher pressure and higher catalyst loading favored ring hydrogenation of furfural rather than side chain hydrogenation. With combination of several control experimental results and detailed catalyst characterization, a plausible reaction pathway has been proposed for selective formation of 2-MF. The selectivity to various other products in FFR hydrogenation can be manipulated by tailoring the reaction conditions over the same catalyst.

Projected contributions of future wind farm development to community noise and annoyance levels in Ontario, Canada

International Nuclear Information System (INIS)

Whitfield Aslund, Melissa L.; Ollson, Christopher A.; Knopper, Loren D.

2013-01-01

Wind turbines produce sound during their operation; therefore, jurisdictions around the world have developed regulations regarding the placement of electricity generating wind farms with the intent of preventing unacceptable levels of ‘community noise’ in their vicinity. However, as survey results indicate that the relationship between wind turbine noise and annoyance may differ from noise-annoyance relationships for other common noise sources (e.g., rail, traffic), there are concerns that the application of general noise guidelines for wind turbines may lead to unacceptably high levels of annoyance in communities. In this study, previously published survey results that quantified wind turbine noise and self-reported annoyance were applied to the predicted noise levels (from turbines and transformers) for over 8000 receptors in the vicinity of 13 planned wind power developments in the province of Ontario, Canada. The results of this analysis indicate that the current wind turbine noise restrictions in Ontario will limit community exposure to wind turbine related noise such that levels of annoyance are unlikely to exceed previously established background levels of noise-related annoyance from other common noise sources. This provides valuable context that should be considered by policy-makers when evaluating the potential impacts of wind turbine noise on the community. -- highlights: •Wind turbine noise-annoyance relationship used to predict annoyance in Ontario. •Noise annoyance predicted to be <8% for non-participants <1 km from turbines. •Predicted levels of wind turbine noise annoyance similar to that from traffic noise. •Wind turbine noise annoyance not expected to exceed existing background levels

Influence of the Level of the Development of Skills on Labour Potential, its Implementation and Choice of Work Position

Directory of Open Access Journals (Sweden)

Kseniya Aleksandrovna Ustinova

2016-09-01

Full Text Available The article deals with the sociological assessment of the skills level and identification of its influence on some aspects of labour activity: the realization of labour potential, choice of the scope of activity, position and occupation. It suggests an approach based on the subjective evaluation of the population as an instrument of the skills level assessment. The received results are compared with the indirect estimates allowing to characterize some particular components of labour potential which are similar to the considered skills. A specific feature of the research is not only the determination of the professional sphere, occupation and position on the skills level, but also the accounting of the reverse effect. The methodological tools including the methods for the assessment of skills level, labour potential and extent of its implementation in a labour activity have been approved in the Vologda region. The study revealed that, at the present time, the most developed skills are the teamwork, communication and mutual understanding while the least developed ones are the initiative and creativity as well as ability to be retrained and readiness to increase the professional level. It shows that the employees of socially oriented spheres and also the representatives of state structures have more developed skills. At the same time, the development of innovative skills not only leads to the growth of labour potential, but also creates conditions for the employment in workplaces with higher skills requirements. The paper shows that higher skills level along with higher skills requirements leads to more complete implementation of cumulative potential in the labour activity. The received results can be used by regional authorities for the development of the analytical system of labour market, the development of labour force and the labour potential of the population.

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10.

Directory of Open Access Journals (Sweden)

Jacopo Lucchetti

Full Text Available Oxidative stress and mitochondrial impairment are the main pathogenic mechanisms of Amyotrophic Lateral Sclerosis (ALS, a severe neurodegenerative disease still lacking of effective therapy. Recently, the coenzyme-Q (CoQ complex, a key component of mitochondrial function and redox-state modulator, has raised interest for ALS treatment. However, while the oxidized form ubiquinone10 was ineffective in ALS patients and modestly effective in mouse models of ALS, no evidence was reported on the effect of the reduced form ubiquinol10, which has better bioavailability and antioxidant properties. In this study we compared the effects of ubiquinone10 and a new stabilized formulation of ubiquinol10 on the disease course of SOD1(G93A transgenic mice, an experimental model of fALS. Chronic treatments (800 mg/kg/day orally started from the onset of disease until death, to mimic the clinical trials that only include patients with definite ALS symptoms. Although the plasma levels of CoQ10 were significantly increased by both treatments (from <0.20 to 3.0-3.4 µg/mL, no effect was found on the disease progression and survival of SOD1(G93A mice. The levels of CoQ10 in the brain and spinal cord of ubiquinone10- or ubiquinol10-treated mice were only slightly higher (≤10% than the endogenous levels in vehicle-treated mice, indicating poor CNS availability after oral dosing and possibly explaining the lack of pharmacological effects. To further examine this issue, we measured the oxidized and reduced forms of CoQ9/10 in the plasma, brain and spinal cord of symptomatic SOD1(G93A mice, in comparison with age-matched SOD1(WT. Levels of ubiquinol9/10, but not ubiquinone9/10, were significantly higher in the CNS, but not in plasma, of SOD1(G93A mice, suggesting that CoQ redox system might participate in the mechanisms trying to counteract the pathology progression. Therefore, the very low increases of CoQ10 induced by oral treatments in CNS might be not sufficient to

Mapping and navigating transitions - The multi-level perspective compared with arenas of development

DEFF Research Database (Denmark)

Jørgensen, Ulrik

2012-01-01

actors to navigate. The second concern builds on the observation that actors engage at all levels in society including visions, institutions, and innovations. The third concern addresses the role of academic theories and advice regarding governance of transition processes in which they function......Transitions of socio-technical systems imply the reconfiguration of institutions and politics making made evident the need to understand and intervene in existing patterns of growth and socio-technical practices in more sustainable directions. In recent decades, theories of transitions have been...... introduced, which include the multi-level approach indicating ways to govern transitions through understanding the interactions between niches, regimes and landscapes. An alternative approach is suggested, which takes its outset in arenas of development and increased awareness of actors and their way...

Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels

International Nuclear Information System (INIS)

Shankaran, Harish; Adeshina, Femi; Teeguarden, Justin G.

2013-01-01

Provisional Advisory Levels (PALs) are tiered exposure limits for toxic chemicals in air and drinking water that are developed to assist in emergency responses. Physiologically-based pharmacokinetic (PBPK) modeling can support this process by enabling extrapolations across doses, and exposure routes, thereby addressing gaps in the available toxicity data. Here, we describe the development of a PBPK model for Fentanyl – a synthetic opioid used clinically for pain management – to support the establishment of PALs. Starting from an existing model for intravenous Fentanyl, we first optimized distribution and clearance parameters using several additional IV datasets. We then calibrated the model using pharmacokinetic data for various formulations, and determined the absorbed fraction, F, and time taken for the absorbed amount to reach 90% of its final value, t90. For aerosolized pulmonary Fentanyl, F = 1 and t90 50 human datasets. • Model predictions are in good agreement with the available pharmacokinetic data. • The model can be used for extrapolating across routes, doses and exposure durations. • We illustrate how the model can be used for developing Provisional Advisory Levels

Research on the improvement of nuclear safety -Development of computing code system for level 3 PSA

Energy Technology Data Exchange (ETDEWEB)

Jeong, Jong Tae; Kim, Dong Ha; Park, Won Seok; Hwang, Mi Jeong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1995-07-01

Among the various research areas of the level 3 PSA, the effect of terrain on the transport of radioactive material was investigated. These results will give a physical insight in the development of a new dispersion model. A wind tunnel experiment with bell shaped hill model was made in order to develop a new dispersion model. And an improved dispersion model was developed based on the concentration distribution data obtained from the wind tunnel experiment. This model will be added as an option to the atmospheric dispersion code. A stand-alone atmospheric code using MS Visual Basic programming language which runs at the Windows environment of a PC was developed. A user can easily select a necessary data file and type input data by clicking menus, and can select calculation options such building wake, plume rise etc., if necessary. And a user can easily understand the meaning of concentration distribution on the map around the plant site as well as output files. Also the methodologies for the estimation of radiation exposure and for the calculation of risks was established. These methodologies will be used for the development of modules for the radiation exposure and risks respectively. These modules will be developed independently and finally will be combined to the atmospheric dispersion code in order to develop a level 3 PSA code. 30 tabs., 56 figs., refs. (Author).

Research on the improvement of nuclear safety -Development of computing code system for level 3 PSA

International Nuclear Information System (INIS)

Jeong, Jong Tae; Kim, Dong Ha; Park, Won Seok; Hwang, Mi Jeong

1995-07-01

Among the various research areas of the level 3 PSA, the effect of terrain on the transport of radioactive material was investigated. These results will give a physical insight in the development of a new dispersion model. A wind tunnel experiment with bell shaped hill model was made in order to develop a new dispersion model. And an improved dispersion model was developed based on the concentration distribution data obtained from the wind tunnel experiment. This model will be added as an option to the atmospheric dispersion code. A stand-alone atmospheric code using MS Visual Basic programming language which runs at the Windows environment of a PC was developed. A user can easily select a necessary data file and type input data by clicking menus, and can select calculation options such building wake, plume rise etc., if necessary. And a user can easily understand the meaning of concentration distribution on the map around the plant site as well as output files. Also the methodologies for the estimation of radiation exposure and for the calculation of risks was established. These methodologies will be used for the development of modules for the radiation exposure and risks respectively. These modules will be developed independently and finally will be combined to the atmospheric dispersion code in order to develop a level 3 PSA code. 30 tabs., 56 figs., refs. (Author)

Development of acute exposure guideline levels for airborne exposures to hazardous substances.

Science.gov (United States)

Krewski, Daniel; Bakshi, Kulbir; Garrett, Roger; Falke, Ernest; Rusch, George; Gaylor, David

2004-04-01

Hazardous substances can be released into the atmosphere due to industrial and transportation accidents, fires, tornadoes, earthquakes, and terrorists, thereby exposing workers and the nearby public to potential adverse health effects. Various enforceable guidelines have been set by regulatory agencies for worker and ambient air quality. However, these exposure levels generally are not applicable to rare lifetime acute exposures, which possibly could occur at high concentrations. Acute exposure guideline levels (AEGLs) provide estimates of concentrations for airborne exposures for an array of short durations that possibly could cause mild (AEGL-1), severe, irreversible, potentially disabling adverse health effects (AEGL-2), or life threatening effects (AEGL-3). These levels can be useful for emergency responders and planners in reducing or eliminating potential risks to the public. Procedures and methodologies for deriving AEGLs are reviewed in this paper that have been developed in the United States, with direct input from international representatives of OECD member-countries, by the National Advisory Committee for Acute Exposure Guidelines for Hazardous Substances and reviewed by the National Research Council. Techniques are discussed for the extrapolation of effects across different exposure durations. AEGLs provide a viable approach for assisting in the prevention, planning, and response to acute airborne exposures to toxic agents.

Revised Uniform Summary of Surface Weather Observations (RUSSWO) Misawa AB, Japan

Science.gov (United States)

1980-07-03

CODES DIST AVAIL AND/OR SPECIAL DATE ACCESSIONED DISTRIBUTION STAMP DATE RECEIVED IN DTIC PHOTOGRAPH THIS SHEET AND RETURN TO DTIC-DDA-2 FORM DOCUMENT...UOOIM.S FORM AM )W Ii. ’I - GLUdFAL CLIvlsTOLO0Y BRANCH ,SE V f-A’ CEILING VERSUS VISIBILITYiAIA ,,.,Te .. SEF-VICI/MAC ~ ’ ISAIA AS JP

Relation among the level of development of the competences in the managers of the health services and the institutional quality, Antioquia, 2005

Directory of Open Access Journals (Sweden)

Libardo A. Giraldo G

2008-06-01

Full Text Available Objective: to determine the relationship between the level of development of the competences of the managers of health services in Antioquia as well as the quality of the institution they conduct. Methodology: a probabilistic stratified random sampling by level of complexity was done and then a simple random sampling in each one. 112 managers constituted the sample. Four instruments were used; three of them to evaluate the competence level of the managers and the other one to evaluate the level of institutional quality. Results: the development of the competences among managers was found between the basic and inexperienced levels, showing a poor performance in their management tasks. Additionally, a high correlation among competences was also identified indicating that the high or low level of development of a competence directly affects the performance of the manager. The quality of the institutions showed levels of business development between incipient and medium, thus revealing some sort of functional units which are determinant in the business development, such as service operations, planning, management control, and marketing. Finally, it was shown that the presence of some competences in the manager positively impacts the development of the functional units. Thus the performance of managers has direct effects on the success or failure of the institution.

Development of anodic stripping voltametry for the determination of palladium in high level nuclear waste

Energy Technology Data Exchange (ETDEWEB)

Bhardwaj, T. K. [North Carolina State University, Raleigh (United States); Sharma, H. S.; Affarwal, S. K. [Bhabha Atomic Research Centre, Mumbai (India); Jain, P. C. [Meerut College, Meerut (India)

2012-12-15

Deposition potential, deposition time, square wave frequency, rotation speed of the rotating disc electrode, and palladium concentration were studied on a Glassy Carbon Electrode (GCE) in 0.01M HCl for the determination of palladium in High Level Nuclear Waste (HLNW) by anodic stripping voltammetry. Experimental conditions were optimized for the determination of palladium at two different, 10-8 and 10-7 M, levels. Error and standard deviation of this method were under 1% for all palladium standard solutions. The developed technique was successfully applied as a subsidiary method for the determination of palladium in simulated high level nuclear waste with very good precision and high accuracy (under 1 % error and standard deviation).

Low-level radioactive waste from commercial nuclear reactors. Volume 1. Recommendations for technology developments with potential to significantly improve low-level radioactive waste management

International Nuclear Information System (INIS)

Rodgers, B.R.; Jolley, R.L.

1986-02-01

The overall task of this program was to provide an assessment of currently available technology for treating commercial low-level radioactive waste (LLRW), to initiate development of a methodology for choosing one technology for a given application, and to identify research needed to improve current treatment techniques and decision methodology. The resulting report is issued in four volumes. Volume 1 provides an executive summary and a general introduction to the four-volume set, in addition to recommendations for research and development (R and D) for low-level radioactive waste (LLRW) treatment. Generic, long-range, and/or high-risk programs identified and prioritized as needed R and D in the LLRW field include: (1) systems analysis to develop decision methodology; (2) alternative processes for dismantling, decontaminating, and decommissioning; (3) ion exchange; (4) incinerator technology; (5) disposal technology; (6) demonstration of advanced technologies; (7) technical assistance; (8) below regulatory concern materials; (9) mechanical treatment techniques; (10) monitoring and analysis procedures; (11) radical process improvements; (12) physical, chemical, thermal, and biological processes; (13) fundamental chemistry; (14) interim storage; (15) modeling; and (16) information transfer. The several areas are discussed in detail

Motivation of the personnal as the level of innovative development of the agricultural enterprises

OpenAIRE

EVCHUK L.; BRILYAKOVA E.

2011-01-01

The motivation of the personnel acts as the strong lever of innovative development of the agricultural enterprises. The reasons of inefficiency of the mechanism of motivation in agriculture are opened in article. It is proved that appropriate level of wages and social arrangement of rural territories should underlie the effective mechanism of motivation.

Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction Efeitos da administração de albumina nos níveis séricos de enzimas hepáticas em ratos com obstrução biliar extra-hepática

Directory of Open Access Journals (Sweden)

Jorge Fernando Rebouças Lessa

2011-01-01

Full Text Available PURPOSE: To study the influence of albumin on changes of liver function in the extrahepatic biliary obstruction through an experimental model in rats. METHODS: Sixty rats were divided into four groups: Group C (Control: 6 animals. Group M (Fictitious Operation: 18 rats underwent laparotomy and handling of the bile ducts; Groups O (extrahepatic biliary obstruction and A (Treated with 2% albumin: 18 animals in each group underwent ligation of the ductus liver; The animals in groups M, O and A were divided into three subgroups of 6 animals each to be killed in the 7, 14 and 21 days postoperative (POD. Blood was drawn for determination of total bilirubin (TB, indirect bilirubin (IB, direct bilirubin (DB, alkaline phosphatase (ALP, aspartate aminotransferase (AST and alanine aminotransferase (ALT. RESULTS: On POD 7, BI levels were 4.5 mg / dl in group O and 2.1 mg / dl in group A (p = 0.025. On the 14th POD, the levels of PA were 1185.2 U / l in the group and O 458.3 U / l in group A (p = 0.004. ALT levels were 101.7 U / l in the group O and 75.7 U / l in group A (= 0.037. On POD 21, the levels of ALP were 1069.5 U / l in the group O and 468.3 U / l in group A (p = 0, 004. CONCLUSION: The administration of albumin reduced the serum levels of bilirubin in the 7th day of supplementationOBJETIVO: Estudar a influência da albumina em alterações funcionais do fígado na obstrução biliar extra-hepática por meio de um modelo experimental desenvolvido em ratos. MÉTODOS: 60 ratos distribuídos em quatro grupos: Grupo C (Controle: 6 animais. Grupo M (Operação Fictícia: 18 ratos submetidos à laparotomia e manuseio das vias biliares; Grupos O (Obstrução Biliar Extra-hepática e A (Tratados com albumina a 2%: 18 animais, em cada grupo, submetidos à ligadura do ducto hepático; Os animais dos grupos M, O e A foram distribuídos em três subgrupos de 6 animais cada, para serem mortos nos 7°, 14° e 21° dias pós- operatórios (DPO. Foi colhido sangue

Development of the ATLAS High-Level Trigger Steering and Inclusive Searches for Supersymmetry

CERN Document Server

Eifert, T

2009-01-01

The presented thesis is divided into two distinct parts. The subject of the first part is the ATLAS high-level trigger (HLT), in particular the development of the HLT Steering, and the trigger user-interface. The second part presents a study of inclusive supersymmetry searches, including a novel background estimation method for the relevant Standard Model (SM) processes. The trigger system of the ATLAS experiment at the Large Hadron Collider (LHC) performs the on-line physics selection in three stages: level-1 (LVL1), level-2 (LVL2), and the event filter (EF). LVL2 and EF together form the HLT. The HLT receives events containing detector data from high-energy proton (or heavy ion) collisions, which pass the LVL1 selection at a maximum rate of 75 kHz. It must reduce this rate to ~200 Hz, while retaining the most interesting physics. The HLT is a software trigger and runs on a large computing farm. At the heart of the HLT is the Steering software. The HLT Steering must reach a decision whether or not to accept ...

Developing micro-level urban ecosystem indicators for sustainability assessment

International Nuclear Information System (INIS)

Dizdaroglu, Didem

2015-01-01

Sustainability assessment is increasingly being viewed as an important tool to aid in the shift towards sustainable urban ecosystems. An urban ecosystem is a dynamic system and requires regular monitoring and assessment through a set of relevant indicators. An indicator is a parameter which provides information about the state of the environment by producing a quantitative value. Indicator-based sustainability assessment needs to be considered on all spatial scales to provide efficient information of urban ecosystem sustainability. The detailed data is necessary to assess environmental change in urban ecosystems at local scale and easily transfer this information to the national and global scales. This paper proposes a set of key micro-level urban ecosystem indicators for monitoring the sustainability of residential developments. The proposed indicator framework measures the sustainability performance of urban ecosystem in 3 main categories including: natural environment, built environment, and socio-economic environment which are made up of 9 sub-categories, consisting of 23 indicators. This paper also describes theoretical foundations for the selection of each indicator with reference to the literature [tr

Effects of reactive oxygen species levels in prepared culture media on embryo development: a comparison of two media.

Science.gov (United States)

Shih, Ying-Fu; Lee, Tsung-Hsien; Liu, Chung-Hsien; Tsao, Hui-Mei; Huang, Chun-Chia; Lee, Maw-Sheng

2014-12-01

This study determined the correlation between the levels of reactive oxygen species (ROS) in prepared culture media and the early development of human embryos. This was an autocontrolled comparison study. A total of 159 patients undergoing in vitro fertilization/intracytoplasmic sperm injection treatment were recruited in this study. The pH values, osmolarity pressures, and ROS levels of 15 batches of two culture media were measured. Sibling oocytes or embryos from individual patients were randomly assigned to two culture groups with Quinn's Advantage Cleavage and Blastocyst media (QAC/QAB) or GIII series cleavage and blastocyst media (G1.3/G2.3). The difference between the two culture groups was analyzed using one-sample t test. The QAC/QAB and G1.3/G2.3 media exhibited similar pH values and osmolarity pressures. However, the prepared QAC/QAB media were characterized to contain lower amounts of ROS than the G1.3/G2.3 media. Furthermore, the blastocysts that developed under the QAC/QAB media were morphologically superior to those that developed under the G1.3/G2.3 media. The elevated ROS levels in culture media were associated with poor development of blastocyst-stage embryos. Measurement of ROS levels may be a valuable process for medium selection or modification. Copyright © 2014. Published by Elsevier B.V.

Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels

Energy Technology Data Exchange (ETDEWEB)

Shankaran, Harish, E-mail: harish.shankaran@pnnl.gov [Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352 (United States); Adeshina, Femi [National Homeland Security Research Center, United States Environmental Protection Agency, Washington, DC 20460 (United States); Teeguarden, Justin G. [Systems Toxicology Group, Pacific Northwest National Laboratory, Richland, WA 99352 (United States)

2013-12-15

Provisional Advisory Levels (PALs) are tiered exposure limits for toxic chemicals in air and drinking water that are developed to assist in emergency responses. Physiologically-based pharmacokinetic (PBPK) modeling can support this process by enabling extrapolations across doses, and exposure routes, thereby addressing gaps in the available toxicity data. Here, we describe the development of a PBPK model for Fentanyl – a synthetic opioid used clinically for pain management – to support the establishment of PALs. Starting from an existing model for intravenous Fentanyl, we first optimized distribution and clearance parameters using several additional IV datasets. We then calibrated the model using pharmacokinetic data for various formulations, and determined the absorbed fraction, F, and time taken for the absorbed amount to reach 90% of its final value, t90. For aerosolized pulmonary Fentanyl, F = 1 and t90 < 1 min indicating complete and rapid absorption. The F value ranged from 0.35 to 0.74 for oral and various transmucosal routes. Oral Fentanyl was absorbed the slowest (t90 ∼ 300 min); the absorption of intranasal Fentanyl was relatively rapid (t90 ∼ 20–40 min); and the various oral transmucosal routes had intermediate absorption rates (t90 ∼ 160–300 min). Based on these results, for inhalation exposures, we assumed that all of the Fentanyl inhaled from the air during each breath directly, and instantaneously enters the arterial circulation. We present model predictions of Fentanyl blood concentrations in oral and inhalation scenarios relevant for PAL development, and provide an analytical expression that can be used to extrapolate between oral and inhalation routes for the derivation of PALs. - Highlights: • We develop a Fentanyl PBPK model for relating external dose to internal levels. • We calibrate the model to oral and inhalation exposures using > 50 human datasets. • Model predictions are in good agreement with the available

LONG TERM STABILITY STUDY AT FNAL AND SLAC USING BINP DEVELOPED HYDROSTATIC LEVEL SYSTEM

Energy Technology Data Exchange (ETDEWEB)

Seryi, Andrei

2003-05-28

Long term ground stability is essential for achieving the performance goals of the Next Linear Collider. To characterize ground motion on relevant time scales, measurements have been performed at three geologically different locations using a hydrostatic level system developed specifically for these studies. Comparative results from the different sites are presented in this paper.

Relationship of Bilirubin Levels in Infancy to Later Intellectual Development. Interim Report No. 20.

Science.gov (United States)

Rubin, Rosalyn A.; And Others

The relationship of bilirubin (a red bile pigment that is sometimes found in the urine and occurs in the blood and tissues in jaundice) in infancy to later intellectual development was investigated in 241 infants with moderately elevated and high bilirubin levels. Ss were administered motor, psycholinguistic, and intelligence tests at age 8…

Measuring the Level of Industrial Green Development and Exploring Its Influencing Factors: Empirical Evidence from China’s 30 Provinces

Directory of Open Access Journals (Sweden)

Chaofan Chen

2016-02-01

Full Text Available Nowadays, with the green economy becoming mainstream in the world, an industrial revolution as the core of green development has emerged. Based on the empirical evidence from China’s 30 provinces, this study establishes an evaluation index system of China’s industrial green development and applies the analytic hierarchy process to determine the indices’ weights and properties to measure the level of industrial green development in China’s 30 provinces. Then, an empirical study is conducted to explore the relevant factors influencing China’s industrial green development by using the dynamic panel data model and a panel threshold test. The results show that China’s level of industrial green development has the characteristic of typical regional differentiation with a ladder-like distribution from the east and middle to the west, and the eastern region has the highest level on industrial green output, industrial green efficiency and industrial green innovation. Technological progress and innovation can stimulate industrial green development. The impact of environmental regulation and foreign investment on industrial green development presents a nonlinear “N”-type trend, and the positive effects are mainly observed in eastern China. Capital deepening, heavy chemical industries and an unreasonable energy structure are not effective in industrial green development. There is no direct relation between the enterprise scale and industrial green development.

RELATIVE MPORTANCE OF PAY LEVEL SATISFACTION, CAREER DEVELOPMENT OPPORTUNITIES, AND SUPERVISOR SUPPORT IN PERCEIVED ORGANIZATIONAL SUPPORT

OpenAIRE

Hasnu, Muhammed WASEEM SAF

2010-01-01

This paper presents the relative impact of supervisor support, pay level satisfaction & career growth opportunities on the development of perceived organizational support (POS) of employees. Survey data were collected from banking sector professionals working in the branches of four major private commercial banks of Pakistan in Hazara Division. The findings of this study highlighted that “career growth opportunities” is a stronger predictor of POS than supervisor support and pay level...

Development of System Model for Level 1 Probabilistic Safety Assessment of TRIGA PUSPATI Reactor

International Nuclear Information System (INIS)

Tom, P.P; Mazleha Maskin; Ahmad Hassan Sallehudin Mohd Sarif; Faizal Mohamed; Mohd Fazli Zakaria; Shaharum Ramli; Muhamad Puad Abu

2014-01-01

Nuclear safety is a very big issue in the world. As a consequence of the accident at Fukushima, Japan, most of the reactors in the world have been reviewed their safety of the reactors including also research reactors. To develop Level 1 Probabilistic Safety Assessment (PSA) of TRIGA PUSPATI Reactor (RTP), three organizations are involved; Nuclear Malaysia, AELB and UKM. PSA methodology is a logical, deductive technique which specifies an undesired top event and uses fault trees and event trees to model the various parallel and sequential combinations of failures that might lead to an undesired event. Fault Trees (FT) methodology is use in developing of system models. At the lowest level, the Basic Events (BE) of the fault trees (components failure and human errors) are assigned probability distributions. In this study, Risk Spectrum software used to construct the fault trees and analyze the system models. The results of system models analysis such as core damage frequency (CDF), minimum cut set (MCS) and common cause failure (CCF) uses to support decision making for upgrading or modification of the RTP?s safety system. (author)

Identification of sites for the low-level waste disposal development and demonstration program

International Nuclear Information System (INIS)

Ketelle, R.H.; Lee, D.W.

1988-04-01

This report presents the results of site selection studies for potential low-level radioactive waste disposal sites on the Oak Ridge Reservation (ORR). Summaries of the site selection procedures used and results of previous site selection studies on the ORR are included. This report includes recommendations of sites for demonstration of shallow land burial using engineered trench designs and demonstration of above-grade disposal using design concepts similar to those used in tumulus disposal. The site selection study, like its predecessor (ORNL/TM-9717, Use of DOE Site Selection Criteria for Screening Low-Level Waste Disposal Sites on the Oak Ridge Reservation), involved application of exclusionary site screening criteria to the region of interest to eliminate unacceptable areas from consideration. Also like the previous study, the region of interest for this study was limited to the Oak Ridge Department of Energy Reservation. Reconnaissance-level environmental data were used in the study, and field inspections of candidate sites were made to verify the available reconnaissance data. Five candidate sites, all underlain by Knox dolomite residuum and bedrock, were identified for possible development of shallow land burial facilities. Of the five candidate sites, the West Chestnut site was judged to be best suited for deployment of the shallow land burial technology. Three candidate sites, all underlain by the Conasauga Group in Bear Creek Valley, were identified for possible development of above-grade disposal technologies. Of the three sites identified, the Central Bear Creek Valley site lying between State Route 95 and Gum Hollow Road was ranked most favorable for deployment of the above-grade disposal technology

Development of a fully-coupled, all atates, all hazards level 2 PSA at leibstadt nuclear power plant

Energy Technology Data Exchange (ETDEWEB)

Zvoncek, Pavol; Nusbaumer, Olivier [Safety Compliance and Technical Support Department, Leibstadt Nuclear Power Plant, Leibstadt (Sweden); Torri, Alfred [Risk Management Associates, Inc., Encinitas (United States)

2017-03-15

This paper describes the development process, the innovative techniques used and insights gained from the latest integrated, full scope, multistate Level 2 PSA analysis conducted at the Leibstadt Nuclear Power Plant (KKL), Switzerland. KKL is a modern single-unit General Electric Boiling Water Reactor (BWR/6) with Mark III Containment, and a power output of 3600MWth/1200MWe, the highest among the five operating reactors in Switzerland. A Level 2 Probabilistic Safety Assessment (PSA) analyses accident phenomena in nuclear power plants, identifies ways in which radioactive releases from plants can occur and estimates release pathways, magnitude and frequency. This paper attempts to give an overview of the advanced modeling techniques that have been developed and implemented for the recent KKL Level 2 PSA update, with the aim of systematizing the analysis and modeling processes, as well as complying with the relatively prescriptive Swiss requirements for PSA. The analysis provides significant insights into the absolute and relative importance of risk contributors and accident prevention and mitigation measures. Thanks to several newly developed techniques and an integrated approach, the KKL Level 2 PSA report exhibits a high degree of reviewability and maintainability, and transparently highlights the most important risk contributors to Large Early Release Frequency (LERF) with respect to initiating events, components, operator actions or seismic component failure probabilities (fragilities)

Vitamin E homologs and ¿-oryzanol levels in rice (Oryza sativa L.) during seed development

Science.gov (United States)

Vitamin E homologs (tocopherols and tocotrienols) and gamma-oryzanol have gained significant attention due to their proposed health benefits and ability to increase vegetable oil stability. Changes in the levels of these phytochemicals were examined during seed development. Rapid accumulation of toc...

Participation in development activities at the local level : case studies from a Sri Lankan village

NARCIS (Netherlands)

Frerks, G.E.

1991-01-01

This study is a sociological analysis of popular participation in local level development activities in Tegashena village in the Matara District, Sri Lanka. Social, economic, political and administrative factors that influence this process are identified.

The study discusses how the

Development of chemical profiles for U.S. Department of Energy low-level mixed wastes

International Nuclear Information System (INIS)

Wang, Y.Y.; Wilkins, B.D.; Meshkov, N.K.; Dolak, D.A.

1995-01-01

Chemical and radiological profiles of waste streams from US Department of Energy (DOE) low-level mixed wastes (LLMWs) have been developed by Argonne National Laboratory (ANL) to provide technical support information for evaluating waste management alternatives in the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS). The chemical profiles were developed for LLMW generated from both Waste Management (WM) operations and from Environmental Restoration (ER) activities at DOE facilities. Information summarized in the 1994 DOE Mixed Waste Inventory Report (MWIR-2), the Pacific Northwest Laboratory (PNL) Automated Remedial Assessment Methodology (ARAM), and associated PNL supporting data on ER secondary waste streams that will be treated in WM treatment facilities were used as the sources for developing chemical profiles. The methodology for developing the LLMW chemical profiles is discussed, and the chemical profiles developed from data for contact-handled (CH) non-alpha LLMW are presented in this paper. The hazardous chemical composition of remote-handled (RH) LLMW and alpha LLMW follow the chemical profiles developed for CH non-alpha LLMW

Load leveling air conditioning technology development by unused energy high-level utilization. Summary of achievements by development themes; Miriyo energy kodo katsuyo fuka heijunka reidanbo gijutsu kaihatsu. Kaihatsu temabetsu seika gaiyo

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-01-01

This paper introduces a number of research and development cases on utilization of unutilized energies. In developing the component technology for a thermal plant utilizing low-temperature unutilized energies, the paper introduces a heat exchanger system to collect heat from sea water, a heat exchanger system to collect heat from waste heated area in subways and urban sewage plants, and a high-density heat transportation system using ice plus water slurry or PCM-C plus water slurry. Furthermore, with regard to the heat pump system using low-temperature unutilized hear sources, development was introduced on a 'heat source load responsive heat pump system', which combines a load variation responsive heat pump utilizing river waters with a latent heat storage system using nighttime electric power serving for electric power load leveling. In developing the component technology for a heat plant utilizing high-temperature unutilized energies, introduction was given on a turbine driven turbo type heat pump system, a high-efficiency absorption type heat pump, a waste heat driven absorption type freezer, and an urban type underground heat storage tank. (NEDO)

UNEARTHING GLOBAL FINANCIAL INCLUSION LEVELS AND ANALYSIS OF FINANCIAL INCLUSION AS A MEDIATING FACTOR IN GLOBAL HUMAN DEVELOPMENT

Directory of Open Access Journals (Sweden)

Roshny Unnikrishnan

2015-04-01

Full Text Available This study is a result of the author’s inquisition to unearth the current values of Global Financial Inclusion and its relationship with economic growth measured by Gross Domestic product(GDP and human development measured by United Nations Human Development Index (HDI. The Financial Inclusion (FI levels are measured using Index for Financial Inclusion .The relationship between GDP and HDI with FI as mediator, using multiple regression, is validated on a global level based on data of 162 countries for the year 2011. An overall global mediation analysis is undertaken to establish Financial Inclusion as a mediating factor and partial mediation on human development is validated. The study is valid and unique in the global context of income inequality prevailing in developed, developing and underdeveloped countries as it validates the argument that an impressive GDP performance does not ensure equity in economic growth.

Analysis of environmental issues related to small-scale hydroelectric development. III. Water level fluctuation

Energy Technology Data Exchange (ETDEWEB)

Hildebrand, S.G. (ed.)

1980-10-01

Potential environmental impacts in reservoirs and downstream river reaches below dams that may be caused by the water level fluctuation resulting from development and operation of small scale (under 25MW) hydroelectric projects are identified. The impacts discussed will be of potential concern at only those small-scale hydroelectric projects that are operated in a store and release (peaking) mode. Potential impacts on physical and chemical characteristics in reservoirs resulting from water level fluctuation include resuspension and redistribution of bank and bed sediment; leaching of soluble organic matter from sediment in the littoral zone; and changes in water quality resulting from changes in sediment and nutrient trap efficiency. Potential impacts on reservoir biota as a result of water level fluctuation include habitat destruction and the resulting partial or total loss of aquatic species; changes in habitat quality, which result in reduced standing crop and production of aquatic biota; and possible shifts in species diversity. The potential physical effects of water level fluctuation on downstream systems below dams are streambed and bank erosion and water quality problems related to resuspension and redistribution of these materials. Potential biological impacts of water level fluctuation on downstream systems below dams result from changes in current velocity, habitat reduction, and alteration in food supply. These alterations, either singly or in combination, can adversely affect aquatic populations below dams. The nature and potential significance of adverse impacts resulting from water level fluctuation are discussed. Recommendations for site-specific evaluation of water level fluctuation at small-scale hydroelectric projects are presented.

Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure.

Directory of Open Access Journals (Sweden)

Cristiane Miranda da Silva

Full Text Available Lung diseases constitute an important public health problem and its growing level of concern has led to efforts for the development of new therapies, particularly for the control of lung inflammation. Low Level Laser Therapy (LLLT has been highlighted as a non-invasive therapy with few side effects, but its mechanisms need to be better understood and explored. Considering that pollution causes several harmful effects on human health, including lung inflammation, in this study, we have used formaldehyde (FA, an environmental and occupational pollutant, for the induction of neutrophilic lung inflammation. Our objective was to investigate the local and systemic effects of LLLT after FA exposure. Male Wistar rats were exposed to FA (1% or vehicle (distillated water during 3 consecutive days and treated or not with LLLT (1 and 5 hours after each FA exposure. Non-manipulated rats were used as control. 24 h after the last FA exposure, we analyzed the local and systemic effects of LLLT. The treatment with LLLT reduced the development of neutrophilic lung inflammation induced by FA, as observed by the reduced number of leukocytes, mast cells degranulated, and a decreased myeloperoxidase activity in the lung. Moreover, LLLT also reduced the microvascular lung permeability in the parenchyma and the intrapulmonary bronchi. Alterations on the profile of inflammatory cytokines were evidenced by the reduced levels of IL-6 and TNF-α and the elevated levels of IL-10 in the lung. Together, our results showed that LLLT abolishes FA-induced neutrophilic lung inflammation by a reduction of the inflammatory cytokines and mast cell degranulation. This study may provide important information about the mechanisms of LLLT in lung inflammation induced by a pollutant.

Development of a low-level, in-line alpha counter (LLILAC)

International Nuclear Information System (INIS)

Gritzo, R.E.; Farnham, J.E.; Fowler, M.M.; Wouters, J.

1996-01-01

This is the final report of a two-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). With the increasing awareness of water contamination issues and the rising consequences of any form of contamination, real-time continuous monitoring is rapidly becoming a necessity. In particular, monitoring for the presence of any radioactive material is paramount. The most difficult of such monitoring tasks is that of detecting alpha-emitting radionuclides in water. Our development of the Low Level In-Line Alpha Counter (LLILAC) addresses the need for on-line, near real-time monitoring of alpha-emitting radionuclides in aqueous streams in a wide variety of applications. Although primarily designed as an on-line instrument for real-time applications, the detector can also be used for long-term in situ/post-closure monitoring. This detection system operates by allowing the stream to be monitored to come in contact with a large number of small rods or tubes made of scintillation material. By maximizing the surface to volume ratio of the scintillator, the response to alpha particles is favored over other types of radiation. Several configurations of scintillator and light collection schemes have been investigated to optimize the detection efficiency. We have also written several Monte Carlo codes to help to predict and understand the detector performance

The development of gate monitor for low level radioactive waste

International Nuclear Information System (INIS)

Fujisawa, Morio; Watanabe, Michito; Kato, Tatsuo

1994-01-01

Low-level radioactive waste (LLW) generated from nuclear power plants in Japan, have been deposited in the yard of each power plant. At present, it is stored in about 500,000 drum cans (200l each). These drum cans are carried to Mutsu-ogawara Port by special transport ships and then transferred to Rokkasho LLW transport trucks (special vehicles) for storage. The gate monitor is used to automatically measure the dose rate on the vehicles loaded with transport vessels from a remote location, to ensure the safe transportation from Mutsu-ogawara Port the Burying Center. It is a new system which has been developed for effective measurement of dose rate on a number of transport vessels in a short time. This system is the first in the world for measuring dose rate on vehicles. Such a system cannot be found in any country of the world. (author)

CRITERIA, PARAMETERS AND LEVELS OF DEVELOPING ACTIVITY COMPONENTS OF PRIMARY SCHOOL TEACHERS’ SOCIAL COMPETENCE IN THE SYSTEM OF POSTGRADUATE EDUCATION

Directory of Open Access Journals (Sweden)

Olena Varetska

2016-11-01

Full Text Available Only recently scientists have directed their search to development criterion-level system of diagnostic tool of competence of teachers, including social one. The complexity is connected with the lack of a clear pedagogic performance of evaluation system of training of primary school teachers in high education, the efficiency of their education in postgraduate course for the development of social competence and established methods (procedures of the development. Despite of the some issues elaborated on the content and structure of the measurement, diagnostic tools evaluation categorical apparatus only conventional scientific view on the question of definition of objective criteria, indicators and levels of social competence of the person are not made. The lack of a clear system of evaluation of the results of primary school teachers training in high education institutions, the effectiveness of social competence of primary school teachers in the system of postgraduate education, established methods lead to development of the appropriate criterion-level tools. According to the limits of the article it focuses on activity-component of social competence primary school teachers. To highlight the criteria, indicators, levels of development in the system of postgraduate education partial methodology is grounded, proprietary methods of research of its three components is proposed. Detailed description of criterion-level tools for evaluation of results of activity of a component of social competence elementary school teacher made the awareness of its semantic content and the relationship between the criteria, indicators and levels of regulation of the specific characteristics of the assessment system possible. The results will be useful in the characteristics of criterion-level instruments of other components of the designated competence and self-monitoring of primary school teachers and future teachers, awareness of the social significance of the

Development of grouting technologies for geological disposal of high level waste in Japan (1). Overall program and application of developed technologies

International Nuclear Information System (INIS)

Fujita, Tomoo; Sasamoto, Hiroshi; Sugita, Yutaka; Matsui, Hiroya

2013-01-01

The Japan Atomic Energy Agency started a grout project for geological disposal of high-level radioactive waste (HLW) in 2007. The aim of the project was to develop new grouting technologies and grout materials and also to develop models for performance assessments, prediction of the long-term radionuclide migration and identify detrimental changes in the host rock by the grout material leachate. This study presents the overall program and the application of key engineering technologies to the construction and operation of an underground facility for the geological disposal of HLW, with particular emphasis on the long-term effects of grout materials. (author)

ATLAS Level-1 Calorimeter Trigger: Status and Development

CERN Document Server

Bracinik, J; The ATLAS collaboration

2013-01-01

The ATLAS Level-1 Calorimeter Trigger seeds all the calorimeter-based triggers in the ATLAS experiment at LHC. The inputs to the system are analogue signals of reduced granularity, formed by summing cells from both the ATLAS Liquid Argon and Tile calorimeters. Several stages of analogue then digital processing, largely performed in FPGAs, refine these signals via configurable and flexible algorithms into identified physics objects, for example electron, tau or jet candidates. The complete processing chain is performed in a pipelined system at the LHC bunch-crossing frequency, and with a fixed latency of about 1us. The first LHC run from 2009-2013 provided a varied and challenging environment for first level triggers. While the energy and luminosity were below the LHC design, the pile-up conditions were similar to the nominal conditions. The physics ambitions of the experiment also tested the performance of the Level-1 system while keeping within the rate limits set by detector readout. This presentation will ...

Load leveling total system. Part 2. Development of load leveling logic for residential customer; Fuka heijunka total system. 2. Kateiyo juyoka wo taisho to shita heijunka ronri no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Asari, M.; Nanahara, T. [Central Research Institute of Electric Power Industry, Tokyo (Japan)

1995-05-01

It is essential, in order to meet steadily increasing demands for electrical power, to develop techniques for effective utilization of energy and load leveling. Described herein is development, by the aid of linear programming, of logic for daily management of charge/discharge of load conditioners and reverse power flow, for predicted loads and patterns of power generated by photovoltaic cells installed at individual customers. It is aimed at minimizing power rate and leveling of load at distribution systems. Predicted loads, outputs by photovoltaic cell units and different power rates by time zone for the next day are inputted, to determine the charge/discharge schedules and power supply/reverse flow patterns for that day, in order to minimize power rates and level loads at higher hierarchical levels. The logic-aided daily simulation for various districts confirms the operational patterns that realize improved utilization of pole-mounted transformers while reducing costs at customers, and effects of prediction errors. 4 refs., 14 figs.

Hypertension Knowledge-Level Scale (HK-LS): A Study on Development, Validity and Reliability

OpenAIRE

Erkoc, Sultan Baliz; Isikli, Burhanettin; Metintas, Selma; Kalyoncu, Cemalettin

2012-01-01

This study was conducted to develop a scale to measure knowledge about hypertension among Turkish adults. The Hypertension Knowledge-Level Scale (HK-LS) was generated based on content, face, and construct validity, internal consistency, test re-test reliability, and discriminative validity procedures. The final scale had 22 items with six sub-dimensions. The scale was applied to 457 individuals aged ≥18 years, and 414 of them were re-evaluated for test-retest reliability. The six sub-dimensio...

Change in the level of strength and endurance development of 5-6 grades pupils under cheerleading exercises influence

Directory of Open Access Journals (Sweden)

Tetyana Bala

2015-06-01

Full Text Available Purpose: determine the degree of change in the level of strength and endurance development of 5-6 grades pupils under cheerleading exercises influence. Material and Methods: theoretical analysis and generalization of scientific and methodical literature, pedagogical testing, pedagogical experiment and mathematical statistics methods. Results: parameters of strength and endurance development level are presented with their degree of change under cheerleading exercises influence for 5-6 grades pupils of secondary school. Conclusions: cheerleading exercises usage has positive influence on demonstrated strength and endurance degree of secondary school children by all investigated parameters.

Development of radiological profiles for U.S. Department of Energy low-level mixed wastes

International Nuclear Information System (INIS)

Wilkins, B.D.; Meshkov, N.K.; Dolak, D.A.; Wang, Y.Y.

1995-01-01

Radiological profiles have been developed by Argonne National Laboratory for low-level mixed wastes (LLMWs) that are under the management of the US Department of Energy (DOE). These profiles have been used in the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS) to support the analysis of environmental and health risks associated with the various waste management strategies. The radiological characterization of DOE LLMWs is generally inadequate and has made it difficult to develop a site- and waste-stream-dependent radiological profile for LLMWs. On the basis of the operational history of the DOE sites, a simple model was developed to generate site-dependent and waste-stream-independent radiological profiles for LLMWs. This paper briefly discusses the assumptions used in this model and the uncertainties in the results

Development of national level preparedness for response to nuclear and radiological emergencies

International Nuclear Information System (INIS)

Pradeepkumar, K.S.

2014-01-01

In India, DAE being the nodal agency for technical support for response to any radiation emergency nuclear disaster and various nuclear and radiological emergency scenarios and their impacts are identified. To reduce their consequences development of methodologies for detection and quick impact assessment, trained First Responders and Quick Response Teams (QRTs), twenty two DAE Emergency Response Centers, mobile and aerial radiation monitoring systems, aerial and ground based validation trials etc. are carried out. Study related to radiological threats and simulated RDD experiments conducted using stable isotopes indicates that radiation levels for distances more than 50 m will not be very high as hotspots may be restricted to nearby area. The biggest challenge from an RDD explosion will be handling of the radioactive contamination and 'fear factor' compared to radiation exposure to public or First Responders. Level and pattern of radioactive contamination on ground following releases during nuclear accidents and minimum strength of orphan radioactive sources to be detected are taken into account for optimizing systems and monitoring methodology required for emergency preparedness

Development of an accelerated leach test(s) for low-level waste forms

International Nuclear Information System (INIS)

Dougherty, D.R.; Fuhrmann, M.; Colombo, P.

1986-01-01

An accelerated leach test(s) is being developed to predict long-term leaching behavior of low-level radioactive waste (LLW) forms in their disposal environments. As necessary background, a literature survey of reported leaching mechanisms, available mathematical models and factors that affect leaching of LLW forms has been compiled. Mechanisms which have been identified include diffusion, dissolution, ion exchange, corrosion and surface effects. A computerized data base of LLW leaching data and mathematical models is being developed. The data is being used for model evaluation by curve fitting and statistical analysis according to standard procedures of statistical quality control. Long-term leach tests on portland cement, bitumen and vinyl ester-styrene (VES) polymer waste forms are underway which are designed to identify and evaluate factors that accelerate leaching without changing the mechanisms. Initial results on the effect of temperature on leachability indicate that the leach rates of cement and VES waste forms increase with increasing temperature, whereas, the leach rate of bitumen is little affected

Development of diagnostic test instruments to reveal level student conception in kinematic and dynamics

Science.gov (United States)

Handhika, J.; Cari, C.; Suparmi, A.; Sunarno, W.; Purwandari, P.

2018-03-01

The purpose of this research was to develop a diagnostic test instrument to reveal students' conceptions in kinematics and dynamics. The diagnostic test was developed based on the content indicator the concept of (1) displacement and distance, (2) instantaneous and average velocity, (3) zero and constant acceleration, (4) gravitational acceleration (5) Newton's first Law, (6) and Newton's third Law. The diagnostic test development model includes: Diagnostic test requirement analysis, formulating test-making objectives, developing tests, checking the validity of the content and the performance of reliability, and application of tests. The Content Validation Index (CVI) results in the category are highly relevant, with a value of 0.85. Three questions get negative Content Validation Ratio CVR) (-0.6), after revised distractors and clarify visual presentation; the CVR become 1 (highly relevant). This test was applied, obtained 16 valid test items, with Cronbach Alpha value of 0.80. It can conclude that diagnostic test can be used to reveal the level of students conception in kinematics and dynamics.

Closure Report for Corrective Action Unit 566: EMAD Compound, Nevada National Security Site, Nevada with ROTC-1, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Mark Krauss

2011-06-01

This Closure Report (CR) presents information supporting the closure of Corrective Action Unit (CAU) 566: EMAD Compound, Nevada National Security Site, Nevada. Corrective Action Unit 566 comprises Corrective Action Site (CAS) 25-99-20, EMAD Compound, located within Area 25 of the Nevada National Security Site. The purpose of this CR is to provide documentation supporting the completed corrective actions and provide data confirming that the closure objectives for CAU 566 were met. To achieve this, the following actions were performed: • Review the current site conditions, including the concentration and extent of contamination. • Implement any corrective actions necessary to protect human health and the environment. • Properly dispose of corrective action and investigation wastes. • Document Notice of Completion and closure of CAU 566 issued by the Nevada Division of Environmental Protection. From October 2010 through May 2011, closure activities were performed as set forth in the Streamlined Approach for Environmental Restoration Plan for CAU 566: EMAD Compound, Nevada National Security Site, Nevada. The purposes of the activities as defined during the data quality objectives process were as follows: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent, implement appropriate corrective actions, and properly dispose of wastes. Analytes detected during the closure activities were evaluated against final action levels (FALs) to determine COCs for CAU 566. Assessment of the data from collected soil samples, and from radiological and visual surveys of the site, indicates the FALs were exceeded for polychlorinated biphenyls (PCBs), semivolatile organic compounds (SVOCs), and radioactivity. Corrective actions were implemented to remove the following: • Radiologically contaminated soil assumed greater than FAL at two locations • Radiologically contaminated soil assumed greater than FAL with

A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels.

Science.gov (United States)

Hallaq, Haifa; Pinter, Emese; Enciso, Josephine; McGrath, James; Zeiss, Caroline; Brueckner, Martina; Madri, Joseph; Jacobs, Harris C; Wilson, Christine M; Vasavada, Hemaxi; Jiang, Xiaobing; Bogue, Clifford W

2004-10-01

The homeobox gene Hhex has recently been shown to be essential for normal liver, thyroid and forebrain development. Hhex(-/-) mice die by mid-gestation (E14.5) and the cause of their early demise remains unclear. Because Hhex is expressed in the developing blood islands at E7.0 in the endothelium of the developing vasculature and heart at E9.0-9.5, and in the ventral foregut endoderm at E8.5-9.0, it has been postulated to play a critical role in heart and vascular development. We show here, for the first time, that a null mutation of Hhex results in striking abnormalities of cardiac and vascular development which include: (1) defective vasculogenesis, (2) hypoplasia of the right ventricle, (3) overabundant endocardial cushions accompanied by ventricular septal defects, outflow tract abnormalities and atrio-ventricular (AV) valve dysplasia and (4) aberrant development of the compact myocardium. The dramatic enlargement of the endocardial cushions in the absence of Hhex is due to decreased apoptosis and dysregulated epithelial-mesenchymal transformation (EMT). Interestingly, vascular endothelial growth factor A (Vegfa) levels in the hearts of Hhex(-/-) mice were elevated as much as three-fold between E9.5 and E11.5, and treatment of cultured Hhex(-/-) AV explants with truncated soluble Vegfa receptor 1, sFlt-1, an inhibitor of Vegf signaling, completely abolished the excessive epithelial-mesenchymal transformation seen in the absence of Hhex. Therefore, Hhex expression in the ventral foregut endoderm and/or the endothelium is necessary for normal cardiovascular development in vivo, and one function of Hhex is to repress Vegfa levels during development.

Advanced High-Level Waste Glass Research and Development Plan

Energy Technology Data Exchange (ETDEWEB)

Peeler, David K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vienna, John D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schweiger, Michael J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fox, Kevin M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2015-07-01

The U.S. Department of Energy Office of River Protection (ORP) has implemented an integrated program to increase the loading of Hanford tank wastes in glass while meeting melter lifetime expectancies and process, regulatory, and product quality requirements. The integrated ORP program is focused on providing a technical, science-based foundation from which key decisions can be made regarding the successful operation of the Hanford Tank Waste Treatment and Immobilization Plant (WTP) facilities. The fundamental data stemming from this program will support development of advanced glass formulations, key process control models, and tactical processing strategies to ensure safe and successful operations for both the low-activity waste (LAW) and high-level waste (HLW) vitrification facilities with an appreciation toward reducing overall mission life. The purpose of this advanced HLW glass research and development plan is to identify the near-, mid-, and longer-term research and development activities required to develop and validate advanced HLW glasses and their associated models to support facility operations at WTP, including both direct feed and full pretreatment flowsheets. This plan also integrates technical support of facility operations and waste qualification activities to show the interdependence of these activities with the advanced waste glass (AWG) program to support the full WTP mission. Figure ES-1 shows these key ORP programmatic activities and their interfaces with both WTP facility operations and qualification needs. The plan is a living document that will be updated to reflect key advancements and mission strategy changes. The research outlined here is motivated by the potential for substantial economic benefits (e.g., significant increases in waste throughput and reductions in glass volumes) that will be realized when advancements in glass formulation continue and models supporting facility operations are implemented. Developing and applying advanced

Advanced waste form and melter development for treatment of troublesome high-level wastes

Energy Technology Data Exchange (ETDEWEB)

Marra, James [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Kim, Dong -Sang [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Maio, Vincent [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-02

A number of waste components in US defense high level radioactive wastes (HLW) have proven challenging for current Joule heated ceramic melter (JHCM) operations and have limited the ability to increase waste loadings beyond already realized levels. Many of these "troublesome" waste species cause crystallization in the glass melt that can negatively impact product quality or have a deleterious effect on melter processing. Recent efforts at US Department of Energy laboratories have focused on understanding crystallization behavior within HLW glass melts and investigating approached to mitigate the impacts of crystallization so that increases in waste loading can be realized. Advanced glass formulations have been developed to highlight the unique benefits of next-generation melter technologies such as the Cold Crucible Induction Melter (CCIM). Crystal-tolerant HLW glasses have been investigated to allow sparingly soluble components such as chromium to crystallize in the melter but pass out of the melter before accumulating.

Probe and Sensors Development for Level Measurement of Fats, Oils and Grease in Grease Boxes

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José Faria

2016-09-01

Full Text Available The wide spread of food outlets has become an environmental and sanitation infrastructure problem, due to Fats, Oils and Grease (FOG. A grease box is used at the industrials facilities to collect the FOG, in a specific time window, while its quality is good for recycling (e.g., biodiesel and it is economically valuable. After this period, it will be disposed at a cost. For the proper management of the grease boxes, it is necessary to know the quantity of FOG inside the boxes, which is a major problem, as the boxes are sealed and permanently filled with water. The lack of homogeneity of the FOG renders it not detectable by current probes for level detection in liquids. In this article, the design, development and testing of a set of probes for FOG level measurement, based on the principles used in sensors for the detection of liquids inside containers, is described. The most suitable probe, based on the capacitance principle, together with the necessary hardware and software modules for data acquisition and transmission, was developed and tested. After the development phase, the probe was integrated on a metropolitan system for FOG collection and grease box management in partnership with a grease box management company.

Corrective Action Decision Document/Closure Report for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe Nevada Test Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Patrick Matthews

2010-07-01

This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit 371, Johnnie Boy Crater and Pin Stripe, located within Areas 11 and 18 at the Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit (CAU) 371 comprises two corrective action sites (CASs): • 11-23-05, Pin Stripe Contamination Area • 18-45-01, U-18j-2 Crater (Johnnie Boy) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 371 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at both CASs. Corrective action investigation (CAI) activities were performed from January 8, 2009, through February 16, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 371: Johnnie Boy Crater and Pin Stripe. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 371 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were not found to be present in the surface soil. However, it was assumed that radionuclides are present in subsurface media within the Johnnie Boy crater and the fissure at Pin Stripe. Due to the assumption of radiological dose exceeding the FAL, corrective actions were undertaken

Examining the Satisfaction Levels of Continual Professional Development Provided by a Rural Accounting Professional Body

Science.gov (United States)

Halabi, Abdel K.

2014-01-01

The Society for the Provision of Education in Rural Australia (SPERA) recognises education as a lifelong process, and there is a need for continuing education and training to be available to rural communities. This paper examines the satisfaction levels of accounting continual professional development (CPD) when provided by a rural accounting…

Sex steroid hormone levels and reproductive development of eight-year-old children following in utero and environmental exposure to phthalates.

Directory of Open Access Journals (Sweden)

Pen-Hua Su

Full Text Available In utero exposure to phthalates may adversely affect reproductive development in children due to the anti-androgenic properties of the pthalates. Accordingly, we aimed to determine the effects of in utero and environmental phthalate exposure on the reproductive development of eight-year-old children. We recruited 180 children in central Taiwan during November 2001 and followed them until August 2009 when all children became eight years old. Birth outcomes were collected. Bone age, hormone concentrations, and reproductive developmental stages were determined. Phthalate metabolite levels, including mono-2-ethylhexyl phthalate [MEHP], mono-n-butyl phthalate [MnBP], and mono-benzyl phthalate [MBzP], were assessed. No significant gender differences were found in in utero phthalate exposure. Maternal urinary levels of phthalate metabolites did not correlate significantly with birth outcomes, physical characteristics, and reproductive hormones of the eight-year-old children. Regarding the urinary phthalate metabolite levels of the eight-year-old children, MEHP correlated significantly with serum progesterone levels. MEHP levels in girls correlated significantly with serum progesterone levels. MnBP correlated significantly with serum FSH in all children. In girls, MnBP correlated with serum FSH, and MBzP correlated with serum progesterone and FSH levels. Urinary phthalate metabolite levels did not correlate with female developmental stages or the development of female reproductive organs. Phthalate metabolites did not correlate with the physical characteristics and reproductive hormones in boys. Therefore, environmental exposure to phthalates, as determined by urinary phthalate metabolite levels of eight-year-old children, may affect reproductive hormone levels in children, indicating that further studies on the environmental health effects of phthalates are warranted.

Utilization of critical periods during development to study the effects of low levels of environmental agents

International Nuclear Information System (INIS)

Russell, L.B.

1981-01-01

This chapter shows how careful definition of critical periods in the development of selected characters can result in experimental systems that may be highly useful in studying risk at low levels of exposure. Presents 3 systems that utilize critical periods to study low-level effects: 1) cell kinetics as an indicator of nervous-system maldevelopment; 2) oocyte depletion; and 3) homeotic shifts in the skeleton. Discusses application of the sensitive systems to the testing of chemicals and the role of sensitive stages in estimating risk. Suggests that tests such as the 3 discussed in this paper, which are developed with strict attention to specific critical periods, can provide rapid and sensitive means for revealing whether an agent is capable of causing developmental interference. Concludes that epidemiological investigations can lose much of their value unless critical periods are known for the endpoints being studied

SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS

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Pamela Milani

2011-01-01

Full Text Available Copper-zinc superoxide dismutase (SOD1 is a detoxifying enzyme localized in the cytosol, nucleus, peroxisomes, and mitochondria. The discovery that mutations in SOD1 gene cause a subset of familial amyotrophic lateral sclerosis (FALS has attracted great attention, and studies to date have been mainly focused on discovering mutations in the coding region and investigation at protein level. Considering that changes in SOD1 mRNA levels have been associated with sporadic ALS (SALS, a molecular understanding of the processes involved in the regulation of SOD1 gene expression could not only unravel novel regulatory pathways that may govern cellular phenotypes and changes in diseases but also might reveal therapeutic targets and treatments. This review seeks to provide an overview of SOD1 gene structure and of the processes through which SOD1 transcription is controlled. Furthermore, we emphasize the importance to focus future researches on investigating posttranscriptional mechanisms and their relevance to ALS.

Audiovisual speech perception development at varying levels of perceptual processing.

Science.gov (United States)

Lalonde, Kaylah; Holt, Rachael Frush

2016-04-01

This study used the auditory evaluation framework [Erber (1982). Auditory Training (Alexander Graham Bell Association, Washington, DC)] to characterize the influence of visual speech on audiovisual (AV) speech perception in adults and children at multiple levels of perceptual processing. Six- to eight-year-old children and adults completed auditory and AV speech perception tasks at three levels of perceptual processing (detection, discrimination, and recognition). The tasks differed in the level of perceptual processing required to complete them. Adults and children demonstrated visual speech influence at all levels of perceptual processing. Whereas children demonstrated the same visual speech influence at each level of perceptual processing, adults demonstrated greater visual speech influence on tasks requiring higher levels of perceptual processing. These results support previous research demonstrating multiple mechanisms of AV speech processing (general perceptual and speech-specific mechanisms) with independent maturational time courses. The results suggest that adults rely on both general perceptual mechanisms that apply to all levels of perceptual processing and speech-specific mechanisms that apply when making phonetic decisions and/or accessing the lexicon. Six- to eight-year-old children seem to rely only on general perceptual mechanisms across levels. As expected, developmental differences in AV benefit on this and other recognition tasks likely reflect immature speech-specific mechanisms and phonetic processing in children.

Towards the development of cascaded surface plasmon resonance POF sensors exploiting gold films and synthetic recognition elements for detection of contaminants in transformer oil

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M. Pesavento

2017-04-01

Full Text Available The possibility of developing a multichannel optical chemical sensor, based on molecularly imprinted polymers (MIPs and surface plasmon resonance (SPR in a D-shaped multimode plastic optical fiber (POF, is presented by two cascaded SPR-POF-MIP sensors with different thicknesses of the gold layer. The low cost, the high selectivity and sensitivity of the SPR-POF-MIP platforms and the simple and modular scheme of the optical interrogation layout make this system a potentially suitable on-line multi-diagnostic tool. As a proof of principle, the possibility of simultaneous determination of two important analytes, dibenzyl disulfide (DBDS and furfural (2-FAL, in power transformer oil was investigated. Their presence gives useful indication of underway corrosive or ageing processes in power transformers, respectively. Preliminarily, the dependence of the performance of the D-shaped optical platform on the gold film thickness has been studied, comparing two platforms with 30 nm and 60 nm thick gold layers. It has been found that the resonance wavelengths are different on platforms with gold layer of different thickness, furthermore when MIPs are present on the gold as receptors, the performances of the platforms are similar in the two considered sensors. Keywords: Cascaded multianalyte detection, Surface plasmon resonance, Dibenzyl disulfide, Furfural (furan-2-carbaldehyde, Molecularly imprinted polymers, Plastic optical fibers

Development of Concentration and Calcination Technology For High Level Liquid Waste

International Nuclear Information System (INIS)

Pande, D.P.

2006-01-01

The concentrated medium and high-level liquid radio chemicals effluents contain nitric acid, water along with the dissolved chemicals including the nitrates of the radio nuclides. High level liquid waste contain mainly nitrates of cesium, strontium, cerium, zirconium, chromium, barium, calcium, cobalt, copper, pickle, iron etc. and other fission products. This concentrated solution requires further evaporation, dehydration, drying and decomposition in temperature range of 150 to 700 deg. C. The addition of the calcined solids in vitrification pot, instead of liquid feed, helps to avoid low temperature zone because the vaporization of the liquid and decomposition of nitrates do not take place inside the melter. In our work Differential and thermo gravimetric studies has been carried out in the various stages of thermal treatment including drying, dehydration and conversion to oxide forms. Experimental studies were done to characterize the chemicals present in high-level radioactive waste. A Rotary Ball Kiln Calciner was used for development of the process because this is amenable for continuous operation and moderately good heat transfer can be achieved inside the kiln. This also has minimum secondary waste and off gases generation. The Rotary Ball Kiln Calciner Demonstration facility system was designed and installed for the demonstration of calcination process. The Rotary Ball Kiln Calciner is a slowly rotating slightly inclined horizontal tube that is externally heated by means of electric resistance heating. The liquid feed is sprayed onto the moving bed of metal balls in a slowly rotating calciner by a peristaltic type-metering pump. The vaporization of the liquid occurs in the pre-calcination zone due to counter current flow of hot gases. The dehydration and denitration of the solids occurs in the calcination zone, which is externally heated by electrical furnace. The calcined powder is cooled in the post calcination portion. It has been demonstrated that the

Low-level waste research and development activities of the Department of Energy

International Nuclear Information System (INIS)

Barainca, M.J.

1986-01-01

This paper presents an overview of the technical activities of the Department of Energy's Defense and Nuclear Energy Low-Level Radioactive Waste Management Programs (LLWPs). Although each Program was established with a different purpose, the technologies developed and demonstrated by each are transferable for use in both the commercial and DOE sectors. This paper presents an overview of the technical activities being pursued through both the Defense and Nuclear Energy LLWP's. These technologies have been placed in the following categories; Criteria and Standards, Systems Analysis, Information and Technology Transfer, Waste Treatment and Wast Form, Improved Near Surface Disposal, Greater Confinement Disposal, Corrective Measures, and Monitoring

Development of an omnidirectional gamma-ray imaging Compton camera for low-radiation-level environmental monitoring

Science.gov (United States)

Watanabe, Takara; Enomoto, Ryoji; Muraishi, Hiroshi; Katagiri, Hideaki; Kagaya, Mika; Fukushi, Masahiro; Kano, Daisuke; Satoh, Wataru; Takeda, Tohoru; Tanaka, Manobu M.; Tanaka, Souichi; Uchida, Tomohisa; Wada, Kiyoto; Wakamatsu, Ryo

2018-02-01

We have developed an omnidirectional gamma-ray imaging Compton camera for environmental monitoring at low levels of radiation. The camera consisted of only six CsI(Tl) scintillator cubes of 3.5 cm, each of which was readout by super-bialkali photo-multiplier tubes (PMTs). Our camera enables the visualization of the position of gamma-ray sources in all directions (∼4π sr) over a wide energy range between 300 and 1400 keV. The angular resolution (σ) was found to be ∼11°, which was realized using an image-sharpening technique. A high detection efficiency of 18 cps/(µSv/h) for 511 keV (1.6 cps/MBq at 1 m) was achieved, indicating the capability of this camera to visualize hotspots in areas with low-radiation-level contamination from the order of µSv/h to natural background levels. Our proposed technique can be easily used as a low-radiation-level imaging monitor in radiation control areas, such as medical and accelerator facilities.

The reduction in circulating levels of melatonin may be associated with the development of preeclampsia.

Science.gov (United States)

Zeng, K; Gao, Y; Wan, J; Tong, M; Lee, A C; Zhao, M; Chen, Q

2016-11-01

Placental dysfunction and oxidative stress contribute to the pathogenesis of preeclampsia, which is a pregnancy-specific disorder. It has been suggested that the incidence of preeclampsia has a seasonal variation. Melatonin, as a seasonal factor, has been suggested to be involved in a successful pregnancy. In this study, we investigated the association of circulating levels of melatonin with preeclampsia. Serum was collected from women with preeclampsia (n=113) and gestation-matched healthy pregnant women, and the levels of melatonin were measured. In addition, the expression of melatonin receptors was examined in preeclamptic placentae (n=27). The association of the incidence of preeclampsia and seasonal variation was also analysed from 1491 women with preeclampsia within 77 745 healthy pregnancies. The serum levels of melatonin were significantly reduced in women with preeclampsia at presentation and these reduced serum levels of melatonin were not associated with the severity or time onset of preeclampsia nor with seasonal variation. The expression of melatonin receptor, MT1 was reduced in preeclamptic placentae. The incidence of preeclampsia was did exhibit seasonal variation, but this was largely due to the increase in the incidence of mild or late-onset preeclampsia. Our results demonstrate that reduced melatonin levels are associated with the development of preeclampsia but that the circulating levels of melatonin do not appear to be subject to seasonal variation during pregnancy.

The story of a narrative: Teaching and assessing English writing in a township school

Directory of Open Access Journals (Sweden)

Caroline Akinyeye

2016-05-01

Full Text Available The new language curriculum in South Africa recommends that extended writing be taught through a combination of text-based (or genre and process approaches. This article reports on a study of the teaching and assessment of narrative writing in English as a first additional language (FAL at a time of curriculum change. The setting is a Cape Flats township school. In focusing on a story written by a Grade 9 learner and assessed by her teacher, the study sought evidence of the use of text-based and process approaches. The theoretical frame is informed by genre theory, which draws on Systemic Functional Linguistics and social constructivist approaches to language learning. A qualitative research paradigm was used. Data obtained for this case study included the learner’s writing, interviews with the teacher, and classroom observation. The study finds very little evidence of a scaffolded approach to the teaching and assessment of writing, and explores the constraints on the realisation of the curriculum cycle in English FAL. These relate to the teacher’s understanding of writing as well as to material conditions in township schools.

CRIMES EM ESPÉCIE NA LEI Nº 11.101/2005: UMA ANÁLISE CRÍTICA

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Helena Beatriz de Moura Belle

2015-12-01

Full Text Available No presente artigo tem-se por objetivo apresentar e analisar os tipos penais dispostos na Lei nº 11.101, de 9 de fevereiro de 2005, que regula a recuperação judicial e extrajudicial e a falência do empresário e da sociedade empresária. A metodologia de pesquisa adotada foi a qualitativa e procedimentos metodológicos por análise documental, mediante utilização de fontes bibliográficas e ordenamento jurídico brasileiro vigente. Verificou-se que não há convergências entre os doutrinadores a respeito da tipificação determinada na referida lei e que, indubitavelmente, todos os ilícitos ali especificados também são qualificados no Código Penal brasileiro, Decreto-Lei nº 2.848/1940, com diferenças no que se refere ao tempo de cumprimento de penas, causas atenuantes e agravantes. Assim, compreende-se que os dispositivos penais contidos na lei especial servem muito mais para identificar e qualificar os ilícitos cometidos nas fases dos dois institutos analisados, recuperação e falência de devedor insolvente.

Developing a Dual-Level Capabilities Approach: Using Constructivist Grounded Theory and Feminist Ethnography to Enhance the Capabilities Approaches

Science.gov (United States)

Hall, Kia M. Q.

2014-01-01

In this study, a dual-level capabilities approach to development is introduced. This approach intends to improve upon individual-focused capabilities approaches developed by Amartya Sen and Martha Nussbaum. Based upon seven months of ethnographic research in the Afro-descendant, autochthonous Garifuna community of Honduras, constructivist grounded…

Building a System of Comparative-Spatial Assessment of the Level of Development of Ukraine and the EU Countries

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Bril Mykhailo S.

2018-02-01

Full Text Available The article proposes an approach to the formation of a system of comparative-spatial assessment of the level of socio-economic development of the State, on the basis of which the multidimensional statistical analysis of Ukraine and the EU countries was accomplished. On the basis of the hierarchical agglomerative and iterative methods of the spatial cluster analysis, groups of countries are allocated by homogeneous characteristics of the socio-economic development. A comparison of the results of spatial and dynamic clustering confirms the stability of the composition of the allocated groups and their quality characteristics. The proposed complex of economic and mathematical models for determining the level of socio-economic development of the State and the EU countries on the basis of assessment and analysis of the main macro-indicators and their relationship in the perspective will improve the quality of managerial decisions as to ensuring the socio-economic development of the State.

Symposium on the development of nuclear waste policy: Siting the high-level nuclear waste repository

International Nuclear Information System (INIS)

Pijawka, K.D.; Mushkatel, A.H.

1991-01-01

The Nuclear Waste Policy Act of 1982 (NWPA) attempted to formulate a viable national policy for managing the disposal of high-level nuclear wastes. The NWPA authorized the selection of two repository sites: the first to be constructed in the West and a second site developed in the eastern United States. A detailed process for site selection was outlined in the NWPA. In addition, the NWPA authorized open-quotes the development of a waste transportation system; required the Department of Energy (DOE) to submit a proposal to construct a facility for monitored retrievable storage (MRS) after conducting a study of the need for, and feasibility of such a facility; and required the President to evaluate the use of the repositories ... for the disposal of high-level waste resulting from defense activitiesclose quotes (DOE, 1988, p. 1). A series of provisions granting oversight participation to states and Indian tribes, as well as a compensation package for the ultimate host state were also included. Responsibility for implementing the NWPA was assigned to DOE

Development of a low level radioactive waste disposal site in Texas - 1994 status

International Nuclear Information System (INIS)

Jacobi, L.R. Jr.

1995-01-01

The Texas Low Level Radioactive Waste Disposal Authority, an agency of the State of Texas, has been trying to develop a site for the disposal of low level radioactive waste in Texas for over ten years. Since 1991, the agency has been evaluating a site near Sierra Blanca, in far west Texas. Site characterization has been completed and a license application has been filed with the Texas Natural Resource Conservation Commission. Construction plans were completed in 1993, and the agency is prepared to begin construction and operations as soon as a license can be issued. Development costs for the site are borne by the utility companies and other major generators in Texas through the assessment of a planning and implementation fee. Total costs to date are approximately $26 million. As the project moves toward completion, state and national anti-nuclear activist groups have become more involved in attempts to thwart the Texas government's effort to solve the radioactive waste problem. To counter this increased opposition, the Texas utility companies and medical radioactive waste generators have also become more active in responding to these groups. This has been very helpful and is in keeping with the elements of building block 12 of the Nuclear Power Oversight Committee's Strategic Plan for Building New Nuclear Power Plants. This paper and poster session look at the schedule, design, and long term prospects for ultimate success of the project

Development of a questionnaire to assess interprofessional collaboration between two different care levels

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Roberto Nuño Solinís

2013-04-01

Full Text Available Introduction. This paper reports the development and validation of a questionnaire to assess collaboration between clinical professionals from two different care levels (primary and specialised care, according to the clinicians' own perceptions. This questionnaire has been elaborated to be used as part of the monitoring and evaluation process of the integrated care pilots in the public Basque Health Service. Methods. The process was carried out in four phases: development of the first version of the questionnaire, validation of the content, pre-testing, and evaluation of its construct validity and homogeneity in a sample of doctors and nurses. This last phase involved confirmatory factor analysis, as well as the calculation of Cronbach's α and various correlation coefficients. Results. The process demonstrated that the theoretical content of the questionnaire was appropriate, and also that its items were clear, relevant and intelligible. The fit indices for the confirmatory factor analysis were: c2 of 45.51 (p = 0.089, RMSEA of 0.043, RMR of 0.046, GFI of 0.92 and CFI of 0.99. Discussion. The statistics indicate a good fit between the data and a conceptual two-factor structure, in which both personal relationships between professionals and characteristics of the organisational environment are understood to underlie interprofessional collaboration. Conclusion. The end-product is a new instrument with good validity to assess the degree of interprofessional collaboration between clinicians working at two different levels of care.

Development of a questionnaire to assess interprofessional collaboration between two different care levels

Directory of Open Access Journals (Sweden)

Roberto Nuño Solinís

2013-04-01

Full Text Available Introduction. This paper reports the development and validation of a questionnaire to assess collaboration between clinical professionals from two different care levels (primary and specialised care, according to the clinicians' own perceptions. This questionnaire has been elaborated to be used as part of the monitoring and evaluation process of the integrated care pilots in the public Basque Health Service.Methods. The process was carried out in four phases: development of the first version of the questionnaire, validation of the content, pre-testing, and evaluation of its construct validity and homogeneity in a sample of doctors and nurses. This last phase involved confirmatory factor analysis, as well as the calculation of Cronbach's α and various correlation coefficients.Results. The process demonstrated that the theoretical content of the questionnaire was appropriate, and also that its items were clear, relevant and intelligible. The fit indices for the confirmatory factor analysis were: c2 of 45.51 (p = 0.089, RMSEA of 0.043, RMR of 0.046, GFI of 0.92 and CFI of 0.99.Discussion. The statistics indicate a good fit between the data and a conceptual two-factor structure, in which both personal relationships between professionals and characteristics of the organisational environment are understood to underlie interprofessional collaboration.Conclusion. The end-product is a new instrument with good validity to assess the degree of interprofessional collaboration between clinicians working at two different levels of care.

DEVELOPING SITE-SPECIFIC DERIVED CONCENTRATION GUIDELINE LEVELS FOR MULTIPLE MEDIA AT THE CONNECTICUT YANKEE HADDAM NECK PLANT

International Nuclear Information System (INIS)

Taylor, S.W.; Smith, L.C.; Carr, R.K.; Carson, A.; Darois, E.

2003-01-01

As part of the license termination process, site-specific Derived Concentration Guideline Levels for the Haddam Neck Plant site are developed for soil, groundwater, concrete left standing, and concrete demolished that satisfy the radiological criteria for unrestricted use as defined in 10 CFR 20.1402. Background information on the license termination process and characteristics of the Haddam Neck Plant site are presented. The dose models and associated resident farmer and building occupancy scenarios, applicable pathways, and critical groups developed to establish the Derived Concentration Guideline Levels are described. A parameter assignment process is introduced wherein general population values are used to establish behavioral and metabolic parameters representative of an average member of the critical group, while the uncertainty associated with important physical parameters is considered. A key element of the parameter assignment process is the use of sensitivity analysis to identify the dose sensitive physical parameters and to ensure that such parameters are assigned conservative values. Structuring the parameter assignment process, completing the formal sensitivity analyses, and assigning conservative values to the sensitive physical parameters in a consistent way establishes a calculation framework that lead to Derived Concentration Guideline Levels with a uniform level of conservatism across all media and all radionuclides

Plant growth and development vs. high and low levels of plant-beneficial heavy metal ions

Directory of Open Access Journals (Sweden)

Namira Arif

2016-11-01

Full Text Available Heavy metals (HMs exists in the environment in both forms as essential and non-essential. These HM ions enter in soil biota from various sources like natural and anthropogenic. Essential HMs such as cobalt (Co, copper (Cu, iron (Fe, manganese (Mn, molybdenum (Mo, nickel (Ni, and zinc (Zn plays a beneficial role in plant growth and development. At optimum level these beneficial elements improves the plant’s nutritional level and also several mechanisms essential for the normal growth and better yield of plants. The range of their optimality for land plants is varied. Plant uptake heavy metals as a soluble component or solubilized them by root exudates. While their presence in excess become toxic for plants that switches the plant’s ability to uptake and accumulate other nonessential elements. The increased amount of HMs within the plant tissue displays direct and indirect toxic impacts. Such direct effects are the generation of oxidative stress which further aggravates inhibition of cytoplasmic enzymes and damage to cell structures. Although, indirect possession is the substitution of essential nutrients at plant’s cation exchange sites. These ions readily influence role of various enzymes and proteins, arrest metabolism, and reveal phytotoxicity. On account of recent advancements on beneficial HMs ions Co, Cu, Fe, Mn, Mo, Ni, and Zn in soil-plant system, the present paper: overview the sources of HMs in soils and their uptake and transportation mechanism, here we have discussed the role of metal transporters in transporting the essential metal ions from soil to plants. The role played by Co, Cu, Fe, Mn, Mo, Ni, and Zn at both low and high level on the plant growth and development and the mechanism to alleviate metal toxicity at high level have been also discussed. At the end, on concluding the article we have also discussed the future perspective in respect to beneficial HM ions interaction with plant at both levels.

Influence of the blood glucose level on the development of retinopathy of prematurity in extremely premature children.

Science.gov (United States)

Nicolaeva, Galina V; Sidorenko, Evgenyj I; Iosifovna, Amkhanitskaya Lyubov

2015-01-01

To investigate the influence of the blood glucose level on the development of retinopathy of prematurity (ROP) in extremely premature infants. Sixty-four premature infants with a gestational age of less than 30 weeks and a birth weight of less than 1500 g were included in the study. Children without ROP were allocated to Group 1 (n=14, gestational age 28.6 ± 1.4 weeks, birth weight 1162 ± 322 g), and children with spontaneous regression of ROP were allocated to Group 2 (n=32, gestational age 26.5 ± 1.2 weeks, birth weight 905 ± 224 g). Children with progressive ROP who underwent laser treatment were included in Group 3 (n=18, gestational age 25.4 ± 0.7 weeks, birth weight 763 ± 138 g). The glucose level in the capillary blood of the premature infants was monitored daily during the first 3 weeks of life. A complete ophthalmological screening was performed from the age of 1 month. The nonparametric signed-rank Wilcoxon-Mann-Whitney test was used for statistical analysis. The mean blood glucose level was 7.43 ± 2.6 mmol/L in Group 1, 7.8 ± 2.7 mmol/L in Group 2, and 6.7 ± 2.6 mmol/L in Group 3. There were no significant differences in the blood glucose levels between children with and without ROP, and also between children with spontaneously regressing ROP and progressive ROP (p>0.05). Additionally, there were no significant differences in the blood glucose levels measured at the first, second, and third weeks of life (p>0.05). The blood glucose level is not related to the development of ROP nor with its progression or regression. The glycemic level cannot be considered as a risk factor for ROP, but reflects the severity of newborns' somatic condition and morphofunctional immaturity.

The effect of Ramadan fasting on maternal serum lipids, cortisol levels and fetal development.

Science.gov (United States)

Dikensoy, Ebru; Balat, Ozcan; Cebesoy, Bahar; Ozkur, Ayhan; Cicek, Hulya; Can, Gunay

2009-02-01

To determine the effects of fasting during the month of Ramadan on fetal development and maternal serum cortisol and lipid profile. This study was performed in Obstetrics and Gynecology Department of Gaziantep University Hospital, between 23 September 2006 and 23 October 2006 (during the month of Ramadan). Thirty-six consecutive healthy women with uncomplicated pregnancies of 20 weeks or more, who were fasting during Ramadan, were included in the study group (group 1). The control group (group 2) consisted of 29 healthy pregnant women, who were not fasting during the study period. For evaluating Ramadan's effect on fetus, Doppler ultrasonography was performed on all subjects in the beginning and then once a week until the end of Ramadan for the following measurements: increase of fetal biparietal diameter (BPD), increase of fetal femur length (FL), increase of estimated fetal body weight (EFBW), fetal biophysical profile (BPP), amniotic fluid index (AFI), and umbilical artery systole/diastole (S/D) ratio. Maternal serum cortisol, triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL), and LDL/HDL ratio were also evaluated before and after Ramadan. No significant difference was found between the two groups for the fetal age, maternal weight gain (kilogram), estimated fetal weight gain (EFWG), fetal BPP, AFI, and umbilical artery S/D ratio. In the fasting group, the maternal serum cortisol levels on day 20 were significantly higher than the initial levels obtained 1 week prior to Ramadan (p Ramadan. HDL levels showed a slight increase, but LDL/HDL ratios were significantly decreased in fasting group (p Ramadan. No untoward effect of Ramadan was observed on intrauterine fetal development.

Summary Report for the Evaluation of Current QA Processes Within the FRMAC FAL and EPA MERL.

Energy Technology Data Exchange (ETDEWEB)

Shanks, Sonoya T.; Ted Redding; Lynn Jaussi; Allen, Mark B.; Fournier, Sean Donovan; Leonard, Elliott J.

2017-04-01

The Federal Radiological Monitoring and Assessment Center (FRMAC) relies on accurate and defensible analytical laboratory data to support its mission. Therefore, FRMAC must ensure that the environmental analytical laboratories providing analytical services maintain an ongoing capability to provide accurate analytical results to DOE. It is undeniable that the more Quality Assurance (QA) and Quality Control (QC) measures required of the laboratory, the less resources that are available for analysis of response samples. Being that QA and QC measures in general are understood to comprise a major effort related to a laboratory’s operations, requirements should only be considered if they are deemed “value-added” for the FRMAC mission. This report provides observations of areas for improvement and potential interoperability opportunities in the areas of Batch Quality Control Requirements, Written Communications, Data Review Processes, Data Reporting Processes, along with the lessons learned as they apply to items in the early phase of a response that will be critical for developing a more efficient, integrated response for future interactions between the FRMAC and EPA assets.

Closure Report for Corrective Action Unit 539: Areas 25 and 26 Railroad Tracks Nevada National Security Site, Nevada with ROTC-1, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Mark Kauss

2011-06-01

, 2010, through May 2, 2011, closure activities were performed as set forth in the Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 539: Areas 25 and 26 Railroad Tracks, Nevada Test Site, Nevada. The purposes of the activities as defined during the data quality objectives process were as follows: • Determine whether contaminants of concern (COCs) are present. • If COCs are present, determine their nature and extent, implement appropriate corrective actions, and properly dispose of wastes. Analytes detected during the closure activities were evaluated against final action levels (FALs) to determine COCs for CAU 539. Assessment of the data generated from closure activities revealed the following: • At CAS 26-99-05, the total effective dose for radiological releases did not exceed the FAL of 25 millirem per Industrial Area year. Potential source material in the form of lead bricks was found at three locations. A corrective action of clean closure was implemented at these locations, and verification samples indicated that no further action is necessary. • At CAS 25-99-21, the total effective dose for radiological releases exceeds the FAL of 25 millirem per Industrial Area year. Potential source material in the form of lead bricks was found at eight locations. A corrective action was implemented by removing the lead bricks and soil above FALs at these locations, and verification samples indicated that no further action is necessary. Pieces of debris with high radioactivity were identified as PSM and remain within the CAS boundary. A corrective action of closure in place with a UR was implemented at this CAS because closure activities showed evidence of remaining soil contamination and radioactive PSM. Future land use will be restricted from surface and intrusive activities. Closure activities generated waste streams consisting of industrial solid waste, recyclable materials, low-level radioactive waste, and mixed low-level

Closure Report for Corrective Action Unit 539: Areas 25 and 26 Railroad Tracks Nevada National Security Site, Nevada, Revision 0

International Nuclear Information System (INIS)

Kauss, Mark

2011-01-01

November 29, 2010, through May 2, 2011, closure activities were performed as set forth in the Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 539: Areas 25 and 26 Railroad Tracks, Nevada Test Site, Nevada. The purposes of the activities as defined during the data quality objectives process were as follows: (1) Determine whether contaminants of concern (COCs) are present; and (2) If COCs are present, determine their nature and extent, implement appropriate corrective actions, and properly dispose of wastes. Analytes detected during the closure activities were evaluated against final action levels (FALs) to determine COCs for CAU 539. Assessment of the data generated from closure activities revealed the following: (1) At CAS 26-99-05, the total effective dose for radiological releases did not exceed the FAL of 25 millirem per Industrial Area year. Potential source material in the form of lead bricks was found at three locations. A corrective action of clean closure was implemented at these locations, and verification samples indicated that no further action is necessary. (2) At CAS 25-99-21, the total effective dose for radiological releases exceeds the FAL of 25 millirem per Industrial Area year. Potential source material in the form of lead bricks was found at eight locations. A corrective action was implemented by removing the lead bricks and soil above FALs at these locations, and verification samples indicated that no further action is necessary. Pieces of debris with high radioactivity were identified as PSM and remain within the CAS boundary. A corrective action of closure in place with a UR was implemented at this CAS because closure activities showed evidence of remaining soil contamination and radioactive PSM. Future land use will be restricted from surface and intrusive activities. Closure activities generated waste streams consisting of industrial solid waste, recyclable materials, low-level radioactive waste, and mixed

Study on the development of safeguards information treatment system at the facility level

Energy Technology Data Exchange (ETDEWEB)

Lee, B. D.; Song, D. Y.; So, D. S.; Kwak, E. H. [KAERI, Taejon (Korea, Republic of)

2000-05-01

Safeguards Information Treatment System(SITS) at the facility level is required to implement efficiently the obligations under the Korea-IAEA Safeguards Agreement, bilateral agreements with other countries and domestic law. In this paper, the requirements and major functions of SITS were considered, and the error checking methods and the relationships of safeguards information were reviewed. SITS will be developed to cover the different accounting procedures and methods applied at the various facilities under IAEA safeguards. Also, the resolved result of the Y2K problem in the existing nuclear material accounting program was described.

Developing partnerships for implementing continental-scale citizen science programs at the local-level

Science.gov (United States)

Newman, S. J.; Henderson, S.; Ward, D.

2012-12-01

Project BudBurst is a citizen science project focused on monitoring plant phenology that resides at the National Ecological Observatory Network (NEON, Inc). A central question for Project BudBurst and other national outreach programs is: what are the most effective means of engaging and connecting with diverse communities throughout the country? How can continental scale programs like NEON's Project BudBurst engage audiences in such a way as to be relevant at both the local and continental scales? Staff with Project BudBurst pursued partnerships with several continental scale organizations: the National Wildlife Refuge System, the National Park Service, and botanic gardens to address these questions. The distributed nature of wildlife refuges, national parks, and botanic gardens around the country provided the opportunity to connect with participants locally while working with leadership at multiple scales. Project BudBurst staff talked with hundreds of staff and volunteers prior to setting a goal of obtaining and developing resources for several Refuge Partners, a pilot National Park partner, and an existing botanic garden partner during 2011. We were especially interested in learning best practices for future partnerships. The partnership efforts resulted in resource development for 12 Refuge partners, a pilot National Park partner, and 2 botanic garden partners. Early on, the importance of working with national level leaders to develop ownership of the partner program and input about resource needs became apparent. Once a framework for the partnership program was laid out, it became critical to work closely with staff and volunteers on the ground to ensure needs were met. In 2012 we began to develop an online assessment to allow our current and potential partners to provide feedback about whether or not the partnership program was meeting their needs and how the program could be improved. As the year progressed, the timeline for resource development became more

Developing a low-level radioactive waste disposal facility in Connecticut: Update on progress and new directions

Energy Technology Data Exchange (ETDEWEB)

Gingerich, R.E. [Connecticut Hazardous Waste Management Service, Hartford, CT (United States)

1993-03-01

Connecticut is a member of the Northeast Interstate Low-Level Radioactive Waste Management Compact (Northeast LLRW Compact). The other member of the Northeast LLRW Compact is New Jersey. The Northeast Interstate Low-Level Radioactive Waste Commission (Northeast Compact Commission), the Northeast LLRW Compact`s governing body, has designated both Connecticut and New Jersey as host states for disposal facilities. The Northeast Compact Commission has recommended that, for purposes of planning for each state`s facility, the siting agency for the state should use projected volumes and characteristics of the LLW generated in its own state. In 1987 Connecticut enacted legislation that assigns major responsibilities for developing a LLW disposal facility in Connecticut to the Connecticut Hazardous Waste Management Service (CHWMS). The CHWMS is required to: prepare and revise, as necessary, a LLW Management Plan for the state; select a site for a LLW disposal facility; select a disposal technology to be used at the site; select a firm to obtain the necessary approvals for the facility and to develop and operate it; and serve as the custodial agency for the facility. This paper discusses progress in developing a facility.

Development of an accelerated leach test(s) for low-level waste forms

International Nuclear Information System (INIS)

Dougherty, D.R.; Fuhrmann, M.; Colombo, P.

1985-01-01

An accelerated leach test(s) is being developed to predict long-term leaching behavior of low-level radioactive waste (LLW) forms in their disposal environments. As necessary background, a literature survey of reported leaching mechanisms, available mathematical models and factors that affect leaching of LLW forms has been compiled. Mechanisms which have been identified include diffusion, dissolution, ion exchange, corrosion and surface effects. A computerized data base of LLW leaching data and mathematical models is being developed. The data is being used for model evaluation by curve fitting and statistical analysis according to standard procedures of statistical quality control. Long-term leach tests on portland cement, bitumen and vinyl ester-styrene (VES) polymer waste forms are underway which are designed to identify and evaluate factors that accelerate leaching without changing the mechanisms. Initial results on the effect of temperature on leachability indicate that the leach rates of cement and VES waste forms increase with increasing temperature, whereas, the leach rate of bitumen is little affected. 10 refs., 5 figs

UNDERSTANDING IDEA OF CURRICULUM 2013 AND ITS CONSISTENCY ON DEVELOPING CURRICULUM DOCUMENT AT LEVEL OF EDUCATION UNIT (KTSP AT PRIMARY SCHOOL LEVEL

Directory of Open Access Journals (Sweden)

- Prihantini

2018-01-01

Full Text Available Abstract:. This study is based on various issues of Curriculum 2013, both in terms of teacher readiness to accept the Curriculum 2013, an understanding of the idea of Curriculum 2013, as well as in the implementation of teaching and learning. In the curriculum development theory, curriculum ideas are an important component that the curriculum development team needs to understand, so that the development of curriculum documents composed reflects continuity with curriculum ideas. The purpose of this study is to describe and explore the understanding of principals and teachers about the idea of Curriculum 2013 and its consistency on developing Education Unit Level Curriculum (KTSP at elementary school in Sukalarang sub-district, Sukabumi regency. The research method applied is qualitative research with descriptive exploratory approach. The conclusions of the study are: (1 the understanding of principals and teachers about the idea of the  Curriculum 2013 at the know stage, the understanding that curriculum ideas have consistency in the development of the Education Unit Level Curriculum (KTSP document is not yet owned; (2 the development of KTSP document shows no consistency between the idea of Curriculum 2013 with the documents of Book I KTSP, Book II KTSP, and Book III KTSP; (3 the problems faced by school principals and teachers in relation to the Curriculum 2013 is assessment of learning, both with regard to the techniques and types of assessment and techniques of administering the results of the assessment.Recommendations are proposed to policy makers that training strategies need to be changed from "theory oriented" to "practice oriented" and need to be varied in implementation at the Kecamatan or Cluster levels and enhanced effectiveness of curriculum counseling 2013. For principals and teachers expected to disseminate the 2013 Curriculum should be supported by presenting expert resources during the workshop, Principal Working Group (K3S and

Lower adiponectin levels at first trimester of pregnancy are associated with increased insulin resistance and higher risk of developing gestational diabetes mellitus.

Science.gov (United States)

Lacroix, Marilyn; Battista, Marie-Claude; Doyon, Myriam; Ménard, Julie; Ardilouze, Jean-Luc; Perron, Patrice; Hivert, Marie-France

2013-06-01

To evaluate the associations between adiponectin levels and 1) the risk of developing gestational diabetes mellitus (GDM), and 2) insulin resistance/sensitivity, β-cell function, and compensation indices in a prospective cohort representative of the general population of pregnant women. We performed anthropometric measurements and collected blood samples at 1st (6-13 weeks) and 2nd (24-28 weeks) trimesters. Diagnosis of GDM was made at 2nd trimester based on a 75-g oral glucose tolerance test (International Association of the Diabetes and Pregnancy Study Groups criteria). Insulin was measured (ELISA; Luminex) to estimate homeostasis model assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-B), insulin sensitivity (Matsuda index), insulin secretion (AUC(insulin/glucose)), and β-cell compensation (insulin secretion sensitivity index-2). Adiponectin was measured by radioimmunoassay. Among the 445 participants included in this study, 38 women developed GDM. Women who developed GDM had lower 1st-trimester adiponectin levels (9.67 ± 3.84 vs. 11.92 ± 4.59 µg/mL in women with normal glucose tolerance). Lower adiponectin levels were associated with higher risk of developing GDM (OR, 1.12 per 1 µg/mL decrease of adiponectin levels; P = 0.02, adjusted for BMI and HbA1c at 1st trimester). Adiponectin levels at 1st and 2nd trimesters were associated with HOMA-IR (both: r = -0.22, P insulin/glucose). Pregnant women with lower adiponectin levels at 1st trimester have higher levels of insulin resistance and are more likely to develop GDM independently of adiposity or glycemic measurements.

The Implementation Leadership Scale (ILS): development of a brief measure of unit level implementation leadership.

Science.gov (United States)

Aarons, Gregory A; Ehrhart, Mark G; Farahnak, Lauren R

2014-04-14

In healthcare and allied healthcare settings, leadership that supports effective implementation of evidenced-based practices (EBPs) is a critical concern. However, there are no empirically validated measures to assess implementation leadership. This paper describes the development, factor structure, and initial reliability and convergent and discriminant validity of a very brief measure of implementation leadership: the Implementation Leadership Scale (ILS). Participants were 459 mental health clinicians working in 93 different outpatient mental health programs in Southern California, USA. Initial item development was supported as part of a two United States National Institutes of Health (NIH) studies focused on developing implementation leadership training and implementation measure development. Clinician work group/team-level data were randomly assigned to be utilized for an exploratory factor analysis (n = 229; k = 46 teams) or for a confirmatory factor analysis (n = 230; k = 47 teams). The confirmatory factor analysis controlled for the multilevel, nested data structure. Reliability and validity analyses were then conducted with the full sample. The exploratory factor analysis resulted in a 12-item scale with four subscales representing proactive leadership, knowledgeable leadership, supportive leadership, and perseverant leadership. Confirmatory factor analysis supported an a priori higher order factor structure with subscales contributing to a single higher order implementation leadership factor. The scale demonstrated excellent internal consistency reliability as well as convergent and discriminant validity. The ILS is a brief and efficient measure of unit level leadership for EBP implementation. The availability of the ILS will allow researchers to assess strategic leadership for implementation in order to advance understanding of leadership as a predictor of organizational context for implementation. The ILS also holds promise as a tool for

The implementation leadership scale (ILS): development of a brief measure of unit level implementation leadership

Science.gov (United States)

2014-01-01

Background In healthcare and allied healthcare settings, leadership that supports effective implementation of evidenced-based practices (EBPs) is a critical concern. However, there are no empirically validated measures to assess implementation leadership. This paper describes the development, factor structure, and initial reliability and convergent and discriminant validity of a very brief measure of implementation leadership: the Implementation Leadership Scale (ILS). Methods Participants were 459 mental health clinicians working in 93 different outpatient mental health programs in Southern California, USA. Initial item development was supported as part of a two United States National Institutes of Health (NIH) studies focused on developing implementation leadership training and implementation measure development. Clinician work group/team-level data were randomly assigned to be utilized for an exploratory factor analysis (n = 229; k = 46 teams) or for a confirmatory factor analysis (n = 230; k = 47 teams). The confirmatory factor analysis controlled for the multilevel, nested data structure. Reliability and validity analyses were then conducted with the full sample. Results The exploratory factor analysis resulted in a 12-item scale with four subscales representing proactive leadership, knowledgeable leadership, supportive leadership, and perseverant leadership. Confirmatory factor analysis supported an a priori higher order factor structure with subscales contributing to a single higher order implementation leadership factor. The scale demonstrated excellent internal consistency reliability as well as convergent and discriminant validity. Conclusions The ILS is a brief and efficient measure of unit level leadership for EBP implementation. The availability of the ILS will allow researchers to assess strategic leadership for implementation in order to advance understanding of leadership as a predictor of organizational context for implementation

Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema

DEFF Research Database (Denmark)

Lassere, Marissa N; Johnson, Kent R; Boers, Maarten

2007-01-01

endpoints, and leading indicators, a quantitative surrogate validation schema was developed and subsequently evaluated at a stakeholder workshop. RESULTS: The search identified several classification schema and definitions. Components of these were incorporated into a new quantitative surrogate validation...... of the National Institutes of Health definitions of biomarker, surrogate endpoint, and clinical endpoint was useful. CONCLUSION: Further development and application of this schema provides incentives and guidance for effective biomarker and surrogate endpoint research, and more efficient drug discovery...... are then applied if there is serious counterevidence. A total score (0 to 15) determines the level of evidence, with Level 1 the strongest and Level 5 the weakest. It was proposed that the term "surrogate" be restricted to markers attaining Levels 1 or 2 only. Most stakeholders agreed that this operationalization...

Aircraft Maintenance Experience Design Handbook

Science.gov (United States)

1978-09-11

RlOM A JOB P iiLPAhATIL)N MINOR MAINTFNANCF DELAYS • ACCESS SF Fit L ING OUr FORMS FAL ISLAI11N ’ FAULT COIRNNCTION M4N[. FANCE 6 AOJUSIMUNT CALIBRATION...Washington , D).(. Auglsit. 19t4. "A*SC Dh 1-9, Maintainability (for Ground Electronics Syste.ms)", A1LS L _sigil handbook. Series -- 0. Gene •ai

DA POÉTICA DO ENGAJAMENTO NA LITERATURA POLICIAL DE LAURA LIPPMAN

Directory of Open Access Journals (Sweden)

Isabella Santos Mundim

2013-04-01

Full Text Available Este artigo propõe investigar como se dá a relação da literatura policial de Laura Lippman com um projeto ético determinado. Com base na leitura de obras selecionadas, pretende-se analisar como essa autora se vale da inventividade da linguagem para traduzir, em narrativa, o fenômeno da violência e a falência das instituições.

Calculated and Observed Speeds of Cavitation About Two- and Three- Dimensional Bodies in Water

Science.gov (United States)

1942-11-01

yE1l0.044po ellipse of - 36 (1 - Y) 6 0 .l.Olxx 0(y) L . 6.54 Porabolo Elipe em - Cicl Y ,11p f. 2 1 - fal: Figure 1 ScinofCylinders and Bodies of...Propellers,* by E.Z. Stowell and A.F. Deming , BACA Report 526, 1935. (2) "Flow about a Pair of Adjacent, Parallel Cylinders Normal to a Stream, Theoretical

Acute respiratory infection in children from developing nations: a multi-level study.

Science.gov (United States)

Pinzón-Rondón, Ángela María; Aguilera-Otalvaro, Paula; Zárate-Ardila, Carol; Hoyos-Martínez, Alfonso

2016-05-01

Worldwide, acute respiratory infections (ARI) are the leading cause of death of children under 5 years of age. To assess the accomplishment of the Millennium Development Goal on under-5 mortality particularly related to ARI in developing countries, and to explore the associations between country characteristics and ARI in children under 5 taking into account child, mother and household attributes. The study included a representative sample of 354,633 children under 5 years from 40 developing nations. A multilevel analysis of data from the Demographic and Health Surveys and the World Bank was conducted. The prevalence of ARI was 13%. Country inequalities were associated with the disease - GINI index (95% CI 1.01-1.04). The country's per capita gross domestic product (GDP) (95% CI 1.00-1.01) and health expenditure (95% CI 1.01-1.01) affected the relationship between immunization and ARI, while inequalities influenced the relationship between household wealth (95% CI 0.99-0.99) and the disease. Other factors positively associated with ARI were male gender, low birthweight, working mothers and a high-risk indoor environment. Factors associated with ARI reduction were older children, immunization, breastfeeding for more than 6 months, older maternal age, maternal education and planned pregnancy. In developing countries, public health campaigns to target ARI should consider the country's macro characteristics. At country level, inequalities but not health expenditure or GDP were associated with the disease and were independent of child, family and household characteristics. The effect of immunization on reducing ARI is greater in countries with a higher GDP and health expenditure. The effect of household wealth on ARI is less in countries with fewer inequalities. Reduction of inequalities is an important measure to decrease ARI in developing countries.

CURRICULUM POLICY MAKERS PERCEPTIONS OF CURRICULUM DEVELOPMENT PROCESS BASED ON SOLO TAXONOMY IN SECONDARY LEVEL SCHOOLS IN SRI LANKA

OpenAIRE

P. H. Kusumawathie; Norhisham Mohamad; Ferdous Azam

2017-01-01

Purpose: The purpose of this study is to explore the conceptual awareness of curriculum policy makers on curriculum development process based on SOLO Taxonomy curriculum approach in secondary level schools. Further, the study explored the relationship between the curriculum development inputs and the SOLO based curriculum development process. The curriculum development inputs are teacher effectiveness, school community, school environment and technology availability. Method: Data was collecte...

Eficácia na utilização de córneas no transplante penetrante

Directory of Open Access Journals (Sweden)

Ghanem Vinícius Coral

2003-01-01

Full Text Available OBJETIVOS: 1 Verificar qual o impacto da criação do Cadastro Técnico Único (CTU para o Hospital das Clínicas da Universidade de Campinas (Unicamp no tempo de preservação de córneas utilizadas em transplantes penetrantes eletivos, e 2 comparar a incidência de falência primária em transplantes penetrantes de córnea nos períodos pré e pós-criação do CTU. MÉTODOS: Foi realizado estudo retrospectivo no Hospital de Clínicas da Unicamp, avaliando-se 15 transplantes penetrantes de córnea consecutivos entre 1 de janeiro e 30 de abril de 2000 e 24 transplantes consecutivos entre 1 de maio e 20 de setembro de 2000 (córneas sob o controle do Cadastro Técnico Único, num total de 39 transplantes. RESULTADOS: O tempo médio entre a preparação das córneas e o transplante foi de 3,8 dias (±1,78 no período pré-CTU, e de 6,0 dias (±2,97 no período pós-CTU, representando aumento no tempo de preservação de 36,7%. Houve diferença estatisticamente significativa (p=0,02 entre os dois grupos. Nenhum caso de falência primária do enxerto foi observado entre os 39 pacientes transplantados nos dois grupos. CONCLUSÃO: Com base nestes resultados, conclui-se que a nova disposição do Sistema Estadual de Transplantes aumentou de forma estatisticamente significativa o período de permanência das córneas no meio de preservação, o que pode comprometer o tempo de vida útil do transplante, aumentar a incidência de falência primária ou levar a maior número de córneas perdidas por excederem o tempo de preservação limite, preconizado na literatura.

Development of safeguards information treatment system at facility level in Korea

International Nuclear Information System (INIS)

So, D.S.; Lee, B.D.; Song, D.Y.

2001-01-01

Safeguards Information Treatment System (SITS) at Facility level was developed to implement efficiently the obligations under IAEA comprehensive Safeguards Agreement, bilateral nuclear cooperation Agreements with other countries and domestic law, and to manage efficiently the information related to safeguards implementation at facility level in Korea. Nuclear facilities in Korea are categorized into 8 types based on its accounting characteristics as follows: (1) Item counting facility or bulk handling facility; (2) Batch follow-up facility or not; (3) MUF (Material Unaccounted For) occurrence or not; (4) Nuclear production facility or not; (5) Operation status of facility; (6) Information management of nuclear material transfer status between KMPs or not; (7) Indication of inventory KMP on the inventory change of nuclear material is required or not. Hardware and Software for SITS can be loaded on a personal computer under operation system of Window 2000 or Window NT. MS SQL server 7 and MS Internet Information Server were adopted for database management system and Web server, respectively. Network environment of SITS was designed to include nuclear research institute, nuclear power plants of PWR and CANDU, nuclear fuel fabrication facilities and other facilities. SITS can be operated standalone or under the client-server system if intranet exists. More detailed contents of SITS are described elsewhere. Each module of SITS will be tested during incorporation of existing data into SITS and SITS will be distributed to nuclear facilities in Korea

Relationship between serum leptin levels, ATPase activity of erythrocyte membrance and development of diabetic nephropathy in patients with DM2

International Nuclear Information System (INIS)

Wang Yuming