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Sample records for level-2 milestone id

  1. Age-aware solder performance models : level 2 milestone completion.

    Energy Technology Data Exchange (ETDEWEB)

    Neilsen, Michael K.; Vianco, Paul Thomas; Neidigk, Matthew Aaron; Holm, Elizabeth Ann

    2010-09-01

    Legislated requirements and industry standards are replacing eutectic lead-tin (Pb-Sn) solders with lead-free (Pb-free) solders in future component designs and in replacements and retrofits. Since Pb-free solders have not yet seen service for long periods, their long-term behavior is poorly characterized. Because understanding the reliability of Pb-free solders is critical to supporting the next generation of circuit board designs, it is imperative that we develop, validate and exercise a solder lifetime model that can capture the thermomechanical response of Pb-free solder joints in stockpile components. To this end, an ASC Level 2 milestone was identified for fiscal year 2010: Milestone 3605: Utilize experimentally validated constitutive model for lead-free solder to simulate aging and reliability of solder joints in stockpile components. This report documents the completion of this milestone, including evidence that the milestone completion criteria were met and a summary of the milestone Program Review.

  2. Level-2 Milestone 5213. CTS-1 Contract Award Completed

    Energy Technology Data Exchange (ETDEWEB)

    Leininger, Matt [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-09-24

    This report documents the fact that the first commodity technology (CT) system contract award, CTS-1, has been completed. The description of the milestone is: Based on Tri-Lab CTS-1 process and review, LLNL successfully awards the procurement for the next-generation Tri-Lab Linux CTS-1. The milestone completion criterion is: Signed contract. The milestone was completed on September 24th. 2015.

  3. Milestone Report - Level-2 Milestone 5589: Modernization and Expansion of LLNL Archive Disk Cache

    Energy Technology Data Exchange (ETDEWEB)

    Shoopman, J. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-02-04

    This report documents Livermore Computing (LC) activities in support of ASC L2 milestone 5589: Modernization and Expansion of LLNL Archive Disk Cache, due March 31, 2016. The full text of the milestone is included in Attachment 1. The description of the milestone is: Description: Configuration of archival disk cache systems will be modernized to reduce fragmentation, and new, higher capacity disk subsystems will be deployed. This will enhance archival disk cache capability for ASC archive users, enabling files written to the archives to remain resident on disk for many (6–12) months, regardless of file size. The milestone was completed in three phases. On August 26, 2015 subsystems with 6PB of disk cache were deployed for production use in LLNL’s unclassified HPSS environment. Following that, on September 23, 2015 subsystems with 9 PB of disk cache were deployed for production use in LLNL’s classified HPSS environment. On January 31, 2016, the milestone was fully satisfied when the legacy Data Direct Networks (DDN) archive disk cache subsystems were fully retired from production use in both LLNL’s unclassified and classified HPSS environments, and only the newly deployed systems were in use.

  4. Campaign 2 Level 2 Milestone Review 2009: Milestone # 3131 Grain Scale Simulation of Pore Collapse

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, A J

    2009-09-28

    The milestone reviewed on Sept. 16, 2009 was 'High-fidelity simulation of shock initiation of high explosives at the grain scale using coupled hydrodynamics, thermal transport and chemistry'. It is the opinion of the committee that the team has satisfied the milestone. A detailed description of how the goals were met is provided. The milestone leveraged capabilities from ASC Physics and Engineering Materials program combined with experimental input from Campaign 2. A combined experimental-multiscale simulation approach was used to create and validate the various TATB model components. At the lowest length scale, quantum chemical calculations were used to determine equations of state, thermal transport properties and reaction rates for TATB as it is decomposing. High-pressure experiments conducted in diamond anvil cells, gas guns and the Z machine were used to validate the EOS, thermal conductivity, specific heat and predictions of water formation. The predicted reaction networks and chemical kinetic equations were implemented in Cheetah and validated against the lower length scale data. Cheetah was then used within the ASC code ALE3D for high-resolution, thermo-mechanically coupled simulations of pore collapse at the micron size scale to predict conditions for detonation initiation.

  5. Planning for Pre-Exascale Platform Environment (Fiscal Year 2015 Level 2 Milestone 5216)

    Energy Technology Data Exchange (ETDEWEB)

    Springmeyer, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lang, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Noe, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-09-28

    This Plan for ASC Pre-Exascale Platform Environments document constitutes the deliverable for the fiscal year 2015 (FY15) Advanced Simulation and Computing (ASC) Program Level 2 milestone Planning for Pre-Exascale Platform Environment. It acknowledges and quantifies challenges and recognized gaps for moving the ASC Program towards effective use of exascale platforms and recommends strategies to address these gaps. This document also presents an update to the concerns, strategies, and plans presented in the FY08 predecessor document that dealt with the upcoming (at the time) petascale high performance computing (HPC) platforms. With the looming push towards exascale systems, a review of the earlier document was appropriate in light of the myriad architectural choices currently under consideration. The ASC Program believes the platforms to be fielded in the 2020s will be fundamentally different systems that stress ASC’s ability to modify codes to take full advantage of new or unique features. In addition, the scale of components will increase the difficulty of maintaining an errorfree system, thus driving new approaches to resilience and error detection/correction. The code revamps of the past, from serial- to vector-centric code to distributed memory to threaded implementations, will be revisited as codes adapt to a new message passing interface (MPI) plus “x” or more advanced and dynamic programming models based on architectural specifics. Development efforts are already underway in some cases, and more difficult or uncertain aspects of the new architectures will require research and analysis that may inform future directions for program choices. In addition, the potential diversity of system architectures may require parallel if not duplicative efforts to analyze and modify environments, codes, subsystems, libraries, debugging tools, and performance analysis techniques as well as exploring new monitoring methodologies. It is difficult if not impossible to

  6. ASC Tri-lab Co-design Level 2 Milestone Report 2015

    Energy Technology Data Exchange (ETDEWEB)

    Hornung, Rich [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Jones, Holger [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Keasler, Jeff [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Neely, Rob [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pearce, Olga [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hammond, Si [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trott, Christian [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Paul [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vaughan, Courtenay [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Jeanine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoekstra, Rob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bergen, Ben [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Payne, Josh [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Womeldorff, Geoff [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-23

    In 2015, the three Department of Energy (DOE) National Laboratories that make up the Advanced Sci- enti c Computing (ASC) Program (Sandia, Lawrence Livermore, and Los Alamos) collaboratively explored performance portability programming environments in the context of several ASC co-design proxy applica- tions as part of a tri-lab L2 milestone executed by the co-design teams at each laboratory. The programming environments that were studied included Kokkos (developed at Sandia), RAJA (LLNL), and Legion (Stan- ford University). The proxy apps studied included: miniAero, LULESH, CoMD, Kripke, and SNAP. These programming models and proxy-apps are described herein. Each lab focused on a particular combination of abstractions and proxy apps, with the goal of assessing performance portability using those. Performance portability was determined by: a) the ability to run a single application source code on multiple advanced architectures, b) comparing runtime performance between \

  7. Level-2 Milestone 5588: Deliver Strategic Plan and Initial Scalability Assessment by Advanced Architecture and Portability Specialists Team

    Energy Technology Data Exchange (ETDEWEB)

    Draeger, Erik W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-09-30

    This report documents the fact that the work in creating a strategic plan and beginning customer engagements has been completed. The description of milestone is: The newly formed advanced architecture and portability specialists (AAPS) team will develop a strategic plan to meet the goals of 1) sharing knowledge and experience with code teams to ensure that ASC codes run well on new architectures, and 2) supplying skilled computational scientists to put the strategy into practice. The plan will be delivered to ASC management in the first quarter. By the fourth quarter, the team will identify their first customers within PEM and IC, perform an initial assessment and scalability and performance bottleneck for next-generation architectures, and embed AAPS team members with customer code teams to assist with initial portability development within standalone kernels or proxy applications.

  8. FITARA Milestones

    Data.gov (United States)

    Social Security Administration — Fulfills OMB's requirement to submit an update on progress of actions/milestones that were listed in SSA's FITARA Implementation Plan. This JSON file allows OMB to...

  9. Pathology Milestones

    Directory of Open Access Journals (Sweden)

    J. Stacey Klutts MD, PhD

    2015-10-01

    Full Text Available All Accreditation Council for Graduate Medical Education accredited pathology residency training programs are now required to evaluate residents using the new Pathology Milestones assessment tool. Similar to implementation of the 6 Accreditation Council for Graduate Medical Education competencies a decade ago, there have been challenges in implementation of the new milestones for many residency programs. The pathology department at the University of Iowa has implemented a process that divides the labor of the task in rating residents while also maintaining consistency in the process. The process is described in detail, and some initial trends in milestone evaluation are described and discussed. Our experience indicates that thoughtful implementation of the Pathology Milestones can provide programs with valuable information that can inform curricular changes.

  10. Milestones of general relativity

    Science.gov (United States)

    Pullin, Jorge

    2017-02-01

    We present a summary for non-specialists of the special issue of the journal Classical and Quantum Gravity on ‘Milestones of general relativity’, commemorating the 100th anniversary of the theory.

  11. The ADMSEP Milestones Project.

    Science.gov (United States)

    Roman, Brenda; Schatte, Dawnelle; Frank, Julia; Brouette, Thomas; Brand, Michael; Talley, Brenda; Ramchandani, Dilip; Lewis, Catherine; Blazek, Mary; Carlson, David; Smith, Mary Kay

    2016-04-01

    Credentialing bodies mandate that a medical school's curriculum be based upon recognized guidelines. Within the field of psychiatry, the Association of Directors of Medical Student Education in Psychiatry (ADMSEP) has previously published recommended guidelines for the pre-clinical and clerkship curriculum. Ongoing changes within the Liaison Committee on Medical Education's requirements for medical school curricula, and the publication of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition, necessitated review of these guidelines. ADMSEP convened a task force of psychiatric educators to develop a consensus report outlining new guidelines. The ADMSEP membership reviewed and approved this final document. The guidelines outline six core learning objectives with corresponding competencies. Each of these competencies specifies accompanying milestones to be achieved through the course of medical school. ADMSEP believes these guidelines will aid educators in crafting a school's psychiatric curriculum. Clearly articulated milestones may foster the further development of validated educational and assessment tools by ADMSEP and other organizations.

  12. A Heavy Milestone

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Changes to China’s employment law have proved controversial,pitting pro-labor against pro-employer After more than two years of deliber- ation and public comments,the Law of the People’s Republic of China on Employment Contracts, or Employment Contract Law,has been ratified and will officially come into force on January 1,2008.What does the new law imply for employers and employees? The new law is a milestone in building an employment and social security system in China since the current Employment Law of China was enacted in 1994.It has been for- mulated to protect the lawful rights and inter-

  13. Milestones in welding technology

    Science.gov (United States)

    Dolby, Richard E.

    2013-09-01

    Sir Alan's PhD thesis describes his research into cracking during arc welding of armour steels. Throughout his career, he had a strong interest in defects of all types, how they formed in metallic structures and how the larger ones could be detected and sized by non-destructive techniques. He was also vitally concerned with how defects impacted on the engineering integrity of welded structures, particularly the risk of fracture in nuclear plant. This study presents a view of some of the major milestones in global welding technology that took place over the 60 or more years of Sir Alan's career and highlights those where he had a personal and direct involvement.

  14. Milestones in ataxia

    Science.gov (United States)

    Klockgether, Thomas; Paulson, Henry

    2010-01-01

    The past 25 years have seen enormous progress in the deciphering of the genetic and molecular basis of ataxias resulting in an improved understanding of their pathogenesis. The most significant milestones during this period were the cloning of the genes associated with the common spinocerebellar ataxias (SCAs), ataxia telangiectasia (AT) and Friedreich ataxia (FRDA). To date, the causative mutations of more than 30 SCAs and 20 recessive ataxias have been identified. In addition, there are numerous acquired ataxias with defined molecular causes so that the entire number of distinct ataxia disorders exceeds 50 and possibly approaches 100. Despite this enormous heterogeneity, a few recurrent pathopyhsiological themes stand out. These include protein aggregation, failure of protein homoestasis, perturbations in ion channel function, defects in DNA repair and mitochondrial dysfunction. The clinical phenotypes of the most common ataxia disorders have been firmly established, and their natural history is being studied in ongoing large observational trials. Effective therapies for ataxias are still lacking. However, novel drug targets are under investigation, and it is expected that there will be an increasing number of therapeutic trials in ataxia. PMID:21626557

  15. TRT Barrel milestones passed

    CERN Multimedia

    Ogren, H

    2004-01-01

    The barrel TRT detector passed three significant milestones this spring. The Barrel Support Structure (BSS) was completed and moved to the SR-1 building on February 24th. On March 12th the first module passed the quality assurance testing in Building 154 and was transported to the assembly site in the SR-1 building for barrel assembly. Then on April 21st the final production module that had been scanned at Hampton University was shipped to CERN. TRT Barrel Module Production The production of the full complement of barrel modules (96 plus 9 total spares) is now complete. This has been a five-year effort by Duke University, Hampton University, and Indiana University. Actual construction of the modules in the United States was completed in the first part of 2004. The production crews at each of the sites in the United States have now completed their missions. They are shown in the following pictures. Duke University: Production crew with the final completed module. Indiana University: Module producti...

  16. A milestone in safety

    CERN Multimedia

    2010-01-01

    Over recent days, we’ve achieved some historic milestones in LHC physics as we’ve made the transition from proton to ion running. These have been widely reported and I’ve communicated the news to you by e-mail. Less visible, but nonetheless vital to the functioning of the Lab, is an agreement that we’ll be signing with our Host States on 15 November. It will be the second tripartite agreement to be signed in as many months, and it is set to streamline our radiation protection and radiation safety.   The new agreement replaces existing bilateral agreements governing the procedures applying on the French and Swiss parts of the site. From an operational point of view, the new agreement simplifies matters by harmonising administrative processes while guaranteeing best practice in terms of radiation protection and radiation safety at CERN. The agreement is the result of many months of detailed discussions with the Autorité de Sûret&eac...

  17. Purdue, UCSD achieve networking milestones

    CERN Document Server

    Kapp, Jennifer

    2006-01-01

    "Purdue University researchers have reached new milestones in Grid interoperability through the successful integration of two Open Science Grid (OSG) sites running a scientific application over the National Science Foundation TeraGrid network." (1,5 page)

  18. Fragrance Chemistry Milestones and Perspectives

    National Research Council Canada - National Science Library

    Gautschi, Markus; Bajgrowicz, Jerzy A; Kraft, Philip

    2001-01-01

    This mini-review on Fragrance Chemistry focuses on milestones in the timelines of musk, ionone/ woody and sandalwood odorants, as well as on new perspectives arising from the development of fragrance precursors...

  19. FY14 Codesign Milestone Summary

    Energy Technology Data Exchange (ETDEWEB)

    Hoekstra, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Barrett, Richard Frederick [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Howell, Louis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Daniel, David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    This milestone was the 2nd in a series of Tri-Lab Co-Design L2 milestones supporting ‘Co-Design’ efforts in the ASC program. It is a crucial step towards evaluating the effectiveness of proxy applications in exploring code performance on next generation architectures. All three labs evaluated the performance of 2 proxy applications on modern architectures and/or testbeds for pre-production hardware. The results are captured in this document as well as annotated presentations from all 3 laboratories.

  20. Implementation of nephrology subspecialty curricular milestones.

    Science.gov (United States)

    Yuan, Christina M; Prince, Lisa K; Oliver, James D; Abbott, Kevin C; Nee, Robert

    2015-07-01

    Beginning in the 2014-2015 training year, the US Accreditation Council for Graduate Medical Education (ACGME) required that nephrology Clinical Competency Committees assess fellows' progress toward 23 subcompetency "context nonspecific" internal medicine subspecialty milestones. Fellows' advancement toward the "ready for unsupervised practice" target milestone now is tracked in each of the 6 competencies: Patient Care, Medical Knowledge, Professionalism, Interpersonal Communication Skills, Practice-Based Learning and Improvement, and Systems-Based Practice. Nephrology program directors and subspecialty societies must define nephrology-specific "curricular milestones," mapped to the nonspecific ACGME milestones. Although the ACGME goal is to produce data that can discriminate between successful and underperforming training programs, the approach is at risk to produce biased, inaccurate, and unhelpful information. We map the ACGME internal medicine subspecialty milestones to our previously published nephrology-specific milestone schema and describe entrustable professional activities and other objective assessment tools that inform milestone decisions. Mapping our schema onto the ACGME subspecialty milestone reporting form allows comparison with the ACGME subspecialty milestones and the curricular milestones developed by the American Society of Nephrology Program Directors. Clinical Competency Committees may easily adapt and directly translate milestone decisions reached using our schema onto the ACGME internal medicine subspecialty competency milestone-reporting format.

  1. CMS silicon tracker milestone 200

    CERN Document Server

    Dierlamm, A

    2002-01-01

    The tracker of CMS will fully consist of silicon micro-strip and pixel sensors. Building a detector with 210 m/sup 2/ sensor surface in about 3 years requires a tightly controlled construction schedule. All different aspects of the production are exercised within a pre- production of 200 modules (Milestone 200) to identify and eliminate possible bottlenecks and to test the complete electronic chain. The quality, process stability and radiation hardness of the silicon sensors will be permanently monitored. Automatic assembly procedure and industrial bonding machines will guarantee a fast and reliable construction. All modules will be tested for signal, noise and pedestals at room temperature and operation temperature of -10 degrees C. Quality assurance of the Milestone 200 sensors and modules including irradiation and stability tests are presented. (6 refs).

  2. SecurID

    CERN Document Server

    Now called RSA SecurID, SecurID is a mechanism developed by Security Dynamics that allows two-factor authentication for a user on a network resource. It works on the principle of the unique password mode, based on a shared secret. Every sixty seconds, the component generates a new six-digit token on the screen. The latter comes from the current time (internal clock) and the seed (SecurID private key that is available on the component, and is also from the SecurID server). During an authentication request, the SecurID server will check the entered token by performing exactly the same calculation as that performed by your component. The server knows the two information required for this calculation: the current time and the seed of your component. Access is allowed if the token calculated by the server matches the token you specified.

  3. ASDS Cosmetic Dermatologic Surgery Fellowship Milestones.

    Science.gov (United States)

    Waldman, Abigail; Arndt, Kenneth A; Avram, Mathew M; Brown, Mariah R; Dover, Jeffrey S; Fabi, Sabrina G; Friedmann, Daniel P; Geronemus, Roy G; Goldberg, David J; Goldman, Mitchel P; Green, Jeremy B; Ibrahimi, Omar A; Jones, Derek H; Kilmer, Suzanne L; McDaniel, David H; Obagi, Suzan; Ortiz, Arisa E; Rohrer, Thomas E; Taylor, Mark B; Torres, Abel; Weinkle, Susan H; Weiss, Margaret A; Weiss, Eduardo T; Weiss, Robert A; Poon, Emily; Alam, Murad

    2016-10-01

    The American Council of Graduate Medical Education, which oversees much of postgraduate medical education in the United States, has championed the concept of "milestones," standard levels of achievement keyed to particular time points, to assess trainee performance during residency. To develop a milestones document for the American Society for Dermatologic Surgery (ASDS) Cosmetic Dermatologic Surgery (CDS) fellowship program. An ad hoc milestone drafting committee was convened that included members of the ASDS Accreditation Work Group and program directors of ASDS-approved Cosmetic Dermatologic Surgery (CDC) fellowship training programs. Draft milestones were circulated through email in multiple rounds until consensus was achieved. Thirteen milestones were developed in the 6 Accreditation Council for Graduate Medical Education (ACGME) competency areas, with 8 of these being patient-care milestones. Additional instructions for milestone administration more specific to the CDS fellowship than general ACGME instructions were also approved. Implementation of semiannual milestones was scheduled for the fellowship class entering in July 2018. Milestones are now available for CDS fellowship directors to implement in combination with other tools for fellow evaluation.

  4. A Mathematical Theory of Optimal Milestoning (with a Detour via Exact Milestoning)

    CERN Document Server

    Lin, Ling; Vanden-Eijnden, Eric

    2016-01-01

    Milestoning is a computational procedure that reduces the dynamics of complex systems to memoryless jumps between intermediates, or milestones, and only retains some information about the probability of these jumps and the time lags between them. Here we analyze a variant of this procedure, termed optimal milestoning, which relies on a specific choice of milestones to capture exactly some kinetic features of the original dynamical system. In particular, we prove that optimal milestoning permits the exact calculation of the mean first passage times (MFPT) between any two milestones. In so doing, we also analyze another variant of the method, called exact milestoning, which also permits the exact calculation of certain MFPTs, but at the price of retaining more information about the original system's dynamics. Finally, we discuss importance sampling strategies based on optimal and exact milestoning that can be used to bypass the simulation of the original system when estimating the statistical quantities used in...

  5. Tilecal meets two major milestones

    CERN Multimedia

    Cavalli-Sforza, M.

    Over the last two months the Tile Calorimeter passed not one but two major milestones. In early May, the last of the 64 modules that make up one of the two Extended Barrels arrived at CERN from IFAE-Barcelona, equipped with optical components and tested. And during the Overview Week in Clermont-Ferrand, the last of the 64 Barrel modules, mechanically assembled, arrived from JINR-Dubna. Just a brief reminder: the ATLAS Tile Calorimeter is composed of 3 cylinders ("barrels") of steel, scintillating tiles and optical fibers, altogether about 12 m long, with an outer diameter of 8.4 m, and weighing about 2700 tons. The central cavity will contain the Liquid Argon cryostats, and the whole calorimetry system will measure the direction and energy of jets produced at the LHC, as well as the missing transverse energy, which as everyone knows is one of the telltale signals of new and exciting physics. Each of the three cylinders is divided azimuthally into 64 modules - much like the slices of an orange. The modules ar...

  6. CERN receives prestigious Milestone recognition from IEEE

    CERN Multimedia

    2005-01-01

    At a ceremony at CERN, Mr W. Cleon Anderson, President of the Institute of Electrical and Electronics Engineers (IEEE) formally a Milestone plaque in recognition of the invention of electronic particle detectors at CERN

  7. CERN receives prestigious Milestone recognition from IEEE

    CERN Multimedia

    2005-01-01

    The Nobel prize winner Georges Charpak and W. Cleon Anderson, IEEE President, unveil the Milestone bronze plaques. At a ceremony on 26 September at the Globe of Science and Innovation, Mr W. Cleon Anderson, President of the Institute of Electrical and Electronics Engineers (IEEE) formally dedicated Milestone plaques recognising the invention of electronic particle detectors at CERN. The plaque were unveiled by Mr Anderson and Georges Charpak, the Nobel-prize winning inventor of wire chamber technology at CERN in 1968. The IEEE is the world's largest professional association dedicated to the advancement of technology with 365,000 individual members in over 150 countries. Established in 1983, there are currently over 60 Milestones around the world. They honour momentous achievements in the history of electrical and electronics engineering, such as the landing of the first transatlantic cable, code breaking at Bletchley Park during World War II, and the development of the Japanese Bullet train, the Tokaido Shin...

  8. Successful I.D. Encounters.

    Science.gov (United States)

    Poorman, Margaret J.

    Instructional Development (I.D.) encounters are dependent for success on such variables as power, politics, promotion, and organizational placement. I.D. consultants must be aware of power bases or orientation of other personnel and clients, e.g., these four "power personalities" which affect their efforts in managing I.D. encounters: the gate…

  9. The IEEE Milestone event at CERN

    CERN Multimedia

    2005-01-01

    On the initiative of its French and Swiss Sections, the IEEE has honoured CERN with an 'IEEE Milestone in the history of electricity and electronics' for the invention of the multi-wire proportional chamber in 1968. The IEEE established the Electrical Engineering Milestones programe in 1983 to honour significant achievements in the history of electrical and electronics engineering. To be designated, an achievement must be at least 25 years old, must have involved a unique solution to an engineering problem, and must have had at least regional impact. Currently there are more than  50 IEEE Milestones around the world. http://www.ieee.org/organizations/history_center/cern.html The installation and unveiling of this IEEE Milestone will provide the opportunity to emphasize the close relationship between science, technology, industry and well-being in society.  A ceremony, organised with the support of a group of IEEE members working at CERN, will be held at the CERN Globe of Science and Inn...

  10. Milestones Toward Majorana-Based Quantum Computing

    Science.gov (United States)

    Aasen, David; Hell, Michael; Mishmash, Ryan V.; Higginbotham, Andrew; Danon, Jeroen; Leijnse, Martin; Jespersen, Thomas S.; Folk, Joshua A.; Marcus, Charles M.; Flensberg, Karsten; Alicea, Jason

    2016-07-01

    We introduce a scheme for preparation, manipulation, and read out of Majorana zero modes in semiconducting wires with mesoscopic superconducting islands. Our approach synthesizes recent advances in materials growth with tools commonly used in quantum-dot experiments, including gate control of tunnel barriers and Coulomb effects, charge sensing, and charge pumping. We outline a sequence of milestones interpolating between zero-mode detection and quantum computing that includes (1) detection of fusion rules for non-Abelian anyons using either proximal charge sensors or pumped current, (2) validation of a prototype topological qubit, and (3) demonstration of non-Abelian statistics by braiding in a branched geometry. The first two milestones require only a single wire with two islands, and additionally enable sensitive measurements of the system's excitation gap, quasiparticle poisoning rates, residual Majorana zero-mode splittings, and topological-qubit coherence times. These pre-braiding experiments can be adapted to other manipulation and read out schemes as well.

  11. GOCE level 2 gravity gradients

    NARCIS (Netherlands)

    Bouman, J.; Fiorot, S.; Fuchs, M.; Gruber, T.; Schrama, E.J.O.; Tscherning, C.C.; Veicherts, M.; Visser, P.N.A.M.

    2011-01-01

    Two of the GOCE Level 2 products are the gravity gradients (GGs) in the Gradiometer Reference Frame (GRF) and the GGs in the Local North-Oriented Frame (LNOF). The GRF is an instrument frame and the GGs are derived from the L1b GGs. The L1b to L2 GG processing involves corrections for temporal gravi

  12. A MILESTONE IN CROSS-STRAITS RELATIONS

    Institute of Scientific and Technical Information of China (English)

    DENG YUNGUANG; DING XING

    2010-01-01

    @@ Chongqing, the southwestern municipality that served as China's capital during World War Ⅱ, will be remembered again for hosting a landmark event in the Chinese history on June 29. On that day, Chen Yunlin,President of the mainland's Association for Relations Across the Taiwan Straits,and Chiang Pin-kung, Chairman of Taiwan's Straits Exchange Foundation,signed the long-awaited Economic Cooperation Framework Agreement (ECFA) in Chongqing, a move hailed by many as a milestone in cross-Straits relations.

  13. Internal Medicine Residents' Perspectives on Receiving Feedback in Milestone Format.

    Science.gov (United States)

    Angus, Steven; Moriarty, John; Nardino, Robert J; Chmielewski, Amy; Rosenblum, Michael J

    2015-06-01

    In contrast to historical feedback, which was vague or provided residents' numerical scores without clear meaning, milestone-based feedback is focused on specific knowledge, skills, and behaviors that define developmental trajectory. It was anticipated that residents would welcome the more specific and actionable feedback provided by the milestone framework, but this has not been studied. We assessed internal medicine (IM) residents' perceptions of receiving feedback in the milestone framework, particularly assessing perception of the utility of milestone-based feedback compared to non-milestone-based feedback. We surveyed a total of 510 IM residents from 7 institutions. Survey questions assessed resident perception of milestone feedback in identifying strengths, weaknesses, and trajectory of professional development. Postgraduate years 2 and 3 (PGY-2 and PGY-3) residents were asked to compare milestones with prior methods of feedback. Of 510 residents, 356 (69.8%) responded. Slightly less than half of the residents found milestone-based feedback "extremely useful" or "very useful" in identifying strengths (44%), weaknesses (43%), specific areas for improvement (45%), and appropriate education progress (48%). Few residents found such feedback "not very useful" or "not at all useful" in these domains. A total of 51% of PGY-2 and PGY-3 residents agreed that receiving milestone-based feedback was more helpful than previous forms of feedback. IM residents are aware of the concepts of milestones, and half of the residents surveyed found milestone feedback more helpful than previous forms of feedback. More work needs to be done to understand how milestone-based feedback could be delivered more effectively to enhance resident development.

  14. Post-processing V&V level II ASC milestone (2360) results.

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, Elmer; Karelitz, David B.; Brunner, Thomas A.; Trucano, Timothy Guy; Moreland, Kenneth D.; Weirs, V. Gregory; Shead, Timothy M.

    2007-09-01

    The 9/30/2007 ASC Level 2 Post-Processing V&V Milestone (Milestone 2360) contains functionality required by the user community for certain verification and validation tasks. These capabilities include loading of edge and face data on an Exodus mesh, run-time computation of an exact solution to a verification problem, delivery of results data from the server to the client, computation of an integral-based error metric, simultaneous loading of simulation and test data, and comparison of that data using visual and quantitative methods. The capabilities were tested extensively by performing a typical ALEGRA HEDP verification task. In addition, a number of stretch criteria were met including completion of a verification task on a 13 million element mesh.

  15. Milestones Toward Majorana-Based Quantum Computing

    Directory of Open Access Journals (Sweden)

    David Aasen

    2016-08-01

    Full Text Available We introduce a scheme for preparation, manipulation, and read out of Majorana zero modes in semiconducting wires with mesoscopic superconducting islands. Our approach synthesizes recent advances in materials growth with tools commonly used in quantum-dot experiments, including gate control of tunnel barriers and Coulomb effects, charge sensing, and charge pumping. We outline a sequence of milestones interpolating between zero-mode detection and quantum computing that includes (1 detection of fusion rules for non-Abelian anyons using either proximal charge sensors or pumped current, (2 validation of a prototype topological qubit, and (3 demonstration of non-Abelian statistics by braiding in a branched geometry. The first two milestones require only a single wire with two islands, and additionally enable sensitive measurements of the system’s excitation gap, quasiparticle poisoning rates, residual Majorana zero-mode splittings, and topological-qubit coherence times. These pre-braiding experiments can be adapted to other manipulation and read out schemes as well.

  16. Infant developmental milestones and adult intelligence

    DEFF Research Database (Denmark)

    Flensborg-Madsen, Trine; Mortensen, Erik Lykke

    2015-01-01

    Background: A number of studies suggest a positive association between faster infant motor development and intellectual function in childhood and adolescence. However, studies investigating the relationship between infant motor development and intelligence in adulthood are lacking. Aims: To inves......Background: A number of studies suggest a positive association between faster infant motor development and intellectual function in childhood and adolescence. However, studies investigating the relationship between infant motor development and intelligence in adulthood are lacking. Aims......: To investigate whether age at achievement of 12 motor developmental milestones was associated with adult intelligence and to evaluate the influence of sex, parental social status, parity,mother's cigarette consumption in the last trimester, gestational age, birthweight, and birth length on this association....... Methods: Mothers of 9125 children of the Copenhagen Perinatal Cohort recorded 12 developmental milestones during the child's first year of life. A subsample of the cohort comprising 1155 individuals participated in a follow-up when they were aged 20–34 years and were administered the Wechsler Adult...

  17. Found in transition: applying milestones to three unique discharge curricula

    Directory of Open Access Journals (Sweden)

    Lauren B. Meade

    2015-03-01

    Full Text Available Introduction. A safe and effective transition from hospital to post-acute care is a complex and important physician competency. Milestones and Entrustable Professional Activities (EPA form the new educational rubric in Graduate Medical Education Training. “A safe and effective discharge from the hospital” is an EPA ripe for educational innovation.Methods. The authors collaborated in a qualitative process called mapping to define 22 of 142 Internal Medicine (IM curricular milestones related to the transition of care. Fifty-five participant units at an Association for Program Directors in Internal Medicine (APDIM workshop prioritized the milestones, using a validated ranking process called Q-sort. We analyzed the Q-sort results, which rank the milestones in order of priority. We then applied this ranking to three innovative models of training IM residents in the transitions of care: Simulation (S, Discharge Clinic Feedback (DCF and TRACER (T.Results. We collected 55 Q-sort rankings from particpants at the APDIM workshop. We then identified which milestones are a focus of the three innovative models of training in the transition of care: Simulation = 5 of 22 milestones, Discharge Clinic Feedback = 9 of 22 milestones, and TRACER = 7 of 22 milestones. Milestones identified in each innovation related to one of the top 8 prioritized milestones 75% of the time; thus, more frequently than the milestones with lower priority. Two milestones are shared by all three curricula: Utilize patient-centered education and Ensure succinct written communication. Two other milestones are shared by two curricula: Manage and coordinate care transitions across multiple delivery systems and Customize care in the context of the patient’s preferences. If you combine the three innovations, all of the top 8 milestones are included.Discussion. The milestones give us a context to share individual innovations and to compare and contrast using a standardized frame. We

  18. Milestones in the history of personality disorders.

    Science.gov (United States)

    Crocq, Marc-Antoine

    2013-06-01

    This paper analyzes the major historical milestones in the study of normal and abnormal personality, from antiquity up until the 20th century. Special attention is paid to the interaction between dimensional and typological approaches, which was a major issue during the preparation of DSM-5. Theories of personality started with the humoral theory of Greek medicine. Pinel, and later Esquirol and Prichard, are credited with the first descriptions of abnormal personalities in textbooks of psychiatry. Between the late 19th and early 20th centuries, elaborate systems of normal and abnormal personality, associating to some degree types and dimensions, were devised by a succession of European psychologists, such as Ribot, Heymans, and Lazursky. Emil Kraepelin and Kurt Schneider proposed classifications of abnormal personality types. In parallel, psychoanalysts stressed the role of early life experiences. Towards the mid-20th century, statistical methods were applied to the scientific validation of personality dimensions with pioneers such as Cattell, anticipating the five-factor model.

  19. The Pension Fund passes important milestones

    CERN Multimedia

    2012-01-01

    In this column, the Chairman of the Pension Fund Governing Board (PFGB) presents the Board's latest main decisions, initiatives and accomplishments to the Fund's members and beneficiaries.   Since my last report in October, the PFGB has passed several milestones in actuarial, technical and investment matters. The PFGB has completed an analysis of a request by the European Organisation for Astronomical Research in the Southern Hemisphere (ESO) to reduce the increased cost of pension insurance for new ESO recruits that has been caused by the increased CHF/€ exchange ratio. Currently the staff of ESO are admitted to the CERN Pension Fund, pursuant to a co-operation agreement between CERN and ESO dating back to 1968. This analysis assessed the actuarial, financial, administrative and legal implications, and is scheduled to be presented to the CERN Council and the Finance Committee in December. After an open tendering process the PFGB has selected Buck Consultants Limited...

  20. CMS Forward-Backward MSGC milestone

    CERN Document Server

    Bouhali, O; Barthe, S; Beaumont, W; Beckers, T; Beissel, F; Benhammou, Ya; Bergdolt, A M; Bernier, K; Boulogne, I; Bozzo, M; Brom, J M; Camps, C; Chorowicz, V; Coffin, J; Commichau, V; Contardo, D; Croix, J; De Troy, J G; Drouhin, F; Eberle, H; Flügge, G; Fontaine, J C; Geist, Walter M; Goerlach, U; Gundlfinger, K; Hangarter, K; Haroutunian, R; Helleboid, J M; Hoffer, M; Hoffmann, C; Huss, D; Ischebeck, R; Jeanneau, F; Juillot, P; Kapp, M R; Krauth, M; Kremp, J; Lounis, A; Lübelsmeyer, K; Maazouzi, C; Macke, D; Mirabito, L; Nowack, A; Pandoulas, D; Petertill, M; Pooth, O; Racca, C; Ripp, I; Schmitz, P; Schulte, R; Schultz von Dratzig, A; Schunck, J P; Schuster, G; Schwaller, B; Sigward, M H; Smadja, G; Stefanescu, J; Tissot, S; Todorov, T; Udo, Fred; Van Doninck, W K; Van Dyck, C; Van Lancker, L; Van der Velde, C; Vanlaer, P; Verdini, P G; Wortmann, R; Zghiche, A; Zhukov, V

    1998-01-01

    The CMS MF1 milestone was set in order to evaluate system aspects of the CMS forward-backward MSGC tracker, to check the design and feasibility of mass production and to set up assembly and test procedures. We describe the construction and the experience gained with the operation of a system of 38 MSGC detectors assembled in six multi-substrate detector modules corresponding to the geometry of the forward-backward MSGC tracker in CMS. These modules were equipped with MSGCs mounted side by side, forming a continuous detector surface of about 0.2 m2. Different designs were tried for these modules. The problems encountered are presented with the proposed solutions. Operation conditions for the 38 MSGCs are reported from an exposure to a muon beam at the CERN SPS. Gain uniformity along the wedge-shaped strip pattern and across the detector modules are shown together with the detection efficiency, the spatial resolution, alignment and edge studies.

  1. CMS Forward-Backward MSGC milestone

    CERN Document Server

    Bouhali, O; Barthe, S; Beaumont, W; Beckers, T; Beissel, F; Benhammou, Ya; Bergdolt, A M; Bernier, K; Boulogne, I; Bozzo, M; Brom, J M; Camps, C; Chorowicz, V; Coffin, J; Commichau, V; Contardo, D; Croix, J; De Troy, J G; Drouhin, F; Eberle, H; Flügge, G; Fontaine, J C; Geist, Walter M; Goerlach, U; Gundlfinger, K; Hangarter, K; Haroutunian, R; Helleboid, J M; Hoffer, M; Hoffmann, C; Huss, D; Ischebeck, R; Jeanneau, F; Juillot, P; Kapp, M R; Krauth, M; Kremp, J; Lounis, A; Lübelsmeyer, K; Maazouzi, C; Macke, D; Mirabito, L; Nowack, A; Pandoulas, D; Petertill, M; Pooth, O; Racca, C; Ripp, I; Schmitz, P; Schulte, R; Schultz von Dratzig, A; Schunck, J P; Schuster, G; Schwaller, B; Sigward, M H; Smadja, G; Stefanescu, J; Tissot, S; Todorov, T; Udo, Fred; Van Doninck, W K; Van Dyck, C; Van Lancker, L; Van der Velde, C; Vanlaer, P; Verdini, P G; Wortmann, R; Zghiche, A; Zhukov, V

    1998-01-01

    The CMS MF1 milestone was set in order to evaluate system aspects of the CMS forward-backward MSGC tracker, to check the design and feasibility of mass production and to set up assembly and test procedures. We describe the construction and the experience gained with the operation of a system of 38 MSGC detectors assembled in six multi-substrate detector modules corresponding to the geometry of the forward-backward MSGC tracker in CMS. These modules were equipped with MSGCs mounted side by side, forming a continuous detector surface of about 0.2 m2. Different designs were tried for these modules. The problems encountered are presented with the proposed solutions. Operation conditions for the 38 MSGCs are reported from an exposure to a muon beam at the CERN SPS. Gain uniformity along the wedge-shaped strip pattern and across the detector modules are shown together with the detection efficiency, the spatial resolution, alignment and edge studies.

  2. Artificial insemination history: hurdles and milestones.

    Science.gov (United States)

    Ombelet, W; Van Robays, J

    2015-01-01

    Artificial insemination with homologous (AIH) or donor semen (AID) is nowadays a very popular treatment procedure used for many subfertile women worldwide. The rationale behind artificial insemination is to increase gamete density at the site of fertilisation. The sequence of events leading to today's common use of artificial insemination traces back to scientific studies and experimentation many centuries ago. Modern techniques used in human artificial insemination programmes are mostly adapted from the work on cattle by dairy farmers wishing to improve milk production by using artificial insemination with sperm of selected bulls with well chosen genetic traits. The main reason for the renewed interest in artificial insemination in human was associated with the refinement of techniques for the preparation of washed motile spermatozoa in the early years of IVF. The history of artificial insemination is reviewed with particular interest to the most important hurdles and milestones.

  3. Noise-induced hearing loss milestones: Past and future

    CSIR Research Space (South Africa)

    Edwards, A

    2011-01-01

    Full Text Available At the 2003 Mine Health and Safety Summit, the milestones for elimination of Noise-induced Hearing Loss (NIHL) in the mining industry were agreed on. The first milestone, December 2008, has passed and the next one in 2013 is looming. The study...

  4. Developmental milestones in post-term born children

    DEFF Research Database (Denmark)

    Olesen, Annette Wind; Olsen, Jørn; Zhu, Jinliang

    at achieving developmental milestones with gestational age at birth in 9 out of 14 milestone items. Conclusion: Post-term born children appear to reach the main developmental milestones at an earlier age since birth than term born children. The association could also be due to bias related to a longer time......DEVELOPMENTAL MILESTONES IN POST-TERM BORN CHILDREN Annette Wind Olesen (1), Jorn Olsen (2), Jinliang Zhu (2) (1)Institute of Regional Health Research, University of Southern Denmark, (2)The Danish Epidemiology Science Centre, Aarhus University Objective: To examine the timing of reaching...... developmental milestones in children born post-term. Design: Cohort study. Material: The Danish National Birth Cohort; children born between 1997 and 2003. Data was obtained from a cohort of 92,892 pregnancies participating in the first pregnancy interview. All singletons born in gestational week 39-45 were...

  5. RELAP-7 Level 2 Milestone Report: Demonstration of a Steady State Single Phase PWR Simulation with RELAP-7

    Energy Technology Data Exchange (ETDEWEB)

    David Andrs; Ray Berry; Derek Gaston; Richard Martineau; John Peterson; Hongbin Zhang; Haihua Zhao; Ling Zou

    2012-05-01

    The document contains the simulation results of a steady state model PWR problem with the RELAP-7 code. The RELAP-7 code is the next generation nuclear reactor system safety analysis code being developed at Idaho National Laboratory (INL). The code is based on INL's modern scientific software development framework - MOOSE (Multi-Physics Object-Oriented Simulation Environment). This report summarizes the initial results of simulating a model steady-state single phase PWR problem using the current version of the RELAP-7 code. The major purpose of this demonstration simulation is to show that RELAP-7 code can be rapidly developed to simulate single-phase reactor problems. RELAP-7 is a new project started on October 1st, 2011. It will become the main reactor systems simulation toolkit for RISMC (Risk Informed Safety Margin Characterization) and the next generation tool in the RELAP reactor safety/systems analysis application series (the replacement for RELAP5). The key to the success of RELAP-7 is the simultaneous advancement of physical models, numerical methods, and software design while maintaining a solid user perspective. Physical models include both PDEs (Partial Differential Equations) and ODEs (Ordinary Differential Equations) and experimental based closure models. RELAP-7 will eventually utilize well posed governing equations for multiphase flow, which can be strictly verified. Closure models used in RELAP5 and newly developed models will be reviewed and selected to reflect the progress made during the past three decades. RELAP-7 uses modern numerical methods, which allow implicit time integration, higher order schemes in both time and space, and strongly coupled multi-physics simulations. RELAP-7 is written with object oriented programming language C++. Its development follows modern software design paradigms. The code is easy to read, develop, maintain, and couple with other codes. Most importantly, the modern software design allows the RELAP-7 code to evolve with time. RELAP-7 is a MOOSE-based application. MOOSE (Multiphysics Object-Oriented Simulation Environment) is a framework for solving computational engineering problems in a well-planned, managed, and coordinated way. By leveraging millions of lines of open source software packages, such as PETSC (a nonlinear solver developed at Argonne National Laboratory) and LibMesh (a Finite Element Analysis package developed at University of Texas), MOOSE significantly reduces the expense and time required to develop new applications. Numerical integration methods and mesh management for parallel computation are provided by MOOSE. Therefore RELAP-7 code developers only need to focus on physics and user experiences. By using the MOOSE development environment, RELAP-7 code is developed by following the same modern software design paradigms used for other MOOSE development efforts. There are currently over 20 different MOOSE based applications ranging from 3-D transient neutron transport, detailed 3-D transient fuel performance analysis, to long-term material aging. Multi-physics and multiple dimensional analyses capabilities can be obtained by coupling RELAP-7 and other MOOSE based applications and by leveraging with capabilities developed by other DOE programs. This allows restricting the focus of RELAP-7 to systems analysis-type simulations and gives priority to retain and significantly extend RELAP5's capabilities.

  6. Important ATLAS Forward Calorimeter Milestone Reached

    CERN Multimedia

    Loch, P.

    The ATLAS Forward Calorimeter working group has reached an important milestone in the production of their detectors. The mechanical assembly of the first electromagnetic module (FCal1C) has been completed at the University of Arizona on February 25, 2002, only ten days after the originally scheduled date. The photo shows the University of Arizona FCal group in the clean room, together with the assembled FCal1C module. The module consists of a stack of 18 round copper plates, each about one inch thick. Each plate is about 90 cm in diameter, and has 12260 precision-drilled holes in it, to accommodate the tube/rod electrode assembly. The machining of the plates, which was done at the Science Technology Center (STC) at Carleton University, Ottawa, Canada, required high precision to allow for easy insertion of the electrode copper tube. The plates have been carefully cleaned at the University of Arizona, to remove any machining residue and metal flakes. This process alone took about eleven weeks. Exactly 122...

  7. Important Milestone for REX-ISOLDE

    CERN Multimedia

    2001-01-01

    CERN's new nuclear physics facility, REX-ISOLDE, reached an important milestone on Thursday 23 August. Scheduled for full commissioning later this year, REX-ISOLDE will take beams of unstable ions from the ISOLDE facility and accelerate them, opening up a wide range of new research avenues. Members of the REX-ISOLDE team with REXEBIS - successfully tested last week. The key to REX-ISOLDE is the process of accumulating and cooling unstable ions in a trap and then stripping them of electrons in a so-called charge breeder before accelerating them in a linear accelerator. The first part of this process is the job of REXTRAP, the largest particle trap of its kind, which was successfully tested in 1999 (Bulletin 49/99). Last week it was the turn of REXEBIS (Electron Beam Ion Source), which strips the ions of electrons, to be put through its paces. By increasing the charge of the ions by removing electrons, the length of the linear accelerator needed to accelerate the ions can be reduced, since higher charge mean...

  8. Milestones in avian coccidiosis research: a review.

    Science.gov (United States)

    Chapman, H D

    2014-03-01

    This article describes some of the milestones in research concerned with protozoan parasites of the genus Eimeria that infect birds and cause the disease coccidiosis. The time period covered is from 1891, when oocysts were first found in the ceca of diseased chickens, to the present. Progress in our understanding has lagged behind that of other protozoan parasites such as Toxoplasma and Plasmodium despite the enormous importance of Eimeria to animal livestock production. Nevertheless, applied research by universities, government agencies, and private industry has resulted in the successful development of methods of control, research that continues today. The topics covered and the references provided are selective and include life cycles and biology, pathology, ultrastructure, biochemistry, immunity, genetics, host cell invasion, species identification, taxonomy, chemotherapy, vaccination, and literature concerned with avian coccidiosis. This review is primarily concerned with the avian species of Eimeria that infect poultry, but some important advances, principally in immunology, have been made using species that infect rodents and rabbits. These are included where appropriate.

  9. ASC Trilab L2 Codesign Milestone 2015

    Energy Technology Data Exchange (ETDEWEB)

    Trott, Christian Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hammond, Simon David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dinge, Dennis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Paul T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vaughan, Courtenay T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Jeanine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Edwards, Harold C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rajan, Mahesh [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoekstra, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    For the FY15 ASC L2 Trilab Codesign milestone Sandia National Laboratories performed two main studies. The first study investigated three topics (performance, cross-platform portability and programmer productivity) when using OpenMP directives and the RAJA and Kokkos programming models available from LLNL and SNL respectively. The focus of this first study was the LULESH mini-application developed and maintained by LLNL. In the coming sections of the report the reader will find performance comparisons (and a demonstration of portability) for a variety of mini-application implementations produced during this study with varying levels of optimization. Of note is that the implementations utilized including optimizations across a number of programming models to help ensure claims that Kokkos can provide native-class application performance are valid. The second study performed during FY15 is a performance assessment of the MiniAero mini-application developed by Sandia. This mini-application was developed by the SIERRA Thermal-Fluid team at Sandia for the purposes of learning the Kokkos programming model and so is available in only a single implementation. For this report we studied its performance and scaling on a number of machines with the intent of providing insight into potential performance issues that may be experienced when similar algorithms are deployed on the forthcoming Trinity ASC ATS platform.

  10. Level-1 Milestone 350 Definitions v1

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, T

    2006-11-17

    This milestone is the direct result of work that started seven years ago with the planning for a 100-teraFLOP platform and will be satisfied when 100 teraFLOPS is placed in operation and readied for Stockpile Stewardship Program simulations. The end product of this milestone will be a production-level, high-performance computing system, code named Purple, designed to be used to solve the most demanding stockpile stewardship problems, that is, the large-scale application problems at the edge of our understanding of weapon physics. This fully functional 100 teraFLOPS system must be able to serve a diverse scientific and engineering workload. It must also have a robust code development and production environment, both of which facilitate the workload requirements. This multi-year effort includes major activities in contract management, facilities, infrastructure, system software, and user environment and support. Led by LLNL, the trilabs defined the statement of work for a 100-teraFLOP system that resulted in a contract with IBM known as the Purple contract. LLNL worked with IBM throughout the contract period to resolve issues and collaborated with the Program to resolve contractual issues to ensure delivery of a platform that best serves the Program for a reasonable cost. The Purple system represents a substantial increase in the classified compute resources at LLNL for NNSA. The center computer environment must be designed to accept the Purple system and to scale with the increase of compute resources to achieve required end-to-end services. Networking, archival storage, visualization servers, global file systems, and system software will all be enhanced to support Purple's size and architecture. IBM and LLNL are sharing responsibility for Purple's system software. LLNL is responsible for the scheduler, resource manager, and some code development tools. Through the Purple contract, IBM is responsible for the remainder of the system software including the

  11. QUALITY MILESTONES OF THE SUSTAINABLE TOURISM

    Directory of Open Access Journals (Sweden)

    Tomescu Ada Mirela

    2014-12-01

    "! As a final remark, we mention as milestone of ecological behaviour (green connected to sustainable development are certification to ISO 14001 and eco-labelling of accommodation.

  12. One ID Card for the Entire Campus.

    Science.gov (United States)

    Ridenour, David P.; Ferguson, Linda M.

    1986-01-01

    The implementation by Indiana State University of a machine-readable photo ID system for their food services prompted an investigation into the available alternatives and requirements for a more efficient all-University ID card system. The new ID system is described. (AUTHOR/MLW)

  13. Guide to DCP Study Close-Out: Milestones and Tasks | Division of Cancer Prevention

    Science.gov (United States)

    This guide assists Consortium Lead Organization (CLO) planning for DCP study close-out. Study close-out tasks are organized under milestones, which help mark progress toward completion of the close-out process. Once tasks associated with a milestone are underway, planning for the next milestone may begin. Click on a milestone to view the associated close-out tasks. |

  14. VLM Tool for IDS Integration

    Directory of Open Access Journals (Sweden)

    Cǎtǎlin NAE

    2010-03-01

    Full Text Available This paper is dedicated to a very specific type of analysis tool (VLM - Vortex Lattice Method to be integrated in a IDS - Integrated Design System, tailored for the usage of small aircraft industry. The major interest is to have the possibility to simulate at very low computational costs a preliminary set of aerodynamic characteristics for basic aerodynamic global characteristics (Lift, Drag, Pitching Moment and aerodynamic derivatives for longitudinal and lateral-directional stability analysis. This work enables fast investigations of the influence of configuration changes in a very efficient computational environment. Using experimental data and/or CFD information for a specific calibration of VLM method, reliability of the analysis may me increased so that a first type (iteration zero aerodynamic evaluation of the preliminary 3D configuration is possible. The output of this tool is basic state aerodynamic and associated stability and control derivatives, as well as a complete set of information on specific loads on major airframe components.The major interest in using and validating this type of methods is coming from the possibility to integrate it as a tool in an IDS system for conceptual design phase, as considered for development for CESAR project (IP, UE FP6.

  15. ID Barrel installed in cryostat

    CERN Multimedia

    Apsimon, R.; Romaniouk, A.

    Wednesday 23rd August was a memorable day for the Inner Detector community as they witnessed the transport and installation of the central part of the inner detector (ID-barrel) into the ATLAS detector. Many members of the collaboration gathered to witness this moment at Point 1. After years of design, construction and commissioning, the outer two detectors (TRT and SCT) of the ID barrel were moved from the SR1 cleanroom to the ATLAS cavern. The barrel was moved across the car park from building 2175 to SX1. Although only a journey of about 100 metres, this required weeks of planning and some degree of luck as far as the weather was concerned. Accelerometers were fitted to the barrel to provide real-time monitoring and no values greater than 0.1 g were recorded, fully satisfying the transport specification for this extremely precise and fragile detector. Muriel, despite her fear of heights, bravely volunteered to keep a close eye on the detector. Swapping cranes to cross the entire parking lot, while Mur...

  16. L’idéologie

    Directory of Open Access Journals (Sweden)

    Paul Aron

    2007-02-01

    Full Text Available De Marx à BourdieuJugée essentielle dans les années septante, déclinée en colloques, ouvrages polémiques ou encyclopédiques divers, rythmée par les interventions théoriques de penseurs comme Antonio Gramsci, que l’on commençait à traduire en français, Louis Althusser, Lucien Sève ou Robert Fossaert, la problématique de l’idéologie a mobilisé les esprits à un point tel que le silence qui l’entoure aujourd’hui peut légitimement surprendre.Je commencerai par situer cette notion dans son cadre hi...

  17. Construction Milestone Announced on Green Bank Telescope

    Science.gov (United States)

    2000-04-01

    The National Radio Astronomy Observatory announces completion of a major construction milestone on the world's largest fully steerable radio telescope - the National Science Foundation's Green Bank Telescope (GBT). The last of 2,004 aluminum surface panels was recently installed on the GBT's two-acre (100 m x 110 m) collecting dish. The telescope is located at NRAO's Green Bank site, in rural Pocahontas County, West Virginia. The GBT will be used to study everything from the formation of galaxies in the early universe, to the chemical make-up of the dust and gas inside galaxies and in the voids that separate them, to the birth processes of stars. In conjunction with other instruments, it will help make highly accurate radar maps of some familiar objects in our own solar system. The GBT is an engineering marvel. At 485 feet tall, it is comparable in height to the Washington Monument. It weighs 16 million pounds, yet by swiveling the dish in both azimuth and elevation, it can be pointed to any point in the sky with exquisite accuracy. Additionally, the telescope's two-acre collecting dish has many novel features. Most radio telescopes in use today use receivers suspended above the dish by four struts. These struts block some of the surface of the dish, scattering some of the incoming radio waves from celestial objects under study. The GBT's offset feedarm has no struts to block incoming radio waves. The GBT also boasts an active surface. The surface of the dish is composed of 2,004 panels. On the underside of the dish, actuators are located at each corner (i.e., intersection of four panels). These actuators are motors that move the surface panels up and down, keeping the (paraboloid) shape of the dish precisely adjusted, no matter what the tilt of the telescope. The combination of its unblocked aperture and active surface promise that the GBT will display extremely high sensitivity to faint radio signals. The GBT itself is not the only precious national resource in

  18. MISR Level 2 Surface parameters V002

    Data.gov (United States)

    National Aeronautics and Space Administration — This Level 2 Land Surface product contains information on land directional reflectance properties,albedos(spectral & PAR integrated),FPAR,asssociated radiation...

  19. Tinjauan Desain Website kemlu.go.id

    Directory of Open Access Journals (Sweden)

    Danu Widhyatmoko

    2013-03-01

    Full Text Available Review of kemlu.go.id website design is a research report on Kemlu.go.id website design. Kemlu.go.id website aims to be the information gateway of Ministry of Foreign Affairs, and also as guidelines of foreign politic policies of Republic of Indonesia. The review had been accomplished by using analytical method based on the "Nine Essential Principles for Good Web Design" developed by Collis Ta'eed (2007. At the end of the article, several recommendations in developing kemlu.go.id website are presented to create better appearance.

  20. Swarm Level 2 Comprehensive Inversion, 2016 Production

    DEFF Research Database (Denmark)

    Tøffner-Clausen, Lars; Sabaka, Terence; Olsen, Nils;

    In the framework of the ESA Earth Observation Magnetic Mapping Mission Swarm, the Expert Support Laboratories (ESL) provides high quality Level 2 Products describing a.o. the magnetic fields of the Earth. This poster provides details of the Level 2 Products from the Comprehensive Inversion chain ...

  1. Apparatus as Milestones in the History of Comparative Psychology

    Science.gov (United States)

    Washburn, David A.; Rumbaugh, Duane M.; Putney, R. Thompson

    1994-01-01

    Significant apparatus developments from the history of comparative psychology are reviewed, including the contemporary trend toward computer use in research with nonhuman animals. It is argued that milestone apparatus served not only to open new lines of inquiry but also to shape or delimit the nature of the answers that were obtained.

  2. A Year of Milestones in Saudi Aramco's Relations with China

    Institute of Scientific and Technical Information of China (English)

    Liu Geng

    2010-01-01

    @@ 2010 has been a year of outstanding milestones in the bilateral relationship between China and the Kingdom of Saudi Arabia.China and Saudi Arabia conducted the fourth meeting of the Joint Committee on Economy and Trade this year,agreeing that bilateral trade will surpass US$60 billion annually by 2015.

  3. Milestones in history of adult vaccination in Korea

    OpenAIRE

    Oh, Myoung-don; Lee, Jong-koo

    2012-01-01

    Vaccination is one of the most effective and cost-benefit interventions that reduced the mortality. Major vaccine preventable diseases have decreased dramatically after the introduction of immunization program in Korea. In this article, we review milestones in history of immunization program, especially in adult vaccination.

  4. 10 CFR 603.570 - Determining milestone payment amounts.

    Science.gov (United States)

    2010-01-01

    ....570 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS... milestone payments should be associated with the well-defined, observable, and verifiable technical outcomes (e.g., demonstrations, tests, or data analysis) that are established for the project in accordance...

  5. UI researchers celebrate latest milestone in construction of atom smasher

    CERN Multimedia

    2007-01-01

    University of Iowa researchers joined their U.S. and international colleagues Dec. 19 in celebrating a major construction mile-stone that brings them one step closer to the completion of the most powerful device ever designed to search for the basic build-ing blocks of matter.

  6. UI researchers celebrate latest milestone in construction of atom smasher

    CERN Multimedia

    2007-01-01

    "University of Iowa researchers joined their U.S. and international colleagues De. 19 in celebrating a major construction mile-stone that brings them one step closer to the completion of the most powerful device ever designed to search for the basic build-ing blocks of matter." (1/2 page)

  7. DNS ID Covert Channel based on Lower Bound Steganography for Normal DNS ID Distribution

    Directory of Open Access Journals (Sweden)

    Abdulrahman H. Altalhi

    2011-11-01

    Full Text Available The covert channel is a method used to send secret data within a communication channel in unauthorized ways. This is performed by exploiting the weaknesses in packet or network communications with the intention to hide the existence of a covert communication. The DNS identification (DNS ID method has been exploited by Thyer. However, the major problem in Thyers implementation is that the encrypted cipher was directly inserted as a DNS ID value, which is abnormal, compared to the normal DNS ID distribution. We have overcome this problem through the application of Steganography to insert the cipher value into the DNS ID. The data set test for normal DNS ID is taken from MAWI. We tested four different message lengths and plotted the distribution graph. We found that the proposed result is normal compared to normal distribution of the DNS ID. Therefore, this method produces a normal distribution for DNS ID covert channel.

  8. Milestones toward Majorana-based quantum computing (Conference Presentation)

    Science.gov (United States)

    Mishmash, Ryan V.; Aasen, David; Hell, Michael; Higginbotham, Andrew; Danon, Jeroen; Leijnse, Martin; Jespersen, Thomas S.; Folk, Joshua A.; Marcus, Charles M.; Flensberg, Karsten; Alicea, Jason

    2016-10-01

    We introduce a scheme for preparation, manipulation, and readout of Majorana zero modes in semiconducting wires with mesoscopic superconducting islands. Our approach synthesizes recent advances in materials growth with tools commonly used in quantum-dot experiments, including gate-control of tunnel barriers and Coulomb effects, charge sensing, and charge pumping. We outline a sequence of milestones interpolating between zero-mode detection and quantum computing that includes (1) detection of fusion rules for non-Abelian anyons using either proximal charge sensors or pumped current; (2) validation of a prototype topological qubit; and (3) demonstration of non-Abelian statistics by braiding in a branched geometry. The first two milestones require only a single wire with two islands, and additionally enable sensitive measurements of the system's excitation gap, quasiparticle poisoning rates, residual Majorana zero-mode splittings, and topological-qubit coherence times. These pre-braiding experiments can be adapted to other manipulation and readout schemes as well.

  9. Historical milestones and discoveries that shaped the toxicology sciences.

    Science.gov (United States)

    Hayes, Antoinette N; Gilbert, Steven G

    2009-01-01

    Knowledge of the toxic and healing properties of plants, animals, and minerals has shaped civilization for millennia. The foundations of modern toxicology are built upon the significant milestones and discoveries of serendipity and crude experimentation. Throughout the ages, toxicological science has provided information that has shaped and guided society. This chapter examines the development of the discipline of toxicology and its influence on civilization by highlighting significant milestones and discoveries related to toxicology. The examples shed light on the beginnings of toxicology, as well as examine lessons learned and re-learned. This chapter also examines how toxicology and the toxicologist have interacted with other scientific and cultural disciplines, including religion, politics, and the government. Toxicology has evolved to a true scientific discipline with its own dedicated scientists, educational institutes, sub-disciplines, professional societies, and journals. It now stands as its own entity while traversing such fields as chemistry, physiology, pharmacology, and molecular biology. We invite you to join us on a path of discovery and to offer our suggestions as to what are the most significant milestones and discoveries in toxicology. Additional information is available on the history section of Toxipedia (www.toxipedia.org).

  10. The ATLAS Level-2 Trigger Pilot Project

    CERN Document Server

    Wickens, F J

    2000-01-01

    The Level-2 Trigger Pilot Project of ATLAS, one of the two general purpose LHC experiments, is part of the on-going programme to develop the ATLAS High Level Triggers (HLT). The Level-2 Trigger will receive events at up to 100 kHz, which has to be reduced to a rate suitable for full event-building of the order of 1 kHz. To reduce the data collection bandwidth and processing power required for the challenging Level-2 task it is planned to use Region of Interest guidance (from Level-1) and sequential processing. The Pilot Project included the construction and use of testbeds of up to 48 processing nodes, development of optimised components and computer simulations of a full system. It has shown how the required performance can be achieved, using largely commodity components and operating systems, and validated an architecture for the Level-2 system. This paper describes the principal achievements and conclusions of this project. (28 refs).

  11. Inhibitor of differentiation 4 (ID4): From development to cancer.

    Science.gov (United States)

    Patel, Divya; Morton, Derrick J; Carey, Jason; Havrda, Mathew C; Chaudhary, Jaideep

    2015-01-01

    Highly conserved Inhibitors of DNA-Binding (ID1-ID4) genes encode multi-functional proteins whose transcriptional activity is based on dominant negative inhibition of basic helix-loop-helix (bHLH) transcription factors. Initial animal models indicated a degree of compensatory overlap between ID genes such that deletion of multiple ID genes was required to generate easily recognizable phenotypes. More recently, new model systems have revealed alterations in mice harboring deletions in single ID genes suggesting complex gene and tissue specific functions for members of the ID gene family. Because ID genes are highly expressed during development and their function is associated with a primitive, proliferative cellular phenotype there has been significant interest in understanding their potential roles in neoplasia. Indeed, numerous studies indicate an oncogenic function for ID1, ID2 and ID3. In contrast, the inhibitor of differentiation 4 (ID4) presents a paradigm shift in context of well-established role of ID1, ID2 and ID3 in development and cancer. Apart from some degree of functional redundancy such as HLH dependent interactions with bHLH protein E2A, many of the functions of ID4 are distinct from ID1, ID2 and ID3: ID4 proteins a) regulate distinct developmental processes and tissue expression in the adult, b) promote stem cell survival, differentiation and/or timing of differentiation, c) epigenetic inactivation/loss of expression in several advanced stage cancers and d) increased expression in some cancers such as those arising in the breast and ovary. Thus, in spite of sharing the conserved HLH domain, ID4 defies the established model of ID protein function and expression. The underlying molecular mechanism responsible for the unique role of ID4 as compared to other ID proteins still remains largely un-explored. This review will focus on the current understanding of ID4 in context of development and cancer. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Id-1 and Id-2 genes and products as markers of epithelial cancer

    Energy Technology Data Exchange (ETDEWEB)

    Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

    2011-10-04

    A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

  13. Id-1 and Id-2 genes and products as markers of epithelial cancer

    Science.gov (United States)

    Desprez, Pierre-Yves [El Cerrito, CA; Campisi, Judith [Berkeley, CA

    2011-10-04

    A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

  14. Id-1 and Id-2 genes and products as markers of epithelial cancer

    Science.gov (United States)

    Desprez, Pierre-Yves; Campisi, Judith

    2008-09-30

    A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

  15. Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances.

    Directory of Open Access Journals (Sweden)

    Qingshi Zhao

    Full Text Available The Inhibitor of DNA Binding (Id proteins play a crucial role in regulating hematopoiesis and are known to interact with E proteins and the bHLH family of transcription factors. Current efforts seek to elucidate the individual roles of Id members in regulating hematopoietic development and specification. However, the nature of their functional redundancies remains elusive since ablation of multiple Id genes is embryonically lethal. We developed a model to test this compensation in the adult. We report that global Id3 ablation with Tie2Cre-mediated conditional ablation of Id1 in both hematopoietic and endothelial cells (Id cDKO extends viability to 1 year but leads to multi-lineage hematopoietic defects including the emergence of anemia associated with defective erythroid development, a novel phenotype unreported in prior single Id knockout studies. We observe decreased cell counts in the bone marrow and splenomegaly to dimensions beyond what is seen in single Id knockout models. Transcriptional dysregulation of hematopoietic regulators observed in bone marrow cells is also magnified in the spleen. E47 protein levels were elevated in Id cDKO bone marrow cell isolates, but decreased in the erythroid lineage. Chromatin immunoprecipitation (ChIP studies reveal increased occupancy of E47 and GATA1 at the promoter regions of β-globin and E2A. Bone marrow transplantation studies highlight the importance of intrinsic Id signals in maintaining hematopoietic homeostasis while revealing a strong extrinsic influence in the development of anemia. Together, these findings demonstrate that loss of Id compensation leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice.

  16. Analyzing milestoning networks for molecular kinetics: definitions, algorithms, and examples.

    Science.gov (United States)

    Viswanath, Shruthi; Kreuzer, Steven M; Cardenas, Alfredo E; Elber, Ron

    2013-11-07

    Network representations are becoming increasingly popular for analyzing kinetic data from techniques like Milestoning, Markov State Models, and Transition Path Theory. Mapping continuous phase space trajectories into a relatively small number of discrete states helps in visualization of the data and in dissecting complex dynamics to concrete mechanisms. However, not only are molecular networks derived from molecular dynamics simulations growing in number, they are also getting increasingly complex, owing partly to the growth in computer power that allows us to generate longer and better converged trajectories. The increased complexity of the networks makes simple interpretation and qualitative insight of the molecular systems more difficult to achieve. In this paper, we focus on various network representations of kinetic data and algorithms to identify important edges and pathways in these networks. The kinetic data can be local and partial (such as the value of rate coefficients between states) or an exact solution to kinetic equations for the entire system (such as the stationary flux between vertices). In particular, we focus on the Milestoning method that provides fluxes as the main output. We proposed Global Maximum Weight Pathways as a useful tool for analyzing molecular mechanism in Milestoning networks. A closely related definition was made in the context of Transition Path Theory. We consider three algorithms to find Global Maximum Weight Pathways: Recursive Dijkstra's, Edge-Elimination, and Edge-List Bisection. The asymptotic efficiency of the algorithms is analyzed and numerical tests on finite networks show that Edge-List Bisection and Recursive Dijkstra's algorithms are most efficient for sparse and dense networks, respectively. Pathways are illustrated for two examples: helix unfolding and membrane permeation. Finally, we illustrate that networks based on local kinetic information can lead to incorrect interpretation of molecular mechanisms.

  17. The Fifth Milestone in the Development of Chinese Language

    Directory of Open Access Journals (Sweden)

    Mateja PETROVČIČ

    2013-04-01

    Full Text Available Chinese language has changed drastically in the recent century. Papers on the language development mainly stress four big events in the Chinese history that imposed changes in language, i.e. The May Fourth Movement (1919, establishment of the People’s Republic of China (1949, Cultural Revolution (1966, and China’s reform and opening (1978. According to the features of recent neologisms, we suggest that the widening gap between rich and poor should be considered as the fifth milestone for changes in Chinese language.

  18. Studies with Muons in ATLAS: TileCal Level-2 Trigger and MSSM Higgs Discovery Reach

    CERN Document Server

    Ruiz Martínez, A; Valls Ferrer, J A

    2009-01-01

    This thesis was carried out in the years previous to the LHC start-up, i.e. during the ATLAS detector commissioning phase. It contains an introductory part about the detector and its expected physics performance and two main parts about the development of a Level-2 trigger for muons and a study of the MSSM Higgs discovery reach with simulated data, which are briefly described below. The first part of the thesis is devoted to TileMuId, the muon identication algorithm based on TileCal whose main goal is to be used as a Level-2 trigger of low-$p_{\\text{T}}$ muons. A second version of TileMuId (ROD-based) has been implemented to run in the TileCal ROD DSPs. This involved developments in the DSP firmware and in the Athena framework, described in the document. In addition, studies of the algorithm performance in terms of efficiency and fraction of fakes have been done. Developments and studies to match the TileCal muon candidates with the Inner Detector tracks (provided by ID reconstruction algorithms) have been pe...

  19. Timing of motor milestones achievement and development of overweight in childhood

    DEFF Research Database (Denmark)

    Morgen, Camilla Schmidt; Andersen, Anne-Marie Nybo; Due, P;

    2014-01-01

    on motor milestones and childhood overweight is limited and results are inconsistent. WHAT THIS STUDY ADDS: Weight status in early life and timing of achievement of gross motor milestones (the ability to sit and walk) are largely independent of each other. Timing of achievement of motor milestones in early...... life does not predict overweight or increased BMI later in childhood. BACKGROUND: Overweight may hinder achievement of gross motor milestones and delayed achievement of milestones may increase the risk of later overweight for reasons involving physical activity and the building of lean body mass....... OBJECTIVE: To investigate whether increased birth weight and body mass index (BMI) at 5 months is associated with the achievement of the ability to sit up and walk and whether delayed achievement of these milestones is associated with overweight at age 7 years. METHODS: We used data from the Danish National...

  20. Predicting real-world functional milestones in schizophrenia.

    Science.gov (United States)

    Olsson, Anna-Karin; Hjärthag, Fredrik; Helldin, Lars

    2016-08-30

    Schizophrenia is a severe disorder that often causes impairments in major areas of functioning, and most patients do not achieve expected real-world functional milestones. The aim of this study was to identify which variables of demography, illness activity, and functional capacity predict patients' ability to attain real-world functional milestones. Participants were 235 outpatients, 149 men and 86 women, diagnosed with schizophrenia spectrum disorder. Our results showed that younger patients managed to achieve a higher level of functioning in educational level, marital status, and social contacts. Patients' functional capacity was primarily associated with educational level and housing situation. We also found that women needed less support regarding housing and obtained a higher level of marital status as compared with men. Our findings demonstrate the importance of considering current symptoms, especially negative symptoms, and remission stability over time, together with age, duration of illness, gender, educational level, and current functional capacity, when predicting patients' future real-world functioning. We also conclude that there is an advantage in exploring symptoms divided into positive, negative, and general domains considering their probable impact on functional achievements.

  1. Noorteadlased kaitsesid doktoritöid

    Index Scriptorium Estoniae

    2002-01-01

    13. sept. 2002.a. kaitsesid TPÜ-s doktoritöid Mare Leino ("Sotsiaalsed probleemid koolis ja õpetaja toimetulek" ja Maaris Raudsepp ("Loodussäästlikkus kui regulatiivne idee: sotsiaal-psühholoogiline analüüs")

  2. Independence Day 2004 (ID04) / Raul Hindov

    Index Scriptorium Estoniae

    Hindov, Raul

    2004-01-01

    Ülevaade 20.-22. veebruarini 2004 toimunud kaugluurepatrullide rännaku ja sõdurioskuste kompleksõppusest ID04 (Independence Day 2004 - Iseseisvuspäev 2004), millel osales 25 patrullvõistlusteks valmistuvat meest ja naist

  3. Independence Day 2004 (ID04) / Raul Hindov

    Index Scriptorium Estoniae

    Hindov, Raul

    2004-01-01

    Ülevaade 20.-22. veebruarini 2004 toimunud kaugluurepatrullide rännaku ja sõdurioskuste kompleksõppusest ID04 (Independence Day 2004 - Iseseisvuspäev 2004), millel osales 25 patrullvõistlusteks valmistuvat meest ja naist

  4. Selection of starter cultures for idli batter fermentation and their effect on quality of idlis.

    Science.gov (United States)

    Sridevi, J; Halami, Prakash M; Vijayendra, S V N

    2010-10-01

    Idli batter samples were prepared using lactic starter cultures like Pediococcus pentosaceus (Pp), Enterococcus faecium MTCC 5153 (Ef), Ent. faecium (IB2 Ef-IB2), individually, along with the yeast culture, Candida versatilis (Cv). Idli batter prepared using Ef and Ef-IB2 cultures gave better results, when evaluated for the rise in batter volume (80 ml), level of CO2 production (23.8%), titratable acidity 2.4-3.5% (lactic acid) and pH 4.3-4.4. Storage stability of batter made with selected starter cultures was determined by analyzing the idlis prepared using the batter stored for 1 and 5 days for texture, nutrient composition and sensory quality. Slight variations in the results were seen among the idlis of different combination of cultures, whereas these results are better than that of the idlis made using naturally fermented idli batter. Sensory profile of idlis prepared using starter cultures had a higher score (3.9-4.4) compared to the control (3.6) for overall acceptability.

  5. Predictors of motor developmental milestones during the first year of life

    DEFF Research Database (Denmark)

    Flensborg-Madsen, Trine; Mortensen, Erik Lykke

    2017-01-01

    of a broad selection of possible predictors of age at milestone attainment and to identify factors that explain significant inter-individual variance. Mothers of 5765 children of the Copenhagen Perinatal Cohort (1959-61) recorded 12 developmental milestones prospectively during the child's first year of life...... in the first year, were significantly associated with milestone attainment in the first year of life. Variables within the domain of Pregnancy and delivery explained the largest proportion of variance in milestone attainment compared to the other domains. What is known: • Younger age at attainment of motor...

  6. CMMI Level 2 for Practitioners: A Focused Course for Your Level 2 Efforts

    Science.gov (United States)

    2016-06-13

    burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services ...CM) • Process and Product Quality Assurance (PPQA) • Measurement and Analysis (MA) 10 CMMI Level 2 for Practitioners Webinar Mary Beth Chrissis May...Maturity Level 2 Lunch Exercise 1 Module 3: Generic Goals and Practices Module4: Product Development I Day 2 Module 5: Managing the Project (PP

  7. IDS in Telecommunication Network using PCA

    Directory of Open Access Journals (Sweden)

    T. K. Abdelhamid

    2013-07-01

    Full Text Available Data Security has become a very serious part of any organizational information system.Internet threatshavebecome moreintelligentso itcan deceivethe basic security solutions such as firewalls and antivirusscanners.To enhance the overall security of the networkan additional security layer such asintrusiondetection system(IDShas to be added.The anomaly detection IDSisa typeof IDS thatcandifferentiatebetweennormal and abnormal in thedata monitored. This paper proposes two types of IDS, oneof themcanbeusedasa network intrusion detection system(NIDS with overallsuccess (0.9161 and highdetection rate (0.9288 andtheothertypecanalso beusedasa host intrusion detection system(HIDS withoverall success (0.8493 and very high detection rate (0.9628using NSL-KDD data set

  8. Haro sur l’idéologie

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Bertrand

    2007-02-01

    Full Text Available Consacrer une journée d’études à la question de l’idéologie dans les études littéraires, ce n’est pas réhabiliter une notion qui a porté toute la tradition sociocritique, de Lukàcs à Hamon, en passant par Barthes, Dubois, Duchet et tant d’autres, en référence à la célèbre définition qu’en avait donné Althusser dans Positions. Ce n’est pas non plus enterrer très idéologiquement une notion dont on découvrirait, en cette ère de postmodernité, l’incongruité opérationnelle. C’est pour le moins fai...

  9. Identification of milestone papers through time-balanced network centrality

    CERN Document Server

    Mariani, Manuel Sebastian; Zhang, Yi-Cheng

    2016-01-01

    Citations between scientific papers and related bibliometric indices, such as the $h$-index for authors and the impact factor for journals, are being increasingly used -- often in controversial ways -- as quantitative tools for research evaluation. Yet, a fundamental research question remains still open: to which extent do quantitative metrics capture the significance of scientific works? We analyze the network of citations among the $449,935$ papers published by the American Physical Society (APS) journals between $1893$ and $2009$, and focus on the comparison of metrics built on the citation count with network-based metrics. We contrast five article-level metrics with respect to the rankings that they assign to a set of fundamental papers, called Milestone Letters, carefully selected by the APS editors for "making long-lived contributions to physics, either by announcing significant discoveries, or by initiating new areas of research". A new metric, which combines PageRank centrality with the explicit requi...

  10. Psychosocial developmental milestones in men with classic galactosemia.

    Science.gov (United States)

    Gubbels, Cynthia Sophia; Maurice-Stam, Heleen; Berry, Gerard Thomas; Bosch, Annet Maria; Waisbren, Susan; Rubio-Gozalbo, Maria Estela; Grootenhuis, Martha Alexandra

    2011-04-01

    Patients with classic galactosemia suffer from several long term effects of their disease. Research in a group of mainly female patients has shown that these patients may also have a developmental delay with regard to their social aptitude. To study if male galactosemia patients achieve psychosocial developmental milestones more slowly than male peers from the general Dutch population, we assessed their development with the Course of Life Questionnaire (CoLQ). A total of 18 male galactosemia patients participated in this study (response rate 69%): 11 Dutch patients and seven American patients. We found severe delays in the social and psychosexual scales of this questionnaire, but not on the autonomy axis. These results are comparable to an earlier study with a limited number of male patients. The observed delays could be secondary to less developed social skills, cognitive dysfunction, or disrupted language development. We strongly recommend screening of galactosemia patients for developmental delays, to ensure early intervention through social skills training.

  11. Milestones in the discovery of antiviral agents: nucleosides and nucleotides

    Directory of Open Access Journals (Sweden)

    Erik de Clercq

    2012-12-01

    Full Text Available In this review article, a number of milestones in the antiviral research field on nucleosides and nucleotides are reviewed in which the author played a significant part, especially in the initial stages of their development. Highlighted are the amino acyl esters of acyclovir, particularly valacyclovir (VACV, brivudin (BVDU and the valine ester of Cf1743 (FV-100, the 2′,3′-dideoxynucleosides (nucleoside reverse transcriptase inhibitors, NRTIs, the acyclic nucleoside phosphonates (S-HPMPA, (S-HPMPC (cidofovir and alkoxyalkyl esters thereof (HDP-, ODE-CDV, adefovir and adefovir dipivoxil, tenofovir and tenofovir disoproxil fumarate (TDF, combinations containing TDF and emtricitabine, i.e., Truvada®, Atripla®, Complera®/Eviplera® and the Quad pill, and the phosphonoamidate derivatives GS-7340, GS-9131, GS-9191 and GS-9219.

  12. Collider baseline parameters: Milestone M1.5

    CERN Document Server

    Schulte, Daniel

    2016-01-01

    The deliverable D1.1 provided a preliminary specification of the layout and target operation parameters for the FCC-hh hadron collider concept. It serves as the basis for the studies in all work packages. Tis milestone summarises the outcome of the first studies of this design. The goal of the FCC hadron collider is to provide proton-proton collisions at a centre-of-mass energy of 100 TeV. The machine is compatible with ion beam operation. Assuming a nominal dipole field of 16 T, such a machine is based on a perimeter of 100 km. The machine is designed to accommodate two main proton experiments that are operated simultaneously. The machine delivers a peak luminosity of 5-30 x 1034 cm-2s-1. The layout allows for two additional special-purpose experiments.

  13. EPA Interim Evaluation of 2012-2013 Milestone Progress in the Chesapeake Bay Watershed

    Science.gov (United States)

    This page provides the EPA interim evaluations of the 2012-2013 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2012-2013 milestones, recognizing the achievements made in 2012.

  14. Milestone achievement in emerging adulthood in spina bifida: a longitudinal investigation of parental expectations.

    Science.gov (United States)

    Holbein, Christina E; Zebracki, Kathy; Bechtel, Colleen F; Lennon Papadakis, Jaclyn; Franks Bruno, Elizabeth; Holmbeck, Grayson N

    2017-03-01

    To assess changes over time in parents' expectations of adult milestone achievement (college attendance, full-time job attainment, independent living, marriage, parenthood) for young people with spina bifida, to examine how expectancies relate to actual milestone achievement, and to compare milestone achievement in emerging adults with spina bifida with that of peers with typical development. Sixty-eight families of children with spina bifida (mean age 8y 4mo, 37 males, 31 females) and 68 families of children with typical development (mean age 8y 6mo, 37 males, 31 females) participated at Time 1. At all subsequent timepoints, parents of young people with spina bifida were asked to rate their expectations of emerging adulthood milestone achievement. At Time 7, when participants were 22 to 23 years old, milestone achievement was assessed. Parents of young people with spina bifida lowered their expectations over time for most milestones; parents of children with higher cognitive ability reported decreases of lower magnitude. Parent expectancies were optimistic and unrelated to actual milestone achievement. Emerging adults with spina bifida were less likely than individuals with typical development to achieve all milestones. Optimistic parental expectations may be adaptive for children with spina bifida and their families, although it is important for families to set realistic goals. Healthcare providers serve a key role in helping families of young people with spina bifida prepare for emerging adulthood. © 2016 Mac Keith Press.

  15. P-23 Highlights 6/10/12: Cygnus Dual Beam Radiographic Facility Refurbishment completed at U1A tunnel in Nevada NNSS meeting Level 2 milestone

    Energy Technology Data Exchange (ETDEWEB)

    Deyoung, Anemarie [Los Alamos National Laboratory; Smith, John R. [Los Alamos National Laboratory

    2012-05-03

    A moratorium was placed on U.S. underground nuclear testing in 1992. In response, the Stockpile Stewardship Program was created to maintain readiness of the existing nuclear inventory through several efforts such as computer modeling, material analysis, and subcritical nuclear experiments (SCEs). As in the underground test era, the Nevada National Security Site (NNSS), formerly the Nevada Test Site, provides a safe and secure environment for SCEs by the nature of its isolated and secure facilities. A major tool for SCE diagnosis installed in the 05 drift laboratory is a high energy x-ray source used for time resolved imaging. This tool consists of two identical sources (Cygnus 1 and Cygnus 2) and is called the Cygnus Dual Beam Radiographic Facility (Figs. 2-6). Each Cygnus machine has 5 major elements: Marx Generator, Pulse Forming Line (PFL), Coaxial Transmission Line (CTL), 3-cell Inductive Voltage Adder (IVA), and Rod Pinch Diode. Each machine is independently triggered and may be fired in separate tests (staggered mode), or in a single test where there is submicrosecond separation between the pulses (dual mode). Cygnus must operate as a single shot machine since on each pulse the diode electrodes are destroyed. The diode is vented to atmosphere, cleaned, and new electrodes are inserted for each shot. There is normally two shots per day on each machine. Since its installation in 2003, Cygnus has participated in: 4 Subcritical Experiments (Armando, Bacchus, Barolo A, and Barolo B), a 12 shot plutonium physics series (Thermos), and 2 plutonium step wedge calibration series (2005, 2011), resulting in well over 1000 shots. Currently the Facility is in preparation for 2 SCEs scheduled for this calendar year - Castor and Pollux. Cygnus has performed well during 8 years of operations at NNSS. Many improvements in operations and performance have been implemented during this time. Throughout its service at U1a, major maintenance and replacement of many hardware items were delayed due to programmatic requirements. It is anticipated that Cygnus will be in service at U1a for another 5 years. With this assumption, it was realized that significant resources and effort should be allotted to bring the hardware back to its original condition, or even to improve elements when appropriate. The Cygnus Refurbishment and Enhancement Project started in April, 2011 with the intent to encompass a major overhaul of Cygnus.

  16. A Process for Curricular Improvement Based on Evaluation of Student Performance on Milestone Examinations

    Science.gov (United States)

    Hylton, Ann C.; Justice, Michael

    2016-01-01

    Objective. To identify and address areas for curricular improvement by evaluating student achievement of expected learning outcomes and competencies on annual milestone examinations. Design. Students were tested each professional year with a comprehensive milestone examination designed to evaluate student achievement of learning outcomes and professional competencies using a combination of multiple-choice questions, standardized patient assessments (SPAs), and objective structured clinical examination (OSCE) questions. Assessment. Based on student performance on milestone examinations, curricular changes were instituted, including an increased emphasis on graded comprehensive cases, OSCE skills days, and use of patient simulation in lecture and laboratory courses. After making these changes, significant improvements were observed in second and third-year pharmacy students’ grades for the therapeutic case and physician interaction/errors and omissions components of the milestone examinations. Conclusion. Results from milestone examinations can be used to identify specific areas in which curricular improvements are needed to foster student achievement of learning outcomes and professional competencies. PMID:28090108

  17. Development of level 2 PSA technology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dong Ha; Park, Soo Yong; Kim, See Darl; Song, Yong Mann; Ahn, Kwang Il; Park, Jae Wu; Jin, Young Ho

    1997-07-01

    The objective of this project is the development of the computer code system for level 2 probabilistic safety assessment (PSA) of nuclear power plants. The scope of the project can be divided into three areas. The first area is to develop the computer code (CONPAS) which can quantify the accident progression event trees. CONPAS beta version has been developed this year and it is comprised of four modules : (1) EDITOR for generating the event tree logic diagrams and (2) COMPUTER for event tree quantification and for additional use of the calculated results. (3) TEXT EDITOR and (4) CODE PLOTTER. Comparing with the existing computer code, the present code provides a flexible code reusability and user interface, convenient edition of logic diagram, data operation, and systematic quantification of the results. The methodology development of containment structural analysis is the second area. The specific tasks included the collection and analysis of the containment failure modes for the various containment types, and the methodology establishment for the containment structure analysis. Over twenty large dry PWR containments, the database for containment failure mode and pressure has been constructed and the simplified fragility model has been proposed to calculate the containment failure probability. They will be used as an important input not only in the containment analysis but also in the source term analysis. For the last, source term analyzing methodology and its applied computer code that is named as `KORSOR` are developed. KORSOR which used parametric model approach combined modules which consist of accident sequence input module via user`s logic rule, random sample generating module, parametric database module, and source term uncertainty quantification module. The characteristics of parametric data which use din the source term analyzing model is analyzed and the constructing idea and example for the parametric database is suggested. (author). 67 refs., 66 tabs

  18. Milestone-Based Assessments Are Superior to Likert-Type Assessments in Illustrating Trainee Progression.

    Science.gov (United States)

    Bartlett, Kathleen W; Whicker, Shari A; Bookman, Jack; Narayan, Aditee P; Staples, Betty B; Hering, Holly; McGann, Kathleen A

    2015-03-01

    The Pediatrics Milestone Project uses behavioral anchors, narrative descriptions of observable behaviors, to describe learner progression through the Accreditation Council for Graduate Medical Education competencies. Starting June 2014, pediatrics programs were required to submit milestone reports for their trainees semiannually. Likert-type scale assessment tools were not designed to inform milestone reporting, creating a challenge for Clinical Competency Committees. To determine if milestone-based assessments better stratify trainees by training level compared to Likert-type assessments. We compared assessment results for 3 subcompetencies after changing from a 5-point Likert scale to milestone-based behavioral anchors in July 2013. Program leadership evaluated the new system by (1) comparing PGY-1 mean scores on Likert-type versus milestone-based assessments; and (2) comparing mean scores on the Likert-type versus milestone-based assessments across PGY levels. Mean scores for PGY-1 residents were significantly higher on the prior year's Likert-type assessments than milestone-based assessments for all 3 subcompetencies (P Likert-type assessments (eg, interpersonal and communication skills 1 [ICS1] mean score for PGY-1, 3.99 versus PGY-3, 3.98; P  =  .98). In contrast, milestone-based assessments demonstrated stratification by PGY level (eg, the ICS1 mean score was 3.06 for PGY-1, 3.83 for PGY-2, and 3.99 for PGY-3; P Likert-type assessments. Average PGY-level scores from milestone-based assessments may ultimately provide guidance for determining whether trainees are progressing at the expected pace.

  19. Medical Student Core Clinical Ultrasound Milestones: A Consensus Among Directors in the United States.

    Science.gov (United States)

    Dinh, Vi Am; Lakoff, Daniel; Hess, Jamie; Bahner, David P; Hoppmann, Richard; Blaivas, Michael; Pellerito, John S; Abuhamad, Alfred; Khandelwal, Sorabh

    2016-02-01

    Many medical schools are implementing point-of-care ultrasound in their curricula to help augment teaching of the physical examination, anatomy, and ultimately clinical management. However, point-of-care ultrasound milestones for medical students remain unknown. The purpose of this study was to formulate a consensus on core medical student clinical point-of-care ultrasound milestones across allopathic and osteopathic medical schools in the United States. Directors who are leading the integration of ultrasound in medical education (USMED) at their respective institutions were surveyed. An initial list of 205 potential clinical ultrasound milestones was developed through a literature review. An expert panel consisting of 34 USMED directors across the United States was used to produce consensus on clinical ultrasound milestones through 2 rounds of a modified Delphi technique, an established anonymous process to obtain consensus through multiple rounds of quantitative questionnaires. There was a 100% response rate from the 34 USMED directors in both rounds 1 and 2 of the modified Delphi protocol. After the first round, 2 milestones were revised to improve clarity, and 9 were added on the basis of comments from the USMED directors, resulting in 214 milestones forwarded to round 2. After the second round, only 90 milestones were found to have a high level of agreement and were included in the final medical student core clinical ultrasound milestones. This study established 90 core clinical milestones that all graduating medical students should obtain before graduation, based on consensus from 34 USMED directors. These core milestones can serve as a guide for curriculum deans who are initiating ultrasound curricula at their institutions. The exact method of implementation and competency assessment needs further investigation. © 2016 by the American Institute of Ultrasound in Medicine.

  20. Tarbijakaitse ei sekku esialgu ID-pileti projekti / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2004-01-01

    Tallinna ID-pileti müügil teenustasu võtmist arvustanud riigi tarbijakaitse amet ei sekku esialgu käivituvasse projekti, sest linnavalitsus võimaldab osta kahest teeninduspunktist ID-piletit ka teenustasuta

  1. Remembering one's ID/E-ntity: E/ID protein regulation of T cell memory.

    Science.gov (United States)

    Omilusik, Kyla D; Shaw, Laura A; Goldrath, Ananda W

    2013-10-01

    Upon infection, CD8(+) T cells proliferate and differentiate into armed effector cells capable of eliminating the assaulting pathogen. Although the majority of the antigen-specific T cells will die as the immune response wanes, a few will survive indefinitely to establish the memory population and provide long-lived protection against reinfection. E protein transcription factors and their inhibitors, ID proteins, operate to balance expression of genes that control CD8(+) T cell differentiation through this process. Here, we discuss the role of ID2 and ID3 in promoting the generation and survival of effector and memory populations, particularly highlighting their reciprocal roles in shaping the CD8(+) T cell response unique to the inflammatory milieu. We further examine this coordinated control of gene expression in the context of additional transcription factors within the transcriptional network that programs CD8(+) effector and memory T cell differentiation.

  2. Evolution and application of the competencies and educational milestones in physician graduate education in the United States

    Directory of Open Access Journals (Sweden)

    Ingrid Philibert

    2015-01-01

    The development of the milestones and initial testing by communities of practice in internal medicine, pediatrics, surgery, emergency medicine, neurological surgery and urology establishes the initial validity argument for the milestones. Further validity evidence will require study of the value of the milestones in assessment and accreditation, and linking educational outcomes to the performance and clinical outcomes of physicians in practice.

  3. ID brief news May/June

    CERN Multimedia

    Stapnes, S

    The SCT group passed an important milestone at the end of May when the barrel system was reviewed. Test-results of irradiated barrel hybrids and modules, and of a system of modules were presented. The noise levels in the system remain at a level similar to those measured for single modules. The efficiencies measured on single modules remain high even after irradiation to 3 x 1014 protons/cm2 corresponding to ten years of operation at the LHC. The SCT barrel community is now moving towards production with the SCT Frond End ASIC Production Readiness Review early July as the remaining step before all barrel module components are into full production. The modules consist of 4 silicon p,n detectors with 80um pitch, a thermal baseplate and a wrap-around hybrid bridged across the front and back of the module. The upper set of detectors on each module is rotated by 40mrad to provide stereo information. The picture shows 15 modules in the systemtest at CERN, mounted on a barrel structure. The four barrel productio...

  4. Analysis list: ID1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ID1 Digestive tract + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ID...1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ID1.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ID...1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ID1.Digestive_tract.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Digestive_tract.gml ...

  5. History of heat pumps - Swiss contributions and international milestones

    Energy Technology Data Exchange (ETDEWEB)

    Zogg, M.

    2008-05-15

    Compared to conventional boilers, heating by heat pumps cuts down fuel consumption and CO{sub 2} emissions to about 50%. Compared to electric resistance heating, the energy consumption is even reduced up to 80%. Therefore, the impressive market penetration growth of heat pumps will continue. Swiss pioneers were the first to realize functioning vapour recompression plants. The first European heat pumps were realized in Switzerland. To date it remains one of the heat pump champions. Swiss pioneering work in the development of borehole heat exchangers, sewage heat recovery, oil free piston compressors and turbo compressors is well known. The biggest heat pump ever built comes from Switzerland. Although there is a fairly comprehensive natural gas distribution grid, 75% of the new single-family homes built in Switzerland are currently heated by heat pumps. This paper presents some of the highlights of this success story focusing on Swiss developments and relating them to the international milestones. In order to indicate the direction in which the future development might go to, some recent Swiss research projects are presented as well. (author)

  6. History and milestones of mouse models of autoimmune diseases.

    Science.gov (United States)

    Yu, Xinhua; Huang, Qiaoniang; Petersen, Frank

    2015-01-01

    Autoimmune diseases are a group of disorders mediated by self-reactive T cells and/or autoantibodies. Mice, as the most widely used animal for modeling autoimmune disorders, have been extensively used in the investigation of disease pathogenesis as well as in the search for novel therapeutics. Since the first mouse model of multiple sclerosis was established more than 60 years ago, hundreds of mouse models have been established for tens of autoimmune diseases. These mouse models can be divided into three categories based on the approaches used for disease induction. The first one represents the induced models in which autoimmunity is initiated in mice by immunization, adoptive transfer or environmental factors. The second group is formed by the spontaneous models where mice develop autoimmune disorders without further induction. The third group refers to the humanized models in which mice bearing humanized cells, tissues, or genes, develop autoimmune diseases either spontaneously or by induction. This article reviews the history and highlights the milestones of the mouse models of autoimmune diseases.

  7. Geo-Informatics in India: Major Milestones and Present Scenario

    Science.gov (United States)

    Gupta, S.; Karnatak, H.; Raju, P. L. N.

    2016-06-01

    Geo-informatics has emerged globally as a useful tool to address spatial problems with significant societal implications that require integrative and innovative approaches for analysis, modelling, managing, and archiving of extensive and diverse data sets. Breakneck technological development and availability of satellite based data and information services in public domain along with real time geo-data n through participatory approaches, in the two last decades have led to a sea-change in our know-how of our natural resources and their effective management at various levels. It has led to a realization that every phenomena and requirement in our day to day life has some spatial, or geographic component that can be predicted and governed more effectively through geoinformatics tool. India also has come a long way in effective utilization of geoinformatics for various applications. This quantum leap owes its foundation in a humble beginning about half century back and almost parallel developments in the country's space programme to a current level where it touches almost all areas of life and living. Though geoinformatics technology (GIT) is believed to reach satisfactory level in the country, Indian geospatial community faces critical challenges with respect to research, education and training along with enhanced the access to the stakeholders and mobilization of the workforce, that are crucial in further penetration of this technology in context to India's development. In this paper we have critically reviewed milestones of GI development and its current utilization status in Indian context.

  8. Using motor milestones as a multistep process to screen preterm infants for cerebral palsy.

    Science.gov (United States)

    Allen, M C; Alexander, G R

    1997-01-01

    Pediatricians often informally use motor milestones to screen infant motor development, and one advantage is that they can be used during sequential office visits, as a multistep screening process. In this study we evaluated six motor milestones (roll prone to supine, roll supine to prone, sit with support, sit without support, crawl and cruise) as a multistep process in screening for cerebral palsy in 173 high-risk preterm infants (infants with delays in more than four motor milestones are referred for further evaluation and early intervention services.

  9. Id transcriptional regulators in adipogenesis and adipose tissue metabolism.

    Science.gov (United States)

    Patil, Mallikarjun; Sharma, Bal Krishan; Satyanarayana, Ande

    2014-06-01

    Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins are implicated in the regulation of various cellular mechanisms such as cell proliferation, cellular differentiation, cell fate determination, angiogenesis and tumorigenesis. A handful of recent studies also disclosed that Id proteins have critical functions in adipocyte differentiation and adipose tissue metabolism. Here, we reviewed the progress made thus far in understanding the specific functions of Id proteins in adipose tissue differentiation and metabolism. In addition to reviewing the known mechanisms of action, we also discuss possible additional mechanisms in which Id proteins might participate in regulating adipogenic and metabolic pathways.

  10. To ID or Not to ID? Changes in Classification Rates of Intellectual Disability Using "DSM-5"

    Science.gov (United States)

    Papazoglou, Aimilia; Jacobson, Lisa A.; McCabe, Marie; Kaufmann, Walter; Zabel, T. Andrew

    2014-01-01

    The "Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition" ("DSM-5") diagnostic criteria for intellectual disability (ID) include a change to the definition of adaptive impairment. New criteria require impairment in one adaptive domain rather than two or more skill areas. The authors examined the diagnostic…

  11. Low Physical Fitness Levels in Older Adults with ID: Results of the HA-ID Study

    Science.gov (United States)

    Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2012-01-01

    Physical fitness is as important to aging adults with ID as in the general population, but to date, the physical fitness levels of this group are unknown. Comfortable walking speed, muscle strength (grip strength), muscle endurance (30 s Chair stand) and cardiorespiratory endurance (10 m incremental shuttle walking test) were tested in a sample of…

  12. Low Physical Fitness Levels in Older Adults with ID: Results of the HA-ID Study

    Science.gov (United States)

    Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2012-01-01

    Physical fitness is as important to aging adults with ID as in the general population, but to date, the physical fitness levels of this group are unknown. Comfortable walking speed, muscle strength (grip strength), muscle endurance (30 s Chair stand) and cardiorespiratory endurance (10 m incremental shuttle walking test) were tested in a sample of…

  13. To ID or Not to ID? Changes in Classification Rates of Intellectual Disability Using "DSM-5"

    Science.gov (United States)

    Papazoglou, Aimilia; Jacobson, Lisa A.; McCabe, Marie; Kaufmann, Walter; Zabel, T. Andrew

    2014-01-01

    The "Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition" ("DSM-5") diagnostic criteria for intellectual disability (ID) include a change to the definition of adaptive impairment. New criteria require impairment in one adaptive domain rather than two or more skill areas. The authors examined the diagnostic…

  14. Milestone Age Affects the Role of Health and Emotions in Life Satisfaction: A Preliminary Inquiry.

    Directory of Open Access Journals (Sweden)

    Talya Miron-Shatz

    Full Text Available Jill turns 40. Should this change how she evaluates her life, and would a similar change occur when she turns 41? Milestone age (e.g., 30, 40, 50--a naturally occurring feature in personal timelines--has received much attention is popular culture, but little attention in academic inquiry. This study examines whether milestone birthdays change the way people evaluate their life. We show that life outlook is impacted by this temporal landmark, which appears to punctuate people's mental maps of their life cycle. At these milestone junctures, people take stock of where they stand and have a more evaluative perspective towards their lives when making life satisfaction judgments. Correspondingly, they place less emphasis on daily emotional experiences. We find that milestone agers (vs. other individuals place greater weight on health satisfaction and BMI and lesser weight on daily positive emotions in their overall life satisfaction judgments, whereas negative emotions remain influential.

  15. Milestone Age Affects the Role of Health and Emotions in Life Satisfaction: A Preliminary Inquiry

    Science.gov (United States)

    Miron-Shatz, Talya; Bhargave, Rajesh; Doniger, Glen M.

    2015-01-01

    Jill turns 40. Should this change how she evaluates her life, and would a similar change occur when she turns 41? Milestone age (e.g., 30, 40, 50)—a naturally occurring feature in personal timelines—has received much attention is popular culture, but little attention in academic inquiry. This study examines whether milestone birthdays change the way people evaluate their life. We show that life outlook is impacted by this temporal landmark, which appears to punctuate people’s mental maps of their life cycle. At these milestone junctures, people take stock of where they stand and have a more evaluative perspective towards their lives when making life satisfaction judgments. Correspondingly, they place less emphasis on daily emotional experiences. We find that milestone agers (vs. other individuals) place greater weight on health satisfaction and BMI and lesser weight on daily positive emotions in their overall life satisfaction judgments, whereas negative emotions remain influential. PMID:26244348

  16. Milestones in Software Engineering and Knowledge Engineering History: A Comparative Review

    Directory of Open Access Journals (Sweden)

    Isabel M. del Águila

    2014-01-01

    convergence or divergence of the software development methodologies. These milestones do not appear at the same time in software engineering and knowledge engineering, so lessons learned in one discipline can help in the evolution of the other one.

  17. DriveID: safety innovation through individuation.

    Science.gov (United States)

    Sawyer, Ben; Teo, Grace; Mouloua, Mustapha

    2012-01-01

    The driving task is highly complex and places considerable perceptual, physical and cognitive demands on the driver. As driving is fundamentally an information processing activity, distracted or impaired drivers have diminished safety margins compared with non- distracted drivers (Hancock and Parasuraman, 1992; TRB 1998 a & b). This competition for sensory and decision making capacities can lead to failures that cost lives. Some groups, teens and elderly drivers for example, have patterns of systematically poor perceptual, physical and cognitive performance while driving. Although there are technologies developed to aid these different drivers, these systems are often misused and underutilized. The DriveID project aims to design and develop a passive, automated face identification system capable of robustly identifying the driver of the vehicle, retrieve a stored profile, and intelligently prescribing specific accident prevention systems and driving environment customizations.

  18. Id2 deletion attenuates Apc-deficient ileal tumor formation

    Directory of Open Access Journals (Sweden)

    Kyoko Biyajima

    2015-08-01

    Full Text Available The expression level of inhibitor of DNA binding 2 (Id2 is increased in colorectal carcinomas and is positively correlated with poor prognosis. However, the functional significance of Id2 in intestinal tumorigenesis has not been fully defined using genetic approaches. Here, we show that Id2 promotes ileal tumor initiation in Apc-deficient mice. Expression of Id2 was stimulated by Wnt signaling through the enhancer region of the Id2 promoter at the early stage of tumorigenesis in Apc+/Δ716 (ApcΔ716 mice. Genetic depletion of Id2 in ApcΔ716 mice caused ∼80% reduction in the number of ileal polyps, but had little effect on tumor size. Notably, the lack of Id2 increased the number of apoptotic cells in the normal crypt epithelium of the mice. Furthermore, DNA microarray analysis revealed that the expression level of Max dimerization protein 1 (Mxd1, known as a c-Myc antagonist, was specifically increased by Id2 deletion in the ileal intestinal epithelium of ApcΔ716 mice. In contrast, the protein level of c-Myc, but not the mRNA level, was decreased by loss of Id2 in these mice. These results indicate that loss of Id2 inhibits tumor initiation by up-regulation of Mxd1 and down-regulation of c-Myc in ApcΔ716 mice.

  19. China's Lunar Exploration Program——The Third Milestone for China's Space Industry

    Institute of Scientific and Technical Information of China (English)

    Luan Enjie

    2006-01-01

    To explore the moon demonstrating the wisdom and capability of mankind. China's Lunar Exploration Program is the third milestone for China's space industry. We have formed China's lunar exploration program that features three milestones, i.e. "orbiting", "landing" and "returning". As a developing country, China conducts definite deep space activities under limited conditions, reflecting China's strong national strength and symbolizing ability of China's space industry.

  20. Early motor developmental milestones and schizophrenia: A systematic review and meta-analysis.

    Science.gov (United States)

    Filatova, S; Koivumaa-Honkanen, H; Hirvonen, N; Freeman, A; Ivandic, I; Hurtig, T; Khandaker, G M; Jones, P B; Moilanen, K; Miettunen, J

    2017-01-25

    The neurodevelopmental hypothesis of schizophrenia proposes that impaired brain development is a cause of the illness. Early motor developmental milestones, such as learning to walk, are predictors of later schizophrenia but studies have not been systematically reviewed. The aim of the present systematic review and meta-analysis was to explore the association between early motor developmental milestones and the risk of adult schizophrenia. In addition, we updated a systematic review on motor function and risk of schizophrenia. The PubMed, PsycINFO and Scopus databases were searched for original research articles published up to July 2015. Motor milestones were measured between ages 0 and 13years. Random effect meta-analysis calculated effect estimates (Hedges' g) for the association between individual motor milestones and schizophrenia risk. An electronic database and selected articles reference list search identified 5990 articles after removing duplicates. Sixty-nine full text articles were assessed for eligibility of which six were included in the review. Five studies provided sufficient data for meta-analyses. The following motor milestones were significantly associated with adult schizophrenia risk: walking unsupported (g=0.46; 95% CI 0.27-0.64; pmotor milestones in childhood and can contribute to the identification of individuals at risk of psychosis.

  1. Competency milestones for medical students: Design, implementation, and analysis at one medical school.

    Science.gov (United States)

    Lomis, Kimberly D; Russell, Regina G; Davidson, Mario A; Fleming, Amy E; Pettepher, Cathleen C; Cutrer, William B; Fleming, Geoffrey M; Miller, Bonnie M

    2017-05-01

    Competency-based assessment seeks to align measures of performance directly with desired learning outcomes based upon the needs of patients and the healthcare system. Recognizing that assessment methods profoundly influence student motivation and effort, it is critical to measure all desired aspects of performance throughout an individual's medical training. The Accreditation Council for Graduate Medical Education (ACGME) defined domains of competency for residency; the subsequent Milestones Project seeks to describe each learner's progress toward competence within each domain. Because the various clinical disciplines defined unique competencies and milestones within each domain, it is difficult for undergraduate medical education to adopt existing GME milestones language. This paper outlines the process undertaken by one medical school to design, implement and improve competency milestones for medical students. A team of assessment experts developed milestones for a set of focus competencies; these have now been monitored in medical students over two years. A unique digital dashboard enables individual, aggregate and longitudinal views of student progress by domain. Validation and continuous quality improvement cycles are based upon expert review, user feedback, and analysis of variation between students and between assessors. Experience to date indicates that milestone-based assessment has significant potential to guide the development of medical students.

  2. IEEE Milestone at CERN - W Cleon Anderson (right), president of the Institute of Electrical and Electronics Engineers, unveils the Milestone plaque at CERN, together with Georges Charpak

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    At a ceremony on 26 September at CERN, W Cleon Anderson, president of the Institute of Electrical and Electronics Engineers (IEEE), formally dedicated a "Milestone" plaque in recognition of the invention of electronic particle detectors at CERN. The plaque was unveiled by Anderson and Georges Charpak, the Nobel-prize winning inventor of wire-chamber technology at CERN.

  3. Memristor Crossbar-based Hardware Implementation of IDS Method

    OpenAIRE

    Merrikh-Bayat, Farnood; Bagheri-Shouraki, Saeed; Rohani, Ali

    2010-01-01

    Ink Drop Spread (IDS) is the engine of Active Learning Method (ALM), which is the methodology of soft computing. IDS, as a pattern-based processing unit, extracts useful information from a system subjected to modeling. In spite of its excellent potential in solving problems such as classification and modeling compared to other soft computing tools, finding its simple and fast hardware implementation is still a challenge. This paper describes a new hardware implementation of IDS method based o...

  4. Commissioning of the IDS Neutron Detector and $\\beta$-decay fast-timing studies at IDS

    CERN Document Server

    Piersa, Monika

    2016-01-01

    The following report describes my scientific activities performed during the Summer Student Programme at ISOLDE. The main part of my project was focused on commissioning the neutron detector dedicated to nuclear decay studies at ISOLDE Decay Station (IDS). I have participated in all the steps needed to make it operational for the IS609 experiment. In the testing phase, we obtained expected detector response and calibrations confirmed its successful commissioning. The detector was mounted in the desired geometry at IDS and used in measurements of the beta-delayed neutron emission of $^8$He. After completing aforementioned part of my project, I became familiar with the fast-timing method. This technique was applied at IDS in the IS610 experiment performed in June 2016 to explore the structure of neutron-rich $^{130-134}$Sn nuclei. Since the main part of my PhD studies will be the analysis of data collected in this experiment, the second part of my project was dedicated to acquiring knowledge about technical de...

  5. Milestones in the Observations of Cosmic Magnetic Fields

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Magnetic fields are observed everywhere in the universe. In this review,we concentrate on the observational aspects of the magnetic fields of Galactic and extragalactic objects. Readers can follow the milestones in the observations of cosmic magnetic fields obtained from the most important tracers of magnetic fields,namely, the star-light polarization, the Zeeman effect, the rotation measures (RMs,hereafter) of extragalactic radio sources, the pulsar RMs, radio polarization observations, as well as the newly implemented sub-mm and mm polarization capabilities.The magnetic field of the Galaxy was first discovered in 1949 by optical polarization observations. The local magnetic fields within one or two kpc have been well delineated by starlight polarization data. The polarization observations of diffuse Galactic radio background emission in 1962 confirmed unequivocally the existence of a Galactic magnetic field. The bulk of the present information about the magnetic fields in the Galaxy comes from analysis of rotation measures of extragalactic radio sources and pulsars, which can be used to construct the 3-D magnetic field structure in the Galactic halo and Galactic disk. Radio synchrotron spurs in the Galactic center show a poloidal field, and the polarization mapping of dust emission and Zeeman observation in the central molecular zone reveal a toroidal magnetic field parallel to the Galactic plane. For nearby galaxies, both optical polarization and multifrequency radio polarization data clearly show the large-scale magnetic field following the spiral arms or dust lanes. For more distant objects, radio polarization is the only approach available to show the magnetic fields in the jets or lobes of radio galaxies or quasars. Clusters of galaxies also contain widely distributed magnetic fields, which are reflected by radio halos or the RM distribution of background objects. The intergalactic space could have been magnetized by outflows or galactic superwinds even in

  6. Achievement of feeding milestones after primary repair of long-gap esophageal atresia.

    Science.gov (United States)

    Khan, Khalid M; Krosch, Tara C; Eickhoff, Jeffrey C; Sabati, Arash A; Brudney, James; Rivard, Andrew L; Foker, John E

    2009-06-01

    To determine the pattern of feeding milestones following primary repair of long-gap esophageal atresia (EA). A questionnaire based upon well established feeding milestones was used. Children after long-gap EA repair, n=40, were compared from after primary repair to healthy children from birth, n=102. The age when surveyed of the EA group and controls was different: 6.2+/-4.7 (mean+/-standard deviation) years, range 1.1-20.9, versus 2.5+/-2.4 years, range 0.0-12.1, p=0.00. The esophageal gap length in the EA group was 5.1+/-1.2 cm and age at repair was 5.5+/-5.0 months. There was no statistically significant difference between the atresia group and controls for feeding milestones; Self feeding finger foods approached significance. There was, however, greater variability in the timing of milestones in the atresia group compared to controls. Feeding milestones were negatively correlated with age at primary repair: drinking with a covered sippy cup, rho=-0.51, p=0.01 and self feeding finger foods, rho=-0.36, p=0.04 were statistically significant. Drinking from a cup correlated with gestational age, rho=0.38, p=0.04, and negatively correlated to esophageal gap length, rho=-0.45, p=0.01. Despite delayed onset of feeding, major milestones after EA repair occurred in similar pattern to normal infants. An early referral for primary repair is beneficial for earlier acquisition of milestones for infants with long-gap EA.

  7. A Contextual Model for Identity Management (IdM) Interfaces

    Science.gov (United States)

    Fuller, Nathaniel J.

    2014-01-01

    The usability of Identity Management (IdM) systems is highly dependent upon design that simplifies the processes of identification, authentication, and authorization. Recent findings reveal two critical problems that degrade IdM usability: (1) unfeasible techniques for managing various digital identifiers, and (2) ambiguous security interfaces.…

  8. Evaluation of the chromogenic agar chromID C. difficile.

    Science.gov (United States)

    Eckert, Catherine; Burghoffer, Béatrice; Lalande, Valérie; Barbut, Frederic

    2013-03-01

    Three selective media (chromID C. difficile agar, taurocholate cycloserine cefoxitin agar [TCCA; homemade], and CLO medium) were compared from 406 stool samples of patients suspected of having Clostridium difficile infection. The sensitivities of chromID C. difficile agar at 24 h and 48 h, CLO medium, and TCCA were 74.1%, 87%, 85.2%, and 70.4%, respectively.

  9. Evaluation of the Chromogenic Agar chromID C. difficile

    OpenAIRE

    2013-01-01

    Three selective media (chromID C. difficile agar, taurocholate cycloserine cefoxitin agar [TCCA; homemade], and CLO medium) were compared from 406 stool samples of patients suspected of having Clostridium difficile infection. The sensitivities of chromID C. difficile agar at 24 h and 48 h, CLO medium, and TCCA were 74.1%, 87%, 85.2%, and 70.4%, respectively.

  10. ID Model Construction and Validation: A Multiple Intelligences Case

    Science.gov (United States)

    Tracey, Monica W.; Richey, Rita C.

    2007-01-01

    This is a report of a developmental research study that aimed to construct and validate an instructional design (ID) model that incorporates the theory and practice of multiple intelligences (MI). The study consisted of three phases. In phase one, the theoretical foundations of multiple Intelligences and ID were examined to guide the development…

  11. Evaluation of ID-PaGIA syphilis antibody test.

    Science.gov (United States)

    Naaber, Paul; Makoid, Ene; Aus, Anneli; Loivukene, Krista; Poder, Airi

    2009-01-01

    Laboratory diagnosis of syphilis is usually accomplished by serology. There are currently a large number of different commercial treponemal tests available that vary in format, sensitivity and specificity. To evaluate the ID-PaGIA Syphilis Antibody Test as an alternative to other specific treponemal tests for primary screening or confirmation of diagnosis. Serum samples from healthy adults (n = 100) were used for detection of specificity of ID-PaGIA. To evaluate sensitivity of ID-PaGIA serum samples (n = 101) from patients with confirmed or suspected syphilis were tested for syphilis antibodies with FTA-Abs IgM, ID-PaGIA, ELISA IgM and TPHA tests. No false-positive results were found with ID-PaGIA. Sensitivity of various treponemal tests was the following: FTA-Abs IgM: 95.5%, ID-PaGIA and ELISA IgM: 94%, and TPHA 75%. The positive and negative predictive values of ID-PaGIA were 100 and 89.5%, respectively. Compared with other treponemal tests ID-PaGIA has excellent sensitivity and specificity.

  12. The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site

    DEFF Research Database (Denmark)

    Babakhanyan, Anna; Leke, Rose G F; Salanti, Ali;

    2014-01-01

    antigens, malarial antigens, or microbes. Currently, ID1-ID2a is a leading vaccine candidate, since it binds to the CSA with the same affinity as the full-length molecule and elicits binding-inhibitory antibodies in animals. Further studies are needed to determine if the presence of naturally acquired...... cross-reactive antibodies in women living in malaria endemic countries will alter the response to ID1-ID2a following vaccination with ID1-ID2a....

  13. Extending and implementing the Persistent ID pillars

    Science.gov (United States)

    Car, Nicholas; Golodoniuc, Pavel; Klump, Jens

    2017-04-01

    The recent double decade anniversary of scholarly persistent identifier use has triggered journal special editions such as "20 Years of Persistent Identifiers". For such a publication, it is apt to consider the longevity of some persistent identifier (PID) mechanisms (Digital Object Identifiers) and the partial disappearance of others (Life Sciences IDs). We have previously postulated a set of "PID Pillars" [1] which are design principles aimed at ensuring PIDs can survive technology and social change and thus persist for the long term that we have drawn from our observations of PIDs at work over many years. The principles: describe how to ensure identifiers' system and organisation independence; codify the delivery of essential PID system functions; mandate a separation of PID functions from data delivery mechanisms; and require generation of policies detailing how change is handled. In this presentation, first we extend on our previous work of introducing the pillars by refining their descriptions, giving specific suggestions for each and presenting some work that addresses them. Second, we propose a baseline data model for persistent identifiers that, if used, would assist the separation of PID metadata and PID system functioning. This would allow PID system function specifics to change over time (e.g. resolver services or even resolution protocols) and yet preserve the PIDs themselves. Third, we detail our existing PID system — the PID Service [2] — that partially implements the pillars and describe both its successes and shortcomings. Finally, we describe our planned next-generation system that will aim to use the baseline data model and fully implement the pillars.

  14. Classification of artificial intelligence ids for smurf attack

    CERN Document Server

    Ugtakhbayar, N; Sodbileg, Sh

    2012-01-01

    Many methods have been developed to secure the network infrastructure and communication over the Internet. Intrusion detection is a relatively new addition to such techniques. Intrusion detection systems (IDS) are used to find out if someone has intrusion into or is trying to get it the network. One big problem is amount of Intrusion which is increasing day by day. We need to know about network attack information using IDS, then analysing the effect. Due to the nature of IDSs which are solely signature based, every new intrusion cannot be detected; so it is important to introduce artificial intelligence (AI) methods / techniques in IDS. Introduction of AI necessitates the importance of normalization in intrusions. This work is focused on classification of AI based IDS techniques which will help better design intrusion detection systems in the future. We have also proposed a support vector machine for IDS to detect Smurf attack with much reliable accuracy.

  15. Expression of Id2 in the Second Heart Field and Cardiac Defects in Id2 Knock-Out Mice

    NARCIS (Netherlands)

    Jongbloed, M. R. M.; Vicente-Steijn, R.; Douglas, Y. L.; Wisse, L. J.; Mori, K.; Yokota, Y.; Bartelings, M. M.; Schalij, M. J.; Mahtab, E. A.; Poelmann, R. E.; Gittenberger-De Groot, A. C.

    2011-01-01

    The inhibitor of differentiation Id2 is expressed in mesoderm of the second heart field, which contributes myocardial and mesenchymal cells to the primary heart tube. The role of Id2 in cardiac development is insufficiently known. Heart development was studied in sequential developmental stages in I

  16. Migration to Risk Spectrum PSA Level 2 internal events

    Energy Technology Data Exchange (ETDEWEB)

    Crusells Girona, M.

    2012-07-01

    The paper is part of the APS model development level 2 internal events. According to the Spanish regulatory requirements and especially the recent safety instruction IS-25, Level 2 models are becoming increasingly important within the probabilistic safety analysis of the Spanish nuclear power plants, thus requiring accurate and efficient implementation such models, together with a systematic analysis thereof.

  17. Modeling kinetics and equilibrium of membranes with fields: Milestoning analysis and implication to permeation

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas, Alfredo E. [Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas 78712 (United States); Elber, Ron [Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas 78712 (United States); Department of Chemistry, University of Texas at Austin, Austin, Texas 78712 (United States)

    2014-08-07

    Coarse graining of membrane simulations by translating atomistic dynamics to densities and fields with Milestoning is discussed. The space of the membrane system is divided into cells and the different cells are characterized by order parameters presenting the number densities. The dynamics of the order parameters are probed with Milestoning. The methodology is illustrated here for a phospholipid membrane system (a hydrated bilayer of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) lipid molecules). Significant inhomogeneity in membrane internal number density leads to complex free energy landscape and local maps of transition times. Dynamics and distributions of cavities within the membrane assist the permeation of nonpolar solutes such as xenon atoms. It is illustrated that quantitative and detailed dynamics of water transport through DOPC membrane can be analyzed using Milestoning with fields. The reaction space for water transport includes at least two slow variables: the normal to the membrane plane, and the water density.

  18. Immunization Milestones: A More Comprehensive Picture of Age-Appropriate Vaccination

    Directory of Open Access Journals (Sweden)

    Steve G. Robison

    2010-01-01

    Full Text Available A challenge facing immunization registries is developing measures of childhood immunization coverage that contain more information for setting policy than present vaccine series up-to-date (UTD rates. This study combined milestone analysis with provider encounter data to determine when children either do not receive indicated immunizations during medical encounters or fail to visit providers. Milestone analysis measures immunization status at key times between birth and age 2, when recommended immunizations first become late. The immunization status of a large population of children in the Oregon ALERT immunization registry and in the Oregon Health Plan was tracked across milestone ages. Findings indicate that the majority of children went back and forth with regard to having complete age-appropriate immunizations over time. We also found that immunization UTD rates when used alone are biased towards relating non-UTD status to a lack of visits to providers, instead of to provider visits on which recommended immunizations are not given.

  19. 2016 CSSE L3 Milestone: Deliver In Situ to XTD End Users

    Energy Technology Data Exchange (ETDEWEB)

    Patchett, John M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Nouanesengsy, Boonthanome [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fasel, Patricia Kroll [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ahrens, James Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-13

    This report summarizes the activities in FY16 toward satisfying the CSSE 2016 L3 milestone to deliver in situ to XTD end users of EAP codes. The Milestone was accomplished with ongoing work to ensure the capability is maintained and developed. Two XTD end users used the in situ capability in Rage. A production ParaView capability was created in the HPC and Desktop environment. Two new capabilities were added to ParaView in support of an EAP in situ workflow. We also worked with various support groups at the lab to deploy a production ParaView in the LANL environment for both desktop and HPC systems. . In addition, for this milestone, we moved two VTK based filters from research objects into the production ParaView code to support a variety of standard visualization pipelines for our EAP codes.

  20. Idéologie : le mot, l’idée, la chose.

    Directory of Open Access Journals (Sweden)

    Pierre Macherey

    2008-04-01

    Full Text Available L’article examine les conditions dans lesquelles le néologisme « idéologie », entre 1796, date à laquelle il a été forgé par Destutt de Tracy, et 1845, date à laquelle il a été réutilisé par Marx, est passé d’une valeur positive (en tant que science générale des idées à une valeur connotée négativement (en tant que système social de croyances décalé par rapport à la réalité qu’il évoque.« Ideology : the word, the idea, the thing ». This paper studies the transvaluation of “ideology” as a neologism. Between 1796 (when the notion of “ideology” was invented by Destutt de Tracy and 1845 (when it was reused by Marx, “ideology” changed its positive value (it refers to a general science of ideas into a negative one (because it was referred to a social system of believes, shifted from the reality it mentions.

  1. NORMA PERKEMBANGAN MOTOR MILESTONE ANAK SEHAT DAN BERGIZI BAIK DALAM RANGKA PENGEMBANGAN SUATU RUJUKAN

    Directory of Open Access Journals (Sweden)

    Abas B. Jahari

    2012-11-01

    Full Text Available Norm of Motor Milestone Achievements In Healthy and Well Nourished Children Leading To The Development A Reference.Background: The prevalence of malnutrition is still high in Indonesia, and one of its functional consequences is level of the intelectual capacity of children. Motor development is an essential of cognitive performance, and it is generally believed related with nutritional status of children, however very few studies had been carried out in the field condition.Objectlves: To describe the ceiling of motor milestone achievements of healthy and well nourished children aged 3-18 months in the development of norms for Indonesian children.Methods: The study was conducted in 4 big cities: Surabaya, Malang, Bandung and Bogor in 2100 healthy and well nourished children aged 3-18 months came from high SES (socio-economic status families who had no constraints on achieving normal growth and development. There were 17 milestones observed by well trainned enumerators following standard procedure. Analysis of percentiles 5, 10, 50, 90, and 95 for age against motor achievement were carried out for all children.Results: The difference in the attainment of the ceiling of motor milestones between males and females were not significant at any points of observation, therefore sex combined norm curve of motor development for children aged 3-18 months was ilustrated.Conclusions: The norm of motor milestone development for Indonesian children aged 3-18 months has been developed. Before being used as a reference, it needs to be evaluated or it is reliability and feasibility.Keywords: motor milestone, motor development, reference of motor development.

  2. Early motor developmental milestones and level of neuroticism in young adulthood

    DEFF Research Database (Denmark)

    Flensborg-Madsen, T; Sørensen, H J; Revsbech, Rasmus

    2013-01-01

    Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personalit...... analysed by multiple linear regression adjusting for for sex, single-mother status, parity, mother's age, father's age, parental social status and birth weight....... traits is almost non-existent. This study is therefore the first to investigate associations between early motor developmental milestones and neuroticism in adulthood. Method Mothers of 9125 children of the Copenhagen Perinatal Cohort recorded 12 developmental milestones during the child's first year...

  3. Biometric authentication for ID cards with hologram watermarks

    Science.gov (United States)

    Croce Ferri, Lucilla; Mayerhoefer, Astrid; Frank, Marcus; Vielhauer, Claus; Steinmetz, Ralf

    2002-04-01

    We present an analysis of a new technique for the authentication of ID cardholders, based on the integration of a biometrics-based authentication system with digital watermarks. The chosen biometric authentication method is the dynamic signature verification of the ID cardholder, while we use a specific integrity watermark technique we developed, called Hologram Watermark, to embed and retrieve the off-line data onto an ID card. We take advantage of the fact, that two static biometric features (images of the user's face and signature) are already integral part of ID cards for manual verification and extent the stored biometric information by embedding on-line handwriting features of the signature as holographic watermarks in the overall image information of an ID card. Manipulation of any of the image information can be detected and will further disallow biometric verification of the forger. The Hologram Watermark technique produces content-related data using computer-generated hologram coding techniques. These data are embedded with watermarking techniques into the personal data printed on an ID card. The content-related data in this specific application are the dynamic features of the cardholder's signature. The main goal of this paper is to analyze the suitability of dynamic signature verification in combination with the Hologram Watermark technique, to facilitate automated user authentication based on information transparently embedded in ID cards.

  4. Improved ID-Based Signature Scheme Solving Key Escrow

    Institute of Scientific and Technical Information of China (English)

    LIAO Jian; QI Ying-hao; HUANG Pei-wei; RONG Men-tian; LI Sheng-hong

    2006-01-01

    Key escrow is an inherent disadvantage for traditional ID-based cryptosystem, i.e. , the dishonest private key generator (PKG) can forge the signature of any user, meanwhile, the user can deny the signature actually signed by him/herself. To avoid the keyescrow problem, an ID-based signature scheme was presented without trusted PKG. The exact proof of security was presented to demonstrate that our scheme is secure against existential forgery on adaptively chosen message and ID attacks assuming the complexity of computational Diffie-Hellman(CDH) problem. Compared with other signature schemes, the proposed scheme is more efficient.

  5. Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Desprez, Pierre-Yves; Campisi, Judith

    2014-09-30

    A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

  6. Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    Science.gov (United States)

    Desprez, Pierre-Yves; Campisi, Judith

    2014-09-30

    A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

  7. Lowest-ID with Adaptive ID Reassignment: A Novel Mobile Ad-Hoc Networks Clustering Algorithm

    CERN Document Server

    Gavalas, Damianos; Konstantopoulos, Charalampos; Mamalis, Basilis

    2011-01-01

    Clustering is a promising approach for building hierarchies and simplifying the routing process in mobile ad-hoc network environments. The main objective of clustering is to identify suitable node representatives, i.e. cluster heads (CHs), to store routing and topology information and maximize clusters stability. Traditional clustering algorithms suggest CH election exclusively based on node IDs or location information and involve frequent broadcasting of control packets, even when network topology remains unchanged. More recent works take into account additional metrics (such as energy and mobility) and optimize initial clustering. However, in many situations (e.g. in relatively static topologies) re-clustering procedure is hardly ever invoked; hence initially elected CHs soon reach battery exhaustion. Herein, we introduce an efficient distributed clustering algorithm that uses both mobility and energy metrics to provide stable cluster formations. CHs are initially elected based on the time and cost-efficien...

  8. 20 CFR 411.566 - May an EN use outcome or milestone payments to make payments to the beneficiary?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false May an EN use outcome or milestone payments to make payments to the beneficiary? 411.566 Section 411.566 Employees' Benefits SOCIAL SECURITY... an EN use outcome or milestone payments to make payments to the beneficiary? Yes, an EN may...

  9. 20 CFR 411.580 - Can an EN receive payments for milestones or outcome payment months that occur before the...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Can an EN receive payments for milestones or outcome payment months that occur before the beneficiary assigns a ticket to the EN? 411.580 Section 411... Employment Network Payment Systems § 411.580 Can an EN receive payments for milestones or outcome...

  10. 20 CFR 411.575 - How does the EN request payment for milestones or outcome payment months achieved by a...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How does the EN request payment for milestones or outcome payment months achieved by a beneficiary who assigned a ticket to the EN? 411.575... PROGRAM Employment Network Payment Systems § 411.575 How does the EN request payment for milestones...

  11. 20 CFR 411.560 - Is it possible to pay a milestone or outcome payment to more than one EN?

    Science.gov (United States)

    2010-04-01

    ... payment to more than one EN? 411.560 Section 411.560 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... possible to pay a milestone or outcome payment to more than one EN? It is possible for more than one EN (including a State VR agency acting as an EN) to receive payment based on the same milestone or outcome....

  12. From Kissing to Coitus? Sex-of-Partner Differences in the Sexual Milestone Achievement of Young Men

    Science.gov (United States)

    Smiler, Andrew P.; Frankel, Loren B. W.; Savin-Williams, Ritch C.

    2011-01-01

    Scientific information regarding normative patterns of young men's sexual behavior is insufficient, especially regarding the impact of sex of partner. We explored the age at which 255 young adult men achieved several milestones (e.g., first kiss, manual-genital contact, intercourse) as well as the sequence of milestone achievement and stability in…

  13. MISR Level 2 TOA/Cloud Stereo parameters V002

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 TOA/Cloud Stereo Product. It contains the Stereoscopically Derived Cloud Mask (SDCM), cloud winds, Reflecting Level Reference Altitude (RLRA),...

  14. MISR Level 2 FIRSTLOOK Aerosol parameters V001

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 FIRSTLOOK Aerosol Product. It contains Aerosol optical depth and particle type, with associated atmospheric data, produced using ancillary inputs...

  15. MISR Level 2 FIRSTLOOK Surface parameters V001

    Data.gov (United States)

    National Aeronautics and Space Administration — This Level 2 FIRSTLOOK Land Surface product contains directional reflectance properties,albedo(spectral to study, on a global basis,the magnitude and natural...

  16. NASA GES DISC Level 2 Aerosol Analysis and Visualization Services

    Science.gov (United States)

    Wei, Jennifer; Petrenko, Maksym; Ichoku, Charles; Yang, Wenli; Johnson, James; Zhao, Peisheng; Kempler, Steve

    2015-01-01

    Overview of NASA GES DISC Level 2 aerosol analysis and visualization services: DQViz (Data Quality Visualization)MAPSS (Multi-sensor Aerosol Products Sampling System), and MAPSS_Explorer (Multi-sensor Aerosol Products Sampling System Explorer).

  17. MISR Level 2 TOA/Cloud Classifier parameters V003

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 TOA/Cloud Classifiers Product. It contains the Angular Signature Cloud Mask (ASCM), Regional Cloud Classifiers, Cloud Shadow Mask, and...

  18. GPM, GMI Level 2A Radiometer Profiling VV03C

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  19. Role of yeast domination in Indian idli batter fermentation.

    Science.gov (United States)

    Soni, S K; Sandhu, D K

    1991-07-01

    Adding Saccharomyces cerevisiae, along with natural bacterial flora of the ingredients, was the best method for standardizing idli termentation in terms of improved organoleptic characteristics, leavening and nutritional constituents.

  20. Defining the safe current limit for opening ID photon shutter

    Energy Technology Data Exchange (ETDEWEB)

    Seletskiy, S. [Brookhaven National Lab. (BNL), Upton, NY (United States). Photon Sciences Dept.

    2015-12-14

    The NSLS-II storage ring is protected from possible damage from insertion devices (IDs) synchrotron radiation by a dedicated active interlock system (AIS). It monitors electron beam position and angle and triggers beam drop if beam orbit exceeds the boundaries of pre-calculated active interlock envelope (AIE). The beamlines (BL) and beamline frontends (FE) are designed under assumption that the electron beam is interlocked within the AIE. For historic reasons the AIS engages the ID active interlock (AI-ID) at any non-zero beam current whenever the ID photon shutter (IDPS) is getting opened. Such arrangement creates major inconveniences for BLs commissioning. Apparently there is some IDPS safe current limit (SCL) under which the IDPS can be opened without interlocking the e-beam. The goal of this paper is to find such limit.

  1. Scientists ID Key Fetal Cells Vulnerable to Zika

    Science.gov (United States)

    ... html Scientists ID Key Fetal Cells Vulnerable to Zika Lab study suggests possible mechanism for birth defects ... 29, 2016 (HealthDay News) -- The devastating mosquito-borne Zika virus can infect cells that play a role ...

  2. A Good IDS Response Protocol of MANET Containment Strategies

    Science.gov (United States)

    Cheng, Bo-Chao; Chen, Huan; Tseng, Ryh-Yuh

    Much recent research concentrates on designing an Intrusion Detection System (IDS) to detect the misbehaviors of the malicious node in MANET with ad-hoc and mobility natures. However, without rapid and appropriate IDS response mechanisms performing follow-up management services, even the best IDS cannot achieve the desired primary goal of the incident response. A competent containment strategy is needed to limit the extent of an attack in the Incident Response Life Cycle. Inspired by the T-cell mechanisms in the human immune system, we propose an efficient MANET IDS response protocol (T-SecAODV) that can rapidly and accurately disseminate alerts of the malicious node attacks to other nodes so as to modify their AODV routing tables to isolate the malicious nodes. Simulations are conducted by the network simulator (Qualnet), and the experiment results indicate that T-SecAODV is able to spread alerts steadily while greatly reduce faulty rumors under simultaneous multiple malicious node attacks.

  3. Genetics Experts Unite to I.D. Unknown Katrina Victims

    Science.gov (United States)

    ... Current Issue Past Issues Research News From NIH Genetics Experts Unite to I.D. Unknown Katrina Victims ... in the recent Advances in molecular biology and genetics," says team member Stephen Sherry, Ph.D., of ...

  4. FDIC Institution Directory (ID) -- Insured Insitution Download File

    Data.gov (United States)

    Federal Deposit Insurance Corporation — The FDIC's Institution Directory (ID) download file provides a list of all FDIC-insured institutions. The file includes demographic information related to the...

  5. idSpace: Supporting Designers to develop Innovative Products

    NARCIS (Netherlands)

    Sloep, Peter; Bitter-Rijpkema, Marlies; Retalis, Symeon; Georgiakakis, Petros; Dolog, Peter

    2009-01-01

    Sloep, P., Bitter-Rijpkema, M., Retalis, S., Georgiakakis, P., & Dolog, P. (2008). idSpace: Supporting Designers to develop Innovative Products. Presentation at Online Educa. December, 3, 2008. Berlin, Germany.

  6. Security analysis for biometric data in ID documents

    Science.gov (United States)

    Schimke, Sascha; Kiltz, Stefan; Vielhauer, Claus; Kalker, Ton

    2005-03-01

    In this paper we analyze chances and challenges with respect to the security of using biometrics in ID documents. We identify goals for ID documents, set by national and international authorities, and discuss the degree of security, which is obtainable with the inclusion of biometric into documents like passports. Starting from classical techniques for manual authentication of ID card holders, we expand our view towards automatic methods based on biometrics. We do so by reviewing different human biometric attributes by modality, as well as by discussing possible techniques for storing and handling the particular biometric data on the document. Further, we explore possible vulnerabilities of potential biometric passport systems. Based on the findings of that discussion we will expand upon two exemplary approaches for including digital biometric data in the context of ID documents and present potential risks attack scenarios along with technical aspects such as capacity and robustness.

  7. Study IDs 2 Zika Virus Proteins Linked to Microcephaly

    Science.gov (United States)

    ... gov/news/fullstory_160386.html Study IDs 2 Zika Virus Proteins Linked to Microcephaly Discovery might one day ... say they've identified two proteins in the Zika virus linked to the severe birth defect microcephaly. Babies ...

  8. Narva Aleksandri kirikusse paigaldatakse vitraažid / Irina Tokareva

    Index Scriptorium Estoniae

    Tokareva, Irina

    2004-01-01

    1919.a. hävinud vitraažid asendatakse Dolores Hoffmanni originaalsete piiblipersoone kujutavate vitraažidega. Kasutatakse uudset tehnoloogiat. vitraaže on kiriku kaheksa akna jaoks. Villu Jürjo kommentaarid

  9. RadNet Air Data From Idaho Falls, ID

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Idaho Falls, ID from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  10. Biometrics and ID Cards — Enablers for Personal Security

    Science.gov (United States)

    Reisen, Andreas

    The electronic ID card is a modernization and security project of the German Government. On the one hand, the multifunctional card is intended to boost security and the convenience of e-government and e-business applications. On the other hand, the new biometric ID card should allow citizens to use it as a travel document in the Schengen area and for specific destinations outside the European Union also in the future.

  11. Failure to meet language milestones at two years of age is predictive of specific language impairment

    NARCIS (Netherlands)

    Diepeveen, F.B.; Dusseldorp, E.; Bol, G.W.; Oudesluys-Murphy, A.M.; Verkerk, P.H.

    2016-01-01

    Aim This study established predictive properties of single language milestones for specific language impairment (SLI) after the age of four, as these had not previously been reported in the literature. Methods In this nested case-control study, children attending special needs schools for severe spe

  12. Failure to meet language milestones at two years of age is predictive of specific language impairment

    NARCIS (Netherlands)

    Diepeveen, Babette; Dusseldorp, Elise; Bol, Gerard; Oudesluys-Murphy, Anne Marie; Verkerk, Paul

    2015-01-01

    Aim This study established predictive properties of single language milestones for specific language impairment (SLI) after the age of four, as these had not previously been reported in the literature. Methods In this nested case–control study, children attending special needs schools for severe spe

  13. Relations of Alcohol Consumption with Smoking Cessation Milestones and Tobacco Dependence

    Science.gov (United States)

    Cook, Jessica W.; Fucito, Lisa M.; Piasecki, Thomas M.; Piper, Megan E.; Schlam, Tanya R.; Berg, Kristin M.; Baker, Timothy B.

    2012-01-01

    Objective: Alcohol consumption is associated with smoking cessation failure in both community and clinical research. However, little is known about the relation between alcohol consumption and smoking cessation milestones (i.e., achieving initial abstinence, avoiding lapses and relapse). Our objective in this research was to examine the relations…

  14. Outcomes and milestone achievement differences for very low-birth-weight multiples compared with singleton infants.

    Science.gov (United States)

    Kirkby, Sharon; Genen, Linda; Turenne, Wendy; Dysart, Kevin

    2010-06-01

    We examined if very low-birth-weight (VLBW) infants of multiple gestation pregnancies experience more complications and take longer to achieve clinical milestones compared with similar singletons. We performed a retrospective analysis of all infants less than 1500 g at birth in a large neonatal database. Singletons were compared with twins and higher-order multiples for demographic, morbidities, and process milestones including feeding, respiratory, thermoregulation, and length of stay. Multivariable regression analyses were performed to control for potential confounding variables. A total of 5507 infants were included: 3792 singletons, 1391 twins, and 324 higher-order multiples. There were no differences in Apgar scores, small for gestational age status, and incidence of necrotizing enterocolitis, severe retinopathy of prematurity, severe intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, or the need for surgery. Multiples had higher rates of apnea and patent ductus arteriosus than singletons. VLBW multiples achieved milestones at similar rates in most areas compared with singletons except for the achievement of full oral feedings. Length of stay, after controlling for confounding variables, did not differ between the groups. Compared with singletons, VLBW multiples had similar morbidity and achieved most feeding and thermoregulation milestones at similar rates.

  15. Effects of Family and Friend Support on LGB Youths' Mental Health and Sexual Orientation Milestones

    Science.gov (United States)

    Shilo, Guy; Savaya, Riki

    2011-01-01

    This study examined the effects of social support components and providers on mental health and sexual orientation (SO) milestones of lesbian, gay, and bisexual (LGB) youths. Data were collected on 461 self-identified LGB adolescents and young adults. Family acceptance and support yielded the strongest positive effect on self-acceptance of SO,…

  16. Veterans' Gathering for Choosing Milestone-makers in the 60 Years' DEVELOPMENT OF SHIPPING INDUSTRY

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ The two-day Symposium on the Milestone-Makers in China's 60 Years of Shipping Industry was convened as planned in the beautiful ancient town of ZhuJiajiao in Shanghai.Over 30 authorities attended the symposium including the former Minister of Communications and current Chairman of China Communications and Transportation Association(CCTA)Mr.

  17. Motor Milestone Development in Young Children with Autism Spectrum Disorders: An Exploratory Study

    Science.gov (United States)

    Liu, Ting

    2012-01-01

    This study aimed to determine if a sample of children currently diagnosed with autism spectrum disorders (ASDs) would have shown motor milestone delays before age three as compared to typically developing children. Given delays in motor skills, the study also strived to determine which specific skills might be delayed. Parents of 44 children who…

  18. 32 CFR 37.575 - What are my responsibilities for determining milestone payment amounts?

    Science.gov (United States)

    2010-07-01

    ... SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Accounting, Payments, and Recovery of Funds § 37.575 What are my responsibilities for determining... needs for carrying out that phase of the research effort. (b) The Federal share at each milestone need...

  19. Accelerated fermentation of 'idli' batter using soy residue okara.

    Science.gov (United States)

    Rekha, C R; Vijayalakshmi, G

    2011-06-01

    The aim of this work was to reduce the natural fermentation period of 'idli' from the conventional 14 h to 10 h by adding underutilized okara for the preparation of 'idli'. Black gram was partially substituted with soy residue okara in the ratio of (1:1). After 14 h of natural fermentation, the pH and total acidity of control 'idli' batter was 4.51 and 0.64% and that of okara fortified 'idli' batter was 4.53 and 0.43%, respectively. The amount of CO2 released by the control and okara fortified batter was 19.7% and 33.6% respectively. The viable count of yeast and mold, lactics and mesophilic bacteria in control & okara batter increased with time reaching 9.00 & 10.34, 8.66 & 7.69, and 8.65 & 9.47 log10 cfu/g, respectively at the end of 10 h of natural fermentation. Okara fortified 'idli' was soft and spongy compared to control 'idli' .

  20. BioID Identification of Lamin-Associated Proteins.

    Science.gov (United States)

    Mehus, Aaron A; Anderson, Ruthellen H; Roux, Kyle J

    2016-01-01

    A- and B-type lamins support the nuclear envelope, contribute to heterochromatin organization, and regulate a myriad of nuclear processes. The mechanisms by which lamins function in different cell types and the mechanisms by which lamin mutations cause over a dozen human diseases (laminopathies) remain unclear. The identification of proteins associated with lamins is likely to provide fundamental insight into these mechanisms. BioID (proximity-dependent biotin identification) is a unique and powerful method for identifying protein-protein and proximity-based interactions in living cells. BioID utilizes a mutant biotin ligase from bacteria that is fused to a protein of interest (bait). When expressed in living cells and stimulated with excess biotin, this BioID-fusion protein promiscuously biotinylates directly interacting and vicinal endogenous proteins. Following biotin-affinity capture, the biotinylated proteins can be identified using mass spectrometry. BioID thus enables screening for physiologically relevant protein associations that occur over time in living cells. BioID is applicable to insoluble proteins such as lamins that are often refractory to study by other methods and can identify weak and/or transient interactions. We discuss the use of BioID to elucidate novel lamin-interacting proteins and its applications in a broad range of biological systems, and provide detailed protocols to guide new applications.

  1. Validity Evidence From Ratings of Pediatric Interns and Subinterns on a Subset of Pediatric Milestones.

    Science.gov (United States)

    Turner, Teri L; Bhavaraju, Vasudha L; Luciw-Dubas, Ulana A; Hicks, Patricia J; Multerer, Sara; Osta, Amanda; McDonnell, Jennifer; Poynter, Sue; Schumacher, Daniel J; Tenney-Soeiro, Rebecca; Waggoner-Fountain, Linda; Schwartz, Alan

    2017-06-01

    To investigate evidence for validity of faculty members' pediatric milestone (PM) ratings of interns (first-year residents) and subinterns (fourth-year medical students) on nine subcompetencies related to readiness to serve as a pediatric intern in the inpatient setting. The Association of Pediatric Program Directors Longitudinal Educational Assessment Research Network (APPD LEARN) and the National Board of Medical Examiners collaborated to investigate the utility of assessments of the PMs for trainees' performance. Data from 32 subinterns and 179 interns at 17 programs were collected from July 2012 through April 2013. Observers used several tools to assess learners. At each site, a faculty member used these data to make judgments about the learner's current developmental milestone in each subcompetency. Linear mixed models were fitted to milestone judgments to examine their relationship with learner's rank and subcompetency. On a 5-point developmental scale, mean milestone levels for interns ranged from 3.20 (for the subcompetency Work effectively as a member of a team) to 3.72 (Humanism) and for subinterns from 2.89 (Organize and prioritize care) to 3.61 (Professionalization). Mean milestone ratings were significantly higher for the Professionalism competency (3.59-3.72) for all trainees compared with Patient Care (2.89-3.24) and Personal and Professional Development (3.33-3.51). Mean intern ratings were significantly higher than mean subintern ratings for all nine subcompetencies except Professionalization, Humanism, and Trustworthiness. The PMs had a coherent internal structure and could distinguish between differing levels of trainees, which supports their validation for documenting developmental progression of pediatric trainees.

  2. Initial performance of a modified milestones global evaluation tool for semiannual evaluation of residents by faculty.

    Science.gov (United States)

    Borman, Karen R; Augustine, Rebecca; Leibrandt, Thomas; Pezzi, Christopher M; Kukora, John S

    2013-01-01

    To determine whether faculty could successfully evaluate residents using a competency-based modified Milestones global evaluation tool. A program's leadership team modified a draft Surgery Milestones Working Group summative global assessment instrument into a modified Milestones tool (MMT) for local use during faculty meetings devoted to semiannual resident review. Residents were scored on 15 items spanning all competencies using an 8-point graphic response scale; unstructured comments also were solicited. Arithmetic means were computed at the resident and postgraduate year cohort levels for items and competency item sets. Score ranges (highest minus lowest score) were calculated; variability was termed "low" (range 2.0). A subset of "low" was designated "small" (1.0-1.9). Trends were sought among item, competency, and total Milestones scores. MMT correlations with examination scores and multisource (360°) assessments were explored. The success of implementing MMT was judged using published criteria for educational assessment methods. Fully accredited, independently sponsored residency. Program leaders and 22 faculty members (71% voluntary, mean 12y of experience). Twenty-six residents were assessed, yielding 7 to 13 evaluations for MMT per categorical resident and 3 to 6 per preliminary trainee. Scores spanned the entire response scale. All MMT evaluations included narrative comments. Individual resident score variability was low (96% within competencies and 92% across competencies). Subset analysis showed that small variations were common (35% within competencies and 54% across competencies). Postgraduate year cohort variability was higher (61% moderate or high within competencies and 50% across competencies). Cohort scores at the item, competency, and total score levels exhibited rising trajectories, suggesting MMT construct validity. MMT scores did not demonstrate concurrent validity, correlating poorly with other metrics. The MMT met multiple criteria for

  3. Multimodal biometrics for identity documents (MBioID).

    Science.gov (United States)

    Dessimoz, Damien; Richiardi, Jonas; Champod, Christophe; Drygajlo, Andrzej

    2007-04-11

    The MBioID initiative has been set up to address the following germane question: What and how biometric technologies could be deployed in identity documents in the foreseeable future? This research effort proposes to look at current and future practices and systems of establishing and using biometric identity documents (IDs) and evaluate their effectiveness in large-scale developments. The first objective of the MBioID project is to present a review document establishing the current state-of-the-art related to the use of multimodal biometrics in an IDs application. This research report gives the main definitions, properties and the framework of use related to biometrics, an overview of the main standards developed in the biometric industry and standardisation organisations to ensure interoperability, as well as some of the legal framework and the issues associated to biometrics such as privacy and personal data protection. The state-of-the-art in terms of technological development is also summarised for a range of single biometric modalities (2D and 3D face, fingerprint, iris, on-line signature and speech), chosen according to ICAO recommendations and availabilities, and for various multimodal approaches. This paper gives a summary of the main elements of that report. The second objective of the MBioID project is to propose relevant acquisition and evaluation protocols for a large-scale deployment of biometric IDs. Combined with the protocols, a multimodal database will be acquired in a realistic way, in order to be as close as possible to a real biometric IDs deployment. In this paper, the issues and solutions related to the acquisition setup are briefly presented.

  4. Completion of Level 4 Milestone M4AT-15OR2301039 for the Johnson Noise Thermometry for Drift-free Temperature Measurements Work Package AT-15OR230103

    Energy Technology Data Exchange (ETDEWEB)

    Britton Jr, Charles L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-14

    This memorandum constitutes our September 2015 level 4 milestone for the project entitled “Johnson Noise Thermometry for Drift-free Temperature Measurements” and satisfies the Milestone/Activity (Conclude HFIR field demonstration of JNT prototype). The progress summary describes the work performed to complete the subject milestone.

  5. The relation between age of attainment of motor milestones and future cognitive and motor development in Bangladeshi children.

    Science.gov (United States)

    Hamadani, Jena Derakhshani; Tofail, Fahmida; Cole, Tim; Grantham-McGregor, Sally

    2013-01-01

    There is a need for easily administered, low-cost measures to assess child development in large field studies. Many researchers evaluate the age of attainment of motor milestones, but there is little information on their validity. A large longitudinal study (MINIMat) was conducted in a poor rural area of Bangladesh and we assessed the age of attainment of motor milestones in a subsample of over 2000 children. We examined their association with scores on the Bayley psychomotor development index (PDI) and mental development index (MDI) at 18 months and with scores on the Movement Assessment Battery for Children and with intelligence quotient (IQ) on the Wechsler Preschool and Primary Scale of Intelligence at 64 months. A field worker visited the children's homes monthly from 3 to 12 months of age and then at 15 months and examined the children. Mothers recorded the date of attainment of the milestones. Age of attainment of walking and standing alone was moderately correlated with the PDI and had significant but low associations with later motor development. They were as good as the PDI in predicting later motor development and could be used in field studies for that purpose. Milestone age of attainment had significant but low correlations with MDI and later IQ. Height for age at 15 months was related to milestones and later IQ and motor development and accounted for some of the association between milestones and IQ. Milestone age of attainment may not be sensitive enough to be used as an indicator of later IQ.

  6. The Self- and Other-Deception Questionnaires-Intellectual Disabilities (SDQ-ID and ODQ-ID): component analysis and reliability.

    Science.gov (United States)

    Jobson, Laura; Stanbury, Alexandra; Langdon, Peter E

    2013-10-01

    The objectives of this research were to: (1) investigate the component structure and psychometric properties of the Self- and Other-Deception Questionnaires-Intellectual Disabilities (SDQ-ID and ODQ-ID), (2) examine the relationship between social desirability and IQ, and (3) compare social desirability scores of those with intellectual disabilities (IDs) and a history of criminal offending to the social desirability scores of participants with IDs and those without IDs and no such history, controlling for general intellectual functioning. Men with mild to borderline IDs detained within medium secure inpatient forensic mental health services (N=40) completed the SDQ-ID and ODQ-ID at Time 1 and then two-weeks later at Time 2. Data for the men with and without IDs and no known criminal offending history were taken from a previous study (N=60). Following exploratory Principal Components Analysis, the number of questionnaire items were reduced, and a two-factor structure was found for the SDQ-ID which was labelled: (1) Positive Self Representation and (2) Denial of Intrusive Thoughts. A two-factor structure was also found for the ODQ-ID and these two factors were labelled: (1) Denial of Negative Social Interaction and (2) Untrustworthiness. Both the SDQ-ID and ODQ-ID had acceptable internal consistency and test-retest reliability. Fifteen percent of the variance in SDQ-ID scores was explained by Full Scale IQ, while 21% of the variance in ODQ-ID scores was explained by Full Scale IQ. Between group comparisons controlling for intelligence did not yield any significant differences. The shortened SDQ-ID and ODQ-ID have promising psychometric properties, and their component structures appear robust. Differences between men with and without IDs on these two measures of social desirability can be accounted for by differences in general intellectual functioning. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Novel ID-based anti-collision approach for RFID

    Science.gov (United States)

    Zhang, De-Gan; Li, Wen-Bin

    2016-09-01

    Novel correlation ID-based (CID) anti-collision approach for RFID under the banner of the Internet of Things (IOT) has been presented in this paper. The key insights are as follows: according to the deterministic algorithms which are based on the binary search tree, we propose a method to increase the association between tags so that tags can initiatively send their own ID under certain trigger conditions, at the same time, we present a multi-tree search method for querying. When the number of tags is small, by replacing the actual ID with the temporary ID, it can greatly reduce the number of times that the reader reads and writes to tag's ID. Active tags send data to the reader by the way of modulation binary pulses. When applying this method to the uncertain ALOHA algorithms, the reader can determine the locations of the empty slots according to the position of the binary pulse, so it can avoid the decrease in efficiency which is caused by reading empty slots when reading slots. Theory and experiment show that this method can greatly improve the recognition efficiency of the system when applied to either the search tree or the ALOHA anti-collision algorithms.

  8. Visualization on supercomputing platform level II ASC milestone (3537-1B) results from Sandia.

    Energy Technology Data Exchange (ETDEWEB)

    Geveci, Berk (Kitware, Inc., Clifton Park, NY); Fabian, Nathan; Marion, Patrick (Kitware, Inc., Clifton Park, NY); Moreland, Kenneth D.

    2010-09-01

    This report provides documentation for the completion of the Sandia portion of the ASC Level II Visualization on the platform milestone. This ASC Level II milestone is a joint milestone between Sandia National Laboratories and Los Alamos National Laboratories. This milestone contains functionality required for performing visualization directly on a supercomputing platform, which is necessary for peta-scale visualization. Sandia's contribution concerns in-situ visualization, running a visualization in tandem with a solver. Visualization and analysis of petascale data is limited by several factors which must be addressed as ACES delivers the Cielo platform. Two primary difficulties are: (1) Performance of interactive rendering, which is most computationally intensive portion of the visualization process. For terascale platforms, commodity clusters with graphics processors(GPUs) have been used for interactive rendering. For petascale platforms, visualization and rendering may be able to run efficiently on the supercomputer platform itself. (2) I/O bandwidth, which limits how much information can be written to disk. If we simply analyze the sparse information that is saved to disk we miss the opportunity to analyze the rich information produced every timestep by the simulation. For the first issue, we are pursuing in-situ analysis, in which simulations are coupled directly with analysis libraries at runtime. This milestone will evaluate the visualization and rendering performance of current and next generation supercomputers in contrast to GPU-based visualization clusters, and evaluate the performance of common analysis libraries coupled with the simulation that analyze and write data to disk during a running simulation. This milestone will explore, evaluate and advance the maturity level of these technologies and their applicability to problems of interest to the ASC program. Scientific simulation on parallel supercomputers is traditionally performed in four

  9. Systems biology markup language: Level 2 and beyond.

    Science.gov (United States)

    Finney, A; Hucka, M

    2003-12-01

    The SBML (systems biology markup language) is a standard exchange format for computational models of biochemical networks. We continue developing SBML collaboratively with the modelling community to meet their evolving needs. The recently introduced SBML Level 2 includes several enhancements to the original Level 1, and features under development for SBML Level 3 include model composition, multistate chemical species and diagrams.

  10. Siegel modular forms of genus 2 and level 2

    NARCIS (Netherlands)

    Cléry, F.; van der Geer, G.; Grushevsky, S.

    2015-01-01

    We study vector-valued Siegel modular forms of genus 2 on the three level 2 groups Γ[2] ◁ Γ1[2] ◁ Γ0[2] ⊂ Sp(4, ℤ). We give generating functions for the dimension of spaces of vector-valued modular forms, construct various vector-valued modular forms by using theta functions and describe the structu

  11. Level 2 Foundation Units. Key Stage 3: National Strategy.

    Science.gov (United States)

    Department for Education and Skills, London (England).

    These foundation units are aimed at pupils working within Level 2 entry to Year 7. They are designed to remind pupils what they know and take them forward. The units also will teach phonics knowledge from consonant-vowel-consonant (CVC) words to long vowel phonemes. The writing units focus on developing the following skills: understanding what a…

  12. Accident sequence precursor analysis level 2/3 model development

    Energy Technology Data Exchange (ETDEWEB)

    Lui, C.H. [Nuclear Regulatory Commission, Washington, DC (United States); Galyean, W.J.; Brownson, D.A. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1997-02-01

    The US Nuclear Regulatory Commission`s Accident Sequence Precursor (ASP) program currently uses simple Level 1 models to assess the conditional core damage probability for operational events occurring in commercial nuclear power plants (NPP). Since not all accident sequences leading to core damage will result in the same radiological consequences, it is necessary to develop simple Level 2/3 models that can be used to analyze the response of the NPP containment structure in the context of a core damage accident, estimate the magnitude of the resulting radioactive releases to the environment, and calculate the consequences associated with these releases. The simple Level 2/3 model development work was initiated in 1995, and several prototype models have been completed. Once developed, these simple Level 2/3 models are linked to the simple Level 1 models to provide risk perspectives for operational events. This paper describes the methods implemented for the development of these simple Level 2/3 ASP models, and the linkage process to the existing Level 1 models.

  13. Increasing Effectiveness of IDS to Improve Security in Intranet

    Directory of Open Access Journals (Sweden)

    Umesh K. Singh

    2005-01-01

    Full Text Available Today Intrusion Detection Systems (IDS are becoming one of the most important tools for intranet security. Research regarding Intrusion Detection Systems (IDSs has become more active with the recent increases in illegal accesses to computer systems. Many researchers focus only on the techniques or mechanisms for detecting intrusions automatically, without considering the security of IDSs themselves. When an intruder attacks and breaks into a system, he or she often deletes system logs and stops auditing processes. Thus, the security of an intrusion detection system is an important aspect of intrusion detection. This study explores the methods for increasing effectiveness in configurations of an IDS for obtaining maximum effects in security in an intranet. We also discuss the hurdles that have blocked successful measurements in this area and present suggestions for improving effectiveness of an IDS.

  14. A Dynamic ID-based Remote User Authentication Scheme

    CERN Document Server

    Das, Manik Lal; Gulati, Ved P

    2004-01-01

    Password-based authentication schemes are the most widely used techniques for remote user authentication. Many static ID-based remote user authentication schemes both with and without smart cards have been proposed. Most of the schemes do not allow the users to choose and change their passwords, and maintain a verifier table to verify the validity of the user login. In this paper we present a dynamic ID-based remote user authentication scheme using smart cards. Our scheme allows the users to choose and change their passwords freely, and do not maintain any verifier table. The scheme is secure against ID-theft, and can resist the reply attacks, forgery attacks, guessing attacks, insider attacks and stolen verifier attacks.

  15. Effect of ingredients on sensory profile of idli.

    Science.gov (United States)

    Durgadevi, Manoharan; Shetty, Prathapkumar H

    2014-09-01

    Idli is a traditional fermented food and is consumed in India and Srilanka. The objective of the present study is to select the ingredients for optimum desirable product characteristics and to identify the optimum ratios of ingredients and fermentation time with respect to sensory attributes using Response Surface Methodology (RSM). The sensory attributes included were color, appearance, texture, taste and overall quality. Preliminary trials were conducted using five variants of rice and common black gram dhal before framing a model using Central Composite Rotatable Design (CCRD). From the study it was found that a desirable score of 0.7439 was obtained for sensory attributes of idli made with the ratio of 3: 1.475 for IR20 idli rice and ADT3 variety black gram (with husk removed after soaking) fermented for 10.2 h. Principal Component Analysis (PCA) helped to discriminate the samples and attributes within the data matrix, depending upon their inter relationships.

  16. Test and calibration of the IDS fast-timing electronics

    CERN Document Server

    AUTHOR|(CDS)2160817

    2016-01-01

    The ISOLDE decay station(IDS) is one of the permanent experimental setups at the ISOLDE facility of CERN. IDS is used to study decay properties of radioactive nuclei. Thus, fast-timing electronics are necessary for extracting nuclear half-lives. The aims of this work are testing and optimization of the IDS fast-timing electronics as well as measuring a nuclear level half-life in the decay of $^{152}$Eu. The energy resolution of LaBr$_3$ $\\gamma$-detectors was characterized and optimized. A nuclear level lifetime of $^{152}$Eu was measured after obtaining the best parameters for energy resolution and time walk. Dedicated sorting scripts were developed in ROOT in order of perform the characterization and optimization automatically.

  17. The Danish eID Case: Twenty years of Delay

    DEFF Research Database (Denmark)

    Hoff, Jens Villiam; Hoff, Frederik Villiam

    2010-01-01

    The focus of this article is to explain why there is still no qualified digital signature in Denmark as defined by the EU eSignatures Directive nor any other nationwide eID even though Denmark had an early start in eGovernment, and a high level of "e-readiness" compared to other nations. Laying out...... of intergovernmental coordination and lack of cooperation between public and private sector. However, with the recent tender on digital signatures won by the PBS and the roll-out of the NemID it seems that Denmark will finally - after twenty years of delay - have an eID which can be widely used in the public as well...

  18. Generating Decision Trees Method Based on Improved ID3 Algorithm

    Institute of Scientific and Technical Information of China (English)

    Yang Ming; Guo Shuxu1; Wang Jun3

    2011-01-01

    The ID3 algorithm is a classical learning algorithm of decision tree in data mining.The algorithm trends to choosing the attribute with more values,affect the efficiency of classification and prediction for building a decision tree.This article proposes a new approach based on an improved ID3 algorithm.The new algorithm introduces the importance factor λ when calculating the information entropy.It can strengthen the label of important attributes of a tree and reduce the label of non-important attributes.The algorithm overcomes the flaw of the traditional ID3 algorithm which tends to choose the attributes with more values,and also improves the efficiency and flexibility in the process of generating decision trees.

  19. Memristor Crossbar-based Hardware Implementation of IDS Method

    CERN Document Server

    Merrikh-Bayat, Farnood; Rohani, Ali

    2010-01-01

    Ink Drop Spread (IDS) is the engine of Active Learning Method (ALM), which is the methodology of soft computing. IDS, as a pattern-based processing unit, extracts useful information from a system subjected to modeling. In spite of its excellent potential in solving problems such as classification and modeling compared to other soft computing tools, finding its simple and fast hardware implementation is still a challenge. This paper describes a new hardware implementation of IDS method based on the memristor crossbar structure. In addition of simplicity, being completely real-time, having low latency and the ability to continue working after the occurrence of power breakdown are some of the advantages of our proposed circuit.

  20. Milestones in software engineering and knowledge engineering history: a comparative review.

    Science.gov (United States)

    del Águila, Isabel M; Palma, José; Túnez, Samuel

    2014-01-01

    We present a review of the historical evolution of software engineering, intertwining it with the history of knowledge engineering because "those who cannot remember the past are condemned to repeat it." This retrospective represents a further step forward to understanding the current state of both types of engineerings; history has also positive experiences; some of them we would like to remember and to repeat. Two types of engineerings had parallel and divergent evolutions but following a similar pattern. We also define a set of milestones that represent a convergence or divergence of the software development methodologies. These milestones do not appear at the same time in software engineering and knowledge engineering, so lessons learned in one discipline can help in the evolution of the other one.

  1. Early motor developmental milestones and level of neuroticism in young adulthood

    DEFF Research Database (Denmark)

    Flensborg-Madsen, Trine; Sørensen, Holger Jelling; Revsbech, Rasmus

    2012-01-01

    intelligence. CONCLUSIONS: The findings are the first of their kind and suggest that delays in early motor development may not only characterize psychopathological disorders such as schizophrenia, but may also be associated with the personality dimension of neuroticism in adulthood.......BACKGROUND: Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors...... and personality traits is almost non-existent. This study is therefore the first to investigate associations between early motor developmental milestones and neuroticism in adulthood. Method Mothers of 9125 children of the Copenhagen Perinatal Cohort recorded 12 developmental milestones during the child's first...

  2. Timing of motor milestone achievement and development of overweight in childhood

    DEFF Research Database (Denmark)

    Morgen, Camilla Schmidt; Due, Pernille; Andersen, Anne-Marie Nybo;

    Background:  Late achievement of motor milestones may increase the risk of overweight since early achievers have an increased opportunity to build lean body mass and expend energy.  Overweight infants may have delayed achievement of gross motor milestones, as excess body fat limit mobility. Aim......: 1. To investigate whether delayed ability to sit and walk is associated with overweight at age 7 years 2. To examine whether age (in months) at achieving the ability to sit and walk is associated with a higher BMI at age 7. 3. To examine whether increasing weight at birth and at 5 months of age...... postpone the achievement of the ability to sit and walk independently. Methods: Data: The Danish National Birth Cohort. Study population consisted of 32,973 children who were followed from birth to age 7. Children were born between 1998 and 2003 and follow-up took place from 2003 to2010. Information...

  3. Milestones and entrustable professional activities: The key to practically translating competencies for interprofessional education?

    Science.gov (United States)

    Wagner, Susan J; Reeves, Scott

    2015-01-01

    Competency-based education and practice have become foundational for developing interprofessional education (IPE) and interprofessional collaboration. There has been a plethora of competencies developed in these areas recently, both at individual institutions and nationally; however, their effective integration and thus potential has not been fully realized educationally. Milestones and entrustable professional activities (EPAs) are new concepts and assessment approaches from medical education that provide a way to functionally use and maximize competencies to ensure that competency is attained. They are applicable to learning activities both within the classroom and the clinic, as well as to lifelong learning. This paper defines and describes milestones and EPAs, considers the importance of their application to IPE, and summarizes a future research project that will identify EPAs for an IPE curriculum.

  4. A Simple Quantum Integro-Differential Solver (SQuIDS)

    CERN Document Server

    Delgado, Carlos Alberto Arguelles; Weaver, Christopher N

    2014-01-01

    Simple Quantum Integro-Differential Solver (SQuIDS) is a C++ code designed to solve semi-analytically the evolution of a set of density matrices and scalar functions. This is done efficiently by expressing all operators in an SU(N) basis. SQuIDS provides a base class from which users can derive new classes to include new non-trivial terms from the right hand sides of density matrix equations. The code was designed in the context of solving neutrino oscillation problems, but can be applied to any problem that involves solving the quantum evolution of a collection of particles with Hilbert space of dimension up to six.

  5. ID-based Key-insulated Authenticated Key Agreement Protocol

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yuan; CHENG Xiao-ming; CHAI Zhen-chuan

    2007-01-01

    The basic idea behind an ID-based cryptosystem is that end user's public key can be determined by his identity information. Comparing with the traditional certificate-based cryptography, identity-based cryptography can eliminate much of the overhead associated with the deployment and management of certificate. However, exposure of private keys can be the most devastating attack on a public key based cryptosystem since such that all security guarantees are lost. In this paper, an ID-based authenticated key agreement protocol was presented. For solving the problem of key exposure of the basic scheme, the technique of key insulation was applied and a key insulated version is developed.

  6. Influence of height in neuropsychological functioning and acquisition of motor milestones in children

    Directory of Open Access Journals (Sweden)

    Tomás Caycho Rodríguez

    2014-05-01

    Full Text Available It aims to present a brief review on the effects of height above the sea level in neuropsychological functioning and the acquisition of motor milestones in children. While in Peru, there is no objective data to support such information, the reasoning described here is based on recent findings on the functional importance of the biophysical contexts that suggests the presence of slight alterations sensoperceptive functioning in high altitude conditions.

  7. Milestone-compatible neurology resident assessments: A role for observable practice activities.

    Science.gov (United States)

    Jones, Lyell K; Dimberg, Elliot L; Boes, Christopher J; Eggers, Scott D Z; Dodick, David W; Cutsforth-Gregory, Jeremy K; Leep Hunderfund, Andrea N; Capobianco, David J

    2015-06-02

    Beginning in 2014, US neurology residency programs were required to report each trainee's educational progression within 29 neurology Milestone competency domains. Trainee assessment systems will need to be adapted to inform these requirements. The primary aims of this study were to validate neurology resident assessment content using observable practice activities (OPAs) and to develop assessment formats easily translated to the Neurology Milestones. A modified Delphi technique was used to establish consensus perceptions of importance of 73 neurology OPAs among neurology educators and trainees at 3 neurology residency programs. A content validity score (CVS) was derived for each neurology OPA, with scores ≥4.0 determined in advance to indicate sufficient content validity. The mean CVS for all OPAs was 4.4 (range 3.5-5.0). Fifty-seven (78%) OPAs had a CVS ≥4.0, leaving 16 (22%) below the pre-established threshold for content validity. Trainees assigned a higher importance to individual OPAs (mean CVS 4.6) compared to faculty (mean 4.4, p = 0.016), but the effect size was small (η(2) = 0.10). There was no demonstrated effect of length of education experience on perceived importance of neurology OPAs (p = 0.23). Two sample resident assessment formats were developed, one using neurology OPAs alone and another using a combination of neurology OPAs and the Neurology Milestones. This study provides neurology training programs with content validity evidence for items to include in resident assessments, and sample assessment formats that directly translate to the Neurology Milestones. Length of education experience has little effect on perceptions of neurology OPA importance. © 2015 American Academy of Neurology.

  8. The Pediatrics Milestones Assessment Pilot: Development of Workplace-Based Assessment Content, Instruments, and Processes.

    Science.gov (United States)

    Hicks, Patricia J; Margolis, Melissa; Poynter, Sue E; Chaffinch, Christa; Tenney-Soeiro, Rebecca; Turner, Teri L; Waggoner-Fountain, Linda; Lockridge, Robin; Clyman, Stephen G; Schwartz, Alan

    2016-05-01

    To report on the development of content and user feedback regarding the assessment process and utility of the workplace-based assessment instruments of the Pediatrics Milestones Assessment Pilot (PMAP). One multisource feedback instrument and two structured clinical observation instruments were developed and refined by experts in pediatrics and assessment to provide evidence for nine competencies based on the Pediatrics Milestones (PMs) and chosen to inform residency program faculty decisions about learners' readiness to serve as pediatric interns in the inpatient setting. During the 2012-2013 PMAP study, 18 U.S. pediatric residency programs enrolled interns and subinterns. Faculty, residents, nurses, and other observers used the instruments to assess learner performance through direct observation during a one-month rotation. At the end of the rotation, data were aggregated for each learner, milestone levels were assigned using a milestone classification form, and feedback was provided to learners. Learners and site leads were surveyed and/or interviewed about their experience as participants. Across the sites, 2,338 instruments assessing 239 learners were completed by 630 unique observers. Regarding end-of-rotation feedback, 93% of learners (128/137) agreed the assessments and feedback "helped me understand how those with whom I work perceive my performance," and 85% (117/137) agreed they were "useful for constructing future goals or identifying a developmental path." Site leads identified several benefits and challenges to the assessment process. PM-based instruments used in workplace-based assessment provide a meaningful and acceptable approach to collecting evidence of learner competency development. Learners valued feedback provided by PM-based assessment.

  9. Preparing medical students for obstetrics and gynecology milestone level one: a description of a pilot curriculum

    Science.gov (United States)

    Morgan, Helen; Marzano, David; Lanham, Michael; Stein, Tamara; Curran, Diana; Hammoud, Maya

    2014-01-01

    Background The implementation of the Accreditation Council for Graduate Medical Education (ACGME) Milestones in the field of obstetrics and gynecology has arrived with Milestones Level One defined as the level expected of an incoming first-year resident. Purpose We designed, implemented, and evaluated a 4-week elective for fourth-year medical school students, which utilized a multimodal approach to teaching and assessing the Milestones Level One competencies. Methods The 78-hour curriculum utilized traditional didactic lectures, flipped classroom active learning sessions, a simulated paging curriculum, simulation training, embalmed cadaver anatomical dissections, and fresh-frozen cadaver operative procedures. We performed an assessment of student knowledge and surgical skills before and after completion of the course. Students also received feedback on their assessment and management of eight simulated paging scenarios. Students completed course content satisfaction surveys at the completion of each of the 4 weeks. Results Students demonstrated improvement in knowledge and surgical skills at the completion of the course. Paging confidence trended toward improvement at the completion of the course. Student satisfaction was high for all of the course content, and the active learning components of the curriculum (flipped classroom, simulation, and anatomy sessions) had higher scores than the traditional didactics in all six categories of our student satisfaction survey. Conclusions This pilot study demonstrates a practical approach for preparing fourth-year medical students for the expectations of Milestones Level One in obstetrics and gynecology. This curriculum can serve as a framework as medical schools and specific specialties work to meet the first steps of the ACGME's Next Accreditation System. PMID:25430640

  10. Preparing medical students for obstetrics and gynecology milestone level one: a description of a pilot curriculum

    Directory of Open Access Journals (Sweden)

    Helen Morgan

    2014-11-01

    Full Text Available Background: The implementation of the Accreditation Council for Graduate Medical Education (ACGME Milestones in the field of obstetrics and gynecology has arrived with Milestones Level One defined as the level expected of an incoming first-year resident. Purpose: We designed, implemented, and evaluated a 4-week elective for fourth-year medical school students, which utilized a multimodal approach to teaching and assessing the Milestones Level One competencies. Methods: The 78-hour curriculum utilized traditional didactic lectures, flipped classroom active learning sessions, a simulated paging curriculum, simulation training, embalmed cadaver anatomical dissections, and fresh-frozen cadaver operative procedures. We performed an assessment of student knowledge and surgical skills before and after completion of the course. Students also received feedback on their assessment and management of eight simulated paging scenarios. Students completed course content satisfaction surveys at the completion of each of the 4 weeks. Results: Students demonstrated improvement in knowledge and surgical skills at the completion of the course. Paging confidence trended toward improvement at the completion of the course. Student satisfaction was high for all of the course content, and the active learning components of the curriculum (flipped classroom, simulation, and anatomy sessions had higher scores than the traditional didactics in all six categories of our student satisfaction survey. Conclusions: This pilot study demonstrates a practical approach for preparing fourth-year medical students for the expectations of Milestones Level One in obstetrics and gynecology. This curriculum can serve as a framework as medical schools and specific specialties work to meet the first steps of the ACGME's Next Accreditation System.

  11. Toddlers’ Fine Motor Milestone Achievement Is Associated with Early Touchscreen Scrolling

    OpenAIRE

    2016-01-01

    Touchscreen technologies provide an intuitive and attractive source of sensory/cognitive stimulation for young children. Despite fears that usage may have a negative impact on toddlers’ cognitive development, empirical evidence is lacking. The current study presents results from the UK Toddler Attentional Behaviours and LEarning with Touchscreens (TABLET) project, examining the association between toddlers’ touchscreen use and the attainment of developmental milestones. Data were gathered in ...

  12. Putting the pediatrics milestones into practice: a consensus roadmap and resource analysis.

    Science.gov (United States)

    Schumacher, Daniel J; Spector, Nancy D; Calaman, Sharon; West, Daniel C; Cruz, Mario; Frohna, John G; Gonzalez Del Rey, Javier; Gustafson, Kristina K; Poynter, Sue Ellen; Rosenbluth, Glenn; Southgate, W Michael; Vinci, Robert J; Sectish, Theodore C

    2014-05-01

    The Accreditation Council for Graduate Medical Education has partnered with member boards of the American Board of Medical Specialties to initiate the next steps in advancing competency-based assessment in residency programs. This initiative, known as the Milestone Project, is a paradigm shift from traditional assessment efforts and requires all pediatrics residency programs to report individual resident progression along a series of 4 to 5 developmental levels of performance, or milestones, for individual competencies every 6 months beginning in June 2014. The effort required to successfully make this shift is tremendous given the number of training programs, training institutions, and trainees. However, it holds great promise for achieving training outcomes that align with patient needs; developing a valid, reliable, and meaningful way to track residents' development; and providing trainees with a roadmap for learning. Recognizing the resources needed to implement this new system, the authors, all residency program leaders, provide their consensus view of the components necessary for implementing and sustaining this effort, including resource estimates for completing this work. The authors have identified 4 domains: (1) Program Review and Development of Stakeholders and Participants, (2) Assessment Methods and Validation, (3) Data and Assessment System Development, and (4) Summative Assessment and Feedback. This work can serve as a starting point and framework for collaboration with program, department, and institutional leaders to identify and garner necessary resources and plan for local and national efforts that will ensure successful transition to milestones-based assessment. Copyright © 2014 by the American Academy of Pediatrics.

  13. [Evaluating language acquisition using the Early Language Milestone (ELM) and Munich developmental scales].

    Science.gov (United States)

    Páez-Pineda, Oscar D; Valencia-Valencia, Doris; Ortiz Calderón, Martha Vanessa

    2014-01-01

    Evaluating language development by comparing the Munich Development method to the Early Language Milestone scale for identifying both diagnostic tests' agreement and enriching neurodevelopmental consultation. The clinical histories of a cohort of 129 children were evaluated, as prematurity is a risk factor for deviation in children's language development. The children had less than 40 weeks gestational age and 0 to 12 months corrected age. They were given both tests between 2008 and 2011. The results from both scales were compared regarding receptive and expressive language and visual response (Early Language Milestone scale) and evaluation of verbal response, vocal play, understanding and expression (Munich scale). Student's T-test was used for comparing means for paired samples. Results: A statistically significant correlation (p<0.05) was found between both tests and between them and corrected age. It was seen that the higher the corrected age, the greater correlation there was between tests. The Early Language Milestone and Munich Development scales, regarding their components dealing with language, both represent useful tools for following-up premature children's language development.

  14. The Team Milestone Process: Integrated Team Activities to Track Team Development

    Directory of Open Access Journals (Sweden)

    Melissa J. Knott

    2012-04-01

    Full Text Available The well established use of teams in the classroom and in business has increased the need for teaching students tangible team skills. More than merely imparting knowledge about teams from an abstract perspective students need to graduate with effective team experiences. This paper presents a milestone process that helps students develop as a team and provides students with the opportunity to reflect on and learn from their experiences. As students familiarize themselves with different team processes and dynamics, this process allows students to hone their team skill with feedback from instructors who now have an additional tool to monitor and coach the students on an ongoing basis. For example, the milestone process allows the instructor to provide students with an early progress report on their semester projects while giving the instructor an opportunity for course content clarification and valuable early feedback that students can use for project revision. This paper describes the team milestone process along with instructions, grading, and possible modification and also presents feedback from instructors and students after use in an undergraduate organizational behavior course.

  15. L2 Milestone 5433: Characterization of Dynamic Behavior of AM and Conventionally Processed Stainless Steel (316L and 304L)

    Energy Technology Data Exchange (ETDEWEB)

    Gray, George Thompson [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Livescu, Veronica [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rigg, P. A. [Washington State Univ., Pullman, WA (United States). Inst. for Shock Physics; Trujillo, Carl Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cady, Carl McElhinney [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Chen, Shuh-Rong [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carpenter, John S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lienert, Thomas J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fensin, Saryu Jindal [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Knapp, Cameron M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Beal, Roberta Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Morrow, Benjamin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dippo, Olivia F. [Univ. of California, San Diego, CA (United States); Jones, David Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinez, Daniel Tito [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Valdez, James Anthony [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-26

    For additive manufacturing (AM) of metallic materials, the certification and qualification paradigm needs to evolve as there currently exists no broadly accepted “ASTM- or DIN-type” additive manufacturing certified process or AM-material produced specifications. Accordingly, design, manufacture, and thereafter implementation and insertion of AM materials to meet engineering applications requires detailed quantification of the constitutive (strength and damage) properties of these evolving materials, across the spectrum of metallic AM methods, in comparison/contrast to conventionally-manufactured metals and alloys. This report summarizes the 316L SS research results and presents initial results of the follow-on study of 304L SS. For the AM-316L SS investigation, cylindrical samples of 316L SS were produced using a LENS MR-7 laser additive manufacturing system from Optomec (Albuquerque, NM) equipped with a 1kW Yb-fiber laser. The microstructure of the AM-316L SS was characterized in both the “as-built” Additively Manufactured state and following a heat-treatment designed to obtain full recrystallization to facilitate comparison with annealed wrought 316L SS. The dynamic shock-loading-induced damage evolution and failure response of all three 316L SS materials was quantified using flyer-plate impact driven spallation experiments at peak stresses of 4.5 and 6.35 GPa. The results of these studies are reported in detail in the first section of the report. Publication of the 316L SS results in an archival journal is planned. Following on from the 316L SS completed work, initial results on a study of AM 304L SS are in progress and presented herein. Preliminary results on the structure/dynamic spallation property behavior of AM-304L SS fabricated using both the directed-energy LENS and an EOS powder-bed AM techniques in comparison to wrought 304L SS is detailed in this Level 2 Milestone report.

  16. Toddlers’ Fine Motor Milestone Achievement is Associated with Early Touchscreen Scrolling

    Directory of Open Access Journals (Sweden)

    Rachael Bedford

    2016-08-01

    Full Text Available Touchscreen technologies provide an intuitive and attractive source of sensory/cognitive stimulation for young children. Despite fears that usage may have a negative impact on toddlers’ cognitive development, empirical evidence is lacking. The current study presents results from the UK Toddler Attentional Behaviours and LEarning with Touchscreens (TABLET project, examining the association between toddlers’ touchscreen use and the attainment of developmental milestones. Data were gathered in an online survey of 715 parents of 6- to 36-month-olds to address two research questions: 1 How does touchscreen use change from 6 to 36 months? 2 In toddlers (19 to 36 months i.e., above the median age, n = 366, how does retrospectively reported age of first touchscreen usage relate to gross motor (i.e., walking, fine motor (i.e., stacking blocks and language (i.e., producing two-word utterances milestones? In our sample, the proportion of children using touchscreens, as well as the average daily usage time, increased with age (youngest quartile, 6-11 months: 51.22% users, 8.53 minutes per day; oldest quartile, 26-36 months: 92.05% users, average use of 43.95 minutes per day. In toddlers, aged 19-36 months, age of first touchscreen use was significantly associated with fine motor (stacking blocks, p = 0.03, after controlling for covariates age, sex, mother’s education (a proxy for SES as well as age of early fine motor milestone achievement (pincer grip. This effect was only present for active scrolling of the touchscreen p = 0.04, not for video watching. No significant relationships were found between touchscreen use and either gross motor or language milestones. Touchscreen use increases rapidly over the first three years of life. In the current study, we find no evidence to support a negative association between the age of first touchscreen usage and developmental milestones. Indeed, earlier touchscreen use, specifically scrolling of the screen, was

  17. Imagery Measures of Ego, Id, Superego, and Identity: Validity Studies.

    Science.gov (United States)

    Cartwright, D.; DeBruin, J.

    1988-01-01

    Five validity studies of the id, ego, superego, and identity scales of the Study of Imagery are reported, using undergraduate students. Multistage Bonferroni procedures are used to evaluate the significance of results. The scales are related to each other and to toughmindedness, self-control, and behavioral conflict. (TJH)

  18. 59 FR- Realty Action; Ada and Owyhee, ID

    Science.gov (United States)

    1994-05-03

    ...-332A-02; IDI-29516] Realty Action; Ada and Owyhee, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action--IDI-29516; Exchange of public and private lands in Ada and Owyhee.... Containing 640 acres, more or less, in Owyhee County. The purpose of this exchange is to dispose of...

  19. Chronic arsenic intoxication diagnostic score (CAsIDS).

    Science.gov (United States)

    Dani, Sergio Ulhoa; Walter, Gerhard Franz

    2017-08-31

    Arsenic and its compounds are well-established, potent, environmentally widespread and persistent toxicants with metabolic, genotoxic, mutagenic, teratogenic, epigenetic and carcinogenic effects. Arsenic occurs naturally in the Earth's crust, but anthropogenic arsenic emissions have surmounted the emissions from important natural sources such as volcanism. Inorganic arsenicals exhibit acute and chronic toxicities in virtually all cell types and tissues, and hence arsenic intoxication affects multiple systems. Whereas acute arsenic intoxication is rare and relatively easy to diagnose, chronic arsenic intoxication (CAsI) is common but goes often misdiagnosed. Based on a review of the literature as well as our own clinical experience, we propose a chronic arsenic intoxication diagnostic score (CAsIDS). A distinctive feature of CAsIDS is the use of bone arsenic load as an essential criterion for the individual risk assessment of chronic arsenic intoxication, combined with a systemic clinical assessment. We present clinical examples where CAsIDS is applied for the diagnosis of CAsI, review the main topics of the toxicity of arsenic in different cell and organ systems and discuss the therapy and prevention of disease caused or aggravated by chronic arsenic intoxication. CAsIDS can help physicians establish the diagnosis of CAsI and associated conditions. Copyright © 2017 John Wiley & Sons, Ltd.

  20. 76 FR 33651 - Approval and Promulgation of Implementation Plans; ID

    Science.gov (United States)

    2011-06-09

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Implementation Plans; ID AGENCY: Environmental... Implementation Plan (SIP) that were submitted to EPA by the State of Idaho on April 16, 2007. This SIP submittal... through 668. Sec. 52.670 Identification of plan. * * * * * (c) * * * EPA-Approved Idaho Regulations State...

  1. Evolution of the ID Process at Sprint: A Practitioner's Perspective.

    Science.gov (United States)

    Beard, Michael W.

    1999-01-01

    Provides instructional developers' (ID) insights and observations based on the experiences of a training and development organization, Sprint's University of Excellence (UE), as it evolved from a small group of 20-25 individuals in 1990 to a large business unit comprising almost 400 individuals in 1999. Discussion includes course development…

  2. Student ID Cards: What You Should Know About Them

    Science.gov (United States)

    Hoffman, Jonathan; McGuire, Agnes C.

    1973-01-01

    Discusses the usefulness of photo ID cards for school security purposes, library control, student activities, and bus transportation control. Examines ways in which card costs can be reduced and the pros and cons of producing the cards at the school or of letting the work out. Problems involving card abuse and student rights are also considered.…

  3. LED-ID System: Coverage And Fast Link Recovery Technique

    Directory of Open Access Journals (Sweden)

    Muhammad Shahin Uddin

    2012-11-01

    Full Text Available Recently Light Emitting Diodes (LEDs are considered to represent the next generation of lighting and communication technology. LED-ID (Light Emitting Diode – Identification is one of the key technologies for identification, data transmission and illumination simultaneously. This is the new paradigm in theidentification technology environment. LED-ID system typically needs line of sight (LOS to support narrow FOV transceivers links to achieve high data rate but reduced the coverage, increase the disconnection rate of the link. Also when the receiver moves horizontally or vertically, in that case coverage also varied and LOS relies upon direct link between transmitter and receiver. Link recovery is a new challenge for reliable LED-ID system. Fast link recovery techniques are essential for the making the system robust. In this paper we discuss about the horizontal and vertical coverage variation in terms of received power and fast link recovery technique for the LED-ID system considering both LOS and NLOS reflection.

  4. Milestone – a selective herbicide for the control of important grasses and broadleaved weeds in winter oilseed rape

    Directory of Open Access Journals (Sweden)

    Zotz, Agnes

    2016-02-01

    Full Text Available MilestoneTM herbicide contains the active substance propyzamide (500 g/L and aminopyralid (5.3 g a.e./L and is formulated as a suspension concentrate (SC. Registration for Milestone for the use in winter oilseed rape was granted in Germany in July 2014. The active substance propyzamide is well known from the product KerbTM FLO (containing 500 g/L propyzamide, suspension concentrate, SC which is widely used in winter oilseed rape (WITTROCK et al., 2008. Aminopyralid is formulated in the commercial product Runway (clopyralid + picloram + aminopyralid. Milestone is applied with a use rate of 1.5 L/ha as a post-emergence herbicide from growth stage BBCH 14 of the crop at the beginning of November until February. Kerb FLO is applied with a use rate of 1.875 L/ha at the same timing. The efficacy of Milestone and Kerb FLO was tested in randomised and replicated plot trials in Germany, France and the United Kingdom. Milestone and Kerb FLO showed comparable and very high control levels against monocotyledonous species such as Alopecurus myosuroides, Apera spica-venti, Bromus species and volunteer cereals. Milestone shows a broader spectrum of activity vs. Kerb FLO against dicotyledonous weeds such as Matricaria chamomilla, Papaver rhoeas and Centaurea cyanus. The use of Milestone in dense crops (as the situation was in autumn 2014 for many areas in Germany shows very high efficacy levels as well. The comparison of various application timings between end of October until beginning of December confirms the application date early November for best results. Milestone controls herbicide-resistant weed populations and can be considered an important part of a resistance management program not only in winter oilseed rape but as a component of an integrated weed management strategy in cropping systems.

  5. Sequence ID and annotation information - Gclust Server | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us Gclust Server Sequence ID and annotation information Data detail Data name Sequence ID and ann...e specifying the ID, length and annotation information of the amino acid sequences of the predicted proteins...f amino acid sequence (Sequence ID) Field 2 Length of amino acid sequence Field 3 Ann...of This Database Site Policy | Contact Us Sequence ID and annotation information - Gclust Server | LSDB Archive ...

  6. Greater length-for-age increases the odds of attaining motor milestones in Vietnamese children aged 5-18 months.

    Science.gov (United States)

    Kulkarni, Shibani; Ramakrishnan, Usha; Dearden, Kirk A; Marsh, David R; Ha, Tran Thu; Tran, Thach Duc; Pachón, Helena

    2012-01-01

    Early childhood malnutrition has been associated with delayed development. Limited data exist however about the timing of developmental delay early in life. We assessed motor milestone (MM) achievement using the World Health Organization's windows of achievement for gross motor milestones. We performed secondary analysis of baseline data of 158 Vietnamese children aged 5-18 months from a randomized community intervention trial. Median age of motor milestone achievement was compared to WHO reported medians. Multivariate logistic regression was used to identify socioeconomic, anthropometric and dietary factors associated with motor milestone achievement during the windows of achievement. Thirty four per cent of the children were stunted. Median age of MM achievement of Vietnamese children lagged by 2.4-3.7 months, compared to the WHO median for all MMs. Greater length-for-age increased the odds for walking with assistance, standing alone and walking alone by more than 3 times. Greater weight-for-age increased the odds by 3.6 for hand-and-knees crawling. Likewise, frequency of daily complementary feeding raised the odds by 3.6 for standing with assistance. In this first application of WHO windows of achievement in Viet Nam, pre-schoolers achieved motor milestones later than WHO reported median age. High prevalence of stunting and association of length-for-age with motor milestone achievement underscore the importance of addressing chronic malnutrition to optimize children's growth and development.

  7. Subgroups associated with lower physical fitness in older adults with ID : Results of the HA-ID study

    NARCIS (Netherlands)

    Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2014-01-01

    Although physical fitness is generally very low in older adults with intellectual disabilities (ID), levels may differ across subgroups. It is important to identify which subgroups need to be targeted specifically in physical activity and fitness interventions and reference values. Physical fitness

  8. Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2

    NARCIS (Netherlands)

    Buitenhuis, M; van Deutekom, HWM; Verhagen, LP; Castor, A; Jacobsen, SEW; Lammers, JWJ; Koenderman, L; Coffer, PJ

    2005-01-01

    Inhibitor of DNA binding (Id) proteins function as inhibitors of members of the basic helix-loop-helix family of transcription factors and have been demonstrated to play an important role in regulating lymphopoiesis. However, the role of these proteins in regulation of myelopoiesis is currently

  9. Preemie Milestones

    Science.gov (United States)

    ... head to follow familiar voices Laughs and squeals Combines sounds more often (for example, “aaah-oooh”, “gaaa- ... a time Puts small objects in container Language Combines movements with sounds (reaches for an object and ...

  10. Historic Milestone

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    As a well-known Confucius saying reads, "At 30 years old, Iplanted my feet firm upon the ground." It means a 30-year-old is ex-pected to be mature and established. That is also true for the relationsbetween China and the United States.

  11. Exploiting Aura OMI Level 2 Data with High Resolution Visualization

    Science.gov (United States)

    Wei, J. C.; Yang, W.; Johnson, J. E.; Zhao, P.; Gerasimov, I. V.; Pham, L.; Vicente, G. A.; Shen, S.

    2014-12-01

    Satellite data products are important for a wide variety of applications that can bring far-reaching benefits to the science community and the broader society. These benefits can best be achieved if the satellite data are well utilized and interpreted, such as model inputs from satellite, or extreme event (such as volcano eruption, dust storm, …etc) interpretation from satellite. Unfortunately, this is not always the case, despite the abundance and relative maturity of numerous satellite data products provided by NASA and other organizations. One way to help users better understand the satellite data is to provide data along with 'Images', including accurate pixel-level (Level 2) information, pixel coverage area delineation, and science team recommended quality screening for individual geophysical parameters. Goddard Earth Sciences Data and Information Services Center (GES DISC) always strives to best support (i.e., Software-as-a-service, SaaS) the user-community for NASA Earth Science Data. In this case, we will present a new visualization tool that helps users exploiting Aura Ozone Monitoring Instrument (OMI) Level 2 data. This new visualization service utilizes Open Geospatial Consortium (OGC) standard-compliant Web Mapping Service (WMS) and Web Coverage Service (WCS) calls in the backend infrastructure. The functionality of the service allows users to select data sources (e.g., multiple parameters under the same measurement, like NO2 and SO2 from OMI Level 2 or same parameter with different methods of aggregation, like NO2 in OMNO2G and OMNO2D products), defining area-of-interest and temporal extents, zooming, panning, overlaying, sliding, and data subsetting and reformatting. The interface will also be able to connect to other OGC WMS and WCS servers, which will greatly enhance its expandability to integrate additional outside data/map sources (such as Global Imagery Browse Services (GIBS)).

  12. Review of APR+ Level 2 PSA. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Lehner, John R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Mubayi, Vinod [Brookhaven National Lab. (BNL), Upton, NY (United States); Pratt, W. Trevor [Brookhaven National Lab. (BNL), Upton, NY (United States); Kim, Do Sam [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of); Cho, Yong Jin [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of); Cho, Sang Jin [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of); Kim, In Goo [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of)

    2012-02-17

    Brookhaven National Laboratory (BNL) assisted the Korea Institute of Nuclear Safety (KINS) in reviewing the Level 2 Probabilistic Safety Assessment (PSA) of the APR+ Advanced Pressurized Water Reactor (PWR) prepared by the Korea Hydro & Nuclear Power Co., Ltd (KHNP) and KEPCO Engineering & Construction Co., Inc. (KEPCO-E&C). The work described in this report involves a review of the APR+ Level 2 PSA submittal [Ref. 1]. The PSA and, therefore, the review is limited to consideration of accidents initiated by internal events. As part of the review process, the review team also developed three sets of Requests for Additional Information (RAIs). These RAIs were provided to KHNP and KEPCO-E&C for their evaluation and response. This final detailed report documents the review findings for each technical element of the PSA and includes consideration of all of the RAIs made by the reviewers as well as the associated responses. This final report was preceded by an interim report [Ref. 2] that focused on identifying important issues regarding the PSA. In addition, a final meeting on the project was held at BNL on November 21-22, 2011, where BNL and KINS reviewers discussed their preliminary review findings with KHNP and KEPCO-E&C staffs. Additional information obtained during this final meeting was also used to inform the review findings of this final report. The review focused not only on the robustness of the APR+ design to withstand severe accidents, but also on the capability and acceptability of the Level 2 PSA in terms of level of detail and completeness. The Korean nuclear regulatory authorities will decide whether the PSA is acceptable and the BNL review team is providing its comments for KINS consideration. Section 2.0 provides the basis for the BNL review. Section 3.0 presents the review of each technical element of the PSA. Conclusions and a summary are presented in Section 4.0. Section 5.0 contains the references.

  13. The Visualization of CERES Level 2 Footprint Data on Web

    Science.gov (United States)

    Chu, C.; Mitrescu, C.; Doelling, D.

    2012-12-01

    The Clouds and Earth's Radiant Energy System (CERES) project provides over 11-years of climate quality observed TOA and computed surface fluxes with associated cloud retrievals. In order to facilitate a fast, efficient, user-friendly access of this unique dataset to the remote sensing, climate modeling, and surface flux science communities, a new computer architecture was implemented. The CERES Ordering Tool (http://ceres.larc.nasa.gov/order_data.php) has successfully provided user interfaces to browse hundreds of images instantly and/or to order subsetted CERES Level 3 and 4 data tailored to their specific research application. Expanding the ordering tool to incorporate CERES level-2 footprint data had several challenges. First, the volume data is 100 times greater than the level-3 and 4 datasets. This amount of data required the web servers to access the data from the archive itself, whereas the level-3 products could be tailored for quick access. Secondly, the browse interface needed significant restructuring to convert from gridded to point source data and allowing the visualization of images containing an order of a million pixels. This poster presents the level-2 system architecture, with emphasis on efficient data access and the user browse interface. The interface allows users to investigate multiple parameters at the footprint level with instant feed of lat/lon/value and with the assistance of the Google Earth to indicate the location of footprints.

  14. ID-Based Fair Off-Line Electronic Cash System with Multiple Banks

    Institute of Scientific and Technical Information of China (English)

    Chang-Ji Wang; Yong Tang; Qing Li

    2007-01-01

    ID-based public key cryptography (ID-PKC) has many advantages over certificate-based public key cryptog-raphy (CA-PKC), and has drawn researchers’ extensive attention in recent years. However, the existing electronic cash schemes are constructed under CA-PKC, and there seems no electronic cash scheme under ID-PKC up to now to the best of our knowledge. It is important to study how to construct electronic cash schemes based on ID-PKC from views on both practical perspective and pure research issue. In this paper, we present a simpler and provably secure ID-based restrictive partially blind signature (RPBS), and then propose an ID-based fair off-line electronic cash (ID-FOLC) scheme with multiple banks based on the proposed ID-based RPBS. The proposed ID-FOLC scheme with multiple banks is more efficient than existing electronic cash schemes with multiple banks based on group blind signature.

  15. 1.2.1.1 Harvest, Collection and Storage Quarter 3 Milestone Report

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, Lynn M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, William A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cafferty, Kara G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bonner, Ian J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Huang, Qiyang [Idaho National Lab. (INL), Idaho Falls, ID (United States); Colby, Rachel D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-07-01

    Single pass baling of corn stover is required in order to meet targets for the herbaceous biomass 2017 logistics design case. Single-pass pass stover harvest is based on the grain harvest and generally results in stover with a moisture content of 30-50% wet basis (w.b). Aerobic storage of corn stover with high moisture results in high levels of dry matter loss (DML), up to 25%. Anaerobic storage (ensiling) reduces DML to less than 5%, but additional costs are associated with handling and transporting the extra moisture in the biomass. This milestone provides a best-estimate of costs for using high moisture feedstock within the conventional baled logistics system. The costs of three (3) anaerobic storage systems that reduce dry matter losses (bale wrap, silage tube, and silage drive over pile) are detailed in this milestone and compared to both a conventional dry-baled corn stover case and a high moisture bale case, both stored aerobically. The total logistics cost (harvest, collection, storage, and transportation) of the scenarios are as follows: the conventional multi-pass dry bale case and the single-pass high moisture case stored aerobically were nearly equivalent at $61.15 and $61.24/DMT. The single-pass bale wrap case was the lowest at $57.63/DMT. The bulk anaerobic cases were the most expensive at $84.33 for the silage tube case and $75.97 for the drive over pile, which reflect the additional expense of transporting high-moisture bulk material; however, a reduction in preprocessing costs may occur because these feedstocks are size reduced in the field. In summary, the costs estimates presented in this milestone report can be used to determine if anaerobic storage of high-moisture corn stover is an economical option for dry matter preservation.

  16. Integrating the NAS Milestones and handheld technology to improve residency training and assessment.

    Science.gov (United States)

    Cooney, Carisa M; Redett, Richard J; Dorafshar, Amir H; Zarrabi, Bahar; Lifchez, Scott D

    2014-01-01

    To incorporate the use of an intuitive and robust assessment tool in conjunction with the Next Accreditation System Milestones to maximize opportunities for trainee performance feedback and continuous trainee assessment, with the long-term goal of increasing the rate of performance improvement and mastery of knowledge and surgical skills. Pilot study. Johns Hopkins Medicine, Baltimore, MD. Primary, tertiary, and quaternary clinical care; institutional environment. Experimental group: two randomly selected postgraduate year-1 integrated training program residents per year for 2 consecutive years from the Department of Plastic and Reconstructive Surgery. traditionally trained residents from the integrated training program in the Department of Plastic and Reconstructive Surgery. Study duration: 7 years (until residents complete residency training). This assessment strategy would create large amounts of informative data on trainees, which can be cross-referenced to determine trainee progress. Assessment data would be collected continuously from all faculty surgeons. Comparisons of faculty and resident self-assessments would facilitate resident evaluations. Ease of use of the data collection structure would improve faculty evaluation compliance and timely resident case report completion. Improving the efficiency and efficacy of competency documentation is critical. Using portable technologies is an intuitive way to improve the trainee assessment process. We anticipate that this 2-pronged approach to trainee assessments would quickly provide large amounts of informative data to better assess trainee progress and inform Milestone assessments in a manner that facilitates immediate feedback. Assessments of faculty and resident satisfaction would help us further refine the assessment process as needed. If successful, this format could easily be implemented by other training programs. Innovations in Surgical Education: Milestones. © 2013 Published by Association of Program

  17. Piloting a Structured Practice Audit to Assess ACGME Milestones in Written Handoff Communication in Internal Medicine.

    Science.gov (United States)

    Martin, Shannon K; Farnan, Jeanne M; McConville, John F; Arora, Vineet M

    2015-06-01

    Written communication skills are integral to patient care handoffs. Residency programs require feasible assessment tools that provide timely formative and summative feedback, ideally linked to the Accreditation Council for Graduate Medical Education Milestones. We describe the use of 1 such tool-UPDATED-to assess written handoff communication skills in internal medicine interns. During 2012-2013, the authors piloted a structured practice audit at 1 academic institution to audit written sign-outs completed by 45 interns, using the UPDATED tool, which scores 7 aspects of sign-out communication linked to milestones. Intern sign-outs were audited by trained faculty members throughout the year. Results were incorporated into intern performance reviews and Clinical Competency Committees. A total of 136 sign-outs were audited (averaging 3.1 audits per intern). In the first trimester, 14 interns (31%) had satisfactory audit results. Five interns (11%) had critical deficiencies and received immediate feedback, and the remaining 26 (58%) were assigned future audits due to missing audits or unsatisfactory scores. In the second trimester, 21 interns (68%) had satisfactory results, 1 had critical deficiencies, and 9 (29%) required future audits. Nine of the 10 remaining interns in the final trimester had satisfactory audits. Faculty time was estimated at 10 to 15 minutes per sign-out audited. The UPDATED audit is a milestone-based tool that can be used to assess written sign-out communication skills in internal medicine residency programs. Future work is planned to adapt the tool for use by senior supervisory residents to appraise sign-outs in real time.

  18. Entitlement Management: Ready to Enter the IdM Mainstream

    Science.gov (United States)

    Gebel, Gerry; Wang, Alice

    Externalizing authorization processing from business applications has been a goal for architects and developers for many years. Recent compliance demands for more granular access control and policy transparency have increased the urgency to adopt an architectural model where authorization and entitlement management are consumed as a service rather than embedded within business applications. Major software vendors, such as Microsoft, Oracle, and SAP, are making significant steps to separate IdM functionality, including entitlement management from application logic. The market has also responded with a plethora of products that provide entitlement management and authorization functionality for commercial or custom-built application environments. Finally, the Extensible Access Control Markup Language (XACML) has emerged as the consensus authorization standard being supported by a growing number of IT and application vendors. Collectively, these forces form the basis of a nascent IdM market segment referred to as entitlement management.

  19. La I+D en las pymes: Intensidad y estrategia

    Directory of Open Access Journals (Sweden)

    Anna Arbussà

    2004-01-01

    Full Text Available ¿Es importante la innovación en las pequeñas y medianas empresas? ¿De qué dependen sus estrategias de inversión en I+D? En este artículo respondemos a estas preguntas basándonos en nuevos datos obtenidos sobre una muestra de pymes catalanas. Explicamos cómo varía la intensidad de la I+D según sean la demanda, la oportunidad tecnológica y las condiciones de apropiabilidad en el sector industrial donde se halle la empresa; y presentamos las estrategias de desarrollo interno y adquisición externa de tecnología seguidas por las empresas más competitivas.

  20. De l'idée au businessplan

    OpenAIRE

    Frey, Urs

    2012-01-01

    La création est l'une des nombreuses voies pour arriver à sa propre entreprise. Si vous choisissez cette voie, il est déterminant, pour le succès ultérieur de votre jeune entreprise, que la planification et la mise en oeuvre soient optimales. Le businessplan a pour but de détailler pas à pas l'idée d'entreprise, d'opposer les opportunités aux risques et d'élaborer des budgets. Nous vous indiquons les obstacles que vous pouvez rencontrer sur ce chemin, de l'idée à la création d'une entreprise ...

  1. A NEW EFFICIENT ID-BASED PROXY BLIND SIGNATURE SCHEME

    Institute of Scientific and Technical Information of China (English)

    Ming Yang; Wang Yumin

    2008-01-01

    In a proxy blind signature scheme, the proxy signer is allowed to generate a blind signature on behalf of the original signer. The proxy blind signature scheme is useful in several applications such as e-voting, e-payment, etc. Recently, Zheng, et al. presented an IDentity (ID)-based proxy blind signature. In this paper, a new efficient ID-based proxy blind signature scheme from bilinear pairings is proposed, which can satisfy the security properties of both the proxy signatures and the blind signature schemes. Analysis of the scheme efficiency shows that the new scheme is more efficient than Zheng, et al.'s scheme. The proposed scheme is more practical in the real world.

  2. Tailoring a corporate compliance program for an IDS.

    Science.gov (United States)

    Berkey, M F

    1999-01-01

    Integrated delivery systems (IDSs) face a particular challenge in implementing a corporate compliance program--that of ensuring the program addresses issues of compliance with payment rules and regulations consistently across every component of the health system. To successfully implement an effective compliance program, the various components of the IDS first must understand what such a program is intended to accomplish, and any internal resistance to developing the program must be overcome. The IDS then can undertake identifying and assessing areas of the health system at risk of being in noncompliance, designing and implementing the program, auditing claims processing and cost reporting throughout the health system to ensure systemwide compliance, and maintaining the program through ongoing monitoring and training.

  3. ID-kaart on mugav ja praktiline dokument / Heiki Raudla

    Index Scriptorium Estoniae

    Raudla, Heiki, 1949-

    2001-01-01

    Ilmunud ka: Severnoje Poberezhje 12. okt., lk. 2; Lääne Elu 13. okt., lk. 2; Hiiumaa 13. okt., lk. 2; Koit 16. okt., lk. 6; Nädaline 16. okt., lk. 4; Sakala 18. okt., lk. 2; Valgamaalane 18. okt., lk. 2; Pjarnuskii Ekspress 12. okt., lk. 2; Meie Maa 19. okt., lk. 2; Hiiu Leht 23. okt., lk. 2; Järva Teataja 30. okt., lk. 2. Siseministri nõunik Heiki Raudla ID-kaardist

  4. Guinea pig ID-like families of SINEs.

    Science.gov (United States)

    Kass, David H; Schaetz, Brian A; Beitler, Lindsey; Bonney, Kevin M; Jamison, Nicole; Wiesner, Cathy

    2009-05-01

    Previous studies have indicated a paucity of SINEs within the genomes of the guinea pig and nutria, representatives of the Hystricognathi suborder of rodents. More recent work has shown that the guinea pig genome contains a large number of B1 elements, expanding to various levels among different rodents. In this work we utilized A-B PCR and screened GenBank with sequences from isolated clones to identify potentially uncharacterized SINEs within the guinea pig genome, and identified numerous sequences with a high degree of similarity (>92%) specific to the guinea pig. The presence of A-tails and flanking direct repeats associated with these sequences supported the identification of a full-length SINE, with a consensus sequence notably distinct from other rodent SINEs. Although most similar to the ID SINE, it clearly was not derived from the known ID master gene (BC1), hence we refer to this element as guinea pig ID-like (GPIDL). Using the consensus to screen the guinea pig genomic database (Assembly CavPor2) with Ensembl BlastView, we estimated at least 100,000 copies, which contrasts markedly to just over 100 copies of ID elements. Additionally we provided evidence of recent integrations of GPIDL as two of seven analyzed conserved GPIDL-containing loci demonstrated presence/absence variants in Cavia porcellus and C. aperea. Using intra-IDL PCR and sequence analyses we also provide evidence that GPIDL is derived from a hystricognath-specific SINE family. These results demonstrate that this SINE family continues to contribute to the dynamics of genomes of hystricognath rodents.

  5. FastID: Extremely Fast Forensic DNA Comparisons

    Science.gov (United States)

    2017-05-19

    FastID: Extremely Fast Forensic DNA Comparisons Darrell O. Ricke, PhD Bioengineering Systems & Technologies Massachusetts Institute of...Technology Lincoln Laboratory Lexington, MA USA Darrell.Ricke@ll.mit.edu Abstract—Rapid analysis of DNA forensic samples can have a critical impact on...time sensitive investigations. Analysis of forensic DNA samples by massively parallel sequencing is creating the next gold standard for DNA

  6. ID-kaart on mugav ja praktiline dokument / Heiki Raudla

    Index Scriptorium Estoniae

    Raudla, Heiki, 1949-

    2001-01-01

    Ilmunud ka: Severnoje Poberezhje 12. okt., lk. 2; Lääne Elu 13. okt., lk. 2; Hiiumaa 13. okt., lk. 2; Koit 16. okt., lk. 6; Nädaline 16. okt., lk. 4; Sakala 18. okt., lk. 2; Valgamaalane 18. okt., lk. 2; Pjarnuskii Ekspress 12. okt., lk. 2; Meie Maa 19. okt., lk. 2; Hiiu Leht 23. okt., lk. 2; Järva Teataja 30. okt., lk. 2. Siseministri nõunik Heiki Raudla ID-kaardist

  7. El sistema español de I+D

    Directory of Open Access Journals (Sweden)

    López Facal, Javier

    1997-06-01

    Full Text Available Not available.Para centrar el lugar que ocupan las Bibliotecas y Centros de documentación en el Sistema de I+D, se resume la evolución de la política científica española desde los años cincuenta y se describe la estructura actual de este sistema, sus magnitudes principales y sus deficiencias.

  8. 新一代里程碑 摩托罗拉Milestone2

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    摩托罗拉的Droid2发布后,众多机友对它的GSM/WCDMA版本也十分期待,之前曾有流言称GSM/WCDMA版本的Droid2将不采用Milestone(里程碑)的商品名.而改称Droid Pro,不过这一流言随着摩托官方正式发布Milestone2后不攻自破。

  9. Applying Fuzzy ID3 Decision Tree for Software Effort Estimation

    CERN Document Server

    Elyassami, Sanaa

    2011-01-01

    Web Effort Estimation is a process of predicting the efforts and cost in terms of money, schedule and staff for any software project system. Many estimation models have been proposed over the last three decades and it is believed that it is a must for the purpose of: Budgeting, risk analysis, project planning and control, and project improvement investment analysis. In this paper, we investigate the use of Fuzzy ID3 decision tree for software cost estimation; it is designed by integrating the principles of ID3 decision tree and the fuzzy set-theoretic concepts, enabling the model to handle uncertain and imprecise data when describing the software projects, which can improve greatly the accuracy of obtained estimates. MMRE and Pred are used as measures of prediction accuracy for this study. A series of experiments is reported using two different software projects datasets namely, Tukutuku and COCOMO'81 datasets. The results are compared with those produced by the crisp version of the ID3 decision tree.

  10. Applying Fuzzy ID3 Decision Tree for Software Effort Estimation

    Directory of Open Access Journals (Sweden)

    Ali Idri

    2011-07-01

    Full Text Available Web Effort Estimation is a process of predicting the efforts and cost in terms of money, schedule and staff for any software project system. Many estimation models have been proposed over the last three decades and it is believed that it is a must for the purpose of: Budgeting, risk analysis, project planning and control, and project improvement investment analysis. In this paper, we investigate the use of Fuzzy ID3 decision tree for software cost estimation; it is designed by integrating the principles of ID3 decision tree and the fuzzy set-theoretic concepts, enabling the model to handle uncertain and imprecise data when describing the software projects, which can improve greatly the accuracy of obtained estimates. MMRE and Pred are used as measures of prediction accuracy for this study. A series of experiments is reported using two different software projects datasets namely, Tukutuku and COCOMO'81 datasets. The results are compared with those produced by the crisp version of the ID3 decision tree.

  11. Mapping CMMI Level 2 to Scrum Practices: An Experience Report

    Science.gov (United States)

    Diaz, Jessica; Garbajosa, Juan; Calvo-Manzano, Jose A.

    CMMI has been adopted advantageously in large companies for improvements in software quality, budget fulfilling, and customer satisfaction. However SPI strategies based on CMMI-DEV require heavy software development processes and large investments in terms of cost and time that medium/small companies do not deal with. The so-called light software development processes, such as Agile Software Development (ASD), deal with these challenges. ASD welcomes changing requirements and stresses the importance of adaptive planning, simplicity and continuous delivery of valuable software by short time-framed iterations. ASD is becoming convenient in a more and more global, and changing software market. It would be greatly useful to be able to introduce agile methods such as Scrum in compliance with CMMI process model. This paper intends to increase the understanding of the relationship between ASD and CMMI-DEV reporting empirical results that confirm theoretical comparisons between ASD practices and CMMI level2.

  12. Exploring NASA OMI Level 2 Data With Visualization

    Science.gov (United States)

    Wei, Jennifer C.; Yang, Wenli; Johnson, James; Zhao, Peisheng; Gerasimov, Irina; Pham, Long; Vincente, Gilbert

    2014-01-01

    Satellite data products are important for a wide variety of applications that can bring far-reaching benefits to the science community and the broader society. These benefits can best be achieved if the satellite data are well utilized and interpreted, such as model inputs from satellite, or extreme events (such as volcano eruptions, dust storms, etc.).Unfortunately, this is not always the case, despite the abundance and relative maturity of numerous satellite data products provided by NASA and other organizations. Such obstacles may be avoided by allowing users to visualize satellite data as images, with accurate pixel-level (Level-2) information, including pixel coverage area delineation and science team recommended quality screening for individual geophysical parameters. We present a prototype service from the Goddard Earth Sciences Data and Information Services Center (GES DISC) supporting Aura OMI Level-2 Data with GIS-like capabilities. Functionality includes selecting data sources (e.g., multiple parameters under the same scene, like NO2 and SO2, or the same parameter with different aggregation methods, like NO2 in OMNO2G and OMNO2D products), user-defined area-of-interest and temporal extents, zooming, panning, overlaying, sliding, and data subsetting, reformatting, and reprojection. The system will allow any user-defined portal interface (front-end) to connect to our backend server with OGC standard-compliant Web Mapping Service (WMS) and Web Coverage Service (WCS) calls. This back-end service should greatly enhance its expandability to integrate additional outside data-map sources.

  13. Determine Operating Reactor to Use for the 2016 PCI Level 1 Milestone

    Energy Technology Data Exchange (ETDEWEB)

    Clarno, Kevin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-01-30

    The Consortium for Advanced Simulation of Light Water Reactors (LWRs) (CASL) Level 1 milestone to “Assess the analysis capability for core-wide [pressurized water reactor] PWR Pellet- Clad Interaction (PCI) screening and demonstrate detailed 3-D analysis on selected sub-region” (L1:CASL.P13.03) requires a particular type of nuclear power plant for the assessment. This report documents the operating reactor and cycles chosen for this assessment in completion of the physics integration (PHI) milestone to “Determine Operating Reactor to use for PCI L1 Milestone” (L3:PHI.CMD.P12.02). Watts Bar Unit 1 experienced (at least) one fuel rod failure in each of cycles 6 and 7, and at least one was deemed to be duty related rather than being primarily related to a manufacturing defect or grid effects. This brief report documents that the data required to model cycles 1–12 of Watts Bar Unit 1 using VERA-CS contains sufficient data to model the PHI portion of the PCI challenge problem. A list of additional data needs is also provided that will be important for verification and validation of the BISON results.

  14. Multiple routes and milestones in the folding of HIV-1 protease monomer.

    Directory of Open Access Journals (Sweden)

    Massimiliano Bonomi

    Full Text Available Proteins fold on a time scale incompatible with a mechanism of random search in conformational space thus indicating that somehow they are guided to the native state through a funneled energetic landscape. At the same time the heterogeneous kinetics suggests the existence of several different folding routes. Here we propose a scenario for the folding mechanism of the monomer of HIV-1 protease in which multiple pathways and milestone events coexist. A variety of computational approaches supports this picture. These include very long all-atom molecular dynamics simulations in explicit solvent, an analysis of the network of clusters found in multiple high-temperature unfolding simulations and a complete characterization of free-energy surfaces carried out using a structure-based potential at atomistic resolution and a combination of metadynamics and parallel tempering. Our results confirm that the monomer in solution is stable toward unfolding and show that at least two unfolding pathways exist. In our scenario, the formation of a hydrophobic core is a milestone in the folding process which must occur along all the routes that lead this protein towards its native state. Furthermore, the ensemble of folding pathways proposed here substantiates a rational drug design strategy based on inhibiting the folding of HIV-1 protease.

  15. A milestone-based approach to breast imaging instruction for residents.

    Science.gov (United States)

    Harvey, Jennifer A; Nicholson, Brandi T; Rochman, Carrie M; Peppard, Heather R; Pease, Clinton S; DeMartini, Nicholas A

    2014-06-01

    Residency is historically an apprenticeship, learning through observation and instruction with varying degrees of structure. Since July 2013, the Next Accreditation System (NAS) of the ACGME has required the use of progressive milestones for each radiology residency rotation. The authors describe how a breast imaging curriculum can be structured to comply with the NAS. The breast imaging rotations move from basic recognition and management of suspicious findings, through the detection of more subtle findings and learning of biopsy skills, and finally to the synthesis and management of more advanced findings. Likewise, patient communication moves from sharing imaging findings to the more challenging situation of breaking the bad news of a cancer diagnosis. This progression of skills mirrors the objectives of levels 1 to 4 of the NAS. Learning objectives have been adapted to form very specific milestones for each rotation, which results in a shared responsibility between residents and faculty members. Using clear expectations may improve the uniformity of teaching, resident satisfaction, and facilitate performance review for residents who are struggling. Didactic lectures, case-based conferences, teaching file cases, and assigned readings provide different approaches to education, allowing variation in learning styles. Performance on the breast imaging section on the ACR Diagnostic Radiology In-Training examination at our institution has risen from below the 50th percentile to around the 80th percentile beginning in 2011.

  16. FY17 CSSE L2 Milestone Report: Analyzing Power Usage Characteristics of Workloads Running on Trinity.

    Energy Technology Data Exchange (ETDEWEB)

    Pedretti, Kevin

    2017-09-01

    This report summarizes the work performed as part of a FY17 CSSE L2 milestone to in- vestigate the power usage behavior of ASC workloads running on the ATS-1 Trinity plat- form. Techniques were developed to instrument application code regions of interest using the Power API together with the Kokkos profiling interface and Caliper annotation library. Experiments were performed to understand the power usage behavior of mini-applications and the SNL/ATDM SPARC application running on ATS-1 Trinity Haswell and Knights Landing compute nodes. A taxonomy of power measurement approaches was identified and presented, providing a guide for application developers to follow. Controlled scaling study experiments were performed on up to 2048 nodes of Trinity along with smaller scale ex- periments on Trinity testbed systems. Additionally, power and energy system monitoring information from Trinity was collected and archived for post analysis of "in-the-wild" work- loads. Results were analyzed to assess the sensitivity of the workloads to ATS-1 compute node type (Haswell vs. Knights Landing), CPU frequency control, node-level power capping control, OpenMP configuration, Knights Landing on-package memory configuration, and algorithm/solver configuration. Overall, this milestone lays groundwork for addressing the long-term goal of determining how to best use and operate future ASC platforms to achieve the greatest benefit subject to a constrained power budget.

  17. Milestone Completion Report WBS 1.3.5.05 ECP/VTK-m FY17Q3 [MS-17/02] Faceted Surface Normals STDA05-3.

    Energy Technology Data Exchange (ETDEWEB)

    Moreland, Kenneth D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-07-01

    The FY17Q3 milestone of the ECP/VTK-m project includes the completion of a VTK-m filter that computes normal vectors for surfaces. Normal vectors are those that point perpendicular to the surface and are an important direction when rendering the surface. The implementation includes the parallel algorithm itself, a filter module to simplify integrating it into other software, and documentation in the VTK-m Users’ Guide. With the completion of this milestone, we are able to necessary information to rendering systems to provide appropriate shading of surfaces. This milestone also feeds into subsequent milestones that progressively improve the approximation of surface direction.

  18. 78 FR 8596 - Hartford Financial Services Group, Inc., Commercial/Actuarial/ Information Delivery Services (IDS...

    Science.gov (United States)

    2013-02-06

    .../ Information Delivery Services (IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Negative... Services Group, Inc., Commercial/Actuarial/Information Delivery Services (IDS)/Corporate & Financial... Hartford Financial Services Group, Inc., Commercial/Actuarial/Information Delivery Services...

  19. The FTK to Level-2 Interface Card (FLIC)

    CERN Document Server

    Anderson, John Thomas; The ATLAS collaboration; Blair, Robert; Drake, Gary; Love, Jeremy; Proudfoot, James; Wang, Rui; Zhang, Jinlong

    2015-01-01

    The FTK to Level-2 Interface Card (FLIC) of the ATLAS Fast TracKer (FTK) trigger upgrade is the final component in the FTK chain of custom electronics. The FTK performs full event tracking using the ATLAS Silicon detectors for every Level-1(L1) accepted event at 100 kHz. The FLIC is a custom Advanced Telecommunications Architecture (ATCA) card that interfaces the upstream FTK system with the ATLAS trigger and data acquisition (TDAQ) system, and allows for event processing on commercial PC blades making use of the 10 GB Ethernet full mesh ATCA back-plane. The FLIC receives data on 8 optical links at a bandwidth of about 1 Gbps per channel, reformats the data to the ATLAS standard record format, and performs the conversion from local to global module identifier using look up tables in SRAM. After processing, the event records are sent out to the TDAQ system using the S-LINK protocol at 2 Gbps, with a latency of O(10 microseconds). The data processing is handled in two Xilinx Virtex-6 FPGAs, with two additional ...

  20. The FTK to Level-2 Interface Card (FLIC)

    CERN Document Server

    Anderson, John Thomas; The ATLAS collaboration; Drake, Gary; Love, Jeremy; Proudfoot, James; Wang, Rui; Zhang, Jinlong; Auerbach, Benjamin

    2015-01-01

    The FTK to Level-2 Interface Card (FLIC) of the ATLAS Fast TracKer (FTK) trigger upgrade is the final component in the FTK chain of custom electronics. The FTK performs full event tracking using the ATLAS Silicon detectors for every Level-1 accepted event at 100 kHz. The FLIC is a custom Advanced Telecommunications Architecture (ATCA) card that interfaces the upstream FTK system with the ATLAS trigger and data acquisition (TDAQ) system, and allows for event processing on commercial PC blades making use of the 10 GB Ethernet full mesh ATCA back-plane. The FLIC receives data on 8 optical links at a bandwidth of ~1 Gbps per channel, reformats the data to the ATLAS standard record format, and performs the conversion from local to global module identifier using look up tables in SRAM. After processing, the event records are sent out to the TDAQ system using the S-LINK protocol at 2 Gbps, with a latency of O(10 microseconds). The data processing is handled in two Xilinx Virtex-6 FPGAs, with two additional Virtex-6 ...

  1. Online Muon Reconstruction in the ATLAS Level-2 trigger system

    CERN Document Server

    Di Mattia, A; Dos Anjos, A; Baines, J T M; Bee, C P; Biglietti, M; Bogaerts, J A C; Boisvert, V; Bosman, M; Caron, B; Casado, M P; Cataldi, G; Cavalli, D; Cervetto, M; Comune, G; Conde-Muíño, P; De Santo, A; Díaz-Gómez, M; Dosil, M; Ellis, Nick; Emeliyanov, D; Epp, B; Falciano, S; Farilla, A; George, S; Ghete, V M; González, S; Grothe, M; Kabana, S; Khomich, A; Kilvington, G; Konstantinidis, N P; Kootz, A; Lowe, A; Luci, C; Luminari, L; Maeno, T; Marzano, F; Masik, J; Meessen, C; Mello, A G; Merino, G; Moore, R; Morettini, P; Negri, A; Nikitin, N V; Nisati, A; Padilla, C; Panikashvili, N; Parodi, F; Pasqualucci, E; Pérez-Réale, V; Pinfold, J L; Pinto, P; Qian, Z; Resconi, S; Rosati, S; Sánchez, C; Santamarina-Rios, C; Scannicchio, D A; Schiavi, C; Segura, E; De Seixas, J M; Sivoklokov, S Yu; Soluk, R A; Stefanidis, E; Sushkov, S; Sutton, M; Tapprogge, Stefan; Thomas, E; Touchard, F; Venda-Pinto, B; Vercesi, V; Werner, P; Wheeler, S; Wickens, F J; Wiedenmann, W; Wielers, M; Zobernig, G; 2004 IEEE Nuclear Science Symposium And Medical Imaging Conference

    2004-01-01

    To cope with the 40 MHz event production rate of LHC, the trigger of the ATLAS experiment selects the events in three sequential steps of increasing complexity and accuracy whose final results are close to the offline reconstruction. The Level-1, implemented with custom hardware, identifies physics objects within Regions of Interests and operates a first reduction of the event rate to 75 KHz. The higher trigger levels provide a software based event selection which further reduces the event rate to about 100 Hz. This paper presents the algorithm (muFast) employed at Level-2 to confirm the muon candidates flagged by the Level-1. muFast identifies hits of muon tracks inside the Muon Spectrometer and provides a precise measurement of the muon momentum at the production vertex. The algorithm must process the Level-1 muon output rate (~20 KHz), thus a particular care has been used for its optimization. The result is a very fast track reconstruction algorithm with good physics performances which, in some cases, appr...

  2. Iron deficiency (ID) at both birth and 9 months predicts right frontal EEG asymmetry in infancy.

    Science.gov (United States)

    Armony-Sivan, Rinat; Zhu, Bingquan; Clark, Katy M; Richards, Blair; Ji, Chai; Kaciroti, Niko; Shao, Jie; Lozoff, Betsy

    2016-05-01

    This study considered effects of timing and duration of iron deficiency (ID) on frontal EEG asymmetry in infancy. In healthy term Chinese infants, EEG was recorded at 9 months in three experimental conditions: baseline, peek-a-boo, and stranger approach. Eighty infants provided data for all conditions. Prenatal ID was defined as low cord ferritin or high ZPP/H. Postnatal ID was defined as ≥ two abnormal iron measures at 9 months. Study groups were pre- and postnatal ID, prenatal ID only, postnatal ID only, and not ID. GLM repeated measure analysis showed a main effect for iron group. The pre- and postnatal ID group had negative asymmetry scores, reflecting right frontal EEG asymmetry (mean ± SE: -.18 ± .07) versus prenatal ID only (.00 ± .04), postnatal ID only (.03 ± .04), and not ID (.02 ± .04). Thus, ID at both birth and 9 months was associated with right frontal EEG asymmetry, a neural correlate of behavioral withdrawal and negative emotions.

  3. 6 CFR 37.25 - Renewal of REAL ID driver's licenses and identification cards.

    Science.gov (United States)

    2010-01-01

    ... SECRETARY REAL ID DRIVER'S LICENSES AND IDENTIFICATION CARDS Minimum Documentation, Verification, and Card Issuance Requirements § 37.25 Renewal of REAL ID driver's licenses and identification cards. (a) In-person renewals. States must require holders of REAL ID driver's licenses and identification cards to renew...

  4. 6 CFR 37.23 - Reissued REAL ID driver's licenses and identification cards.

    Science.gov (United States)

    2010-01-01

    ... SECRETARY REAL ID DRIVER'S LICENSES AND IDENTIFICATION CARDS Minimum Documentation, Verification, and Card Issuance Requirements § 37.23 Reissued REAL ID driver's licenses and identification cards. (a) State... time a REAL ID driver's license or identification card is reissued, to ensure that the...

  5. Picture This: How to Establish an Effective School ID Card Program

    Science.gov (United States)

    Finkelstein, David

    2013-01-01

    Most school districts do not have an ID card policy that everyone knows and follows, yet. many school districts are implementing ID card programs to address concerns about safety, efficiency, and convenience. A well-thought-out ID card program leads to greater security and smoother operations throughout the school and should thus be a priority.…

  6. People with ID as interviewers and co-researchers: experiences and reflection.

    NARCIS (Netherlands)

    Lieshout, H. van

    2012-01-01

    Aim: To share the experience of working with people with intellectual disabilities (ID) as interviewers in a qualitative study about community participation of people with ID. We reflect on two perspectives: the interviewers and the researchers. Method: Eighteen people with ID were interviewed by th

  7. A role for Id2 in regulating photic entrainment of the mammalian circadian system.

    Science.gov (United States)

    Duffield, Giles E; Watson, Nathan P; Mantani, Akio; Peirson, Stuart N; Robles-Murguia, Maricela; Loros, Jennifer J; Israel, Mark A; Dunlap, Jay C

    2009-02-24

    Inhibitor of DNA binding genes (Id1-Id4) encode helix-loop-helix (HLH) transcriptional repressors associated with development and tumorigenesis [1, 2], but little is known concerning the function(s) of these genes in normal adult animals. Id2 was identified in DNA microarray screens for rhythmically expressed genes [3-5], and further analysis revealed a circadian pattern of expression of all four Id genes in multiple tissues including the suprachiasmatic nucleus. To explore an in vivo function, we generated and characterized deletion mutations of Id2 and of Id4. Id2(-/-) mice exhibit abnormally rapid entrainment and an increase in the magnitude of the phase shift of the pacemaker. A significant proportion of mice also exhibit disrupted rhythms when maintained under constant darkness. Conversely, Id4(-/-) mice did not exhibit a noticeable circadian phenotype. In vitro studies using an mPer1 and an AVP promoter reporter revealed the potential for ID1, ID2, and ID3 proteins to interact with the canonical basic HLH clock proteins BMAL1 and CLOCK. These data suggest that the Id genes may be important for entrainment and operation of the mammalian circadian system, potentially acting through BMAL1 and CLOCK targets.

  8. The Id, the Ego and the Superego of The Simpsons

    OpenAIRE

    Stefán Birgir Stefánsson 1985

    2013-01-01

    The purpose of this essay is to explore three main characters from the popular television series The Simpsons in regards to Sigmund Freud’s theories in psychoanalytical analysis. This exploration is done because of great interest by the author and the lack of psychoanalytical analysis found connected to The Simpsons television show. The main aim is to show that these three characters, Homer Simpson, Marge Simpson and Ned Flanders, represent Freud’s three parts of the psyche, the id, the ego a...

  9. RFID and Auto-ID in planning and logistics

    CERN Document Server

    Jones, Erick C

    2011-01-01

    As RFID technology is becoming increasingly popular, the need has arisen to address the challenges and approaches to successful implementation. RFID and Auto-ID in Planning and Logistics: A Practical Guide for Military UID Applications presents the concepts for students, military personnel and contractors, and corporate managers to learn about RFID and other automatic information capture technologies, and their integration into planning and logistics functions. The text includes comparisons of RFID with technologies such as bar codes, satellite tags, and global positioning systems and provides

  10. Early developmental milestones and risk of schizophrenia: a 45-year follow-up of the Copenhagen Perinatal Cohort

    DEFF Research Database (Denmark)

    Sørensen, Holger J; Mortensen, Erik L; Schiffman, Jason

    2010-01-01

    disorders and in the 4982 cohort controls who were never admitted to a psychiatric department. Group comparisons were adjusted for gender, mother's age, father's age, parental social status, breadwinner's education, single mother status and parity. Individuals who developed schizophrenia reached all......The aim of the present study was to investigate the relationship between age of neuromotor milestone attainment and risk of adult schizophrenia. 5765 mothers of the Copenhagen Perinatal Cohort recorded 12 developmental milestones during the child's first year of life. Cohort members were followed...

  11. Gauging knowledge of developmental milestones among Albertan adults: a cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Tough Suzanne

    2010-04-01

    Full Text Available Abstract Background Parental knowledge of child development has been associated with more effective parenting strategies and better child outcomes. However, little is known about what adults who interact with children under the age of 14 years know about child development. Methods Between September 2007 and March 2008, computer assisted telephone interviews were completed with 1443 randomly selected adults. Adults were eligible if they had interacted with a child less than 14 years of age in the past six months and lived in Alberta, Canada. Results Sixty three percent of respondents answered two (or more out of four questions on physical development correctly. Fifteen percent of respondents answered two (or more out of three questions on cognitive development correctly. Seven percent of respondents answered three (or more out of five questions on social development correctly. Two percent of respondents answered three (or more out of five questions on emotional development correctly. Parents and females were better able to identify physical developmental milestones compared to non-parents and males. 81% of adults correctly responded that a child's experience in the first year of life has an important impact on later school performance, 70% correctly responded that a child's ability to learn is not set from birth, 50% of adults correctly responded that children learn more from hearing someone speak than from television, and 45% recognized that parents' emotional closeness with a baby influences later achievement. Parents were most likely to use doctors/paediatricians, books, and nurses as resources. Among parents, there was no relationship between knowledge and parenting morale. Conclusions The majority of adults were unable to correctly answer questions related to when children under six years of age typically achieve developmental milestones. Knowledge of physical development exceeded knowledge about cognitive, emotional and social development

  12. ATF3 suppresses ESCC via downregulation of ID1

    Science.gov (United States)

    Li, Jian; Yang, Zishan; Chen, Zhiuguo; Bao, Yonghua; Zhang, Huijuan; Fang, Xinhui; Yang, Wancai

    2016-01-01

    Esophageal cancer is one of the most prevalent forms of cancer and has a particularly high mortality rate due to early metastasis; however, the underlying mechanisms of its formation and progression remain unclear. The present study performed immunohistochemical analysis and observed that the expression of activating transcription factor 3 (ATF3) was reduced in esophageal squamous cell carcinoma (ESCC) in comparison with non-tumor adjacent tissues. By contrast, inhibitor of DNA binding 1 (ID1) was overexpressed in ESCC tissues, demonstrating an inverse correlation with ATF3 (P<0.01). In ESCC EC109 and KYSE450 cells lines, transfection with an ATF3-overexpression plasmid resulted in the inhibition of cell proliferation, motility and migration, which was associated with the induction of E-cadherin expression and inhibition of cyclin D1 and Twist. Notably, ATF3 exerted an inverse regulatory interaction with ID1. The results of the present study provide additional evidence of the tumor suppressive features of ATF3 and demonstrate a novel mechanism of ATF3-mediated inhibition of cancer metastasis in esophageal cancer. PMID:27602100

  13. Intrusion Detection System Inside Grid Computing Environment (IDS-IGCE

    Directory of Open Access Journals (Sweden)

    Basappa B. Kodada

    2012-01-01

    Full Text Available Grid Computing is a kind of important information technology which enables resource sharing globally to solve the large scale problem. It is based on networks and able to enable large scale aggregation and sharing of computational, data, sensors and other resources across institutional boundaries. Integrated Globus Tool Kit with Web services is to present OGSA (Open Grid Services Architecture as the standardservice grid architecture. In OGSA, everything is abstracted as a service, including computers, applications, data as well as instruments. The services and resources in Grid are heterogeneous and dynamic, and they also belong to different domains. Grid Services are still new to business system & asmore systems are being attached to it, any threat to it could bring collapse and huge harm. May be intruder come with a new form of attack. Grid Computing is a Global Infrastructure on the internet has led to asecurity attacks on the Computing Infrastructure. The wide varieties of IDS (Intrusion Detection System are available which are designed to handle the specific types of attacks. The technique of [27] will protect future attacks in Service Grid Computing Environment at the Grid Infrastructure but there is no technique can protect these types of attacks inside the grid at the node level. So this paper proposes the Architecture of IDS-IGCE (Intrusion Detection System – Inside Grid Computing Environment which can provide the protection against the complete threats inside the Grid Environment.

  14. Secure OpenID Authentication Model by Using Trusted Computing

    Directory of Open Access Journals (Sweden)

    E. Ghazizadeh

    2014-01-01

    Full Text Available The growth of Internet online services has been very quick in recent years. Each online service requires Internet users to create a new account to use the service. The problem can be seen when each user usually needs more than one service and, consequently, has numerous accounts. These numerous accounts have to be managed in a secure and simple way to be protected against identity theft. Single sign-on (SSO and OpenID have been used to decrease the complexity of managing numerous accounts required in the Internet identity environment. Trusted Platform Module (TPM and Trust Multitenancy are great trusted computing-based technologies to solve security concerns in the Internet identity environment. Since trust is one of the pillars of security in the cloud, this paper analyzes the existing cloud identity techniques in order to investigate their strengths and weaknesses. This paper proposes a model in which One Time Password (OTP, TPM, and OpenID are used to provide a solution against phishing as a common identity theft in cloud environment.

  15. Improvements of SMILES Level 2 products on ISAS/JAXA

    Science.gov (United States)

    Mitsuda, Chihiro; Suzuki, Makoto; Iwata, Yoshitaka; Manago, Naohiro; Takahashi, Chikako; Imai, Koji; Shiotani, Masato; Sano, Takuki; Takayanagi, Masahiro; Taniguchi, Hirotomo

    The Superconducting Submillimeter-wave Limb-Emission Sounder (SMILES),which was jointly developed by JAXA and NICT, had been launched and aboard the Japanese Experiment Mod-ule (JEM) of the International Space Station (ISS) in September, 2009. The SMILES carries 4 K-cooled Superconductor-Insulator-Superconductor (SIS) mixers to demonstrate a sensitive instrument for sub-millimeter limb sounding. SMILES system noise temperature (Tsys) is less than 500K (random noise ¡ 1 K). Since ISS has a non-sun-synchronous orbit, SMILES can observe diurnal variations of ClO, BrO, HO2 and mesospheric O3 etc. Standard L2 products, which are defined as O3, HCl, ClO, HNO3, CH3CN, HOCl, HO2, BrO, O3-isotopes on stratospheres, began to be released to RA PIs on January, 2010. The L2 data is currently 4 85 km, with 3 km interval (geometrical altitude) in HDF ver.5 file format similar to EOS-HDF including time, location etc.However, release data (ver. 005-06-0024) is a test version which is retrieved by prelaunch algorithms (Rodgers 1976. SMILES mission plan 2002. Takahashi et al., 2010. Imai et al., 2010.), and has some known issues. The one of the main issue is less product data. SMILES observes 1630 scans per a day. However, release products include only 60 percents of observation data. There are two reasons for this. The first is that antenna main beam is interfered by the ISS solar paddles. The second is that star tracker cameras, which determine SMILES observation points, are interfered by the Sun. In latter case, if we estimate the points by other information, geophysical parameters are retrieved since observed spectrums are useful. In new release data, we use both STT and ISS information and 80 percents of the data are included to products. In this presentation, we will introduce improvements of operational level 2 processing for new release product version.

  16. Duration of breastfeeding and developmental milestones during the latter half of infancy

    DEFF Research Database (Denmark)

    Vestergaard, Mogens; Obel, Carsten; Henriksen, Tine Brink

    1999-01-01

    Several studies have suggested that breastfeeding has a long-term influence on brain development. However, interpretation of these findings is complicated by the presence of many potential confounding factors. Only a few studies have examined infants before 1 y of age, although very early...... assessment might reduce the role of environmental influence. We investigated the association between exclusive breastfeeding and three developmental milestones related to general and fine motor skills and early language development at the age of 8 mo. We followed 1656 healthy, singleton, term infants......, with a birthweight of at least 2500 g, born between May 1991 and February 1992 in Aarhus, Denmark. Information was collected at 16 wk gestation, at delivery and when the infant was 8 mo old. Motor skills were evaluated by measurement of crawling and pincer grip. Early language development was defined as the ability...

  17. Project Milestone. Analysis of Range Extension Techniques for Battery Electric Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, Jeremy [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Wood, Eric [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Pesaran, Ahmad [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2013-07-01

    This report documents completion of the July 2013 milestone as part of NREL’s Vehicle Technologies Annual Operating Plan with the U.S. Department of Energy. The objective was to perform analysis on range extension techniques for battery electric vehicles (BEVs). This work represents a significant advancement over previous thru-life BEV analyses using NREL’s Battery Ownership Model, FastSim,* and DRIVE.* Herein, the ability of different charging infrastructure to increase achievable travel of BEVs in response to real-world, year-long travel histories is assessed. Effects of battery and cabin thermal response to local climate, battery degradation, and vehicle auxiliary loads are captured. The results reveal the conditions under which different public infrastructure options are most effective, and encourage continued study of fast charging and electric roadway scenarios.

  18. GTRF Calculations Using Hydra-TH (L3 Milestone THM.CFD.P5.05)

    Energy Technology Data Exchange (ETDEWEB)

    Bakosi, Jozsef [Los Alamos National Laboratory; Christon, Mark A. [Los Alamos National Laboratory; Francois, Marianne M. [Los Alamos National Laboratory; Lowrie, Robert B. [Los Alamos National Laboratory; Nourgaliev, Robert [Los Alamos National Laboratory

    2012-09-05

    This report describes the work carried out for completion of the Thermal Hydraulics Methods (THM) Level 3 Milestone THM.CFD.P5.05 for the Consortium for Advanced Simulation of Light Water Reactors (CASL). A series of body-fitted computational meshes have been generated by Numeca's Hexpress/Hybrid, a.k.a. 'Spider', meshing technology for the V5H 3 x 3 and 5 x 5 rod bundle geometries and subsequently used to compute the fluid dynamics of grid-to-rod fretting (GTRF). Spider is easy to use, fast, and automatically generates high-quality meshes for extremely complex geometries, required for the GTRF problem. Hydra-TH has been used to carry out large-eddy simulations on both 3 x 3 and 5 x 5 geometries, using different mesh resolutions. The results analyzed show good agreement with Star-CCM+ simulations and experimental data.

  19. A Milestone in China's Space History——The White Paper on China's Space Activities

    Institute of Scientific and Technical Information of China (English)

    Guo Baozhu

    2007-01-01

    The white paper document titled "China's Space Activities", released in November 2000 by the Information Office of the State Council, represents the first time for China to fully,systematically and publicly introduce to the world China's space development strategy and concerned policies .Its release is a milestone event in the country's space history, bearing great importance and profound influence to its future space efforts .The paper here describes the shaping processes of some important new ideas and concepts, including the connotative meaning of "space activities in a broad sense" and the roles and positions of different sectors in such activities .It also briefly discusses related policies concerning the country's space development and shortterm concepts and plans on its civil space activities.

  20. The Silicon Wheel of CMS-SiB1 Milestone Report

    CERN Document Server

    Wittmer, Bruno

    1998-01-01

    The CMS Silicon Barrel Detector is a subsystem of the CMS Tracker and consists of seven wheels. For the SiB1-Milestone, that was completed in Summer 1997, one of these wheels has been built and equipped with 14 working silicon microstrip detector modules and 112 dummy modules. The working modules consist of two detectors glued together each one having 1024 strips with a pitch of 50 micron that are read out by eight PreMux 128 Chips. In the dummy modules the Readout Electronics have been substituted by resistors simulating the heat load. The dummy silicon sensors have fiducial marks and were alligned with a precision of 5 micron. The supporting wheel structure is made out of carbon fiber and incorporates all services. The assembly precision of the support structure was better than 100 micron.

  1. Data co-processing for extreme scale analysis level II ASC milestone (4745).

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, David; Moreland, Kenneth D.; Oldfield, Ron A.; Fabian, Nathan D.

    2013-03-01

    Exascale supercomputing will embody many revolutionary changes in the hardware and software of high-performance computing. A particularly pressing issue is gaining insight into the science behind the exascale computations. Power and I/O speed con- straints will fundamentally change current visualization and analysis work ows. A traditional post-processing work ow involves storing simulation results to disk and later retrieving them for visualization and data analysis. However, at exascale, scien- tists and analysts will need a range of options for moving data to persistent storage, as the current o ine or post-processing pipelines will not be able to capture the data necessary for data analysis of these extreme scale simulations. This Milestone explores two alternate work ows, characterized as in situ and in transit, and compares them. We nd each to have its own merits and faults, and we provide information to help pick the best option for a particular use.

  2. Id3 induces an Elk-1–caspase-8-dependent apoptotic pathway in squamous carcinoma cells

    OpenAIRE

    Chen, You-Shin; Aubee, Joseph; Divito, Kyle A.; Zhou, Hengbo; Zhang, Weiyi; Chou, Fen-Pi; Simbulan-Rosenthal, Cynthia M.; Rosenthal, Dean S.

    2015-01-01

    Inhibitor of differentiation/DNA-binding (Id) proteins are helix–loop–helix (HLH) transcription factors. The Id protein family (Id1–Id4) mediates tissue homeostasis by regulating cellular processes including differentiation, proliferation, and apoptosis. Ids typically function as dominant negative HLH proteins, which bind other HLH proteins and sequester them away from DNA promoter regions. Previously, we have found that Id3 induced apoptosis in immortalized human keratinocytes upon UVB expos...

  3. Id4 Promotes Senescence and Sensitivity to Doxorubicin-induced Apoptosis in DU145 Prostate Cancer Cells

    OpenAIRE

    Carey, Jason P; Knowell, Ashley Evans; Chinaranagari, Swathi; Chaudhary, Jaideep

    2013-01-01

    Inhibitor of differentiation proteins (Id1, 2, 3 and 4) are dominant negative regulators of basic helix loop helix transcription factors and play dominant roles in cancer cells, spanning several molecular pathways including senescence, invasion, metastasis, proliferation and apoptosis. In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer. In the present study we demonstrated a novel role of Id4, that of promotion of cellular sene...

  4. Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice

    Directory of Open Access Journals (Sweden)

    Peng Zhou

    2016-01-01

    Full Text Available Inhibitor of DNA binding 2 (ID2 is a helix-loop-helix transcriptional repressor rhythmically expressed in many adult tissues. Our previous studies have demonstrated that Id2 null mice have sex-specific elevated glucose uptake in brown adipose tissue (BAT. Here we further explored the role of Id2 in the regulation of core body temperature over the circadian cycle and the impact of Id2 deficiency on genes involved in insulin signaling and adipogenesis in BAT. We discovered a reduced core body temperature in Id2−/− mice. Moreover, in Id2−/− BAT, 30 genes including Irs1, PPARs, and PGC-1s were identified as differentially expressed in a sex-specific pattern. These data provide valuable insights into the impact of Id2 deficiency on energy homeostasis of mice in a sex-specific manner.

  5. Comparison of Perinatal Risk Factors Associated with Autism Spectrum Disorder (ASD), Intellectual Disability (ID), and Co-Occurring ASD and ID

    Science.gov (United States)

    Schieve, Laura A.; Clayton, Heather B.; Durkin, Maureen S.; Wingate, Martha S.; Drews-Botsch, Carolyn

    2015-01-01

    While studies report associations between perinatal outcomes and both autism spectrum disorder (ASD) and intellectual disability (ID), there has been little study of ASD with versus without co-occurring ID. We compared perinatal risk factors among 7547 children in the 2006-2010 Autism and Developmental Disability Monitoring Network classified as…

  6. Comparison of Perinatal Risk Factors Associated with Autism Spectrum Disorder (ASD), Intellectual Disability (ID), and Co-Occurring ASD and ID

    Science.gov (United States)

    Schieve, Laura A.; Clayton, Heather B.; Durkin, Maureen S.; Wingate, Martha S.; Drews-Botsch, Carolyn

    2015-01-01

    While studies report associations between perinatal outcomes and both autism spectrum disorder (ASD) and intellectual disability (ID), there has been little study of ASD with versus without co-occurring ID. We compared perinatal risk factors among 7547 children in the 2006-2010 Autism and Developmental Disability Monitoring Network classified as…

  7. 20 CFR 411.581 - Can an EN receive milestone and outcome payments for months after a beneficiary takes his or her...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Can an EN receive milestone and outcome... Employment Network Payment Systems § 411.581 Can an EN receive milestone and outcome payments for months... assigned to an EN (or State VR agency acting as an EN) takes his or her ticket out of assignment (see §...

  8. 20 CFR 411.555 - Can the EN keep the milestone and outcome payments even if the beneficiary does not achieve all...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Can the EN keep the milestone and outcome... Payment Systems § 411.555 Can the EN keep the milestone and outcome payments even if the beneficiary does not achieve all outcome months? (a) Yes. The EN (or State VR agency acting as an EN) can keep...

  9. ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H.; Morton, Derrick J.; Patel, Divya; Joshi, Jugal; Upadhyay, Sunil; Chaudhary, Jaideep, E-mail: jchaudhary@cau.edu

    2016-09-09

    Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ectopic ID4 expression in DU145 attenuates proliferation and promotes AR expression suggesting that ID4 dependent AR activity is tumor suppressive. In this study, we examined the effect of ectopic expression of ID4 on highly malignant prostate cancer cell, PC3. Here we show that stable overexpression of ID4 in PC3 cells leads to increased apoptosis and decreased cell proliferation and migration. In addition, in vivo studies showed a decrease in tumor size and volume of ID4 overexpressing PC3 cells, in nude mice. At the molecular level, these changes were associated with increased androgen receptor (AR), p21, and AR dependent FKBP51 expression. At the mechanistic level, ID4 may regulate the expression or function of AR through specific but yet unknown AR co-regulators that may determine the final outcome of AR function. - Highlights: • ID4 expression induces AR expression in PC3 cells, which generally lack AR. • ID4 expression increased apoptosis and decreased cell proliferation and invasion. • Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo. • ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.

  10. Microbe-ID: an open source toolbox for microbial genotyping and species identification

    Directory of Open Access Journals (Sweden)

    Javier F. Tabima

    2016-08-01

    Full Text Available Development of tools to identify species, genotypes, or novel strains of invasive organisms is critical for monitoring emergence and implementing rapid response measures. Molecular markers, although critical to identifying species or genotypes, require bioinformatic tools for analysis. However, user-friendly analytical tools for fast identification are not readily available. To address this need, we created a web-based set of applications called Microbe-ID that allow for customizing a toolbox for rapid species identification and strain genotyping using any genetic markers of choice. Two components of Microbe-ID, named Sequence-ID and Genotype-ID, implement species and genotype identification, respectively. Sequence-ID allows identification of species by using BLAST to query sequences for any locus of interest against a custom reference sequence database. Genotype-ID allows placement of an unknown multilocus marker in either a minimum spanning network or dendrogram with bootstrap support from a user-created reference database. Microbe-ID can be used for identification of any organism based on nucleotide sequences or any molecular marker type and several examples are provided. We created a public website for demonstration purposes called Microbe-ID (microbe-id.org and provided a working implementation for the genus Phytophthora (phytophthora-id.org. In Phytophthora-ID, the Sequence-ID application allows identification based on ITS or cox spacer sequences. Genotype-ID groups individuals into clonal lineages based on simple sequence repeat (SSR markers for the two invasive plant pathogen species P. infestans and P. ramorum. All code is open source and available on github and CRAN. Instructions for installation and use are provided at https://github.com/grunwaldlab/Microbe-ID.

  11. Radikal konservativ idédebat og højreautoritær fascination i Danmark, ca. 1928-1940

    DEFF Research Database (Denmark)

    Holm, Adam

    1999-01-01

    Historie, Højreradikalisme, Konservatisme, Fascisme, Mellemkrigstid, Idéhistorie, Intellektuelle......Historie, Højreradikalisme, Konservatisme, Fascisme, Mellemkrigstid, Idéhistorie, Intellektuelle...

  12. Summary of FY 17 Assessments Sandia National Laboratories: Evaluation of FY16 SNL FCT M2 Milestone Deliverables

    Energy Technology Data Exchange (ETDEWEB)

    Appel, Gordon John

    2017-03-01

    This report is the milestone deliverable M4FT-17SN111102091 “Summary of Assessments Performed FY17 by SNL QA POC” for work package FT-17SN11110209 titled “Quality Assurance – SNL”. This report summarizes the FY17 assessment performed on Fuel Cycle Technologies / Spent Fuel and Waste Disposition efforts.

  13. Milestones in Medical Research, The Human Genome and ClinicalTrials.gov | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... turn Javascript on. Milestones in Medical Research, The Human Genome and ClinicalTrials.gov Past Issues / Fall 2010 Table of Contents Donald West King, M.D. FNLM ... genetic foundation of all human beings; the second, a comprehensive information service to ...

  14. Movement skill assessment in children with profound multiple disabilities : a psychometric analysis of the Top Down Motor Milestone Test

    NARCIS (Netherlands)

    van der Putten, A; Vlaskamp, C; Reynders, K; Nakken, H

    Objective: To analyse the psychometric properties of the Top Down Motor Milestone Test (TDMMT), an internationally used instrument in the planning and evaluation of movement-oriented interventions. Setting: Centres for special education in the Netherlands. Subjects: Children with profound multiple

  15. Health-related quality of life, developmental milestones, and self-esteem in young adults with bleeding disorders

    NARCIS (Netherlands)

    Limperg, P.F. (P. F.); L. Haverman (Lotte); H. Maurice-Stam (Heleen); M. Coppens; Valk, C. (C.); M.J.H.A. Kruip (Marieke); J.C.J. Eikenboom (Jeroen); M. Peters; M.A. Grootenhuis (Martha)

    2017-01-01

    textabstractBackground: The treatment of bleeding disorders improved in the last decades. However, the effect of growing up with bleeding disorders on developmental, emotional, and social aspects is understudied. Therefore, this study assesses HRQOL, developmental milestones, and self-esteem in

  16. Endorsement and Timing of Sexual Orientation Developmental Milestones Among Sexual Minority Young Adults in the Growing Up Today Study.

    Science.gov (United States)

    Katz-Wise, Sabra L; Rosario, Margaret; Calzo, Jerel P; Scherer, Emily A; Sarda, Vishnudas; Austin, S Bryn

    2017-02-01

    This research examined endorsement and timing of sexual orientation developmental milestones. Participants were 1,235 females and 398 males from the Growing Up Today Study, ages 22 to 29 years, who endorsed a sexual minority orientation (lesbian/gay, bisexual, mostly heterosexual) or reported same-gender sexual behavior (heterosexual with same-gender sexual experience). An online survey measured current sexual orientation and endorsement and timing (age first experienced) of five sexual orientation developmental milestones: same-gender attractions, other-gender attractions, same-gender sexual experience, other-gender sexual experience, and sexual minority identification. Descriptive analyses and analyses to test for gender and sexual orientation group differences were conducted. Results indicated that women were more likely than men to endorse same-gender attraction, other-gender attraction, and other-gender sexual experience, with the most gender differences in endorsement among mostly heterosexuals and heterosexuals with same-gender sexual experience. In general, men reached milestones earlier than women, with the most gender differences in timing among lesbian and gay individuals and heterosexuals with same-gender sexual experience. Results suggest that the three sexual minority developmental milestones may best characterize the experiences of lesbians, gay males, and female and male bisexuals. More research is needed to understand sexual orientation development among mostly heterosexuals and heterosexuals with same-gender sexual experience.

  17. The relationship of training milestones with racing success in a population of Standardbred horses in New Zealand.

    Science.gov (United States)

    Tanner, J C; Rogers, C W; Firth, E C

    2011-11-01

    To investigate the association between attainment of training milestones by 2-year-old horses with racing outcomes in a population of Standardbred racehorses in New Zealand. Retrospective records of the 2001/2002-born Standardbred foals were obtained. The three training milestones used were: registered with a trainer, entered in a trial, and competed in a race. The racing outcomes were length of career in years raced and number of race starts, and total earnings. Cox regression analysis was used to assess the association between attainment of the three milestones by 2-year-olds and the number of race starts and years raced. Logistic regression models were used to determine the association between attainment of the milestones by 2-year-olds and the outcomes won and placed in a race. Linear regression was used to model the association between attainment of the milestones by 2-year-olds and annual earnings and total earnings (transformed using Ln (earnings+NZ$100)). Of 3,032 horses in the population, 1,018 (33.6%) registered with a trainer, 609 (20.1%) trialled, and 272 (9.0%) raced as 2-year-olds. Horses that first raced as 2-year-olds had a longer racing career and more race starts than those that that did not race as 2-year-olds (pHorses that were registered with a trainer, trialled or raced as 2-year-olds were more likely to have won or placed in a race than those that did not achieve the milestones as 2-year-olds (phorses that trialled and raced as 2-year-olds had greater total earnings than those that did not, and male horses had a greater total earnings than female horses. Only one third the Standardbred racehorses born in 2001/2002 registered with a trainer as 2-year-olds, but the results of this study indicate that horses that began training, trialling, or racing as 2-year-olds had longer and more successful careers than those that did not achieve the milestones as 2-year-olds. Further investigation is required to quantify the management practices of these

  18. Predicting Students’ Performance using Modified ID3 Algorithm

    Directory of Open Access Journals (Sweden)

    Ramanathan L

    2013-06-01

    Full Text Available The ability to predict performance of students is very crucial in our present education system. We can use data mining concepts for this purpose. ID3 algorithm is one of the famous algorithms present today to generate decision trees. But this algorithm has a shortcoming that it is inclined to attributes with many values. So , this research aims to overcome this shortcoming of the algorithm by using gain ratio(instead of information gain as well as by giving weights to each attribute at every decision making point. Several other algorithms like J48 and Naive Bayes classification algorithm are alsoapplied on the dataset. The WEKA tool was used for the analysis of J48 and Naive Bayes algorithms. The results are compared and presented. The dataset used in our study is taken from the School of Computing Sciences and Engineering (SCSE, VIT University.

  19. Forensic validation of the SNPforID 52-plex assay

    DEFF Research Database (Denmark)

    Musgrave-Brown, Esther; Ballard, David; Balogh, Kinga

    2007-01-01

    The advantages of single nucleotide polymorphism (SNP) typing in forensic genetics are well known and include a wider choice of high-throughput typing platforms, lower mutation rates, and improved analysis of degraded samples. However, if SNPs are to become a realistic supplement to current short...... tandem repeat (STR) typing methods, they must be shown to successfully and reliably analyse the challenging samples commonly encountered in casework situations. The European SNPforID consortium, supported by the EU GROWTH programme, has developed a multiplex of 52 SNPs for forensic analysis...... in forensic casework. A total of 40 extracts were used in the study, each of which was sent to two of the five participating laboratories for typing in duplicate or triplicate. Laboratories were instructed to carry out their analyses as if they were dealing with normal casework samples. Results were reported...

  20. Applying Open Researchers and Contributors ID in scholarly journals

    Directory of Open Access Journals (Sweden)

    Jeonghee Im

    2015-02-01

    Full Text Available Open Researchers and Contributors ID (ORCID launched its registry services in October 2012. Consequently, adding personal information to the ORCID registry became routine work for researchers. To add ORCID to an online article, the tag needs to be included in the Journal Article Tag Suite extensible markup language file, if such a file has been produced by the publisher. Subsequently, all co-authors’ ORCID can be easily and conveniently collected and then integrated into the manuscript management system. In the current age of information and the Internet, journals need to keep pace with the surge of new standards and technologies. Editors should be able to accept and apply these new systems rapidly.

  1. ID-Check: Online Concealed Information Test Reveals True Identity.

    Science.gov (United States)

    Verschuere, Bruno; Kleinberg, Bennett

    2016-01-01

    The Internet has already changed people's lives considerably and is likely to drastically change forensic research. We developed a web-based test to reveal concealed autobiographical information. Initial studies identified a number of conditions that affect diagnostic efficiency. By combining these moderators, this study investigated the full potential of the online ID-check. Participants (n = 101) tried to hide their identity and claimed a false identity in a reaction time-based Concealed Information Test. Half of the participants were presented with personal details (e.g., first name, last name, birthday), whereas the others only saw irrelevant details. Results showed that participants' true identity could be detected with high accuracy (AUC = 0.98; overall accuracy: 86-94%). Online memory detection can reliably and validly detect whether someone is hiding their true identity. This suggests that online memory detection might become a valuable tool for forensic applications.

  2. Improvement of the ID model for quantitative network data

    DEFF Research Database (Denmark)

    Sørensen, Peter Borgen; Damgaard, Christian Frølund; Dupont, Yoko Luise

    2015-01-01

    )1. This presentation will illustrate the application of the ID method based on a data set which consists of counts of visits by 152 pollinator species to 16 plant species. The method is based on two definitions of the underlying probabilities for each combination of pollinator and plant species: (1), pi...... reproduce the high number of zero valued cells in the data set and mimic the sampling distribution. 1 Sørensen et al, Journal of Pollination Ecology, 6(18), 2011, pp129-139......Many interactions are often poorly registered or even unobserved in empirical quantitative networks. Hence, the output of the statistical analyses may fail to differentiate between patterns that are statistical artefacts and those which are real characteristics of ecological networks...

  3. Effectiveness of Iphone’s Touch ID: KSA Case Study

    Directory of Open Access Journals (Sweden)

    Ahmad A. Al-Daraiseh

    2015-01-01

    Full Text Available A new trend of incorporating Touch ID sensors in mobile devices is appearing. Last year, Apple released a new model of its famous iPhone (5s. One of the most anticipated and hailed features of the new device was its Touch ID. Apple advertised that the new technology will increase the security of its device, and it will also be used in different applications as a proof of identity. To make the issue more controversial, Apple announced a new financial service (Apple Pay that allows iPhone 6 users to use their iPhone as a replacement to credit cards. The minute the new technology was introduced; many questions appeared that needed immediate answers. Users were concerned about how it will work? Is it easy to use? Is it really safe? And whether it will be effective in protecting their private data or not? In this paper we provide a comprehensive study of this feature. We discuss the advantages and disadvantages of using it. Then we analyze and share the results of a survey that we conducted to measure the effectiveness of such feature in the Kingdom of Saudi Arabia (KSA. In this study, we only focus on users from KSA, because if the device fails to protect mobile’s data, severe consequences might happen. Due to cultural believes in KSA, releasing mobile contents to unauthorized people could lead to crimes. Survey analysis revealed somewhat controversial results, while 76% of all participants believe that this technology will improve the device security, only 33% use it to lock/unlock their devices, and even a smaller percentage use it to make purchases.

  4. Inhibitor of differentiation 4 (Id4 is a potential tumor suppressor in prostate cancer

    Directory of Open Access Journals (Sweden)

    Carey Jason PW

    2009-06-01

    Full Text Available Abstract Background Inhibitor of differentiation 4 (Id4, a member of the Id gene family is also a dominant negative regulator of basic helix loop helix (bHLH transcription factors. Some of the functions of Id4 appear to be unique as compared to its other family members Id1, Id2 and Id3. Loss of Id4 gene expression in many cancers in association with promoter hypermethylation has led to the proposal that Id4 may act as a tumor suppressor. In this study we provide functional evidence that Id4 indeed acts as a tumor suppressor and is part of a cancer associated epigenetic re-programming. Methods Data mining was used to demonstrate Id4 expression in prostate cancer. Methylation specific polymerase chain reaction (MSP analysis was performed to understand molecular mechanisms associated with Id4 expression in prostate cancer cell lines. The effect of ectopic Id4 expression in DU145 cells was determined by cell cycle analysis (3H thymidine incorporation and FACS, expression of androgen receptor, p53 and cyclin dependent kinase inhibitors p27 and p21 by a combination of RT-PCR, real time-PCR, western blot and immuno-cytochemical analysis. Results Id4 expression was down-regulated in prostate cancer. Id4 expression was also down-regulated in prostate cancer line DU145 due to promoter hyper-methylation. Ectopic Id4 expression in DU145 prostate cancer cell line led to increased apoptosis and decreased cell proliferation due in part by an S-phase arrest. In addition to S-phase arrest, ectopic Id4 expression in PC3 cells also resulted in prolonged G2/M phase. At the molecular level these changes were associated with increased androgen receptor (AR, p21, p27 and p53 expression in DU145 cells. Conclusion The results suggest that Id4 acts directly as a tumor suppressor by influencing a hierarchy of cellular processes at multiple levels that leads to a decreased cell proliferation and change in morphology that is possibly mediated through induction of previously

  5. Characterizing and Managing Intrusion Detection System (IDS) Alerts with Multi-Server/Multi-Priority Queuing Theory

    Science.gov (United States)

    2014-12-26

    IDS called SNORT®. ( Roesch & Green, 2014) .......... 3 Figure 2. A basic queuing theory diagram calling out the six defining characteristics of a...particular format is from the popular open source IDS called SNORT®. ( Roesch & Green, 2014) The set of signatures within an IDS is called its rule-set...nicol/ece541/slides/queueing.pdf Roesch , M., & Green, C. (2014). SNORT Users Manual. Retrieved August 2014, from SNORT: http://manual.snort.org/ Saad

  6. The Implementation of C-ID, R2D2 Model on Learning Reading Comprehension

    Science.gov (United States)

    Rayanto, Yudi Hari; Rusmawan, Putu Ngurah

    2016-01-01

    The purposes of this research are to find out, (1) whether C-ID, R2D2 model is effective to be implemented on learning Reading comprehension, (2) college students' activity during the implementation of C-ID, R2D2 model on learning Reading comprehension, and 3) college students' learning achievement during the implementation of C-ID, R2D2 model on…

  7. 6 CFR 37.29 - Prohibition against holding more than one REAL ID card or more than one driver's license.

    Science.gov (United States)

    2010-01-01

    ... ID card or more than one driver's license. 37.29 Section 37.29 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S LICENSES AND IDENTIFICATION CARDS Minimum... REAL ID card or more than one driver's license. (a) An individual may hold only one REAL ID card....

  8. A brief review of revocable ID-based public key cryptosystem

    Directory of Open Access Journals (Sweden)

    Tsu-Yang Wu

    2016-03-01

    Full Text Available The design of ID-based cryptography has received much attention from researchers. However, how to revoke the misbehaviour/compromised user in ID-based public key cryptosystem becomes an important research issue. Recently, Tseng and Tsai proposed a novel public key cryptosystem called revocable ID-based public key cryptosystem (RIBE to solve the revocation problem. Later on, numerous research papers based on the Tseng-Tsai key RIBE were proposed. In this paper, we brief review Tseng and Tsai's RIBE. We hope this review can help the readers to understand the Tseng and Tsai's revocable ID-based public key cryptosystem.

  9. Id expression in amphioxus and lamprey highlights the role of gene cooption during neural crest evolution

    Science.gov (United States)

    Meulemans, Daniel; McCauley, David; Bronner-Fraser, Marianne

    2003-01-01

    Neural crest cells are unique to vertebrates and generate many of the adult structures that differentiate them from their closest invertebrate relatives, the cephalochordates. Id genes are robust markers of neural crest cells at all stages of development. We compared Id gene expression in amphioxus and lamprey to ask if cephalochordates deploy Id genes at the neural plate border and dorsal neural tube in a manner similar to vertebrates. Furthermore, we examined whether Id expression in these cells is a basal vertebrate trait or a derived feature of gnathostomes. We found that while expression of Id genes in the mesoderm and endoderm is conserved between amphioxus and vertebrates, expression in the lateral neural plate border and dorsal neural tube is a vertebrate novelty. Furthermore, expression of lamprey Id implies that recruitment of Id genes to these cells occurred very early in the vertebrate lineage. Based on expression in amphioxus we postulate that Id cooption conferred sensory cell progenitor-like properties upon the lateral neurectoderm, and pharyngeal mesoderm-like properties upon cranial neural crest. Amphioxus Id expression is also consistent with homology between the anterior neurectoderm of amphioxus and the presumptive placodal ectoderm of vertebrates. These observations support the idea that neural crest evolution was driven in large part by cooption of multipurpose transcriptional regulators from other tissues and cell types.

  10. Idaho National Laboratory Supervisory Control and Data Acquisition Intrusion Detection System (SCADA IDS)

    Energy Technology Data Exchange (ETDEWEB)

    Jared Verba; Michael Milvich

    2008-05-01

    Current Intrusion Detection System (IDS) technology is not suited to be widely deployed inside a Supervisory, Control and Data Acquisition (SCADA) environment. Anomaly- and signature-based IDS technologies have developed methods to cover information technology-based networks activity and protocols effectively. However, these IDS technologies do not include the fine protocol granularity required to ensure network security inside an environment with weak protocols lacking authentication and encryption. By implementing a more specific and more intelligent packet inspection mechanism, tailored traffic flow analysis, and unique packet tampering detection, IDS technology developed specifically for SCADA environments can be deployed with confidence in detecting malicious activity.

  11. Achieving Payoffs from an Industry Cloud Ecosystem at BankID

    DEFF Research Database (Denmark)

    Eaton, Ben; Hallingby, Hanne Kristine; Nesse, Per-Jonny

    2014-01-01

    BankID is an industry cloud owned by Norwegian banks. It provides electronic identity, authentication and electronic signing capabilities for banking, merchant and government services. More than 60% of the population uses BankID services. As the broader ecosystem around BankID evolved, challenges......—arising from tensions between different parts of the ecosystem—had to be resolved. The four lessons learned from the BankID case will help others to build an industry cloud and establish a healthy ecosystem to service a broad user base....

  12. Colloidal nanocrystals for quality lighting and displays: milestones and recent developments

    Science.gov (United States)

    Erdem, Talha; Demir, Hilmi Volkan

    2016-06-01

    Recent advances in colloidal synthesis of nanocrystals have enabled high-quality high-efficiency light-emitting diodes, displays with significantly broader color gamut, and optically-pumped lasers spanning the whole visible regime. Here we review these colloidal platforms covering the milestone studies together with recent developments. In the review, we focus on the devices made of colloidal quantum dots (nanocrystals), colloidal quantum rods (nanorods), and colloidal quantum wells (nanoplatelets) as well as those of solution processed perovskites and phosphor nanocrystals. The review starts with an introduction to colloidal nanocrystal photonics emphasizing the importance of colloidal materials for light-emitting devices. Subsequently,we continue with the summary of important reports on light-emitting diodes, in which colloids are used as the color converters and then as the emissive layers in electroluminescent devices. Also,we review the developments in color enrichment and electroluminescent displays. Next, we present a summary of important reports on the lasing of colloidal semiconductors. Finally, we summarize and conclude the review presenting a future outlook.

  13. Colloidal nanocrystals for quality lighting and displays: milestones and recent developments

    Directory of Open Access Journals (Sweden)

    Erdem Talha

    2016-06-01

    Full Text Available Recent advances in colloidal synthesis of nanocrystals have enabled high-quality high-efficiency light-emitting diodes, displays with significantly broader color gamut, and optically-pumped lasers spanning the whole visible regime. Here we review these colloidal platforms covering the milestone studies together with recent developments. In the review, we focus on the devices made of colloidal quantum dots (nanocrystals, colloidal quantum rods (nanorods, and colloidal quantum wells (nanoplatelets as well as those of solution processed perovskites and phosphor nanocrystals. The review starts with an introduction to colloidal nanocrystal photonics emphasizing the importance of colloidal materials for light-emitting devices. Subsequently,we continue with the summary of important reports on light-emitting diodes, in which colloids are used as the color converters and then as the emissive layers in electroluminescent devices. Also,we review the developments in color enrichment and electroluminescent displays. Next, we present a summary of important reports on the lasing of colloidal semiconductors. Finally, we summarize and conclude the review presenting a future outlook.

  14. Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application

    Science.gov (United States)

    About, Imad

    2016-01-01

    Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties. Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade. Key milestone achievements have exemplified their clinical utility in Regenerative Dentistry, as surrogate therapeutic modules for conventional biomaterial-based approaches, offering regeneration of damaged oral tissues instead of simply “filling the gaps.” Thus, the essential next step to validate these immense advances is the implementation of well-designed clinical trials paving the way for exploiting these fascinating research achievements for patient well-being: the ultimate aim of this ground breaking technology. This review paper presents a concise overview of the major biological properties of the human dental MSCs, critical for the translational pathway “from bench to clinic.”

  15. Assessing EM Patient Safety and Quality Improvement Milestones Using a Novel Debate Format.

    Science.gov (United States)

    Mamtani, Mira; Scott, Kevin R; DeRoos, Francis J; Conlon, Lauren W

    2015-11-01

    Graduate medical education is increasingly focused on patient safety and quality improvement; training programs must adapt their curriculum to address these changes. We propose a novel curriculum for emergency medicine (EM) residency training programs specifically addressing patient safety, systems-based management, and practice-based performance improvement, called "EM Debates." Following implementation of this educational curriculum, we performed a cross-sectional study to evaluate the curriculum through resident self-assessment. Additionally, a cross-sectional study to determine the ED clinical competency committee's (CCC) ability to assess residents on specific competencies was performed. Residents were overall very positive towards the implementation of the debates. Of those participating in a debate, 71% felt that it improved their individual performance within a specific topic, and 100% of those that led a debate felt that they could propose an evidence-based approach to a specific topic. The CCC found that it was easier to assess milestones in patient safety, systems-based management, and practice-based performance improvement (sub-competencies 16, 17, and 19) compared to prior to the implementation of the debates. The debates have been a helpful venue to teach EM residents about patient safety concepts, identifying medical errors, and process improvement.

  16. Multiscale Estimation of Binding Kinetics Using Brownian Dynamics, Molecular Dynamics and Milestoning.

    Science.gov (United States)

    Votapka, Lane W; Amaro, Rommie E

    2015-10-01

    The kinetic rate constants of binding were estimated for four biochemically relevant molecular systems by a method that uses milestoning theory to combine Brownian dynamics simulations with more detailed molecular dynamics simulations. The rate constants found using this method agreed well with experimentally and theoretically obtained values. We predicted the association rate of a small charged molecule toward both a charged and an uncharged spherical receptor and verified the estimated value with Smoluchowski theory. We also calculated the kon rate constant for superoxide dismutase with its natural substrate, O2-, in a validation of a previous experiment using similar methods but with a number of important improvements. We also calculated the kon for a new system: the N-terminal domain of Troponin C with its natural substrate Ca2+. The kon calculated for the latter two systems closely resemble experimentally obtained values. This novel multiscale approach is computationally cheaper and more parallelizable when compared to other methods of similar accuracy. We anticipate that this methodology will be useful for predicting kinetic rate constants and for understanding the process of binding between a small molecule and a protein receptor.

  17. Multiscale Estimation of Binding Kinetics Using Brownian Dynamics, Molecular Dynamics and Milestoning.

    Directory of Open Access Journals (Sweden)

    Lane W Votapka

    2015-10-01

    Full Text Available The kinetic rate constants of binding were estimated for four biochemically relevant molecular systems by a method that uses milestoning theory to combine Brownian dynamics simulations with more detailed molecular dynamics simulations. The rate constants found using this method agreed well with experimentally and theoretically obtained values. We predicted the association rate of a small charged molecule toward both a charged and an uncharged spherical receptor and verified the estimated value with Smoluchowski theory. We also calculated the kon rate constant for superoxide dismutase with its natural substrate, O2-, in a validation of a previous experiment using similar methods but with a number of important improvements. We also calculated the kon for a new system: the N-terminal domain of Troponin C with its natural substrate Ca2+. The kon calculated for the latter two systems closely resemble experimentally obtained values. This novel multiscale approach is computationally cheaper and more parallelizable when compared to other methods of similar accuracy. We anticipate that this methodology will be useful for predicting kinetic rate constants and for understanding the process of binding between a small molecule and a protein receptor.

  18. Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application

    Directory of Open Access Journals (Sweden)

    Athina Bakopoulou

    2016-01-01

    Full Text Available Dental Mesenchymal Stem Cells (MSCs, including Dental Pulp Stem Cells (DPSCs, Stem Cells from Human Exfoliated Deciduous teeth (SHED, and Stem Cells From Apical Papilla (SCAP, have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties. Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade. Key milestone achievements have exemplified their clinical utility in Regenerative Dentistry, as surrogate therapeutic modules for conventional biomaterial-based approaches, offering regeneration of damaged oral tissues instead of simply “filling the gaps.” Thus, the essential next step to validate these immense advances is the implementation of well-designed clinical trials paving the way for exploiting these fascinating research achievements for patient well-being: the ultimate aim of this ground breaking technology. This review paper presents a concise overview of the major biological properties of the human dental MSCs, critical for the translational pathway “from bench to clinic.”

  19. Milestones of critical thinking: a developmental model for medicine and nursing.

    Science.gov (United States)

    Papp, Klara K; Huang, Grace C; Lauzon Clabo, Laurie M; Delva, Dianne; Fischer, Melissa; Konopasek, Lyuba; Schwartzstein, Richard M; Gusic, Maryellen

    2014-05-01

    Critical thinking is essential to a health professional's competence to assess, diagnose, and care for patients. Defined as the ability to apply higher-order cognitive skills (conceptualization, analysis, evaluation) and the disposition to be deliberate about thinking (being open-minded or intellectually honest) that lead to action that is logical and appropriate, critical thinking represents a "meta-competency" that transcends other knowledge, skills, abilities, and behaviors required in health care professions. Despite its importance, the developmental stages of critical thinking have not been delineated for nurses and physicians. As part of a task force of educators who considered different developmental stage theories, the authors have iteratively refined and proposed milestones in critical thinking. The attributes associated with unreflective, beginning, practicing, advanced, accomplished, and challenged critical thinkers are conceived as independent of an individual's level of training. Depending on circumstances and environmental factors, even the most experienced clinician may demonstrate attributes associated with a challenged thinker. The authors use the illustrative case of a patient with abdominal pain to demonstrate how critical thinking may manifest in learners at different stages of development, analyzing how the learner at each stage applies information obtained in the patient interaction to arrive at a differential diagnosis and plan for evaluation. The authors share important considerations and provide this work as a foundation for the development of effective approaches to teaching and promoting critical thinking and to establishing expectations for learners in this essential meta-competency.

  20. Nutrition factors predict earlier acquisition of motor and language milestones among young children in Haiti.

    Science.gov (United States)

    Iannotti, Lora; Jean Louis Dulience, Sherlie; Wolff, Patricia; Cox, Katherine; Lesorogol, Carolyn; Kohl, Patricia

    2016-09-01

    To examine the nutrition-related factors associated with motor and language development among young children living in a poor urban area of Haiti. Children aged 6-11 months (n = 583) were enrolled and followed monthly for one year. World Health Organization motor developmental milestones and vowel and consonant counts were assessed. Longitudinal regression models were applied to assess the association of anthropometric, dietary intake, infectious disease morbidity and socio-economic and demographic factors on developmental outcomes. At baseline, 9.4% were stunted or length-for-age Z score language acquisition at each time point during infancy. Several nutrition factors significantly predicted earlier achievement of motor and language development outcomes in longitudinal models: child anthropometry; breastfeeding and complementary feeding frequencies; dietary diversity; egg and oil intake; and reduced infectious disease morbidities. Increases in the length-for-age Z score significantly predicted all motor and language outcomes and yielded the best fit models compared to other anthropometric indicators (p < 0.001). Child development interventions may be enhanced by incorporating nutrition strategies such as improved diet quality, breastfeeding promotion and diarrhoeal disease mitigation. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  1. OUTLINING THE WINDOWS OF ACHIEVEMENT OF INTERSUBJECTIVE MILESTONES IN TYPICALLY DEVELOPING TODDLERS.

    Science.gov (United States)

    Sadurní Brugué, Marta; Pérez Burriel, Marc

    2016-07-01

    Babies are born with an innate drive or intrinsic motive formation with which to communicate and share meanings with others and that some authors have called intersubjectivity (S. Bråten & C. Trevarthen, 2007; C. Trevarthen, 1974, 2001). Around the ninth month of life, this motivation changes and passes from a person-to-person dyadic (primary intersubjectivity) to a person-person-object relationship (secondary intersubjectivity). S. Bråten and C. Trevarthen (2007) also proposed a third form or layer of intersubjectivity known as tertiary intersubjectivity. One hundred fifteen free-play sessions of 27 mother-child dyads (13 girls and 14 boys ages 9-37 months) were filmed and categorized using the Level of Intersubjective Attunement Scale (LISA-T; M. Pérez Burriel & M. Sadurní Brugué, 2014; M. Sadurní Brugué & M. Pérez Burriel, 2012). Results from these nine hierarchical levels are presented, following a developmental sequence or population trajectory around an interindividual variability. In this article, we propose viewing these age-related levels as windows of achievement of intersubjective milestones. The statistical analysis suggested a redesign of the LISA-T levels of intersubjectivity; thus, results from this redesign and the debate on the implications of these transitions in infant mental health development are presented.

  2. Extending the Developmental Milestones Checklist for use in a different context in Sub-Saharan Africa.

    Science.gov (United States)

    Prado, Elizabeth L; Abubakar, Amina A; Abbeddou, Souheila; Jimenez, Elizabeth Y; Somé, Jérôme W; Ouédraogo, Jean-Bosco

    2014-04-01

    Sub-Saharan Africa bears a disproportionate amount of global diseases related to neurodevelopmental delays in infancy, including malnutrition, malaria and HIV. Evaluating interventions to prevent such delays requires developmental assessment tools appropriate for Sub-Saharan Africa. This study aimed to develop and evaluate such a tool. The Developmental Milestones Checklist (DMC) was developed in Kenya to provide motor, language and personal-social scores for children aged from 3 to 24 months. We developed an extended version (DMC-II) in Burkina Faso, West Africa, and then evaluated the reliability and sensitivity of the scores to age and nutritional and environmental measures. The internal, interinterviewer and test-retest reliability of the DMC-II scores were >0.7. In 214 children aged 11.6-25.4 months, each score correlated with age (rs > 0.7). In 1123 children aged 16.8-19.9 months, the scores were sensitive to stunting, wasting and underweight (effect sizes 0.31-0.87 SD). The scores also showed expected correlations with measures of play materials in the home and activities with caregivers (rs = 0.13-0.41). The DMC-II is easily used by trained fieldworkers with no previous experience in developmental assessment. It is a practical, reliable and sensitive tool for evaluating motor, language and personal-social development in different contexts in Sub-Saharan Africa. ©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  3. The IJHPR publishes its 100th article, and other momentous milestones.

    Science.gov (United States)

    Rosen, Bruce; Israeli, Avi

    2013-12-19

    The Israel Journal of Health Policy Research (IJHPR) was launched in January 2012 and it is now publishing its 100th article. It was accepted into PubMed after only six months of publication and it has now also been accepted by Thomson Reuters for inclusion in the Web of Science as well as the Social Science Citation Index. It is rare for a new journal to reach these milestones at such an early stage in its development.One of the key factors in the journal's acceptance into these prestigious databases has been its unique national/international approach - exploring both what Israel can learn from health systems in other countries and what other countries can learn from Israeli health care. Another key factor has been its ability to attract high quality contributions from virtually all of the Israeli universities and research centers involved in health policy. A third important factor has been the journal's ability to engage leading international scholars as contributors and/or editorial board members.

  4. Highlights from e-EPS: New milestone reached for the European XFEL construction

    CERN Multimedia

    Jorge Rivero González

    2013-01-01

    e-EPS News is an addition to the CERN Bulletin line-up, showcasing articles from e-EPS – the European Physical Society newsletter – as part of a collaboration between the two publications.   In June 2013 an important milestone was reached for the European X-ray free-electron laser [XFEL] with the completion of its underground portion. Located in the Hamburg area (Germany), the European XFEL is one of the largest and most ambitious European projects to date. Starting full operations in 2016, the European XFEL is expected to generate intensive, ultrashort X-ray flashes that will open up entirely new areas of research with X-rays that are currently inaccessible. Organisations from 12 European countries, Denmark, France, Germany, Greece, Hungary, Italy, Poland, Russia, Slovakia, Spain, Sweden and Switzerland are members of the European XFEL consortium, with the Deutsches Elektronen-Synchrotron [DESY] as the main shareholder. The total length of the facility will be 3.4km and ...

  5. Molecular characterization of lactobacilli isolated from fermented idli batter

    Directory of Open Access Journals (Sweden)

    Perumal Jayaprabha Agaliya

    2013-12-01

    Full Text Available Lactic acid bacteria are non pathogenic organism widely distributed in nature typically involved in a large number of spontaneous food fermentation. The purpose of this study was to characterize the bacteriocinogenic lactobacilli from fermented idli batter which can find application in biopreservation and biomedicine. Eight most promising lactobacilli were chosen from twenty two isolates based on their spectrum of activity against other lactic acid bacteria and pathogens. The eight lactobacilli were characterized based on the various classical phenotypic tests, physiological tests and biochemical tests including various carbohydrate utilization profiles. All isolates were homo fermentative, catalase, and gelatin negative. Molecular characterization was performed by RAPD, 16S rRNA analysis, 16S ARDRA, and Multiplex PCR for species identification. RAPD was carried out using the primer R2 and M13. Five different clusters were obtained based on RAPD indicating strain level variation. 16S rRNA analysis showed 99 to 100% homology towards Lactobacillus plantarum. The restriction digestion pattern was similar for all the isolates with the restriction enzyme AluI. The subspecies were identified by performing Multiplex PCR using species specific primer. Among the five clusters, three clusters were clearly identified as Lactobacillus plantarum subsp. plantarum, Lactobacillus pentosus, and Lactobacillus plantarum subsp. argentoratensis.

  6. Molecular characterization of lactobacilli isolated from fermented idli batter.

    Science.gov (United States)

    Agaliya, Perumal Jayaprabha; Jeevaratnam, Kadirvelu

    2013-12-01

    Lactic acid bacteria are non pathogenic organism widely distributed in nature typically involved in a large number of spontaneous food fermentation. The purpose of this study was to characterize the bacteriocinogenic lactobacilli from fermented idli batter which can find application in biopreservation and biomedicine. Eight most promising lactobacilli were chosen from twenty two isolates based on their spectrum of activity against other lactic acid bacteria and pathogens. The eight lactobacilli were characterized based on the various classical phenotypic tests, physiological tests and biochemical tests including various carbohydrate utilization profiles. All isolates were homo fermentative, catalase, and gelatin negative. Molecular characterization was performed by RAPD, 16S rRNA analysis, 16S ARDRA, and Multiplex PCR for species identification. RAPD was carried out using the primer R2 and M13. Five different clusters were obtained based on RAPD indicating strain level variation. 16S rRNA analysis showed 99 to 100% homology towards Lactobacillus plantarum. The restriction digestion pattern was similar for all the isolates with the restriction enzyme AluI. The subspecies were identified by performing Multiplex PCR using species specific primer. Among the five clusters, three clusters were clearly identified as Lactobacillus plantarum subsp. plantarum, Lactobacillus pentosus, and Lactobacillus plantarum subsp. argentoratensis.

  7. L’idéologie : une notion bien embarrassante

    OpenAIRE

    Dominique Maingueneau

    2007-01-01

    Je ne pense pas être la personne la mieux placée pour réfléchir sur l’intérêt que présente la notion d’idéologie pour ceux qui étudient la littérature. Le travail conceptuel sur cette notion a plutôt été le fait de la génération antérieure à la mienne. Je suppose que si l’on m’a sollicité pour en parler, c’est parce que de l’intérieur de l’analyse du discours j’ai été amené à me confronter – quoique dans un cadre théorique et méthodologique très différent – à des questions du même ordre. Fau...

  8. Generating unique IDs from patient identification data using security models

    Directory of Open Access Journals (Sweden)

    Emad A Mohammed

    2016-01-01

    Full Text Available Background: The use of electronic health records (EHRs has continued to increase within healthcare systems in the developed and developing nations. EHRs allow for increased patient safety, grant patients easier access to their medical records, and offer a wealth of data to researchers. However, various bioethical, financial, logistical, and information security considerations must be addressed while transitioning to an EHR system. The need to encrypt private patient information for data sharing is one of the foremost challenges faced by health information technology. Method: We describe the usage of the message digest-5 (MD5 and secure hashing algorithm (SHA as methods for encrypting electronic medical data. In particular, we present an application of the MD5 and SHA-1 algorithms in encrypting a composite message from private patient information. Results: The results show that the composite message can be used to create a unique one-way encrypted ID per patient record that can be used for data sharing. Conclusion: The described software tool can be used to share patient EMRs between practitioners without revealing patients identifiable data.

  9. Application of Statistical Process Control Methods for IDS

    Directory of Open Access Journals (Sweden)

    Muhammad Sadiq Ali Khan

    2012-11-01

    Full Text Available As technology improves, attackers are trying to get access to the network system resources by so many means. Open loop holes in the network allow them to penetrate in the network more easily; statistical methods have great importance in the area of computer and network security, in detecting the malfunctioning of the network system. Development of internet security solution needed to protect the system and to with stand prolonged and diverse attack. In this paper Statistical approach has been used, conventionally Statistical Control Charts has been used for quality characteristics however in IDS abnormal access can be easily detected and appropriate control limit can be established. Two different charts are investigated and Shewhart chart based on average has produced better accuracy. The approach used here for intrusion detection in such a way that if the data packet is drastically different from normal variation then it can be classified as attack. In other words a system variation may be due to some special reason. If these causes are investigated then natural variation and abnormal variation can be distinguished which can be used for distinction of behaviors of the system.

  10. L’idéologie : une notion bien embarrassante

    Directory of Open Access Journals (Sweden)

    Dominique Maingueneau

    2007-02-01

    Full Text Available Je ne pense pas être la personne la mieux placée pour réfléchir sur l’intérêt que présente la notion d’idéologie pour ceux qui étudient la littérature. Le travail conceptuel sur cette notion a plutôt été le fait de la génération antérieure à la mienne. Je suppose que si l’on m’a sollicité pour en parler, c’est parce que de l’intérieur de l’analyse du discours j’ai été amené à me confronter – quoique dans un cadre théorique et méthodologique très différent – à des questions du même ordre. Faut...

  11. Precise Location Acquisition of Mobility Data Using Cell ID

    Directory of Open Access Journals (Sweden)

    Shafqat Ali Shad

    2012-05-01

    Full Text Available Cellular network data has become a hot source of study for extraction of user-mobility and spatio-temporal trends. Location binding in mobility data can be done through different methods like GPS, service provider assisted faux-GPS and Cell Global Identity (CGI. Among these Cell Global Identity is most inexpensive method and readily available solution for mobility extraction; however exact spatial extraction is somehow a problem in it. This paper presents the spatial extraction technique of mobile phone user raw data which carries the information like location information, proximity location and activity of subjects. This work mainly focuses on the data pre-processing methodology and technique to interpret the low level mobility data into high level mobility information using the designed clustering methodology and publically available Cell-IDs databases. Work proposed the semi- supervised strategy to derive the missing locations thorough the usage of semantic tag information and removal of spatial outliers for precise mobility profile building.

  12. Conventional Chiralpak ID vs. capillary Chiralpak ID-3 amylose tris-(3-chlorophenylcarbamate)-based chiral stationary phase columns for the enantioselective HPLC separation of pharmaceutical racemates.

    Science.gov (United States)

    Ahmed, Marwa; Gwairgi, Marina; Ghanem, Ashraf

    2014-11-01

    A comparative enantioselective analysis using immobilized amylose tris-(3-chlorophenylcarbamate) as chiral stationary phase in conventional high-performance liquid chromatography (HPLC) with Chiralpak ID (4.6 mm ID × 250 mm, 5 µm silica gel) and micro-HPLC with Chiralpak ID-3 (0.30 mm ID × 150 mm, 3 µm silica gel) was conducted. Pharmaceutical racemates of 12 pharmacological classes, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs, and antiarrhythmic drugs were screened under normal phase conditions. The effect of an organic modifier on the analyte retentions and enantiomer recognition was investigated. Baseline separation was achieved for 1-acenaphthenol, carprofen, celiprolol, cizolirtine carbinol, miconazole, tebuconazole, 4-hydroxy-3-methoxymandelic acid, 1-indanol, 1-(2-chlorophenyl)ethanol, 1-phenyl-2-propanol, flavanone, 6-hydroxyflavanone, 4-bromogluthethimide, and pentobarbital on the 4.6 mm ID packed with a 5 µm silica column using conventional HPLC. Nonetheless, baseline separation was achieved for aminoglutethimide, naftopidil, and thalidomide on the 0.3 mm ID packed with a 3 µm silica capillary column.

  13. Both Maternal and Pup Genotype Influence Ultrasonic Vocalizations and Early Developmental Milestones in Tsc2+/− Mice

    Directory of Open Access Journals (Sweden)

    Emily A. Greene-Colozzi

    2014-01-01

    Full Text Available Tuberous sclerosis complex (TSC is an autosomal dominant disorder characterized by tumor growth and neuropsychological symptoms such as autistic behavior, developmental delay, and epilepsy. While research has shed light on the biochemical and genetic etiology of TSC, the pathogenesis of the neurologic and behavioral manifestations remains poorly understood. TSC patients have a greatly increased risk of developmental delay and autism spectrum disorder, rendering the relationship between the two sets of symptoms an extremely pertinent issue for clinicians. We have expanded on previous observations of aberrant vocalizations in Tsc2+/− mice by testing vocalization output and developmental milestones systematically during the early postnatal period. In this study, we have demonstrated that Tsc2 haploinsufficiency in either dams or their pups results in a pattern of developmental delay in sensorimotor milestones and ultrasonic vocalizations.

  14. Development of ATC Tower Systems: Electronic Flight Strip System at LKPR and the Implementation of TAXI Milestone to SUM

    Directory of Open Access Journals (Sweden)

    Pavel Černý

    2016-10-01

    Full Text Available This article describes the Electronic Flight Strip System used at Václav Havel Airport Prague and presents the results of an analysis of the clearance input from ATCOs. The outcomes indicate that various clearances are frequently issued together in a common time frame, usually depending on the traffic flow structure. The focus then moves towards the implementation of the TAXI milestone into the Start-Up Manager. The used statistic methods indicate that the amount of TTOT recalculations after AOBT decreases, but not significantly. However, the accuracy of TTOT after TAXI clearance is considerably better. The mean and most common deviation of ATOT from TTOT after the implementation of TAXI milestone is -1 minute. The results are challenged and confirmed by a further analysis of the TTOT-ATOT difference regarding individual stand/RWY pairs. The results may be used to adjust the assumed taxi times.

  15. Assessment Report Sandia National Laboratories Fuel Cycle Technologies Quality Assurance Evaluation of FY15 SNL FCT M2 Milestone Deliverables

    Energy Technology Data Exchange (ETDEWEB)

    Appel, Gordon John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-05-01

    Sandia National Laboratories (SNL) Fuel Cycle Technologies (FCT) program activities are conducted in accordance with FCT Quality Assurance Program Document (FCT-QAPD) requirements. The FCT-QAPD interfaces with SNL approved Quality Assurance Program Description (SNL-QAPD) as explained in the Sandia National Laboratories QA Program Interface Document for FCT Activities (Interface Document). This plan describes SNL's FY16 assessment of SNL's FY15 FCT M2 milestone deliverable's compliance with program QA requirements, including SNL R&A requirements. The assessment is intended to confirm that SNL's FY15 milestone deliverables contain the appropriate authenticated review documentation and that there is a copy marked with SNL R&A numbers.

  16. Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.

    Directory of Open Access Journals (Sweden)

    April S Chan

    Full Text Available BACKGROUND: The bone-bone marrow interface is an area of the bone marrow microenvironment in which both bone remodeling cells, osteoblasts and osteoclasts, and hematopoietic cells are anatomically juxtaposed. The close proximity of these cells naturally suggests that they interact with one another, but these interactions are just beginning to be characterized. METHODOLOGY/PRINCIPAL FINDINGS: An Id1(-/- mouse model was used to assess the role of Id1 in the bone marrow microenvironment. Micro-computed tomography and fracture tests showed that Id1(-/- mice have reduced bone mass and increased bone fragility, consistent with an osteoporotic phenotype. Osteoclastogenesis and pit formation assays revealed that loss of Id1 increased osteoclast differentiation and resorption activity, both in vivo and in vitro, suggesting a cell autonomous role for Id1 as a negative regulator of osteoclast differentiation. Examination by flow cytometry of the hematopoietic compartment of Id1(-/- mice showed an increase in myeloid differentiation. Additionally, we found increased expression of osteoclast genes, TRAP, Oscar, and CTSK in the Id1(-/- bone marrow microenvironment. Lastly, transplantation of wild-type bone marrow into Id1(-/- mice repressed TRAP, Oscar, and CTSK expression and activity and rescued the hematopoietic and bone phenotype in these mice. CONCLUSIONS/SIGNIFICANCE: In conclusion, we demonstrate an osteoporotic phenotype in Id1(-/- mice and a mechanism for Id1 transcriptional control of osteoclast-associated genes. Our results identify Id1 as a principal player responsible for the dynamic cross-talk between bone and bone marrow hematopoietic cells.

  17. Isolating the Role of Psychological Dysfunction in Smoking Cessation Failure: Relations of Personality and Psychopathology to Attaining Smoking Cessation Milestones

    Science.gov (United States)

    Leventhal, Adam M.; Japuntich, Sandra J.; Piper, Megan E.; Jorenby, Douglas E.; Schlam, Tanya R.; Baker, Timothy B.

    2012-01-01

    Research exploring psychological dysfunction as a predictor of smoking cessation success may be limited by nonoptimal predictor variables (i.e., categorical psychodiagnostic measures vs. continuous personality-based manifestations of dysfunction) and imprecise outcomes (i.e., summative point prevalence abstinence vs. constituent cessation milestone measures). Accordingly, this study evaluated the unique and overlapping relations of broad-spectrum personality traits (positive emotionality, negative emotionality, and constraint) and past-year psychopathology (anxiety, mood, and substance use disorder) to point prevalence abstinence and three smoking cessation milestones: (1) initiating abstinence; (2) first lapse; and (3) transition from lapse to relapse. Participants were daily smokers (N=1365) enrolled in a smoking cessation treatment study. In single predictor regression models, each manifestation of internalizing dysfunction (lower positive emotionality, higher negative emotionality, and anxiety and mood disorder) predicted failure at one or more cessation milestone. In simultaneous predictor models, lower positive and higher negative emotionality significantly predicted failure to achieve milestones after controlling for psychopathology. Psychopathology did not predict any outcome when controlling for personality. Negative emotionality showed the most robust and consistent effects, significantly predicting failure to initiate abstinence, earlier lapse, and lower point prevalence abstinence rates. Substance use disorder and constraint did not predict cessation outcomes, and no single variable predicted lapse-to-relapse transition. These findings suggest that personality-related manifestations of internalizing dysfunction are more accurate markers of affective sources of relapse risk than mood and anxiety disorders. Further, individuals with high trait negative emotionality may require intensive intervention to promote the initiation and early maintenance of

  18. Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder.

    Science.gov (United States)

    Uljarević, Mirko; Hedley, Darren; Alvares, Gail A; Varcin, Kandice J; Whitehouse, Andrew J O

    2017-03-16

    This study explored the relationships between the later age of achievement of early motor milestones, current motor atypicalities (toe walking), and the severity of restricted and repetitive behaviors (RRBs) in individuals with autism spectrum disorder (ASD). Parents of 147 children and adolescents with ASD (Mage  = 8.09 years, SD = 4.28; 119 males) completed an early developmental milestones questionnaire and the Social Responsiveness Scale as a measure of Insistence on Sameness (IS) and Repetitive Mannerisms (RM). Two hierarchical regression analyses were conducted to test whether RM and IS behaviors were predicted by early motor milestones, or current toe walking. The final model predicting RM accounted for 15% of the variance (F = 3.02, p = .009), with toe walking as a unique and independent predictor of RM scores (t = 3.568, p = .001). The final model predicting IS accounted for 19.1% of variance in IS scores (F = 4.045, p = .001), with chronological age (CA) (t = 2.92, p = .004), age when first standing (t = 2.09, p = .038), and toe walking (t = 2.53, p = .013) as unique independent predictors. Toe walking (t = 2.4, p = .018) and age when first sitting (t = 2.08, p = .04) predicted the severity of RRBs on the Autism Diagnostic Observation Schedule (F = 2.334, p = .036). Our study replicates previous findings on the relationship between concurrent motor impairments and RRBs, and provides the first evidence for the association between RRBs and age of attainment of early motor milestones. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

  19. Maternal pre-pregnancy obesity and achievement of infant motor developmental milestones in the Upstate KIDS Study

    OpenAIRE

    Wylie, Amanda; Sundaram, Rajeshwari; Kus, Christopher; Ghassabian, Akhgar; Yeung, Edwina H.

    2015-01-01

    Objective Maternal pre-pregnancy obesity is associated with several poor infant health outcomes; however studies that investigated motor development have been inconsistent. Thus, we examined maternal pre-pregnancy weight status and infants’ gross motor development. Design and Methods Participants consisted of 4,901 mother-infant pairs from the Upstate KIDS study, a longitudinal cohort in New York. Mothers indicated dates when infants achieved each of six gross motor milestones when infants we...

  20. Where do we go from here? Moving from systems-based practice process measures to true competency via developmental milestones

    Directory of Open Access Journals (Sweden)

    Johanna Martinez

    2014-06-01

    Full Text Available For many educators it has been challenging to meet the Accreditation Council for Graduate Medical Education's requirements for teaching systems-based practice (SBP. An additional layer of complexity for educators is evaluating competency in SBP, despite milestones and entrustable professional activities (EPAs. In order to address this challenge, the authors present the results of a literature review for how SBP is currently being taught and a series of recommendations on how to achieve competency in SBP for graduate medical trainees with the use of milestones. The literature review included 29 articles and demonstrated that only 28% of the articles taught more than one of the six core principles of SBP in a meaningful way. Only 7% of the articles received the highest grade of A. The authors summarize four guiding principles for creating a competency-based curriculum that is in alignment with the Next Accreditation System (NAS: 1 the curriculum needs to include all of the core principles in that competency, 2 the objectives of the curriculum should be driven by clinical outcomes, 3 the teaching modalities need to be interactive and clinically relevant, and 4 the evaluation process should be able to measure competency and be directly reflective of pertinent milestones and/or EPAs. This literature review and the provided guiding principles can guide other residency educators in their development of competency-based curricula that meets the standards of the NAS.

  1. Driving Care Quality: Aligning Trainee Assessment and Supervision Through Practical Application of Entrustable Professional Activities, Competencies, and Milestones.

    Science.gov (United States)

    Carraccio, Carol; Englander, Robert; Holmboe, Eric S; Kogan, Jennifer R

    2016-02-01

    To address the long-standing challenge of meaningful trainee assessment, the authors reviewed and expanded on the Accountable Assessment for Quality Care and Supervision (AAQCS) equation. The equation proposes that care quality is the product of the interaction between trainee performance (measured by workplace assessment) and supervision (required level of intervention to ensure care quality) in the context of the environment where the care occurs: Trainee performance × Appropriate supervision = Safe, effective patient-centered care. Assessing trainee performance and matching that performance to "appropriate" supervision, however, is fraught with challenges. The authors suggest a unifying framework that integrates entrustable professional activities (EPAs), competencies, and milestones to inform trainee assessment and supervision, thereby enabling the practical application of the AAQCS equation in the workplace. Because the unit of measure for an EPA is the outcome of whether the trainee can safely and effectively perform the professional activity without supervision, the proposed unifying framework directly aligns with the dependent variable in the AAQCS equation: care quality.The value of applying a unifying framework that integrates EPAs, competencies, and milestones to the AAQCS equation in the clinical learning environment lies in its ability to provide supervisors with a shared mental model of performance expectations for trainees, reducing unwanted variability and improving assessment accuracy; guidance for aligning performance milestones of trainees with the needed level of supervisor intervention to ensure care quality; and substrate for specific feedback to improve the trainee's professional development as a way to ensure future care quality.

  2. Norms for developmental milestones using VABS-II and association with anthropometric measures among apparently healthy urban Indian preschool children.

    Science.gov (United States)

    Selvam, Sumithra; Thomas, Tinku; Shetty, Priya; Zhu, Jianjun; Raman, Vijaya; Khanna, Deepti; Mehra, Ruchika; Kurpad, Anura V; Srinivasan, Krishnamachari

    2016-12-01

    Assessment of developmental milestones based on locally developed norms is critical for accurate estimate of overall development of a child's cognitive, behavioral, social, and emotional development. A cross-sectional study was done to develop age specific norms for developmental milestones using Vineland Adaptive Behavior Scales (VABS-II) (Sparrow, Cicchetti, & Balla, 2005) for apparently healthy children from 2 to 5 years from urban Bangalore, India, and to examine its association with anthropometric measures. Mothers (or caregivers) of 412 children participated in the study. Age-specific norms using inferential norming method and adaptive levels for all domains and subdomains were derived. Low adaptive level, also called delayed developmental milestone, was observed in 2.3% of the children, specifically 2.7% in motor and daily living skills and 2.4% in communication skills. When these children were assessed on the existing U.S. norms, there was a significant overestimation of delayed development in socialization and motor skills, whereas delay in communication and daily living skills were underestimated (all p VABS-II in preschool children, the prevalence of developmental delay could either be under- or overestimated using Western norms. Thus, locally referenced norms are critical for reliable assessments of development in children. Stunted and underweight children are more likely to have poorer developmental scores compared with healthy children. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  3. 75 FR 22695 - Establishment of Class E Airspace; Bonners Ferry, ID

    Science.gov (United States)

    2010-04-30

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Bonners Ferry, ID AGENCY... E airspace at Bonners Ferry, ID, to accommodate aircraft using a new Area Navigation (RNAV) Global... improve the safety and management of Instrument Flight Rules (IFR) operations at the airport. DATES...

  4. The Mathematica package TopoID and its application to the Higgs boson production cross section

    Energy Technology Data Exchange (ETDEWEB)

    Hoff, Jens

    2016-07-15

    We present the Mathematica package TopoID which aims at the automation of several steps in multiloop calculations. The algorithm which lies at the very core of the package is described and illustrated with an example. The main features of TopoID are stated and some of them are briefly demonstrated for NLO or NNLO Higgs boson production.

  5. Id2a is required for hepatic outgrowth during liver development in zebrafish.

    Science.gov (United States)

    Khaliq, Mehwish; Choi, Tae-Young; So, Juhoon; Shin, Donghun

    2015-11-01

    During development, inhibitor of DNA binding (Id) proteins, a subclass of the helix-loop-helix family of proteins, regulate cellular proliferation, differentiation, and apoptosis in various organs. However, a functional role of Id2a in liver development has not yet been reported. Here, using zebrafish as a model organism, we provide in vivo evidence that Id2a regulates hepatoblast proliferation and cell death during liver development. Initially, in the liver, id2a is expressed in hepatoblasts and after their differentiation, id2a expression is restricted to biliary epithelial cells. id2a knockdown in zebrafish embryos had no effect on hepatoblast specification or hepatocyte differentiation. However, liver size was greatly reduced in id2a morpholino-injected embryos, indicative of a hepatic outgrowth defect attributable to the significant decrease in proliferating hepatoblasts concomitant with the significant increase in hepatoblast cell death. Altogether, these data support the role of Id2a as an important regulator of hepatic outgrowth via modulation of hepatoblast proliferation and survival during liver development in zebrafish.

  6. Manual of spIds, a software package for parameter identification in dynamic systems

    NARCIS (Netherlands)

    Everaars, C.T.H.; Hemker, P.W.; Stortelder, W.J.H.

    1995-01-01

    This report contains the manual of spIds, version 1.0, a software package for parameter identification in dynamic systems. SpIdslabel{ab:spIds is an acronym of underline{simulation and underline{parameter underline{identification in underline{dynamic underline {systems. It can be applied on wide var

  7. 81 FR 16198 - Deer Flat National Wildlife Refuge, Canyon, Payette, Owyhee, and Washington Counties, ID, and...

    Science.gov (United States)

    2016-03-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service Deer Flat National Wildlife Refuge, Canyon, Payette, Owyhee, and Washington..., 1010 Dearborn St., Caldwell, ID 83605. Homedale Public Library, 125 W Owyhee Ave., Homedale, ID...

  8. 75 FR 41232 - Deer Flat National Wildlife Refuge, Canyon, Owyhee, Payette, and Washington Counties, ID; Malheur...

    Science.gov (United States)

    2010-07-15

    ... Fish and Wildlife Service Deer Flat National Wildlife Refuge, Canyon, Owyhee, Payette, and Washington...). The Refuge has units located in Canyon, Owyhee, Payette, and Washington Counties, ID, and Malheur... the Snake River located in Canyon, Payette, Owyhee, and Washington Counties in ID; and Malheur...

  9. Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

    DEFF Research Database (Denmark)

    Gibbs-Seymour, Ian; Oka, Yasuyoshi; Rajendra, Eeson

    2015-01-01

    We show that central components of the Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID complex), are SUMOylated in response to replication fork stalling. The ID complex is SUMOylated in a manner that depends on the ATR kinase, the FA ubiquitin ligase...

  10. 75 FR 47515 - Identification (ID) Cards for Members of the Uniformed Services, Their Dependents, and Other...

    Science.gov (United States)

    2010-08-06

    ... Services, Their Dependents, and Other Eligible Individuals AGENCY: Office of the Under Secretary of Defense... DoD ID cards. The ID cards shall be issued to uniformed service members, their dependents, and other.... The general policy for comments and other submissions from members of the public is to make...

  11. Wicked ID: Conceptual Framework for Considering Instructional Design as a Wicked Problem

    Science.gov (United States)

    Becker, Katrin

    2007-01-01

    The process of instructional design has parallels in other design disciplines. Software design is one that has experienced intense attention in the last 30 or so years, and many lessons learned there can be applied to ID. Using software design as a springboard, this concept paper seeks to propose a new approach to ID. It suggests that…

  12. The ID23-2 structural biology microfocus beamline at the ESRF

    Energy Technology Data Exchange (ETDEWEB)

    Flot, David, E-mail: flot@esrf.fr [European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, 38042 Grenoble (France); Mairs, Trevor; Giraud, Thierry; Guijarro, Matias; Lesourd, Marc; Rey, Vicente; Brussel, Denis van; Morawe, Christian; Borel, Christine; Hignette, Olivier; Chavanne, Joel; Nurizzo, Didier; McSweeney, Sean; Mitchell, Edward [European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 181, 38043 Grenoble (France)

    2010-01-01

    Beamline ID23-2, the first dedicated and highly automated high-throughput monochromatic macromolecular crystallography microfocus beamline, is described. The first phase of the ESRF beamline ID23 to be constructed was ID23-1, a tunable MAD-capable beamline which opened to users in early 2004. The second phase of the beamline to be constructed is ID23-2, a monochromatic microfocus beamline dedicated to macromolecular crystallography experiments. Beamline ID23-2 makes use of well characterized optical elements: a single-bounce silicon (111) monochromator and two mirrors in Kirkpatrick–Baez geometry to focus the X-ray beam. A major design goal of the ID23-2 beamline is to provide a reliable, easy-to-use and routine microfocus beam. ID23-2 started operation in November 2005, as the first beamline dedicated to microfocus macromolecular crystallography. The beamline has taken the standard automated ESRF macromolecular crystallography environment (both hardware and software), allowing users of ID23-2 to be rapidly familiar with the microfocus environment. This paper describes the beamline design, the special considerations taken into account given the microfocus beam, and summarizes the results of the first years of the beamline operation.

  13. Extending the Intermediate Data Structure (IDS for longitudinal historical databases to include geographic data

    Directory of Open Access Journals (Sweden)

    Finn Hedefalk

    2014-09-01

    Full Text Available The Intermediate Data Structure (IDS is a standardised database structure for longitudinal historical databases. Such a common structure facilitates data sharing and comparative research. In this study, we propose an extended version of IDS, named IDS-Geo, that also includes geographic data. The geographic data that will be stored in IDS-Geo are primarily buildings and/or property units, and the purpose of these geographic data is mainly to link individuals to places in space. When we want to assign such detailed spatial locations to individuals (in times before there were any detailed house addresses available, we often have to create tailored geographic datasets. In those cases, there are benefits of storing geographic data in the same structure as the demographic data. Moreover, we propose the export of data from IDS-Geo using an eXtensible Markup Language (XML Schema. IDS-Geo is implemented in a case study using historical property units, for the period 1804 to 1913, stored in a geographically extended version of the Scanian Economic Demographic Database (SEDD. To fit into the IDS-Geo data structure, we included an object lifeline representation of all of the property units (based on the snapshot time representation of single historical maps and poll-tax registers. The case study verifies that the IDS-Geo model is capable of handling geographic data that can be linked to demographic data.

  14. Sexual abuse involving children with an intellectual disability (ID): a narrative review

    NARCIS (Netherlands)

    Wissink, I.B.; van Vugt, E.S.; Moonen, X.; Stams, G.J.J.M.; Hendriks, J.

    2015-01-01

    The current paper provides a narrative review of the literature on sexual abuse, involving children with Intellectual Disability (ID). The thirteen articles that were found and met our criteria vary in their definitions of sexual abuse and in how ID was determined. Still, they do paint a general pic

  15. Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis.

    Science.gov (United States)

    Shin, Dong-Hui; Park, Ji-Hye; Lee, Jeong-Yeon; Won, Hee-Young; Jang, Ki-Seok; Min, Kyueng-Whan; Jang, Si-Hyong; Woo, Jong-Kyu; Oh, Seung Hyun; Kong, Gu

    2015-07-10

    Inhibitor of differentiation/DNA binding (Id)1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) activities in transgenic mice. MaSC-enriched basal cell expansion and increased self-renewal and in vivo regenerative capacity of MaSCs are observed in the mammary glands of MMTV-Id1 transgenic mice. Furthermore, MMTV-Id1 mice develop ductal hyperplasia and mammary tumors with highly expressed basal markers. Id1 also increases breast cancer stem cell (CSC) population and activity in human breast cancer lines. Moreover, the effects of Id1 on normal and malignant stem cell activities are mediated by the Wnt/c-Myc pathway. Collectively, these findings provide in vivo genetic evidence of Id1 functions as an oncogene in breast cancer and indicate that Id1 regulates mammary basal stem cells by activating the Wnt/c-Myc pathway, thereby contributing to breast tumor development.

  16. Cloning and shake flask expression of hrIDS-Like in Pichia pastoris

    African Journals Online (AJOL)

    STORAGESEVER

    2009-06-17

    Jun 17, 2009 ... characterized by a wide spectrum of clinical manifesta- tions, ranging from mild to ... The native IDS processing has been studied after .... the membrane was incubated overnight with a monoclonal antibody anti-IDS (1:250 in ...

  17. Rethinking Social Network Assessment for Students with Intellectual Disabilities (ID) in Postsecondary Education

    Science.gov (United States)

    Eisenman, Laura T.; Farley-Ripple, Elizabeth; Culnane, Mary; Freedman, Brian

    2013-01-01

    Social networks of persons with intellectual disabilities (ID) have been characterized as smaller and less diverse than those of typical peers. Advocates have focused on strengthening those social networks by expanding circles of social support, protection, and friendship. As young adults with ID experience increasing levels of community…

  18. Clarté des idées innées ?

    DEFF Research Database (Denmark)

    Schøsler, Jørn

    2013-01-01

    Der gives en analyse af begreberne 'evidens' og 'medfødte idéer' hos Descartes og Locke samt hos de franske oplysningsfilosoffer.......Der gives en analyse af begreberne 'evidens' og 'medfødte idéer' hos Descartes og Locke samt hos de franske oplysningsfilosoffer....

  19. 76 FR 9266 - Proposed Amendment of Class D and Class E Airspace; Idaho Falls, ID

    Science.gov (United States)

    2011-02-17

    ... Falls, ID AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend the Class D and Class E airspace areas at Idaho Falls, ID, by changing the name of the airport to Idaho Falls Regional Airport, and adjusting the...

  20. 76 FR 28306 - Amendment of Class D and Class E Airspace; Idaho Falls, ID

    Science.gov (United States)

    2011-05-17

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Idaho Falls, ID... existing Class D and Class E airspace at Idaho Falls, ID, by changing the name of the airport to Idaho Falls Regional Airport, and adjusting the geographic coordinates of the airport. This action also...

  1. 78 FR 25406 - Proposed Modification of Class E Airspace; Twin Falls, ID

    Science.gov (United States)

    2013-05-01

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Twin Falls, ID...: This action proposes to modify Class E airspace at Twin Falls Joslin Field-Magic Valley Regional Airport, Twin Falls, ID. Controlled airspace is necessary to accommodate aircraft using the...

  2. 78 FR 40382 - Modification of Class D and E Airspace; Twin Falls, ID

    Science.gov (United States)

    2013-07-05

    ... Federal Aviation Administration 14 CFR Part 71 Modification of Class D and E Airspace; Twin Falls, ID... Class E airspace at Twin Falls Joslin Field-Magic Valley Regional Airport, Twin Falls, ID, to... areas, as well as corrects the airport name to Twin Falls Joslin Field-Magic Valley Regional...

  3. 77 FR 56241 - Board Meeting; October 17, 2012; Idaho Falls, ID

    Science.gov (United States)

    2012-09-12

    ... REVIEW BOARD Board Meeting; October 17, 2012; Idaho Falls, ID The U.S. Nuclear Waste Technical Review... 1987, the U.S. Nuclear Waste Technical Review Board will hold a public meeting in Idaho Falls, Idaho... Board meeting will be held at the Hilton Garden Inn, 700 Lindsay Boulevard, Idaho Falls, ID 83402;...

  4. Long-range optical character recognition for product ID

    Science.gov (United States)

    Banta, Larry E.; Pertl, Franz A.; Rosenberry-Friend, Kimberly A.

    1998-10-01

    An automated product tag reading system based on CCD cameras and computer image processing has been developed by West Virginia University and demonstrated at the Weirton Steel Corporation. The system reads both a 50-mil barcode and a string of six numbers on a four-inch by six-inch tag fastened to the end of a steel slab. Feedback from the image is used to point and zoom the camera, making the system effective at ranges up to thirty feet, and in bright sunlight-situations where handheld barcode scanners are ineffective. A video camera is mounted on a pan/tilt head and connected to a personal computer through a frame grabber board. The whole system is mounted on a slab hauler--a huge wheeled machine for carrying 100 tons of steel slabs at a time. The slab hauler backs into position and presses `start' on a touchscreen operator interface. A wide-angle image is grabbed, and the computer analyzes the images to find product ID tags in scene. The camera is then zoomed and pointed one-by-one at the tags for closeup images. Geometric warping is done on the closeup images to correct for viewing angle distortion, and both the barcode and the alphanumeric code are read by the software and reported to the inventory management system via radio modern. This paper discusses the neural network-based system for reading the characters on the tag. The camera pointing system and barcode reader are discussed in a companion paper.

  5. ID-based authentication scheme combined with identity-based encryption with fingerprint hashing

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Current identity-based (ID) cryptosystem lacks the mechanisms of two-party authentication and user's private key distribution. Some ID-based signcryption schemes and ID-based authenticated key agreement protocols have been presented, but they cannot solve the problem completely. A novel ID-based authentication scheme based on ID-based encryption (IBE) and fingerprint hashing method is proposed to solve the difficulties in the IBE scheme, which includes message receiver authenticating the sender, the trusted authority (TA) authenticating the users and transmitting the private key to them. Furthermore, the scheme extends the application of fingerprint authentication from terminal to network and protects against fingerprint data fabrication. The fingerprint authentication method consists of two factors. This method combines a token key, for example, the USB key, with the user's fingerprint hash by mixing a pseudo-random number with the fingerprint feature. The security and experimental efficiency meet the requirements of practical applications.

  6. ID3算法在汽车售后服务中的应用%Application of ID3 Algorithm in Automotive After-sale Service

    Institute of Scientific and Technical Information of China (English)

    郭春丽; 李明东; 赵刚

    2011-01-01

    Decision tree algorithm has been successfully applied in much classification issue.ID3 algorithm is the representative algorithm.The application of algorithm has been given an instance study for the analysis of the customer features in the automotive after-sale service.Describing the principle and implementation of the ID3 algorithm and analyzing the features of the clients,also explaining concretely the approach of how to use ID3 to manage the clients in the automotive after-sale service.At the end,setting up the customer characteristics analysis model of automotive after-sale services.Through those strategies,the companies can realize the maximization of their total profits.%决策树算法被成功应用到很多分类问题上,其中ID3算法是其典型算法.文中就该算法在汽车售后服务企业客户特征分析中的应用做了实例研究.阐述了ID3算法的原理以及实现算法,分析了客户的特征.以一个具体的案例讲解了ID3算法在汽车售后服务企业中客户管理的具体应用流程.文中实现ID3算法作用于汽车售后客户的数据,得到一个客户特征分析模型,可以帮助汽车企业根据不同特征的客户采取不同的策略,从而获得较大利润.

  7. Vilnius eastern partnership summit: milestone in EU-Russia relations – not just for Ukraine

    Directory of Open Access Journals (Sweden)

    Havlik Peter

    2014-03-01

    Full Text Available The Vilnius Eastern Partnership Summit on 28-29th November 2013 represents a milestone in EU relations not just with respect to the six Eastern Partnership countries (EaP Armenia, Azerbaijan, Belarus, Georgia, Moldova and particularly Ukraine, but also with the EU’s ‘strategic partner’ Russia. The turbulence and numerous speculations regarding expectations about the signature of the EU-Ukraine Association Agreement (comprising a Deep and Comprehensive Free Trade Agreement - AA/DCFTA, as well as progress in initialling similar future agreements with Georgia and Moldova, have been escalating before the summit. The association agreementswould bring EaP signatory countries closer to the EU not really closer to EU membership, but closer to the application of various EU norms and standards (takeover of the ‘acquis communautaire’ and - significantly - out of the Russian orbit, for the beginning at least symbolically. The last minute postponement of the EU-Ukraine AA/DCFTA signature announced by Ukraine’s government just one week before the summit represents a serious setback for the EU. Though the EU has no ‘Plan B’ and was stunned after Ukraine’s announcement, life will continue after the summit and new initiatives will have to be started. What are the relevant issues and challenges and what is at stake? This note attempts to evaluate the consequences (economic and otherwise of alternate decisions following the Vilnius Eastern Partnership Summit, reviews some of the disputed arguments and discusses selected relevant economic issues.

  8. Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

    Directory of Open Access Journals (Sweden)

    Elke eBloem

    2015-01-01

    Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

  9. Id-1 promotes osteosarcoma cell growth and inhibits cell apoptosis via PI3K/AKT signaling pathway

    Energy Technology Data Exchange (ETDEWEB)

    Hao, Liang; Liao, Qi; Tang, Qiang [Department of Orthopaedic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 300006 (China); Deng, Huan [Department of Pathology, The Fourth Affiliated Hospital of Nanchang University, Nanchang 330006 (China); Chen, Lu, E-mail: chenlu0578@163.com [Department of Orthopaedic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 300006 (China)

    2016-02-12

    Accumulating evidence reveals that Id-1 is upregulated and functions as a potential tumor promoter in several human cancer types. However, the role of Id-1 in osteosarcoma (OS) is unknown. In present study, we found that Id-1 expression was elevated in OS tissues than adjacent normal bone tissues. More importantly, we demonstrated that overexpression of Id-1 is significantly correlated with tumor progression and poor survival in OS patients. Furthermore, increased expression of Id-1 was observed in OS cell lines and ectopic expression of Id-1 significantly enhanced in vitro cell proliferation and promoted in vivo tumor growth, whereas knockdown of Id-1 suppressed OS cells growth. Moreover, our experimental data revealed that Id-1 promotes cell proliferation by facilitating cell cycle progression and inhibits cell apoptosis. Mechanistically, the effects of Id-1 in OS cells is at least partly through activation of PI3K/Akt signaling pathway. Therefore, we identified a tumorigenic role of Id-1 in OS and suggested a potential therapeutic target for OS patients. - Highlights: • Id-1 expression is positively correlated in OS patients with poor prognosis. • Overexpression of Id-1 promotes OS cell growth in vitro and in vivo. • Id-1induces cell cycle progression and inhibits cell apoptosis. • PI3K/Akt signaling pathway contributed to the oncogenic effects of Id-1 in OS cells.

  10. Bio-fortification and shelf-life extension of idli batter using curry leaves (Murraya koenigii).

    Science.gov (United States)

    Chelliah, R; Ramakrishnan, S R; Premkumar, D; Antony, U

    2016-06-01

    Among several traditional foods of India, idli is one of the most popular and commonly consumed steamed products. A new method of adding Murraya koenigii (curry leaves) to idli batter as a vehicle for fortification and extension of shelf-life has been developed. Dried curry leaves powder was incorporated with other ingredients like rice and dehusked black gram in different proportions to optimize the most palatable formulation. Rate of fermentation and microbial changes in the batter; nutritional qualities, texture and sensory properties of the prepared product were assessed. Incorporation of curry leaves powder (5 %) in idli batter increased the shelf-life and also increased the flavour, texture and appearance of the idli. The calcium content of the prepared idli was 10 times more than that of the control idli, while dietary fiber content increased by 18.6 %. Anti-microbial activity of the curry leaves in idli batter extended the shelf-life from 2 to 5 days when stored at 30 °C.

  11. Smad3 mediates immediate early induction of Id1 by TGF-β

    Institute of Scientific and Technical Information of China (English)

    Yao-Yun Liang; F Charles Brunicardi; Xia Lin

    2009-01-01

    Id1 is a member of the inhibitor of diflferentiation(Id) protein family that regulates a wide range of cell functions.Previous studies have shown that expression of the ID1 gene is down-regulated by TGF-β in epithelial cells,whereas it is up-regulated by BMP in a variety of cell types.During our study of the biological function of TGF-β1,we found that ldl can be strongly up-regulated by TGF-β1 in the human mammary gland epithelial cell line MCF10A.Quanti-taftve real-time RT-PCR has revealed as high as 7.5-fold induction of ID1 mRNA by TGF-β1 in MCFlOA cells after 1 h of TGF-β1 stimulation,and this induction does not require de novo protein synthesis.Using Smad knockdown and knockout approaches.we have identiffed Smad3 as the responsible R-Smad for mediating transcriptional activation of the Id1 gene.Chromatin immunoprecipitation assay confirms that Smad3 and Smad4 bind to the upstream region of the Id1 gene.Our resuIts demonstrate that Smad3,but not Smad2,mediates TGF-β1-dependent early transcrip-tional induction of Id1.

  12. Id1 restrains p21 expression to control endothelial progenitor cell formation.

    Directory of Open Access Journals (Sweden)

    Alessia Ciarrocchi

    Full Text Available Loss of Id1 in the bone marrow (BM severely impairs tumor angiogenesis resulting in significant inhibition of tumor growth. This phenotype has been associated with the absence of circulating endothelial progenitor cells (EPCs in the peripheral blood of Id1 mutant mice. However, the manner in which Id1 loss in the BM controls EPC generation or mobilization is largely unknown. Using genetically modified mouse models we demonstrate here that the generation of EPCs in the BM depends on the ability of Id1 to restrain the expression of its target gene p21. Through a series of cellular and functional studies we show that the increased myeloid commitment of BM stem cells and the absence of EPCs in Id1 knockout mice are associated with elevated p21 expression. Genetic ablation of p21 rescues the EPC population in the Id1 null animals, re-establishing functional BM-derived angiogenesis and restoring normal tumor growth. These results demonstrate that the restraint of p21 expression by Id1 is one key element of its activity in facilitating the generation of EPCs in the BM and highlight the critical role these cells play in tumor angiogenesis.

  13. Engagement of membrane immunoglobulin enhances Id3 promoter activity in WEHI-231 B lymphoma cells

    Institute of Scientific and Technical Information of China (English)

    Xiao-jun LI; Kikumi HATA; Junichiro MIZUGUCHI

    2005-01-01

    Aim: We have recently shown that engagement of membrane immunoglobulin (mIg) induced upregulation of inhibitor of differentiation 3 (Id3) mRNA, resulting in growth arrest at G1 phase in WEHI-231 cells. In the present study, we examined whether engagement of mIg will affect promoter activity of the Id3 gene in WEHI231 cells. Methods: DNA fragments corresponding to the 5′-flanking region of mId3 gene were amplified by polymerase chain reaction (PCR) using genomic DNA as the template. Three DNA fragments upstream of the transcription start site (+ 1) of the mId3 gene were subcloned into the luciferase reporter vector PGVB2. The recombinant constructs were transiently transfected into WEHI-231 cells by an electroporation method. After incubation for 24 h, WEHI-231 cells were stimulated with 10 mg/L anti-IgM or irradiated CD40L-expressing NIH3T3 cells or control NIH3T3 cells for further 24 h, followed by assay for luciferase activity. Results: The luciferase analysis demonstrated that basal promoter activity of the Id3 gene was found in the region between -200 and +54. The Id3 promoter activity was increased 2-fold following stimulation with anti-IgM, but not CD40L, compared with medium alone. Conclusion: The mIg-mediated upregulation of Id3 expression is controlled, at least in part, through transcriptional regulation, as assessed by luciferase assay.

  14. An Improved ID3 Decision Tree Mining Algorithm%一种改进 ID3型决策树挖掘算法

    Institute of Scientific and Technical Information of China (English)

    潘大胜; 屈迟文

    2016-01-01

    By analyzing the problem of ID3 decision tree mining algorithm,the entropy calculation process is improved, and a kind of improved ID3 decision tree mining algorithm is built.Entropy calculation process of decision tree is rede-signed in order to obtain global optimal mining results.The mining experiments are carried out on the UCI data category 6 data set.Experimental results show that the improved mining algorithm is much better than the ID3 type decision tree mining algorithm in the compact degree and the accuracy of the decision tree construction.%分析经典 ID3型决策树挖掘算法中存在的问题,对其熵值计算过程进行改进,构建一种改进的 ID3型决策树挖掘算法。重新设计决策树构建中的熵值计算过程,以获得具有全局最优的挖掘结果,并针对 UCI 数据集中的6类数据集展开挖掘实验。结果表明:改进后的挖掘算法在决策树构建的简洁程度和挖掘精度上,都明显优于 ID3型决策树挖掘算法。

  15. Treatment planning: A key milestone to prevent treatment dropout in adolescents with borderline personality disorder.

    Science.gov (United States)

    Desrosiers, Lyne; Saint-Jean, Micheline; Breton, Jean-Jacques

    2015-06-01

    The aim of this study was to gain a broader appreciation of processes involved in treatment dropout in adolescents with borderline personality disorder (BPD). A constructivist grounded theory was chosen using a multiple-case research design with three embedded levels of analysis (adolescent, parent, and care setting). Theoretical sampling and the different stages of analysis specific to grounded theory were performed according to the iterative process of constant comparative analysis. Twelve cases were examined (nine dropouts among adolescents with BPD and for the purpose of falsification, one dropout of suicidal adolescent without BPD and two completed treatments among adolescents with BPD). To document the cases, three groups of informants were recruited (adolescents, parents, and therapists involved in the treatment) and 34 interviews were conducted. Psychological characteristics, perception of mental illness and mental health care, and help-seeking context were the specific treatment dropout vulnerabilities identified in adolescents with BPD and in their parents. However, their disengagement became an issue only when care-setting response--including mitigation of accessibility problems, adaptation of services to needs of adolescents with BPD, preparation for treatment, and concern for clinicians' disposition to treat--was ill-suited to these treatment dropout vulnerabilities. Treatment planning proves to be a key milestone to properly engage adolescents with BPD and their parent. Systematic assessment of treatment dropout vulnerabilities before the intervention plan is laid out could foster better-suited responses of the care setting thus decreasing the incidence of treatment discontinuation in adolescents with BPD. Treatment dropout vulnerabilities specific to adolescents with BPD and their parents can be detected before the beginning of treatment. Premature treatment termination may be prevented if the care setting considers these vulnerabilities at treatment

  16. Improvement and analysis of ID3 algorithm in decision-making tree

    Science.gov (United States)

    Xie, Xiao-Lan; Long, Zhen; Liao, Wen-Qi

    2015-12-01

    For the cooperative system under development, it needs to use the spatial analysis and relative technology concerning data mining in order to carry out the detection of the subject conflict and redundancy, while the ID3 algorithm is an important data mining. Due to the traditional ID3 algorithm in the decision-making tree towards the log part is rather complicated, this paper obtained a new computational formula of information gain through the optimization of algorithm of the log part. During the experiment contrast and theoretical analysis, it is found that IID3 (Improved ID3 Algorithm) algorithm owns higher calculation efficiency and accuracy and thus worth popularizing.

  17. The paradox of IDs: an account of an ethnographic experience in the US

    Directory of Open Access Journals (Sweden)

    Mariza Peirano

    2008-01-01

    Full Text Available In the modern world, IDs are indispensable objects, without which we cannot prove that we are who we say we are. We need material substantiation that attests to the authenticity of our self-identification. This paper is an account of an ethnographic experience about IDs and identification processes in the US, based on the examination of two events in which Eliot Spitzer, the New York State governor from January 2007 to March 2008, was a central figure. A comparison with the Brazilian scenario is present throughout the paper, and it ends by focusing on the ID theft phenomenon.

  18. 62 FR 28104 - Union Pacific Railroad CompanyAbandonment Exemptionin Malheur County, OR and Owyhee County, ID...

    Science.gov (United States)

    1997-05-22

    ... and Owyhee County, ID (Homedale Branch) On May 2, 1997, Union Pacific Railroad Company (UP) filed with..., and Owyhee County, ID, and includes the non-agency stations of Napton, OR-- milepost 16.90;...

  19. The treatable intellectual disability APP www.treatable-id.org: a digital tool to enhance diagnosis & care for rare diseases

    National Research Council Canada - National Science Library

    van Karnebeek, Clara D M; Houben, Roderick F A; Lafek, Mirafe; Giannasi, Wynona; Stockler, Sylvia

    2012-01-01

    .... Freely available as a WebAPP via http://www.treatable-id.org and end 2012 via the APP store, this diagnostic tool is designed for all specialists evaluating children with global delay / ID and laboratory scientists...

  20. The association of 2-year-old training milestones with career length and racing success in a sample of Thoroughbred horses in New Zealand.

    Science.gov (United States)

    Tanner, J C; Rogers, C W; Firth, E C

    2013-01-01

    There is increasing evidence that exercise early in life has a positive effect on musculoskeletal health. At present, there is little whole population research investigating the effect of racing as 2-year-olds on future racing career. To investigate the association between attaining training milestones as 2-year-olds with length of career and racing success in Thoroughbred horses in New Zealand. Retrospective data were obtained of the 2001/02-born Thoroughbred foal crop. The 3 training milestones were: registered with a trainer, trialled and raced. The association of the training milestones with career length was measured using the outcomes: number of race starts and number of years raced, in a Cox regression model. Logistic regression models analysed the association of the training milestones with the outcomes: won or placed in a race. Linear regression was performed to assess the association of training milestones with total career earnings. Of 4683 horses in the population; 3152 horses were registered with a trainer, 2661 horses trialled and 2109 horses raced. Horses that raced as 2-year-olds had significantly (Prace starts than those first raced as 3-year-olds or older, this was also true when the 2-year-old year data were omitted. Horses that raced as 2-year-olds had significantly (Pracing. Horses registered with a trainer, trialled or raced as 2-year-olds were more likely to have won or been placed in a race than those that achieved the milestones as 3-year-olds or older. Horses that first trialled and raced as 2-year-olds had greater total earnings than those that first trialled or raced at a later age. Two-year-old training milestones had a strong association with positive racing career outcomes. Horses in training or racing as 2-year-olds may have better musculoskeletal health throughout life than horses that are first in training or racing at a later age. © 2012 EVJ Ltd.

  1. A Hierarchical Linear Model with Factor Analysis Structure at Level 2

    Science.gov (United States)

    Miyazaki, Yasuo; Frank, Kenneth A.

    2006-01-01

    In this article the authors develop a model that employs a factor analysis structure at Level 2 of a two-level hierarchical linear model (HLM). The model (HLM2F) imposes a structure on a deficient rank Level 2 covariance matrix [tau], and facilitates estimation of a relatively large [tau] matrix. Maximum likelihood estimators are derived via the…

  2. Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    Science.gov (United States)

    Desprez, Pierre-Yves; Campisi, Judith

    2014-08-19

    A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

  3. Toward operation of series IDs at BL43LXU of SPring-8

    Energy Technology Data Exchange (ETDEWEB)

    Baron, A. Q. R.; Tanaka, T.; Soutome, K.; Takao, M.; Nakamura, T.; Kobayashi, K.; Fujita, T.; Takahashi, S.; Aoyagi, H.; Shimosaki, Y.; Seike, T.; Uchiyama, H.; Ishikawa, D.; Chuang, T.-H.; Kimura, H.; Tanaka, H.; Kitamura, H.; Ishikawa, T. [SPring-8, 1-1-1 Kouto, Sayo, Hyogo, 679 (Japan)

    2016-07-27

    This paper discusses two issues relating to using 3 small gap insertion devices in series at BL43LXU of SPring-8 to make a uniquely powerful source in the 15-26 keV region of the x-ray spectrum. The issues discussed are (1) damage to the covers of the downstream IDs by radiation from the upstream IDs and (2) proper steering of the electron beam to get the best photon beam properties. After tests in several configurations, including one where an ID was run without an impedance-reducing cover, the damage issue was solved by installing a distributed absorber in the most downstream ID. The steering issues were mostly resolved by the introduction of appropriate corrector magnets and feedback. The paper is written from the viewpoint of an interested beamline scientist impressed with the cooperation of different groups to make a source for new science possible.

  4. 76 FR 16367 - Implementation of the Truth in Caller ID Act of 2009

    Science.gov (United States)

    2011-03-23

    ...IP service,'' and defining ``Caller identification service'' to mean ``any service or device designed... identification information in technologies that are successor or replacement technologies to telecommunications... from causing any caller identification service to knowingly transmit misleading or inaccurate caller ID...

  5. ID migraine questionnaire in temporomandibular disorders with craniofacial pain: a study by using a multidisciplinary approach.

    Science.gov (United States)

    Di Paolo, Carlo; Di Nunno, Anna; Vanacore, Nicola; Bruti, Gianluca

    2009-08-01

    To evaluate the prevalence of migraine and related disability and the role of ID migraine questionnaire as a screening tool in patients with temporomandibular disorders (TMDs) and craniofacial pain (CFP). TMDs patients with CFP underwent stomatognathic (RDC/TMD criteria) and neurological visits (IHS criteria, 2004). ID migraine questionnaire and MIgraine Disability Assessment Scale (MIDAS) were also administered. Out of 45 patients, 69% met diagnosis of migraine plus chronic tension-type headache (CTTH); 9% presented CTTH and 20% were migraineurs. Out of 39 migraineurs who completed MIDAS, 56% presented the highest disability grade. Out of 37 patients who completed ID migraine questionnaire, 32 resulted affected by probable migraine with a diagnostic sensibility and specificity of 94% and 100%, respectively. Our findings showed a clinical association between TMDs and migraine. We support a clinical role of ID migraine and MIDAS in TMDs patients with CFP and we underline the importance of a multidisciplinary evaluation in this group of migraineurs.

  6. 80 FR 9279 - Deer Flat National Wildlife Refuge, Canyon, Payette, Owyhee, and Washington Counties, ID, and...

    Science.gov (United States)

    2015-02-20

    ...-2013-N279; 1265-0000-10137-S3] Deer Flat National Wildlife Refuge, Canyon, Payette, Owyhee, and..., 1010 Dearborn St, Caldwell, ID 83605. [ssquf] Homedale Public Library, 125 W Owyhee Ave, Homedale,...

  7. 76 FR 78940 - Minidoka National Wildlife Refuge, Blaine, Cassia, Minidoka, and Power Counties, ID...

    Science.gov (United States)

    2011-12-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service Minidoka National Wildlife Refuge, Blaine, Cassia, Minidoka, and Power Counties, ID; Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and...

  8. 78 FR 773 - Hartford Financial Services Group, Inc., Commercial/Actuarial/Information Delivery Services (IDS...

    Science.gov (United States)

    2013-01-04

    ... Employment and Training Administration Hartford Financial Services Group, Inc., Commercial/Actuarial/ Information Delivery Services (IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Affirmative... workers of Hartford Financial Services Group, Inc., Commercial/ Actuarial/Information Delivery...

  9. Infant-directed speech (IDS) vowel clarity and child language outcomes.

    Science.gov (United States)

    Hartman, Kelly M; Ratner, Nan Bernstein; Newman, Rochelle S

    2017-09-01

    There have been many studies examining the differences between infant-directed speech (IDS) and adult-directed speech (ADS). However, investigations asking whether mothers clarify vowel articulation in IDS have reached equivocal findings. Moreover, it is unclear whether maternal speech clarification has any effect on a child's developing language skills. This study examined vowel clarification in mothers' IDS at 0;10-11, 1;6, and 2;0, as compared to their vowel production in ADS. Relationships between vowel space, vowel duration, and vowel variability and child language outcomes at two years were also explored. Results show that vowel space and vowel duration tended to be greater in IDS than in ADS, and that one measure of vowel clarity, a mother's vowel space at 1;6, was significantly related to receptive as well as expressive child language outcomes at two years of age.

  10. The Evolution of IDS Solutions in Wireless Ad-Hoc Networks To Wireless Mesh Networks

    Directory of Open Access Journals (Sweden)

    Novarun Deb

    2011-12-01

    Full Text Available The domain of wireless networks is inherently vulnerable to attacks due to the unreliable wireless medium. Such networks can be secured from intrusions using either prevention or detection schemes. This paper focuses its study on intrusion detection rather than prevention of attacks. As attackers keep onimprovising too, an active prevention method alone cannot provide total security to the system. Here in lies the importance of intrusion detection systems (IDS that are solely designed to detect intrusions in real time. Wireless networks are broadly classified into Wireless Ad-hoc Networks (WAHNs, Mobile Adhoc Networks (MANETs, Wireless Sensor Networks (WSNs and the most recent Wireless Mesh Networks (WMNs. Several IDS solutions have been proposed for these networks. This paper is an extension to a survey of IDS solutions for MANETs and WMNs published earlier in the sense that the present survey offers a comparative insight of recent IDS solutions for all the sub domains of wireless networks.

  11. Family Impact in Intellectual Disability, Severe Mental Health Disorders and Mental Health Disorders in ID. A Comparison

    Science.gov (United States)

    Martorell, Almudena; Gutierrez-Recacha, Pedro; Irazabal, Marcia; Marsa, Ferran; Garcia, Mercedes

    2011-01-01

    Family impact (or family burden) is a concept born in the field of mental health that has successfully been exported to the ambit of intellectual disability (ID). However, differences in family impact associated with severe mental health disorders (schizophrenia), to ID or to mental health problems in ID should be expected. Seventy-two adults with…

  12. 6 CFR 37.5 - Validity periods and deadlines for REAL ID driver's licenses and identification cards.

    Science.gov (United States)

    2010-01-01

    ... SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S LICENSES AND IDENTIFICATION CARDS General § 37.5 Validity periods and deadlines for REAL ID driver's licenses and identification cards. (a) Driver's... individuals born after December 1, 1964, unless such license or card is a REAL ID-compliant driver's...

  13. Improved D-IDS using the federated peer-to-peer architecture

    Institute of Scientific and Technical Information of China (English)

    Hoan Kyu Lee; In Joo Jang; Hyeong Seon Yoo

    2007-01-01

    A number of IDSs have been proposed for a networked or distributed environment. A modified D-IDS using federated peer-to-peer architecture, MCR (Multicast Reflector) and modified shaker protocol were proposed. The suggested scheme can be implemented easily and performs the information sharing between low-level IDS agents. As all users within a group monitor each other's, the common control server can perform detect intrusions with less cost and support the detection of the inside intruders.

  14. Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis

    OpenAIRE

    Shin, Dong-Hui; Park, Ji-Hye; Lee, Jeong-Yeon; Won, Hee-Young; Jang, Ki-Seok; MIN, KYUENG-WHAN; Jang, Si-Hyong; Woo, Jong-Kyu; Oh, Seung Hyun; Kong, Gu

    2015-01-01

    Inhibitor of differentiation/DNA binding (Id)1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) activities in transgenic mice. MaSC-enriched basal cell expansion and increased self-renewal and in vivo regenerative capacity of MaSCs are observed in th...

  15. ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy

    DEFF Research Database (Denmark)

    Rai, Taranjit Singh; Dhandapany, Perundurai Subramaniam; Ahluwalia, Tarun Veer Singh

    2008-01-01

    The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM).......The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM)....

  16. Protection against Mycobacterium leprae infection by the ID83/GLA-SE and ID93/GLA-SE vaccines developed for tuberculosis.

    Science.gov (United States)

    Duthie, Malcolm S; Coler, Rhea N; Laurance, John D; Sampaio, Lucas H; Oliveira, Regiane M; Sousa, Ana Lucia M; Stefani, Mariane M A; Maeda, Yumi; Matsuoka, Masanori; Makino, Masahiko; Reed, Steven G

    2014-09-01

    Despite the dramatic reduction in the number of leprosy cases worldwide in the 1990s, transmission of the causative agent, Mycobacterium leprae, is still occurring, and new cases continue to appear. New strategies are required in the pursuit of leprosy elimination. The cross-application of vaccines in development for tuberculosis may lead to tools applicable to elimination of leprosy. In this report, we demonstrate that the chimeric fusion proteins ID83 and ID93, developed as antigens for tuberculosis (TB) vaccine candidates, elicited gamma interferon (IFN-γ) responses from both TB and paucibacillary (PB) leprosy patients and from healthy household contacts of multibacillary (MB) patients (HHC) but not from nonexposed healthy controls. Immunization of mice with either protein formulated with a Toll-like receptor 4 ligand (TLR4L)-containing adjuvant (glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) stimulated antigen-specific IFN-γ secretion from pluripotent Th1 cells. When immunized mice were experimentally infected with M. leprae, both cellular infiltration into the local lymph node and bacterial growth at the site were reduced relative to those of unimmunized mice. Thus, the use of the Mycobacterium tuberculosis candidate vaccines ID83/GLA-SE and ID93/GLA-SE may confer cross-protection against M. leprae infection. Our data suggest these vaccines could potentially be used as an additional control measure for leprosy. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  17. Id2 controls specification of Lgr5(+) intestinal stem cell progenitors during gut development.

    Science.gov (United States)

    Nigmatullina, Lira; Norkin, Maxim; Dzama, Margarita M; Messner, Berith; Sayols, Sergi; Soshnikova, Natalia

    2017-04-03

    The adult intestinal stem cells (ISCs), their hierarchies, mechanisms of maintenance and differentiation have been extensively studied. However, when and how ISCs are established during embryogenesis remains unknown. We show here that the transcription regulator Id2 controls the specification of embryonic Lgr5(+) progenitors in the developing murine small intestine. Cell fate mapping analysis revealed that Lgr5(+) progenitors emerge at E13.5 in wild-type embryos and differ from the rest on the intestinal epithelium by a characteristic ISC signature. In the absence of Id2, the intestinal epithelium differentiates into Lgr5(+) cells already at E9.5. Furthermore, the size of the Lgr5(+) cell pool is significantly increased. We show that Id2 restricts the activity of the Wnt signalling pathway at early stages and prevents precocious differentiation of the embryonic intestinal epithelium. Id2-deficient embryonic epithelial cells cultured ex vivo strongly activate Wnt target genes as well as markers of neoplastic transformation and form fast growing undifferentiated spheroids. Furthermore, adult ISCs from Id2-deficient mice display a distinct transcriptional signature, supporting an essential role for Id2 in the correct specification of ISCs. © 2017 The Authors.

  18. System Virtualization and Efficient ID Transmission Method for RFID Tag Infrastructure Network

    Directory of Open Access Journals (Sweden)

    Shin-ichi Kuribayashi

    2010-11-01

    Full Text Available The use of RFID tag which identifies a thing and an object will be expanded with progress of ubiquitoussociety, and it is necessary to study how to construct RFID network system as a social infrastructure likethe Internet. First, this paper proposes the virtualization method of RFID tag network system to enablethe same physical RFID network system to be used by multiple different service systems. The systemvirtualization not only reduces the system cost but also can dramatically reduce the installation space ofphysical readers and the operation cost. It is proposed that all equipments in the RFID network systemexcept RFID tag could be shared with the conventional virtual technologies. Then, this paper proposesthe conditional tag ID processing and the efficient tag ID transmission method which can greatly reducethe processing time and processing load in RFID tag Infrastructure network The conditional tag IDprocessing allows that tag ID is valid only at a certain time zone of day or in a certain area. The efficienttag ID transmission method uses the virtual network address of the service center as a part of the ID of anRF tag, which allows the direct ID forwarding to the service center.

  19. Social Withdrawal Behaviour at One Year of Age Is Associated with Delays in Reaching Language Milestones in the EDEN Mother-Child Cohort Study.

    Directory of Open Access Journals (Sweden)

    Antoine Guedeney

    Full Text Available The aim of the study was to examine the relationship between social withdrawal behaviour at one year and motor and language milestones.One-year old children from the EDEN French population-based birth cohort study (Study on the pre- and postnatal determinants of the child's development and prospective health Birth Cohort Study were included. Social withdrawal at one year was assessed by trained midwives using the Alarm Distress BaBy (ADBB scale. Midwives concurrently examined infants' motor and language milestones. Parents reported on child's psychomotor and language milestones, during the interview with the midwife.After adjusting for potential confounding factors, social withdrawal behaviour was significantly associated with concurrent delays in motor and language milestones assessed by the midwife or the parents.Higher scores on social withdrawal behaviour as assessed with the ADBB were associated with delays in reaching language milestones, and to a lesser extent with lower motor ability scores. Taking the contribution of social withdrawal behaviour into account may help understand the unfolding of developmental difficulties in children.

  20. Social Withdrawal Behaviour at One Year of Age Is Associated with Delays in Reaching Language Milestones in the EDEN Mother-Child Cohort Study.

    Science.gov (United States)

    Guedeney, Antoine; Forhan, Anne; Larroque, Beatrice; de Agostini, Maria; Pingault, Jean-Baptiste; Heude, Barbara

    2016-01-01

    The aim of the study was to examine the relationship between social withdrawal behaviour at one year and motor and language milestones. One-year old children from the EDEN French population-based birth cohort study (Study on the pre- and postnatal determinants of the child's development and prospective health Birth Cohort Study) were included. Social withdrawal at one year was assessed by trained midwives using the Alarm Distress BaBy (ADBB) scale. Midwives concurrently examined infants' motor and language milestones. Parents reported on child's psychomotor and language milestones, during the interview with the midwife. After adjusting for potential confounding factors, social withdrawal behaviour was significantly associated with concurrent delays in motor and language milestones assessed by the midwife or the parents. Higher scores on social withdrawal behaviour as assessed with the ADBB were associated with delays in reaching language milestones, and to a lesser extent with lower motor ability scores. Taking the contribution of social withdrawal behaviour into account may help understand the unfolding of developmental difficulties in children.

  1. Iodine status and associations with feeding practices and psychomotor milestone development in six-month-old South African infants.

    Science.gov (United States)

    Osei, Jennifer; Baumgartner, Jeannine; Rothman, Marinel; Matsungo, Tonderayi M; Covic, Namukolo; Faber, Mieke; Smuts, Cornelius M

    2016-12-28

    Iodine is important for normal growth and psychomotor development. While infants below 6 months of age receive iodine from breast milk or fortified infant formula, the introduction of complementary foods poses a serious risk for deteriorating iodine status. This cross-sectional analysis assessed the iodine status of six-month-old South African infants and explored its associations with feeding practices and psychomotor milestone development. Iodine concentrations were measured in infant (n = 386) and maternal (n = 371) urine (urinary iodine concentration [UIC]), and in breast milk (n = 257 [breast milk iodine concentrations]). Feeding practices and psychomotor milestone development were assessed in all infants. The median (25th-75th percentile) UIC in infants was 345 (213-596) μg/L and was significantly lower in stunted (302 [195-504] μg/L) than non-stunted (366 [225-641] μg/L) infants. Only 6.7% of infants were deficient. Maternal UIC (128 [81-216] μg/L; rs  = 0.218, p psychomotor developmental scores were observed. Our results suggest that iodine intake in the studied six-month-old infants was adequate. Iodine in breast milk and commercial infant cereals potentially contributed to this adequate intake.

  2. MISR Level 2 FIRSTLOOK TOA/Cloud Stereo parameters V001

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 FIRSTLOOK TOA/Cloud Stereo Product. It contains the Stereoscopically Derived winds, heights and cloud mask along with associated data, produced...

  3. MISR Level 2 TOA/Cloud Height and Motion parameters V001

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 TOA/Cloud Product containing the Stereo Heights, Stereoscopically Derived Cloud Mask (SDCM) and Cloud Motion Vectors with associated data....

  4. MISR Level 2 FIRSTLOOK TOA/Cloud Classifier parameters V001

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 FIRSTLOOK TOA/Cloud Classifiers Product. It contains the Angular Signature Cloud Mask (ASCM), Cloud Classifiers, and Support Vector Machine...

  5. GPM, NOAA19, MHS Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  6. GPM, METOP-A, MHS Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  7. GPM, METOP-B, MHS Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  8. MISR Level 2 FIRSTLOOK TOA/Cloud Albedo parameters V001

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the Level 2 FIRSTLOOK TOA/Cloud Albedo Product. It contains local,restrictive, and expansive albedo, with associated data, produced using ancillary inputs...

  9. GPM, GCOM-W1, AMSR2 Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  10. GPM, F17, SSMI Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  11. GPM, F18, SSMI Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  12. GPM, F16, SSMI Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  13. GPM, GCOM-W1, AMSR2 Level 2A Radiometer Profiling VV03B

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  14. GPM, TRMM, TMI Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  15. GPM, NOAA18, MHS Level 2A Radiometer Profiling VV03A

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AGPROF (also known as, GPM GPROF (Level 2)) algorithm retrieves consistent precipitation and related science fields from the following GMI and partner passive...

  16. Revised management plan, milestone plan, cost plan, and manpower plan. Sixth and seventh monthly status reports, October 1-November 30, 1978

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1978-01-01

    The following are included: project background and discussion, technical progress reports for all subtasks, contract management summary report, milestone schedule and status report, milestone log, cost plans, cost management reports, manpower plans, and manpower management reports. The following appendices are included: selection of heat pumps simulation locations, economic computations, fuel costs, system studies, recommended methodology for calculating residential load models, potential performance of heat pumps, data required from cooling contractors, cooling locations, thermal outputs: cooling, recommended inputs for the 25 ton advanced cooling simulation study, meteorological data, and contract modification. (MHR)

  17. 基于生物特征的Auto ID技术——BioID%Automated Biometric Personal Identification and Verification--BioID

    Institute of Scientific and Technical Information of China (English)

    李雄军; 苏廷弼

    2002-01-01

    文章全面而系统地综述了基于生物特征的Auto ID-BioID.重点分析了该技术与系统中的特殊问题,包括BioID系统通用模型、所使用的生物特征的类型、识别技术与系统设计上的共性与差异、性能要求及信号传输和存储两个关键问题;比较了声音、掌形、签名、脸谱、指纹、视网膜和虹膜几种典型的BioID技术的特点、性能与应用现状;探讨了BioID技术发展的动向与前景.

  18. The mathematical model for ID-201 semiconductor single photon counter%ID-201单光子计数器计数模型研究

    Institute of Scientific and Technical Information of China (English)

    曹攀; 朱广浩; 金飚兵

    2016-01-01

    InGaAs半导体单光子探测器具备探测性能强,集成度高等优势,在光谱分析和量子通信等领域有广泛的应用.本文以ID Quantique公司出品的ID-201半导体单光子计数器为研究对象,结合计数器核心部件雪崩光电二极管的工作原理探究其计数光子时的内部过程,推导出每秒钟光子计数值和该计数器几个重要参数触发频率(trigger frequency),门脉冲宽度(gate width),门强制关闭时间(dead time),探测效率(detection efficiency)之间的数学表达式.推导过程着重分析了计数门脉冲的关闭效应对光子探测概率的影响.首先利用泊松分布求解光子计数值与探测效率(detection efficiency)之间的关系,然后将计数过程分成两大部分,分析计数结果与门强制关闭时间(dead time)之间关系.求解得表达式后,利用1550 nm激光器作为ID-201的输入光源,在各种不同实验条件下,对该表达式的正确性进行了检验.%The technology of photon counting has wide applications in physics and electrical engineering.Single photon detectors based on avalanche photodiodes are attractive,Considering their advantages including compact sizes,broad spectrum of responses,and high detection efficiencies.The semiconductor single photon detector normally works in the gated mode,where photons can only be detected when the gate is open.However,if any photon is detected by the photon counter during the gate,several gates after the detection will be forced to shut down so that no photon can be detected during this period.The timing duration that the gates are down is called the dead time.This article mainly focuses on the photon counting performance of the ID-201 semiconductor photon counter,which is produced by the ID Quantique company.The purpose is to derive a photon counting formula for ID-201 and verify it using experiments.Starting with a simple Poisson distribution,we first studied the relationship between the detection

  19. International vision requirements for driver licensing and disability pensions: using a milestone approach in characterization of progressive eye disease

    Directory of Open Access Journals (Sweden)

    Alain M Bron

    2010-11-01

    Full Text Available Alain M Bron1, Ananth C Viswanathan2, Ulrich Thelen3, Renato de Natale4, Antonio Ferreras5, Jens Gundgaard6, Gail Schwartz7, Patricia Buchholz81Department of Ophthalmology, University Hospital, Dijon, France; 2Glaucoma Research Unit, Moorfields Eye Hospital NHS Foundation Trust and Department of Genetics, University College of London Institute of Ophthalmology, London, UK; 3Private Practice, Munster, Germany; 4Ospedale Civile di Monselice, Monselice, Italy; 5Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; 6COWI, Kolding, Denmark; 7Wilmer Eye Institute, Johns Hopkins University, Glaucoma Consultants, Baltimore, MD, USA; 8Patricia Buchholz Consulting, Karlsruhe, GermanyObjective: Low vision that causes forfeiture of driver’s licenses and collection of disability pension benefits can lead to negative psychosocial and economic consequences. The purpose of this study was to review the requirements for holding a driver’s license and rules for obtaining a disability pension due to low vision. Results highlight the possibility of using a milestone approach to describe progressive eye disease.Methods: Government and research reports, websites, and journal articles were evaluated to review rules and requirements in Germany, Spain, Italy, France, the UK, and the US.Results: Visual acuity limits are present in all driver’s license regulations. In most countries, the visual acuity limit is 0.5. Visual field limits are included in some driver’s license regulations. In Europe, binocular visual field requirements typically follow the European Union standard of ≥120°. In the US, the visual field requirements are typically between 110° and 140°. Some countries distinguish between being partially sighted and blind in the definition of legal blindness, and in others there is only one limit.Conclusions: Loss of driving privileges could be used as a milestone to monitor progressive eye disease. Forfeiture could be standardized as a

  20. Risk Factors Assessment of the Difficult Intubation using Intubation Difficulty Scale (IDS).

    Science.gov (United States)

    K Nasa, Vaibhav; S Kamath, Shaila

    2014-07-01

    The major responsibility of anaesthesiologist is to maintain adequate gas exchange in his patients in all circumstances and this require that patency of upper airway is constantly maintained. Problems with upper airway management are among the most frequent causes of anaesthetic mishaps. Using intubation difficulty scale (IDS) we made an attempt to objectively assess the predictors of difficult intubation. We assessed classical bedside tests such as modified Mallampati test, Thyromental distance test and also neck extension test. We prospectively observed 400 patients undergoing general anaesthesia with endotracheal intubation, for each patient intubation difficulty score was recorded during intubation. Risk factors assessment of difficult intubation done using IDS. Risk factor assessed includes modified mallampati class III and IV, thyromental distance ≤ 6cm and neck extension intubation (IDS, 0 to 2), slightly difficult intubation (IDS, 3 to 4) and difficult intubation (IDS 5). Preoperative airway assessment was done by thyromental distance measurement, neck extension measurement and modified mallampati test. Data was analysed using Receiver operating characteristic curve (ROC) and area under curve (AUC) for each test computed. pintubation was 8% and there were no failure to intubate the trachea. The AUC were as follows: modified Mallampati test 0.473 (ppredictor of difficult intubation (IDS≥5) in comparison to Thyromental test and modified mallampati test.

  1. Dynamic Programming for Single Nucleotide Polymorphism ID Identification in Systematic Association Studies

    Directory of Open Access Journals (Sweden)

    Cheng-Hong Yang

    2009-04-01

    Full Text Available Single nucleotide polymorphisms (SNPs play an important role in personalized medicine. However, the SNP data reported in many association studies provide only the SNP nucleotide/amino acid position, without providing the SNP ID recorded in National Center for Biotechnology Information databases. A tool with the ability to provide SNP ID identification, with a user-friendly interface, is needed. In this paper, a dynamic programming algorithm was used to compare homologs when the processed input sequence is aligned with the SNP FASTA database. Our novel system provides a web-based tool that uses the National Center for Biotechnology Information dbSNP database, which provides SNP sequence identification and SNP FASTA formats. Freely selectable sequence formats for alignment can be used, including general sequence formats (ACGT, [dNTP1/dNTP2] or IUPAC formats and orientation with bidirectional sequence matching. In contrast to the National Center for Biotechnology Information SNP-BLAST, the proposed system always provides the correct targeted SNP ID (SNP hit, as well as nearby SNPs (flanking hits, arranged in their chromosomal order and contig positions. The system also solves problems inherent in SNP-BLAST, which cannot always provide the correct SNP ID for a given input sequence. Therefore, this system constitutes a novel application which uses dynamic programming to identify SNP IDs from the literature and keyed-in sequences for systematic association studies. It is freely available at http://bio.kuas.edu.tw/SNPosition/.

  2. Changes of osteosarcoma cell biological behavior afterId1 gene silencing by siRNA

    Institute of Scientific and Technical Information of China (English)

    De-Li Xu

    2016-01-01

    Objective:To study the changes of osteosarcoma cell biological behaviors proliferation, migration and invasion afterId1gene silencing by siRNA.Methods:Osteosarcoma HEK293 cell lines were cultured and transfected with Id1-siRNA and NC-siRNA respectively, cell proliferation, migration and invasion were detected after 24 h and 48 h of transfection, and the expression levels of proliferation-promoting genes, proliferation-inhibiting genes as well as migration and invasion-related genes in cells were detected after 48 h of transfection. Results:After 24 h and 48 h of transfection, cell OD value and the number of invasive cells of Id1-siRNA group were significantly lower than those of NC-siRNA group, and scratch area was significantly larger than that of NC-siRNA group; after 48 h of transfection, hnRNP A2, hnRNP B1, S100A6, RUNX2, Aurora-A, Grb2, Gab2 and Rap2a expression levels of Id1-siRNA group were significantly lower than those of NC-siRNA group, and p53, TAp73 and IGFBP5 were significantly higher than those of NC-siRNA group.Conclusions:Id1 gene silencing by siRNA can inhibit osteosarcoma cell proliferation, migration and invasion.

  3. Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

    Directory of Open Access Journals (Sweden)

    Sema Inanir

    2016-04-01

    Full Text Available Abstract Background Major depressive disorder (MDD is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE has an important role in renin-angiotensin system (RAS and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.

  4. ACE I/D gene polymorphism in diabetic nephropathy: Clinical implications

    Directory of Open Access Journals (Sweden)

    M. Kaleemullah Khan

    2011-01-01

    Full Text Available Diabetic nephropathy (DN is a major microvascular complication accounting for about 30% of End-Stage Renal Disease (ESRD cases. An insertion/deletion (I/D polymorphism of the gene encoding angiotensin-I converting enzyme (ACE is reported to be a candidate gene predisposing to diabetic nephropathy. Accordingly, we investigated the ACE I/D gene polymorphism in 52 Type 2 diabetes mellitus (T2DM cases suffering from nephropathy as assessed by 24 hrs urinary protein levels. 50 age and sex matched healthy subjects served as controls. ACE I/D genotyping was carried out by polymerase chain reaction (PCR amplification using allele specific primers. The frequencies of ACE DD, ID and II genotypes in the diabetic nephropathy patients were 38.5% , 50% and 11.5% and in the control subjects, 22%, 38% and 40% respectively. There was an increase of 16.5% in the frequency of DD genotype in the patients compared to controls. The frequency of D allele in the patients was 63% which was found to be statistically significant (p< 0.05, Odds ratio=2.6 compared to 41% in the controls. These results indicate that Type 2 diabetic patients with D allele (those with DD & ID genotypes have more than two fold risk of developing nephropathy. Clinical implications of ACE genotyping in planning for patient’s management have been discussed.

  5. Increasing the Efficiency of IDS Systems by Hardware Implementation of Packet Capturing

    Directory of Open Access Journals (Sweden)

    Zeinab Latifi

    2013-08-01

    Full Text Available Capturing is the first step in intrusion detection system (IDS. Having wire speed, omitting the OS from capturing process and no need for making a copy of packets from the system’s environment to the user’s environment are some of the system characteristics. If these requirements are not met, packet capture system is considered as the main bottleneck of IDS and the overall efficiency of this system will be influenced. Presence of all these three characteristics calls for utilization of hardware methods. In this paper, by using of FPGA, a line sniffing and load balancing system are designed in order to be applied in IDS systems. The main contribution of our work is the feasibility of attaching labels to the beginning part of each packet, aiming at quick easy access of other IDS modules to information of each packet and also reducing workload of these modules. Packet classification in the proposed system can be configured to 2, 3, and 5 tuple, which can also be applied in IDS detection module in addition to load balancing part of this system. Load balancing module uses Hash table and its Hash function has the least flows collisions. This system is implemented on a set of virtex 6 and 7 families and is able to capture packets 100% and perform the above mentioned processes by speed of 12 Gbit/s.

  6. UTOPIA LEVEL2接口时序分析及FPGA实现%The Timing Analysis and FPGA Implementation of Utopia Level2

    Institute of Scientific and Technical Information of China (English)

    谢永安; 万旺根

    2009-01-01

    本文详细分析了ADSL系统中ATM层和物理层之间的UTOPIA LEVEL2接口时序,采用FPGA实现了UTOPIA接口设计,应用在ADSL系统中,数据收发正确,工作稳定;该方案的实现对解决现有专门通信芯片的成本较高、功能固定和灵活性较差等缺点具有较大的实际意义和应用价值.

  7. Incorporating Level-2 PSA Feature of CONPAS into AIMS-PSA Software

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sang Hoon; Lim, Hogon; Ahn, Kwang Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    CONPAS (CONtainment Performance Analysis System) utilizes a methodology to treat containment phenomena in detail like APET but in simple way. In mid 2000's, KAERI has developed very fast cut set generator FTREX and PC's OS (Operating system) has changed into Windows 95. Thus, KAERI has developed new Level-1 PSA software, called AIMS-PSA (Advanced Information Management System for PSA) to replace KIRAP. Recently, KAERI has been developing an integrated PSA platform, called OCEANS (On-line Consolidator and Evaluator of All mode risk for Nuclear System), for the risk assessment of all power modes and all hazards. CONPAS for Level-2 PSA was developed in 1990's using the Visual Basic 6.0 compiler which is not supported any more. It needs to be updated for the integrated PSA software framework. This paper describes a study to incorporate the features of CONPAS into AIMS-PSA. The basic idea is to follow the approach of CONPAS, but in the integrated way. Various approaches for Level-2 PSA have been used since WASH-1400. APET approach of NUREG-1150 study would be most comprehensive and complex methodology for containment event tree analysis. CONPAS is the Level-2 PSA software to utilize an approach to treat containment phenomena in detail like APET but in simple way. But, new Level-2 PSA software is required to develop more integrated PSA framework. A modified approach of CONPAS is developed and incorporated in AIMS-PSA software that can handle Level-1 and Level-2 PSA in the integrated way (from the viewpoint of event tree and fault tree). AIMS-PSA combines whole Level-2 PSA model to produce a One Top fault tree and to generate cut sets in the same way as Level-1 PSA. Quantification results of Level-2 PSA such as frequency for each STC can be calculated from the minimal cut sets.

  8. FHL2 Antagonizes Id1-Promoted Proliferation and Invasive Capacity of Human MCF-7 Breast Cancer Cells

    Institute of Scientific and Technical Information of China (English)

    Wei-dong Han; Zhi-qiang Wu; Ya-li Zhao; Yi-ling Si; Ming-zhou Guo; Xiao-bing Fu

    2010-01-01

    Objective:FHL2 was previously identified to be a novel interacting factor of Id family proteins.The aim of this study was to investigate,the effects of FHL2 on Id1-mediated transcriptional regulation activity and its oncogenic activity in human breast cancer cells.Methods:Cell transfection was performed by Superfect reagent.Id1 stably overexpressed MCF-7 cells was cloned by G418 screening.The protein level of Id1 was detected by western blot analysis.Dual relative luciferase assays were used to measure the effect of E47-mediated transcriptional activity in MCF-7 human breast cancer cells.MTT assay was used to measure cell proliferation.Transwell assay was used to measure the invasive capacity of MCF-7 cancer cells.Results:The basic helix-loop-helix(bHLH)factor E47-mediated transcription activity was markedly repressed by Id1 in MCF-7 cells.This Id1-mediated repression was effectively antagonized by FHL2 transduction.Overexpression of Id1 markedly promoted the proliferation rate and invasive capacity of MCF-7 cells; however,these effects induced by Id1 were significantly suppressed by overexpression of FHL2 in cells.Conclusion:FHL2 can inhibit the proliferation and invasiveness of human breast cancer cells by repressing the functional activity of Id1.These findings provide the basis for further investigating the functional roles of FHL2-Id1 signaling in the carcinogenesis and development of human breast cancer.

  9. Analysis of data mining classification by comparison of C4.5 and ID algorithms

    Science.gov (United States)

    Sudrajat, R.; Irianingsih, I.; Krisnawan, D.

    2017-01-01

    The rapid development of information technology, triggered by the intensive use of information technology. For example, data mining widely used in investment. Many techniques that can be used assisting in investment, the method that used for classification is decision tree. Decision tree has a variety of algorithms, such as C4.5 and ID3. Both algorithms can generate different models for similar data sets and different accuracy. C4.5 and ID3 algorithms with discrete data provide accuracy are 87.16% and 99.83% and C4.5 algorithm with numerical data is 89.69%. C4.5 and ID3 algorithms with discrete data provides 520 and 598 customers and C4.5 algorithm with numerical data is 546 customers. From the analysis of the both algorithm it can classified quite well because error rate less than 15%.

  10. ID-based deniable ring authentication with constant-size signature

    Institute of Scientific and Technical Information of China (English)

    Lingling WANG; Guoyin ZHANG; Chunguang MA

    2008-01-01

    Deniable ring authentication allows a member of an ad-hoc sunset of participants to authenticate a message without revealing which member has issued the signature, and the verifier cannot transfer the signature to any third party. It is an important cryptographic primitive for privacy and anonymous communication. Unfortunately, the size of the signature of the proposed deniable ring authentication is dependent on the size of the ring. It is inefficient especially when the size of the ring is large. In this paper, we propose an ID-based version of deniable ring authentication. We present a generic construction which uses dynamic accumu-lators to construct ID-based deniable ring authentication with constant-size signature. We also give an ID-based deni-able ring authentication based on bilinear pairings, which is proved to be secure in the random oracle model.

  11. Formalization and Parsing of Typed Unification-Based ID/LP Grammars

    CERN Document Server

    Morawietz, F

    1999-01-01

    This paper defines unification based ID/LP grammars based on typed feature structures as nonterminals and proposes a variant of Earley's algorithm to decide whether a given input sentence is a member of the language generated by a particular typed unification ID/LP grammar. A solution to the problem of the nonlocal flow of information in unification ID/LP grammars as discussed in Seiffert (1991) is incorporated into the algorithm. At the same time, it tries to connect this technical work with linguistics by presenting an example of the problem resulting from HPSG approaches to linguistics (Hinrichs and Nakasawa 1994, Richter and Sailer 1995) and with computational linguistics by drawing connections from this approach to systems implementing HPSG, especially the TROLL system, Gerdemann et al. (forthcoming).

  12. Comportamiento del inversionista a diferentes niveles de inversión en I+D

    Directory of Open Access Journals (Sweden)

    Ángel Samaniego Alcántar

    2012-01-01

    Full Text Available Este trabajo analiza, usando una metodología alterna a la existente en la literatura del tema, la existencia de rendimientos anormales en el corto plazo ocasionados por cambios en la intensidad de la inversión en proyectos de investigación y desarrollo, I+D (R&D intensity. Se observa que los inversionistas obtienen rendimientos anormales en portafolios de empresas que incrementan entre cinco a diez unidades la intensidad del I+D (o cuando este incremento es mayor a 25 unidades. Sin embargo, ante decrementos en la intensidad del I+D no se observan desviaciones en los rendimientos esperados; asimismo, el rendimiento anormal es mayor en empresas de alta tecnología. El periodo analizado es 2001-2006 en los mercados AMEX, NYSE y NASDAQ.

  13. Health-related quality of life, developmental milestones, and self-esteem in young adults with bleeding disorders.

    Science.gov (United States)

    Limperg, P F; Haverman, L; Maurice-Stam, H; Coppens, M; Valk, C; Kruip, M J H A; Eikenboom, J; Peters, M; Grootenhuis, M A

    2017-09-12

    The treatment of bleeding disorders improved in the last decades. However, the effect of growing up with bleeding disorders on developmental, emotional, and social aspects is understudied. Therefore, this study assesses HRQOL, developmental milestones, and self-esteem in Dutch young adults (YA) with bleeding disorders compared to peers. Ninety-five YA (18-30 years) with bleeding disorders (78 men; mean 24.7 years, SD 3.5) and 17 women (mean 25.1 years, SD 3.8) participated and completed the Pediatric Quality of Life Inventory Young Adult version, the Course of Life Questionnaire, and the Rosenberg Self-Esteem Scale. Differences between patients with bleeding disorders and their peers, and between hemophilia severity groups, were tested using Mann-Whitney U tests. YA men with bleeding disorders report a slightly lower HRQOL on the total scale, physical functioning, and school/work functioning in comparison to healthy peers (small effect sizes). YA men with severe hemophilia report more problems on the physical functioning scale than non-severe hemophilia. YA men with bleeding disorders achieved more psychosexual developmental milestones than peers, but show a delay in 'paid jobs, during middle and/or high school.' A somewhat lower self-esteem was found in YA men with bleeding disorders in comparison to peers (small effect size). For YA women with bleeding disorders, no differences were found on any of the outcomes in comparison to peers. This study demonstrates some impairments in HRQOL and self-esteem in YA men with bleeding disorders. By monitoring HRQOL, problems can be identified early, especially with regard to their physical and professional/school functioning.

  14. Challenge problem and milestones for : Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC).

    Energy Technology Data Exchange (ETDEWEB)

    Freeze, Geoffrey A.; Wang, Yifeng; Howard, Robert; McNeish, Jerry A.; Schultz, Peter Andrew; Arguello, Jose Guadalupe, Jr.

    2010-09-01

    This report describes the specification of a challenge problem and associated challenge milestones for the Waste Integrated Performance and Safety Codes (IPSC) supporting the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The NEAMS challenge problems are designed to demonstrate proof of concept and progress towards IPSC goals. The goal of the Waste IPSC is to develop an integrated suite of modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with robust verification, validation, and software quality requirements. To demonstrate proof of concept and progress towards these goals and requirements, a Waste IPSC challenge problem is specified that includes coupled thermal-hydrologic-chemical-mechanical (THCM) processes that describe (1) the degradation of a borosilicate glass waste form and the corresponding mobilization of radionuclides (i.e., the processes that produce the radionuclide source term), (2) the associated near-field physical and chemical environment for waste emplacement within a salt formation, and (3) radionuclide transport in the near field (i.e., through the engineered components - waste form, waste package, and backfill - and the immediately adjacent salt). The initial details of a set of challenge milestones that collectively comprise the full challenge problem are also specified.

  15. ACE I/D genotype, adiposity, and blood pressure in children

    Directory of Open Access Journals (Sweden)

    Rothschild Max

    2009-03-01

    Full Text Available Abstract Background Angiotensin converting enzyme (ACE is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of potential candidate genes, and specifically ACE I/D, on adiposity and BP phenotypes in childhood. Such studies may prove insightful for the development of the obesity-hypertension phenotype early in life. The purpose of this study was to examine differences in body fatness and resting blood pressure (BP by ACE I/D genotype, and determine if the association between adiposity and BP varies by ACE I/D genotype in children. Methods 152 children (75 girls, 77 boys were assessed for body composition (% body fat using dual energy x-ray absorbtiometry and resting BP according to American Heart Association recommendations. Buccal cell samples were genotyped using newly developed PCR-RFLP tests for two SNPs (rs4341 and rs4343 in complete linkage disequilibrium with the ACE I/D polymorphism. Partial correlations were computed to assess the ociations between % body fat and BP in the total sample and by genotype. ANCOVA was used to examine differences in resting BP by ACE I/D genotype and fatness groups. Results Approximately 39% of youth were overfat based on % body fat (>30% fat in girls, 25% fat in boys. Body mass, body mass index, and fat-free mass were significantly higher in the ACE D-carriers compared to the II group (p Conclusion ACE D-carriers are heavier than ACE II children; however, BP did not differ by ACE I/D genotype but was adversely influenced in the overfat D-carriers. Further studies are warranted to investigate the genetics of fatness and BP phenotypes in children.

  16. Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-β2 in Human TM Cells

    Science.gov (United States)

    Mody, Avani A.; Wordinger, Robert J.; Clark, Abbot F.

    2017-01-01

    Purpose Increased expression of TGF-β2 in primary open-angle glaucoma (POAG) aqueous humor (AH) and trabecular meshwork (TM) causes deposition of extracellular matrix (ECM) in the TM and elevated IOP. Bone morphogenetic proteins (BMPs) regulate TGF-β2–induced ECM production. The underlying mechanism for BMP4 inhibition of TGF-β2–induced fibrosis remains undetermined. Bone morphogenic protein 4 induces inhibitor of DNA binding proteins (ID1, ID3), which suppress transcription factor activities to regulate gene expression. Our study will determine whether ID1and ID3 proteins are downstream targets of BMP4, which attenuates TGF-β2 induction of ECM proteins in TM cells. Methods Primary human TM cells were treated with BMP4, and ID1 and ID3 mRNA, and protein expression was determined by quantitative PCR (Q-PCR) and Western immunoblotting. Intracellular ID1 and ID3 protein localization was studied by immunocytochemistry. Transformed human TM cells (GTM3 cells) were transfected with ID1 or ID3 expression vectors to determine their potential inhibitory effects on TGF-β2–induced fibronectin and plasminogen activator inhibitor-I (PAI-1) protein expression. Results Basal expression of ID1-3 was detected in primary human TM cells. Bone morphogenic protein 4 significantly induced early expression of ID1 and ID3 mRNA (P < 0.05) and protein in primary TM cells, and a BMP receptor inhibitor blocked this induction. Overexpression of ID1 and ID3 significantly inhibited TGF-β2–induced expression of fibronectin and PAI-1 in TM cells (P < 0.01). Conclusions Bone morphogenic protein 4 induced ID1 and ID3 expression suppresses TGF-β2 profibrotic activity in human TM cells. In the future, targeting specific regulators may control the TGF-β2 profibrotic effects on the TM, leading to disease modifying IOP lowering therapies. PMID:28159972

  17. Suurnimed jäid müümata / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    9. mai Christie' oksjonist, müümata jäänud Picasso, Degas', Cezanne'i tööd. 8. mai Sotheby oksjonist, kus edukalt müüdi töid S. J. Seegeri kogust, 3,85 miljoni dollari eest M. Beckmanni "Perseuse viimane katsumus". Sotheby kaasaegse kunsti oksjonil New Yorgis müüdi 5,6 miljoni dollari eest J. Koonsi skulptuur M. Jacksonist. Müümata jäid A. Warholi "Viis supipurki", A. Calderi 3 skulptuuri

  18. Pairing-Free ID-Based Key-Insulated Signature Scheme

    Institute of Scientific and Technical Information of China (English)

    Guo-Bin Zhu; Hu Xiong; Zhi-Guang Qin

    2015-01-01

    Abstract⎯Without the assumption that the private keys are kept secure perfectly, cryptographic primitives cannot be deployed in the insecure environments where the key leakage is inevitable. In order to reduce the damage caused by the key exposure in the identity-based (ID-based) signature scenarios efficiently, we propose an ID-based key-insulated signature scheme in this paper, which eliminates the expensive bilinear pairing operations. Compared with the previous work, our scheme minimizes the computation cost without any extra cost. Under the discrete logarithm (DL) assumption, a security proof of our scheme in the random oracle model has also been given.

  19. Tamaño, restricciones financieras e inversión en i+d

    OpenAIRE

    María Ángeles Marra Domínguez

    2007-01-01

    Este trabajo analiza empíricamente los efectos de restricciones de liquidez en la inversión en actividades de I+D de una muestra de empresas manufactureras españolas clasificada según su tamaño durante el periodo 1991-1999. Las estimaciones confirman que la inversión en I+D emprendida por las empresas de menor tamaño presenta una mayor sensibilidad al cash flow y una relación negativa fuerte con la tasa de endeudamiento, lo que sugiere la posible presencia de restricciones financieras. Por el...

  20. MA- IDS: A Distributed Intrusion Detection System Based on Data Mining

    Institute of Scientific and Technical Information of China (English)

    SUN Jian-hua; JIN Hai; CHEN Hao; HAN Zong-fen

    2005-01-01

    Aiming at the shortcomings in intrusion detection systems (IDSs) used in commercial and research fields,we propose the MA-IDS system, a distributed intrusion detection system based on data mining. In this model, misuse intrusion detection system (MIDS) and anomaly intrusion detection system (AIDS) are combined. Data mining is applied to raise detection performance, and distributed mechanism is employed to increase the scalability and efficiency. Host- and network-based mining algorithms employ an improved Bayesian decision theorem that suits for real security environment to minimize the risks incurred by false decisions. We describe the overall architecture of the MA-IDS system, and discuss specific design and implementation issue.

  1. Evaluation of S. aureus ID, a New Chromogenic Agar Medium for Detection of Staphylococcus aureus

    OpenAIRE

    Perry, John D.; Rennison, Claire; Butterworth, Lynne A.; Hopley, Andrew L. J.; Gould, F. Kate

    2003-01-01

    S. aureus ID (bioMérieux, La Balme Les Grottes, France) is a new chromogenic agar medium designed to enable the isolation of staphylococci and the specific identification of Staphylococcus aureus. S. aureus produces green colonies on this medium due to production of α-glucosidase. To evaluate this medium, a total of 350 wound swabs were cultured onto S. aureus ID, CHROMagar Staph. aureus, and conventional media routinely used in our laboratory. After 18 to 20 h of incubation, 96.8% of strains...

  2. Projectc conception for city logistics with utilization of IDS element applicated to the Nitra city

    Directory of Open Access Journals (Sweden)

    Michal Balog

    2010-02-01

    Full Text Available Nowadays traffic situation in the town-residential area is characterized by growing requirement for quality and quantityof transfer performance and services that result in congestion increasing in the some towns. Currently the similar problem has Nitracity, where it is necessary to solve this situation immediately. One of the possibilities of increasing traffic fluency is to extend roads, butin case of Nitra that possibility is irrelevant because of non-available space. Other possibility is an utilization of IDS elements(Intelligent Transport System. The contribution presents the conception of transportation in the town, founded on creation of trafficcircles with subsequent IDS elements application.

  3. Comportamiento del inversionista a diferentes niveles de inversión en I+D

    OpenAIRE

    Ángel Samaniego Alcántar; Carlos Omar Trejo Pech; Samuel Mongrut Montalván; Darcy Fuenzalida O´Shee

    2012-01-01

    Este trabajo analiza, usando una metodología alterna a la existente en la literatura del tema, la existencia de rendimientos anormales en el corto plazo ocasionados por cambios en la intensidad de la inversión en proyectos de investigación y desarrollo, I+D (R D intensity). Se observa que los inversionistas obtienen rendimientos anormales en portafolios de empresas que incrementan entre cinco a diez unidades la intensidad del I+D (o cuando este incremento es mayor a 25 unidades). Sin embargo,...

  4. Investigation on AQ11, ID3 and the Principle of Discernibility Matrix

    Institute of Scientific and Technical Information of China (English)

    王珏; 崔佳; 赵凯

    2001-01-01

    The principle of discernibility matrix serves as a tool to discuss and analyze two algorithms of traditional inductive machine learning, AQ11 and ID3. The results are: (1) AQ11 and its family can be completely specified by the principle of discernibility matrix; (2) ID3 can be partly, but not naturally, specified by the principle of discernibility matrix; and (3) The principle of discernibility matrix is employed to analyze Cendrowska sample set, and it shows the weaknesses of knowledge representation style of decision tree in theory.

  5. Gestión de la incertidumbre en los proyectos de I+D

    OpenAIRE

    García Muntión, Paula

    2014-01-01

    En el presente TFM se estudian diferentes metodologías y herramientas con el objeto de presentar una propuesta metodológica basada en el PMBOK que facilite la gestión de los Proyectos I+D. Para realizar esta propuesta y facilitar la implantación de una gestión de proyectos adecuada a las características de los proyectos de I+D será fundamental identificar cuáles son los principales bloqueadores y facilitadores que se encuentran. La propuesta metodológica deberá contemplar el tratamiento de...

  6. Exploration as a Mediator of the Relation between the Attainment of Motor Milestones and the Development of Spatial Cognition and Spatial Language

    Science.gov (United States)

    Oudgenoeg-Paz, Ora; Leseman, Paul P. M.; Volman, M. J. M.

    2015-01-01

    The embodied-cognition approach views cognition and language as grounded in daily sensorimotor child-environment interactions. Therefore, the attainment of motor milestones is expected to play a role in cognitive-linguistic development. Early attainment of unsupported sitting and independent walking indeed predict better spatial cognition and…

  7. Exploration as a Mediator of the Relation between the Attainment of Motor Milestones and the Development of Spatial Cognition and Spatial Language

    Science.gov (United States)

    Oudgenoeg-Paz, Ora; Leseman, Paul P. M.; Volman, M. J. M.

    2015-01-01

    The embodied-cognition approach views cognition and language as grounded in daily sensorimotor child-environment interactions. Therefore, the attainment of motor milestones is expected to play a role in cognitive-linguistic development. Early attainment of unsupported sitting and independent walking indeed predict better spatial cognition and…

  8. Methods for Analyzing the Attainment of Graduate School Milestones: A Case Study. GRE Board Professional Report No. 86-3P.

    Science.gov (United States)

    Zwick, Rebecca; Braun, Henry I.

    Using a data base compiled by the Graduate School of Northwestern University, a longitudinal study of the graduate school careers of 2,211 students in 14 programs was conducted. Among the most prominent findings was the increase in the enrollment of foreign students. The patterns of attainment of graduate school milestones, such as Ph. D.…

  9. Global grid for Big Bang research reaches milestone One major test remains as grid project prepares to go live next year

    CERN Multimedia

    Weiss, Todd R

    2006-01-01

    "A huge 100,000-PC grid-computing network being built to help research the origin of the universe passed the third of four major tests recently when it reached a data-transfer milestone, with up to 1GB/sec. of physics data sent over the global grid"(1.5 page)

  10. Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse

    Directory of Open Access Journals (Sweden)

    Yokota Yoshifumi

    2004-12-01

    Full Text Available Abstract Background During pregnancy, the mammary glands from Id2 mutant animals are deficient in lobulo-alveolar development. This failure of development is believed to be due to a proliferation defect. Methods We have asked whether functional Id2 expression is necessary for Wnt induced mammary hyperplasia, side branching, and cancer, by generating mice expressing a Wnt1 transgene in an Id2 mutant background. Results We show in this work that forced expression of Wnt1 in the mammary gland is capable of overcoming the block to proliferation caused by the absence of Id2. We also show that Wnt1 expression is able to cause mammary tumors in an Id2 mutant background. Conclusions We conclude that functional Id2 expression is not required for Wnt1 to induce mammary hyperplasia and mammary tumors.

  11. Combination of electron beam irradiation and thermal treatment to enhance the shelf-life of traditional Indian fermented food (Idli)

    Science.gov (United States)

    Mulmule, Manoj D.; Shimmy, Shankar M.; Bambole, Vaishali; Jamdar, Sahayog N.; Rawat, K. P.; Sarma, K. S. S.

    2017-02-01

    Idli, a steam-cooked breakfast food item consumed in India, is famous as a staple food for its spongy texture and unique fermented taste. Idli preparation is a time consuming process; although instant Idli pre-mixes as powder or batter are available in the market, they do not have the distinctive taste and aroma similar to the Idli prepared at home. Hence ready-to-eat (RTE) form of this food is in demand. Therefore, an attempt was made to prepare RTE Idli bearing similar taste as home-cooked Idli with an extended shelf-life of up to two months at an ambient temperature using Electron Beam Irradiation (EBI) at dosages 2.5 kGy, 5 kGy and 7.5 kGy and combination processing comprised of EBI dosage at 2.5 kGy and thermal treatment (80 °C for 20 min). The treated Idli's were microbiologically and sensorially evaluated at storage periods of zero day, 14 days, 30 days and 60 days. Idli's irradiated at 7.5 kGy and subjected to combination processing at 2.5 kGy and thermal treatment were shelf-stable for 60 days. 2.5 kGy and 5 kGy radiation dosages alone were not sufficient to preserve Idli samples for more than 14 days. Undesirable change in sensory properties of Idli was observed at an EBI dosage of 7.5 kGy. Sensory properties of combination processed Idli's were found to undergo minor change over the storage period. The present work suggests that lowest radiation dosage in combination with thermal treatment could be useful to achieve the extended shelf-life without considerably impairing the organoleptic quality of Ready-to-Eat Idli.

  12. Attitudes of Israeli Teachers and Paraprofessionals towards the New Definition of ID and Their Willingness to Cope with Special Education Law Changes

    Science.gov (United States)

    Lifshitz, Hefziba; Nissim, Shoshanna; Cohen, Sara

    2008-01-01

    Attitudes of teachers (N = 96) and paraprofessionals (N = 48) working with students with intellectual disability (ID) towards the new definition of ID (Luckasson et al., 1992, 2002), was examined. The main innovation of the new definition of ID is the cancellation of the four ID levels, suggesting an optimistic view, especially towards individuals…

  13. Impact on house staff evaluation scores when changing from a Dreyfus- to a Milestone-based evaluation model: one internal medicine residency program's findings

    Directory of Open Access Journals (Sweden)

    Karen A. Friedman

    2014-11-01

    Full Text Available Purpose: As graduate medical education (GME moves into the Next Accreditation System (NAS, programs must take a critical look at their current models of evaluation and assess how well they align with reporting outcomes. Our objective was to assess the impact on house staff evaluation scores when transitioning from a Dreyfus-based model of evaluation to a Milestone-based model of evaluation. Milestones are a key component of the NAS. Method: We analyzed all end of rotation evaluations of house staff completed by faculty for academic years 2010–2011 (pre-Dreyfus model and 2011–2012 (post-Milestone model in one large university-based internal medicine residency training program. Main measures included change in PGY-level average score; slope, range, and separation of average scores across all six Accreditation Council for Graduate Medical Education (ACGME competencies. Results: Transitioning from a Dreyfus-based model to a Milestone-based model resulted in a larger separation in the scores between our three post-graduate year classes, a steeper progression of scores in the PGY-1 class, a wider use of the 5-point scale on our global end of rotation evaluation form, and a downward shift in the PGY-1 scores and an upward shift in the PGY-3 scores. Conclusions: For faculty trained in both models of assessment, the Milestone-based model had greater discriminatory ability as evidenced by the larger separation in the scores for all the classes, in particular the PGY-1 class.

  14. 77 FR 59639 - Bear Lake National Wildlife Refuge, Bear Lake County, ID and Oxford Slough Waterfowl Production...

    Science.gov (United States)

    2012-09-28

    ... public, including opportunities for hunting, fishing, wildlife observation and photography, and... review at the following libraries: Bear Lake County Library, 138 North 6th Street, Montpelier, ID 83254...

  15. Level 2 Perspective Taking Entails Two Processes: Evidence from PRP Experiments

    Science.gov (United States)

    Janczyk, Markus

    2013-01-01

    In many situations people need to mentally adopt the (spatial) perspective of other persons, an ability that is referred to as "Level 2 perspective taking." Its underlying processes have been ascribed to mental self-rotation that can be dissociated from mental object-rotation. Recent findings suggest that perspective taking/self-rotation…

  16. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2, Teacher. Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The major goal of the Comprehensive Instructional Management System (CIMS) for mathematics is to provide classroom teachers in New York City with a well-structured, objective-based curriculum. This second part of the manual for Level 2 includes modules for 12 topics: numbers and numeration; addition of whole numbers; subtraction of whole numbers;…

  17. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System (CIMS) in Mathematics for Level 2, Part 1, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. The 85…

  18. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 2, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The activities in this mathematics workbook are designed to provide pupils with practice in mastering the performance objectives of Level 2, Part 2, in the Comprehensive Instructional Management System (CIMS) for New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. The 128…

  19. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1, Teacher, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The major goal of the Comprehensive Instructional Management System (CIMS) for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This first part of the manual for Level 2 includes varied numbers of modules for 12 topics: numbers and numeration; addition of whole numbers;…

  20. What's Going on in Your Professor's Head? Demonstrating the Id, Ego, and Superego

    Science.gov (United States)

    Segrist, Dan J.

    2009-01-01

    This article describes an in-class activity designed to demonstrate Freud's structural theory of the psyche, specifically the roles of the id, ego, and superego, as well as the interplay among them. Additionally, the activity visually illustrates Freud's ideas about the levels of consciousness associated with these 3 components. Pre-post quiz…

  1. Permutations with Kazhdan-Lusztig polynomial P_{id,w}(q) = 1 + q^h

    OpenAIRE

    Woo, Alexander; Billey, Sara; Weed, Jonathan

    2008-01-01

    Using resolutions of singularities introduced by Cortez and a method for calculating Kazhdan-Lusztig polynomials due to Polo, we prove the conjecture of Billey and Braden characterizing permutations w with Kazhdan-Lusztig polynomial P_{id,w}(q)=1+q^h for some h.

  2. 76 FR 36896 - Salmon-Challis National Forest, ID; Forestwide Invasive Plant Treatment Environmental Impact...

    Science.gov (United States)

    2011-06-23

    ... Forest Service Salmon-Challis National Forest, ID; Forestwide Invasive Plant Treatment Environmental... impact statement. SUMMARY: Invasive plants have been identified as a major threat to the biological diversity and ecological integrity within and outside the Salmon-Challis National Forest. Invasive plants...

  3. Accelerated fermentation of Idli batter using Eleusine coracana and Pennisetum glaucum.

    Science.gov (United States)

    Chelliah, Ramachandran; Ramakrishnan, Sudha Rani; Premkumar, Divya; Antony, Usha

    2017-08-01

    The present study focuses on reduction in fermentation time of idli batter and its enrichment with calcium and iron using finger millet and pearl millet. Fermentation time decreased from 12 to 6 h with addition of finger millet and to 8 h with pearl millet. Rate of fermentation, bulk density, viscosity, microbial changes and particle morphology were assessed in the batter; nutritional quality, sensory, phytochemicals and internal characteristics of idli were investigated. The color and texture characteristics of both batter and idli were evaluated. The pH and titratable acidity of control batter at 6 h was 5.32 and 0.27%, addition of finger and pearl millet changed to 4.32, 0.45% and 4.53, 0.45% at respective fermentation times (6 and 8 h). The viable yeast, lactic acid bacteria and total bacterial count (log CFU g(-1)) in the batters increased with time, reaching 1.26, 3.85, 4.56 (control); 2.32, 9.84, 9.58 (finger millet) and 1.76, 7.34, 7.74 (pearl millet) respectively at the end of 6 h of fermentation. Addition of finger millet and pearl millet flour (10% w/w) to the batter enhanced the dietary fiber by 28 and 23%, calcium by 113 and 56%, iron by 51 and 258% in the respective idlies when compared with the control.

  4. 76 FR 46721 - Salmon-Challis National Forest, ID; Upper North Fork HFRA Ecosystem Restoration Project...

    Science.gov (United States)

    2011-08-03

    ... this project area to improve the health of the ecosystem and reach the desired future condition. DATES...; ] DEPARTMENT OF AGRICULTURE Forest Service Salmon-Challis National Forest, ID; Upper North Fork HFRA Ecosystem... the potential for large-scale, high-intensity wildfires that threaten human life, property, and...

  5. RPD: Reusable Pseudo-Id Distribution for a Secure and Privacy Preserving VANET

    Directory of Open Access Journals (Sweden)

    Sulaiman Ashraph

    2013-08-01

    Full Text Available In any VANET, security and privacy are the two fundamental issues. Obtaining efficient security in vehicular communication is essential without compromising privacy-preserving mechanisms. Designing a suitable protocol for VANET by having these two issues in mind is challenging because efficiency, unlinkablity and traceability are the three qualities having contradictions between them. In this paper, we introduce an efficient Reusable Pseudo-id Distribution (RPD scheme. The Trusted Authority (TA designating the Road Side Units (RSUs to generate n reusable pseudo ids and distribute them to the On Board Units (OBUs on request characterizes the proposed protocol. RSUs issue the aggregated hashes of all its valid pseudo-ids along with a symmetric shared key and a particular pseudo-id to each vehicle that enters into its coverage range. Through this the certificates attached to the messages can be eliminated and thus resulting in a significantly reduced packet size. The same anonymous keys can then be re-distributed by the RSUs episodically to other vehicles. We analyze the proposed protocol extensively to demonstrate its merits and efficiency.

  6. Enrolment Data of Disabled Students Of IGNOU: A Case Study Using ID3

    Directory of Open Access Journals (Sweden)

    Nidhi Chopra

    2013-06-01

    Full Text Available In this paper, a methodology based on ID3 – a decision based learning technique for classification of disabled students of IGNOU has been evolved, for creating peer-to-peer groups. This can facilitate an environment for mutual help and academic interaction. The purpose is to promote blended social learning.

  7. Support and Self-Efficacy among Latino and White Parents of Children with ID

    Science.gov (United States)

    Cohen, Shana R.; Holloway, Susan D.; Dominguez-Pareto, Irenka; Kuppermann, Miriam

    2015-01-01

    Research indicates that mothers of children with ID who receive familial support experience less stress than those who receive less support. Less is known about the relation of support to mothers' evaluation of parenting self-efficacy, particularly in Latino families. We examined the relationship of different types of family support to life…

  8. 61 FR 42052 - Owyhee Resource Area, ID; Resource Management Plan, etc.

    Science.gov (United States)

    1996-08-13

    ... Bureau of Land Management Owyhee Resource Area, ID; Resource Management Plan, etc. AGENCY: Bureau of Land... Management Plan (RMP) and associated draft Environmental Impact Statement (EIS) for the Owyhee Resource Area... be sent to: Owyhee Area Manager, Bureau of Land Management, Boise Field Office, 3948...

  9. 70 FR 9098 - Notice of Realty Action, Sale of Public Land in Owyhee County, ID

    Science.gov (United States)

    2005-02-24

    ... Bureau of Land Management Notice of Realty Action, Sale of Public Land in Owyhee County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action, Sale of Public Land in Owyhee... located in Owyhee County, Idaho is suitable for direct sale to Owyhee County under Sections 203 and 209...

  10. 81 FR 23746 - Temporary Road Closure on Public Lands in Owyhee County, ID

    Science.gov (United States)

    2016-04-22

    ... Bureau of Land Management Temporary Road Closure on Public Lands in Owyhee County, ID AGENCY: Bureau of... 1-mile road segment that crosses public lands located in Owyhee County, Idaho, approximately 5 miles... the Owyhee Field Office, 20 First Avenue West, Marsing, Idaho, 83639. National Environmental...

  11. 61 FR 11862 - Shooting Closures and Restrictions in Ada, Canyon, Elmore, and Owyhee Counties, ID

    Science.gov (United States)

    1996-03-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Shooting Closures and Restrictions in Ada, Canyon, Elmore, and Owyhee Counties, ID AGENCY: Bureau of Land... Bruneau, Kuna, and Owyhee Management Framework Plans. Violation of this order is punishable by a fine...

  12. 77 FR 75654 - Notice of Temporary Closures on Public Lands in Owyhee County, ID

    Science.gov (United States)

    2012-12-21

    ... Bureau of Land Management Notice of Temporary Closures on Public Lands in Owyhee County, ID AGENCY... are in effect on public lands administered by the Owyhee Field Office, Bureau of Land Management (BLM... contact Loretta Chandler, Owyhee Field Office Manager at 20 First Ave. West, Marsing, Idaho, 83639,...

  13. Identification of an active ID-like group of SINEs in the mouse.

    Science.gov (United States)

    Kass, David H; Jamison, Nicole

    2007-09-01

    The mouse genome consists of five known families of SINEs: B1, B2, B4/RSINE, ID, and MIR. Using RT-PCR we identified a germ-line transcript that demonstrates 92.7% sequence identity to ID (excluding primer sequence), yet a BLAST search identified numerous matches of 100% sequence identity. We analyzed four of these elements for their presence in orthologous genes in strains and subspecies of Mus musculus as well as other species of Mus using a PCR-based assay. All four analyzed elements were identified either only in M. musculus or exclusively in both M. musculus and M. domesticus, indicative of recent integrations. In conjunction with the identification of transcripts, we present an active ID-like group of elements that is not derived from the proposed BC1 master gene of ID elements. A BLAST of the rat genome indicated that these elements were not in the rat. Therefore, this family of SINEs has recently evolved, and since it has thus far been observed mainly in M. musculus, we refer to this family as MMIDL.

  14. BICM-ID with Physical Layer Network Coding in TWR Free Space Optical Communication Links

    Directory of Open Access Journals (Sweden)

    Alaa A. Saeed Al-Rubaie

    2017-07-01

    Full Text Available Physical layer network coding (PNC is a promising technique to improve the network throughput in a two-way relay (TWR channel for two users to exchange messages across a wireless network. The PNC technique incorporating a TWR channel is embraced by a free space optical (FSO communication link for full utilization of network resources, namely TWR-FSO PNC. In this paper, bit interleaved coded modulation with iterative decoding (BICM-ID is adopted to combat the deleterious effect of the turbulence channel by saving the message being transmitted to increase the reliability of the system. Moreover, based on this technique, comparative studies between end-to-end BICM-ID code, non-iterative convolutional coded and uncoded systems are carried out. Furthermore, this paper presents the extrinsic information transfer (ExIT charts to evaluate the performance of BICM-ID code combined with the TWR-FSO PNC system. The simulation results show that the proposed scheme can achieve a significant bit error rate (BER performance improvement through the introduction of an iterative process between a soft demapper and decoder. Similarly, Monte Carlo simulation results are provided to support the findings. Subsequently, the ExIT functions of the two receiver components are thoroughly analysed for a variety of parameters under the influence of a turbulence-induced channel fading, demonstrating the convergence behaviour of BICM-ID to enable the TWR-FSO PNC system, effectively mitigating the impact of the fading turbulence channel.

  15. 75 FR 57053 - Camas National Wildlife Refuge, Jefferson County, ID; Comprehensive Conservation Plan and...

    Science.gov (United States)

    2010-09-17

    ... Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... prepare a comprehensive conservation plan (CCP) for Camas National Wildlife Refuge (refuge) in Hamer, ID... Refuge System, consistent with sound principles of fish and wildlife management, conservation,...

  16. nuID: a universal naming scheme of oligonucleotides for Illumina, Affymetrix, and other microarrays

    Directory of Open Access Journals (Sweden)

    Kibbe Warren A

    2007-05-01

    Full Text Available Abstract Background Oligonucleotide probes that are sequence identical may have different identifiers between manufacturers and even between different versions of the same company's microarray; and sometimes the same identifier is reused and represents a completely different oligonucleotide, resulting in ambiguity and potentially mis-identification of the genes hybridizing to that probe. Results We have devised a unique, non-degenerate encoding scheme that can be used as a universal representation to identify an oligonucleotide across manufacturers. We have named the encoded representation 'nuID', for nucleotide universal identifier. Inspired by the fact that the raw sequence of the oligonucleotide is the true definition of identity for a probe, the encoding algorithm uniquely and non-degenerately transforms the sequence itself into a compact identifier (a lossless compression. In addition, we added a redundancy check (checksum to validate the integrity of the identifier. These two steps, encoding plus checksum, result in an nuID, which is a unique, non-degenerate, permanent, robust and efficient representation of the probe sequence. For commercial applications that require the sequence identity to be confidential, we have an encryption schema for nuID. We demonstrate the utility of nuIDs for the annotation of Illumina microarrays, and we believe it has universal applicability as a source-independent naming convention for oligomers. Reviewers This article was reviewed by Itai Yanai, Rong Chen (nominated by Mark Gerstein, and Gregory Schuler (nominated by David Lipman.

  17. Epigenetic regulation of ID4 in the determination of the BRCAness phenotype in breast cancer.

    Science.gov (United States)

    Branham, M T; Campoy, E; Laurito, S; Branham, R; Urrutia, G; Orozco, J; Gago, F; Urrutia, R; Roqué, M

    2016-01-01

    BRCAness breast tumors represent a group of sporadic tumors characterized by a reduction in BRCA1 gene expression. As BRCA1 is involved in double-strand breaks (DSBs) repair, dysfunctional BRCA pathway could make a tumor sensitive to DNA damaging drugs (e.g., platinum agents). Thus, accurately identifying BRCAness could contribute to therapeutic decision making in patients harboring these tumors. The purpose of this study was to identify if BRCAness tumors present a characteristic methylation profile and/or were related to specific clinico-pathological features. BRCAness was measured by MLPA in 63 breast tumors; methylation status of 98 CpG sites within 84 cancer-related genes was analyzed by MS-MLPA. Protein and mRNA expressions of the selected genes were measured by quantitative real-time PCR and Western Blot. BRCAness was associated with younger age, higher nuclear pleomorphism, and triple-negative (TN) status. Epigenetically, we found that the strongest predictors for BRCAness tumors were the methylations of MLH1 and PAX5 plus the unmethylations of CCND2 and ID4. We determined that ID4 unmethylation correlated with the expression levels of both its mRNA and protein. We observed an inverse relation between the expressions of ID4 and BRCA1. To the best of our knowledge, this is the first report suggesting an epigenetic regulation of ID4 in BRCAness tumors. Our findings give new information of BRCAness etiology and encourage future studies on potential drug targets for BRCAness breast tumors.

  18. Espen Schaannings Foucault: Idéhistoriske intervensjoner i den norske Foucault-resepsjonen

    OpenAIRE

    Lillebø, Jonas Gamborg; Vik, Bjørnar Mortensen

    2009-01-01

    Artikkelen konsentrerer seg om et sentralt problem: Foucault som historiker og som filosof. Problemet aktualiseres ved en kritisk gjennomgang av Espen Schaannings lesing og formidling av Foucault som idéhistorisk intervenør. Er dette en for generaliserende lesning? Og er dette holdbart som en allmenn teori om historievitenskap?

  19. 78 FR 77024 - Telemarketing Sales Rule; Notice of Termination of Caller ID Rulemaking

    Science.gov (United States)

    2013-12-20

    ...' Caller ID displays, subjecting them to consumer complaints and the loss of business goodwill.\\16\\ \\14\\ E...., Herb Weisbaum, Why aren't phone companies doing more to block robocalls?, NBC News, July 17, 2013, www.nbcnews.com/business/why-arent-phone-companies-doing-more-block-robocalls-6C10641251 ; www.nomorobo.com...

  20. 76 FR 23321 - New Sweden Irrigation District, ID; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2011-04-26

    ... Energy Regulatory Commission New Sweden Irrigation District, ID; Notice of Preliminary Permit Application..., 2011, New Sweden Irrigation District filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of the New...

  1. Validation of the Inventory of Depressive Symptomatology (IDS) in Cocaine Dependent Inmates.

    Science.gov (United States)

    Suris, Alina; Kashner, T. Michael; Gillaspy, James A., Jr.; Biggs, Melanie; Rush, A. John

    2001-01-01

    While the reliability and validity of Inventory of Depressive Symptomatology (IDS) scores have been established with outpatient adults being treated in community psychiatric clinics, it has not been used in special or dually diagnosed populations. Establishes internal consistency, concurrent validity, and construct validity for both the clinical…

  2. A Provably Secure Revocable ID-Based Authenticated Group Key Exchange Protocol with Identifying Malicious Participants

    Directory of Open Access Journals (Sweden)

    Tsu-Yang Wu

    2014-01-01

    Full Text Available The existence of malicious participants is a major threat for authenticated group key exchange (AGKE protocols. Typically, there are two detecting ways (passive and active to resist malicious participants in AGKE protocols. In 2012, the revocable identity- (ID- based public key system (R-IDPKS was proposed to solve the revocation problem in the ID-based public key system (IDPKS. Afterwards, based on the R-IDPKS, Wu et al. proposed a revocable ID-based AGKE (RID-AGKE protocol, which adopted a passive detecting way to resist malicious participants. However, it needs three rounds and cannot identify malicious participants. In this paper, we fuse a noninteractive confirmed computation technique to propose the first two-round RID-AGKE protocol with identifying malicious participants, which is an active detecting way. We demonstrate that our protocol is a provably secure AGKE protocol with forward secrecy and can identify malicious participants. When compared with the recently proposed ID/RID-AGKE protocols, our protocol possesses better performance and more robust security properties.

  3. Perspectives on the Role of Geo-Technologies for Addressing Contemporary Urban Issues: Implications for IDS

    NARCIS (Netherlands)

    Pfeffer, K.; Verrest, H.

    2016-01-01

    Contemporary patterns of urbanization come with many challenges regarding the quality of urban life, especially with respect to the provision of urban infrastructures and housing, exposure to environmental risks and urban inequalities. In International Development Studies (IDS) it is understood that

  4. Typing of Amerindian Kichwas and Mestizos from Ecuador with the SNPforID multiplex

    DEFF Research Database (Denmark)

    Poulsen, Lena; Børsting, Claus; Tomas, Carmen

    2011-01-01

    A total of 119 unrelated individuals from two of the major ethnic groups in Ecuador were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex using the SNapShot® assay. Of the above, 42 samples originated from Mestizos (an admixed population) and the remaining...

  5. The Critical Role of the ID in Interactive Television: The Value of Immediacy.

    Science.gov (United States)

    Murphy, Karen L.; Farr, Charlotte W.

    The instructional designer (ID) plays a critical role in the development and viability of each course taught at a distance, particularly in the incorporation of immediacy behaviors, or communication behaviors that convey approachability and communicate interpersonal warmth and closeness. Faculty development must be fostered to encourage immediacy…

  6. Hizbollah lubab : "Me tahame ameeriklastega häid suhteid" / Mohamad Afif ; interv. Ivar Soopan

    Index Scriptorium Estoniae

    Afif, Mohamad

    2005-01-01

    Liibanoni shiiitide organisatsiooni Hizbollah meediasuhete direktor ütleb, et Hizbollah ei ole terroriorganisatsioon. Religioosse ja poliitilise grupina tahab Hizbollah häid suhteid teistega kõikjal maailmas, kuid probleem on poliitikas, selles, kuidas USA suhtub nende regiooni, tõekspidamistesse

  7. KorAP: the new corpus analysis platform at IDS Mannheim

    DEFF Research Database (Denmark)

    Banski, Piotr; Bingel, Joachim; Diewald, Nils

    2013-01-01

    The KorAP project (“Korpusanalyseplattform der nächste Generation”, “Corpus-analysis platform of the next generation”), carried out at the Institut für Deutsche Sprache (IDS) in Mannheim, Germany, has as its goal the development of a modern, state-of-the-art corpus-analysis platform, capable...

  8. 75 FR 22625 - Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID

    Science.gov (United States)

    2010-04-29

    ... Bureau of Land Management Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID AGENCY... for direct (non-competitive) sale to Todd and Bridget Buschhorn under the provisions of the Federal...: In order to ensure consideration in the environmental analysis of the proposed sale, comments must...

  9. 76 FR 29784 - Notice of Realty Action; Direct Sale of Public Lands in Jerome County, ID

    Science.gov (United States)

    2011-05-23

    ... Bureau of Land Management Notice of Realty Action; Direct Sale of Public Lands in Jerome County, ID... being proposed for direct sale to Todd and Bridget Buschhorn in accordance with Sections 203 and 209 of..., and is not needed for any other Federal purposes. The direct sale will allow for the subject parcel...

  10. 78 FR 39767 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID

    Science.gov (United States)

    2013-07-02

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID AGENCY... proposed for direct sale to PORR in accordance with Sections 203 and 209 of the Federal Land Policy and... best be served by modified competitive bidding or direct (non-competitive) sale. In this instance,...

  11. 75 FR 71143 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID

    Science.gov (United States)

    2010-11-22

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID AGENCY.... SUPPLEMENTARY INFORMATION: The following described public land is being proposed for direct sale to the Animal... Animal Shelter. Regulations contained in 43 CFR 2711.3-3 permit direct sales when a competitive sale...

  12. Coupling Molecular Modeling to the Traditional "IR-ID" Exercise in the Introductory Organic Chemistry Laboratory

    Science.gov (United States)

    Stokes-Huby, Heather; Vitale, Dale E.

    2007-01-01

    This exercise integrates the infrared unknown identification ("IR-ID") experiment common to most organic laboratory syllabi with computer molecular modeling. In this modification students are still required to identify unknown compounds from their IR spectra, but must additionally match some of the absorptions with computed frequencies they…

  13. Hizbollah lubab : "Me tahame ameeriklastega häid suhteid" / Mohamad Afif ; interv. Ivar Soopan

    Index Scriptorium Estoniae

    Afif, Mohamad

    2005-01-01

    Liibanoni shiiitide organisatsiooni Hizbollah meediasuhete direktor ütleb, et Hizbollah ei ole terroriorganisatsioon. Religioosse ja poliitilise grupina tahab Hizbollah häid suhteid teistega kõikjal maailmas, kuid probleem on poliitikas, selles, kuidas USA suhtub nende regiooni, tõekspidamistesse

  14. External validity of the Indonesian Wechsler Adult Intelligence Scale - Fourth edition (WAIS-IV-ID)

    NARCIS (Netherlands)

    Suwartono, C.; Hidajat, L.L.; Halim, M.S.; Hendriks, M.P.H.; Kessels, R.P.C.

    2016-01-01

    The Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV-ID) has been adapted and proved to be valid for its internal structure for Indonesian population. The same structure found as in the American WAIS-IV (WAIS-IV-US; Suwartono, Hendriks, Hidajat, Halim, & Kessels, 2015). Despite its strong i

  15. OpenID connect as a security service in Cloud-based diagnostic imaging systems

    Science.gov (United States)

    Ma, Weina; Sartipi, Kamran; Sharghi, Hassan; Koff, David; Bak, Peter

    2015-03-01

    The evolution of cloud computing is driving the next generation of diagnostic imaging (DI) systems. Cloud-based DI systems are able to deliver better services to patients without constraining to their own physical facilities. However, privacy and security concerns have been consistently regarded as the major obstacle for adoption of cloud computing by healthcare domains. Furthermore, traditional computing models and interfaces employed by DI systems are not ready for accessing diagnostic images through mobile devices. RESTful is an ideal technology for provisioning both mobile services and cloud computing. OpenID Connect, combining OpenID and OAuth together, is an emerging REST-based federated identity solution. It is one of the most perspective open standards to potentially become the de-facto standard for securing cloud computing and mobile applications, which has ever been regarded as "Kerberos of Cloud". We introduce OpenID Connect as an identity and authentication service in cloud-based DI systems and propose enhancements that allow for incorporating this technology within distributed enterprise environment. The objective of this study is to offer solutions for secure radiology image sharing among DI-r (Diagnostic Imaging Repository) and heterogeneous PACS (Picture Archiving and Communication Systems) as well as mobile clients in the cloud ecosystem. Through using OpenID Connect as an open-source identity and authentication service, deploying DI-r and PACS to private or community clouds should obtain equivalent security level to traditional computing model.

  16. The Id, Ego and Super-Ego in "Pride and Prejudice"

    Science.gov (United States)

    Liang, Yamin

    2011-01-01

    This paper mainly analyses the the id, ego, and super-ego which exists in the main character Elizabeth from several aspects, such as her pursuit for love, her prejudice towards Mr. Darcy, and the changes in her attitudes towards Wickham. This analysis helps readers appreciate this masterpiece from a different aspect which is related to the…

  17. System Virtualization and Efficient ID Transmission Method for RFID Tag Infrastructure Network

    CERN Document Server

    Kuribayashi, Shin-ichi

    2010-01-01

    The use of RFID tag which identifies a thing and an object will be expanded with progress of ubiquitous society, and it is necessary to study how to construct RFID network system as a social infrastructure like the Internet. First, this paper proposes the virtualization method of RFID tag network system to enable the same physical RFID network system to be used by multiple different service systems. The system virtualization not only reduces the system cost but also can dramatically reduce the installation space of physical readers and the operation cost. It is proposed that all equipments in the RFID network system except RFID tag could be shared with the conventional virtual technologies. Then, this paper proposes the conditional tag ID processing and the efficient tag ID transmission method which can greatly reduce the processing time and processing load in RFID tag Infrastructure network The conditional tag ID processing allows that tag ID is valid only at a certain time zone of day or in a certain area. ...

  18. 77 FR 56608 - Designation for the Pocatello, ID; Evansville, IN; and Salt Lake City, UT Areas

    Science.gov (United States)

    2012-09-13

    ... regarding the designation criteria in section 79(f) of the USGSA (7 U.S.C. 79(f)) and determined that Idaho... location and Designation Designation Official agency telephone start end Idaho Pocatello, ID (208) 233-8303... unless terminated by the Secretary; however, designations may be renewed according to the criteria...

  19. 77 FR 55813 - Transition of DOE-ID Public Reading Room

    Science.gov (United States)

    2012-09-11

    ... Library at 1776 Science Center Drive, Idaho Falls, ID 83401, beginning September 1, 2012. Access to documents will also be electronically accessible through the World Wide Web. For direction in accessing documents electronically through the World Wide Web, please refer to the Idaho Operations FOIA Web site...

  20. 76 FR 13976 - Eastern Idaho Resource Advisory Committee; Caribou-Targhee National Forest, Idaho Falls, ID

    Science.gov (United States)

    2011-03-15

    ... Forest Service Eastern Idaho Resource Advisory Committee; Caribou-Targhee National Forest, Idaho Falls, ID AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: Pursuant to the authorities in... Self-Determination Act of 2000 (Pub. L. 106-393) the Caribou-Targhee National Forests' Eastern Idaho...