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Sample records for leigh elwood miller

  1. Leigh's Disease

    Science.gov (United States)

    ... broad range of basic and clinical research on neurogenetic disorders such as Leigh's disease. The goal of ... broad range of basic and clinical research on neurogenetic disorders such as Leigh's disease. The goal of ...

  2. Elwood Murray: Pioneering Methodologist in Communication

    Science.gov (United States)

    Brownell, Judi

    2014-01-01

    Elwood Murray (1897-1988) was a pioneer in communication education. Beginning in the 1930s, he applied nontraditional methods in the speech classroom to encourage students to internalize and apply what they learned, and to view knowledge holistically. Drawing on the work of Kunkel, Moreno, Lewin, and Korzybski, Murray focused on developing skills…

  3. Adult onset Leigh syndrome

    Directory of Open Access Journals (Sweden)

    Pandit Lekha

    2007-01-01

    Full Text Available Leigh syndrome is a rare progressive mitochondrial disorder of oxidative metabolism. Though it has been reported in infancy and childhood, it is rarely described in adults. The authors describe a patient who had clinical and magnetic resonance imaging features diagnostic of Leigh syndrome, with supportive biochemical and muscle histochemistry evidence.

  4. Genetics Home Reference: Leigh syndrome

    Science.gov (United States)

    ... by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within two ... Can changes in mitochondrial DNA affect health and development? More about Mutations and Health Inheritance Pattern Leigh ...

  5. A multicenter study on Leigh syndrome

    DEFF Research Database (Denmark)

    Sofou, Kalliopi; De Coo, Irenaeus F M; Isohanni, Pirjo

    2014-01-01

    to thrive, brainstem lesions on neuroimaging and intensive care treatment were significantly associated with poorer survival. CONCLUSIONS: This is a multicenter study performed in a large cohort of patients with Leigh syndrome. Our data help define the natural history of Leigh syndrome and identify novel...

  6. The "double panda" sign in Leigh disease.

    Science.gov (United States)

    Sonam, Kothari; Bindu, P S; Gayathri, Narayanappa; Khan, Nahid Akhtar; Govindaraju, C; Arvinda, Hanumanthapura R; Nagappa, Madhu; Sinha, Sanjib; Thangaraj, K; Taly, Arun B

    2014-07-01

    Although the "face of the giant panda" sign on magnetic resonance imaging (MRI) is traditionally considered to be characteristic of Wilson disease, it has also been reported in other metabolic disorders. This study describes the characteristic "giant panda" sign on MRI in a child with Leigh disease. The diagnosis was based on the history of neurological regression; examination findings of oculomotor abnormalities, hypotonia, and dystonia; raised serum lactate levels; and characteristic brain stem and basal ganglia signal changes on MRI. The midbrain and pontine tegmental signal changes were consistent with the "face of the giant panda and her cub" sign. In addition to Wilson disease, metabolic disorders such as Leigh disease should also be considered in the differential diagnosis of this rare imaging finding. © The Author(s) 2013.

  7. Schizophrenia and Leigh syndrome, a simple comorbidity or the ...

    African Journals Online (AJOL)

    cytochrome c oxidase deficiency". Few psychiatric disorders have been defined that are associated with Leigh syndrome. The objective of this work is to study relations between mitochondrial dysfunction and psychiatric disorders. It was a 20 year ...

  8. Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome.

    Science.gov (United States)

    Bindu, P S; Taly, A B; Sonam, K; Govindaraju, C; Arvinda, H R; Gayathri, N; Bharath, M M Srinivas; Ranjith, D; Nagappa, M; Sinha, S; Khan, N A; Thangaraj, K

    2014-02-01

    Bilateral hypertrophic olivary degeneration on brain MRI has been reported in a few metabolic, genetic and neurodegenerative disorders, including mitochondrial disorders. In this report, we sought to analyse whether bilateral symmetrical inferior olivary nucleus hypertrophy is specifically associated with mitochondrial disorders in children. This retrospective study included 125 children (mean age, 7.6 ± 5 years; male:female, 2.6:1) diagnosed with various metabolic and genetic disorders during 2005-2012. The routine MRI sequences (T1 weighted, T2 weighted and fluid-attenuated inversion-recovery sequences) were analysed for the presence of bilateral symmetrical olivary hypertrophy and central tegmental tract or dentate nuclei signal changes. The other imaging findings and the final diagnoses were noted. The cohort included patients with Leigh and Leigh-like syndrome (n = 25), other mitochondrial diseases (n = 25), Wilson disease (n = 40), Type 1 glutaric aciduria (n = 14), maple syrup urine disease (n = 13), giant axonal neuropathy (n = 5) and L-2 hydroxy glutaric aciduria (n = 3). Bilateral inferior olivary nucleus hypertrophy was noted in 10 patients, all of whom belonged to the Leigh and Leigh-like syndrome group. Bilateral hypertrophic olivary degeneration on MRI is relatively often, but not routinely, seen in children with Leigh and Leigh-like syndrome. Early detection of this finding by radiologists and physicians may facilitate targeted metabolic testing in these children. This article highlights the occurrence of bilateral hypertrophic olivary nucleus degeneration on MRI in children with Leigh and Leigh-like syndrome, compared with other metabolic disorders.

  9. A multicenter study on Leigh syndrome: Disease course and predictors of survival

    NARCIS (Netherlands)

    K. Sofou (Kalliopi); I.F.M. de Coo (René); M.K. Isohanni (Matti); M. Ostergaard; K. Naess (Karin); L. de Meirleir (Linda); C. Tzoulis (Charalampos); J. Uusimaa (Johanna); I. de Angst (Isabel); T. Lönnqvist (Tuula); H. Pihko (Helena); K. Mankinen (Katariina); L.A. Bindoff (Laurence Albert); M. Tulinius (Már); N. Darin (Niklas)

    2014-01-01

    textabstractBackground: Leigh syndrome is a progressive neurodegenerative disorder, associated with primary or secondary dysfunction of the mitochondrial oxidative phosphorylation. Despite the fact that Leigh syndrome is the most common phenotype of mitochondrial disorders in children, longitudinal

  10. A rare mitochondrial disorder: Leigh sydrome - a case report

    Directory of Open Access Journals (Sweden)

    Shrikhande Dhananjay Y

    2010-09-01

    Full Text Available Abstract Leigh syndrome is a rare progressive neurodegenerative, mitochondrial disorder of childhood with only a few cases documented from India. The clinical presentation of Leigh syndrome is highly variable. However, in most cases it presents as a progressive neurological disease with motor and intellectual developmental delay and signs and symptoms of brain stem and/or basal ganglia involvement. Raised lactate levels in blood and/or cerebrospinal fluid is noted. It is the neuroimaging, mainly the Magnetic Resonance Imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the diagnosis. Here, we report a case of 7 months old female child presenting to us with status epilepticus, delayed developmental milestones and regression of the achieved milestones suspected to be a case of neurodegenerative disorder, which on MRI was diagnosed as Leigh syndrome.

  11. Millerism - an historical enigma?

    Directory of Open Access Journals (Sweden)

    Ingemar Lindén

    1975-01-01

    Full Text Available It is a wellknown fact in history that strong bias in the writers and a wishful thinking radically prevent the analysis of any event or religious activity. For this reason Catholic ecclesiastical writers of the old school distorted the role of Martin Luther and his movement; likewise the Radical Reformation fared badly in old handbooks, whether they were composed by Catholics or Lutherans. Again the same principle applies to many of the modern "sects" in America and in Europe. Millerism is an excellent case for illustrating this unfelicitious type of writing. The layman-evangelist William Miller (1782-1849 claimed that the world would never be converted; only the second coming of Christ could usher in the millennium. In order to obtain a better understanding of Millerism, the movement should be divided into three main periods, which differed in character. At first, Miller's own development needs to be ascertained. Though he lacked any thorough intellectual training and remained an autodidact, he nevertheless belonged to the wide range of middle class Yankees. To be sure, Miller lived not too far from the famous frontier in his youth, but despite preconceived ideas in some writers, Miller had his cultural roots in the built-up areas of a New England society. The second important stratum in his personality was the warm Baptist revivalism, which prevailed in his home. Deism and revivalism thus contended for the supremacy of his soul; admitting the later dominance of evangelical revivalism, reason and order continued to hold a place in his mental set-up.

  12. Recurrent Miller Fisher syndrome.

    Science.gov (United States)

    Madhavan, S; Geetha; Bhargavan, P V

    2004-07-01

    Miller Fisher syndrome (MFS) is a variant of Guillan Barre syndrome characterized by the triad of ophthalmoplegia, ataxia and areflexia. Recurrences are exceptional with Miller Fisher syndrome. We are reporting a case with two episodes of MFS within two years. Initially he presented with partial ophthalmoplegia, ataxia. Second episode was characterized by full-blown presentation characterized by ataxia, areflexia and ophthalmoplegia. CSF analysis was typical during both episodes. Nerve conduction velocity study was fairly within normal limits. MRI of brain was within normal limits. He responded to symptomatic measures initially, then to steroids in the second episode. We are reporting the case due to its rarity.

  13. Anesthetic considerations in Leigh disease: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Abdullah Sulieman Terkawi

    2012-01-01

    Full Text Available Leigh disease is an extremely rare disorder, characterized by a progressive neurodegenerative course, with subacute necrotizing encephalomyelopathy. It usually presents in infancy with developmental delay, seizures, dysarthria, and ataxia. These patients may also develop episodes of lactic acidosis that usually lead to respiratory failure and death. Due to the rarity of the condition, the most appropriate anesthetic plan remains unclear. We present a patient with Leigh disease, who required general anesthesia. The pathogenesis of the disease is discussed and previous reports of perioperative care from the literature are reviewed.

  14. Premature Ovarian Failure in French Canadian Leigh Syndrome.

    Science.gov (United States)

    Ghaddhab, Chiraz; Morin, Charles; Brunel-Guitton, Catherine; Mitchell, Grant A; Van Vliet, Guy; Huot, Céline

    2017-05-01

    In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and progression should be evaluated in girls with mitochondrial diseases. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. SINDROME DE MILLER DIEKER.

    OpenAIRE

    María Corfio P.; Romina Romeo G.

    2007-01-01

    El síndrome de Miller Dieker es una patología genética pocofrecuente, descrita en 1963 para referirse al fenotipo específicoasociado a lisencefalia tipo I y anomalías craneofaciales. Suincidencia exacta se desconoce, pero la incidencia de todas laslisencefalias es alrededor de 1/100.000 recién nacidos (1). Seorigina por una delección o mutación en el cromosoma 17 p.13.3 específicamente el gen LIS1, responsable de un espectro deenfermedades que involucran la migración neuronal y que en sumáxim...

  16. ECHS1 mutations in Leigh disease: a new inborn error of metabolism affecting valine metabolism

    NARCIS (Netherlands)

    Peters, Heidi; Buck, Nicole; Wanders, Ronald; Ruiter, Jos; Waterham, Hans; Koster, Janet; Yaplito-Lee, Joy; Ferdinandusse, Sacha; Pitt, James

    2014-01-01

    Two siblings with fatal Leigh disease had increased excretion of S-(2-carboxypropyl)cysteine and several other metabolites that are features of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency, a rare defect in the valine catabolic pathway associated with Leigh-like disease. However, this

  17. The Changing Face of Malaysian Crafts, Barbara Leigh

    OpenAIRE

    Munan, Heidi

    2017-01-01

    This new work on Malaysia’s material culture brings the country’s handicrafts from the past into the present, and the future. The main branches of Malaysian handicrafts (particularly textile and metal production) are on the whole well documented as far as their origins are concerned; there is however a tendency to cut off by the mid-twentieth century, and regard later production as ‘modern’ and, by implication, ‘inferior.’ That is not how Leigh sees the Malaysian handicrafts scene. She traces...

  18. [The Durkheim Test. Remarks on Susan Leigh Star's Boundary Objects].

    Science.gov (United States)

    Gießmann, Sebastian

    2015-09-01

    The article reconstructs Susan Leigh Star's conceptual work on the notion of 'boundary objects'. It traces the emergence of the concept, beginning with her PhD thesis and its publication as Regions of the Mind in 1989. 'Boundary objects' attempt to represent the distributed, multifold nature of scientific work and its mediations between different 'social worlds'. Being addressed to several 'communities of practice', the term responded to questions from Distributed Artificial Intelligence in Computer Science, Workplace Studies and Computer Supported Cooperative Work (CSCW), and microhistorical approaches inside the growing Science and Technology Studies. Yet the interdisciplinary character and interpretive flexibility of Star’s invention has rarely been noticed as a conceptual tool for media theory. I therefore propose to reconsider Star's 'Durkheim test' for sociotechnical media practices.

  19. An Interview with Ron Miller.

    Science.gov (United States)

    Mercogliano, Chris; Becker, Ellen; Leue, Mary

    1998-01-01

    Ron Miller, founder of the journal "Holistic Education Review," discusses his intellectual background in humanistic psychology and historical studies, definition of holism in education, the holistic approach as an answer to the reductionist and fragmented modern era, founding of the journal as a form of activism, and the incremental nature of…

  20. The neuroimaging of Leigh syndrome: case series and review of the literature

    International Nuclear Information System (INIS)

    Bonfante, Eliana; Riascos, Roy F.; Koenig, Mary Kay; Adejumo, Rahmat B.; Perinjelil, Vinu

    2016-01-01

    Leigh syndrome by definition is (1) a neurodegenerative disease with variable symptoms, (2) caused by mitochondrial dysfunction from a hereditary genetic defect and (3) accompanied by bilateral central nervous system lesions. A genetic etiology is confirmed in approximately 50% of patients, with more than 60 identified mutations in the nuclear and mitochondrial genomes. Here we review the clinical features and imaging studies of Leigh syndrome and describe the neuroimaging findings in a cohort of 17 children with genetically confirmed Leigh syndrome. MR findings include lesions in the brainstem in 9 children (53%), basal ganglia in 13 (76%), thalami in 4 (24%) and dentate nuclei in 2 (12%), and global atrophy in 2 (12%). The brainstem lesions were most frequent in the midbrain and medulla oblongata. With follow-up an increased number of lesions from baseline was observed in 7 of 13 children, evolution of the initial lesion was seen in 6, and complete regression of the lesions was seen in 3. No cerebral white matter lesions were found in any of the 17 children. In concordance with the literature, we found that Leigh syndrome follows a similar pattern of bilateral, symmetrical basal ganglia or brainstem changes. Lesions in Leigh syndrome evolve over time and a lack of visible lesions does not exclude the diagnosis. Reversibility of lesions is seen in some patients, making the continued search for treatment and prevention a priority for clinicians and researchers. (orig.)

  1. The neuroimaging of Leigh syndrome: case series and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Bonfante, Eliana; Riascos, Roy F. [The University of Texas Medical School at Houston, Department of Diagnostic and Interventional Imaging, Houston, TX (United States); Koenig, Mary Kay [The University of Texas Medical School at Houston, Department of Pediatrics, Division of Child and Adolescent Neurology, Mitochondrial Center of Excellence Leigh Clinic, Houston, TX (United States); Adejumo, Rahmat B.; Perinjelil, Vinu [The University of Texas Medical School at Houston, Department of Pediatrics, Division of Child and Adolescent Neurology, Houston, TX (United States)

    2016-04-15

    Leigh syndrome by definition is (1) a neurodegenerative disease with variable symptoms, (2) caused by mitochondrial dysfunction from a hereditary genetic defect and (3) accompanied by bilateral central nervous system lesions. A genetic etiology is confirmed in approximately 50% of patients, with more than 60 identified mutations in the nuclear and mitochondrial genomes. Here we review the clinical features and imaging studies of Leigh syndrome and describe the neuroimaging findings in a cohort of 17 children with genetically confirmed Leigh syndrome. MR findings include lesions in the brainstem in 9 children (53%), basal ganglia in 13 (76%), thalami in 4 (24%) and dentate nuclei in 2 (12%), and global atrophy in 2 (12%). The brainstem lesions were most frequent in the midbrain and medulla oblongata. With follow-up an increased number of lesions from baseline was observed in 7 of 13 children, evolution of the initial lesion was seen in 6, and complete regression of the lesions was seen in 3. No cerebral white matter lesions were found in any of the 17 children. In concordance with the literature, we found that Leigh syndrome follows a similar pattern of bilateral, symmetrical basal ganglia or brainstem changes. Lesions in Leigh syndrome evolve over time and a lack of visible lesions does not exclude the diagnosis. Reversibility of lesions is seen in some patients, making the continued search for treatment and prevention a priority for clinicians and researchers. (orig.)

  2. Respiratory chain complex I deficiency due to NDUFA12 mutations as a new cause of Leigh syndrome

    DEFF Research Database (Denmark)

    Ostergaard, Elsebet; Rodenburg, Richard J; van den Brand, Mariël

    2011-01-01

    This study investigated a girl with Leigh syndrome born to first-cousin parents of Pakistani descent with an isolated respiratory chain complex I deficiency in muscle and fibroblasts. Her early development was delayed, and from age 2 years she started losing motor abilities. Cerebral MRI showed...... basal ganglia lesions typical of Leigh syndrome....

  3. Reading the Miller's Tale Reading the Miller's Tale

    Directory of Open Access Journals (Sweden)

    Valerie Edden

    2008-04-01

    Full Text Available Modern narrative theory has provided new ways of analysing stories and a new critical vocabulary for discussing narratives. Some such theories emphasise the way in which the reader is involved in the act of reading a narrative, bringing skills and assumptions to the text which enable him to interpret the words which make up the story. Traditionally we have tended to confine literary analysis to the words on the page; narratologists and structuralists invite us to examine also what the reader brings to the text. Such an analysis not only interprets the texts under discussion but also helsps to lay bare the assumptions of the reader. This paper will provide an analysis of Chaucer's Miller's Tale using a heory of narrative analogous with transformation! grammar. Modern narrative theory has provided new ways of analysing stories and a new critical vocabulary for discussing narratives. Some such theories emphasise the way in which the reader is involved in the act of reading a narrative, bringing skills and assumptions to the text which enable him to interpret the words which make up the story. Traditionally we have tended to confine literary analysis to the words on the page; narratologists and structuralists invite us to examine also what the reader brings to the text. Such an analysis not only interprets the texts under discussion but also helsps to lay bare the assumptions of the reader. This paper will provide an analysis of Chaucer's Miller's Tale using a heory of narrative analogous with transformation! grammar.

  4. Gait analysis in a mouse model resembling Leigh disease.

    Science.gov (United States)

    de Haas, Ria; Russel, Frans G; Smeitink, Jan A

    2016-01-01

    Leigh disease (LD) is one of the clinical phenotypes of mitochondrial OXPHOS disorders and also known as sub-acute necrotizing encephalomyelopathy. The disease has an incidence of 1 in 77,000 live births. Symptoms typically begin early in life and prognosis for LD patients is poor. Currently, no clinically effective treatments are available. Suitable animal and cellular models are necessary for the understanding of the neuropathology and the development of successful new therapeutic strategies. In this study we used the Ndufs4 knockout (Ndufs4(-/-)) mouse, a model of mitochondrial complex I deficiency. Ndusf4(-/-) mice exhibit progressive neurodegeneration, which closely resemble the human LD phenotype. When dissecting behavioral abnormalities in animal models it is of great importance to apply translational tools that are clinically relevant. To distinguish gait abnormalities in patients, simple walking tests can be assessed, but in animals this is not easy. This study is the first to demonstrate automated CatWalk gait analysis in the Ndufs4(-/-) mouse model. Marked differences were noted between Ndufs4(-/-) and control mice in dynamic, static, coordination and support parameters. Variation of walking speed was significantly increased in Ndufs4(-/-) mice, suggesting hampered and uncoordinated gait. Furthermore, decreased regularity index, increased base of support and changes in support were noted in the Ndufs4(-/-) mice. Here, we report the ability of the CatWalk system to sensitively assess gait abnormalities in Ndufs4(-/-) mice. This objective gait analysis can be of great value for intervention and drug efficacy studies in animal models for mitochondrial disease. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Reading the Miller's Tale Reading the Miller's Tale

    Directory of Open Access Journals (Sweden)

    Valerie Edden

    2008-04-01

    Full Text Available Modern narrative theory has provided new ways of analysing stories and a new critical vocabulary for discussing narratives. Some such theories emphasise the way in which the reader is involved in the act of reading a narrative, bringing skills and assumptions to the text which enable him to interpret the ords which make up the story. Traditionally we have tended to onfine literary analysis to the words on the page; arratologists and structuralists invite us to examine also what the reader brings to the text. Such an analysis not only nterprets the texts under discussion but also helps to lay bare the assumptions of the reader. This paper will provide an analysis of Chaucer's Miller's Tale using a theory of narrative analogous with transformational grammar.

  6. J. Hillis Miller's Virtual Reality of Reading

    Science.gov (United States)

    Fosso, Kurt; Harp, Jerry

    2012-01-01

    We set out to investigate Miller's curious assertion--curious for a deconstructionist committed to a critique of the old metaphysics of presence--that literary works preexist their being written down. We find a basis for this sense of the preexistence of the literary work in Miller's insights about the performative dynamics of reading and writing.…

  7. 76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

    Science.gov (United States)

    2011-08-09

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... his address] does not relieve the State of its constitutional obligation.'' ' '' Id. at 232 (quoting... unclaimed, the Government could have satisfied its constitutional obligation simply by mailing the Show...

  8. Assessment of Coastal and Urban Flooding Hazards Applying Extreme Value Analysis and Multivariate Statistical Techniques: A Case Study in Elwood, Australia

    Science.gov (United States)

    Guimarães Nobre, Gabriela; Arnbjerg-Nielsen, Karsten; Rosbjerg, Dan; Madsen, Henrik

    2016-04-01

    Traditionally, flood risk assessment studies have been carried out from a univariate frequency analysis perspective. However, statistical dependence between hydrological variables, such as extreme rainfall and extreme sea surge, is plausible to exist, since both variables to some extent are driven by common meteorological conditions. Aiming to overcome this limitation, multivariate statistical techniques has the potential to combine different sources of flooding in the investigation. The aim of this study was to apply a range of statistical methodologies for analyzing combined extreme hydrological variables that can lead to coastal and urban flooding. The study area is the Elwood Catchment, which is a highly urbanized catchment located in the city of Port Phillip, Melbourne, Australia. The first part of the investigation dealt with the marginal extreme value distributions. Two approaches to extract extreme value series were applied (Annual Maximum and Partial Duration Series), and different probability distribution functions were fit to the observed sample. Results obtained by using the Generalized Pareto distribution demonstrate the ability of the Pareto family to model the extreme events. Advancing into multivariate extreme value analysis, first an investigation regarding the asymptotic properties of extremal dependence was carried out. As a weak positive asymptotic dependence between the bivariate extreme pairs was found, the Conditional method proposed by Heffernan and Tawn (2004) was chosen. This approach is suitable to model bivariate extreme values, which are relatively unlikely to occur together. The results show that the probability of an extreme sea surge occurring during a one-hour intensity extreme precipitation event (or vice versa) can be twice as great as what would occur when assuming independent events. Therefore, presuming independence between these two variables would result in severe underestimation of the flooding risk in the study area.

  9. Charla Lancaster, Rebecca Miller join University Libraries

    OpenAIRE

    Purcell, Laura

    2010-01-01

    The University Libraries at Virginia Tech has named Charla Lancaster as director of assessment and library access services and Rebecca Miller as the college librarian for science, life sciences, and engineering.

  10. Mike Leigh' abordi-draama võitis Veneetsias Kuldlõvi / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2004-01-01

    Veneetsia 61. filmifestivali võitjad : Kuldlõvi sai inglase Mike Leigh "Vera Drake" (nimiosa eest ka parima naisnäitleja Coppa Volpi Imelda Stauntonile), Hõbelõvi läks hispaanlase Alejandro Amenabari filmile "Merele" (siit ka parima meesnäitleja au Javier Bardemile), režii eriauhinna sai Kim Ki-duk Lõuna-Koreast filmiga "Tühi maja" ("Bin jip")

  11. George A. Miller (1920-2012).

    Science.gov (United States)

    Pinker, Steven

    2013-09-01

    Presents an obituary for George A. Miller (1920-2012). Miller ranks among the most important psychologists of the 20th century. In addition to writing one of the best known papers in the history of psychology ("The Magical Number Seven, Plus or Minus Two: Some Limits on Our Capacity for Processing Information," published in Psychological Review in 1956), Miller also fomented the cognitive revolution, invented psycholinguistics and cognitive psychology, imported powerful ideas from the theories of information, communication, grammar, semantics, and artificial intelligence, and left us a sparkling oeuvre that proves that a rigorous scientist needn't write in soggy prose. Honors rained down on Miller. APA gave him the Award for Distinguished Scientific Contributions (1963), the American Psychological Foundation Gold Medal Award for Life Achievement in Psychological Science (1990), the William James Book Award (1992, for The Science of Words), and the Award for Lifetime Contributions to Psychology (2003), and named a prize after him, as did the Cognitive Neuroscience Society. Miller was also honored by the Association for Psychological Science and the American Speech and Hearing Association. In 2000, he won the John P. McGovern Award in the Behavioral Sciences from the American Association for the Advancement of Science, and in 1991, the National Medal of Science, the country's highest scientific honor. © 2013 APA, all rights reserved.

  12. Terry E. Miller on Thai Music.

    Science.gov (United States)

    Campbell, Patricia Shehan

    1994-01-01

    Reports on an interview with Terry E. Miller, a specialist on music of Thailand and other southeastern Asian nations. Discusses the culture, the role of music, and musical instruments of Thailand. Includes a list of resources and two lesson plans for teaching about Thai music. (CFR)

  13. (0,2) SCFTs from the Leigh-Strassler fixed point

    International Nuclear Information System (INIS)

    Bobev, Nikolay; Pilch, Krzysztof; Vasilakis, Orestis

    2014-01-01

    We show that there is a family of two-dimensional (0,2) SCFTs associated with twisted compactifications of the four-dimensional N=1 Leigh-Strassler fixed point on a closed hyperbolic Riemann surface. We calculate the central charges for this class of theories using anomalies and c-extremization. In a suitable truncation of the five-dimensional maximal supergravity, we construct supersymmetric AdS 3 solutions that are holographic duals of those two-dimensional (0,2) SCFTs. We also exhibit supersymmetric domain wall solutions that are holographically dual to the RG flows between the four-dimensional and two-dimensional theories.

  14. Cytochrome C oxydase deficiency: SURF1 gene investigation in patients with Leigh syndrome.

    Science.gov (United States)

    Maalej, Marwa; Kammoun, Thouraya; Alila-Fersi, Olfa; Kharrat, Marwa; Ammar, Marwa; Felhi, Rahma; Mkaouar-Rebai, Emna; Keskes, Leila; Hachicha, Mongia; Fakhfakh, Faiza

    2018-03-18

    Leigh syndrome (LS) is a rare progressive neurodegenerative disorder occurring in infancy. The most common clinical signs reported in LS are growth retardation, optic atrophy, ataxia, psychomotor retardation, dystonia, hypotonia, seizures and respiratory disorders. The paper reported a manifestation of 3 Tunisian patients presented with LS syndrome. The aim of this study is the MT[HYPHEN]ATP6 and SURF1 gene screening in Tunisian patients affected with classical Leigh syndrome and the computational investigation of the effect of detected mutations on its structure and functions by clinical and bioinformatics analyses. After clinical investigations, three Tunisian patients were tested for mutations in both MT-ATP6 and SURF1 genes by direct sequencing followed by in silico analyses to predict the effects of sequence variation. The result of mutational analysis revealed the absence of mitochondrial mutations in MT-ATP6 gene and the presence of a known homozygous splice site mutation c.516-517delAG in sibling patients added to the presence of a novel double het mutations in LS patient (c.752-18 A > C/c. c.751 + 16G > A). In silico analyses of theses intronic variations showed that it could alters splicing processes as well as SURF1 protein translation. Leigh syndrome (LS) is a rare progressive neurodegenerative disorder occurring in infancy. The most common clinical signs reported in LS are growth retardation, optic atrophy, ataxia, psychomotor retardation, dystonia, hypotonia, seizures and respiratory disorders. The paper reported a manifestation of 3 Tunisian patients presented with LS syndrome. The aim of this study is MT-ATP6 and SURF1 genes screening in Tunisian patients affected with classical Leigh syndrome and the computational investigation of the effect of detected mutations on its structure and functions. After clinical investigations, three Tunisian patients were tested for mutations in both MT-ATP6 and SURF1 genes by direct sequencing followed by in

  15. de Toni-Fanconi-Debré syndrome with Leigh syndrome revealing severe muscle cytochrome c oxidase deficiency

    NARCIS (Netherlands)

    Ogier, H.; Lombes, A.; Scholte, H. R.; Poll-The, B. T.; Fardeau, M.; Alcardi, J.; Vignes, B.; Niaudet, P.; Saudubray, J. M.

    1988-01-01

    We describe a patient with severe muscle cytochrome c oxidase deficiency who had de Toni-Fanconi-Debré syndrome and acute neurologic deterioration resembling Leigh syndrome, without clear evidence of muscle abnormality. Metabolic investigations revealed elevated cerebrospinal fluid lactate values

  16. Leigh syndrome associated with a deficiency of the pyruvate dehydrogenase complex: results of treatment with a ketogenic diet

    NARCIS (Netherlands)

    Wijburg, F. A.; Barth, P. G.; Bindoff, L. A.; Birch-Machin, M. A.; van der Blij, J. F.; Ruitenbeek, W.; TURNBULL, D. M.; Schutgens, R. B.

    1992-01-01

    A one-year-old boy suffering from intermittent lactic acidosis, muscular hypotonia, horizontal gaze paralysis and spasticity in both legs had low activity of the pyruvate dehydrogenase complex associated with low amounts of immunoreactive E 1 alpha and E 1 beta. Leigh syndrome was diagnosed on the

  17. A rapid screening with direct sequencing from blood samples for the diagnosis of Leigh syndrome

    Directory of Open Access Journals (Sweden)

    Hiroko Shimbo

    2014-01-01

    Full Text Available Large numbers of genes are responsible for Leigh syndrome (LS, making genetic confirmation of LS difficult. We screened our patients with LS using a limited set of 21 primers encompassing the frequently reported gene for the respiratory chain complexes I (ND1–ND6, and ND4L, IV(SURF1, and V(ATP6 and the pyruvate dehydrogenase E1α-subunit. Of 18 LS patients, we identified mutations in 11 patients, including 7 in mDNA (two with ATP6, 4 in nuclear (three with SURF1. Overall, we identified mutations in 61% of LS patients (11/18 individuals in this cohort. Sanger sequencing with our limited set of primers allowed us a rapid genetic confirmation of more than half of the LS patients and it appears to be efficient as a primary genetic screening in this cohort.

  18. [Leigh's encephalopathy (subacute necrotizing encephalopathy). Documentation of its evolution through neuroimaging].

    Science.gov (United States)

    Pena, J A; González-Ferrer, S; Martínez, C; Prieto-Carrasquero, M; Delgado, W; Mora La Cruz, E

    1996-09-01

    A 30 months-old boy developed bilateral nistagmus, tremor, gait disturbance, hypotonia and disartria. The diagnose of Leigh encephalopathy was suggested on the basis of clinical, neuroimaging and laboratory findings. Computed tomography and magnetic resonance imaging (MRI) at an early stage revealed bilateral and symmetric lesions in the putamen, appearing as hyperintense signal on T2-weighted images. Twelve months later a relatively large hypertense area in the posterior brainstem was observed. At this stage, the patient exhibited marked deterioration, dystonic manifestations, rigidity and respiratory disturbances. He died 6 months later for respiratory arrest during bronconeumonic infection. We believe MRI is a valuable means to allow assessment of the evolution of the disease.

  19. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.

    Science.gov (United States)

    Ferrari, Michele; Jain, Isha H; Goldberger, Olga; Rezoagli, Emanuele; Thoonen, Robrecht; Cheng, Kai-Hung; Sosnovik, David E; Scherrer-Crosbie, Marielle; Mootha, Vamsi K; Zapol, Warren M

    2017-05-23

    The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously breathing normobaric 11% O 2 from an early age prevents neurological disease and dramatically improves survival in these mice. Here, we report three advances. First, we report updated survival curves and organ pathology in Ndufs4 KO mice exposed to hypoxia or hyperoxia. Whereas normoxia-treated KO mice die from neurodegeneration at about 60 d, hypoxia-treated mice eventually die at about 270 d, likely from cardiac disease, and hyperoxia-treated mice die within days from acute pulmonary edema. Second, we report that more conservative hypoxia regimens, such as continuous normobaric 17% O 2 or intermittent hypoxia, are ineffective in preventing neuropathology. Finally, we show that breathing normobaric 11% O 2 in mice with late-stage encephalopathy reverses their established neurological disease, evidenced by improved behavior, circulating disease biomarkers, and survival rates. Importantly, the pathognomonic MRI brain lesions and neurohistopathologic findings are reversed after 4 wk of hypoxia. Upon return to normoxia, Ndufs4 KO mice die within days. Future work is required to determine if hypoxia can be used to prevent and reverse neurodegeneration in other animal models, and to determine if it can be provided in a safe and practical manner to allow in-hospital human therapeutic trials.

  20. Mito-nuclear Interactions Affecting Lifespan and Neurodegeneration in aDrosophilaModel of Leigh Syndrome.

    Science.gov (United States)

    Loewen, Carin A; Ganetzky, Barry

    2018-03-01

    Proper mitochondrial activity depends upon proteins encoded by genes in the nuclear and mitochondrial genomes that must interact functionally and physically in a precisely coordinated manner. Consequently, mito-nuclear allelic interactions are thought to be of crucial importance on an evolutionary scale, as well as for manifestation of essential biological phenotypes, including those directly relevant to human disease. Nonetheless, detailed molecular understanding of mito-nuclear interactions is still lacking, and definitive examples of such interactions in vivo are sparse. Here we describe the characterization of a mutation in Drosophila ND23 , a nuclear gene encoding a highly conserved subunit of mitochondrial complex 1. This characterization led to the discovery of a mito-nuclear interaction that affects the ND23 mutant phenotype. ND23 mutants exhibit reduced lifespan, neurodegeneration, abnormal mitochondrial morphology and decreased ATP levels. These phenotypes are similar to those observed in patients with Leigh Syndrome, which is caused by mutations in a number of nuclear genes that encode mitochondrial proteins, including the human ortholog of ND23 A key feature of Leigh Syndrome, and other mitochondrial disorders, is unexpected and unexplained phenotypic variability. We discovered that the phenotypic severity of ND23 mutations varies depending on the maternally inherited mitochondrial background. Sequence analysis of the relevant mitochondrial genomes identified several variants that are likely candidates for the phenotypic interaction with mutant ND23 , including a variant affecting a mitochondrially-encoded component of complex I. Thus, our work provides an in vivo demonstration of the phenotypic importance of mito-nuclear interactions in the context of mitochondrial disease. Copyright © 2018, Genetics.

  1. Miller Fisher syndrome presenting as palate paralysis.

    Science.gov (United States)

    Noureldine, Mohammad Hassan A; Sweid, Ahmad; Ahdab, Rechdi

    2016-09-15

    We report a 63-year old patient who presented to our care initially with a hypernasal voice followed by ataxia, ptosis, dysphonia, and paresthesias. The patient's history, physical examination, and additional tests led to a Miller Fisher syndrome (MFS) diagnosis. Palatal paralysis as an inaugurating manifestation of MFS is quite rare and requires special attention from neurologists and otolaryngologists. Although it may present as benign as an acute change in voice, early diagnosis and prompt management may prevent further complications. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Leigh-type neuropathology in Pearson syndrome associated with impaired ATP production and a novel mtDNA deletion.

    Science.gov (United States)

    Santorelli, F M; Barmada, M A; Pons, R; Zhang, L L; DiMauro, S

    1996-11-01

    Pearson syndrome is a systemic disorder of oxidative phosphorylation in infants, predominantly affecting the bone marrow and exocrine pancreas and associated with single deletions in mitochondrial DNA (mtDNA). CNS involvement may occur in patients who survive the infantile hematopoietic disorder. We describe a Pearson syndrome patient who developed neurologic manifestations associated with the pathologic features of Leigh syndrome. Biochemical studies in muscle and skin fibroblasts showed partial deficiencies of complexes I and IV of the respiratory chain. Adenosine triphosphate production in mitochondria isolated from skin fibroblasts was reduced to 25% of controls. We detected a novel 3.6 Kb mtDNA deletion in skin fibroblasts from the proband but not in his mother's white blood cells. Leigh syndrome seems to be the common neuropathologic expression of any disorder causing severe impairment of oxidative energy production in the CNS.

  3. Novel LRPPRC Mutation in a Boy With Mild Leigh Syndrome, French-Canadian Type Outside of Québec.

    Science.gov (United States)

    Han, Velda Xinying; Tan, Teresa S; Wang, Furene S; Tay, Stacey Kiat-Hong

    2017-01-01

    Leigh syndrome, French-Canadian type is unique to patients from a genetic isolate in the Saguenay-Lac-Saint-Jean region of Québec. It has also been recently described in 10 patients with LRPPRC mutation outside of Québec. It is an autosomal recessive genetic disorder with fatal metabolic crisis and severe neurological morbidity in infancy caused by LRPPRC mutation. The authors report a boy with a novel LRPPRC compound heterozygous missense mutations c.3130C>T, c.3430C>T, and c.4078G>A found on whole-exome sequencing which correlated with isolated cytochrome c-oxidase deficiency found in skeletal muscle. LRPPRC mutation is a rare cause of cytochrome c-oxidase-deficient form of Leigh syndrome outside of Québec. Our patient broadens the spectrum of phenotypes of Leigh syndrome, French-Canadian type. LRPPRC mutation should be considered in children with early childhood neurodegenerative disorder, even in the absence of metabolic crisis. Early evaluation with whole-exome sequencing is useful for early diagnosis and for genetic counseling.

  4. Unilateral external ophthalmoplegia in Miller Fisher syndrome: case report

    Directory of Open Access Journals (Sweden)

    Severn Philip

    2007-04-01

    Full Text Available Abstract Background A description of the diagnostic features of Miller Fisher syndrome. Case presentation The clinical presentation, investigation, and subsequent progress of our patient with clinical unilateral external ophthalmoplegia. Conclusion Our case demonstrates the presentation of clinical unilateral external ophthalmoplegia as part of the full triad of Miller Fisher syndrome.

  5. Miller Fisher syndrome with sinus arrest

    Directory of Open Access Journals (Sweden)

    Nobuko Shiraiwa

    2017-08-01

    Full Text Available Dysautonomia in Guillain-Barre syndrome (GBS rarely causes serious cardiovascular complications, such as sinus arrest. Miller Fisher syndrome (MFS is recognized as a variant of GBS. There have been few reports regarding the association between MFS and dysautonomia. We describe a case of a 68-year-old man with ophthalmoplegia, bulbar palsy, truncal ataxia, and areflexia. He was diagnosed with MFS because he exhibited the classical clinical triad and had elevated serum anti- GQ1b immunoglobulin G levels. A magnetic resonance imaging scan of his head was normal. His 24-hour Holter recording showed sinus arrest. He was treated with intravenous immunoglobulin, whereupon his symptoms gradually improved. This included the sinus arrest, which was considered a symptom of dysautonomia in MFS. Therefore, clinicians should be mindful of dysautonomia not only in GBS patients, but also in cases of MFS.

  6. A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

    Science.gov (United States)

    Thompson Legault, Julie; Strittmatter, Laura; Tardif, Jessica; Sharma, Rohit; Tremblay-Vaillancourt, Vanessa; Aubut, Chantale; Boucher, Gabrielle; Clish, Clary B; Cyr, Denis; Daneault, Caroline; Waters, Paula J; Vachon, Luc; Morin, Charles; Laprise, Catherine; Rioux, John D; Mootha, Vamsi K; Des Rosiers, Christine

    2015-11-03

    A decline in mitochondrial respiration represents the root cause of a large number of inborn errors of metabolism. It is also associated with common age-associated diseases and the aging process. To gain insight into the systemic, biochemical consequences of respiratory chain dysfunction, we performed a case-control, prospective metabolic profiling study in a genetically homogenous cohort of patients with Leigh syndrome French Canadian variant, a mitochondrial respiratory chain disease due to loss-of-function mutations in LRPPRC. We discovered 45 plasma and urinary analytes discriminating patients from controls, including classic markers of mitochondrial metabolic dysfunction (lactate and acylcarnitines), as well as unexpected markers of cardiometabolic risk (insulin and adiponectin), amino acid catabolism linked to NADH status (α-hydroxybutyrate), and NAD(+) biosynthesis (kynurenine and 3-hydroxyanthranilic acid). Our study identifies systemic, metabolic pathway derangements that can lie downstream of primary mitochondrial lesions, with implications for understanding how the organelle contributes to rare and common diseases. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Mitochondrial DNA deletion in a patient with combined features of Leigh and Pearson syndromes

    Energy Technology Data Exchange (ETDEWEB)

    Blok, R.B.; Thorburn, D.R.; Danks, D.M. [Royal Children`s Hospital, Melbourne (Australia)] [and others

    1994-09-01

    We describe a heteroplasmic 4237 bp mitochondrial DNA (mtDNA) deletion in an 11 year old girl who has suffered from progressive illness since birth. She has some features of Leigh syndrome (global developmental delay with regression, brainstem dysfunction and lactic acidosis), together with other features suggestive of Pearson syndrome (history of pancytopenia and failure to thrive). The deletion was present at a level greater than 50% in skeletal muscle, but barely detectable in skin fibroblasts following Southern blot analysis, and only observed in blood following PCR analysis. The deletion spanned nt 9498 to nt 13734, and was flanked by a 12 bp direct repeat. Genes for cytochrome c oxidase subunit III, NADH dehydrogenase subunits 3, 4L, 4 and 5, and tRNAs for glycine, arginine, histidine, serine({sup AGY}) and leucine({sup CUN}) were deleted. Southern blotting also revealed an altered Apa I restriction site which was shown by sequence analysis to be caused by G{r_arrow}A nucleotide substitution at nt 1462 in the 12S rRNA gene. This was presumed to be a polymorphism. No abnormalities of mitochondrial ultrastructure, distribution or of respiratory chain enzyme complexes I-IV in skeletal muscle were observed. Mitochondrial disorders with clinical features overlapping more than one syndrome have been reported previously. This case further demonstrates the difficulty in correlating observed clinical features with a specific mitochondrial DNA mutation.

  8. NOAA Ship Miller Freeman Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Miller Freeman Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic System...

  9. The Miller Revival (1831-1844): Waiting for Christ Return...

    OpenAIRE

    Fábio Augusto Darius

    2014-01-01

    The Baptist farmer William Miller, in solitary study — equipped with Cruden’s Concordance and his King James Bible — started a great movement of revival in the United States. According to their calculations, Christ literally returns in the sky between March 1843 and March 1844. Great was the disappointment of their fans when the expected does not happen. The article discusses the concepts of Miller on the books of Daniel and Revelation, key to understanding the historical ev...

  10. Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome.

    Science.gov (United States)

    Sasarman, Florin; Nishimura, Tamiko; Antonicka, Hana; Weraarpachai, Woranontee; Shoubridge, Eric A

    2015-01-15

    French Canadian Leigh Syndrome (LSFC) is an early-onset, progressive neurodegenerative disorder with a distinct pattern of tissue involvement. Most cases are caused by a founder missense mutation in LRPPRC. LRPPRC forms a ribonucleoprotein complex with SLIRP, another RNA-binding protein, and this stabilizes polyadenylated mitochondrial mRNAs. LSFC fibroblasts have reduced levels of LRPPRC and a specific complex IV assembly defect; however, further depletion of mutant LRPPRC results in a complete failure to assemble a functional oxidative phosphorylation system, suggesting that LRPPRC levels determine the nature of the biochemical phenotype. We tested this hypothesis in cultured muscle cells and tissues from LSFC patients. LRPPRC levels were reduced in LSFC muscle cells, resulting in combined complex I and IV deficiencies. A similar combined deficiency was observed in skeletal muscle. Complex IV was only moderately reduced in LSFC heart, but was almost undetectable in liver. Both of these tissues showed elevated levels of complexes I and III. Despite the marked biochemical differences, the steady-state levels of LRPPRC and mitochondrial mRNAs were extremely low, LRPPRC was largely detergent-insoluble, and SLIRP was undetectable in all LSFC tissues. The level of the LRPPRC/SLIRP complex appeared much reduced in control tissues by the first dimension blue-native polyacrylamide gel electrophoresis (BN-PAGE) analysis compared with fibroblasts, and even by second dimension analysis it was virtually undetectable in control heart. These results point to tissue-specific pathways for the post-transcriptional handling of mitochondrial mRNAs and suggest that the biochemical defects in LSFC reflect the differential ability of tissues to adapt to the mutation. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. The mitochondrial DNA 10197 G > A mutation causes MELAS/Leigh overlap syndrome presenting with acute auditory agnosia.

    Science.gov (United States)

    Leng, Yinglin; Liu, Yuhe; Fang, Xiaojing; Li, Yao; Yu, Lei; Yuan, Yun; Wang, Zhaoxia

    2015-04-01

    Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes/Leigh (MELAS/LS) overlap syndrome is a mitochondrial disorder subtype with clinical and magnetic resonance imaging (MRI) features that are characteristic of both MELAS and Leigh syndrome (LS). Here, we report an MELAS/LS case presenting with cortical deafness and seizures. Cranial MRI revealed multiple lesions involving bilateral temporal lobes, the basal ganglia and the brainstem, which conformed to neuroimaging features of both MELAS and LS. Whole mitochondrial DNA (mtDNA) sequencing and PCR-RFLP revealed a de novo heteroplasmic m.10197 G > A mutation in the NADH dehydrogenase subunit 3 gene (ND3), which was predicted to cause an alanine to threonine substitution at amino acid 47. Although the mtDNA m.10197 G > A mutation has been reported in association with LS, Leber hereditary optic neuropathy and dystonia, it has never been linked with MELAS/LS overlap syndrome. Our patient therefore expands the phenotypic spectrum of the mtDNA m.10197 G > A mutation.

  12. Exome sequencing reveals a novel Moroccan founder mutation in SLC19A3 as a new cause of early-childhood fatal Leigh syndrome.

    Science.gov (United States)

    Gerards, Mike; Kamps, Rick; van Oevelen, Jo; Boesten, Iris; Jongen, Eveline; de Koning, Bart; Scholte, Hans R; de Angst, Isabel; Schoonderwoerd, Kees; Sefiani, Abdelaziz; Ratbi, Ilham; Coppieters, Wouter; Karim, Latifa; de Coo, René; van den Bosch, Bianca; Smeets, Hubert

    2013-03-01

    Leigh syndrome is an early onset, often fatal progressive neurodegenerative disorder caused by mutations in the mitochondrial or nuclear DNA. Until now, mutations in more than 35 genes have been reported to cause Leigh syndrome, indicating an extreme genetic heterogeneity for this disorder, but still only explaining part of the cases. The possibility of whole exome sequencing enables not only mutation detection in known candidate genes, but also the identification of new genes associated with Leigh syndrome in small families and isolated cases. Exome sequencing was combined with homozygosity mapping to identify the genetic defect in a Moroccan family with fatal Leigh syndrome in early childhood and specific magnetic resonance imaging abnormalities in the brain. We detected a homozygous nonsense mutation (c.20C>A; p.Ser7Ter) in the thiamine transporter SLC19A3. In vivo overexpression of wild-type SLC19A3 showed an increased thiamine uptake, whereas overexpression of mutant SLC19A3 did not, confirming that the mutation results in an absent or non-functional protein. Seventeen additional patients with Leigh syndrome were screened for mutations in SLC19A3 using conventional Sanger sequencing. Two unrelated patients, both from Moroccan origin and one from consanguineous parents, were homozygous for the same p.Ser7Ter mutation. One of these patients showed the same MRI abnormalities as the patients from the first family. Strikingly, patients receiving thiamine had an improved life-expectancy. One patient in the third family deteriorated upon interruption of the thiamine treatment and recovered after reinitiating. Although unrelated, all patients came from the province Al Hoceima in Northern Morocco. Based on the recombination events the mutation was estimated to have occurred 1250-1750 years ago. Our data shows that SLC19A3 is a new candidate for mutation screening in patients with Leigh syndrome, who might benefit from high doses of thiamine and/or biotin. Especially

  13. The numerical thermodynamic analysis of Otto-Miller Cycle (OMC

    Directory of Open Access Journals (Sweden)

    Cakir Mehmet

    2016-01-01

    Full Text Available This paper presents a thermodynamic analysis for an irreversible Otto-Miller Cycle (OMC by taking into consideration heat transfer effects and internal irreversibilities resulting from compression and expansion processes. In the analyses, the influences of the miller cycle ratio, combustion and heat loss constants and inlet temperature have been investigated relations with efficiency in dimensionless form. The dimensionless power output and power density and thermal efficiency relations have been computationally obtained versus the engine design parameters with respect to combustion and heat transfer constants. The results demonstrate that the heat transfer and combustion constants have considerable effects on the cycle thermodynamic performance. This situation theoretically verified for OMC.

  14. Statistical versus Musical Significance: Commentary on Leigh VanHandel's 'National Metrical Types in Nineteenth Century Art Song'

    Directory of Open Access Journals (Sweden)

    Justin London

    2010-01-01

    Full Text Available In “National Metrical Types in Nineteenth Century Art Song” Leigh Van Handel gives a sympathetic critique of William Rothstein’s claim that in western classical music of the late 18th and 19th centuries there are discernable differences in the phrasing and metrical practice of German versus French and Italian composers. This commentary (a examines just what Rothstein means in terms of his proposed metrical typology, (b questions Van Handel on how she has applied it to a purely melodic framework, (c amplifies Van Handel’s critique of Rothstein, and then (d concludes with a rumination on the reach of quantitative (i.e., statistically-driven versus qualitative claims regarding such things as “national metrical types.”

  15. Revision of the genus Chelonocoris miller (Hemiptera, Aradidae)

    NARCIS (Netherlands)

    Usinger, R.L.

    1954-01-01

    Apterous Aradidae were first brought to the attention of Hemipterists by N. C. E. Miller (Ann. Mag. Nat. Hist. [11] 1: 498-510, 1938). In fact it can be said that this paper with its excellent illustrations was the stimulus for the striking discoveries that have been made in this group in the past

  16. The effect of quince leaf ( Cydonia oblonga miller) decoction on ...

    African Journals Online (AJOL)

    Current medical literature lacks any evidence of the protective effects of quince leaf on testes. Therefore, the aim of the present study was to assess the effect of quince (Cydonia oblonga Miller) leaf decoction on testicular injury and impaired spermatogenesis induced by hypercholesterolemia in rabbits. Eleven mature New ...

  17. Successful di cult airway intubation using the Miller laryngoscope ...

    African Journals Online (AJOL)

    with the use of a Miller laryngoscope blade (straight blade) and paraglossal technique, achieving Cormack and Lehane views superior to those seen using Macintosh blades.7 As early as 1997,. Henderson8 questioned the role of curved blades for di cult airway intubation and proposed that paraglossal straight blade.

  18. Modigliani-Miller, Basel 3 and CRD 4

    DEFF Research Database (Denmark)

    Balling, Morten

    2015-01-01

    Since 2007, bank capital regulation has been strengthened in Europe and globally. Bank organizations have expressed serious concerns about the impact of higher capital requirements on bank funding costs adn on the lending capacity of banks. The message of a 1958-Article by Modigliani and Miller...

  19. Daily surface water temperature data collected from bucket casts from pier at Leigh Marine Laboratory, Auckland, New Zealand from 1967-01-01 to 2011-04-30 (NCEI Accession 0127323)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collected seawater temperatures at the Leigh Marine Laboratory. Dataset contains an archive of material to 2011. The location of the laboratory is lat: -36.26929,...

  20. Surface water temperature data collected from data logger at 1 meter from pier at Leigh Marine Laboratory, Auckland, New Zealand from 2011-07-10 to 2014-12-19 (NCEI Accession 0127341)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Seawater surface temperatures collected adjacent the Leigh Marine Laboratory. Hourly measurements are taken by means of an electronic data logger. The sensor is...

  1. Wentworth Miller : "Minu edu saladus? Kunstniku hing ja bürokraadi pulss" / Wentworth Miller ; koost. Triin Tael

    Index Scriptorium Estoniae

    Miller, Wentworth

    2006-01-01

    Cannes'is hotellis Carlton toimunud pressikonverentsist, kus ajakirjanike küsimustele vastasid põnevusseriaali "Põgenemine" peaosatäitjad Wentworth Miller ja Dominic Purcell. Lisaks "Wentworth SL Õhtulehele : "Minu südame võitmiseks tuleb oodata" ja tutvustus "Wentworthi läbimurdefilm täna õhtul ETVs"

  2. International risk and preceived environmental uncertainty: The dimentionality and internal consistency of Miller's measure

    NARCIS (Netherlands)

    Brouthers, K.D.

    1996-01-01

    Increasingly, scholars have suggested that there is a need to approach the problem of international risk from a multidimensional perspective [Brouthers 1995; Miller 1993; Shan 1991]. Miller [1992, 1993] developed and tested the most comprehensive framework to date. Miller [1993] showed high

  3. A new mutation in MT-ND1 m.3928G>C p.V208L causes Leigh disease with infantile spasms.

    Science.gov (United States)

    Wray, Carter D; Friederich, Marisa W; du Sart, Desiree; Pantaleo, Sarah; Smet, Joél; Kucera, Cathlin; Fenton, Laura; Scharer, Gunter; Van Coster, Rudy; Van Hove, Johan L K

    2013-11-01

    New mutations in mitochondrial DNA encoded genes of complex I are rarely reported. An infant developed Leigh disease with infantile spasms. Complex I enzyme activity was deficient and response to increasing coenzyme Q concentrations was reduced. Complex I assembly was intact. A new mutation in MT-ND1 m.3928G>C p.V208L, affecting a conserved amino acid in a critical domain, part of the coenzyme Q binding pocket, was present at high heteroplasmy. The unaffected mother did not carry measurable mutant mitochondrial DNA, but concern remained for gonadal mosaicism. Prenatal testing was possible for a subsequent sibling. The ND1 p.V208L mutation causes Leigh disease. © 2013.

  4. Lee Miller, une battante sur tous les fronts

    Directory of Open Access Journals (Sweden)

    Anaïs Boutot

    2009-06-01

    Full Text Available L’art photographique de Lee Miller, à l’image de sa vie, revêt de multiples facettes. Après avoir été devant l’objectif en tant que mannequin puis égérie du Paris surréaliste, elle passe derrière l’objectif pour devenir photographe de mode, reporter de guerre ou encore portraitiste. L’exposition L’Art de Lee Miller, présentée au Jeu de Paume du 21 octobre 2008 au 4 janvier 2009 et accompagnée d’un ouvrage paru en français chez Hazan mettait en avant une quête d’identité et d’indépendance qui ...

  5. Petrography and Geochemistry of Lunar Meteorite Miller Range 13317

    Science.gov (United States)

    Zeigler, R. A.; Korotev, R. L.

    2016-01-01

    Miller Range (MIL) 13317 is a 32-g lunar meteorite collected during the 2013-2014 ANSMET (Antarctic Search for Meteorites) field season. It was initially described as having 25% black fusion crust covering a light- to dark-grey matrix, with numerous clasts ranging in size up to 1 cm; it was tenta-tively classified as a lunar anorthositic breccia. Here we present the petrography and geochemistry of MIL 13317, and examine possible pairing relationships with previously described lunar meteorites.

  6. Controversies and challenges of vaccination: an interview with Elizabeth Miller

    OpenAIRE

    Miller, Elizabeth

    2015-01-01

    Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine refusers and hesitators, the resulting health consequences, and ways in which health professionals and industry regulators can help promote transparency to better convey the sub...

  7. Controversies and challenges of vaccination: an interview with Elizabeth Miller.

    Science.gov (United States)

    Miller, Elizabeth

    2015-10-16

    Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine refusers and hesitators, the resulting health consequences, and ways in which health professionals and industry regulators can help promote transparency to better convey the substantial health benefits of vaccination.

  8. First mortality analysis in the French cohort of uranium millers (F-Millers), period 1968-2013.

    Science.gov (United States)

    Bouet, Ségolène; Samson, Eric; Jovanovic, Iris; Laurier, Dominique; Laurent, Olivier

    2018-01-01

    Epidemiological studies in cohorts of uranium millers can be informative to improve knowledge of the health effects of uranium, but are very rare. The aim of this study was to analyze, for the first time, mortality in a French cohort of uranium millers. The F-Millers cohort includes permanent contract workers employed at least 6 months at French uranium milling plants. Vital status and causes of death were obtained from national registries between 1968 and 2013, in order to perform comparisons with French national and local mortality rates by computing standardized mortality ratios (SMRs) with 95% confidence intervals (95% CI). The cohort includes 1291 workers. The average duration of follow-up is 32.1 years. At the end of follow-up, 448 workers were deceased and 13 lost to follow-up. We observed a significant deficit of mortality for all causes combined when the national reference was considered (SMR 0.81; 95% CI [0.74;0.89]), but no significant difference when the local reference was considered (SMR 0.97; 95% CI [0.88;1.07]). Significant excesses were observed only in a subgroup of 552 workers hired at the manufacturing unit, mainly when the local reference was considered. No significant excess of mortality was observed at the scale of the full cohort. The cause-specific excesses of mortality observed in the subgroup of workers hired at the manufacturing unit were based on small number of cases, but would warrant further investigations. Undertaking analytical studies and combined analyses of cohorts of uranium millers would help to study the influence of potential risk factors and obtain more precise results.

  9. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.

    Science.gov (United States)

    Janer, Alexandre; Prudent, Julien; Paupe, Vincent; Fahiminiya, Somayyeh; Majewski, Jacek; Sgarioto, Nicolas; Des Rosiers, Christine; Forest, Anik; Lin, Zhen-Yuan; Gingras, Anne-Claude; Mitchell, Grant; McBride, Heidi M; Shoubridge, Eric A

    2016-09-01

    Mitochondria form a dynamic network that responds to physiological signals and metabolic stresses by altering the balance between fusion and fission. Mitochondrial fusion is orchestrated by conserved GTPases MFN1/2 and OPA1, a process coordinated in yeast by Ugo1, a mitochondrial metabolite carrier family protein. We uncovered a homozygous missense mutation in SLC25A46, the mammalian orthologue of Ugo1, in a subject with Leigh syndrome. SLC25A46 is an integral outer membrane protein that interacts with MFN2, OPA1, and the mitochondrial contact site and cristae organizing system (MICOS) complex. The subject mutation destabilizes the protein, leading to mitochondrial hyperfusion, alterations in endoplasmic reticulum (ER) morphology, impaired cellular respiration, and premature cellular senescence. The MICOS complex is disrupted in subject fibroblasts, resulting in strikingly abnormal mitochondrial architecture, with markedly shortened cristae. SLC25A46 also interacts with the ER membrane protein complex EMC, and phospholipid composition is altered in subject mitochondria. These results show that SLC25A46 plays a role in a mitochondrial/ER pathway that facilitates lipid transfer, and link altered mitochondrial dynamics to early-onset neurodegenerative disease and cell fate decisions. © 2016 The Authors. Published under the terms of the CC BY 4.0 license.

  10. A Case of Neuromyelitis Optica Masquerading as Miller Fisher Syndrome

    Directory of Open Access Journals (Sweden)

    Yuka Furutani

    2014-10-01

    Full Text Available A 22-year-old woman presented with double vision that she had experienced since an infection 2 weeks previously. A neurological examination showed limited bilateral eye abduction, mimicking Miller Fisher syndrome. However, T2-weighted magnetic resonance imaging of her brain revealed hyperintense areas in the tegmentum of the pons, including the abducens nucleus, and her serum anti-aquaporin-4 antibody test was positive. She was finally diagnosed with neuromyelitis optica. Intravenous high-dose steroid therapy immediately improved the patient's abduction palsy, but bilateral optic neuritis manifested during the treatment. Subsequent treatment with plasma exchange improved her optic neuritis symptoms.

  11. Prime Number: an Experiment Rabin-Miller and Fast Exponentiation

    Science.gov (United States)

    Rahim, Robbi; Winata, Hendryan; Zulkarnain, Iskandar; Jaya, Hendra

    2017-12-01

    Prime number is one of the most widely used names for various security purposes, especially in the process of encryption and decryption for asymmetric algorithms, the speed in determining prime number becomes one of the most important things, Rabin-Miller algorithm is used to test a number whether including prime or not, speed in determining prime number is very important and technique that could be using is fast exponentiation, this research get significant result in testing prime number with length of variation number.

  12. A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?

    OpenAIRE

    Salehi, Nooshin; Choi, Eric D.; Garrison, Roger C.

    2017-01-01

    Patient: Male, 32 Final Diagnosis: Miller Fisher syndrome Symptoms: Ataxia ? headache ? ophthalmoplegia Medication: ? Clinical Procedure: Plasmapheresis Specialty: Neurology Objective: Rare co-existance of disease or pathology Background: Miller Fisher Syndrome is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia, and is considered to be a variant of Guillain-Barre Syndrome. Miller Fisher Syndrome is observed in approximately 1?5% of all Guillain-Barre cases in Wes...

  13. 'The Right Time and the Right Place': An Interview with Jacques Miller.

    Science.gov (United States)

    Anderson, Warwick

    2016-01-01

    Professor Jacques F.P. Miller spoke about his career in immunology with Warwick Anderson on 3 February 2014. Born in Nice, France, Miller attended high school and medical school in Sydney, Australia. As a Ph.D. student and postgraduate researcher in London, Miller discovered the immunological function of the thymus gland. Spending the rest of his career at the Walter and Eliza Hall Institute for Medical Research in Melbourne, Miller conducted pioneering research in lymphocyte population dynamics and the mechanisms of the human immune response. With Graham Mitchell, he demonstrated that mammalian lymphocytes can be divided into what became known as T cells and B cells, which interact to produce antibodies.

  14. Abordagem anestésica em paciente pediátrico com síndrome de Leigh

    Directory of Open Access Journals (Sweden)

    Ismail Serhat Kocamanoglu

    2013-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A síndrome de Leigh (SL é uma doença rara causada por anomalias na produção de energia mitocondrial. O sistema nervoso central é afetado com mais frequência, com retardo psicomotor, convulsões, nistagmo, oftalmoparesia, atrofia óptica, ataxia, distonia ou insuficiência respiratória. Os procedimentos cirúrgicos e anestésicos provocam irritabilidade traqueal e podem exacerbar os riscos de aspiração, sibilação, dificuldade respiratória, respiração ofegante, hipoventilação e apneia. RELATO DE CASO: Apresentamos uma abordagem anestésica usada em um menino de seis anos com a forma grave de SL que envolve reparação de uma fratura de fêmur. Propofol e remifentanil foram infundidos para anestesia geral. O paciente foi atentamente monitorado durante a anestesia e sua permanência na unidade de terapia intensiva no período pós-operatório inicial. CONCLUSÕES: Uma atenta monitoração intraoperatória dos pacientes, que inclui pressão arterial invasiva e mensurações frequentes da gasometria, glicose e lactato, faz esse procedimento transcorrer sem problemas. A terapia intensiva e a assistência respiratória ao paciente com SL sob sedação, com uma combinação de analgésicos durante o período pós-operatório inicial, minimizaram a resposta ao estresse causado pela dor pós-cirúrgica.

  15. Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients.

    Science.gov (United States)

    Burelle, Yan; Bemeur, Chantal; Rivard, Marie-Eve; Thompson Legault, Julie; Boucher, Gabrielle; Morin, Charles; Coderre, Lise; Des Rosiers, Christine

    2015-01-01

    Mutations in LRPPRC are responsible for the French Canadian variant of Leigh Syndrome (LSFC), a severe disorder characterized biochemically by a tissue-specific deficiency of cytochrome c oxidase (COX) and clinically by the occurrence of severe and deadly acidotic crises. Factors that precipitate these crises remain unclear. To better understand the physiopathology and identify potential treatments, we performed a comprehensive analysis of mitochondrial function in LSFC and control fibroblasts. Furthermore, we have used this cell-based model to screen for conditions that promote premature cell death in LSFC cells and test the protective effect of ten interventions targeting well-defined aspects of mitochondrial function. We show that, despite maintaining normal ATP levels, LSFC fibroblasts present several mitochondrial functional abnormalities under normal baseline conditions, which likely impair their capacity to respond to stress. This includes mitochondrial network fragmentation, impaired oxidative phosphorylation capacity, lower membrane potential, increased sensitivity to Ca2+-induced permeability transition, but no changes in reactive oxygen species production. We also show that LSFC fibroblasts display enhanced susceptibility to cell death when exposed to palmitate, an effect that is potentiated by high lactate, while high glucose or acidosis alone or in combination were neutral. Furthermore, we demonstrate that compounds that are known to promote flux through the electron transport chain independent of phosphorylation (methylene blue, dinitrophenol), or modulate fatty acid (L-carnitine) or Krebs cycle metabolism (propionate) are protective, while antioxidants (idebenone, N-acetyl cysteine, resveratrol) exacerbate palmitate plus lactate-induced cell death. Collectively, beyond highlighting multiple alterations in mitochondrial function and increased susceptibility to nutrient-induced cytotoxicity in LSFC fibroblasts, these results raise questions about the

  16. Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients.

    Directory of Open Access Journals (Sweden)

    Yan Burelle

    Full Text Available Mutations in LRPPRC are responsible for the French Canadian variant of Leigh Syndrome (LSFC, a severe disorder characterized biochemically by a tissue-specific deficiency of cytochrome c oxidase (COX and clinically by the occurrence of severe and deadly acidotic crises. Factors that precipitate these crises remain unclear. To better understand the physiopathology and identify potential treatments, we performed a comprehensive analysis of mitochondrial function in LSFC and control fibroblasts. Furthermore, we have used this cell-based model to screen for conditions that promote premature cell death in LSFC cells and test the protective effect of ten interventions targeting well-defined aspects of mitochondrial function. We show that, despite maintaining normal ATP levels, LSFC fibroblasts present several mitochondrial functional abnormalities under normal baseline conditions, which likely impair their capacity to respond to stress. This includes mitochondrial network fragmentation, impaired oxidative phosphorylation capacity, lower membrane potential, increased sensitivity to Ca2+-induced permeability transition, but no changes in reactive oxygen species production. We also show that LSFC fibroblasts display enhanced susceptibility to cell death when exposed to palmitate, an effect that is potentiated by high lactate, while high glucose or acidosis alone or in combination were neutral. Furthermore, we demonstrate that compounds that are known to promote flux through the electron transport chain independent of phosphorylation (methylene blue, dinitrophenol, or modulate fatty acid (L-carnitine or Krebs cycle metabolism (propionate are protective, while antioxidants (idebenone, N-acetyl cysteine, resveratrol exacerbate palmitate plus lactate-induced cell death. Collectively, beyond highlighting multiple alterations in mitochondrial function and increased susceptibility to nutrient-induced cytotoxicity in LSFC fibroblasts, these results raise

  17. Effect of the Miller cycle on the performance of turbocharged hydrogen internal combustion engines

    International Nuclear Information System (INIS)

    Luo, Qing-he; Sun, Bai-gang

    2016-01-01

    Highlights: • The Miller cycle can increase power density for turbocharged hydrogen engines. • The boundaries is limited by the turbocharged system and valve lift. • Broke power and BSFC of using Miller cycle is the best in three technical methods. - Abstract: Hydrogen is a promising energy carrier, and the port fuel injection (PFI) is a fuel-flexible, durable, and relatively cheap method of energy conversion. However, the contradiction of increasing the power density and controlling NOx emissions limits the wide application of PFI hydrogen internal combustion engines. To address this issue, two typical thermodynamic cycles—the Miller and Otto cycles—are studied based on the calculation model proposed in this study. The thermodynamic cycle analyses of the two cycles are compared and results show that the thermal efficiency of the Miller cycle (η Miller ) is higher than η Otto , when the multiplied result of the inlet pressure and Miller cycle coefficient (δ M γ M ) is larger than that of the Otto cycle (i.e., the value of the inlet pressure ratio multiplied by the Miller cycle coefficient is larger than the value of the inlet pressure ratio of the Otto cycle). The results also show that the intake valve closure (IVC) of the Miller cycle is limited by the inlet pressure and valve lift. The two factors show the boundaries of the Miller cycle in increasing the power density of the turbocharged PFI hydrogen engine. The ways of lean burn + Otto cycle (LO), stoichiometric equivalence ratio burn + EGR + Otto cycle (SEO) and Miller cycle in turbocharged hydrogen engine are compared, the results show that the Miller cycle has the highest power density and the lowest BSFC among the three methods at an engine speed of 2800 rpm and NOx emissions below 100 ppm. The brake power of the Miller cycle increases by 37.7% higher than that of the LO and 26.3% higher than that of SEO, when γ M is 0.7. The BSFC of the Miller cycle decreases by 16% lower than that of the LO

  18. TRABAJO SEXUAL Y FEMINISMO, UNA FILIACIÓN BORRADA: TRADUCCIÓN DE "INVENTING SEX WORK" DE CAROL LEIGH (ALIAS SCARLOT HARLOT

    Directory of Open Access Journals (Sweden)

    Santiago Morcillo

    2016-01-01

    Full Text Available En esta introducción a la traducción del texto de Carol Leigh, reponemos brevemente el contexto de los debates feministas presentes en el surgimiento de la idea de trabajo sexual. Además brindamos una clave de lectura que permite comprender la importancia actual de esta traducción en el marco de una fuerte polarización del debate feminista sobre la prostitución y la transnacionalización de la campaña contra la trata de personas.

  19. Legitimizing Technical Communication in English Departments: Carolyn Miller's "Humanistic Rationale for Technical Writing"

    Science.gov (United States)

    Moore, Patrick

    2006-01-01

    Carolyn Miller's oft-cited "Humanistic Rationale for Technical Writing," published in 1979, tries to give technical communication faculty more cultural capital in English departments controlled by literature professors. Miller replaces a positivistic emphasis in technical communication pedagogy with rhetoric. She shows how technical knowledge is…

  20. Maslow and Miller: An Exploration of Gender and Affiliation in the Journey to Competence

    Science.gov (United States)

    Coy, Doris Rhea; Kovacs-Long, Judith

    2005-01-01

    This article shows that although neither Abraham Maslow nor Jean Baker Miller reference each other in their writings, they are following different paths to the same conclusion: competence proceeds from connection. Miller and Maslow both describe a developmental model that applies equally to women and men. The conclusion of the authors of this…

  1. Miller Creek Demonstration Forest ecology activities - a teachers supplement to the field guide

    Science.gov (United States)

    Bill Schustrom; Reed Kuennen; Raymond C. Shearer

    1998-01-01

    Miller Creek, on the Flathead National Forest in northwestern Montana, is a demonstration forest, showing up to 30 years of forest change. This teachers supplement to the educational field guide (Miller Creek Demonstration Forest - a forest born of fire: a field guide; Gen. Tech. Rep. RMRS-GTR-7, 1998) outlines eight field and classroom activities that teach students a...

  2. Hamilton's Marbles or Jevon's Beans: A Demonstration of Miller's Magical Number Seven.

    Science.gov (United States)

    Shaffer, Leigh S.

    1982-01-01

    Describes a demonstration for college-level cognitive psychology classes of Miller's "Magical Number Seven" concept of the limitation of sensory capacity for processing information. Students report on the number of pennies they observed in a box after viewing the coins for two seconds. Demonstration results consistently support Miller's…

  3. Investigating the Skoog-Miller Model for Organogenesis Using Sweet Potato Root Explants.

    Science.gov (United States)

    Delany, William; And Others

    1994-01-01

    Describes an experiment in which groups of students in a plant tissue culture course worked together to test application of the Skoog-Miller model (developed by Skoog and Miller in regeneration of tobacco experiments to demonstrate organogenesis) to sweet potato root explants. (ZWH)

  4. Abordagem anestésica em paciente pediátrico com síndrome de Leigh Abordaje anestésico en paciente Pediátrico con el síndrome de Leigh Anesthetic management of a pediatric patient with Leigh syndrome

    Directory of Open Access Journals (Sweden)

    Ismail Serhat Kocamanoglu

    2013-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A síndrome de Leigh (SL é uma doença rara causada por anomalias na produção de energia mitocondrial. O sistema nervoso central é afetado com mais frequência, com retardo psicomotor, convulsões, nistagmo, oftalmoparesia, atrofia óptica, ataxia, distonia ou insuficiência respiratória. Os procedimentos cirúrgicos e anestésicos provocam irritabilidade traqueal e podem exacerbar os riscos de aspiração, sibilação, dificuldade respiratória, respiração ofegante, hipoventilação e apneia. RELATO DE CASO: Apresentamos uma abordagem anestésica usada em um menino de seis anos com a forma grave de SL que envolve reparação de uma fratura de fêmur. Propofol e remifentanil foram infundidos para anestesia geral. O paciente foi atentamente monitorado durante a anestesia e sua permanência na unidade de terapia intensiva no período pós-operatório inicial. CONCLUSÕES: Uma atenta monitoração intraoperatória dos pacientes, que inclui pressão arterial invasiva e mensurações frequentes da gasometria, glicose e lactato, faz esse procedimento transcorrer sem problemas. A terapia intensiva e a assistência respiratória ao paciente com SL sob sedação, com uma combinação de analgésicos durante o período pós-operatório inicial, minimizaram a resposta ao estresse causado pela dor pós-cirúrgica.JUSTIFICATIVA Y OBJETIVOS: El síndrome de Leigh (SL es una enfermedad rara causada por anomalías en la producción de energía mitocondrial. El sistema nervioso central está afectado más a menudo, con el retardo psicomotor, convulsiones, nistagmo, oftalmoparesia, atrofia óptica, ataxia, distonía o insuficiencia respiratoria. Los procedimientos quirúrgicos y anestésicos provocan irritabilidad traqueal y pueden exacerbar los riesgos de aspiración, sibilancias, dificultad respiratoria, respiración extenuante, hipoventilación y apnea. RELATO DE CASO: Presentamos un abordaje anestésico usado en un niño de 6

  5. Karp-Miller Trees for a Branching Extension of VASS

    Directory of Open Access Journals (Sweden)

    Kumar Neeraj Verma

    2005-12-01

    Full Text Available We study BVASS (Branching VASS which extend VASS (Vector Addition Systems with States by allowing addition transitions that merge two configurations. Runs in BVASS are tree-like structures instead of linear ones as for VASS. We show that the construction of Karp-Miller trees for VASS can be extended to BVASS. This entails that the coverability set for BVASS is computable. This allows us to obtain decidability results for certain classes of equational tree automata with an associative-commutative symbol. Recent independent work by de Groote et al. implies that decidability of reachability in BVASS is equivalent to decidability of provability in MELL (multiplicative exponential linear logic, which is still an open problem. Hence our results are also a step towards answering this question in the affirmative.

  6. Clinical Features of Miller-Fisher Syndrome in Pregnancy

    Directory of Open Access Journals (Sweden)

    Masanori Ono

    2015-01-01

    Full Text Available Miller-Fisher syndrome (MFS is recognized as a variant of Guillain-Barré syndrome (GBS. MFS is a rare disorder that is characterized by the acute onset of ophthalmoplegia, ataxia, and areflexia/hyporeflexia. MFS has a higher incidence in Asia, where the incidence is estimated to be 18%–26% of GBS compared with 3%–5% in the West. The differential diagnosis of MFS includes Wernicke’s encephalopathy (WE which is characterized by a clinical triad (nystagmus and ophthalmoplegia, mental status changes, and ataxia, myasthenia gravis, and brainstem stroke. The association between MFS and pregnancy has not been reported previously. Here, we describe the clinical features of a pregnant woman in early pregnancy with MFS. This case highlights the fact that it is necessary to establish an accurate diagnosis based on the details from the patient’s history on appropriate complementary testing in a pregnant patient with MFS.

  7. Biofunctional properties of Eruca sativa Miller (rocket salad) hydroalcoholic extract.

    Science.gov (United States)

    Sultan, Khushbakht; Zakir, Muhammad; Khan, Haroon; Rauf, Abdur; Akber, Noor Ul; Khan, Murad Ali

    2016-01-01

    Eruca sativa Miller is a worldwide common alimentary plant (rocket leaves). The aim of this study was to correlate the potential in vitro scavenging activity of the E. sativa hydroalcoholic extract (HAE) with its in vivo hypoglycaemic effect. In DDPH free radical (DFR) and ferric-reducing antioxidant power assays, HAE in a concentration dependent manner (25-100 μg/mL) displayed a strong scavenging activity with maximum effect of 88% and 75% at 100 μg/mL, respectively. Daily administration of HAE (50 mg/kg; p.o.) in the in vivo model of alloxan-induced diabetic rabbits for 28 days showed significant reduction in glycaemia, also supported by recovery of body weight. In conclusion, our results give preliminary information on the potential use of this plant as a nutraceutical, useful to control and/or prevent a hyperglycaemic status.

  8. A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?

    Science.gov (United States)

    Salehi, Nooshin; Choi, Eric D; Garrison, Roger C

    2017-01-16

    BACKGROUND Miller Fisher Syndrome is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia, and is considered to be a variant of Guillain-Barre Syndrome. Miller Fisher Syndrome is observed in approximately 1-5% of all Guillain-Barre cases in Western countries. Patients with Miller Fisher Syndrome usually have good recovery without residual deficits. Venous thromboembolism is a common complication of Guillain-Barre Syndrome and has also been reported in Miller Fisher Syndrome, but it has generally been reported in the presence of at least one prothrombotic risk factor such as immobility. A direct correlation between venous thromboembolism and Miller Fisher Syndrome or Guillain-Barre Syndrome has not been previously described. CASE REPORT We report the case of a 32-year-old Hispanic male who presented with acute, severe thromboembolic disease and concurrently demonstrated characteristic clinical features of Miller Fisher Syndrome including ophthalmoplegia, ataxia, and areflexia. Past medical and family history were negative for thromboembolic disease, and subsequent hypercoagulability workup was unremarkable. During the course of hospitalization, the patient also developed angioedema. CONCLUSIONS We describe a possible association between Miller Fisher Syndrome, thromboembolic disease, and angioedema.

  9. Review of the genus Fontidessus Miller & Spangler, 2008 (Coleoptera, Dytiscidae, Hydroporinae, Bidessini with description of four new species

    Directory of Open Access Journals (Sweden)

    Kelly Miller

    2014-07-01

    Full Text Available The genus Fontidessus Miller & Spangler, 2008 (Coleoptera: Dytiscidae: Hydroporinae: Bidessini is reviewed. The genus now includes seven species with three previously described, and four new species described here: F. microphthalmus Miller & Montano, sp. n.; F. bettae Miller & Montano, sp. n.; F. christineae Miller & Montano, sp. n., and F. aquarupe Miller & Montano, sp. n. Each species is diagnosed and described, including the previously known species, based on new specimens and new information. Habitus, male genitalia and other diagnostic features are illustrated for each species. A key to the seven species is provided. Fontidessus species are unique to hygropetric habitats in the Guiana Shield craton of northern South American.

  10. Varieties of openness and types of digital anthropology: avoiding confusion in discussing Danny Miller

    OpenAIRE

    David Zeitlyn; Stephen M. Lyon

    2012-01-01

    Response to Miller's article in Hau 2012: http://www.haujournal.org/index.php/hau/article/view/93/114 about open access publishing in anthropology and various other topics such as linguistic hegemony and digital anthropology

  11. Traumatic brain injury is unlikely precipitating Leigh syndrome due to the GJB2 mutation c.35delG

    Directory of Open Access Journals (Sweden)

    Josef Finsterer

    2017-06-01

    Full Text Available With interest we read the article by Ashrafi et al. about a 14-year-old female who is regarded to have developed Leigh syndrome (LS after traumatic brain injury (TBI. We have the following comments and concerns:We do not agree with the notion that traumatic brain injury was the precipitating factor for LS. The patient had a history of hypoacusis, which is a typical clinical manifestation of a mitochondrial disorder (MID. Hypoacusis obviously had developed long before the TBI. Additionally, the patient was diagnosed with neuropathy of the peripheral nerves two months after TBI. It is rather unlikely that neuropathy was triggered by TBI and more likely it was already present before the trauma. Thus, the initial manifestations of LS in the presented patient were most likely hypoacusis followed by neuropathy and TBI only might have triggered the seizure but not the MID. Why was the patient put on phenytoin, which is well-known to be mitochondrion-toxic? Phenytoin may worsen epilepsy and MID in general and it is conceivable that in fact phenytoin was responsible for worsening of the phenotype and not the TBI. In a 16-year-old female with MELAS syndrome due to the mutation m.3243A>G, phenytoin caused intestinal pseudo-obstruction one month after intravenous phenytoin for status epilepticus. In a patient with Kearns-Sayre syndrome phenytoin decreased cerebrospinal fluid (CSF folate levels. In rat hepatocytes, phenytoin increased reactive oxygen species (ROS formation, decreased intracellular reduced glutathione, increased intracellular oxidised glutathione, and enhanced lipid peroxidation and mitochondrial damage. In a hepatic microsomal system, phenytoin decreased state-3 respiration, ATP synthesis, and the mitochondrial membrane potential. In this model, phenytoin increased state-4 respiration, impaired Ca++-uptake and release, and inhibited Ca++-induced swelling. It would be interesting to know how the GJB2 mutation was detected. Was whole exome or

  12. Syndrome de Miller Fisher avec anticorps anti GQ1b négatif au ...

    African Journals Online (AJOL)

    Le Syndrome de Miller Fisher est caractérisé par l'association d'une ophtalmoplégie, d'une ataxie et d'une aréflexie ostéo-tendineuse. Une infection virale est le plus souvent retrouvée dans les jours ou semaines qui précèdent la symptomatologie. Nous rapportons un cas de syndrome de Miller Fisher survenu chez une ...

  13. Cerebellar and pontine tegmental hypermetabolism in miller-fisher syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yu Kyrong; Kim, Ji Soo; Lee, Won Woo; Kim, Sang Eun [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    Miller Fisher syndrome (MFS) has been considered as a variant of Guillain-Barre syndrome (GBS), a type of acute immune neuropathies involving peripheral nerve system. Unlike GBS, presence of cerebellar type ataxia and supranuclear ophthalmioplesia in MFS suggests additional involvement of the central nervous system. To determine involvement of the central nervous system in MFS, we investigated the cerebral metabolic abnormalities in patients with MFS using FDG PET. Nine patients who were diagnosed as MFS based on acute ophthalmoplegia, ataxia, and areflexia without other identifiable causes participated in this study. In six patients, serum antibodies possibly related with symptom of MFS (anti- GQ1b or anti-GM1) were detected at the time of the study. With the interval of 25 26 days (range: 3-83 days) from the symptom on set, brain FDG PET were underwent in patients and compared with those from healthy controls. In group analysis comparing with healthy controls, FDG PET of patients revealed increased metabolism in the bilateral cerebellar hemispheres and vermis, and the thalamus. In contrast, the occipital cortex showed decreased metabolism. Individual analyses disclosed hypermetabolism in the cerebellar vermis or hemispheres in 5, and in the pontine tegmentum in 2 of the 9 patients. We also found that the cerebellar vermian hypermetabolism was inversely correlated with the interval between from the symptom on set to PET study. Moreover, follow-up PET of a patient demonstrated that cerebellar hypermetabolism decreased markedly with an improvement of the ophthalmoplegia and ataxia. These findings indicate an involvement of the central nervous system in MFS and suggest an antibody-associated acute inflammatory process as a mechanism of this disorder.

  14. Cerebellar and pontine tegmental hypermetabolism in miller-fisher syndrome

    International Nuclear Information System (INIS)

    Kim, Yu Kyrong; Kim, Ji Soo; Lee, Won Woo; Kim, Sang Eun

    2007-01-01

    Miller Fisher syndrome (MFS) has been considered as a variant of Guillain-Barre syndrome (GBS), a type of acute immune neuropathies involving peripheral nerve system. Unlike GBS, presence of cerebellar type ataxia and supranuclear ophthalmioplesia in MFS suggests additional involvement of the central nervous system. To determine involvement of the central nervous system in MFS, we investigated the cerebral metabolic abnormalities in patients with MFS using FDG PET. Nine patients who were diagnosed as MFS based on acute ophthalmoplegia, ataxia, and areflexia without other identifiable causes participated in this study. In six patients, serum antibodies possibly related with symptom of MFS (anti- GQ1b or anti-GM1) were detected at the time of the study. With the interval of 25 26 days (range: 3-83 days) from the symptom on set, brain FDG PET were underwent in patients and compared with those from healthy controls. In group analysis comparing with healthy controls, FDG PET of patients revealed increased metabolism in the bilateral cerebellar hemispheres and vermis, and the thalamus. In contrast, the occipital cortex showed decreased metabolism. Individual analyses disclosed hypermetabolism in the cerebellar vermis or hemispheres in 5, and in the pontine tegmentum in 2 of the 9 patients. We also found that the cerebellar vermian hypermetabolism was inversely correlated with the interval between from the symptom on set to PET study. Moreover, follow-up PET of a patient demonstrated that cerebellar hypermetabolism decreased markedly with an improvement of the ophthalmoplegia and ataxia. These findings indicate an involvement of the central nervous system in MFS and suggest an antibody-associated acute inflammatory process as a mechanism of this disorder

  15. Human radiation studies: Remembering the early years. Oral history of radiologist Earl R. Miller, M.D., August 9 and 17, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    Dr. Earl R. Miller was interviewed by representatives of US DOE Office of Human Radiation Research (OHRE). The interview covers Dr. Miller`s involvement with the Manhattan Engineer District, with total body irradiation, and heavy-ion therapy. Dr. Miller`s remembrances include wartime work on radiation exposure, Joe Hamilton, Neutron Therapy research, means of obtaining isotopes, consent forms, infinite laminograms, invention of a baby holder to alleviate exposure of radiological technicians in diagnostic procedures involving infants, and several personages.

  16. Migration and New Media: Transnational Families and Polymedia by Mirca Madianou and Daniel Miller (Routledge, 2012

    Directory of Open Access Journals (Sweden)

    Erwin Gaspar A. Alampay

    2012-06-01

    Full Text Available In 2007, Daniel Miller presented his paper on “What is a Mobile PhoneRelationship” in the “1st Living the Information Society Conference” held inManila. In his presentation, he mentioned the work he was just embarking onwith Mirca Madianou on long-distance relationships of separated families andthe ability of different media to sustain those relationships over time (Miller,2009. He was then building on the extensive work that Parrenas (2001, 2005a,2005b had done on Filipino transnational families, and in particular, on motheringfrom a distance

  17. The 1953 Stanley L. Miller Experiment: Fifty Years of Prebiotic Organic Chemistry

    Science.gov (United States)

    Lazcano, Antonio; Bada, Jeffrey L.

    2003-01-01

    The field of prebiotic chemistry effectively began with a publication in Science 50 years ago by Stanley L. Miller on the spark discharge synthesis of amino acids and other compounds using a mixture of reduced gases that were thought to represent the components of the atmosphere on the primitive Earth. On the anniversary of this landmark publication, we provide here an accounting of the events leading to the publication of the paper. We also discuss the historical aspects that lead up to the landmark Miller experiment.

  18. Urban orature and resistance: The case of Donny Elwood ...

    African Journals Online (AJOL)

    ... this trajectory when independence failed to deliver on the aspiration of the masses. Today's artists follow in the footsteps of their predecessors; resisting all forms of social injustice, economic inequality and political oppression that bedevil the post-independence arena. Using resistance aesthetics as critical tool of analysis, ...

  19. Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome

    Directory of Open Access Journals (Sweden)

    Byron Chen

    2017-08-01

    Full Text Available Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. Basal ganglia nuclei, including the striatum, are affected in LS patients. However, neither the identity of the affected cell types in the striatum nor their contribution to the disease has been established. Here, we used a mouse model of LS lacking Ndufs4, a mitochondrial complex I subunit, to confirm that loss of complex I, but not complex II, alters respiration in the striatum. To assess the role of striatal dysfunction in the pathology, we selectively inactivated Ndufs4 in the striatal medium spiny neurons (MSNs, which account for over 95% of striatal neurons. Our results show that lack of Ndufs4 in MSNs causes a non-fatal progressive motor impairment without affecting the cognitive function of mice. Furthermore, no inflammatory responses or neuronal loss were observed up to 6 months of age. Hence, complex I deficiency in MSNs contributes to the motor deficits observed in LS, but not to the neural degeneration, suggesting that other neuronal populations drive the plethora of clinical signs in LS.

  20. Clinical and molecular features of an infant patient affected by Leigh Disease associated to m.14459G > A mitochondrial DNA mutation: a case report

    Directory of Open Access Journals (Sweden)

    Moggio Maurizio

    2011-07-01

    Full Text Available Abstract Background Leigh Syndrome (LS is a severe neurodegenerative disorder characterized by bilateral symmetrical necrotic lesions in the basal ganglia and brainstem. Onset is in early infancy and prognosis is poor. Causative mutations have been disclosed in mitochondrial DNA and nuclear genes affecting respiratory chain subunits and assembly factors. Case presentation Here we report the clinical and molecular features of a 15-month-old female LS patient. Direct sequencing of her muscle-derived mtDNA revealed the presence of two apparently homoplasmic variants: the novel m.14792C > G and the already known m.14459G > A resulting in p.His16Asp change in cytochrome b (MT-CYB and p.Ala72Val substitution in ND6 subunit, respectively. The m.14459G > A was heteroplasmic in the mother's blood-derived DNA. Conclusions The m.14459G > A might lead to LS, complicated LS or Leber Optic Hereditary Neuropathy. A comprehensive re-evaluation of previously described 14459G > A-mutated patients does not explain this large clinical heterogeneity.

  1. Giving Psychology Away: How George Miller's Vision Is Being Realised by Psychological Literacy

    Science.gov (United States)

    Banyard, Philip; Hulme, Julie A.

    2015-01-01

    In George Miller's famous address to the American Psychological Association in 1969 he explored the aims and future direction of psychology. Psychology could develop as a professional elite that develops specialised knowledge that experts can hold on to or it could aim to "give psychology away" and to allow the general public access to…

  2. 76 FR 18151 - Kootenai National Forest, Lincoln County, MT; Miller West Fisher Project

    Science.gov (United States)

    2011-04-01

    ... creation in Miller Creek, improvement of trails and trailheads, fuels management and hazard tree removal in... regarding the grizzly bear analysis. The District Judge remanded the project to the Forest Service to... improvements for safety; fuels reduction and hazard tree removal in the Lake Creek Campground; spring...

  3. 75 FR 81331 - Surety Companies Acceptable on Federal Bonds: Termination-Penn Millers Insurance Company

    Science.gov (United States)

    2010-12-27

    ... should be accepted from this company, and bonds that are continuous in nature should not be renewed. The... DEPARTMENT OF THE TREASURY Fiscal Service Surety Companies Acceptable on Federal Bonds: Termination--Penn Millers Insurance Company AGENCY: Financial Management Service, Fiscal Service, Department...

  4. Search for Self in Arthur Miller's The Death of a Salesman | Maleki ...

    African Journals Online (AJOL)

    The quest for self is expressed through a nostalgic yearning for the past, which has been lost due to various reasons. The process of search for self is spread over two generations, which enhances the effectiveness of Miller in depicting the struggle between the self of an individual and the public self the individual is ...

  5. HIV life cycle and potential targets for drug activity | Miller | Southern ...

    African Journals Online (AJOL)

    HIV life cycle and potential targets for drug activity. S Miller. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

  6. Is There Really Insufficient Support for Tilman's R* Concept? A comment on Miller et al.

    NARCIS (Netherlands)

    Wilson, J.B.; Spijkerman, E.; Huisman, J.

    2007-01-01

    Miller et al. (2005), in the American Naturalist (165:439-448), critically reviewed the applicability of Tilman's resource-ratio hypothesis. One of their conclusions was that only eight experimental papers support the R* concept, while five do not. We are familiar with some of the latter studies,

  7. Síndrome de Miller Fisher e neurite óptica: relato de caso

    Directory of Open Access Journals (Sweden)

    CARVALHO ALZIRA A. SIQUEIRA

    2000-01-01

    Full Text Available Descreve-se um caso de síndrome de Miller Fisher associada a neuropatia óptica desmielinizante bilateral, confirmada pelo exame de potencial evocado visual, sugerindo possível comprometimento do sistema nervoso central nessa síndrome.

  8. A Tribute to Professor Rene H. Miller - A Pioneer in Aeromechanics and Rotary Wing Flight Transportation

    Science.gov (United States)

    Friedmann, Peretz P.; Johnson, Wayne; Scully, Michael P.

    2011-01-01

    Rene H. Miller (May 19, 1916 January 28, 2003), Emeritus H. N. Slater Professor of Flight Transportation, was one of the most influential pioneers in rotary wing aeromechanics as well as a visionary whose dream was the development of a tilt-rotor based short haul air transportation system. This paper pays a long overdue tribute to his memory and to his extraordinary contributions.

  9. Pharmacy profile. New ASCP president Robert J. Miller: entrepreneur who puts the patient first.

    Science.gov (United States)

    Meade, Vicki

    2005-10-01

    Bob Miller, known for his enthusiasm and desire to nurture others' growth, brings to his term as 2005-2006 ASCP president the leadership skills and business acumen he developed over two decades as a long-term care pharmacy owner.

  10. Dialogue: Manpower Policies for the 70's

    Science.gov (United States)

    New Generation, 1972

    1972-01-01

    Summarizes the results of a discussion among S. M. Miller, R. D. Corwin, Dennis A. Derryck, Marcia Freedman, Sar Levitan, Jerome Rosow, Robert Schrank, and Elwood Taub on manpower policies for the 1970's. (JM)

  11. Nitrogen isotope fractionations in the Fischer-Tropsch synthesis and in the Miller-Urey reaction

    International Nuclear Information System (INIS)

    Chun-Chan Kung; Hayatsu, R.; Studier, M.H.; Clayton, R.N.; Chicago Univ., IL; Chicago Univ., IL

    1979-01-01

    Nitrogen isotope fractionations have been measured in Fischer-Tropsch and Miller-Urey reactions in order to determine whether these processes can account for the large 15 N/ 14 N ratios found in organic matter in carbonaceous chondrites. Polymeric material formed in the Fischer-Tropsch reaction was enriched in 15 N by only 3 promille relative to the starting material (NH 3 ). The 15 N enrichment in polymers from the Miller-Urey reaction was 10-12 promille. Both of these fractionations are small compared to the 80-90 promille differences observed between enstatite chondrites and carbonaceous chondrites. These large differences are apparently due to temporal or spatial variations in the isotopic composition of nitrogen in the solar nebula, rather than to fractionation during the production of organic compounds. (orig.)

  12. Effect of Hydroalcoholic Extract of Cydonia oblonga Miller (Quince on Sexual Behaviour of Wistar Rats

    Directory of Open Access Journals (Sweden)

    Muhammad Aslam

    2014-01-01

    Full Text Available Cydonia oblonga Miller (quince is regarded as a potent libido invigorator in Tib-e-Nabvi and Unani System of Medicine. This study was carried out to evaluate the aphrodisiac activity of the hydroalcoholic extract of the fruits of Cydonia oblonga Miller (quince in Wistar rats. The extract was administered orally by gavage in the dose of 500 mg/kg and 800 mg/kg body weight per day as a single dose for 28 days. The observed parameters were mounting frequency, assessment of mating performance, and orientation activities towards females, towards the environment, and towards self. The results showed that after administration of the extract mounting frequency and the mating performance of the rats increased highly significantly P<0.01. The extract also influenced the behaviour of treated animals in comparison to nontreated rats in a remarkable manner, making them more attracted to females. These effects were observed in sexually active male Wistar rats.

  13. Acute Bilateral Ophthalmoparesis with Pupilary Areflexical Mydriasis in Miller-Fisher Syndrome Treated with Intravenous Immunoglobulin

    Directory of Open Access Journals (Sweden)

    Theocharis Papanikolaou

    2010-01-01

    Full Text Available Miller-Fisher syndrome (MFS is a rare condition characterized by the classical triad of ophthalmoplegia, ataxia, and areflexia (Fisher, 1956. It is considered a variant of Guillain-Barré syndrome (GBS with which it may overlap, or it can occur in more limited forms. We report a case of a thirty-five-year-old male who presented with a six-day history of diplopia, following a recent chest infection. On examination, he was found to have bilateral sixth nerve palsy, bilateral fourth nerve palsy, bilateral areflexical mydriasis, ataxia and total absence of reflexes. After excluding other conditions, a diagnosis of Miller-Fisher syndrome was made. The patient was administered intravenous immunoglobulin and made an uneventful recovery.

  14. Opuntia ficus-indica (L.) Miller as a source of bioactivity compounds for health and nutrition.

    Science.gov (United States)

    Aragona, M; Lauriano, E R; Pergolizzi, S; Faggio, C

    2017-08-14

    Plants with beneficial properties are known in traditional medicine. Nowadays, in spite of widespread availability of synthetic compounds, the search goes towards natural compounds to lower cost and few side effects. The increasing interest in preventive medicine encourages use of nutraceuticals, bioactive compounds of vegetable origin with important nutritional values. Among the medicinal plants, Opuntia ficus-indica (L.) Miller (Family Cactaceae, subfamily Opuntiodeae, Genus Opuntia, subgenus Platyopuntia, species Opuntia ficus-indica (L.) Miller) is widely known for its beneficial properties. The aim of the present review is to stress the major classes of Opuntia components and their medical interest through emphasis on some of their biological effects, particularly those having the most promising expected health benefits and therapeutic impacts on fish and mammals.

  15. Utilization of Lavandula angustifolia Miller extracts as naturalrepellents, pharmaceutical and industrial auxiliaries

    Directory of Open Access Journals (Sweden)

    AYOE YUSUFOGLU

    2004-01-01

    Full Text Available Essential oils, absolutes and concretes were prepared from the flowers and leaves of the plant Lavandula angustifolia Miller cultivated in the Bosphorus region of Istanbul, Turkey. The difference in the chemical composition of the mentioned extracts was investigated and compared by using a combination of capillary GC-MS with the aim of offering them as repellent, pharmaceutical and industrial auxiliaries. The IR-spectra, the yields and the physico-chemical data of the extracts were also analysed.

  16. Gabriella Miller Kids First (GMKF/Kids First) Pediatric Research Program | Office of Cancer Genomics

    Science.gov (United States)

    The Gabriella Miller Kids First initiative is a trans-NIH effort to increase understanding of genetic changes associated with certain devastating pediatric conditions. The initiative will develop a centralized database of well-curated clinical and genetic sequence data from childhood cancer and structural birth defects cohorts comprising thousands of patients and their families. To learn more about the initiative and the data available, please visit https://commonfund.nih.gov/kidsfirst

  17. ALOE VERA BARBADENSIS MILLER AS AN ALTERNATIVE TREATMENT FOR CHILDREN WITH FEVER

    Directory of Open Access Journals (Sweden)

    Siti Choirul Dwi Astuti

    2017-10-01

    Full Text Available Background: Applying a cooling treatment from outside the body is one way to lower fever in children. Midwives commonly perform a warm water compress in their care, but it is considered less effective. Thus, compress with aloe vera barbadensus miller is proposed in this study as an alternative treatment. Objective: To examine the effect of Aloe vera barbadensis miller compress in reducing body temperature in children with fever. Methods: This was a quasi-experimental study with pretest and posttest with control group design. Forty children were recruited, with twenty of them assigned in each group. Purposive sampling was performed to select the sample. A digital rectal thermometer was used to measure the temperature. Independent t- test and paired test were used for data analysis. Results: Findings showed that the aloe vera compress group showed a higher decrease of body temperature compared to the warm water compress group. The difference of body temperature after 20 minutes in the experiment group was 1.435 while in the control group was only 1.085. There were statistically significant differences in body temperature between the experiment and control group (p=0.013. Conclusion: Aloe vera barbadensis miller compress is an effective alternative therapy in reducing body temperature in children with fever. It is recommended for midwives to apply this intervention to reduce body temperature significantly.

  18. High Miller-index germanium crystals for high-energy x-ray imaging applications.

    Science.gov (United States)

    Koch, J A; Lee, J J; Haugh, M J

    2015-12-01

    Near-normal-incidence bent crystals are widely used for x-ray imaging applications. Advantages include high collection solid angle and potentially high efficiency for narrow-band sources, while disadvantages include relatively large (several Å) interatomic spacings and a limited number of suitable matches between a crystal 2d value and an integral multiple of useful emission line wavelengths. The disadvantages become more significant at x-ray energies >10  keV. The former disadvantage can be mitigated by using high-order reflections from crystal planes having low Miller indices, but both disadvantages can be mitigated by using low-order reflections from crystal planes having high Miller indices. We report here on integrated reflectivity measurements we performed of Ge (15,7,7) (2d=0.6296  Å), a candidate for imaging Ru He-α (θ(B)=87°). We find good agreement with calculations, and the data show a multitude of closely spaced reflections with slightly different Bragg angles including a fifth-order reflection of Ge (3,1,1) that has comparable reflectivity. This demonstrates that arbitrary choices of Miller indices in Ge crystals can be used to fine-tune Bragg angles for near-normal-incidence x-ray imaging at tens of kiloelectron volt x-ray energies with minimal lower-energy contamination from lower-order reflections, and that existing calculational tools can be used to reliably estimate integrated reflectivity.

  19. Review: Miller, Michelle Ann (2009, Rebellion and Reform in Indonesia – Jakarta’s Security and Autonomy Policies in Aceh

    Directory of Open Access Journals (Sweden)

    Antje Missbach

    2009-01-01

    Full Text Available Review of the monograph: Miller, Michelle Ann, Rebellion and Reform in Indonesia – Jakarta’s Security and Autonomy Policies in Aceh, London/ New York: Routledge, 2009, ISBN 13: 978-0-415-45467-4, 240 pages.

  20. Téma: David Miller o nacionalismu a globální spravedlnosti. Úvod

    Czech Academy of Sciences Publication Activity Database

    Velek, Josef

    2007-01-01

    Roč. 55, č. 2 (2007), s. 39-41 ISSN 0015-1831 Institutional research plan: CEZ:AV0Z90090514 Keywords : nationalism * cosmopolitanism * global justice * D. Miller Subject RIV: AA - Philosophy ; Religion

  1. PREPARATION OF GLIMEPIRIDE ALOE BARBADENSIS MILLER LEAVES MUCILAGE AND POVIDONE CONTROLLED RELEASE MATRIX TABLETS: IN VITRO AND IN VIVO EVALUATION

    OpenAIRE

    Hindustan Abdul Ahad; Sreeramulu J; Hima Bindu V; Guru Prakash P; Sravanthi M

    2011-01-01

    The main purpose of the present study was to prepare Glimepiride matrix tablets with Aloe barbadensis miller leaves mucilage and Povidone and to study its novelty as a matrix forming polymer for controlled release tablet formulations. Physicochemical properties of the dried powdered Aloe barbadensis miller mucilage and Povidone blend, drug-excipient compatibility studies, pre formulation studies, post formulation studies, in vitro drug release studies, mathematical modeling of in vitro dissol...

  2. An analytic study of applying Miller cycle to reduce NO{sub x} emission from petrol engine

    Energy Technology Data Exchange (ETDEWEB)

    Wang Yaodong [School of Marine Science and Technology, Newcastle University, Newcastle upon Tyne, NE1 7RU (United Kingdom) and Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China)]. E-mail: y.d.wang@ncl.ac.uk; Lin Lin [Nanning College for Vocational Technology, Nanning, Guangxi 530003 (China); Roskilly, Anthony P. [School of Marine Science and Technology, Newcastle University, Newcastle upon Tyne, NE1 7RU (United Kingdom); Zeng Shengchuo [Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China); Huang, Jincheng [Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China); He Yunxin [Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China); Huang Xiaodong [Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China); Huang Huilan [Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China); Wei Haiyan [Mechanical Engineering College, Guangxi University, Nanning, Guangxi 530004 (China); Li Shangping [Guangxi University of Technology, Liuzhou 545006 (China); Yang Jing [Mechanical Engineering College, University of Science and Technology Beijing, Beijing (China)

    2007-08-15

    An analytic investigation of applying Miller cycle to reduce nitrogen oxides (NO{sub x}) emissions from a petrol engine is carried out. The Miller cycle used in the investigation is a late intake valve closing version. A detailed thermodynamic analysis of the cycle is presented. A comparison of the characters of Miller cycle with Otto cycle is presented. From the results of thermodynamic analyses, it can be seen that the application of Miller cycle is able to reduce the compression pressure and temperature in the cylinder at the end of compression stroke. Therefore, it lowers down the combustion temperature and NO{sub x} formation in engine cylinder. These results in a lower exhaust temperature and less NO{sub x} emissions compared with that of Otto cycle. The analytic results also show that Miller cycle ratio is a main factor to influence the combustion temperature, and then the NO{sub x} emissions and the exhaust temperature. The results from the analytic study are used to analyse and to compare with the previous experimental results. An empirical formula from the previous experimental results that showed the relation of NO{sub x} emissions with the exhaust temperature at different engine speed is presented. The results from the study showed that the application of Miller cycle may reduce NO{sub x} emissions from petrol engine.

  3. Validation of the Thomson, Perry and Miller (2007 Collaboration Instrument in the South African context

    Directory of Open Access Journals (Sweden)

    Debbie Roberts

    2017-02-01

    Full Text Available Orientation: Collaboration is deemed important in today’s connected and complex business environment. People’s ability to collaborate with each other in organisations is becoming a business imperative. This study focuses on a valid measurement of collaboration within organisations. Research purpose: Thomson, Perry and Miller (2007 developed a collaboration measurement instrument in the United States. The aim of this study was to validate this instrument for a South African context. Motivation for the study: South African organisations face unique challenges that require optimal use of resources to improve business results. Effective collaboration is considered a powerful strategy to achieve this. Measuring the extent of collaboration can help to identify required changes in business practices. As far as could be established, there is no evidence of collaboration instruments developed and validated in South Africa. Research design, approach and method: Additional items were designed for further development of the Thomson, Perry and Miller (2007 Collaboration Instrument sub-scales, as suggested by the authors. The revised questionnaire consisting of 31 (17 existing, 14 new items was distributed electronically to 4200 employees in two organisations, with 343 valid responses received. Reliability and construct validity were tested, as was convergent validity of the norms factor with the Trust in Teams Scale. Main findings: The results of the study support a four-factor, 29-item model of collaboration when applied to a South African sample. Cronbach’s alpha ranged between 0.85 and 0.95. Confirmatory Factor Analysis fits were at an acceptable level. Convergent validity showed a moderate fit with the data. Practical/managerial implications: South African managers and human resources practitioners can utilise results to foster a collaborative environment. Contribution/value-add: This study builds on the theoretical concept of collaboration as

  4. Validation of the Thomson, Perry and Miller (2007 Collaboration Instrument in the South African context

    Directory of Open Access Journals (Sweden)

    Debbie Roberts

    2017-01-01

    Full Text Available Orientation: Collaboration is deemed important in today’s connected and complex business environment. People’s ability to collaborate with each other in organisations is becoming a business imperative. This study focuses on a valid measurement of collaboration within organisations.Research purpose: Thomson, Perry and Miller (2007 developed a collaboration measurement instrument in the United States. The aim of this study was to validate this instrument for a South African context.Motivation for the study: South African organisations face unique challenges that require optimal use of resources to improve business results. Effective collaboration is considered a powerful strategy to achieve this. Measuring the extent of collaboration can help to identify required changes in business practices. As far as could be established, there is no evidence of collaboration instruments developed and validated in South Africa.Research design, approach and method: Additional items were designed for further development of the Thomson, Perry and Miller (2007 Collaboration Instrument sub-scales, as suggested by the authors. The revised questionnaire consisting of 31 (17 existing, 14 new items was distributed electronically to 4200 employees in two organisations, with 343 valid responses received. Reliability and construct validity were tested, as was convergent validity of the norms factor with the Trust in Teams Scale.Main findings: The results of the study support a four-factor, 29-item model of collaboration when applied to a South African sample. Cronbach’s alpha ranged between 0.85 and 0.95. Confirmatory Factor Analysis fits were at an acceptable level. Convergent validity showed a moderate fit with the data.Practical/managerial implications: South African managers and human resources practitioners can utilise results to foster a collaborative environment.Contribution/value-add: This study builds on the theoretical concept of collaboration as defined by

  5. Why there is no supernatural morality: response to Miller's opening statement.

    Science.gov (United States)

    Shermer, Michael

    2016-11-01

    If one is going to argue that objective morality depends on an Archimedean point outside the natural world, then it would seem to imply that this source is necessarily supernatural. Thus, Christian Miller begins by defining precisely who he thinks this supernatural moral law giver is: the omniscient, omnipotent, and omnibenevolent creator of the universe who is still actively involved with human affairs-Elohim, Jehovah, Yahweh, or Allah-aka God. Already I'm skeptical. © 2016 New York Academy of Sciences.

  6. Antioxidant and antimicrobial properties of Casteanea sativa Miller chestnut honey produced on Mount Etna (Sicily).

    Science.gov (United States)

    Ronsisvalle, Simone; Lissandrello, Edmondo; Fuochi, Virginia; Petronio Petronio, Giulio; Straquadanio, Claudia; Crascì, Lucia; Panico, Annamaria; Milito, Marcella; Cova, Anna Maria; Tempera, Gianna; Furneri, Pio Maria

    2017-12-13

    The aim of this study was the evaluation of antibacterial and antioxidant properties of Monofloral Etna Castanea sativa Miller honeys. Escherichia coli ATCC 25,922, Pseudomonas aeruginosa ATCC 27,853, Enterococcus faecalis ATCC 29,211 and Staphylococcus aureus ATCC 29,213 were investigated for their susceptibilities to two different honeys. Antioxidant activity was evaluated by ORAC, NO scavenger assays, FRAP and DPPH. Antioxidant activity and antibacterial properties were compared with chestnut honeys from different geographical areas and with Manuka honey. UPLC-MS/MS was used for major components characterisation.

  7. Lee Miller à travers la Roumanie, l’appareil photo à la main (1946

    Directory of Open Access Journals (Sweden)

    Adrian-Silvan Ionescu

    2012-01-01

    Full Text Available A former model and fashion photographer turned war photographer, Lee Miller visited Romania twice, in 1938 and 1946 respectively. After her second visit she published her impressions and pictures, under the title of Roumania, in Vogue magazine. Besides the published material there are her manuscripts from The Lee Miller Achives at Farley Farm House, East Sussex, England, on which this paper is based. She crossed the border coming from Hungary in early February 1946. Heading for Sibiu her car, a Chevrolet Sedan, slipping on the ice-covered road, stopped on a snowbank far off in the ditch. While looking for help in the nearby village she and her companions left the car unguarded to discover it plundered of everything, wheels included.On a Sunday afternoon she had the privilege of being received by King Mihai I and Queen Mother Elena with whom she talked exstensively. She also took magnificent pictures with the Royal Family in the imposing Peleş Castle. At Sinaia, „the summer capital of Roumania” she had also the opportunity to portray Dinu Brătianu and Iuliu Maniu, the two elderly statesmen. Maniu was surrounded by friends and party members, among whom was young Corneliu Coposu, his private secretary.Moving to Bucharest, she met old friends such as Harri Brauner and his wife, Lena Constante, with whom she wandered through the country eight years ago. Lena and Elena Pătrășcanu, wife of Lucrețiu Pătrășcanu, Minister of Justice, have started a successful marionette theatre where Lee took nice pictures. Other were taken on the streets, with peasants, street vendors and their customers. Harri took her to a bistro where they met Maria Lătărețu, the celebrating folk singer whom Brauner recorded many times. They enjoyed her songs. Suffering from fibrositis, Lee Miller undertook a peculiar treatment in a gypsy village where the inhabitants were dancing bears trainers. She was massaged by a bear weighing about 300 pounds while Brauner took

  8. Chromatographic separation and detection methods of Aloe arborescens Miller constituents: A systematic review.

    Science.gov (United States)

    Nazeam, Jilan A; Gad, Haidy A; El-Hefnawy, Hala M; Singab, Abdel-Naser B

    2017-07-15

    Aloe arborescens Miller (Family Asphodelaceae) is a member of genus Aloe, which is used in traditional medicine to cure various diseases. The extracts of the plant have been reported to possess anticancer, immunomodulator, antidiabetic, anti-inflammatory and antioxidant activities. The phytochemical investigations have revealed diverse chemical constituents, including phenolics [anthraquinones, anthrones, pyrones, chromones and coumarins], polysaccharides [arborans [(1-4) linked glucomannans, polysaccharide (A, B and C): (A: a linear (1-6)-O-α-glucan, B: a branching (1-2)-O-l-arabinose with (1-2)-O-d-galactose linkages and C: (1-4)-O-β-mannan with 18% acetyl group)

  9. Human radiation studies: Remembering the early years. Oral history of radiologist Earl R. Miller, M.D., August 9 and 17, 1994

    International Nuclear Information System (INIS)

    1995-06-01

    Dr. Earl R. Miller was interviewed by representatives of US DOE Office of Human Radiation Research (OHRE). The interview covers Dr. Miller's involvement with the Manhattan Engineer District, with total body irradiation, and heavy-ion therapy. Dr. Miller's remembrances include wartime work on radiation exposure, Joe Hamilton, Neutron Therapy research, means of obtaining isotopes, consent forms, infinite laminograms, invention of a baby holder to alleviate exposure of radiological technicians in diagnostic procedures involving infants, and several personages

  10. I teoremi di Modigliani-Miller: una pietra miliare della finanza (The theorems of Modigliani-Miller: a cornerstone of finance

    Directory of Open Access Journals (Sweden)

    Marco Pagano

    2012-04-01

    Full Text Available The theorems of Modigliani and Miller (MM is a cornerstone of finance for two reasons.The first is substantial and is derived from the nature of "propositions irrelevant": they identify a case in which the financial structure and dividend policy will not affect the value of firms, and in doing so give us a clear point of reference to understand instead what circumstances these decisions affect the value of firms, and why. In fact, the whole subsequent evolution of corporate finance has explored the consequences of removing the assumptions of MM. The second reason for the importance of the fundamental theorems of MM is methodological: they have been demonstrated with a reasoning based arbitrage, which has set a precedent not only in the area of ​​corporate finance but also in that of the determination of prices of financial securities. I teoremi di Modigliani e Miller (MM sono una pietra miliare della finanza per due ragioni. La prima è sostanziale e deriva dalla loro natura di “proposizioni di irrilevanza”: essi individuano un caso in cui la struttura finanziaria e la politica dei dividendi non influiscono sul valore delle imprese, e così facendo ci danno un chiaro punto di riferimento per capire in quali circostanze invece queste decisioni influiscono sul valore delle imprese, e perché. In effetti, l’intera evoluzione successiva della finanza aziendale ha esplorato le conseguenze della rimozione delle ipotesi di MM. La seconda ragione dell’importanza fondamentale dei teoremi di MM è di tipo metodologico: essi sono stati dimostrati con un ragionamento basato sull’arbitraggio, il che ha stabilito un precedente non solo nel campo della finanza aziendale ma anche e soprattutto in quello della determinazione dei prezzi dei titoli finanziari.  JEL Codes: G32, G35Keywords: struttura finanziaria; politica dei dividendi; valore delle imprese

  11. Identification of a natural recombinant transmissible gastroenteritis virus between Purdue and Miller clusters in China.

    Science.gov (United States)

    Zhang, Xin; Zhu, Yunnuan; Zhu, Xiangdong; Shi, Hongyan; Chen, Jianfei; Shi, Da; Yuan, Jing; Cao, Liyan; Liu, Jianbo; Dong, Hui; Jing, Zhaoyang; Zhang, Jialin; Wang, Xiaobo; Feng, Li

    2017-08-23

    Transmissible gastroenteritis virus (TGEV) is an infective coronavirus (CoV) that causes diarrhea-related morbidity and mortality in piglets. For the first time, a natural recombination strain of a TGEV Anhui Hefei (AHHF) virus between the Purdue and the Miller clusters was isolated from the small intestine content of piglets in China. A phylogenetic tree based on a complete genome sequence placed the TGEV AHHF strain between the Purdue and the Miller clusters. The results of a computational analysis of recombination showed that the TGEV AHHF strain is a natural recombinant strain between these clusters. Two breakpoints located in the open reading frame 1a (ORF1a) and spike (S) genes were identified. The pathogenicity of the TGEV AHHF strain was evaluated in piglets, and the results show that TGEV AHHF is an enteric pathogenic strain. These results provide valuable information about the recombination and evolution of CoVs and will facilitate future investigations of the molecular pathogenesis of TGEV.

  12. Pornografia e transgressão na obra literária de Henry Miller

    Directory of Open Access Journals (Sweden)

    Raquel Catunda Pereira

    2016-07-01

    Full Text Available The North American writer Henry Miller was marginalized by literary critics since the first publications of his works in the 40s. Accused of being a pornographic text, the book Tropic of Cancer (1934 was forbidden in many countries. This article aims to analyze the obscene in Henry Miller’s work to prove that, beyond the erotic intention, Miller’s books are an expression of freedom and rejection of moral standards. In order to achieve our goal, we will use as theoretical basis the articles Criticismo e sexualidade: uma leitura de Tropico of Capricorn de Henry Miller, by Flávia Andréa Rodrigues Benfatt, and Literatura marginal americana: do épico confessional ao niilismo erótico, by Lainister de Oliveira. The texts mentioned above grant us the argumentation necessary to the analysis of pornographic discourse in Henry Miller’s literary works as the author’s aesthetics choice of taking himself as a transgressor in a decadent society.

  13. Concentrated nesting of mallards and gadwalls on Miller Lake Island, North Dakota

    Science.gov (United States)

    Duebbert, H.F.; Lokemoen, J.T.; Sharp, D.E.

    1983-01-01

    Island-nesting mallards (Anas platyrhynchos) and gadwalls (A. strepera) were studied on a 4.5-ha island in 385-ha Miller Lake in northwestern North Dakota during 1976-80. During the 5-year study, 2,561 duck nests of 9 species were found on Island A located 180 m offshore; 59% were mallard and 34% were gadwall. In patches of shrub cover, which contained the greatest concentrations of nests, densities ranged from 241 to 389 mallard nests/ha and from 139 to 237 gadwall nests/ha. Over 97% of the nests were placed in 4 patches of shrubs totaling about 1 ha of western snowberry (Symphoricarpos occidentalis)--Woods rose (Rosa woodsii) cover, which composed about 30% of the island's vegetation. Average hatching success was 85% for clutches of all species. Abandonment averaged 14% (348 of 2,426 nests) and was the major cause of egg failure. Only 15 nests (eggs in successful nests averaged 83% for mallards and 87% for gadwalls. Despite the close spacing of nests, most individual hens maintained normal nesting regimes. Eighty-one percent of the mallard clutches contained 7-13 eggs and 81% of the gadwall clutches contained 8-14 eggs. Island A in Miller Lake provides an outstanding example of the potential for high reproduction levels of mallards and gadwalls nesting in small areas of predator-free habitats.

  14. Compensator design using the par scientific miller and ADAC Pinnacle tps

    International Nuclear Information System (INIS)

    Arthur, G.; White, S.

    2001-01-01

    Full text: Ideal compensators are designed so that a uniform dose is given to a specific plane within the treatment volume despite variation in surface contour and non-homogeneity within the volume. Traditionally our department has designed compensators based on missing tissue alone and using lead sheet. We have now acquired a Par Scientific compensator miller and ADAC Pinnacle compensator design software. This poster sets out the investigations carried out to design compensators using this equipment. The investigation consisted of four parts. Part one was an evaluation of the Par Scientific miller's ability to accurately and to reproducibly mill various shapes from foam and cerrobend. It also included an examination of the effects due to varying the parameter options available in the software and the use of substitute milling bits. The second part was the choice of material to be used for the compensator. The following were investigated for moulds: steel grit; steel shot and cerrobend and for direct milling: cerrobend. Part three consisted of an investigation into the effects on compensator design with changes in the many parameter options available in ADAC software. For the final part compensators were designed using the ADAC software for both a Head and Neck, and a Mantle case. The compensators were made using the Par Scientific miller. This consisted of milling the required shape in foam and then filling it with cerrobend. TLDs were used to evaluate the compensators. Evaluation consisted of examining the uniformity of dose in the selected plane. The compensators were also compared to the traditional method for the same cases. Finally a comparison was made of the measured dose with that calculated by the ADAC Pinnacle planning system. The Par Scientific was found to be accurate and consistent, however not suitable for milling solid cerrobend directly. Investigations so far have shown that the use of molten cerrobend poured into milled foam moulds is the most

  15. Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?

    Directory of Open Access Journals (Sweden)

    Ioannis E. Dagklis

    2016-01-01

    Full Text Available Miller-Fisher syndrome (MFS is considered as a variant of the Guillain-Barre syndrome (GBS and its characteristic clinical features are ophthalmoplegia, ataxia, and areflexia. Typically, it is associated with anti-GQ1b antibodies; however, a significant percentage (>10% of these patients are seronegative. Here, we report a 67-year-old female patient who presented with the typical clinical features of MFS. Workup revealed antibodies against glutamic acid decarboxylase (GAD in relatively high titers while GQ1b antibodies were negative. Neurological improvement was observed after intravenous gamma globulin and follow-up examinations showed a continuous clinical amelioration with simultaneous decline of anti-GAD levels which finally returned to normal values. This case indicates that anti-GAD antibodies may be associated with a broader clinical spectrum and future studies in GQ1b-seronegative patients could determine ultimately their clinical and pathogenetic significance in this syndrome.

  16. Biometric analysis of the intestine of the Southern Caracara (Polyborus plancus, Miller, 1777

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    Carime Moraes

    2007-06-01

    Full Text Available This experiment investigated the biometric parameters for the enteric tract of eight Southern Caracaras (Polyborus plancus, Miller 1777. The study was carried out on eight adult animals of both sexes (four males and four females having different ages and weights. The animals were sacrificed and dissected, and their visceral tracts were placed on a horizontal plane surface. The lengths were measured and the weights were obtained on electronic precision scales. The statistical analysis utilized was Student’s t-test with a significance level p=0.05. The results showed that the Southern Caracara possessed a duodenum and an ileum longer than those of the chicken. It was concluded that the small intestine of the Southern Caracara is relatively extensive, mainly on account of the duodenum that is similar in length to that of the goose. This bird had a vestige of the cecum that it is different to that of the chicken.

  17. Teorema Modigliani-Miller, imperfetta informazione e meccanismo di trasmissione della politica monetaria

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    G. BERTOCCO

    1995-09-01

    Full Text Available The work first aims to show that the Modigliani-Miller theorem can not constitute the theoretical foundation of traditional analysis. It then analyses the consequences of the presence of imperfect information on the characteristics of the transmission mechanism of monetary policy. It is observed that the dependence on commercial bank credit is not a sufficient condition for operating a transmission mechanism based on the control of the amount of credit that is different from the traditional mechanism. If the banking system could isolate the supply of credit through central bank decisions, the effects of monetary policy would be transmitted through interest rates, as established traditional analysis. The author shows that the characteristics of the transmission mechanism of monetary policy do not depend only on the presence of imperfect information, but also on the assumptions regarding the determination of the supply of credit.

  18. Teorema Modigliani-Miller, imperfetta informazione e meccanismo di trasmissione della politica monetaria

    Directory of Open Access Journals (Sweden)

    G. BERTOCCO

    2013-10-01

    Full Text Available The work first aims to show that the Modigliani-Miller theorem can not constitute the theoretical foundation of traditional analysis. It then analyses the consequences of the presence of imperfect information on the characteristics of the transmission mechanism of monetary policy. It is observed that the dependence on commercial bank credit is not a sufficient condition for operating a transmission mechanism based on the control of the amount of credit that is different from the traditional mechanism. If the banking system could isolate the supply of credit through central bank decisions, the effects of monetary policy would be transmitted through interest rates, as established traditional analysis. The author shows that the characteristics of the transmission mechanism of monetary policy do not depend only on the presence of imperfect information, but also on the assumptions regarding the determination of the supply of credit.  JEL Codes: E52, G14

  19. Performance of Hispanic inmates on the Spanish Miller Forensic Assessment of Symptoms Test (M-FAST).

    Science.gov (United States)

    Montes, Orbelin; Guyton, Michelle R

    2014-10-01

    The few psychological assessment measures commercially available for the assessment of Spanish-speaking populations lack strong empirical foundation. This is concerning given the rising numbers of Spanish speakers entering the forensic and correctional systems for whom valid assessment is difficult without linguistically and culturally appropriate measures. In this study, we translated and adapted the Miller Forensic Assessment of Symptoms Test (M-FAST) into Spanish. The general purpose of this study was to investigate the psychometric, linguistic, and conceptual equivalence of the English- and Spanish-language versions of the M-FAST in a sample of 102 bilingual Hispanic incarcerated males. Participants were randomly assigned to one of three feigning conditions (honest, uncoached, or coached) and completed the M-FAST in both English and Spanish on two separate occasions. Both language versions were psychometrically, linguistically, and conceptually equivalent. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  20. Mycocoenology in Abies alba Miller woods of central-southern Tuscany (Italy

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    Angela Laganà

    2014-01-01

    Full Text Available Numerous reports indicate that fir woods in central and northern Europe have recently been damaged by increasing pollution. It has been demonstrated that fungi can be good bioindicators of forest health status. In polluted areas the production of fruit bodies generally declines and the fungal biodiversity, especially of symbiotic species, is reduced. Here we report the results of a survey of the fungal and plant communities in woods of Abies alba Miller in central-southern Tuscany, already studied in the past. Certain changes were observed in the study areas, but they seem more likely to be due to other factors than pollution, such as the weather conditions, the age and natural evolution of the forests towards their climax.

  1. Operations Manager Tim Miller checks out software for the Airborne Synthetic Aperature Radar (AIRSAR

    Science.gov (United States)

    1998-01-01

    Tim Miller checks out software for the Airborne Synthetic Aperture Radar (AIRSAR). He was the AIRSAR operations manager for NASA's Jet Propulsion Laboratory. The AIRSAR produces imaging data for a range of studies conducted by the DC-8. NASA is using a DC-8 aircraft as a flying science laboratory. The platform aircraft, based at NASA's Dryden Flight Research Center, Edwards, Calif., collects data for many experiments in support of scientific projects serving the world scientific community. Included in this community are NASA, federal, state, academic and foreign investigators. Data gathered by the DC-8 at flight altitude and by remote sensing have been used for scientific studies in archeology, ecology, geography, hydrology, meteorology, oceanography, volcanology, atmospheric chemistry, soil science and biology.

  2. Aleksei Miller ja "uus impeeriumi ajalugu" / Toomas Karjahärm

    Index Scriptorium Estoniae

    Karjahärm, Toomas, 1944-

    2011-01-01

    Arvustus: Миллер, Алексей. Империя Романовых и национализм : эссе по методологии исторического исследования. Москва : Новое Литературное Обозрение, 2008. (Historica Rossica). Polüetnilisi impeeriume eelistab Miller käsitleda mitte regionaalsete, vaid situatiivsete kategooriatega

  3. 5 YEAR PHYSIOTHERAPY AND REHABILITATION RESULTS OF THE PATIENT WITH MILLER FISHER SYNDROME

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    Bihter AKINOĞLU

    2016-08-01

    Full Text Available Background: Miller-Fisher syndrome (MFS is characterized by gait ataxia, external ophtalmoplegia and areflexia and thought as an uncommon variant of Guillain Barre syndrome. Miller-Fisher syndrome is observed in about 5-8% of all Guillain Barre syndrome (GBS cases. In MFS patients, spontaneous improvement was observed in the first 3 months and these improvements were started by the 2nd week. Methods: This case was referred to physiotherapy and rehabilitation program at the 4th week since the appropriate medical treatments were unsuccessful after the attack. The patient was evaluated generally before physiotherapy program, and muscle length, strength loss, deep tendon reflexes, postural impairments and daily difficult activities and positions were assessed. Besides, the desired daily activities were identified by The Canadian Occupational Performance Measure (COPM. Treatment program was adjusted according to the patient and changes during treatment period were observed. Physiotherapy program included classical physiotherapy methods: posture correction, correction of short muscles, muscle strengthening, flexibility increase, balance/coordination, sitting and standing functions and walking improvement and climbing up stairs. Results: After the treatment, lower extremity muscle shortness decreased and muscle strength, standing on one foot duration, independent walk speed increased in time. Before treatment, he could not climbing upstairs, but it was achieved 1 year after the treatment. Berg balance score increased in time and his most desired activities by COPM (10/10 were could be performed after the treatment. Conclusion: The case improved with physiotherapy and rehabilitation program gradually with years.In the treatment of MFS patients, physiotherapy and rehabilitation being part of the treatment will be useful.

  4. A Short Study on the Validity of Miller's Theorem Applied to Transistor Amplifier High-Frequency Performance

    Science.gov (United States)

    Schubert, T. F., Jr.; Kim, E. M.

    2009-01-01

    The use of Miller's Theorem in the determination of the high-frequency cutoff frequency of transistor amplifiers was recently challenged by a paper published in this TRANSACTIONS. Unfortunately, that paper provided no simulation or experimental results to bring credence to the challenge or to validate the alternate method of determination…

  5. Caracterização farmacognóstica da droga e do extrato fluido de Persea americana Miller

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    Marcia Aparecida Gutierrez

    Full Text Available As folhas de Persea americana Miller, conhecidas vulgarmente como folhas-de-abacate, foram caracterizadas morfológica e cromatograficamente. A presenga de anetol, estragol e cariofileno foram pesquisadas na droga brasileira. O extrato fluido foi caracterizado através de sua fração flavonóidica.

  6. Fire Frequency Effects on Longleaf Pine (Pinus palustris P. Miller) Vegetation in South Carolina and Northeast Florida, USA

    Science.gov (United States)

    Jeff S. Glitzenstein; Donna R. Streng; Dale D. Wade

    2003-01-01

    Southeastern United States habitats dominated by longleaf pine (Pinus pulutris P. Miller) have declined precipitously in area and extent. Conservation of diverse ground-layer vegetation in these endangered habitats depends on prescribed fire. While the need for prescribed fire is now generally accepted, there is disagreement concerning the most...

  7. Johannes Miller o výzdobě Auly olomoucké univerzity v letech 1718 - 1719

    Czech Academy of Sciences Publication Activity Database

    Dolejší, Kateřina

    -, č. 294 (2007), s. 81-84 ISSN 1212-1134 R&D Projects: GA ČR GA408/03/0059 Institutional research plan: CEZ:AV0Z80330511 Keywords : Baroque wall painting * Olomouc University * Johannes Miller Subject RIV: AL - Art, Architecture, Cultural Heritage

  8. A CLINICAL ASSESSMENT OF MACINTOSH BLADE, MILLER BLADE AND KING VISIONTM VIDEOLARYNGOSCOPE FOR LARYNGEAL EXPOSURE AND DIFFICULTY IN ENDOTRACHEAL INTUBATION

    Directory of Open Access Journals (Sweden)

    Apoorva Mahendera

    2016-03-01

    Full Text Available CONTEXT Previous studies suggest glottic view is better achieved with straight blades while tracheal intubation is easier with curved blades and videolaryngoscope is better than conventional laryngoscope. AIMS Comparison of conventional laryngoscope (Macintosh blade and Miller blade with channelled videolaryngoscope (King Vision TM with respect to laryngeal visualisation and difficulty in endotracheal intubation. SETTINGS AND DESIGN This prospective randomised comparative study was conducted at a tertiary care hospital (in ASA I and ASA II patients after approval from the Institutional Ethics Committee. METHODS We compared Macintosh, Miller, and the King VisionTM videolaryngoscope for glottic visualisation and ease of tracheal intubation. Patients undergoing elective surgeries under general anaesthesia requiring endotracheal intubation were randomly divided into three groups (N=180. After induction of anaesthesia, laryngoscopy was performed and trachea intubated. We recorded visualisation of glottis (Cormack-Lehane grade-CL, ease of intubation, number of attempts, need to change blade, and need for external laryngeal manipulation. STATISTICAL ANALYSIS Demographic data, Mandibular length, Mallampati classification were compared using ANOVA, Chi-square test, Kruskal-Wallis Test, where P value <0.005 is statically significant. RESULTS CL grade 1 was most often observed in King Vision -TM VL group (90% which is followed by Miller (28.33%, and Macintosh group (15%. We found intubation was to be easier (grade 1 with King Vision -TM VL group (73.33%, followed by Macintosh (38.33%, and Miller group (1.67%. External manipulation (BURP was needed more frequently in patients in Miller group (71.67%, followed by Macintosh (28.33% and in King Vision -TM VL group (6.67%. All (100% patients were intubated in the 1 st attempt with King Vision -TM VL group, followed by Macintosh group (90% and Miller group (58.33%. CONCLUSIONS In patients with normal airway

  9. A carbon-rich region in Miller Range 091004 and implications for ureilite petrogenesis

    Science.gov (United States)

    Day, James M. D.; Corder, Christopher A.; Cartigny, Pierre; Steele, Andrew M.; Assayag, Nelly; Rumble, Douglas; Taylor, Lawrence A.

    2017-02-01

    Ureilite meteorites are partially melted asteroidal-peridotite residues, or more rarely, cumulates that can contain greater than three weight percent carbon. Here we describe an exceptional C-rich lithology, composed of 34 modal % large (up to 0.8 mm long) crystalline graphite grains, in the Antarctic ureilite meteorite Miller Range (MIL) 091004. This C-rich lithology is embedded within a silicate region composed dominantly of granular olivine with lesser quantities of low-Ca pyroxene, and minor FeNi metal, high-Ca pyroxene, spinel, schreibersite and troilite. Petrological evidence indicates that the graphite was added after formation of the silicate region and melt depletion. Associated with graphite is localized reduction of host olivine (Fo88-89) to nearly pure forsterite (Fo99), which is associated with FeNi metal grains containing up to 11 wt.% Si. The main silicate region is typical of ureilite composition, with highly siderophile element (HSE) abundances ∼0.3 × chondrite, 187Os/188Os of 0.1260-0.1262 and Δ17O of -0.81 ± 0.16‰. Mineral trace-element analyses reveal that the rare earth elements (REE) and the HSE are controlled by pyroxene and FeNi metal phases in the meteorite, respectively. Modeling of bulk-rock REE and HSE abundances indicates that the main silicate region experienced ∼6% silicate and >50% sulfide melt extraction, which is at the lower end of partial melt removal estimated for ureilites. Miller Range 091004 demonstrates heterogeneous distribution of carbon at centimeter scales and a limited range in Mg/(Mg + Fe) compositions of silicate grain cores, despite significant quantities of carbon. These observations demonstrate that silicate rim reduction was a rapid disequilibrium process, and came after silicate and sulfide melt removal in MIL 091004. The petrography and mineral chemistry of MIL 091004 is permissive of the graphite representing late-stage C-rich melt that pervaded silicates, or carbon that acted as a lubricant during

  10. Antibacterial activity of endophytic fungi from leaves of Indigofera suffruticosa Miller (Fabaceae)

    Science.gov (United States)

    dos Santos, Irailton Prazeres; da Silva, Luís Cláudio Nascimento; da Silva, Márcia Vanusa; de Araújo, Janete Magali; Cavalcanti, Marilene da Silva; Lima, Vera Lucia de Menezes

    2015-01-01

    Endophytic fungi were isolated from healthy leaves of Indigofera suffruticosa Miller, a medicinal plant found in Brazil which is used in folk medicine to treat various diseases. Among 65 endophytic fungi isolated, 18 fungi showed activity against at least one tested microorganism in preliminary screening, and the best results were obtained with Nigrospora sphaerica (URM-6060) and Pestalotiopsis maculans (URM-6061). After fermentation in liquid media and in semisolid media, only N. sphaerica demonstrated antibacterial activity (in Potato Dextrose Broth-PDB and in semisolid rice culture medium). In the next step, a methanolic extract from rice culture medium (NsME) and an ethyl acetate extract (NsEAE) from the supernatant of PDB were prepared and both exhibited antimicrobial activity against Gram-negative and Gram-positive bacteria. The best result was observed against Staphylococcus aureus, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 1.56 mg/mL and 6.25 mg/mL, respectively, for NsME and MIC and MBC values of 0.39 mg/mL and 3.12 mg/mL, respectively, for NsEAE. This study is the first report about the antimicrobial activity of endophytic fungi residing in I. suffruticosa leaves, in which the fungus N. sphaerica demonstrated the ability to produce bioactive agents with pharmaceutical potential, and may provide a new lead in the pursuit of new biological sources of drug candidates. PMID:25999918

  11. Review of The Chicago Guide to Writing about Numbers by Jane E. Miller

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    Neil Lutsky

    2009-01-01

    Full Text Available Miller, J. E. 2004. The Chicago Guide to Writing about Numbers. Chicago, IL: University of Chicago Press. 304 pp. Cloth $45 ISBN: 9780226526300, Softcover $17. ISBN: 9780226526317.The Chicago Guide to Writing about Numbers is a reference work suitable for anyone interested in understanding, using, or promoting quantitative thinking. Its primary aim is to identify and illustrate ways in which information associated with numbers can be conveyed most effectively given a particular communication purpose and context. The book is directed at writers who incorporate numbers in verbal or visual displays in documents, in oral presentations, or on the Web. The Chicago Guide to Writing about Numbers identifies overarching principles, offers concrete advice, and presents illuminating examples and models. The book can be used for instructional purposes for undergraduates, and a means of doing so is described. The review concludes by considering the book’s contributions to a wider call to help citizens write or argue more effectively by using numbers.

  12. Pavlov's position toward Konorski and Miller's distinction between Pavlovian and motor conditioning paradigms.

    Science.gov (United States)

    Windholz, G; Wyrwicka, W

    1996-01-01

    Two Warsaw medical students, Jerzy Konorski and Stefan Miller, having read I.P. Pavlov's works on conditional reflexes, informed him in a 1928 letter that they had discovered a new type of conditioning. A previously neutral stimulus preceded the passive lifting of a dog's paw which then was followed by feeding; this stimulus then evoked the spontaneous raising of that paw. Pavlov responded informing them that their conditioning of motor responses expanded his theory of higher nervous activity, but that their conditioning paradigm-that they named CRII-did not differ fundamentally from the Pavlovian conditioning paradigm. The replication of the Warsaw experiment in Pavlov's laboratory failed to provide unequivocal results. From 1931 to 1933, Konorski, working in Pavlov's Leningrad laboratory, further explored the parameters of CRII. Pavlov insisted that the conditioning of motor movements differs from the conditioning of other sensory analyzers only in that, on the neural level, the motor analyzer is both afferent, that is, perceptive, and efferent, that is, responsive. Konorski was not convinced, and he subsequently maintained that the two conditioning paradigms were fundamentally different.

  13. Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats.

    Science.gov (United States)

    Coelho, Fernanda Hack; Salvadori, Gabriela; Rados, Pantelis Varvaki; Magnusson, Alessandra; Danilevicz, Chris Krebs; Meurer, Luise; Martins, Manoela Domingues

    2015-07-01

    The effect of topical application of Aloe Vera (Aloe barbadensis Miller) extract was assessed on the healing of rat oral wounds in an in vivo model using 72 male Wistar rats divided into three groups (n = 24): control, placebo and Aloe Vera (0.5% extract hydroalcoholic). Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool. The Aloe Vera and placebo group received two daily applications. The animals were sacrificed after 1, 5, 10 and 14 days. Clinical analysis (ulcer area and percentage of repair) and histopathological analysis (degree of re-epithelialization and inflammation) were performed. The comparison of the differences between scores based on group and experimental period, both in quantitative and semi-quantitative analyses, was performed using the Kruskal-Wallis test. The significance level was 5%. On day 1, all groups showed predominantly acute inflammatory infiltrate. On day 5, there was partial epithelialization and chronic inflammatory infiltrate. On the days 10 and 14 total repair of ulcers was observed. There was no significant difference between groups in the repair of mouth ulcers. It is concluded that treatment using Aloe Vera as an herbal formulation did not accelerate oral wound healing in rats. Copyright © 2015 John Wiley & Sons, Ltd.

  14. Amino Acids Generated from Hydrated Titan Tholins: Comparison with Miller-Urey Electric Discharge Products

    Science.gov (United States)

    Cleaves, H. James, II; Neish, Catherine; Callahan, Michael P.; Parker, Eric; Fernandez, Facundo M.; Dworkin, Jason P.

    2014-01-01

    Various analogues of Titan haze particles (termed tholins) have been made in the laboratory. In certain geologic environments on Titan, these haze particles may come into contact with aqueous ammonia (NH3) solutions, hydrolyzing them into molecules of astrobiological interest. A Titan tholin analogue hydrolyzed in aqueous NH3 at room temperature for 2.5 years was analyzed for amino acids using highly sensitive ultra-high performance liquid chromatography coupled with fluorescence detection and time-of-flight mass spectrometry (UHPLC-FDToF-MS) analysis after derivatization with a fluorescent tag. We compare here the amino acids produced from this reaction sequence with those generated from room temperature Miller-Urey (MU) type electric discharge reactions. We find that most of the amino acids detected in low temperature MU CH4N2H2O electric discharge reactions are generated in Titan simulation reactions, as well as in previous simulations of Triton chemistry. This argues that many processes provide very similar mixtures of amino acids, and possibly other types of organic compounds, in disparate environments, regardless of the order of hydration. Although it is unknown how life began, it is likely that given reducing conditions, similar materials were available throughout the early Solar System and throughout the universe to facilitate chemical evolution.

  15. Miller-Urey spark-discharge experiments in the deuterium world

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Geoffrey J.T.; Surman, Andrew J.; McIver, Jim; Colon-Santos, Stephanie M.; Gromski, Piotr S.; Buchwald, Saskia; Suarez Marina, Irene; Cronin, Leroy [WestCHEM, School of Chemistry, University of Glasgow (United Kingdom)

    2017-07-03

    We designed and conducted a series of primordial-soup Miller-Urey style experiments with deuterated gases and reagents to compare the spark-discharge products of a ''deuterated world'' with the standard reaction in the ''hydrogenated world''. While the deuteration of the system has little effect on the distribution of amino acid products, significant differences are seen in other regions of the product-space. Not only do we observe about 120 new species, we also see significant differences in their distribution if the two hydrogen isotope worlds are compared. Several isotopologue matches can be identified in both, but a large proportion of products have no equivalent in the corresponding isotope world with ca. 43 new species in the D world and ca. 39 new species in the H world. This shows that isotopic exchange (the addition of only one neutron) may lead to significant additional complexity in chemical space under otherwise identical reaction conditions. (copyright 2017 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA.)

  16. Changes in sugars, acids, and volatiles during ripening of koubo [Cereus peruvianus (L.) Miller] fruits.

    Science.gov (United States)

    Ninio, Racheli; Lewinsohn, Efraim; Mizrahi, Yosef; Sitrit, Yaron

    2003-01-29

    The columnar cactus Cereus peruvianus (L.) Miller, Cactaceae (koubo), is grown commercially in Israel. The unripe fruits are green, and the color changes to violet and then to red when the fruit is fully ripe. The content of soluble sugars was found to increase 5-fold during ripening. Glucose and fructose were the main sugars accumulated in the fruit pulp, and each increased from 0.5 to 5.5 g/100 g fresh weight during ripening. The polysaccharides content decreased during ripening from 1.4 to 0.4 g/100 g fresh weight. The titratable acidity decreased and the pH increased during ripening. The major organic acid found in the fruit was malic acid, which decreased from 0.75 g/100 g fresh weight at the mature green stage to 0.355 g/100 g fresh weight in ripe fruits. Citric, succinic, and oxalic acids were found in concentrations lower than 0.07 g/100 g fresh weight. Prominent accumulation of aroma volatiles occurred toward the end of the ripening process. The main volatile found in the ripe fruit was linalool, reaching concentrations of 1.5-3.5 microg/g fresh weight.

  17. Natural phosphodiesterase-4 inhibitors from the leaf skin of Aloe barbadensis Miller.

    Science.gov (United States)

    Zhong, Jia-Sheng; Huang, Yi-You; Zhang, Tian-Hua; Liu, Yu-Peng; Ding, Wen-Jing; Wu, Xiao-Fang; Xie, Zhi-Yong; Luo, Hai-Bin; Wan, Jin-Zhi

    2015-01-01

    The ethanolic extract of Aloe barbadensis Miller leaf skin showed inhibitory activity against phosphodiesterase-4D (PDE4D), which is a therapeutic target of inflammatory disease. Subsequent bioassay-guided fractionation led to the isolation of two new anthrones, 6'-O-acetyl-aloin B (9) and 6'-O-acetyl-aloin A (11), one new chromone, aloeresin K (8), together with thirteen known compounds. Their chemical structures were elucidated by spectroscopic methods including UV, IR, 1D and 2D NMR, and HRMS. All of the isolates were screened for their inhibitory activity against PDE4D using tritium-labeled adenosine 3',5'-cyclic monophosphate ((3)H-cAMP) as substrate. Compounds 13 and 14 were identified as PDE4D inhibitors, with their IC50 values of 9.25 and 4.42 μM, respectively. These achievements can provide evidences for the use of A. barbadensis leaf skin as functional feed additives for anti-inflammatory purpose. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. An Extension of the Miller Equilibrium Model into the X-Point Region

    Science.gov (United States)

    Hill, M. D.; King, R. W.; Stacey, W. M.

    2017-10-01

    The Miller equilibrium model has been extended to better model the flux surfaces in the outer region of the plasma and scrape-off layer, including the poloidally non-uniform flux surface expansion that occurs in the X-point region(s) of diverted tokamaks. Equations for elongation and triangularity are modified to include a poloidally varying component and grad-r, which is used in the calculation of the poloidal magnetic field, is rederived. Initial results suggest that strong quantitative agreement with experimental flux surface reconstructions and strong qualitative agreement with poloidal magnetic fields can be obtained using this model. Applications are discussed. A major new application is the automatic generation of the computation mesh in the plasma edge, scrape-off layer, plenum and divertor regions for use in the GTNEUT neutral particle transport code, enabling this powerful analysis code to be routinely run in experimental analyses. Work supported by US DOE under DE-FC02-04ER54698.

  19. Nutritive evaluation of a non-conventional leafy vegetable (Pereskia aculeata Miller).

    Science.gov (United States)

    Takeiti, Cristina Y; Antonio, Graziella C; Motta, Eliana M P; Collares-Queiroz, Fernanda P; Park, Kil J

    2009-01-01

    Pereskia aculeata Miller is a native cactus that can be found in Brazil and is called 'ora-pro-nobis' (OPN). Many people from poor communities consume the dark green leaves of OPN as a vegetable. The objective of the present work was to evaluate the nutritional components in terms of proximate composition, minerals, vitamins, protein content and their in vitro protein digestibility. OPN leaves showed remarkable levels of total dietary fiber (39.1% dry basis), minerals (calcium, magnesium, manganese and zinc) and vitamins (vitamin A, vitamin C and folic acid). Among amino acids, tryptophan was the most abundant (20.5% of the total amino acids) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed small peptides, inferior to 6.5 kDa, and four major bands (61 kDa, 53 kDa, 33 kDa, and 15 kDa). The protein digestibility corrected amino acid score showed the lowest value of sulfur-amino acids (Met+Cys). OPN leaves could be considered a good source of minerals, vitamins and amino acids, and may serve as a potential functional ingredient.

  20. Enhanced Synthesis of Alkyl Amino Acids in Miller's 1958 H2S Experiment

    Science.gov (United States)

    Parker, Eric T.; Cleaves, H. James; Callahan, Michael P.; Dworkin, James P.; Glavin, Daniel P.; Lazcano, Antonio; Bada, Jeffrey L.

    2011-01-01

    Stanley Miller's 1958 H2S-containing experiment, which included a simulated prebiotic atmosphere of methane (CH4), ammonia (NH3), carbon dioxide (CO2), and hydrogen sulfide (H2S) produced several alkyl amino acids, including the alpha-, beta-, and gamma-isomers of aminobutyric acid (ABA) in greater relative yields than had previously been reported from his spark discharge experiments. In the presence of H2S, aspariic and glutamic acids could yield alkyl amino acids via the formation of thioimide intermediates. Radical chemistry initiated by passing H2S through a spark discharge could have also enhanced alkyl amino acid synthesis by generating alkyl radicals that can help form the aldehyde and ketone precursors to these amino acids. We propose mechanisms that may have influenced the synthesis of certain amino acids in localized environments rich in H2S and lightning discharges, similar to conditions near volcanic systems on the early Earth, thus contributing to the prebiotic chemical inventory of the primordial Earth.

  1. The Microcosm within: An interview with William B. Miller, Jr., on the Extended Hologenome theory of evolution.

    Science.gov (United States)

    Hunt, Tam

    2015-01-01

    There is a singular unifying reality underlying every biologic interaction on our planet. In immunology, that which does not kill you makes you different. -William B. Miller, Jr. We are experiencing a revolution in our understanding of inner space on a par with our exponentially increasing understanding of outer space. In biology, we are learning that the genetic and epigenetic complexity within organisms is far deeper than suspected. This is a key theme in William B. Miller Jr.'s book, The Microcosm Within: Evolution and Extinction in the Hologenome. We are learning also that a focus on the human genome alone is misleading when it comes to who we really are as biological entities, and in terms of how we and other creatures have evolved. Rather than being defined by the human genome alone, we are instead defined by the "hologenome," the sum of the human genome and the far larger genetic endowment of the microbiome and symbiotic communities that reside within and around us. Miller is a medical doctor previously in private practice in Pennsylvania and Phoenix, Arizona. This book is his first foray into evolutionary theory. His book could have been titled "The Origin of Variation" because this is his primary focus. He accepts that natural selection plays a role in evolution, but he demotes this mechanism to a less important role than the Modern Synthesis suggests. His main gripe, however, concerns random variation. He argues that random variation is unable to explain the origin and evolution of biological forms that we see in the world around us and in the historical record. Miller suggests that, rather than random variation as the engine of novelty, there is a creative impulse at the heart of cellular life, and even at the level of the genetic aggregate, that generates novelty on a regular basis. I probe this assertion in the interview below. He also highlights the strong role of "exogenous genetic assault" in variation and in his immunological model of evolution.

  2. Prevention of Dental Damage and Improvement of Difficult Intubation Using a Paraglossal Technique With a Straight Miller Blade

    Directory of Open Access Journals (Sweden)

    Yu-Feng Huang

    2010-10-01

    Full Text Available Patients with diseased teeth, or those who are difficult to intubate, have a higher risk of dental injury during laryngoscopy. We report 3 cases of smooth endotracheal intubation using a paraglossal technique with a straight Miller blade in patients with poor dentition. Three patients with poor dentition were scheduled to undergo surgery under general anesthesia. All patients presented with extremely loose upper central incisors and had lost the other right upper teeth, while micrognathia and prominent, loose upper incisors were noted in 1 case. We elected to use a straight Miller blade using a paraglossal approach. A nasopharyngeal airway was inserted after induction of general anesthesia to facilitate mask ventilation and prevent air leakage from the mask. The Miller blade was then inserted from the right corner of the mouth, avoiding contact with the vulnerable incisors, and advanced along the groove between the tongue and tonsil. The endotracheal tube was subsequently smoothly inserted after obtaining a grade 1 Cormack and Lehane view without dental trauma in all 3 cases. Direct laryngoscopy using the paraglossal straight blade technique avoids dental damage in patients with mobile upper incisors and no right maxillary molars. It is a practical alternative method that differs from the traditional Macintosh laryngoscope in patients with a high risk of dental injury during the procedure. This technique, which provides an improved view of the larynx, might also be helpful with patients in whom intubation is difficult.

  3. Novel insights into the functional metabolic impact of an apparent de novo m.8993T>G variant in the MT-ATP6 gene associated with maternally inherited form of Leigh Syndrome.

    Science.gov (United States)

    Uittenbogaard, Martine; Brantner, Christine A; Fang, ZiShui; Wong, Lee-Jun C; Gropman, Andrea; Chiaramello, Anne

    2018-03-27

    In this study, we report a novel perpective of metabolic consequences for the m.8993T>G variant using fibroblasts from a proband with clinical symptoms compatible with Maternally Inherited Leigh Syndrome (MILS). Definitive diagnosis was corroborated by mitochondrial DNA testing for the pathogenic variant m.8993T>G in MT-ATP6 subunit by Sanger sequencing. The long-range PCR followed by massively parallel sequencing method detected the near homoplasmic m.8993T>G variant at 83% in the proband's fibroblasts and at 0.4% in the mother's fibroblasts. Our results are compatible with very low levels of germline heteroplasmy or an apparent de novo mutation. Our mitochondrial morphometric analysis reveals severe defects in mitochondrial cristae structure in the proband's fibroblasts. Our live-cell mitochondrial respiratory analyses show impaired oxidative phosphorylation with decreased spare respiratory capacity in response to energy stress in the proband's fibroblasts. We detected a diminished glycolysis with a lessened glycolytic capacity and reserve, revealing a stunted ability to switch to glycolysis upon full inhibition of OXPHOS activities. This dysregulated energy reprogramming results in a defective interplay between OXPHOS and glycolysis during an energy crisis. Our study sheds light on the potential pathophysiologic mechanism leading to chronic energy crisis in this MILS patient harboring the m.8993T>G variant. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex.

    Science.gov (United States)

    Arun, Vedant; Wiley, Joseph C; Kaur, Harpreet; Kaplan, David R; Guha, Abhijit

    2013-04-01

    Loss-of-function mutations and deletions in the neurofibromin tumor suppressor gene (NF1) cause neurofibromatosis type 1 (NF-1), the most common inherited syndrome of the nervous system in humans, with a birth incidence of 1:3,000. The most visible features of NF-1 are the neoplastic manifestations caused by the loss of Ras-GTPase-activating protein (Ras-GAP) activity mediated through the GAP-related domain (GRD) of neurofibromin (NF1), the protein encoded by NF1. However, the syndrome is also characterized by cognitive dysfunction and a number of developmental abnormalities. The molecular etiology of many of these nonneoplastic phenotypes remains unknown. Here we show that the tubulin-binding domain (TBD) of NF1 is a binding partner of the leucine-rich pentatricopeptide repeat motif-containing (LRPPRC) protein. These two proteins complex with Kinesin 5B, hnRNP A2, Staufen1, and Myelin Basic Protein (MBP) mRNA, likely in RNA granules. This interaction is of interest in that it links NF-1 with Leigh's syndrome, French Canadian variant (LSFC), an autosomal recessive neurodegenerative disorder that arises from mutations in the LRPPRC gene. Our findings provide clues to how loss or mutation of NF1 and LRPPRC may contribute to the manifestations of NF-1 and LSFC. Copyright © 2013 Wiley Periodicals, Inc.

  5. WATER TEMPERATURE and other data from NOAA Ship MILLER FREEMAN and NOAA Ship CHAPMAN from 1990-02-14 to 1990-06-27 (NODC Accession 9200046)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The depth data in this accession was collected as part of South Atlantic Ventilation Experiment (SAVE). The cruises were conducted using NOAA Ship MILLER FREEMAN and...

  6. Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits.

    NARCIS (Netherlands)

    M.A. de Klerk; H.P. Endtz (Hubert); B.C. Jacobs (Bart); J.D. Laman (Jon); F.G.A. van der Meché (Frans); P.A. van Doorn (Pieter); C.W. Ang (Wim)

    2001-01-01

    textabstractCampylobacter jejuni infections are thought to induce antiganglioside antibodies in patients with Guillain-Barre syndrome (GBS) and Miller Fisher syndrome (MFS) by molecular mimicry between C. jejuni lipopolysaccharides (LPS) and gangliosides. We used

  7. Thermodynamic performance analysis and optimization of DMC (Dual Miller Cycle) cogeneration system by considering exergetic performance coefficient and total exergy output criteria

    International Nuclear Information System (INIS)

    Ust, Yasin; Arslan, Feyyaz; Ozsari, Ibrahim; Cakir, Mehmet

    2015-01-01

    Miller cycle engines are one of the popular engine concepts that are available for improving performance, reducing fuel consumption and NO x emissions. There are many research studies that investigated the modification of existing conventional engines for operation on a Miller cycle. In this context, a comparative performance analysis and optimization based on exergetic performance criterion, total exergy output and exergy efficiency has been carried out for an irreversible Dual–Miller Cycle cogeneration system having finite-rate of heat transfer, heat leak and internal irreversibilities. The EPC (Exergetic Performance Coefficient) criterion defined as the ratio of total exergy output to the loss rate of availability. Performance analysis has been also extended to the Otto–Miller and Diesel-Miller cogeneration cycles which may be considered as two special cases of the Dual–Miller cycle. The effect of the design parameters such as compression ratio, pressure ratio, cut-off ratio, Miller cycle ratio, heat consumer temperature ratio, allocation ratio and the ratio of power to heat consumed have also been investigated. The results obtained from this paper will provide guidance for the design of Dual–Miller Cycle cogeneration system and can be used for selection of optimal design parameters. - Highlights: • A thermodynamic performance estimation tool for DM cogeneration cycle is presented. • Using the model two special cases OM and dM cogeneration cycles can be analyzed. • The effects of r M , ψ, χ 2 and R have been investigated. • The results evaluate exergy output and environmental aspects together.

  8. Organic Analysis in the Miller Range 090657 CR2 Chondrite: Part 2 Amino Acid Analyses

    Science.gov (United States)

    Burton, A. S.; Cao, T.; Nakamura-Messenger, K.; Berger, E. L.; Messenger, S.; Clemett, S. J.; Aponte, J. C.; Elsila, J. E.

    2016-01-01

    Primitive carbonaceous chondrites contain a wide variety of organic material, ranging from soluble discrete molecules to insoluble, unstructured kerogen-like components, as well as structured nano-globules of macromolecular carbon. The relationship between the soluble organic molecules, macromolecular organic material, and host minerals are poorly understood. Due to the differences in extractability of soluble and insoluble organic materials, the analysis methods for each differ and are often performed independently. The combination of soluble and insoluble analyses, when performed concurrently, can provide a wider understanding of spatial distribution, and elemental, structural and isotopic composition of organic material in primitive meteorites. Using macroscale extraction and analysis techniques in combination with in situ microscale observation, we have been studying both insoluble and soluble organic material in the primitive CR2 chondrite Miller Range (MIL) 090657. In accompanying abstracts (Cao et al. and Messenger et al.) we discuss insoluble organic material in the samples. By performing the consortium studies, we aim to improve our understanding of the relationship between the meteorite minerals and the soluble and insoluble organic phases and to delineate which species formed within the meteorite and those that formed in nebular or presolar environments. In this abstract, we present the results of amino acid analyses of MIL 090657 by ultra performance liquid chromatography with fluorescence detection and quadrupole-time of flight mass spectrometry. Amino acids are of interest because they are essential to life on Earth, and because they are present in sufficient structural, enantiomeric and isotopic diversity to allow insights into early solar system chemical processes. Furthermore, these are among the most isotopically anomalous species, yet at least some fraction are thought to have formed by aqueously-mediated processes during parent body alteration.

  9. Experimental measurements of plasma properties for Miller SG-100 torch with Mach I setting

    Energy Technology Data Exchange (ETDEWEB)

    Chen, W.L.T.; Heberlein, J.; Pfender, E. (Minnesota Univ., Minneapolis, MN (United States))

    1991-10-01

    In this work measurements of plasma properties, including the fields of temperature, velocity and plasma composition have been completed for the Miller SG-100 plasma torch using argon-helium mixtures with the Mach 1 nozzle at 1 atm pressure. A computer-controlled system combining both spectroscopic and enthalpy probe diagnostics has been developed to allow temperature measurements covering a range from 2000--16000K which includes the plasma flame region which is of interest. The experimental results expose the dominant effects in different spatial areas of argon-helium plasma jets. In the center near the nozzle exit the temperatures exceed 10,000K, and strong diffusion exists due to the steep radial gradients of temperature and particle number densities. In the jet tail region where the temperatures are well below 10,000K and decay in axial and radial direction, the dominant effects in this area are strong cold gas entrainment associated with turbulence. Substantial discrepancies between temperatures evaluated from spectroscopic and enthalpy probe data are particularly severe in the jet fringes indicating that strong deviations from LTE may exist in the jet fringes. In addition, entrainment of the cold surrounding gas into the plasma jet causes severe discrepancies between spectrometric and enthalpy probe data. The validity of the two diagnostic methods will be discussed. The temperature profiles in argon-helium plasma jets are flatter and wider, and the velocities are higher than in a pure argon plasma jet. These features of argon-helium plasma jets may be beneficial for obtaining better performance in the plasma spraying process. 26 refs., 28 figs., 2 tabs.

  10. On the adiabatic representation of Meyer-Miller electronic-nuclear dynamics.

    Science.gov (United States)

    Cotton, Stephen J; Liang, Ruibin; Miller, William H

    2017-08-14

    The Meyer-Miller (MM) classical vibronic (electronic + nuclear) Hamiltonian for electronically non-adiabatic dynamics-as used, for example, with the recently developed symmetrical quasiclassical (SQC) windowing model-can be written in either a diabatic or an adiabatic representation of the electronic degrees of freedom, the two being a canonical transformation of each other, thus giving the same dynamics. Although most recent applications of this SQC/MM approach have been carried out in the diabatic representation-because most of the benchmark model problems that have exact quantum results available for comparison are typically defined in a diabatic representation-it will typically be much more convenient to work in the adiabatic representation, e.g., when using Born-Oppenheimer potential energy surfaces (PESs) and derivative couplings that come from electronic structure calculations. The canonical equations of motion (EOMs) (i.e., Hamilton's equations) that come from the adiabatic MM Hamiltonian, however, in addition to the common first-derivative couplings, also involve second-derivative non-adiabatic coupling terms (as does the quantum Schrödinger equation), and the latter are considerably more difficult to calculate. This paper thus revisits the adiabatic version of the MM Hamiltonian and describes a modification of the classical adiabatic EOMs that are entirely equivalent to Hamilton's equations but that do not involve the second-derivative couplings. The second-derivative coupling terms have not been neglected; they simply do not appear in these modified adiabatic EOMs. This means that SQC/MM calculations can be carried out in the adiabatic representation, without approximation, needing only the PESs and the first-derivative coupling elements. The results of example SQC/MM calculations are presented, which illustrate this point, and also the fact that simply neglecting the second-derivative couplings in Hamilton's equations (and presumably also in the Schr

  11. Chemical composition and antibacterial activity of Pinus halepensis Miller growing in West Northern of Algeria

    Directory of Open Access Journals (Sweden)

    Nadia Fekih

    2014-04-01

    Full Text Available Objective: To find new bioactive natural products, the chemical composition and to sudy the antibacterial activity of essential oil components extracted from the aerial parts of the Algerian aromatic plant Pinus halepensis Miller (P. halepensis (needles, twigs and buds. Methods: The essential oil used in this study was isolated by hydrodistillation using a Clevenger-type apparatus according to the European Pharmacopoeia. The chemical composition was investigated using GC-retention indices (RI and GC-MS. Results: Forty-nine compounds, representing 97.9% of the total collective oil, were identified. Essential oil was dominated by hydrocarbon compounds (80.6% especially monoterpenes (65.5%. The major compounds from ten oils stations were: myrcene (15.2%-32.0%, α-pinene (12.2%- 24.5%, E-β-caryophyllene (7.0%-17.1%, terpinolene (1.8%-13.3%, 2-phenyl ethyl isovalerate (4.8%-10.9%, terpinene-4-ol (1.0%-8.2 % and sabinene (1.5%-6.3%. The intra-species variations of the chemical compositions of P. halepensis aerial parts essential oils from ten Algerian sample locations were investigated using statistical analysis. Essential oil samples were clustered in 2 groups by hierarchical cluster analysis, according to their chemical composition. The essential oil revealed an interesting antimicrobial effect against Lysteria monocytogenes, Enterococcus faecalis, Pseudomonas aeruginosa, Acinetobacter baumanii, Citrobacter freundii and Klebsiella pneumoniae. Conclusions: These results suggest that the essential oil from P. halepensis may be a new potential source as natural antimicrobial applied in pharmaceutical and food industries.

  12. Structural Modifications of Fructans in Aloe barbadensis Miller (Aloe Vera) Grown under Water Stress.

    Science.gov (United States)

    Salinas, Carlos; Handford, Michael; Pauly, Markus; Dupree, Paul; Cardemil, Liliana

    2016-01-01

    Aloe barbadensis Miller (Aloe vera) has a Crassulaceae acid metabolism which grants the plant great tolerance to water restrictions. Carbohydrates such as acemannans and fructans are among the molecules responsible for tolerating water deficit in other plant species. Nevertheless, fructans, which are prebiotic compounds, have not been described nor studied in Aloe vera, whose leaf gel is known to possess beneficial pharmaceutical, nutritional and cosmetic properties. As Aloe vera is frequently cultivated in semi-arid conditions, like those found in northern Chile, we investigated the effect of water deficit on fructan composition and structure. For this, plants were subjected to different irrigation regimes of 100%, 75%, 50% and 25% field capacity (FC). There was a significant increase in the total sugars, soluble sugars and oligo and polyfructans in plants subjected to water deficit, compared to the control condition (100% FC) in both leaf tips and bases. The amounts of fructans were also greater in the bases compared to the leaf tips in all water treatments. Fructans also increase in degree of polymerization with increasing water deficit. Glycosidic linkage analyses by GC-MS, led to the conclusion that there are structural differences between the fructans present in the leaves of control plants with respect to plants irrigated with 50% and 25% FC. Therefore, in non-stressed plants, the inulin, neo-inulin and neo-levan type of fructans predominate, while in the most stressful conditions for the plant, Aloe vera also synthesizes fructans with a more branched structure, the neofructans. To our knowledge, the synthesis and the protective role of neo-fructans under extreme water deficit has not been previously reported.

  13. Structural Modifications of Fructans in Aloe barbadensis Miller (Aloe Vera Grown under Water Stress.

    Directory of Open Access Journals (Sweden)

    Carlos Salinas

    Full Text Available Aloe barbadensis Miller (Aloe vera has a Crassulaceae acid metabolism which grants the plant great tolerance to water restrictions. Carbohydrates such as acemannans and fructans are among the molecules responsible for tolerating water deficit in other plant species. Nevertheless, fructans, which are prebiotic compounds, have not been described nor studied in Aloe vera, whose leaf gel is known to possess beneficial pharmaceutical, nutritional and cosmetic properties. As Aloe vera is frequently cultivated in semi-arid conditions, like those found in northern Chile, we investigated the effect of water deficit on fructan composition and structure. For this, plants were subjected to different irrigation regimes of 100%, 75%, 50% and 25% field capacity (FC. There was a significant increase in the total sugars, soluble sugars and oligo and polyfructans in plants subjected to water deficit, compared to the control condition (100% FC in both leaf tips and bases. The amounts of fructans were also greater in the bases compared to the leaf tips in all water treatments. Fructans also increase in degree of polymerization with increasing water deficit. Glycosidic linkage analyses by GC-MS, led to the conclusion that there are structural differences between the fructans present in the leaves of control plants with respect to plants irrigated with 50% and 25% FC. Therefore, in non-stressed plants, the inulin, neo-inulin and neo-levan type of fructans predominate, while in the most stressful conditions for the plant, Aloe vera also synthesizes fructans with a more branched structure, the neofructans. To our knowledge, the synthesis and the protective role of neo-fructans under extreme water deficit has not been previously reported.

  14. Calculation of autoionization positions and widths with applications to Penning ionization reactions. [Miller golden rule formula

    Energy Technology Data Exchange (ETDEWEB)

    Isaacson, A.D.

    1978-08-01

    Using an approximate evaluation of Miller's golden rule formula to calculate autoionization widths which allows for the consideration only of L/sup 2/ functions, the positions and lifetimes of the lowest /sup 1/,/sup 3/P autoionizing states of He have been obtained to reasonable accuracy. This method has been extended to molecular problems, and the ab initio configuration interaction potential energy and width surfaces for the He(2/sup 3/S) + H/sub 2/ system have been obtained. Quantum mechanical close-coupling calculations of ionization cross sections using the complex V* - (i/2) GAMMA-potential have yielded rate constants in good agreement with the experimental results of Lindinger, et al. The potential energy surface of the He(2/sup 1/S) + H/sub 2/ system has also been obtained and exhibits not only a high degree of anisotropy, but also contains a relative maximum for a perpendicular (C/sub 2//sub v/) approach which appears to arise from s-p hybridization of the outer He orbital. However, similar ab initio calculations on the He(2/sup 1/S) + Ar system do not show such anomalous structure. In addition, the complex poles of the S-matrix (Siegert eigenvalues) were calculated for several autoionizing states of He and H/sup -/, with encouraging results even for quite modest basis sets. This method was extended to molecular problems, and results obtained for the He(2/sup 3/S) + H and He(2/sup 1/S) + H systems. 75 references.

  15. Bookshelf (Early Quantum Electrodynamics - A Source Book, by Arthur I. Miller)

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Many people these days would say that quantum electrodynamics, the quantum picture of electromagnetic radiation, dates from 1947-8 with the work of Sin-itoro Tomonaga, Julian Schwinger and Richard Feynman. However this was the modern reformulation of a theory whose genesis was Paul Dirac's 1927 work on the quantization of radiation and was subsequently, and painfully, pieced together in the 1930s. Until the Second World War, the science of quantum electrodynamics advanced steadily, driven for the most part by the intellects which had produced modern quantum mechanics - notably Dirac, Heisenberg and Pauli. After Dirac's 1928 relativistic theory of the electron, Heisenberg and Pauli went on to cast an initial quantum formalism for the interaction between radiation and electrons. During this time many intellectual hurdles had to be crossed - the negative energy states predicted by Dirac's equation and their final identification as antimatter electrons (positrons), the whole problem of explaining quantum force mechanisms as particle exchanges, Fermi's explanation of beta decay, and Yukawa's explanation of the nuclear force. Heisenberg's invention of the S-matrix and his ideas on the transmission of nuclear forces through exchange mechanisms revolutionized both our picture of the quantum world. These problems were not easy - several times during the 1920s even these intellects almost despaired. A shadow across the subject was the continual problem of troublesome infinities in mass terms and elsewhere. It was not until the ordered renormalization recipes of the immediate post-war period that these infinities were finally hidden from sight. Science historian Arthur Miller traces these developments in the first half of the book, and signals how these early developments were eventually to dovetail with the exciting new developments of the late 1940s. Supplementing the survey are eleven fascinating landmark papers by Heisenberg, Dirac, Weisskopf

  16. Effect of turbo charging and steam injection methods on the performance of a Miller cycle diesel engine (MCDE)

    International Nuclear Information System (INIS)

    Gonca, Guven; Sahin, Bahri

    2017-01-01

    Highlights: • Performance of a diesel engine is simulated by finite time thermodynamics. • Effect of steam injection on performance of a Miller cycle engine is examined. • Model results are verified with the experimental data with less than 7% error. - Abstract: In this study, application of the steam injection method (SIM), Miller cycle (MC) and turbo charging (TC) techniques into a four stroke, direct-injection diesel engine has been numerically and empirically conducted. NOx emissions have detrimental influences on the environment and living beings. They are formed at the high temperatures, thus the Diesel engines are serious NOx generation sources since they have higher compression ratios and higher combustion temperatures. The international regulations have decreased the emission limits due to environmental reasons. The Miller cycle (MC) application and steam injection method (SIM) have been popular to abate NOx produced from the internal combustion engines (ICEs), in the recent years. However, the MC application can cause a reduction in power output. The most known technique which maximizes the engine power and abates exhaust emissions is TC. Therefore, if these three techniques are combined, the power loss can be tolerated and pollutant emissions can be minimized. While the application of the MC and SIM causes to diminish in the brake power and brake thermal efficiency of the engine up to 6.5% and 10%, the TC increases the brake power and brake thermal efficiency of the engine up to 18% and 12%. The experimental and theoretical results have been compared in terms of the torque, the specific fuel consumption (SFC), the brake power and the brake thermal efficiency. The results acquired from theoretical modeling have been validated with empirical data with less than 7% maximum error. The results showed that developed combination can increase the engine performance and the method can be easily applied to the Diesel engines.

  17. Los costos de la desinflación en Colombia según el modelo Buiter-Miller

    Directory of Open Access Journals (Sweden)

    Ramírez Vigoya Alejandro

    2005-12-01

    Full Text Available En este artículo analizamos los costos del proceso desinflacionario colombiano entre 1998 y 2003, utilizamos un modelo VAR estructural con restricciones de corto y largo plazo basado en el modelo Buiter-Miller (1982, el cual analiza los efectos de una desaceleración del crecimiento monetario sobre la tasa de interés real, la tasa de cambio real, la producción y los precios. Por medio de la contabilidad de innovaciones concluimos que los choques de la tasa de interés real y del crecimiento de la base monetaria fueron los principales causantes de la desinflación.

  18. Steven E. Miller and Dmitri V. Trenin, eds., The Russian Military: Power and Policy, Cambridge, MA: MIT Press, 2004.

    Directory of Open Access Journals (Sweden)

    Mikhail Tsypkin

    2005-10-01

    Full Text Available The Russian military largely went below the radar of Western interest after the disintegration of the Soviet Union.  More than a decade after the creation of the Armed Forces of the Russian Federation, they have become again the object of interest for scholars – this time, both Western and Russian, as demonstrated by the reviewed volume, whose editors assembled a group of extraordinarily knowledgeable experts from Russia and the West.  In his introduction, Steven Miller explains that the purp...

  19. An Optimization Study on an Eco-Friendly Engine Cycle Named as Dual-Miller Cycle (DMC for Marine Vehicles

    Directory of Open Access Journals (Sweden)

    Gonca Guven

    2017-09-01

    Full Text Available The diesel engine is an indispensable part of technology and it is commonly used in land and marine vehicles. However, diesel engines release NOx emissions due to high combustion temperatures. They have harmful effects on the environment such as sources of photo-chemical fog and climate changes. Therefore, they must be reduced and limited. The Miller cycle application is a NOx control method and it is popular in the recent years to abate NOx produced from the internal combustion engines (ICEs. A performance investigation of a Dual-Miller cycle (DMC engine in terms of power (PO, power density (PD and effective efficiency (EE has been performed using a new finite-time thermodynamics modeling (FTTM in this study. The effects of engine design and operating parameters on the engine performance (EPER have been examined. Additionally, the energy losses have been determined resulting from incomplete combustion (IC, friction (FR, heat transfer (HT and exhaust output (EO. The results presented could be an essential tool for DMC marine engine designers.

  20. Primordial Synthesis of Amines and Amino Acids in a 1958 Miller H2S-Rich Spark Discharge Experiment

    Science.gov (United States)

    Parker, Eric T.; Cleaves, Henderson J.; Dworkin, Jason P.; Glavin, Daniel P.; Callahan, Michael; Aubrey, Andrew; Lazcano, Antonio; Bada, Jeffrey L.

    2011-01-01

    Archived samples from a previously unreported 1958 Stanley Miller electric discharge experiment containing hydrogen sulfide (H2S) were recently discovered and analyzed using high-performance liquid chromatography and time-of-flight mass spectrometry. We report here the detection and quantification of primary amine-containing compounds in the original sample residues, which were produced via spark discharge using a gaseous mixture of H2S, CH4, NH3, and CO2. A total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples. The major amino acids with chiral centers are racemic within the accuracy of the measurements, indicating that they are not contaminants introduced during sample storage. This experiment marks the first synthesis of sulfur amino acids from spark discharge experiments designed to imitate primordia! environments. The relative yield of some amino acids, in particular the isomers of aminobutyric acid, are the highest ever found in a spark discharge experiment. The simulated primordial conditions used by Miller may serve as a model for early volcanic plume chemistry and provide insight to the possible roles such plumes may have played in abiotic organic synthesis. Additionally, the overall abundances of the synthesized amino acids in the presence of H2S are very similar to the abundances found in some carbonaceous meteorites, suggesting that H2S may have played an important role in prebiotic reactions in early solar system environments.

  1. Comparative evaluation of platelet-rich fibrin with connective tissue grafts in the treatment of miller's Class I gingival recessions

    Directory of Open Access Journals (Sweden)

    Sonam Mufti

    2017-01-01

    Full Text Available Background: One of the most common aesthetic problem encountered in the field of periodontology is gingival recession, which is, perceived by the patients as increase in length of teeth. The treatment of buccal gingival recession is a common requirement due to aesthetic concern or root sensitivity. This study was planned to evaluate the efficacy of PRF membrane compared to that of CTG in Miller's class I gingival recessions. Materials and Methods: 32 sites with Miller's Class I gingival recessions, out of which 16 sites received PRF (test and 16 sites received CTG (control. Each patient had undergone an initial periodontal treatment, including oral hygiene instructions, plaque control, and scaling and root planing, followed by re-evaluation. All clinical recordings; recession height, recession width, clinical attachment level, height of keratinized tissue, thickness of keratinized tissue, healing index and pain perception, were performed immediately before surgery (baseline and after 6 months interval following periodontal surgery. Results: In the test group, significant improvement was seen in terms CAL, REC-HT, REC-WD, HKT and TKT from baseline to 6 months. In the control group, only significant improvement seen was in REC-HT and TKT from baseline to 6 months. Comparison of both Healing Index and VAS score was done and it showed no significant difference between test and the control group except VAS at 1 week. Conclusion: Though CTG is a gold standard procedure, PRF can be used as an alternative procedure by keeping patient's comfort and recognition in mind.

  2. CERN Library | Arthur I. Miller presents "Colliding worlds: How Cutting-Edge Science Is Redefining Contemporary Art" | 21 October

    CERN Multimedia

    2014-01-01

    In recent decades, an exciting new art movement has emerged in which artists illuminate the latest advances in science.   Some of their provocative creations - a live rabbit implanted with the fluorescent gene of a jellyfish, a gigantic glass-and-chrome sculpture of the Big Bang itself - can be seen in traditional art museums and magazines, while others are being made by leading designers at Pixar, Google's Creative Lab and the MIT Media Lab. Arthur I. Miller takes readers on a wild journey to explore this new frontier. From the movement's origins a century ago - when Einstein shaped Cubism and X-rays affected fine photography - to the latest discoveries of biotechnology, cosmology and quantum physics, Miller shows how today's artists and designers are producing work at the cutting edge of science. Tuesday, 21 October 2014 at 14:30 in the Library, Bldg. 52 1-052 https://indico.cern.ch/event/346299/ *Coffee will be served from 2 p.m.* "Colliding Worlds: How Cutt...

  3. ESTUDO DA GERMINAÇÃO DE SEMENTES DE LAVANDA (Lavandula angustifolia Miller

    Directory of Open Access Journals (Sweden)

    E.M. AOYAMA

    1996-05-01

    Full Text Available Com o objetivo de estudar os efeitos do ácido giberélico, do efeito luz/escuro e do pré-resfriamento sobre a germinação de sementes de lavanda (Lavandula angustifolia Miller, empregou-se o delineamento experimental inteiramente casualizado, com cinco repetições de 30 sementes cada, e os seguintes tratamentos: testemunha; GA3 100 ppm; GA3 200 ppm; escuro; GA3 100 e 200 ppm + 48 h de pré-resfriamento e GA3 100 e 200 ppm + 7 dias de pré-resfriamento. As sementes de lavanda foram pré-embebidas por 18 horas nas soluções de GA3 e em água destilada e depois colocadas em gerbox, com papel de filtro umedecido com água destilada. Nos tratamentos com pré-resfriamento as sementes foram mantidas em câmara fria por 48 horas e 7 dias à temperatura de 5° C; posteriormente, foram transferidas para o germinador, sob luz branca contínua à temperatura constante de 25°C. A contagem das sementes foi realizada de 2 em 2 dias até completar 30 dias de teste. Para a avaliação dos efeitos dos tratamentos sobre a germinação das sementes foram realizadas as seguintes observações: a porcentagem de sementes germinadas e b tempo médio de germinação (expresso em dias. A partir dos resultados obtidos pode-se verificar que os tratamentos com GA3, em conjunto ou não com pré-resfriamento, aumentaram significativamente a porcentagem de germinação, além de acelerar tal processo.To study the effects of gibbellic acid, of the light/darkness and of pre-freezing on the germination of lavender seeds, a randomized experiment was used, with five replications of 30 seeds, with the following treatments: control, GA3 100 ppm, GA3 200 ppm, darkness, GA3 100 and 200 ppm + 48 h pre-freezing and GA3 100 and 200 ppm + 7 days of pre-freezing. The lavender seeds were pre-soaked during 18 hours in GA3 and destilated water solutions, and thereafter placed in gerbox, using moistened filter paper. In the pre-freezing treatments the seeds were kept in a refrigerator for

  4. A comparison between Miller and five-stroke cycles for enabling deeply downsized, highly boosted, spark-ignition engines with ultra expansion

    International Nuclear Information System (INIS)

    Li, Tie; Wang, Bin; Zheng, Bin

    2016-01-01

    Highlights: • Deeply downsized, highly boosted SI engine with ultra-expansion cycle is studied. • The Miller and five stroke cycles are compared on BSFC improvements and WOT performance. • The mechanism of fuel conversion efficiency improvement at various loads is discussed. • Performance of the two-stage boosting system for the downsized SI engine is investigated. • A unique strategy using the bypass for the five-stroke engine is proposed. - Abstract: It has been well known that the engine downsizing combined with intake boosting is an effective way to improve the fuel conversion efficiency without penalizing the engine torque performance. However, the potential of engine downsizing is not yet fully explored, and the major hurdles include the knocking combustion and the pre-turbine temperature limit, owing to the aggressive intake boosting. Using the engine cycle simulation, this paper compares the effects of the Miller and five stroke cycles on the performance of the deeply downsized and highly boosted SI engine, taking the engine knock and pre-turbine temperature into consideration. In the simulation, the downsizing is implemented by reducing the combustion cylinder number from four to two, while a two stage boosting system is designed for the deeply downsized engine to ensure the wide-open-throttle (WOT) performance comparable to the original four cylinder engine. The Miller cycle is realized by varying the intake valve timing and lift, while the five stroke cycle is enabled with addition of an extra expansion cylinder between the two combustion cylinders. After calibration and validation of the engine cycle simulation models using the experimental data in the original engine, the performances of the deeply downsized engines with both the Miller and five stroke cycles are numerically studied. For the most frequently operated points on the torque-speed map, at low loads the Miller cycle exhibits superior performance over the five-stroke cycle in terms

  5. Nicotine promotes rooting in leaf explants of in vitro raised seedlings of tomato, Lycopersicon esculentum Miller var. Pusa Ruby.

    Science.gov (United States)

    Bamel, Kiran; Gupta, Rajendra; Gupta, Shrish C

    2015-11-01

    Nicotine promotes rooting in leaf explants of tomato (Lycopersicon esculentum Miller var. Pusa Ruby). Nicotine at 10(-9) to 10(-3) M concentrations was added to the MS basal medium. The optimum response (three-fold increase in rooting) was obtained at 10(-7) M nicotine-enriched MS medium. At the same level i.e. 10(-7) M Nicotine induced dramatic increase (11-fold) in the number of secondary roots per root. We have shown earlier that exogenous acetylcholine induces a similar response in tomato leaves. Since nicotine is an agonist of one of the two acetylcholine receptors in animals, its ability to simulate ACh action in a plant system suggests the presence of the same molecular mechanism operative in both, animal and plant cells. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Risk and efficacy of human-enabled interspecific hybridization for climate-change adaptation: Response to Hamilton and Miller (2016)

    Science.gov (United States)

    Kovach, Ryan P.; Luikart, Gordon; Lowe, Winsor H.; Boyer, Matthew C.; Muhlfeld, Clint C.

    2016-01-01

    Hamilton and Miller (2016) provide an interesting and provocative discussion of how hybridization and introgression can promote evolutionary potential in the face of climate change. They argue that hybridization—mating between individuals from genetically distinct populations—can alleviate inbreeding depression and promote adaptive introgression and evolutionary rescue. We agree that deliberate intraspecific hybridization (mating between individuals of the same species) is an underused management tool for increasing fitness in inbred populations (i.e., genetic rescue; Frankham 2015; Whiteley et al. 2015). The potential risks and benefits of assisted gene flow have been discussed in the literature, and an emerging consensus suggests that mating between populations isolated for approximately 50–100 generations can benefit fitness, often with a minor risk of outbreeding depression (Frankham et al. 2011; Aitken & Whitlock 2013; Allendorf et al. 2013).

  7. Laterally positioned flap-revised technique along with platelet rich fibrin in the management of Miller class II gingival recession

    Directory of Open Access Journals (Sweden)

    Jagmohan Singh

    2013-01-01

    Full Text Available Gingival recession is a complex phenomenon that may present numerous therapeutic challenges to the clinician. The laterally positioned flap is commonly used to cover isolated, denuded roots that have adequate donor tissue laterally and vestibular depth. Various modifications in laterally sliding flap have been proposed in order to avoid the reported undesirable results on the donor teeth. Recently, use of growth factors has been proposed in combination with surgical techniques. This article highlights the use of laterally positioned pedicle flap-revised technique as a modification of laterally sliding flap technique along with autologous suspension of growth factors, platelet rich fibrin membrane (PRF for the management of localized Miller class-II gingival recession. After 6 months of follow-up, the clinical condition was stable with 80% root coverage and satisfactory gingival tissue healing at both donor and recipient site with no signs of inflammation. An excellent esthetical outcome was achieved and the patient was satisfied with case resolution.

  8. La financiación de las empresas en las perspectivas de Modigliani-Miller y Williamson

    Directory of Open Access Journals (Sweden)

    González Jorge Iván

    2003-12-01

    Full Text Available El artículo compara las visiones que tienen Modigliani-Miller y Williamson sobre los modos de financiación de las empresas (acciones y deuda. Mientras que para los primeros las alternativas de financiación son instrumentos técnicos, para Williamson son el reflejo de estructuras de gobernabilidad diferentes. Después de presentar las líneas generales de cada enfoque, el artículo muestra sus implicaciones analíticas. La teoría institucional de Williamson amplía el horizonte porque, de una parte, muestra que la economía tiene que dialogar con otras disciplina y, de otra, pone en evidencia el vínculo entre la decisión financiera y la gobernabilidad de la empresa.

  9. A new species of Hepatozoon Miller, 1908 (Apicomplexa: Adelerina) from the snake Philodryas nattereri Steindachner (Squamata: Dipsadidae) in northeastern Brazil.

    Science.gov (United States)

    Borges-Nojosa, Diva M; Borges-Leite, M Juliana; Maia, João P; Zanchi-Silva, Djan; da Rocha Braga, Roberta; Harris, D James

    2017-01-01

    Based on both unique morphological characteristics of the gamont, distinct changes caused to the host erythrocyte and analysis of partial 18S rRNA gene sequences, a new parasite of the genus Hepatozoon Miller, 1908 is described from the snake Philodryas nattereri Steindachner (Squamata: Dipsadidae) in northeastern Brazil. The new species, Hepatozoon musa n. sp., is characterized by large and curved mature gamonts (18.9 ± 0.9 μm in length and 3.8 ± 0.3 μm in width) that considerably engorge infected host erythrocytes and displace the nucleus laterally, which become longer and thinner. Phylogenetic estimates indicate the new species is more closely related to the recently described Hepatozoon cuestensis O'Dwyer, Moço, Paduan, Spenassatto, Silva & Ribolla, 2013, from Brazilian rattlesnakes. These recent findings highlight the need for further studies of Hepatozoon to better determine the biodiversity of this common but poorly-studied parasite group.

  10. A new microduplication syndrome encompassing the region of the Miller-Dieker (17p13 deletion) syndrome

    DEFF Research Database (Denmark)

    Roos, L; Jønch, A E; Kjaergaard, S

    2009-01-01

    BACKGROUND: The use of array comparative genome hybridisation (CGH) analyses for investigation of children with mental retardation has led to the identification of a growing number of new microdeletion and microduplication syndromes, some of which have become clinically well characterised and some...... that await further delineation. This report describes three children with de novo 17p13.1 duplications encompassing the PAFAH1B1 gene, who had similar phenotypic features, including mild to moderate developmental delay, hypotonia and facial dysmorphism, and compares them to the few previously reported cases...... to patients with deletion of the region (Miller-Dieker syndrome) the patients reported here had mild to moderate retardation and displayed no lissencephaly or gross brain malformations. Further cases with similar duplications are expected to be diagnosed, and will contribute to the delineation of a potential...

  11. The Genyornis Egg: Response to Miller et al.'s commentary on Grellet-Tinner et al., 2016

    Science.gov (United States)

    Grellet-Tinner, Gerald; Spooner, Nigel A.; Handley, Warren D.; Worthy, Trevor H.

    2017-04-01

    Williams (1981) and Williams and Rich (1991) attributed Australian Quaternary fossil eggshell that differed from that of emu Dromaius novaehollandiae to the extinct bird Genyornis newtoni without any osteological or embryonic support. Such association by proximity or abundance mirrors the case of the mistaken association of oviraptor eggs to Protoceratops in the 1920's by Andrews (Grellet-Tinner and Makovicky, 2006). No other candidate species was considered, and this attribution has been unchallenged and followed by everyone thereafter. Much research has been done on this Australian eggshell, with one result being that the extinction of the parent of this eggshell is the most well documented for a taxon in Australia (e.g., Miller et al., 1999, 2005). Grellet-Tinner et al. (2016) raised several problems with the identity of the eggshell Williams (1981) attributed to Genyornis newtoni and suggested that extinct megapodes of the genus Progura were the more likely layer of this eggshell type, therein referred to as ;putative Genyornis oological material; (PGOM). Miller et al. (2017) challenged our hypothesis stating that ;Based on the dimensions of the reconstructed Spooner Egg,Grellet-Tinner et al. (2016)argue that PGOM is too small for a bird with the body mass estimated for Genyornis (168-275 kg) … …[and] …. None of the additional PGOM observations reported byGrellet-Tinner et al. (2016)are inconsistent with a Genyornis parent;. Here we take the opportunity to respond to their critique, the basis of which resolves into a few points, which we address in turn.

  12. Quantitative analysis of Miller mobility index for the diagnosis of moderate to severe periodontitis - A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Chung-Ping Wu

    2018-03-01

    Full Text Available Background/purpose: We assessed the mobility of single-root teeth by using Miller's mobility index (MMI and to analyze the validity of MMI for the diagnosis of periodontitis. Materials and methods: A total of 30 patients were included and the Spearman correlation coefficient was used to assess the correlation between MMI, clinical attachment level (CAL, and probing depth (PD. The validity of MMI for the diagnosis of the severity of periodontitis was evaluated using the receiver operating characteristic (ROC curve, area under curve (AUC value, positive predictive value (PPV. Results: Strong correlations were observed between MMI and CAL (r = 0.92 and between MMI and PD (r = 0.76. When the CAL = 3–4 mm and CAL ≥5 mm groups were pooled together, the AUC value was 0.81. The AUC was 0.86 for diagnosis with MMI in the CAL ≥5 mm group. A PPV of 100% was achieved for all grades when MMI >1. When the teeth with PD ≥ 5 to <7 mm and PD ≥ 7 mm groups were pooled together, the AUC value for MMI was 0.80. The PPV was 98.8%, 99%, and 100% for MMI Grade 1, Grade 2, and Grade 3, respectively. When PD ≥ 7 mm was defined as severe periodontitis, the AUC value for MMI was 0.72. Conclusion: MMI may provide valuable information for the diagnosis of moderate and severe periodontitis when CAL is not obtainable during routine practice. Keywords: Miller's mobility index, Negative predictive value, Nonsurgical periodontal therapy, Positive predictive value, Receiver operating characteristic curve, Tooth mobility

  13. 1 küsimus noorele juhile : Mis teha, kui kopp on ees - kuidas sa stressist jagu saad? / Riho Jürvetson, Merit Miller, Krister Rekkaro ... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad EMT erakliendi osakonna juhataja Riho Jürvetson, KPMG Baltics müügijuht Merit Miller, ArtPrint juht Krister Rekkaro, Dateli juhatuse liige Triin Sepp, Media House projektijuht Tanel Tarkmees, Ober-Haus Kinnisvara tegevjuht Katrin Klein-Näppi

  14. Growth inhibition of Dalmatian toadflax, Linaria dalmatica (L.) Miller, in response to herbivory by the biological control agent Mecinus janthinus Germar

    Science.gov (United States)

    Marjolein Schat; Sharlene E. Sing; Robert K. D. Peterson; Fabian D. Menalled; David K. Weaver

    2011-01-01

    Our study reports the results of field and garden experiments designed to quantitatively evaluate the impact of herbivory by a weed biological control agent, the stem-mining weevil Mecinus janthinus Germar, on the growth of its exotic host Dalmatian toadflax, Linaria dalmatica (L.) Miller. Herbivory by M. janthinus under both natural and manipulated environmental...

  15. Evaluation of the C-MAC Miller Video Laryngoscope Sizes 0 and 1 During Tracheal Intubation of Infants Less Than 10 kg.

    Science.gov (United States)

    Raimann, Florian J; Cuca, Colleen E; Kern, Detlev; Zacharowski, Kai; Rolle, Udo; Meininger, Dirk; Weber, Christian F; Byhahn, Christian; Mutlak, Haitham

    2017-10-02

    Video laryngoscopy has primarily been developed to assist in difficult airways. Using video laryngoscopy in pediatric airway management is an up-and-coming topic. The aim of the presented study was to compare the intubation conditions obtained when using the C-MAC video laryngoscope with Miller blades sizes 0 and 1 for standard direct laryngoscopy and indirect laryngoscopy in children weighing less than 10 kg. This was a prospective study. The study was performed in a university hospital. Following ethical approval, 86 infants weighing less than 10 kg and undergoing surgery under general anesthesia were studied prospectively. Indirect and direct laryngoscopy either with C-MAC Miller blade size 0 or size 1. First, direct laryngoscopy was performed, and the best obtained view was graded without looking at the video monitor. A second investigator blinded to the view obtained under direct laryngoscopy graded the laryngeal view on the video monitor. Time to intubation, intubation conditions, and intubation attempts were recorded. In infants less than 10 kg, intubation conditions were excellent. There were no significant differences between the use of Miller blade 0 or 1 in reference to Cormack-Lehane grade, time to intubation, time to best view, or intubation attempts. Comparing direct and indirect intubation conditions using either Miller blade 0 or 1 revealed that the use of indirect laryngoscopy provided a significantly better view (P < 0.05) of the vocal cords. In 3 infants weighing more than 8 kg, the Miller blade 0 was described as too short and narrow for intubation. Both devices allowed for an excellent visualization of the vocal cords.

  16. Crescimento inicial e composição química de Pereskia aculeata Miller cultivada em diferentes luminosidades

    Directory of Open Access Journals (Sweden)

    Carla Regina Amorim dos Anjos Queiroz

    2015-07-01

    Full Text Available A Pereskia aculeata Miller é uma hortaliça não convencional cujo consumo pode fornecer à dieta substâncias nutritivas e antioxidantes, ambas com teores influenciados pelas condições de cultivo. Foram cultivadas, a partir de sementes, plantas em sombra artificial, em meia sombra e sem sombra. Avaliou-se o crescimento em termos de massa e unidades estruturais e quantificou-se o resíduo mineral, proteínas, lipídeos, fibra em detergente neutro, fenóis e atividade antioxidante. Há influência do sombreamento no crescimento, no teor de nutrientes e metabólitos secundários. As plantas sem sombra apresentaram maior altura, número de folhas, diâmetro do colo, massa seca de caules e folhas e atividade antioxidante. As plantas totalmente sombreadas apresentaram maiores teores de cinzas, lipídeos e proteínas. Para todos os parâmetros avaliados os teores quantificados em folhas foram maiores que em caules.

  17. Traceability of Opuntia ficus-indica L. Miller by ICP-MS multi-element profile and chemometric approach.

    Science.gov (United States)

    Mottese, Antonio Francesco; Naccari, Clara; Vadalà, Rossella; Bua, Giuseppe Daniel; Bartolomeo, Giovanni; Rando, Rossana; Cicero, Nicola; Dugo, Giacomo

    2018-01-01

    Opuntia ficus-indica L. Miller fruits, particularly 'Ficodindia dell'Etna' of Biancavilla (POD), 'Fico d'india tradizionale di Roccapalumba' with protected brand and samples from an experimental field in Pezzolo (Sicily) were analyzed by inductively coupled plasma mass spectrometry in order to determine the multi-element profile. A multivariate chemometric approach, specifically principal component analysis (PCA), was applied to individuate how mineral elements may represent a marker of geographic origin, which would be useful for traceability. PCA has allowed us to verify that the geographical origin of prickly pear fruits is significantly influenced by trace element content, and the results found in Biancavilla PDO samples were linked to the geological composition of this volcanic areas. It was observed that two principal components accounted for 72.03% of the total variance in the data and, in more detail, PC1 explains 45.51% and PC2 26.52%, respectively. This study demonstrated that PCA is an integrated tool for the traceability of food products and, at the same time, a useful method of authentication of typical local fruits such as prickly pear. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  18. Cálculo de la resistencia a la penetración en hojas de aloe vera (Barbadenses Miller

    Directory of Open Access Journals (Sweden)

    Giovanni Torres Charry

    2013-12-01

    Full Text Available Para caracterizar la resistencia a la penetración de hojas de aloe vera, variedad Barbadenses Miller, se diseñó una máquina y se establecieron los protocolos de medición para desplazamiento y fuerza necesarios para medir la resistencia a la penetración en tres puntos diferentes de las hojas. Los resultados mostraron que no existe una relación lineal entre el desplazamiento del indentador en la hoja y la fuerza de penetración. Por otro lado, se encontró que no existen diferencias en los valores de la fuerza de penetración al evaluar ésta en distintos puntos para una misma hoja. Se hallaron diferencias en los valores obtenidos entre hojas diferentes, lo que permite suponer que existe influencia de las características dimensionales de las hojas en el valor de la fuerza de penetración. Los valores máximos obtenidos para la fuerza de penetración variaron entre 22 y 27 N, para una velocidad de avance de la herramienta de 2.6 mm/s.

  19. Symptomatic Recovery in Miller Fisher Syndrome Parallels Vestibular-Perceptual and not Vestibular-Ocular Reflex Function.

    Science.gov (United States)

    Seemungal, Barry M; Masaoutis, Panos; Green, David A; Plant, Gordon T; Bronstein, Adolfo M

    2011-01-01

    Unpleasant visual symptoms including oscillopsia and dizziness may occur when there is unexpected motion of the visual world across the subject's retina ("retinal slip") as in an acute spontaneous nystagmus or on head movement with an acute ophthalmoplegia. In contrast, subjects with chronic ocular dysmotility, e.g., congenital nystagmus or chronic progressive external ophthalmoplegia, are typically symptom free. The adaptive processes that render chronic patients asymptomatic are obscure but may include a suppression of oscillopsia perception as well as an increased tolerance to perceived oscillopsia. Such chronic asymptomatic patients display an attenuation of vestibular-mediated angular velocity perception, implying a possible contributory role in the adaptive process. In order to assess causality between symptoms, signs (i.e., eye movements), and vestibular-perceptual function, we prospectively assessed symptom ratings and ocular-motor and perceptual vestibular function, in a patient with acute but transient ophthalmoplegia due to Miller Fisher Syndrome (as a model of visuo-vestibular adaptation). The data show that perceptual measures of vestibular function display a significant attenuation as compared to ocular-motor measures during the acute, symptomatic period. Perhaps significantly, both symptomatic recovery and normalization of vestibular-perceptual function were delayed and then occurred in a parallel fashion. This is the first report showing that symptomatic recovery of visuo-vestibular symptoms is better paralleled by vestibular-perceptual testing than vestibular-ocular reflex (VOR) measures. The findings may have implications for the understanding of patients with chronic vestibular symptoms where VOR testing is often unhelpful.

  20. An Overlapping Case of Miller Fisher Syndrome, Bickerstaff’s Encephalitis, and the ASMAN Variant of Guillain-Barre Syndrome

    Directory of Open Access Journals (Sweden)

    E. J. Pegg

    2016-01-01

    Full Text Available A 56-year-old man presented with a 3-day history of progressive tingling of the hands, unsteadiness, and diplopia. He was initially diagnosed clinically with Miller Fisher Syndrome (MFS but later developed limb weakness consistent with Guillain-Barre Syndrome (GBS and subsequently reduced consciousness consistent with Bickerstaff’s brainstem encephalitis (BBE. Neurophysiology revealed an axonal motor and sensory neuropathy, in keeping with the Acute Motor and Sensory Axonal Neuropathy (AMSAN variant of GBS. We believe that our patient had an MFS-AMSAN-BBE overlap syndrome. This is supported by his glycolipid antibody profile with high titres of anti-GQ1b IgG antibody and anti-GD1a IgG antibody. Anti-GQ1b antibodies are frequently found in both MFS and BBE and the anti-GD1a antibody is associated with axonal forms of GBS. Overlapping cases of MFS and BBE are well described, and because the same antibody is often found in both conditions, it is thought that they share a common autoimmune mechanism. BBE has also been previously reported in association with GBS lending support that it also lies on the same spectrum. This overlapping case of ASMAN variant of GBS, MFS, and BBE provides further support that these conditions are part of the same spectrum.

  1. Taxonomic review of the genus Chamaemelum Miller (Asteraceae) in the Iberian peninsula and the Balearic lslands

    OpenAIRE

    Benedí i González, Carles

    1988-01-01

    A taxonomic review of the genus Chamaemelum Miller (Asteraceae) in the Iberian peninsula and the Balearic Islands is carried out. Two changes in nomenclature are proposed: Chamaemelum nobile ( L.) All. forma discoideum (Willk.) comb. & stat. nov. and C. fuscatum (Brot.) Vasc. forma minor (Hoffmanns. & Link) comb. & stat. nov. For each taxon the correct name as well as ...

  2. Use of Grass and Spent Mushroom Compost as a Growing Medium of Local Tomato (Lycopersicon Esculentum Miller) Seedling in the Nursery

    OpenAIRE

    Priadi, Dody; Arfani, Agus; Saskiawan, Iwan; Mulyaningsih, Enung Sri

    2016-01-01

    The objective of this study was to investigate the response of local tomato (Lycopersicon esculentum Miller) seedlings growth on media containing grass and spent mushroom compost in the nursery. The grass compost (GC) was produced by Research Center for Biotechnology-LIPI. Whereas the spent oyster mushroom (Pleurotus ostreatus) compost (OC) and spent paddy straw mushroom (Volvariella volvacea) compost (PC) were produced by Research Center for Biology-LIPI. Growing media of tomato seedling was...

  3. "What's happened to this family anyway?" : the disintegration of the American family in selected plays by O'Neill, Miller, and Shepard

    OpenAIRE

    Mathisen, Kari

    2009-01-01

    This thesis examines the disintegration of the American family as depicted in selected plays by Eugene O’Neill, Arthur Miller, and Sam Shepard. Four plays are central: Long Day’s Journey into Night (1956), Death of a Salesman (1949), Buried Child (1978), and True West (1980). (Journey and Salesman constitute my major focus and serve to generate my thesis statement, while Buried Child and True West illuminate the thematic concerns of Journey and Salesman from quite a different perspective, and...

  4. Miller, Karina. Escrituras Impolíticas. Anti-representaciones de la comunidad en Juan Rodolfo Wilcock, Osvaldo Lamborghini y Virgilio Piñera. Pittsburgh: Instituto Internacional de Literatura Iberoamericana Universidad de Pittsburgh, 2013. Print. 155 pp.

    OpenAIRE

    Del Toro, José César

    2017-01-01

    Miller, Karina. Escrituras Impolíticas. Anti-representaciones de la comunidad en Juan  Rodolfo Wilcock, Osvaldo Lamborghini y Virgilio Piñera. Pittsburgh: Instituto Internacional de Literatura Iberoamericana Universidad de Pittsburgh, 2013. Print. 155 pp.

  5. Plankton and other data collected from net casts in the Gulf of Alaska and Bering Sea from NOAA Ship MILLER FREEMAN from 1976-04-26 to 1976-05-31 (NCEI Accession 7700419)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Plankton and other data were collected using net casts in the Gulf of Alaska and Bering Sea from NOAA Ship MILLER FREEMAN from 26 April 1976 to 31 May 1976. Data...

  6. Underway physical and meteorological data collected by NOAA Ship MILLER FREEMAN in the North Pacific, Gulf of Alaska and Bering Sea from 2001-01-24 to 2001-07-09 (NODC Accession 0000547)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical, meteorological, and other data were collected in the Gulf of Alaska and the NE Pacific (limit-180) from NOAA Ship MILLER FREEMAN from 24 January 2001 to 09...

  7. Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946-2008

    International Nuclear Information System (INIS)

    Kreuzer, M.; Dufey, F.; Schnelzer, M.; Sogl, M.; Walsh, L.; Nowak, D.

    2015-01-01

    To examine exposure-response relationships between ionizing radiation and several mortality outcomes in a subgroup of 4,054 men of the German uranium miner cohort study, who worked between 1946 and 1989 in milling facilities, but never underground or in open pit mines. Mortality follow-up was from 1946 to 2008, accumulating 158,383 person-years at risk. Cumulative exposure to radon progeny in working level months (WLM) (mean = 8, max = 127), long-lived radionuclides from uranium ore dust in kBqh/m 3 (mean = 3.9, max = 132), external gamma radiation in mSv (mean = 26, max = 667) and silica dust was estimated by a comprehensive job-exposure matrix. Internal Poisson regression models were applied to estimate the linear excess relative risk (ERR) per unit of cumulative exposure. Overall, a total of 457, 717 and 111 deaths occurred from malignant cancer, cardiovascular diseases and non-malignant respiratory diseases, respectively. Uranium ore dust and silica dust were not associated with mortality from any of these disease groups. A statistically significant relationship between cumulative radon exposure and mortality from all cancers (ERR/100 WLM = 1.71; p = 0.02), primarily due to lung cancer (n = 159; ERR/100 WLM = 3.39; p = 0.05), was found. With respect to cumulative external gamma radiation, an excess of mortality of solid cancers (n = 434; ERR/Sv = 1.86; p = 0.06), primarily due to stomach cancer (n = 49, ERR/Sv = 10.0; p = 0.12), was present. The present findings show an excess mortality from lung cancer due to radon exposure and from solid cancers due to external gamma radiation in uranium millers that was not statistically significant. Exposure to uranium was not associated with any cause of death, but absorbed organ doses were estimated to be low.

  8. Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946-2008

    Energy Technology Data Exchange (ETDEWEB)

    Kreuzer, M.; Dufey, F.; Schnelzer, M.; Sogl, M.; Walsh, L. [Federal Office for Radiation Protection, Neuherberg (Germany). Dept. of Radiation Protection and Health; Laurier, D. [Institute for Radiological Protection and Nuclear Safety (IRSN), Paris (France); Nowak, D. [LMU Muenchen (Germany). Inst. for Occupational Medicine and Environmental Medicine; Marsh, J.W. [Public Health England, Chilton, Didcot (United Kingdom)

    2015-05-15

    To examine exposure-response relationships between ionizing radiation and several mortality outcomes in a subgroup of 4,054 men of the German uranium miner cohort study, who worked between 1946 and 1989 in milling facilities, but never underground or in open pit mines. Mortality follow-up was from 1946 to 2008, accumulating 158,383 person-years at risk. Cumulative exposure to radon progeny in working level months (WLM) (mean = 8, max = 127), long-lived radionuclides from uranium ore dust in kBqh/m{sup 3} (mean = 3.9, max = 132), external gamma radiation in mSv (mean = 26, max = 667) and silica dust was estimated by a comprehensive job-exposure matrix. Internal Poisson regression models were applied to estimate the linear excess relative risk (ERR) per unit of cumulative exposure. Overall, a total of 457, 717 and 111 deaths occurred from malignant cancer, cardiovascular diseases and non-malignant respiratory diseases, respectively. Uranium ore dust and silica dust were not associated with mortality from any of these disease groups. A statistically significant relationship between cumulative radon exposure and mortality from all cancers (ERR/100 WLM = 1.71; p = 0.02), primarily due to lung cancer (n = 159; ERR/100 WLM = 3.39; p = 0.05), was found. With respect to cumulative external gamma radiation, an excess of mortality of solid cancers (n = 434; ERR/Sv = 1.86; p = 0.06), primarily due to stomach cancer (n = 49, ERR/Sv = 10.0; p = 0.12), was present. The present findings show an excess mortality from lung cancer due to radon exposure and from solid cancers due to external gamma radiation in uranium millers that was not statistically significant. Exposure to uranium was not associated with any cause of death, but absorbed organ doses were estimated to be low.

  9. Protective effect of two extracts of Cydonia oblonga miller (Quince fruits on gastric ulcer induced by indomethacin in rats

    Directory of Open Access Journals (Sweden)

    Morteza Parvan

    2017-01-01

    Full Text Available Background: In various studies, Cydonia oblonga Miller (quince has been reported to have many properties such as antioxidant and anti-ulcerative effects. This study has aimed to investigate the protective effects of quince aqueous extract (QAE and quince hydroalcoholic extract (QHE on gastric ulcer caused by indomethacin and the relevant macroscopic, histopathology, and biochemical factors in rats. Methods: Ten groups of male Wistar rats, six in each, were used in this study. These groups included: normal (distilled water, control (distilled water + indomethacin, reference (ranitidine or sucralfate + indomethacin, and test groups (QAE or QHE + indomethacin treated with three increasing doses (200, 500, and 800 mg/kg. Extracts and drugs were given orally to rats 1 h before injecting the indomethacin (25 mg/kg, intraperitoneally. Six hours later, the abdomen of rats was exposed, its pylorus was legated, gastric acid content was extracted, and its pH and the amount of pepsin secreted were measured by Anson method. Then, histopathology indices, ulcer area, ulcer index, and myeloperoxidase (MPO activity were measured in gastric mucus. Results: Both extracts of quince were effective to reduce the acidity of stomach and pepsin activity. Compared to control group, the average of enzyme activity of MPO was significantly declined in all treated groups. Control group had the highest level of gastric ulcer indices including severity, area, and index while the evaluated parameters had decreased in all extract treated groups although it seems that QAE was somewhat more effective. Conclusions: Protective effect of QAE and QHE on gastric ulcer was done by undermining offensive factors including decreasing the secretion of gastric acid and pepsin activity and by strengthening the protective factors of gastric mucus including antioxidant capacity.

  10. Level II scour analysis for Bridge 36 (STOWTH00430036) on Town Highway 43, crossing Miller Brook, Stowe, Vermont

    Science.gov (United States)

    Striker, Lora K.; Wild, Emily C.

    1997-01-01

    This report provides the results of a detailed Level II analysis of scour potential at structure STOWTH00430036 on Town Highway 43 crossing the Miller Brook, Stowe, Vermont (figures 1–8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (U.S. Department of Transportation, 1993). Results of a Level I scour investigation also are included in Appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, gleaned from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in Appendix D. The site is in the Green Mountain section of the New England physiographic province in north central Vermont. The 5.5-mi2 drainage area is in a predominantly rural and forested basin. In the vicinity of the study site, the surface cover is predominantly forested. In the study area, the Miller Brook has an incised, sinuous channel with a slope of approximately 0.03 ft/ft, an average channel top width of 43 ft and an average bank height of 7 ft. The channel bed material ranges from gravel to boulder with a median grain size (D50) of 70.4 mm (0.231 ft). The geomorphic assessment at the time of the Level I and Level II site visit on July 15, 1996, indicated that the reach was stable. The Town Highway 43 crossing of the Miller Brook is a 24-ft-long, two-lane bridge consisting of one 21-foot steel-beam span (Vermont Agency of Transportation, written communication, October 13, 1995). The opening length of the structure parallel to the bridge face is 21.5 ft. The bridge is supported by vertical, concrete abutments with wingwalls. The channel is skewed approximately 10 degrees to the opening and the computed opening-skew-to-roadway is also 10 degrees. The footing on the left abutment was exposed 2.5 ft and the footing on the right abutment was exposed 3.0 ft during

  11. Kodukoharaamatud / Voldemar Miller

    Index Scriptorium Estoniae

    Miller, Voldemar, 1911-2006

    1996-01-01

    Virve Orav. Narva-Jõesuu kodu-uurija pilguga. 1993. Helmut Elstrok. Padaorust Viru mereni. Viru-Nigula - Tln., 1994. Helmut Elstrok. Kõrvemaast Põhjarannani. Kuusalu - Tln.-Tapa, 1995. Lembit Arulo. Nii see olla võis... Põhjaranniku külaelust läbi aegade. Tln., 1994. Robert Nerman. Kopli. Miljöö, olustik, kultuurilugu 1918-1940. Tln., 1995. Ain Sarv. Varjusurmast tõusnud. Eestirootslaste ja Eestirootsi alade saatusest pärast Teist maailmasõda, Tln., 1994. Jaan Ellen. Kuhu kõik nad jäid? Tõsilugu Urvaste ürgorust. Tln., 1994

  12. Miller Fisher Syndrome

    Science.gov (United States)

    ... us help others will be most gratefully appreciated. Non-profit 501(c)(3). Honorary Board Rachel Chagall* Marjorie H. Downey* Andy Griffith* Joseph Heller* # Executive Director Estelle L. Benson Officers Sara Voorhees Pessel,* President ...

  13. Marked improvement of thyroid function and autoimmunity by Aloe barbadensis miller juice in patients with subclinical hypothyroidism

    Directory of Open Access Journals (Sweden)

    Daniela Metro

    2018-03-01

    Full Text Available Some natural compounds decrease serum levels of thyroid autoantibodies, but results are inconsistent and thyroid function has been evaluated infrequently; moreover, the effects of Aloe on thyroid autoimmunity and function have been examined in very few studies. This study stems from the observation of one co-author, who has Hashimoto’s thyroiditis (HT-related subclinical hypothyroidism (SCH. Upon checking her biochemical thyroid panel when taking daily Aloe barbardensis Miller juice (ABMJ for thyroid-unrelated reasons, she noticed a decrease in serum thyroperoxidase autoantibodies (TPOAb and thyrotropin (TSH and an increase in serum free thyroxine (FT4. Based on this observation, we enrolled 30 consecutive HT women with levothyroxine-untreated SCH and high TPOAb levels. All of them took ABMJ (50 ml daily for nine months and were tested for serum TSH, FT4, free triiodothyronine (FT3 and TPOAb. Measurements were performed at baseline and at months 3 and 9. TSH, FT4 and TPOAb improved significantly already at month 3 and further (−61%, +23% and −56% at month 9. However, FT3 decreased significantly at month 3 (−16% with no further decrease at month 9, so that the FT4:FT3 ratio increased significantly (+33% and + 49%. At baseline, 100% of women had TSH > 4.0 mU/L and TPOAb > 400 U/ml, but frequencies fell to 0% and 37%, respectively, at month 9. In contrast, a control group (namely, 15 untreated SCH women of comparable age and baseline levels of TSH, FT4, FT3 and TPOAb had no significant changes in any index. We conclude that the daily intake of 100 ml ABMJ for 9 months in women with HT-related SCH decreases the burden of thyroid autoimmune inflammation. In addition, ABMJ rescues thyrocyte function, with decreased need for conversion of the prohormone T4 into the more active T3 through ABMJ-induced inhibition of T4 deiodination. Keywords: Aloe vera, Subclinical hypothyroidism, Thyroid autoimmunity, Thyroid function

  14. Gestión integrada de plagas de los artrópodos implicados en el secado de la copa en Pinus halepensis Miller

    OpenAIRE

    PEREA CAROT, DANIEL

    2016-01-01

    [ES] En el último año se han apreciado daños en las copas de Pinus halepensis Miller consistentes en el secado de las acículas de la copa, sobretodo de la parte superior y más externa. Estos daños parecen haber aumentado tras este último cálido invierno. El nivel de afectación de los pinos no es homogéneo en todos los individuos, pudiendo haber individuos totalmente sanos y otros con prácticamente la totalidad de la copa afectada, todo ello en la misma zona de muestreo. Por otra parte, en est...

  15. A survey for potential biological control agents of Pereskia aculeata Miller (Cactaceae) in Brazil reveals two new species of Horismenus Walker (Hymenoptera: Eulophidae).

    Science.gov (United States)

    Pikart, Tiago G; Costa, Valmir A; Hansson, Christer; Cristo, Sandra C DE; Vitorino, Marcelo D

    2017-05-30

    This paper deals with the description of two new species of Horismenus Walker (Hymenoptera: Eulophidae) from Brazil, parasitoids of larvae of Adetus analis (Haldeman) (Coleoptera: Cerambycidae). Both species are similar to Horismenus steirastomae (Girault), a species that also parasitizes cerambycids. Adetus analis is a pest of Sechium edule (Jacq.) Swartz (Cucurbitaceae), a minor crop in Brazil, Argentina and U.S.A., but also feeds in stems of Pereskia aculeata Miller (Cactaceae), an ornamental plant that has become a problematic weed species in Africa, where it was introduced. The two new Horismenus species are described, diagnosed, and compared to H. steirastomae.

  16. Taxonomic review of the genus Chamaemelum Miller (Asteraceae in the Iberian peninsula and the Balearic lslands

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    Benedí i González, Carles

    1988-01-01

    Full Text Available A taxonomic review of the genus Chamaemelum Miller (Asteraceae in the Iberian peninsula and the Balearic Islands is carried out. Two changes in nomenclature are proposed: Chamaemelum nobile ( L. All. forma discoideum (Willk. comb. & stat. nov. and C. fuscatum (Brot. Vasc. forma minor (Hoffmanns. & Link comb. & stat. nov. For each taxon the correct name as well as the corresponding synonyms are given. A dichotomic key of the recognized taxa and a list of the herharium sheets studied are provided.

    Se realiza una revisión taxonómica del género Chamaemelum Miller (Asteraceae en la Península Ibérica e Islas Baleares. Se proponen dos cambios nomenclaturles: Chamaemelum nobile (L. All. forma discoideum (Willk. comb. & stat. nov. y C. fuscatum (Brot. Vasc. forma minor (Hoffmanns. & Link comb. & stat. nov. Para cada taxon se da el nombre correcto, así como las correspondientes sinonimias. Se adjunta una clave dicotómica de los táxones reconocidos y una relación de los testimonios de herbario estudiados.

  17. Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth. Part II: Gas, Oil, Water and the Oil/Water-Interface

    Science.gov (United States)

    Scherer, Sabrina; Wollrab, Eva; Codutti, Luca; Carlomagno, Teresa; da Costa, Stefan Gomes; Volkmer, Andreas; Bronja, Amela; Schmitz, Oliver J.; Ott, Albrecht

    2017-12-01

    We have analyzed the chemical variety obtained by Miller-Urey-type experiments using nuclear magnetic resonance (NMR) spectroscopy and coherent anti-Stokes Raman scattering (CARS) spectroscopy, gas chromatography followed by mass spectrometry (GC/MS) and two-dimensional gas chromatography followed by mass spectrometry (GCxGC/MS). In the course of a running Miller-Urey-type experiment, a hydrophobic organic layer emerged besides the hydrophilic aqueous phase and the gaseous phase that were initially present. The gas phase mainly consisted of aromatic compounds and molecules containing C≡ C or C≡ N triple bonds. The hydrophilic phase contained at least a few thousands of different molecules, primarily distributed in a range of 50 and 500 Da. The hydrophobic phase is characterized by carbon-rich, oil-like compounds and their amphiphilic derivatives containing oxygen with tensioactive properties. The presence of a wide range of oxidized molecules hints to the availability of oxygen radicals. We suggest that they intervene in the formation of alkylated polyethylene glycol (PEG) in the oil/water interface. CARS spectroscopy revealed distinct vibrational molecular signatures. In particular, characteristic spectral bands for cyanide compounds were observed if the broth was prepared with electric discharges in the gaseous phase. The characteristic spectral bands were absent if discharges were released onto the water surface. NMR spectroscopy on the same set of samples independently confirmed the observation. In addition, NMR spectroscopy revealed overall high chemical variability that suggests strong non-linearities due to interdependent, sequential reaction steps.

  18. “A source of satisfaction to all Jews, wherever they may be living”. Louis Miller between New York and Tel Aviv, 1911

    Directory of Open Access Journals (Sweden)

    Ehud Manor

    2011-10-01

    Full Text Available Although throughout the middle-ages Jews used to live in urban environment more than non-Jews, urbanization process in the 19th century was as critical to Jewish modern history as in other cases. Modernization, in all aspects, had a deep impact on Jewish demography, socio-economic life and self understanding. On the same time Jews were immigrating by the millions to the “new world” (mainly to the United States, a small current of Jews was heading to Palestine (Eretz Israel if to use their specific term. As opposed to a common understanding of Zionism, the future city and the neo-urbanization of the Jews – and not only the new villages (Moshavot, Kibbutzim, Moshavim – was a main Zionist goal. This article describes one of the first comprehensive observations of these issues, as seen from the eyes of Louis Miller, himself a Jewish immigrant that settled in the outmost city of the modern world: New York. In 1911 he paid a visit to the one-year-old Tel Aviv, and managed to see in this new modest garden-city the cradle of the Zionist revolution. Not less important: Miller understood as early as 1911, the crucial role Jewish settlements in Palestine would have in the crystallization of modern Jewish peoplehood. Tel Aviv took major part in this development. It still does.

  19. The Effect of Salinity Stress on the Growth, quantity and quality of Essential oil of Lavender (Lavandula angustifulia Miller

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    sarah khorasaninejad

    2017-02-01

    Full Text Available Introduction: Plants are usually exposed to different environmental stresses which limit their growth and productivity as well as cause considerable loss of worldwide agricultural production. One of the most important factors affecting plant and production of secondary metabolites is the salt stress. Salinity of soil or water is one of major stress, obstacles to increase production in plant growing areas throughout the world and especially in arid and semi-arid regions it can severely limit plant production. Iran is among the world's arid and semi-arid land, and faces water resources shortage and saline lands. According to the concept of sustainable development and role of Agriculture, using saline water and soil resources seems mandatory. Recently, medicinal and aromatic plants have received much attention in several fields such as agroalimentary, perfumes, pharmaceutical industries and natural cosmetic products. Although, secondary metabolites in the medicinal and aromatic plants were fundamentally produced by genetic processing, but, their biosynthesis are strongly influenced by environmental factors. It means that biotic and abiotic environmental factors affect growth parameter, essential oil yield and constituents. Abiotic environmental stresses, especially salinity and drought have the most effect on medicinal plant. Medicinal plants cultivation is one of ways to exploit these resources. Essential oils help to easier adapt to the environmental stress conditions. Also, essential oils are not constantly in the quantitative and qualitative terms. They are changing continuously, due to the requirements of the environment, and to individual survival. The different results were dedicated from the effect of salinity stress on the quantitative and qualitative parameters. Lavender (Lavandula angustifulia Miller is a perennial woody medicinal plant that cultivated for its an essential oil in leafs and flowers. Major parts of Lavender produces

  20. TOURISM AS REFLECTED IN TRAVELLING WOMEN: A COMPARATIVE CULTURAL STUDY ON THE NOVELS OF DAISY MILLER, A PASSAGE TO INDIA, AND PADA SEBUAH KAPAL

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    Sri Hartiningsih

    2012-11-01

    Full Text Available Travelling has occurred since a long time ago. Travelling is not only done by men butalso by women. In relation to travelling, travelling done by women is examined, especially thelandlady’s environment, as there is a relationship between the host and the guest. The researchproblems are (1 how is reflection of tourism in the travelling women portrayed on the novels ofDaisy Miller, A Passage to India, and Pada Sebuah Kapal?. (2 How are motivating andattracting factors related to tourism as reflected in the travelling women articulated on the novelsof Daisy Miller, A Passage to India, and Pada Sebuah Kapal?. (3 How do cultural barriersoccur in tourism as reflected in the travelling women on Daisy Miller, a Passage to India, andPada Sebuah Kapal novel? In general, this research is to find out the comparison of travellingdone by women. Specifically, it is to discover the reflection of tourism, how the motivating andattracting factors and cultural barriers occur in tourism as reflected in the travelling done bywomen.This research is conducted on three novels, Daisy Miller written by Henry James, APassage To India by E.M. Forster, and Pada Sebuah Kapal by NH. Dini called comparativeliterature showing the continents of America, Europe and Asia. Discussing the three continents,this research is called global literature. Hermeneutic method was used to interpret the content ofthose three novels by employing deconstruction, postcolonial and feminism theories. The maindata were taken from those novels and the location of the research was both at private librariesand state libraries or institutions and websites. To support the main data, secondary data werealso needed, which in this case, were obtained by interviewing the women who have travelledabroad. Then the results were formally and informally presented.The findings show that the reflection of tourism in travelling done by women is representedby family companion, and that the means of transportation to

  1. Ilza Veith (1912-2013 e Genevieve Miller (1914-2013: longas vidas dedicadas à história da medicina

    Directory of Open Access Journals (Sweden)

    Everardo Duarte Nunes

    2015-07-01

    Full Text Available Resumo O artigo analisa aspectos biobibliográficos de duas historiadoras da medicina: Ilza Veith (1912-2013 e Genevieve Miller (1914-2013. Ambas fizeram a sua formação no Institute of History of Medicine da Johns Hopkins University e tiveram como mentor intelectual o historiador Henry Ernest Sigerist (1891-1957. Autoras de obras originais, Ilza no campo da medicina oriental e Genevieve no campo da história da ciência, ao longo da carreira tiveram importante participação na pesquisa, docência e divulgação da história da medicina, marcada pelo pioneirismo de suas atividades.

  2. Power, efficiency, ecological function and ecological coefficient of performance of an irreversible Dual-Miller cycle (DMC) with nonlinear variable specific heat ratio of working fluid

    Science.gov (United States)

    Wu, Zhixiang; Chen, Lingen; Ge, Yanlin; Sun, Fengrui

    2017-05-01

    Finite time thermodynamic (FTT) theory is applied to perform performance analysis for an air-standard irreversible Dual-Miller cycle (DMC) based on the power output (P), thermal efficiency (η, ecological function (E) and ecological coefficient of performance (ECOP) criteria by considering nonlinear variable specific heat ratio, piston friction loss, heat transfer loss and other internal irreversible losses. Relationships between different performance characteristics are obtained via numerical calculations. Effects of pressure ratio and stroke length on each criterion are analyzed, and performance characteristics with different optimization objective are compared. The results show that pressure ratio has little influence on performance characteristics, but stroke length has great influence on performance characteristics. Moreover P, η, E and ECOP decrease with increasing stroke length, but when stroke length increases to a certain value, E is less than 0 whatever value of compression ratio takes. Choosing the E and ECOP as optimization objectives is more significant by comparing with other performance indexes.

  3. Acetylcholine suppresses shoot formation and callusing in leaf explants of in vitro raised seedlings of tomato, Lycopersicon esculentum Miller var. Pusa Ruby.

    Science.gov (United States)

    Bamel, Kiran; Gupta, Rajendra; Gupta, Shirish C

    2016-06-02

    We present experimental evidence to show that acetylcholine (ACh) causes decrease in shoot formation in leaf explants of tomato (Lycopersicon esculentum Miller var Pusa Ruby) when cultured on shoot regeneration medium. The optimum response was obtained at 10(-4) M ACh-enriched medium. ACh also causes decrease in percentage of cultures forming callus and reduces the callus mass. Inhibitors of enzymatic hydrolysis of ACh, neostigmine and physostigmine, also suppresses callogenesis and caulogenesis. On the other hand, the breakdown products of Ach, choline and acetate, do not alter the morphogenic response induced on the shoot regeneration medium. Neostigmine showed optimal reduction in shoot formation at 10(-5) M. The explants cultured on neostigmine augmented medium showed decline in the activity of ACh hydrolyzing enzyme acetylcholinesterase. ACh and neostigmine added together showed marked reduction in callus mass. These results strongly support the role of ACh as a natural regulator of morphogenesis in tomato plants.

  4. Enantioselective comprehensive two-dimensional gas chromatography. A route to elucidate the authenticity and origin of Rosa damascena Miller essential oils.

    Science.gov (United States)

    Krupčík, Ján; Gorovenko, Roman; Špánik, Ivan; Sandra, Pat; Armstrong, Daniel W

    2015-10-01

    The analysis of Bulgarian and Turkish Rosa damascena Miller essential oils was performed by flow-modulated comprehensive two-dimensional gas chromatography using simultaneous detection of the second column effluent by flame ionization and quadrupole mass spectrometric detection. Enantioselective separations were obtained by running the samples on 2,3-di-O-ethyl-6-O-tert-butyldimethylsilyl-β-cyclodextrin column as the first column and on polyethylene glycol as the second column. The determination of enantiomeric or diastereomeric excess of some terpenoic solutes is a possible route for quality or authenticity control as well as for the elucidation of the country of origin. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Enhanced Miller plateau characteristics of a 4H-SiC insulated-gate bipolar transistor in the presence of interface traps

    Science.gov (United States)

    Navarro, Dondee; Tone, Akihiro; Kikuchihara, Hideyuki; Morikawa, Yoji; Miura-Mattausch, Mitiko

    2017-04-01

    Miller plateau characteristics of a 4H-SiC insulated-gate bipolar transistor (IGBT) is investigated during a gate voltage turn-on under the presence of interface carrier traps at the MOSFET gate oxide. The plateau, which is observed in the device gate-emitter voltage, increased with respect to both height and length. The plateau height is mainly determined by the density increase of trap states, which also causes slow charging of the gate capacitance in the overlap region that results in a longer plateau length. The shallow trap states contribute mainly to the plateau increase. It is observed that the switching loss at turn-on can increase by more than 60% due mainly to the carrier traps at the shallow trap states.

  6. A Case of Concurrent Miller-Dieker Syndrome (17p13.3 Deletion) and 22q11.2 Deletion Syndrome.

    Science.gov (United States)

    Atwal, Paldeep S; Macmurdo, C

    2015-12-01

    Features of Miller-Dieker syndrome (MDS, 17p13.3 deletion syndrome, LIS1-associated lissencephaly) include classic lissencephaly, microcephaly, cardiac malformations, growth restriction, and characteristic facial changes. Individuals with 22q11.2 deletion syndrome (DiGeorge syndrome or velocardiofacial syndrome) are known to have congenital cardiac malformations (in particular conotruncal defects), palatal abnormalities (especially velopharyngeal insufficiency), hypocalcemia, immune deficiency, learning disabilities, and characteristic facial features. This case report describes phenotypic characteristics of a patient with extremely rare instance of having both MDS and 22q11.2 deletion syndrome that is unique in the medical literature. Prognosis in this concurrent phenotype is poor with our patient suffering from several malformations seen in both conditions and expiring in the neonatal period.

  7. Better P-curves: Making P-curve analysis more robust to errors, fraud, and ambitious P-hacking, a Reply to Ulrich and Miller (2015).

    Science.gov (United States)

    Simonsohn, Uri; Simmons, Joseph P; Nelson, Leif D

    2015-12-01

    When studies examine true effects, they generate right-skewed p-curves, distributions of statistically significant results with more low (.01 s) than high (.04 s) p values. What else can cause a right-skewed p-curve? First, we consider the possibility that researchers report only the smallest significant p value (as conjectured by Ulrich & Miller, 2015), concluding that it is a very uncommon problem. We then consider more common problems, including (a) p-curvers selecting the wrong p values, (b) fake data, (c) honest errors, and (d) ambitiously p-hacked (beyond p < .05) results. We evaluate the impact of these common problems on the validity of p-curve analysis, and provide practical solutions that substantially increase its robustness. (c) 2015 APA, all rights reserved).

  8. Hydrologic conditions and water-quality conditions following underground coal mining in the North Fork of the Right Fork of Miller Creek drainage basin, Carbon and Emery Counties, Utah, 2004-2005

    Science.gov (United States)

    Wilkowske, C.D.; Cillessen, J.L.; Brinton, P.N.

    2007-01-01

    In 2004 and 2005, the U.S. Geological Survey, in cooperation with the Bureau of Land Management, reassessed the hydrologic system in and around the drainage basin of the North Fork of the Right Fork (NFRF) of Miller Creek, in Carbon and Emery Counties, Utah. The reassessment occurred 13 years after cessation of underground coal mining that was performed beneath private land at shallow depths (30 to 880 feet) beneath the NFRF of Miller Creek. This study is a follow-up to a previous USGS study of the effects of underground coal mining on the hydrologic system in the area from 1988 to 1992. The previous study concluded that mining related subsidence had impacted the hydrologic system through the loss of streamflow over reaches of the perennial portion of the stream, and through a significant increase in dissolved solids in the stream. The previous study also reported that no substantial differences in spring-water quality resulted from longwall mining, and that no clear relationship between mining subsidence and spring discharge existed.During the summers of 2004 and 2005, the USGS measured discharge and collected water-quality samples from springs and surface water at various locations in the NFRF of Miller Creek drainage basin, and maintained a streamflow-gaging station in the NFRF of Miller Creek. This study also utilized data collected by Cyprus–Plateau Mining Corporation from 1992 through 2001.Of thirteen monitored springs, five have discharge levels that have not returned to those observed prior to August 1988, which is when longwall coal mining began beneath the NFRF of Miller Creek. Discharge at two of these five springs appears to fluctuate with wet and dry cycles and is currently low due to a drought that occurred from 1999–2004. Discharge at two other of the five springs did not increase with increased precipitation during the mid-1990s, as was observed at other monitored springs. This suggests that flowpaths to these springs may have been altered by

  9. Morfo-anatomia do fruto (hipanto, pericarpo e semente em desenvolvimento de Pereskia aculeata Miller (Cactaceae - DOI: 10.4025/actascibiolsci.v25i2.2046 Morphology and anatomy of the fruit (hypanthium, pericarp and seed development of Pereskia aculeate Miller (Cactaceae

    Directory of Open Access Journals (Sweden)

    Sonia Maciel da Rosa

    2003-04-01

    Full Text Available O desenvolvimento do fruto (hipanto, pericarpo e semente de Pereskia aculeata Miller é analisado desde a flor em antese até a maturidade. A flor é perígina e apresenta no hipanto bractéolas verdes e acúleos. O fruto é pomáceo, tipo cactídio e caracteriza-se por apresentar hipanto carnoso, pericarpo e massa gelatinosa, formada pela destruição parcial do pericarpo e columela, onde estão imersas as sementes. A semente é exotestal e origina-se do óvulo anfítropo, bitegumentado e crassinucelado. A semente apresenta reserva perispérmica e resíduos de endosperma. O embrião é curvo e tem eixo hipocótilo-radicular longo, dois cotilédones com mesofilo homogêneo e plúmula indiferenciadaThe development of Pereskia aculeate Miller fruit (hypanthium, pericarp and seed was analyzed. The flower is perigynous and presents a hypanthium with bracteoles and aculeus. The fruit is pomaceous, type cactídio, with succulent hypanthium, pericarp, and seeds immersed in a gelatinous mass. This gelatinous mass originates from the pericarp and the columella. The seed is exotestal and develops from an amphitropous, bitegmic and crassinucelate ovule. It has perisperm and an endosperm residue. The embryo is curved and is composed of elongated hypocotyl-radicle axis, two cotyledons with uniform mesophyll, and undifferentiated plumule

  10. Wind farm development project at Mount Copper and Miller at Murdochville : public inquiry report; Projets d'amenagement des parcs d'eoliennes des monts Copper et Miller a Murdochville : rapport d'enquete et d'audience publique

    Energy Technology Data Exchange (ETDEWEB)

    Harvie, A.

    2004-03-01

    A public hearing was held at the request of the Quebec Minister of the Environment to examine the environmental and socio-economic impacts of a proposed wind farm project at Mount Copper and Mount Miller in Murdochville, Quebec. The first phase of the project involves the construction of a wind turbine array with a capacity of 9 megawatts (MW), followed by a second phase expansion to 45 MW for 2004. The final wind turbine array includes 36 turbines for a total capacity of 54 megawatts (MW). The region is well suited for wind energy projects. Energie Eolienne du Mont Miller Inc. and Northland Power Inc. intend to develop the wind farm at a cost of approximately $90 million. Hydro Quebec has agreed to purchase the electricity. The various impacts of the proposed project were examined, both from an environmental and a socio-economic perspective. The Commission determined that the wind farm would not have significant impacts and that the project is desirable. Certain conditions must be met to ensure sustainable development. In terms of ecology, the Commission would like to have a complete inventory of the bird species and a description of the corridors of migration. It would also like to see the promoters show leadership in minimizing the impacts of the project on the ecotourism activities offered in the area. 17 refs., 1 tab., 1 fig., 2 appendices.

  11. PENGGUNAAN SKEMA KONVEKTIF MODEL CUACA WRF (BETTS MILLER JANJIC, KAIN FRITSCH DAN GRELL 3D ENSEMBLE (Studi kasus: Surabaya dan Jakarta

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    Roni Kurniawan

    2015-01-01

    Full Text Available Pada kajian ini dilakukan evaluasi penggunaan beberapa skema konvektif pada model WRF (Weather Research and Forecasting untuk prediksi cuaca di wilayah Indonesia. Terdapat tiga skema konvektif yang akan dievaluasi yaitu; skema konvektif cumulus BMJ (Betts Miller Janjic, KF (Kain Fritsch, dan GD (Grell 3D ensemble. Data yang digunakan untuk evaluasi adalah data curah hujan per 3 jam dan data angin per 12 jam (level ketinggian; permukaan, 850, 500, 250 mb dari hasil pengolahan model WRF dan observasi selama periode bulan Agustus 2011 dan Februari 2012 di stasiun Juanda-Surabaya dan Cengkareng-Jakarta. Hasil verifikasi dari tiga skema konvektif pada model WRF terhadap data observasi menunjukkan bahwa untuk prakiraan curah hujan, penggunaan skema konvektif BMJ lebih baik dari skema KF dan GD, dan untuk prakiraan arah dan kecepatan angin skema BMJ dan GD relatif lebih baik dari skema KF. Berdasarkan analisis hasil verifikasi yang diperoleh, pemilihan skema konvektif cumulus BMJ cenderung lebih baik dari skema konvektif KF dan GD untuk di aplikasikan pada model WRF.   In this study, the use of some convective schemes on the model WRF (Weather Research and Forecasting for weather prediction in Indonesian region has been evaluated. There are two models evaluated; BMJ cumulus convective scheme (Betts Miller Janjic, KF (Kain Fritsch, and GD (Grell 3D ensemble. The data used in the evaluation are the 3 hourly rainfall data, and the 12 hourly wind data (level height; surface, 850, 500, 250mb from the WRF models and observation processing during August 2011 and February 2012 period at the Juanda-Surabaya and Cengkareng-Jakarta stations. The results of the verification of the three convective schemes in WRF models against observation data indicate that for precipitation forecasts, the application of the BMJ convective scheme is better than the KF and GD schemes, and for direction and wind speed forecast, BMJ and GD schemes is relatively better than the KF

  12. Características fisiológicas de microtomateiros fitocromo-mutantes Physiological characteristics of micro-tomato (Lycopersicon esculentum P. Miller phytochrome-mutants

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    Hyrandir Cabral de Melo

    2009-10-01

    Full Text Available Objetivou-se, neste trabalho, caracterizar aspectos fisiológicos de microtomateiros (Lycopersicon esculentum P. Miller cv. Micro-Tom fitocromo-mutantes. A cultivar Micro-Tom e os mutantes aurea (deficiente na biossíntese do cromóforo dos fitocromos, atroviolacea (atv e high pigment1 (hp1;ambos superexpressam eventos mediados por fitocromos foram cultivados em condições controladas de luz e temperatura e caracterizados no estágio de floração. O mutante hp1 obteve as maiores taxas de fotossíntese potencial e de conteúdo de carotenóides. O mutante aurea manteve taxas de fotossíntese potencial similares à cultivar Micro-Tom, mesmo expressando o mais baixo conteúdo de clorofilas, e também expressou o maior conteúdo de nitrogênio entre os demais microtomateiros. Os mutantes aurea e hp1 obtiveram os menores conteúdos de açúcares solúveis totais. O mutante atv expressou o maior conteúdo de clorofilas e também a menor razão clorofila a/b.The objective of this work was to characterize physiological aspects of micro-tomato (Lycopersicon esculentum P. Miller cv. Micro-Tom phytochrome-mutants. Plants of Micro-Tom cultivar and aurea (deficient in phytochrome chromophore biosynthesis, high pigment1 (hp1 and atroviolacea (atv (both super express phytochrome events-mediated mutants were cultivated under controlled light and temperature and evaluated in flowering stage. The hp1 mutant expressed the highest rates of potential photosynthesis and also the content of total carotenoids. Aurea mutant maintained similar potential photosynthesis rates as the Micro-Tom cultivar, even containing low chlorophyll content, and expressed the highest content of nitrogen among all micro-tomatoes studied. Total soluble sugars were lower in aurea and hp1 mutants. The atv mutant expressed the highest content of chlorophylls and also the lowest rate of chlorophyll a/b.

  13. Evaluation of efficacy of a novel resorbable collagen membrane for root coverage of Miller's Class I and Class II recession in the maxillary anteriors and premolars

    Directory of Open Access Journals (Sweden)

    Krutika Kapare

    2016-01-01

    Full Text Available Background: There are several surgical techniques in literature that have been used to perform root coverage (RC. Currently, the use of a resorbable collagen membrane (RCM as a guided tissue regenerative material is one of the highly sought treatment modalities. The present study aimed at evaluating the clinical outcome of RC in the treatment of Miller's Class I and II recession defects in maxillary anteriors and premolars by coronally advanced flap (CAF with and without RCM. Materials and Methods: This split-mouth study (bilateral buccal recession defects was randomized to include 15 test (CAF + membrane and 15 control (CAF alone sites. Clinical parameters included gingival recession depth (RD, probing pocket depth (PPD, clinical attachment level (CAL, and keratinized tissue height (KTH measured at baseline and 9 months postoperatively. Results: Both test and control groups showed statistically significant (P < 0.05 reductions in RD (1.54 ± 0.46 mm and 1.60 ± 0.07 mm, PPD (0.53 ± 0.15 mm and 0.94 ± 0.10 mm, increase in KTH (0.67 ± 0.90 mm and 0.73 ± 0.14 mm and CAL (1.94 ± 0.27 mm and 2.60 ± 0.19 mm when comparing the 9-month data from baseline. The present study showed that mean improvement in RD was 1.60 ± 0.507 and 1.53 ± 0.64 mm in both test and control groups, respectively. Mean percent RC was 58.33% ±12.19% and 56.22% ±10.22% for test and control groups, respectively. However, there were no statistically significant differences between groups for RD, PPD, KTH, and CAL. Conclusion: The results of this study suggest that both the groups CAF (control and CAF and RCM (test could be successfully used to treat Miller's Class I and II gingival recession defects and also demonstrated an overall significant improvement in all the assessed clinical parameters. However, there was a greater reduction of gingival RD with the use of RCM when compared with the group of CAF alone.

  14. Realization of the Atkinson-Miller cycle in spark-ignition engine by means of the fully variable inlet valve control system

    Science.gov (United States)

    Żmudka, Zbigniew; Postrzednik, Stefan; Przybyła, Grzegorz

    2014-09-01

    The theoretical analysis of the charge exchange process in a spark ignition engine has been presented. This process has significant impact on the effectiveness of engine operation because it is related to the necessity of overcoming the flow resistance, followed by the necessity of doing a work, so-called the charge exchange work. The flow resistance caused by the throttling valve is especially high during the part load operation. The open Atkinson-Miller cycle has been assumed as a model of processes taking place in the engine. Using fully variable inlet valve timing the A-M cycle can be realized according to two systems: system with late inlet valve closing and system with early inlet valve closing. The systems have been analysed individually and comparatively with the open Seiliger-Sabathe cycle which is a theoretical cycle for the classical throttle governing of the engine load. Benefits resulting from application of the systems with independent inlet valve control have been assessed on the basis of the selected parameters: fuel dose, cycle work, charge exchange work and a cycle efficiency. The use of the analysed systems to governing of the SI engine load will enable to eliminate a throttling valve from the system inlet and reduce the charge exchange work, especially within the range of part load operation.

  15. Realization of the Atkinson-Miller cycle in spark-ignition engine by means of the fully variable inlet valve control system

    Directory of Open Access Journals (Sweden)

    Żmudka Zbigniew

    2014-09-01

    Full Text Available The theoretical analysis of the charge exchange process in a spark ignition engine has been presented. This process has significant impact on the effectiveness of engine operation because it is related to the necessity of overcoming the flow resistance, followed by the necessity of doing a work, so-called the charge exchange work. The flow resistance caused by the throttling valve is especially high during the part load operation. The open Atkinson-Miller cycle has been assumed as a model of processes taking place in the engine. Using fully variable inlet valve timing the A-M cycle can be realized according to two systems: system with late inlet valve closing and system with early inlet valve closing. The systems have been analysed individually and comparatively with the open Seiliger-Sabathe cycle which is a theoretical cycle for the classical throttle governing of the engine load. Benefits resulting from application of the systems with independent inlet valve control have been assessed on the basis of the selected parameters: fuel dose, cycle work, charge exchange work and a cycle efficiency. The use of the analysed systems to governing of the SI engine load will enable to eliminate a throttling valve from the system inlet and reduce the charge exchange work, especially within the range of part load operation.

  16. Petrogenesis of Miller Range 07273, a new type of anomalous melt breccia: Implications for impact effects on the H chondrite asteroid

    Science.gov (United States)

    Ruzicka, Alex M.; Hutson, Melinda; Friedrich, Jon M.; Rivers, Mark L.; Weisberg, Michael K.; Ebel, Denton S.; Ziegler, Karen; Rumble, Douglas; Dolan, Alyssa A.

    2017-09-01

    Miller Range 07273 is a chondritic melt breccia that contains clasts of equilibrated ordinary chondrite set in a fine-grained (shapes for coarse metal grains, unusual internal textures and compositions for coarse metal, a matrix composed chiefly of clinoenstatite and omphacitic pigeonite, and troilite veining most common in coarse olivine and orthopyroxene. These features can be explained by a model involving impact into a porous target that produced brief but intense heating at high pressure, a sudden pressure drop, and a slower drop in temperature. Olivine and orthopyroxene in chondrule clasts were the least melted and the most deformed, whereas matrix and troilite melted completely and crystallized to nearly strain-free minerals. Coarse metal was largely but incompletely liquefied, and matrix silicates formed by the breakdown during melting of albitic feldspar and some olivine to form pyroxene at high pressure (>3 GPa, possibly to 15-19 GPa) and temperature (>1350 °C, possibly to ≥2000 °C). The higher pressures and temperatures would have involved back-reaction of high-pressure polymorphs to pyroxene and olivine upon cooling. Silicates outside of melt matrix have compositions that were relatively unchanged owing to brief heating duration.

  17. Paleogeographic significance of Clavohamulus hintzei Miller (Conodonta) and other Ibexian conodonts in an early Paleozoic carbonate platform facies of the Argentine Precordillera

    Science.gov (United States)

    Lehnert, O.; Miller, J.F.; Repetski, J.E.

    1997-01-01

    Pre-Tremadocian conodonts and trilobites and Tremadocian conodonts are reported from the Cambrian and Ordovician La Silla Formation in the Cerro La Silla section in east-southeast Ja??chal, San Juan Province, Argentina. A shallow marine conodont fauna contains elements of Clavohamulus hintzei Miller, a common species in North America, but reported for the first time from the early Paleozoic platform carbonates of the western Argentine Precordillera. The presence of this species suggests a correlation with the Clavohamulus hintzei conodont subbiozone of the Cordylodus intermedius conodont biozone in North America, considered Early Ordovician (Skullrockian Stage, Ibexian Series) in North America, but by South American and European standards, this biozone would be of latest Cambrian age. C. hintzei and associated conodonts of the La Silla Formation are typical of the tropical faunas of the North American Midcontinent Faunal Province; Late Cambrian trilobites from lower in the formation also are typical North American taxa. The presence of these faunas in the platform carbonates is consistent with plate reconstructions suggesting that the Precordillera was in a tropical or subtropical position close to Laurentia during the late Precambrian and early Paleozoic. These new paleontological data provide one more argument for recent models of the Precordillera as a displaced terrane derived from the Ouachita Embayment at the southern margin of Laurentia.

  18. First molecular identification of Australapatemon burti (Miller, 1923) (Trematoda: Digenea: Strigeidae) from an intermediate host Radix labiata (Rossmaessler) (Gastropoda: Lymnaeidae) in Europe.

    Science.gov (United States)

    Aksenova, Olga V; Bespalaya, Yulia V; Bolotov, Ivan N; Kondakov, Alexander V; Sokolova, Svetlana E

    2016-07-01

    The strigeid digenean species Australapatemon burti (Miller, 1923) (Trematoda: Digenea: Strigeidae) was originally described from North America, but recorded in the Neotropical region (Drago et al. 2007; Hernández-Mena et al. 2014; Blasco-Costa et al. 2016) and in Central Europe (Faltýnková et al. 2007). In Europe, this species is rare, and there is not much information about its range (Faltýnková et al. 2007; Soldánová et al. 2012). Australapatemon burti has a complex life cycle with three larval stages, two of which (sporocyst and cercaria) use several species of freshwater snails, and the third stage (metacercaria) use non-specific host hirudineans (Dubois 1968; Davies & Ostrowski de Núñez 2012; Blasco-Costa et al. 2016). Adult flukes are parasitic in the intenstines of various waterfowl species, such as ducks and swans (Drago et al. 2007; Hernández-Mena et al. 2014). Currently, the molecular data on this parasite species includes only nucleotide sequences of four adult specimens from Mexico (Hernández-Mena et al. 2014). Their hosts were Mexican duck, Anas diazi Ridgway, American Wigeon, Anas americana Gmelin, Cinnamon Teal, Anas cyanoptera Vieillot, and Ruddy Duck, Oxyura jamaicensis (Gmelin) (Anserformes: Anatidae).

  19. Molecular dissection of a contiguous gene syndrome: Frequent submicroscopic deletions, evolutionarily conserved sequences, and a hypomethylated island in the Miller-Dieker chromosome region

    International Nuclear Information System (INIS)

    Ledbetter, D.H.; Ledbetter, S.A.; vanTuinen, P.

    1989-01-01

    The Miller-Dieker syndrome (MDS), composed of characteristic facial abnormalities and a severe neuronal migration disorder affecting the cerebral cortex, is caused by visible or submicroscopic deletions of chromosome band 17p13. Twelve anonymous DNA markers were tested against a panel of somatic cell hybrids containing 17p deletions from seven MDS patients. All patients, including three with normal karyotypes, are deleted for a variable set of 5-12 markers. Two highly polymorphic VNTR (variable number of tandem repeats) probes, YNZ22 and YNH37, are codeleted in all patients tested and make molecular diagnosis for this disorder feasible. By pulsed-field gel electrophoresis, YNZ22 and YNH37 were shown to be within 30 kilobases (kb) of each other. Cosmid clones containing both VNTR sequences were identified, and restriction mapping showed them to be 100 kb were completely deleted in all patients, providing a minimum estimate of the size of the MDS critical region. A hypomethylated island and evolutionarily conserved sequences were identified within this 100-kb region, indications of the presence of one or more expressed sequences potentially involved in the pathophysiology of this disorder. The conserved sequences were mapped to mouse chromosome 11 by using mouse-rat somatic cell hybrids, extending the remarkable homology between human chromosome 17 and mouse chromosome 11 by 30 centimorgans, into the 17p telomere region

  20. Yale University's Institute of Human Relations and the Spanish Civil War: Dollard and Miller's study of fear and courage under battle conditions.

    Science.gov (United States)

    Gondra, José María; Sánchez de Miguel, Manuel

    2009-11-01

    In the late 1930s, the Institute of Human Relations of Yale University developed a research program on conflict and anxiety as an outcome of Clark Hull's informal seminar on the integration of Freud's and Pavlov's theories. The program was launched at the 1937 Annual Meeting of the APA in a session chaired by Clark L. Hull, and the experiments continued through 1941, when the United States entered the Second World War. In an effort to apply the findings from animal experiments to the war situation, John Dollard and Neal E. Miller decided to study soldiers' fear reactions in combat. As a first step, they arranged interviews with a few veterans of the Abraham Lincoln Brigade. Taking these interviews as a point of departure, Dollard devised a questionnaire to which 300 former Lincoln brigaders responded. The present paper analyzes the main outcomes of the questionnaire, together with the war experiences reported in the interview transcripts. Our purpose was to evaluate a project which was initially investigated by the FBI because of the communists among the Lincoln ranks, but eventually supported by the American Army, and which exerted great influence on the military psychology of the time.

  1. Bickerstaff’s brainstem encephalitis, Miller Fisher syndrome and Guillain-Barré syndrome overlap in an asthma patient with negative anti-ganglioside antibodies

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    Han Chongyu

    2012-06-01

    Full Text Available Abstract Background Bickerstaff’s brainstem encephalitis (BBE, together with Miller Fisher syndrome (MFS and Guillain-Barré syndrome (GBS were considered to form a continuous clinical spectrum. An anti-GQ1b antibody syndrome has been proposed to underlie the common pathophysiology for the three disorders; however, other studies have found a positive anti-GM1 instead of anti-GQ1b antibody. Case presentation Here we report a 20-year-old male patient with overlapping BBE, MFS and GBS. The patient had a positive family history of bronchial asthma and had suffered from the condition for over 15 years. He developed BBE symptoms nine days after an asthma exacerbation. During the course of illness, he had significantly elevated IgE levels in both serum and cerebrospinal fluid. Serologic analysis of antibodies against ganglioside complexes (anti-GDIa, anti-GDIb, anti-GM1, anti-GM2, anti-GM3, anti-GQIb and anti-GTIb antibodies showed negative results. Conclusions Since asthma has recently been related to autoimmune disease, our case supports an autoimmune mechanism underlying the clinical spectrum composed of BBE, MFS and GBS. However, contrary to a proposed anti-GQ1b antibody syndrome, we would suggest that pathogenesis of this clinical spectrum is not limited to anti-ganglioside antibodies.

  2. Prenatal diagnosis of monosomy 17p (17p13.3-->pter) associated with polyhydramnios, intrauterine growth restriction, ventriculomegaly, and Miller-Dieker lissencephaly syndrome in a fetus.

    Science.gov (United States)

    Lin, Chin-Yi; Chen, Chih-Ping; Liau, Chiung-Ling; Su, Pen-Hua; Tsao, Teng-Fu; Chang, Tung-Yao; Wang, Wayseen

    2009-12-01

    To present the prenatal magnetic resonance imaging (MRI) and ultrasound findings of Miller-Dieker lissencephaly syndrome (MDLS) associated with chromosome 17p13.3 deletion in a fetus. A 30-year-old, primigravid woman was referred to the hospital at 31 weeks' gestation because of intrauterine growth restriction (IUGR) and polyhydramnios detected by ultrasound. The pregnancy was uneventful until 31 weeks of gestation when IUGR and polyhydramnios were first noted. Level II ultrasound at 31 weeks' gestation showed fetal biometry equivalent to 27 weeks' gestation, an amniotic fluid index of 33.4 cm, ventriculomegaly, and abnormal sulcal development with absence of gyri and sulci, and a shallow Sylvian fissure. Other organs were unremarkable. Subsequent amniocentesis revealed a 46,XY,del(17)(p13.3) karyotype. Ultrafast fetal MRI performed at 34 weeks of gestation revealed agyria/pachygyria, a figure-eight appearance of the brain, a wide and shallow Sylvian fissure, enlarged subarachnoid space, ventriculomegaly, and polyhydramnios. At 35 weeks' gestation, a 1,346-g male baby was delivered with facial dysmorphism, characteristic of MDLS. Postnatal MRI confirmed the prenatal diagnosis. Polyhydramnios, IUGR and ventriculomegaly are important prenatal ultrasound markers of MDLS. Prenatal diagnosis of these markers should include a detailed investigation of cerebral sulci and fissures, and genetic analysis for MDLS. Fetal MRI is helpful for the diagnosis of lissencephaly.

  3. Prebiotic Synthesis of Methionine and Other Sulfur-Containing Organic Compounds on the Primitive Earth: A Contemporary Reassessment Based on an Unpublished 1958 Stanley Miller Experiment

    Science.gov (United States)

    Parker, Eric T.; Cleaves, H. James; Callahan, Michael P.; Dworkin, Jason P.; Glavin, Daniel P.; Lazcano, Antonio

    2010-01-01

    Original extracts from an unpublished 1958 experiment conducted by the late Stanley L. Miller were recently found and analyzed using modern state-of-the-art analytical methods. The extracts were produced by the action of an electric discharge on a mixture of methane (CH4), hydrogen sulfide (H2S), ammonia (NH3), and carbon dioxide (CO2). Racemic methionine was farmed in significant yields, together with other sulfur-bearing organic compounds. The formation of methionine and other compounds from a model prebiotic atmosphere that contained H2S suggests that this type of synthesis is robust under reducing conditions, which may have existed either in the global primitive atmosphere or in localized volcanic environments on the early Earth. The presence of a wide array of sulfur-containing organic compounds produced by the decomposition of methionine and cysteine indicates that in addition to abiotic synthetic processes, degradation of organic compounds on the primordial Earth could have been important in diversifying the inventory of molecules of biochemical significance not readily formed from other abiotic reactions, or derived from extraterrestrial delivery.

  4. Temperature profiles from expendable bathythermograph (XBT) casts from NOAA Ship MILLER FREEMAN and USS O'BANNON in the North Atlantic Ocean and North Pacific Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 1984-02-04 to 1984-02-28 (NODC Accession 8400054)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from NOAA Ship MILLER FREEMAN and USS O'BANNON in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected...

  5. Temperature profiles from expendable bathythermograph (XBT) casts from NOAA Ship MILLER FREEMAN in the Gulf of Alaska and North Pacific Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 1985-05-30 to 1985-06-02 (NODC Accession 8500140)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from NOAA Ship MILLER FREEMAN in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected by the National...

  6. Temperature profiles from expendable bathythermograph (XBT) casts from NOAA Ship MILLER FREEMAN in the Gulf of Alaska in support of the Integrated Global Ocean Services System (IGOSS) project from 1984-05-29 to 1984-05-30 (NODC Accession 8400116)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from NOAA Ship MILLER FREEMAN in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected by the National...

  7. Temperature and salinity profiles from expendable bathythermograph (XBT) and CTD casts from NOAA Ship MILLER FREEMAN and other Platforms from Coastal Waters of Washington/Oregon and other locations in support of the Integrated Global Ocean Services System (IGOSS) from 1977-07-12 to 1983-07-26 (NODC Accession 8300102)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT and CTD data were collected from NOAA Ship MILLER FREEMAN and other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project. Data...

  8. Dissolved inorganic carbon, pH, alkalinity, temperature, salinity and Calcium collected from discrete sample and profile observations using CTD, bottle and other instruments from NOAA Ship MILLER FREEMAN in the North Pacific Ocean and South Pacific Ocean from 1979-04-01 to 1982-06-30 (NODC Accession 0000180)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0000180 includes chemical, discrete sample, physical and profile data collected from NOAA Ship MILLER FREEMAN in the North Pacific Ocean and South...

  9. Temperature and salinity profiles from CTD casts from NOAA Ship MILLER FREEMAN and other PLATFORMS from the North Pacific Ocean and North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) from 1991-10-01 to 1991-10-31 (NODC Accession 9100209)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  10. Bioprospección de hongos micorrízicos arbusculares como alternativa para el fortalecimiento del cultivo de aguacate (Persea americana Miller en Colombia

    Directory of Open Access Journals (Sweden)

    Sandra Patricia Montenegro Gómez

    2017-06-01

    Full Text Available El Aguacate (Persea americana Miller es uno de los frutos de mayor consumo mundial. México es el principal productor y  actualmente afronta problemas como el ataque de patógenos a la raíz y recientemente se han registrado impactos en la salud humana por uso de agroquímicos. Una alternativa para afrontar problemáticas en el desarrollo de las plantas ha sido iniciar el correcto manejo de las primeras etapas de producción y con ello mitigar problemas posteriores, en este manejo los microorganismos juegan un papel fundamental. Uno de los métodos es la inoculación con microorganismos del suelo como los hongos micorrízicos arbusculares (HMA; diversos estudios han demostrado que su colonización radicular en las plantas contribuye con la absorción de agua y nutrientes; lo cual indica que su potencialización puede contribuir en el manejo sustentable de los cultivos y como opción para fortalecer la producción. Colombia ocupa el quinto lugar en productividad a nivel mundial y lo que más resta competitividad local es el costo de los agroinsumos; en este sentido se podrían fortalecer investigaciones encaminadas a la bioprospección de HMA específicos para diversas variedades de aguacate en las regiones colombianas, ya que son poco los avances en esta temática. Avanzar tecnológicamente en el manejo de cultivos y generar estrategias sostenibles hace parte de las perspectivas y retos de la cadena del aguacate en Colombia. Adicionalmente es prioritario entrar en la dinámica de la demanda mundial con preferencia de alimentos más sanos y cuya producción sea amigable con el medio ambiente.

  11. UMTRA water sampling technical (peer) review. Responses to observations, comments, and recommendations submitted by C. Warren Ankerberg (Geraghty ampersand Miller, Inc.)

    International Nuclear Information System (INIS)

    1993-08-01

    At the request of the Office of Independent Technical Review for the U.S. Department of Energy (DOE), Uranium Mill Tailings Remedial Action (UMTRA) Project, an independent technical review (peer review) was conducted during the period of September 15-17, 1992. The review was conducted by C. Warren Ankerberg (Geraghty ampersand Miller, Inc., Tampa, Florida) and Don Messinger (Roy F. Weston, Inc., West Chester, Pennsylvania). The peer review included a review of written documentation [water sampling standard operating procedures (SOP)], an inspection of technical reports and other deliverables, a review of staff qualifications and training, and a field visit to evaluate the compliance of field procedures with SOPs. The approach of the peer reviewers was to verify that the program meets the following criteria: Reported results are traceable to and consistent with recorded data. The basic assumptions and acceptance criteria are valid. Data are traceable to their origin and to reported analytical results. The procedures employed are consistent both internally and externally with written SOPs and regulatory guidelines. Inferences and conclusions are soundly based. The procedures and/or reports generated present work that satisfies the local, state and/or Federal regulatory requirements as applicable. The approach is consistent with industry standards and/or state-of-the-art technology, as practical. The data generated by activities are legally defensible and technically sound. UMTRA staff are adequately trained and qualified for the work. This document is a response to the observations, comments, and recommendations submitted by C. Warren Ankerberg following his review. The format of this document is to present the findings and recommendations verbatim from Mr. Ankerberg's report, followed by responses from the UMTRA Project staff. Included in the responses from the UMTRA Project staff are recommended changes in SOPs and strategies for implementing the changes

  12. Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition

    International Nuclear Information System (INIS)

    Essafi-Benkhadir, Khadija; Refai, Amira; Riahi, Ichrak; Fattouch, Sami; Karoui, Habib; Essafi, Makram

    2012-01-01

    Highlights: ► Quince peel polyphenols inhibit LPS-induced secretion of TNF-α and IL-8. ► Quince peel polyphenols augment LPS-induced secretion of IL-10 and IL-6. ► Quince peel polyphenols-mediated inhibition of LPS-induced secretion of TNF-α is partially mediated by IL-6. ► The anti-inflammatory effects of quince polyphenols pass through NF-κB, p38MAPK and Akt inhibition. -- Abstract: Chronic inflammation is a hallmark of several pathologies, such as rheumatoid arthritis, gastritis, inflammatory bowel disease, atherosclerosis and cancer. A wide range of anti-inflammatory chemicals have been used to treat such diseases while presenting high toxicity and numerous side effects. Here, we report the anti-inflammatory effect of a non-toxic, cost-effective natural agent, polyphenolic extract from the Tunisian quince Cydonia oblonga Miller. Lipopolysaccharide (LPS) treatment of human THP-1-derived macrophages induced the secretion of high levels of the pro-inflammatory cytokine TNF-α and the chemokine IL-8, which was inhibited by quince peel polyphenolic extract in a dose-dependent manner. Concomitantly, quince polyphenols enhanced the level of the anti-inflammatory cytokine IL-10 secreted by LPS-treated macrophages. We further demonstrated that the unexpected increase in IL-6 secretion that occurred when quince polyphenols were associated with LPS treatment was partially responsible for the polyphenols-mediated inhibition of TNF-α secretion. Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-κB), p38MAPK and Akt. Overall, our data indicate that quince peel polyphenolic extract induces a potent anti-inflammatory effect that may prove useful for the treatment of inflammatory diseases and that a quince-rich regimen may help to prevent and improve the treatment of such diseases.

  13. WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations

    Directory of Open Access Journals (Sweden)

    Gennaro Riccio

    2017-11-01

    Full Text Available Inhibitors of the Wingless-related Integration site (WNT/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP. This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv. ‘Annurca’ and Malus domestica cv ‘Limoncella’; (ii identify the mechanisms underpinning their activities and; (iii evaluate their potency upon gastrointestinal digestion. We here show that both Annurca and Limoncella apple extracts act as WNT inhibitors, mostly thanks to their polyphenolic contents. They inhibit the pathway in colon cells carrying FAP mutations with active dilutions falling in ranges close to consumer-relevant concentrations. Food-grade manufacturing of apple extracts increases their WNT inhibitory activity as result of the conversion of quercetin glycosides into the aglycone quercetin, a potent WNT inhibitor absent in the fresh fruit extract. However, in vitro simulated gastrointestinal digestion severely affected WNT inhibitory activity of apple extracts, as result of a loss of polyphenols. In conclusion, our results show that apple extracts inhibit the WNT pathway in colon cells carrying FAP mutations and represent a potential nutraceutical alternative for the treatment of this pathology. Enteric coating is advisable to preserve the activity of the extracts in the colon-rectal section of the digestive tract.

  14. WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations.

    Science.gov (United States)

    Riccio, Gennaro; Maisto, Maria; Bottone, Sara; Badolati, Nadia; Rossi, Giovanni Battista; Tenore, Gian Carlo; Stornaiuolo, Mariano; Novellino, Ettore

    2017-11-18

    Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv. 'Annurca' and Malus domestica cv 'Limoncella'; (ii) identify the mechanisms underpinning their activities and; (iii) evaluate their potency upon gastrointestinal digestion. We here show that both Annurca and Limoncella apple extracts act as WNT inhibitors, mostly thanks to their polyphenolic contents. They inhibit the pathway in colon cells carrying FAP mutations with active dilutions falling in ranges close to consumer-relevant concentrations. Food-grade manufacturing of apple extracts increases their WNT inhibitory activity as result of the conversion of quercetin glycosides into the aglycone quercetin, a potent WNT inhibitor absent in the fresh fruit extract. However, in vitro simulated gastrointestinal digestion severely affected WNT inhibitory activity of apple extracts, as result of a loss of polyphenols. In conclusion, our results show that apple extracts inhibit the WNT pathway in colon cells carrying FAP mutations and represent a potential nutraceutical alternative for the treatment of this pathology. Enteric coating is advisable to preserve the activity of the extracts in the colon-rectal section of the digestive tract.

  15. Chemical Composition and Acaricidal Effects of Essential Oils of Foeniculum vulgare Mill. (Apiales: Apiaceae and Lavandula angustifolia Miller (Lamiales: Lamiaceae against Tetranychus urticae Koch (Acari: Tetranychidae

    Directory of Open Access Journals (Sweden)

    Asgar Ebadollahi

    2014-01-01

    Full Text Available Utilization of synthetic acaricides causes negative side-effects on nontarget organisms and environment and most of the mite species such as two spotted spider mite, Tetranychus urticae Koch, are becoming resistant to these chemicals. In the present study, essential oils of fennel, Foeniculum vulgare Mill., and lavender, Lavandula angustifolia Miller, were hydrodistilled using Clevenger apparatus and chemical composition of these oils was analyzed by GC-MS. Anethole (46.73%, limonene (13.65%, and α-fenchone (8.27% in the fennel essential oil and linalool (28.63%, 1,8-cineole (18.65%, and 1-borneol (15.94% in the lavender essential oil were found as main components. Contact and fumigant toxicity of essential oils was assessed against adult females of T. urticae after 24 h exposure time. The essential oils revealed strong toxicity in both contact and fumigant bioassays and the activity dependeds on essential oil concentrations. Lethal concentration 50% for the population of mite (LC50 was found as 0.557% (0.445–0.716 and 0.792% (0.598–1.091 in the contact toxicity and 1.876 μL/L air (1.786–1.982 and 1.971 μL/L air (1.628–2.478 in the fumigant toxicity for fennel and lavender oils, respectively. Results indicated that F. vulgare and L. angustifolia essential oils might be useful for managing of two spotted spider mite, T. urticae.

  16. Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats

    Science.gov (United States)

    Boudreau, Mary D.

    2013-01-01

    Aloe barbadensis Miller (Aloe vera) is an herbal remedy promoted to treat a variety of illnesses; however, only limited data are available on the safety of this dietary supplement. Drinking water exposure of F344/N rats and B6C3F1 mice to an Aloe vera whole-leaf extract (1, 2, and 3%) for 13 weeks resulted in goblet cell hyperplasia of the large intestine in both species. Based upon this observation, 2-year drinking water studies were conducted to assess the carcinogenic potential of an Aloe vera whole-leaf extract when administered to F344/N rats (48 per sex per group) at 0.5, 1, and 1.5%, and B6C3F1 mice (48 per sex per group) at 1, 2, and 3%. Compared with controls, survival was decreased in the 1.5% dose group of female rats. Treatment-related neoplasms and nonneoplastic lesions in both species were confined primarily to the large intestine. Incidences of adenomas and/or carcinomas of the ileo-cecal and cecal-colic junction, cecum, and ascending and transverse colon were significantly higher than controls in male and female rats in the 1 and 1.5% dose groups. There were no neoplasms of the large intestine in mice or in the 0 or 0.5% dose groups of rats. Increased incidences of mucosa hyperplasia of the large intestine were observed in F344/N rats, and increased incidences of goblet cell hyperplasia of the large intestine occurred in B6C3F1 mice. These results indicate that Aloe vera whole-leaf extract is an intestinal irritant in F344/N rats and B6C3F1 mice and a carcinogen of the large intestine in F344/N rats. PMID:22968693

  17. Hydrogeochemical modelling of fluid–rock interactions triggered by seawater injection into oil reservoirs: Case study Miller field (UK North Sea)

    International Nuclear Information System (INIS)

    Fu, Yunjiao; Berk, Wolfgang van; Schulz, Hans-Martin

    2012-01-01

    A hydrogeochemical model is presented and applied to quantitatively elucidate interdependent reactions among minerals and formation water–seawater mixtures at elevated levels of CO 2 partial pressure. These hydrogeochemical reactions (including scale formation) occur within reservoir aquifers and wells and are driven by seawater injection. The model relies on chemical equilibrium thermodynamics and reproduces the compositional development of the produced water (formation water–seawater mixtures) of the Miller field, UK North Sea. This composition of the produced water deviates from its calculated composition, which could result solely from mixing of both the end members (formation water and seawater). This indicates the effect of hydrogeochemical reactions leading to the formation and/or the dissolution of mineral phases. A fairly good match between the modelled and measured chemical composition of produced water indicates that hydrogeochemical interactions achieve near-equilibrium conditions within the residence time of formation water–seawater mixtures at reservoir conditions. Hence the model enables identification of minerals (including scale minerals), to quantitatively reproduce and to predict their dissolution and/or formation. The modelling results indicate that admixing of seawater into formation water triggers the precipitation of Sr–Barite solid solution, CaSO 4 phases and dolomite. In contrast, calcite and microcrystalline quartz are dissolved along the seawater flow path from the injection well towards the production well. Depending on the fraction of seawater admixed, interdependent reactions induce profound modifications to the aquifer mineral phase assemblage. At low levels of seawater admixture, Ba–Sr sulfate solid solution is precipitated and coupled to concurrent dissolution of calcite and microcrystalline quartz. Massive dissolution of calcite and the formation of CaSO 4 phases and dolomite are triggered by intense seawater admixture

  18. The Miller cycle effects on improvement of fuel economy in a highly boosted, high compression ratio, direct-injection gasoline engine: EIVC vs. LIVC

    International Nuclear Information System (INIS)

    Li, Tie; Gao, Yi; Wang, Jiasheng; Chen, Ziqian

    2014-01-01

    Highlights: • At high load, LIVC is superior over EIVC in improving fuel economy. • The improvement with LIVC is due to advanced combustion phasing and increased pumping work. • At low load, EIVC is better than LIVC in improving fuel economy. • Pumping loss with EIVC is smaller than with LIVC at low load. • But heat release rate with EIVC is slower than with LIVC. - Abstract: A combination of downsizing, highly boosting and direct injection (DI) is an effective way to improve fuel economy of gasoline engines without the penalties of reduced torque or power output. At high loads, however, knock problem becomes severer when increasing the intake boosting. As a compromise, geometric compression ratio (CR) is usually reduced to mitigate knock, and the improvement of fuel economy is discounted. Application of Miller cycle, which can be realized by either early or late intake valve closing (EIVC or LIVC), has the potential to reduce the effective CR and suppress knock. In this paper, the effects of EIVC and LIVC on the fuel economy of a boosted DI gasoline production engine reformed with a geometric CR of 12.0 are experimentally compared at low and high loads. Compared to the original production engine with CR 9.3, at the high load operation, the brake specific fuel consumption (BSFC) is improved by 4.7% with CR12.0 and LIVC, while the effect of EIVC on improving BSFC is negligibly small. At the low load operation, combined with CR12.0, LIVC and EIVC improve the fuel economy by 6.8% and 7.4%, respectively, compared to the production engine. The mechanism behind the effects of LIVC and EIVC on improving the fuel economy is discussed. These results will be a valuable reference for engine designers and researchers

  19. Likelihood of obtaining Structured Interview of Reported Symptoms (SIRS) and SIRS-2 elevations among forensic psychiatric inpatients with screening elevations on the Miller Forensic Assessment of Symptoms Test.

    Science.gov (United States)

    Glassmire, David M; Tarescavage, Anthony M; Gottfried, Emily D

    2016-12-01

    The Miller Forensic Assessment of Symptoms Test (M-FAST) was designed as a screening measure for feigned psychiatric symptoms. When M-FAST Total Scores are elevated (raw score ≥6), the test manual recommends follow-up with a more comprehensive measure of feigning, such as the widely used and researched Structured Interview of Reported Symptoms (SIRS) or the revised version of the test (SIRS-2). The purpose of the current study was to evaluate how often M-FAST screening elevations are associated with subsequent elevations on the SIRS or SIRS-2. The sample included archival data from 100 forensic psychiatric inpatients who obtained M-FAST Total Score elevations ≥6 during screening and were subsequently administered the SIRS (that was also rescored using SIRS-2 criteria). Among examinees who elevated the M-FAST over the recommended cutoff, 66.0% met standard SIRS feigning criteria, 42% met SIRS-2 criteria for feigning, and 81.0% obtained at least 1 SIRS/SIRS-2 elevation in the Probable Feigning range or higher. These results are consistent with the M-FAST manual guidelines, which support the use of the ≥6 M-FAST cutoff score to screen for potential feigning (but not as an independent marker of feigning). A higher M-FAST cutoff score of ≥16 was associated with subsequently meeting full SIRS criteria for feigning in 100.0% of protocols. Because the SIRS criteria were designed to have very low false positive rates, these findings indicate that more confident assertions about feigning can be made when elevations reach this level on the MFAST. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  20. Hydrology of the North Fork of the Right Fork of Miller Creek, Carbon County, Utah, before, during, and after underground coal mining

    Science.gov (United States)

    Slaughter, C.B.; Freethey, G.W.; Spangler, L.E.

    1995-01-01

    From 1988-92 the U.S. Geological Survey, in cooperation with the Utah Division of Oil, Gas, and Mining, studied the effects of underground coal mining and the resulting subsidence on the hydrologic system near the North Fork of the Right Fork of Miller Creek, Carbon County, Utah. The subsidence caused open fractures at land surface, debris slides, and rockfalls in the canyon above the mined area. Land surface subsided and moved several feet horizontally. The perennial stream and a tributary upstream from the mined area were diverted below the ground by surface fractures where the overburden thickness above the Wattis coal seam is 300 to 500 feet. The reach downstream was dry but flow resumed where the channel traversed the Star Point Sandstone, which forms the aquifer below the coal seams where ground-water discharge provides new base flow. Concentrations of dissolved constituents in the stream water sampled just downstream from the mined area increased from about 300 mg/L (milligrams per liter) to more than 1,500 mg/L, and the water changed from primarily a magnesium calcium bicarbonate to primarily a magnesium sulfate type. Monitored water levels in two wells completed in the perched aquifer(s) above the mine indicate that fractures from subsidence- related deformation drained the perched aquifer in the Blackhawk Formation. The deformation also could have contributed to the decrease in discharge of three springs above the mined area, but discharge from other springs in the area did not change ubstantially; thus, the relation between subsidence and spring discharge, if any, is not clear. No significant changes in the chemical character of water discharging from springs were detected, but the dissolved-solids concentration in water collected from a perched sandstone aquifer overlying the mined coal seams increased during mining activity.

  1. Coenzyme Q-responsive Leigh's encephalopathy in two sisters.

    NARCIS (Netherlands)

    Maldergem, L. van; Trijbels, J.M.F.; Mauro, S. Di; Sindelar, P.J.; Musumeci, O.; Janssen, A.J.M.; Delberghe, X.; Martin, J.J.; Gillerot, Y.

    2002-01-01

    A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical

  2. An interesting case of Leigh-like syndrome

    Directory of Open Access Journals (Sweden)

    K Bharani

    2012-01-01

    Full Text Available A 12-year-old female child with motor developmental delay presented with persistent vomiting, recurrent falls and unsteadiness in dark since 2 years of age. There was decline in scholastic performance, bulbar symptoms and aggravation of symptoms during intercurrent illness. Clinically, she had frontal and parietal lobar dysfunction, dysarthria, optic atrophy and LMN VII, IX, X, XII cranial nerve involvement. There was generalized hypotonia, distal muscle wasting, weakness, cerebellar signs and impaired vibration/position sense in distal extremities. Biochemical investigations revealed elevated serum/cerebrospinal fluid (CSF lactate and CSF lactate pyruvate ratio. Neuroimaging demonstrated bilateral symmetrical T2 hyperintensities in basal ganglia, subcortical white matter, cerebellar hemispheres and posterior aspect of spinal cord. As certain atypical features like bilateral symmetrical T2 hyperintensities in subcortical white matter were also seen, metachromatic leukodystrophy was considered in differential diagnosis but ruled out by nerve biopsy. This case is reported for the presence of atypical neuroimaging features that are rarely found in Leigh′s disease.

  3. Japan is far... / Peeter Miller

    Index Scriptorium Estoniae

    Miller, Peeter

    2007-01-01

    Eesti suursaadik Jaapanis Eesti ja Jaapani suhete ajaloost, Jaapani keisri Akihito ja keisrinna Michiko ametlikust visiidist Eestisse 2007. a. mais. Juuresolevatel fotodel president Toomas Hendrik Ilves ja proua Evelin Ilves kõrgeid külalisi vastu võtmas

  4. Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-{kappa}B, p38MAPK and Akt inhibition

    Energy Technology Data Exchange (ETDEWEB)

    Essafi-Benkhadir, Khadija [Laboratoire d' epidemiologie Moleculaire et Pathologie Experimentale Appliquee Aux Maladies Infectieuses, Institut Pasteur de Tunis (Tunisia); Refai, Amira [Laboratoire de Recherche sur la Transmission, le Controle et l' immunobiologie des Infections, Institut Pasteur de Tunis (Tunisia); Riahi, Ichrak [Laboratoire d' epidemiologie Moleculaire et Pathologie Experimentale Appliquee Aux Maladies Infectieuses, Institut Pasteur de Tunis (Tunisia); Fattouch, Sami [Laboratory LIP-MB National Institute of Applied Sciences and Technology, Tunis (Tunisia); Karoui, Habib [Laboratoire d' epidemiologie Moleculaire et Pathologie Experimentale Appliquee Aux Maladies Infectieuses, Institut Pasteur de Tunis (Tunisia); Essafi, Makram, E-mail: makram.essafi@pasteur.rns.tn [Laboratoire de Recherche sur la Transmission, le Controle et l' immunobiologie des Infections, Institut Pasteur de Tunis (Tunisia)

    2012-02-03

    Highlights: Black-Right-Pointing-Pointer Quince peel polyphenols inhibit LPS-induced secretion of TNF-{alpha} and IL-8. Black-Right-Pointing-Pointer Quince peel polyphenols augment LPS-induced secretion of IL-10 and IL-6. Black-Right-Pointing-Pointer Quince peel polyphenols-mediated inhibition of LPS-induced secretion of TNF-{alpha} is partially mediated by IL-6. Black-Right-Pointing-Pointer The anti-inflammatory effects of quince polyphenols pass through NF-{kappa}B, p38MAPK and Akt inhibition. -- Abstract: Chronic inflammation is a hallmark of several pathologies, such as rheumatoid arthritis, gastritis, inflammatory bowel disease, atherosclerosis and cancer. A wide range of anti-inflammatory chemicals have been used to treat such diseases while presenting high toxicity and numerous side effects. Here, we report the anti-inflammatory effect of a non-toxic, cost-effective natural agent, polyphenolic extract from the Tunisian quince Cydonia oblonga Miller. Lipopolysaccharide (LPS) treatment of human THP-1-derived macrophages induced the secretion of high levels of the pro-inflammatory cytokine TNF-{alpha} and the chemokine IL-8, which was inhibited by quince peel polyphenolic extract in a dose-dependent manner. Concomitantly, quince polyphenols enhanced the level of the anti-inflammatory cytokine IL-10 secreted by LPS-treated macrophages. We further demonstrated that the unexpected increase in IL-6 secretion that occurred when quince polyphenols were associated with LPS treatment was partially responsible for the polyphenols-mediated inhibition of TNF-{alpha} secretion. Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-{kappa}B), p38MAPK and Akt. Overall, our data indicate that quince peel polyphenolic extract induces a potent anti-inflammatory effect that may prove useful for the treatment of inflammatory diseases and that a quince

  5. Revisió taxonòmica del gènere Chamaemelum Miller (Asteraceae) a la Península Ibèrica i les Illes Balears

    OpenAIRE

    Benedí, Carles

    1987-01-01

    Se realiza una revisión taxonómica del género Chamaemelum Miller (Asteraceae) en la Península Ibérica e Islas Baleares. Se proponen dos cambios nomenclaturales: Chamaemelum nobile(L.) All. forma discoideum (Willk.) comb. i stat. nov. y C. fuscatum (Brot.) Vasc. forma minor (Hoffmanns. i Link) comb. i stat. nov. Para cada taxon se da el nombre correcto, así como las correspondientes sinonimias. Se adjunta una clave dicotómica de los táxones reconocidos y una relación de los testimonios de herb...

  6. The Miller Range 090340 and 090206 meteorites: Identification of new brachinite-like achondrites with implications for the diversity and petrogenesis of the brachinite clan

    Energy Technology Data Exchange (ETDEWEB)

    Goodrich, Cyrena Anne [Lunar and Planetary Institute, 3600 Bay Area Blvd Houston Texas 77058 USA; Planetary Science Institute, 1700 E. Ft. Lowell Drive Tucson Arizona 85719 USA; Kita, Noriko T. [Wisc-SIMS, University of Wisconsin, Madison Wisconsin 53706 USA; Sutton, Stephen R. [Department of Geophysical Sciences, University of Chicago, Chicago Illinois 60637 USA; Center for Advanced Radiation Sources, University of Chicago, Chicago Illinois 60637 USA; Wirick, Sue [Center for Advanced Radiation Sources, University of Chicago, Chicago Illinois 60637 USA; Gross, Juliane [Department of Earth and Planetary Sciences, Rutgers University, 610 Taylor Rd Piscataway New Jersey 08854 USA; Department of Earth and Planetary Sciences, The American Museum of Natural History, New York New York 10024 USA

    2017-05-01

    Miller Range (MIL) 090340 and MIL 090206 are olivine-rich achondrites originally classified as ureilites. We investigate their petrography, mineral compositions, olivine Cr valences, equilibration temperatures, and (for MIL 090340) oxygen isotope compositions, and compare them with ureilites and other olivine-rich achondrites. We conclude that they are brachinite-like achondrites that provide new insights into the petrogenesis of brachinite clan meteorites. MIL 090340,6 has a granoblastic texture and consists of ~97 modal % by area olivine (Fo = molar Mg/[Mg+Fe] = 71.3 ± 0.6). It also contains minor to trace augite, chromite, chlorapatite, orthopyroxene, metal, troilite, and terrestrial Fe-oxides. Approximately 80% by area of MIL 090206,5 has a granoblastic texture of olivine (Fo 72.3 ± 0.1) plus minor augite and chromite, similar to MIL 090340 but also containing minor plagioclase. The rest of the section consists of a single crystal of orthopyroxene (~11 × 3 mm), poikilitically enclosing rounded grains of olivine (Fo = 76.1 ± 0.6), augite, chromite, metal, and sulfide. Equilibration temperatures for MIL 090340 and MIL 090206, calculated from olivine-spinel, olivine-augite, and two-pyroxene thermometry range from ~800 to 930 °C. In both samples, symplectic intergrowths of Ca-poor orthopyroxene + opaque phases (Fe-oxides, sulfide, metal) occur as rims on and veins/patches within olivine. Before terrestrial weathering, the opaques were probably mostly sulfide, with minor metal. All petrologic properties of MIL 090340 and MIL 090206 are consistent with those of brachinite clan meteorites, and largely distinct from those of ureilites. Oxygen isotope compositions of olivine in MIL 090340 (δ18O = 5.08 ± 0.30‰, δ17O = 2.44 ± 0.21%, and Δ17O = -0.20 ± 0.12‰) are also within the range of brachinite clan meteorites, and well distinguished from ureilites. Olivine Cr valences in MIL 090340 and the granoblastic area of MIL 090206 are 2.57 ± 0.06 and 2.59 ± 0

  7. The Miller Range 090340 and 090206 meteorites: Identification of new brachinite-like achondrites with implications for the diversity and petrogenesis of the brachinite clan

    Science.gov (United States)

    Goodrich, Cyrena Anne; Kita, Noriko T.; Sutton, Stephen R.; Wirick, Sue; Gross, Juliane

    2017-05-01

    Miller Range (MIL) 090340 and MIL 090206 are olivine-rich achondrites originally classified as ureilites. We investigate their petrography, mineral compositions, olivine Cr valences, equilibration temperatures, and (for MIL 090340) oxygen isotope compositions, and compare them with ureilites and other olivine-rich achondrites. We conclude that they are brachinite-like achondrites that provide new insights into the petrogenesis of brachinite clan meteorites. MIL 090340,6 has a granoblastic texture and consists of 97 modal % by area olivine (Fo = molar Mg/[Mg+Fe] = 71.3 ± 0.6). It also contains minor to trace augite, chromite, chlorapatite, orthopyroxene, metal, troilite, and terrestrial Fe-oxides. Approximately 80% by area of MIL 090206,5 has a granoblastic texture of olivine (Fo 72.3 ± 0.1) plus minor augite and chromite, similar to MIL 090340 but also containing minor plagioclase. The rest of the section consists of a single crystal of orthopyroxene ( 11 × 3 mm), poikilitically enclosing rounded grains of olivine (Fo = 76.1 ± 0.6), augite, chromite, metal, and sulfide. Equilibration temperatures for MIL 090340 and MIL 090206, calculated from olivine-spinel, olivine-augite, and two-pyroxene thermometry range from 800 to 930 °C. In both samples, symplectic intergrowths of Ca-poor orthopyroxene + opaque phases (Fe-oxides, sulfide, metal) occur as rims on and veins/patches within olivine. Before terrestrial weathering, the opaques were probably mostly sulfide, with minor metal. All petrologic properties of MIL 090340 and MIL 090206 are consistent with those of brachinite clan meteorites, and largely distinct from those of ureilites. Oxygen isotope compositions of olivine in MIL 090340 (δ18O = 5.08 ± 0.30‰, δ17O = 2.44 ± 0.21‰, and Δ17O = -0.20 ± 0.12‰) are also within the range of brachinite clan meteorites, and well distinguished from ureilites. Olivine Cr valences in MIL 090340 and the granoblastic area of MIL 090206 are 2.57 ± 0.06 and 2.59 ± 0

  8. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from NOAA Ship MILLER FREEMAN in the Bering Sea, Coastal Waters of SE Alaska and others from 2009-05-16 to 2010-10-08 (NODC Accession 0117502)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0117502 includes Surface underway, chemical, meteorological and physical data collected from NOAA Ship MILLER FREEMAN in the Bering Sea, Coastal...

  9. The use of Gamma radiation of Cobalt-60 to control avocado moth Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) and its effects on the quality of the fruit of Persea americana (Miller) (Lauraceae).; Uso da radiacao gama do Cobalto-60, para controlar a broca-do-abacate Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) e seus efeitos na qualidade do fruto de Persea americana (Miller) (Lauraceae)

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Lilian Karla Figueira da

    2004-07-01

    This work aimed to evaluate the influence of Gamma radiation of Cobalt-60, in the avocado moth Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) and its effects on the quality of the fruit Persea americana (Miller) (Lauraceae). For this research, insects were irradiated in ali phases of their life cycle with doses varying from O to 600 Gy and they were maintained at the temperature of 25 +- 2 deg C, humidity of 70 +- 10% and photo phase of 14 h. The species was raised on natural diet, avocado seeds. The cultivar fruits Geada were irradiated with doses that varied from 0 to 150 Gy, maintained for 15 days at room temperature (20 a 35 deg C and humidity of 70 - 80 %) and 30 days at a temperature of 10 deg C, humidity of 40 - 60 %. The chemical-physics and sensorial analyses were carried out. According to the obtained results, it was verified that the lethal dose of gamma radiation to S. catenifer eggs, was of 75 Gy; for caterpillars and pupas was of 300 Gy. The sterile-dose for upcoming adults from irradiated S. catenifer eggs was of 25 Gy; for upcoming adults from irradiated caterpillars, it was of 100 Gy; for adults coming from irradiated pupas was of 150 Gy and for irradiated adults was of 200 Gy. The irradiation in the avocado fruit, maintained at room temperature for 7 days of storage, caused change in the coloration of the fruit (dark spots and yellowish coloration) and more firmness. The sensorial characteristics were kept and the irradiated fruit was the chosen one as favorite for tasting. The irradiated fruits that were kept at 10 deg C, obtained an increase in the storage period, without changing their chemical physics characteristics. The coloration of the fruits was kept, more firmness and a subtle acidity taste increase, being effective in the conservation of the fruits and in the maintenance of their sensorial characteristics. The use of the gamma radiation as treatment quarantine of S. catenifer it was efficient, should be treated them with

  10. 3 February 2011 - British Members of the Science and Technology Committee (Commons)led by A. Miller MP signing the guest book with CERN Director for Accelerators and Technology S. Myers; in the ATLAS experimental cavern at LHC Point 1 with Spokesperson F. Gianotti and Deputy D. Charlton.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    3 February 2011 - British Members of the Science and Technology Committee (Commons)led by A. Miller MP signing the guest book with CERN Director for Accelerators and Technology S. Myers; in the ATLAS experimental cavern at LHC Point 1 with Spokesperson F. Gianotti and Deputy D. Charlton.

  11. Effect of drug load and plate coating on the particle size distribution of a commercial albuterol metered dose inhaler (MDI) determined using the Andersen and Marple-Miller cascade impactors.

    Science.gov (United States)

    Nasr, M M; Ross, D L; Miller, N C

    1997-10-01

    The purpose of this study is to investigate the effect of drug load, the coating of impactor stages, and the design of cascade impactors on albuterol MDIs particle size distribution measurements. The results of the investigation will be used to explain the "loading effect" recently reported. Particle size distribution parameters of a commercial albuterol MDI were measured using both Andersen (AI) and Marple-Miller (MMI) Cascade Impactors, where plates were either left uncoated or coated with silicone or glycerin. A previously validated HPLC-EC method was used for the assay of albuterol collected by the impactor and in single spray content determinations. Coating impactor collection plates had an impact on measured MMAD and GSD values for single puff measurements but very little or no effect for the multi puff measurements. Due to particle bounce, the percent of albuterol fine particles deposited in the filter and impactor finer stages (coated single puff or multi-puff (coated and uncoated) measurements. Evaluation of drug load and plate coating are necessary to determine whether observed particle size distributions are representative of the generated aerosol or are the result of particle bounce and reentrainment. In order to minimize particle bounce, especially for single puff determinations, it may be useful to apply a thin layer of a sticky coating agent to the surfaces of impactor plates.

  12. Multi-responses extraction optimization combined with high-performance liquid chromatography-diode array detection-electrospray ionization-tandem mass spectrometry and chemometrics techniques for the fingerprint analysis of Aloe barbadensis Miller.

    Science.gov (United States)

    Zhong, Jia-Sheng; Wan, Jin-Zhi; Ding, Wen-Jing; Wu, Xiao-Fang; Xie, Zhi-Yong

    2015-03-25

    A quality control strategy using high-performance liquid chromatography-diode array detector-electrospray ionization-tandem mass spectrometry (HPLC-DAD-ESI-MS/MS) coupled with chemometrics analysis was proposed for Aloe barbadensis Miller. Firstly, the extraction conditions including methanol concentration, extraction time and solvent-to-material ratio were optimized by multi-responses optimization based on response surface methodology (RSM). The optimum conditions were achieved by Derringer's desirability function and experimental validation implied that the established model exhibited favorable prediction ability. Then, HPLC fingerprint consisting of 27 common peaks was developed among 15 batches of A. barbadensis samples. 25 common peaks were identified using HPLC-DAD-ESI-MS/MS method by their spectral characteristics or comparison with the authentic standards. Chemometrics techniques including similarity analysis (SA), principal components analysis (PCA) and hierarchical clustering analysis (HCA) were implemented to classify A. barbadensis samples. The results demonstrated that all A. barbadensis samples shared similar chromatographic patterns as well as differences. These achievements provided an effective, reliable and comprehensive quality control method for A. barbadensis. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Quadratic Sagnac effect — the influence of the gravitational potential of the Coriolis force on the phase difference between the arms of a rotating Michelson interferometer (an explanation of D C Miller's experimental results, 1921 – 1926)

    International Nuclear Information System (INIS)

    Malykin, G B; Pozdnyakova, V I

    2015-01-01

    It is shown that when an equal-arm Michelson interferometer is involved in rotation (for example, Earth's rotation around its axis or around the Sun) and its arms are oriented differently with respect to the plane of rotation, a phase difference arises between the light rays that pass through different arms. This phase difference is due to the fact that the arms experience variously the Newtonian (nonrelativistic) scalar gravitational potential of the Coriolis forces. It is shown that the phase difference is proportional to the length of the interferometer arm, the square of the angular velocity of the rotation, and the square of the distance from the center of rotation — hence, the proposal to call this phenomenon the quadratic Sagnac effect. In the present paper, we consider, as an illustrative example, the results of the once well-known experiments of D C Miller, who claimed to observe the translational motion of Earth relative to the hypothetical ‘luminiferous ether’. It is shown that this claim can actually be explained by the fact that, because of the orbital revolution of Earth, the time dilations in the orthogonal arms of the Michelson interferometer are influenced differently by the scalar gravitational potential of the Coriolis forces. (methodological notes)

  14. Supplement to the paper 'Quadratic Sagnac effect — the influence of the gravitational potential of the Coriolis force on the phase difference between the arms of a rotating Michelson interferometer (an explanation of D C Miller's experimental results, 1921 – 1926)' (Usp. Fiz. Nauk185 431 (2015) [Phys. Usp.58 398 (2015)])

    International Nuclear Information System (INIS)

    Malykin, G B; Pozdnyakova, V I

    2015-01-01

    The paper 'Quadratic Sagnac effect — the influence of the gravitational potential of the Coriolis force on the phase difference between the arms of a rotating Michelson interferometer (an explanation of D C Miller's experimental results, 1921 – 1926)' (Usp. Fiz. Nauk 185 431 (2015) [Phys. Usp. 58 398 (2015)]) is amended and supplemented with information concerning earlier work on the influence of rotation on Michelson – Morley's nonzero results. (letters to the editors)

  15. Unexpected 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]quinolines from Skraup-Doebner-Von Miller quinoline synthesis and their implications for the mechanism of that reaction.

    Science.gov (United States)

    Fotie, Jean; Kemami Wangun, Hilaire V; Fronczek, Frank R; Massawe, Nancy; Bhattarai, Bijay T; Rhodus, Jessica L; Singleton, Thomas A; Bohle, D Scott

    2012-03-16

    The real mechanism of the Skraup-Doebner-Von Miller quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]quinolines have been obtained through the Skraup-Doebner-Von Miller quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the quinoline ring, leading to a dihydroquinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup-Doebner-Von Miller quinoline synthesis.

  16. Organik ve Konvansiyonel Yağ Gülü Rosa damascena Miller (Rosales: Rosaceae Yetiştiriciliğinde Böcek Biyolojik Çeşitlilik Değerlerinin Hesaplanması

    Directory of Open Access Journals (Sweden)

    Özlem DİNÇ ORTAÇ

    2015-09-01

    Full Text Available The aim of the study is comparison of diversity, population density and similarity index of insects living in Rosa damascena Miller (Rosales: Rosaceae (oil rose gardens managed by rules of organic and conventional farming chosen in Isparta province, Keçiborlu County, Ardıçlı village during 2012. Pitfall traps, knockdown, sweeping and counting with eyes sampling methods were used for sampling of the insect species between April and October where the insect species population density could be found the highest and taken rates of species from pitfall traps compared for statistically significant between organic and conventional oil rose gardens. Finally both agro-ecosystems no pesticide application were used and managed by the rules of organic farming were found different results of insect bio-diversity then another two agro-ecosystems pesticide application were used and managed by the rules of the conventional faming. Shannon-Wiener and Simpson diversity index were found lower in both conventional rose gardens than other 2 organic rose agro-ecosystems while Shannon-evenness were found more stable in organic rose gardens than conventional ones. The data obtained by pitfall traps have given a more precise than the other sampling methods and according to evaluation of pitfall trap, similarity index of two agro-ecosystems managed by conventional farming rules were found 72.38% to each other and these habitats were found the most similar habitats. Besides, sampled insect species belonging to Carabidae, Scarabaeidae, and Tenebrionidae families were declared the first time with this study

  17. Ideal of millers and bakers: 'Sofija'

    Directory of Open Access Journals (Sweden)

    Denčić Srbislav

    2000-01-01

    Full Text Available The winter wheat cultivar Sofija was developed by crossing varieties ZG 965/76 and Panonija. The semi-dwarf stature, good yield ability, very good resistance to low temperatures, lodging and prevalent disease are the main agronomic characteristics of the cultivar. The most importance and valuable character of cv Sofija is it's bread-making quality. According to preliminary long term data the cultivar possess high protein content (> 14%, sedimentation value (> 50, wet gluten (> 35, crumb number (> 6, etc. Regarding to bread-making parameters cv. Sofija is on the level or even better than cv. Partizanka, while yield capacity is on the level of high yielded domestic wheat cultivars Evropa 90 and Pobeda. .

  18. Terry Miller : Eesti on majandusvabaduse maailmas kangelane

    Index Scriptorium Estoniae

    2008-01-01

    Majanduskonverentsil Restart esinenud pikaajalise kogemusega karjääridiplomaadi Terry Milleri hinnang Eesti majandusvabadusele. Eesti on maailma majandusvabaduse indeksi 12. kohal, kuid tööturu vabaduse osas on Eesti viimaste hulgas. Lisa: Majandusvabadus suurendab rahvuslikku rikkust

  19. Liiga palju raha / Karen Lowry Miller

    Index Scriptorium Estoniae

    Miller, Karen Lowry

    2003-01-01

    Ilmunud ka: Spekter (vene k.) nr. 2, lk. 20-23. Autor kirjeldab, kuidas investorid rahanappusest üleküllusesse sattunud maailmas pidevalt uusi investeerimisvõimalusi otsivad ja juhib tähelepanu investorite poolt tekitatud majandusbuumides peituvatele ohtudele. Kaart: Seebimullide maakaart. Diagrammid: Raha kasvab kiiremini; Ülemaailmselt liikuv kapital

  20. Genetics Home Reference: Miller-Dieker syndrome

    Science.gov (United States)

    ... Support and Advocacy Resources (2 links) Brain Foundation (Australia) National Organization for Rare Disorders (NORD): Lissencephaly GeneReviews ( ... Pizzardi G, Del Balzo F, Iannetti P. Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. Acta Paediatr. ...

  1. Evidence from Ethiopian Grain Traders and Millers

    African Journals Online (AJOL)

    Daniel

    According to Dessalegn et.al. (1997), limited access to finance was identified as one of the major constraints of grain marketing in Ethiopia. Traders who did not obtain loan from banks identified lack of collateral, high risk in grain trade and high competition from unlicensed traders as the main reasons constraining access to ...

  2. FLOODPLAIN, MILLER COUNTY, GA AND INCORPORATED AREAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — he Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  3. What is Metaphysical Equivalence? | Miller | Philosophical Papers

    African Journals Online (AJOL)

    Theories are metaphysically equivalent just if there is no fact of the matter that could render one theory true and the other false. In this paper I argue that if we are judiciously to resolve disputes about whether theories are equivalent or not, we need to develop testable criteria that will give us epistemic access to the obtaining ...

  4. [Miller Fisher's syndrome. Clinical and experimental contribution].

    Science.gov (United States)

    Trebini, F; Appiotti, A; Scarzella, G

    1991-01-01

    A 19-year-old patient with acute idiopathic polyneuritis is described. Clinically, apart from ophthalmoplegia, areflexia and ataxia, the patient presented a serious bilateral and symmetrical deficiency of the VII-IX-X cranial nerve and hypanapallesthesia of trunk and extremities. Liquor examination showed albumino-cytological dissociation with an increase in liquor IgG; encephalic CT and encephalo-medullary NMR were normal; a neurophysiological study (EMG, PEV, BAER) was indicative of the PNS problems. Combined corticosteroid and plasmaferesis treatment produced complete clinical remission after about 3 months. The primary role of PNS involvement in this clinical entity is discussed.

  5. David Miller on Immigration Policy and Nationality

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2007-01-01

    as determinative of the scope of distributive justice and as giving rise to national collective responsibility. Three interpretations of his main positive reason for restricting immigration, which concerns the importance of a shared public culture, are then discussed: culture as having valuable social functions...... in relation to immigration policy....

  6. The use of Gamma radiation of Cobalt-60 to control avocado moth Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) and its effects on the quality of the fruit of Persea americana (Miller) (Lauraceae)

    International Nuclear Information System (INIS)

    Silva, Lilian Karla Figueira da

    2004-01-01

    This work aimed to evaluate the influence of Gamma radiation of Cobalt-60, in the avocado moth Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) and its effects on the quality of the fruit Persea americana (Miller) (Lauraceae). For this research, insects were irradiated in ali phases of their life cycle with doses varying from O to 600 Gy and they were maintained at the temperature of 25 +- 2 deg C, humidity of 70 +- 10% and photo phase of 14 h. The species was raised on natural diet, avocado seeds. The cultivar fruits Geada were irradiated with doses that varied from 0 to 150 Gy, maintained for 15 days at room temperature (20 a 35 deg C and humidity of 70 - 80 %) and 30 days at a temperature of 10 deg C, humidity of 40 - 60 %. The chemical-physics and sensorial analyses were carried out. According to the obtained results, it was verified that the lethal dose of gamma radiation to S. catenifer eggs, was of 75 Gy; for caterpillars and pupas was of 300 Gy. The sterile-dose for upcoming adults from irradiated S. catenifer eggs was of 25 Gy; for upcoming adults from irradiated caterpillars, it was of 100 Gy; for adults coming from irradiated pupas was of 150 Gy and for irradiated adults was of 200 Gy. The irradiation in the avocado fruit, maintained at room temperature for 7 days of storage, caused change in the coloration of the fruit (dark spots and yellowish coloration) and more firmness. The sensorial characteristics were kept and the irradiated fruit was the chosen one as favorite for tasting. The irradiated fruits that were kept at 10 deg C, obtained an increase in the storage period, without changing their chemical physics characteristics. The coloration of the fruits was kept, more firmness and a subtle acidity taste increase, being effective in the conservation of the fruits and in the maintenance of their sensorial characteristics. The use of the gamma radiation as treatment quarantine of S. catenifer it was efficient, should be treated them with

  7. Toxicology and carcinogenesis studies of a nondecolorized [corrected] whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study).

    Science.gov (United States)

    Boudreau, M D; Beland, F A; Nichols, J A; Pogribna, M

    2013-08-01

    Extracts from the leaves of the Aloe vera plant (Aloe barbadensis Miller) have long been used as herbal remedies and are also now promoted as a dietary supplement, in liquid tonics, powders or tablets, as a laxative and to prevent a variety of illnesses. We studied the effects of Aloe vera extract on rats and mice to identify potential toxic or cancer-related hazards. We gave solutions of nondecolorized extracts of Aloe vera leaves in the drinking water to groups of rats and mice for 2 years. Groups of 48 rats received solutions containing 0.5%, 1% or 1.5% of Aloe vera extract in the drinking water, and groups of mice received solutions containing 1%, 2%, or 3% of Aloe vera extract. Similar groups of animals were given plain drinking water and served as the control groups. At the end of the study tissues from more than 40 sites were examined for every animal. In all groups of rats and mice receiving the Aloe vera extract, the rates of hyperplasia in the large intestine were markedly increased compared to the control animals. There were also increases in hyperplasia in the small intestine in rats receiving the Aloe vera extract, increases in hyperplasia of the stomach in male and female rats and female mice receiving the Aloe vera extract, and increases in hyperplasia of the mesenteric lymph nodes in male and female rats and male mice receiving the Aloe vera extract. In addition, cancers of the large intestine occurred in male and female rats given the Aloe vera extract, though none had been seen in the control groups of rats for this and other studies at this laboratory. We conclude that nondecolorized Aloe vera caused cancers of the large intestine in male and female rats and also caused hyperplasia of the large intestine, small intestine, stomach, and lymph nodes in male and female rats. Aloe vera extract also caused hyperplasia of the large intestine in male and female mice and hyperplasia of the mesenteric lymph node in male mice and hyperplasia of the stomach

  8. Alex Miller, Knesseti liige : Iisrael mõtleb oma kodanikele / Alex Miller ; interv. Ivar Soopan

    Index Scriptorium Estoniae

    Miller, Alex

    2007-01-01

    Iisraeli parlamendiliikme sõnul ei ole läbirääkimised Palestiinaga vastuvõetavad, kui valitsuses on Hamas. Iisraeli-Palestiina konflikt ei ole tema sõnul mitte territoriaalprobleem, vaid tsivilisatsioonidevaheline konflikt. Parlamendiliige vastab küsimustele, mis puudutavad Palestiinale kuuluva 600 miljoni dollari maksuraha kinnihoidmist ning 40 Palestiina parlamendiliikme vangistamist, samuti Liibanoni ründamist eelmisel aastal

  9. VizieR Online Data Catalog: IRTF J-band spectrum of Mrk 231 (Leighly+, 2014)

    Science.gov (United States)

    Leighly, K. M.; Terndrup, D. M.; Baron, E.; Lucy, A. B.; Dietrich, M.; Gallagher, S. C.

    2017-07-01

    Mrk 231 was observed using SpeX (Rayner et al. 2003PASP..115..362R) on the NASA Infrared Telescope Facility (IRTF) on 2010 April 24 for 30 minutes. A standard ABBA integration scheme was used. The A0 star HD 112623 was used for flux and telluric corrections. The spectra were reduced, and the telluric correction applied, in the standard manner using Spextool and accompanying software (Cushing et al. 2004PASP..116..362C; Vacca et al. 2003PASP..115..389V). The resolution measured from the arc lamp lines was about 12 Å FWHM, or 330 km/s in the vicinity of the absorption line. The galactic reddening in the direction of Mrk 231 is E(B-V)=0.0095, and we corrected for that using the CCM reddening curve (Cardelli et al. 1988ApJ...329L..33C). (1 data file).

  10. Witch-hunts, Theocracies and Hypocrisy: McCarthyism in Arthur Miller/ Robert Ward’s opera The Crucible and Carlisle Floyd’s Susannah Chasse aux sorcières, théocratie et hypocrisie : Le McCarthysme dans Susannah de Carlisle Floyd et The Crucible de Robert Ward

    Directory of Open Access Journals (Sweden)

    Rachel Hutchins-Viroux

    2009-08-01

    Full Text Available Le répertoire d’opéras américains comporte deux œuvres qui furent créées afin de dénoncer le maccarthysme : Susannah, de Carlisle Floyd, et The Crucible de Robert Ward, d’après la pièce d’Arthur Miller. Ces deux œuvres sont des paraboles qui critiquent la chasse aux sorcières anti-communiste des années 1950 à travers des mythes plus anciens. Susannah s’inspire de l’histoire biblique de Suzanne et les Vieillards, déplaçant l’action pour la resituer au sud des États-Unis au vingtième siècle, et The Crucible s’appuie sur l’histoire américaine (des événements qui sont mythifiés en tant qu’éléments de la conscience nationale : les procès des « sorcières » de Salem. Ces œuvres dramatiques transposent les histoires plus anciennes en nouveaux mythes qui communiquent des aspects négatifs et tragiques du caractère et de l’expérience américains.

  11. Public access to private land in Scotland | Miller | Potchefstroom ...

    African Journals Online (AJOL)

    The essential point is that Scots common law does not give civil damages for a simple act of trespass (as English law does) but only a right to obtain removal of the trespasser. Under the reforms the longstanding Scottish position of landowners allowing walkers access to the hills and mountains becomes a legal right.

  12. Majandusvabadus - kas jätkuvalt lahendus / Terry Miller

    Index Scriptorium Estoniae

    Miller, Terry

    2009-01-01

    Artikkel keskendub põgusalt tulevikus maailma ees ootavale kliimamuutustest tulenevale majanduskriisile, riigipoolsete eraettevõtlusesse sekkumiste mõjule majanduskriisi ületamisel ning majandusvabaduse indeksile

  13. Infertility | Jose-Miller | South African Family Practice

    African Journals Online (AJOL)

    Infertility is defined as failure to achieve pregnancy during one year of frequent, unprotected intercourse. Evaluation generally begins after 12 months, but it can be initiated earlier if infertility is suspected based on history or if the female partner is older than 35 years. Major causes of infertility include male factors, ovarian ...

  14. Optical computing, optical memory, and SBIRs at Foster-Miller

    Science.gov (United States)

    Domash, Lawrence H.

    1994-03-01

    A desktop design and manufacturing system for binary diffractive elements, MacBEEP, was developed with the optical researcher in mind. Optical processing systems for specialized tasks such as cellular automation computation and fractal measurement were constructed. A new family of switchable holograms has enabled several applications for control of laser beams in optical memories. New spatial light modulators and optical logic elements have been demonstrated based on a more manufacturable semiconductor technology. Novel synthetic and polymeric nonlinear materials for optical storage are under development in an integrated memory architecture. SBIR programs enable creative contributions from smaller companies, both product oriented and technology oriented, and support advances that might not otherwise be developed.

  15. Editorial | Miller | Southern African Journal of Critical Care

    African Journals Online (AJOL)

    Southern African Journal of Critical Care. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 33, No 2 (2017) >. Log in or Register to get access to full text downloads.

  16. Public access to private land in Scotland | Miller | Potchefstroom ...

    African Journals Online (AJOL)

    Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 15, No 2 (2012) >. Log in or Register to get access to full text downloads.

  17. Public access to private land in Scotland | Miller | Potchefstroom ...

    African Journals Online (AJOL)

    This article attempts to understand the radical reform of Scottish land law in its provision for a general right of public access to private land introduced in 2003 as part of land reform legislation, an important aspect of the initial agenda of the Scottish Parliament revived in 1999. The right is to recreational access for a limited ...

  18. Antioxidant Effect of Lippia alba (Miller N. E. Brown

    Directory of Open Access Journals (Sweden)

    Claire E. Chies

    2013-09-01

    Full Text Available Lippia alba is a shrub found in all regions of Brazil and other countries in South and Central America. L. alba exhibits variability among its different accessions, showing differences in morphology and in the composition of its essential oil. This study evaluated the phenolic profiles and the antioxidant activities of seven different accessions of L. alba. The seven accessions of L. alba studied exhibited an important phenolic content, and all accessions demonstrated antioxidant activity with different efficacies. The main flavonoids in all accessions were apigenin, luteolin, naringin and rutin. The Santa Vitória do Palmar accession exhibited higher naringin and total phenolic content. This extract was able to reduce hydrogen peroxide-induced oxidative damage in tissue homogenates of cerebellum, cerebral cortex, hippocampus and liver of Wistar rats.

  19. Simon Shaw-Miller and Sam Smiles, Samuel Palmer Revisited

    OpenAIRE

    Adrien, Muriel

    2013-01-01

    This edited volume, which compiles chapters by leading historians and curators, aims at revising various clichés of Palmer’s life and at reinstating Samuel Palmer (1805-1881) in the artistic context of his time, despite his legendary outsider status, and although his idiosyncrasies indeed repeatedly put him at odds with the dominant taste of his time. In a very useful introduction, William Vaughan gives a panoramic overview of the critical reception of Palmer’s work throughout history, and of...

  20. Antioxidant Effect of Lippia alba (Miller) N. E. Brown

    OpenAIRE

    Chies, Claire E.; Branco, C?tia S.; Scola, Gustavo; Agostini, Fabiana; Gower, Adriana E.; Salvador, Mirian

    2013-01-01

    Lippia alba is a shrub found in all regions of Brazil and other countries in South and Central America. L. alba exhibits variability among its different accessions, showing differences in morphology and in the composition of its essential oil. This study evaluated the phenolic profiles and the antioxidant activities of seven different accessions of L. alba. The seven accessions of L. alba studied exhibited an important phenolic content, and all accessions demonstrated antioxidant activity wit...

  1. Antioxidant Effect of Lippia alba (Miller) N. E. Brown

    Science.gov (United States)

    Chies, Claire E.; Branco, Cátia S.; Scola, Gustavo; Agostini, Fabiana; Gower, Adriana E.; Salvador, Mirian

    2013-01-01

    Lippia alba is a shrub found in all regions of Brazil and other countries in South and Central America. L. alba exhibits variability among its different accessions, showing differences in morphology and in the composition of its essential oil. This study evaluated the phenolic profiles and the antioxidant activities of seven different accessions of L. alba. The seven accessions of L. alba studied exhibited an important phenolic content, and all accessions demonstrated antioxidant activity with different efficacies. The main flavonoids in all accessions were apigenin, luteolin, naringin and rutin. The Santa Vitória do Palmar accession exhibited higher naringin and total phenolic content. This extract was able to reduce hydrogen peroxide-induced oxidative damage in tissue homogenates of cerebellum, cerebral cortex, hippocampus and liver of Wistar rats. PMID:26784458

  2. Kaplanid arestimajadesse rahusaadikuks / Igor Miller ; interv. Lauri Leet

    Index Scriptorium Estoniae

    Miller, Igor

    2005-01-01

    Justiitsministeeriumi vanglate osakonna nõunik-peakaplan kinnipeetavate usulisest teenindamisest, Eesti kinnipidamisasutusi teenindavate kaplanite konfessioonist, kaplanitöö erinevustest vanglates ja arestimajades, kaplaniteenuse vabatahtlikkusest, kaplanite ja politsei koostöö mõjust reapolitseiniku tööle. Kommenteerib Põhja Politseiprefektuuri arestimaja komissar Karla Kilk

  3. Hypoxylon terricola Miller a new species for Poland

    Directory of Open Access Journals (Sweden)

    Wanda Truszkowska

    2014-08-01

    Full Text Available Hypoxylon terricola Milter, known from a single collection in Michigan in USA and three sites in Southern France, has been found in Poland; isolated from the soil under Dactylis glomerata L. culture and from the dishwater of the roots of D. glomerata L. groving in the vicinity of the spruce (Picea abies (L. K a r s t mountainers forest.

  4. Actividade antimicrobiana do óleo essencial do Foeniculum vulgare Miller Antimicrobial activity of Foeniculum vulgare Miller essential oil

    Directory of Open Access Journals (Sweden)

    M. T. Tinoco

    2007-01-01

    Full Text Available O Foeniculum vulgare Mill. subsp. vulgare é uma planta espontânea da região mediterrânea, pertencente à família Apiaceae. O seu óleo essencial, principalmente o dos frutos secos, é amplamente utilizado nas indústrias alimentar, farmacêutica, cosmética e perfumaria. Neste trabalho, pretendeu-se avaliar a actividade antimicrobiana do óleo essencial dos frutos verdes e das folhas da variedade de funcho doce colhido no Alentejo, na região de Évora, e relacionar essa actividade com a respectiva composição química. A extracção dos óleos essenciais foi efectuada por hidrodestilação e a sua análise foi feita por GC-FID e GC-MS. No óleo das folhas foram identificados como componentes maioritários os fenilpropanóides anetol, fenchona e estragol e o monoterpeno a-felandreno, enquanto que o óleo dos frutos apresentou como constituintes predominantes anetol e fenchona. A actividade antimicrobiana dos óleos foi avaliada face às estirpes Staphylococcus aureus, Escherichia coli, Saccharomyces spp., Fusarium oxysporum e Penicillium sp.. Os óleos essenciais apresentaram actividade antimicrobiana contra S. aureus, Saccharomyces spp. e Fusarium oxysporum.Foeniculum vulgare Mill. ssp. vulgare is a spontaneous plant of Mediterranean region that belongs to the Apiaceae family. Its essential oil is used as additives in food, pharmaceutical, cosmetic and perfume industries mainly that one obtained from dried seeds. The main goal of this work were to evaluate the antimicrobial activity of essential oils obtained from fresh leaves and unripe seeds of sweet fennel, collected in Évora-Alentejo, in face of their chemical composition. The extraction of the essentials oils was made by hydrodistillation. Chemical analyses were carried out by GC-FID and GCMS. Phenylpropanoides anethole, fenchone, estragole and the monoterpene aphellandrene were the most abundant compounds of leaves essential oil. Seeds essential oil showed as main components anethole and fenchone. Antimicrobial activities were tested against the strains Staphylococcus aureus, Escherichia coli, Saccharomyces spp., Fusarium oxysporum and Penicillium sp.. Seed and leaves essential oils showed antimicrobial activity against S. aureus Saccharomyces spp. and Fusarium oxysporum.

  5. 75 FR 8330 - Miller and Miller; Notice of Termination of License by Implied Surrender and Soliciting Comments...

    Science.gov (United States)

    2010-02-24

    ... Worthville Dam Project is located on the Deep River in Randolph County, North Carolina. f. Filed Pursuant to... electronically via the Internet in lieu of paper; see 18 CFR 385.2001(a)(1)(iii) and the instructions on the... Internet in lieu of paper; See 18 CFR 385.2001(a)(1)(iii) and the instructions on the Commission's Web site...

  6. 75 FR 19956 - Miller and Miller, Waterpower LLC; Notice of Application for Transfer of License and Soliciting...

    Science.gov (United States)

    2010-04-16

    ... Worthville Dam Project No. 3156, located on the Deep River in Randolph County, North Carolina. Applicants... filed electronically via the Internet. See 18 CFR 385.2001(a)(1)(iii)(2008) and the instructions on the...

  7. Decreased affinity for oxygen of cytochrome-c oxidase in Leigh syndrome caused by SURF1 mutations

    Czech Academy of Sciences Publication Activity Database

    Pecina, Petr; Gnaiger, E.; Zeman, J.; Pronicka, E.; Houštěk, Josef

    2004-01-01

    Roč. 287, č. 5 (2004), s. C1384-C1388 ISSN 0363-6143 R&D Projects: GA ČR(CZ) GA303/03/0749 Grant - others:CZ-AT(CZ) Kontakt-Aktion 2004/S; GA UK(CZ) 24/2004 Institutional research plan: CEZ:AV0Z5011922 Keywords : oxygen kinetics * mitochondrial disease * SURF1 Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 3.939, year: 2004

  8. Revisión de la aloe vera (Barbadensis Miller en la dermatología actual Revision Of Aloe Vera (Barbadensis Miller In Actual Dermatology

    Directory of Open Access Journals (Sweden)

    GM Ferraro

    2009-12-01

    Full Text Available El Aloe vera es una planta de uso popular en el tratamiento de algunas enfermedades de la piel y de aplicación frecuente en la cosmetología. Forma parte de diversas cremas o geles, siendo usado como antiinflamatorio y reconstituyente del tejido epitelial. Aunque se conocen varios mecanismos de acción e indicaciones clínicas, se debe realizar una revisión de las mismas para su uso, avalados por ensayos controlados para determinar su eficacia real.The Aloe vera is a popular plant used in the treatment of certain skin diseases that has a frequent application in cosmetology. It forms a part of diverse creams or gels, being used as anti-inflammatory and restorative of epithelial tissue. Although there are several mechanisms of action and clinical indications, a review of its use should be done supported by controlled trials to determine its effectiveness.

  9. Valeurs nutritives et toxicité du foenicululm vulgare miller | Lazouni ...

    African Journals Online (AJOL)

    The presence of toxic components coming from the secondary metabolism in particular the coumarins and tanins, made up recognized like inhibiting the digestibility of proteins, influential on the evolution of the ponderal mass of the animal (rat "Wistar"). The saponosides, flavonoïdes, sterols and steroïdes, tanins, coumarins, ...

  10. Carotenoids profile and total polyphenols in fruits of Pereskia aculeata Miller

    Directory of Open Access Journals (Sweden)

    Tânia da Silveira Agostini-Costa

    2012-03-01

    Full Text Available Pereskia aculeata Mill. (Ora-pro-nóbis is a native cactaceae from tropical America, whose leaves have high protein content. In Brazil it is found in all territorial extension between the states of Bahia and Rio Grande do Sul. Most studies have focused on chemical characterization of the leaves of this specie. The objective was to assess the carotenoids profile and the total polyphenols present in the fruits of P. aculeate. Carotenoids were determined by HPLC-PAD (high performance liquid chromatography - photodiode array detector, total polyphenols were determined by Folin-Ciocalteu and vanillin methods. Trans-β-carotene was the main carotenoid, followed by α-carotene, lutein and other minor carotenoids. It was found 64.9 ± 1.1 mg.100g-1 of gallic acid equivalent, 14.8 ± 0.2 mg.100g-1 of catechin equivalent. Carotenoid identification of P. aculeate fruits are presented here by the first time and indicate that these fruits can be researched as source of bioactive substances, especially antioxidant and provitamin A carotenoids.

  11. Regeneration and Agrobacterium-mediated Transformation Studies in Tomato ( Lycopersicon esculentum Miller)

    OpenAIRE

    ÖKTEM, Hüseyin Avni; BÜLBÜL, Yeter; ÖKTEM, Emre; YÜCEL, Meral

    2014-01-01

    An optimized regeneration protocol and a suitable transformation technique is a necessity in obtaining transgenic plants in a given plant species. This work summarizes a simple culture method to obtain rooted plants from leaf pieces of two tomato cul-tivars (ES58 and WC156) within 3-4 months. Here, we also present our preliminary results on transformation experiments carried out with 8-day-old cotyledon explants and Agrobacterium tumefaciensEHA105 strain.

  12. Miller Table Company: A Profit Analysis Case Integrating Managerial Accounting, Microeconomics and Marketing

    Science.gov (United States)

    Miller, Louise

    2014-01-01

    This paper describes a unique integrative business case appropriate for use in a managerial accounting course or other business courses related to economics or marketing. The case describes a scenario in which a managerial accountant is assisting in business decisions relating to factors influencing the profitability of a small manufacturing…

  13. Influence of Polysaccharides from Aloe vera (Aloe barbadensis Miller, Liliaceae on Mechanically Induced Cough in Cats

    Directory of Open Access Journals (Sweden)

    Martina Šutovská

    2010-01-01

    Full Text Available Different plants have been reported to be a source of polysaccharides that possess a great variety of biological activities, including cough suppression. The experiments were aimed on the influence of two polysaccharides isolated from the gel (A, HF1-Z and one from the epidermis (SL-1 of Aloe vera leaves, characterized by chemical composition and structural properties, on the cough reflex. The method of mechanically induced cough was used in conscious cats. A nylon fibre directed individually into the mucous area of the laryngopharyngeal and tracheobronchial airways via endotracheal cannula elicited the cough reflex. Statistical evaluation registered cough reflex indicators (number of cough efforts - NE, cough frequency - NE min–1 intensity of cough attacks during expiration and inspiration - IA+ and IA-, intensity of maximal inspiratory and expiratory cough efforts - IME- and IME+ showed that gel polysaccharide HF1-Z possessed higher cough-suppressing activity than dropropizine, a nonnarcotic peripheral cough suppressant. Their antitussive activity was accompanied mainly with a decrease of NE, IA+ and IA- from both laryngopharyngeal and tracheobronchial mucous areas of the airways. Results of the presented study also showed minimal influence of polysaccharide HF1-Z on expectoration predictor, IME- and IME+. New pharmacodynamic property of polysaccharides isolated from Aloe vera was shown during experiments, which could be a base of their possible therapeutic use in this indication in future.

  14. Extraction and Physicochemical Characterization of Mucilage from Opuntia cochenillifera (L. Miller

    Directory of Open Access Journals (Sweden)

    Mariel Monrroy

    2017-01-01

    Full Text Available The aim of this study was to extract mucilage from O. cochenillifera (L. cacti and determine its functional and physicochemical properties. The best mucilage yield (31% was obtained by nonthermal extraction with hydration. The mucilage has appreciable carbohydrate and protein contents. The phytochemical analysis shown the presence of alkaloids and terpenes/steroids. The Fourier transformed infrared (FT-IR spectrum of the mucilage exhibits typical bands for carbohydrates as O–H, C–H, and –COO−. The mucilage demonstrated water- and oil-holding capacities of 2.78 g water/g dry mucilage and 1.80 g oil/g dry mucilage, respectively, these properties can have a positive effect on the texture of the products when used as a stabilizer. The mildly acidic pH (4.8–5 contributes to its emulsifying capacity. The presence of electrolytes in the mucilage can be of great value in flocculation processes. The mucilage forms low viscosity solutions in the same manner as gum Arabic. Finally, its potential for use as a textile dye remover was evaluated, achieving a 70% removal rate from aqueous solutions. The prepared mucilage exhibits properties that recommend it as a natural material that can be used as an additive in the chemical, food, pharmaceuticals and cosmetics industries, as well as in decontamination processes.

  15. PROPAGAÇÃO "IN VITRO" DA CULTURA DO ABACAXIZEIRO ORNAMENTAL (ANANAS LUCIDUS MILLER

    Directory of Open Access Journals (Sweden)

    Mychelle Karla Teixeira de Oliveira

    2007-01-01

    than in the 0,0 mg L-1 dosage, at a 5% probability level, and similar to the 1,0; 3,0 e 4,0 mg.L-1 dosages. It was observed that in the liquid media treatments there was a higher proliferation of sprouts than in the semi-solid media (11,3 and 9,0 respectively. The acclimatization survival index was of 96% for all treatments.

  16. Aloe barbadensis Miller mediated green synthesis of mono-disperse copper oxide nanoparticles: optical properties.

    Science.gov (United States)

    Gunalan, Sangeetha; Sivaraj, Rajeshwari; Venckatesh, Rajendran

    2012-11-01

    In this paper, we report on the synthesis of nanostructured copper oxide particles by both chemical and biological method. A facile and efficient synthesis of copper oxide nanoparticles was carried out with controlled surface properties via green chemistry approach. The CuO nanoparticles synthesized are monodisperse and versatile and were characterized with the help of UV-Vis, PL, FT-IR, XRD, SEM, and TEM techniques. The particles are crystalline in nature and average sizes were between 15 and 30 nm. The morphology of the nanoparticles can be controlled by tuning the amount of Aloe vera extract. This new eco-friendly approach of synthesis is a novel, cheap, and convenient technique suitable for large scale commercial production and health related applications of CuO nanoparticles. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Carolyn Miller: Tilsløring og afsløring af retorikken

    DEFF Research Database (Denmark)

    2008-01-01

    Retorik er gennem hele sin historie blevet betegnet som en kunst, der må tilsløre sig selv for at lykkes. To felter, hvor retorikken er blevet særdeles effektivt tilsløret, er videnskaben og teknologiens. Denne artikel udforsker de generelle betingelser og begrundelser for at skjule retorikken og...

  18. Gamma irradiation improves the antioxidant activity of Aloe vera (Aloe barbadensis miller) extracts

    International Nuclear Information System (INIS)

    Lee, Eun Mi; Bai, Hyoung-Woo; Lee, Seung Sik; Hong, Sung Hyun; Cho, Jae-Young; Byung, Yeoup Chung

    2012-01-01

    Aloe has been widely used in food products, pharmaceuticals, and cosmetics because of its aromatic and therapeutic properties. In the present study, the ethanolic extracts of aloe gel were gamma-irradiated from 10 to 100 kGy. After gamma irradiation, the color of the ethanolic extracts of aloe gel changed to red; this color persisted up to 40 kGy but disappeared above 50 kGy. Liquid chromatography/mass spectrometry analysis demonstrated the production of a new, unknown compound (m/z=132) after gamma irradiation of the ethanolic extracts of aloe gel. The amount of this unknown compound increased with increasing irradiation up to 80 kGy, and it was degraded at 100 kGy. Interestingly, it was found that gamma irradiation significantly increased the antioxidant activity, as measured by the 1,1-diphenyl-2-picrylhydrazyl-radical scavenging capacity. The antioxidant activity of aloe extract was dramatically increased from 53.9% in the non-irradiated sample to 92.8% in the sample irradiated at 40 kGy. This strong antioxidant activity was retained even at 100 kGy. These results indicate that gamma irradiation of aloe extract can enhance its antioxidant activity through the formation of a new compound. Based on these results, increased antioxidant activity of aloe extracts by gamma rays can be applied to various industries, especially cosmetics, foodstuffs, and pharmaceuticals.

  19. Gamma irradiation improves the antioxidant activity of Aloe vera (Aloe barbadensis miller) extracts

    Science.gov (United States)

    Mi Lee, Eun; Bai, Hyoung-Woo; Sik Lee, Seung; Hyun Hong, Sung; Cho, Jae-Young; Yeoup Chung, Byung

    2012-08-01

    Aloe has been widely used in food products, pharmaceuticals, and cosmetics because of its aromatic and therapeutic properties. In the present study, the ethanolic extracts of aloe gel were gamma-irradiated from 10 to 100 kGy. After gamma irradiation, the color of the ethanolic extracts of aloe gel changed to red; this color persisted up to 40 kGy but disappeared above 50 kGy. Liquid chromatography/mass spectrometry analysis demonstrated the production of a new, unknown compound (m/z=132) after gamma irradiation of the ethanolic extracts of aloe gel. The amount of this unknown compound increased with increasing irradiation up to 80 kGy, and it was degraded at 100 kGy. Interestingly, it was found that gamma irradiation significantly increased the antioxidant activity, as measured by the 1,1-diphenyl-2-picrylhydrazyl-radical scavenging capacity. The antioxidant activity of aloe extract was dramatically increased from 53.9% in the non-irradiated sample to 92.8% in the sample irradiated at 40 kGy. This strong antioxidant activity was retained even at 100 kGy. These results indicate that gamma irradiation of aloe extract can enhance its antioxidant activity through the formation of a new compound. Based on these results, increased antioxidant activity of aloe extracts by gamma rays can be applied to various industries, especially cosmetics, foodstuffs, and pharmaceuticals.

  20. Acemannan and Fructans from Aloe vera (Aloe barbadensis Miller) Plants as Novel Prebiotics.

    Science.gov (United States)

    Quezada, Maria Paz; Salinas, Carlos; Gotteland, Martin; Cardemil, Liliana

    2017-11-22

    The nutraceutical properties of Aloe vera have been attributed to a glucomannan known as acemannan. Recently information has been published about the presence of fructans in Aloe vera but there are no publications about acemannan and fructans as prebiotic compounds. This study investigated in vitro the prebiotic properties of these polysaccharides. Our results demonstrated that fructans from Aloe vera induced bacterial growth better than inulin (commercial FOS). Acemannan stimulated bacterial growth less than fructans, and as much as commercial FOS. Using qPCR to study the bacterial population of human feces fermented in a bioreactor simulating colon conditions, we found that fructans induce an increase in the population of Bifidobacterium spp. Fructans produced greater amounts of short chain fatty acids (SCFA), while the branched-chain fatty acids (BCFA) did not increase with these polysaccharides. Acemannan increased significantly acetate concentrations. Therefore, both Aloe vera polysaccharides have prebiotic potentials.

  1. [The energy metabolism of the Emperor penguin (Aptendodytes patagonica J. F. Miller) in ambient natural conditions].

    Science.gov (United States)

    Dorst, M J

    1976-01-05

    In natural ambient conditions at Possession Island the resting metabolism of the emancipated King Penguin is 50.40 kcal/kg/D. A bird whose insulation is good and which maintains its stomachic temperature at a high level can reduce its heat production by 42% during the long fasting periods which characterize its reproductive cycle, in particular by social and individual thermoregulating behaviour.

  2. Microbiological stabilization of Aloe vera (Aloe barbadensis Miller) gel by high hydrostatic pressure treatment.

    Science.gov (United States)

    Reyes, Juan E; Guanoquiza, Manuel I; Tabilo-Munizaga, Gipsy; Vega-Galvez, Antonio; Miranda, Margarita; Pérez-Won, Mario

    2012-09-03

    The effect of high hydrostatic pressure (HHP) treatment (300, 400 and 500 MPa for 1 and 3 min at 20 °C) on the microbiological shelf-life and microbiota composition of Aloe vera gel during 90 days of storage at 4 °C was investigated. Aerobic mesophilic and psychrotrophic bacteria, as well as moulds and yeasts, were enumerated after HHP treatment and through cold storage. Randomly selected isolates from the count plates were identified by standard methods and the API identification system. Results showed that HHP treatment at or over 400 MPa for 3 min were effective to keep the microbial counts to undetectable levels during the whole storage period, and consequently the microbiological shelf-life of A. vera gel was extended for more than 90 days at 4 °C. The microbiota in the untreated A. vera gel was dominated by Gram-negative bacteria (mostly Rahnella aquatilis) and yeasts (mostly Rhodotorula mucilaginosa). In contrast, Gram-positive bacteria tentatively identified as Arthrobacter spp. and Micrococcus/Kocuria spp. were the predominant microorganisms in samples pressurized at 300 MPa for 1 and 3 min, while Bacillus megaterium predominating in samples treated at 400 MPa for 1 min. At 400 MPa for 3 min and above, the microbial growth was completely suppressed during at least 90 days; however, viable spore-formers were detected by enrichment. Copyright © 2012 Elsevier B.V. All rights reserved.

  3. Aloe barbadensis Miller mediated green synthesis of mono-disperse copper oxide nanoparticles: Optical properties

    Science.gov (United States)

    Gunalan, Sangeetha; Sivaraj, Rajeshwari; Venckatesh, Rajendran

    2012-11-01

    In this paper, we report on the synthesis of nanostructured copper oxide particles by both chemical and biological method. A facile and efficient synthesis of copper oxide nanoparticles was carried out with controlled surface properties via green chemistry approach. The CuO nanoparticles synthesized are monodisperse and versatile and were characterized with the help of UV-Vis, PL, FT-IR, XRD, SEM, and TEM techniques. The particles are crystalline in nature and average sizes were between 15 and 30 nm. The morphology of the nanoparticles can be controlled by tuning the amount of Aloe vera extract. This new eco-friendly approach of synthesis is a novel, cheap, and convenient technique suitable for large scale commercial production and health related applications of CuO nanoparticles.

  4. How James Kept the Pace?; A Look into the Organic Unity of "Daisy Miller"

    Science.gov (United States)

    Movaghati, Sina; Comcar, Milad

    2015-01-01

    Many Critics believe that Henry James has set the definitive standards of modern fiction writing. Undoubtedly his groundbreaking article "The Art of Fiction," which published for the first time in 1884, has a major contribution in developing the theories of fiction writing. The term Organic Unity has derived from a major Formalist…

  5. Modernity in Two Great American Writers' Vision: Ernest Miller Hemingway and Scott Fitzgerald

    Science.gov (United States)

    Keshmiri, Fahimeh; Darzikola, Shahla Sorkhabi

    2016-01-01

    Scott Fitzgerald and Ernest Hemingway, American memorable novelists have had philosophic ideas about modernity. In fact their idea about existential interests of American, and the effects of American system on society, is mirrored in their creative works. All through his early works, Fitzgerald echoes the existential center of his era. Obviously,…

  6. From naughty goods to Nicole Miller: medicine and the marketing of American contraceptives.

    Science.gov (United States)

    Tone, Andrea

    2006-06-01

    In the rich history of modern pharmaceutical advertising in the United States, few medical objects have been as controversial as contraceptives. Condemned in the 1870s as lascivious devices whose commercial visibility would tarnish female sexual purity, contraceptives have in the late twentieth century been repackaged by pharmaceutical companies as the smart, progressive, and fashion-conscious woman's ally. This article explores evolving perspectives on the place of birth control in public spaces from the mid-nineteenth century to the present. In so doing, it elucidates the changes and continuities in the long and contested history of marketing, medicine, sexuality, and reproductive control.

  7. Is the Government of Zambia’s Subsidy to Maize Millers Benefiting Consumers?

    OpenAIRE

    Kuteya, Auckland N.; Jayne, Thomas S.

    2012-01-01

    All governments require accurate information on how the economy functions in order to formulate and implement sound agricultural policies. Policies to ensure food security are no different. Efforts to keep food prices at tolerable levels require information about the competitiveness of the wholesaling, milling, and retailing stages of the food value chain. The main objective for this paper is to better inform policy discussions about the effects of alternative maize pricing and marketing poli...

  8. Discretized Miller approach to assess effects on boundary layer ingestion induced distortion

    Directory of Open Access Journals (Sweden)

    Esteban Valencia

    2017-02-01

    Full Text Available The performance of propulsion configurations with boundary layer ingestion (BLI is affected to a large extent by the level of distortion in the inlet flow field. Through flow methods and parallel compressor have been used in the past to calculate the effects of this aerodynamic integration issue on the fan performance; however high-fidelity through flow methods are computationally expensive, which limits their use at preliminary design stage. On the other hand, parallel compressor has been developed to assess only circumferential distortion. This paper introduces a discretized semi-empirical performance method, which uses empirical correlations for blade and performance calculations. This tool discretizes the inlet region in radial and circumferential directions enabling the assessment of deterioration in fan performance caused by the combined effect of both distortion patterns. This paper initially studies the accuracy and suitability of the semi-empirical discretized method by comparing its predictions with CFD and experimental data for a baseline case working under distorted and undistorted conditions. Then a test case is examined, which corresponds to the propulsor fan of a distributed propulsion system with BLI. The results obtained from the validation study show a good agreement with the experimental and CFD results under design point conditions.

  9. Review: Melanie Mauthner, Maxine Birch, Julie Jessop & Tina Miller (Eds. (2002. Ethics in Qualitative Research

    Directory of Open Access Journals (Sweden)

    Mechthild Kiegelmann

    2004-01-01

    Full Text Available This book is a collection of theoretical thoughts about ethics in qualitative research. A coherent group of feminists propose issues to consider in research from a perspective of an ethics of care. The authors illustrate their argu­ments with examples from their own research ex­peri­ences. Examples from actual research, e.g. in the area of health studies are provided. This book is well suited for graduate students to learn about ethics in qualitative research. URN: urn:nbn:de:0114-fqs0401276

  10. Burnaia Miller, 2001 (Gastropoda, Heterobranchia, Nudibranchia): a facelinid genus with an Aeolidiidae's outward appearance

    Science.gov (United States)

    Carmona, Leila; Pola, Marta; Gosliner, Terrence M.; Cervera, Juan Lucas

    2015-09-01

    In recent years, several morphological and molecular analyses have been undertaken to study the phylogenetic systematics of Aeolidiidae members. The monospecific genus Burnaia could not be included in the previous analysis, due to the lack of material. This study includes two specimens of Burnaia helicochorda from Australia and places them in their systematic position using two mitochondrial and one nuclear genes (COI and 16S, and H3, respectively). A description of its anatomy is also included with colour pictures of the animal and scanning electron micrographs of radula and jaws. Based on our results, B. helicochorda does not belong to Aeolidiidae since it appears nested among some facelinids.

  11. MACARRÃO ADICIONADO DE ORA-PRO-NÓBIS (PERESKIA ACULEATA MILLER DESIDRATADO

    Directory of Open Access Journals (Sweden)

    Débora Regina da Cunha ROCHA

    2009-06-01

    Full Text Available

    A utilização de alimentos alternativos para o combate à fome na população de baixa renda é assunto que tem recebido atenção no Brasil nos últimos anos. As hortaliças não-convencionais constituem uma alternativa para populações carentes por serem boas fontes de nutrientes, apresentarem fácil disponibilidade, além de baixo valor de mercado. Diante disso, o presente trabalho objetivou elaborar e caracterizar física, química e sensorialmente o macarrão tipo talharim com diferentes proporções de ora-pro-nóbis. O ora-pro-nóbis desidratado foi caracterizado quanto sua composição física e química, além de sua utilização do para elaboração das massas de macarrão tipo talharim com diferentes concentrações (1,0; 1,5 e 2,0%, estas foram submetidas a pesquisa de preferência e a formulação preferida foi avaliada quanto a aceitabilidade. O ora-pro-nóbis desidratado apresentou consideráveis teores de proteínas (22,93%, fibras (12,64% e cinzas (18,07%. Dentre as formulações testadas a de maior preferência, formulação com 2,0 % de ora-pro-nóbis, se destacou por apresentar maior conteúdo de proteínas, fibras e cinzas quando comparado com o macarrão convencional. Os resultados demonstram que o uso de 2,0% de ora-pro-nóbis desidratado no macarrão tipo talharim elevou os teores de proteínas, fibras e cinzas em relação ao macarrão convencional. Na avaliação sensorial, o macarrão com adição de ora-pro-nóbis foi aceito por apresentar índice de aceitabilidade de 92,0%. A utilização do ora-pro-nóbis na elaboração de vários produtos alimentícios contribuirá para aumento do seu cultivo, bem como para a melhoria da qualidade da dieta da população.

  12. Genetics Home Reference: cytochrome c oxidase deficiency

    Science.gov (United States)

    ... features known as Leigh syndrome . The signs and symptoms of Leigh syndrome include loss of mental function, movement problems, hypertrophic cardiomyopathy, eating difficulties, and brain abnormalities. Cytochrome c oxidase ...

  13. Disease: H00754 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available e 6 (MEGDEL) caused by mutation in the SERAC1 gene, is characterized by deafness, encephalopathy, and Leigh-...lglutaconic aciduria type IV with sensorineural deafness, encephalopathy and Leigh-like syndrome) caused by

  14. Free Energy Barrier for Molecular Motions in Bistable [2]Rotaxane Molecular Electronic Devices

    Science.gov (United States)

    2009-04-10

    Org. Chem. 2001, 66, 3559– 3563. (69) Leigh, D. A.; Murphy, A.; Smart, J. P.; Deleuze , M. S.; Zerbetto, F. J. Am. Chem. Soc. 1998, 120, 6458–6467. (70...Leigh, D. A.; Troisi, A.; Zerbetto, F. Chem. Eur. J. 2001, 7, 1450– 1454. (71) Deleuze , M. S.; Leigh, D. A.; Zerbetto, F. J. Am. Chem. Soc. 1999, 121

  15. 77 FR 75838 - Regional Reliability Standard PRC-006-SERC-01; Automatic Underfrequency Load Shedding Requirements

    Science.gov (United States)

    2012-12-26

    ... 560,000 square miles in a sixteen- state area in the southeastern and central United States (all of... Brayton Point, LLC, Dominion Energy Manchester Street, Inc., Elwood Energy, LLC, Kincaid Generation, LLC...

  16. 3Corners of the World / Joosep Sang

    Index Scriptorium Estoniae

    Sang, Joosep

    2009-01-01

    Arvustused : Robert Jürjendal, Petri Kuljuntausta, David Rothenberg. 3Corners of the World. [Tallinn] : Terra Nova Music, 2008. Nadia ja Fragile. Uhke ali. [Tallinn] : Nadia & Fragile, 2008. UMA. Civitas Soli. [Tallinn] : Elwood, 2008. Uutest heliplaatidest

  17. Sixteenth workshop on geothermal reservoir engineering: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W. (Stanford Geothermal Program)

    1991-01-25

    The Sixteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 23-25, 1991. The Workshop Banquet Speaker was Dr. Mohinder Gulati of UNOCAL Geothermal. Dr. Gulati gave an inspiring talk on the impact of numerical simulation on development of geothermal energy both in The Geysers and the Philippines. Dr. Gulati was the first recipient of The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy. Dr. Frank Miller presented the award. The registered attendance figure of one hundred fifteen participants was up slightly from last year. There were seven foreign countries represented: Iceland, Italy, Philippines, Kenya, the United Kingdom, Mexico, and Japan. As last year, papers on about a dozen geothermal fields outside the United States were presented. There were thirty-six papers presented at the Workshop, and two papers were submitted for publication only. Attendees were welcomed by Dr. Khalid Aziz, Chairman of the Petroleum Engineering Department at Stanford. Opening remarks were presented by Dr. Roland Horne, followed by a discussion of the California Energy Commission's Geothermal Activities by Barbara Crowley, Vice Chairman; and J.E. ''Ted'' Mock's presentation of the DOE Geothermal Program: New Emphasis on Industrial Participation. Technical papers were organized in twelve sessions concerning: hot dry rock, geochemistry, tracer injection, field performance, modeling, and chemistry/gas. As in previous workshops, session chairpersons made major contributions to the program. Special thanks are due to Joel Renner, Jeff Tester, Jim Combs, Kathy Enedy, Elwood Baldwin, Sabodh Garg, Marcel0 Lippman, John Counsil, and Eduardo Iglesias. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Angharad Jones, Rosalee Benelli, Jeanne Mankinen, Ted Sumida, and Terri A. Ramey who also

  18. Impacto da salinidade no desenvolvimento e crescimento de mudas de carnaúba (Copernicia prunifera (Miller H.E.Moore Impact of salinity on development and growing of ‘carnaúba’ (Copernicia prunifera (Miller H.E. Moore seedlings

    Directory of Open Access Journals (Sweden)

    Samia J. R. Holanda

    2011-01-01

    Full Text Available Identificar o impacto da salinidade no desenvolvimento e crescimento de espécies resistentes a altas concentrações salinas é de fundamental importância para a recuperação de áreas salinizadas do semiárido nordestino brasileiro. Visando contribuir para a resolução desta problemática, o presente trabalho avaliou o efeito de diferentes níveis de salinidade para o desenvolvimento e o crescimento da carnaúba, espécie nativa e de extremo valor econômico para a região. Os níveis analisados foram: 0, 25, 50, 100 mM de NaCl, correspondente a uma condutividade elétrica de 2.0, 4.6, 7.1, 9.6, 12 dS m-1, respectivamente. Utilizou-se o delineamento inteiramente casualisado, com cinco tratamentos e quatro repetições, e se analisaram as variáveis altura da parte aérea, largura da parte aérea da folha, comprimento da raiz principal, peso da matéria seca, razão da matéria seca parte aérea/raiz e taxa de sobrevivência. Os tratamentos com 25 e 50 mM de NaCl não afetaram a sobrevivência inicial da planta. Concentrações maiores ou iguais que 75 mM de NaCl reduziram a produção de biomassa e a taxa de sobrevivência, em quase 50%; portanto, a produção de plantas nesses níveis de sal não é recomendada.To identify the impact of salinity on the development and growth of species resistant to high salt concentration is fundamental for restoration of salty areas in the Northeast brazilian semi-arid region. Seeking to solve this problem this work evaluated the effect of different salt levels on the development and growth of ‘carnauba’, a native species with high economical value to the region. The levels analyzed were: 0, 25, 50, 75 and 100 mM of NaCl, corresponding to an electrical conductivity of 2.0, 4.6, 7.1, 9.6 and 12 dS m-1, respectively. A completely randomized experimental design with five treatments and four replicates was used. The analyzed variables were aerial height, aerial width, main root length, dry weight, aerial/root ratio and survival rate. Treatments with 25 and 50 mM of NaCl did not affect the initial plant survival. Concentration levels greater or equal to 75 mM of NaCl reduced the biomass production and the survival rate in almost 50%. Therefore, plant production at these salt levels is not recommended.

  19. Creating a multi-gas proxy for Delta 14C and atmospheric fossil fuel-CO2. Kevin Coakley, John Miller , Scott Lehman, Stephen Montzka, Colm Sweeney, Arlyn Andrews , Ben Miller

    Science.gov (United States)

    Coakley, K. J.; Miller, J. B.; Lehman, S.; Montzka, S. A.; Andrews, A. E.; Miller, B. R.

    2013-12-01

    The C14:C12 ratio of atmospheric CO2 (expressed as Delta 14C) is the gold standard measurement to derive the portion of observed atmospheric CO2 gradients resulting from combustion of fossil fuels (CO2-ff). This is because fossil fuels are devoid of 14C, unlike all other sources and sinks that impact atmospheric Delta14C. With enough 14C measurements, independent, 'top-down', estimation of US fossil fuel-CO2 emissions should be possible. However, our ability to make carbon-14 measurements is severely constrained by cost, accessibility to accelerator mass spectrometers (AMS) and the volume of air required to make high precision (~0.2 %) measurements of 14CO2 (mixing ratio is ~ 4e-16 mol/mol). Thus, Delta 14C is currently measured in only a small subset of NOAA/ESRL Global Monitoring Division (GMD) tall-tower and aircraft air samples. Here, we present a Projection Pursuit Regression (PPR) model to predict CO2-ff measured at different times and altitudes in terms of surrogate gases that are more widespread and relatively inexpensive to measure. This method would, in effect, allow expansion of Delta 14C measurements by factor of ~3 or 4 throughout North America. To create a proxy for CO2-ff, we take advantage of the observed correlations between (Delta 14C-derrived) CO2-ff and regional-scale enhancements of a wide array of anthropogenic gases, like CO, SF6, and halo- and hydro-carbons. We select the complexity and form of the PPR model by cross validation where validation data prediction error is minimized. In cross validation, the prediction model is based on the training data and not the validation data. We quantify prediction model performance with test data excluded from the model development process. According to cross validation, the PPR model is superior to a simpler linear model. Comparison with test CO2-ff data shows that CO2-ff can be predicted with a root mean square error of 1.1 ppm, only slightly higher than the Delta 14C-precision limit for CO2-ff of 1 ppm. Applying the PPR model to the large NOAA/ESRL/GMD database of surrogate gases, we can create a large set of synthetic CO2-ff data for the US. Finally, we will discuss the application of this large data set of lower-precision CO2-ff to top down determination of US fossil fuel CO2 emissions by presenting results from an Observation System Simulation Experiment (OSSE).

  20. Morphological and morphometric characterization of the new records of the East European vole (Microtus levis Miller, 1908 from northeast Iran

    Directory of Open Access Journals (Sweden)

    Fatemeh Ghorbani

    2015-09-01

    Full Text Available Thirteen specimens of Microtus levis were collected from Golestan province, northeast Iran. The specimens were studied based on their external characters, skull and dental morphology, and specially karyology. Specimens of M. levis from the northeast of Iran were also compared with other species of the arvalis group from Iran and specimens of M. levis from Turkey. The specimens demonstrated that 2n=54 and fundamental number FN=54. The karyological results were similar between specimens from northeast Iran and those from Turkey, but they were different from specimens of Europe. In addition, the morphometric characters of M. levis, including head and body length (mean=105.77±7.53, length of condylobasal (mean=24.96±0.97, length of bullae (mean=6.57±0.34, and dental characters consisting of maxillary tooth row (mean=6.17±0.25 and mandibular tooth row (mean=5.60±0.33, were different from those of other species of the arvalis group.

  1. Chemical variability of essential oils of Lippia alba (Miller) N. E. Brown growing in Costa Rica and Argentina.

    Science.gov (United States)

    Ricciardi, Gabriela; Cicció, José F; Ocampo, Rafael; Lorenzo, Daniel; Ricciardi, Armando; Bandoni, Arnaldo; Dellacassa, Eduardo

    2009-06-01

    Lippia alba (Verbenaceae) is a shrub whose essential oil has important biological, pharmacological, and aromatizing properties. The species has a natural range from Central America to Argentina, being cultivated for its commercial value in Brazil, Argentina and Guatemala, and has been introduced into India and Spain. To reach the economic potential of the plant, the present study was aimed at evaluating L. alba for different chemotypes. The composition of the essential oil from two native populations of L. alba, collected from Argentina and two accessions from Costa Rica, were screened by GC and GC-MS. The results obtained led us to adopt the concept of a biodistribution map, as was proposed previously for the species, representing an approach to the natural biological distribution of the species in America based on the chemotypes described and their geographical distribution. Moreover, the biodiversity reported for the species (seven of eight chemotypes described for L. alba are present in Argentina) suggests the southern region of South America as the centre of distribution for L. alba.

  2. The Effect of Salinity Stress on the Growth, quantity and quality of Essential oil of Lavender (Lavandula angustifulia Miller)

    OpenAIRE

    sarah khorasaninejad; Hassan Soltanloo; Javad Hadian; Sadegh Atashi

    2017-01-01

    Introduction: Plants are usually exposed to different environmental stresses which limit their growth and productivity as well as cause considerable loss of worldwide agricultural production. One of the most important factors affecting plant and production of secondary metabolites is the salt stress. Salinity of soil or water is one of major stress, obstacles to increase production in plant growing areas throughout the world and especially in arid and semi-arid regions it can severely limit p...

  3. DOE Zero Energy Ready Home Case Study: Amerisips Homes — Miller-Bloch Residence, Johns Island, SC

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-09-01

    For this DOE Zero Energy Ready Home that won a Custom Builder award in the 2014 Housing Innovation Awards, the builder uses structural insulated panels to construct the entire building shell, including the roof, walls, and floor of the home.

  4. Damage caused by Tetranychus Merganser Bondreaux (Acari: Tetranychidae on Nopal Verdura Opuntia Ficus-Indica (L. Miller during winter

    Directory of Open Access Journals (Sweden)

    J. Lima-Espíndola

    2017-09-01

    Full Text Available The spider mite Tetranychus merganser occurs in some crops in Mexico and USA. This mite could be considered a potential pest in countries like Japan. In this work we recorded the damages that T. merganser causes to the nopal verdura (prickly pear vegetable crop in one of the principal cactus crop regions of Mexico.

  5. Organic Analysis in the Miller Range 090657 CR2 Chondrite: Part 3 C and N Isotopic Imaging

    Science.gov (United States)

    Messenger, S.; Nakamura-Messenger, K.; Elsila, J. E.; Berger, E. L.; Burton, A. S.; Clemett, S. J.; Cao, T.

    2016-01-01

    Primitive carbonaceous chondrites contain a wide variety of organic material, ranging from soluble discrete molecules to insoluble nanoglobules of macro-molecular carbon. The relationship between the soluble organic molecules, macromolecular organic material, and host minerals are poorly understood. Large H, C and N isotopic anomalies suggest some organic components formed in low-T interstellar or outer Solar System environments. The highest isotope anomalies occur in m-scale inclusions in the most primitive materials, such as cometary dust and the least altered carbonaceous chondrites. Often, the hosts of these isotopically anomalous 'hotspots' are discrete organic nanoglobules that probably formed in the outermost reaches of the protosolar disk or cold molecular cloud. Molecular and isotopic studies of meteoritic organic matter are aimed at identifying the chemical properties and formation processes of interstellar organic materials and the subsequent chemical evolutionary pathways in various Solar System environments. The combination of soluble and insoluble analyses with in situ and bulk studies provides powerful constraints on the origin and evolution of organic matter in the Solar System. Using macroscale extraction and analysis techniques as well as microscale in situ observations we have been studying both insoluble and soluble organic material in primitive astromaterial samples. Here, we present results of bulk C and N isotopic measurements and coordinated in situ C and N isotopic imaging and mineralogical and textural studies of carbonaceous materials in a Cr2 carbonaceous chondrite. In accompanying abstracts we discuss the morphology and distribution of carbonaceous components and soluble organic species of this meteorite.

  6. Antihyperglycemic Activity of the Leaves from Annona cherimola Miller and Rutin on Alloxan-induced Diabetic Rats

    Science.gov (United States)

    Calzada, Fernando; Solares-Pascasio, Jesús Iván; Ordoñez-Razo, R. M.; Velazquez, Claudia; Barbosa, Elizabeth; García-Hernández, Normand; Mendez-Luna, David; Correa-Basurto, José

    2017-01-01

    Background: Annona cherimola, known as “chirimoya” has been reported in Mexican traditional medicine for the treatment of diabetes. Objective: The aims of the present study were to validate and assess the traditional use of A. cherimola as an antidiabetic agent. Materials and Methods: The ethanol extract from A. cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg), and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats. In addition, oral glucose tolerance test (OGTT) and oral sucrose tolerance test (OSTT) were performed in normoglycemic rats. Molecular docking technique was used to conduct the computational study. Results: Bioassay-guided fractionation of EEAc afforded as major antihyperglycemic compound, rutin. EEAc attenuated postprandial hyperglycemia in acute test using AITD rats (331.5 mg/dL) carrying the glycemic levels to 149.2 mg/dL. Rutin after 2 h, attenuated postprandial hyperglycemia in an acute assay using AITD rats such as EEAc, with maximum effect (150.0 mg/dL) being seen at 4 h. The antihyperglycemic activities of EEAc and rutin were comparable with acarbose (151.3 mg/dL). In the subchronic assay on AITD rats, the EEAc and rutin showed a reduction of the blood glucose levels since the 1st week of treatment, reaching levels similar to normoglycemic state (116.9 mg/kg) that stayed constant for the rest of the assay. OGTT and OSTT showed that EEAc and rutin significantly lowered blood glucose levels in normoglycemic rats at 2 h after a glucose or sucrose load such as acarbose. Computational molecular docking showed that rutin interacted with four amino acids residues in the enzyme α-glucosidase. Conclusion: The results suggest that rutin an α-glucosidase inhibitor was responsible in part of the antihyperglycemic activity of A. cherimola. Its in vivo antihyperglycemic activity is in good agreement with the traditional use of A. cherimola for the treatment of diabetes. SUMMARY The ethanol extract from Annona cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg) and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats. The results suggest that rutin; an α-glucosidase inhibitor was responsible in part of the antihyperglycemic activity of A. cherimola. Its in vivo antihyperglycemic activity is in good agreement with the traditional use of A. cherimola for the treatment of diabetes. Abbreviations Used: EEAc: The ethanol extract from Annona cherimola, AITD: Alloxan-induced type 2 diabetic rats, OGTT: Oral glucose tolerance test, OSTT: Oral sucrose tolerance test, DM: Diabetes mellitus PMID:28250646

  7. Influence of Self-Phase Modulation on 8 and 16-Channel DWDM System with NRZ and Miller Coding

    Directory of Open Access Journals (Sweden)

    Tomáš Ivaniga

    2015-06-01

    Full Text Available This article is focused SPM (Self-Phase Modulation, whic affects the signal transmision in fully optical communication systems. With the advent of WDM (Wavelength Division Multiplexing the optical power in optical fiber. For WDM are used weak lasers with 16 or 32 channels. A power of these channels are summed and then we work with the power in fiber about 0.5W which is dangerous for eyes. Therefore for design of the optical network over 10Gbit/s per 1 channel WDM, it is obligation to solve this nonlinear phenomenon. In program package OptSim was created topology 8 and 16- channel DWDM (Dense Wavelenght Division Multiplexing system according to standard ITU-T (International Telecommunication Union-Telecommunication G.694.1 with channel spacing of 25GHz, transmission power of 1 and 15 dBm, with transmision speed of 10Gbit/s and two coding types to see the SPM.

  8. Suur Miller ja Väike Killer / Tiit Palu, Andrus Allikvee ; intervjueerinud Anu Tonts ja Sven Karja

    Index Scriptorium Estoniae

    Palu, Tiit, 1970-

    1997-01-01

    Vanemuises esietenduvad 19. mail Arthur Milleri 'Sööst kuristikku' (lavastaja Andrus Allikvee) ja 20. mail Tracy Lettsi 'Killer Joe' (lavastaja Tiit Palu). Postimehe küsitlus lavastajatele (vastavad samadele küsimustele)

  9. Evaluation of Aloe vera (Aloe barbadensis Miller Antioxidant Activity and Some of the Morphological Characteristics in Different Vermicompost Field

    Directory of Open Access Journals (Sweden)

    Z.Yavari

    2013-04-01

    Full Text Available Construction and function of effective substances of medicinal plants are influenced by environmental factors such as deficiency or increased of nutrients in the soil and substrates. Therefore, a greenhouse experiment was performed in completely randomized design with four treatments and three replications. The effects of vermicompost were examined on the morphological and phytochemical features in aloe vera. Treatments consisted of four vermicompost percentages (0%, 15%, 30% and 45% in humus soil. The considered factors were leaf weight, gel fresh weight, gel dry weight, the antioxidant capacity of the gel, glucomannan of gel, flavonoids and phenols of gel, and anthocyanins of cortex. data analysis showed that the maximum of leaf weight, gel weight, dry weight of gel and gel glucomannan was obtained in 45% of vermicompost. The maximum of gel phenol, antioxidant activity of gel and anthocyanins of cortex belonged to 30% of vermicompost and gel flavonoid in 15% of vermicompost. To achieve maximum antioxidant capacity and optimum amount of active substances, more studies and application of different field of vermicompost are required in order to increase the value of medicinal properties.

  10. Evaluation of Aloe vera (Aloe barbadensis Miller Antioxidant Activity and Some of the Morphological Characteristics in Different Vermicompost Field

    Directory of Open Access Journals (Sweden)

    Z. Yavari

    2014-02-01

    Full Text Available Normal 0 false false false EN-US X-NONE FA Construction and function of effective substances of medicinal plants are influenced by environmental factors such as deficiency or increased of nutrients in the soil and substrates. Therefore, a greenhouse experiment was performed in completely randomized design with four treatments and three replications. The effects of vermicompost were examined on the morphological and phytochemical features in aloe vera. Treatments consisted of four vermicompost percentages (0%, 15%, 30% and 45% in humus soil. The considered factors were leaf weight, gel fresh weight, gel dry weight, the antioxidant capacity of the gel, glucomannan of gel, flavonoids and phenols of gel, and anthocyanins of cortex. data analysis showed that the maximum of leaf weight, gel weight, dry weight of gel and gel glucomannan was obtained in 45% of vermicompost. The maximum of gel phenol, antioxidant activity of gel and anthocyanins of cortex belonged to 30% of vermicompost and gel flavonoid in 15% of vermicompost. To achieve maximum antioxidant capacity and optimum amount of active substances, more studies and application of different field of vermicompost are required in order to increase the value of medicinal properties. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri","sans-serif";}

  11. D. McKenzie, C. Miller and D.A. Falk, eds. The Landscape Ecology of Fire [book review

    Science.gov (United States)

    Eric J. Gustafson

    2012-01-01

    In the Foreword of this volume is the statement that "landscape ecology is the 'glue' that holds ecosystem theory together and nowhere is that more evident than in the study of wildland fire ecology." The Landscape Ecology of Fire summarizes how landscape ecology has contributed to, and been formed by, the study...

  12. 77 FR 62238 - Alan B. Miller and Universal Health Services; Analysis of Agreement Containing Consent Orders To...

    Science.gov (United States)

    2012-10-12

    ... largest hospital management companies in the United States, with 2011 revenues totaling approximately $7.5... with UHS post-divestiture, the Consent Agreement requires a second UHS hospital, Mesilla Valley Hospital (``Mesilla Valley''), located in Las Cruces, New Mexico, to be divested if the original...

  13. Effects of 2,4-D and 4-CPA on yield and quality of the tomato, Lycopersicon esculentum Miller (Solanaceae)

    DEFF Research Database (Denmark)

    Gemici, Meliha; Türkyilmaz, B.; Tan, Kit

    2007-01-01

    Synthetic plant growth substances augment plant growth when applied at specific concentrations; they are also reported as without causing significant increases in the amount of internal plant hormones. Exceeding recommended dosages, however, affects yield and quality adversely. An experiment, to ...

  14. Visiting Educational Scholarship Training Program at the University of Miami, Miller School of Medicine: A Global Opportunity to Learn.

    Science.gov (United States)

    Galardi, Nicholas; Ciminero, Matthew; Thaller, Seth; Salgado, Christopher

    2015-06-01

    The Visiting Educational Scholarship Training Program, started by the University of Miami's Division of Plastic and Reconstructive Surgery, was designed to uphold the institution's founding mission: the education of our future medical leaders as well as the promotion of health of our local, regional, national, and international communities. It offers the opportunity for international medical students and training physicians to be educated and get exposure to the field of plastic surgery in a United States training institution.

  15. Measurement of the transmittance of edible films of aloe vera (barbadensis miller) and cassava starch using optical fibers trifurcated

    Science.gov (United States)

    Díaz, L.; Reales, J.; Torres, C.

    2017-01-01

    In Colombia, especially in the Atlantic Coast it is produced and marketed the costeño cheese, an indigenous product of the gastronomy of this region, but the prolonged exposure of this product to the environment leads to microbial contamination and non-enzymatic rancidity. For this reason the transmittance of an edible coating based in aloe vera gel and cassava starch to preserve costeño cheese was evaluated using trifurcated optical fibers. The results become a tool for the selection of treatments in making edible films and their subsequent use in coatings for various types of food products.

  16. Symptomatic Recovery in Miller Fisher Syndrome Parallels Vestibular–Perceptual and not Vestibular–Ocular Reflex Function

    OpenAIRE

    Seemungal, Barry M.; Masaoutis, Panos; Green, David A.; Plant, Gordon T.; Bronstein, Adolfo M.

    2011-01-01

    08.05.15 Kb. Ok to add published oa paper in spiral Unpleasant visual symptoms including oscillopsia and dizziness may occur when there is unexpected motion of the visual world across the subjects retina ( retinal slip ) as in an acute spontaneous nystagmus or on head movement with an acute ophthalmoplegia. In contrast, subjects with chronic ocular dysmotility, e.g., congenital nystagmus or chronic progressive external ophthalmoplegia, are typically symptom free. The adaptive processes tha...

  17. COMPOSITION OF THE VOLATILE OIL EXTRACTED FROM ABIES ALBA MILLER LEAVES PARASITIZED BY MELAMPSORELLA CARYOPHYLLACEARUM (DC. J. SCHRÖT.

    Directory of Open Access Journals (Sweden)

    MANOLIU ALEXANDRU

    2011-12-01

    Full Text Available Researches results highlights both qualitative and quantitative influences exercised by the parasitic species Melampsorella caryophyllacearum on the composition of the volatile oil extracted from Abies alba leaves, prelevated in 2010 from Oituz river basin (Bacău county. The isolation of volatile oils has been realized by hydrodistillation in Neo-Clavenger installation, followed by gas-chromatography coupled with mass spectrometry analysis. The increase of the monoterpenes concentration in the parasitized sample could be explained by the degradative action of the enzymes produced by the pathogenic species Melampsorella caryophyllacearum or by the incapacity of syntheses from these monoterpenes of some compounds presenting a more complex structure in the parasitized plant case.

  18. Research Review: Emanuel Miller Memorial Lecture 2012 ? Neuroscientific studies of intervention for language impairment in children: interpretive and methodological problems

    OpenAIRE

    Bishop, D V M

    2013-01-01

    Background Our ability to look at structure and function of a living brain has increased exponentially since the early 1970s. Many studies of developmental disorders now routinely include a brain imaging or electrophysiological component. Amid current enthusiasm for applications of neuroscience to educational interventions, we need to pause to consider what neuroimaging data can tell us. Images of brain activity are seductive, and have been used to give credibility to commercial interventions...

  19. Ring Chromosome 17 Not Involving the Miller-Dieker Region: A Case with Drug-Resistant Epilepsy.

    Science.gov (United States)

    Coppola, Antonietta; Morrogh, Deborah; Farrell, Fiona; Balestrini, Simona; Hernandez-Hernandez, Laura; Krithika, S; Sander, Josemir W; Waters, Jonathan J; Sisodiya, Sanjay M

    2017-12-01

    Chromosomal abnormalities are often identified in people with neurodevelopmental disorders including intellectual disability, autism, and epilepsy. Ring chromosomes, which usually involve gene copy number loss, are formed by fusion of subtelomeric or telomeric chromosomal regions. Some ring chromosomes, including ring 14, 17, and 20, are strongly associated with seizure disorders. We report an individual with a ring chromosome 17, r(17)(p13.3q25.3), with a terminal 17q25.3 deletion and no short arm copy number loss, and with a phenotype characterized by intellectual disability and drug-resistant epilepsy, including a propensity for nonconvulsive status epilepticus.

  20. Biografema como estratégia biográfica : escrever uma vida com Nietzsche, Deleuze, Barthes e Henry Miller

    OpenAIRE

    Luciano Bedin da Costa

    2010-01-01

    Como escrever uma vida? Essa pergunta aparentemente simples é a questão que movimenta este texto. A escrita de vida – chamada aqui de biografia (bíος - bíos, vida e γραφή – gráphein, escrever) – é um tema transversal, compreendendo não somente a literatura, como também outros domínios das Ciências Humanas e da Saúde, como a psicologia, educação, antropologia, história e ciências sociais. A bio-grafia comporta um tecido amplo de operacionalizações e metodologias; ela aparece nas histórias de v...

  1. Effect of high hydrostatic pressure on functional properties and quality characteristics of Aloe vera gel (Aloe barbadensis Miller).

    Science.gov (United States)

    Vega-Gálvez, Antonio; Miranda, Margarita; Aranda, Mario; Henriquez, Karem; Vergara, Judith; Tabilo-Munizaga, Gipsy; Pérez-Won, Mario

    2011-12-01

    The aim of this study was to evaluate the effects of high hydrostatic pressure treatment at three pressure levels (300, 400 and 500Mpa) on the functional and quality characteristics of Aloe vera gel including vitamin C and E, aloin, minerals, phenolic content and antioxidant activity. The results show that HHP exerted a clear influence on minerals content, vitamin C and E content, antioxidant activity, total phenolic and aloin content. After 35days of storage all treated samples presented a decrease in mineral content, except for phosphorus. Total phenolic content and vitamin C and E content decreased at high pressures (500MPa), while all pressurised samples showed a higher antioxidant activity and aloin content than untreated sample after 35days of storage. The maximum values of antioxidant activity and aloin were 6.55±1.26μg/ml at 300MPa and 24.23±2.27mg/100g d.m. at 400MPa. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. 78 FR 66748 - Smith Miller and Patch Inc. et al.; Proposal to Withdraw Approval of 14 New Drug Applications...

    Science.gov (United States)

    2013-11-06

    ... Ave., Glendale, CA 91201. NDA 017861 Acthar Gel Synthetic Armour (seractide acetate) Pharmaceutical Co... the Center for Drug Evaluation and Research proposes to issue an order under section 505(e) of the..., all issues relating to the legal status of the drug products covered by these applications. An...

  3. The morphological and anatomical studies on endemic crocus biflorus miller subsp. Pulchricolor (herbert) mathew (iridaceae) in turkey

    International Nuclear Information System (INIS)

    Akyol, Y.

    2014-01-01

    In this study, the morphological and anatomical characteristics of Crocus biflorus subsp. pulchricolor (Iridaceae)were investigated. The subsp. pulchricolor has, 4 leaves, 1 mm broad, bracts drying brownish. these properties are characteristics of these plants. In anatomical studies, cross-sections of the root, stem and leaves were examined. These parts photographed and compared with the other crocus and Iridaceae family species. (author)

  4. Measurement of the transmittance of edible films of aloe vera (barbadensis miller) and cassava starch using optical fibers trifurcated

    International Nuclear Information System (INIS)

    Díaz, L; Torres, C; Reales, J

    2017-01-01

    In Colombia, especially in the Atlantic Coast it is produced and marketed the costeño cheese, an indigenous product of the gastronomy of this region, but the prolonged exposure of this product to the environment leads to microbial contamination and non-enzymatic rancidity. For this reason the transmittance of an edible coating based in aloe vera gel and cassava starch to preserve costeño cheese was evaluated using trifurcated optical fibers. The results become a tool for the selection of treatments in making edible films and their subsequent use in coatings for various types of food products. (paper)

  5. Multiple, life-compatible, congenital physical deformities in association with splenic lymphangiomatosis in Zoogoneticus tequila (Webb & Miller, 1998

    Directory of Open Access Journals (Sweden)

    Mariarita Romanucci

    2016-12-01

    Full Text Available The present case describes an adult female Zoogoneticus tequila showing a congenital, marked shortening with left deviation of the upper and lower jaws, in association with microphthalmia of the left eye. The fish was normally fed and had a normal reproductive behaviour. After spontaneous death occurred at an advanced age, the fish was submitted for necropsy examination, which revealed the presence of an oval, 1 cm × 0.5 cm × 0.5 cm in size, cystic structure containing clear amber fluid, located in the coelomic cavity, in place of the spleen. Histopathological examination revealed multiple cystic spaces empty or filled with a slightly eosinophilic, homogenous, proteinaceous material, and lined by flattened, vimentin-positive endothelial-like cells. Residual parts of splenic tissue were also admixed with cystic spaces, suggesting a final diagnosis of cystic lymphangiomatosis of the spleen, which has not been previously described in fish. This is the first report of multiple, life-compatible, congenital physical deformities in association with splenic lymphangiomatosis in Zoogoneticus tequila.

  6. Health hazard evaluation report HETA 84-194-1549, American Federation of Grain Millers, Local 118, Superior, Wisconsin

    Energy Technology Data Exchange (ETDEWEB)

    Ahrenholz, S.H.

    1985-01-01

    Bulk and air samples were analyzed for carbon-tetrachloride (56235), chloroform (67663), ethylene-dichloride (107062), 1,2-dichloroethylene (540590), carbon-disulfide (75150), methyl-bromide (74839), methylene-chloride (75092), and ethylene-dibromide (106934) in a grain shipment (SIC-5153) in Superior, Wisconsin in February, 1984. The grain was aboard railcars located in a railroad yard waiting to be unloaded. The evaluation was requested by a union local and the district's Congressman due to concern that the grain had been heavily treated with chemical fumigants. The author notes that the measured concentrations should not be interpreted as worker exposures as the samples were collected for identification purposes only and were taken at locations considered unrealistic for a worker's breathing zone. Recommendations include requiring workers opening fumigated railcars to wear self contained breathing apparatus and implementing a method of tracking grain fumigation during passage through the grain handling system.

  7. 75 FR 9860 - Release, Handling, and Protection of Restricted Information

    Science.gov (United States)

    2010-03-04

    ... element or activity that requires specified services or products to be provided under a contract. (b)(1... Pomponio, NASA Headquarters, Office of Procurement, Contract Management Division, Washington, DC 20546...: Leigh Pomponio, Office of Procurement, Contract Management Division, (202) 358-0592, e-mail: leigh...

  8. An interdisciplinary approach to identify adaptation strategies that enhance flood resilience and urban liveability

    DEFF Research Database (Denmark)

    Rogers, B. C.; Bertram, N.; Gunn, Alex

    This paper provides guidance on how to identify and design the most suitable climate adaptation strategies for enhancing the liveability and flood resilience of urban catchments. It presents findings from a case study of Elwood, a coastal Melbourne suburb regularly affected by flooding. The resea......This paper provides guidance on how to identify and design the most suitable climate adaptation strategies for enhancing the liveability and flood resilience of urban catchments. It presents findings from a case study of Elwood, a coastal Melbourne suburb regularly affected by flooding...

  9. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

    Directory of Open Access Journals (Sweden)

    Brody LP

    2017-09-01

    Full Text Available Leigh P Brody,1,* Meliz Sahuri-Arisoylu,1,* James R Parkinson,1 Harry G Parkes,2 Po Wah So,3 Nabil Hajji,4 E Louise Thomas,1 Gary S Frost,5 Andrew D Miller,6,* Jimmy D Bell1,* 1Department of Life Sciences, Faculty of Science and Technology, University of Westminster, 2CR-UK Clinical MR Research Group, Institute of Cancer Research, Sutton, Surrey, 3Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 4Department of Medicine, Division of Experimental Medicine, Centre for Pharmacology & Therapeutics, Toxicology Unit, Imperial College London, 5Faculty of Medicine, Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6Institute of Pharmaceutical Science, King’s College London, London, UK *These authors contributed equally to this work Abstract: Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN. We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo. Keywords: lipid-based nanoparticles, liposomes

  10. Influence of drinking water containing Aloe vera (Aloe barbadensis Miller gel on growth performance, intestinal microflora, and humoral immune responses of broilers

    Directory of Open Access Journals (Sweden)

    Meisam Shokraneh

    2016-11-01

    Full Text Available Aim: The risk of bacteria resistance to specific antibiotics possibly by continuous subtherapeutical administration of antibiotic growth promoters (AGPs in poultry feed led to a ban on the use of AGP in poultry production. As a result of this ban, alternative substances for poultry growth promotion and disease prevention are being investigated, among which phytogenic and herbal products have received increased attention as natural additives because they have been accepted by consumers as natural additives. The effect of water supplementation of Aloe vera (AV as an AGP substitute on performance, intestinal microflora, and immune responses of broilers. Materials and Methods: The five experimental treatments were allocated to four replicates. The following treatments were applied (1 a basal broiler diet (C and normal drinking water, (2 0.5% AV gel in drinking water, (3 0.75% AV gel in drinking water, (4 1% AV gel in drinking water, and (5 diet C supplemented with flavophospholipol at 4.5 mg/kg and drinking normal water. Vaccines against influenza disease and sheep red blood cell (SRBC were administrated to immunological stimuli. The populations of Lactobacilli spp. and coliforms were enumerated in ileum. Results: Body weight of broilers supplemented with different levels of AV increased compared with control group (p<0.05. Birds supplemented with antibiotic had the best feed-to-gain ratio (F:G in different periods. Supplementation of 0.5% and 0.75% AV improved F:G entire experimental period compared with control group (p<0.05. Coliform bacteria were reduced in broilers supplemented with different levels of AV or antibiotic (p<0.05. The Lactobacilli spp. population in birds supplemented with 0.75%, 1% AV or antibiotic significantly was higher than other groups (p<0.05. Supplementation with 1% AV led to greater antibody titers against SRBC compared with other groups (p<0.05. Conclusion: These findings demonstrated a possibility of supplementing broiler drinking water with 1% AV gel as an alternative for AGP substitution.

  11. Phytohormone Signaling of the Resistance to Plum pox virus (PPV, Sharka Disease Induced by Almond (Prunus dulcis (Miller Webb Grafting to Peach (P. persica L. Batsch

    Directory of Open Access Journals (Sweden)

    Azam Nikbakht Dehkordi

    2018-05-01

    Full Text Available Plum pox virus (PPV, sharka is a limiting factor for peach production, and no natural sources of resistance have been described. Recent studies, however, have demonstrated that grafting the almond cultivar “Garrigues” onto the “GF305” peach infected with Dideron-type (PPV-D isolates progressively reduces disease symptoms and virus accumulation. Furthermore, grafting “Garrigues” onto “GF305” prior to PPV-D inoculation has been found to completely prevent virus infection, showing that resistance is constitutive and not induced by the virus. To unravel the phytohormone signaling of this mechanism, we analyzed the following phytohormones belonging to the principal hormone classes: the growth-related phytohormones cytokinin trans-zeatin (tZ and the gibberellins GA3 and GA4; and the stress-related phytohormones ethylene acid precursor 1-aminocyclopropane-1-carboxylic acid (ACC, abscisic acid (ABA, salicylic acid (SA, and jasmonic acid (JA. PPV inoculation produced a significant increase in GA3 and ABA in peach, and these imbalances were related to the presence of chlorosis symptoms. However, grafting “Garrigues” almond onto the PPV-inoculated “GF305” peach produced the opposite effect, reducing GA3 and ABA contents in parallel to the elimination of symptoms. Our results showed the significant implication of SA in this induced resistance in peach with an additional effect on tZ and JA concentrations. This SA-induced resistance based in the decrease in symptoms seems to be different from Systemic Acquired Resistance (SAR and Induced Systemic Resistance (ISR, which are based in other reactions producing necrosis. Further studies are necessary, however, to validate these results against PPV-D isolates in the more aggressive Marcus-type (PPV-M isolates.

  12. Effect of nickel monolayer deposition on the structural and electronic properties of the low miller indices of (bcc) iron: A DFT study

    International Nuclear Information System (INIS)

    Kwawu, Caroline R.; Tia, Richard; Adei, Evans; Dzade, Nelson Y.; Catlow, C. Richard A.; Leeuw, Nora H. de

    2017-01-01

    Highlights: • Thermodynamically, mono-layer deposition is exothermic on Fe (111) and (100) but endothermic on the Fe (110) facet. • The preferred adsorption site is the hollow site on all surface coverages except the 1 ML covered (110) surface, where the top site is most preferred. • Deposition leads to surface relaxation and no reconstruction, most profound on the stepped (111) surface, with the highest Ni-Fe interactions. • Work function of the bare (100), (110) and (111) surfaces were found to be 3.80 eV, 4.76 eV and 3.84 eV respectively. • Nickel monolayer deposition increases the work function on the (100) and (111) surfaces implying reduced corrosion tendencies. - Abstract: Metal clusters of both iron (Fe) and nickel (Ni) have been found in nature as active electro-catalytic sites, for example in the enzyme carbon mono-oxide dehydrogenase found in autotrophic organisms. Thus, surface modification of iron with nickel could improve the surface work function to enhance catalytic applications. The effects of surface modifications of iron by nickel on the structural and electronic properties have been studied using spin-polarised density functional theory calculations within the generalised gradient approximation. The thermodynamically preferred sites for Ni adsorption on the Fe (100), (110) and (111) surfaces have been studied at varying monolayer coverages (including 0.25 ML and 1 ML). The work function of the bare Fe surfaces is found to be of the order (100) ∼ (111) < (110) i.e. 3.80 eV ∼ 3.84 eV < 4.76 eV, which is consistent with earlier studies. The adsorption energies show that monolayer Ni deposition is thermodynamically favoured on the (100) and (111) surfaces, but not on the (110) surface. Expansion of the first interlayer spacing (d 12 ) of all three Fe surfaces is observed upon Ni deposition with the extent of expansion decreasing in the order (111) > (110) > (100), i.e. 6.78% > 5.76% > 1.99%. The extent of relaxation is magnified on the stepped (111) surface (by 1.09% to 30.88%), where the Ni coordination number is highest at 7 compared to 5 on the (100) facet and 4 on the (110) facet. The Ni deposition changes the work functions of the various surfaces due to charge reordering illustrated by charge density plots, where the work function is reduced only on the (110) surface by 0.04 eV, 0.16 eV and 0.17 eV at 1 ML, 0.5 ML and 0.25 ML respectively, with a concomitant increase in the surface dipole (polarity). This result implies enhanced electron activity and electrochemical reactivity on the most stable and therefore frequently occurring Ni-doped (110) facet compared to the clean (110) facet, which has implications for the development of improved Fe electro-catalysts (for example for CO 2 activation and reduction). These findings improve our understanding of the role of surface topology and stability on the extent of Ni interactions with Fe surfaces and the extent to which the Fe surface structures and properties are altered by the Ni deposition.

  13. Effect of nickel monolayer deposition on the structural and electronic properties of the low miller indices of (bcc) iron: A DFT study

    Energy Technology Data Exchange (ETDEWEB)

    Kwawu, Caroline R., E-mail: kwawucaroline@gmail.com [Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi (Ghana); Tia, Richard, E-mail: richtiagh@yahoo.com [Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi (Ghana); Adei, Evans [Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi (Ghana); Dzade, Nelson Y., E-mail: N.Y.Dzade@uu.nl [Department of Earth Sciences, Utrecht University, Princetonplein 9, 3584 CC, Utrecht (Netherlands); Catlow, C. Richard A. [Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ, London (United Kingdom); School of Chemistry, Cardiff University, Main Building, Park PI, Cardiff CF10 3AT (United Kingdom); Leeuw, Nora H. de, E-mail: DeLeeuwN@cardiff.ac.uk [Department of Earth Sciences, Utrecht University, Princetonplein 9, 3584 CC, Utrecht (Netherlands); Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ, London (United Kingdom); School of Chemistry, Cardiff University, Main Building, Park PI, Cardiff CF10 3AT (United Kingdom)

    2017-04-01

    Highlights: • Thermodynamically, mono-layer deposition is exothermic on Fe (111) and (100) but endothermic on the Fe (110) facet. • The preferred adsorption site is the hollow site on all surface coverages except the 1 ML covered (110) surface, where the top site is most preferred. • Deposition leads to surface relaxation and no reconstruction, most profound on the stepped (111) surface, with the highest Ni-Fe interactions. • Work function of the bare (100), (110) and (111) surfaces were found to be 3.80 eV, 4.76 eV and 3.84 eV respectively. • Nickel monolayer deposition increases the work function on the (100) and (111) surfaces implying reduced corrosion tendencies. - Abstract: Metal clusters of both iron (Fe) and nickel (Ni) have been found in nature as active electro-catalytic sites, for example in the enzyme carbon mono-oxide dehydrogenase found in autotrophic organisms. Thus, surface modification of iron with nickel could improve the surface work function to enhance catalytic applications. The effects of surface modifications of iron by nickel on the structural and electronic properties have been studied using spin-polarised density functional theory calculations within the generalised gradient approximation. The thermodynamically preferred sites for Ni adsorption on the Fe (100), (110) and (111) surfaces have been studied at varying monolayer coverages (including 0.25 ML and 1 ML). The work function of the bare Fe surfaces is found to be of the order (100) ∼ (111) < (110) i.e. 3.80 eV ∼ 3.84 eV < 4.76 eV, which is consistent with earlier studies. The adsorption energies show that monolayer Ni deposition is thermodynamically favoured on the (100) and (111) surfaces, but not on the (110) surface. Expansion of the first interlayer spacing (d{sub 12}) of all three Fe surfaces is observed upon Ni deposition with the extent of expansion decreasing in the order (111) > (110) > (100), i.e. 6.78% > 5.76% > 1.99%. The extent of relaxation is magnified on the stepped (111) surface (by 1.09% to 30.88%), where the Ni coordination number is highest at 7 compared to 5 on the (100) facet and 4 on the (110) facet. The Ni deposition changes the work functions of the various surfaces due to charge reordering illustrated by charge density plots, where the work function is reduced only on the (110) surface by 0.04 eV, 0.16 eV and 0.17 eV at 1 ML, 0.5 ML and 0.25 ML respectively, with a concomitant increase in the surface dipole (polarity). This result implies enhanced electron activity and electrochemical reactivity on the most stable and therefore frequently occurring Ni-doped (110) facet compared to the clean (110) facet, which has implications for the development of improved Fe electro-catalysts (for example for CO{sub 2} activation and reduction). These findings improve our understanding of the role of surface topology and stability on the extent of Ni interactions with Fe surfaces and the extent to which the Fe surface structures and properties are altered by the Ni deposition.

  14. [The fast of the emperor penguin (Aptenodytes patagonica J.F. Miller) on the Isle of the Possession (46 degrees 25' South, 51 degrees 045' East].

    Science.gov (United States)

    Barré, H

    1975-06-30

    During the fast, ponderal decrease and energy expenditure of captive King Penguins are minimal for the incubating adults, and maximal for the moulting birds who are producing their new plumage and whose insulation is reduced at that time. Whatever their conditions, the slope of the ponderal decrease curve is uniform before reaching a critical zone. On the other hand, it is independent of the seasons for the unemployed birds.

  15. HDL cholesterol, LDL receptor activity and response to dietary cholesterol *1 A reply to the letter of Cortese, Miller, Marenah and Lewis [2

    NARCIS (Netherlands)

    Beynen, A.C.; Katan, M.B.

    1984-01-01

    Variation in the concentration of cholesterol in blood plasma is partly accounted for by differences in diet, age, sex and genetic constitution. No correlation between plasma low density lipoprotein (LDL) cholesterol concentration and the activity of the LDL receptor in white blood cells could be

  16. Effects of 2,4-D and 4-CPA on yield and quality of the tomato, Lycopersicon esculentum Miller (Solanaceae)

    DEFF Research Database (Denmark)

    Gemici, Meliha; Türkyilmaz, B.; Tan, Kit

    2007-01-01

    Synthetic plant growth substances augment plant growth when applied at specific concentrations; they are also reported as without causing significant increases in the amount of internal plant hormones. Exceeding recommended dosages, however, affects yield and quality adversely. An experiment, to ...

  17. "Any Willing Provider" laws not preempted by Employee Retirement Income Security Act (ERISA). Kentucky Association of Health Plans, Inc. et. al. v. Miller, Commissioner, Kentucky Department of Insurance.

    Science.gov (United States)

    2004-01-01

    "Any Willing Provider" laws are not preempted by ERISA because they are state laws regulating insurance if they are (1) specifically directed toward entities engaged in insurance and (2) substantially affect the risk-pooling arrangement between the insurer and the insured. Thus, a state may prohibit health maintenance organizations (HMOs) from creating exclusive "provider networks" of doctors, hospitals and other health care providers by excluding other providers who are "willing and able" to comply with all the HMO's contractual terms if the law meets the new two-prong test established by the Supreme Court in this case. The Court made a "clean break" from using the McCarran-Ferguson Act factors for determining whether certain practices constitute "the business of insurance," when deciding when they regulate insurance for purposes of ERISA preemption.

  18. Optimality in Microwave-Assisted Drying of Aloe Vera ( Aloe barbadensis Miller) Gel using Response Surface Methodology and Artificial Neural Network Modeling

    Science.gov (United States)

    Das, Chandan; Das, Arijit; Kumar Golder, Animes

    2016-10-01

    The present work illustrates the Microwave-Assisted Drying (MWAD) characteristic of aloe vera gel combined with process optimization and artificial neural network modeling. The influence of microwave power (160-480 W), gel quantity (4-8 g) and drying time (1-9 min) on the moisture ratio was investigated. The drying of aloe gel exhibited typical diffusion-controlled characteristics with a predominant interaction between input power and drying time. Falling rate period was observed for the entire MWAD of aloe gel. Face-centered Central Composite Design (FCCD) developed a regression model to evaluate their effects on moisture ratio. The optimal MWAD conditions were established as microwave power of 227.9 W, sample amount of 4.47 g and 5.78 min drying time corresponding to the moisture ratio of 0.15. A computer-stimulated Artificial Neural Network (ANN) model was generated for mapping between process variables and the desired response. `Levenberg-Marquardt Back Propagation' algorithm with 3-5-1 architect gave the best prediction, and it showed a clear superiority over FCCD.

  19. Effect of Aloe vera (Aloe barbadensis Miller) on survivability, extent of proteolysis and ACE inhibition of potential probiotic cultures in fermented milk.

    Science.gov (United States)

    Basannavar, Santosh; Pothuraju, Ramesh; Sharma, Raj Kumar

    2014-10-01

    In the present investigation, the effect of Aloe vera gel powder on angiotensin-converting enzyme (ACE) inhibitory activity, extent of proteolysis during fermentation and survival of Lactobacillus casei NCDC19 during storage of fermented milk was studied. Among the different cultures screened for ACE inhibitory activity, Lactobacillus casei NCDC 19 exhibited the highest ACE inhibition (approx. 40%) as well as extent of proteolysis (0.37, Abs₃₄₀). In the presence of Aloe vera (0.5% and 1% w/v) an increase in extent of proteolysis (0.460 ± 0.047 and 0.480 ± 0.027) and percent ACE inhibitory activity (44.32 ± 2.83 and 47.52 ± 1.83) was observed in comparison to control. Aloe vera powder addition also led to an increase in viable counts (>11 log cfu mL⁻¹) of L. casei NCDC 19 in fermented milk during storage for 7 days and the counts were maintained in sufficiently higher numbers. The study suggests Aloe vera to be a good functional ingredient which can be further explored for different health attributes. © 2014 Society of Chemical Industry.

  20. Aloe vera (Aloe barbadensis Miller) supplemented probiotic lassi prevents Shigella infiltration from epithelial barrier into systemic blood flow in mice model.

    Science.gov (United States)

    Hussain, Shaik Abdul; Patil, Girdhari Ramdas; Reddi, Srinu; Yadav, Vidhu; Pothuraju, Ramesh; Singh, Ram Ran Bijoy; Kapila, Suman

    2017-01-01

    The aim of present work was to investigate preventive role of orally administered Aloe vera supplemented probiotic lassi (APL) on Shigella dysenteriae infection in mice. At the end of experimental period (2, 5 and 7 days of challenging), different organs such as spleen, liver, small intestine, large intestine, and peritoneal fluid were collected and assessed for Shigella colonization. Secretary IgA was estimated in intestinal fluid. Blood was collected in heparinized tubes for various haematological studies. Oral administration of APL showed a significant (p < 0.05) reduction in the Shigella counts (log cfu/mL) in all organs as compared to other treatment groups at different intervals after post feeding. Similarly, secretary IgA antibody levels (μg/mL) in intestinal fluid were significantly (p < 0.05) increased in case of APL fed mice. Further, feeding of APL also demonstrated a positive effect on different haematological parameters viz. Hb (gm %), RBC and WBC count. The results indicated the immunoprotective effects of APL against Shigella dysenteriae induced infection in mice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. New Times, New Heroes : Ambiguity, Socio-Political Issues and Post Modernism in Frank Miller's Graphic Novel The Dark Knight Returns

    OpenAIRE

    Axelsson, Jan

    2013-01-01

    Frank Miller’s The Dark Knight Returns is one of the first graphic novels to redraw the map for this kind of literature but perhaps first and foremost for the characteristics of superheroes and villains. It is a story which we have read before in the sense that Batman, the eternal crime fighter, chases his arch enemies Two Face and the Joker, but it is also a new story in which we meet an ambiguous and complex superhero. Batman has become an old man tormented by his past, in which his side ki...

  2. Mejora genética del almendro (Prunus dulcis Miller) por cruzamientos intervarietales : herencia de caracteres y selección / Federico Dicenta López-Higuera.

    OpenAIRE

    Dicenta Lopez-Higuera, Federico

    1991-01-01

    Tesis-Universidad de Murcia. Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. D 338. Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. D 335. Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M.-636.

  3. Exsolution of Iron-Titanium Oxides in Magnetite in Miller Range (MIL) 03346 Nakhlite: Evidence for Post Crystallization Reduction in the Nakhlite Cumulate Pile

    Science.gov (United States)

    Righter, Kevin; Keller, L. P.; Rahman, Z.; Christoffersen, R.

    2012-01-01

    MIL 03346 is one of the most mesostasis-rich nakhlites [1] and thought to have equilibrated at oxygen fugacities near the fayalite-magnetite-quartz oxygen (FMQ) buffer ([2,3]). Studies of FeTi oxides in nakhlites have led to additional constraints on their equilibration temperatures and fO2s [4,5,6,7]. Comparison of these results to fO2s calculated for shergottites indicates that nakhlites are among the most oxidized samples from the martian meteorite suite [2]. The mesostasis of MIL 03346 contains skeletal titanomagnetite. Several scientists noticed several years ago (e.g. [8]) that this titanomagnetite contains very fine oxidation-driven exsolution lamellae (Figure 1). However, the lamellae are so small that they cannot be characterized by electron microprobe analysis (EMPA). Here we select several areas for focused ion beam (FIB) extraction, prepare transmission electron microscopy (TEM) foils, and identify and analyze the lamellae using TEM at the Johnson Space Center (JSC). The resulting analyses are combined with previous work on nakhlites to interpret the thermal and oxidation history of this meteorite group.

  4. Dietary Sodium Modulation of Aldosterone Activation and Renal Function During the Progression of Experimental Heart Failure Miller: Dietary Sodium and Early Heart Failure

    Science.gov (United States)

    Miller, Wayne L.; Borgeson, Daniel D.; Grantham, J. Aaron; Luchner, Andreas; Redfield, Margaret M.; Burnett, John C.

    2015-01-01

    Aims Aldosterone activation is central to the sodium-fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the role of dietary sodium during the progression of experimental HF. Methods and Results Experimental HF was produced in a canine model by rapid right ventricular pacing which evolves from early mild HF to overt, severe HF. Dogs were fed one of three diets: 1) high sodium [250 mEq (5.8 grams) per day, n=6]; 2) standard sodium [58 mEq (1.3 grams) per day, n=6]; and 3) sodium restriction [11 mEq (0.25 grams) per day, n=6]. During the 38 day study hemodynamics, renal function, renin activity (PRA), and aldosterone were measured. Changes in hemodynamics at 38 days were similar in all three groups, as were changes in renal function. Aldosterone activation was demonstrated in all three groups, however, dietary sodium restriction, in contrast to high sodium, resulted in early (10 days) activation of PRA and aldosterone. High sodium demonstrated significant suppression of aldosterone activation over the course of HF progression. Conclusions Excessive dietary sodium restriction particularly in early stage HF results in early aldosterone activation, while normal and excess sodium intake are associated with delayed or suppressed activation. These findings warrant evaluation in humans to determine if dietary sodium manipulation, particularly during early stage HF, may have a significant impact on neuroendocrine disease progression. PMID:25823360

  5. Efecto de fertilización nitrogenada en la producción de biomasa y calidad de aceite esencial en Lippia alba (Miller, Pronto alivio.

    Directory of Open Access Journals (Sweden)

    Sánchez O. M.

    2004-04-01

    Full Text Available En el Campo Experimental de la Universidad Nacional de Colombia sede Palmira (CEUNP se realizó un ensayo para evaluar el efecto de la fertilización nitrogenada, aplicando dos fuentes (gallinaza y urea en dos niveles (50 y 100 kg/ha de nitrógeno y dos frecuencias de corte (dos y cuatro meses. En el lote experimental se situaron 15 parcelas, en un diseño de bloques completos al azar, con cinco tratamientos y tres repeticiones. Para el análisis de la información se utilizó el programa estadístico SAS. El máximo rendimiento de biomasa y aceites esenciales se obtuvo con la aplicación de 100 kg/ha de nitrógeno en forma de urea y la frecuencia de corte cada dos meses. Los niveles de extracción de Lippia alba en nitrógeno variaron entre 79.7 y 128.5; fósforo entre 24.5 y 30.5; potasio entre 114.6 y 138.8 y calcio entre 100 y 150 kg/ha. El aceite esencial estuvo compuesto mayoritariamente por carvona y limoneno. Palabras claves: Fertilización nitrogenada, Lippia alba, Rendimientos biomasa, aceites esenciales, pronto alivio. ABSTRACT Nitrogenous fertilization effects in the Lippia alba production and quality. In the Experimental Center of the National University of Colombia-Palmira (CEUNP a experiment was realized to evaluate the effect of the nitrogenous fertilization, using two sources (gallinaza and urea at two levels (50 and 100 kg/ha of nitrogen and two cutting frequencies (each two and four months. In the experimental area 15 plots were planted, in a randomized Complete Blocks design random (RCBD with five treatments and three repetitions to measure the following variables: production of fresh matter, content of dry matter, nutrients extraction and content of essential oils. The analysis of variance used the statistical program SAS. The maximum yield of biomass and essential was obtained oils combining the fertilization with 100 kg/ha of nitrogen as urea and the cutting frequency every of two months. The levels of nutrients extraction of Lippia alba varied between 79.7 and 128.5 kg/ha of nitrogen, 24.5 and 30.5 kg/ha of phosphorus, 114.6 and 138.8 Kg/ha of potassium and between 100 y 150 kg/ha of Calcium. The phytochemical analyses showed that the essential oil was mainly composed by carvona and limoneno. Key words: Nitrogenous Fertilization, Lippia alba, yields, biomass, essential oils.

  6. Organic Analysis in Miller Range 090657 and Buckley Island 10933 CR2 Chondrites: Part 1 In-Situ Observation of Carbonaceous Material

    Science.gov (United States)

    Cao, T.; Nakamura-Messenger, K.; Berger, E. L.; Burton, A. S.; Messenger, S.; Clemett, S. J.

    2016-01-01

    Primitive carbonaceous chondrites contain a wide variety of organic material, ranging from soluble discrete molecules to insoluble unstructured kerogen-like component as well as structured nano-globules of macromolecular carbon. The relationship between the soluble organic molecules, macromolecular organic material, and host minerals are poorly understood. Due to the differences in extractability of soluble and insoluble organic materials, the analysis methods for each differ and are often performed independently. The combination of soluble and insoluble analyses, when performed concurrently, can provide a wider understanding on spatial distribution, and elemental, structural and isotopic composition of organic material in primitive meteorites. Furthermore, they can provide broader perspective on how extraterrestrial organic ma-terials potentially contributed to the synthesis of life's essential compounds such as amino acids, sugar acids, activated phosphates and nucleobases.

  7. Comments on Janie Rees-Miller's "A Critical Appraisal of Learning Training: Theoretical Bases and Teaching Implications." Two Readers React... [and] The Author Responds...

    Science.gov (United States)

    Chamot, Anna Uhl; And Others

    1994-01-01

    Two researchers respond to a previous "TESOL Quarterly" article that assessed the state of the art of research and classroom applications of learning strategies, and the author of the article responds to those comments. (71 references) (JL)

  8. Tabla Local de Rendimiento para Ciprés (Cupressus lusitanica Miller Válida para los Alrededores de Medellín

    Directory of Open Access Journals (Sweden)

    Illencik Zani Guillermo

    1973-12-01

    Full Text Available La presente tabla de rendimiento del ciprés (Cupressus lusitanica, confeccionada a base de muestras tomadas en los cipresales del Valle de Aburrá y de los montes colindantes, es de carácter local. A pesar de la escasez, la débil distribución y la heterogeneidad del levantamiento de las parcelas de muestra disponibles, esta obra es bastante aceptable para llenar interinamente un vacío existente en nuestra literatura forestal económica. La tabla de rendimiento presenta la composición y el desarrollo de un cipresal normal (ideal, puro y coetáneo de una hectárea, en dependencia de las condiciones estacionales y de la edad. Sirve de medida en la clasificación de cualquier cipresal de los amplios alrededores de Medellín. Se suponen aclareos quinquenales, moderados, de 9 a 15%, en el rodal principal. El conocimiento de la edad es una condición cardinal para el liso de una tabla de rendimiento. Sin embargo, conociendo el área basal o la masa y la altura dominante o medida del rodal, pueden sacarse conclusiones referentes a la edad física o económica del mismo.

  9. Isolation and identification of phosphate solubilizing bacteria able to enhance the growth and aloin-A biosynthesis of Aloe barbadensis Miller.

    Science.gov (United States)

    Gupta, Mamta; Kiran, Shashi; Gulati, Arvind; Singh, Bikram; Tewari, Rupinder

    2012-06-20

    The effect of four phosphate solubilizing bacteria (PSB) was studied on growth and aloin-A content of Aloe barbadensis in soil containing tricalcium phosphate (TCP). PSB were identified based on 16S rRNA gene sequencing as Pseudomonas synxantha, Burkholderia gladioli, Enterobacter hormaechei and Serratia marcescens. These PSB solubilized 25-340 μg ml(-1) of TCP into the liquid phase. The treatment of plants with individual PSB or mixture of these increased soil available P, P uptake in plants and plant growth. The increase in aloin-A content due to higher plant biomass and unit biomass production was 673%, 294%, 276%, 119% and 108% in plants treated with a PSB consortium, P. synxantha, S. marcescens, B. gladioli, and E. hormaechei in TCP amended soil, respectively. Copyright © 2012 Elsevier GmbH. All rights reserved.

  10. Origin and shape evolution of core-shell nanoparticles in Au-Pd: from few atoms to high Miller index facets

    Energy Technology Data Exchange (ETDEWEB)

    Bhattarai, Nabraj; Casillas, Gilberto; Khanal, Subarna; Velazquez Salazar, J. Jesus; Ponce, Arturo; Jose-Yacaman, Miguel, E-mail: miguel.yacaman@utsa.edu [University of Texas at San Antonio, Department of Physics and Astronomy (United States)

    2013-06-15

    Au-Pd core-shell nanocubes and triangular nanoparticles were systematically synthesized from a few Pd layers up to fully grown morphologies by a modified seed-mediated growth method. The shape evolution of Au-Pd core-shell nanoparticles from single crystal and singly twinned seed to final concave nanocube and triangular plates are presented at atomic level by Cs-corrected scanning transmission electron microscopy (STEM). The growth mechanism of both morphologies was studied throughout different sizes. It was found that the concave nanocubes grew from octahedral Au seeds due to fast growth along Left-Pointing-Angle-Bracket 111 Right-Pointing-Angle-Bracket directions; while the triangular nanoparticles grew from singly twinned Au seeds, growing twice as fast in Left-Pointing-Angle-Bracket 110 Right-Pointing-Angle-Bracket directions along the twin boundary; compared to the Left-Pointing-Angle-Bracket 111 Right-Pointing-Angle-Bracket direction perpendicular to the twin boundary. Both the concave nanocubes and triangular nanoparticles presented high index facet (HIF) surfaces that will increase the catalytic activity of different reactions.

  11. WATER TEMPERATURE and other data from COLUMBUS CANADA, NOAA Ship MILLER FREEMAN and other platforms from 1989-03-28 to 1989-08-31 (NODC Accession 9000093)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contain data from Nine Seas III cruises conducted using many different ships. The bathythermograph (XBT) data was collected between March 28 and...

  12. Low dose γ-irradiation as a suitable solution for chestnut (Castanea sativa Miller) conservation: effects on sugars, fatty acids, and tocopherols.

    Science.gov (United States)

    Fernandes, Ângela; Antonio, Amilcar L; Barros, Lillian; Barreira, João C M; Bento, Albino; Botelho, M Luisa; Ferreira, Isabel C F R

    2011-09-28

    Along with dehydration, the development of insects and microorganisms is the major drawback in chestnut conservation. Irradiation has been regaining interest as an alternative technology to increase food product shelf life. In the present work, the effects of low dose gamma irradiation on the sugar, fatty acid, and tocopherol composition of chestnuts stored at 4 °C for different storage periods (0, 30, and 60 days) was evaluated. The irradiations were performed in a 60Co experimental equipment, for 1 h (0.27±0.04 kGy) and 2 h (0.54±0.04 kGy). Changes in sugars and tocopherols were determined by high performance liquid chromatography coupled to refraction index and fluorescence detections, respectively, while changes in fatty acids were analyzed by gas-chromatography coupled to flame ionization detection. Regarding sugar composition, storage time proved to have a higher effect than irradiation treatment. Fructose and glucose increased after storage, with the corresponding decrease of sucrose. Otherwise, the tocopherol content was lower in nonirradiated samples, without a significant influence of storage. Saturated, monounsaturated, and polyunsaturated fatty acids levels were not affected, either by storage or irradiation. Nevertheless, some individual fatty acid concentrations were influenced by one of two factors, such as the increase of palmitic acid in irradiated samples or the decrease of oleic acid after 60 days of storage. Overall, the assayed irradiation doses seem to be a promising alternative treatment to increase chestnut shelf life, without affecting the profile and composition in important nutrients.

  13. Pathology Survey on a Captive-Bred Colony of the Mexican Goodeid, Nearly Extinct in the Wild, Zoogoneticus tequila (Webb & Miller 1998

    Directory of Open Access Journals (Sweden)

    Alessio Arbuatti

    2013-01-01

    Full Text Available The Mexican Goodeid, Zoogoneticus tequila, is considered nearly extinct in the wild and it is maintained in captivity by the nonprofit international “Goodeid Working Group.” The unique Italian colony has produced about 180 fish so far. The observable diseases were registered and some fish were submitted, immediately after spontaneous death, to necroscopic and histopathologic exams. Encountered diseases included the following: 7 cases of scoliosis (2 males and 5 females; 2 fish with a similar congenital deviation of ocular axis; 1 adult male with left corneal opacity, presumably of traumatic origin; 1 female fish with a large subocular fluid-filled sac, histologically referable to a lymphatic cyst, similarly to the eye sacs of a Goldfish variety (Carassius auratus called bubble eye; and 1 female fish with recurrent abdominal distension consequent to distal bowel dilation and thinning, associated with complete mucosal atrophy, and comparable to intestinal pseudo-obstruction syndromes described in humans and various animal species. The absence of infectious or parasitic diseases, as well as the low incidence of diseases potentially related to environmental alterations or nutritional disorders such as spinal deformities, suggests the adequacy of breeding management techniques of Z. tequila for its conservation and reintroduction in to the original habitat in the near future.

  14. Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial.

    Science.gov (United States)

    Tenore, Gian Carlo; Caruso, Domenico; Buonomo, Giuseppe; D'Urso, Emanuela; D'Avino, Maria; Campiglia, Pietro; Marinelli, Luciana; Novellino, Ettore

    2017-05-01

    Recent human studies have evaluated the effect of daily apple consumption on plasma cholesterol level, which is recognized as an important risk factor for cardiovascular disease (CVD). Nevertheless, slightly significant effects have been generally registered although consuming more than two apples a day for several weeks. This study describes the influence of daily consumption of Annurca apples on the cholesterol levels of mildly hypercholesterolaemic healthy subjects. A monocentric, randomized, parallel-group, placebo-controlled, 4-month study was conducted. The subjects (n = 250) were randomly assigned to five treatment groups (each one of 50 subjects: 28 men and 22 women). Four groups were administered one apple per day among the following: Red Delicious, Granny Smith, Fuji, Golden Delicious. The fifth group was asked to consume two Annurca apples per day, since the weight of this cultivar is on average half that of the commercial ones considered in this study. Comparing results, Annurca led to the most significant outcome, allowing a reduction in total and low-density lipoprotein cholesterol levels by 8.3% and 14.5%, respectively, and an increase in high-density lipoprotein cholesterol levels by 15.2% (all P apple as a useful tool to contribute to the prevention of CVD risk through normal diet. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  15. Est pictura po︠sis, est po︠sis pictura. Carl Grassi (1767-1814) maastikud / Kadi Polli ; tõlk. Hanna Miller

    Index Scriptorium Estoniae

    Polli, Kadi, 1973-

    2007-01-01

    Kirjanik ja kunstnik C. Grass sündis 8. oktoobril Liivimaal, suri 22. juulil Roomas. Elust ja kunstiloomingust, reisidest, sidemetest kaasaegsete vaimuinimestega, töödest Tartu Ülikooli kunstikogus

  16. 78 FR 13213 - Regional Reliability Standard PRC-006-NPCC-1- Automatic Underfrequency Load Shedding

    Science.gov (United States)

    2013-02-27

    ... Energy Manchester Street, Inc., Elwood Energy, LLC, Kincaid Generation, LLC, and Fairless Energy, LLC. II... Registry, there are 2 planning coordinators and 135 generator owners within the United States portion of... indicates that 5 small entities are registered as generator owners in the United States portion of the NPCC...

  17. Helpers in Distress: Preventing Secondary Trauma

    Science.gov (United States)

    Whitfield, Natasha; Kanter, Deborah

    2014-01-01

    Those in close contact with trauma survivors are themselves at risk for trauma (e.g., Bride, 2007; Figley, 1995). Family, friends, and professionals who bear witness to the emotional retelling and re-enacting of traumatic events can experience what is called "secondary trauma" (Elwood, Mott, Lohr, & Galovski, 2011). The literature…

  18. 78 FR 23636 - Advisory Committee on Minority Veterans, Notice of Meeting

    Science.gov (United States)

    2013-04-19

    ... the VA Regional Office, 2122 West Taylor Street, Chicago, IL;. On April 24, from 9 a.m. to 11 a.m., at the Abraham Lincoln National Cemetery, 20953 West Hoff Road, Elwood Illinois; from 2 p.m. to 3 p.m... conduct an exit briefing with leadership from the VA Hospital, Chicago Regional Office, and Abraham...

  19. Life history and population dynamics of an estuarine amphipod, Eriopisa chilkensis Chilton (Gammaridae)

    Digital Repository Service at National Institute of Oceanography (India)

    Aravind, N.P.; Sheeba, P.; Nair, K.K.C.; Achuthankutty, C.T.

    of Experimental Marine Biology and Ecology 248, 207-223. Dick, J.T.A., Bailey, R.J.E., Elwood, R.W., 2002. Maternal care in the rockpool amphipod Apherusa jurinei, developmental and environmental cues. Animal Behaviour 63, 707- 713. El. Wakeel, S.K., Riley, J...

  20. 75 FR 39529 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-09

    ..., President (Qualifying Individual), Theodore Green, Stockholder, Application Type: New OFF & NVO License Benchmark Worldwide Logistics, Inc. dba Star Ocean Lines (OFF & NVO), 29400 South Route 53, Elwood, IL 60421..., President, Application Type: New OTI & NVO License CTC Logistics (L.A.) Inc. (NVO), 5250 W. Century Blvd...

  1. Diversity within the Joint Team: Understanding the Different Operational Perspectives of the Army and Air Force

    Science.gov (United States)

    2012-12-06

    Tactical Air Command (TAC), led by two-star General Elwood “Pete” Quesada, and the Strategic Air Command (SAC), headed by four-star General George Kenny ...Lieutenant General Tom Kelly, interrupted, “This isn’t going to work. Air Power can’t be decisive!”158 In response, the Air Force’s Vice Chief of Staff

  2. IN-A-BOX

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 2. Claude Elwood Shannon. Priti Shankar. Article-in-a-Box Volume 7 Issue 2 February 2002 pp 2-3 ... Author Affiliations. Priti Shankar1. Department of Computer Science & Automation, Indian Institute of Science, Bangalore 560 012, India.

  3. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 2. Claude Elwood Shannon. Priti Shankar. Article-in-a-Box Volume 7 Issue 2 February 2002 pp 2-3. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/007/02/0002-0003. Author Affiliations.

  4. CONTINUOUS THUNDER: The Challenge of Artillery Support for the Close Battle.

    Science.gov (United States)

    1985-12-02

    great World War II 9th Air Force Commander, Major General Elwood P. " Pete " Quesada: - Close-in air ground cooperation is the difficult thing, the...Coordination -- A Time For Change!" Unpublished paper, U.S. Army War College, 1984. Rickett , Brigadier J.F. "Surviving the Air and Artillery

  5. Chemical and physical properties of aloe vera (Aloe barbadensis Miller gel stored after high hydrostatic pressure processing Propriedades químicas e físicas do gel de aloe vera (Aloe barbadensis Miller armazenado após processamento sob alta pressão hidrostática

    Directory of Open Access Journals (Sweden)

    Karina Di Scala

    2013-03-01

    Full Text Available The aim of this study was to evaluate the influence of high hydrostatic pressure (150, 250, 350, 450, and 550 MPa, applied for 5 minutes, on antioxidant capacity, total phenolic content, color, firmness, rehydration ratio, and water holding capacity of aloe vera gel stored for 60 days at 4 °C. The analyzed properties of the pressurized gel showed significant changes after the storage period. The highest value of total phenolic content was found at 550 MPa. However, a decrease in the antioxidant capacity was observed for all pressurized gel samples when compared to the control sample (p O objetivo deste estudo foi avaliar o efeito da aplicação de altas pressões hidrostáticas (150, 250, 350, 450 e 550 MPa aplicadas durante 5 minutos sobre a atividade antioxidante, concentração de polifenóis totais, cor, firmeza, taxa de reidratação e capacidade de retenção de água do gel de aloe vera armazenado durante 60 dias a 4 °C. As propriedades analisadas do gel pressurizado mostraram mudanças significativas depois de armazenadas. Para pressões de 550 Mpa, registrou-se o maior aumento de polifenóis totais. No entanto, observou-se uma diminuição da capacidade antioxidante em todas as amostras, em comparação com a amostra não tratada (p < 0,05. As alterações de cor foram menores para pressões entre 150 e 250 MPa. A aplicação de altas pressões hidrostáticas diminuiu a firmeza do gel, registrando-se o menor valor para 150 MPa (p < 0,05. Por outro lado, o tratamento sem pressão mostrou uma maior perda de firmeza, indicando que o tratamento por altas pressões conserva esta propriedade. A aplicação de altas pressões evidenciou modificações da matriz do alimento, avaliadas como taxa de reidratação e capacidade de retenção de água.

  6. Les accidents de cyclomoteurs: mécanismes lésionnels | Mnif | Pan ...

    African Journals Online (AJOL)

    cytochrome c oxidase deficiency". Few psychiatric disorders have been defined that are associated with Leigh syndrome. The objective of this work is to study relations between mitochondrial dysfunction and psychiatric disorders. It was a 20 year ...

  7. Matriarhaalne edasikestmine / Jüri Laulik

    Index Scriptorium Estoniae

    Laulik, Jüri, 1959-

    2008-01-01

    12. PÖFFi filmidest: Bernd Böclichi "Kuu ja teised armukesed" ("Der Mond und andere Leibhaber", Saksamaa), Mike Leigh' "Happy-Go-Lucky" (Suurbritannia), Kirill Serebrennikovi "Jüripäev" ("Jurjev den", Venemaa)

  8. Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment.

    NARCIS (Netherlands)

    Koopman, W.J.H.; Verkaart, S.A.J.; Emst-de Vries, S.E. van; Grefte, S.; Smeitink, J.A.M.; Nijtmans, L.G.J.; Willems, P.H.G.M.

    2008-01-01

    Deficiency of mitochondrial NADH:ubiquinone oxidoreductase (complex I), is associated with a variety of clinical phenotypes such as Leigh syndrome, encephalomyopathy and cardiomyopathy. Circumstantial evidence suggests that increased reactive oxygen species (ROS) levels contribute to the

  9. HIV epidemic drivers in South Africa: A model-based evaluation of ...

    African Journals Online (AJOL)

    HIV epidemic drivers in South Africa: A model-based evaluation of factors accounting for inter-provincial differences in HIV prevalence and incidence trends. Leigh F. Johnson, Rob E. Dorrington, Haroon Moolla ...

  10. Observations on placentome diameters in gestating West African ...

    African Journals Online (AJOL)

    ADEYEYE

    2015-09-09

    /10.4314/sokjvs.v13i3.4. Observations on placentome diameters in gestating West. African dwarf does experimentally infected with Trypanosoma brucei. OO Leigh. Department of Veterinary Surgery and Reproduction, ...

  11. Naised mõrvarite jälil / Kaisa Karu

    Index Scriptorium Estoniae

    Karu, Kaisa

    2010-01-01

    Kanal 2 ekraanil kaks naispeaosalistega krimisarja : uurija Lilly Rush (Kathryn Morris) sarjas "Jahtunud jälg" (USA, 2003-... ) ja Brenda Leigh Johnson (Kyra Sedgwick) seriaalis "Vahelevõtja" (USA, 2005-... )

  12. An Investigation of the Potential of 31-Phosphorus Nuclear Magnetic Resonance Spectroscopy to Predict Radiation Sensitivity

    Science.gov (United States)

    1988-01-01

    adenine triphosphate (NTP). The PME resonance originates primarily from phosphorylethanolamine (PE) and phosphorylcholine (PC). The phosphate diester (PDE...1985. 17. Gyulai, L., Bolinger, L., Leigh, J. S., Jr., Barlow, C., and Chance, B. Phosphorylethanolamine -the major constituent of the

  13. Crack propagation studies and bond coat properties in thermal ...

    Indian Academy of Sciences (India)

    Unknown

    1989). Yet TBCs represent an attractive material to enhance the high temperature limits of the superalloy engine components notwithstanding its limitations to spalling by oxidation of the bond coat (Miller and Lowell. 1982; Liebert and Miller 1984; Miller and Berndt 1984;. DeMasi et al 1989; Brindley and Miller 1990; Kokini.

  14. «Тропик Рака» г. Миллера. К вопросу о жанре

    OpenAIRE

    Петров, Д.

    2006-01-01

    The article is focused on H. Miller's mode of reality transformation into the world of fiction. Thus the relation between Miller-the-author and Miller-the-character appears to be a key question in "Tropic of Cancer". Consequently the problem of fictional/non-fictional correlation is touched upon. H. Miller is both autobiography (non-fiction) and novel (fiction) oriented writer.

  15. The 2009 Physics Nobel Prize

    Directory of Open Access Journals (Sweden)

    José Maria Filardo Bassalo

    2010-09-01

    Full Text Available In this article we will talk about the Nobel Prize in Physics 2009, granted to the physicists north-americans: Charles Kuen Kao (born in China, for its discovery of the process of transmission of light in optical fibers; and Willard Sterling Boyle (born in Canada and George Elwood Smith, for the invention of an imaging semiconductor circuit – the CCD sensor.

  16. Infoajastu teerajajad / Henn Käämbre

    Index Scriptorium Estoniae

    Käämbre, Henn, 1935-

    2009-01-01

    Nobeli füüsikapreemia said tänavu kolm füüsikut panuse eest infotehnoloogilisse revolutsiooni: hiinlasest Briti-USA füüsik Charles Kuen Kao optiliste kaablite arendamisel ning kaks tema kolleegi, Kanada-USA füüsik Willard Sterling Boyle ja USA füüsik George Elwood Smith sensoritüübi CCD leiutamisel

  17. Army - Air Force Cooperation: Looking Backward to Move Forward

    Science.gov (United States)

    2016-05-26

    the land battle.1 Today’s disagreements focus more on control of unmanned reconnaissance drones , providing air base defense and conducting counter... History demonstrates that ever-changing strategic environments require a military willing to transform and adapt.6 The Army, in its 2014 operating...cooperation between the Army and the Air Force. While the and Missions, by Richard I. Wolf (Washington, DC: Office of Air Force History , 1987), v. 5 Elwood

  18. Lower Neurocognitive Function in U-2 Pilots: Relationship to White Matter Hyperintensities

    Science.gov (United States)

    2014-07-09

    subjects. Nonetheless, normative scores on the MicroCog have been established for age and education level,22 and overall, MicroCog-derived scores show good...age- and education -corrected Micro- Cog subtests demonstrated a significant difference between U2Ps and AFPs on reason/calculation, mem- ory...Rehfeldt JD, Ryder JA. Note on comparability of Micro- Cog test forms. Percept Mot Skills 2001;93:825–828. 24. Elwood RW. MicroCog: assessment of cognitive

  19. Jupiter's Spot Seen Glowing - Scientists Get First Look at Weather Inside the Solar System's Biggest Storm

    Science.gov (United States)

    2010-03-01

    Structure and Composition of Jupiter's Great Red Spot from High-Resolution Thermal Imaging", by L. Fletcher et al.). The team is composed of Leigh N. Fletcher and P. G. J. Irwin (University of Oxford, UK), G. S. Orton, P. Yanamandra-Fisher, and B. M. Fisher (Jet Propulsion Laboratory, California Institute of Technology, USA), O. Mousis (Observatoire de Besançon, France, and University of Arizona, Tucson, USA), P. D. Parrish (University of Edinburgh, UK), L. Vanzi (Pontificia Universidad Catolica de Chile, Santiago, Chile), T. Fujiyoshi and T. Fuse (Subaru Telescope, National Astronomical Observatory of Japan, Hawaii, USA), A.A. Simon-Miller (NASA/Goddard Spaceflight Center, Greenbelt, Maryland, USA), E. Edkins (University of California, Santa Barbara, USA), T.L. Hayward (Gemini Observatory, La Serena, Chile), and J. De Buizer (SOFIA - USRA, NASA Ames Research Center, Moffet Field, CA 94035, USA). Leigh Fletcher was working at JPL during the study. ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is

  20. In Vitro Antioxidant Effects of Aloe barbadensis Miller Extracts and the Potential Role of These Extracts as Antidiabetic and Antilipidemic Agents on Streptozotocin-Induced Type 2 Diabetic Model Rats

    Directory of Open Access Journals (Sweden)

    Md. Ibrahim Khalil

    2012-11-01

    Full Text Available In this study, the total phenolic and flavonoid contents, the 2,2-diphenyl-1-picryl hydrazyl (DPPH radical scavenging ability and the ferric reducing power (FRAP of Aloe vera were measured to determine the antioxidant activity of this species. The in vivo antidiabetic effects of the plant were also investigated using streptozotocin-induced type 2 diabetic model rats that were divided into five groups based on the treatment received: (1 water (WC; (2 glibenclamide; (3 concentrated gel extract (Gel-C; (4 ethanol (80% gel extract (Gel-Et; and (5 ethanol (80% skin extract of Aloe vera (Skin-Et. Skin-Et, which contained the highest level of total phenolics (62.37 ± 1.34 mggallic acid/kg and flavonoids (20.83 ± 0.77 mg/kg, exhibited the highest scavenging activity (85.01 ± 0.52% and the greatest reducing power (185.98 ± 0.41 µM, indicating that the skin contained the highest level of antioxidants. The oral consumption of Gel-Et for 4 weeks a caused significant reduction in the fasting serum glucose levels of the rats. The rats in the Gel-C-, Gel-Et- and Skin-Et-treated groups experienced a reduction in their total cholesterol levels by 11%, 17% and 25%, respectively and a reduction in their LDL cholesterol levels by 45%, 3% and 69%, respectively. The in vivo experimental antioxidant parameter MDA is strongly correlated with the in vitro antioxidant parameters of flavonoids and polyphenols, namely the DPPH and FRAP values (r = 0.94, 0.92, 0.93, 0.90, thus confirming the antioxidant potential of the Aloe vera extracts.

  1. Cloud amount/frequency, NITRATE and other data from NOAA Ship MILLER FREEMAN in the NE Pacific from 1991-04-02 to 1991-10-05 (NODC Accession 9200030)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Conductivity, Temperature and Depth (CTD) and other data were collected in NE Pacific (limit-180) as part of Fisheries-Oceanography Cooperative Investigations...

  2. Book review of Insect Symbiosis. Volume 2. Bourtzis, K.A. and Miller, T.A. editros. 2006 CRC Press, Taylor and Francis Group, Boca Raton, FL, 276 pp. ISBN 0-8493-1286-8

    International Nuclear Information System (INIS)

    Hoy, M.A.

    2007-01-01

    There are several definitions of symbiosis, but in this book it involves an association where one organism (the symbiont) lives within or on the body of another organism (the host), regardless of the actual effect on the host. Some symbioses are mutualistic, some parasitic, and some involve commensalism, in which one partner derives some benefit without either harming or benefiting the other. This is the second volume in this exciting and rapidly advancing topic by these editors. The first volume was published in 2003 and during the intervening three years additional data have been produced that make this book a useful addition to your library. The first book provided chapters that provided an overview of insect symbiosis, discussions of the primary aphid symbiont Buchnera and other aphid symbionts, symbiosis in tsetse, symbionts in the weevil Sitophilus , the possible use of paratransgenic symbionts of Rhodnius prolixis to prevent disease transmission, bark beetle and fungal symbiosis, symbionts of tephritid fruit flies, symbionts affecting termite behavior, an overview of microsporidia as symbionts (parasites?) of insects, an overview of a newly discovered bacterium that causes sex-ratio distortion in insects and mites (from the Bacteroides group), symbionts that selectively kill male insects, and several chapters on the ubiquitous endosymbiont Wolbachia

  3. OLD SCHOOL LINGUISTICS MADE NEW— REVIEW OF Contemporary Linguistics: An Introduction. 5th ed. By William O’Grady, John Archibald, Mark Arnoff, and Janie Rees-Miller. New York: Bedford/St. Martin’s, 2005. Pp. xxvi + 684.

    Directory of Open Access Journals (Sweden)

    Chris Wen-chao Li

    2008-06-01

    Full Text Available Amidst the recent explosion of interest in linguistic science and the subsequent publication of large numbers of introductory works on the subject, O'Grady et al.'s Contemporary Linguistics (5th ed. stands out as a solid general purpose primer directed at an academic audience. Written by some eighteen contributors specializing in each of the seventeen branches of linguistics covered, topics are judiciously chosen while drawing on current scholarship and integrating different theoretical persuasions, without losing sight of the book's target readership. The result is an up-to-date text balanced in its treatment of subject matter and perspectives--a work that lives up to its moniker of "Contemporary" Linguistics.

  4. Efecto bioinsecticida del extracto etanólico de las semillas de Annona cherimolia Miller “chirimoya” Y A. muricata Linneaus “guanábana” sobre larvas del IV estadio de Anopheles sp.

    Directory of Open Access Journals (Sweden)

    Miguel Bobadilla Álvarez

    2013-06-01

    Full Text Available En vista del incremento de la resistencia a los insecticidas químicos frente al control de mosquitos vectores de enfermedades metaxénicas, es que se viene realizando la búsqueda de métodos alternativos, utilizando extractos de plantas con actividad larvicida debido a su capacidad de biodegradación generando menor daño ambiental. Bajo esta premisa, el objetivo del presente trabajo fue evaluar la mortalidad de larvas del IV estadio de Anopheles sp. mediante el extracto etanólico de las semillas de A. cherimolia (E1 y A. muricata (E2. Los mayores porcentajes de mortalidad, corregidos por la fórmula de Abbott, fueron de 100% a las 24 horas de exposición a la concentración de 0,8 y 0,12 ml/100 mL en E1 y E2, respectivamente, observándose un mayor efecto tóxico larvario a favor de E2 sobre E1 en 4,58% de mortalidad. El análisis probit mostró un patrón de respuesta heterogéneo de las larvas a las concentraciones letales al 50% (CL50 y al 90% (CL90 a lo largo de todos los tiempos de evaluación y una mayor homogeneidad a los tiempos letales al 50% (TL50 y al 90% (TL90 a medida que aumentaban las concentraciones de los extractos. Asimismo, la forma de las rectas de regresión muestran individuos larvarios con diferentes susceptibilidades a los extractos, lo que establece diferentes poblaciones o genotipos intervinientes. El trabajo permitió demostrar el efecto larvicida de ambas semillas y subraya la necesidad de realizar mayores ensayos in vitro como alternativa al control de insectos de importancia en salud pública.

  5. WATER TEMPERATURE and other data from NOAA Ship MILLER FREEMAN, NOAA Ship ALBATROSS IV and other platforms from 1987-08-09 to 1988-10-12 (NODC Accession 8800290)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains nine sets of data. The cruises were conducted using many different ships. The bathythermograph (XBT) data was collected between August 9,...

  6. Conservación de fresa (fragaria x ananassa duch cv. camarosa) mediante la aplicación de revestimientos comestibles de gel mucilaginoso de penca de sábila (aloe barbadensis miller)

    OpenAIRE

    Restrepo Fernández, Jorge Iván

    2009-01-01

    Los métodos de conservación que permiten mantener los atributos de calidad con características sensoriales de frescura resultan ser vitales para un mercado de consumidores que demanda día a día alimentos mínimamente procesados. La tecnología emergente de aplicación de recubrimientos comestibles (RC) sobre frutas, como sistema de conservación, ha venido ganando mucho desarrollo y posicionamiento debido a su relativo bajo costo frente a otras de mayor aplicación tecnológica como las atmósferas ...

  7. Cetacean line-transect survey conducted in the eastern Bering Sea shelf by Alaska Fisheries Science Center, National Marine Mammal Laboratory from NOAA Ship Miller Freeman from 1999-07-07 to 2004-06-30 (NCEI Accession 0131862)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Visual surveys for cetaceans were conducted on the eastern Bering Sea shelf along transect lines, in association with the AFSC’s echo integration trawl surveys for...

  8. WATER TEMPERATURE and other data from NOAA Ship MILLER FREEMAN, USCGC POLAR SEA and other platforms from 1989-01-05 to 1989-11-12 (NODC Accession 9000016)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains data from cruises that were conducted using many different ships. The bathythermograph (XBT) data was collected between January 5 and...

  9. Hydrology and numerical simulation of groundwater movement and heat transport in Snake Valley and surrounding areas, Juab, Miller, and Beaver Counties, Utah, and White Pine and Lincoln Counties, Nevada

    Science.gov (United States)

    Masbruch, Melissa D.; Gardner, Philip M.; Brooks, Lynette E.

    2014-01-01

    Snake Valley and surrounding areas, along the Utah-Nevada state border, are part of the Great Basin carbonate and alluvial aquifer system. The groundwater system in the study area consists of water in unconsolidated deposits in basins and water in consolidated rock underlying the basins and in the adjacent mountain blocks. Most recharge occurs from precipitation on the mountain blocks and most discharge occurs from the lower altitude basin-fill deposits mainly as evapotranspiration, springflow, and well withdrawals.The Snake Valley area regional groundwater system was simulated using a three-dimensional model incorporating both groundwater flow and heat transport. The model was constructed with MODFLOW-2000, a version of the U.S. Geological Survey’s groundwater flow model, and MT3DMS, a transport model that simulates advection, dispersion, and chemical reactions of solutes or heat in groundwater systems. Observations of groundwater discharge by evapotranspiration, springflow, mountain stream base flow, and well withdrawals; groundwater-level altitudes; and groundwater temperatures were used to calibrate the model. Parameter values estimated by regression analyses were reasonable and within the range of expected values.This study represents one of the first regional modeling efforts to include calibration to groundwater temperature data. The inclusion of temperature observations reduced parameter uncertainty, in some cases quite significantly, over using just water-level altitude and discharge observations. Of the 39 parameters used to simulate horizontal hydraulic conductivity, uncertainty on 11 of these parameters was reduced to one order of magnitude or less. Other significant reductions in parameter uncertainty occurred in parameters representing the vertical anisotropy ratio, drain and river conductance, recharge rates, and well withdrawal rates.The model provides a good representation of the groundwater system. Simulated water-level altitudes range over almost 2,000 meters (m); 98 percent of the simulated values of water-level altitudes in wells are within 30 m of observed water-level altitudes, and 58 percent of them are within 12 m. Nineteen of 20 simulated discharges are within 30 percent of observed discharge. Eighty-one percent of the simulated values of groundwater temperatures in wells are within 2 degrees Celsius (°C) of the observed values, and 55 percent of them are within 0.75 °C. The numerical model represents a more robust quantification of groundwater budget components than previous studies because the model integrates all components of the groundwater budget. The model also incorporates new data including (1) a detailed hydrogeologic framework, and (2) more observations, including several new water-level altitudes throughout the study area, several new measurements of spring discharge within Snake Valley which had not previously been monitored, and groundwater temperature data. Uncertainty in the estimates of subsurface flow are less than those of previous studies because the model balanced recharge and discharge across the entire simulated area, not just in each hydrographic area, and because of the large dataset of observations (water-level altitudes, discharge, and temperatures) used to calibrate the model and the resulting transmissivity distribution.Groundwater recharge from precipitation and unconsumed irrigation in Snake Valley is 160,000 acre-feet per year (acre-ft/yr), which is within the range of previous estimates. Subsurface inflow from southern Spring Valley to southern Snake Valley is 13,000 acre-ft/yr and is within the range of previous estimates; subsurface inflow from Spring Valley to Snake Valley north of the Snake Range, however, is only 2,200 acre-ft/yr, which is much less than has been previously estimated. Groundwater discharge from groundwater evapotranspiration and springs is 100,000 acre-ft/yr, and discharge to mountain streams is 3,300 acre-ft/yr; these are within the range of previous estimates. Current well withdrawals are 28,000 acre-ft/yr. Subsurface outflow from Snake Valley moves into Pine Valley (2,000 acre-ft/yr), Wah Wah Valley (23 acre-ft/yr), Tule Valley (33,000 acre-ft/yr), Fish Springs Flat (790 acre-ft/yr), and outside of the study area towards Great Salt Lake Desert (8,400 acre-ft/yr); these outflows, totaling about 44,000 acre-ft/yr, are within the range of previous estimates.The subsurface flow amounts indicate the degree of connectivity between hydrographic areas within the study area. The simulated transmissivity and locations of natural discharge, however, provide a better estimate of the effect of groundwater withdrawals on groundwater resources than does the amount and direction of subsurface flow between hydrographic areas. The distribution of simulated transmissivity throughout the study area includes many areas of high transmissivity within and between hydrographic areas. Increased well withdrawals within these high transmissivity areas will likely affect a large part of the study area, resulting in declining groundwater levels, as well as leading to a decrease in natural discharge to springs and evapotranspiration.

  10. LA PRACTICA CLÍNICA DEL TRABAJO SOCIAL CON LAS PERSONAS MAYORES. BEAVER MARIÓN L MILLER DONJNTERVENCIÓN PRIMARIA, SECUNDARIA, TERCIARIA. PAIDÓS, SEGUNDA EDICIÓN, ESPAÑA 1988,457 PÁGINAS.

    Directory of Open Access Journals (Sweden)

    Yesica Alexandra Rodríguez

    2012-08-01

    Full Text Available El texto brinda elementos clave para el desempeño del trabajo social con personas mayores. Los autores presentan una caracterización detallada de este tipo de población, dan a conocer formas practicas de intervención, tomando como referencia estudios de casos ya tratados y colocando al trabajador social en la posibilidad de observar aquellos papeles que pueda jugar en el momento de acceder esta población.

  11. WATER TEMPERATURE and other data from NOAA Ship RESEARCHER, NOAA Ship MILLER FREEMAN and other platforms in the Gulf of Mexico, NW Atlantic and NE Pacific from 1987-01-08 to 1987-07-01 (NODC Accession 8700254)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using XBT and BT casts from NOAA Ship RESEARCHER and other platforms in the Gulf of Mexico and Northwest Atlantic Ocean from...

  12. Miller Catherine, Al-Wer Enam, Caubet Dominique et Watson Janet C. E. (dirs, Arabic in the City, Issues in dialect contact and language variation, Londres/New York, Routledge, 2007, 354 p.

    Directory of Open Access Journals (Sweden)

    Julien Dufour

    2010-01-01

    Full Text Available Cet ouvrage collectif entreprend de présenter la recherche actuelle sur les changements linguistiques dans les milieux urbains arabophones. On avait grand besoin d’un tel état des lieux, et cette publication constitue une référence utile dans un domaine d’une importance capitale pour comprendre les évolutions qui traversent la langue et les sociétés arabes. Un groupe de chercheurs, confirmés ou plus jeunes, a longuement collaboré pour arriver à ce résultat, en particulier lors d’un atelier-co...

  13. Metabolic rescue in pluripotent cells from patients with mtDNA disease.

    Science.gov (United States)

    Ma, Hong; Folmes, Clifford D L; Wu, Jun; Morey, Robert; Mora-Castilla, Sergio; Ocampo, Alejandro; Ma, Li; Poulton, Joanna; Wang, Xinjian; Ahmed, Riffat; Kang, Eunju; Lee, Yeonmi; Hayama, Tomonari; Li, Ying; Van Dyken, Crystal; Gutierrez, Nuria Marti; Tippner-Hedges, Rebecca; Koski, Amy; Mitalipov, Nargiz; Amato, Paula; Wolf, Don P; Huang, Taosheng; Terzic, Andre; Laurent, Louise C; Izpisua Belmonte, Juan Carlos; Mitalipov, Shoukhrat

    2015-08-13

    Mitochondria have a major role in energy production via oxidative phosphorylation, which is dependent on the expression of critical genes encoded by mitochondrial (mt)DNA. Mutations in mtDNA can cause fatal or severely debilitating disorders with limited treatment options. Clinical manifestations vary based on mutation type and heteroplasmy (that is, the relative levels of mutant and wild-type mtDNA within each cell). Here we generated genetically corrected pluripotent stem cells (PSCs) from patients with mtDNA disease. Multiple induced pluripotent stem (iPS) cell lines were derived from patients with common heteroplasmic mutations including 3243A>G, causing mitochondrial encephalomyopathy and stroke-like episodes (MELAS), and 8993T>G and 13513G>A, implicated in Leigh syndrome. Isogenic MELAS and Leigh syndrome iPS cell lines were generated containing exclusively wild-type or mutant mtDNA through spontaneous segregation of heteroplasmic mtDNA in proliferating fibroblasts. Furthermore, somatic cell nuclear transfer (SCNT) enabled replacement of mutant mtDNA from homoplasmic 8993T>G fibroblasts to generate corrected Leigh-NT1 PSCs. Although Leigh-NT1 PSCs contained donor oocyte wild-type mtDNA (human haplotype D4a) that differed from Leigh syndrome patient haplotype (F1a) at a total of 47 nucleotide sites, Leigh-NT1 cells displayed transcriptomic profiles similar to those in embryo-derived PSCs carrying wild-type mtDNA, indicative of normal nuclear-to-mitochondrial interactions. Moreover, genetically rescued patient PSCs displayed normal metabolic function compared to impaired oxygen consumption and ATP production observed in mutant cells. We conclude that both reprogramming approaches offer complementary strategies for derivation of PSCs containing exclusively wild-type mtDNA, through spontaneous segregation of heteroplasmic mtDNA in individual iPS cell lines or mitochondrial replacement by SCNT in homoplasmic mtDNA-based disease.

  14. Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects

    DEFF Research Database (Denmark)

    Koene, S; Rodenburg, R J; van der Knaap, M S

    2012-01-01

    . Age at presentation may vary, but is generally within the first year of life. The most prevalent symptoms include hypotonia, nystagmus, respiratory abnormalities, pyramidal signs, dystonia, psychomotor retardation or regression, failure to thrive, and feeding problems. Characteristic symptoms include...... brainstem involvement, optic atrophy and Leigh syndrome on MRI, either or not in combination with internal organ involvement and lactic acidemia. Virtually all children ultimately develop Leigh syndrome or leukoencephalopathy. Twenty-five percent of the patients died before the age of six months, more than...

  15. AcEST: DK945338 [AcEST

    Lifescience Database Archive (English)

    Full Text Available hul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David...n, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST

  16. AcEST: DK947581 [AcEST

    Lifescience Database Archive (English)

    Full Text Available e: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, a...L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gappe

  17. AcEST: BP919457 [AcEST

    Lifescience Database Archive (English)

    Full Text Available chul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and Davi...ejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and P

  18. AcEST: DK944153 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David ..., Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST a

  19. AcEST: DK947778 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997)...chaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and PSI-BLAST: a

  20. AcEST: DK946346 [AcEST

    Lifescience Database Archive (English)

    Full Text Available chul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and Davi...en, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST

  1. AcEST: DK946405 [AcEST

    Lifescience Database Archive (English)

    Full Text Available : Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, an.... Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped

  2. AcEST: DK962276 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and ...Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped B

  3. AcEST: DK943983 [AcEST

    Lifescience Database Archive (English)

    Full Text Available e: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, a...L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gappe

  4. AcEST: DK945792 [AcEST

    Lifescience Database Archive (English)

    Full Text Available e: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, a...L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gappe

  5. AcEST: DK943569 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and ...Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped B

  6. AcEST: BP918928 [AcEST

    Lifescience Database Archive (English)

    Full Text Available nce: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller,...adden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BL

  7. AcEST: DK944304 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David ..., Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST a

  8. AcEST: DK946539 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ltschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and D...adden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BL

  9. AcEST: BP921502 [AcEST

    Lifescience Database Archive (English)

    Full Text Available nce: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller,...adden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BL

  10. AcEST: BP915145 [AcEST

    Lifescience Database Archive (English)

    Full Text Available homas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),..., Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and PSI-BLAST: a new gen

  11. AcEST: DK947501 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997...Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and PSI-BLAST: a

  12. AcEST: DK945167 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and... Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped

  13. AcEST: DK943583 [AcEST

    Lifescience Database Archive (English)

    Full Text Available , Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J....Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and

  14. AcEST: DK945145 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lip...andro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and PSI

  15. AcEST: DK944429 [AcEST

    Lifescience Database Archive (English)

    Full Text Available homas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),...haffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and PSI-BLAST: a n

  16. Strategies for getting through labor

    Science.gov (United States)

    ... to stay comfortable. Keep your mind busy. Bring books, photo albums, games, or other things that will ... Flood P, Rolins MD. Anesthesia for obstetrics. In: Miller RD, ed. Miller's ... PA: Elsevier Saunders; 2015:chap 77. Mertz MJ, Earl ...

  17. Mustvalge ja verine koomiksiklassik / Mart Kalvet

    Index Scriptorium Estoniae

    Kalvet, Mart, 1975-

    2010-01-01

    Arvustus: Miller, Frank. Sin City. [1. osa]., Karm hüvastijätt : [koomiks / tõlkija Holger Loodus ; Sin City logo: Steve Miller ; eestikeelse väljaande kujundus: Marko Russiver. Tallinn] : Eesti Päevaleht, [2009

  18. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest 2 Pac "Pac's Life", "Kitsune Maison", Kenny Garrett "Beyond the Wall", Marcus Miller "Power: The Essential Marcus Miller", Clipse "Hell Hath No Fury", Moby "Go ئ The Very Best Of", Ian Archer "Magnetic North"

  19. Crack propagation studies and bond coat properties in thermal ...

    Indian Academy of Sciences (India)

    Unknown

    1982; Liebert and Miller 1984; Miller and Berndt 1984;. DeMasi et al 1989; Brindley and Miller 1990; Kokini et al 1997). NiCrAlY or NiCoCrAlY type metallic under- coat generally ..... Lelait K, Alperine S, Diot C and Marvel M 1989 Mater. Sci. Engg. A120–121 475. Liebert C H and Miller R A 1984 Ind. Eng. Chem. Prod. Res.

  20. System of Systems Engineering and Integration Process for Network Transport Assessment

    Science.gov (United States)

    2016-09-01

    Source: Miller (2004, 22). The OSI model is critical to understanding the behavior of applications over the network . As different applications use...architecture, the OSI layers need to be understood and modeled to sufficient detail to characterize the behavior of the networks and applications. B...3 Figure 3. Converged Network Architecture. Source: Miller (2004, 433). ..................8 Figure 4. OSI Layer. Source: Miller (2004

  1. Gingival Prosthesis; An Alternative to Surgery in Multiple Site ...

    African Journals Online (AJOL)

    Y is a 26 year old male; Nigerian medical student who presented with a case IV localized gingival recession of the right mandibular central and lateral incisors. Miller's class II gingival recession on the lower left central and Miller's class III gingival recession on the lower left lateral incisor. The Miller's class IV localized ...

  2. Exactly Embedded Wavefunction Methods for Characterizing Nitrogen Reduction Catalysis

    Science.gov (United States)

    2015-01-15

    two in preparation: • “A simple, exact density-functional-theory embedding scheme,” F. R. Manby, M. Stella , J. D. Goodpaster, and T. F. Miller III, J...and Kaito Miyamoto (U. Bristol / Toyota Co.). Miller, FA9550-11-1-0288 Final Report - 5 [1] F. R. Manby, M. Stella , J. D. Goodpaster, and T. F. Miller

  3. Ethical Realism: A Guide to Action?

    Science.gov (United States)

    Matkin, Gary

    2008-01-01

    This article presents the author's response to Gary Miller's essay entitled "Ethical Realism and Continuing Education." In his essay, Dr. Miller has provided a valuable opportunity to reflect on the practice of continuing education (CE) leadership. Dr. Miller reviews six principles that are encapsulated in the concept of ethical realism, but are…

  4. Sliding Charge Density Waves and Related Problems.

    Science.gov (United States)

    1987-03-31

    An exact solution Leigh Sneddon .5 The arie Fisher School ot Phisics . Branaets Lniierirt. Walhamn, A fas suetuserts t)22.74 (Received 13 March 1984...semiconductor. While careful 0 qualitative tests still remain to be performed, these results are clearly qualitatively in agreement with the "catch 22". 2’.! 5

  5. Browse Author Index

    African Journals Online (AJOL)

    Yuan · Hsieh, Yu-Hsiang · Hull, JC · Hung, TI · Hussey, G ... Jani, I · Janse van Rensburg, E · Jarvis, JN · Jeenah, FY · John, M A · John, M-A · Johnson, Leigh F. Johnson, LF · Jones, L · Jones, PS · Jonsson, G · Joska, J

  6. Case Report Hypothyroidism could be the only manifestation of ...

    African Journals Online (AJOL)

    Mitochondrial DNA-associated Leigh syndrome is a part of a continuum of progressive neurodegenerative disorders caused by abnormalities of mitochondrial energy generation. Mitochondrial T8993C and T8993G mutations account for 10–20% of these cases. T8993C is generally associated with milder phenotype than ...

  7. ORIGINAL ARTICLES Estimation of adult antiretroviral treatment ...

    African Journals Online (AJOL)

    ORIGINAL ARTICLES. 661. Estimation of adult antiretroviral treatment coverage in. South Africa. Muhammad Aarif Adam, Leigh F Johnson. Death notification statistics confirm that AIDS is dramatically affecting mortality in South Africa.1 Demographic and epidemiological models suggest that antiretroviral treatment is.

  8. Adult Education and Social Sustainability: Harnessing the "Red Queen Effect"

    Science.gov (United States)

    Easton, Peter

    2007-01-01

    In 1973, the evolutionary biologist Leigh Van Valen of the University of Chicago devised what he called the "Red Queen Effect" to describe the growth and development of species. It stipulated that an evolutionary system must continue to develop just to maintain its fitness relative to others evolving in its environment. The literary reference is…

  9. An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase

    NARCIS (Netherlands)

    Hinttala, R.; Sasarman, F.; Nishimura, T.; Antonicka, H.; Brunel-Guitton, C.; Schwartzentruber, J.; Fahiminiya, S.; Majewski, J.; Faubert, D.; Ostergaard, E.; Smeitink, J.; Shoubridge, E.A.

    2015-01-01

    Protein synthesis in mitochondria is initiated by formylmethionyl-tRNA(Met) (fMet-tRNA(Met)), which requires the activity of the enzyme MTFMT to formylate the methionyl group. We investigated the molecular consequences of mutations in MTFMT in patients with Leigh syndrome or cardiomyopathy. All

  10. Supermodellid läbi aegade / Kaarin Kivirähk

    Index Scriptorium Estoniae

    Kivirähk, Kaarin

    2014-01-01

    20. sajandi supermodellid: Anita Colby, Lisa Fonssagrives, Dorian Leigh, Suzy Parker, Dovima, Jean Shrimpton, Twiggy, Jerry Hall, Iman, Lauren Hutton, Marisa Berenson, Janice Dickinson, Cindy Crafword, Paulina Porizkova, Gia Carangi, Elle Macpherson, Linda Evangelista, Naomi Campbell, Gisele Bündchen, Kate Moss, Carmen Kass

  11. 78 FR 13211 - Commercial Acquisition; Extension of Suspension and Debarment Exclusions, Grants and Cooperative...

    Science.gov (United States)

    2013-02-27

    ... Acquisition; Extension of Suspension and Debarment Exclusions, Grants and Cooperative Agreements AGENCY... tiers of procurement and non-procurement actions under all grants and cooperative agreements. The... CONTACT: Leigh Pomponio, NASA, Office of Procurement, Contract Management Division (Suite 5G84); (202) 358...

  12. The Impact of Maternal Deafness on Cradling Laterality with Deaf and Hearing Infants

    Science.gov (United States)

    Sieratzki, Jechil S.; Woll, Bencie

    2004-01-01

    A recent article in the "Journal of Deaf Studies and Deaf Education" (Leigh, Brice, & Meadow-Orlans, 2004) explored attachment between deaf mothers and their 18-month-old children and reported relationship patterns similar to those for hearing dyads. The study reported here explores a marker of early mother-child relationships: cradling…

  13. Filmimaailma aplaus realismile : kolmas festivalikiri Cannes'ist, kus filmiprogramm on ületanud ekvaatori / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2002-01-01

    Kolmest seni huvitavamast filmist : inglase Mike Leigh' "Kõik või ei midagi", Michiganist pärit dokumentalisti Michael Moore'i ameeriklaste vägivaldsust uuriv "Keeglimäng enne Columbine'i", iraanlase Abbas Kiarostami "10" ja Kanada armeenlase Atom Egoyani "Ararat"

  14. Genetics Home Reference: MEGDEL syndrome

    Science.gov (United States)

    ... improve by early childhood; and episodes of abnormally high amounts of lactic acid in the blood (lactic acidosis). The life expectancy of individuals ... deafness, encephalopathy, and Leigh-like syndrome (MEGDEL association) in four ... feature: proper classification and nomenclature. J Inherit Metab Dis. 2013 Nov; ...

  15. A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome

    DEFF Research Database (Denmark)

    Duno, Morten; Wibrand, Flemming; Baggesen, Kirsten

    2013-01-01

    The archetypal NARP syndrome is almost exclusively associated with the m.8993T>C/G mutation in the sixth subunit of the mitochondrial ATP synthase, whereas other mutations in the MT-ATP6 gene primarily associate with Leigh syndrome or Leber's hereditary optic neuropathy (LHON). We report a novel ...

  16. Pollutant Source Tracking (PST) Technical Guidance

    Science.gov (United States)

    2011-12-01

    James A.Water, Leigh A.Burgonyne, David E.A. Catcheside, Winnie Dejonghe, Natalie Leys, Karolien Vanbroekhoven, Priyabrata Pattnaik and Duane Graves...Belshaw, G.W. Canters , E.C. de Waal, U. Weser, B.K. Burgess, and B. Salvato. 2002. Mass fractionation processes of transition metal isotopes. Earth and

  17. The burden of disease attributable to sexually transmitted infections ...

    African Journals Online (AJOL)

    The burden of disease attributable to sexually transmitted infections in South Africa in 2000. Leigh Johnson, Debbie Bradshaw, Rob Dorrington. Abstract. Objectives. To estimate the burden of disease attributable to sexually transmitted infections (STis) in South Africa, to identify the factors contributing to this burden, and to ...

  18. Biotin deficiency in the rat as a model for reduced pyruvate carboxylase activity

    NARCIS (Netherlands)

    Schrijver, Jacobus

    1978-01-01

    The investigations described in this thesis are a contribution to the study of Leigh's disease (Subacute Necrotizing Encephalomyelopathy, SNE). SNE resembles in neuropathology Wernicke's encephalopathy, which is caused by thiamine deficiency. The scope and the purpose of the present study is given

  19. Anthropological significance of dermatoglyphic trait variation: an ...

    African Journals Online (AJOL)

    Heredity, 23: 53-58. Hajn V., Gasiorowski A., 1999. Quantitative values on fingers and palms in Czech and. Polish populations. Biologica, 37: 107- 115. Henneberg M.J., Lambert K.M., Leigh C.M., 1997. Fingerprint homoplasy: Koalas and humans. Natural Science. Holt S.B., 1968. The genetics of dermal ridges. Thomas ...

  20. biochemical and molecular diagnosis of glutaric aciduria type 1

    African Journals Online (AJOL)

    2001-12-02

    Dec 2, 2001 ... actively in sports. On clinical examination, the abnormal movements were found to be consistent with choreoathetosis, and radiological examination .... Edwards M.A.. Gray R.G.F.. Crawley P. and Green. A. Glutaticaciduriatype l misdiagnosed as Leigh"senecphalopathy and cerebral palsy. Dev. Med. Child.

  1. Staff Views of the Importance of Relationships for Knowledge Development: Is Training by Specialists a Waste of Money?

    Science.gov (United States)

    Bradshaw, Jill; Goldbart, Juliet

    2013-01-01

    Background: The provision of skilled support is dependent on staff knowledge and understanding (Beadle-Brown J., Beecham J., Mansell J., Baumker T., Leigh J., Whelton R. & Richardson L, unpublished data). Influencing staff knowledge and understanding is an important component of interventions. Materials and Methods: Fourteen individual…

  2. Kuu filmid / toimetanud Maria Ulfsak-Šeripova

    Index Scriptorium Estoniae

    2011-01-01

    Aki Kaurismäki film "Le Havre" (Soome-Prantsusmaa-Saksamaa 2011) kinos Sõprus, Julia Leigh debüütfilm "Uinuv kaunitar" Coca-Cola Plazas (Austraalia 2011) ja režissöör Cyril Tuschi dokumentaalfilm "Hodorkovski" (Saksamaa 2011) Artise kinos

  3. Exploring Gender Norms through the "Colour Blind" Initiative

    Science.gov (United States)

    Niblett, Blair; Potvin, Leigh

    2010-01-01

    Recently, the authors have been collecting data for a research project that explores secondary school boys' perceptions of masculinity. They spent a week in Leigh's grade 11 philosophy class discussing gender while observing and video recording students' perception for analysis. In their research, they used Colour Blind as a vehicle for unearthing…

  4. The Right Time: Building the Learning Community Movement

    Science.gov (United States)

    Mutnick, Deborah

    2015-01-01

    The author argues that the current conjuncture is a kairotic moment for their own learning community program as well as the national movement to support the development of learning communities in universities and colleges and the array of pedagogical approaches associated with them. With Barbara Leigh Smith (2013), they recognize a link between…

  5. Transfigurations : Violence, Death and Masculinity in American Cinema

    NARCIS (Netherlands)

    Grønstad, Asbjørn

    2008-01-01

    Bij veel mensen en vooral filmliefhebbers is het geweld in Amerikaanse cinema er met de paplepel ingegoten: van Anthony Perkins die Janet Leigh aan stukken rijt in een van de meest beruchte douchescenes, via de meesterwerken uit de jaren zeventig van Martin Scorsese, Sam Peckinpah en Francis Ford

  6. Cytokeratin expression in human fetal tongue and buccal mucosa

    Indian Academy of Sciences (India)

    Unknown

    unusually complex pattern of expression of cytokeratin poly- peptides and vimentin; Differentiation 40 207–214. Markey A C, Lane E B, Churchill L J, MacDonald M and Leigh. I M 1991 Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia; Invest. Dermatol. 97 763–770. Moll R, Franke W W, Schiller D L, ...

  7. Author Details

    African Journals Online (AJOL)

    Wilson, Amy-Leigh. Vol 50, No 4 (2015) - Articles Digestive efficiency of indigenous and invasive avian species fed fruit of invasive alien plants in South Africa Abstract · Vol 50, No 4 (2015) - Articles Digestive parameters and energy assimilation of Cape porcupine on economically important crops. Abstract. ISSN: 2224- ...

  8. Resilient poultry management for women in Kenya

    International Development Research Centre (IDRC) Digital Library (Canada)

    team of Kenyan and Canadian researchers has been engaged in a farmer-led action research project since 2011, working with smallholder farmers (54 groups) in Makueni, Machakos and Tharaka-Nithi counties. Group members prioritized the farming practices they wanted. By Leigh Brownhill, Zipporah Bukania, Kimberly ...

  9. 77 FR 5308 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2012-02-02

    ... LABELLE JULIE A LEE HYANGLY LEE PETER WAI LING LEE YAT HUNG LELAND JACQUELINE........ LEMOS MICHAEL LERVIK ANNE SOPHIE LORANGE LEWICKI PAWEL M LIN HSIAO-CHUAN....... LIPPER NAOMI ISHIDO LOMP CHANA MIRIAM... YVONNE ROSE SHIOMI MAKOTO SHONHAN ROSS LEIGH SHOSTAK LISA CLARE SIM ANDREW YUN WEN SIMS CHARLES R SIMS...

  10. Fulltext PDF

    Indian Academy of Sciences (India)

    ShaoFei Wu

    2017-06-07

    Jun 7, 2017 ... 2005), economy, food security and human health. (Devereux 2007; Bond et al. 2008; Pederson et al. 2009; Leigh et al. 2014). Particularly, the ADFEs, ... change and fast urbanization in these two areas, the ADFEs have occurred more frequently in recent years (Li and Ye 2015). Hence, separate consider-.

  11. Joint pattern of seasonal hydrological droughts and floods ...

    Indian Academy of Sciences (India)

    ShaoFei Wu

    2017-06-07

    Jun 7, 2017 ... 2005), economy, food security and human health. (Devereux 2007; Bond et al. 2008; Pederson et al. 2009; Leigh et al. 2014). Particularly, the ADFEs, ... change and fast urbanization in these two areas, the ADFEs have occurred more frequently in recent years (Li and Ye 2015). Hence, separate consider-.

  12. L'élevage de la poule indigène, gage de résilience pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    3 juin 2016 ... Woman holding a chicken on her farm. Leigh Brownhill, Zipporah Bukania, Kimberly Bothi, Erick Mungube, Lutta Muhammad et Esther Njuguna. La recherche montre qua la poule indigène peut contribuer de façon stratégique à la résilience dans les zones semi-arides du Kenya. Des chercheurs du Kenya ...

  13. Interrelationships Between Landscape Art and Geography in Latin America: First Response to a Challenge.

    Science.gov (United States)

    Martinson, Tom L.

    Interrelationships between geography and art are explored and ways of integrating an appreciation of landscape art in Latin America into geography instruction are suggested. That geographers have long recognized the usefulness of landscape painting in the study of places is exemplified by the remark by geographer John Leighly in 1937 that "art…

  14. Berlinale art-house'i killukesi / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    2008-01-01

    Berliini 58. filmifestivali filmidest : USA režissööri Errol Morrise dokfilm "Tavaprotseduur" ("Standard Operating Procedure"), mehhiklase Fernando Eimbcke mängufilm "Tahoe järv" ("Lake Tahoe"), aserbaidžaani päritolu vene režissööri Anna Melikjani "Merineitsi" ("Russalka") ja inglase Mike Leigh' "Muretu" ("Happy-Go-Lucky")

  15. Conolly, R.B., Ankley, G.T., Cheng, WY., Mayo, M.L., Miller, D.H., Perkins, E.J., Villeneuve, D.L., and Watanable, K.H. (2017). Quantitative adverse outcome pathways and their application ot predictive toxicology. Environ. Sci. Technol. 51, 4661–4672

    Data.gov (United States)

    U.S. Environmental Protection Agency — A publised mansucript describing a quantitative adverse outcome pathway (qAOP) and its relevance to risk assessment. This dataset is not publicly accessible because:...

  16. Statement of Dr. Marilyn L. Miller, Immediate Past President, American Association of School Librarians, a Division of the American Library Association, before the Subcommittee on Education, Arts, and Humanities, Senate Labor and Human Resources Committee on Reauthorization of Chapter 2, Education Consolidation and Improvement Act, July 16, 1987.

    Science.gov (United States)

    Miller, Marilyn L.

    1988-01-01

    This statement in support of Education Consolidation Improvement Act reauthorization discusses six topics related to school libraries: (1) purpose of school libraries; (2) research supporting need for school libraries; (3) current status; (4) funding realities; (5) deteriorating book collections; and (6) impact of federal aid. An American Library…

  17. Análisis de la evolución del marketing 1.0, al marketing 3.0 y propuesta de aplicación en la marca Miller de la compañía Cervecería Nacional en el sector de la ciudad de Guayaquil.

    OpenAIRE

    Fuentes Vera, Sheyla Lisbeth; Vera Huacón, Andy Arisendy

    2015-01-01

    La evolución que se ha dado en el marketing, ha dejado atrás varias estrategias publicitarias usadas normalmente, enfocándose en el uso del marketing 3.0. Este trabajo de investigación propone dos estrategias de marketing social: una campaña publicitaria para el cuidado y protección del medio ambiente y una campaña publicitaria para la salud y ayuda a personas con enfermedades catastróficas. The evolution that has taken place in marketing, has left behind several advertising strategies use...

  18. Currents, backscatter, attenuation, conductivity, temperature, sigma-theta, and pressure data from moorings deployed from the SAMANTHA MILLER and the RV CONNECTICUT on the Hudson Shelf Valley, North Atlantic Ocean from the from April 5, 2006 to June 21, 2006 (NODC Accession 0066107)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Field experiments have been carried out to understand the transport of sediments and associated contaminants in the Hudson Shelf Valley, offshore of New York. The...

  19. Exactly Embedded Density Functional Theory: A New Paradigm for the First-principles Modeling of Reactions in Complex Systems

    Science.gov (United States)

    2014-10-14

    Physics, (08 2010): 84103. doi: 10.1063/1.3474575 Frederick R. Manby, Martina Stella , Jason D. Goodpaster, Thomas F. Miller. A Simple, Exact Density...Manby FR, Stella M, Goodpaster JD, Miller TF. ‘A simple, exact density-functional-theory embedding scheme.’ J. Chem. Theory Comput., 8 (2012) 2564. 5...J. Chem. Phys., 137, 224113, (2012). [13] F. R. Manby, M. Stella , J. D. Goodpaster, and T. F. Miller, III, A simple, exact density-functional theory

  20. The Guardian. Volume 9, Number 2, Fall 2007

    Science.gov (United States)

    2007-01-01

    service. My favorite TV commercial is the one produced by Miller Brewing Company. The narrator talks about how Miller helps local communities...respond following natural disasters. Bottlers in a local community just outside the disaster area immediately stop bottling beer , and instead put water...been awake for about a week) thanks Miller for its public service. He then says, “But guys, every once in awhile, you could put beer in a few of the