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Sample records for left jimmie johnson

  1. Jimmy, Mauritz, Choo ja Hennes / Aavo Kokk

    Index Scriptorium Estoniae

    Kokk, Aavo, 1964-

    2009-01-01

    Rõivapood H&M müüs kõrvuti oma kaubaga Jimmy Choo luksustooteid, mis maksid kümme korda vähem kui Jimmy Choo enda poodides. See esindab viimase kümnendi olulisimat trendi - kõrgmoodi püütakse muuta massikaubaks ja seda tootvaid ettevõtteid väga suureks

  2. Wiki-Jimmy käivitab mootori / Reet Alas

    Index Scriptorium Estoniae

    Alas, Reet

    2007-01-01

    Internetientsüklopeedia Wikipedia autor Jimmy Donal "Jimbo" Wales kavatseb peatselt käiku lasta uue otsingumootori Search Wikia, millest peaks saama tõsine konkurent praegustele juhtivatele Interneti otsimootoritele Google ja Yahoo. Lisa: Jimmy Wales

  3. Jimmy Carter and the Rhetoric of Charisma.

    Science.gov (United States)

    Campbell, J. Louis, III

    1979-01-01

    Analyzes Jimmy Carter's success in the 1976 presidential primaries in terms of his rhetorical style based on Max Weber's concept of charisma and Ernest Bormann's theory of fantasy and rhetorical vision. The combination of Carter's charismatic message and the country's social fantasies produced his election. (JMF)

  4. Kolonizatsija Palestinõ prepjatstvujet miru / Jimmy Carter

    Index Scriptorium Estoniae

    Carter, Jimmy

    2006-01-01

    Iisraeli poliitika vastuolulisus, Palestiina koloniseerimine takistab rahulepingu sõlmimist, olenemata sellest, kes Palestiina riiki parajasti juhib. USA ekspresident Jimmy Carteri hinnang protsessidele regioonis

  5. Jimmy Carter: The Rhetoric of Private and Civic Piety.

    Science.gov (United States)

    Erickson, Keith V.

    1980-01-01

    Discusses Jimmy Carter's use of religious-political discourse in the 1976 presidential campaign. Concludes that his speeches reaffirmed our civic piety and faith in America, communicated trustworthiness, served as a source of identification with evangelicals and religionists, and generated media attention. (JMF)

  6. Message from Jimmy Smits: La Vida Real PSA (:20)

    Centers for Disease Control (CDC) Podcasts

    2010-04-13

    A message in Spanish from actor Jimmy Smits about the importance of screening for colorectal cancer.  Created: 4/13/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/13/2010.

  7. Message from Jimmy Smits: La Vida Real PSA (:30)

    Centers for Disease Control (CDC) Podcasts

    2010-04-13

    A message in Spanish from actor Jimmy Smits about the importance of screening for colorectal cancer.  Created: 4/13/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/13/2010.

  8. Johnson Mendonca

    Indian Academy of Sciences (India)

    Johnson Mendonca. Articles written in Bulletin of Materials Science. Volume 26 Issue 3 April 2003 pp 355-364 Modeling Studies. Modeling of droplet dynamic and thermal behaviour during spray deposition · N S Mahesh Johnson Mendonca M K Muralidhara B K Muralidhara C Ramachandra · More Details Abstract Fulltext ...

  9. Carl Hirschie Johnson

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Carl Hirschie Johnson. Articles written in Resonance – Journal of Science Education. Volume 11 Issue 5 May 2006 pp 22-31 General Article. Reminiscences from Pittendrigh's Last PhD Student · Carl Hirschie Johnson · More Details Fulltext PDF ...

  10. Johnson, Faith oral history interview

    OpenAIRE

    Interviewee: Johnson, Faith; Interviewer: La, Michelle; Principal Investigator: Hall, Peter V

    2014-01-01

    Faith Johnson is a longshoreman and the daughter-in-law of Dean Johnson (who also worked as a longshoreman in New Westminster and eventually at Westshore before he retired) and wife of Shane Johnson, also a longshoreman.

  11. Terpsichore in Jimmy Choo : a visual reading of relationships between dance and high fashion economies.

    OpenAIRE

    Wongkaew, Manrutt

    2016-01-01

    Terpsichore in Jimmy Choo sets up a relationship between high fashion bodies, material/fabric and theatre dance choreographies. It argues that these relationships have been crucial in twentieth and twenty-first century art dance and fashion practices. It examines the complex web of consumption, negotiation and re-appropriation between dance and fashion. It investigates the relationship between performance, shape, form, fabric, haute couture, modern dance and the bodies that set all of these i...

  12. Johnsons Seagrass Critical Habitat

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent the critical habitat for Johnson's Seagrass as designated by Federal Register Vol. 65, No. 66, Wednesday, April 5, 2000, Rules and Regulations.

  13. Johnson Space Center Overview

    Science.gov (United States)

    Gafka, Tammy; Terrier, Doug; Smith, James

    2011-01-01

    This slide presentation is a review of the work of Johnson Space Center. It includes a section on technology development areas, (i.e., composite structures, non-destructive evaluation, applied nanotechnology, additive manufacturing, and fracture and fatigue analytical methods), a section on structural analysis capabilities within NASA/JSC and a section on Friction stir welding and laser peening.

  14. Mendie, Patrick Johnson

    African Journals Online (AJOL)

    Mendie, Patrick Johnson. Vol 15, No 2 (2015) - Articles An examination of the nexus between Thomas Hobbes‟ concept of human nature and theory of the state. Abstract. ISSN: 1119-443X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  15. Optical Johnson noise thermometry

    Science.gov (United States)

    Shepard, R. L.; Blalock, T. V.; Maxey, L. C.; Roberts, M. J.; Simpson, M. L.

    1989-01-01

    A concept is being explored that an optical analog of the electrical Johnson noise may be used to measure temperature independently of emissivity. The concept is that a laser beam may be modulated on reflection from a hot surface by interaction of the laser photons with the thermally agitated conduction electrons or the lattice phonons, thereby adding noise to the reflected laser beam. If the reflectance noise can be detected and quantified in a background of other noise in the optical and signal processing systems, the reflectance noise may provide a noncontact measurement of the absolute surface temperature and may be independent of the surface's emissivity.

  16. Lyndon B. Johnson on Education.

    Science.gov (United States)

    Morrow, Rosemary

    1981-01-01

    Presents an activity for high school government or U.S. history classes on President Johnson's attitudes toward education. Students analyze and discuss four primary source documents--a speech, memos, presidential remarks on the signing of education amendments, and a political cartoon. They write a paragraph on Johnson's role in education. (AM)

  17. Not radical enough: why Jimmy Carter failed to change American foreign policy

    Directory of Open Access Journals (Sweden)

    Itai Nartzizenfield Sneh

    2009-03-01

    Full Text Available El Presidente Jimmy Carter no consiguió traducir sus palabras e ideales referentes a derechos humanos a hechos y prácticas en la política exterior de E.E.U.U. Carter, ya en el primer período de su administración en 1976-77, tenía una perspectiva demasiado conservadora y tradicional con respecto a las relaciones internacionales. Sus ideas eran correctas, sin embargo seguió enfocando su política en la guerra fría más que en una puesta en práctica constante de un nuevo paradigma para los derechos humanos, especialmente con respecto a los aliados americanos en los territorios subdesarrollados. Carter no reformó suficientemente la práctica de la política exterior de los E.E.U.U. Él no creyó bastantes en la lucha por los derechos humanos así que fue imposible una modifica significativa de las prioridades tradicionales. Carter confió en las políticas, las conductas, las personalidades y estructuras administrativas vigentes. La intención de Carter de cambiar la política americana así como los principios y la comisión, fue minada seriamente por el Consejo de Seguridad Nacional (especialmente Zbigniew Brzezinksi mucho antes de los bien conocidos cambios de SALT II, de los tratados del Canal de Panamá, y del Oriente Medio.__________ABSTRACT:President Jimmy Carter failed to translate his words and ideals concerning human rights into deeds and practices in US foreign policy. Carter, already in the formative period of his administration in 1976-7, was too conservative and traditional in his outlook on international relations. While his heart was at the right place, the Cold War was still his focus rather than a consistent implementation of a new human rights paradigm, especially with respect to American allies in the Developing World. Carter did not sufficiently reform the practice of US foreign policy. He did not believe enough in advocating human rights so a meaningful recast of traditional priorities was difficult. Carter relied on

  18. ACYCLOVIR INDUCED STEVEN JOHNSON SYNDROME

    Directory of Open Access Journals (Sweden)

    Praveena

    2015-04-01

    Full Text Available Acyclovir, anti - viral drug rarely causes Stevens - Johnson syndrome (SJS. Steven Johnson syndrome is a rare, life threatening disorder characterized by skin condition with bullous formation, ocular lesions, genital and anal lesions/ulcers. It’s usually a reaction to a medication or an infection. Often Steven Johnson syndrome begins with flu - like symptoms followed by a painful red or purplish rash that spreads and blisters. Then the top layer of the affected skin dies and sheds. This case report is about a 40 year old male patient who came to the medicine out p atient department with blisters on palms and soles and characteristic hemorrhagic crusting of mouth and lips. Initial diagnosis of Steven Johnson Syndrome was made and treated with steroids. Eruption usually healed without sequelae

  19. Steven-Johnson Syndrome

    Directory of Open Access Journals (Sweden)

    Pauline Joy F. Santos

    2017-07-01

    Full Text Available History of present illness: 72-year-old female with a history of hypertension and rheumatoid arthritis who presented to the emergency department (ED with a chief complaint of rash for the past ten days. Her primary care provider prescribed azithromycin two weeks prior to her arrival in the ED for a sore throat. The rash started on her bilateral lower extremities and spread cephalad. She also noted a prodrome of subjective fevers and malaise. Significant findings: At presentation to the ED, a macular rash was notable on all four extremities, trunk and face, and involved mucous membranes of the oropharynx and vaginal introitus. The rash was painful, erythematous and purpuric with targetoid lesions. There were also multiple areas of sloughing and desquamation with a positive Nikolsky sign. Denudement totaled approximately 2% of total body surface area. Discussion: Stevens-Johnson syndrome (SJS is a dermatolobullous disease on a spectrum of disease that includes toxic epidermal necrolysis (TEN. The distinguishing characteristic is percentage of body surface area (BSA involvement, with SJS involving less than 10% of BSA while TEN involves greater than 30% of BSA.1 Medications are the most common cause of SJS with sulfonamides and penicillin being the most likely culprits (26%. Other medications include acetaminophen, carbamazepine, non-steroidal anti-inflammatory drugs (NSAIDs, phenytoin, and corticosteroids. Malignancy and immunosuppression are both risk factors for SJS.2 Onset of symptoms typically occurs four to twenty-eight days after starting a new medication, and typically presents with a prodrome that may include fever, upper respiratory infection symptoms, headache, and malaise.2 The rash is usually an atypical target lesion that first appears centrally.3 The rash may be painful and almost always has mucous membrane involvement. A positive Nikolsky sign is also seen, which is the sloughing off of epidermis when a shearing force is applied.1

  20. Co-brand strategy of evaluation of visual images in furniture design: Jimmy S.P.A. and STRAUSS as examples

    Science.gov (United States)

    Chen, Tien-Li; Pan, Fang-Ming; Tsai, Jen-Hui

    2013-03-01

    This study aimed to investigate the correlation of the image associated by the design Co-Brand (Jimmy S.P.A. and STRAUSS) and the impression perceived by subject of viewers. Visual images were used to examine the merit of the evaluation. The best result is provided using an object as an appropriate evaluation method. There are a lot of factors which influence to evaluation of a design. This study is limited to distinguish the appearance from Jimmy's picture books transform furniture and so on. Co-Brand of Jimmy S.P.A. and STRAUSS is not easy because there are not from the same cultural, and industry background and applying different marketing strategy, it is a way to combine the two brands by designing, used questionnaire of SD (Semantic differential evaluation) evaluation method to test out the perception of viewers, the objective of this study is to investigate and appraised the Co-Brands use by of the image in furniture from patrons. SD evaluation result showed, if design cannot understand the perception image of Jimmy S.P.A and STRAUSS with viewers mind, furniture design also can't transmit feeling with design.

  1. Ground water in Fountain and Jimmy Camp Valleys, El Paso County, Colorado with a section on Computations of drawdowns caused by the pumping of wells in Fountain Valley

    Science.gov (United States)

    Jenkins, Edward D.; Glover, Robert E.

    1964-01-01

    The part of Fountain Valley considered in this report extends from Colorado Springs to the Pueblo County line. It is 23 miles long and has an area of 26 square miles. The part of Jimmy Camp Valley discussed is 11 miles long and has an area of 9 square miles. The topography is characterized by level flood plains and alluvial terraces that parallel the valley and by rather steep hills along the valley sides. The climate is semiarid, average annual precipitation being about 13 inches. Farming and stock raising are the principal occupations in the valleys; however, some of the agricultural land near Colorado Springs is being used for housing developments. The Pierre Shale and alluvium underlie most of the area, and mesa gravel caps the shale hills adjacent to Fountain Valley. The alluvium yields water to domestic, stock, irrigation, and public-supply wells and is capable of yielding large quantities of water for intermittent periods. Several springs issue along the sides of the valley at the contact of the mesa gravel and the underlying Pierre Shale. The water table ranges in depth from less than 10 feet along the bottom lands to about 80 feet along the sides of the valleys; the saturated thickness ranges from less than a foot to about 50 feet. The ground-water reservoir in Fountain Valley is recharged by precipitation that falls within the area, by percolation from Fountain Creek, which originates in the Pikes Peak, Monument Valley, and Rampart Range areas, and by seepage from irrigation water. This reservoir contains about 70,000 acre-feet of ground water in storage. The ground-water reservoir in Jimmy Camp Valley is recharged from precipitation that falls within the area, by percolation from Jimmy Camp Creek during periods of streamflow, and by seepage from irrigation water. The Jimmy Camp ground-water reservoir contains about 25,000 acre-feet of water in storage. Ground water is discharged from the area by movement to the south, by evaporation and transpiration in

  2. 76 FR 16447 - ETHICON, a Subsidiary of Johnson & Johnson Including On-Site Leased Workers From Kelly Temporary...

    Science.gov (United States)

    2011-03-23

    ... workers of ETHICON, A Johnson and Johnson Company, San Angelo, Texas, separated from employment on or... Johnson & Johnson Including On-Site Leased Workers From Kelly Temporary Services, San Angelo, TX; Amended... of ETHICON, a subsidiary of Johnson & Johnson, including on-site leased workers from Kelly Temporary...

  3. Plaadid : Jimmy Sommerville "Manage The Damage". Marc Almond "Open All Night". Mishka "Mishka". Ma$e "Double Up". Erinevad esitajad "On The Floor At The Botique : mixed by Lo Fidelity Allstars" / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    1999-01-01

    Uutest heliplaatidest : Jimmy Sommerville "Manage The Damage". Marc Almond "Open All Night". Mishka "Mishka". Ma$e "Double Up". Erinevad esitajad "On The Floor At The Botique: mixed by Lo Fidelity Allstars"

  4. What can Johnson & Johnson do to remain a giant in the health care industry?

    Science.gov (United States)

    Carter, Tony

    2002-01-01

    As a major Fortune 500 corporation and manufacturer of significant drug products for the pharmaceutical industry, Johnson & Johnson has also had its share of marketing crisis, including the classic case example of The Tylenol Scare in Fall, 1982, so they can appreciate the need for effective marketing performance and customer responsiveness. This article will examine how Johnson & Johnson has adapted to a highly volatile business environment and how they can be benchmarked for highly competitive marketing strategies and practices.

  5. Prompt versus delayed amniotic membrane application in a patient with acute Stevens-Johnson syndrome

    Science.gov (United States)

    Ciralsky, Jessica B; Sippel, Kimberly C

    2013-01-01

    Background Stevens-Johnson syndrome is often associated with blinding ocular surface cicatricial sequelae. Recent reports have described markedly improved clinical outcomes with the application of amniotic membrane to the ocular surface during the acute phase. Here we describe the clinical outcome of a patient with acute Stevens-Johnson syndrome and severe ocular surface involvement in whom the evolving medical condition and family consent resulted in amniotic membrane application to each eye at differing intervals from disease onset. Methods We undertook a retrospective chart review of a woman with Stevens-Johnson syndrome who presented within hours of disease onset. She underwent application of amniotic membrane to the ocular surface of the left eye during the hyperacute phase (Stevens-Johnson syndrome proved superior. Application of amniotic membrane as soon as possible after disease onset, preferably in the hyperacute phase, appears to result in a significantly better clinical outcome than application later in the disease course. PMID:23754867

  6. History and Evolution of the Johnson Criteria.

    Energy Technology Data Exchange (ETDEWEB)

    Sjaardema, Tracy A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Smith, Collin S. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Birch, Gabriel Carisle [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-07-01

    The Johnson Criteria metric calculates probability of detection of an object imaged by an optical system, and was created in 1958 by John Johnson. As understanding of target detection has improved, detection models have evolved to better model additional factors such as weather, scene content, and object placement. The initial Johnson Criteria, while sufficient for technology and understanding at the time, does not accurately reflect current research into target acquisition and technology. Even though current research shows a dependence on human factors, there appears to be a lack of testing and modeling of human variability.

  7. Caracterización de la neoplasia intraepitelial cervical en mujeres atendidas en el policlínico Jimmy Hirzel

    Directory of Open Access Journals (Sweden)

    Luisa Margarita Sánchez Alarcón

    2015-06-01

    Full Text Available Fundamento: el cáncer de cuello uterino es, después del cáncer de mama, el que más frecuentemente afecta a la mujer. La detección y tratamiento temprano de las neoplasias intraepiteliales cervicales garantizan la calidad de vida ante esta afección. Objetivos: caracterizar a las pacientes con neoplasias intraepiteliales cervicales que son atendidas en el policlínico “Jimmy Hirzel” en el municipio Bayamo, provincia Granma, en el período comprendido entre enero y diciembre de 2013. Métodos: se realizó un estudio descriptivo, retrospectivo, en un universo de 3450 pacientes a las que se realizó citología vaginal en el período de referencia; la muestra fueron las 55 mujeres cuyos exámenes resultaron positivos. Se midieron variables como tipo de neoplasia, edad, inicio de las relaciones sexuales, presencia de cervicitis, sepsis vaginal y hábitos de fumar. Los datos se procesaron por conteo simple, se tabularon utilizando valores absolutos y porcentajes. Resultados: la presencia de la neoplasia intraepitelial cervical fue de un 1,6 %, predominando las de bajo grado (NIC I. El grupo de edad más afectado fue el de 36 a 45 años. Otros factores asociados encontrados con relativa frecuencia, en orden decreciente, fueron: sepsis vaginal, inicio de las relaciones sexuales entre 15-20 años, cervicitis y el hábito de fumar. Conclusiones: existe poca incidencia de las neoplasias intraepiteliales en el área de salud y período estudiados.

  8. Genetics Home Reference: Dubin-Johnson syndrome

    Science.gov (United States)

    ... Jews in Israel. Additionally, several people in the Japanese population have been diagnosed with Dubin-Johnson syndrome . ... of Medicine Lister Hill National Center for Biomedical Communications 8600 Rockville Pike, Bethesda, MD 20894, USA HONCode ...

  9. Hydrology of the Johnson Creek Basin, Oregon

    Science.gov (United States)

    Lee, Karl K.; Snyder, Daniel T.

    2009-01-01

    The Johnson Creek basin is an important resource in the Portland, Oregon, metropolitan area. Johnson Creek forms a wildlife and recreational corridor through densely populated areas of the cities of Milwaukie, Portland, and Gresham, and rural and agricultural areas of Multnomah and Clackamas Counties. The basin has changed as a result of agricultural and urban development, stream channelization, and construction of roads, drains, and other features characteristic of human occupation. Flooding of Johnson Creek is a concern for the public and for water management officials. The interaction of the groundwater and surface-water systems in the Johnson Creek basin also is important. The occurrence of flooding from high groundwater discharge and from a rising water table prompted this study. As the Portland metropolitan area continues to grow, human-induced effects on streams in the Johnson Creek basin will continue. This report provides information on the groundwater and surface-water systems over a range of hydrologic conditions, as well as the interaction these of systems, and will aid in management of water resources in the area. High and low flows of Crystal Springs Creek, a tributary to Johnson Creek, were explained by streamflow and groundwater levels collected for this study, and results from previous studies. High flows of Crystal Springs Creek began in summer 1996, and did not diminish until 2000. Low streamflow of Crystal Springs Creek occurred in 2005. Flow of Crystal Springs Creek related to water-level fluctuations in a nearby well, enabling prediction of streamflow based on groundwater level. Holgate Lake is an ephemeral lake in Southeast Portland that has inundated residential areas several times since the 1940s. The water-surface elevation of the lake closely tracked the elevation of the water table in a nearby well, indicating that the occurrence of the lake is an expression of the water table. Antecedent conditions of the groundwater level and autumn

  10. Reporting společnosti Johnson and Johnson, s. r. o.

    OpenAIRE

    Hejnyš, Jaroslav

    2008-01-01

    The thesis describes the financial background that prevails in the company Johnson & Johnson. It contains the most essential processes which are applied in the financial department. Each event is specified in theoretical way and also described in practical examples. Special attention is given to pricing policy, accountancy system and periodic financial closing.

  11. Stevens-Johnson syndrome after radiotherapy

    International Nuclear Information System (INIS)

    Howell, W.R.; Knight, A.L.; Scruggs, H.J.

    1990-01-01

    We have reported a case of classic Stevens-Johnson syndrome in association with treatment using a cobalt radiation therapy unit. Previous reports of such an association have been extremely rare. At the time of the reaction, the patient's only medications were methyldopa and trichlormethiazide. Other drugs in the thiazide class have been associated with such a reaction. We feel this is an unlikely association in our patient, however, because she had been on trichlormethiazide for a number of years. This report suggests the role of radiotherapy as a rare cause of Stevens-Johnson syndrome. 14 references

  12. Stevens-Johnson syndrome after radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Howell, W.R.; Knight, A.L.; Scruggs, H.J. (Roanoke Memorial Hospitals, VA (USA))

    1990-06-01

    We have reported a case of classic Stevens-Johnson syndrome in association with treatment using a cobalt radiation therapy unit. Previous reports of such an association have been extremely rare. At the time of the reaction, the patient's only medications were methyldopa and trichlormethiazide. Other drugs in the thiazide class have been associated with such a reaction. We feel this is an unlikely association in our patient, however, because she had been on trichlormethiazide for a number of years. This report suggests the role of radiotherapy as a rare cause of Stevens-Johnson syndrome. 14 references.

  13. Networking at NASA. Johnson Space Center

    Science.gov (United States)

    Garman, John R.

    1991-01-01

    A series of viewgraphs on computer networks at the Johnson Space Center (JSC) are given. Topics covered include information resource management (IRM) at JSC, the IRM budget by NASA center, networks evolution, networking as a strategic tool, the Information Services Directorate charter, and SSC network requirements, challenges, and status.

  14. Stevens Johnsons syndrom og toksisk epidermal nekrolyse

    DEFF Research Database (Denmark)

    Kaur-Knudsen, Diljit; Zachariae, Claus; Thomsen, Simon Francis

    2013-01-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most...

  15. Johnson screen for cooling water intakes

    International Nuclear Information System (INIS)

    Cook, L.E.

    1978-01-01

    Johnson surface-water screens provide an alternative to vertical traveling screens for power plant cooling water intakes. In this paper, flow field modeling is discussed, and a series of case studies is presented. The hydraulic information obtained is discussed as it applies to the exclusion of biota and debris from cooling water intake systems

  16. JOHNSON-MATTHEY DIFFUSER CHARACTERIZATION TESTING

    International Nuclear Information System (INIS)

    Foster, P; James Klein, J; Henry Sessions, H; Gregg Morgan, G

    2007-01-01

    A diffuser/permeator commercially fabricated by Johnson-Matthey was purchased for characterization testing at the Savannah River National Laboratory (SRNL). A test system was fabricated to not only feed and bleed flows and pressures, but also permeate pressure for flows up to 20 SLPM

  17. Recent experience in health promotion at Johnson & Johnson: lower health spending, strong return on investment.

    Science.gov (United States)

    Henke, Rachel M; Goetzel, Ron Z; McHugh, Janice; Isaac, Fik

    2011-03-01

    Johnson & Johnson Family of Companies introduced its worksite health promotion program in 1979. The program evolved and is still in place after more than thirty years. We evaluated the program's effect on employees' health risks and health care costs for the period 2002-08. Measured against similar large companies, Johnson & Johnson experienced average annual growth in total medical spending that was 3.7 percentage points lower. Company employees benefited from meaningful reductions in rates of obesity, high blood pressure, high cholesterol, tobacco use, physical inactivity, and poor nutrition. Average annual per employee savings were $565 in 2009 dollars, producing a return on investment equal to a range of $1.88-$3.92 saved for every dollar spent on the program. Because the vast majority of US adults participate in the workforce, positive effects from similar programs could lead to better health and to savings for the nation as a whole.

  18. Johnson & Johnson Asia Pacific Supply Chain: A Value(less) Chain?

    OpenAIRE

    Wong, Wennie

    2008-01-01

    An increasing number of companies claim to pursue International supply chain management (ISCM), but the empirical evidence of successful implementation programs is still scarce. This project aims to contribute in this area by presenting an review of goals, barriers, and enablers on the road towards effective ISCM by Johnson and Johnson Asia Pacific. In today's highly competitive globalized environment, organizations must seek to develop collaborative partnerships and more effective informatio...

  19. Johnson and Johnson strives to implement best practices by year 2000

    International Nuclear Information System (INIS)

    Kauffman, H.A.

    1999-01-01

    Johnson and Johnson is the world's most comprehensive broadly-based manufacturer of health care products. Utilizing a decentralized management philosophy, the 188 operating companies around the world operate independently. Although Johnson and Johnson is not an energy intensive company, it has had a coordinated energy program since 1972. In the 1990s, however, a renewed focus, prompted by the link between energy usage and pollution, led to some very aggressive energy reduction goals to be completed by the end of the year 2000. To assist the operating companies in meeting these goals. a comprehensive set of Best Practices was developed. They cover all facility energy-using equipment and maintenance practices. Inputs included projects completed at Johnson and Johnson facilities worldwide, best practices from several US government voluntary programs, and recommendations from consultants and engineering firms. The end product is now being used worldwide to benchmark the progress. To ensure that these Best Practices are incorporated into new construction as well as the existing facilities, the authors developed their New Facility Design Criteria which is in the format that architectural/engineering firms can easily utilize. They originally validated the Best Practices in two retrofit pilots and two new buildings. They all achieved significant energy savings. As of April 1999, they have completed 62% of the Best Practices at the 96 facilities in the US and Puerto Rico. Twenty-four of these facilities had achieved an 80% completion level in 1998 and were recognized with the internal recognition plaque. Through full implementation of these Best Practices, Johnson and Johnson feel confident that they will be able to meet the Year 2000 energy reduction goals

  20. Signal processing method for Johnson noise thermometry

    International Nuclear Information System (INIS)

    Hwang, I. G.; Moon, B. S.; Kinser, Rpger

    2003-01-01

    The development of Johnson Noise Thermometry requires a high sensitive preamplifier circuit to pick up the temperature-related noise on the sensing element. However, the random noise generated in this amplification circuit causes a significant erroneous influence to the measurement. This paper describes signal processing mechanism of the Johnson Noise Thermometry system which is underway of development in collaboration between KAERI and ORNL. It adopts two identical amplifier channels and utilizes a digital signal processing technique to remove the independent noise of each channel. The CPSD(Cross Power Spectral Density) function is used to cancel the independent noise and the differentiation of narrow or single frequency peak from the CPSD data separates the common mode electromagnetic interference noise

  1. Johnson noise and the thermal Casimir effect

    International Nuclear Information System (INIS)

    Bimonte, Giuseppe

    2007-01-01

    We study the thermal interaction between two nearby thin metallic wires, at finite temperature. It is shown that the Johnson currents in the wires give rise, via inductive coupling, to a repulsive force between them. This thermal interaction exhibits all the puzzling features found recently in the thermal Casimir effect for lossy metallic plates, suggesting that the physical origin of the difficulties encountered in the Casimir problem resides in the inductive coupling between the Johnson currents inside the plates. We show that in our simple model all puzzles are resolved if account is taken of capacitive effects associated with the end points of the wires. Our findings suggest that capacitive finite-size effects may play an important role in the resolution of the analogous problems met in the thermal Casimir effect

  2. The Steven Johnson syndrome. A case study.

    Science.gov (United States)

    Baby, S; Doris, S

    1999-07-01

    Steven Johnson's Syndrome is a serious systemic disorder in which there are vesicobullous lesions involving the skin and mucous membranes. It can result as an immune response to an antigen or as a drug reaction. Most often it is considered as an allergic reaction. It is a self-limiting condition which responds to immediate management or may result in fluid loss, sepsis and death.

  3. Chronic Conditions: Beckett, Bergson and Samuel Johnson.

    Science.gov (United States)

    Maude, Ulrika

    2016-06-01

    This article analyses the work of the twentieth-century late modernist Samuel Beckett, in light of the turn-of-the-century anti-rationalist Henri Bergson (1859-1941) and the eighteenth-century neoclassicist Samuel Johnson (1709-1784). What unites these three very different thinkers is a concern over habitual, automatic and involuntary behavior, which in all three cases has a distinctly neurological dimension. Beckett's writing explores the Bergsonian notion, informed by medicine and experimental psychology, of the limitations of agency, of "the deep-seated recalcitrance of matter," and of the human as always already inflicted by the mechanical, a fact that is poignantly highlighted by the case of Samuel Johnson. Through his encounter with Johnson, Beckett registers a paradigm shift in the understanding of subjectivity. Whereas Bergson aims, throughout his career, to contest the mechanical, habitual and automatic that threaten to encrust themselves upon the living, in Beckett's often uncannily Johnsonian writing, the habitual and the automatic become progressively more central, until in the late works, habit and mechanical behavior constitute a tenuous, fraught and primitive ontology, the residues of an agential self.

  4. Digital signal processing for the Johnson noise thermometry: a time series analysis of the Johnson noise

    International Nuclear Information System (INIS)

    Moon, Byung Soo; Hwang, In Koo; Chung, Chong Eun; Kwon, Kee Choon; David, E. H.; Kisner, R.A.

    2004-06-01

    In this report, we first proved that a random signal obtained by taking the sum of a set of signal frequency signals generates a continuous Markov process. We used this random signal to simulate the Johnson noise and verified that the Johnson noise thermometry can be used to improve the measurements of the reactor coolant temperature within an accuracy of below 0.14%. Secondly, by using this random signal we determined the optimal sampling rate when the frequency band of the Johnson noise signal is given. Also the results of our examination on how good the linearity of the Johnson noise is and how large the relative error of the temperature could become when the temperature increases are described. Thirdly, the results of our analysis on a set of the Johnson noise signal blocks taken from a simple electric circuit are described. We showed that the properties of the continuous Markov process are satisfied even when some channel noises are present. Finally, we describe the algorithm we devised to handle the problem of the time lag in the long-term average or the moving average in a transient state. The algorithm is based on the Haar wavelet and is to estimate the transient temperature that has much smaller time delay. We have shown that the algorithm can track the transient temperature successfully

  5. Oceanographic Data collected during the Florida Shelf Edge Expedition (FLoSEE) (CIOERT2010) on RV Seward Johnson in the Gulf of Mexico and North Atlantic Ocean between July 9, 2010 - August 9, 2010 (NODC Accession 0074541)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A science team on the research vessel Seward Johnson left from Fort Pierce, Fla. in early July to go to the eastern Gulf of Mexico. The researchers used a...

  6. Johnson-Matthey diffuser characterization testing

    International Nuclear Information System (INIS)

    Foster, P. J.; Klein, J. E.; Sessions, H. T.; Morgan, G. A.

    2008-01-01

    A diffuser/permeator commercially fabricated by Johnson-Matthey was purchased for characterization testing at the Savannah River National Laboratory (SRNL). A test system was fabricated to test not only feed and bleed flows and pressures, but also permeate pressure for flows up to 20 sLPM. The tests described in this paper consider the effect of various inert gas types, feed gas compositions, methods for temperature control, and varying tube pressure on permeation of H 2 through the Pd/Ag tubes. (authors)

  7. Imatinib-induced Stevens-Johnsons syndrome.

    Science.gov (United States)

    Jha, Praveen; Himanshu, D; Jain, Nirdesh; Singh, Ajay Kumar

    2013-01-23

    Imatinib mesylate is a tyrosine kinase inhibitor used widely as the first-line treatment for chronic myeloid leukaemia (CML). The side-effect profile of this drug includes fluid retention, muscle cramps, diarrhoea, myelosuppression and skin rashes. Of these, rashes of the type maculo-papular eruptions and oedema developed most commonly. The cutaneous adverse reactions other than maculo-papular eruptions are rare with imatinib. Severe and life-threatening cutaneous reactions can occur in 5% cases. Here, the author reports a case of newly diagnosed CML that developed Steven-Johnsons syndrome due to imatinib therapy. Patient responded and discharged successfully on withdrawal of the culminating drug.

  8. Drugs Induced Stevens-Johnson Syndrome

    Directory of Open Access Journals (Sweden)

    Elif ÖNDER

    2010-05-01

    Full Text Available Stevens Johnson Syndrome (SJS is a life threatening mucocutaneous skin disease that mostlydeveloped after using some drug. SJS mostly appear between 2-4th decades. Mucocutaneouslesions were seen between 1-14 days of drug intake. And these lesions spread diffusely all aroundthe body. First treatment choice is the stopping of drug that cause SJS and giving supportingtreatment. After understanding of underlying cytotoxic and immunological mechanism of SJS,new treatment approaches were developed and mortality of disease was reduced. We hereinreport a short review of drug induced SJS and its treatment.

  9. Stevens-Johnson Syndrome: a Case Report

    Science.gov (United States)

    Castana, O.; Rempelos, G.; Anagiotos, G.; Apostolopoulou, C.; Dimitrouli, A.; Alexakis, D.

    2009-01-01

    Summary The Stevens-Johnson syndrome has the appearance of a partial-thickness burn that may lead to a 100% loss of epidermis, requiring the same resuscitation as a severe burn. A 38-yr-old male patient was admitted to the neurosurgery department of the Evangelismos General Hospital in Athens, where immediately after administration of an antiepileptic drug he developed sloughing of total epidermis, high fever, and the clinical picture of a severe burn patient. He was treated as a burn patient with massive cutaneous injuries and the concomitant systemic effects. Fluid resuscitation was important and the Parkland formula was used, as in a burn patient. Steroid medications were initially administered. Systemic antibiotics were discontinued after signs of sepsis and documented infection had been overcome. Improved treatment techniques and critical burn care have decreased mortality and morbidity in cases of the Stevens-Johnson syndrome. Prompt recognition of the disease and cure of the patient by the appropriate staff of the burns centre contribute to the successful treatment of such patients. PMID:21991171

  10. Stevens-Johnson syndrome in childhood.

    Science.gov (United States)

    Blanco, N; Gutiérrez, B; Valls, I; Puertas, D; Martín, C; Rivera, M; Hernández, Á; Torrelo, A

    2017-05-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are two serious immune diseases within the context of bullous mucocutaneous syndrome. These have varying degrees of involvement of the skin and usually at least two mucous membranes. Three clinical cases are presented, two of them with significant ophthalmological sequelae, who had received drug treatment as a possible trigger, and another milder clinical case caused by Mycoplasma pneumoniae. The ophthalmologist plays a crucial role in the outcome and eye care of the patient in order to try to avoid the appearance of sequelae and subsequent loss of vision. Copyright © 2016 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Napoleon Johnson: From NASA to TV to Community College Teaching.

    Science.gov (United States)

    Neal, John

    1994-01-01

    Describes the life and career of Napoleon Johnson, who currently teaches journalism at Houston Community College's Central Campus. Describes Johnson's experiences as a technical writer for NASA and as a television news correspondent, highlighting the positive effects of these experiences on his career as a college instructor. (MAB)

  12. Steven-Johnson syndrome due to unknown drugs [corrected].

    Science.gov (United States)

    Shivamurthy, Raghu Prasada M; Kallappa, Ravindra; Reddy, Shashikala G H; Rangappa, Druva Kumar B

    2012-01-01

    Steven-Johnson syndrome may be considered as a cytotoxic immune reaction to drugs, infections etc. This is a case report of Steven-Johnson syndrome due to an ayurvedic preparation which was used in the treatment of mental retardation in a young girl.

  13. Steven-Johnson syndrome due to ayurvedic drugs

    OpenAIRE

    Shivamurthy, Raghu Prasada M.; Kallappa, Ravindra; Reddy, Shashikala G. H.; Rangappa, Druva Kumar B.

    2012-01-01

    Steven?Johnson syndrome may be considered as a cytotoxic immune reaction to drugs, infections etc. This is a case report of Steven?Johnson syndrome due to an ayurvedic preparation which was used in the treatment of mental retardation in a young girl.

  14. Survey, applications, and prospects of Johnson noise thermometry

    International Nuclear Information System (INIS)

    Blalock, T.V.; Shepard, R.L.

    1981-01-01

    Significant progress in the field of Johnson noise thermometry has occurred since the 1971 survey of Kamper. This paper will review the foundation work of Johnson noise thermometry, survey the basic methods which do not utilize quantum devices for noise thermometry for industrial temperatures, and present some applications of noise thermometry in temperature scale metrology and process temperature instrumentation. 35 references

  15. Co-amoxiclav-induced Stevens Johnson Syndrome in a child ...

    African Journals Online (AJOL)

    Stevens-Johnson Syndrome is an uncommon life threatening disease generally induced by drugs. Antibiotics, mainly sulphonamides, are the most involved drugs in Stevens-Johnson Syndrome in children. Co-amoxiclav is a well tolerated antibiotic. It has never been reported to cause, lonely this syndrome in children.

  16. Johnson syndrome in a Nigerian woman with chronic lymphocytic ...

    African Journals Online (AJOL)

    Stevens-Johnson syndrome is an adverse muco-cutaneous complication arising from a number of conditions which include the administration of some drugs. A female Nigerian with chronic lymphocytic leukaemia, (Binet stage C) who developed Stevens-Johnson syndrome following commencement of allopurinol is ...

  17. Functional summary statistics for the Johnson-Mehl model

    DEFF Research Database (Denmark)

    Møller, Jesper; Ghorbani, Mohammad

    The Johnson-Mehl germination-growth model is a spatio-temporal point process model which among other things have been used for the description of neurotransmitters datasets. However, for such datasets parametric Johnson-Mehl models fitted by maximum likelihood have yet not been evaluated by means...... of functional summary statistics. This paper therefore invents four functional summary statistics adapted to the Johnson-Mehl model, with two of them based on the second-order properties and the other two on the nuclei-boundary distances for the associated Johnson-Mehl tessellation. The functional summary...... statistics theoretical properties are investigated, non-parametric estimators are suggested, and their usefulness for model checking is examined in a simulation study. The functional summary statistics are also used for checking fitted parametric Johnson-Mehl models for a neurotransmitters dataset....

  18. Labial adhesions caused by Stevens–Johnson syndrome

    Directory of Open Access Journals (Sweden)

    Jung Mi Byun

    2015-12-01

    Full Text Available Vulvovaginal sequelae in Stevens–Johnson syndrome have been widely described in published literature, however, there is no consensus regarding effective preventive treatments. Labial minora synechiae as sequelae of Stevens–Johnson syndrome are rare, but can reduce patients' quality of life as a result of dysuria, urinary tract infection, and sexual dysfunction. Occasionally, sequelae can induce adenosis, and subsequently result in malignancy. Therefore, biopsy of the affected tissue in Stevens–Johnson syndrome patients with genital involvement should be considered after the acute phase has been resolved. Here, we report Stevens–Johnson syndrome with labial involvement in a 24-year-old woman who was treated with labial adhesiolysis. We recommend genital examination for all women with Stevens–Johnson syndrome to diagnose genital disease and avoid urinary tract infections and other sexual complications.

  19. Johnson Space Center Research and Technology Report

    Science.gov (United States)

    Pido, Kelle; Davis, Henry L. (Technical Monitor)

    1999-01-01

    As the principle center for NASA's Human Exploration and Development of Space (HEDS) Enterprise, the Johnson Space Center (JSC) leads NASA's development of human spacecraft, human support systems, and human spacecraft operations. To implement this mission, JSC has focused on developing the infrastructure and partnerships that enable the technology development for future NASA programs. In our efforts to develop key technologies, we have found that collaborative relationships with private industry and academia strengthen our capabilities, infuse innovative ideas, and provide alternative applications for our development projects. The American public has entrusted NASA with the responsibility for space--technology development, and JSC is committed to the transfer of the technologies that we develop to the private sector for further development and application. It is our belief that commercialization of NASA technologies benefits both American industry and NASA through technology innovation and continued partnering. To this end, we present the 1998-1999 JSC Research and Technology Report. As your guide to the current JSC technologies, this report showcases the projects in work at JSC that may be of interest to U.S. industry, academia, and other government agencies (federal, state, and local). For each project, potential alternative uses and commercial applications are described.

  20. [Systemic lupus erythematosus presenting as Stevens-Johnson syndrome].

    Science.gov (United States)

    Bellakhal, S; Ben Kaab, B; Teyeb, Z; Souissi, A; Derbel, F; Douggui, M-H

    2015-09-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatological conditions. Their most common cause is medication. However, in a small proportion of patients these dermatological conditions could be the first presentation of systemic lupus erythematosus. We now describe a 34-year-old patient who presented with manifestations of Stevens-Johnson as a first feature of systemic lupus erythematosus. Systemic lupus erythematosus reveled by Stevens-Johnson syndrome has been infrequently reviewed in the previous literature. This diagnosis should be considered when cutaneous adverse drug reactions occur without clear drug causality. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  1. Russian Keratoprosthesis in Stevens-Johnson Syndrome.

    Science.gov (United States)

    Ma, Xiao; Xiang, Ran; Meng, Xiaoli; Qin, Limin; Wu, Ying; Tain, Lei; Jiang, Yanming; Huang, Yifei; Wang, Liqing

    2017-03-01

    To evaluate the efficacy and safety of Moscow Eye Microsurgery Complex in Russia (MICOF) keratoprosthesis (KPro) implantation in patients with Stevens-Johnson syndrome (SJS). This was a retrospective case series. Fourteen eyes of 13 patients with SJS underwent KPro implantation at the Chinese People's Liberation Army General Hospital between April 1, 2000, and December 24, 2014. The visual outcome, KPro retention rate, and incidence of postoperative complications and their management were recorded and investigated. The mean age and follow-up duration were 61.5 ± 17.3 years (range: 27-87 yrs) and 62 ± 39.1 months (range: 13-144 mo). Thirteen eyes (92.9%) achieved a best-corrected visual acuity of 20/200 or better, and 8 eyes (57.1%) achieved a best-corrected visual acuity of 20/40 or better after surgery. However, 71.4% (10/14) experienced visual decline because of different postoperative complications. Common complications included corneal melting, glaucoma, vitritis, superficial tissue overgrowth, and retroprosthetic membrane, and the incidence of these complications was 71.4%, 28.6%, 35.7%, 14.3%, and 28.6%, respectively. After repair and autoauricular cartilage reinforcement, all cases had stable anatomical retention at the last visit. The MICOF KPro improved vision of patients with SJS, but lifelong surveillance is necessitated because of a high rate of postoperative complications. Corneal melting was the main reason for KPro failure. Infectious endophthalmitis and glaucoma were the main risk factors for visual loss.

  2. Renewable Energy at NASA's Johnson Space Center

    Science.gov (United States)

    McDowall, Lindsay

    2014-01-01

    NASA's Johnson Space Center has implemented a great number of renewable energy systems. Renewable energy systems are necessary to research and implement if we humans are expected to continue to grow and thrive on this planet. These systems generate energy using renewable sources - water, wind, sun - things that we will not run out of. Johnson Space Center is helping to pave the way by installing and studying various renewable energy systems. The objective of this report will be to examine the completed renewable energy projects at NASA's Johnson Space Center for a time span of ten years, beginning in 2003 and ending in early 2014. This report will analyze the success of each project based on actual vs. projected savings and actual vs. projected efficiency. Additionally, both positive and negative experiences are documented so that lessons may be learned from past experiences. NASA is incorporating renewable energy wherever it can, including into buildings. According to the 2012 JSC Annual Sustainability Report, there are 321,660 square feet of green building space on JSC's campus. The two projects discussed here are major contributors to that statistic. These buildings were designed to meet various Leadership in Energy and Environmental Design (LEED) Certification criteria. LEED Certified buildings use 30 to 50 percent less energy and water compared to non-LEED buildings. The objectives of this project were to examine data from the renewable energy systems in two of the green buildings onsite - Building 12 and Building 20. In Building 12, data was examined from the solar photovoltaic arrays. In Building 20, data was examined from the solar water heater system. By examining the data from the two buildings, it could be determined if the renewable energy systems are operating efficiently. Objectives In Building 12, the data from the solar photovoltaic arrays shows that the system is continuously collecting energy from the sun, as shown by the graph below. Building 12

  3. Phenytoin induced Stevens-Johnson syndrome exacerbated by cefepime

    OpenAIRE

    Prabhu, Varsha A.; Doddapaneni, Sahiti; Thunga, Girish; Thiyagu, Rajakannan; Prabhu, M. Mukyaprana; Naha, Kushal

    2013-01-01

    Steven Johnson syndrome (SJS) is a rare drug induced mucocutaneous reaction. Here, we present an elaborate report of a 28-year-old female patient who developed Phenytoin induced SJS, which was exacerbated by cefepime.

  4. Phenytoin induced Stevens-Johnson syndrome exacerbated by cefepime.

    Science.gov (United States)

    Prabhu, Varsha A; Doddapaneni, Sahiti; Thunga, Girish; Thiyagu, Rajakannan; Prabhu, M Mukyaprana; Naha, Kushal

    2013-10-01

    Steven Johnson syndrome (SJS) is a rare drug induced mucocutaneous reaction. Here, we present an elaborate report of a 28-year-old female patient who developed Phenytoin induced SJS, which was exacerbated by cefepime.

  5. Lyndon Baines Johnson signs the Wilderness Act into law

    Science.gov (United States)

    Susan A. Fox

    2016-01-01

    President Lyndon Baines Johnson signed the Wilderness Act into law on Sept. 3, 1964. In this photo, LBJ hands the pen he used to Alice Zahniser while naturalist, author, adventurer, and conservationist Mardy Murie (standing behind her) looks on.

  6. Lingual botryomycoma in the aftermath of Stevens-Johnson syndrome

    African Journals Online (AJOL)

    Johnson syndrome with severe mucosal impairment appeared three weeks after taking allopurinol (Zyloric®) for an hyperuricemia associated with arthralgia. She was put under symptomatic treatment after discontinuation of the offending molecule ...

  7. Understanding Presidential Rhetoric: The Vietnam Statements of Lyndon Johnson

    Science.gov (United States)

    Sigelman, Lee; Miller, Lawrence

    1978-01-01

    Focuses on Lyndon Johnson's public statements about Vietnam during the final eighteen months of his presidency in an attempt to gain a perspective on the factors which shape presidential rhetoric. (MH)

  8. XXI sajandi kontuurid / Paul Johnson ; refereerinud Mihkel Mutt

    Index Scriptorium Estoniae

    Johnson, Paul

    1997-01-01

    Washingtonis 14.-16. juunini peetud 'Lääne kirjanduse konverentsil' pidas põhiettekande ameerika ajaloolane ja publitsist Paul Johnson. Refereering tema 'XXI sajandi geopoliitiliste ja kultuuriliste väljavaadete' seisukohtadest

  9. Application of the Johnson criteria to graphene transistors

    International Nuclear Information System (INIS)

    Kelly, M J

    2013-01-01

    For 60 years, the Johnson criteria have guided the development of materials and the materials choices for field-effect and bipolar transistor technology. Intrinsic graphene is a semi-metal, precluding transistor applications, but only under lateral bias is a gap opened and transistor action possible. This first application of the Johnson criteria to biased graphene suggests that this material will struggle to ever achieve competitive commercial applications. (fast track communication)

  10. Norine G. Johnson (1935-2011).

    Science.gov (United States)

    Cantor, Dorothy W; Goodheart, Carol D

    2012-04-01

    On November 19, 2011, Norine G. Johnson, the ninth woman to serve as president of the American Psychological Association (APA), lost a valiant battle with cancer. Norine's curiosity about her grandmother's strength led to much of her later work on the development of strength and resiliency in adolescent girls and in women. She received her doctorate in 1972, with a minor in child development, and she became one of the first to be considered a pediatric psychologist, a newly emerging specialty. Norine became involved in organized psychology as her children got older. When she learned there had not been a woman president of the Massachusetts Psychological Association (MPA) for almost 50 years, she was appalled. An ardent feminist, who had served on MPA's Board of Directors, she could not let the situation remain that way. She ran for president and won, serving from 1981 to 1983, and then mentored many women colleagues into the role. MPA sent her to the Council of the APA as one of their representatives, and she immediately ran for a seat on the Finance Committee, later serving as chair of the committee. During her tenure on the Finance Committee, she helped create financial policy that changed APA from an organization whose assets were threatened and shrinking to a financially solid association. Norine considered Division 35 (Psychology of Women) to be her home in APA, a place filled with warmth, collegiality, and shared values. She and Judith Worell spearheaded the extremely important and successful 1993 National Conference on Education and Training in Feminist Practice. Norine was elected to the APA Board of Directors in 1997, where she served with distinction, continuing to focus on the financial well-being of the Association. Not surprisingly, she went from that role to being elected APA president. Her focus as president was on the changes in the health care delivery system in the United States. She was a staunch champion of the biopsychosocial model of health

  11. ARE LEFT HANDED SURGEONS LEFT OUT?

    OpenAIRE

    SriKamkshi Kothandaraman; Balasubramanian Thiagarajan

    2012-01-01

    Being a left-handed surgeon, more specifically a left-handed ENT surgeon, presents a unique pattern of difficulties.This article is an overview of left-handedness and a personal account of the specific difficulties a left-handed ENT surgeon faces.

  12. Incomplete Stevens-Johnson syndrome secondary to atypical pneumonia.

    Science.gov (United States)

    Ramasamy, Anantharaman; Patel, Chiraush; Conlon, Christopher

    2011-10-04

    Steven-Johnson syndrome is a common condition characterised by erythematous target lesions on the skin and involvement of the oral mucosa, genitals and conjunctivae. It has been documented as one of the extra-pulmonary manifestations of Mycoplasma pneumoniae infection. Recently, there has been several documentation of an incomplete presentation of this syndrome - without the typical rash but with mucosal, conjunctival and genital involvement. Our case illustrates that the incomplete Steven-Johnson syndrome may present with oral mucosal and conjunctival involvement alone without skin or genital involvement. This important clinical diagnosis should not be missed due to its atypical presentation. Treatment of Steven-Johnson syndrome remains supportive along with treating the underlying infection if recognised.

  13. Survey on Johnson noise thermometry for temperature instrumentation

    International Nuclear Information System (INIS)

    Hwang, I. K.; Kim, Y. K.; Kim, J. S.; Moon, B. S.

    2002-01-01

    Johnson Noise Thermometry is an drift-free temperature measurement method which is able to maintain the best accuracy without calibration for a long period. Resistance Temperature Detectors (RTDs) and Thermocouples used widely in power plants have the drift problem which causes a measurement error. Despite the advantage of Johnson Noise thermometry, it has not been used because it is very sensitive to electromagnetic noise and environment. It also requires more complicated signal processing methods. This paper presents the characteristics of Johnson Noise thermometry and various implementation method proposed over the past decades time period. The key factor in development of a noise thermometer is how to extract the tiny noise signal from the sensor and discriminate out the unnecessary noise interference from the environments. The new digital technology of fast signal processing skill will useful to challenge the existing problems fir commercialization of noise thermometry

  14. Cefepime Associated With Phenytoin Induced Stevens-Johnson Syndrome.

    Science.gov (United States)

    Marco-Del Río, José; Domingo-Chiva, Esther; Cuesta-Montero, Pablo; Valladolid-Walsh, Ana; García-Martínez, Eva María

    We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. The next day he developed a "maculous cutaneous eruption in trunk and lower limbs" compatible with a Stevens-Johnson Syndrome. Stevens-Johnson Syndrome is a very severe and potentially fatal multiorganic disease, especially when present in critically ill patients, with a strong drug-related etiology, especially with antiepileptic drugs.

  15. Canonical extensions of the Johnson homomorphisms to the Torelli groupoid

    DEFF Research Database (Denmark)

    Bene, Alex; Kawazumi, Nariya; Penner, Robert

    2009-01-01

    We prove that every trivalent marked bordered fatgraph comes equipped with a canonical generalized Magnus expansion in the sense of Kawazumi. This Magnus expansion is used to give canonical extensions of the higher Johnson homomorphisms τm , for m 1 , to the Torelli groupoid, and we provide...... a recursive combinatorial formula for tensor representatives of these extensions. In particular, we give an explicit 1-cocycle in the dual fatgraph complex which extends τ2 and thus answer affirmatively a question of Morita and Penner. To illustrate our techniques for calculating higher Johnson homomorphisms...

  16. Band gap calculations with Becke-Johnson exchange potential

    International Nuclear Information System (INIS)

    Tran, Fabien; Blaha, Peter; Schwarz, Karlheinz

    2007-01-01

    Recently, a simple analytical form for the exchange potential was proposed by Becke and Johnson. This potential, which depends on the kinetic-energy density, was shown to reproduce very well the shape of the exact exchange potential (obtained with the optimized effective potential method) for atoms. Calculations on solids show that the Becke-Johnson potential leads to a better description of band gaps of semiconductors and insulators with respect to the standard local density and Perdew-Burke-Ernzerhof approximations for the exchange-correlation potential. Comparison is also made with the values obtained with the Engel-Vosko exchange potential which was also developed using the exact exchange potential

  17. Energy Systems Integration Partnerships: NREL + Sandia + Johnson Controls

    Energy Technology Data Exchange (ETDEWEB)

    2017-04-05

    NREL and Sandia National Laboratories partnered with Johnson Controls to deploy the company's BlueStream Hybrid Cooling System at ESIF's high-performance computing data center to reduce water consumption seen in evaporative cooling towers.

  18. Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis ...

    African Journals Online (AJOL)

    implicated drugs are nevirapine and co-trimoxazole.3. SJS and TEN rarely occur without any prior drug use, and in the .... bacterial infection due to low saliva production and ulceration with fibrinous exudative inflammation which .... PH, Bouchard CS, Dart JK, Gai X, Gomes JA. Stevens-Johnson Syndrome/. Toxic Epidermal ...

  19. Steven Johnson syndrome in a patient with Cushing's disease.

    Science.gov (United States)

    Mustafa, N; Periyasamy, P; Kamaruddin, N

    2009-09-01

    Cushing's syndrome is a pathological condition associated with excessive cortisol production, the commonest etiology being Cushing's disease. Corticosteroids in high doses have been used in the management of Steven Johnson Syndrome (SJS) with favourable outcome. We describe a patient with Cushing's disease who developed SJS, one week after taking sperulina a product from sea-weed while waiting for transphenoidal surgery.

  20. Risk of nevirapine-associated Stevens-Johnson syndrome among ...

    African Journals Online (AJOL)

    Background. Stevens-Johnson syndrome (SJS) is an acute life-threatening condition often elicited by drugs. The government's indecisiveness in deciding to stop the use of nevirapine (NVP) in HIV-infected pregnant women owing to the increase of SJS among this population group in South Africa prompted this investigation ...

  1. Lunar Roving Vehicle Testing at the Johnson Space Center

    Science.gov (United States)

    1972-01-01

    This photograph was taken during the testing of the Lunar Roving Vehicle (LRV) at the Johnson Space Center. Developed by the MSFC, the LRV was the lightweight electric car designed to increase the range of mobility and productivity of astronauts on the lunar surface. It was used on the last three Apollo missions; Apollo 15, Apollo 16, and Apollo 17.

  2. Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis ...

    African Journals Online (AJOL)

    Stevens-Johnson syndrome (SJS) is a form of toxic epidermal necrolysis (TEN) a rare but life-threatening hypersensitivity reactions that affect the skin and mucous membranes. The most common triggers are drugs, but they can also be triggered by infections. Granulysin has been recently identified as the major molecule ...

  3. Scott Morgan Johnson Middle School: Personalization Leads to Unlimited Success

    Science.gov (United States)

    Principal Leadership, 2013

    2013-01-01

    The well-known lyrics may be "The Eyes of Texas Are Upon You," but at Scott Morgan Johnson Middle School in McKinney, TX, it's definitely the "eye of the tiger" that sets the bar for Tiger PRIDE (perseverance, respect, integrity, determination, and excellence). This article describes how those ideals have been infused…

  4. Status and Monitoring of Natural and Supplemented Chinook Salmon in Johnson Creek, Idaho, 2006-2007 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Rabe, Craig D.; Nelson, Douglas D. [Nez Perce Tribe

    2008-11-17

    The Nez Perce Tribe Johnson Creek Artificial Propagation Enhancement Project (JCAPE) has conducted juvenile and adult monitoring and evaluation studies for its 10th consecutive year. Completion of adult and juvenile Chinook salmon studies were conducted for the purpose of evaluating a small-scale production initiative designed to increase the survival of a weak but recoverable spawning aggregate of summer Chinook salmon Oncorhynchus tshawytscha. The JCAPE program evaluates the life cycle of natural origin (NOR) and hatchery origin (HOR) supplementation fish to quantify the key performance measures: abundance, survival-productivity, distribution, genetics, life history, habitat, and in-hatchery metrics. Operation of a picket style weir and intensive multiple spawning ground surveys were completed to monitor adult Chinook salmon and a rotary screw trap was used to monitor migrating juvenile Chinook salmon in Johnson Creek. In 2007, spawning ground surveys were conducted on all available spawning habitat in Johnson Creek and one of its tributaries. A total of 63 redds were observed in the index reach and 11 redds for all other reaches for a combined count of 74 redds. Utilization of carcass recovery surveys and adult captures at an adult picket weir yielded a total estimated adult escapement to Johnson Creek of 438 Chinook salmon. Upon deducting fish removed for broodstock (n=52), weir mortality/ known strays (n=12), and prespawning mortality (n=15), an estimated 359 summer Chinook salmon were available to spawn. Estimated total migration of brood year 2005 NOR juvenile Chinook salmon at the rotary screw trap was calculated for three seasons (summer, fall, and spring). The total estimated migration was 34,194 fish; 26,671 of the NOR migrants left in the summer (July 1 to August 31, 2005) as fry/parr, 5,852 left in the fall (September 1 to November 21, 2005) as presmolt, and only 1,671 NOR fish left in the spring (March 1 to June 30, 2006) as smolt. In addition, there

  5. Developing flood-inundation maps for Johnson Creek, Portland, Oregon

    Science.gov (United States)

    Stonewall, Adam J.; Beal, Benjamin A.

    2017-04-14

    Digital flood-inundation maps were created for a 12.9‑mile reach of Johnson Creek by the U.S. Geological Survey (USGS). The flood-inundation maps depict estimates of water depth and areal extent of flooding from the mouth of Johnson Creek to just upstream of Southeast 174th Avenue in Portland, Oregon. Each flood-inundation map is based on a specific water level and associated streamflow at the USGS streamgage, Johnson Creek at Sycamore, Oregon (14211500), which is located near the upstream boundary of the maps. The maps produced by the USGS, and the forecasted flood hydrographs produced by National Weather Service River Forecast Center can be accessed through the USGS Flood Inundation Mapper Web site (http://wimcloud.usgs.gov/apps/FIM/FloodInundationMapper.html).Water-surface elevations were computed for Johnson Creek using a combined one-dimensional and two‑dimensional unsteady hydraulic flow model. The model was calibrated using data collected from the flood of December 2015 (including the calculated streamflows at two USGS streamgages on Johnson Creek) and validated with data from the flood of January 2009. Results were typically within 0.6 foot (ft) of recorded or measured water-surface elevations from the December 2015 flood, and within 0.8 ft from the January 2009 flood. Output from the hydraulic model was used to create eight flood inundation maps ranging in stage from 9 to 16 ft. Boundary condition hydrographs were identical in shape to those from the December 2015 flood event, but were scaled up or down to produce the amount of streamflow corresponding to a specific water-surface elevation at the Sycamore streamgage (14211500). Sensitivity analyses using other hydrograph shapes, and a version of the model in which the peak flow is maintained for an extended period of time, showed minimal variation, except for overbank areas near the Foster Floodplain Natural Area.Simulated water-surface profiles were combined with light detection and ranging (lidar

  6. 77 FR 24988 - Manufacturer of Controlled Substances; Notice of Registration; Johnson Matthey Pharma Services

    Science.gov (United States)

    2012-04-26

    ... time. DEA has investigated Johnson Matthey Pharma Services to ensure that the company's registration is...; Notice of Registration; Johnson Matthey Pharma Services By Notice dated December 5, 2011, and published in the Federal Register on December 12, 2011, 76 FR 77257, Johnson Matthey Pharma Services, 70...

  7. 77 FR 16263 - Manufacturer of Controlled Substances, Notice of Registration; Johnson Matthey Inc.

    Science.gov (United States)

    2012-03-20

    ... the public interest at this time. DEA has investigated Johnson Matthey Inc. to ensure that the company..., Notice of Registration; Johnson Matthey Inc. By Notice dated November 18, 2011, and published in the Federal Register on November 28, 2011, 76 FR 72974, Johnson Matthey Inc., Custom Pharmaceuticals...

  8. 77 FR 16262 - Importer of Controlled Substances, Notice of Registration; Johnson Matthey, Inc., Pharmaceutical...

    Science.gov (United States)

    2012-03-20

    ... has investigated Johnson Matthey, Inc. to ensure that the company's registration is consistent with... Registration; Johnson Matthey, Inc., Pharmaceutical Materials By Notice dated December 2, 2011, and published in the Federal Register on December 12, 2011, 76 FR 77253, Johnson Matthey, Inc., Pharmaceutical...

  9. 78 FR 16298 - Manufacturer of Controlled Substances, Notice of Registration; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-03-14

    ... interest at this time. DEA has investigated Johnson Matthey, Inc., to ensure that the company's..., Notice of Registration; Johnson Matthey, Inc. By Notice dated November 5, 2012, and published in the Federal Register on November 13, 2012, 77 FR 67676, Johnson Matthey, Inc., Custom Pharmaceuticals...

  10. 77 FR 24988 - Manufacturer of Controlled Substances; Notice of Registration; Johnson Matthey Inc.

    Science.gov (United States)

    2012-04-26

    .... DEA has investigated Johnson Matthey Inc. to ensure that the company's registration is consistent with...; Notice of Registration; Johnson Matthey Inc. By Notice dated November 21, 2011, and published in the Federal Register on November 29, 2011, 76 FR 73679, Johnson Matthey Inc., Pharmaceuticals Materials, 900...

  11. Acetaminophen induced Steven Johnson syndrome-toxic epidermal necrolysis overlap.

    Science.gov (United States)

    Khawaja, Ali; Shahab, Ahmed; Hussain, Syed Ather

    2012-05-01

    Steven Johnson Syndrome and Toxic Epidermal Necrolysis are rare but severe form of hypersensitivity inflammatory reactions to multiple offending agents including drugs. Acetaminophen is extensively used due to its analgesic and anti-pyretic properties. It is rendered to be relatively safe, with hepatotoxicity considered to be the major adverse effect. However, very few cases of Steven Johnson Syndrome and Toxic Epidermal Necrolysis have been reported with acetaminophen usage in the past. We present the case of a 40 years old lady who developed an overlap of the two condition after taking several doses of acetaminophen for fever. She presented with widespread maculopapular rash, stinging in the eyes, oral mucosal ulcerations and high grade fever. She was successfully treated with corticosteroid therapy along with the supportive treatment. This case addresses the fact, that severe hypersensitivity reactions can occur with acetaminophen which can be potentially life threatening.

  12. Development of high frequency and wide bandwidth Johnson noise thermometry

    International Nuclear Information System (INIS)

    Crossno, Jesse; Liu, Xiaomeng; Kim, Philip; Ohki, Thomas A.; Fong, Kin Chung

    2015-01-01

    We develop a high frequency, wide bandwidth radiometer operating at room temperature, which augments the traditional technique of Johnson noise thermometry for nanoscale thermal transport studies. Employing low noise amplifiers and an analog multiplier operating at 2 GHz, auto- and cross-correlated Johnson noise measurements are performed in the temperature range of 3 to 300 K, achieving a sensitivity of 5.5 mK (110 ppm) in 1 s of integration time. This setup allows us to measure the thermal conductance of a boron nitride encapsulated monolayer graphene device over a wide temperature range. Our data show a high power law (T ∼ 4) deviation from the Wiedemann-Franz law above T ∼ 100 K

  13. Steven johnsons syndrome and toxic epidermal necrolysis: A review

    OpenAIRE

    Sri ram Anne; Sreya Kosanam; Lakshmi Prasanthi N

    2014-01-01

    Toxic epidermal necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infection...

  14. Johnson-McMillin microtia syndrome: New additional family

    OpenAIRE

    Nagwa Abdel-Meguid; Ola Hosny Gebril; Ehab Ragaa Abdelraouf; Mohammed Akmal Shafie; Mohammed Bahgat

    2014-01-01

    Microtia is a congenital anomaly that is found with different prevalence among various populations. The exact etiology of ear anomalies is still unknown. We describe a new additional family with this rare disorder; Johnson-McMillin syndrome (JMS) where mother, son, and distant grandmother have multiple features of JMS in the form of microtia, facial asymmetry, ear malformation, hearing defect, and hypotrichosis. Variable presentations in this family could be referred to phenotype variation su...

  15. Incomplete Stevens–Johnson syndrome secondary to atypical pneumonia

    OpenAIRE

    Ramasamy, Anantharaman; Patel, Chiraush; Conlon, Christopher

    2011-01-01

    Steven-Johnson syndrome is a common condition characterised by erythematous target lesions on the skin and involvement of the oral mucosa, genitals and conjunctivae. It has been documented as one of the extra-pulmonary manifestations of Mycoplasma pneumoniae infection. Recently, there has been several documentation of an incomplete presentation of this syndrome – without the typical rash but with mucosal, conjunctival and genital involvement. Our case illustrates that the incomplete Steven-Jo...

  16. Ivermectin induced Steven-Johnsons syndrome: case report.

    Science.gov (United States)

    Aroke, Desmond; Tchouakam, Diego Nitcheu; Awungia, Alexis Tazinya; Mapoh, Sylvester Yari; Ngassa, Stewart Ndutard; Kadia, Benjamin Momo

    2017-05-08

    Stevens-Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit. A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign. He had no known chronic illness, no known allergies and was not on any medications prior to the campaign. Physical examination revealed discharging erythematous eyes, crusted and blister-like lesions with cracks on his lips and oral mucosa. His laboratory tests were unremarkable but for a positive Human Immunodeficiency Virus (HIV) test. A diagnosis of Ivermectin induced Stevens-Johnson syndrome in a newly diagnosed HIV patient was made. The patient was managed with supportive therapy and the evolution thereafter was favourable. Stevens-Johnson syndrome is a potential side effect of ivermectin and susceptibility to this adverse effect may be increased in HIV infection.

  17. Severe jaundice due to coexistence of Dubin-Johnson syndrome and hereditary spherocytosis: a case report.

    Science.gov (United States)

    Korkmaz, Uğur; Duman, Ali Erkan; Oğütmen Koç, Deniz; Gürbüz, Yeşim; Dındar, Gökhan; Ensaroğlu, Fatih; Sener, Selçuk Yusuf; Sentürk, Omer; Hülagü, Sadettin

    2011-08-01

    Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia. The level of bilirubin is not expected to be more than 20 mg/dl in this syndrome. In this article, we report a patient who was evaluated for hyperbilirubinemia and liver function test abnormalities and diagnosed with Dubin-Johnson syndrome coexisting with hereditary spherocytosis. We suggest that other diseases should be investigated if patients with Dubin-Johnson syndrome present with severe hyperbilirubinemia. Dubin-Johnson syndrome accompanied by hemolytic diseases might also have high coproporphyrin levels (as in Rotor's syndrome) than expected in pure Dubin-Johnson syndrome.

  18. JOHNSON & KASKA 1965 FOSSIL CORALLINE ALGAE FROM GUATEMALA (REVISION OF THE JESSE HARLAN JOHNSON COLLECTION, PART 4

    Directory of Open Access Journals (Sweden)

    DANIELA BASSO

    2018-01-01

    Full Text Available The original collections of eight species described by Johnson & Kaska (1965 from several Guatemalan localities and ages, have been examined, re-documented and critically revised. The generic placement of Aethesolithon guatemalaensum, Lithothamnium? primitiva, Lithothamnium diagramaticum, Lithothamnium guatemalense, Lithothamnium toltecensum, and Jania occidentalis resulted incorrect under modern taxonomic criteria, and changed accordingly, while a lectotype specimen was selected for Amphiroa guatemalense and Amphiroa kaskaella. We place tentatively L. diagramaticum in the new combination Sporolithon? diagramaticum on the base of the occurrence of secondary pit-connections and vegetative and reproductive anatomy corresponding to some extant species of the genus Sporolithon. L. toltecensum was based on few Miocene sterile thalli occurring with some fertile specimens of the same age - the latter incorrectly identified under the name L. florea brassica (Millet Lemoine - both corresponding to the extant, long-lasting species Lithothamnion crispatum Hauck. The occurrence of large cell fusions and trichocytes, the shape and structure of the uniporate conceptacles and the dimerous construction collectively indicate that Aethesolithon guatemalaensum belongs to the genus Hydrolithon, with the new combination H. guatemalaensum (Johnson & Kaska Basso & Granier. The vegetative anatomy of Jania occidentalis corresponds to that of a co-occurring Corallina, already identified as C. matansa Johnson. Lithothamnium? primitiva is not a coralline alga, since it is conspecific with Marinella lugeoni Pfender. The vegetative features of the sterile “Lithothamnium guatemalense” exclude it from the genus Lithothamnion, but the absence of important diagnostic characters suggests leaving it incertae sedis under the original binomial.

  19. [Stevens-Johnson's syndrome following ingestion of gunpowder].

    Science.gov (United States)

    Kouotou, E-A; Defo, D; Zoung-Kanyi Bissek, A-C; Ndjitoyap Ndam, E-C; Beylot-Barry, M

    2012-10-01

    A cutaneous adverse drug reaction is a skin eruption secondary to the intake of a drug, be it prescribed by a medical practitioner or taken as auto-medication for a given ailment. In this document we present an original case of Stevens-Johnson's syndrome secondary to the ingestion of gunpowder. A 22-year-old female student was hospitalised for diffuse and painful skin eruptions for the previous three days. She had complained six days earlier of an allergic reaction to pineapples, an allergy she had presented for quite a long time. In an attempt to remedy the situation, her mother made her drink a solution made of gunpowder bought at a market mixed with some water. On the third day of this "treatment", the patient noticed eruptions on her skin. These were initially maculopapular, later becoming erosive, and she had a mild fever. Later, a variety of eruptions appeared on the skin, from hyper-pigmented macular papules to blisters and erosive lesions with no Nicolsky sign. These lesions spared the palms of the hands and the soles of the feet. The mucosa of the conjunctivae, nose, buccal cavity, vulva, vagina and anus were severely affected. This clinical presentation was typical of Steven Johnson syndrome. The patient had stopped taking the "treatment" when she noticed the first lesions. On therapy, the outcome was favourable, except for severe complications such as synechiae with diffuse dyschromia. To the best of our knowledge this is the first time gunpowder has been incriminated in Stevens-Johnson's syndrome. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  20. Transnational Impulses as Simulation in Colin Johnson's (Mudrooroo's Fiction.

    Directory of Open Access Journals (Sweden)

    Clare Archer-Lean

    2013-05-01

    Full Text Available Works of Australian Literature have frequently been situated within national literary frameworks. But there is much recent scholarship that contests such ideas and explores transnational engagement in literary production. An author that has been seen as embodying the spectral nature of the Australian literary paradigm is Colin Johnson, pseudonym Mudrooroo. While, the complexities around Mudrooroo's identity as black Australian author are infamous: these biographical complexities are not the focus of this paper. Instead, Mudrooroo's Master of the Ghost Dreaming Series is explored as an evocation of place that encompasses a series of ever widening spheres: the local, the regional, the national, the transnational, the trans-human and the cosmic.

  1. Taxonomy, Ontology and Semantics at Johnson Space Center

    Science.gov (United States)

    Berndt, Sarah Ann

    2011-01-01

    At NASA Johnson Space Center (JSC), the Chief Knowledge Officer has been developing the JSC Taxonomy to capitalize on the accomplishments of yesterday while maintaining the flexibility needed for the evolving information environment of today. A clear vision and scope for the semantic system is integral to its success. The vision for the JSC Taxonomy is to connect information stovepipes to present a unified view for information and knowledge across the Center, across organizations, and across decades. Semantic search at JSC means seemless integration of disparate information sets into a single interface. Ever increasing use, interest, and organizational participation mark successful integration and provide the framework for future application.

  2. A NOVEL TECHNIQUE APPLYING SPECTRAL ESTIMATION TO JOHNSON NOISE THERMOMETRY

    Energy Technology Data Exchange (ETDEWEB)

    Ezell, N Dianne Bull [ORNL; Britton Jr, Charles L [ORNL; Roberts, Michael [ORNL; Holcomb, David Eugene [ORNL; Ericson, Milton Nance [ORNL; Djouadi, Seddik M [ORNL; Wood, Richard Thomas [ORNL

    2017-01-01

    Johnson noise thermometry (JNT) is one of many important measurements used to monitor the safety levels and stability in a nuclear reactor. However, this measurement is very dependent on the electromagnetic environment. Properly removing unwanted electromagnetic interference (EMI) is critical for accurate drift free temperature measurements. The two techniques developed by Oak Ridge National Laboratory (ORNL) to remove transient and periodic EMI are briefly discussed in this document. Spectral estimation is a key component in the signal processing algorithm utilized for EMI removal and temperature calculation. Applying these techniques requires the simple addition of the electronics and signal processing to existing resistive thermometers.

  3. Stevens-Johnson syndrome associated with Malarone antimalarial prophylaxis.

    Science.gov (United States)

    Emberger, Michael; Lechner, Arno Michael; Zelger, Bernhard

    2003-07-01

    To the best of our knowledge, Stevens-Johnson syndrome (SJS) has not been reported previously as an adverse reaction to Malarone, which is a combination of atovaquone and proguanil hydrochloride used for antimalarial prophylaxis and therapy. We describe a 65-year-old patient who had SJS with typical clinical and histopathological findings associated with the use of Malarone prophylaxis for malaria. This report should alert physicians to this severe cutaneous reaction, and Malarone should be added to the list of drugs that can potentially cause SJS.

  4. First case of Stevens-Johnson syndrome after rabies vaccination.

    Science.gov (United States)

    Ma, Li; Du, Xusheng; Dong, Yu; Peng, Lirong; Han, Xiaonian; Lyu, Jianhua; Bai, Hehe

    2018-01-15

    We describe the first case of Stevens-Johnson syndrome (SJS) occurring 8 days after the first dose of a three-dose rabies vaccination series. She had no history of vaccine-related rash or other adverse drug reactions, nor had she received any other drug therapy. The temporal relationship between the development of SJS and the vaccination suggests that the rabies vaccination probably was the causal agent. This case serves as a warning of a distinct cutaneous reaction of rabies vaccination. © 2018 The British Pharmacological Society.

  5. Phacoemulsification in total white cataract with Stevens-Johnson syndrome

    Directory of Open Access Journals (Sweden)

    Vasavada Abhay

    2007-01-01

    Full Text Available Cataract surgery with Stevens-Johnson syndrome (S-J is associated with a high incidence of complications and can worsen the primary disease. We report a case of phacoemulsification of a total, white cataract barely visible through the vascularized, keratinized cornea in the only seeing eye of a patient with S-J syndrome. We describe the intra-operative difficulties encountered during phacoemulsification and the surgical tools and techniques employed to overcome the surgical difficulties. The postoperative course was uneventful and the patient regained useful, navigational vision.

  6. History of the Animal Care Program at Johnson Space Center

    Science.gov (United States)

    Khan-Mayberry, Noreen; Bassett, Stephanie

    2010-01-01

    NASA has a rich history of scientific research that has been conducted throughout our numerous manned spaceflight programs. This scientific research has included animal test subjects participating in various spaceflight missions, including most recently, Space Shuttle mission STS-131. The Animal Care Program at Johnson Space Center (JSC) in Houston, Texas is multi-faceted and unique in scope compared to other centers within the agency. The animal care program at JSC has evolved from strictly research to include a Longhorn facility and the Houston Zoo's Attwater Prairie Chicken refuge, which is used to help repopulate this endangered species. JSC is home to more than 300 species of animals including home of hundreds of white-tailed deer that roam freely throughout the center which pose unique issues in regards to population control and safety of NASA workers, visitors and tourists. We will give a broad overview of our day to day operations, animal research, community outreach and protection of animals at NASA Johnson Space Center.

  7. James Weldon Johnson and the Speech Lab Recordings

    Directory of Open Access Journals (Sweden)

    Chris Mustazza

    2016-03-01

    Full Text Available On December 24, 1935, James Weldon Johnson read thirteen of his poems at Columbia University, in a recording session engineered by Columbia Professor of Speech George W. Hibbitt and Barnard colleague Professor W. Cabell Greet, pioneers in the field that became sociolinguistics. Interested in American dialects, Greet and Hibbitt used early sound recording technologies to preserve dialect samples. In the same lab where they recorded T.S. Eliot, Gertrude Stein, and others, James Weldon Johnson read a selection of poems that included several from his seminal collection God’s Trombones and some dialect poems. Mustazza has digitized these and made them publicly available in the PennSound archive. In this essay, Mustazza contextualizes the collection, considering the recordings as sonic inscriptions alongside their textual manifestations. He argues that the collection must be heard within the frames of its production conditions—especially its recording in a speech lab—and that the sound recordings are essential elements in an hermeneutic analysis of the poems. He reasons that the poems’ original topics are reframed and refocused when historicized and contextualized within the frame of The Speech Lab Recordings.

  8. Paradise and Politics in the Music of Blind Willie Johnson

    Directory of Open Access Journals (Sweden)

    Owen Coggins

    2012-05-01

    Full Text Available I investigate the politics of paradises in the 1920s African-American gospel blues of Blind Willie Johnson. His recordings are apocalyptic vignettes which juxtapose and conflate paradises, using many different voices. I describe the theological and political paradises in Johnson’s songs: the Old Testament journey to Canaan; the post-death heaven in the New Testament; Christ’s kingdom on earth in Revelation; freedom in Northern cities or Canada; and a utopian dream of political emancipation of African-Americans and transformation of society in the South. I outline the various voices present in Johnson’s recordings: vocal styles; accompanying singers; the guitar; grammatical, textual and lexical voices; and the silent voices of technology and time. I suggest traces of a subtle political activism in these voices and paradises, and explore uses of these voices in linking paradises, arguing that the complex transitions enhance the force of signification and frustrate attempts to finalise meanings. Many interpretations of Johnson’s recordings, however, seek to determine final meaning, and I discuss the limitations of such attempts, limitations which not only underestimate the richness of the recordings but deny Johnson any political awareness or agency. In cautioning against this kind of project, I call for a hearing open to plural interpretations, and suggest political potential not only in coded messages, but in radical indeterminacy itself.

  9. Stevens Johnson syndrome in Pakistan: a ten-year survey.

    Science.gov (United States)

    Ahmed, Y I; Azeem, S; Khan, O; Majid, T H; Ahmed, D; Amin, A; Mahmood, A; Hameed, K

    2004-06-01

    A pre-tested questionnaire-based, retrospective study to highlight the causative factors, mode of presentation, complications and outcome of patients with Stevens Johnson syndrome. Aga Khan University Hospital over a 10 year period. All case records with a diagnosis of Steven Johnson Syndrome in the period 1990 to 2000 were retrospectively reviewed. Data was retrieved on a comprehensive questionnaire. The demographic variatbles and drugs taken within the previous 21 days were noted. Date analysis was done by Epi-Info Version 6.0. Of the 101 studied patient files, the most common offender was found to be the Penicillins as a group and Sulfadoxine-Pyrimethamine (Fansidar) when considering all drugs individually. Most common complications included electrolyte disturbances (13.9%) and congestive heart failure (6.9%). Mortality rate was high at 10.1%. SJS was found to be a rare condition but having a mortality rate of 10.1%. As it can be induced by a large number of drugs, caution should be practiced while prescribing.

  10. [Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine].

    Science.gov (United States)

    Bocquet, H; Farmer, M; Bressieux, J M; Barzegar, C; Jullien, M; Soto, B; Roujeau, J C; Revuz, J

    1999-01-01

    Lamotrigine is a new anticonvulsant belonging to the triazine family. Several cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been described in patients taking this drug. We report 2 cases in children attending the same hospital. Two children, aged 9 and 13 years, developed SJS and TEN respectively, 3 and 28 days after lamotrigine was added to their usual anticonvulsant regimen. In both cases, outcome was favorable despite major decline in psychomotor capacity in one. In the first case, chronological attributability was plausible for lamotrigine and doubtful for sodium valproate, clonazepam and hydrocortisone. In the second case, chronological attributability was probable for amoxicillin, plausible for lamotrigine and doubtful for sodium valproate, but the numerous previous absorptions of amoxicillin made lamotrigine more suspect. The risk of Steven-Johnson syndrome and toxic epidermal necrolysis is high with lamotrigine with an estimated frequency of 1/1000. This risk is probably higher than with other anticonvulsants. Associating lamotrigine with sodium valproate increases the frequency of adverse skin reactions.

  11. Parcels and Land Ownership, Parcel boundaries for Johnson County Kansas based off of legal description. Used to show spatial reference to parcel boundaries of Johnson County Kansas., Published in 2007, Johnson County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Parcels and Land Ownership dataset current as of 2007. Parcel boundaries for Johnson County Kansas based off of legal description. Used to show spatial reference to...

  12. PLSS Townships and Sections, Sections within Johnson County. Attributes of section, township and range as well as AIMS number for easier naviation that people use within Johnson County., Published in 2007, Johnson County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — PLSS Townships and Sections dataset current as of 2007. Sections within Johnson County. Attributes of section, township and range as well as AIMS number for easier...

  13. Phenytoin induced Steven-Johnson syndrome and bronchiolitis obliterans - case report and review of literature.

    Science.gov (United States)

    Pannu, Bibek S; Egan, Ashley M; Iyer, Vivek N

    2016-01-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are both rare but serious idiosyncratic drug reactions characterized by diffuse muco-epidermoid injury and high mortality. Keratinocytes in both skin and mucous membranes (including eyes, mouth and genitalia) are injured resulting in a diffuse maculopapular rash, blistering lesions and epithelial detachment with minimal force (Nikolsky's sign). SJS is typically diagnosed when less than 10% of the skin surface is involved and the term TEN is used in cases with more than 30% involvement. Respiratory involvement in SJS-TEN is common with 30-50% of cases demonstrating respiratory epithelial sloughing with severe short and long term complications. Patients who survive SJS-TEN are often left with impaired respiratory function and bronchiolitis obliterans. Cases of bronchiolitis obliterans with SJS/TEN have been very rarely reported. We report a case of phenytoin induced SJS/TEN followed by severe bronchiolitis obliterans in an adult patient. The presentation, pathophysiology and management of SJS/TEN related bronchiolitis obliterans is also reviewed.

  14. Phenytoin induced Steven–Johnson syndrome and bronchiolitis obliterans – case report and review of literature

    Directory of Open Access Journals (Sweden)

    Bibek S. Pannu

    2016-01-01

    Full Text Available Stevens–Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are both rare but serious idiosyncratic drug reactions characterized by diffuse muco-epidermoid injury and high mortality. Keratinocytes in both skin and mucous membranes (including eyes, mouth and genitalia are injured resulting in a diffuse maculopapular rash, blistering lesions and epithelial detachment with minimal force (Nikolsky's sign. SJS is typically diagnosed when less than 10% of the skin surface is involved and the term TEN is used in cases with more than 30% involvement. Respiratory involvement in SJS-TEN is common with 30–50% of cases demonstrating respiratory epithelial sloughing with severe short and long term complications. Patients who survive SJS-TEN are often left with impaired respiratory function and bronchiolitis obliterans. Cases of bronchiolitis obliterans with SJS/TEN have been very rarely reported. We report a case of phenytoin induced SJS/TEN followed by severe bronchiolitis obliterans in an adult patient. The presentation, pathophysiology and management of SJS/TEN related bronchiolitis obliterans is also reviewed.

  15. Left atrial volume index

    DEFF Research Database (Denmark)

    Poulsen, Mikael K; Dahl, Jordi S; Henriksen, Jan Erik

    2013-01-01

    To determine the prognostic importance of left atrial (LA) dilatation in patients with type 2 diabetes (T2DM) and no history of cardiovascular disease.......To determine the prognostic importance of left atrial (LA) dilatation in patients with type 2 diabetes (T2DM) and no history of cardiovascular disease....

  16. Revisiting Johnson and Jackson boundary conditions for granular flows

    Energy Technology Data Exchange (ETDEWEB)

    Li, Tingwen; Benyahia, Sofiane

    2012-07-01

    In this article, we revisit Johnson and Jackson boundary conditions for granular flows. The oblique collision between a particle and a flat wall is analyzed by adopting the classic rigid-body theory and a more realistic semianalytical model. Based on the kinetic granular theory, the input parameter for the partial-slip boundary conditions, specularity coefficient, which is not measurable in experiments, is then interpreted as a function of the particle-wall restitution coefficient, the frictional coefficient, and the normalized slip velocity at the wall. An analytical expression for the specularity coefficient is suggested for a flat, frictional surface with a low frictional coefficient. The procedure for determining the specularity coefficient for a more general problem is outlined, and a working approximation is provided.

  17. Strontium ranelate related Stevens-Johnson syndrome: a case report.

    Science.gov (United States)

    Yang, C-Y; Chen, C-H; Wang, H-Y; Hsiao, H-L; Hsiao, Y-H; Chung, W-H

    2014-06-01

    Strontium ranelate is a relatively new medication with good safety profile for the treatment of postmenopausal osteoporosis. However, severe cutaneous adverse drug reactions have been reported, such as drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). We report the case of a 70-year-old woman who developed multiple itching erythematous macules and plaques about 1 month after beginning strontium ranelate medication. The cutaneous lesions progressed over the entire body with severe oral and ocular mucosa involvement. Probable mild SJS was diagnosed, compatible with the pathology findings, and strontium ranelate was discontinued immediately. Systemic methylprednisolone was administered to suppress the overactive immune system and ameliorate cutaneous symptoms. With early recognition and prompt treatment, the patient's prognosis was good.

  18. Stevens-Johnson syndrome associated with antimicrobial agent

    Directory of Open Access Journals (Sweden)

    Ivo Cavalcanti Pita Neto

    2008-01-01

    Full Text Available Among the severe reactions to medications, immune-mediated Mucocutaneous Disorders are widely represented. Steven-Johnson’s syndrome, or great multiform erythema, appears as a systemic disturbance, involving the skin and mucous membranes, and is related to several factors, such as, viral or bacterial infections and particularly the administration of medicines, in general painkillers and antibiotics. The objective of this article is report the onset of ulcerative vesicle –blister lesions in the regions of the lips, gums, tongue and genital mucosa membrane in a 26 year-old patient, a leukoderm man, being treated with sulfamethoxazole trimethoprim for a respiratory infection, after being diagnosed as having the Steven-Johnson syndrome. SSJ1 558187121279.

  19. Paracetamol induced Steven-Johnson syndrome: A rare case report.

    Science.gov (United States)

    Rajput, Rajan; Sagari, Shitalkumar; Durgavanshi, Astha; Kanwar, Alpana

    2015-09-01

    In the contemporary era, use of drugs is the dominant paradigm of health care. The most quotidian drug used for fever and pain is paracetamol. Although adverse reactions to paracetamol in India are rare, at times they can cause life-threatening situations. Stevens-Johnson syndrome (SJS) is one such potentially lethal adverse drug reaction. The most reported cases of analgesic-induced SJS were due to oxicams or propionic acid derivatives. There are very few detailed reports of SJS due to the use of paracetamol. We report a case of SJS, which occurred due to the use of paracetamol. The clinical features of this condition and multidisciplinary management of the patient are described in brief.

  20. Oxcarbazepine-induced Stevens-Johnson Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Lung-Chang Lin

    2009-02-01

    Full Text Available Although carbamazepine (CBZ is the most common cause of Stevens-Johnson syndrome (SJS, a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA B*1502 and CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA-B*1518/B*4001. HLA-B*1518 is a HLA-B15 variant. The genetic significance of HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further studied.

  1. Autoimmune Progesterone Dermatitis Presenting as Stevens-Johnson Syndrome.

    Science.gov (United States)

    Drayer, Sara M; Laufer, Larry R; Farrell, Maureen E

    2017-10-01

    Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression. A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. A cyclic recurrence of her symptoms was noted, and the diagnosis of autoimmune progesterone dermatitis was made by an intradermal progesterone challenge. After 48 months, she remained refractory to medical management and definitive surgical treatment with bilateral oophorectomy was performed. Autoimmune progesterone dermatitis is a challenging diagnosis owing to its rarity and variety of clinical presentations. Treatment centers on suppression of endogenous progesterone and avoidance of exogenous triggers. When these modalities fail, surgical management must be undertaken.

  2. Paracetamol induced Steven-Johnson syndrome: A rare case report

    Directory of Open Access Journals (Sweden)

    Rajan Rajput

    2015-01-01

    Full Text Available In the contemporary era, use of drugs is the dominant paradigm of health care. The most quotidian drug used for fever and pain is paracetamol. Although adverse reactions to paracetamol in India are rare, at times they can cause life-threatening situations. Stevens-Johnson syndrome (SJS is one such potentially lethal adverse drug reaction. The most reported cases of analgesic-induced SJS were due to oxicams or propionic acid derivatives. There are very few detailed reports of SJS due to the use of paracetamol. We report a case of SJS, which occurred due to the use of paracetamol. The clinical features of this condition and multidisciplinary management of the patient are described in brief.

  3. Stevens-Johnson syndrome and abuse of anabolic steroids.

    Science.gov (United States)

    Cocca, Serena; Viviano, Massimo

    2017-02-01

    Stevens-Johnson syndrome (SJS) is characterized by mucocutaneous tenderness and typical hemorrhagic erosions, erythema and epidermal detachment presenting as blisters and areas of denuded skin. SJS is often observed after drug use as well as after bacterial or viral infections. Several drugs are at high risk of inducing SJS, but there are no cases in the English literature regarding anabolic steroid use triggering SJS. In our paper, we describe a case in which use of anabolic androgenic steroids (AAS) was associated with SJS. The patient participated in competitive body-building and regularly took variable doses of AAS. Initial symptoms (headache, weakness, pharyngodynia, and fever) were ignored. After a week he presented to the Emergency Department with a burning sensation on the mouth, lips, and eyes. Painful, erythematous, maculopapular, and vesicular lesions appeared all over the body, including on the genitals. During hospitalization, he also developed a cardiac complication. The patient had not taken any drugs except AAS.

  4. Road Bridges and Culverts, Bridge dataset only includes bridges maintained by Johnson County Public Works in the unincorporated areas, Published in Not Provided, Johnson County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Road Bridges and Culverts dataset current as of unknown. Bridge dataset only includes bridges maintained by Johnson County Public Works in the unincorporated areas.

  5. Torelli groups, extended Johnson homomorphisms, and new cycles on the moduli space of curves

    DEFF Research Database (Denmark)

    Morita, Shigeyuki; Penner, Robert

    modulo N are derived for all N. Furthermore, the first Johnson homomorphism, which is defined from the classical Torelli group to the third exterior power of the homology of the surface, is shown to lift to an explicit canonical 1-cocycle of the Teichmueller space. The main tool for these results...... cocycle lifts of the higher Johnson homomorphisms....

  6. 77 FR 67397 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2012-11-09

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 10, 2012, Johnson Matthey, Inc., Pharmaceuticals Materials... Thebaine (9333) II The company plans to manufacture the listed controlled substances in bulk for...

  7. 78 FR 5499 - Manufacturer of Controlled Substances; Notice of Registration; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-01-25

    ...; Notice of Registration; Johnson Matthey, Inc. By Notice dated May 9, 2012, and published in the Federal Register on May 21, 2012, 77 FR 30026, Johnson Matthey, Inc., Custom Pharmaceuticals Department, 2003 Nolte... substance listed in schedule II. The company plans to manufacture the listed controlled substance for sale...

  8. 78 FR 15975 - Manufacturer of Controlled Substances, Notice of Registration; Johnson Matthey, Inc...

    Science.gov (United States)

    2013-03-13

    ..., Notice of Registration; Johnson Matthey, Inc., Pharmaceuticals Materials By Notice dated November 1, 2012, and published in the Federal Register on November 9, 2012, 77 FR 67397, Johnson Matthey, Inc...) II The company plans to manufacture the listed controlled substances in bulk for distribution and...

  9. 78 FR 69132 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-11-18

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 5, 2013, Johnson Matthey Inc., Custom Pharmaceuticals... Remifentanil (9739) II Sufentanil (9740) II Tapentadol (9780) II Fentanyl (9801) II The company plans to...

  10. 78 FR 69133 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-11-18

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 5, 2013, Johnson Matthey, Inc., Pharmaceuticals Materials... Methadone (9250) II Methadone intermediate (9254) II Morphine (9300) II Thebaine (9333) II The company plans...

  11. 77 FR 30026 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2012-05-21

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on March 26, 2012, Johnson Matthey, Inc., Custom Pharmaceuticals...), a basic class of controlled substance listed in schedule II. The company plans to manufacture the...

  12. 78 FR 46373 - Manufacturer of Controlled Substances; Notice of Registration; Johnson Matthey Pharmaceutical...

    Science.gov (United States)

    2013-07-31

    ...; Notice of Registration; Johnson Matthey Pharmaceutical Materials, Inc. By Notice dated March 20, 2013, and published in the Federal Register on March 28, 2013, 78 FR 19017, Johnson Matthey Pharmaceutical... (9740) II The company plans to utilize this facility to manufacture small quantities of the listed...

  13. 77 FR 30028 - Manufacturer of Controlled Substances; Notice of Registration; Johnson Matthey, Inc...

    Science.gov (United States)

    2012-05-21

    ...; Notice of Registration; Johnson Matthey, Inc., Pharmaceuticals Materials By Notice dated January 6, 2012, and published in the Federal Register on January 17, 2012, 77 FR 2324, Johnson Matthey, Inc... (9333) II The company plans to manufacture the listed controlled substances in bulk for sale to its...

  14. 78 FR 19017 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey Pharmaceutical...

    Science.gov (United States)

    2013-03-28

    ...; Notice of Application; Johnson Matthey Pharmaceutical Materials, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on November 15, 2012, Johnson... Remifentanil (9739) II Sufentanil (9740) II The company plans to utilize this facility to manufacture small...

  15. 78 FR 19016 - Importer of Controlled Substances; Notice of Registration; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-03-28

    ... Registration; Johnson Matthey, Inc. By Notice dated November 19, 2012, and published in the Federal Register on November 27, 2012, 77 FR 70824, Johnson Matthey, Inc., Pharmaceutical Materials, 2003 Nolte Drive, West... Concentrate (9670) II The company plans to import the listed controlled substances as raw materials, to be...

  16. Linking Gateway Technical College with Workforce Development: The SC Johnson-A Family Company Story.

    Science.gov (United States)

    Knudson, Edward

    2004-01-01

    Seven years ago, SC Johnson--A Family Company approached Gateway Technical College with a need to further strengthen their incumbent workforce's technical training and education. Retirements, brain drain, and competition for technical expertise were the forces driving SC Johnson to develop a comprehensive, flexible, and timely workplace education…

  17. 77 FR 16264 - Manufacturer of Controlled Substances, Notice of Registration; Johnson Matthey Pharmaceutical...

    Science.gov (United States)

    2012-03-20

    ..., Notice of Registration; Johnson Matthey Pharmaceutical Materials Inc. By Notice dated November 18, 2011, and published in the Federal Register on November 28, 2011, 76 FR 72974, Johnson Matthey... Sufentanil (9740) II The company plans to utilize this facility to manufacture small quantities of the listed...

  18. 77 FR 67676 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey Inc.

    Science.gov (United States)

    2012-11-13

    ...; Notice of Application; Johnson Matthey Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 10, 2012, Johnson Matthey Inc., Custom Pharmaceuticals... Remifentanil (9739) II Sufentanil (9740) II Fentanyl (9801) II The company plans to manufacture the listed...

  19. Quality of streams in Johnson County, Kansas, 2002--10

    Science.gov (United States)

    Rasmussen, Teresa J.; Stone, Mandy S.; Poulton, Barry C.; Graham, Jennifer L.

    2012-01-01

    Stream quality in Johnson County, northeastern Kansas, was assessed on the basis of land use, hydrology, stream-water and streambed-sediment chemistry, riparian and in-stream habitat, and periphyton and macroinvertebrate community data collected from 22 sites during 2002 through 2010. Stream conditions at the end of the study period are evaluated and compared to previous years, stream biological communities and physical and chemical conditions are characterized, streams are described relative to Kansas Department of Health and Environment impairment categories and water-quality standards, and environmental factors that most strongly correlate with biological stream quality are evaluated. The information is useful for improving water-quality management programs, documenting changing conditions with time, and evaluating compliance with water-quality standards, total maximum daily loads (TMDLs), National Pollutant Discharge Elimination System (NPDES) permit conditions, and other established guidelines and goals. Constituent concentrations in water during base flow varied across the study area and 2010 conditions were not markedly different from those measured in 2003, 2004, and 2007. Generally the highest specific conductance and concentrations of dissolved solids and major ions in water occurred at urban sites except the upstream Cedar Creek site, which is rural and has a large area of commercial and industrial land less than 1 mile upstream on both sides of the creek. The highest base-flow nutrient concentrations in water occurred downstream from wastewater treatment facilities. Water chemistry data represent base-flow conditions only, and do not show the variability in concentrations that occurs during stormwater runoff. Constituent concentrations in streambed sediment also varied across the study area and some notable changes occurred from previously collected data. High organic carbon and nutrient concentrations at the rural Big Bull Creek site in 2003 decreased

  20. Microvascular Decompression of Facial Nerve and Pexy of the Left Vertebral Artery for Left Hemifacial Spasm: 3-Dimensional Operative Video.

    Science.gov (United States)

    Cheng, Chun-Yu; Shetty, Rakshith; Martinez, Vicente; Sekhar, Laligam N

    2018-03-29

    A 73-yr-old man presented with intractable left hemifacial spasm of 4 yr duration. Brain magnetic resonance imaging showed significant compression of left facial nerve by the left vertebral artery (VA) and anterior inferior cerebellar artery (AICA).The patient underwent a left retrosigmoid craniotomy and a microvascular decompression of the cranial nerve (CN) VII. Intraoperatively, we found that the distal AICA had a protracted subarcuate extradural course.1 This was relieved by intra/extradural dissection. The left VA and the AICA loop were compressing the root exit zone of CN VII. The VA was mobilized, and pexy into the petrosal dura was done with 8-0 nylon sutures (Ethilon Nylon Suture, Ethicon Inc, a subsidiary of Johnson & Johnson, Somerville, New Jersey). Once this was done, the lateral spread disappeared.2 The AICA loop was decompressed with 2 pieces of Teflon felt (Bard PTFE felt, Bard peripheral Vascular Inc, a subsidiary of CR Bard Inc, Temp, Arizona). After this, wave V of the brainstem auditory evoked potential (BAEP) disappeared completely, with no recovery despite the application of the nicardipine on the internal auditory artery (IAA). The IAA appeared to be stretched by the microvascular decompression. Arachnoidal dissection was done to release the CN VIII and an additional felt piece was placed to elevate the AICA loop; the BAEP recovered completely. The patient had a complete disappearance of the hemifacial spasm postoperatively, and hearing was unchanged.This 3-D video shows the technical nuances of performing a vertebropexy, release of the AICA from its extradural subarcuate course, and the surgical maneuvers in the event of an unexpected change in neuromonitoring response. The suture technique of vertebropexy is preferred to a loop technique, to avoid kinking of the VA.3Informed consent was obtained from the patient prior to the surgery that included videotaping of the procedure and its distribution for educational purposes. All relevant

  1. Left heart catheterization

    Science.gov (United States)

    Catheterization - left heart ... to help guide the catheters up into your heart and arteries. Dye (sometimes called "contrast") will be ... in the blood vessels that lead to your heart. The catheter is then moved through the aortic ...

  2. Patronage power: Rural electrification, river development, and Lyndon Johnson (1937--1939)

    Science.gov (United States)

    Dusek, Paul-Michael Mays

    Few historians document Lyndon Johnson's efforts to construct a state-wide political machine at the local level early in his congressional career. The literature glorifies Johnson for hydroelectric river development and rural electrification. This thesis acknowledges the transformative nature of rural electrification in Central Texas through the efforts of Johnson but, more importantly, reveals how extensively Johnson sought to capitalize on the tail-end of the New Deal to utilize government-funded relief projects to establish a state-wide political machine. An analysis of the correspondence between Johnson, his local political operators, members of his state-wide network, and rural constituents reveals another layer to the complexity of Johnson and further exposes his ambitious, calculating nature. Johnson used rural electrification to first create a community of supporters in his congressional district then used rural electrification and multipurpose river development programs to cultivate political contacts across the state of Texas. This thesis explores the first time that Lyndon Johnson used patronage to develop a political community as a publicly elected official. Johnson pushed for constant expansion of operations to ensure a steady supply of new jobs while displaying a cavalier attitude about specific regulations regarding the allocation of funds. His machine manipulated and massaged congressional appropriations restrictions and utilized multiple congressional revenue streams to stretch finances further and lower overhead costs to increase the scope of operations thus further improving the lives of his constituents. Johnson also used this movement to efficiently and effectively construct a foundation for his political machine. This thesis also clarifies an early moment in Johnson's beliefs about civil rights. Instead of standing on principle, Johnson relied on extortion and threats to fight racism at this early juncture in his political career because of

  3. Johnson Creek Artificial Propagation and Enhancement Project Operations and Maintenance Program; Brood Year 1998: Johnson Creek Chinook Salmon Supplementation, Biennial Report 1998-2000.

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, Mitch; Gebhards, John

    2003-05-01

    The Nez Perce Tribe, through funding provided by the Bonneville Power Administration, has implemented a small scale chinook salmon supplementation program on Johnson Creek, a tributary in the South Fork of the Salmon River, Idaho. The Johnson Creek Artificial Propagation Enhancement project was established to enhance the number of threatened Snake River summer chinook salmon (Oncorhynchus tshawytscha) returning to Johnson Creek through artificial propagation. Adult chinook salmon collection and spawning began in 1998. A total of 114 fish were collected from Johnson Creek and 54 fish (20 males and 34 females) were retained for Broodstock. All broodstock were transported to Lower Snake River Compensation Plan's South Fork Salmon River adult holding and spawning facility, operated by the Idaho Department of Fish and Game. The remaining 60 fish were released to spawn naturally. An estimated 155,870 eggs from Johnson Creek chinook spawned at the South Fork Salmon River facility were transported to the McCall Fish Hatchery for rearing. Average fecundity for Johnson Creek females was 4,871. Approximately 20,500 eggs from females with high levels of Bacterial Kidney Disease were culled. This, combined with green-egg to eyed-egg survival of 62%, resulted in about 84,000 eyed eggs produced in 1998. Resulting juveniles were reared indoors at the McCall Fish Hatchery in 1999. All of these fish were marked with Coded Wire Tags and Visual Implant Elastomer tags and 8,043 were also PIT tagged. A total of 78,950 smolts were transported from the McCall Fish Hatchery and released directly into Johnson Creek on March 27, 28, 29, and 30, 2000.

  4. Frequency-response mismatch effects in Johnson noise thermometry

    Science.gov (United States)

    White, D. R.; Qu, J.-F.

    2018-02-01

    Johnson noise thermometry is of considerable interest at present due to the planned redefinition of the kelvin in 2019, and several determinations of the Boltzmann constant have recently been published in support of the redefinition. To determine the Boltzmann constant by noise thermometry, the thermal noise from a sensing resistor at the triple point of water is compared to a pseudo-random noise with a calculable power spectral density traceable to quantum electrical standards. In all the measurements to date, the two dominant sources of measurement uncertainty are strongly influenced by a single factor: the frequency-response mismatch between the sets of leads connecting the thermometer to the two noise sources. In the most recent determination at the National Institute of Metrology, China, substantial changes were made to the connecting leads to reduce the mismatch effects. The aims of this paper are, firstly, to describe and explain the rationale for the changes, and secondly, to better understand the effects of the least-squares fits and the bias-variance compromise in the analysis of measurements affected by the mismatch effects. While significant improvements can be made to the connecting leads to lessen the effects of the frequency-response mismatch, the efforts are unlikely to be rewarded by a significant increase in bandwidth or a significant reduction in uncertainty.

  5. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review

    Directory of Open Access Journals (Sweden)

    Anthony Wong

    Full Text Available SUMMARY Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are uncommon, acute and potentially life-threatening adverse cutaneous drug reactions. These pathologies are considered a hypersensitivity reaction and can be triggered by drugs, infections and malignancies. The drugs most often involved are allopurinol, some antibiotics, including sulfonamides, anticonvulsants such as carbamazepine, and some non-steroid anti-inflammatory drugs (NSAIDs. Necrosis of keratinocytes is manifested clinically by epidermal detachment, leading to scalded skin appearance. The rash begins on the trunk with subsequent generalization, usually sparing the palmoplantar areas. Macular lesions become purplish, and epidermal detachment occurs, resulting in flaccid blisters that converge and break, resulting in extensive sloughing of necrotic skin. Nikolsky's sign is positive in perilesional skin. SJS and TEN are considered to be two ends of the spectrum of one disease, differing only by their extent of skin detachment. Management of patients with SJS or TEN requires three measures: removal of the offending drug, particularly drugs known to be high-risk; supportive measures and active interventions. Early diagnosis of the disease, recognition of the causal agent and the immediate withdrawal of the drug are the most important actions, as the course of the disease is often rapid and fatal.

  6. Steven johnsons syndrome and toxic epidermal necrolysis: A review

    Directory of Open Access Journals (Sweden)

    Sri ram Anne

    2014-12-01

    Full Text Available Toxic epidermal necrolysis (TEN and Stevens Johnson Syndrome (SJS are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the etiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP, disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS. Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, identification and interruption of the culprit drug, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents such as high-dose intravenous immunoglobulin therapy.

  7. Testing Johnson's typology: is there gender symmetry in intimate terrorism?

    Science.gov (United States)

    Jasinski, Jana; Blumenstein, Lindsey; Morgan, Rachel

    2014-01-01

    Despite the vast literature on gender symmetry in the perpetration of domestic assault, few studies have looked specifically at both the female and male victims of violence. Using data from the National Violence Against Women Survey (NVAWS) and building on the work of Johnson and Leone (2005), this study is a comparison of the female and male victims of intimate terrorism (IT) and an examination of the effects of IT on male victims. The findings indicate that IT, as a type of violence, does not have the same characteristics when the victims are men. Men involved in a terroristic marriage are not more likely to be injured, do not miss work more frequently, and are not more likely to report symptoms of depression compared to men involved in situational couple violence (SCV). Other findings appear to point to gender symmetry between women and men regarding IT, although broad conclusions based on these findings cannot be made in the absence of a sufficient means to measure the level of coercion within the relationship. Additional research is needed with more innovative and complete measures of control, the defining characteristic of IT.

  8. Johnson-McMillin microtia syndrome: New additional family

    Directory of Open Access Journals (Sweden)

    Nagwa Abdel-Meguid

    2014-01-01

    Full Text Available Microtia is a congenital anomaly that is found with different prevalence among various populations. The exact etiology of ear anomalies is still unknown. We describe a new additional family with this rare disorder; Johnson-McMillin syndrome (JMS where mother, son, and distant grandmother have multiple features of JMS in the form of microtia, facial asymmetry, ear malformation, hearing defect, and hypotrichosis. Variable presentations in this family could be referred to phenotype variation supporting an autosomal dominant pattern of inheritance. We observed that the mother was very sad and suffered from feelings of guilt. We found that she had isolated herself from family and community out of fear of being stigmatized and hurt. We concluded that the occurrence of microtia is of public health importance, adhering to traditional marriage customs in Egypt increases women′s risk of giving birth to a disabled child, yet the mothers are blamed and shamed for their children′s birth defects by their husbands, families, and communities, while the fathers are not stigmatized.

  9. Evanescent-wave Johnson noise in small devices

    Science.gov (United States)

    Premakumar, Vickram N.; Vavilov, Maxim G.; Joynt, Robert

    2018-01-01

    In many quantum computer architectures, the qubits are in close proximity to metallic device elements. The fluctuating currents in the metal give rise to noisy electromagnetic fields that leak out into the surrounding region. These fields are known as evanescent-wave Johnson noise. The noise can decohere the qubits. We review and update the general theory of this effect for charge qubits subject to electric noise and for spin and magnetic qubits subject to magnetic noise. A mapping of the quantum-mechanical problem onto a problem in classical electrodynamics simplifies the calculations. The focus is on relatively simple geometries in which analytical calculations can be done. Results are presented for the local noise spectral density in the vicinity of cylindrical conductors such as small antennae, noise from objects that can be treated as dipoles, and noise correlation functions for several geometries. We summarize the current state of the comparison of theory with experimental results on decoherence times of qubits. Emphasis is placed on qualitative understanding of the basic concepts and phenomena.

  10. Erythema multiforme and Stevens-Johnson syndrome following radiotherapy

    International Nuclear Information System (INIS)

    Yoshitake, Tadamasa; Nakamura, Katsumasa; Shioyama, Yoshiyuki

    2007-01-01

    Erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) are thought to be hypersensitivity syndromes with various causes, and radiotherapy might be one of the causes of these syndromes. We herein report two cases of EM/SJS following radiotherapy. The first case was a 63-year-old woman with breast cancer. At the end of postoperative radiotherapy with 60 Gy, severe pruritic erythema appeared in the irradiated area and spread over the whole body. She was diagnosed with EM by a skin biopsy. The second case was a 77-year-old woman with uterine cervical cancer who underwent postoperative radiotherapy. At a dose of 30.6 Gy, pruritic redness appeared in the irradiated area and the precordial region, and it became widespread rapidly with polymorphic transformation. Although without any histological confirmation, SJS was strongly suspected because of her pruritic conjunctivitis. Because both patients were given medicines during irradiation, radiotherapy may not be the only cause of EM/SJS. However, it should be noted that radiotherapy might trigger EM/SJS. (author)

  11. Erythema multiforme and Stevens-Johnson syndrome following radiotherapy.

    Science.gov (United States)

    Yoshitake, Tadamasa; Nakamura, Katsumasa; Shioyama, Yoshiyuki; Sasaki, Tomonari; Ooga, Saiji; Abe, Madoka; Urashima, Yusuke; Urabe, Kazunori; Terashima, Hiromi; Honda, Hiroshi

    2007-01-01

    Erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) are thought to be hypersensitivity syndromes with various causes, and radiotherapy might be one of the causes of these syndromes. We herein report two cases of EM/SJS following radiotherapy. The first case was a 63-year-old woman with breast cancer. At the end of postoperative radiotherapy with 60 Gy, severe pruritic erythema appeared in the irradiated area and spread over the whole body. She was diagnosed with EM by a skin biopsy. The second case was a 77-year-old woman with uterine cervical cancer who underwent postoperative radiotherapy. At a dose of 30.6 Gy, pruritic redness appeared in the irradiated area and the precordial region, and it became widespread rapidly with polymorphic transformation. Although without any histological confirmation, SJS was strongly suspected because of her pruritic conjunctivitis. Because both patients were given medicines during irradiation, radiotherapy may not be the only cause of EM/SJS. However, it should be noted that radiotherapy might trigger EM/SJS.

  12. Steven-Johnson Syndrome (SJS and Toxic Epidermal Necrolysis

    Directory of Open Access Journals (Sweden)

    Erkan Alpsoy

    2010-12-01

    Full Text Available Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are rare, life-threatening conditions with a high mortality rate. SJS and TEN are used to denote a group of disorders closely related to each other, characterized by extensive epidermal necrolysis, and usually induced by drugs. Keratinocyte apoptosis is the main reason for widespread epidermal detachment. Drugs or their methobolites can act as a hapten after binding to the keratinocyte surface and initiate cytotoxic immunological attack. Drug-specific CD8+cytotoxic T cells mediate keratinocyte apoptosis by the Fas/FasL pathway and perforin/granzyme pathway. Although numerous drugs have been noted as responsible, sulfonamide class of antibiotics, anticonvulsants, beta-lactam antibiotics, allopurinol, nonsteroidal anti-inflammatory drugs, nevirapine and thiacetazone are the most frequently reported causative ones. Early diagnosis and withdrawal of suspected drug or drugs are one of the most important steps in the treatment. Other diseases resembling SJS/TEN should be excluded as soon as possible. Although various topical and systemic treatments have recently been used, ideal supportive care is still the most important and effective therapeutic approach. SCORTEN, a scoring system used to predict mortality in TEN, has been widely used in recent years. Transfer to a burn unit or intensive care unit is recommended for patients with a SCORTEN 3 (mortality rate; 35.3% or over. In this paper, we aimed to review clinical findings, aetiopathogenesis and treatment of these syndromes in the light of current literature.

  13. NASA Johnson Space Center SBIR STTR Program Technology Innovations

    Science.gov (United States)

    Krishen, Kumar

    2007-01-01

    The Small Business Innovation Research (SBIR) Program increases opportunities for small businesses to participate in research and development (R&D), increases employment, and improves U.S. competitiveness. Specifically the program stimulates U.S. technological innovation by using small businesses to meet federal R&D needs, increasing private-sector commercialization of innovations derived from federal R&D, and fostering and encouraging the participation of socially disadvantaged businesses. In 2000, the Small Business Technology Transfer (STTR) Program extended and strengthened the SBIR Program, increasing its emphasis on pursuing commercial applications by awarding contracts to small business concerns for cooperative R&D with a nonprofit research institution. Modeled after the SBIR Program, STTR is nevertheless a separately funded activity. Technologies that have resulted from the Johnson Space Center SBIR STTR Program include: a device for regenerating iodinated resin beds; laser-assisted in-situ keratomileusis or LASIK; a miniature physiological monitoring device capable of collecting and analyzing a multitude of real-time signals to transmit medical data from remote locations to medical centers for diagnosis and intervention; a new thermal management system for fibers and fabrics giving rise to new line of garments and thermal-enhancing environments; and a highly electropositive material that attracts and retains electronegative particles in water.

  14. Stevens-Johnson syndrome: The role of an ophthalmologist.

    Science.gov (United States)

    Jain, Rajat; Sharma, Namrata; Basu, Sayan; Iyer, Geetha; Ueta, Mayumi; Sotozono, Chie; Kannabiran, Chitra; Rathi, Varsha M; Gupta, Nidhi; Kinoshita, Shigeru; Gomes, José A P; Chodosh, James; Sangwan, Virender S

    2016-01-01

    Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. Acute SJS leads to the acute inflammation of the ocular surface and chronic conjunctivitis. If not properly treated, it causes chronic cicatricial conjunctivitis and cicatricial lid margin abnormalities. Persistent inflammation and ulceration of the ocular surface with cicatricial complications of the lids leads to chronic ocular sequelae, ocular surface damage, and corneal scarring. The destruction of the glands that secrete the tear film leads to a severe form of dry eye that makes the management of chronic SJS difficult. The option that is routinely used for corneal visual rehabilitation, keratoplasty, is best avoided in such cases. We describe the management strategies that are most effective during the acute and chronic stages of SJS. Although treatments for acute SJS involve immunosuppressive and immunomodulatory therapies, amniotic membrane transplantation is also useful. The options for visual rehabilitation in patients with chronic SJS are undergoing radical change. We describe the existing literature regarding the management of SJS and highlight recent advances in the management of this disorder. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Johnson-McMillin Microtia Syndrome: New Additional Family.

    Science.gov (United States)

    Abdel-Meguid, Nagwa; Gebril, Ola Hosny; Abdelraouf, Ehab Ragaa; Shafie, Mohammed Akmal; Bahgat, Mohammed

    2014-07-01

    Microtia is a congenital anomaly that is found with different prevalence among various populations. The exact etiology of ear anomalies is still unknown. We describe a new additional family with this rare disorder; Johnson-McMillin syndrome (JMS) where mother, son, and distant grandmother have multiple features of JMS in the form of microtia, facial asymmetry, ear malformation, hearing defect, and hypotrichosis. Variable presentations in this family could be referred to phenotype variation supporting an autosomal dominant pattern of inheritance. We observed that the mother was very sad and suffered from feelings of guilt. We found that she had isolated herself from family and community out of fear of being stigmatized and hurt. We concluded that the occurrence of microtia is of public health importance, adhering to traditional marriage customs in Egypt increases women's risk of giving birth to a disabled child, yet the mothers are blamed and shamed for their children's birth defects by their husbands, families, and communities, while the fathers are not stigmatized.

  16. A Boltzmann constant determination based on Johnson noise thermometry

    Science.gov (United States)

    Flowers-Jacobs, N. E.; Pollarolo, A.; Coakley, K. J.; Fox, A. E.; Rogalla, H.; Tew, W. L.; Benz, S. P.

    2017-10-01

    A value for the Boltzmann constant was measured electronically using an improved version of the Johnson Noise Thermometry (JNT) system at the National Institute of Standards and Technology (NIST), USA. This system is different from prior ones, including those from the 2011 determination at NIST and both 2015 and 2017 determinations at the National Institute of Metrology (NIM), China. As in all three previous determinations, the main contribution to the combined uncertainty is the statistical uncertainty in the noise measurement, which is mitigated by accumulating and integrating many weeks of cross-correlated measured data. The second major uncertainty contribution also still results from variations in the frequency response of the ratio of the measured spectral noise of the two noise sources, the sense resistor at the triple-point of water and the superconducting quantum voltage noise source. In this paper, we briefly describe the major differences between our JNT system and previous systems, in particular the input circuit and approach we used to match the frequency responses of the two noise sources. After analyzing and integrating 50 d of accumulated data, we determined a value: k~=1.380 642 9(69)× {{10}-23} J K-1 with a relative standard uncertainty of 5.0× {{10}-6} and relative offset -4.05× {{10}-6} from the CODATA 2014 recommended value.

  17. Fonograma 108.077: o lundu de George W. Johnson Phonogram 108.077 (Brazilian Odeon: George W. Johnson's lundum

    Directory of Open Access Journals (Sweden)

    Carlos Palombini

    2011-06-01

    Full Text Available Um exame do fonograma Gargalhada (pega na chaleira, cançoneta por Eduardo das Neves, expõe a origem da expressão "pegar na chaleira" e revela incongruências nos critérios de catalogação online do Instituto Moreira Salles. Provavelmente datada de 1906, a gravação aparece como um "lundu" em catálogos comerciais de 1915-1926, e as mesmas ideias musicais foram reaproveitadas em outros registros sonoros da Casa Edison comercializados entre 1913 e 1919. A música e o gargalhar que Neves reaproveita foram criados por George Washington Johnson, o primeiro astro negro da gravação mecânica. Mas enquanto o ex-escravo norte-americano se auto-ridiculariza de acordo com estereótipos brancos, o autodenominado "crioulo" encena uma sátira ao comportamento masculino das classes dominantes do Rio. Neste processo, a coon song transforma-se na antítese do gênero.Through an examination of the phonogram Gargalhada (pega na chaleira [laughter (picking up the kettle], chansonnette sung by Eduardo das Neves, the origin of the expression "pegar na chaleira" (bootlicking emerges, together with incongruities in the Instituto Moreira Salles online catalogue. Probably recorded in 1906, six years before the establishment of the Odeon plant in Rio, the piece was labelled as a lundum, a paradigmatically Afro-Brazilian genre, in the 1915-1926 catalogues. The music and laughter that Neves appropriates to himself were created by George W. Johnson, the first black star of early phonography, and reused in other Casa Edison (Brazilian Odeon recordings on sale from 1913 to 1919. But while the former North American slave ridicules himself in accordance with white stereotypes, the self-designated crioulo stages a satire on the behaviour of upper-class Rio de Janeiro males. In this process, the coon song turns into its antithesis.

  18. 77 FR 9969 - Johnson Controls D/B/A Hoover Universal, Inc. Including On-Site Leased Workers from Kelly...

    Science.gov (United States)

    2012-02-21

    ... automobiles. The company reports that in the state of Illinois, Johnson Controls and Hoover Universal, Inc... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,074] Johnson Controls D/B/A... Johnson Controls, including on-site leased workers from Kelly Services, Sycamore, Illinois. The notice was...

  19. STEVENS JOHNSON SYNDROME DURING TREATMENT WITH LITHIUM AND VALPROATE IN MOOD DISORDER: A REPORT OF TWO CASES

    OpenAIRE

    Misra, B.N.; Mohapatra, P.K.; Roy, D.

    2002-01-01

    Very rarely Stevens Johnson Syndrome develops following drug therapy particularly Lithium and Valproate. Worldwide, the reports regarding Lithium and Valproate induced Stevens Johnson Syndrome are very few. Here, we present two cases of Stevens Johnson Syndrome following treatment with Lithium and Valproate for Mood Disorder.

  20. 99mTc-HIDA cholescintigraphy in Dubin-Johnson and Rotor syndromes

    International Nuclear Information System (INIS)

    Bar-Meir, S.; Baron, J.; Seligson, U.; Gottesfeld, F.; Levy, R.; Gilat, T.

    1982-01-01

    99mTc-HIDA cholescintigraphy was performed in 6 patients with Dubin-Johnson syndrome and 1 patient with Rotor syndrome. In the patients with Dubin-Johnson syndrome, the cholescintigrams had a characteristic pattern of delayed visualization or nonvisualization of the gallbladder and bile ducts in the presence of intense, homogeneous, and prolonged visualization of the liver. In the patient with Rotor syndrome, the hepatobiliary system was not visualized at all. It is concluded that 99mTc-HIDA cholescintigraphy may be helpful in the diagnosis of Dubin-Johnson syndrome and Rotor syndrome and in the differential diagnosis between these two conditions

  1. Brood Year 2004: Johnson Creek Chinook Salmon Supplementation Report, June 2004 through March 2006.

    Energy Technology Data Exchange (ETDEWEB)

    Gebhards, John S.; Hill, Robert; Daniel, Mitch [Nez Perce Tribe

    2009-02-19

    The Nez Perce Tribe, through funding provided by the Bonneville Power Administration, has implemented a small scale chinook salmon supplementation program on Johnson Creek, a tributary in the South Fork of the Salmon River, Idaho. The Johnson Creek Artificial Propagation Enhancement project was established to enhance the number of threatened Snake River spring/summer chinook salmon (Oncorhynchus tshawytscha) returning to Johnson Creek to spawn through artificial propagation. This was the sixth season of adult chinook broodstock collection in Johnson Creek following collections in 1998, 2000, 2001, 2002, and 2003. Weir installation was completed on June 21, 2004 with the first chinook captured on June 22, 2004 and the last fish captured on September 6, 2004. The weir was removed on September 18, 2004. A total of 338 adult chinook, including jacks, were captured during the season. Of these, 211 were of natural origin, 111 were hatchery origin Johnson Creek supplementation fish, and 16 were adipose fin clipped fish from other hatchery operations and therefore strays into Johnson Creek. Over the course of the run, 57 natural origin Johnson Creek adult chinook were retained for broodstock, transported to the South Fork Salmon River adult holding and spawning facility and held until spawned. The remaining natural origin Johnson Creek fish along with all the Johnson Creek supplementation fish were released upstream of the weir to spawn naturally. Twenty-seven Johnson Creek females were artificially spawned with 25 Johnson Creek males. Four females were diagnosed with high bacterial kidney disease levels resulting in their eggs being culled. The 27 females produced 116,598 green eggs, 16,531 green eggs were culled, with an average eye-up rate of 90.6% resulting in 90,647 eyed eggs. Juvenile fish were reared indoors at the McCall Fish Hatchery until November 2005 and then transferred to the outdoor rearing facilities during the Visual Implant Elastomer tagging operation

  2. Elimination of noise peak for signal processing in Johnson noise thermometry development

    International Nuclear Information System (INIS)

    Hwang, I. G.; Moon, B. S.; Jeong, J. E.; Jeo, Y. H.; Kisner, Roger A.

    2003-01-01

    The internal and external noise is the most considering obstacle in development of Johnson Noise Thermometry system. This paper addresses an external noise elimination issue of the Johnson Noise Thermometry system which is underway of development in collaboration between KAERI and ORNL. Although internal random noise is canceled by Cross Power Spectral Density function, a continuous wave penetrating into the electronic circuit is eliminated by the difference of peaks between Johnson signal and external noise. The elimination logic using standard deviation of CPSD and energy leakage problem in discrete CPSD function are discussed in this paper

  3. Mycoplasma pneumoniae and atypical Stevens-Johnson syndrome: a case series.

    Science.gov (United States)

    Ravin, Karen A; Rappaport, Lara D; Zuckerbraun, Noel S; Wadowsky, Robert M; Wald, Ellen R; Michaels, Marian M

    2007-04-01

    Mycoplasma pneumoniae is a common cause of community-acquired respiratory illness in the adolescent population. Stevens-Johnson syndrome is an extrapulmonary manifestation that has been associated with M. pneumoniae infections. Three adolescent males presented within a 1-month period with M. pneumoniae respiratory illnesses and severe mucositis but without the classic rash typical of Stevens-Johnson. Diagnosis was facilitated by the use of a polymerase chain reaction-based assay. This case series highlights the potential for M. pneumoniae-associated Stevens-Johnson syndrome to occur without rash and supports the use of polymerase chain reaction for early diagnosis.

  4. /sup 99m/Tc-HIDA cholescintigraphy in Dubin-Johnson and Rotor syndromes

    International Nuclear Information System (INIS)

    Bar-Meir; Baron, J.; Seligson, U.; Gottesfeld, F.; Levy, R.; Gilat, T.

    1982-01-01

    /sup 99m/Tc-HIDA cholescintigraphy was performed in 6 patients with Dubin-Johnson syndrome and 1 patient with Rotor syndrome. In the patients with Dubin-Johnson syndrome, the cholescintigrams had a characteristic pattern of delayed visualization or nonvisualization of the gallbladder and bile ducts in the presence of intense, homogeneous, and prolonged visualization of the liver. In the patient with Rotor syndrome, the hepatobiliary system was not visualized at all. It is concluded that /sup 99m/Tc-HIDA cholescintigraphy may be helpful in the diagnosis of Dubin-Johnson syndrome and Rotor syndrome and in the differential diagnosis between these two conditions

  5. [Recurrent left atrial myxoma].

    Science.gov (United States)

    Moreno Martínez, Francisco L; Lagomasino Hidalgo, Alvaro; Mirabal Rodríguez, Roger; López Bermúdez, Félix H; López Bernal, Omaida J

    2003-01-01

    Primary cardiac tumors are rare. Mixomas are the most common among them; 75% are located in the left atrium, 20% in the right atrium, and the rest in the ventricles. The seldom appear in atrio-ventricular valves. Recidivant mixoma are also rare, appearing in 1-5% of all patients that have undergone surgical treatment of a mixoma. In this paper we present our experience with a female patient, who 8 years after having been operated of a left atrial mixoma, began with symptoms of mild heart failure. Transthoracic echocardiography revealed recurrence of the tumor, and was therefore subjected to a second open-heart surgery from which she recovered without complications.

  6. Climate Change Adaptation Science Activities at NASA Johnson Space Center

    Science.gov (United States)

    Stefanov, William L.; Lulla, Kamlesh

    2012-01-01

    The Johnson Space Center (JSC), located in the southeast metropolitan region of Houston, TX is the prime NASA center for human spaceflight operations and astronaut training, but it also houses the unique collection of returned extraterrestrial samples, including lunar samples from the Apollo missions. The Center's location adjacent to Clear Lake and the Clear Creek watershed, an estuary of Galveston Bay, puts it at direct annual risk from hurricanes, but also from a number of other climate-related hazards including drought, floods, sea level rise, heat waves, and high wind events all assigned Threat Levels of 2 or 3 in the most recent NASA Center Disaster/Risk Matrix produced by the Climate Adaptation Science Investigator Working Group. Based on prior CASI workshops at other NASA centers, it is recognized that JSC is highly vulnerable to climate-change related hazards and has a need for adaptation strategies. We will present an overview of prior CASI-related work at JSC, including publication of a climate change and adaptation informational data brochure, and a Resilience and Adaptation to Climate Risks Workshop that was held at JSC in early March 2012. Major outcomes of that workshop that form a basis for work going forward are 1) a realization that JSC is embedded in a regional environmental and social context, and that potential climate change effects and adaptation strategies will not, and should not, be constrained by the Center fence line; 2) a desire to coordinate data collection and adaptation planning activities with interested stakeholders to form a regional climate change adaptation center that could facilitate interaction with CASI; 3) recognition that there is a wide array of basic data (remotely sensed, in situ, GIS/mapping, and historical) available through JSC and other stakeholders, but this data is not yet centrally accessible for planning purposes.

  7. Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome

    Science.gov (United States)

    Low, Yen S; Caster, Ola; Bergvall, Tomas; Fourches, Denis; Zang, Xiaoling; Norén, G Niklas; Rusyn, Ivan; Edwards, Ralph

    2016-01-01

    Objective Quantitative Structure-Activity Relationship (QSAR) models can predict adverse drug reactions (ADRs), and thus provide early warnings of potential hazards. Timely identification of potential safety concerns could protect patients and aid early diagnosis of ADRs among the exposed. Our objective was to determine whether global spontaneous reporting patterns might allow chemical substructures associated with Stevens-Johnson Syndrome (SJS) to be identified and utilized for ADR prediction by QSAR models. Materials and Methods Using a reference set of 364 drugs having positive or negative reporting correlations with SJS in the VigiBase global repository of individual case safety reports (Uppsala Monitoring Center, Uppsala, Sweden), chemical descriptors were computed from drug molecular structures. Random Forest and Support Vector Machines methods were used to develop QSAR models, which were validated by external 5-fold cross validation. Models were employed for virtual screening of DrugBank to predict SJS actives and inactives, which were corroborated using knowledge bases like VigiBase, ChemoText, and MicroMedex (Truven Health Analytics Inc, Ann Arbor, Michigan). Results We developed QSAR models that could accurately predict if drugs were associated with SJS (area under the curve of 75%–81%). Our 10 most active and inactive predictions were substantiated by SJS reports (or lack thereof) in the literature. Discussion Interpretation of QSAR models in terms of significant chemical descriptors suggested novel SJS structural alerts. Conclusions We have demonstrated that QSAR models can accurately identify SJS active and inactive drugs. Requiring chemical structures only, QSAR models provide effective computational means to flag potentially harmful drugs for subsequent targeted surveillance and pharmacoepidemiologic investigations. PMID:26499102

  8. Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome.

    Science.gov (United States)

    Low, Yen S; Caster, Ola; Bergvall, Tomas; Fourches, Denis; Zang, Xiaoling; Norén, G Niklas; Rusyn, Ivan; Edwards, Ralph; Tropsha, Alexander

    2016-09-01

    Quantitative Structure-Activity Relationship (QSAR) models can predict adverse drug reactions (ADRs), and thus provide early warnings of potential hazards. Timely identification of potential safety concerns could protect patients and aid early diagnosis of ADRs among the exposed. Our objective was to determine whether global spontaneous reporting patterns might allow chemical substructures associated with Stevens-Johnson Syndrome (SJS) to be identified and utilized for ADR prediction by QSAR models. Using a reference set of 364 drugs having positive or negative reporting correlations with SJS in the VigiBase global repository of individual case safety reports (Uppsala Monitoring Center, Uppsala, Sweden), chemical descriptors were computed from drug molecular structures. Random Forest and Support Vector Machines methods were used to develop QSAR models, which were validated by external 5-fold cross validation. Models were employed for virtual screening of DrugBank to predict SJS actives and inactives, which were corroborated using knowledge bases like VigiBase, ChemoText, and MicroMedex (Truven Health Analytics Inc, Ann Arbor, Michigan). We developed QSAR models that could accurately predict if drugs were associated with SJS (area under the curve of 75%-81%). Our 10 most active and inactive predictions were substantiated by SJS reports (or lack thereof) in the literature. Interpretation of QSAR models in terms of significant chemical descriptors suggested novel SJS structural alerts. We have demonstrated that QSAR models can accurately identify SJS active and inactive drugs. Requiring chemical structures only, QSAR models provide effective computational means to flag potentially harmful drugs for subsequent targeted surveillance and pharmacoepidemiologic investigations. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association.

  9. Outbreak of Mycoplasma pneumoniae–Associated Stevens-Johnson Syndrome

    Science.gov (United States)

    Watkins, Louise K. Francois; Demirjian, Alicia; Lin, Xia; Robinson, Christine C.; Pretty, Kristin; Benitez, Alvaro J.; Winchell, Jonas M.; Diaz, Maureen H.; Miller, Lisa A.; Foo, Teresa A.; Mason, Melanie D.; Lauper, Ursula L.; Kupfer, Oren; Kennedy, Jeffrey; Glodé, Mary P.; Kutty, Preeta K.; Dominguez, Samuel R.

    2015-01-01

    BACKGROUND: Stevens-Johnson syndrome (SJS) is an uncommon, sporadic disease and outbreaks are rare. In November 2013, an outbreak of SJS was identified at Children’s Hospital Colorado. METHODS: Outbreak cases were children aged 5–21 with a discharge diagnosis of SJS admitted from September 1 to November 30, 2013. Medical charts were reviewed using standardized data collection forms. Respiratory specimens were tested for viruses and Mycoplasma pneumoniae (Mp) by polymerase chain reaction (PCR). We conducted a separate 4-year retrospective case-control study comparing hospitalized SJS cases with and without evidence of Mp infection. RESULTS: During the outbreak, 8 children met SJS criteria. Median age was 11.5 years (range 8–16 years); 5 (63%) were boys and 5 (63%) were Mp-PCR–positive. Of the 5 PCR-positive children, none had preceding medication exposure, and all had radiographic pneumonia. All outbreak Mp isolates were macrolide susceptible. The retrospective case-control analysis showed that Mp-associated SJS episodes (n = 17) were more likely to have pneumonia (odds ratio [OR] 10.0, confidence interval [CI] 1.3–5.1), preceding respiratory symptoms (OR 30.0, CI 1.6–72.6), an erythrocyte sedimentation rate ≥35 mg/dL (OR 22.8, CI 2.1–244.9), and ≤3 affected skin sites (OR 4.5, CI 1.2–17.4) than non–Mp-associated SJS episodes (n = 23). CONCLUSIONS: We report the largest outbreak of SJS in children, which was also predominately associated with Mp infection. Mp-associated SJS was associated with a distinct clinical presentation that included less extensive skin disease, an elevated erythrocyte sedimentation rate, and evidence of a preceding respiratory infection. PMID:26216320

  10. Corporate social responsibility in public health: A case-study on HIV/AIDS epidemic by Johnson & Johnson company in Africa.

    Science.gov (United States)

    Chattu, Vijay Kumar

    2015-01-01

    HIV/AIDS has claimed millions of lives in the global workforce and continues to remain a threat to many businesses. An estimated 36.5 million of working people are living with HIV; the global workforce has lost 28 million people from AIDS since the beginning of the epidemic. In the absence of access to treatment, this number could grow to 74 million by 2015. The epidemic continues to affect the working population through absenteeism, sickness and death. Corporate Social Responsibility (CSR) is an obligation that corporates have toward their employees, community and society. A review and documentation of one such CSR by Johnson & Johnson (a multinational company) for HIV/AIDS in Africa is presented here. Johnson & Johnson Company is involved in numerous projects around the world to combat the HIV/AIDS epidemic. The company is working to fight the spread of the disease and improve the quality of life for those living with the illness through various donations of its products and sponsorship of local programs. This case study also highlights different categories of CSR activities such as Cause Promotion, Cause related Marketing, Corporate Philanthropy, Corporate Social Marketing, Corporate Volunteering and Socially responsible business practices, which are discussed with specific examples from different countries in Africa. CSR of any business encompasses the economic, legal, ethical & discretionary expectation placed on the organization by society at a given point of time. CSR is therefore the obligation that corporations have toward their stakeholders and society in general which horizons beyond what is prescribed by law or union contracts. Johnson & Johnson has a proved history of being committed to caring for people and a good example of a company with a long history of citizenship and sustainability.

  11. Left atrial appendage occlusion

    Directory of Open Access Journals (Sweden)

    Ahmad Mirdamadi

    2013-01-01

    Full Text Available Left atrial appendage (LAA occlusion is a treatment strategy to prevent blood clot formation in atrial appendage. Although, LAA occlusion usually was done by catheter-based techniques, especially percutaneous trans-luminal mitral commissurotomy (PTMC, it can be done during closed and open mitral valve commissurotomy (CMVC, OMVC and mitral valve replacement (MVR too. Nowadays, PTMC is performed as an optimal management of severe mitral stenosis (MS and many patients currently are treated by PTMC instead of previous surgical methods. One of the most important contraindications of PTMC is presence of clot in LAA. So, each patient who suffers of severe MS is evaluated by Trans-Esophageal Echocardiogram to rule out thrombus in LAA before PTMC. At open heart surgery, replacement of the mitral valve was performed for 49-year-old woman. Also, left atrial appendage occlusion was done during surgery. Immediately after surgery, echocardiography demonstrates an echo imitated the presence of a thrombus in left atrial appendage area, although there was not any evidence of thrombus in pre-pump TEE. We can conclude from this case report that when we suspect of thrombus of left atrial, we should obtain exact history of previous surgery of mitral valve to avoid misdiagnosis clotted LAA, instead of obliterated LAA. Consequently, it can prevent additional evaluations and treatments such as oral anticoagulation and exclusion or postponing surgeries including PTMC.

  12. Hypoplastic left heart syndrome

    Directory of Open Access Journals (Sweden)

    Thiagarajan Ravi

    2007-05-01

    Full Text Available Abstract Hypoplastic left heart syndrome(HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis. HLHS has been reported to occur in approximately 0.016 to 0.036% of all live births. Newborn infants with the condition generally are born at full term and initially appear healthy. As the arterial duct closes, the systemic perfusion becomes decreased, resulting in hypoxemia, acidosis, and shock. Usually, no heart murmur, or a non-specific heart murmur, may be detected. The second heart sound is loud and single because of aortic atresia. Often the liver is enlarged secondary to congestive heart failure. The embryologic cause of the disease, as in the case of most congenital cardiac defects, is not fully known. The most useful diagnostic modality is the echocardiogram. The syndrome can be diagnosed by fetal echocardiography between 18 and 22 weeks of gestation. Differential diagnosis includes other left-sided obstructive lesions where the systemic circulation is dependent on ductal flow (critical aortic stenosis, coarctation of the aorta, interrupted aortic arch. Children with the syndrome require surgery as neonates, as they have duct-dependent systemic circulation. Currently, there are two major modalities, primary cardiac transplantation or a series of staged functionally univentricular palliations. The treatment chosen is dependent on the preference of the institution, its experience, and also preference. Although survival following initial surgical intervention has improved significantly over the last 20 years, significant mortality and morbidity are present for both surgical strategies. As a result pediatric cardiologists continue to be challenged by discussions with families regarding initial decision

  13. Idiopathic Stevens-Johnson Syndrome in a Child: a Case Report

    Directory of Open Access Journals (Sweden)

    Amir Hossein Goudarzian

    2016-07-01

    Full Text Available Background Stevens-Johnson syndrome (SJS is one of potentially fatal disorders that often occur after taking certain types of medication. There are reports of this disease after some infections. This paper presents the case of a young boy with idiopathic Stevens-Johnson syndrome. Case Report A six-year-old male patient with complaint of fever and skin lesions was transferred to emergency department of Bu-Ali Sina hospital (Center of Mazandaran province, Iran. After further evaluations (Physical examination and laboratory reports, the patient did not show any common causes of Stevens - Johnson syndrome. Fortunately he was discharged in a good condition after duration of treatment. Conclusion Further studies need to be done in the field of risk factors of Stevens-Johnson syndrome.

  14. Finite Yang-Mills theories and the Bjorken--Johnson--Low limit

    International Nuclear Information System (INIS)

    Ali, A.; Bernstein, J.

    1975-01-01

    We consider the Bjorken-Johnson-Low limit for the propagator in massless Yang-Mills theories. The significance of our result in terms of imposing an eigenvalue on the theory so as to render it finite is discussed

  15. Bilateral conjunctival retention cysts in the aftermath of Stevens-Johnson syndrome

    Directory of Open Access Journals (Sweden)

    Singh Gurdeep

    2008-01-01

    Full Text Available In this case report, we describe the rare occurrence of bilateral conjunctival retention cysts in a child with Stevens-Johnson syndrome. The case was managed conservatively as there were no functional or cosmetic problems.

  16. From Ambiguity to Dogma: The Rhetorical Symbols of Lyndon B. Johnson on Vietnam.

    Science.gov (United States)

    Logue, Cal M.; Patton, John H.

    1982-01-01

    Analyzes President Johnson's casting of political policy into evocative symbols, the invention and operation of those rhetorical forms, the resulting conflict over the symbolization of the Vietnam War, and the theoretical and ethical implications of those rhetorical choices. (PD)

  17. Bronchiolitis obliterans in children with Stevens-Johnson syndrome: follow-up with high resolution CT

    International Nuclear Information System (INIS)

    Kim, M.J.; Lee, K.Y.

    1996-01-01

    About one third of children with Stevens-Johnson syndrome have pulmonary involvement. As a consequence of airway epithelial injury, bronchiolitis obliterans can occur in these patients. Two cases of Stevens-Johnson syndrome-associated bronchiolitis obliterans in children were diagnosed and followed by high resolution CT without open lung biopsy. Serial changes of high resolution CT features of bronchiolitis obliterans are discussed and the literature is reviewed. (orig.)

  18. Steven’s Johnson Syndrome and Toxic Epidermal Necrolysis in Children

    OpenAIRE

    Hakan Turan; Sevgül Vatansever; Özlem Özdemir; Yakup Canıtez; Hayriye Sarıcaoğlu

    2008-01-01

    Aim: The aim of this study was to consider clinical features, laboratory findings, treatment alternatives, complications and responsible agents of Steven’s Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in childhood. Materials and Method: The patients who were diagnosed with Steven’s Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) and followed by Department of Dermatology, Division of Pediatric Neurology and Division of Pediatric Allergy of Uludag University Faculty of...

  19. Steven Johnson syndrome due to I.V Ceftriaxone--a case report.

    OpenAIRE

    Narayanan Veena; Mamatha G; Ashok L; Rajashekar N

    2003-01-01

    Steven-Johnson syndrome (SJS) is a rare vesiculobullous disease characterized by an acute cutaneous eruption that ivolves the skin and mucous membranes including those of the oral cavity. A rare case of Steven-Johnson syndrome, an unexpected treatment response, in a 25-year-old female patient due to administration of intravenous Cefriaxone (1 gm), a third generation cephalosporin has been reported and literature reviewed.

  20. Towards a practical Johnson noise thermometer for long-term measurements in harsh environments

    International Nuclear Information System (INIS)

    Greenen, Adam; Pearce, Jonathan; Cruickshank, David; Bramley, Paul

    2015-01-01

    The impact of mechanical and chemical changes in conventional sensors such as thermocouples and resistance thermometers can be avoided by instead using temperature sensors based on fundamental thermometry. A prime example of this is Johnson noise thermometry, which is based on measurement of the fluctuations in the voltage of a resistor arising from thermal motion of charge carriers - i.e. the 'Johnson noise'. A Johnson noise thermometer never needs calibration and is insensitive to the condition of the sensor material. It is therefore ideally suited to long-term temperature measurements in harsh environments, such as nuclear reactor coolant circuits, in-pile measurements, nuclear waste management and storage, and severe accident monitoring. There have been a number of previous attempts to develop a Johnson noise thermometer for the nuclear industry, but none have reached commercial exploitation because of technical problems in practical implementation. The main challenge is to extract the tiny Johnson noise signal from ambient electrical noise influences, both from the internal amplification electronics, and from external electrical noise sources. Recent advances in electronics technology and digital signal processing techniques have opened up new possibilities for developing a viable, practical Johnson noise thermometer. We describe a project funded by the UK Technology Strategy Board (now Innovate UK) 'Developing the nuclear supply chain' call, currently underway, to develop a practical Johnson noise thermometer that makes use of innovative electronics for ultralow noise amplification and signal processing. The new electronics technology has the potential to help overcome the problems encountered with previous attempts at constructing a practical Johnson noise thermometer. An outline of the new developments is presented, together with an overview of the current status of the project. (authors)

  1. Probabilistic Analysis for Comparing Fatigue Data Based on Johnson-Weibull Parameters

    Science.gov (United States)

    Vlcek, Brian L.; Hendricks, Robert C.; Zaretsky, Erwin V.

    2013-01-01

    Leonard Johnson published a methodology for establishing the confidence that two populations of data are different. Johnson's methodology is dependent on limited combinations of test parameters (Weibull slope, mean life ratio, and degrees of freedom) and a set of complex mathematical equations. In this report, a simplified algebraic equation for confidence numbers is derived based on the original work of Johnson. The confidence numbers calculated with this equation are compared to those obtained graphically by Johnson. Using the ratios of mean life, the resultant values of confidence numbers at the 99 percent level deviate less than 1 percent from those of Johnson. At a 90 percent confidence level, the calculated values differ between +2 and 4 percent. The simplified equation is used to rank the experimental lives of three aluminum alloys (AL 2024, AL 6061, and AL 7075), each tested at three stress levels in rotating beam fatigue, analyzed using the Johnson- Weibull method, and compared to the ASTM Standard (E739 91) method of comparison. The ASTM Standard did not statistically distinguish between AL 6061 and AL 7075. However, it is possible to rank the fatigue lives of different materials with a reasonable degree of statistical certainty based on combined confidence numbers using the Johnson- Weibull analysis. AL 2024 was found to have the longest fatigue life, followed by AL 7075, and then AL 6061. The ASTM Standard and the Johnson-Weibull analysis result in the same stress-life exponent p for each of the three aluminum alloys at the median, or L(sub 50), lives

  2. Incidence, outcomes, and resource use in children with Stevens-Johnson syndrome and toxic epidermal necrolysis.

    Science.gov (United States)

    Antoon, James W; Goldman, Jennifer L; Lee, Brian; Schwartz, Alan

    2018-01-09

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening cutaneous reactions, typically to drugs or infection. The incidence and outcomes of these conditions in children are unknown. The objective of this study was to report the overall burden of Stevens-Johnson syndrome and toxic epidermal necrolysis in children in the United States. We performed a retrospective cohort analysis of children and adolescents younger than 18 years of age using the 2009 and 2012 Kids' Inpatient Database. We identified 1486 children and adolescents hospitalized with a diagnosis of Stevens-Johnson syndrome or toxic epidermal necrolysis. The national incidence per 100 000 was 6.3 for Stevens-Johnson syndrome, 0.7 for Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome, and 0.5 for toxic epidermal necrolysis. The highest incidence in children was in those aged 11-15 years (38.4 per 100 000). Toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome were associated with longer stay, greater mortality, and higher hospital charges than those with Stevens-Johnson syndrome. Hospital mortality was highest in children with toxic epidermal necrolysis and in children aged 0-5 years. The incidence of Stevens-Johnson syndrome and toxic epidermal necrolysis in children is higher than reported in adults, and there are significant age-based variations in incidence and outcomes across the pediatric population. Further study is needed to determine the most effective treatment strategies to reduce costs and improve outcomes in children hospitalized with severe cutaneous reactions. © 2018 Wiley Periodicals, Inc.

  3. MHD peristaltic motion of Johnson-Segalman fluid in a channel with compliant walls

    International Nuclear Information System (INIS)

    Hayat, T.; Javed, Maryiam; Asghar, S.

    2008-01-01

    A mathematical model for magnetohydrodynamic (MHD) flow of a Johnson-Segalman fluid in a channel with compliant walls is analyzed. The flow is engendered due to sinusoidal waves on the channel walls. A series solution is developed for the case in which the amplitude ratio is small. Our computations show that the mean axial velocity of a Johnson-Segalman fluid is smaller than that of a viscous fluid. The variations of various interesting dimensionless parameters are graphed and discussed

  4. Response of itchgrass and johnson grass to asulam/dalapon combinations

    International Nuclear Information System (INIS)

    Hook, B.J.

    1986-01-01

    Activities of asumlam [methyl[(4-aminophenyl)sulfonyl]carbamate], dalapon (2,2-dichloropropionic acid) and asulam/dalapon combinations on itchgrass (Rottboellia exaltata L.f.) and johnson grass [Sorghum halepense (L.) Pers.] were examined. When metabolism of 14 C-asulam was monitored, seven days after application, 97-100% of recovered 14 C co-chromatographed with 14 C-asulam. Itchgrass exhibited rapid uptake of 14 C-asulam within 8 hr after application. Asumlam concentrations remained constant in the plant between 8 and 72 hr. Johnson grass plants showed a differential response to asulam and asulam/dalapon treatments. Asulam-treated johnson grass absorbed 26-34% 14 C within 2 hr with no future significant increase in absorption in absorption through 72 hr. Treatment of johnson grass with asulam/dalapon enhanced 14 C absorption with time. At 24 and 72 hr 14 C levels were double that absorbed from treatment of asulam alone. Movement of 14 C-asulam in the apoplast and symplast of both itchgrass and johnson grass was noted. The highest radiolabel accumulated in the lower leaves of itchgrass and remained in the treated leaf of johnson grass

  5. Unique strategies for technical information management at Johnson Space Center

    Science.gov (United States)

    Krishen, Vijay

    1994-01-01

    In addition to the current NASA manned programs, the maturation of Space Station and the introduction of the Space Exploration programs are anticipated to add substantially to the number and variety of data and documentation at NASA Johnson Space Center (JSC). This growth in the next decade has been estimated at five to ten fold compared to the current numbers. There will be an increased requirement for the tracking and currency of space program data and documents with National pressures to realize economic benefits from the research and technological developments of space programs. From a global perspective the demand for NASA's technical data and documentation is anticipated to increase at local, national, and international levels. The primary users will be government, industry, and academia. In our present national strategy, NASA's research and technology will assume a great role in the revitalization of the economy and gaining international competitiveness. Thus, greater demand will be placed on NASA's data and documentation resources. In this paper the strategies and procedures developed by DDMS, Inc., to accommodate the present and future information utilization needs are presented. The DDMS, Inc., strategies and procedures rely on understanding user requirements, library management issues, and technological applications for acquiring, searching, storing, and retrieving specific information accurately and quickly. The proposed approach responds to changing customer requirements and product deliveries. The unique features of the proposed strategy include: (1) To establish customer driven data and documentation management through an innovative and unique methods to identify needs and requirements. (2) To implement a structured process which responds to user needs, aimed at minimizing costs and maximizing services, resulting in increased productivity. (3) To provide a process of standardization of services and procedures. This standardization is the central

  6. Toxic epidermal necrolysis and Stevens-Johnson syndrome

    Science.gov (United States)

    2010-01-01

    Toxic epidermal necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Currently, TEN and SJS are considered to be two ends of a spectrum of severe epidermolytic adverse cutaneous drug reactions, differing only by their extent of skin detachment. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the aetiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine. Diagnosis relies mainly on clinical signs together with the histological analysis of a skin biopsy showing typical full-thickness epidermal necrolysis due to extensive keratinocyte apoptosis. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP), disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS). Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, evaluation of the prognosis using SCORTEN

  7. Left Ventricular Assist Devices

    Directory of Open Access Journals (Sweden)

    Khuansiri Narajeenron

    2017-04-01

    Full Text Available Audience: The audience for this classic team-based learning (cTBL session is emergency medicine residents, faculty, and students; although this topic is applicable to internal medicine and family medicine residents. Introduction: A left ventricular assist device (LVAD is a mechanical circulatory support device that can be placed in critically-ill patients who have poor left ventricular function. After LVAD implantation, patients have improved quality of life.1 The number of LVAD patients worldwide continues to rise. Left-ventricular assist device patients may present to the emergency department (ED with severe, life-threatening conditions. It is essential that emergency physicians have a good understanding of LVADs and their complications. Objectives: Upon completion of this cTBL module, the learner will be able to: 1 Properly assess LVAD patients’ circulatory status; 2 appropriately resuscitate LVAD patients; 3 identify common LVAD complications; 4 evaluate and appropriately manage patients with LVAD malfunctions. Method: The method for this didactic session is cTBL.

  8. Jimmy Doolittle: Cincinnatus of the Air

    Science.gov (United States)

    2016-07-01

    those] who still think of the Navy as the first line of defense.” 117 During questioning, also Doolittle assaulted the Navy’s two sacred cows —the...signed the National Security Act of 1947 aboard his plane the Sacred Cow before departing to visit his ailing mother. The President also signed...unity of command throughout the acquisition cycle and a single point of contact with industry. The arrangement, however, relegated R&D to a

  9. Jimmy Carter and Playboy: A Sociolinguistic Perspective.

    Science.gov (United States)

    Solomon, Martha

    1978-01-01

    Research by Martin Joos and John J. Gumperz to develop a perspective for rhetorical analysis. Carter's final remarks in his Playboy interview are shown to reflect an ineffective sociolinguistic code shift to a stylistic level inappropriate to Carter as public personality and as presidential candidate. (JF)

  10. Jimmy Doolittle: The Commander behind the Legend

    Science.gov (United States)

    2015-02-01

    described the job as managing a “shotgun wedding between the aviation and automobile industry.”86 The car manufacturers were not interested in building...December 1988, the couple’s 71st wedding anniversary. Doolit- tle and Glines, I Could Never Be So Lucky Again, 37–38. 9. Doolittle, interview by...final decision is made you will feel able to leave Eaker here.”5 Similarly, during Doolittle’s ceremonial meeting with King George VI on 4 February

  11. Left Ventricular Pseudoaneurysm Perceived as a Left Lung Mass

    Directory of Open Access Journals (Sweden)

    Ugur Gocen

    2013-02-01

    Full Text Available Left ventricular pseudo-aneurysm is a rare complication of aneurysmectomy. We present a case of surgically-treated left ventricular pseudo-aneurysm which was diagnosed three years after coronary artery bypass grafting and left ventricular aneurysmectomy. The presenting symptoms, diagnostic evaluation and surgical repair are described. [Cukurova Med J 2013; 38(1.000: 123-125

  12. Johnson Creek Artificial Propagation and Enhancement Project Operations and Maintenance Program; Brood Year 2000: Johnson Creek Chinook Salmon Supplementation, Biennial Report 2000-2002.

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, Mitch; Gebhards, John; Hill, Robert

    2003-05-01

    The Nez Perce Tribe, through funding provided by the Bonneville Power Administration, has implemented a small scale chinook salmon supplementation program on Johnson Creek, a tributary in the South Fork of the Salmon River, Idaho. The Johnson Creek Artificial Propagation Enhancement project was established to enhance the number of threatened Snake River summer chinook salmon (Oncorhynchus tshawytscha) returning to Johnson Creek through artificial propagation. Adult chinook salmon trapping, broodstock selection, and spawning was first implemented in 1998, did not occur in 1999, and was resumed in 2000. A total of 152 salmon were trapped in Johnson Creek in 2000, of which 73 (25 males, 16 females, and 32 jacks) fish were transported to Idaho Fish and Game=s South Fork Salmon River adult holding and spawning facility for artificial propagation purposes. The remaining 79 (29 males, 16 females, and 24 jacks) fish were released above the weir to spawn naturally. A total of 65,060 green eggs were taken from 16 female salmon and transported to the McCall Fish Hatchery for incubation and rearing. Egg counts indicated an average eye-up rate of 86.0% for 55,971 eyed eggs. Average fecundity for Johnson Creek females was 4,066 eggs per female. Juvenile fish were reared indoors at the McCall Fish Hatchery through November 2001. These fish were transferred to outdoor rearing facilities in December 2001 where they remained until release in March 2002. All of these fish were marked with Coded Wire Tags and Visual Implant Elastomer tags. In addition 9,987 were also PIT tagged. Hand counts provided by marking crews were used to amend the number of juvenile salmon released from the original egg count. A total of 57,392 smolts were released into a temporary acclimation channel in Johnson Creek on March 18, 19, 20, 2002. These fish were held in this facility until a fish screen was removed on March 22, 2002 and the fish were allowed to emigrate.

  13. [Fatal toxic respiratory epitheliolysis. Subacute tracheo-bronchial desquamation in Stevens-Johnson syndrome].

    Science.gov (United States)

    Martin, L; Hazouard, E; Michalak-Provost, S; Maurage, C; Machet, L

    2001-09-01

    Acute bronchial mucosal sloughing related to Toxic Epidermal Necrolysis (Lyell syndrome) is widely reported in literature. On the contrary severe respiratory involvement is rare in post-infectious or toxic Epitheliolysis (Stevens-Johnson syndrome). There is no well-known predictive sign of bronchial epithelium involvement. An 18-year-old patient was admitted for Stevens-Johnson syndrome related to sulfasalazine (salazosulfapyridine). There were no respiratory signs. An acute respiratory failure occurred 36 hours after from admission due to an obstructive and desquamative necrosis of the tracheobronchial epithelium. We purpose that a fiberoptic laryngoscopy should be performed even in non-dyspneic patients suffering from Stevens-Johnson syndrome if hypersecretion is present. Fiberoptic bronchoscopy can be helpful in these cases.

  14. Stevens-Johnson Syndrome triggered by chemical hair relaxer: a case report

    Science.gov (United States)

    Booker, Matthew J

    2009-01-01

    This case report describes a 41-year-old Afro-Caribbean lady presenting with a constellation of pyrexia, conjunctivitis, arthralgia, sterile dysuria, apthous ulceration, labial crusting and widespread erythema multiforme. A diagnosis of Stevens-Johnson Syndrome was made. She had taken no medications recently (the most common precipitant of Stevens-Johnson Syndrome) and a full screen for the common and atypical bacterial and viral triggers was negative. The identified trigger was the use of a chemical hair relaxant treatment a few days previously. With supportive measures and a course of oral prednisolone, the patient quickly improved and made a full recovery. This case highlights the importance of considering occupational and recreational precipitants of Stevens-Johnson Syndrome. PMID:19918477

  15. Bronchiolitis obliterans associated with Stevens-Johnson syndrome: a case report.

    Science.gov (United States)

    Park, Hyungchul; Ko, Young Bo; Kwon, Hyouk-Soo; Lim, Chae-Man

    2015-03-01

    We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous airway disease. On physical examination, expiratory breathing sounds were not audible, and a chest X-ray revealed a hyperinflated lung. A pulmonary function test indicated a severe obstructive pattern. Computed tomography scans of inspiratory and expiratory phases of respiration showed oligemia and air trapping, and both were more prominent on expiration view than on inspiration view. The pathogenesis of bronchiolitis obliterans associated with Stevens-Johnson syndrome is largely unknown.

  16. Diagnosis and management of drug-induced stevens-johnson syndrome: Report of two cases

    Directory of Open Access Journals (Sweden)

    M Venkateshwarlu

    2011-01-01

    Full Text Available Erythema multiforme (EM is a typically mild, self-limiting and recurring mucocutaneous reaction characterized by target or iris lesions of the skin and mucous membranes. It is most often a recurring phenomenon with great variability in the interval between episodes. It is much more common in persons under 40 years of age. In contrast, Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are less common and more severe conditions that typically occur in adults. SJS and TEN are severe variants of EM usually caused by a drug exposure. We report two cases of Stevens-Johnsons syndrome following drug intake. There is an increased incidence of SJS and TEN in the HIV-infected population. 1 Herewith, we report two cases of Stevens-Johnson syndrome in one patient following drug intake and other in a HIV-infected patient.

  17. Why Dora Left

    DEFF Research Database (Denmark)

    Gammelgård, Judy

    2017-01-01

    The question of why Dora left her treatment before it was brought to a satisfactory end and the equally important question of why Freud chose to publish this problematic and fragmentary story have both been dealt with at great length by Freud’s successors. Dora has been read by analysts, literary...... critics, and not least by feminists. The aim of this paper is to point out the position Freud took toward his patient. Dora stands out as the one case among Freud’s 5 great case stories that has a female protagonist, and reading the case it becomes clear that Freud stumbled because of an unresolved...... problem toward femininity, both Dora’s and his own. In Dora, it is argued, Freud took a new stance toward the object of his investigation, speaking from the position of the master. Freud presents himself as the one who knows, in great contrast to the position he takes when unraveling the dream. Here he...

  18. Defining, navigating, and negotiating success: the experiences of mid-career Robert Wood Johnson Clinical Scholar women.

    Science.gov (United States)

    Kalet, Adina L; Fletcher, Kathlyn E; Ferdman, Dina J; Bickell, Nina A

    2006-09-01

    We studied female graduates of the Robert Wood Johnson Clinical Scholars Program (CSP, Class of 1984 to 1989) to explore and describe the complexity of creating balance in the life of mid-career academic woman physicians. We conducted and qualitatively analyzed (kappa 0.35 to 1.0 for theme identification among rater pairs) data from a semi-structured survey of 21 women and obtained their curricula vitae to quantify publications and grant support, measures of academic productivity. Sixteen of 21 (76%) women completed the survey. Mean age was 48 (range: 45 to 56). Three were full professors, 10 were associate professors, and 3 had left academic medicine. Eleven women had had children (mean 2.4; range: 1 to 3) and 3 worked part-time. From these data, the conceptual model expands on 3 key themes: (1) defining, navigating, and negotiating success, (2) making life work, and (3) making work work. The women who described themselves as satisfied with their careers (10/16) had clarity of values and goals and a sense of control over their time. Those less satisfied with their careers (6/16) emphasized the personal and professional costs of the struggle to balance their lives and described explicit institutional barriers to fulfillment of their potential. For this group of fellowship-prepared academic women physicians satisfaction is achieving professional and personal balance.

  19. Dual-mode self-validating resistance/Johnson noise thermometer system

    Science.gov (United States)

    Shepard, Robert L.; Blalock, Theron V.; Roberts, Michael J.

    1993-01-01

    A dual-mode Johnson noise and DC resistance thermometer capable of use in control systems where prompt indications of temperature changes and long term accuracy are needed. A resistance-inductance-capacitance (RLC) tuned circuit produces a continuous voltage signal for Johnson noise temperature measurement. The RLC circuit provides a mean-squared noise voltage that depends only on the capacitance used and the temperature of the sensor. The sensor has four leads for simultaneous coupling to a noise signal processor and to a DC resistance signal processor.

  20. Danish resonances and repercussions in the life and work of William H. Johnson

    DEFF Research Database (Denmark)

    Sørensen, Bent

    William H. Johnson was an outstanding African-American artist, represented with hundreds of works in the Smithsonian Museum of American Art’s collection, but he was also a resident of Denmark for the better part of the 1930s, and again for a brief spell after WWII. While studying art in Paris...... and the rest of Scandinavia in that period. I shall take a look at the reception of his work (and that of Holcha Krake) in all three Scandinavian countries (they both spent considerable time in Norway and Sweden as well as in Holcha’s native Denmark) which routinely exoticizes Johnson and his art in language...

  1. Using Johnson Distribution for Automatic Threshold Setting in Wind Turbine Condition Monitoring System

    DEFF Research Database (Denmark)

    Marhadi, Kun Saptohartyadi; Skrimpas, Georgios Alexandros

    2014-01-01

    not rep- resent the whole operating conditions of a turbine, which re- sults in uncertainty in the parameters of the fitted probabil- ity distribution and the thresholds calculated. In this study Johnson distribution is used to identify shape, location, and scale parameters of distribution that can best...... fit vibration data. This study shows that using Johnson distribution can elim- inate testing or fitting various distributions to the data, and have more direct approach to obtain optimal thresholds. To quantify uncertainty in the thresholds due to limited data, im- plementations with bootstrap method...

  2. Stevens-Johnson Syndrome: A Review and Report of Two Cases.

    Science.gov (United States)

    Gandhi, Roopa P; Klein, Ulrich

    2017-01-15

    Stevens-Johnson syndrome (SJS) is a rare condition, characterized by its dramatic involvement of the skin and various mucosal surfaces including the oral mucosae, that severely impairs the affected patient's ability to speak, chew, or swallow. The purpose of this report was to present two cases with significant variations in the clinical presentation of Stevens-Johnson syndrome. In both situations, the patients' conditions were not immediately recognized. Pediatric dentists should be aware of these variations in the clinical manifestations of SJS, as the signs and symptoms can initially mimic common viral conditions. Appropriate diagnosis can result in timely referral to a hospital environment, optimizing patient management and recovery.

  3. Report of the EMI Testing of the Johnson Noise Thermometry System

    Energy Technology Data Exchange (ETDEWEB)

    Britton Jr., Charles L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Roberts, Michael [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-06-01

    This report summarizes the Electromagnetic Interference (EMI) testing of the Johnson Noise Thermometry System developed at ORNL. The EMI performance is very important for Johnson Noise Thermometry because it requires accurate measurement of a very small noise signal that is amplified 10,000 times. Any interference in the form on pickup from external signal sources from such as fluorescent lighting ballasts, motors, etc. can skew the measurement. Testing is therefore very important in determining the effects of these external noise sources. Results from testing in several environments with various sources of EMI are presented here.

  4. Non-compact left ventricle/hypertrabeculated left ventricle

    International Nuclear Information System (INIS)

    Restrepo, Gustavo; Castano, Rafael; Marmol, Alejandro

    2005-01-01

    Non-compact left ventricle/hypertrabeculated left ventricle is a myocardiopatie produced by an arrest of the normal left ventricular compaction process during the early embryogenesis. It is associated to cardiac anomalies (congenital cardiopaties) as well as to extracardial conditions (neurological, facial, hematologic, cutaneous, skeletal and endocrinological anomalies). This entity is frequently unnoticed, being diagnosed only in centers with great experience in the diagnosis and treatment of myocardiopathies. Many cases of non-compact left ventricle have been initially misdiagnosed as hypertrophic myocardiopatie, endocardial fibroelastosis, dilated cardiomyopatie, restrictive cardiomyopathy and endocardial fibrosis. It is reported the case of a 74 years old man with a history of chronic arterial hypertension and diabetes mellitus, prechordial chest pain and mild dyspnoea. An echocardiogram showed signs of non-compact left ventricle with prominent trabeculations and deep inter-trabecular recesses involving left ventricular apical segment and extending to the lateral and inferior walls. Literature on this topic is reviewed

  5. Mechanical discordance between left atrium and left atrial appendage

    Directory of Open Access Journals (Sweden)

    Arash Khamooshian

    2018-01-01

    Full Text Available During standard transesophageal echocardiographic examinations in sinus rhythm (SR patients, the left atrial appendage (LAA is not routinely assessed with Doppler. Despite having a SR, it is still possible to have irregular activity in the LAA. This situation is even more important for SR patients where assessment of the left atrium is often foregone. We describe a case where we encountered this situation and briefly review how to assess the left atrium and its appendage in such a case scenario.

  6. [Left-handedness and health].

    Science.gov (United States)

    Milenković, Sanja; Belojević, Goran; Kocijancić, Radojka

    2010-01-01

    Hand dominance is defined as a proneness to use one hand rather than another in performing the majority of activities and this is the most obvious example of cerebral lateralization and an exclusive human characteristic. Left-handed people comprise 6-14% of the total population, while in Serbia, this percentage is 5-10%, moving from undeveloped to developed environments, where a socio-cultural pressure is less present. There is no agreement between investigators who in fact may be considered a left-handed person, about the percentage of left-handers in the population and about the etiology of left-handedness. In the scientific literature left-handedness has been related to health disorders (spine deformities, immunological disorders, migraine, neurosis, depressive psychosis, schizophrenia, insomnia, homosexuality, diabetes mellitus, arterial hypertension, sleep apnea, enuresis nocturna and Down Syndrome), developmental disorders (autism, dislexia and sttutering) and traumatism. The most reliable scientific evidences have been published about the relationship between left-handedness and spinal deformities in school children in puberty and with traumatism in general population. The controversy of other results in up-to-now investigations of health aspects of left-handedness may partly be explained by a scientific disagreement whether writing with the left hand is a sufficient criterium for left-handedness, or is it necessary to investigate other parameters for laterality assessment. Explanation of health aspects of left-handedness is dominantly based on Geschwind-Galaburda model about "anomalous" cerebral domination, as a consequence of hormonal disbalance.

  7. Drug‑induced Stevens–Johnson Syndrome in Indian Population: A ...

    African Journals Online (AJOL)

    2017-09-14

    Sep 14, 2017 ... Drug-induced Stevens–Johnson syndrome in Indian population: A multicentric retrospective analysis. Niger J Clin Pract 2017;20:978-83. This is an open access article distributed under the terms of the Creative Commons. Attribution-Non Commercial-Share Alike 3.0 License, which allows others to remix,.

  8. Testing a Threshold: An Approximate Replication of Johnson, Mercado & Acevedo 2012

    Science.gov (United States)

    Johnson, Mark D.; Nicodemus, Christine L.

    2016-01-01

    In order to better understand the role of working memory in second language (L2) written production, this study contributes to recent research attempting to apply Kellogg's model of working memory in first language (L1) writing to L2 writing research (Ellis & Yuan 2004; Ong & Zhang 2010; Johnson, Mercado & Acevedo 2012). This paper…

  9. Testing the Construct Validity of Dixon and Johnson's (2007) Gambling Functional Assessment

    Science.gov (United States)

    Miller, Joseph C.; Meier, Ellen; Muehlenkamp, Jennifer; Weatherly, Jeffrey N.

    2009-01-01

    The Gambling Functional Assessment (GFA; Dixon & Johnson, 2007) is a 20-item self-report inventory identifying four potential consequences maintaining gambling behavior. Exploratory and confirmatory factor analyses are performed for two large, nonclinical samples of university undergraduates. For the exploratory analysis, the optimal model…

  10. 50 CFR 80.25 - Multiyear financing under the Dingell-Johnson Sport Fish Restoration Program.

    Science.gov (United States)

    2010-10-01

    ... Program. (a) States may finance the acquisition of lands or interests in lands including water rights and...-Johnson Sport Fish Restoration Act in two ways: (1) States may finance the entire cost of the acquisition or construction from a non-Federal funding source and claim Federal reimbursement in succeeding...

  11. Does Johnson's Prescriptive Approach Still Have a Role to Play in ...

    African Journals Online (AJOL)

    Samuel Johnson's dictionary (1755) confirmed both the status of dictionaries as authoritative sources of (linguistic) knowledge and the prescriptive approach in lexicography. This approach prevailed for a long time. During the last decades the descriptive approach came to the fore, aptly supported by the increased reliance ...

  12. Taxonomic revision of the afrotropical genus Megatrigon Johnson, 1898 (Diptera: Syrphidae)

    DEFF Research Database (Denmark)

    Doczkal, Dieter; Radenković, Snežana; Lyneborg, Leif

    2016-01-01

    The genus-group taxon Megatrigon Johnson, 1898, stat. nov., is revised and treated as a valid genus within the Merodontini (= Eumerini). Extensive diagnoses are given for the genus and for its three constituent species groups: argenteus group [11 spp.], nivalis group [monotypic], sexfasciatus group...

  13. Income and Democracy: A Comment on Acemoglu, Johnson, Robinson, and Yared (2008)

    DEFF Research Database (Denmark)

    Paldam, Martin; Gundlach, Erich

    Acemoglu, Johnson, Robinson, and Yared (2008) demonstrate that estimation of the standard adjustment model with country-fixed and time-fixed effects removes the statistical significance of income as a causal factor of democracy. We argue that their empirical approach must produce insignificant...

  14. Yang--Mills gauge theories and Baker--Johnson quantum electrodynamics

    International Nuclear Information System (INIS)

    Lemmon, J.; Mahanthappa, K.T.

    1976-01-01

    We show that the physical mass of a fermion in a symmetric asymptotically free non-Abelian vector gauge theory is dynamical in origin. We comment on the close analogy that exists between such a theory and the Baker--Johnson finite quantum electrodynamics. Comments are also made when there is spontaneous symmetry breaking

  15. Regional Super ESPC Saves Energy and Dollars at NASA's Johnson Space Center

    International Nuclear Information System (INIS)

    Federal Energy Management Program

    2001-01-01

    This case study about energy saving performance contacts (ESPCs) presents an overview of how the NASA's Johnson Space Flight Center established an ESPC contract and the benefits derived from it. The Federal Energy Management Program instituted these special contracts to help federal agencies finance energy-saving projects at their facilities

  16. Evaluation of the Johnson AG-1007-7 (G-7) microwave motion detection system

    International Nuclear Information System (INIS)

    1979-01-01

    A series of tests was performed on the Johnson Model AG-1007-7 motion detection system. The primary objectives of these tests were to determine sensor detection patterns and to quantitate the effects of intruder velocity. System susceptibility to fluorescent lights, oscillatory motion, and environmental factors was also examined

  17. Employment, Salary & Placement Information for Johnson County Community College Career Programs.

    Science.gov (United States)

    Conklin, Karen A.

    More than forty-six career programs are offered at Johnson County Community College (JCCC) in Kansas, in such areas as Cosmetology, Dental Assistance, and Travel and Tourism. These programs specialize in the types of industries that are currently growing at high rates, such as computer-related occupations and special education teachers. This…

  18. Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case.

    Science.gov (United States)

    Avinash, A; Amberkar, V Mohanbabu; Kunder, Sushil Kiran; Madhyastha, Sharath; Meenakumari, K

    2016-12-01

    Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal. The co-existence of Stevens-Johnson syndrome and agranulocytosis in the same patient further increases the risk of morbidity and mortality. To the best of our knowledge, there are no reports available in the existing literature, of cases that were reported with both these life-threatening conditions in a single patient, at the same point of time. This is a case narrative of a patient who presented with both Stevens-Johnson syndrome and agranulocytosis, following the administration of carbamazepine The patient's differential leucocyte count revealed a neutrophil proportion of 2.33%. A causality assessment done using Naranjo's algorithm showed that carbamazepine "definitely" caused Agranulocytosis and "probably" caused Stevens-Johnson syndrome.

  19. Stevens-Johnson syndrome progressing to toxic epidermal necrolysis with haloperidol and carbamazepine combination

    Directory of Open Access Journals (Sweden)

    Ajay Kumar

    2011-01-01

    Full Text Available Carbamazepine and other anticonvulsants are commoner cause of severe adverse cutaneous drug reactions such as erythema multiforme, toxic epidermal necrolysis (TEN, and Stevens-Johnson syndrome (SJS. We report a case of SJS rapidly progressing to TEN with a combination of haloperidol and carbamazepine in a patient with bipolar affective disorder. The pathophysiological mechanism underlying this reaction is discussed.

  20. Conjunctival inflammation in the chronic phase of Stevens-Johnson syndrome

    Science.gov (United States)

    Kawasaki, S.; Nishida, K.; Sotozono, C.; Quantock, A.; Kinoshita, S.

    2000-01-01

    AIMS—To understand the immunopathogenesis of the corneal conjunctivalisation in Stevens-Johnson syndrome.
METHODS—Conjunctivalised corneas from five patients with Stevens-Johnson syndrome were studied immunohistochemically for several cell surface antigens and two cytokines. Chemical injury specimens were also studied.
RESULTS—In all cases, immunohistochemistry revealed LFA-1, CD4, CD8, and CD68 on subepithelial infiltrating cells. Also, HLA-DR and ICAM-1 were found on the surfaces of epithelial cells, subepithelial infiltrating cells, subepithelial fibroblasts, and endothelial cells in blood vessels. IFN-γ was found in basal epithelial cells; subepithelial cells and subepithelial extracellular matrix CD19 and IL4 were not detected.
CONCLUSIONS—The infiltrating cell population in the Stevens-Johnson syndrome samples includes macrophages, CD4 positive T cells, and CD8 positive T cells. The cytokine expression pattern suggests CD4 positive T cells are Th1 cells. The infiltrating cell population is similar in Stevens-Johnson syndrome and chemical injury conjunctivalised corneas.

 PMID:11004109

  1. Dexamethasone pulse therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis

    NARCIS (Netherlands)

    Kardaun, Sylvia H.; Jonkman, Marcel F.

    2007-01-01

    Mortality in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is high. Apart from intensive supportive therapy, no generally accepted specific treatment regimen exists. The role of corticosteroids in SJS/TEN is controversial. It is possible that high-dose pulse therapy with

  2. Comprehensive Survival Analysis of a Cohort of Patients with Stevens Johnson Syndrome and Toxic Epidermal Necrolysis

    NARCIS (Netherlands)

    Sekula, Peggy; Dunant, Ariane; Mockenhaupt, Maja; Naldi, Luigi; Bavinck, Jan Nico Bouwes; Halevy, Sima; Kardaun, Sylvia; Sidoroff, Alexis; Liss, Yvonne; Schumacher, Martin; Roujeau, Jean-Claude

    Stevens Johnson syndrome and toxic epidermal necrolysis are severe cutaneous adverse reactions that are of major concern because of high mortality rates. On the basis of data collected in the RegiSCAR study, the aim was to assess risk factors (including modalities of patient management) for

  3. 78 FR 29367 - Access to Confidential Business Information by ABT Associates, Incorporated; Perry Johnson...

    Science.gov (United States)

    2013-05-20

    ... contractor ABT Associates, Incorporated (ABT) and six (6) auditing organizations: Perry Johnson Registrars...), Resource Conservation and Sustainability Division (RCSD) as it conducts a study of the implementation of... industry to contain auditing tools, ownership/operation agreements, amounts and types of e-waste processed...

  4. Obituary Betty Johnson - tireless advocate for woment to pursue - and return to - scientific careers

    CERN Multimedia

    Perry, K

    2003-01-01

    "The physicist Professor Elizabeth (Betty) Johnson, who has died aged 66, was a major force in the establishment of the Daphne Jackson Trust in 1992 to help women returning to science after a career break. She worked tirelessly to encourage women into science, both through her own example as a female scientist and her advocacy of science as a career" (1/2 page).

  5. Achievement of Elementary School Students and Attendance in Preschool Programs in Johnson County, Tennessee

    Science.gov (United States)

    South, Emogene

    2014-01-01

    The purpose of this study was to determine if a difference in achievement scores exist between students who attended the Johnson County School System preschool program and those who did not as measured by standardized TCAP achievement test Reading/Language Arts and Math scores of students in the third and fourth grades. The variables of grade…

  6. Johnson Creek Landslide research project, Lincoln County, Oregon : final report to the Oregon Department of Transportation.

    Science.gov (United States)

    2008-07-01

    A five-year study indicates that the Johnson Creek landslide moves in response to intense rainfall that raises pore water : pressure throughout the slide in the form of pulses of water pressure traveling from the headwall graben down the axis of : th...

  7. Fighting with Reality: Considering Mark Johnson's Pragmatic Realism through Bruce Lee's Jeet Kune Do Method

    Science.gov (United States)

    Miller, Alexander David

    2015-01-01

    This dissertation considers the supportive and complementary relation between Mark Johnson's embodied realism and Bruce Lee's Jeet Kune Do as a philosophical practice. In exploring this relationship, the emphasis on one's embodiment condition and its relationship with metaphor and self-expression are the primary focus. First, this work involves…

  8. Stevens-Johnson syndrome in a patient with rheumatoid arthritis during long-term etanercept therapy.

    Science.gov (United States)

    Owczarczyk-Saczonek, Agnieszka; Zdanowska, Natalia; Znajewska-Pander, Aleksandra; Placek, Waldemar

    2016-03-31

    Etanercept and other anti-TNF-alpha agents have been indicated as a therapeutic option in severe drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Etanercept has been shown to quickly reduce the detachment of the epidermis and shorten healing time. Cases of etanercept-induced severe adverse drug reactions were also described. A 27-year-old woman with a 4-year history of etanercept and sulfasalazine treatment for rheumatoid arthritis was admitted with Stevens-Johnson syndrome. The patient received one dose of an OTC drug containing acetaminophen, phenylephrine and pheniramine two days prior to developing fist mucocutaneous symptoms. The most probable causative agent was paracetamol. Throughout the successful routine therapy of Stevens-Johnson syndrome etanercept therapy was continued. Sulfosalazin administration was stopped and administered again after recovery with no recurrence of the skin and mucosal symptoms. This case indicates that there is no justification for discontinuation of long-term anti-TNF-alpha treatment in patients who develop Stevens- Johnson syndrome / toxic epidermal necrolysis.

  9. 78 FR 34428 - Missouri Central Railroad Company-Abandonment Exemption-in Cass, Henry, Johnson, and Pettis...

    Science.gov (United States)

    2013-06-07

    ... No. AB 1070; (Sub-No. 1X)] Missouri Central Railroad Company--Abandonment Exemption--in Cass, Henry, Johnson, and Pettis Counties, MO; Central Midland Railway Company--Discontinuance of Service Exemption--in Cass, Henry, Johnson, and Pettis Counties, MO Missouri Central Railroad Company (MCRR) and Central...

  10. 77 FR 63873 - Johnson Controls, Inc. Including On-Site Leased Workers of Valley Staffing and AZ Quality Hudson...

    Science.gov (United States)

    2012-10-17

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,067] Johnson Controls, Inc... workers of Johnson Controls, Inc., including on-site leased workers from Valley Staffing, Hudson... subject firm. The company reports that workers leased from AZ Quality were employed on-site at the Hudson...

  11. Interleukin-15 Is Associated with Severity and Mortality in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

    NARCIS (Netherlands)

    Su, Shih-Chi; Mockenhaupt, Maja; Wolkenstein, Pierre; Dunant, Ariane; Le Gouvello, Sabine; Chen, Chun-Bing; Chosidow, Olivier; Valeyrie-Allanore, Laurence; Bellon, Teresa; Sekula, Peggy; Wang, Chuang-Wei; Schumacher, Martin; Kardaun, Sylvia H.; Hung, Shuen-Iu; Roujeau, Jean-Claude; Chung, Wen-Hung

    Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome/toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in StevensJohnson syndrome/TEN. Through screening a panel of 28 serological factors, IL-6,

  12. Effective Evaluation of the FRIENDS Anxiety Prevention Program in School Settings: A Response to Maggin and Johnson

    Science.gov (United States)

    Barrett, Paula M.; Cooper, Marita; Stallard, Paul; Zeggio, Larissa; Gallegos- Guajardo, Julia

    2017-01-01

    This response aims to critically evaluate the methodology and aims of the meta-analytic review written by Maggin and Johnson (2014). The present authors systematically provide responses for each of the original criticisms and highlight concerns regarding Maggin and Johnson's methodology, while objectively describing the current state of evidence…

  13. Early-stage evolution of particle size distribution with Johnson's SB function due to Brownian coagulation

    International Nuclear Information System (INIS)

    Tang Hong; Lin Jianzhong

    2013-01-01

    The moment method can be used to determine the time evolution of particle size distribution due to Brownian coagulation based on the general dynamic equation (GDE). But the function form of the initial particle size distribution must be determined beforehand for the moment method. If the assumed function type of the initial particle size distribution has an obvious deviation from the true particle population, the evolution of particle size distribution may be different from the real evolution tendency. Thus, a simple and general method is proposed based on the moment method. In this method, the Johnson's S B function is chosen as a general distribution function to fit the initial distributions including the log normal (L-N), Rosin–Rammler (R-R), normal (N-N) and gamma distribution functions, respectively. Meanwhile, using the modified beta function to fit the L-N, R-R, N-N and gamma functions is also conducted as a comparison in order to present the advantage of the Johnson's S B function as the general distribution function. And then, the time evolution of particle size distributions using the Johnson's S B function as the initial distribution can be obtained by several lower order moment equations of the Johnson's S B function in conjunction with the GDE during the Brownian coagulation process. Simulation experiments indicate that fairly reasonable results of the time evolution of particle size distribution can be obtained with this proposed method in the free molecule regime, transition regime and continuum plus near continuum regime, respectively, at the early time stage of evolution. The Johnson's S B function has the ability of describing the early time evolution of different initial particle size distributions. (paper)

  14. Stevens-Johnson syndrome and toxic epidermal necrolysis at the University Hospital of the West Indies, Jamaica.

    Science.gov (United States)

    East-Innis, A D; Thompson, D S

    2013-09-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are uncommon acute dermatologic disorders. The purpose of this study was to examine the frequency, aetiology and outcome of cases of Stevens-Johnson syndrome and toxic epidermal necrolysis admitted to the dermatology ward at the University Hospital of the West Indies. This was a retrospective study looking at all patients who were admitted with a diagnosis of Stevens-Johnson syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome and toxic epidermal necrolysis over a nine-year period. The results showed almost equal numbers of males and females. The drugs most commonly implicated were phenytoin and cotrimoxazole. The most common complications were hepatic impairment and ophthalmic complications. Stevens-Johnson syndrome and toxic epidermal necrolysis contribute significantly to morbidity and mortality of patients on the dermatology ward although mortality was low compared to other studies.

  15. Myxoma of the Left Ventricle

    Science.gov (United States)

    Novoa, José; Delgado, Antonio; Alonso, Ana

    2014-01-01

    This report concerns a 69-year-old woman who presented with an asymptomatic myxoma in the left ventricle. The tumor was successfully excised. We provide a very brief review of 72 other published cases of surgically treated left ventricular myxoma. PMID:25120392

  16. Left ventricular hypertrophy in athletes.

    Science.gov (United States)

    Douglas, P S; O'Toole, M L; Katz, S E; Ginsburg, G S; Hiller, W D; Laird, R H

    1997-11-15

    Left ventricular wall thickness >1.3 cm, septal-to-posterior wall ratios > 1.5, diastolic left ventricular size >6.0 cm, and eccentric or concentric remodeling are rare in athletes. Values outside of these cutoffs in an athlete of any age probably represent a pathologic state.

  17. The Left-Handed Writer.

    Science.gov (United States)

    Bloodsworth, James Gaston

    Contrary to the beliefs of many, right-handedness is not a single factor existing in almost all people, with a few exceptions termed left-handed: neither extreme exists independently of the other. During the first 4 years of life there is a period of fluctuation between right and left-handed dominance. Statistics and findings vary in determining…

  18. Two Lefts in Latin America?

    DEFF Research Database (Denmark)

    Christensen, Steen Fryba

    In this working paper I list five researchers' categorizations of the Latin American left in power (april 2006) in a schematic form. The most important criteria for the categorizations are given.......In this working paper I list five researchers' categorizations of the Latin American left in power (april 2006) in a schematic form. The most important criteria for the categorizations are given....

  19. A Giant Left Atrial Myxoma

    Directory of Open Access Journals (Sweden)

    Medhat F. Zaher

    2014-01-01

    Full Text Available Atrial myxomas are the most common primary cardiac tumors. Patients with left atrial myxomas generally present with mechanical obstruction of blood flow, systemic embolization, and constitutional symptoms. We present a case of an unusually large left atrial myxoma discovered incidentally in a patient with longstanding dyspnea being managed as bronchial asthma.

  20. Left-handedness and health

    Directory of Open Access Journals (Sweden)

    Milenković Sanja

    2010-01-01

    Full Text Available Hand dominance is defined as a proneness to use one hand rather than another in performing the majority of activities and this is the most obvious example of cerebral lateralization and an exclusive human characteristic. Left-handed people comprise 6-14% of the total population, while in Serbia, this percentage is 5-10%, moving from undeveloped to developed environments, where a socio-cultural pressure is less present. There is no agreement between investigators who in fact may be considered a left-handed person, about the percentage of left-handers in the population and about the etiology of left-handedness. In the scientific literature left-handedness has been related to health disorders (spine deformities, immunological disorders, migraine, neurosis, depressive psychosis, schizophrenia, insomnia, homosexuality, diabetes mellitus, arterial hypertension, sleep apnea, enuresis nocturna and Down Syndrome, developmental disorders (autism, dislexia and sttutering and traumatism. The most reliable scientific evidences have been published about the relationship between left-handedness and spinal deformities in school children in puberty and with traumatism in general population. The controversy of other results in up-to-now investigations of health aspects of left-handedness may partly be explained by a scientific disagreement whether writing with the left hand is a sufficient criterium for left-handedness, or is it necessary to investigate other parameters for laterality assessment. Explanation of health aspects of left-handedness is dominantly based on Geschwind-Galaburda model about 'anomalous' cerebral domination, as a consequence of hormonal disbalance. .

  1. Left ventricular wall stress compendium.

    Science.gov (United States)

    Zhong, L; Ghista, D N; Tan, R S

    2012-01-01

    Left ventricular (LV) wall stress has intrigued scientists and cardiologists since the time of Lame and Laplace in 1800s. The left ventricle is an intriguing organ structure, whose intrinsic design enables it to fill and contract. The development of wall stress is intriguing to cardiologists and biomedical engineers. The role of left ventricle wall stress in cardiac perfusion and pumping as well as in cardiac pathophysiology is a relatively unexplored phenomenon. But even for us to assess this role, we first need accurate determination of in vivo wall stress. However, at this point, 150 years after Lame estimated left ventricle wall stress using the elasticity theory, we are still in the exploratory stage of (i) developing left ventricle models that properly represent left ventricle anatomy and physiology and (ii) obtaining data on left ventricle dynamics. In this paper, we are responding to the need for a comprehensive survey of left ventricle wall stress models, their mechanics, stress computation and results. We have provided herein a compendium of major type of wall stress models: thin-wall models based on the Laplace law, thick-wall shell models, elasticity theory model, thick-wall large deformation models and finite element models. We have compared the mean stress values of these models as well as the variation of stress across the wall. All of the thin-wall and thick-wall shell models are based on idealised ellipsoidal and spherical geometries. However, the elasticity model's shape can vary through the cycle, to simulate the more ellipsoidal shape of the left ventricle in the systolic phase. The finite element models have more representative geometries, but are generally based on animal data, which limits their medical relevance. This paper can enable readers to obtain a comprehensive perspective of left ventricle wall stress models, of how to employ them to determine wall stresses, and be cognizant of the assumptions involved in the use of specific models.

  2. Investigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome

    Directory of Open Access Journals (Sweden)

    Sevil Toka

    2012-09-01

    Full Text Available Objective: Monnose-Binding lectin (MBL appears to play an important role in the immune system. The genetic polymorphisms in the MBL2 gene can result in a reduction of serum levels, leading to a predisposition to recurrent infection. The aim of this study is to investigate the influence of a polymorphism in codon 54 of the MBL2 gene on the susceptibility to Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome (EM, SJS and SJS/TEN overlap syndrome. Material and Methods: Our study included 64 patients who were clinically and/or histopathologically diagnosed with EM, SJS, and SJS/TEN overlap syndrome and 66 healthy control subjects who were genotyped for the MBL2 gene codon 54 polymorphism using the PCR-RFLP method. For all statistical analyses, the level of significance was set at p<0.05. Results: The prevalence of the B allele was 18% in the EM, SJS and SJS/TEN patient groups and 13% in the control group. No significant differences in allele frequencies of any polymorphism were observed between the patient and control groups, although the B allele was more frequent in the patient groups (p=0.328.Conclusion: Our results provide no evidence of a relationship between MBL2 gene codon 54 polymorphism and the susceptibility to EM, SJS and SJS/TEN overlap syndrome. However, these findings should be confirmed in studies with a larger sample size.

  3. Stevens Johnson Syndrome in a patient undergoing gynaecological brachytherapy: An association or an incident?

    International Nuclear Information System (INIS)

    Ferreira, M. R.; Amado, A.; Jorge, M.; Grillo, I. M.

    2011-01-01

    Background: Stevens Johnson Syndrome and Erythema Multiforme are hypersensitivity skin reactions generally arising in the context of multiple causes. Radiation therapy is considered to be one of these causes, although most reports are hindered by concomitant medications. Aim: The aim of this paper was to present a case of Stevens Johnson Syndrome arising in a patient undergoing gynaecological brachytherapy with an unusual presentation. Case:We describe a case of a 56-year-old woman with endometrial cancer undergoing adjuvant gynaecological radiotherapy. While undergoing a gynaecological brachytherapy boost, she developed bilateral conjunctivitis that progressed to oral mucositis and pruritic erythema with sloughing of the skin on her arms and legs but not the torso or irradiated fields (namely the vaginal mucosa). Conclusion: This case illustrates the association of RT/SJS; however, it also raises the question of patients undergoing RT being more susceptible to SJS as opposed to a direct cause of the disease. (authors)

  4. Design as dream and self-representation: Philip Johnson and the Glass House of Atreus.

    Science.gov (United States)

    Tutter, Adele

    2011-06-01

    Philip Johnson's masterpiece--the Glass House--is compared to a dream and conceptualized as containing encrypted and embedded representations of the self. Freud's masterpiece--The Interpretation of Dreams--is the theoretical and methodological model for this approach to design-as-dream. Drawing on Johnson's words and forms set in biographical, historical, and cultural context, interpretive paths are traced from manifest design elements of the Glass House to overdetermined latent meanings, yielding new and surprising insights into the Glass House, its elusive architect, and the process of its design. A mirror that reflects an image, a lens that focuses it, and a prism that reveals its components, the Glass House turns a lucid eye onto its maker.

  5. The Johnson Space Center management information systems: User's guide to JSCMIS

    Science.gov (United States)

    Bishop, Peter C.; Erickson, Lloyd

    1990-01-01

    The Johnson Space Center Management Information System (JSCMIS) is an interface to computer data bases at the NASA Johnson Space Center which allows an authorized user to browse and retrieve information from a variety of sources with minimum effort. The User's Guide to JSCMIS is the supplement to the JSCMIS Research Report which details the objectives, the architecture, and implementation of the interface. It is a tutorial on how to use the interface and a reference for details about it. The guide is structured like an extended JSCMIS session, describing all of the interface features and how to use them. It also contains an appendix with each of the standard FORMATs currently included in the interface. Users may review them to decide which FORMAT most suits their needs.

  6. [Stevens-Johnson syndrome followed by Gougerot-Sjögren syndrome].

    Science.gov (United States)

    de Roux Serratrice, C; Serratrice, J; Granel, B; Weiller-Merli, C; Rey, J; Lepidi, H; Disdier, P; Weiller, P J

    2001-03-24

    Sicca syndrome after Stevens-Johnson syndrome is classically described. However, to our knowledge, authentic Sjögren's syndrome following epidermal necrolysis has not been described previously. A 36-year-old woman with Steven-Johnson syndrome developed transient hepatitis and a persistent sicca syndrome. Fourteen years later an authentic Sjögren's syndrome was identified with presence of antinuclear and anti-SSA antibodies and lymphocytes infiltration of the accessory salivary glands, i.e. grade IV disease in the Chisholm classification. The initial mucosal destruction observed in our patients may have laid the ground for Sjögren's syndrome via abnormal antigen presentation in a predisposed dysimmune context.

  7. Spaceflight Radiation Health program at the Lyndon B. Johnson Space Center

    International Nuclear Information System (INIS)

    Johnson, A.S.; Badhwar, G.D.; Golightly, M.J.; Hardy, A.C.; Konradi, A.; Yang, T.C.

    1993-12-01

    The Johnson Space Center leads the research and development activities that address the health effects of space radiation exposure to astronaut crews. Increased knowledge of the composition of the environment and of the biological effects of space radiation is required to assess health risks to astronaut crews. The activities at the Johnson Space Center range from quantification of astronaut exposures to fundamental research into the biological effects resulting from exposure to high energy particle radiation. The Spaceflight Radiation Health Program seeks to balance the requirements for operational flexibility with the requirement to minimize crew radiation exposures. The components of the space radiation environment are characterized. Current and future radiation monitoring instrumentation is described. Radiation health risk activities are described for current Shuttle operations and for research development program activities to shape future analysis of health risk

  8. Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report

    Directory of Open Access Journals (Sweden)

    Kodliwadmath A

    2017-07-01

    Full Text Available Ashwin Kodliwadmath Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India Abstract: Stevens–Johnson syndrome (SJS is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and mortality. Here, we describe the case of a 43-year-old male who developed SJS and myocarditis secondary to phenytoin. In spite of aggressive resuscitative efforts, the patient could not be revived. Thus, a combination of myocarditis with SJS increases the mortality and should be considered in patients with SJS secondary to phenytoin and associated shock. Keywords: phenytoin, myocarditis, Stevens–Johnson syndrome

  9. STEVENS–JOHNSON SYNDROME — TOXIC EPIDERMAL NECTROLYSIS IN CHILDREN. PART II. SYSTEM, LOCAL TREATMENT

    Directory of Open Access Journals (Sweden)

    V.F. Zhernosek

    2011-01-01

    Full Text Available The second part of the article concerning Stevens–Johnson syndrome — toxic epidermal necrolysis (SJS–TEN is devoted to the treatment of this disease. The modern approaches to the use of systemic agents — antibacterial, antiviral, analgesics and sedatives, and anticoagulants are discussed in detail. Regulations of the drugs use depending on the patient state and the etiology of SJS–TEN are marked out. The basic principles of the fluid therapy for rehydration and dehydration prevention are shown in the article. Particular attention is paid to the local therapy — treatment of mucous membranes and skin lesions.Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, children, antibiotic therapy, topical treatment.

  10. Fatal Stevens-Johnson syndrome/toxic epidermal necrolysis induced by allopurinol-rituximab-bendamustine therapy.

    Science.gov (United States)

    Fallon, Michael J; Heck, Jessica N

    2015-10-01

    Stevens-Johnson syndrome/toxic epidermal necrolysis overlap is an acute hypersensitivity reaction that compromises the integrity of mucous membranes and cutaneous tissue. While the pathophysiology of this syndrome has not been fully elucidated, it is commonly associated with the medication use and carries a significant mortality risk of approximately 30%. No commonalities among causative medications have been identified, and determining the offending agent can be challenging. This case report describes fatal Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a patient after receiving his first cycle of allopurinol, rituximab, and bendamustine treatment for non-Hodgkin's B-cell lymphoma. An analysis of FDA Medwatch adverse reaction case reports involving allopurinol, rituximab, and bendamustine is also presented. © The Author(s) 2014.

  11. Concurrence of Stevens-Johnson Syndrome and Bilateral Parotitis after Minocycline Therapy

    Directory of Open Access Journals (Sweden)

    Jimi Yoon

    2010-06-01

    Full Text Available Minocycline is an antibiotic of tetracycline derivatives that is commonly used in the treatment of moderate to severe acne vulgaris. It has been reported to cause rare adverse events from mild cutaneous eruption to severe forms including drug-induced lupus, serum sickness-like reaction, and hypersensitivity reactions, etc. The risks of adverse events attributed to minocycline have not been ascertained reliably and there are concerns about the safety of minocycline which could possibly result in life-threatening events such as the Stevens-Johnson syndrome. Here we demonstrate an unusual case of Stevens-Johnson syndrome in conjunction with bilateral parotitis after the intake of minocycline in a Korean boy suggesting discreet use of the drug.

  12. An evaluation of the Johnson-Cook model to simulate puncture of 7075 aluminum plates.

    Energy Technology Data Exchange (ETDEWEB)

    Corona, Edmundo; Orient, George Edgar

    2014-02-01

    The objective of this project was to evaluate the use of the Johnson-Cook strength and failure models in an adiabatic finite element model to simulate the puncture of 7075- T651 aluminum plates that were studied as part of an ASC L2 milestone by Corona et al (2012). The Johnson-Cook model parameters were determined from material test data. The results show a marked improvement, in particular in the calculated threshold velocity between no puncture and puncture, over those obtained in 2012. The threshold velocity calculated using a baseline model is just 4% higher than the mean value determined from experiment, in contrast to 60% in the 2012 predictions. Sensitivity studies showed that the threshold velocity predictions were improved by calibrating the relations between the equivalent plastic strain at failure and stress triaxiality, strain rate and temperature, as well as by the inclusion of adiabatic heating.

  13. Water quality of streams in Johnson County, Kansas, 2002-07

    Science.gov (United States)

    Rasmussen, T.J.

    2009-01-01

    Water quality of streams in Johnson County, Kansas was evaluated from October 2002 through December 2007 in a cooperative study between the U.S. Geological Survey and the Johnson County Stormwater Management Program. Water quality at 42 stream sites, representing urban and rural basins, was characterized by evaluating benthic macroinvertebrates, water (discrete and continuous data), and/or streambed sediment. Point and nonpoint sources and transport were described for water-quality constituents including suspended sediment, dissolved solids and major ions, nutrients (nitrogen and phosphorus), indicator bacteria, pesticides, and organic wastewater and pharmaceutical compounds. The information obtained from this study is being used by city and county officials to develop effective management plans for protecting and improving stream quality. This fact sheet summarizes important results from three comprehensive reports published as part of the study and available on the World Wide Web at http://ks.water.usgs.gov/Kansas/studies/qw/joco/. ?? 2009 ASCE.

  14. Os relatórios Masters & Johnson: gênero e as práticas psicoterapêuticas sexuais a partir da década de 70 The Masters & Johnson's reports: gender and the sexual psychotherapy practices as of the 1970s

    Directory of Open Access Journals (Sweden)

    Tito Sena

    2010-04-01

    Full Text Available Este trabalho é o resultado de uma análise sobre os relatórios Masters & Johnson, editados originalmente nos anos de 1966 (A Resposta Sexual Humana e 1970 (A Inadequação Sexual Humana. Os relatórios analisados, produzidos nos Estados Unidos e com repercussão mundial, foram elaborados a partir de uma minuciosa investigação científica das respostas fisiológicas e anatômicas da sexualidade masculina e feminina. Os autores, em decorrência, utilizaram esses conhecimentos para a formulação de técnicas e tratamento em terapia sexual utilizadas até hoje por profissionais da área clínica. Os relatórios Masters & Johnson emergiram com a proposta de preencher as lacunas médicas, fisiológicas e psicológicas diante das pesquisas estatísticas comportamentais de Alfred Kinsey (1948 e 1953. A obra de M&J se apresenta abertamente como uma defesa do casamento monogâmico heterossexual, e com elaborações atravessadas por questões de gênero. Partindo do instrumental teórico de Michel Foucault, verifica-se serem exemplares da prática de uma scientia sexualis, que procura instituir uma verdade no sexo e do sexo.This work is the result of an analysis on the Masters & Johnson's Reports, originally published in 1966 (Human Sexual Response and 1970 (The Human Sexual Inadequacy. The reports investigated, produced in the United States and spread worldwide, were prepared based on a careful, scientific investigation of the physiologic and anatomic responses of male and female sexuality. The authors used the results to formulate techniques and treatment in sexual therapy, which are so far in use by professionals in the clinical area. The Masters & Johnson's reports came with the proposal of filling the medical, physiological and psychological gaps left by the behaviorist statistics research by Alfred Kinsey (1948 and 1953. M&J's work defends openly the heterosexual monogamist marriage, with elaborations mingled with gender questions. From the

  15. Phenytoin induced Steven–Johnson syndrome and bronchiolitis obliterans – case report and review of literature

    OpenAIRE

    Pannu, Bibek S.; Egan, Ashley M.; Iyer, Vivek N.

    2016-01-01

    Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are both rare but serious idiosyncratic drug reactions characterized by diffuse muco-epidermoid injury and high mortality. Keratinocytes in both skin and mucous membranes (including eyes, mouth and genitalia) are injured resulting in a diffuse maculopapular rash, blistering lesions and epithelial detachment with minimal force (Nikolsky's sign). SJS is typically diagnosed when less than 10% of the skin surface is involved and ...

  16. Applied human factors research at the NASA Johnson Space Center Human-Computer Interaction Laboratory

    Science.gov (United States)

    Rudisill, Marianne; Mckay, Timothy D.

    1990-01-01

    The applied human factors research program performed at the NASA Johnson Space Center's Human-Computer Interaction Laboratory is discussed. Research is conducted to advance knowledge in human interaction with computer systems during space crew tasks. In addition, the Laboratory is directly involved in the specification of the human-computer interface (HCI) for space systems in development (e.g., Space Station Freedom) and is providing guidelines and support for HCI design to current and future space missions.

  17. Peristaltic transport of Johnson-Segalman fluid under effect of a magnetic field

    Directory of Open Access Journals (Sweden)

    Moustafa Elshahed

    2005-01-01

    Full Text Available The peristaltic transport of Johnson-Segalman fluid by means of an infinite train of sinusoidal waves traveling along the walls of a two-dimensional flexible channel is investigated. The fluid is electrically conducted by a transverse magnetic field. A perturbation solution is obtained for the case in which amplitude ratio is small. Numerical results are reported for various values of the physical parameters of interest.

  18. Estimating the Parameters of the Johnson's SB Distribution Using an Approach of Method of Moments

    Science.gov (United States)

    Mateus, Ayana; Tomé, Margarida

    2011-09-01

    In this paper, Johnson SB distribution is used to model the diameter distribution of Eucalyptus globulus in Portugal. We present a new methodology to estimate the parameters of the distribution, where we develop a system of equations that relates stand characteristics with the non-central moments of the distribution. This way, we assure that the estimates obtained observe some restrictions which will enable them to keep a sensible biological meaning.

  19. Institutionalism and culture in strategies of multinational firms: the case of Johnson controls Inc.

    Directory of Open Access Journals (Sweden)

    José G. Vargas-Hernández

    2013-07-01

    Full Text Available The aim of this paper is to analyze both the internal and external aspects that may pose a risk to the operations of the subsidiaries of the multinational Johnson Controls Inc. in the U.S. and Mexico from an institutional point of view. The main challenges are the impact in the achievement of goals both of workers and of the same organization and the influence institutions have on the organizational environment, for the decommissioning of some branch/ subsidiary.

  20. Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases.

    Science.gov (United States)

    Balasundaram, S; Ranganathan, K; Umadevi, K; Gunaseelan, R; Kumaraswamy, N; Solomon, Sunithi; Devaleenol, Bella; Ambrose, Pradeep

    2011-01-01

    Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.

  1. Fox-Fordyce Disease after Steven-Johnson Syndrome: case report

    Directory of Open Access Journals (Sweden)

    Havva Yildiz Seckin

    2016-09-01

    Full Text Available Fox-Fordyce Disease (FFD is a rare, chronic disorder of the apocrin sweat glands and characterized by pruritic papules. The disease primarily affects females and the etiology is unclear. A 19-year-old male patient developed FFD in his lips with a history of Steven-Johnson Syndrome is presented in this report. [J Contemp Med 2016; 6(3.000: 214-217

  2. Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case

    OpenAIRE

    Avinash, A.; Amberkar, V. Mohanbabu; Kunder, Sushil Kiran; Madhyastha, Sharath; Meenakumari, K.

    2016-01-01

    Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or funga...

  3. Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report

    OpenAIRE

    Kodliwadmath A

    2017-01-01

    Ashwin Kodliwadmath Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India Abstract: Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to incre...

  4. Antiepileptic Drugs-induced Stevens?Johnson syndrome: A case Series

    OpenAIRE

    Trivedi, Bhavi S.; Darji, Nishita H.; Malhotra, Supriya D.; Patel, Pankaj R.

    2016-01-01

    Stevens?Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with car...

  5. Pediatric Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Halted by Etanercept.

    Science.gov (United States)

    Gavigan, Geneviève M; Kanigsberg, Nordau D; Ramien, Michele L

    2018-02-01

    We report a case of an 11-year-old female with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) overlap, most likely triggered by sulfamethoxazole-trimethoprim, who was treated with the combination of methylprednisolone, cyclosporine, and etanercept. Her condition stabilized and her skin involvement did not progress after the addition of etanercept. To our knowledge, this is the first report of etanercept for pediatric SJS/TEN.

  6. Mycoplasma Pneumoniae with Atypical Stevens-Johnson Syndrome: A Diagnostic Challenge

    Directory of Open Access Journals (Sweden)

    Ralph Yachoui

    2013-01-01

    Full Text Available The Stevens-Johnson syndrome (SJS classically involves a targetoid skin rash and the association of the oral mucosa, genitals, and conjunctivae. Recently, there have been several documentations of an incomplete presentation of this syndrome, without the typical rash, usually associated with the mycoplasma pneumoniae infection. Our case illustrates that this important clinical diagnosis should not be missed due to its atypical presentation.

  7. Characterization of thermal transport in one-dimensional microstructures using Johnson noise electro-thermal technique

    Science.gov (United States)

    Liu, Jing; Wang, Xinwei

    2015-06-01

    This work reports on the development of a Johnson noise electro-thermal (JET) technique to directly characterize the thermal conductivity of one-dimensional micro-/nanoscale materials. In this technique, the to-be-measured micro-/nanoscale sample is connected between two electrodes and is subjected to steady-state Joule heating. The average temperature rise of the sample is evaluated by simultaneously measuring the Johnson noise over it and its electrical resistance. The system's Johnson noise measurement accuracy is evaluated by measuring the Boltzmann constant ( k B). Our measured k B value (1.375 × 10-23 J/K) agrees very well with the reference value of 1.381 × 10-23 J/K. The temperature measurement accuracy based on Johnson noise is studied against the resistance temperature detector method, and sound agreement (4 %) is obtained. The thermal conductivity of a glass fiber with a diameter of 8.82 μm is measured using the JET technique. The measured value 1.20 W/m K agrees well with the result using a standard technique in our laboratory. The JET technique provides a very compelling way to characterize the thermophysical properties of micro-/nanoscale materials without calibrating the sample's resistance-temperature coefficient, thereby eliminating the effect of resistance drift/change during measurement and calibration. Since JET technique does not require resistance-temperature correlation, it is also applicable to semi-conductive materials which usually have a nonlinear I- V relation.

  8. Síndrome de Stevens-Johnson: Presentación de 1 caso

    Directory of Open Access Journals (Sweden)

    Luisa María Pacheco Álvarez

    2001-12-01

    Full Text Available El síndrome de Stevens-Johnson, es una enfermedad inflamatoria aguda, originada por una hipersensibilidad, que incluye la piel y las membranas mucosas; en una forma mayor pone en peligro la vida del paciente. Puede ser inducida por muchos factores precipitantes, desde los medicamentos hasta una infección. La afección se caracteriza por una súbita erupción morfológicamente variable, acompañada de estomatitis y oftalmia. En este trabajo se presenta un niño de 8 años de edad, con la entidad clínica en forma muy severa, el síndrome de Stevens-Johnson, que involucra manifestaciones cutáneas, oculares y de la mucosa oral, acompañada de otras complicaciones graves, por lo que requirió terapéutica en cuidados intensivos, y se logró una evolución satisfactoria del paciente.Stevens-Johnson syndrome is an acute inflammatory disease caused by a hypersensibility that includes the skin and the mucous membranes and that in a severe form endangers the patient’s life. It may be induced by many precipitating factors, from drugs to infection. The affection is characterized by a sudden morphologically variable rash, accompanied with stomatitis and ophthalmia. An 8-year-old boy suffering from this clinical entity in a very severe form, Stevens-Johnson syndrome, with skin , ocular and oral mucosa manifestations and with other serious complications, is presented in this paper. He had to be treated at the ICU and a satisfactory evolution was attained.

  9. Installation Restoration Program. Phase I. Records Search. Seymour Johnson Air Force Base, North Carolina.

    Science.gov (United States)

    1982-07-01

    SQUADRON1 Closed Circuit TV Shop 2904 Computer Maintenance 3500 Crypto Maintenance 2904 (1) Aerospace Ground Equipment I4 4-9 -!~------ TABLE 4.2 INDUSTRIAL...Disposal Name (Bldg. No) Materials Wastes Method(s) 2012 CS (Continued) Computer Maintenance 3500 no no Crypto Maintenance 2904 no no Navig. Aids 4745...Area DATE OF OPERATION OR O( CURRENCE 1971 to Present OWNER/OPERATOR Seymour Johnson AFB comanS/s/Dcu zmom Received Base Refuse through 1978, still open

  10. Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome

    OpenAIRE

    Burkhart, Keith K.; Abernethy, Darrell; Jackson, David

    2015-01-01

    Drug features that are associated with Stevens-Johnson syndrome (SJS) have not been fully characterized. A molecular target analysis of the drugs associated with SJS in the FDA Adverse Event Reporting System (FAERS) may contribute to mechanistic insights into SJS pathophysiology. The publicly available version of FAERS was analyzed to identify disproportionality among the molecular targets, metabolizing enzymes, and transporters for drugs associated with SJS. The FAERS in-house version was al...

  11. Left main percutaneous coronary intervention.

    Science.gov (United States)

    Teirstein, Paul S; Price, Matthew J

    2012-10-23

    The introduction of drug-eluting stents and advances in catheter techniques have led to increasing acceptance of percutaneous coronary intervention (PCI) as a viable alternative to coronary artery bypass graft (CABG) for unprotected left main disease. Current guidelines state that it is reasonable to consider unprotected left main PCI in patients with low to intermediate anatomic complexity who are at increased surgical risk. Data from randomized trials involving patients who are candidates for either treatment strategy provide novel insight into the relative safety and efficacy of PCI for this lesion subset. Herein, we review the current data comparing PCI with CABG for left main disease, summarize recent guideline recommendations, and provide an update on technical considerations that may optimize clinical outcomes in left main PCI. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  12. Left bundle-branch block

    DEFF Research Database (Denmark)

    Risum, Niels; Strauss, David; Sogaard, Peter

    2013-01-01

    The relationship between myocardial electrical activation by electrocardiogram (ECG) and mechanical contraction by echocardiography in left bundle-branch block (LBBB) has never been clearly demonstrated. New strict criteria for LBBB based on a fundamental understanding of physiology have recently...

  13. Dabigatran for left ventricular thrombus

    Directory of Open Access Journals (Sweden)

    Satishkumar Kolekar

    2015-09-01

    Dabigatran is a reversible direct thrombin inhibitor and currently approved for the prevention of thromboembolic episodes in non-valvar atrial fibrillation. This case demonstrates possible thrombolytic properties of dabigatran in resolution of left ventricular thrombus.

  14. [Scleral contact lens for ocular rehabilitation in patients with Stevens-Johnson syndrome].

    Science.gov (United States)

    Siqueira, Ana Carolina Punzi de; Santos, Myrna Serapião dos; Farias, Charles Costa de; Barreiro, Telma Regina Maria Pereira; Gomes, José Álvaro Pereira

    2010-01-01

    To evaluate the efficacy of scleral contact lenses use on the management of ocular sequelae from Stevens-Johnson syndrome patients. In a retrospective study, patients who suffered sequelae of Stevens-Johnson syndrome and started the use of scleral contact lenses were followed. Patients were submitted to an evaluation of symptoms through a questionnaire; ophthalmologic exam (visual acuity measurement, biomicroscopy, ocular surface staining with fluorescein drops, Schirmer test). Ten eyes of seven patients were analyzed. Visual acuity varied from hand movements to 20/25. All patients presented some degree of corneal opacity and slight symblepharon. In patients whose adaptation to scleral contact lenses was successful (90%), they all refered improvement of symptoms and sight. As for the biomicroscopic findings it was observed an improvement of conjunctival hyperemia and keratitis and a reduction of the mucous secretion in 90% the cases. A successful adaptation to scleral contact lenses was feasible on most patients, with relief of symptoms and better visual acuity, probably due to regularization of the surface. Scleral contact lenses represent an important and accessible alternative to reduce the limitations inferred by the damages from Stevens-Johnson syndrome.

  15. Stevens-Johnson syndrome caused by a health drink (Eberu) containing ophiopogonis tuber.

    Science.gov (United States)

    Mochitomi, Y; Inoue, A; Kawabata, H; Ishida, S; Kanzaki, T

    1998-10-01

    Stevens-Johnson syndrome is considered to be a severe type of erythema exsudativum multiforme. It is characterized by erythema with bullous and eroded lesions of skin and mucous membranes. We report a case of Steven-Johnson syndrome following consumption of a health drink containing ophiopogonis tuber. A 66-year-old female took an O.T.C. health drink for fever. The next morning, she noted erythema and swelling of her face, neck, and chest. She started to develop bullous and eroded lesions on the skin of her entire body and the mucous membranes of her oral cavity, conjunctiva, and cornea, and she became feverish. She had high degrees of corneal erosion and liver dysfunction. Skin biopsy showed diffuse necrosis of the epidermis. After admission to the hospital, steroid pulse therapy (1000 mg/day of methylprednisolone sodium succinate) was continued for 5 days. The health drink induced a positive drug lymphocyte stimulation test (DLST) and patch test. A challenge test was done with a one hundredth dose, and it was positive. We did patch tests with all components of the drink and found that Mai-Meu-Dong-Tang (ophiopogonis) alone was positive at 72 hours. There is no previous report of Stevens-Johnson syndrome caused by a health drink or Mai-Meu-Dong-Tang. Even though it is a health drink, we should be aware of the possibility of a severe reaction.

  16. Johnson-Nyquist noise and the Casimir force between real metals at nonzero temperature

    International Nuclear Information System (INIS)

    Bimonte, Giuseppe

    2008-01-01

    It has been well known for a long time that all lossy conductors at finite temperature display an electronic noise, the Johnson-Nyquist noise, arising from the thermal agitation of electric charges inside the conductor. The existence of this noise implies that two nearby discharged conductors at finite temperature should repel each other, as a result of the electrodynamic interaction between the Johnson-Nyquist currents in either conductor and the eddy currents they induce in the other. It is suggested that this force is at the origin of the recently discovered large repulsive correction to the thermal Casimir force between two lossy metallic plates. Further support for this physical picture is obtained by studying a simple system of two linear noisy antennas. Using elementary concepts from circuit theory, we show that the repulsive force engendered by the Johnson-Nyquist noise results in the same kind of thermodynamic inconsistencies found in the Casimir problem. We show that all inconsistencies are however resolved if account is taken of capacitive effects associated with the end points of the antennas. Our findings therefore suggest that capacitive effects resulting from the finite size of the plates may be essential for a resolution of the analogous problems met in the thermal Casimir effect

  17. Deviasi Taksiran Berat Janin pada Metode Johnson-Toshack, Formula Sederhana dan Formula Dare

    Directory of Open Access Journals (Sweden)

    Emy Rianti

    2017-08-01

    Full Text Available The ability of the birth attendant to estimate the birth weight of the fetus is very important that it does not cause childbirth dystocia that may cause rip in the birth canal. The aim of this study was to compare the deviation of fetal weight estimation according to Johnson-Toshack method, simple formula and Dare formula. Thedesign used was cross sectional, the data taken primarily, involving 100 respondents at Fatmawati General Hospital Jakarta, from August to September 2015. The findings showed that the smallest deviation mean of fetal weight estimation is Johnson-Toshack method. The results of this method of measurement tend to be close to infant birth weight, especially in the client childbirth with abdominal circumference 90 - 100 cm. The conclusion of this study is that Johnson-Toshack's fetal weighing estimates are more appropriate for childbirth with 90 to 100 cm abdominal circumference size, except in childbirth with ruptured membranes, applying a fetal weight estimate based on the Dare formula would be more appropriate.

  18. Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals*

    Science.gov (United States)

    Arantes, Luana Bernardes; Reis, Carmélia Santiago; Novaes, Alice Garbi; de Carvalho, Marta Rodrigues; Göttems, Leila Bernarda Donato; Novaes, Maria Rita Carvalho Garbi

    2017-01-01

    Background Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. Objectives To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Methods Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. Limitations of the study There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. Conclusion There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions. PMID:29166503

  19. Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.

    Science.gov (United States)

    Arantes, Luana Bernardes; Reis, Carmélia Santiago; Novaes, Alice Garbi; Carvalho, Marta Rodrigues de; Göttems, Leila Bernarda Donato; Novaes, Maria Rita Carvalho Garbi

    2017-01-01

    Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions.

  20. [Stevens-Johnson syndrome and Hodgkin's disease: A fortuitous association or paraneoplastic syndrome?].

    Science.gov (United States)

    Schoeffler, A; Levy, E; Weinborn, M; Cuny, J-F; Schmutz, J-L; Barbaud, A; Cribier, B; Bursztejn, A-C

    2014-02-01

    Hodgkin's disease has been associated with a variety of cutaneous symptoms. We report two cases of Stevens-Johnson syndrome (SJS) associated with Hodgkin's disease. Case 1: a 22-year-old man was hospitalized for a second erythematous vesicular eruption with intense mucosal involvement. Histopathological examination confirmed the diagnosis of Stevens-Johnson syndrome. He also developed enlarged cervical lymph nodes that revealed Hodgkin's disease. The latter diagnosis was followed by two recurrent rashes. Treatment consisted of systemic chemotherapy. Complete remission was obtained with no signs of cutaneous recurrence after 24 months of regular follow-up. Case 2: a 29-year-old man was admitted for a generalized erythematous and bullous rash with intense mucosal involvement. Histopathological examination confirmed the diagnosis of Stevens-Johnson syndrome. He then developed muco-cutaneous icterus that was secondary to Hodgkin's disease. Under specific hematologic treatment, no cutaneous relapse was noticed. These cases illustrate the rare association of SSJ revealing Hodgkin's disease. In these cases, no evidence was found of infectious disease or drug-induced cutaneous effects. Only one case of toxic epidermal necrolysis associated with Hodgkin's disease had previously been reported. The link between both diseases may be immunosuppression induced by Hodgkin's disease, which could favor infection inducing SJS or secretion by tumor cells granulysin, a mediator responsible for damage to keratinocytes. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  1. The Finite Strain Johnson Cook Plasticity and Damage Constitutive Model in ALEGRA.

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Jason James [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2018-02-01

    A finite strain formulation of the Johnson Cook plasticity and damage model and it's numerical implementation into the ALEGRA code is presented. The goal of this work is to improve the predictive material failure capability of the Johnson Cook model. The new implementation consists of a coupling of damage and the stored elastic energy as well as the minimum failure strain criteria for spall included in the original model development. This effort establishes the necessary foundation for a thermodynamically consistent and complete continuum solid material model, for which all intensive properties derive from a common energy. The motivation for developing such a model is to improve upon ALEGRA's present combined model framework. Several applications of the new Johnson Cook implementation are presented. Deformation driven loading paths demonstrate the basic features of the new model formulation. Use of the model produces good comparisons with experimental Taylor impact data. Localized deformation leading to fragmentation is produced for expanding ring and exploding cylinder applications.

  2. A Modified Johnson Cook Constitutive Model for Aermet 100 at Elevated Temperatures

    Science.gov (United States)

    Zhanwei, Yuan; Fuguo, Li; Guoliang, Ji

    2018-01-01

    The predicted flow behaviors of Aermet 100 steel were analyzed within a wide range of temperatures of 1,073 K-1,473 K and strain rates of 0.01 s-1-50 s-1 based on isothermal compression tests. Using the original Johnson Cook (JC) model and a modified Johnson Cook (MJC) model, the constitutive equations were constructed in the case of elevated temperatures. For both the JC and MJC, and the previously studied (Arrhenius-type model and double-multivariate nonlinear regression (DMNR)) models, their respective predictability levels were evaluated by contrasting both the correlation coefficient R and the average absolute relative error (AARE). The results showed that the prediction from the three models meet the accuracy requirement based on the experimental data, the only exception being the JC model. By comparing the predictability and numbers of material constants involved, the modified Johnson Cook model is regarded as an excellent choice for predicting the flow behaviors of Aermet 100 steel within the range being studied.

  3. Johnson Nyquist noise and the Casimir force between real metals at nonzero temperature

    Science.gov (United States)

    Bimonte, Giuseppe

    2008-04-01

    It has been well known for a long time that all lossy conductors at finite temperature display an electronic noise, the Johnson-Nyquist noise, arising from the thermal agitation of electric charges inside the conductor. The existence of this noise implies that two nearby discharged conductors at finite temperature should repel each other, as a result of the electrodynamic interaction between the Johnson-Nyquist currents in either conductor and the eddy currents they induce in the other. It is suggested that this force is at the origin of the recently discovered large repulsive correction to the thermal Casimir force between two lossy metallic plates. Further support for this physical picture is obtained by studying a simple system of two linear noisy antennas. Using elementary concepts from circuit theory, we show that the repulsive force engendered by the Johnson-Nyquist noise results in the same kind of thermodynamic inconsistencies found in the Casimir problem. We show that all inconsistencies are however resolved if account is taken of capacitive effects associated with the end points of the antennas. Our findings therefore suggest that capacitive effects resulting from the finite size of the plates may be essential for a resolution of the analogous problems met in the thermal Casimir effect.

  4. Apraxia in left-handers.

    Science.gov (United States)

    Goldenberg, Georg

    2013-08-01

    In typical right-handed patients both apraxia and aphasia are caused by damage to the left hemisphere, which also controls the dominant right hand. In left-handed subjects the lateralities of language and of control of the dominant hand can dissociate. This permits disentangling the association of apraxia with aphasia from that with handedness. Pantomime of tool use, actual tool use and imitation of meaningless hand and finger postures were examined in 50 consecutive left-handed subjects with unilateral hemisphere lesions. There were three aphasic patients with pervasive apraxia caused by left-sided lesions. As the dominant hand is controlled by the right hemisphere, they constitute dissociations of apraxia from handedness. Conversely there were also three patients with pervasive apraxia caused by right brain lesions without aphasia. They constitute dissociations of apraxia from aphasia. Across the whole group of patients dissociations from handedness and from aphasia were observed for all manifestations of apraxia, but their frequency depended on the type of apraxia. Defective pantomime and defective tool use occurred rarely without aphasia, whereas defective imitation of hand, but not finger, postures was more frequent after right than left brain damage. The higher incidence of defective imitation of hand postures in right brain damage was mainly due to patients who had also hemi-neglect. This interaction alerts to the possibility that the association of right hemisphere damage with apraxia has to do with spatial aptitudes of the right hemisphere rather than with its control of the dominant left hand. Comparison with data from right-handed patients showed no differences between the severity of apraxia for imitation of hand or finger postures, but impairment on pantomime of tool use was milder in apraxic left-handers than in apraxic right-handers. This alleviation of the severity of apraxia corresponded with a similar alleviation of the severity of aphasia as

  5. Left ventricular apical ballooning syndrome

    International Nuclear Information System (INIS)

    Rahman, N.; Tai, J.; Soofi, A.

    2007-01-01

    The transient left ventricular apical ballooning syndrome, also known as Takotsubo cardiomyopathy, is characterized by transient left ventricular dysfunction in the absence of obstructive epicardial coronary disease. Although the syndrome has been reported in Japan since 1990, it is rare in other regions. Rapid recognition of the syndrome can modify the diagnostic and therapeutic attitude i.e. avoiding thrombolysis and performing catheterization in the acute phase. (author)

  6. Fire Hydrants, Both public and private fire hydrants in Johnson County. Spring Hill is hte only entity missing. Data is limited to CUE (Collaborative Utiity Exchange) Participants and subcontractors of them., Published in 2004, Johnson County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Fire Hydrants dataset current as of 2004. Both public and private fire hydrants in Johnson County. Spring Hill is hte only entity missing. Data is limited to CUE...

  7. Left Main Coronary Artery Aneurysm

    Directory of Open Access Journals (Sweden)

    Hossein Doustkami

    2016-07-01

    Full Text Available Aneurysms of the left main coronary artery are exceedingly rare clinical entities, encountered incidentally in approximately 0.1% of patients who undergo routine angiography. The most common cause of coronary artery aneurysms is atherosclerosis. Angiography is the gold standard for diagnosis and treatment. Depending on the severity of the coexisting coronary stenosis, patients with left main coronary artery aneurysms can be effectively managed either surgically or pharmacologically. We herein report a case of left main coronary artery aneurysm in a 72-year-old man with a prior history of hypertension presenting to our hospital because of unstable angina. The electrocardiogram showed ST-segment depression and T-wave inversion in the precordial leads. All the data of blood chemistry were normal. Echocardiography showed akinetic anterior wall, septum, and apex, mild mitral regurgitation and ejection fraction of 45%. Coronary angiography revealed a saccular aneurysm of the left main coronary artery with significant stenosis in the left anterior descending, left circumflex, and right coronary artery. The patient immediately underwent coronary artery bypass grafting and ligation of the aneurysm. At six months’ follow-up, he remained asymptomatic.

  8. Right colon cancer: Left behind.

    Science.gov (United States)

    Gervaz, P; Usel, M; Rapiti, E; Chappuis, P; Neyroud-Kaspar, I; Bouchardy, C

    2016-09-01

    Prognosis of colon cancer (CC) has steadily improved during the past three decades. This trend, however, may vary according to proximal (right) or distal (left) tumor location. We studied if improvement in survival was greater for left than for right CC. We included all CC recorded at the Geneva population-based registry between 1980 and 2006. We compared patients, tumor and treatment characteristics between left and right CC by logistic regression and compared CC specific survival by Cox models taking into account putative confounders. We also compared changes in survival between CC location in early and late years of observation. Among the 3396 CC patients, 1334 (39%) had right-sided and 2062 (61%) left-sided tumors. In the early 1980s, 5-year specific survival was identical for right and left CCs (49% vs. 48%). During the study period, a dramatic improvement in survival was observed for patients with left-sided cancers (Hazard ratio [HR]: 0.42, 95% confidence interval [CI]: 0.29-0.62, p colon cancer patients, those with right-sided lesions have by far the worse prognosis. Change of strategic management in this subgroup is warranted. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Stevens-Johnson Syndrome Patient Received Combination Chemotherapy Gemcitabine, Cisplatin, and 5-FU for Biliary Tract Cancer.

    Science.gov (United States)

    Aznab, Mozaffar; Khazaei, Mansour

    2016-06-01

    Stevens-Johnson syndrome has been an acute, usually self-limiting disease of the skin and mucous membranes. This case report has presented an evidence of the development Stevens - Johnson syndrome associated with combination chemotherapy administration of 5FU, gemcitabin and cisplatin in a patient with biliary tract cancer. Our case was a 54-year-old woman patient, a case of biliary tract cancer who has developed more severe symptoms of Stevens-Johnson syndrome. Diagnosis has confirmed by skin biopsy of an affected area .The patient has improved with supportive care, and during 25 day occurred recovery. Although Stevens-Johnson syndrome has been a rare toxicity, physicians should pay a special attention to the monitoring of biliary tract cancer patients on combination chemotherapy with 5FU, cisplatin and gemcitabin.

  10. Mida andis teile Tallinna ülikooli suvekoolis osalemine? / Ipios Nikos, Cheryl Johnson, Jevgenijs Kaktinš...[jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastasid arst Ipios Nikos, luteri-anglikaani vaimulik, arheoloog Cheryl Johnson, ökonomist Jevgenijs Kaktinš, filosoofia magistrant Gabriele Avincola ja filosoofia üliõpilane Kaia Otstak

  11. Síndrome de Stevens-Johnson con afectación mucosa predominante Stevens-Johnson's Syndrome with predominant mucous membrane involvement

    OpenAIRE

    S. Rekarte García; C. Montalvo Ávalos; A. López Martínez; L. Mantecón Fernández; P. Fernández González

    2012-01-01

    Introducción. El síndrome de Stevens-Johnson es una reacción idiosincrásica mucocutánea secundaria mayoritariamente a fármacos y a ciertos agentes infecciosos. En algunas ocasiones, como los dos casos que aquí se presentan, cursa con mínima afectación cutánea, predominando el compromiso mucoso en forma de ampollas, erosiones y costras. Caso clínico 1. Niño de 8 años con lesiones aftosas, vesículo-ampollosas y costrosas en mucosa oral, labial y endonasal; eritema violáceo periocular bilateral,...

  12. Aphasia following left thalamic hemorrhage

    International Nuclear Information System (INIS)

    Makishita, Hideo; Miyasaka, Motomaro; Tanizaki, Yoshio; Yanagisawa, Nobuo; Sugishita, Morihiro.

    1984-01-01

    We reported 7 patients with left thalamic hemorrhage in the chronic stage (from 1.5 months to 4.5 months), and described language disorders examined by Western Aphasia Battery (WAB) and measured cerebral blood flow by single photon emission CT. Examination of language by WAB revealed 4 aphasics out of 7 cases, and 3 patients had no language deficit. The patient with Wernicke's aphasia showed low density area only in the left posterior thalamus in X-ray CT, and revealed severe low blood flow area extending to left temporal lobe in emission CT. In the case with transcortical sensory aphasia, although X-ray CT showed no obvious low density area, emission CT revealed moderate low flow area in watershed area that involved the territory between posterior cerebral and middle cerebral arteries in the left temporooccipital region in addition to low blood flow at the left thalamus. In one of the two patients classified as anomic aphasia, whose score of repetition (8.4) was higher than that of comprehension (7.4), emission CT showed slight low flow area at the temporo-occipital region similarly as the case with transcortical sensory aphasia. In another case with anomic aphasia, scored 9 on both fluensy and comprehension subtests and 10 on repetition, there was wide low density area all over the left thalamus and midline shift to the right in X-ray CT, and emission CT showed severe low blood flow in the same region spreading widely toward the cerebral surface. On the other hand, in all of the 3 patients without aphasia, emission CT showed low flow region restricted to the left thalamus. (J.P.N.)

  13. Proceedings of the MICOM Logistics Research and Development Workshop (2nd) Held in Huntsville, Alabama on 27-28 August 1991

    Science.gov (United States)

    1991-09-01

    techniques. The Hypertext software would allow users tojump from one topic of information to a myriad of other related topics, choos - ing their own...205-876-9211 Erves, Jimmy J .................................................................. 205-842...876-3698 Johnson, Sharon M. (Speaker)............................................... 205-842-8537 Johnston, Jimmy D

  14. Evaluation of the patients diagnosed with Stevens Johnson syndrome and toxic epidermal necrolysis: a single center experience.

    Science.gov (United States)

    Çekiç, Şükrü; Canıtez, Yakup; Sapan, Nihat

    2016-09-01

    Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years. Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludağ University School of Medicine were included in this study. Clinical findings, laboratory tests and response to treatments were evaluated via electronic files. Two of the patients had Stevens-Johnson syndrome, four had Stevens-Johnson syndrome/toxic epidermal necrolysis overlap, and five had toxic epidermal necrolysis. The median period for drug usage was 10 days (2-44 days). Herpes simpleks virus IgM antibody was detected two patients. The median healing time was 38 days 26-94 days). Maculopapular eruptions and oral mucositis were seen in all patients. Vesicul or bullae, epidermal detachment and ocular involvement in 10 of patients. Wound care, H1 antihistamine and methyl prednisolon were used in all patients, intravenous immunoglobulin were used in 7 patients and cyclosporine in 1 patient. Sequel lesions developed in 2 of the patients and there was no death. Anticonvulsants, antibiotics and non steroid anti-inflammatory drugs play a major role in the etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis. Anticonvulsants are associated with severe disease. The patients with proper wound care and treatment with immunosuppressive drugs can be recovered without or with minimal sequelae.

  15. Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

    Science.gov (United States)

    Manolio, Teri A; Hutter, Carolyn M; Avigan, Mark; Cibotti, Ricardo; Davis, Robert L; Denny, Joshua C; Grenade, Lois La; Wheatley, Lisa M; Carrington, Mary N; Chantratita, Wasun; Chung, Wen-Hung; Dalton, Andrea D; Hung, Shuen-Iu; Lee, Ming Ta Michael; Leeder, J Steven; Lertora, Juan J L; Mahasirimongkol, Surakameth; McLeod, Howard L; Mockenhaupt, Maja; Pacanowski, Michael; Phillips, Elizabeth J; Pinheiro, Simone; Pirmohamed, Munir; Sung, Cynthia; Suwankesawong, Wimon; Trepanier, Lauren; Tumminia, Santa J; Veenstra, David; Yuliwulandari, Rika; Shear, Neil H

    2018-03-01

    Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs. © 2017 American Society for Clinical Pharmacology and Therapeutics.

  16. Supplemental site inspection for Air Force Plant 59, Johnson City, New York, Volume 1: Investigation report

    Energy Technology Data Exchange (ETDEWEB)

    Nashold, B.; Rosenblatt, D.; Hau, J. [and others

    1995-08-01

    This summary describes a Supplemental Site Inspection (SSI) conducted by Argonne National Laboratory (ANL) at Air Force Plant 59 (AFP 59) in Johnson City, New York. All required data pertaining to this project were entered by ANL into the Air Force-wide Installation Restoration Program Information System (IRPIMS) computer format and submitted to an appropriate authority. The work was sponsored by the United States Air Force as part of its Installation Restoration Program (IRP). Previous studies had revealed the presence of contaminants at the site and identified several potential contaminant sources. Argonne`s study was conducted to answer questions raised by earlier investigations.

  17. [The application of highly hydrophilic contact lenses in the Fuchs-Steven-Johnson syndrome (author's transl)].

    Science.gov (United States)

    Schulz, E

    1979-01-01

    In 3 patients with status after Fuchs-Steven-Johnson syndrome highly hydrophilic contact lenses (72% H2O-up take) were adapted and worn permanently. 2 patients had worn already for a long time usual HEMA-lenses. The lenses showed themselves to be favorable against mechanical irritation from cilia and accessory eyelashes and from scarring conjunctival conditions, and they affected favorably the signs of dessication of the cornea. Corneal defects healed, and the patients had subjectively no complaints. It is sometimes necessary to replace the tears. An increase in the corneal vascularisation already present could not be observed during the 18 months observation time.

  18. Cold atoms near superconductors: atomic spin coherence beyond the Johnson noise limit

    International Nuclear Information System (INIS)

    Kasch, B; Hattermann, H; Cano, D; Judd, T E; Zimmermann, C; Kleiner, R; Koelle, D; Fortagh, J; Scheel, S

    2010-01-01

    We report on the measurement of atomic spin coherence near the surface of a superconducting niobium wire. As compared to normal conducting metal surfaces, the atomic spin coherence is maintained for time periods beyond the Johnson noise limit. The result provides experimental evidence that magnetic near-field noise near the superconductor is strongly suppressed. Such long atomic spin coherence times near superconductors open the way towards the development of coherently coupled cold atom/solid state hybrid quantum systems with potential applications in quantum information processing and precision force sensing.

  19. Validation study by finite element method: the case of the Daniel Johnson Dam

    International Nuclear Information System (INIS)

    Lariviere, R.; Phat, T. M.; Poirier, C.; Thibeault, N.

    1997-01-01

    A structural study of the Daniel-Johnson multi-arch dam undertaken by Hydro-Quebec to determine the safest way of grouting the cracks at the base of some arches was described. A numerical model in the linear elastic domain was constructed. The model will be modified to incorporate other features such as the cracks at the base of arches, the cracks at the concrete-rock foundation contact area, and the restraining effect of downstream rock foundation. This paper highlights the quality assurance procedure related to model validation as recommended by the International Committee on Large Dams. 2 refs., 11 figs

  20. Dynamical symmetry breaking in the Jackiw-Johnson model and the gauge technique

    International Nuclear Information System (INIS)

    Singh, J.P.

    1984-01-01

    The Jackiw-Johnson model of dynamical gauge symmetry breaking has been re-examined in the light of the gauge technique. In the limit where the ratio of the axial to vector coupling constants becomes small, or, consistently, in the limit where the ratio of the axial-vector-boson mass to the fermion mass becomes small, an approximate solution for the fermion spectral function has been derived. This gives an extremely small ratio of the axial-vector-boson mass to the fermion mass. (author)

  1. Information theoretically secure, enhanced Johnson noise based key distribution over the smart grid with switched filters.

    Science.gov (United States)

    Gonzalez, Elias; Kish, Laszlo B; Balog, Robert S; Enjeti, Prasad

    2013-01-01

    We introduce a protocol with a reconfigurable filter system to create non-overlapping single loops in the smart power grid for the realization of the Kirchhoff-Law-Johnson-(like)-Noise secure key distribution system. The protocol is valid for one-dimensional radial networks (chain-like power line) which are typical of the electricity distribution network between the utility and the customer. The speed of the protocol (the number of steps needed) versus grid size is analyzed. When properly generalized, such a system has the potential to achieve unconditionally secure key distribution over the smart power grid of arbitrary geometrical dimensions.

  2. Guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis: An Indian perspective.

    Science.gov (United States)

    Gupta, Lalit Kumar; Martin, Abhay Mani; Agarwal, Nidheesh; D'Souza, Paschal; Das, Sudip; Kumar, Rajesh; Pande, Sushil; Das, Nilay Kanti; Kumaresan, Muthuvel; Kumar, Piyush; Garg, Anubhav; Singh, Saurabh

    2016-01-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous adverse drug reactions with a high morbidity and mortality that require immediate medical care. The various immunomodulatory treatments include systemic corticosteroids, cyclosporine, intravenous immunoglobulin, cyclophosphamide, plasmapheresis and tumor necrosis factor-α inhibitors. The ideal therapy of Stevens-Johnson syndrome/toxic epidermal necrolysis still remains a matter of debate as there are only a limited number of studies of good quality comparing the usefulness of different specific treatments. The aim of this article is to comprehensively review the published medical literature and frame management guidelines suitable in the Indian perspective. The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) assigned the task of preparing these guidelines to its special interest group on cutaneous adverse drug reactions. The group performed a comprehensive English language literature search for management options in Stevens-Johnson syndrome/toxic epidermal necrolysis across multiple databases (PubMed, EMBASE, MEDLINE and Cochrane) for keywords (alone and in combination) and MeSH items such as "guidelines," "Stevens-Johnson syndrome," "toxic epidermal necrolysis," "corticosteroids," "intravenous immunoglobulin," "cyclosporine" and "management." The available evidence was evaluated using the strength of recommendation taxonomy and graded using a three-point scale. A draft of clinical recommendations was developed on the best available evidence which was also scrutinized and critically evaluated by the IADVL Academy of Dermatology. Based on the inputs received, this final consensus statement was prepared. A total of 104 articles (meta-analyses, prospective and retrospective studies, reviews [including chapters in books], previous guidelines [including Indian guidelines of 2006] and case series) were critically evaluated and the evidence

  3. Mycoplasma pneumoniae-Induced-Stevens Johnson Syndrome: Rare Occurrence in an Adult Patient

    Directory of Open Access Journals (Sweden)

    Samad Rasul

    2012-01-01

    Full Text Available Stevens-Johnson syndrome (SJS is an uncommon occurrence in Mycoplasma pneumoniae (M. pneumoniae infection (1–5% and has been mainly reported in children and young adults. We present a case of SJS in a 32-year-old male induced by M. pneumoniae infection. This patient presented with fever, cough, and massive occupation of mucus membranes with swelling, erythema, and necrosis accompanied by a generalized cutaneous rash. He clinically responded after treatment with antibiotics and IVIG. SJS is usually a drug-induced condition; however, M. pneumoniae is the commonest infectious cause and should be considered in the differential diagnosis.

  4. Burn Center Care of Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

    Science.gov (United States)

    Cartotto, Robert

    2017-07-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, life-threatening, cutaneous drug reactions. Medications are the most common cause, although an infection may be responsible. A link between genetics and certain medications has been established. Clinical diagnosis should be confirmed with biopsy. When the area of epidermal detachment approaches 30%, burn center care is advisable. An ophthalmologist should be consulted to optimize ocular care. Pharmacologic interruption has been sought but there is little consensus on the most appropriate agent and no high-quality studies have been conducted to demonstrate if any of these agents lead to improved survival. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  5. Forest inventory: Peter T. Johnson Wildlife Mitigation Unit, Craig Mountain, Idaho. Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Narolski, Steven W.

    1996-12-01

    The primary objective of this report is to determine the quantity and quality of existing forest habitat types on the 59,991-acre Peter T. Johnson Wildlife Mitigation Unit (WMU). Products from this effort include a description of the ecological condition, a map of habitat types, and an inventory of forest resources on the WMU lands. The purpose of this and other resource inventories (plant and wildlife) is to assess the current resources condition of the WMU and to provide necessary information to generate a long-term management for this area.

  6. Forest inventory, Peter T. Johnson Wildlife Mitigation Unit, Craig Mountain, Idaho. Final report

    International Nuclear Information System (INIS)

    Narolski, S.W.

    1996-12-01

    The primary objective of this report is to determine the quantity and quality of existing forest habitat types on the 59,991-acre Peter T. Johnson Wildlife Mitigation Unit (WMU). Products from this effort include a description of the ecological condition, a map of habitat types, and an inventory of forest resources on the WMU lands. The purpose of this and other resource inventories (plant and wildlife) is to assess the current resources condition of the WMU and to provide necessary information to generate a long-term management for this area

  7. Johnson-Segalman -- Saint-Venant equations for viscoelastic shallow flows in the elastic limit

    OpenAIRE

    Boyaval, Sébastien

    2016-01-01

    The shallow-water equations of Saint-Venant, often used to model the long-wave dynamics of free-surface flows driven by inertia and hydrostatic pressure, can be generalized to account for the elongational rheology of non-Newtonian fluids too. We consider here the $4 \\times 4$ shallow-water equations generalized to viscoelastic fluids using the Johnson-Segalman model in the elastic limit (i.e. at infinitely-large Deborah number, when source terms vanish). The system of nonlinear first-order eq...

  8. Development of a long-life, high-reliability remotely operated Johnson noise thermometer

    International Nuclear Information System (INIS)

    Shepard, R.L.; Blalock, T.V.; Carroll, R.M.; Roberts, M.J.

    1991-01-01

    Space mission may require nuclear reactors to provide reliable electric power for habitats-platforms for extended periods of unattended operation. These reactors will be monitored and protected by measuring reactor coolant outlet temperature. To achieve performance goals of less than 1% temperature uncertainly at temperatures greater than 1300K for 10 years a Johnson noise thermometer is being developed that used a tuned circuit measuring system and allows dc resistance measurements to be made for continuous control of the reactor. In this paper the measurement system includes automatic signal validation features

  9. Collaboration can work--given the right commitment. Interview by Donald E.L. Johnson.

    Science.gov (United States)

    Preslar, L B

    1992-11-01

    Community health care networks require an unprecedented level of collaboration between hospitals and other providers. But how can hospitals that are steeped in a competitive mindset convert to a collaborative approach, especially if they have competed directly? In the following interview with Donald E.L. Johnson, editor and publisher of Health Care Strategic Management, Len B. Preslar Jr., president of The North Carolina Baptist Hospitals Inc., in Winston-Salem explains how to overcome impediments to collaboration. There is an increasing recognition by hospital leaders of the need to collaborate but a continuing underestimation of the time and energy needed to make it work.

  10. Left Activism, Succour and Selfhood

    DEFF Research Database (Denmark)

    Hughes, Celia Penelope

    2014-01-01

    an interchange of motherhood, domesticity, far-left politics, and close female friendship. The article will show how the women's epistolary friendship offers intimate insight into female self-fashioning at a breakthrough social and political moment in 1970s Britain. As they reflected on some of the key political...

  11. Left ventricular diastolic performance of left ventricular hypertrophy

    Energy Technology Data Exchange (ETDEWEB)

    Ikezono, Tohru; Ozaki, Masaharu; Yamagishi, Takashi; Shimizu, Tatsuro; Furutani, Yuji; Kusukawa, Reizo

    1987-02-01

    To study left ventricular diastolic performance in different forms of left ventricular hypertrophy, ECG gated cardiac blood pool scan was performed in 11 patients with hypertrophic nonobstructive cardiomyopathy (HCM) and in 19 patients with hypertension (HT), and left ventricular volume curve (LVVC) was analyzed and compared with those of 13 normal subjects (N). Ejection fraction (EF) and early filling volume ratio (the ratio of volume increment of 100 msec later than the zero point in the first derivative of LVVC to the end diastolic volume) (%EFV) were computed from LVVC. Peak ejection rate (PER) and peak filling rate (PFR) were obtained from the first derivative of LVVC. Peak ejection acceleration (PEA) and peak filling acceleration (PFA) were calculated from the second derivative of LVVC. EF, PER and PEA did not show any difference between these 3 groups. PFR was lower in HT (2.6 +- 0.5) compared with those in HCM (3.0 +- 0.5) (p < 0.05) and in N (3.4 +- 0.5) (p < 0.001), but the %EFV in HCM (4.9 +- 1.8) was lower than those in HT (6.9 +- 1.9) (p < 0.01) and in N (11.4 +- 1.4) (p < 0.001). Moreover, PFA in HCM (27.9 +- 7.2) was increased than those in HT (20.2 +- 5.4) (p < 0.01) with no differences between HCM and N (29.4 +- 8.1). Significant correlation was observed between PFR and PFA (Y = 0.06X + 1.4. r = 0.856. p < 0.001). These result indicate that, in HCM, reduced increase in early left ventricular volume is compensated by a greater filling acceleration. In contrast, there is no compensation by filling acceleration in HT.

  12. Conceptual Inadequacy of the Shore and Johnson Axioms for Wide Classes of Complex Systems

    Directory of Open Access Journals (Sweden)

    Constantino Tsallis

    2015-05-01

    Full Text Available It is by now well known that the Boltzmann-Gibbs-von Neumann-Shannon logarithmic entropic functional (\\(S_{BG}\\ is inadequate for wide classes of strongly correlated systems: see for instance the 2001 Brukner and Zeilinger's {\\it Conceptual inadequacy of the Shannon information in quantum measurements}, among many other systems exhibiting various forms of complexity. On the other hand, the Shannon and Khinchin axioms uniquely mandate the BG form \\(S_{BG}=-k\\sum_i p_i \\ln p_i\\; the Shore and Johnson axioms follow the same path. Many natural, artificial and social systems have been satisfactorily approached with nonadditive entropies such as the \\(S_q=k \\frac{1-\\sum_i p_i^q}{q-1}\\ one (\\(q \\in {\\cal R}; \\,S_1=S_{BG}\\, basis of nonextensive statistical mechanics. Consistently, the Shannon 1948 and Khinchine 1953 uniqueness theorems have already been generalized in the literature, by Santos 1997 and Abe 2000 respectively, in order to uniquely mandate \\(S_q\\. We argue here that the same remains to be done with the Shore and Johnson 1980 axioms. We arrive to this conclusion by analyzing specific classes of strongly correlated complex systems that await such generalization.

  13. Feasibility Study of Economics and Performance of Solar Photovoltaics at Johnson County Landfill

    Energy Technology Data Exchange (ETDEWEB)

    Salasovich, J.; Mosey, G.

    2012-01-01

    The U.S. Environmental Protection Agency (EPA), in accordance with the RE-Powering America's Land initiative, selected the Johnson County Landfill in Shawnee, Kansas, for a feasibility study of renewable energy production. Citizens of Shawnee, city planners, and site managers are interested in redevelopment uses for landfills in Kansas that are particularly well suited for grid-tied solar photovoltaic (PV) installation. This report assesses the Johnson County Landfill for possible grid-tied PV installations and estimates the cost, performance, and site impacts of three different PV options: crystalline silicon (fixed tilt), crystalline silicon (single-axis tracking), and thin film (fixed tilt). Each option represents a standalone system that can be sized to use an entire available site area. In addition, the report outlines financing options that could assist in the implementation of a system. The feasibility of PV systems installed on landfills is highly impacted by the available area for an array, solar resource, operating status, landfill cap status, distance to transmission lines, and distance to major roads. The report findings are applicable to other landfills in the surrounding area.

  14. DOES BRAND EXTENSION IMPACT PARENT BRAND: A CASE OF JOHNSON, UK

    Directory of Open Access Journals (Sweden)

    Muhammad Shakil AHMAD

    2011-01-01

    Full Text Available Purpose of study: The main purpose of this study is to check the impact ofbrand extensions on brand image. For this purpose Johnson is selected asparent brand for current research. The targeted brand extensions areJohnson shampoo, Johnson’s isotonic drinks, Johnson’s sports wear andJohnson’s suntan lotion. Research Methodology: sample was selected fromBradford, UK. Sample consists of graduate students including males as wellas female. Total sample size is 60 and data was collected through selfadministered questionnaires. For each brand 15 respondents were selected.Convenient sampling was selected as sampling technique. Results: Resultsshow that Johnson’s have high brand awareness and perceived quality.While there is negative correlation results for brand fit on brand image forthose product extensions which are not in same brand category i.e.Johnson’s sportswear and Johnson’s isotonic drinks. Conclusion: It isconcluded from study results that launching new product in same parentbrand category have high chance of success while in different category isrisk.

  15. NASA Pathways Co-op Tour Johnson Space Center Fall 2013

    Science.gov (United States)

    Masood, Amir; Osborne-Lee, Irwin W.

    2013-01-01

    This report outlines the tasks and objectives completed during a co-operative education tour with National Aeronautics and Space Association (NASA) at the Johnson Space Center in Houston, Texas. I worked for the Attitude & Pointing group of the Flight Dynamics Division within the Mission Operations Directorate at Johnson Space Center. NASA's primary mission is to support and expand the various ongoing space exploration programs and any research and development activities associated with it. My primary project required me to develop and a SharePoint web application for my group. My secondary objective was to become familiar with the role of my group which was primarily to provide spacecraft attitude and line of sight determination, including Tracking and Data Relay Satellite (TDRS) communications coverage for various NASA, International, and commercial partner spacecraft. My projects required me to become acquainted with different software systems, fundamentals of aerospace engineering, project management, and develop essential interpersonal communication skills. Overall, I accomplished multiple goals which included laying the foundations for an updated SharePoint which will allow for an organized platform to communicate and share data for group members and external partners. I also successfully learned about the operations of the Attitude & Pointing Group and how it contributes to the Missions Operations Directorate and NASA's Space Program as a whole

  16. Barriers to children having a medical home in Johnson County, Iowa: notes from the field.

    Science.gov (United States)

    Swingle, Hanes M; Wilmoth, Ralph; Aquilino, Mary L

    2008-09-01

    In Iowa 70.7% of children who qualify for Title XIX and/or Title V services have a medical home, but in Johnson County, Iowa only 54.0% of such children have one. Objectives Identify barriers to access to a medical home for children who use Johnson County Public Health (JCPH) services and recommend strategies to overcome these barriers. Families with children attending JCPH well-child and WIC clinics were randomly selected to be interviewed using a semi-structured, 38-item questionnaire. Data analysis used qualitative and quantitative methodologies. Among 71 families interviewed, 41 had children without a medical home and 85% of these families cited financial barriers. Lack of U.S. citizenship accounted for 59% without health insurance. A recent move contributed to 29% not having medical homes. Nine different languages were spoken among the 41 families without a medical home. Forty-one percent of all parents interviewed had never had a medical home themselves. Many parents perceived emergency departments as more convenient than doctors' offices. Lack of health insurance, due primarily to citizenship status, is the greatest barrier to access to a medical home in this population. The migratory nature of the U.S. population, marked cultural diversity, and parental attitudes were additional barriers to children's access to a medical home. Strategies to overcome these barriers are discussed.

  17. Complications of Stevens-Johnson syndrome beyond the eye and skin.

    Science.gov (United States)

    Saeed, Hajirah; Mantagos, Iason S; Chodosh, James

    2016-02-01

    Ocular and cutaneous disease are common chronic sequelae of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and have been well described in the literature. Long-term complications affecting other organ systems have not been so well described. The purpose of this review article is to highlight non-ocular and non-cutaneous chronic complications of SJS/TEN. The PubMed database was searched for the keywords "Stevens-Johnson syndrome" and "toxic epidermal necrolysis" through September 1, 2014. Relevant articles were then reviewed in full. 138 articles in the English language were found that described chronic sequelae of SJS/TEN. Our search revealed six affected organ systems other than the eyes and integument, with chronic sequelae from SJS/TEN: respiratory, gastrointestinal/hepatic, oral, otorhinolaryngologic, gynecologic/genitourinary, and renal. Complications involving these organs systems appeared likely to reduce the quality of life for SJS/TEN survivors. SJS/TEN is a multi-organ disease requiring multidisciplinary care from a variety of specialists. Affected patients have complex hospital stays, and their quality of life may be severely impacted by multiple long-term complications. We believe that preventative care in the acute setting might limit the development and progression of many of the sequelae described above. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

  18. Entry layout in the history of English lexicography: Bailey 1736, Martin 1749 and Johnson 1755

    Directory of Open Access Journals (Sweden)

    Ruxandra Vişan

    2010-01-01

    Full Text Available The present paper focuses on the history of lexicography and proposes a comparative analysis of three significant English dictionaries of the 18th century: Nathan Bailey’s Dictionarium Britannicum (second edition, 1736, Benjamin Martin’s Lingua Britannica Reformata (first edition, 1749, Samuel Johnson’s Dictionary of the English Language (first edition, 1755. The paper discusses the structure of the entries in these texts, concentrating on the changes undergone from Bailey to Johnson, and attempts to show that the increased complexity of Martin’s and Johnson’s lexicographic entries marks a departure from the model of the “universal” dictionary. While the structure of universal dictionaries such as Bailey’s retains important similarities with that of the encyclopaedias of the time, later 18th century dictionaries, such as those of Johnson, are closer in structure to contemporary dictionaries of the English language, indicating a more complete separation of what starts to count as “linguistic” from what starts to count as “encyclopaedic”.

  19. Tegafur/gimeracil/oteracil (TS-1 induced Stevens–Johnson syndrome: Case report

    Directory of Open Access Journals (Sweden)

    Satoko Minakawa

    2013-09-01

    Full Text Available TS-1 is an oral fluoropyrimidine anticancer drug that contains tegafur, gimeracil, and oteracil. A 78-year-old Japanese male who was diagnosed with carcinoma of the oral floor (rT4aN0M0 was prescribed a standard dose of TS-1 (80 mg/day. On Day 8 after administration of TS-1, an eruption developed. There was erythema, along with vesicles and erosions involving the lip, face, neck, trunk, limbs, and genitals. The drug-induced lymphocyte stimulation test (DLST for TS-1 was negative on the 23rd day, but positive on the 43rd day (20 days after discontinuing prednisolone. The condition was diagnosed as Stevens–Johnson syndrome due to TS-1 because of the clinical course and laboratory results. This case and 24 cases previously reported in the literature were analyzed. The types of drug eruption were drug-related lupus (9 cases, acral erythema (7 cases, scleroderma-like skin lesion (2 cases, Stevens–Johnson syndrome (2 cases, lichenoid eruption (1 case, purpura (1 case, lichen planus (1 case, erythema multiforme (1 case, hypopigmentation (1 case and toxic epidermal necrolysis (1 case, respectively. In view of the increasing usage of TS-1 in several common cancers, clinicians should be aware of drug eruptions due to TS-1.

  20. Are steroids effective in toxic epidermal necrolysis and Stevens-Johnson syndrome?

    Directory of Open Access Journals (Sweden)

    Rodrigo Meza

    2017-06-01

    Full Text Available Resumen La necrólisis epidérmica tóxica y el síndrome de Stevens-Johnson son reacciones cutáneas adversas graves a medicamentos e infecciones. Los corticoides se describen como una alternativa terapéutica, sin embargo, su uso es aún controvertido. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples bases de datos, identificamos cuatro revisiones sistemáticas que en conjunto incluyen once estudios primarios que responden la pregunta de interés. Extrajimos los datos y preparamos una tabla de resumen de los resultados utilizando el método GRADE. Concluimos que no está claro si los corticoides disminuyen la mortalidad o la estadía hospitalaria en la necrólisis epidérmica tóxica y el síndrome de Stevens-Johnson porque la certeza de la evidencia es muy baja.

  1. 75 FR 1449 - Qualification of Drivers; Exemption Applications; Diabetes

    Science.gov (United States)

    2010-01-11

    .... Huels, Daniel R. Jackson, Ricky D. Jameson, Michael A. Johnson, Justin D. Jones, Curtis W. Keelin, Jr..., Terry L. Riddell, Rodney R. Rupe, Darrell S. Seibold, Roger L. Summerfield, Daren D. White, and Jimmy P...

  2. 76 FR 69793 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-11-09

    ... Michael Wayne Gilley William C. Miller Darrell Prather James Jaramillo One applicant, Robert J. Moore, Jr... federal government, state, or any political sub-division of the state. Jimmy Dale Johnson, II Wesley R...

  3. Producing The New Regressive Left

    DEFF Research Database (Denmark)

    Crone, Christine

    This thesis is the first comprehensive research work conducted on the Beirut based TV station, an important representative of the post-2011 generation of Arab satellite news media. The launch of al-Mayadeen in June 2012 was closely linked to the political developments across the Arab world...... members, this thesis investigates a growing political trend and ideological discourse in the Arab world that I have called The New Regressive Left. On the premise that a media outlet can function as a forum for ideology production, the thesis argues that an analysis of this material can help to trace...... the contexture of The New Regressive Left. If the first part of the thesis lays out the theoretical approach and draws the contextual framework, through an exploration of the surrounding Arab media-and ideoscapes, the second part is an analytical investigation of the discourse that permeates the programmes aired...

  4. A Modified Johnson-Cook Model for Flow Behavior of Alloy 800H at Intermediate Strain Rates and High Temperatures

    Science.gov (United States)

    Shokry, Abdallah

    2017-12-01

    A modified Johnson-Cook model for the flow behavior of alloy 800H at intermediate strain rates and high temperatures is presented. The modification is based on a study of the relation between strain hardening and both strain rate and softening parameters. The predicted stresses obtained using the modified model are compared to those obtained using the original Johnson-Cook model. The parameters constitute the two models are determined using the inverse method, Kalman filter. The results show that the modified model fits the experimental data very well for different combinations of strain rates and temperatures, with a mean value of R-squared regression of 0.90 for the modified model and 0.74 for the original Johnson-Cook model.

  5. Elfin butterflies of the genus Rhamma Johnson (Lepidoptera: Lycaenidae: Theclinae): A review of the Colombian species.

    Science.gov (United States)

    Prieto, Carlos; Vargas, Maria A

    2016-03-22

    The Colombian species of the genus Rhamma Johnson, 1992 are revised. Male and female phenotypes of all species are associated and diagnosed, and data on their distributions are given along with a discussion of the geographic variability of the species. Thirteen taxa are considered valid at the species level. The following taxonomic changes are proposed: Rhamma andradei (Le Crom & Johnson), stat. nov, comb. nov.; previously considered a nomen dubium in Penaincisalia Johnson, the taxon is considered a valid species of Rhamma. The placement of Rhamma anosma (Draudt), comb. nov., described as Thecla, is confirmed as belonging to Rhamma. A lectotype is designated for Thecla mishma Hewitson, 1878. Adults, male and female genitalia, and distribution maps are depicted for all species, along with an identification key based on adults.

  6. Systolic left ventricular function according to left ventricular concentricity and dilatation in hypertensive patients

    DEFF Research Database (Denmark)

    Bang, Casper; Gerdts, Eva; Aurigemma, Gerard P

    2013-01-01

    Left ventricular hypertrophy [LVH, high left ventricular mass (LVM)] is traditionally classified as concentric or eccentric based on left ventricular relative wall thickness. We evaluated left ventricular systolic function in a new four-group LVH classification based on left ventricular dilatation...

  7. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Analysis of Triggers and Implications for Improving Prevention.

    Science.gov (United States)

    Miliszewski, Monica A; Kirchhof, Mark G; Sikora, Sheena; Papp, Anthony; Dutz, Jan P

    2016-11-01

    Stevens-Johnson syndrome and toxic epidermal necrolysis are severe mucocutaneous adverse drug reactions characterized by extensive epidermal detachment. The mortality rates have been reported to vary between 1% and 5% for Stevens-Johnson syndrome and 25% and 35% for patients with toxic epidermal necrolysis. Studies have shown that early recognition and prompt withdrawal of the causative agent leads to increased patient survival. A retrospective chart review was conducted on 64 patients admitted to Vancouver General Hospital with a diagnosis of Stevens-Johnson syndrome or toxic epidermal necrolysis from 2001 to 2011. The aim of this study was to identify the medications most often implicated in triggering Stevens-Johnson syndrome and toxic epidermal necrolysis, as well as to delineate the timeline of identification and removal of these triggers. A trigger was identified in 75% of cases. Allopurinol was the single most common offending agent (20% of cases). Anticonvulsants and antibiotics were common triggers. The offending agent was often removed at time of hospital admission/diagnosis but not at onset of symptoms. A history of prior culprit drug exposure with previous mucocutaneous adverse reaction was noted in 19% of cases with identified triggers. Asians and Native North Americans had a higher mortality than whites, and Asians more frequently had allopurinol as a trigger. The onset and high mortality rate of Stevens-Johnson syndrome/toxic epidermal necrolysis may be related to unawareness of the early signs and symptoms of Stevens-Johnson syndrome and toxic epidermal necrolysis, the common drug triggers that cause it, and what investigations (human leukocyte antigen typing in Asians) can be done to prevent it. Copyright © 2016. Published by Elsevier Inc.

  8. Does Johnson's Prescriptive Approach Still Have a Role to Play in Modern-Day Dictionaries?

    Directory of Open Access Journals (Sweden)

    Rufus H. Gouws

    2011-10-01

    Full Text Available

    ABSTRACT: Samuel Johnson's dictionary (1755 confirmed both the status of dictionaries as authoritative sources of (linguistic knowledge and the prescriptive approach in lexicography. This approach prevailed for a long time. During the last decades the descriptive approach came to the fore, aptly supported by the increased reliance on lexicographic corpora. Modern-day lexicography has also witnessed the introduction of a third approach, i.e. the proscriptive approach, which includes features of both the prescriptive and the descriptive approach. This article investigates the occurrence of the prescriptive, descriptive and proscriptive approaches in modern-day dictionaries. A distinction is made between dictionaries focusing on language for general purposes and dictionaries focusing on languages for special purposes. It is shown that users rely on dictionaries as prescriptive reference sources and expect lexicographers to provide them with an answer to the specific question that prompted the dictionary consultation process. It is argued that knowledgeable dictionary users must be able to achieve an unambiguous retrieval of information and must be able to rely on the dictionary to satisfy their specific cognitive or communicative needs. Here the proscriptive approach plays an important role.

    OPSOMMING: Het Johnson se preskriptiewe benadering nog 'n rol te speel in moderne woordeboeke? Samuel Johnson se woordeboek (1755 het die status van woordeboeke as gesaghebbende houers van (taalkundige kennis, maar eweneens die preskriptiewe benadering in leksikografie gevestig. Hierdie benadering het lank gegeld. Gedurende die onlangse dekades het die deskriptiewe benadering op die voorgrond getree, sterk ondersteun deur toenemende benutting van korpora. Moderne leksikografie het 'n derde benadering beleef, te wete die proskriptiewe benadering wat kenmerke van sowel die preskriptiewe as die deskriptiewe benadering bevat. Hierdie artikel ondersoek die

  9. Hydrogeology and simulation of ground-water flow in the Silurian-Devonian aquifer system, Johnson County, Iowa

    Science.gov (United States)

    Tucci, Patrick; McKay, Robert M.

    2006-01-01

    Bedrock of Silurian and Devonian age (termed the “Silurian-Devonian aquifer system”) is the primary source of ground water for Johnson County in east-central Iowa. Population growth within municipal and suburban areas of the county has resulted in increased amounts of water withdrawn from this aquifer and water-level declines in some areas. A 3-year study of the hydrogeology of the Silurian-Devonian aquifer system in Johnson County was undertaken to provide a quantitative assessment of ground water resources and to construct a ground-water flow model that can be used by local governmental agencies as a management tool.

  10. STEVENS-JOHNSON SYNDROME — TOXIC EPIDERMAL NECTROLYSIS IN CHILDREN. PART I. DETERMINATION, ETIOLOGY, PATHOGENESIS, CLINICAL MANIFESTATIONS, SYSTEMIC TREATMENT

    Directory of Open Access Journals (Sweden)

    V.F. Zhernosek

    2011-01-01

    Full Text Available Part I of the literature review provides modern terminology and classification of Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN, which is now considered different ways of treating the single pathological process induced in children by infections, drugs, malignant and autoimmune diseases. It illustrates in detail the latest data on pathogenesis, describes clinical manifestations of both scenarios and their transition forms. Special emphasis is made on the organisation of care for patients with SJS and TEN. It details various aspects of systemic therapy.Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, systemic treatment, children.

  11. Rust Contamination from Water Leaks in the Cosmic Dust Lab and Lunar and Meteorite Thin Sections Labs at Johnson Space Center

    Science.gov (United States)

    Kent, J. J.; Berger, E. L.; Fries, M. D.; Bastien, R.; McCubbin, F. M.; Pace, L.; Righter, K.; Sutter, B.; Zeigler, R. A.; Zolensky, M.

    2017-01-01

    On the early morning of September 15th, 2016, on the first floor of Building 31 at NASA-Johnson Space Center, the hose from a water chiller ruptured and began spraying water onto the floor. The water had been circulating though old metal pipes, and the leaked water contained rust-colored particulates. The water flooded much of the western wing of the building's ground floor before the leak was stopped, and it left behind a residue of rust across the floor, most notably in the Apollo and Meteorite Thin Section Labs and Sample Preparation Lab. No samples were damaged in the event, and the affected facilities are in the process of remediation. At the beginning of 2016, a separate leak occurred in the Cosmic Dust Lab, located in the same building. In that lab, a water leak occurred at the bottom of the sink used to clean the lab's tools and containers with ultra-pure water. Over years of use, the ultra-pure water eroded the metal sink piping and leaked water onto the inside of the lab's flow bench. This water also left behind a film of rusty material. The material was cleaned up and the metal piping was replaced with PVC pipe and sealed with Teflon plumber's tape. Samples of the rust detritus were collected from both incidents. These samples were imaged and analyzed to determine their chemical and mineralogical compositions. The purpose of these analyses is to document the nature of the detritus for future reference in the unlikely event that these materials occur as contaminants in the Cosmic Dust samples or Apollo or Meteorite thin sections.

  12. Rebuilding the US Health Left

    Directory of Open Access Journals (Sweden)

    Victor W. Sidel, MD

    2010-02-01

    Full Text Available With this issue Social Medicine begins a series of invited papers on the topic: “Rebuilding the US Health Left.” In this editorial we will outline our vision for this series. We undertake this project aware that our good friend and mentor, Dr. Walter Lear, one of the leading health activists of the 20th century, lies critically ill. Walter was the creator and custodian of the US Health Left Archives, a collection that is now with the University of Pennsylvania library. The collection reminds us of the important role left health care workers played in US history throughout the 20th century. They advocated for a national health program (Committee on the Costs of Medical Care, Physicians Forum, Medical Care Section/APHA, HealthPAC, Physicians for a National Health Program, National Physicians Alliance, provided international solidarity (American Soviet Medical Society, international brigades during the Spanish Civil War, Central American Solidarity Movement, Committee to Help Chilean Health Workers, Doctors for Global Health, traced the connections between disease and social class (Sigerist Circle, Spirit of 1848, APHA, fought for workers’ health (Councils for Occupational Safety and Health; Occupational Health and Safety Section, APHA participated in anti-war movements (Medical Committee for Human Rights, Physicians for Social Responsibility, International Physicians for the Prevention of Nuclear War, created new models of health care delivery (Health Cooperatives, Prepaid Health Maintenance Organizations, Community Health Centers, National Health Service Corps, Free Clinics, were central to the struggle for women’s rights (Planned Parenthood, Physicians for Reproductive Choice and Health, supported the civil rights movement both in medicine and in the broader society (National Medical Association, Medical Committee for Human Rights, played key roles in the movement for gay rights (ACT-UP, Gay & Lesbian Medical Association, Lesbian, Gay

  13. Exploring a Model of Symbolic Social Communication: The Case of ‘Magic’ Johnson

    Science.gov (United States)

    FLORA, JUNE A.; SCHOOLER, CAROLINE; MAYS, VICKIE M.; COCHRAN, SUSAN D.

    2009-01-01

    We propose a model of symbolic social communication to explain the process whereby sociocultural identity mediates relationships among receivers, sources and messages to shape message effects. This exploratory study examines how two at-risk groups of African American men responded to various HIV prevention messages delivered by celebrity and professional sources. We interviewed 47 men from a homeless shelter and 50 male college students. Members of both groups were likely to select Johnson as the best person to deliver HIV prevention messages among a list of African American celebrity and professional sources. Results suggest the symbolic meanings embedded in celebrities and message topics are important and enduring influences on message effects. The images and ideas that a source represents are transferred to the advocated behavior, attitude or knowledge change and thus shape how messages are interpreted and received. Further understanding of how culture influences the effects of persuasive messages is critical for the improvement of health-communication campaigns. PMID:22011997

  14. Johnson-Cook Strength Model Constants for VascoMax 300 and 1080 Steels

    International Nuclear Information System (INIS)

    Cinnamon, J. D.; Palazotto, A. N.; Kennan, Z.; Brar, N. S.; Bajaj, D.

    2006-01-01

    High strength steels, VascoMax 300 and 1080, are characterized under tension at strain rates of ∼1/s, ∼500/s, ∼1000/s, and ∼1500/s and at high temperatures using the quasi-static and split Hopkinson bar techniques. The data on 1080 steel exhibited a typical strain hardening response, whereas Vasco-Max 300 steel showed diminishing flow stress beyond yielding because of localized necking in gauge section of the tested specimens. The tension data are analyzed to determine the Johnson-Cook (J-C) strength model constants for the two steels. The flow stress values for VascoMax are adjusted to account for necking, and the corrected J-C model is developed

  15. Stevens-Johnson syndrome in patients on phenytoin and cranial radiotherapy

    International Nuclear Information System (INIS)

    Khafaga, Y.M.; Jamshed, A.; Allam, A.A.K.; Ezzat, A.; Gray, A.J.; Schultz, H.; Mourad, W.A.; Al Eisa, A.

    1999-01-01

    The use of phenytoin as a prophylactic anticonvulsant after brain surgery, particularly for brain tumors, is a common practice, regardless of whether the patient has a previous history of convulsions. This treatment policy assumes that the benefits exceed the risks. Four cases are described of adverse reactions of phenytoin during the cocomitant use of cranial radiotherapy. In one patient this proved fatal. There is increasing anecdotal support in the literature for a synergistic effect between phenytoin therapy and cranial radiotherapy that can result in the life-threatening Stevens-Johnson syndrome. While the association is uncommon, four cases within 24 months in one department suggest that the routine use of postoperative phenytoin as a prophylactic anticonvulsant in the absence of a history of seizures may not be warranted, particularly if the patient is to receive cranial radiotherapy. (orig.)

  16. Is intravenous immunoglobulin effective in toxic epidermal necrolysis and Stevens-Johnson syndrome?

    Directory of Open Access Journals (Sweden)

    Lucas Navajas

    2014-10-01

    Full Text Available Toxic epidermal necrolysis and Stevens-Johnson syndrome are severe cutaneous adverse drug reactions. Intravenous immunoglobulin is described as a therapeutic option, however its use is still controversial. Using Epistemonikos database, which is maintained by screening over 20 databases, we identified six systematic reviews, including 39 primary studies. We combined the evidence using tables for summary of findings, following the GRADE approach, and concluded there is uncertainty about the effects of intravenous immunoglobulin because the certainty of the evidence is very low; it probably leads to important adverse effects; and has high cost. Intravenous immunoglobulin should not be used outside the context of a clinical trial, or only in cases where other treatments have failed and there are no resource constraints.

  17. Peristaltic motion of a Johnson-Segalman fluid in a planar channel

    Directory of Open Access Journals (Sweden)

    Hayat T.

    2003-01-01

    Full Text Available This paper is devoted to the study of the two-dimensional flow of a Johnson-Segalman fluid in a planar channel having walls that are transversely displaced by an infinite, harmonic travelling wave of large wavelength. Both analytical and numerical solutions are presented. The analysis for the analytical solution is carried out for small Weissenberg numbers. (A Weissenberg number is the ratio of the relaxation time of the fluid to a characteristic time associated with the flow. Analytical solutions have been obtained for the stream function from which the relations of the velocity and the longitudinal pressure gradient have been derived. The expression of the pressure rise over a wavelength has also been determined. Numerical computations are performed and compared to the perturbation analysis. Several limiting situations with their implications can be examined from the presented analysis.

  18. Stevens-Johnson Syndrome and Corneal Ectasia: Management and a Case for Association.

    Science.gov (United States)

    Saeed, Hajirah N; Kohanim, Sahar; Le, Hong-Gam; Chodosh, James; Jacobs, Deborah S

    2016-09-01

    To report the occurrence of corneal ectasia (ECT) in patients with history of Stevens-Johnson syndrome (SJS), and to make the case for an association between these 2 diagnoses. We also report the impact of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment on visual acuity (VA) in these patients. Retrospective cohort study. A manufacturing database of PROSE patients from 2002 to 2014 at Boston Foundation for Sight (BFS), a single-center clinical practice, was reviewed to identify patients with diagnoses of both SJS and ECT. Nine patients were identified with diagnoses of both SJS and ECT. In each case, review of the medical record revealed that diagnosis of SJS preceded that of ECT. The prevalence of ECT in this population exceeded that in the general population (P corneal microtrauma and matrix metalloproteinases. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  19. Delayed Stevens-Johnson Syndrome Secondary to the Use of Lamotrigine in Bipolar Mood Disorder.

    Science.gov (United States)

    Jha, Kunal Kishor; Chaudhary, Durgesh Prasad; Rijal, Tshristi; Dahal, Semanta

    2017-01-01

    Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. SJS is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. Standard trigger is drugs including anticonvulsants, antibiotics, and Mycoplasma pneumoniae infection. We report a case where a patient developed SJS secondary to delayed-type hypersensitivity reaction after 6 months of the use of lamotrigine, while his initial response during the first 6 months did not show any sign of SJS.

  20. A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption.

    Science.gov (United States)

    Maggini, Valentina; Lombardi, Niccolò; Lenti, Maria Carmela; Masi, Stefano; Trapani, Sandra; Pugi, Alessandra; Mugelli, Alessandro; Vannacci, Alfredo

    2015-07-01

    We describe a case of Steven-Johnson Syndrome (SJS) associated with albuterol exposure in a 6-year-old male. A possible contributing role of albuterol in SJS occurrence in the present case is strongly suggested by the temporal relationship between the event and the initiation of drug therapy as well as by the positive rechallenge. To the best of our knowledge, albuterol had not been previously associated with SJS in medical literature. It can be therefore possible that physicians, pediatricians in particular, probably not aware of the possible risk of albuterol-induced SJS, might underestimate skin reactions in children taking the drug, thus underreporting this kind of severe adverse drug reaction. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence.

    Science.gov (United States)

    Sharma, Bhawna; Sannegowda, Raghavendra Bakki; Gandhi, Pankaj; Dubey, Parul; Panagariya, Ashok

    2013-06-11

    Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine (CBZ) has been commonly implicated in SJS. Neuroleptic malignant syndrome (NMS) is a rare, life-threatening but potentially treatable condition. Among the neuroleptics, haloperidol (parenteral) is implicated as a most common drug for NMS. Though rare, association of NMS with CBZ and association of NMS with toxic epidermal necrolysis (TEN) in a single patient after administration of neuroleptics has been reported in the literature before. However, a combination of NMS and SJS in a single patient after administration of CBZ has not been reported so far. We present a patient with seizure who developed SJS and NMS following administration of CBZ.

  2. Trimethoprim-sulfamethoxazole-induced Steven Johnson syndrome in an HIV-infected patient.

    Science.gov (United States)

    Taqi, Syed Ahmed; Zaki, Syed Ahmed; Nilofer, Angadi Rajasab; Sami, Lateef Begum

    2012-01-01

    Trimethoprim-sulfamethoxazole (TMP/SMX) is a widely prescribed antimicrobial for the management of several uncomplicated infections. It is commonly used for the treatment and prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in the HIV-infected population. The adverse reaction to TMP/SMX is more frequent and severe in HIV-infected patients as compared to the general population. Here, we report a case of Stevens-Johnson syndrome (SJS) secondary to TMP/SMX. The patient had a generalized cutaneous reaction with involvement of the eyes, oral cavity, and genitals. He had elevated hepatic alanine aminotransferase and aspartate aminotransferase enzyme. TMP/SMX therapy was stopped and supportive treatment was started. His condition improved after eight days of stopping TMP/SMX therapy.

  3. Toxic epidermal necrolysis and Steven Johnson syndrome: 11-years experience and outcome.

    Science.gov (United States)

    Gravante, G; Delogu, D; Marianetti, M; Trombetta, M; Esposito, G; Montone, A

    2007-01-01

    Toxic epidermal necrolysis and Steven Johnson syndrome are rare diseases that usually follow drug-exposures. The authors present one retrospective study with their management and focus their retrospective analysis on finding prognostic factors. We reviewed charts of admitted patients from January 1995 to December 2005. Only those with an histologic-proved diagnosis were included in the study. Causative drugs, symptoms, management and outcome were recorded and analysed. We found 32 patients that met inclusion criteria. Mortality rate was 34.4% (11/32). Age, delay of referral, Total Burn Surface Area, white blood cells, creatinine, blood sodium, immunoglobulins therapy and more than two different types of blood bacterial species isolated were significantly correlated with death (p < 0.05). These data confirm prognostic factors already present in literature and find that the number of different bacterial species isolated from blood increase mortality. Further prospective studies are necessary to confirm these findings.

  4. Bronchiolitis obliterans complicating a pneumothorax after Stevens-Johnson syndrome induced by lamotrigine

    Directory of Open Access Journals (Sweden)

    Wu-ping Wang

    2015-03-01

    Full Text Available Bronchiolitis obliterans (BO was defined as a nonreversible obstructive lung disease in which the bronchioles are always compressed and narrowed by fibrosis or inflammation. In the severe event of lung collapse after BO, surgical intervention is often recommended, and conservative therapy is thought to be ineffective. Here, we report the case of a 9-year old girl clinically diagnosed as having bronchiolitis obliterans with abrupt occlusion of the right B4b bronchus. After a lamotrigine-induced Stevens-Johnson syndrome (SJS occurred, she presented with total collapse of the right lung on admission, which was subsequently complicated by a pneumothorax during conservative treatment, but with the re-expansion of the right upper lobe after intervention. The case indicates the possibility of reversing pulmonary atelectasis in BO. Thus, surgery may not be necessary.

  5. Signaling with the Eyebrows – Commentary on Huron, Dahl, and Johnson

    Directory of Open Access Journals (Sweden)

    John Ohala

    2009-11-01

    Full Text Available Huron, Dahl, and Johnson, in their paper “Facial Expression and Vocal Pitch Height: Evidence of an Intermodal Association”, demonstrated a positive correlation between the pitch of a sung note and the vertical position of the singer’s eyebrows. Moreover, other subjects viewing photographs of the faces of the singers, with the lower part of the face and neck of the singers blocked out, could accurately judge whether a high note or low note had been sung. The authors offer a number of hypothetical explanations for their findings. I propose a speculative, ethologically-based, explanation for these correlations: namely, how both pitch of voice and eyebrow position would be correlated in this way to convey to the viewer the degree of potential threat – or lack of threat – posed by the signaler.

  6. Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report

    Science.gov (United States)

    Kodliwadmath, Ashwin

    2017-01-01

    Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and mortality. Here, we describe the case of a 43-year-old male who developed SJS and myocarditis secondary to phenytoin. In spite of aggressive resuscitative efforts, the patient could not be revived. Thus, a combination of myocarditis with SJS increases the mortality and should be considered in patients with SJS secondary to phenytoin and associated shock. PMID:28744164

  7. Antiepileptic Drugs-induced Stevens–Johnson syndrome: A case Series

    Science.gov (United States)

    Trivedi, Bhavi S.; Darji, Nishita H.; Malhotra, Supriya D.; Patel, Pankaj R.

    2016-01-01

    Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin. To manage the reaction, the clinician withdrew the drug in all 8 cases, and in 1 case, the patient was shifted to valproate and symptomatic treatment was provided. There is still a controversy whether or not all AEDs can cause SJS. Recent studies have investigated the role of genetic factors - HLAB*502 allele in the development of AED-induced SJS in patients of Asian ancestry. PMID:28104975

  8. Antiepileptic Drugs-induced Stevens-Johnson syndrome: A case Series.

    Science.gov (United States)

    Trivedi, Bhavi S; Darji, Nishita H; Malhotra, Supriya D; Patel, Pankaj R

    2016-12-01

    Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin. To manage the reaction, the clinician withdrew the drug in all 8 cases, and in 1 case, the patient was shifted to valproate and symptomatic treatment was provided. There is still a controversy whether or not all AEDs can cause SJS. Recent studies have investigated the role of genetic factors - HLAB*502 allele in the development of AED-induced SJS in patients of Asian ancestry.

  9. Phenytoin-induced Stevens-Johnson syndrome with myocarditis: a rare case report.

    Science.gov (United States)

    Kodliwadmath, Ashwin

    2017-01-01

    Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and mortality. Here, we describe the case of a 43-year-old male who developed SJS and myocarditis secondary to phenytoin. In spite of aggressive resuscitative efforts, the patient could not be revived. Thus, a combination of myocarditis with SJS increases the mortality and should be considered in patients with SJS secondary to phenytoin and associated shock.

  10. Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

    Science.gov (United States)

    Yang, Che-Wen; Cho, Yung-Tsu; Chen, Kai-Lung; Chen, Yi-Chun; Song, Hsiang-Lin; Chu, Chia-Yu

    2016-05-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on long-term sequelae in patients admitted for SJS, SJS/TEN overlap, or TEN between 1998 and 2012. Among all 102 patients eligible for analysis, the 2 most common sequelae were cutaneous and ocular problems, both with incidences of 44.1%. Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient.

  11. Amoxycillin and clavulanic acid induced Stevens-Johnson syndrome: A case report.

    Science.gov (United States)

    Zaidi, Maheen; Zaidi, Syeda Kashaf; Bhutto, Moomal; Umer, Mohammad Yasir

    2017-01-01

    Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. In this case report, a 32 year old female reported chief complaint of itch skin eruptions all over the body along with erosive lesions on tongue, lips, buccal mucosa and genital mucosa. The reaction occurred after administration of augmentin (containing amoxycillin and clavulanic acid). She was treated with antimicrobials, antiallergics and conservative management. The patient improved and was discharged from the hospital. Causality assessment using Naranjo Adverse Drug Reaction Probability Scale revealed that amoxycillin and clavulanic acid combination was a possible cause for the adverse reaction with a score of 4.

  12. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Treatment With a Biologic: A Case Report

    Science.gov (United States)

    Chong, Ian; Chao, Alice

    2017-01-01

    Introduction One of the most dangerous dermatologic emergencies is Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN). Although a rare disease, it can often lead to significant mortality. Case Presentation In this case report, we present a 77-year-old man who developed a sloughing rash that was secondary to a nonsteroidal anti-inflammatory drug. In addition to the recommended supportive care, the patient was treated with etanercept, a new, less commonly used intervention. Discussion We provide a brief review of SJS/TEN. Nonsteroidal anti-inflammatory drugs are a rare cause of SJS/TEN, and additionally, the use of biologics is a novel treatment modality for SJS/TEN. PMID:28488978

  13. Stevens-Johnson syndrome in patients on phenytoin and cranial radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Khafaga, Y.M.; Jamshed, A.; Allam, A.A.K.; Ezzat, A.; Gray, A.J.; Schultz, H. [King Faisal Specialist Hospital and Research Centre, Riyadh (Saudi Arabia). Dept. of Oncology; Mourad, W.A. [King Faisal Specialist Hospital and Research Centre, Riyadh (Saudi Arabia). Dept. of Pathology; Al Eisa, A. [King Faisal Specialist Hospital and Research Centre, Riyadh (Saudi Arabia). Dept. of Medicine

    1999-05-01

    The use of phenytoin as a prophylactic anticonvulsant after brain surgery, particularly for brain tumors, is a common practice, regardless of whether the patient has a previous history of convulsions. This treatment policy assumes that the benefits exceed the risks. Four cases are described of adverse reactions of phenytoin during the cocomitant use of cranial radiotherapy. In one patient this proved fatal. There is increasing anecdotal support in the literature for a synergistic effect between phenytoin therapy and cranial radiotherapy that can result in the life-threatening Stevens-Johnson syndrome. While the association is uncommon, four cases within 24 months in one department suggest that the routine use of postoperative phenytoin as a prophylactic anticonvulsant in the absence of a history of seizures may not be warranted, particularly if the patient is to receive cranial radiotherapy. (orig.)

  14. Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin

    Energy Technology Data Exchange (ETDEWEB)

    Delattre, J.Y.; Safai, B.; Posner, J.B.

    1988-02-01

    In 15 months we encountered eight patients with intracranial tumors who developed erythema multiforme (EM) or erythema multiforme bullosa (Stevens-Johnson syndrome). All occurred shortly after use of phenytoin (DPH) and brain radiation therapy (WBRT). The clinical picture differed from the classic form of EM in that the erythema began on the scalp and spread to the extremities, progressing in three cases to extensive bullous formation. There were no cases of EM among patients who received either DPH or radiotherapy alone. The combination of DPH, WBRT, and tapering of steroids seems to predispose to EM. The pathogenesis of the disorder is probably immunologic. In the absence of seizures, anticonvulsants should not be given routinely to patients with brain tumors. When anticonvulsants are necessary in patients scheduled for WBRT, DPH may not be the drug of choice.

  15. Burn unit care of Stevens Johnson syndrome/toxic epidermal necrolysis: A survey.

    Science.gov (United States)

    Le, Hong-Gam; Saeed, Hajirah; Mantagos, Iason S; Mitchell, Caroline M; Goverman, Jeremy; Chodosh, James

    2016-06-01

    Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a systemic disease that can be associated with debilitating acute and chronic complications across multiple organ systems. As patients with acute SJS/TEN are often treated in a burn intensive care unit (BICU), we surveyed burn centers across the United States to determine their approach to the care of these patients. The goal of our study was to identify best practices and possible variations in the care of patients with acute SJS/TEN. We demonstrate that the method of diagnosis, use of systemic therapies, and involvement of subspecialists varied significantly between burn centers. Beyond supportive care provided to every patient, our data highlights a lack of standardization in the acute care of patients with SJS/TEN. A comprehensive guideline for the care of patients with acute SJS/TEN is indicated. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

  16. Environmental Physiology at the Johnson Space Center: Past, Present, and Future

    Science.gov (United States)

    Conkin, Johnny

    2007-01-01

    This viewgraph presentation reviews the work in environmental physiology done at Johnson Space Center (JSC). The work is aimed at keeping astronauts healthy. This is a different approach than treating the sick, and is more of an occupational health model. The reduction of risks is the main emphasis for this work. They emphasis is to reduce the risk of decompression sickness (DCS) and acute mountain sickness (AMS). The work in environmental physiology encompasses the following areas: (1) Pressure: hypobaric and hyperbaric (2) Gases: hypoxia and hyperoxia, hypercapnia--closed space issues, inert gas physiology / respiration (3) Temperature: hypothermia and hyperthermia, thermal comfort, Protective clothing diving, aviation, mountaineering, and space (4) Acceleration (5) Noise and Vibration (6) Exercise / Performance (6) Acclimatization / Adaptation: engineering solutions when necessary. This presentation reviews the work done at JSC in the areas of DCS and AMS.

  17. Bronchiolitis obliterans complicating a pneumothorax after Stevens-Johnson syndrome induced by lamotrigine.

    Science.gov (United States)

    Wang, Wu-ping; Ni, Yun-feng; Wei, Yao-ning; Li, Xiao-fei; Cheng, Qing-shu; Lu, Qiang

    2015-03-01

    Bronchiolitis obliterans (BO) was defined as a nonreversible obstructive lung disease in which the bronchioles are always compressed and narrowed by fibrosis or inflammation. In the severe event of lung collapse after BO, surgical intervention is often recommended, and conservative therapy is thought to be ineffective. Here, we report the case of a 9-year old girl clinically diagnosed as having bronchiolitis obliterans with abrupt occlusion of the right B4b bronchus. After a lamotrigine-induced Stevens-Johnson syndrome (SJS) occurred, she presented with total collapse of the right lung on admission, which was subsequently complicated by a pneumothorax during conservative treatment, but with the re-expansion of the right upper lobe after intervention. The case indicates the possibility of reversing pulmonary atelectasis in BO. Thus, surgery may not be necessary. Copyright © 2012. Published by Elsevier B.V.

  18. Modified Johnson-Cook model incorporated with electroplasticity for uniaxial tension under a pulsed electric current

    Science.gov (United States)

    Kim, Moon-Jo; Jeong, Hye-Jin; Park, Ju-Won; Hong, Sung-Tae; Han, Heung Nam

    2018-01-01

    An empirical expression describing the electroplastic deformation behavior is suggested based on the Johnson-Cook (JC) model by adding several functions to consider both thermal and athermal electric current effects. Tensile deformation behaviors are carried out for an AZ31 magnesium alloy and an Al-Mg-Si alloy under pulsed electric current at various current densities with a fixed duration of electric current. To describe the flow curves under electric current, a modified JC model is proposed to take the electric current effect into account. Phenomenological descriptions of the adopted parameters in the equation are made. The modified JC model suggested in the present study is capable of describing the tensile deformation behaviors under pulsed electric current reasonably well.

  19. CALIBRATING THE JOHNSON-HOLMQUIST CERAMIC MODEL FOR SIC USING CTH

    International Nuclear Information System (INIS)

    Cazamias, J. U.; Bilyk, S. R.

    2009-01-01

    The Johnson-Holmquist ceramic material model has been calibrated and successfully applied to numerically simulate ballistic events using the Lagrangian code EPIC. While the majority of the constants are ''physics'' based, two of the constants for the failed material response are calibrated using ballistic experiments conducted on a confined cylindrical ceramic target. The maximum strength of the failed ceramic is calibrated by matching the penetration velocity. The second refers to the equivalent plastic strain at failure under constant pressure and is calibrated using the dwell time. Use of these two constants in the CTH Eulerian hydrocode does not predict the ballistic response. This difference may be due to the phenomenological nature of the model and the different numerical schemes used by the codes. This paper determines the aforementioned material constants for SiC suitable for simulating ballistic events using CTH.

  20. Seismic reflection constraints on the glacial dynamics of Johnsons Glacier, Antarctica

    Science.gov (United States)

    Benjumea, Beatriz; Teixidó, Teresa

    2001-01-01

    During two Antarctic summers (1996-1997 and 1997-1998), five seismic refraction and two reflection profiles were acquired on the Johnsons Glacier (Livingston Island, Antarctica) in order to obtain information about the structure of the ice, characteristics of the ice-bed contact and basement topography. An innovative technique has been used for the acquisition of reflection data to optimise the field survey schedule. Different shallow seismic sources were used during each field season: Seismic Impulse Source System (SISSY) for the first field survey and low-energy explosives (pyrotechnic noisemakers) during the second one. A comparison between these two shallow seismic sources has been performed, showing that the use of the explosives is a better seismic source in this ice environment. This is one of the first studies where this type of source has been used. The analysis of seismic data corresponding to one of the reflection profiles (L3) allows us to delineate sectors with different glacier structure (accumulation and ablation zones) without using glaciological data. Moreover, vertical discontinuities were detected by the presence of back-scattered energy and the abrupt change in frequency content of first arrivals shown in shot records. After the raw data analysis, standard processing led us to a clear seismic image of the underlying bed topography, which can be correlated with the ice flow velocity anomalies. The information obtained from seismic data on the internal structure of the glacier, location of fracture zones and the topography of the ice-bed interface constrains the glacial dynamics of Johnsons Glacier.

  1. Comprehensive approach to ocular consequences of Stevens Johnson Syndrome - the aftermath of a systemic condition.

    Science.gov (United States)

    Iyer, Geetha; Srinivasan, Bhaskar; Agarwal, Shweta; Kamala Muralidharan, Seema; Arumugam, Sumathi

    2014-03-01

    Stevens Johnson Syndrome (SJS) can lead to end stage corneal blindness. This study describes the comprehensive treatment measures and their outcomes in the management of ocular sequelae and complications of SJS. Four hundred sixty-four eyes of 232 patients of SJS who underwent surgical intervention (punctal cautery, mucus membrane grafting for lid margin keratinisation, fornix reconstructive procedures, tectonic procedures, keratoplasty and keratoprosthesis) were studied. It was a non-comparative, retrospective, interventional case series. The primary outcome was the change in the best corrected visual acuity (BCVA). Secondary outcome measures included an improvement in the ocular surface status as indicated by corneal epithelial fluorescein staining and Schirmer's I strip wetting. The BCVA and the ocular surface status improved and/or stabilized in > 70 % of eyes following punctal cautery (n = 160) and > 80 % of eyes following lid margin mucus membrane grafting (n = 238). BCVA improved in 50 % of eyes following fornix reconstructive procedures (n = 24) with COMET (n = 6), in 63.9 % eyes with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) lens (n = 36), in 81.8 % of eyes after cataract surgery (n = 22). A BCVA of ≥20/200 was achieved in 72.34 % of eyes following keratoprostheses procedures (n = 47). The mean duration of follow up was 53.3 ± 15.2 months. The ocular sequelae of Stevens Johnson Syndrome can be blinding. They need to be identified and addressed early to retard the continued deterioration of the ocular surface. Our study aims to highlight the problem as well as the importance of comprehensive measures in the management of this potentially blinding disorder.

  2. Lessons in power: Lyndon Johnson revealed. A conversation with historian Robert A. Caro.

    Science.gov (United States)

    Caro, Robert A

    2006-04-01

    No one can lead who does not first acquire power, and no leader can be great who does not know how to use that power. The trouble is that the combination of the two skills is rare. Amassing power requires ambition, a focused pragmatism, and a certain ruthlessness that is often at odds with the daring, idealistic vision needed to achieve great things with that power. The tension is as real in business as it is in politics. This magazine is replete with examples of successful senior managers who could not make the switch from ambitious executive to corporate leader because they did not know what to do with the power they had so expertly accumulated. Robert Caro is a student of power. For the past 27 years, the two-time Pulitzer prize-winning biographer of Robert Moses and Lyndon Johnson has focused on the question of how Johnson amassed and wielded power. Caro's deep understanding of the inner workings of power offers senior executives a nuanced picture of leadership at the highest level. In this wide-ranging conversation, Caro shares his insights about the nature of power, the complexity of ambition, and the role that the greater good can play in the making of a leader. Power doesn't always corrupt, he insists. But what it invariably does is reveal a leader's true nature. "Today, when CEOs have acquired more and more power to change our lives," Caro says,"they have become like presidents in their own right, and they, too, need to align themselves with something greater than themselves if they hope to become truly great leaders."

  3. Left-handed Children in Singapore.

    Science.gov (United States)

    Gan, Linda

    1998-01-01

    Used teacher questionnaires to examine incidence of left-handedness in nearly 2,800 Singaporean children, racial differences in this left-handed population, and educational provisions in preschool and primary school. Findings indicated that 7.5% of preschoolers and 6.3% of primary children were left-handed, with a higher proportion being Chinese…

  4. The Left-Handed: "Their Sinister" History.

    Science.gov (United States)

    Costas, Elaine Fowler

    The history of left-handedness can provide teachers and parents a better understanding of left-handed children and give those children more pride in their difference. No child should be made to feel that he or she is abnormal because of using the left hand, although some specific instruction for these students is necessary in handwriting. Many…

  5. Geology and mineral resources of the Johnson City, Phenix City, and Rome 10 x 20 NTMS quadrangles

    International Nuclear Information System (INIS)

    Karfunkel, B.S.

    1981-11-01

    This document provides geologic and mineral resources data for the Savannah River Laboratory-National Uranium Resource Evaluation hydrogeochemical and stream-sediment reports for the Johnson City, Phenix City, and Rome 1 0 x 2 0 National Topographic Map Series quadrangles in the southeastern United States

  6. Education in Time of War: George Johnson and the Commission on American Citizenship of the Catholic University of America

    Science.gov (United States)

    Elias, John L.

    2009-01-01

    Times of war are times of crisis for theologians and educators. This article examines how Msgr. George Johnson, the vice president of the Religious Education Association and the most prominent Catholic educator in the 1930s and 1940s, dealt with the ethical and educational issues surrounding U.S. involvement in the Second World War. It argues that…

  7. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis : Are Drug Dictionaries Correctly Informing Physicians Regarding the Risk?

    NARCIS (Netherlands)

    Haddad, Cynthia; Sidoroff, Alexis; Kardaun, Sylvia H.; Mockenhaupt, Maja; Creamer, Daniel; Dunant, Ariane; Roujeau, Jean-Claude

    Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe drug reactions associated with high mortality and multiple incapacitating sequelae. In the past 20 years, two large multinational case control studies, published in 1995 and 2008, had identified different degrees of drug

  8. The Woodcock-Johnson Tests of Cognitive Abilities III's Cognitive Performance Model: Empirical Support for Intermediate Factors within CHC Theory

    Science.gov (United States)

    Taub, Gordon E.; McGrew, Kevin S.

    2014-01-01

    The Woodcock-Johnson Tests of Cognitive Ability Third Edition is developed using the Cattell-Horn-Carroll (CHC) measurement-theory test design as the instrument's theoretical blueprint. The instrument provides users with cognitive scores based on the Cognitive Performance Model (CPM); however, the CPM is not a part of CHC theory. Within the…

  9. Transformation of an empirical distribution to normal distribution by the use of Johnson system of translation and symmetrical quantile method

    OpenAIRE

    Ludvík Friebel; Jana Friebelová

    2006-01-01

    This article deals with approximation of empirical distribution to standard normal distribution using Johnson transformation. This transformation enables us to approximate wide spectrum of continuous distributions with a normal distribution. The estimation of parameters of transformation formulas is based on percentiles of empirical distribution. There are derived theoretical probability distribution functions of random variable obtained on the base of backward transformation standard normal ...

  10. Factors Affecting Student Loan Default Rate at Johnson County Community College: A Multivariate Analysis of Student Loan Default and Repayment between Years 2006 and 2008

    Science.gov (United States)

    Butler, Cassandra

    2012-01-01

    This study utilized a quantitative design using archival data from Johnson County Community College (JCCC), located in Johnson County, Kansas, and the Office of Financial Aid for students who graduated, withdrew or dropped out of the college in academic years 2006, 2007 and 2008. Because this study used archival data, we can only show…

  11. Flavoured Dark Matter moving left

    Science.gov (United States)

    Blanke, Monika; Das, Satrajit; Kast, Simon

    2018-02-01

    We investigate the phenomenology of a simplified model of flavoured Dark Matter (DM), with a dark fermionic flavour triplet coupling to the left-handed SU(2) L quark doublets via a scalar mediator. The DM-quark coupling matrix is assumed to constitute the only new source of flavour and CP violation, following the hypothesis of Dark Minimal Flavour Violation. We analyse the constraints from LHC searches, from meson mixing data in the K, D, and B d,s meson systems, from thermal DM freeze-out, and from direct detection experiments. Our combined analysis shows that while the experimental constraints are similar to the DMFV models with DM coupling to right-handed quarks, the multitude of couplings between DM and the SM quark sector resulting from the SU(2) L structure implies a richer phenomenology and significantly alters the resulting impact on the viable parameter space.

  12. Control of refractory status epilepticus precipitated by anticonvulsant withdrawal using left vagal nerve stimulation: a case report.

    Science.gov (United States)

    Patwardhan, Ravish V; Dellabadia, John; Rashidi, Mahmoud; Grier, Laurie; Nanda, Anil

    2005-08-01

    To describe a case of left vagal nerve stimulation (VNS) resulting in immediate cessation of status epilepticus (SE) with good neurological outcome. A 30-year-old man with medically intractable seizures including episodes of SE was successfully treated using left VNS. After requiring discontinuation of phenytoin, valproic acid, carbamazepine, and topiramate because of severe allergic reactions resembling Stevens-Johnson syndrome, the patient required pentobarbital coma along with phenobarbital, tiagabine, and levetiracetam for seizure frequency reduction. He underwent left vagal nerve stimulator placement after nearly 9 days of barbiturate-induced coma, with stimulation initiated in the operating room. On the following day, electroencephalography revealed resolution of previously observed periodic lateral epileptiform discharges and the patient was free of seizures. Prestimulation seizure frequency was recorded at 59 times a day, with some seizures enduring 45 minutes despite barbiturate coma. Poststimulation, the patient has been free of seizures for 19 days and is presently taking only levetiracetam and phenobarbital, from which he continues to be successfully weaned without seizures. He is awake, alert, and can recall events leading up to his seizures, with good long-term memory and residual left upper extremity and lower extremity weakness. This case illustrates the role of left vagal stimulation in the treatment of SE and otherwise medically intractable seizures caused by allergic reactions. To our knowledge, this is the first case in the world literature for adults reporting cessation of SE after VNS. Another case with a similar improvement has been reported in the pediatric population.

  13. Mucous membrane grafting for the post-Steven-Johnson syndrome symblepharon: A case report

    Directory of Open Access Journals (Sweden)

    Jayanta Kumar Das

    2011-01-01

    Full Text Available An 18-year-old woman was referred with late sequelae of chloroquine-induced Steven-Johnson syndrome. At the time of presentation, the symblepharon was involving the upper lids to almost the whole of the cornea, and part of the lower bulbar conjunctiva with the lower lid bilaterally. Other ocular examinations were not possible due to the symblepharon. B-scan ultrasonography revealed acoustically clear vitreous, normal chorioretinal thickness, and normal optic nerve head, with an attached retina. Conjunctivo-corneal adhesion released by superficial lamellar dissection of the cornea. Ocular surface reconstruction was carried out with a buccal mucous membrane. A bandage contact lens was placed over the cornea followed by the symblepharon ring to prevent further adhesion. The mucosal graft was well taken up along with corneal re-epithelization. Best corrected visual acuity of 20/120 in both sides after 1 month and 20/80 after 3 months was achieved and maintained till the 2.5-year follow-up.

  14. Turning point: the Robert Wood Johnson Foundation's effort to revitalize public health at the state level.

    Science.gov (United States)

    Hassmiller, Susan

    2002-01-01

    The Robert Wood Johnson (RWJ) Foundation initiated Turning Point in collaboration with the W.K. Kellogg Foundation (Kellogg) in 1997. The purpose of this major national initiative was to strengthen the public health infrastructure in the United States so that states, local communities, and their public health agencies might respond to the challenge to protect and improve the public's health in the 21st century. RWJ funded 21 states and Kellogg funded 43 communities to work together to create a new way of thinking about how health could be improved and who should be involved. Although the ultimate outcome was to improve health, both foundations expected diverse partnerships to work together to create strategic health improvement plans at both the community and state levels. The foundations funded a variety of strategies within those health improvement plans during an implementation phase. The premise in funding partnerships, as opposed to a single entity, was that effective public health systems would be developed best through a shared responsibility (including the private sector) for the health of a community.

  15. NASA Johnson Space Center Usability Testing and Analysis facility (UTAF) Overview

    Science.gov (United States)

    Whitmore, Mihriban; Holden, Kritina L.

    2005-01-01

    The Usability Testing and Analysis Facility (UTAF) is part of the Space Human Factors Laboratory at the NASA Johnson Space Center in Houston, Texas. The facility performs research for NASA's HumanSystems Integration Program, under the HumanSystems Research and Technology Division. Specifically, the UTAF provides human factors support for space vehicles, including the International Space Station, the Space Shuttle, and the forthcoming Crew Exploration Vehicle. In addition, there are ongoing collaborative research efforts with external corporations and universities. The UTAF provides human factors analysis, evaluation, and usability testing of crew interfaces for space applications. This includes computer displays and controls, workstation systems, and work environments. The UTAF has a unique mix of capabilities, with a staff experienced in both cognitive human factors and ergonomics. The current areas of focus are: human factors applications in emergency medical care and informatics; control and display technologies for electronic procedures and instructions; voice recognition in noisy environments; crew restraint design for unique microgravity workstations; and refinement of human factors processes and requirements. This presentation will provide an overview of ongoing activities, and will address how the UTAF projects will evolve to meet new space initiatives.

  16. NASA Johnson Space Center Usability Testing and Analysis Facility (WAF) Overview

    Science.gov (United States)

    Whitmore, M.

    2004-01-01

    The Usability Testing and Analysis Facility (UTAF) is part of the Space Human Factors Laboratory at the NASA Johnson Space Center in Houston, Texas. The facility provides support to the Office of Biological and Physical Research, the Space Shuttle Program, the International Space Station Program, and other NASA organizations. In addition, there are ongoing collaborative research efforts with external businesses and universities. The UTAF provides human factors analysis, evaluation, and usability testing of crew interfaces for space applications. This includes computer displays and controls, workstation systems, and work environments. The UTAF has a unique mix of capabilities, with a staff experienced in both cognitive human factors and ergonomics. The current areas of focus are: human factors applications in emergency medical care and informatics; control and display technologies for electronic procedures and instructions; voice recognition in noisy environments; crew restraint design for unique microgravity workstations; and refinement of human factors processes. This presentation will provide an overview of ongoing activities, and will address how the projects will evolve to meet new space initiatives.

  17. The development and technology transfer of software engineering technology at NASA. Johnson Space Center

    Science.gov (United States)

    Pitman, C. L.; Erb, D. M.; Izygon, M. E.; Fridge, E. M., III; Roush, G. B.; Braley, D. M.; Savely, R. T.

    1992-01-01

    The United State's big space projects of the next decades, such as Space Station and the Human Exploration Initiative, will need the development of many millions of lines of mission critical software. NASA-Johnson (JSC) is identifying and developing some of the Computer Aided Software Engineering (CASE) technology that NASA will need to build these future software systems. The goal is to improve the quality and the productivity of large software development projects. New trends are outlined in CASE technology and how the Software Technology Branch (STB) at JSC is endeavoring to provide some of these CASE solutions for NASA is described. Key software technology components include knowledge-based systems, software reusability, user interface technology, reengineering environments, management systems for the software development process, software cost models, repository technology, and open, integrated CASE environment frameworks. The paper presents the status and long-term expectations for CASE products. The STB's Reengineering Application Project (REAP), Advanced Software Development Workstation (ASDW) project, and software development cost model (COSTMODL) project are then discussed. Some of the general difficulties of technology transfer are introduced, and a process developed by STB for CASE technology insertion is described.

  18. Infectious Keratitis in Limbal Stem Cell Deficiency: Stevens-Johnson Syndrome Versus Chemical Burn.

    Science.gov (United States)

    Kang, Byeong Soo; Kim, Mee Kum; Wee, Won Ryang; Oh, Joo Youn

    2016-01-01

    To investigate the incidence, clinical and microbiological characteristics, risk factors, and therapeutic outcome of infectious keratitis in patients with limbal stem cell deficiency (LSCD) related to Stevens-Johnson syndrome (SJS) and corneal chemical burn. Medical records of 90 eyes of 59 patients who were diagnosed with LSCD resulting from SJS (52 eyes of 29 patients) or corneal chemical burn (38 eyes of 30 patients) were reviewed. Infectious keratitis developed in 35% of LSCD patients with SJS (18 eyes, 14 patients) and in 18% of those with chemical burn (7 eyes, 7 patients). The development of infectious keratitis in SJS was significantly associated with the severity of chronic ocular surface complications in the cornea, conjunctiva, and eyelids and with the use of topical corticosteroids during the disease course. All cases of infectious keratitis following chemical burn occurred in patients with grade III or IV burn by Roper-Hall classification. Approximately 83% of culture-proven cases of infectious keratitis were bacterial infection, most of which (80%) were caused by Gram-positive bacteria. For resolution of infection, 17 eyes (68%) received surgery in addition to medical treatment, whereas 8 eyes (32%) received medical treatment alone. After infection resolution, the final visual acuity was decreased in 10 eyes (40%) compared with before infection. Infectious keratitis is a common complication of LSCD associated with SJS or severe chemical burn to the cornea. Despite medical and surgical treatments, the visual outcome is poor.

  19. Determination of Johnson-Cook Plasticity Model Parameters for Inconel718

    Science.gov (United States)

    Farahani, H. K.; Ketabchi, M.; Zangeneh, Sh.

    2017-11-01

    In order to simulate foreign object damage (FOD) phenomenon in aircraft high-pressure compressor blades made of a nickel-based super-alloy, Johnson-Cook (J-C) plasticity model was used. For prediction of material's plastic behavior at temperature of 400 °C (working temperature of the blades) in the range of strain rates associated with the FOD phenomenon (in order of 106 s-1), material parameters of A, B, C, n and m for the J-C plasticity model had to be determined experimentally. Parameters of A, B and n with values of 1108, 699 MPa and 0.5189, respectively, were obtained from quasi-static tensile tests. Moreover, m was determined to be 1.2861, also through quasi-static tensile tests with a strain rate of 1 s-1 at three temperatures of 475, 550 and 625 °C. However, in order to determine C, firstly a steel ball was impacted on the surface of a flat specimen made of a precipitation-hardening alloy, and then, the impact site was 3D scanned to obtain the induced crater profile. Finally, the impact test (ballistic) was simulated using Abaqus, and a C value of 0.0085 was determined by comparing the actual crater profile with the one obtained from the simulation through a trial-and-error approach.

  20. Stevens–Johnson syndrome/toxic epidermal necrolysis caused by cefadroxil in a cat

    Directory of Open Access Journals (Sweden)

    Roberta Sartori

    2016-06-01

    Full Text Available Case summary A 5-year-old, spayed female, indoor-only domestic shorthair cat was referred with an acute history of multifocal cutaneous and mucocutaneous erosive-ulcerative lesions and skin detachment. The lesions occurred on the seventh day of therapy with cefadroxil. Erosive-ulcerative and occasionally crusted lesions were apparent on the medial and lateral canthus of both eyes, ventral neck, abdomen, perivulvar region, periungual skin and medial aspect of the front and hindlimbs. Diffuse and severe exfoliation was present on the dorsum and tail base and in both external ear canals. The cat was also dehydrated, tachycardic and febrile. Histopathological examination revealed extensive epidermal ulceration, interface dermatitis with vacuolar degeneration, apoptosis at multiple epidermal levels and basal, suprabasal and spinous dermoepidermal detachment. The histopathological diagnosis was consistent with Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN. The recently reported Algorithm of Drug Causality in Epidermal Necrolysis (ALDEN, currently used in human medicine, was applied and a score of +6 was calculated; this supported the view that SJS/TEN in this cat was very likely to be associated with cefadroxil administration. Relevance and novel information This clinical communication reports cefadroxil as a very probable cause of SJS/TEN in a cat; the ALDEN was applied in this case and supported diagnosis.

  1. LARGE SCALE REFRIGERATION PLANT FOR GROUND TESTING THE JAMES WEBB TELESCOPE AT NASA JOHNSON SPACE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    P. Arnold, Lutz Decker, D. Howe, J. Urbin, Jonathan Homan, Carl Reis, J. Creel, V. Ganni, P. Knudsen, A. Sidi-Yekhlef

    2010-04-01

    The James Webb Telescope is the successor to the Hubble Telescope and will be placed in an orbit of 1.5 million km from earth. Before launch in 2014, the telescope will be tested in NASA Johnson Space Center's (JSC) space simulation chamber, Chamber A. The tests will be conducted at deep space conditions. Chamber A's helium cryo-panels are currently cooled down to 20 K by two Linde 3.5 kW helium refrigerators. The new 12.5 kW, 20-K helium coldbox described in this paper is part of the upgrade to the chamber systems for this large test program. The Linde coldbox will provide refrigeration in several operating modes where the temperature of the chamber is being controlled with a high accuracy due to the demanding NASA test requirements. The implementation of two parallel expansion turbine strings and the Ganni cycle—Floating Pressure process results in a highly efficient and flexible process that minimizes the electrical input power. This paper will describe the collaboration and execution of the coldbox project.

  2. The Johnson Space Center Management Information Systems (JSCMIS): An interface for organizational databases

    Science.gov (United States)

    Bishop, Peter C.; Erickson, Lloyd

    1990-01-01

    The Management Information and Decision Support Environment (MIDSE) is a research activity to build and test a prototype of a generic human interface on the Johnson Space Center (JSC) Information Network (CIN). The existing interfaces were developed specifically to support operations rather than the type of data which management could use. The diversity of the many interfaces and their relative difficulty discouraged occasional users from attempting to use them for their purposes. The MIDSE activity approached this problem by designing and building an interface to one JSC data base - the personnel statistics tables of the NASA Personnel and Payroll System (NPPS). The interface was designed against the following requirements: generic (use with any relational NOMAD data base); easy to learn (intuitive operations for new users); easy to use (efficient operations for experienced users); self-documenting (help facility which informs users about the data base structure as well as the operation of the interface); and low maintenance (easy configuration to new applications). A prototype interface entitled the JSC Management Information Systems (JSCMIS) was produced. It resides on CIN/PROFS and is available to JSC management who request it. The interface has passed management review and is ready for early use. Three kinds of data are now available: personnel statistics, personnel register, and plan/actual cost.

  3. Role of Scleral Contact Lenses in Management of Coexisting Keratoconus and Stevens-Johnson Syndrome.

    Science.gov (United States)

    Rathi, Varsha M; Taneja, Mukesh; Dumpati, Srikanth; Mandathara, Preeji S; Sangwan, Virender S

    2017-10-01

    To report the rare coexistence of keratoconus and Stevens-Johnson syndrome (SJS) managed with scleral contact lenses (ScCLs). This is a retrospective case series. Five patients (9 eyes) who had coexisting SJS and corneal ectasia were identified from the database during the 2-year period. Diagnosis of SJS was based on a positive history of drug reactions, signs of ocular surface disease, and the presence of keratinization of lid margins. Keratoconus was diagnosed by slit-lamp biomicroscopy. Five eyes of 3 patients had coexisting SJS and keratoconus and were dispensed with ScCLs (PROSE, prosthetic replacement of the ocular surface ecosystem; Boston Foundation for Sight, Needham Heights, MA). All these patients had photophobia. Visual acuity improved in all these patients with ScCL wear. Two patients (4 eyes) were excluded from this study because they had SJS with generalized corneal thinning from limbus to limbus, corneal opacification, and pannus. One patient developed deep vessels in the cornea on prolonged ScCL wear. Reduction in the ScCL wear schedule and change of material with a higher Dk resulted in regression of vascularization. Case 3 developed conjunctival congestion and was uncomfortable wearing ScCLs, although visual acuity was 20/40. He discontinued using ScCL wear. Keratoconus, a noninflammatory condition of the cornea coexisted with inflammatory SJS. Managing such patients with ScCLs may improve vision and comfort.

  4. Mucous membrane grafting for the post-Steven-Johnson syndrome symblepharon: a case report.

    Science.gov (United States)

    Das, Jayanta Kumar; Medhi, Jnanankar; Chakravarty, Ranjay; Soibam, Ronel

    2011-01-01

    An 18-year-old woman was referred with late sequelae of chloroquine-induced Steven-Johnson syndrome. At the time of presentation, the symblepharon was involving the upper lids to almost the whole of the cornea, and part of the lower bulbar conjunctiva with the lower lid bilaterally. Other ocular examinations were not possible due to the symblepharon. B-scan ultrasonography revealed acoustically clear vitreous, normal chorioretinal thickness, and normal optic nerve head, with an attached retina. Conjunctivo-corneal adhesion released by superficial lamellar dissection of the cornea. Ocular surface reconstruction was carried out with a buccal mucous membrane. A bandage contact lens was placed over the cornea followed by the symblepharon ring to prevent further adhesion. The mucosal graft was well taken up along with corneal re-epithelization. Best corrected visual acuity of 20/120 in both sides after 1 month and 20/80 after 3 months was achieved and maintained till the 2.5-year follow-up.

  5. Diff-Quik cytologic recognition of Chlamydophila psittaci in orolabial lesions of Stevens-Johnson Syndrome.

    Science.gov (United States)

    Reyes, Cesar V

    2010-01-01

    Chlamydophila psittaci causes psittacosis, an ornithosis acquired usually from infected birds. The disease is often focal and pneumonic but on rare instances can be protean and fatal. Diagnosis is by Chlamydophila serology, which may take as long as 21 days or more. The recovery of the organisms from mice, eggs or tissue culture inoculated with the patient's blood or sputum is tedious and dangerous for laboratory personnel. On occasion, C psittaci inclusion bodies have also been detected in infected cells by fluorescent antibody, Giemsa or Gimenez staining. This report describes heretofore not previously reported recognition of the causative organisms in Diff-Quik-stained clinical cytologic materials. A 17-year-old man presented with fever and sore throat, associated with Steven-Johnson syndrome, of 6 days' duration. In the touch and scrape smears of the orolabial mucosal lesions, C psittaci inclusion bodies were recognizable in Diff-Quik-stained but not with Papanicolaou-stained smears and Gram stain. There were few to numerous organisms per macrophage, which were enlarged or bloated and usually collared by polymorphonuclear leukocytes. The diagnosis was supported by a therapeutic trial with doxycycline and confirmed by a positive third serological tests for C psittaci 3 weeks after discharge. In a suspected or probable case of ornithosis, a rapid diagnosis of C psittaci inclusion bodies is possible in clinical cytology materials using Diff-Quik.

  6. Genetic Markers and Danger Signals in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

    Directory of Open Access Journals (Sweden)

    Wen-Hung Chung

    2010-01-01

    Full Text Available Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are life-threatening adverse reactions, which could be induced by a variety of drugs. It was proposed that human leukocyte antigen (HLA-restricted presentation of antigens (drugs or their metabolites to T lymphocytes initiates the immune reactions of SJS/ TEN. However, the genetic susceptibility and the exact pathogenesis were not clear until the recent studies. We first identified that HLA-B*1502 is strongly associated with carbamazepine (CBZ-induced SJS/TEN and HLA-B*5801 with allopurinol-SJS/TEN in Han Chinese. The same associations had been validated across different human populations. For the downstream danger signals, Fas-Fas ligand (FasL and perforin/granzyme B had been advocated as cytotoxic mediators for keratinocyte death in SJS/TEN. However, expression levels of these cytotoxic proteins from the skin lesions were too low to explain the distinct and extensive epidermal necrosis. Our recent study identified that the granulysin, a cytotoxic protein released from cytotoxic T cells or natural killer (NK cells, is a key mediator for disseminated keratinocyte death in SJS/TEN. This article aims to provide an overview of both of the genomic and immunologic perspectives of SJS/TEN. These studies give us a better understanding of the immune mechanisms, biomarkers for disease prevention and early diagnosis, as well as providing the therapeutic targets for the treatments of SJS/TEN.

  7. Optoelectronic Response of GeZn2O4 through the Modified Becke—Johnson Potential

    Science.gov (United States)

    Iftikhar, Ahmad; Amin, B.; Maqbool, M.; S., Muhammad; Murtaza, G.; S., Ali; A. Noor, N.

    2012-09-01

    A first-principles technique capable of describing the nearly excited states of semiconductors and insulators, namely the modified Becke—Johnson (mBJ) potential approximation, is used to investigate the electronic band structure and optical properties of spinel oxides: GeZn2O4. The predicted band gaps using the mBJ approximation are significantly more accurate than the proposed previous theoretical work using the common LDA and GGA. Band gap dependent optical parameters, like the dielectric constant, index of refraction, reflectivity and optical conductivity are calculated and analyzed. The results from the dielectric constant shows that the numerical value of the static dielectric, after dropping constantly, becomes less than zero and the material exhibits metallic behavior. The refractive index also drops below unity for photons higher than 18 eV, which indicates that the velocities of incident photons are greater than the velocity of light. However, these phenomena can be explained by the fact that a signal must be transmitted as a wave packet rather than a monochromatic wave. This comprehensive theoretical study of the optoelectronic properties predicts that these materials can effectively be used in optical devices.

  8. Johnson Space Center's Solar and Wind-Based Renewable Energy System

    Science.gov (United States)

    Vasquez, A.; Ewert, M.; Rowlands, J.; Post, K.

    2009-01-01

    The NASA Johnson Space Center (JSC) in Houston, Texas has a Sustainability Partnership team that seeks ways for earth-based sustainability practices to also benefit space exploration research. A renewable energy gathering system was installed in 2007 at the JSC Child Care Center (CCC) which also offers a potential test bed for space exploration power generation and remote monitoring and control concepts. The system comprises: 1) several different types of photovoltaic panels (29 kW), 2) two wind-turbines (3.6 kW total), and 3) one roof-mounted solar thermal water heater and tank. A tie to the JSC local electrical grid was provided to accommodate excess power. The total first year electrical energy production was 53 megawatt-hours. A web-based real-time metering system collects and reports system performance and weather data. Improvements in areas of the CCC that were detected during subsequent energy analyses and some concepts for future efforts are also presented.

  9. Summary of investigations of uranium deposits in the Pumpkin Buttes area, Johnson and Campbell Counties, Wyoming

    Science.gov (United States)

    Troyer, Max L.; McKay, Edward J.; Soister, Paul E.; Wallace, Stewart R.

    1954-01-01

    Uranium minerals were discovered in the Pumpkin Buttes area, Campbell and Johnson Counties, Wyo., by the U. S. Geological Survey in October 1951. From June to November 1952, an area of about 750 square miles was examined for uranium deposits, and 211 localities having abnormally high radioactivity were found; uranium minerals are visible at 121 of these localities. All known uranium mineralization in the area is restricted to sandstones of the Wasatch formation, except sparsely disseminated uranium in the sandstone of the White River formation, which caps the Pumpkin Buttes, mid several localities on the Great Pine Ridge southwest of the Pumpkin Buttes where iron-saturated sandstone and clinker in the Fort Union formation have above-normal radioactivity. The uranium occurrences in the Wasatch formation are in a red sandstone zone 450 to 900 feet above the base of the formation and are of two types: small concretionary masses of uranium, iron, manganese and vanadium minerals in sandstone, and irregular zones in which uranium minerals are disseminated in sandstone. The second type is usually larger but of lower grade than the first. Most of the localities at which uranium occurs are in a north-trending belt about 60 miles long and 18 miles in maximum width.

  10. Taxonomic revision of the Afrotropical genus Megatrigon Johnson, 1898 (Diptera: Syrphidae

    Directory of Open Access Journals (Sweden)

    Dieter Doczkal

    2016-10-01

    Full Text Available The genus-group taxon Megatrigon Johnson, 1898, stat. nov., is revised and treated as a valid genus within the Merodontini (= Eumerini. Extensive diagnoses are given for the genus and for its three constituent species groups: argenteus group [11 spp.], nivalis group [monotypic], sexfasciatus group [3 spp.]. Five new generic combinations are proposed within Megatrigon: M. argenteus (Walker, 1852 comb. nov., M. flavimarginatus (Hull, 1964 comb. nov., M. jacobi (Hervé-Bazin, 1913 comb. nov., M. nivalis (Hull, 1964 comb. nov. and M. ochreatus (Hull, 1964 comb. nov. All species of the argenteus group are revised and nine new species are described: Megatrigon apiformis sp. nov., M. argentifrons sp. nov., M. argentimaculatus sp. nov., M. cooksoni sp. nov., M. immaculatus sp. nov., M. magnicornis sp. nov., M. natalensis sp. nov., M. sexmaculatus sp. nov., M. tabanoides sp. nov. Within the sexfasciatus group, M. jacobi (Hervé-Bazin, 1913 comb. nov. is treated as a senior synonym of Eumerus connexus Hull, 1964 syn. nov., but no further work is done at the species level due to insufficient material.

  11. Organic Contamination Baseline Study in NASA Johnson Space Center Astromaterials Curation Laboratories

    Science.gov (United States)

    Calaway, Michael J.; Allen, Carlton C.; Allton, Judith H.

    2014-01-01

    Future robotic and human spaceflight missions to the Moon, Mars, asteroids, and comets will require curating astromaterial samples with minimal inorganic and organic contamination to preserve the scientific integrity of each sample. 21st century sample return missions will focus on strict protocols for reducing organic contamination that have not been seen since the Apollo manned lunar landing program. To properly curate these materials, the Astromaterials Acquisition and Curation Office under the Astromaterial Research and Exploration Science Directorate at NASA Johnson Space Center houses and protects all extraterrestrial materials brought back to Earth that are controlled by the United States government. During fiscal year 2012, we conducted a year-long project to compile historical documentation and laboratory tests involving organic investigations at these facilities. In addition, we developed a plan to determine the current state of organic cleanliness in curation laboratories housing astromaterials. This was accomplished by focusing on current procedures and protocols for cleaning, sample handling, and storage. While the intention of this report is to give a comprehensive overview of the current state of organic cleanliness in JSC curation laboratories, it also provides a baseline for determining whether our cleaning procedures and sample handling protocols need to be adapted and/or augmented to meet the new requirements for future human spaceflight and robotic sample return missions.

  12. Measurement of the Boltzmann constant by Johnson noise thermometry using a superconducting integrated circuit

    Science.gov (United States)

    Urano, C.; Yamazawa, K.; Kaneko, N.-H.

    2017-12-01

    We report on our measurement of the Boltzmann constant by Johnson noise thermometry (JNT) using an integrated quantum voltage noise source (IQVNS) that is fully implemented with superconducting integrated circuit technology. The IQVNS generates calculable pseudo white noise voltages to calibrate the JNT system. The thermal noise of a sensing resistor placed at the temperature of the triple point of water was measured precisely by the IQVNS-based JNT. We accumulated data of more than 429 200 s in total (over 6 d) and used the Akaike information criterion to estimate the fitting frequency range for the quadratic model to calculate the Boltzmann constant. Upon detailed evaluation of the uncertainty components, the experimentally obtained Boltzmann constant was k=1.380 6436× {{10}-23} J K-1 with a relative combined uncertainty of 10.22× {{10}-6} . The value of k is relatively -3.56× {{10}-6} lower than the CODATA 2014 value (Mohr et al 2016 Rev. Mod. Phys. 88 035009).

  13. Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation.

    Science.gov (United States)

    Eralp, Y; Aydiner, A; Taş, F; Saip, P; Topuz, E

    2001-08-01

    A 28-year-old female patient with a recent history of breast carcinoma was referred to our clinic with generalized necrotic skin eruptions and severe mucosal erosions, which developed right after the completion of cranial radiotherapy for brain metastases. She had been receiving prophylactic diphenylhydantoin treatment 100 mg three times daily during radiation therapy. The extensive involvement of the oral mucosa with conjunctivitis and synechiae of the eyelids, facial swelling, and extension of the rash over the trunk and shoulders with bullous detachment of less than 10% of the total body surface strongly suggested Stevens-Johnson syndrome caused by phenytoin treatment in our patient. There has been conflicting evidence on the role of radiotherapy in the increased risk of severe drug reactions. Although various authors have emphasized the augmented rate of severe mucocutaneous reactions caused by anticonvulsants given during radiotherapy and suggested discontinuing the prophylactic use of such drugs in patients with no history of seizures, others have argued in favor of prophylactic anticonvulsants. Given the high risk of seizures, reaching 20% in patients with brain tumors, and the low incidence of drug reactions, the suggestion of refraining from prophylactic anticonvulsants in the setting of primary or metastatic brain tumors is controversial.

  14. Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

    Science.gov (United States)

    Okamoto-Uchida, Yoshimi; Nakamura, Ryosuke; Sai, Kimie; Imatoh, Takuya; Matsunaga, Kayoko; Aihara, Michiko; Saito, Yoshiro

    2017-01-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Recent studies have revealed that the prevalence of SJS/TEN is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, non-genetic factors contributing to the etiology of SJS/TEN are largely unknown. This study aimed to assess the involvement of concurrent infection on the pathological states of SJS/TEN, examining the severity of cutaneous symptoms and ocular involvement as well as the time to onset in drug-induced SJS/TEN patients. We recruited 257 Japanese SJS/TEN patients from June 2006 to September 2013 through a nationwide case collection network and participating hospitals and reviewed the clinical information including patient backgrounds, primary disease and medication status. Association between infection and pathological states of SJS/TEN was assessed using univariate and multivariate analyses. The concurrent infectious group of SJS/TEN patients showed a significantly higher rate of exhibiting severer dermatological and ophthalmological phenotypes and an earlier onset of SJS/TEN than the non-infectious group. Our results suggest that the infection could be a risk factor to cause severer symptoms and earlier onset of SJS/TEN.

  15. The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK.

    Science.gov (United States)

    Frey, Noel; Jossi, Janine; Bodmer, Michael; Bircher, Andreas; Jick, Susan S; Meier, Christoph R; Spoendlin, Julia

    2017-06-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening mucocutaneous diseases. SJS/TEN mostly manifest as a reaction to new drug use, but little is known about their incidence and epidemiology. We conducted a large observational study on the epidemiology of SJS/TEN using data from the UK-based Clinical Practice Research Datalink. Among 551 validated SJS/TEN patients, we calculated an incidence rate of 5.76 SJS/TEN cases per million person-years between 1995 and 2013, which was consistent throughout the study period and was highest in patients aged 1-10 years and 80 years or older. Within a 1:4 matched case-control analysis, black and Asian patients were at a 2-fold risk of SJS/TEN when compared with white patients. Among patients with epilepsy and gout, odds ratios for SJS/TEN were significantly increased only in the presence of recent new drug treatment with antiepileptics or allopurinol, respectively. We observed statistically significant associations between SJS/TEN and pre-existing depression, lupus erythematosus, recent pneumonia, chronic kidney disease, and active cancer, but confounding by drug use needs to be followed up. This large and longitudinal observational study on the epidemiology of SJS/TEN contributes to the understanding of this still underinvestigated severe skin disease in a European and largely white study population. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Stevens-Johnson syndrome / toxic epidermal necrolysis: an Asia-Pacific perspective

    Science.gov (United States)

    2013-01-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions (SCAR) to drugs which are associated with significant morbidity and mortality. High risk drugs in Asia are similar to those reported worldwide. Human leukocyte antigen (HLA)-related risk alleles for carbamazepine and allopurinol SCAR are unique to Asians. Although prognostic scoring systems like the SCORTEN have been used for more than a decade, pitfalls and caveats need to be recognized, in particular in patients with multiple medical co-morbidities and systemic features in SJS/TEN. In centres without a tertiary Burns Centre, SJS/TEN patients can still be managed successfully in general and dermatology wards with well-executed supportive/nursing care. Controversy remains regarding the effectiveness of immunomodulation in reducing SJS/TEN morbidity, mortality and hastening re-epithelialization. Despite paucity of robust evidence, intravenous immunoglobulins and ciclosporin remain the most commonly used modalities worldwide. Acute and long-term ocular effects are an important source of morbidity for which emerging ophthalmic therapies appear promising. Quality of life issues have now become an important outcome in patients with SJS/TEN as they often impact survivors' future attitudes towards pharmacotherapy. Even though pharmacogenetic testing for high-risk drugs appears to be the panacea for preventing carbamazepine- and allopurinol-induced SJS/TEN in ethnic Asians, many issues remain before health regulators in our region can conclusively determine whether testing should be made mandatory or highly recommended as standard of care. PMID:24260726

  17. Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update.

    Science.gov (United States)

    Robert, Marie-Claude; Črnej, Alja; Shen, Lucy Q; Papaliodis, George N; Dana, Reza; Foster, C Stephen; Chodosh, James; Dohlman, Claes H

    2017-06-01

    To report our experience using intravenous infliximab for the treatment of tissue melt after Boston keratoprosthesis (B-KPro) types I and II in patients with autoimmune disease. Case series. We identified four patients who were treated with intravenous infliximab in the context of tissue melt after B-KPro. Stevens-Johnson syndrome-associated corneal blindness was the primary surgical indication for B-KPro implantation in all patients. Two patients received a B-KPro type I and two patients received a B-KPro type II. The patients received intravenous infliximab for skin retraction around B-KPro type II, melting of the carrier graft or leak. Treatment resulted in a dramatic decrease in inflammation and, in some cases, arrest of the melting process. Cost and patient adherence were limiting factors to pursuing infliximab therapy. In addition, one patient developed infusion reactions. Intravenous infliximab may be considered as globe- and sight-saving therapy for tissue melt after B-KPro.

  18. The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China

    Directory of Open Access Journals (Sweden)

    Shang-Chen Yang

    2018-01-01

    Full Text Available Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN. The most common offending drugs were antibiotics (29.5% and anticonvulsants (24.1%. Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%. Chinese patent medicines accounted for 5.4%. There were 76 (45.8% patients receiving systemic steroid and intravenous immunoglobulin (IVIG in combination therapy, especially for TEN (80.3%, and others were treated with systemic steroids alone. Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance. In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation.

  19. Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Aneline Casagranda

    2017-05-01

    Full Text Available Drug-induced severe cutaneous adverse reactions (SCARs include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS, and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis. The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group. Only a better understanding of the physiopathology of the SCARs could possibly explain these ambiguities and overlaps. We report a case of SCAR in an 86-year-old patient probably induced by allopurinol and simultaneously fulfilling the diagnostic criteria for DRESS and SJS, thus considered as an overlapping case of SCARs.

  20. Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature.

    Science.gov (United States)

    Casagranda, Aneline; Suppa, Mariano; Dehavay, Florence; Del Marmol, Véronique

    2017-01-01

    Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Only a better understanding of the physiopathology of the SCARs could possibly explain these ambiguities and overlaps. We report a case of SCAR in an 86-year-old patient probably induced by allopurinol and simultaneously fulfilling the diagnostic criteria for DRESS and SJS, thus considered as an overlapping case of SCARs.

  1. Modified Becke-Johnson exchange potential: improved modeling of lead halides for solar cell applications

    Directory of Open Access Journals (Sweden)

    Radi A. Jishi

    2016-01-01

    Full Text Available We report first-principles calculations, within density functional theory, on the lead halide compounds PbCl2, PbBr2, and CH3NH3PbBr3−xClx, taking into account spin-orbit coupling. We show that, when the modified Becke-Johnson exchange potential is used with a suitable choice of defining parameters, excellent agreement between calculations and experiment is obtained. The computational model is then used to study the effect of replacing the methylammonium cation in CH3NH3PbI3 and CH3NH3PbBr3 with either N2H5+or N2H3+, which have slightly smaller ionic radii than methylammonium. We predict that a considerable downshift in the values of the band gaps occurs with this replacement. The resulting compounds would extend optical absorption down to the near-infrared region, creating excellent light harvesters for solar cells.

  2. Lyndon B. Johnson Space Center (JSC) proposed dual-use technology investment program in intelligent robots

    Science.gov (United States)

    Erikson, Jon D.

    1994-01-01

    This paper presents an overview of the proposed Lyndon B. Johnson Space Center (JSC) precompetitive, dual-use technology investment project in robotics. New robotic technology in advanced robots, which can recognize and respond to their environments and to spoken human supervision so as to perform a variety of combined mobility and manipulation tasks in various sectors, is an obejective of this work. In the U.S. economy, such robots offer the benefits of improved global competitiveness in a critical industrial sector; improved productivity by the end users of these robots; a growing robotics industry that produces jobs and profits; lower cost health care delivery with quality improvements; and, as these 'intelligent' robots become acceptable throughout society, an increase in the standard of living for everyone. In space, such robots will provide improved safety, reliability, and productivity as Space Station evolves, and will enable human space exploration (by human/robot teams). The proposed effort consists of partnerships between manufacturers, universities, and JSC to develop working production prototypes of these robots by leveraging current development by both sides. Currently targeted applications are in the manufacturing, health care, services, and construction sectors of the U.S. economy and in the inspection, servicing, maintenance, and repair aspects of space exploration. But the focus is on the generic software architecture and standardized interfaces for custom modules tailored for the various applications allowing end users to customize a robot as PC users customize PC's. Production prototypes would be completed in 5 years under this proposal.

  3. The Johnson Space Center Experimental Impact Lab: Contributions Toward Understanding the Evolution of the Solar System

    Science.gov (United States)

    See, T. H.; Montes, R.

    2012-01-01

    Impact is the most common and only weathering phenomenon affecting all the planetary bodies (e.g., planets, satellites, asteroids, comets, etc.) in the solar system. NASA Johnson Space Center s Experimental Impact Laboratory (EIL) includes three accelerators that are used in support of research into the effects of impact on the formation and evolution of the solar system. They permit researchers to study a wide variety of phenomena associated with high-velocity impacts into a wide range of geologic targets and materials relevant to astrobiological studies. By studying these processes, researchers can investigate the histories and evolution of planetary bodies and the solar system as a whole. While the majority of research conducted in the EIL addresses questions involving planetary impacts, work involving spacecraft components has been performed on occasion. An example of this is the aerogel collector material flown on the Stardust spacecraft that traveled to Comet Wild-2. This capture medium was tested and flight qualified using the 5 mm Light-Gas Gun located in the EIL.

  4. Diversity dynamics: The experience of male Robert Wood Johnson Foundation nurse faculty scholars.

    Science.gov (United States)

    Brody, Abraham A; Farley, Jason E; Gillespie, Gordon L; Hickman, Ronald; Hodges, Eric A; Lyder, Courtney; Palazzo, Steven J; Ruppar, Todd; Schiavenato, Martin; Pesut, Daniel J

    Managing diversity dynamics in academic or clinical settings for men in nursing has unique challenges resulting from their minority status within the profession. The purpose of this study was to share challenges and lessons learned identified by male scholars in the Robert Wood Johnson Foundation Nurse Faculty Scholars program and suggest strategies for creating positive organizations promoting inclusive excellence. Multiple strategies including informal mentored discussions and peer-to-peer dialogue throughout the program, formal online surveys of scholars and National Advisory Committee members, and review of scholar progress reports were analyzed as part of the comprehensive evaluation plan of the program. Diversity dynamic issues include concerns with negative stereotyping, microaggression, gender intelligence, and differences in communication and leadership styles. Male nurse faculty scholars report experiencing both opportunities and challenges residing in a predominately female profession. This article attempts to raise awareness and suggest strategies to manage diversity dynamics in service of promoting the development of a culture of health that values diversity and inclusive excellence for both men and women in academic, research, and practice contexts. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Compression syndrome of the left renal vein

    Energy Technology Data Exchange (ETDEWEB)

    Justich, E.

    1982-04-01

    Severe compression of the left renal vein produces a pressure gradient between it and the inferior vena cava and results in changes in haemodynamics. The cause of the narrowing is usually the aorta, less commonly the superior mesenteric artery. Compression of the left renal vein may be responsible for a number of abnormalities such as primary varicoceles, primary varices of the ovarian, renal, pelvic and ureteric veins on the left, the more frequent occurrence of unilateral renal vein thrombosis on the left and the development of renovascular hypertension. One hundred and twenty-three selective phlebograms of the left renal vein and CT examinations of this structure in a further 87 patients acting as a control group were carried out. The significance of compression of the left renal vein as an aetiological factor in the development of the above mentioned abnormalities is discussed.

  6. Multiplicativity of left centralizers forcing additivity

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    Mohammad Sayed Tammam El-Sayiad

    2014-01-01

    Full Text Available A multiplicative left centralizer for an associative ring R is a map satisfying T(xy = T\\(xy for all x,y in R. T is not assumed to be additive. In this paper we deal with the additivity of the multiplicative left centralizers in a ring which contains an idempotent element. Specially, we study additivity for multiplicative left centralizers in prime and semiprime rings which contain an idempotent element.

  7. Anarchy, socialism and a Darwinian left.

    Science.gov (United States)

    Clarke, Ellen

    2006-03-01

    In A Darwinian left Peter Singer aims to reconcile Darwinian theory with left wing politics, using evolutionary game theory and in particular a model proposed by Robert Axelrod, which shows that cooperation can be an evolutionarily successful strategy. In this paper I will show that whilst Axelrod's model can give support to a kind of left wing politics, it is not the kind that Singer himself envisages. In fact, it is shown that there are insurmountable problems for the idea of increasing Axelrodian cooperation within a welfare state. My surprising conclusion will be that a Darwinian left worthy of the name would be anarchistic.

  8. What is Beyond Right/Left?

    DEFF Research Database (Denmark)

    Dyrberg, Torben Bech

    2009-01-01

    The article looks at New Labour's move beyond right/left in the mid/late 1990s, which is an occasion to spell out the nature of right/left and what it means for democracy. In contrast to both defenders and critics of this move I argue in the first part that right/left is not an empty label bound up...... right/left. I argue that the new hegemonic orientation is that of front/back, which designs political renewal as a response to the social changes cutting across the outdated lines of contestation of partisan politics. The democratic problem of this move lies in squeezing politics between technocratic...

  9. Uncovering Underlying Assumptions Regarding Education and Technology in Educational Reform Efforts A conversation with Dr. Larry Johnson

    Directory of Open Access Journals (Sweden)

    Gabriela Melano

    2000-11-01

    Full Text Available Educational systems around the world, and specifically in the United States, have long been awaiting for genuine reform efforts. Technology is often perceived as a panacea, if not as a crucial instrument in any educational reform effort. In a conversation with one of his students, Doctor Johnson discusses how the underlying assumptions embedded in our current schooling practices need to be seriously reviewed before any technology strategy is considered. New understandings, as opposed to mere information, is what schools need to reach in order to transform themselves. Finally, Dr. Johnson provides two brief examples, one in the United States and another in México, were hermeneutical approaches have been used for educational reform endeavors.

  10. Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities

    Directory of Open Access Journals (Sweden)

    Adegbenro Omotuyi John Fakoya

    2018-03-01

    Full Text Available Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies are associated with these conditions, with adverse drug reaction being the most common. Though the worldwide incidence of these conditions is recorded as low, diverse types of medication are being observed to lead to these conditions. This review compiles information on the details of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis, the pathophysiology, therapeutic management, and largely considers the drug-induced etiologies associated with these conditions.

  11. In-situ calibration of nuclear-plant platinum resistance thermometers using Johnson noise methods. Final report

    International Nuclear Information System (INIS)

    Blalock, T.V.; Shepard, R.L.

    1983-06-01

    Methods for in situ calibration of reactor plant platinum resistance thermometers using Johnson noise measurements were tested in the laboratory and in two operating reactors: Diablo Canyon and Sequoyah. The Johnson noise methods provide an absolute measurement of the thermometer temperature and can be compared with the dc calibration of the thermometers to confirm their calibration without removing the thermometers from the plant coolant loops. Inaccuracies of less than 0.1% were obtained with these methods for ideal situations where the noise measuring equipment could be connected directly to the installed thermometer terminals. For measurements made at the ends of long extension cables, inaccuracies were 0.5 to 1.0%, at best. Extension cables must be optimized and well characterized electrically to achieve such accuracies. Other factors that affect the accuracy of these methods were evaluated

  12. Famous people with Tourette's syndrome: Dr. Samuel Johnson (yes) & Wolfgang Amadeus Mozart (may be): Victims of Tourette's syndrome?

    Science.gov (United States)

    Bhattacharyya, Kalyan B; Rai, Saurabh

    2015-01-01

    Tourette's syndrome is a clinical condition characterized by multiple motor tics and vocal tics which occurs in the age range 5-25 years and the intensity of the symptoms changes with time. It is felt that at least two remarkable personalities namely, Dr. Samuel Johnson from England, a man of letters and the compiler of the first ever English dictionary, and Wolfgang Amadeus Mozart from Austria, one of the greatest musical genius of all time, possibly suffered from this condition. Tourette's syndrome is often described as the classical borderzone between neurology and psychiatry and every neurologist wonders at the curious and fascinating clinical features of this condition. It seems that at least two remarkable personalities, Dr. Samuel Johnson, a man of letters and the first person to compile an English dictionary, and Wolfgang Amadeus Mozart, arguably the most creative musical composer of all time, were possibly afflicted with this condition.

  13. Left atrial systolic force in hypertensive patients with left ventricular hypertrophy: the LIFE study

    DEFF Research Database (Denmark)

    Chinali, M.; Simone, G. de; Wachtell, K.

    2008-01-01

    In hypertensive patients without prevalent cardiovascular disease, enhanced left atrial systolic force is associated with left ventricular hypertrophy and increased preload. It also predicts cardiovascular events in a population with high prevalence of obesity. Relations between left atrial...... with larger left ventricular diameter and higher left ventricular mass index (both P hypertrophy was greater (84 vs. 64%; P ..., transmitral peak E velocities and peak A velocities; and lower E/A ratio (all P hypertrophy, but normal left ventricular chamber systolic function with increased...

  14. The multicomponent (2+1)-dimensional Glachette–Johnson (GJ) equation hierarchy and its super-integrable coupling system

    International Nuclear Information System (INIS)

    Yu Fajun; Zhang Hongqing

    2008-01-01

    This paper presents a set of multicomponent matrix Lie algebra, which is used to construct a new loop algebra à M . By using the Tu scheme, a Liouville integrable multicomponent equation hierarchy is generated, which possesses the Hamiltonian structure. As its reduction cases, the multicomponent (2+1)-dimensional Glachette–Johnson (GJ) hierarchy is given. Finally, the super-integrable coupling system of multicomponent (2+1)-dimensional GJ hierarchy is established through enlarging the spectral problem

  15. Interleukin-15 Is Associated with Severity and Mortality in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

    Science.gov (United States)

    Su, Shih-Chi; Mockenhaupt, Maja; Wolkenstein, Pierre; Dunant, Ariane; Le Gouvello, Sabine; Chen, Chun-Bing; Chosidow, Olivier; Valeyrie-Allanore, Laurence; Bellon, Teresa; Sekula, Peggy; Wang, Chuang-Wei; Schumacher, Martin; Kardaun, Sylvia H; Hung, Shuen-Iu; Roujeau, Jean-Claude; Chung, Wen-Hung

    2017-05-01

    Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome/toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in Stevens-Johnson syndrome/TEN. Through screening a panel of 28 serological factors, IL-6, IL-8, IL-15, tumor necrosis factor-α, and granulysin were upregulated in patients with Stevens-Johnson syndrome/TEN and selected for the further validation in total 155 patients with Stevens-Johnson syndrome/TEN, including 77 from Taiwan and 78 from the Registry of Severe Cutaneous Adverse Reactions. Among these factors evaluated, the levels of IL-15 (r = 0.401; P < 0.001) and granulysin (r = 0.223; P = 0.026) were significantly correlated with the disease severity in 112 samples after excluding patients with insufficient data to calculate the score of TEN. In addition, IL-15 was also associated with mortality (P = 0.002; odds ratio, 1.09; 95% confidence interval, 1.03-1.14; P = 0.001; adjusted odds ratio, 1.10; 95% confidence interval, 1.04-1.16). Consistent results were obtained after the exclusion of Taiwanese patients with sepsis to rule out possible confounders. Moreover, IL-15 was shown to enhance cytotoxicity of cultured natural killer cells and blister cells from patients with TEN. Our findings highlight a usefulness of IL-15 in prognosis monitoring and therapeutic intervention of this devastating condition. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy.

    Science.gov (United States)

    Paulmann, Maren; Mockenhaupt, Maja

    2017-05-01

    Fever is a symptom that often accompanies skin eruptions, especially in children. It can be a sign of an infectious condition presenting with exanthems or it may precede an exanthematous eruption. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions affecting skin and mucosa with blisters and erosions. High fever occurs in these conditions, frequently before the skin and/or mucosa is affected.

  17. Clinical, Etiologic, and Histopathologic Features of Stevens-Johnson Syndrome During an 8-Year Period at Mayo Clinic

    Science.gov (United States)

    Wetter, David A.; Camilleri, Michael J.

    2010-01-01

    OBJECTIVE: To examine clinical, etiologic, and histologic features of Stevens-Johnson syndrome and to identify possible correlates of clinical disease severity related to etiologic and histopathologic findings. PATIENTS AND METHODS: This is a retrospective review of patients seen at Mayo Clinic between January 1, 2000, and December 31, 2007. RESULTS: Of 27 patients (mean age, 28.1 years), 22 (81%) had involvement of 2 or more mucous membranes, and 19 (70%) had ocular involvement. Medications, most commonly antibiotics and anticonvulsants, were causative in 20 patients. Mycoplasma pneumoniae infection caused 6 of the 27 cases. Corticosteroids were the most common systemic therapy. No patients with mycoplasma-induced Stevens-Johnson syndrome had internal organ involvement or required treatment in the intensive care unit, in contrast to 4 patients each in the drug-induced group. Three patients had chronic ocular sequelae, and 1 died of complications. Biopsy specimens from 13 patients (48%) showed epidermal necrosis (8 patients), basal vacuolar change (10 patients), and subepidermal bullae (10 patients). Biopsy specimens from 11 patients displayed moderate or dense dermal infiltrate. Histologic features in drug-induced cases included individual necrotic keratinocytes, dense dermal infiltrate, red blood cell extravasation, pigment incontinence, parakeratosis, and substantial eosinophils or neutrophils. CONCLUSION: Our clinical and etiologic findings corroborate those in previous reports. M pneumoniae—induced Stevens-Johnson syndrome manifested less severely than its drug-induced counterpart. The limited number of biopsies precludes unequivocal demonstration of histopathologic differences between drug-induced and M pneumoniae—induced Stevens-Johnson syndrome. PMID:20118388

  18. UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016.

    Science.gov (United States)

    Creamer, D; Walsh, S A; Dziewulski, P; Exton, L S; Lee, H Y; Dart, J K G; Setterfield, J; Bunker, C B; Ardern-Jones, M R; Watson, K M T; Wong, G A E; Philippidou, M; Vercueil, A; Martin, R V; Williams, G; Shah, M; Brown, D; Williams, P; Mohd Mustapa, M F; Smith, C H

    2016-06-01

    The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in adults during the acute phase of the disease. The document aims to. Copyright © 2016 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  19. Noise in the wire: the real impact of wire resistance for the Johnson (-like) noise based secure communicator

    OpenAIRE

    Kish, Laszlo B.; Scheuer, Jacob

    2010-01-01

    We re-evaluate the impact of wire resistance on the noise voltage and current in the Johnson-(like)-noise based secure communicator, correcting the result presented in [Physics Letters A 359 (2006) 737]. The analysis shown here is based on the fluctuation-dissipation and the linear response theorems. The results indicate that the impact of wire resistance in practical communicators is significantly lower than the previous estimation.

  20. A revisited Johnson-Mehl-Avrami-Kolmogorov model and the evolution of grain-size distributions in steel

    OpenAIRE

    Hömberg, D.; Patacchini, F. S.; Sakamoto, K.; Zimmer, J.

    2016-01-01

    The classical Johnson-Mehl-Avrami-Kolmogorov approach for nucleation and growth models of diffusive phase transitions is revisited and applied to model the growth of ferrite in multiphase steels. For the prediction of mechanical properties of such steels, a deeper knowledge of the grain structure is essential. To this end, a Fokker-Planck evolution law for the volume distribution of ferrite grains is developed and shown to exhibit a log-normally distributed solution. Numerical parameter studi...

  1. Stevens-Johnson Syndrome Induced by Carbamazepine Treatment in a Patient Who Previously Had Carbamazepine Induced Pruritus - A Case Report -

    OpenAIRE

    Bae, Hyun Min; Park, Yoo Jung; Kim, Young Hoon; Moon, Dong Eon

    2013-01-01

    Stevens-Johnson syndrome (SJS) is a rare but life-threatening skin reaction disease and carbamazepine is one of its most common causes. We report a case of SJS secondary to carbamazepine in a patient with previous pruritus due to carbamazepine which was given for treatment of trigeminal neuralgia. We would like to caution all providers that carbamazepine readministration should be avoided in the patient with a previous history of SJS or adverse skin reaction. In addition, we strongly recommen...

  2. Stevens - Johnson Syndrome Induced by Combination of Lamotrigine and Valproic Acid in a 9-Year-Old Boy

    LENUS (Irish Health Repository)

    Maduemem, K

    2017-06-01

    We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine. He presented with rash and fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder. SJS happens to be one of the rare adverse reactions of antiepilepsy drugs (AED). Management is mainly supportive with care escalation when necessary because of the significant morbidity.

  3. Noise in the wire: The real impact of wire resistance for the Johnson(-like) noise based secure communicator

    International Nuclear Information System (INIS)

    Kish, Laszlo B.; Scheuer, Jacob

    2010-01-01

    We re-evaluate the impact of wire resistance on the noise voltage and current in the Johnson(-like) noise based secure communicator, correcting the result presented in [J. Scheuer, A. Yariv, Phys. Lett. A 359 (2006) 737]. The analysis shown here is based on the fluctuation-dissipation and the linear response theorems. The results indicate that the impact of wire resistance in practical communicators is significantly lower than the previous estimation.

  4. White Anglo-Saxon hopes and black Americans' Atlantic dreams: Jack Johnson and the British boxing colour bar.

    Science.gov (United States)

    Runstedtler, Theresa

    2010-01-01

    This article examines the controversy surrounding Jack Johnson's proposed world heavyweight title fight against the British champion Bombardier Billy Wells in London (1911). In juxtaposing African Americans' often glowing discussions of European tolerance with the actual white resistance the black champion faced in Britain, including the Home Office's eventual prohibition of the match, the article explores the period's transnational discourses of race and citizenship. Indeed, as white sportsmen on both sides of the Atlantic joined together in their search for a "White Hope" to unseat Johnson, the boxing ring became an important cultural arena for interracial debates over the political and social divisions between white citizens and nonwhite subjects. Although African Americans had high hopes for their hero's European sojourn, the British backlash against the Johnson-Wells match underscored the fact that their local experiences of racial oppression were just one facet of a much broader global problem. At the same time, the proposed prizefight also made the specter of interracial conflict in the colonies all the more tangible in the British capital, provoking public discussions about the merits of U.S. racial segregation, along with the need for white Anglo-Saxon solidarity around the world. Thus, this article not only exposes the underlying connections between American Jim Crow and the racialized fault lines of British imperialism, but it also traces the "tense and tender ties" linking U.S. and African American history with the new imperial history and postcolonial studies.

  5. Quantum electronics. Probing Johnson noise and ballistic transport in normal metals with a single-spin qubit.

    Science.gov (United States)

    Kolkowitz, S; Safira, A; High, A A; Devlin, R C; Choi, S; Unterreithmeier, Q P; Patterson, D; Zibrov, A S; Manucharyan, V E; Park, H; Lukin, M D

    2015-03-06

    Thermally induced electrical currents, known as Johnson noise, cause fluctuating electric and magnetic fields in proximity to a conductor. These fluctuations are intrinsically related to the conductivity of the metal. We use single-spin qubits associated with nitrogen-vacancy centers in diamond to probe Johnson noise in the vicinity of conductive silver films. Measurements of polycrystalline silver films over a range of distances (20 to 200 nanometers) and temperatures (10 to 300 kelvin) are consistent with the classically expected behavior of the magnetic fluctuations. However, we find that Johnson noise is markedly suppressed next to single-crystal films, indicative of a substantial deviation from Ohm's law at length scales below the electron mean free path. Our results are consistent with a generalized model that accounts for the ballistic motion of electrons in the metal, indicating that under the appropriate conditions, nearby electrodes may be used for controlling nanoscale optoelectronic, atomic, and solid-state quantum systems. Copyright © 2015, American Association for the Advancement of Science.

  6. Stevens-Johnson syndrome and toxic epidermal necrolysis-like cutaneous presentation of chikungunya fever: A case series.

    Science.gov (United States)

    Garg, Taru; Sanke, Sarita; Ahmed, Riaz; Chander, Ram; Basu, Srikanta

    2018-03-24

    Chikungunya fever is a benign, self-limiting, acute viral illness. An epidemic occurred in New Delhi, India, in August and September 2016. We observed many cases with atypical cutaneous features mimicking Stevens-Johnson syndrome and toxic epidermal necrolysis during this epidemic, especially in infants and children. Twenty-one children (13 [61.9%] boys, 8 [38%] girls) presenting with vesico-bullous and necrotic lesions were reviewed. Cutaneous presentation included vesicles and bullae with purpuric macules and necrosis, seen in 16 (76%) patients. Skin lesions resolved in 5-7 days, leaving behind hyperpigmentation in seven (33.3%) patients and hypopigmentation in three (14.2%). Minor oral erosions were observed in three (14.2%) patients, and palmoplantar erythema was seen in four (19.04%). It is essential for dermatologists to understand the Stevens-Johnson syndrome and toxic epidermal necrolysis-like presentation of chikungunya and not to misinterpret it as true Stevens-Johnson syndrome and toxic epidermal necrolysis, which will lead to unnecessary intervention and management. © 2018 Wiley Periodicals, Inc.

  7. Qualidade de vida dos pacientes portadores de síndrome de Stevens-Johnson

    Directory of Open Access Journals (Sweden)

    Nogueira Ruth

    2003-01-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida dos pacientes portadores de síndrome de Stevens-Johnson. MÉTODOS: Foram avaliados 14 pacientes com SSJ no período de 1998 e 1999 no Setor de Córnea do Departamento de Oftalmologia da UNIFESP. Empregou-se o questionário S. F. 36 - pesquisa em saúde. A pontuação indica melhor condição de saúde. A mesma avaliação foi repetida quatro vezes em intervalo de três meses. RESULTADOS: As médias das médias das 4 avaliações dos 14 pacientes apresentaram importante redução dos seus valores em todos os subitens do S.F. 36 (41,04±22,38 para aspectos físicos, 53,82±22,82 para aspectos sociais, 26,24±22,46 para aspectos emocionais, 34,95±25,45 para capacidade funcional, 42,03±31,85 para dor, 46,33±18,37 para vitalidade, 46,18±24,83 para saúde mental e 50,26±16,29 para saúde geral. CONCLUSÃO: O questionário S.F. 36 representa método adequado de avaliação de aspectos físicos e emocionais em pacientes com baixa de acuidade visual, que nos permitiu detectar comprometimento importante nas funções básicas dos pacientes com SSJ. Mais pacientes com maior tempo de seguimento são necessários para aprimorar a análise de qualidade de vida nesses pacientes e avaliar os efeitos do acompanhamento psicológico.

  8. Random-Resistor-Random-Temperature Kirchhoff-Law-Johnson-Noise (RRRT-KLJN Key Exchange

    Directory of Open Access Journals (Sweden)

    Kish Laszlo B.

    2016-03-01

    Full Text Available We introduce two new Kirchhoff-law-Johnson-noise (KLJN secure key distribution schemes which are generalizations of the original KLJN scheme. The first of these, the Random-Resistor (RR- KLJN scheme, uses random resistors with values chosen from a quasi-continuum set. It is well-known since the creation of the KLJN concept that such a system could work in cryptography, because Alice and Bob can calculate the unknown resistance value from measurements, but the RR-KLJN system has not been addressed in prior publications since it was considered impractical. The reason for discussing it now is the second scheme, the Random Resistor Random Temperature (RRRT- KLJN key exchange, inspired by a recent paper of Vadai, Mingesz and Gingl, wherein security was shown to be maintained at non-zero power flow. In the RRRT-KLJN secure key exchange scheme, both the resistances and their temperatures are continuum random variables. We prove that the security of the RRRT-KLJN scheme can prevail at a non-zero power flow, and thus the physical law guaranteeing security is not the Second Law of Thermodynamics but the Fluctuation-Dissipation Theorem. Alice and Bob know their own resistances and temperatures and can calculate the resistance and temperature values at the other end of the communication channel from measured voltage, current and power-flow data in the wire. However, Eve cannot determine these values because, for her, there are four unknown quantities while she can set up only three equations. The RRRT-KLJN scheme has several advantages and makes all former attacks on the KLJN scheme invalid or incomplete.

  9. Topical Treatment for Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis: A Review

    Directory of Open Access Journals (Sweden)

    Schandra Purnamawati

    2016-08-01

    Full Text Available Background: Stevens - Johnson syndrome (SJS and Toxic Epidermal Necrolysis (TEN are currently regarded to be same disease entity which differs only in the extent and severity of epidermal sloughing. Both are potentially life-threatening mucocutaneous immunologic reaction, which are most frequently induced by drug consumption. The epithelial destruction of skin and mucosal membrane can cause both acute as well as chronic/ long term outcomes in term of  late sequelae during the course of the disease. Sequelae often occur during the late phase of SJS/TEN and become a significant problem due its chronicity and severe degree of impairment, which leads to deterioration of quality of life for the patients. This may prevented or decreased in terms of intensity if the patient’s received prompt and sufficient topical therapy, particularly in managing lesions on the mucosa of the eye, oral, and genital. Objective : This review underlines topical therapies which could be delivered for management of mucocutaneous lesions from SJS/ TEN, aimed to prevent late sequelae due to SJS – TEN in order to improve the life quality of SJS – TEN survivors. Conclusion: SJS/ TEN frequently lead to late sequeale which includes skin, ocular, oral, and genital involvement. These sequelaes are often severe and chonic. Thus, may cause significant decrease in quality of life of SJS/TEN survivors. It is therefore most important to detect them early in order to manage them adequately. To date, we still have an impression that the specific sequelae of SJS – TEN are often late diagnosed and insufficiently treated. Finally, we want to emphasize that for mucosal involvement in particular, such as ocular, genital and oral involvement, a careful topical treatment have to be taken into special consideration in order to prevent severe late sequelae. 

  10. Initial evaluation of the Robert Wood Johnson Foundation Nurse Faculty Scholars program.

    Science.gov (United States)

    Hickey, Kathleen T; Hodges, Eric A; Thomas, Tami L; Coffman, Maren J; Taylor-Piliae, Ruth E; Johnson-Mallard, Versie M; Goodman, Janice H; Jones, Randy A; Kuntz, Sandra; Galik, Elizabeth; Gates, Michael G; Casida, Jesus M

    2014-01-01

    The Robert Wood Johnson Foundation Nurse Faculty Scholars (RWJF NFS) program was developed to enhance the career trajectory of young nursing faculty and to train the next generation of nurse scholars. Although there are publications that describe the RWJF NFS, no evaluative reports have been published. The purpose of this study was to evaluate the first three cohorts (n = 42 scholars) of the RWJF NFS program. A descriptive research design was used. Data were derived from quarterly and annual reports, and a questionnaire (seven open-ended questions) was administered via Survey Monkey Inc. (Palo Alto, CA, USA). During their tenure, scholars had on average six to seven articles published, were teaching/mentoring at the graduate level (93%), and holding leadership positions at their academic institutions (100%). Eleven scholars (26%) achieved fellowship in the American Academy of Nursing, one of the highest nursing honors. The average ratings on a Likert scale of 1 (not at all supportive) to 10 (extremely supportive) of whether or not RWJF had helped scholars achieve their goals in teaching, service, research, and leadership were 7.7, 8.0, 9.4, and 9.5, respectively. The majority of scholars reported a positive, supportive relationship with their primary nursing and research mentors; although, several scholars noted challenges in connecting for meetings or telephone calls with their national nursing mentors. These initial results of the RWJF NFS program highlight the success of the program in meeting its overall goal-preparing the next generation of nursing academic scholars for leadership in the profession. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Band gaps from the Tran-Blaha modified Becke-Johnson approach: A systematic investigation

    Science.gov (United States)

    Jiang, Hong

    2013-04-01

    The semi-local Becke-Johnson (BJ) exchange-correlation potential and its modified form proposed by Tran and Blaha (TB-mBJ) have attracted a lot of interest recently because of the surprisingly accurate band gaps they can deliver for many semiconductors and insulators. In this work, we have investigated the performance of the TB-mBJ potential for the description of electronic band structures in a comprehensive set of semiconductors and insulators. We point out that a perturbative use of the TB-mBJ potential can give overall better results. By investigating a set of IIB-VI and III-V semiconductors, we point out that although the TB-mBJ approach can describe the band gap of these materials quite well, the binding energies of semi-core d-states in these materials deviate strongly from experiment. The difficulty of the TB-mBJ potential to describe the localized states is likely the cause for the fact that the electronic band structures of Cu2O and La2O3 are still poorly described. Based on these observations, we propose to combine the TB-mBJ approach with the Hubbard U correction for localized d/f states, which is able to provide overall good descriptions for both the band gaps and semi-core states binding energies. We further apply the approach to calculate the band gaps of a set of Ti(IV)-oxides, many of which have complicated structures so that the more advanced methods like GW are expensive to treat directly. An overall good agreement with experiment is obtained, which is remarkable considering its little computational efforts compared to GW.

  12. Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis.

    Science.gov (United States)

    Micozzi, Sarah; Perez-Ezquerra, Patricia Rojas; Morales-Cabeza, Cristina; Diez, Cristina; De Barrio, Manuel

    2017-01-01

    HIV positive patients can suffer many complications due to infectious diseases. A sever drug reaction to some of the drugs involved in the treatment can overlap the symptoms of the infections, making the diagnosis very difficult. We present the case of a 28-year-old-man, HIV positive, with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he received. The SJS was overlapped with a possible Jarisch Herxheimer Reaction, which complicated the diagnosis of the skin reaction. In HIV+ patients, the overlapping of severe drug reactions and infectious diseases could be fatal, thus an accurate diagnosis is mandatory. A Rapid Plasma Reagin Test (RPR), an ELISA test, a blood laboratory test, chest radiography and a skin biopsy were realized in order to diagnose the infectious disease and the cause of skin lesions. Intradermal tests and double blind challenge tests were realized in the allergy study. The laboratory tests confirmed the diagnosis of syphilis; the skin biopsy confirmed the cause of lesions, a severe allergic reaction as a SJS. The allergy study discharged all the drugs involved, except dypirone which wasn't proved in the study because of the severity of reaction, the high possibility to be the causative drug and the alternative of other similar drugs available. For the inflammatory response, HIV+ patients are especially susceptible to severe reaction, both infectious and allergic, as in this case. Thus, recent patents emphasize the interest in inflammatory molecules that cause inflammatory symptoms. Although the diagnose of SJS has established criteria, the possibility of overlapping with infectious illness and/or with its treatment, may complicate the diagnosis. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  13. Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis

    Science.gov (United States)

    CHANTAPHAKUL, HIROSHI; SANON, THANOMSAK; KLAEWSONGKRAM, JETTANONG

    2015-01-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are erythematous skin lesions with blister formation accompanied by mucosal involvement. These conditions are considered to be life-threatening illnesses. Understanding the clinical presentation, risk factors, treatment options and results will be advantageous for physicians in the management of patients in the future. The aim of the present study was to review and analyze the clinical manifestations, drug implications, treatment and outcome of patients with SJS and/or TEN who had been hospitalized in a tertiary care center. All hospitalized patients with SJS and/or TEN during a 5-year period were retrospectively reviewed. The clinical severity was graded according to the score of toxic epidermal necrolysis (SCORTEN) scale. Clinical symptoms, diagnosis, possible precipitating factors, management and outcome data were collected for analysis. A total of 43 patients (mean age, 49.5 years) were hospitalized and classified into the SJS group (55.8%), SJS/TEN overlap group (20.9%) and TEN group (23.3%). The majority of the patients (90.7%) had mucocutaneous eruptions associated with oral drug administration. Allopurinol, anticonvulsants and antibiotics were the most common causative agents for the mucocutaneous eruption. Twenty-eight patients (65.1%) were treated with corticosteroids. The mortality rate was 6.9%. Comparison between the survival group and the non-survival group revealed that patient age >70 years (P=0.014) and body surface area involvement >20% (P<0.01) were the significant factors associated with mortality. The use of systemic steroids was higher in the survival group in comparison with the non-survival group (65.1 vs. 0%, respectively; P=0.014). The mucocutaneous eruptions in SJS and TEN are mostly caused by medication. With early recognition and treatment, the mortality rate in this study was lower than that in previous reports. Patient age and the area of mucocutaneous involvement

  14. Retrospective Analysis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in 88 Chinese Patients.

    Science.gov (United States)

    Wang, Li; Mei, Xue-Ling

    2017-05-05

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases with high mortality rates. This study was designed to analyze the pathogenic factors, clinical manifestations, complications, treatment, and prognosis of SJS/TEN and to explore the differences between surviving and deceased patients. SJS/TEN patients admitted to Beijing Friendship Hospital from January 2006 to December 2015 were included in the study. Patients' data were retrospectively analyzed. Comparative studies were performed on the survival group and the deceased group, and Fisher's exact probability test was used for statistical analysis. Among the 88 patients included, 40 (45.5%) were male with a mean age of 45 ± 18 years. Forty-eight (54.5%) had SJS, 34 (38.6%) had SJS/TEN, and 6 (6.8%) had TEN. Fifty-three (60.2%) cases were caused by medications, mainly antibiotics (n = 24) followed by traditional Chinese medicines (n = 7). Forty-two cases (47.7%) developed visceral damage. Eighty-two patients improved or recovered and were discharged from hospital, and six patients died. Comparative studies on the survival group and the deceased group showed that the presence of malignant tumor ( χ2 = 27.969,P 100 times/min ( χ2 = 6.347, P= 0.012), detached skin area >20% ( χ2 = 5.594, P= 0.018), concurrent mucosal involvement at the mouth, eyes, and external genitals ( χ2 = 4.945, P= 0.026), subsequent accompanying liver/kidney damage ( χ2 = 11.839, P= 0.001, and χ2 = 36.302,P 2 ( χ2 = 37.148,P < 0.001) increased the risk of death. SJS/TEN is mainly caused by medications, and nearly half of patients develop visceral damage. Multiple factors increase the mortality risk.

  15. Ocular Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children.

    Science.gov (United States)

    Catt, Caroline J; Hamilton, Gavin M; Fish, Joel; Mireskandari, Kamiar; Ali, Asim

    2016-06-01

    To describe the acute and chronic ocular manifestations of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN Overlap syndrome (Overlap syndrome) in children. Retrospective case series. Medical records of children admitted to the Hospital for Sick Children between 2001 and 2011 with SJS, TEN, and Overlap syndrome were reviewed. Demographic information, all abnormal ophthalmic findings (and median time to first diagnosis), visual acuities, and ophthalmic treatments prescribed were collected for each eye for every patient. Thirty-six children were identified for inclusion in the study. Twenty-nine (81%) had acute ocular involvement, including all patients with TEN (n = 7). Conjunctivitis was the most common (78%) clinical sign. This, together with conjunctival membranes and subconjunctival hemorrhage, were the earliest signs, presenting by a median of 1 day. The percentage of patients and median time to occurrence of complications were as follows: for lid margin ulceration and corneal epithelial defects, 25%, 3 days; conjunctival ulceration, 39%, 3.5 days; symblepharon, 28%, 4 weeks; corneal opacification, 11%, 4 months; limbal stem cell failure, 8%, 7 months; and corneal vascularisation, 8%, 10 months after admission. Over 90% of children maintain a visual acuity of 20/40 or better in each eye at a mean follow-up of 1.4 years. Ocular involvement in SJS, TEN, and Overlap syndrome is common and the ocular manifestations may develop many months after the initial presentation, mandating the need for long-term follow-up of these children. Despite the high frequency of sight-threatening disease, most children maintain good vision in the long term. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. New Grading System and Treatment Guidelines for the Acute Ocular Manifestations of Stevens-Johnson Syndrome.

    Science.gov (United States)

    Gregory, Darren G

    2016-08-01

    To describe a new grading system and associated treatment guidelines for the acute ocular manifestations of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Prospective case series. Seventy-nine consecutive patients (158 eyes) evaluated and treated for acute ocular involvement in SJS or TEN during hospitalization. Photographic and chart review of acute ocular findings, interventions received, and outcomes with regard to visual acuity, dry eye symptoms, and scarring sequelae at least 3 months after the acute illness. Visual acuity, dry eye severity, and scarring of the ocular surface and eyelids were assessed after follow-up of at least 3 months. Cases graded as mild or moderate were managed medically. All had best-corrected visual acuity (BCVA) of 20/20, no dry eye symptoms, and no scarring sequelae. Cases graded as severe or extremely severe were treated with urgent amniotic membrane transplantation (AMT) in addition to medical management. Severe cases all had BCVA of 20/20 and mild or no dry eye problems. Five of 28 patients had mild tarsal conjunctival scarring. No other scarring sequelae occurred. Nine of the 10 extremely severe cases had BCVA of 20/20 (1 was 20/30). Three of 10 had moderate scarring of the tarsal conjunctiva and lid margins and also moderate dry eyes with severe photophobia. Seven of 10 had only mild or no dry eye symptoms and scarring sequelae. This grading system facilitates decision making in the evaluation and management of the acute ocular manifestations of SJS and TEN. Mild and moderate cases have a low risk of significant scarring or visual sequelae and may be monitored and treated medically if not worsening. Severe and extremely severe cases should receive urgent AMT to decrease the risk of scarring and visual sequelae. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  17. A retrospective analysis of Stevens-Johnson syndrome/toxic epidermal necrolysis treated with corticosteroids.

    Science.gov (United States)

    Liu, Wenmin; Nie, Xiaojuan; Zhang, Li

    2016-12-01

    Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe mucocutaneous reactions that incur high mortality, and in which the systemic application of corticosteroids remains controversial. This study aimed to determine the optimal protocols for the use of corticosteroids and treatment measures. We performed a retrospective analysis of 70 patients with SJS/TEN who were hospitalized between January 2008 and May 2015 in the Department of Dermatology, Shandong Provincial Hospital, and treated with corticosteroids. Expected and actual mortality rates in patients treated with different doses of corticosteroids, according to SCORTEN, were compared. The diagnoses associated with initial corticosteroid use differed significantly between the low- and high-dose groups (P = 0.041). There were significant differences between expected and actual mortality rates according to the use of corticosteroid therapy (P = 0.0168, standardized mortality ratio [SMR] = 0.30). There was a statistical difference between expected and actual mortality rates in the low-dose group (P = 0.0145, SMR = 0.20). Serum albumin levels were significantly lower in patients administered corticosteroids additive therapy (31.12 ± 8.32 g/l vs. 35.54 ± 5.82 g/l; P = 0.016), and the rate of use of antibiotics was higher among patients in the additive therapy group than in the non-additive group (94.7% vs. 60.8%). Our research supports the use of corticosteroids for the systemic treatment of SJS/TEN. Corticosteroids should be used in a timely manner and in accordance with disease severity, age, underlying diseases, serum albumin level, and concurrent treatment with antimicrobial therapy. © 2016 The International Society of Dermatology.

  18. Stevens-johnson syndrome associated with drugs and vaccines in children: a case-control study.

    Directory of Open Access Journals (Sweden)

    Umberto Raucci

    Full Text Available OBJECTIVE: Stevens-Johnson Syndrome (SJS is one of the most severe muco-cutaneous diseases and its occurrence is often attributed to drug use. The aim of the present study is to quantify the risk of SJS in association with drug and vaccine use in children. METHODS: A multicenter surveillance of children hospitalized through the emergency departments for acute conditions of interest is currently ongoing in Italy. Cases with a diagnosis of SJS were retrieved from all admissions. Parents were interviewed on child's use of drugs and vaccines preceding the onset of symptoms that led to the hospitalization. We compared the use of drugs and vaccines in cases with the corresponding use in a control group of children hospitalized for acute neurological conditions. RESULTS: Twenty-nine children with a diagnosis of SJS and 1,362 with neurological disorders were hospitalized between 1(st November 1999 and 31(st October 2012. Cases were more frequently exposed to drugs (79% vs 58% in the control group; adjusted OR 2.4; 95% CI 1.0-6.1. Anticonvulsants presented the highest adjusted OR: 26.8 (95% CI 8.4-86.0. Significantly elevated risks were also estimated for antibiotics use (adjusted OR 3.3; 95% CI 1.5-7.2, corticosteroids (adjusted OR 4.2; 95% CI 1.8-9.9 and paracetamol (adjusted OR 3.2; 95% CI 1.5-6.9. No increased risk was estimated for vaccines (adjusted OR: 0.9; 95% CI 0.3-2.8. DISCUSSION: Our study provides additional evidence on the etiologic role of drugs and vaccines in the occurrence of SJS in children.

  19. Use of Video Directly Observed Therapy for Treatment of Latent Tuberculosis Infection - Johnson County, Kansas, 2015.

    Science.gov (United States)

    Holzschuh, Elizabeth Lawlor; Province, Stacie; Johnson, Krystle; Walls, Caitlin; Shemwell, Cathy; Martin, Gary; Showalter, Amy; Dunlay, Jennifer; Conyers, Andrew; Griffin, Phil; Tausz, Nancy

    2017-04-14

    Tuberculosis (TB) is caused by the bacterium Mycobacterium tuberculosis and is spread from person to person through the air. TB can be spread in congregate settings, such as school environments, to varying degrees, based on factors including duration of contact and air ventilation (1); therefore, evaluating potential contacts and exposures can be challenging. In February 2015, a student at a Kansas high school received a diagnosis of active pulmonary TB disease. Screening of 385 (91%) school contacts, four (100%) household contacts, and 19 (90%) social contacts resulted in the identification of 50 persons with latent TB infection. Johnson County Department of Health and Environment (JCDHE) Public Health Emergency Preparedness personnel used their experience with points of distribution logistics to optimize testing clinic layouts and implement the incident command structure. Open communication with students, school staff members, the public, and the media about the investigation from the outset was imperative to reduce rumors and unease that can accompany a large communicable disease investigation. The large number of persons needing treatment for latent TB overwhelmed JCDHE's two TB nurses. As a result, JCDHE developed a policy and procedure to allow persons who met eligibility requirements to complete 12 weekly doses of isoniazid and rifapentine treatment using video directly observed therapy (VDOT) rather than traditional in-person directly observed therapy (DOT). This procedure facilitated treatment compliance and completion; among the eligible 15 persons who chose the 12-week VDOT option, 14 (93%) completed treatment. State and local health departments might consider use of VDOT to monitor treatment of persons with latent TB infection.

  20. Johnson Space Center Research and Technology Annual Report 1998-1999

    Science.gov (United States)

    Abbey, George W. S.

    2004-01-01

    As the principle center for NASA's Human Exploration and Development of Space (HEDS) Enterprise, the Johnson Space Center (JSC) leads NASA development of human spacecraft, human support systems, and human spacecraft operations. An important element in implementing this mission, JSC has focused on developing the infrastructure and partnerships that enable the technology development for future NASA programs. In our efforts to develop key technologies, we have found that collaborative relationships with private industry and academia strengthen our capabilities, infuse innovative ideas, and provide alternative applications for our development projects. The American public has entrusted NASA with the responsibility for space technology development, and JSC is committed to the transfer of the technologies that we develop to the private sector for further development and application. It is our belief that commercialization of NASA technologies benefits both American industry and NASA through technology innovation and continued partnering. To this end, we present the 1998-1999 JSC Research and Technology Report. As your guide to the current JSC technologies, this report showcases the projects in work at JSC that may be of interest to U.S. industry, academia, and other government agencies (federal, state, and local). For each project, potential alternative uses and commercial applications are described. To aid in your search, projects are arranged according to the Major Product Groups used by CorpTech to classify and index types of industry. Some projects fall into multiple categories and are placed under the predominant category, for example, an artificial intelligence project is listed under the Computer Software category, while its function is to automate a process (Automation category).

  1. Draft environmental statement. Wyoming Mineral Corporation, Irigaray solution mining project (Johnson County, Wyoming)

    International Nuclear Information System (INIS)

    1978-04-01

    The Irigaray project consists of solution mining (in situ leaching) operations involving uranium ore deposits in Johnson County, Wyoming. Solution mining activities will include a processing facility with an annual production of 500,000 lb of U 3 O 8 from up to 50 acres of well fields through the initial license authorization. The Irigaray project has an estimated lifetime of 10 to 20 years with known ore deposits and the current level of solution mining technology. Environmental impacts and adverse effects are summarized. The site is mostly used as grazing land for cattle and sheep. Initiation of the Irigaray project would result in the temporary removal from grazing and the disturbance of approximately 60 acres during operation. All disturbed surface areas will be reclaimed and returned to their original use. Approximately 1.2 x 10 6 m 3 (1000 acre-ft) of water will be withdrawn from the ore zone aquifer. This water will be conveyed to the onsite waste ponds for evaporation. An estimated 4.2 x 10 5 m 3 (340 acre-ft) of groundwater is expected to temporarily contain increased concentrations of radioactive and toxic elements during the operation of each 4-ha (10-acre) well field. Restoration should return this water to a condition that is consistent with its premining use (or potential use). There will be no discharge of liquid effluents from the Irigaray project. Atmospheric effluents will be within acceptable limits. The dose rates of radionuclides in the air at the nearest ranches from the plant site are tabulated. The Irigaray project proposes the production and utilization of 500,000 lb per year of uranium resources. The Irigaray project will not produce any significant socioeconomic impact on the local area because of the small number of employees that will be employed at the project

  2. Spectral model selection in the electronic measurement of the Boltzmann constant by Johnson noise thermometry

    Science.gov (United States)

    Coakley, Kevin J.; Qu, Jifeng

    2017-04-01

    In the electronic measurement of the Boltzmann constant based on Johnson noise thermometry, the ratio of the power spectral densities of thermal noise across a resistor at the triple point of water, and pseudo-random noise synthetically generated by a quantum-accurate voltage-noise source is constant to within 1 part in a billion for frequencies up to 1 GHz. Given knowledge of this ratio, and the values of other parameters that are known or measured, one can determine the Boltzmann constant. Due, in part, to mismatch between transmission lines, the experimental ratio spectrum varies with frequency. We model this spectrum as an even polynomial function of frequency where the constant term in the polynomial determines the Boltzmann constant. When determining this constant (offset) from experimental data, the assumed complexity of the ratio spectrum model and the maximum frequency analyzed (fitting bandwidth) dramatically affects results. Here, we select the complexity of the model by cross-validation—a data-driven statistical learning method. For each of many fitting bandwidths, we determine the component of uncertainty of the offset term that accounts for random and systematic effects associated with imperfect knowledge of model complexity. We select the fitting bandwidth that minimizes this uncertainty. In the most recent measurement of the Boltzmann constant, results were determined, in part, by application of an earlier version of the method described here. Here, we extend the earlier analysis by considering a broader range of fitting bandwidths and quantify an additional component of uncertainty that accounts for imperfect performance of our fitting bandwidth selection method. For idealized simulated data with additive noise similar to experimental data, our method correctly selects the true complexity of the ratio spectrum model for all cases considered. A new analysis of data from the recent experiment yields evidence for a temporal trend in the offset

  3. Left Paraduodenal Hernia: An Autopsy Case

    DEFF Research Database (Denmark)

    Omland, Silje Haukali; Hougen, Hans Petter

    2011-01-01

    We present a case of a left paraduodenal hernia diagnosed at autopsy. A left paraduodenal hernia is an internal hernia of congenital origin due to the abnormal rotation of the midgut during embryonic development. Internal hernias are a rare cause of intestinal obstruction, with the paraduodenal...

  4. Malignant phyllodes tumor of the left atrium

    Directory of Open Access Journals (Sweden)

    Anupam Bhambhani

    2014-03-01

    Full Text Available Metastatic tumors to the heart usually involve right sided chambers. We report a rare case of malignant phyllodes tumor of breast with metastatic involvement of left atrium occurring through direct invasion from mediastinal micro-metastasis and presenting as a left atrial mass causing arrhythmia.

  5. Left ventricular hypertrophy, geometric patterns and clinical ...

    African Journals Online (AJOL)

    Background: Left ventricular hypertrophy can be due to various reasons including hypertension. It constitutes an increased cardiovascular risk. Various left ventricular geometric patterns occur in hypertension and may affect the cardiovascular risk profile of hypertensive subjects. Methods: One hundred and eighty eight ...

  6. Leptogenesis with left-right domain walls

    Indian Academy of Sciences (India)

    the scale of left-right symmetry breaking. Keywords. Leptogenesis; baryogenesis; domain walls; left-right symmetry. PACS Nos 12.10.Dm; 98.80.Cq; 98.80.Ft. Explaining the observed baryon asymmetry of the Universe within the framework of gauge theories and the standard Big Bang cosmology remains an open problem.

  7. On establishing coreference in Left Dislocation constructions ...

    African Journals Online (AJOL)

    The phenomenon of left dislocation (LD) has received relatively little attention in the generative literature. In Government & Binding theory and early versions of Minimalist Syntax, the left-dislocated expression is conventionally taken to be base-generated in its sentence-initial surface position and the resumptive pronoun in ...

  8. A new clinical sign probably associated to left hemiplegia with left hemineglect syndrome: the crossed legs.

    Science.gov (United States)

    Bazan, Rodrigo; Fernandes, Thiago; Braga, Gabriel; Luvizutto, Gustavo; Resende, Luiz

    2014-06-01

    To describe a new clinical sign associated with left unilateral neglect syndrome (UNS) in patients with ischemic stroke. Head computed tomography (CT) and National Institute of Health Stroke Scale were obtained in 150 patients with ischemic stroke. Those with right cerebral vascular lesions, left hemiplegia and right leg persistently crossed over the left were submitted to specific tests for UNS. The tests were also applied to 30 patients with right cerebral vascular lesions, left hemiplegia but without crossed legs. From 9 patients with persistent tendency to cross the right leg over the left, UNS was detected in 8. One patient died before the clinical tests were applied. Of the 30 patients without the crossed legs, 20 had normal clinical tests for UNS and 10 had minimal alterations, not sufficient for the diagnosis of UNS. The right leg crossed over the left may represent a new neurological semiotic sign associated with left hemiplegia and left UNS.

  9. VARIATION IN THE OPENINGS (OSTIA OF LEFT PULMONARY VEINS INTO THE LEFT ATRIUM: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sesi

    2015-03-01

    Full Text Available During early embryonic development, absorption of pulmonary venous network by the left primitive atrial chamber results in opening of four pulmonary veins which drain independently into its chamber. The extent of absorption and hence, the number of pulmon ary veins which open into the left atrium, may vary. Here we report a variation in the opening of the Left upper (superior pulmonary vein into the Left atrium. A total of six openings observed

  10. Ühendkuningriigi parlamendi alamkoja Euroopa asjade komisjoni esimehe hr Jimmy Hood'i sõnavõtt / Jimmy Hood

    Index Scriptorium Estoniae

    Hood, Jimmy

    2003-01-01

    Ilmunud ka: Proceedings of the 9th international conference "Estonia and the European Union: Estonia on its way to a changing Europe" : October 30-November 1, 2002, Tallinn, Estonian National Library. - Tallinn, lk. 40-42. Autori kõne paneelistungil "Parlamentaarse kontrolli efektiivsus vs demokraatia"

  11. Social aspects of left-handedness

    Directory of Open Access Journals (Sweden)

    Belojević Goran

    2010-01-01

    Full Text Available Throughout human history left-handedness has been considered as sinful. It has been associated with the devil, weakness, female gender, unhealthiness, evil, something that has to be turned to a “good” - right side by force. Left-handedness is being more and more acceptable at rational level, but in everyday life it is still considered to be unusual if someone writes with the left hand. Lessening of the number of lefthanders is associated with ageing. There are about 13% lefthanders among people in twenties and less than 1% lefthanders among those in eighties. This finding may be explaned with more pronounced socio-cultural pressure on left-handed people in the past, compared to nowadays. On the other hand, this may also support the hypothesis about a reduced life span of lefthanded people. With cross-exercising of left-handedness, certain typical characteristics and behavioral patterns appear in these people. This was a sort of provoked behavior and an attack on the integrity of an emotional attitude toward oneself. Stuttering may also appear as a consequence of unsuccessful cross-exercising of left-handedness. The hypothesis about left-handedness as an advantage is supported with the reports about relatively more lefthanders in some specific groups such as: mathematicians, sculptors, architects, painters, musicians, actors, tennis players, as well as famous army commanders and rulers.

  12. Left ventricular performance during triggered left ventricular pacing in patients with cardiac resynchronization therapy and left bundle branch block

    DEFF Research Database (Denmark)

    Witt, Christoffer Tobias; Kronborg, Mads Brix; Nohr, Ellen Aagaard

    2016-01-01

    PURPOSE: To assess the acute effect of triggered left ventricular pacing (tLVp) on left ventricular performance and contraction pattern in patients with heart failure, left bundle branch block (LBBB), and cardiac resynchronization therapy (CRT). METHODS: Twenty-three patients with pre-implant QRS...... complex >150 ms, QRS complex narrowing under CRT, and sinus rhythm were included ≥3 months after CRT implantation. Echocardiographic assessment of left ventricular ejection fraction (LVEF), global peak systolic longitudinal strain (GLS), and contraction pattern by 2D strain was performed during intrinsic......V pacing. CONCLUSIONS: The acute effect of tLVp on LV systolic function and contraction pattern is significantly lower than the effect of BiV pacing and not different from intrinsic conduction in patients with LBBB and CRT....

  13. [Vectorcardiographic manifestations of left intraventricular conduction disorders].

    Science.gov (United States)

    de Micheli, A; Medrano, G A

    1979-01-01

    Both, the vectorcardiographic changes produced by the various degrees of left bundle branch block and these observed with the different types of left distal block, are described. When a "wave jumping" phenomenon exists, the vectorcardiographic changes are more characteristic in the horizontal plane than in the frontal plane and can be interpreted satisfactorily in basis of the ventricular activation sequence. The normal counterclockwise rotation of the horizontal vectorcardiogram persists in the presence of left bundle branch block of slight and moderate degrees, since the electromotive forces of the free left ventricular wall are still predominant. In the majority of intermediate degree blocks, the middle portion of the RH loop develops with a clockwise rotation and general aspect with a clockwise rotation and the general aspect of the ventricular loop resembles an eight figure. This is due to the electromotive forces originated by the delayed depolarization of the left septal mass that starts to predominate. With advanced degrees of block, the largest portion of the RH loop shows a clockwise rotation, as well as marked notchings and slurrings. The initial anterior portion of the horizontal vectorcardiogram does not disappear, but is situated to the left of the anterior-posterior axis with a counterclockwise rotation (first right septal vector). Otherwise, the direct electrical sign of left distal block emphasized: evidence of delayed activation in a limited zone of the homolateral ventricle. This local delay gives rise to an asynchronism of the activation phenomenon between the upper and lower regions of the ventricle. The diagnosis of left bifascicular block is based essentially on the evidence of unequal delay of the activation sequence in the basal regions and in the inferior ones of the homolateral ventricle and also on the frequent persistence of the first left septal vector.

  14. Uncertainty from synergistic effects of multiple parameters in the Johnson and Ettinger (1991) vapor intrusion model

    Science.gov (United States)

    Tillman, Fred D.; Weaver, James W.

    Migration of volatile chemicals from the subsurface into overlying buildings is known as vapor intrusion (VI). Under certain circumstances, people living in homes above contaminated soil or ground water may be exposed to harmful levels of these vapors. VI is a particularly difficult pathway to assess, as challenges exist in delineating subsurface contributions to measured indoor-air concentrations as well as in adequate characterization of subsurface parameters necessary to calibrate a predictive flow and transport model. Often, a screening-level model is employed to determine if a potential indoor inhalation exposure pathway exists and, if such a pathway is complete, whether long-term exposure increases the occupants' risk for cancer or other toxic effects to an unacceptable level. A popular screening-level algorithm currently in wide use in the United States, Canada and the UK for making such determinations is the "Johnson and Ettinger" (J&E) model. Concern exists over using the J&E model for deciding whether or not further action is necessary at sites as many parameters are not routinely measured (or are un-measurable). Many screening decisions are then made based on simulations using "best estimate" look-up parameter values. While research exists on the sensitivity of the J&E model to individual parameter uncertainty, little published information is available on the combined effects of multiple uncertain parameters and their effect on screening decisions. This paper presents results of multiple-parameter uncertainty analyses using the J&E model to evaluate risk to humans from VI. Software was developed to produce automated uncertainty analyses of the model. Results indicate an increase in predicted cancer risk from multiple-parameter uncertainty by nearly a factor of 10 compared with single-parameter uncertainty. Additionally, a positive skew in model response to variation of some parameters was noted for both single and multiple parameter uncertainty analyses

  15. Steven Johnson Syndrome and Toxic Epidermal Necrolysis in a burn unit: A 15-year experience.

    Science.gov (United States)

    McCullough, M; Burg, M; Lin, E; Peng, D; Garner, W

    2017-02-01

    The diffuse epidermal exfoliation seen in Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) is similar to skin loss in second degree burns, and many of these patients are referred for treatment at burn centers. Treatment can differ markedly from center to center, and mortality can range from 25% to 70%, including a considerable morbidity. However, our experience over a 15-year period from 2000 to 2015 with 40 patients found a mortality rate of only 10% (4/40). The purpose of this paper is to discuss our treatment algorithm as a model for other centers treating SJS/TENs patients. Records were reviewed for all patients admitted to the LAC+USC burn unit between 2000 and 2015 and 40 patients were identified with biopsy-proven SJS or TENS. These cases were reviewed for age, gender, initial and greatest TBSA, causative drug, pre-existing medical conditions, and morbidity and mortality. All data were entered into the SPSS statistical software package and all statistical analyses were performed using this program. Our treatment algorithm focused on early referral to a specialty burn unit, immediate discontinuation of the offending drug, fluid resuscitation, nutritional supplementation, and meticulous wound care. Average time to transfer to a burn unit was 3.36 days. Silver-releasing antimicrobial dressings were applied to the affected skin surface and changed every 3 days. Mupirocin coated petroleum gauze was used for facial involvement. Steroids were tapered and discontinued if initiated at an outside facility (58% of patients), and starting after 2001, all patients received a course of IVIG. All patients received fluid resuscitation and the majority received supplemental tube feedings (69%). Average length of total stay was 17.1 days and length of ICU stay 15.9 days. While 44% were transferred to another facility for further rehabilitative care, 37% of patients discharge to home. In patients discharged home with complete resolution of skin lesions, time

  16. Grouting of the cracks in the Arch 5-6 Daniel Johnson dam

    International Nuclear Information System (INIS)

    Lariviere, R.; Routhier, L.; Roy, V.; Saleh, K.; Tremblay, S.

    1999-01-01

    The Daniel-Johnson dam is located 800 km northeast of Montreal, PQ, and is 1314 m in length and 214 m high. Just after completion of dam construction different types of cracks started to appear on the upstream and downstream faces. During and after the construction of the dam, numerous cracks and joints were grouted in order to reduce water infiltration. In some cases, as a result of high injection pressures and inaccurate methods, the injections provoked the propagation of the existing cracks or the initiation of new ones. Because of this situation and to determine the contribution of injection to dam safety, in 1985, Hydro-Quebec applied a moratorium on all future injection work on the dam. Research work was initiated in 1986 in the areas of grouting materials, methods, equipment and behavioral analysis to establish a safe method for the injection of the cracks. A committee was formed in 1993 with members from various groups, in order to: carry out extensive behavioral analysis of the Arch 5-6 dam, carry out an investigation program in order to determine the cause of the increase of the water infiltration, undertake a structural analysis program in order to evaluate the impact of an injection on the safety of the dam, and identify the proper method and injection products to use. In 1997, as a result of the progress of the structural analysis studies and the injection research project, a decision was made to proceed with the injection of the dam. A description is included of the results of the investigation, recommendations and results of the injection research project, as well as some details of the grouting campaign carried out in January 1999. On the whole, a better knowledge was acquired of the structure, of the plunging cracks and the behaviour of the dam during the injection. In the field of injection methods, materials and equipment, research work was invaluable when it came to the injection of micro-fine cracks in concrete dams. 5 refs., 8 figs

  17. Johnson Space Center's Risk and Reliability Analysis Group 2008 Annual Report

    Science.gov (United States)

    Valentine, Mark; Boyer, Roger; Cross, Bob; Hamlin, Teri; Roelant, Henk; Stewart, Mike; Bigler, Mark; Winter, Scott; Reistle, Bruce; Heydorn,Dick

    2009-01-01

    The Johnson Space Center (JSC) Safety & Mission Assurance (S&MA) Directorate s Risk and Reliability Analysis Group provides both mathematical and engineering analysis expertise in the areas of Probabilistic Risk Assessment (PRA), Reliability and Maintainability (R&M) analysis, and data collection and analysis. The fundamental goal of this group is to provide National Aeronautics and Space Administration (NASA) decisionmakers with the necessary information to make informed decisions when evaluating personnel, flight hardware, and public safety concerns associated with current operating systems as well as with any future systems. The Analysis Group includes a staff of statistical and reliability experts with valuable backgrounds in the statistical, reliability, and engineering fields. This group includes JSC S&MA Analysis Branch personnel as well as S&MA support services contractors, such as Science Applications International Corporation (SAIC) and SoHaR. The Analysis Group s experience base includes nuclear power (both commercial and navy), manufacturing, Department of Defense, chemical, and shipping industries, as well as significant aerospace experience specifically in the Shuttle, International Space Station (ISS), and Constellation Programs. The Analysis Group partners with project and program offices, other NASA centers, NASA contractors, and universities to provide additional resources or information to the group when performing various analysis tasks. The JSC S&MA Analysis Group is recognized as a leader in risk and reliability analysis within the NASA community. Therefore, the Analysis Group is in high demand to help the Space Shuttle Program (SSP) continue to fly safely, assist in designing the next generation spacecraft for the Constellation Program (CxP), and promote advanced analytical techniques. The Analysis Section s tasks include teaching classes and instituting personnel qualification processes to enhance the professional abilities of our analysts

  18. Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

    Science.gov (United States)

    Lerch, Marianne; Mainetti, Carlo; Terziroli Beretta-Piccoli, Benedetta; Harr, Thomas

    2018-02-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are considered a delayed-type hypersensitivity reaction to drugs. They represent true medical emergencies and an early recognition and appropriate management is decisive for the survival. SJS/TEN manifest with an "influenza-like" prodromal phase (malaise, fever), followed by painful cutaneous and mucous membrane (ocular, oral, and genital) lesions, and other systemic symptoms. The difference between SJS, SJS/TEN overlap, and TEN is defined by the degree of skin detachment: SJS is defined as skin involvement of  30%, and SJS/TEN overlap as 10-30% skin involvement. The diagnosis of different degrees of epidermal necrolysis is based on the clinical assessment in conjunction with the corresponding histopathology. The mortality rates for SJS and TEN have decreased in the last decades. Today, the severity-of-illness score for toxic epidermal necrolysis (SCORTEN) is available for SJS/TEN severity assessment. Drugs with a high risk of causing SJS/TEN are anti-infective sulfonamides, anti-epileptic drugs, non-steroidal anti-inflammatory drugs of the oxicam type, allopurinol, nevirapine, and chlormezanone. Besides conventional drugs, herbal remedies and new biologicals should be considered as causative agents. The increased risk of hypersensitivity reactions to certain drugs may be linked to specific HLA antigens. Our understanding of the pathogenesis of SJS/TEN has improved: drug-specific T cell-mediated cytotoxicity, genetic linkage with HLA- and non-HLA-genes, TCR restriction, and cytotoxicity mechanisms were clarified. However, many factors contributing to epidermal necrolysis still have to be identified, especially in virus-induced and autoimmune forms of epidermal necrolysis not related to drugs. In SJS/TEN, the most common complications are ocular, cutaneous, or renal. Nasopharyngeal, esophageal, and genital mucosal involvement with blisters, erosions as well as secondary development of strictures

  19. Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.

    Science.gov (United States)

    Hsu, Derek Y; Brieva, Joaquin; Silverberg, Nanette B; Paller, Amy S; Silverberg, Jonathan I

    2017-05-01

    Little is known about the epidemiology of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children. We sought to determine the morbidity, mortality, and comorbid health conditions of SJS and TEN in US children. This was a cross-sectional study of the 2009 to 2012 Nationwide Inpatient Sample, which contains a representative 20% sample of all US hospitalizations. Sociodemographics, inflation-adjusted cost, length of stay, comorbidities, and mortality were analyzed using descriptive statistics and multivariate regression analyses. The incidences of SJS, SJS-TEN, and TEN were a mean 5.3, 0.8, and 0.4 cases per million children per year in the US, respectively. Prolonged length of stay and higher costs of care (SJS: 9.4 ± 0.6 days, $24,947 ± $3171; SJS-TEN: 15.7 ± 1.5 days, $63,787 ± $8014; TEN: 20.4 ± 6.3 days, $102,243 ± $37,588) were observed compared with all other admissions (4.6 ± 0.1 days, $10,496 ± $424). Mortality was 0% for SJS, 4% for SJS-TEN, and 16% for TEN. In regression models, predictors of mortality included renal failure (adjusted OR [aOR] 300.28, 95% confidence interval [CI] 48.59->999.99), malignancy (aOR 54.33, 95% CI 9.40-314.22), septicemia (aOR 30.45, 95% CI 7.91-117.19), bacterial infection (aOR 20.38, 95% CI 5.44-76.36), and epilepsy (aOR 5.56, 95% CI 1.37-26.2). Data regarding treatment were not available. Date of diagnosis of comorbidities was not present, precluding temporal analysis. Pediatric SJS/TEN poses a substantial health burden in the United States. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  20. Genitourinary involvement and management in children with Stevens-Johnson syndrome and toxic epidermal necrolysis.

    Science.gov (United States)

    Van Batavia, J P; Chu, D I; Long, C J; Jen, M; Canning, D A; Weiss, D A

    2017-10-01

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are devastating hypersensitivity disorders that cause epidermal cell death and can affect all epidermal surfaces, including the urethra, vagina, labial and scrotal skin. Despite the well-described ocular and orofacial manifestations of SJS/TEN, there is a paucity of reports on the genitourinary (GU) symptoms and their management. Specifically, consulting services often ask the pediatric urology team if it is safe to place a urethral catheter, but there is no data in the literature to help guide management. The present study sought to review all pediatric cases of SJS/TEN in a tertiary care hospital to determine the incidence and optimal management of GU manifestations, including the use of urethral catheters. With IRB approval, cases of SJS and TEN that were managed as an inpatient between January 2008 and June 2015 were retrospectively reviewed in order to identify the extent of GU involvement/manifestations, the treatment provided, use of urethral catheterization and long-term follow-up or complications. Thirty-one patients (15 female, 16 male; age range 2-18 years) presented with SJS or TEN over the study period. Etiologies for SJS/TEN included mycoplasma infection (48%) and medications (45%). Incidences of GU manifestations at presentation and their management are shown in Summary Table. Overall, 74% of patients had genital involvement of skin lesions. In 12 cases (39%), urology consultation was obtained. Twenty patients (61%) complained of dysuria and one child had gross hematuria in the setting of meatal lesion. Petroleum jelly was used in the majority of patients. A urethral catheter was placed in eight patients (25.8%, four female, four male) with a range of duration of 7-23 days. No patient developed hematuria or any other complications (i.e. strictures or urinary symptoms) after catheter removal. One boy required lysis of penile adhesions in the short-term. One of each gender developed

  1. An improved electronic determination of the Boltzmann constant by Johnson noise thermometry

    Science.gov (United States)

    Qu, Jifeng; Benz, Samuel P.; Coakley, Kevin; Rogalla, Horst; Tew, Weston L.; White, Rod; Zhou, Kunli; Zhou, Zhenyu

    2017-08-01

    Recent measurements using acoustic gas thermometry have determined the value of the Boltzmann constant, k, with a relative uncertainty less than 1  ×  10-6. These results have been supported by a measurement with a relative uncertainty of 1.9  ×  10-6 made with dielectric-constant gas thermometry. Together, the measurements meet the requirements of the International Committee for Weights and Measures and enable them to proceed with the redefinition of the kelvin in 2018. In further support, we provide a new determination of k using a purely electronic approach, Johnson noise thermometry, in which the thermal noise power generated by a sensing resistor immersed in a triple-point-of-water cell is compared to the noise power of a quantum-accurate pseudo-random noise waveform of nominally equal noise power. The experimental setup differs from that of the 2015 determination in several respects: a 100 Ω resistor is used as the thermal noise source, identical thin coaxial cables made of solid beryllium-copper conductors and foam dielectrics are used to connect the thermal and quantum-accurate noise sources to the correlator so as to minimize the temperature and frequency sensitivity of the impedances in the connecting leads, and no trimming capacitors or inductors are inserted into the connecting leads. The combination of reduced uncertainty due to spectral mismatches in the connecting leads and reduced statistical uncertainty due to a longer integration period of 100 d results in an improved determination of k  =  1.380 649 7(37)  ×  10-23 J K-1 with a relative standard uncertainty of 2.7  ×  10-6 and a relative offset of 0.89  ×  10-6 from the CODATA 2014 recommended value. The most significant terms in the uncertainty budget, the statistical uncertainty and the spectral-mismatch uncertainty, are uncorrelated with the corresponding uncertainties in the 2015 measurements.

  2. Anatomic relationship between left coronary artery and left atrium in patients undergoing atrial fibrillation ablation.

    Science.gov (United States)

    Anselmino, Matteo; Torri, Federica; Ferraris, Federico; Calò, Leonardo; Castagno, Davide; Gili, Sebastiano; Rovera, Chiara; Giustetto, Carla; Gaita, Fiorenzo

    2017-07-01

    Atrial fibrillation transcatheter ablation (TCA) is, within available atrial fibrillation rhythm control strategies, one of the most effective. To potentially improve ablation outcome in case of recurrent atrial fibrillation after a first procedure or in presence of structural myocardial disease, isolation of the pulmonary veins may be associated with extensive lesions within the left atrium. To avoid rare, but potentially life-threatening, complications, thorough knowledge and assessment of left atrium anatomy and its relation to structures in close proximity are, therefore, mandatory. Aim of the present study is to describe, by cardiac computed tomography, the anatomic relationship between aortic root, left coronary artery and left atrium in patients undergoing atrial fibrillation TCA. The cardiac computed tomography scan of 21 patients affected by atrial fibrillation was elaborated to segment left atrium, aortic root and left coronary artery from the surrounding structures and the following distances measured: left atrium and aortic root; left atrium roof and aortic root; left main coronary artery and left atrium; circumflex artery and left atrium appendage; and circumflex artery and mitral valve annulus. Above all, the median distance between left atrium and aortic root (1.9, 1.5-2.1 mm), and between circumflex artery and left atrium appendage ostium (3.0, 2.1-3.4 mm) were minimal (≤3 mm). None of measured distances significantly varied between patients presenting paroxysmal versus persistent atrial fibrillation. The anatomic relationship between left atrium and coronary arteries is extremely relevant when performing atrial fibrillation TCA by extensive lesions. Therefore, at least in the latter case, preablation imaging should be recommended to avoid rare, but potentially life-threatening, complications with the aim of an as well tolerated as possible procedure.

  3. Johnson Space Center's Free Range Bicycle Program.- Fall 2015 Intern Report

    Science.gov (United States)

    Lee-Stockton, Willem

    2015-01-01

    NASA's Johnson Space Center is a big place, encompassing 1,620 acres and more than a hundred buildings. Furthermore, there are reportedly 15 thousand employees, all of which have somewhere to be. To facilitate the movement of all these people JSC has historically relied on human power. Pedaling their way towards deep space, bicycles have been the go to method. Currently there are about 200 Free Range Bicycles at JSC. Free Range Bicycles belong to nobody, except NASA, and are available for anybody to use. They are not to be locked or hidden (although frequently are) and the intention is that there will always be a bike to hop on to get where you're going (although it may not be the bike you rode in on). Although not without its own shortcomings, the Free Range Bicycle Program has continued to provide low cost, simple transportation for NASA's JSC. In addition to the approximately 200 Free Range Bicycles, various larger divisions (like engineering) will often buy a few dozen bikes for their team members to use or individuals will bring their own personal bike to either commute or use on site. When these bicycles fall into disrepair or are abandoned (from retirees etc) they become a problem at JSC. They are an eye sore, create a safety hazard and make it harder to find a working bike in a time of need. The Free Range Program hopes to address this first problem by "tagging out" abandoned or out of service bicycles. A bright orange "DO NOT OPERATE" tag is placed on the bike and given a serial number for tracking purposes. See picture to the right. If the bike has an active owner with intentions to repair the bike the bottom of the tag has instructions for how to claim the abandoned bicycle. After being tagged the owner of the bicycle has 30 days to claim the bicycle and either haul it off site or get it repaired (and labeled) in accordance with Johnson's Bicycle Policy. If the abandoned bicycle is not claimed within 30 days it becomes the property of the Government. The

  4. Beware the left-sided gallbladder

    African Journals Online (AJOL)

    %, and is defined as a gallbladder located to the left of the ligamentum teres and the falciform ligament.1 LSGB was first described by Hochstetter in 1886, and its identification is important because of the numerous and potentially hazardous.

  5. Introduction to left-right symmetric models

    International Nuclear Information System (INIS)

    Grimus, W.

    1993-01-01

    We motivate left-right symmetric models by the possibility of spontaneous parity breaking. Then we describe the multiplets and the Lagrangian of such models. Finally we discuss lower bounds on the right-handed scale. (author)

  6. Electrocardiographic features suggestive of a left. ventricular ...

    African Journals Online (AJOL)

    Abstract. Electrocardiographic features suggestive of a transmural anterior myocardial infarction with resultant left ventricular aneurysm formation were found in a 22-year-old man who had sustained a ballistic missile injury to his chest.

  7. No Child Left Inside Week: Pilot Program

    OpenAIRE

    Clark, Jamie C.

    2013-01-01

    This program evaluation assessed the feasibility and effectiveness of a free No Child Left Inside (NCLI) week-long outdoor program to coincide with the Utah state-designated No Child Left Inside Week. The pilot program was implemented at the community level in Cache Valley, Utah, in 2012. Families attended eleven activities throughout the week that included hands-on experience and participation. A community BioBlitz was also planned as a conclusion to the week. Survey results demonstrate incr...

  8. Drilling simulated temporal bones with left-handed tools: a left-hander's right?

    Science.gov (United States)

    Torgerson, Cory S; Brydges, Ryan; Chen, Joseph M; Dubrowski, Adam

    2007-11-01

    Left-handed trainees can be at a disadvantage in the surgical environment because of a right-handed bias. The effectiveness of teaching left-handed trainees to use an otologic drill designed for their dominant hand versus the conventional right-handed drill was examined. Novice medical students were recruited from the university community. Twenty-four subjects were left-handed, and 12 were right-handed. Eight left-handed surgeons also participated. A randomized controlled trial was conducted to compare the performance of left-handed trainees using novel left-handed drills to that of left-handed trainees using right-handed tools and to that of right-handed trainees using right-handed tools. The evaluation consisted of 3 phases: pretest, skill acquisition, and 2 post-tests. The measurement tools included expert assessment of performance, and subjective and objective final product analyses. An initial construct validity phase was conducted in which validity of the assessment tools was ensured. Both the left-handers using left-handed tools and the right-handers using right-handed tools significantly outperformed the left-handers using right-handed tools at pretest, immediate posttest, and delayed posttest. All participants improved their performance as a function of practice. The left-handed trainees learned bone drilling better with tools designed for the left hand. These tools may be incorporated into residency training programs for the development of surgical technical skills. Future studies should assess skill transfer between the left-handed and right-handed drills.

  9. Stevens-Johnson syndrome and toxic epidermal necrolysis: efficacy of intravenous immunoglobulin and a review of treatment options.

    Science.gov (United States)

    Teo, L; Tay, Y K; Liu, T T; Kwok, C

    2009-01-01

    Toxic epidermal necrolysis (TEN) is a rare, severe adverse drug reaction. Steven-Johnson syndrome (SJS) represents the milder end of the spectrum. The exact pathogenesis of TEN and SJS is still unknown and many drugs, including prednisolone, cyclosporin and intravenous immunoglobulin (IVIG), have been used in an attempt to halt the disease process. The use of IVIG in particular is controversial. We share our experience with the use of IVIG in six patients with TEN. We will also review the various proposed mechanisms underlying TEN, the mechanism of action of IVIG in TEN and summarise useful treatment options.

  10. Oral lesions associated with Nevirapine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A report of 10 cases.

    Science.gov (United States)

    Reddy, Ramana Bv; Shekar, P Chandra; Chandra, K Lalith Prakash; Aravind, Rs

    2013-09-01

    Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are closely related severe, acute mucocutaneous reactions usually caused by drugs. They are acute life-threatening conditions and cause widespread necrosis of the epithelium. There is persistence of a high risk of SJS or TEN in relation to human immunodeficiency virus (HIV) infection associated with exposure to nevirapine (NVP). In this article, we present nine cases of SJS and one case of TEN in HIV-seropositive individuals who developed cutaneous, oral, ocular and genital lesions while being treated with NVP.

  11. Availability and Quality of Water from Underground Coal Mines in Johnson and Martin Counties, Kentucky

    Science.gov (United States)

    Mull, D.S.; Cordivio1a, Steven; Risser, Dennis W.

    1981-01-01

    This report provides water users with detailed information on the location, quantity, and quality of water available from underground coal mines in the Breathitt Formation of Pennsylvanian age in part of eastern Kentucky. The principal coal seams mined are the Van Lear in Johnson County and the Alma in Martin County. Coal mines that contained water were located by field inventory and coal-mine maps. The principal factors that affect the occurrence of water in coal mines are the size of the recharge area overlying the mine, the intensity and duration of precipitation, and the altitude of the mine relative to that of the nearest perennial stream. Ten above-drainage mines (that is, mines at higher elevations than that of the nearest perennial stream) are considered potential sources of water. Discharge from these mines ranged from 12 to 1,700 gallons per minute. The highest sustained discharge from a mine ranged from 750 to 1,200 gallons per minute. The water in coal mines is part of the hydrologic system and varies seasonally with precipitation. Annual discharge from most above-drainage mines ranged from 3 to 10 percent of annual precipitation on the 1and-surface area above the mine. Eight below-drainage mines are considered potential sources of water. Two were test-pumped at rates of 560 to 620 gallons per minute for as long as 6 hours. After test pumping the Warfield Mining No. 1 mine during September 1977 and March 1978, the recovery (or recharge) rates were significantly different. In September, the recharge rate was about 1,150 gallons per minute, but in March the recharge rate was 103,500 gallons per minute. This difference reflects the seasonal variations in the amount of water available to the ground-water system. Estimates of water stored in below-drainage mines ranged from 22 to 1,462 million gallons. This storage represents a safety factor sufficient to provide water through periods of limited recharge to the mine. Most mine water is of the calcium

  12. Isaac Newton learns Hebrew: Samuel Johnson's Nova cubi Hebræi tabella

    Science.gov (United States)

    Joalland, Michael; Mandelbrote, Scott

    2016-01-01

    This article concerns the earliest evidence for Isaac Newton's use of Hebrew: a manuscript copy by Newton of part of a work intended to provide a reader of the Hebrew alphabet with the ability to identify or memorize more than 1000 words and to begin to master the conjugations of the Hebrew verb. In describing the content of this unpublished manuscript and establishing its source and original author for the first time, we suggest how and when Newton may have initially become acquainted with the language. Finally, basing our discussion in part on an examination of the reading marks that Newton left in the surviving copies of Hebrew grammars and lexicons that he owned, we will argue that his interest in Hebrew was not intended to achieve linguistic proficiency but remained limited to particular theological queries of singular concern.

  13. Left Right Patterning, Evolution and Cardiac Development

    Directory of Open Access Journals (Sweden)

    Iain M. Dykes

    2014-04-01

    Full Text Available Many aspects of heart development are determined by the left right axis and as a result several congenital diseases have their origins in aberrant left-right patterning. Establishment of this axis occurs early in embryogenesis before formation of the linear heart tube yet impacts upon much later morphogenetic events. In this review I discuss the differing mechanisms by which left-right polarity is achieved in the mouse and chick embryos and comment on the evolution of this system. I then discus three major classes of cardiovascular defect associated with aberrant left-right patterning seen in mouse mutants and human disease. I describe phenotypes associated with the determination of atrial identity and venous connections, looping morphogenesis of the heart tube and finally the asymmetric remodelling of the embryonic branchial arch arterial system to form the leftward looped arch of aorta and associated great arteries. Where appropriate, I consider left right patterning defects from an evolutionary perspective, demonstrating how developmental processes have been modified in species over time and illustrating how comparative embryology can aide in our understanding of congenital heart disease.

  14. Left behind radiological investigations: An inherent problem

    Directory of Open Access Journals (Sweden)

    Giridhar A Govindswamy

    2011-01-01

    Full Text Available Objectives: To assess the number of investigations left behind by patients in radiology department, their cost, and the possible methods of reducing the problem. Materials and Methods: A total of 1424 radiographs, 160 computed tomography (CT scans, 300 ultrasonography (USG reports, and 46 Doppler reports were left behind by patients in one financial year. The total cost of these left behind investigations was calculated and the reports were categorized into normal and abnormal for each modality. Results: Of the radiographs left behind 658 were abnormal, with 211 among these being radiographs of postoperative patients. Thirty-seven percent of CT scans had positive findings. Sixty-eight percent of USG reports had positive findings while 46% of Doppler reports were abnormal. Conclusion: We believe that the cost and number of these left behind investigations over a period of time would definitely be significant for the health care system in a developing country. It is time to think of the possible reasons and methods for containing this problem.

  15. Left atrial laceration with epicardial ligation device.

    Science.gov (United States)

    Keating, Vincent P; Kolibash, Christopher P; Khandheria, Bijoy K; Bajwa, Tanvir; Sra, Jasbir; Kress, David C

    2014-01-01

    Many new devices and techniques are being developed to attempt a reduction in embolic stroke risk for patients with atrial fibrillation who are either unable or unwilling to maintain long-term anticoagulation. One of these new devices (LARIAT®, SentreHEART Inc., Redwood City, California, USA) employs delivery of an epicardial suture to ligate the left atrial appendage after percutaneous pericardial and transseptal access. This series presents three clinical cases that demonstrate a serious and recurrent complication of left atrial laceration and cardiac tamponade shortly following delivery of an epicardial suture ligation to the left atrial appendage. Three clinical cases are described in detail with pre- and postprocedure angiography and echocardiography as well as illustrations reflecting the surgeon's findings on direct visualization of the left atrial lacerations postligation. Potential hypotheses of each injury are examined in light of the case timelines and findings at sternotomy. There was no suggestion that tamponade was related to pericardial or transseptal access, but rather a complication with device delivery. These three patients quickly progressed to clinical cardiac tamponade despite attempted drainage, stressing the importance of cardiovascular surgery backup, including a cardiopulmonary bypass pump, when delivering novel, percutaneous ligation devices for the left atrial appendage.

  16. Stevens–Johnson syndrome and toxic epidermal necrolysis in an academic hospital setting: a 5-year retrospective study

    Directory of Open Access Journals (Sweden)

    Ewa Stocka-Łabno

    2016-10-01

    Full Text Available Introduction: Toxic epidermal necrolysis and Stevens–Johnson syndrome are acute life-threatening mucocutaneous reactions to drugs. The aims of the study were to identify these drugs and characterize population prone to these reactions. Materials and Methods: Data including demographics, culprit drug, clinical characteristics, course of disease, treatment given, and therapeutic responses were retrospectively collected from medical records of 31 patients admitted to Department of Dermatology from January 2009 to December 2014. Results: Drugs most commonly involved in Stevens–Johnson syndrome were antimicrobials: ciprofloxacin, doxycycline, cefuroxime, trimethoprim, amoxicillin, clindamycin, co-trimoxazole (50% of patients and nonsteroidal anti-inflammatory drugs: ibuprofen, naproxen, metamizole, piroxicam (29% of patients. Drugs involved in toxic epidermal necrolysis were antimicrobials: sulfasalazine, co-trimoxazole, cefuroxime, clindamycin (71% of patients and anticonvulsants: lamotrigine (29% of patients. The comorbidities’ characteristic for the group of patients affected by toxic epidermal necrolysis were psychiatric and autoimmune disorders. The most common complication was infection. Two patients died and in both cases the cause of death was sepsis. Conclusion: The study indicates that in observed population drugs with the highest risk of most severe reactions are lamotrigine (anticonvulsant and antimicrobials (most commonly sulfonamides, therefore it is advisable to consider carefully administration of these drugs, especially to patients with history of autoimmune reactions.

  17. Band gap calculations of the semiconductor BNxP1−x using modified Becke–Johnson approximation

    International Nuclear Information System (INIS)

    Benkraouda, M.; Amrane, N.

    2013-01-01

    Highlights: ► The Modified Becke–Johnson scheme gives a very accurate band gap. ► We have shown the invalidity of Vegard’s linear rule for BN x P 1−x . ► The band gap changes with alloy concentration are important in band gap engineering. - Abstract: In this work, the electronic properties of BN, BP and BN x P 1−x compounds have been investigated by means of first-principles density-functional total-energy calculation using the all-electron full potential linear augmented plane-wave method (FP-LAPW). The (FP-LAPW) method was used within the density functional theory (DFT) along with the Engel–Vosko and Becke–Johnson exchange correlation potential. The energy bands along high symmetry directions, the density of states and bowing distributions are calculated. The results have been discussed in terms of previously existing experimental and theoretical data, and comparisons with similar compounds have been made. Analysis of band structure suggests direct and pseudo-direct band gaps for both compounds.

  18. Evolution of the Behavioral Sciences Branch of the Space Medicine and Health Care Systems Office at the Johnson Space Center.

    Science.gov (United States)

    Fiedler, Edna R; Carpenter, Frank E

    2005-06-01

    This paper presents a brief history of psychology and psychiatry roles in psychological selection and how these roles have evolved into the Behavioral Sciences Branch at the Johnson Space Center USC), Houston, TX. Since the initial selection of the Mercury Seven, the first United States astronauts, psychologists and psychiatrists have been involved in astronaut selection activities. Initially very involved in psychological selection of astronauts, the role of behavioral health specialists waned during the Gemini and Apollo years. With the onset of the NASA/Mir/International Space Station Program, the introduction of payload and mission specialists, and international collaboration, the evolving need for behavioral health expertise became apparent. Medical and psychological selection processes were revisited and the Johnson Space Center developed a separate operational unit focused on behavioral health and performance. This work unit eventually became the Behavioral Sciences branch of the Space Medicine and Health Care Systems Office. Research was allocated across groups at JSC, other NASA space centers, and the National Space Biomedical Research Institute, and was funded by NASA Headquarters. The current NASA focus on human space exploration to the Moon and beyond re-emphasizes the importance of the human-centered approach.

  19. Effectiveness, safety and tolerability of cyclosporine versus supportive treatment in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A record-based study.

    Science.gov (United States)

    Mohanty, Swosti; Das, Anupam; Ghosh, Anupama; Sil, Amrita; Gharami, Ramesh Chandra; Bandyopadhyay, Debabrata; Das, Nilay Kanti

    2017-01-01

    Toxic epidermal necrolysis and Stevens-Johnson syndrome comprise life-threatening, drug-induced mucocutaneous disease spectrum. Interest in cyclosporine, a calcineurin inhibitor that can block the function of T-cells, has increased with the discovery of the importance of granulysin in apoptosis in toxic epidermal necrolysis. In our hospital, cyclosporine is given to Stevens-Johnson syndrome/toxic epidermal necrolysis patients as an adjunctive therapy. This study is an observational, record-based study comparing the effectiveness and safety of patients receiving cyclosporine versus only supportive therapy. Medical records as bed-head tickets and laboratory investigation reports of Stevens-Johnson syndrome/toxic epidermal necrolysis patients admitted in the hospital over a period of 1 year were collected. Data regarding clinico-demographic profile, suspected drug causing Stevens-Johnson's syndrome/toxic epidermal necrolysis, SCORTEN, body surface area involved, treatment received and outcome were obtained. Twenty-eight patients were analyzed. Nineteen belonged to the cyclosporine group (supportive treatment + cyclosporine), nine to supportive treatment only group. Among the suspected drugs, antiepileptics formed the major group (28.6%). Five patients in the supportive only group and one in the cyclosporine group died. Time for stabilization and reepithelialization and duration of recovery were significantly lower in the cyclosporine group (P Stevens-Johnson syndrome/toxic epidermal necrolysis may decrease the risk of dying, may provide faster healing of lesions and might lead to early discharge from hospital.

  20. Left-Wing Extremism: The Current Threat

    Energy Technology Data Exchange (ETDEWEB)

    Karl A. Seger

    2001-04-30

    Left-wing extremism is ''alive and well'' both in the US and internationally. Although the current domestic terrorist threat within the U. S. is focused on right-wing extremists, left-wing extremists are also active and have several objectives. Leftist extremists also pose an espionage threat to U.S. interests. While the threat to the U.S. government from leftist extremists has decreased in the past decade, it has not disappeared. There are individuals and organizations within the U.S. who maintain the same ideology that resulted in the growth of left-wing terrorism in this country in the 1970s and 1980s. Some of the leaders from that era are still communicating from Cuba with their followers in the U.S., and new leaders and groups are emerging.

  1. Left ventricular performance during psychological stress

    International Nuclear Information System (INIS)

    Young, D.Z.; Massachusetts General Hospital, Boston; Dimsdale, J.E.; Moore, R.H.; Barlai-Kovach, M.; Newell, J.B.; McKusick, K.A.; Boucher, C.A.; Fifer, M.A.; Strauss, H.W.

    1989-01-01

    Left ventricular ejection fraction, systolic blood pressure and plasma norepinephrine were measured in six normotensive and six mildly hypertensive subjects during rest and psychological stress. Compared with rest, 8 of the 12 subjects developed significant changes in ejection fraction (increase in 6, decrease in 2); 10 of 12 subjects developed significant elevations of plasma norepinephrine; and all developed significant increases in systolic blood pressure. When the stress effects were examined for the total group, as opposed to within subjects, there were significant increases in plasma norepinephrine and systolic blood pressure but, interestingly, mean ejection fraction and stroke volume remained unchanged, implying stress led to increased left ventricular contractility. (orig.)

  2. Echocardiographic study of left atrial myxoma

    Directory of Open Access Journals (Sweden)

    Dalal J

    1979-01-01

    Full Text Available Four cases of left atrial myxoma were diagnosed pre-operatively by echocardiography. All cases showed characteristic echocardio-graphic features of variegated shadows behind the mitral valve in diastole and within the left atrium in systole. In two cases the my-xomas were surgically removed and confirmed on histology. In one case the post-operative echocardiogram showed complete dis-appearance of the abnormal shadows. Echocardiography is the most reliable method today for the diagnosis of a myxoma.

  3. “Getting the Left Right”

    DEFF Research Database (Denmark)

    Klinke, Marianne E.; Zahavi, Dan; Hjaltason, Haukur

    2015-01-01

    experience was captured in the overarching theme, “getting the left right,” which encompasses the two subthemes of (a) surreal awareness of the left and (b) emergence of a different world. Patients had unclear perceptions of their own body and surroundings, their attention was brittle, and they encountered...... bewildering reactions from other people. They simultaneously pursued the ineffable neglected space and searched for coherence. The vulnerability, loss, and conflicting perceptions that patients with neglect face should be acknowledged and alleviation sought. Facilitating methods should provide additional...

  4. Clustered survival data with left-truncation

    DEFF Research Database (Denmark)

    Eriksson, Frank; Martinussen, Torben; Scheike, Thomas H.

    2015-01-01

    Left-truncation occurs frequently in survival studies, and it is well known how to deal with this for univariate survival times. However, there are few results on how to estimate dependence parameters and regression effects in semiparametric models for clustered survival data with delayed entry....... Surprisingly, existing methods only deal with special cases. In this paper, we clarify different kinds of left-truncation and suggest estimators for semiparametric survival models under specific truncation schemes. The large-sample properties of the estimators are established. Small-sample properties...

  5. Left paraduodenal hernias; Hernias paraduodenales izquierdas

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Negrete, L.; Garcia-Lozano, J.; Sanchez, J. L.; Tejeiro, A.; Sala, J. [Hospital Valle del Nalon. Riano-Sama. Asturias (Spain)

    2002-07-01

    We report two cases of left paraduodenal internal hernias located in the fossa of Landzert that were diagnosed by CT. Internal hernias are an infrequent cause of acute abdomen, due to the intestinal sub occlusion they produce. Left paraduodenal hernias are responsible for about 50% of internal hernias. CT makes it possible to demonstrate the group of herniated loops between the stomach, fourth segment of the duodenum, descending colon, and tail of the pancreas. The identification of the loops in an atypical position together with displaced blood vessels (mesenteric vessels) and colon gives concerns on them a typical radiological semiology that makes them easily identifiable. (Author) 9 refs.

  6. Left ventricular assist device implantation via left thoracotomy: alternative to repeat sternotomy.

    Science.gov (United States)

    Pierson, Richard N; Howser, Renee; Donaldson, Terri; Merrill, Walter H; Dignan, Rebecca J; Drinkwater, Davis C; Christian, Karla G; Butler, Javed; Chomsky, Don; Wilson, John R; Clark, Rick; Davis, Stacy F

    2002-03-01

    Repeat sternotomy for left ventricular assist device insertion may result in injury to the right heart or patent coronary grafts, complicating intraoperative and postoperative management. In 4 critically ill patients, left thoracotomy was used as an alternative to repeat sternotomy. Anastomosis of the outflow conduit to the descending thoracic aorta provided satisfactory hemodynamic support.

  7. Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials.

    Science.gov (United States)

    Bloom, Romi; Amber, Kyle T

    2017-01-01

    Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the incidence of cutaneous reactions, particularly Stevens-Johnson syndrome/toxic epidermal necrolysis. Of a total of 4,364 papers regarding lamotrigine, 122 studies met our inclusion and exclusion criteria. In total, 18,698 patients were included with 1,570 (8.3%) of patients experiencing an adverse dermatologic reaction. The incidence of Stevens-Johnson syndrome/toxic epidermal necrolysis was 0.04%.

  8. Magnetization of left-handed metamaterials

    International Nuclear Information System (INIS)

    Kourakis, I; Shukla, P K

    2006-01-01

    We propose a possible mechanism for the generation of magnetic fields in negative refraction index composite metamaterials. Considering the propagation of a high-frequency modulated amplitude electric field in a left-handed material (LHM), we show that the ponderomotive interaction between the field and low-frequency potential distributions leads to spontaneous generation of magnetic fields, whose form and properties are discussed

  9. Left ventricular mass: Myxoma or thrombus?

    Directory of Open Access Journals (Sweden)

    Monish S Raut

    2015-01-01

    Full Text Available Patient with embolic episode should always be evaluated for cardiac mass. Mass in left ventricular can be a myxoma or thrombus even in a normal functioning heart . In either case, mobile mass with embolic potential should be surgically resected.

  10. Left atrial myxoma with biventricular dysfunction

    Directory of Open Access Journals (Sweden)

    Monish S. Raut

    2016-09-01

    Full Text Available Occurrence of left atrial myxoma with severe ventricular dysfunction without any obstructive coronary artery disease, as presented in our case, is very rare. It may be due to undiagnosed concomitant dilated cardiomyopathy or unknown cardiodepressant effect of myxoma which warrants further research.

  11. Left atrial myxoma with biventricular dysfunction.

    Science.gov (United States)

    Raut, Monish S; Shad, Sujay; Maheshwari, Arun

    2016-09-01

    Occurrence of left atrial myxoma with severe ventricular dysfunction without any obstructive coronary artery disease, as presented in our case, is very rare. It may be due to undiagnosed concomitant dilated cardiomyopathy or unknown cardiodepressant effect of myxoma which warrants further research. Copyright © 2016 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  12. Vergisson 4: a left-handed Neandertal.

    Science.gov (United States)

    Condemi, Silvana; Monge, Janet; Quertelet, Sylvain; Frayer, David W; Combier, Jean

    2017-01-01

    Handedness is an important marker for lateralization of humans in the modern and fossil record. For the most part, Neandertals and their ancestors are strongly right-handed. We describe a single tooth from a Neandertal level at Vergisson 4 (Vg 4-83). This left upper central incisor shows all the features typical of Neandertal incisors. It also exhibits a predominance of left-handed striations. Striations on the incisor's labial surface were mapped at 20x magnification using Photoshop. Angulations of the striations were determined from their deviation from the maximum mesio-distal line and were analyzed using NIH's freeware, Image J. Of the 60 labial surface striations, Vg 4-83 shows a strong predominance of left-handed striations (46; 76.7%), which are statistically significantly different (p handed striations. The identification of another left-handed Neandertal adds to our understanding about handedness variation in this fossil hominin. Given the high frequency of right-handed Neandertals, the 90: 10 modern ratio is still preserved in this group. © 2016 Wiley Periodicals, Inc.

  13. Electrocardiographic features suggestive of a left. ventricular ...

    African Journals Online (AJOL)

    1983-01-01

    Jan 1, 1983 ... sniper with an Armourlite assault rifle in Ireland. He had received a single bullet injury to the left ... His history negated any cardiovascular impairment, angina or limitation in effort tolerance. He plays ... In view of the patient's age, history and the cardiovascular findings, we would like to postulate that the ...

  14. Radiative left-right Dirac neutrino mass

    Science.gov (United States)

    Ma, Ernest; Sarkar, Utpal

    2018-01-01

    We consider the conventional left-right gauge extension of the standard model of quarks and leptons without a scalar bidoublet. We study systematically how one-loop radiative Dirac neutrino masses may be obtained. In addition to two well-known cases from almost 30 years ago, we find two new scenarios with verifiable predictions.

  15. Giant melanoma of the left thumb

    NARCIS (Netherlands)

    Zeebregts, CJAM; Schraffordt Koops, H.

    A 74-year-old female patient is described with a giant melanoma of the left thenar and concomitant bilateral pulmonary metastases. Palliative treatment consisted of a two-staged procedure in order to save the limb from amputation. Firstly, perfusion with gamma-interferon, tumour necrosis

  16. Submitral Left Ventricular Aneurysm Associated with Thrombus

    African Journals Online (AJOL)

    2018-01-01

    Jan 1, 2018 ... She was given drugs for management of heart failure and ... treatment abroad. KEYWORDS: Ethiopia, heart failure, submitral aneurysm, thrombus. INTRODUCTION. Submitral left ventricle aneurysm is a rare cardiovascular disorder worldwide, but ... grade 2 pulmonary edema, and bilateral pleural effusion.

  17. Left-Right Symmetry at LHC

    CERN Document Server

    Maiezza, Alessio; Nesti, Fabrizio; Senjanovic, Goran

    2010-01-01

    We revisit the issue of the limit on the scale of Left-Right symmetry breaking. We focus on the minimal SU(2)_L x SU(2)_R x U(1)_B-L gauge theory with the seesaw mechanism and discuss the two possibilities of defining Left-Right symmetry as parity or charge conjugation. In the commonly adopted case of parity, we perform a complete numerical study of the quark mass matrices and the associated left and right mixing matrices without any assumptions usually made in the literature about the ratio of vacuum expectation values. We find that the usual lower limit on the mass of the right-handed gauge boson from the K mass difference, M_WR>2.5TeV, is subject to a possible small reduction due to the difference between right and left Cabibbo angles. In the case of charge conjugation the limit on M_WR is somewhat more robust. However, the more severe bounds from CP-violating observables are absent in this case. In fact, the free phases can also resolve the present mild discrepancy between the Standard Model and CP-violat...

  18. Left Dislocation: a typological overview | Westbury | Stellenbosch ...

    African Journals Online (AJOL)

    The Left Dislocation construction is a typologically universal phenomenon that has received detailed analysis, from both formal and functional perspectives, in a number of genetically and areally diverse languages. The present paper aims to provide a general overview of this cross-linguistic research with a concentration ...

  19. Left-forbidding cooperating distributed grammar systems

    Czech Academy of Sciences Publication Activity Database

    Goldefus, F.; Masopust, Tomáš; Meduna, A.

    2010-01-01

    Roč. 411, 40-42 (2010), s. 3661-3667 ISSN 0304-3975 Institutional research plan: CEZ:AV0Z10190503 Keywords : cooperating distributed grammar system * cooperating derivation mode * left-forbidding grammar * generative power * descriptional complexity Subject RIV: BA - General Mathematics Impact factor: 0.838, year: 2010 http://www.sciencedirect.com/science/article/pii/S0304397510003440

  20. Left Ventricular Thrombus among patients undergoing Transthoracic ...

    African Journals Online (AJOL)

    Objective: Left Ventricular Thrombus (LVT) is a well recognized complication of various cardiac conditions, particularly following an acute anterior myocardial infarction and in those with systolic congestive heart failure. Transthoracic echocardiography (TTE) remains the most common imaging modality to make the diagnosis ...