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Sample records for las neoplasias malignas

  1. Neoplasias malignas: caracterización

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    Freddie Hernández Cisneros

    1997-02-01

    Full Text Available Se realizó un estudio transversal con el objetivo de caracterizar a los pacientes con neoplasias malignas en un área de salud desde marzo de 1994 hasta agosto del mismo año; el universo de estudio estuvo representado por 75 pacientes diagnosticados con algún tipo de afección maligna y el registro primario de los datos, por una encuesta con variables seleccionadas; se procesó la información de una forma computadorizada. Se encontraron como resultados más importantes: una mayor incidencia en el grupo de edad de 50 años y más; un 56 % fumaba y un 17,33 % ingería bebidas alcohólicas; las 3 localizaciones más frecuentes fueron: mama, cuello del útero y piel, y se detectaron deficiencias llamativas en la promoción y la prevención de estas enfermedades.: A cross-sectional study was carried out, with the aim of characterizing the patients with malignant neoplasms in a health area, from March 1994 to August of the same year; the universe of study was represented by 75 patients diagnosed with some kind of malignant disease, and the primary score of the data, by means of a survey with selected variables; information was processed in a computed way. The most important results found, were: the highest incidence in the 50 years old or more age group; the 56 % smoked, and the 17.33 % drank alcoholic beverages; the three most frequent sites, were: breast, cervix uteri and skin, and also outstanding defficiencies were detected in the promotion and prevention of these diseases.

  2. Incidencia de las lesiones cutáneas malignas faciales

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    Jorge Luis Zequeira Peña

    2003-04-01

    Full Text Available Se realiza un estudio de las lesiones malignas de la piel facial en el Servicio de Cirugía Maxilofacial del Hospital "Manuel Ascunce Domenech" de Camagüey en los años 2000 y 2001. La información se obtuvo de 148 historias clínicas con el diagnóstico de lesiones malignas de la piel, de las cuales 42 correspondieron a lesiones de localización facial. La entidad que nos ocupa fue mayor en pacientes mayores de 50 años de edad, blancos, masculinos, con predominio en el tercio medio facial. Los principales tipos histológicos fueron: el carcinoma basocelular y el espinocelular, pero con mayor predominio en el primero. Se revisa el tema y se comparan nuestros resultados con los de otros autores.

  3. Hipertermia maligna: adelantándose a las complicaciones

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    González G,Cristian; Ulloa B,Patricio

    2006-01-01

    La hipertermia maligna (HTM) es una enfermedad fármaco-genética de carácter autosómico dominante de baja incidencia pero potencialmente mortal, caracterizada por un síndrome hipermetabólico del músculo estriado esquelético, que puede desencadenar la destrucción completa de éste, resultando en aumento de la temperatura corporal, alto consumo de oxígeno, hiperpotasemia, falla renal y arritmias. A continuación se da a conocer el caso de un paciente de 6 años portador de una distrofia muscular de...

  4. Tuberculose ileocecal isolada simulando neoplasia maligna e doença de Crohn

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    BROMBERG S.H.

    2001-01-01

    Full Text Available OBJETIVO: No Brasil, a tuberculose ileocecal isolada, na ausência de tuberculose pulmonar ativa ou cicatrizada, é rara, sendo freqüentemente confundida com neoplasia e a doença de Crohn. MÉTODOS: Os autores apresentam oito doentes com essas características, tratados por cirurgia, em período de 20 anos. A dor abdominal na fossa ilíaca direita foi o principal sintoma (100%, seguido da presença de perda de peso (62,5%, febre, náuseas e vômitos e fadiga em 50% dos doentes. Sete enfermos (87,5% apresentaram massa palpável na fossa ilíaca direita. A duração média dos sintomas foi de 14,7 meses, variando de 5 a 36 meses. Todas as lesões foram detectadas pelo enema opaco e mimetizavam aspecto neoplásico. A colonoscopia foi realizada em três doentes, evidenciando lesões sub-oclusivas da região íleo-cecal em dois; as biópsias foram sugestivas de tuberculose, não sendo possível diferenciá-las da doença de Crohn. RESULTADOS: Seis enfermos com diagnóstico presuntivo de neoplasia foram submetidos a cirurgia eletiva, realizando-se neles a colectomia direita clássica. Os outros dois, com suspeita de tuberculose, foram operados na vigência de obstrução intestinal, sendo submetidos a ressecção limitada (ileocecectomia. O estudo anatomopatológico estabeleceu o diagnóstico final pelo encontro de necrose caseosa e de bacilos álcool ácido-resistentes no intestino ou nos linfonodos. A evolução pós-operatória foi satisfatória, com pequena morbidade resolvida clinicamente. Posteriormente, todos os doentes receberam o esquema tríplice por 12 meses, variando a droga de acordo com a época do tratamento. CONCLUSÃO: Apesar de rara, a tuberculose hipertrófica ileocecal isolada freqüentemente é confundida com neoplasias e com a doença de Crohn, devendo ser lembrada no diagnóstico diferencial das lesões localizadas no quadrante inferior direito do abdome.

  5. Reconstrucción microquirúrgica de la lengua en pacientes con Neoplasias Malignas en estadios III y IV

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    Alonso Salja, Luis Eduardo

    2013-01-01

    Antecedentes: El tratamiento quirúrgico del cáncer de lengua, compromete funciones importantes como habla y deglución.La aparición de los colgajos libres en la reconstrucción lingual ha revolucionado los resultados funcionales y el proceso de rehabilitación, por lo tanto son en la actualidad el método reconstructivo de elección. Métodos: Estudio tipo serie de casos. Se incluyeron pacientes con diagnóstico de patología maligna de la lengua en estadios posoperatorios-histológicos III y...

  6. Estenosis malignas del estomago

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    Jácome Valderrama, José A.; Gutiérrez Arango, Roberto; Parra Torres, Augusto; Forero Laverde, Humberto; Medina Medina, Julio

    2011-01-01

    Al hablar de estenosis malignas del estomago, no vamos a referirnos a las obstrucciones producidas por lesiones extrínsecas, en las cuales influye como causa determinante el fenómeno mecánico de compresión exterior, sino a aquellas lesiones que primitivamente se originan en los tejidos del estomago, vale decir en sus paredes u orificios. Las estenosis intrínsecas malignas del estomago son producidas generalmente por tumores derivados de sus diferentes tejidos y por consiguiente se agrupan en ...

  7. Avaliação da acuracia do instrumental utilizado para o levantamento de dados de casos de neoplasias malignas em hospitais de Campinas : subsidios para a organização de um registro de cancer de base populacional

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    Anna Valeria Gervasio de Britto

    1992-01-01

    Resumo: Para subsidiar a estruturação de um Registro de Câncer de Base Populacional em Campinas ( RCBP ), foi definida uma estratégia, e elaborado e testado um instrumental para a coleta de dados sobre neoplasias malignas, constituido por: ficha de cadastro de caso e manual com orientações para o seu preenchimento (anexo 2) e orientações sobre o trabalho e as neoplasias (anexo 3). Foram treinadas duas atendentes de enfermagem para coleta dos dados (coletadoras) e uma pessoa (codificador...

  8. Hipertermia maligna

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    Carlos Vilaplana Santaló

    2002-08-01

    Full Text Available La hipertermia maligna es un desorden hipermetabólico de los músculos esqueléticos, caracterizado por hipercalcemia intracelular y consumo rápido de adenosín trifosfato; esta condición se desencadena por la exposición a 1 o más agentes anestésicos precipitantes incluidos halotano, enflurano, isoflurano, desflurano, sevoflurano y el succinilcolina. Los síntomas de esta afección pueden presentarse en el quirófano o en la Unidad de Cuidados Posanestésicos y se caracteriza por aparición súbita de taquicardia, taquipnea, hipertensión, hipercapnia, hipertermia, acidosis y rigidez musculoesquelética. El dantroleno atenúa la elevación del calcio intracelular y puede ser administrado de forma profiláctica o inmediatamente que se sospeche el diagnóstico. Con el objetivo de conocer las bases fisiopatológicas de este síndrome y las pautas de tratamiento más empleadas se realizó una exhaustiva revisión bibliográficaMalignant hyperthermia is a hypermetabolic disorder of the skeletal muscles, characterized by intracellular hypercalcemia and rapid consumption of adenosine triphosphate. This condition appears as a result of the exposure to 1 or more precipitating anesthetic agents, including halothane, enflurane, isoflurane, desflurane, sevoflurane and succinylcholine. The symptoms of this affection may be present in the operating room or in the Unit of Postanesthetic Care and it is characterized by the sudden appearance of thachycardia, tachypnea, hypertensiion, hypercapnia, hyperthermia, acidosis and muscoloskeletal rigidity. Dantrolene attenuates the elevation of intracellular calcium and may be prophylactically administered or as soon as the diagnosis is suspected. In order to know the physiopathological basis of this syndrome and the most used treatment patterns, an exhaustive bibliographic review was made

  9. Paracoccidioidomicose cutânea disseminada e pulmonar em paciente portador de neoplasia maligna visceral Cutaneous and pulmonary paracoccidioidomycosis in a patient with a malignant visceral tumor

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    Adriana Maria Porro

    2011-12-01

    Full Text Available Paracoccidioidomicose é doença causada pelo fungo Paracoccidioides brasiliensis, caracterizada por quadro polimórfico e acometimento preferencial de pele, mucosas, pulmões, linfonodos, adrenais e sistema nervoso. De acordo com o local de inoculação e o estado imunológico do indivíduo, ocorrem as diversas formas da doença: tegumentar, linfonodular, visceral e mista. Relatamos caso de paciente com quadro de paracoccidioidomicose mista (tegumentar e pulmonar, com lesões cutâneas caracterizadas por pápulas e pústulas disseminadas e sintomas sistêmicos, possivelmente associada a imunossupressão causada por neoplasia maligna visceral.Paracoccidioidomycosis is a systemic mycosis caused by the fungus Paracoccidioides brasiliensis that is characterized by polymorphous clinical manifestations principally affecting the skin, mucous membranes, lungs, lymph nodes, adrenal glands and the central nervous system. Depending on the site of inoculation and the individual's immunological status, the disease may take various different forms, affecting the skin, lymph nodes, viscera or a combination of these. The present report describes a patient with extensive cutaneous and pulmonary paracoccidioidomycosis, with disseminated papules and pustules, fever and pulmonary symptoms, probably related to immunosuppression caused by a renal carcinoma.

  10. Mortalidade por neoplasia maligna do fígado e vias biliares intra-hepáticas no Brasil, 1980-2010

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    Thiago Rodrigues de Amorim

    2013-07-01

    Full Text Available O objetivo deste trabalho foi analisar a tendência da mortalidade por neoplasia maligna do fígado e das vias biliares intra-hepáticas no Brasil, entre 1980 e 2010. Trata-se de um estudo de séries temporais com dados do Sistema de Informações sobre Mortalidade. Coeficientes de mortalidade brutos, padronizados, específicos por idade, região de residência e sexo foram calculados e as tendências analisadas utilizando-se modelos de regressão polinomial. Tendência crescente da mortalidade foi observada no Brasil, para ambos os sexos. O coeficiente médio de mortalidade para o país foi de 3,59 óbitos por 100 mil habitantes com aumento linear anual de 0,020 (R² = 0,588; p < 0,001, sendo para o sexo masculino de 4,20 óbitos por 100 mil homens, com aumento linear de 0,044 (R² = 0,81; p < 0,001 ao ano e, para o sexo feminino, de 2,98 por 100 mil mulheres, com aumento de 0,0194 (R² = 0,35; p = 0,008 ao ano. Discutem-se possíveis causas desse aumento bem como vieses de informação.

  11. Suplementação com imunoestimulante em cadelas com neoplasia mamária maligna: aspectos hematológicos e bioquímicos

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    Vilma F. Oliveira

    Full Text Available RESUMO: Os alimentos funcionais têm sido empregados como adjuvantes no tratamento do câncer de mama. Neste estudo avaliaram-se as respostas hematológicas e bioquímicas clínicas à ação de um alimento funcional administrado a cadelas com diagnóstico de neoplasia mamária maligna. Após a mastectomia, 16 cadelas foram divididas em dois grupos: suplementadas (S e não suplementadas (NS com um composto comercial contendo Saccharomyces cerevisiae, mananoligossacarídeos e nutracêuticos. Ambos grupos receberam tratamento quimioterápico com doxorrubicina e carboplatina, alternadamente, em intervalos de 21 dias, por oito sessões, totalizando 168 dias de tratamento. As avaliações clínicas e laboratoriais foram realizadas nos momentos de aplicação do tratamento. Os resultados dos perfis hematológico (hemograma, leucograma e plaquetograma e bioquímico sérico (ureia, creatinina, albumina, bilirrubina total e direta, alanina aminotransferase, fosfatase alcalina e gama glutamiltransferase - GGT foram analisados pelo teste de Kruskall Wallis. No grupo S comprovou-se elevação do peso corporal e não foram observados transtornos gastrointestinais ou outros sinais de alteração clínica ao longo do tratamento. Diferentemente no grupo NS, ocorreu perda de peso e alterações clínicas, como diarreia e vômito. No quadro hematológico, constatou-se leucopenia por linfopenia no grupo de cadelas NS e preservação do valores dentro dos parâmetros considerados normais para a espécie no grupo S. Dentre todas as variáveis da bioquímica clínica, constatou-se apenas a elevação da atividade sérica da GGT nos animais do grupo NS, sem alterações no grupo S. Conclui-se que cadelas com neoplasia mamária quando suplementadas com com alimento funcional imunoestimulante apresentam melhor condição clínica, hematológica e dos níveis bioquímicos, particularmente da GGT.

  12. Caracterización de las lesiones premalignas y malignas de la cavidad bucal en pacientes de Amancio, 2010-2012

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    Tomas de la Paz Suárez

    2014-08-01

    Full Text Available Se realizó un estudio observacional descriptivo retrospectivo, para caracterizar las lesiones premalignas y malignas de la cavidad bucal en pacientes remitidos a la consulta de máxilo facial, de la clínica estomatológica del policlínico “Luis Aldana Palomino”, durante el período comprendido entre enero de 2010 a diciembre de 2012, en el municipio Amancio. El universo de estudio estuvo constituido por 63 personas remitidas al referido servicio. La muestra quedó conformada por los 32 pacientes diagnosticados con lesiones malignas y premalignas. Las variables estudiadas fueron: edad, sexo, tipo de lesión, factores de riesgo y localización anatómica de las mismas. Predominaron los pacientes del grupo de edad de 35-59 años, del sexo masculino, así como la lesiones premalignas; se comprobó que la totalidad de las lesiones malignas fueron carcinomas epidermoides y la mayoría de las lesiones premalignas leucoplasias; el factor de riesgo predominante fue el hábito de fumar y las lesiones se encontraron localizadas fundamentalmente en el labio inferior

  13. Evaluación clínica de la salud oral de niños con neoplasias malignas Clinical Assessment of Oral Health of children with Malignant Neoplasm

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    MA Gordón-Núñez

    2005-06-01

    Full Text Available Objetivo: Este estudio de carácter descriptivo visó evaluar clínicamente niños con neoplasias malignas y poner de manifiesto la relación entre el status de salud bucal y la ocurrencia de complicaciones estomatológicas. Pacientes y métodos: la salud bucal de 40 niños con neoplasias malignas (grupo I fue evaluada clínicamente mediante examen físico extra e intra oral, obtención del índice de placa visible, índice de sangrado gingival e índice de dientes cariados, ausentes y obturados y simultáneamente fueron observadas las complicaciones estomatológicas desarrolladas en esos pacientes. El status de salud bucal de éstos niños fue comparado al de niños saludables (grupo II. Resultados: los niños del grupo I presentaron índices de sangrado gingival y experiencia de caries menores que los del grupo II, por otro lado, el índice de placa visible fue ligeramente mayor en los niños del grupo I, sin embargo, sólo hubo diferencia estadísticamente significativa en el valor del CAO-D/cao-d entre ambos grupos (p = 0.002. En el grupo I, 16 niños desarrollaron conjuntamente 61 complicaciones estomatológicas, con predominancia de la mucositis, seguida del sangrado oral espontáneo, candidiasis y xerostomia. Conclusión: Pacientes bajo tratamiento antineoplásico, presentando higiene oral deficiente, tienen mayor riesgo de desarrollar complicaciones estomatológicas.Objective: In this descriptive study were assessment clinically children with malignant neoplasm, to evidence the correlation between oral health status and the occurrence of stomatologic complications. Patients and methods: Were evaluated the oral health conditions of 40 children with malignant neoplasm (group I through intra and extra oral physic examination, obstention of Visible Plate Index, Gingival Bleeding Index and Decayed, Missed and Filled Teeth Index; simultaneously were observed the stomatologic complications developed in this patients. The oral health status of

  14. Avaliação do uso de extrato de timo (timulina em pacientes com neoplasia maligna submetidos ao tratamento cirúrgico

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    Célia Regina de Oliveira Garritano

    Full Text Available OBJETIVO: Avaliar a ação da timulina em pacientes com neoplasia maligna, submetidos ao tratamento, com e sem quimioterapia e radioterapia complementar (QT/RT. MÉTODO: Estudo retrospectivo realizado em 50 pacientes, analisando as variações das taxas de leucócitos, linfócitos totais e da relação de linfócitos CD4/CD8 após imunoestimulação com timulina. RESULTADOS: No grupo submetido à QT/RT ocorreu um aumento do número de leucócitos após seis meses em 43,33% dos casos, e em 83,33% após 12 meses. Com relação aos linfócitos totais, após seis meses, 63,33% apresentaram níveis maiores, e depois de 12 meses isto ocorreu em casos 90% dos casos. A relação de linfócitos CD4/CD8 mostrou um aumento em 66,66%, e em 90% depois após 6 e 12 meses respectivamente. A análise estatística se mostrou significante com o teste de ANOVA one way. No grupo não submetido à QT/RT a elevação dos níveis de leucócitos ocorreu em 85% dos pacientes aos seis meses e em 90% aos 12 meses. As taxas de linfócitos se elevaram em 60% dos casos em seis meses e em 85% após 12 meses. A relação CD4/CD8 se tornou maior tanto aos seis como aos 12 meses em 65%. A análise estatística mostrou relevância com o teste "t" de Student e o de ANOVA one way. Não houve necessidade de interrupção dos ciclos de QT/RT e nenhum paciente referiu intolerância à timulina. CONCLUSÃO: O uso da timulina foi capaz de restaurar a resposta imune, reduzir os danos imunossupressores e colaterais induzidos pela terapia antineoplásica e não apresentou efeitos colaterais.

  15. Patología maligna tiroidea. Hospital Sabogal, Callao

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    Juan Oré

    2004-03-01

    Full Text Available Objetivos: Determinar las características clínicas del cáncer de tiroides encontrados en la población del Callao. Diseño: Estudio descriptivo retrospectivo. Material y Métodos: Se revisó las historias clínicas de las intervenciones quirúrgicas de la glándula tiroides en el Hospital Nacional Alberto Sabogal Sologuren (HNASS, en el periodo enero de 2000 a diciembre de 2002, cuyo resultado por anatomía patológica fue compatible con neoplasia maligna de dicha glándula. Resultados: Las 45 neoplasias malignas primarias de tiroides encontradas representaron 34,2% de la patología tiroidea operada en el periodo en estudio. El carcinoma papilar se presentó en 100% de los pacientes de sexo masculino y en 82% del sexo femenino; en la mujer, los carcinomas folicular, medular y linfoma representaron 10,3%, 5,1% y 2,6%, respectivamente. El grupo etáreo con mayor incidencia fue entre 50 y 69 años, con una edad promedio de 53 años. Dentro de los diferentes tipos de neoplasias malignas, el más frecuente fue el papilar con 38 casos (84,4%, seguido de los carcinomas folicular y medular con 8,9% y 4,4%, respectivamente. El síntoma más frecuente fue el aumento de volumen (61,5%, seguido de dolor (15,4%, disfagia (10,8% y disfonía (9,2%; 29,6% se encontraba en estadio I y 59,1% en estadio II; sólo 11,4% estaba en estadio III. Conclusiones: El predominio de casos en mujeres del carcinoma papilar y la clínica asociada, fueron acordes con lo descrito en la literatura.

  16. Contribución al Estudio de las Distrofias Malignas en la Infancia.

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    Vidal Jiménez, Manuel

    2016-01-01

    1. Para esta Tesis hemos recogido 100 casos, que presentamos en protocolo anexo, procedentes todos de la Clínica universitaria de Pediatría de la Universidad de Sevilla, si bien para las estadísticas generales hemos recurrido a la totalidad de los casos (463) observados en dicho centro desde octubre de 1953 a junio de 1959. 2. El resto de las historias las desechamos fundados en los motivos siguientes: (a) Historias poco detalladas por ser obtenidas no de los familiare...

  17. Análise das oportunidades de diagnóstico precoce para as neoplasias malignas de mama An analyze the opportunities of early detection of breast cancer

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    Luciana Molina

    2003-06-01

    Full Text Available OBJETIVOS: O estudo procurou identificar e analisar as oportunidades de diagnóstico precoce para neoplasias malignas de mama, disponíveis para as mulheres do município de Botucatu. MÉTODOS: Foram entrevistadas por telefone, segundo sorteio aleatório, 261 mulheres com idade de 30 anos ou mais. RESULTADOS: A média de idade foi de 51 anos e 49,45% das entrevistadas apresentaram escolaridade de nove anos ou mais; 80% receberam orientações gerais sobre prevenção do câncer de mama e 86,9% orientações específicas sobre autopalpação; 78,9% das mulheres realizaram o auto-exame das mamas e destas somente 27% o fizeram corretamente. O exame clínico das mamas foi realizado em 76,2% das entrevistadas e a mamografia em 35,6%; se o exame de mamografia fosse solicitado por médicos e estivesse disponível, 83,1% das mulheres estariam dispostas a realizá-lo. CONCLUSÃO: A prevalência e a mortalidade da doença são maiores nas mulheres idosas. Neste estudo observou-se que estas apresentaram uma taxa menor de oportunidades de diagnóstico precoce, pois eram menos informadas sobre a periodicidade correta da autopalpação e apresentaram uma menor freqüência de mamografia e de exame clínico das mamas do que as mais jovens. O grau de escolaridade mostrou também significância estatística, visto que as mulheres com mais anos de estudo tiveram melhores oportunidades do que as com pouco estudo.PURPOSE: The study tried to identify and to analyze the opportunities of early detection of breast cancer available for the women of Botucatu County. METHODS: A sample of 261 women, 30 year-old or more was interviewed by telephone. RESULTS: The age average was of 51 years; 49.45% of them studied at least 9 year; 80% received general orientations about breast cancer prevention and 86,9% specific orientations on self breast exam; 78.9% of the interviewers made the self breast exam, but only 27% made it correctly. The physician breast examination was made in

  18. Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León Neoplasias primarias malignas múltiples en pacientes con cáncer gástrico en el área sanitaria de León

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    A. Muela Molinero

    2006-12-01

    Full Text Available Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26% and urologic (21%; 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.Objetivos: analizar las características de los pacientes con tumores gástricos diagnosticados de una neoplasia primaria maligna múltiple (NPMM en el área sanitaria de León. Pacientes y método: utilizando los datos del Registro de Tumores del Hospital de León se han seleccionado aquellos pacientes con tumores gástricos diagnosticados entre 1993 y 2002. Se realizó un seguimiento hasta el 31 de diciembre de 2004 analizando las características de los pacientes diagnosticados de una segunda neoplasia durante el periodo de seguimiento. Resultados: la prevalencia de NPMM fue del 1,96%. El 56% de los pacientes tenían antecedentes oncológicos en familiares de primer grado. Las segundas neoplasias más frecuentes fueron las digestivas (26% y las urológicas (21%. El 87% de los pacientes fueron

  19. Estudo histoquímico de proteínas fibrilares da matriz extracelular em neoplasias mamárias benignas e malignas na espécie canina

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    Ana Maria Cristina Rabello Pinto da Fonseca Martins

    2002-01-01

    Full Text Available A finalidade do presente trabalho foi estudar algumas das proteínas fibrilares da matriz extracelular de 54 neoplasias mamárias benignas e malignas na espécie canina, utilizando métodos histoquímicos: Picrosirius associado à polarização para fibras colágenas , método de Gordon - Sweats para fibras reticulares e método de Weigert com e sem oxidação para fibras elásticas. Evidenciou-se na matriz uma grande variabilidade na quantidade, distribuição e características dos componentes matriciais presentes nos diferentes tipos de neoplasias. Detectou-se, assim, colágeno I, III e elementos do sistema elástico, distribuídos diferentemente nas neoplasias benignas e malignas. O método Picrosirius simples e associado à polarização permitiu a visualização do colágeno sob a forma de fibras espessas distribuídas irregularmente no estroma dos carcinomas e de modo mais ordenado e regular nas neoplasias benignas e, fibras mais finas, em menor quantidade, irregularmente e aleatoriamente dispostas nos carcinomas e regularmente nas neoplasias benigna. Sob luz polarizada os feixes de fibras colágenas , apresentaram diferentes comprimentos, avermelhados ou amarelados e fortemente birrefringentes, sugerindo serem colágeno tipo I e, entremeando as fibras, algumas mais finas ,pálidas, esverdeadas e fracamente birrefringentes, presumivelmente colágeno tipo III. Em áreas condrometaplásicas, tanto nos carcinomas como nas neoplasias benignas notou-se que os feixes colágenos apresentavam-se com fibras finas, paralelas, limitando regiões estreitas onde os condrócitos se aninhavam, e, rodeando esta área, feixes de fibras espessas, anastomosadas, dispostas irregularmente nos carcinomas e ordenadamente e paralelas nas neoplasias benignas. Sob luz polarizada, essa população entre condrócitos era formada por fibras pálidas e amareladas, sugerindo padrão tipo II e na faixa circundante, feixes fortemente birrefringentes, sugerindo o padr

  20. Influência da transfusão sanguínea no desenvolvimento de infecção em pacientes com neoplasias malignas do sistema digestório Influence of blood transfusion on development of infection in patients with malignant neoplasms of the digestive system

    OpenAIRE

    Luiz Ronaldo Alberti; Leonardo de Souza Vasconcellos; Andy Petroianu

    2006-01-01

    RACIONAL: A anemia afeta mais de 90% dos pacientes com câncer e mais de 60% são submetidos a transfusões sangüíneas durante ou após o tratamento. OBJETIVO: Determinar a influência da transfusão sangüínea homógena como possível fator relacionado à infecção em paciente com neoplasia maligna do sistema digestório. MÉTODO: Avaliaram-se aleatoriamente prontuários de 400 pacientes com neoplasia maligna do sistema digestório, distribuídos em dois grupos: grupo 1 (n = 200) - pacientes transfundidos e...

  1. El diagnóstico por la imagen de las enfermedades de las glándulas salivales

    OpenAIRE

    Paz Expósito, Francisco

    2002-01-01

    Las lesiones de las glándulas salivales son relativamente frecuentes, presentando una patología tan diversa como la de cualquier otro sistema orgánico. La mayoría de las lesiones son inflamatorias, otras son de origen litiásico, algunas tienen una patogenia incierta que pueden confundirse con neoplasias malignas y, por último, hay un amplio espectro de neoplasias tanto benignas como malignas. La mayoría de los agrandamientos de las glándulas salivales están causados por procesos inflamator...

  2. Neoplasias de Cavidad nasal y senos paranasales en caninos

    OpenAIRE

    Giovanni Torres; Sandra Rodríguez

    2008-01-01

    Las neoplasias de cavidad nasal y senos paranasales en caninos son de escasa presentación; llegan tan sóloal 1.5% de los quistes diagnosticados en esta especie.Con referencia al total de tumores del tracto respiratorio representan entre el 60 y el 80%. Son más comunes en caninos de nariz larga, no existe predilección por género; por el comportamiento, las neoplasias que se desarrollanen la cavidad nasal y senos paranasales son benignas y malignas, siendo estas últimas las más frecuentes. Teni...

  3. Neoplasias de Cavidad nasal y senos paranasales en caninos

    OpenAIRE

    Giovanni Torres; Sandra Rodríguez

    2008-01-01

    Las neoplasias de cavidad nasal y senos paranasales en caninos son de escasa presentación; llegan tan sóloal 1.5% de los quistes diagnosticados en esta especie.Con referencia al total de tumores del tracto respiratorio representan entre el 60 y el 80%. Son más comunes en caninos de nariz larga, no existe predilección por género; por el comportamiento, las neoplasias que se desarrollanen la cavidad nasal y senos paranasales son benignas y malignas, siendo estas últimas las más frecuentes. Teni...

  4. Factores pronósticos en neoplasias malignas primarias de glándulas salivares: Estudio retrospectivo de 20 años Prognostic factors in primary malignant salivary gland neoplasms: A 20-year retrospective study

    Directory of Open Access Journals (Sweden)

    A. Capote Moreno

    2005-10-01

    Full Text Available Objetivo. Analizar los posibles factores pronósticos que pueden influir en la supervivencia y el desarrollo de recurrencias en nuestra serie de pacientes con neoplasias malignas primarias de glándulas salivares. Diseño del estudio. Se realiza un estudio retrospectivo de 75 pacientes con carcinomas glandulares tratados entre 1980 y el 2003. En todos los casos el tratamiento realizado ha sido la cirugía. Se administró radioterapia postoperatoria en un 52% de los pacientes. Se emplea el modelo de Kaplan-Meier para el análisis de supervivencia y el periodo libre de enfermedad. Así mismo, se analiza la posible asociación entre los diversos factores pronósticos y estas variables mediante el test Log Rank para el estudio univariante y el modelo de Cox para el multivariante. Resultado. La supervivencia global y causa-específica de la serie a 5 y 10 años ha sido del 74,9 y 63 y del 77,7 y 65,3% respectivamente. El periodo libre de enfermedad ha sido de 51,8 y 43,2% a 5 y 10 años. De los factores analizados, la localización tumoral, el sexo, el estadio patológico, el tamaño tumoral, la parálisis facial, la infiltración perineural y la infiltración vascular han mostrado una influencia estadísticamente significativa en la supervivencia y/o recurrencias (pObjective. To analyze the possible prognostic factors for survival and disease-free survival in a group of patients with primary malignant salivary gland tumors. Design. Seventy-five patients with salivary gland carcinomas were studied retrospectively from 1980 to 2003. All cases were initially treated with surgery. Postoperative radiotherapy was applied in 52% of the patients. Survival and disease-free survival were analyzed with the Kaplan-Meier method. The association between the different prognostic factors and survival was studied with the Log Rank test for univariate analysis and the Cox proportional model for multivariate analysis. Results. The 5-year and 10-year crude survival

  5. Otitis externa maligna

    OpenAIRE

    2014-01-01

    La otitis externa maligna es una enfermedad cuyo diagnóstico y tra- tamiento supone un reto para cualquier especialista. Es una infección severa que afecta al conducto auditivo externo (óseo/cartilaginoso) y a los tejidos blandos adyacentes. Suele afectar a pacientes inmuno- comprometidos y la diabetes mellitus es condición asociada hasta en 65% de los casos. En la mayoría de los casos el agente causal es la Pseudomonas aeruginosa. El diagnóstico debe basarse en historia clínica y exploración...

  6. Epidemiología de las neoplasias linfoides. Incidencia atribuible al SIDA

    OpenAIRE

    Marcos-Gragera, Rafael

    2006-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada En los últimos 20-30 años se ha descrito una aumento significativo de la incidencia de las neoplasias linfoides, si bien las causas de dicho incremento no son del todo conocidas, parece que la mejora diagnóstica de dichas enfermedades y la epidemia del SIDA han contribuido en parte a la creciente incidencia reportada recientemente, pero en la gran mayoría de los casos los factores de riesgo son aún desconocidos. Los obje...

  7. Sobre a nefrosclerose maligna

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    Hilde Adler

    1941-01-01

    Full Text Available 1º - Das aus den oeffentlichen Krankenhäusern von Rio de Janeiro stammende Sektionsmaterial umfasst einen beträchtlichen Prozentzatz von Individuen schwarzer und gemischter Rasse. Es besteht durchweg aus Angehörigen der sozial und oekonomisch niedersten Bevölkerungsschichten der Stadt und ihrer Vororte, die gemessen am Standard der Gesamtbevölkerung unter den dürftigsten hygienischen Bedingungen leben. So fanden sich unter 212 Autopsien aus dem Anfall der Pathologisch-Anatomischen Abteilung des Institutes Oswaldo Cruz im Jahr 1920 bei 111 Fällen schwarze oder Mischlinsfarbe protokolliert, (52,3%. Unter 349 Sektionen der gleichen Abteilung im Jahr 1938 waren 184 (= 52,7% von Individuen von schwarzer oder gemischter Rasse. Ein derartiges Material bietet guenstige Bedingungen fuer die Untersuchung der Bedeutung der Rassenzugehoerigkeit als aetiologischem und pathogenem Faktor fuer bestimmte Affektionen, bei welchen sie in der Literatu in diesem Sinn angeführt worden ist. 2º - Unter 1080 Sektionen von Indiduen männlichen Geschlechts jeder Altersstufe aus dem Material der gleichen Abteilung der Jahre 1918-1926 fanden sich bei 214 Faellen syphilitische Befunde protokolliert. (19,8% der Faelle. 129 (12% wiesen eine Aortitis oder Arteritis syphilitica auf. 3º - Das histologische Material einer Serie von 528 Autopsien von Individuen im Alter unter 40 Jahren wurde auf das Vorkommen der fuer Nephrosclerose maligna (FAHR typisch erachteten pathologischen Veraenderungen untersucht. Es wurden 4 Faelle festgestellt, die das Bild dieser Nephropathie zeigten. Unter den 528 Individuen dieser Gruppe waren 244 Weisse, (46,2% 274 Schwarze oder Mischlinge (51,8% Bei 10 war die Rassenzugehoerigkeit nicht ersichtlich. 4º - Unter Heranziehung von 6 weiteren Faellen aus anderen Serien von Sektionen der letzten 4 Jahre beläuft sich die Gesamtzahl der mikroskopisch festegestellen Faelle von Nephrosclerose maligna unter dem Material der Pathologisch

  8. Interacción de la proteína-tirosina fosfatasa SHP-1 y la proteína-tirosina kinasa FLT3 constitutivamente activada en las enfermedades malignas mieloides: Un nuevo factor pronóstico.

    OpenAIRE

    Mena Durán, Armando V.

    2008-01-01

    La búsqueda de factores pronósticos que permitan entender la heterogeneidad en laevolución de los pacientes diagnosticados de neoplasias mieloides ha dado paso a ladenominada "terapia adaptada al riesgo". Un buen ejemplo de ello son las mutacionesque afectan al dominio transmembranoso (ITD) y el dominio tirosina cinasa (D835) delreceptor de superficie celular de las células hematopoyéticas fms-like 3 (FLT3) queconstituye un conocido factor pronóstico en las leucemias aguda mieloblásticas (LMA...

  9. Interacción de la proteína-tirosina fosfatasa SHP-1 y la proteína-tirosina kinasa FLT3 constitutivamente activada en las enfermedades malignas mieloides: Un nuevo factor pronóstico.

    OpenAIRE

    Mena Durán, Armando V.

    2008-01-01

    RESUMEN La búsqueda de factores pronósticos que permitan entender la heterogeneidad en la evolución de los pacientes diagnosticados de neoplasias mieloides ha dado paso a la denominada terapia adaptada al riesgo. Un buen ejemplo de ello son las mutaciones que afectan al dominio transmembranoso (ITD) y el dominio tirosina cinasa (D835) del receptor de superficie celular de las células hematopoyéticas fms-like 3 (FLT3) que constituye un conocido factor pronóstico en las leucem...

  10. Interacción de la proteína-tirosina fosfatasa SHP-1 y la proteína-tirosina kinasa FLT3 constitutivamente activada en las enfermedades malignas mieloides: Un nuevo factor pronóstico.

    OpenAIRE

    Mena Durán, Armando V.

    2008-01-01

    RESUMEN La búsqueda de factores pronósticos que permitan entender la heterogeneidad en la evolución de los pacientes diagnosticados de neoplasias mieloides ha dado paso a la denominada terapia adaptada al riesgo. Un buen ejemplo de ello son las mutaciones que afectan al dominio transmembranoso (ITD) y el dominio tirosina cinasa (D835) del receptor de superficie celular de las células hematopoyéticas fms-like 3 (FLT3) que constituye un conocido factor pronóstico en las leucem...

  11. Acantosis Nigricans Maligna Acanthosis Nigricans Maligna

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    C Vallejo

    2011-06-01

    Full Text Available Es un síndrome paraneoplásico poco común, que se asocia a tumores gastrointestinales, más frecuentemente a adenocarcinoma gástrico (69%. Afecta a ambos sexos y no tiene prevalencia por grupo étnico alguno. Clínicamente son lesiones hiperpigmentadas, hipertróficas y verrucosas en zonas de flexión y en la mayoría de los casos, las mucosas también resultan afectadas con lesiones papilomatosas. Habitualmente desaparecen con la eliminación del tumor o reaparecen con la recurrencia o metástasis.Acanthosis nigricans malignant is an uncommon paraneoplastic syndrome associated with gastrointestinal tumors, frequently gastric adenocarcinoma, affects both sexes and it has not prevalence by race. Clinically, lesions are hyperpigmented, hypertrophic and verrucous in flexion areas and in most cases the mucous membranes are also affected with papillomatous lesions. Tipically disappears with the removal of the tumor and reappears when recurrence or metastasis occur.

  12. Image and Histologic Characterization of Intracranial Neoplasias Caracterización tomográfica e histológica de las neoplasias intracraneales

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    Carlos Rafael Rivera Prieto

    2011-04-01

    Full Text Available Background: In Cuba, as in all developed countries, cancer is the second cause of death and among it the different types of intracranial neoplasms present a morbidity of 2-3 %. Among the diagnostic methods that can be used computarized tomography (CT-Scan and magnetic resonance image (MRI are the techniques that define the patient’s diagnosis and treatment in this type of neoplasm. Objective: to characterize intracranial neoplasm. Methods: a retrospective descriptive study that included the discharged patients operated from central nervous system neoplasms was carried out at the University General Hospital “Dr. Gustavo Aldereguía Lima” from Cienfuegos province, from January 1st, 2003 to December 31st , 2007. All the patients had undergone a computarized tomography and had the histological post operatory diagnosis of primary or secondary neoplasms of the intracranial central nervous system. The variables under study were: sex, age, symptoms, location of the tumor, histological diagnosis, and tomography variables. Results: Neoplasms were predominant in males and in patients between 40 - 59 years of age. The most frequent symptom was headache, and its location in the frontal - parietal area. In 85, 7 % of the metastases a hypodense image was observed meanwhile in meningiomas a hyperdense image was seen. All tumors increased their density after contrast administration. The tomographic diagnosis coincided with the histological one in 85,7 % of gliomas, in 80 % of meningiomas and in 40 % of metastases. Conclusion: The computarized images of the cranium allow the inference of the histological type of intracranial neoplasms.Fundamento: en Cuba, al igual que en la mayoría de los países desarrollados, el cáncer ocupa la segunda causa de muerte y dentro de este, las neoplasias intracraneales tienen una morbilidad del 2-3 %. Entre los métodos de

  13. Simultaneous appearance of two malignant neoplasias in a 25 year-old woman. A case presentation. Aparición simultánea de dos neoplasias malignas en una mujer de 25 años. Presentación de un caso.

    Directory of Open Access Journals (Sweden)

    Miryam González González del Pino

    Full Text Available Lung cancer and cervix uterine cancer appear in an independent way in women worldwide and both are frequently on them. However, these neoplasias are rarely presented in association. In the medical reviewed literature this association with a primary character has not been found. Thus, a 25 year-old woman who was diagnosed with both diseases is the case we would like to present to you.

    El cáncer de pulmón y el cérvico- uterino inciden de manera independiente en la mujer a nivel mundial y ambos son frecuentes en ellas, sin embargo estas neoplasias casi nunca se presentan asociadas. En la literatura revisada no hemos encontrado recogida dicha asociación, con un carácter primario. Por tal motivo presentamos el caso de una mujer de 25 años, a la que se le diagnosticó ambas enfermedades.

  14. Ressonância magnética para avaliação dos limites dos campos clássicos de radioterapia em pacientes portadoras de neoplasia maligna de colo uterino Magnetic resonance imaging in the evaluation of standard radiotherapy field borders in patients with uterine cervix cancer

    Directory of Open Access Journals (Sweden)

    Geison Moreira Freire

    2010-06-01

    Full Text Available OBJETIVO: Avaliar os limites de campo padronizados para radioterapia de neoplasia maligna de colo uterino com o uso de ressonância magnética e verificar a importância deste exame na redução de possíveis erros de planejamento com técnica convencional. MATERIAIS E MÉTODOS: Foram analisados, retrospectivamente, exames de ressonância magnética do planejamento de 51 pacientes tratadas devido a neoplasia de colo uterino. Os parâmetros estudados foram limites anterior e posterior no corte sagital. RESULTADOS: Observou-se, no corte sagital das ressonâncias magnéticas, que o limite de campo anterior apresentou-se inadequado em 20 (39,2% pacientes e que houve perda geográfica em 37,3% dos casos no limite posterior. A inadequação de ambos os limites de campo não se relacionou com parâmetros clínicos como idade das pacientes, estadiamento, tipo e grau histológico. CONCLUSÃO: A avaliação dos limites de campo padronizados pela literatura com o uso de ressonância magnética mostrou altos índices de inadequação dos limites do campo lateral, assim como a importância do uso deste exame no planejamento radioterápico de pacientes portadoras de câncer de colo uterino com a finalidade de reduzir a perda geográfica no volume alvo de tratamento.OBJECTIVE: To evaluate, by means of magnetic resonance imaging, the standardized field borders in radiotherapy for malignant neoplasm of uterine cervix, and to determine the role of this method in the reduction of possible planning errors related to the conventional technique. MATERIALS AND METHODS: Magnetic resonance imaging studies for planning of treatment of 51 patients with uterine cervix cancer were retrospectively analyzed. The parameters assessed were the anterior and posterior field borders on sagittal section. RESULTS: The anterior field border was inappropriate in 20 (39.2% patients and geographic miss was observed in 37.3% of cases in the posterior border. The inappropriateness of both

  15. Efectos sobre las células pleurales malignas de la hipertermia y cisplatino: síntesis de proteínas pro-inflamatorias y apoptosis celular

    OpenAIRE

    2016-01-01

    En razón de su elevada incidencia y mal pronóstico, la infiltración neoplásica maligna de la pleura supone un importante reto terapéutico en la actualidad, dado que los resultados de los tratamientos disponibles son pobres y en la mayor parte de los casos únicamente implican el control de síntomas. El empleo de la quimioterapia hipertérmica intrapleural podría aportar un mejor control de la enfermedad mejorando la supervivencia y calidad de vida de los pacientes. A pesar de que en los últimos...

  16. Utilidad de la perfusión por resonancia magnética con contraste potenciada en T1 en la valoración de la Neoplasias de SNC y cambios inducidos en la médula ósea de columna vertebral

    OpenAIRE

    Arévalo Pérez, Julio

    2016-01-01

    Las fracturas vertebrales por compresión en la columna torácica o lumbar son un problema común en la práctica clínica diaria, sobre todo en pacientes de edad avanzada. La osteoporosis es la causa más común de fracturas por compresión en este grupo de edad. Sin embargo, la columna vertebral es también un lugar frecuente de metástasis y neoplasias primarias que pueden resultar en fracturas patológicas. Por lo tanto, diferenciar entre las fracturas de etiología maligna de las fracturas benignas ...

  17. Neoplasias de Cavidad nasal y senos paranasales en caninos

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    Giovanni Torres

    2008-10-01

    Full Text Available Las neoplasias de cavidad nasal y senos paranasales en caninos son de escasa presentación; llegan tan sóloal 1.5% de los quistes diagnosticados en esta especie.Con referencia al total de tumores del tracto respiratorio representan entre el 60 y el 80%. Son más comunes en caninos de nariz larga, no existe predilección por género; por el comportamiento, las neoplasias que se desarrollanen la cavidad nasal y senos paranasales son benignas y malignas, siendo estas últimas las más frecuentes. Teniendo en cuenta el tejido de origen pueden ser epiteliales, mesenquimales y de otro origen como los linfomas y el tumor venéreo transmisible. La apariciónde la sintomatología se asocia con la capacidad de obstruir las vías aéreas, la invasión y destrucción local de tejido. En general los signos clínicos asociados consistenen: dificultad respiratoria, estornudo, secreciónnasal, hemorragia nasal y la presencia de masas de características variadas en tamaño y forma. El diagnóstico se basa en signos clínicos, evaluación citológica e histológica de las lesiones. Esta última es 100% diagnóstica, para el tratamiento se utiliza la extracción quirúrgica combinada con terapia de radiación y quimioterapia.

  18. Susceptibilidade à hipertermia maligna em três pacientes com síndrome maligna por neurolépticos

    OpenAIRE

    Silva,Helga C.A.; Bahia,Valéria S.; de Oliveira, Rogério A A; Paulo E. Marchiori; MILBERTO SCAFF; TSANACLIS,ANA MARIA C.

    2000-01-01

    A hipertermia maligna caracteriza-se por hipertermia, rigidez muscular, rabdomiólise, acidose e insuficiência de múltiplos órgãos. A hipertermia maligna anestésica decorre da exposição a halogenados e/ou relaxantes musculares despolarizantes. O método padrão para diagnosticar a suscetibilidade à hipertermia maligna é o teste da contratura muscular in vitro em resposta ao halotano e à cafeína. A síndrome maligna por neurolépticos caracteriza-se por hipertermia, síndrome extrapiramidal, acidose...

  19. Histiocitosis maligna: Reporte de un caso

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    Oscar Ruiz

    2004-12-01

    Full Text Available Paciente varón de 14 años, procedente de Huancayo, que presenta un mes antes de su hospitalización intolerancia gástrica, ictericia, fiebre y síndrome linfoproliferativo. Se encontró en los exámenes de laboratorio pancitopenia severa por hemofagocitosis. El diagnóstico hematológico y anatomopatológico fue histiocitosis maligna. Se presenta este caso por ser una entidad infrecuente y una emergencia médica.

  20. Caracterización del mieloma múltiple y de su componente monoclonal durante 14 años en Las Tunas

    OpenAIRE

    Olga Lina Pupo Rodríguez; María M. Bello Rodríguez; Rogelio Pérez Rivero; Mario C. Vázquez Carmenate

    2015-01-01

    El mieloma múltiple es una neoplasia de células plasmáticas que representa el 10% de las enfermedades hematológicas malignas. La mayoría de los pacientes presentan síntomas, signos y trastornos de laboratorio sugestivos de enfermedad activa, incluyendo lesiones osteolíticas activas, hipercalcemia, anemia y fallo renal. Para el diagnóstico de esta enfermedad hay que tener en cuenta las manifestaciones clínicas, los estudios radiológicos, pruebas especiales como citología celular y exámenes de ...

  1. Seguimiento de un fibroma ameloblástico con transformación maligna a fibrosarcoma ameloblástico.

    OpenAIRE

    Galindo Obando, Ursula; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Delgado Azañero, Wilson; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima.; Calderón Ubaqui, Víctor; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Beltrán Silva, Jorge; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Huamaní Parra, Jaime; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima.; Paniura Rodriguez, Dithel; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Anchayhua Espinoza, Miguel; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    La transformación maligna de un tumor odontogénico es poco común y puede desarrollarse a partir de un tumor odontogénico benigno. Se presenta el caso de una paciente de sexo femenino de 19 añosde edad, con el seguimiento secuencial de las radiografías y tomografía computarizada de una lesión inicialmente diagnosticada como Ameloblastoma, que posterior al tratamiento quirúrgico se establececomo Fibroma ameloblastico y al cabo de seis años sufre una transformación maligna determinado con un dia...

  2. Tratamiento de las neoplasias hematológicas en el embarazo Treatment of hematologic neoplasms during pregnancy

    OpenAIRE

    Norma E Tartas; María C Foncuberta; Julio C. Sánchez Avalos

    2007-01-01

    La neoplasia hematológica más frecuente en la mujer gestante es el linfoma de Hodgkin. Con menor frecuencia se han comunicado leucemias agudas o linfomas no Hodgkin (LNH). En los últimos años se han introducido nuevos fármacos que han cambiado el pronóstico de neoplasias como la leucemia promielocítica aguda, los linfomas no Hodgkin y la leucemia mieloide crónica. Se presenta aquí información actualizada sobre drogas y tratamientos, desarrollo de nuevos fármacos, mecanismo de acción, aplicaci...

  3. Modificação de dispositivo para gastrostomia endoscópica percutânea pela técnica de punção: utilização em pacientes com neoplasia maligna de cabeça e pescoço

    OpenAIRE

    José Humberto Giordano Nappi

    2009-01-01

    O câncer de cabeça e pescoço é a quinta neoplasia mais frequente nos países em desenvolvimento. A disfagia resultante da doença ou do tratamento pode levar à perda ponderal e à desnutrição. A nutrição enteral por sonda é o método de escolha para administração de terapia nutricional aos pacientes com trato gastrointestinal funcionante, incapazes de manter ingestão adequada por via oral. Sondas nasogástricas ou nasoenterais são empregadas para alimentação a curto prazo e sondas de gastrostomia ...

  4. Estudio prospectivo de la cefalea en pacientes con hemopatías malignas

    OpenAIRE

    Marín Lahoz, Juan; Roig Arnall, Carles

    2013-01-01

    Objetivo: describir las cefaleas en pacientes ingresados con neoplasias hematológicas, identificar los factores asociados a cefaleas secundarias graves. Estudio observacional prospectivo. Se incluyen 30 casos de cefalea correspondientes a 23 pacientes. Ocho cefaleas son primarias y 22 secundarias. Diez de estas, son secundarias a patología grave o potencialmente grave: encefalopatía hipertensiva, neoplasia intracraneal, hemorragia intracraneal, infección cefálica, trombosis venosa, fiebre tum...

  5. Ressecções eletiva e de urgência para tratamento de neoplasia maligna do cólon em hospital universitário: estudo de 66 casos Elective and urgency resections for the treatment of colon neoplasm in University Hospital: study of 66 cases

    Directory of Open Access Journals (Sweden)

    Marcelo Rodrigues Borba

    2011-06-01

    Full Text Available O câncer de cólon é uma doença de alta prevalência e mortalidade, cujo tratamento baseia-se na ressecção cirúrgica. A possibilidade de cura aumenta com o diagnóstico precoce, daí a importância dos programas de rastreamento populacional do câncer colorretal. O presente estudo analisou, retrospectivamente, 66 pacientes submetidos a ressecções do cólon por neoplasia em um período de 58 meses no Hospital Universitário da Universidade de São Paulo. Os pacientes foram divididos em dois grupos: grupo 1, submetidos a cirurgia eletiva (28 pacientes, e grupo 2, submetidos a cirurgia de urgência (38 pacientes. Os grupos foram comparados com relação às variáveis sexo, idade, apresentação clínica, aspectos da técnica cirúrgica, sítio anatômico da lesão, estádio patológico, taxas de complicações, permanência hospitalar pós-operatória e óbitos na internação. Verificou-se no presente estudo que a idade entre os grupos foi semelhante. Houve uma predominância do sexo masculino entre os pacientes operados de urgência. No grupo de cirurgia eletiva, o principal sintoma foi a hematoquezia, enquanto os operados na urgência, tinham como principal queixa dor abdominal. A grande maioria dos pacientes, no momento da cirurgia, apresentava-se sintomática há meses. Os pacientes operados na urgência apresentaram mais tumores pT4 e os operados eletivamente apresentaram mais neoplasias em estádio I. Em ambos os grupos, o caráter oncológico dos procedimentos foi preservado, bem como foi alto o índice de anastomoses primárias (81,8%. As taxas de complicações pós-operatórias, o tempo de permanência hospitalar pós-operatório e a mortalidade foram semelhantes.Colon cancer is a disease with high frequency and mortality rates, which treatment is based, fundamentally, on surgical resection. Because early diagnosis increases the curability, it is essential to have a screening programs offering early treatment. A retrospective

  6. Tratamiento de las neoplasias hematológicas en el embarazo Treatment of hematologic neoplasms during pregnancy

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    Norma E Tartas

    2007-12-01

    Full Text Available La neoplasia hematológica más frecuente en la mujer gestante es el linfoma de Hodgkin. Con menor frecuencia se han comunicado leucemias agudas o linfomas no Hodgkin (LNH. En los últimos años se han introducido nuevos fármacos que han cambiado el pronóstico de neoplasias como la leucemia promielocítica aguda, los linfomas no Hodgkin y la leucemia mieloide crónica. Se presenta aquí información actualizada sobre drogas y tratamientos, desarrollo de nuevos fármacos, mecanismo de acción, aplicación clínica, experiencias y resultados del tratamiento, efectos secundarios y teratogénicos, a fin de orientar a hematólogos, oncólogos y pediatras. El equipo médico debe ofrecer el tratamiento más eficaz disponible para alcanzar la curación o remisión de la enfermedad, e informar acerca de sus posibles riesgos para la madre y el feto, así como los derivados por la demora de su aplicación.The most common hematological malignancy in pregnant patients is Hodgkin's lymphoma, but other diseases such as chronic and acute leukemia or non Hodgkin's lymphoma have also been reported. In the last decade, new drugs have changed the prognostic of acute promyelocytic leukemia, chronic myeloid leukemia and non Hodgkin's lymphoma. Herein we present updated information on drugs and treatments, new developments, mechanism of action, clinical application, experience on treatment outcomes, adverse effects and teratogenesis, with the objective of orienting hematologists, oncologists and pediatricians. The medical team should offer the most efficient treatment available in order to achieve cure or remission of the disease, and also inform on possible risks for the mother and the fetus, as well as those derived from the delay in treatment application.

  7. Incidencia de neoplasias hematológicas en el Área Metropolitana de Bucaramanga, 2000-2004

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    Claudia Janeth Uribe Pérez

    2008-07-01

    Full Text Available Resumen SummaryAntecedentes: Las lesiones hematooncológicas son un grupo de neoplasias generadas por alteraciones células progenitoras hematopoyéticas. Este tipo de lesiones afectan a la población en general, con un porcentaje importante de ocurrencia en la población infantil. En el Área Metropolitana de Bucaramanga (AMB estos trastornos se ubican dentro de las lesiones malignas más frecuentes region (2000 - 2004. Metodología: El Registro Poblacional del AMB realiza un proceso de búsqueda y verificación IACR, activa de los casos de cáncer en la población residente AMB desde el 2000. Luego de los procesos de validación, los casos son codificados y digitados en CanReg-4 con el cual se estiman frecuencias y tasas de software. Este informe tiene datos verificados y actualizados que incluyen los obtenidos en el proceso de validación de egreso hospitalario y registros de mortalidad. Resultados: Entre 2000 y 2004 se captaron 620 casos de neoplasias hematolinfoides ubicándose en los primeros lugares tanto en hombres como en mujeres, con un mayor número de casos en los hombres especialmente por casos de leucemia linfoide. Se encuentra tasa cruda de 10.9 casos Conclusión: Comparando con las cifras del proyecto , el comportamiento de las neoplasias hematológicas en esta región es similar a lo estimado para el Área Metropolitana de Bucaramanga

  8. Trasplante de sangre cordón umbilical de donante no emparentado en adultos con enfermedades hematológicas malignas

    OpenAIRE

    Sanz Caballer, Jaime

    2013-01-01

    En los últimos años se ha producido un gran incremento de la actividad de trasplante de sangre de cordón umbilical (TSCU) en adultos. Diferentes estudios han demostrado que el TSCU es viable en pacientes adultos con enfermedades hematológicas malignas y se debe considerar como alternativa a la MO o SP de DNE adulto. Los objetivos de este trabajo de tesis doctoral fueron analizar los resultados terapéuticos de una amplia serie de pacientes adultos con neoplasias hematológicas sometidos a T...

  9. Estudio de las aneuplodías del cromosoma 17 y deleción del gen tp53 en neoplasias hematológicas por la técnica del fish-bicolor

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    Carlos Mario Muñetón Peña

    2008-12-01

    Full Text Available Las neoplasias hematológicas se caracterizan por presentar una amplia diversidad de alteraciones genéticas. Se analizaron 15 muestras de diferentes tipos de neoplasias hematológicas mediante el FISH, para detectar aneuplodías del cromosoma17 y la deleción del gen TP53. En 11 de las 15 muestras se realizaron análisis cromosómicos por citogenética convencional; 6 de las 11 muestras tenían cariotipo anormal (54.5%, se detectaron 3 translocaciones y 3 mosaicismos. Análisis de FISH en 15 muestras mostró un 26.7% de aneuplodía del cromosoma 17 y un 33.3% con deleción del gen TP53. De los 6 casos con cariotipo anormal, 2 tenían alteraciones por FISH. En 5 casos se detectaron alteraciones cromosómicas por FISH, las cuales no se observaron por citogenética convencional. Solo 3 (20% de las 15 muestras analizadas fueron normales para el análisis cromosómico por citogenética convencional y FISH. En este trabajo se corrobora que la aneuplodía del cromosoma 17 y la deleción del gen TP53 tienen una baja incidencia en las neoplasias hematológicas. Si embargo, el valor pronóstico de estas alteraciones genéticas no esta bien definido.

  10. Localización Inmunohistoquímica de las Proteínas Onco-Placentarias en las Neoplasias del Aparato Reproductor.

    OpenAIRE

    Parrilla Márquez, Antonino

    2016-01-01

    Durante los últimos veinte años se han descubierto un gran número de nuevas proteínas en la placenta humana. Inicialmente, fueron denominadas “Proteínas Placentarias”, ya que se pensaba, que eran sintetizadas exclusivamente por ésta. En la actualidad, las proteínas placentarias que denominaremos de “nuevas generación” por su reciente descubrimiento, se han clasificado en tres grandes grupos: 1.- Proteí...

  11. Neoplasia de colon

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    Alina Torreblanca Xiques

    2014-12-01

    Full Text Available El cáncer de colon es un tumor que se desarrolla por degeneración maligna de las células del intestino grueso, desde la válvula ileocecal hasta la flexura recto sigmoidea. Se presenta el caso de un paciente masculino, de 75 años, con astenia anorexia y pérdida de peso; al examen físico: mucosas hipocoloreadas, abdomen blando no doloroso a la palpación superficial ni profunda. Se palpa aumento de volumen a nivel de la fosa ilíaca derecha, fija, de consistencia dura, ruidos hidroaereos normales. Se realizaron exámenes hematológicos, radiológicos y endoscópicos para el diagnóstico. Se tuvo la confirmación diagnóstica por anatomía patológica de adenocarcinoma de colon derecho, bien diferenciado. Se aplicó tratamiento primario, consistente en una amplia resección quirúrgica del cáncer del colon y el drenaje linfático regional, posteriormente se aplicó quimioterapia. El paciente evolucionó satisfactoriamente

  12. Lues maligna in an HIV-infected patient

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    Passoni Luiz Fernando Cabral

    2005-01-01

    Full Text Available We report such a case of malignant syphilis in a 42-year-old HIV-infected man, co-infected with hepatitis B virus, who presented neurolues and the classical skin lesions of lues maligna. The serum VDRL titer, which was 1:64 at presentation, increased to 1:2,048 three months after successful therapy with penicillin, decreasing 15 months later to 1:8.

  13. Characterization of the hospitalization of children and adolescents with cancer Caracterización de las internaciones hospitalarias de niños y adolescentes con neoplasias Caracterização das internações hospitalares de crianças e adolescentes com neoplasias

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    Raquel Pan

    2011-12-01

    Full Text Available This study characterizes hospitalizations of children and adolescents with cancer, from 1998 to 2008, to describe the clientele in follow-up in the Regional Health Area of Ribeirão Preto, SP, Brazil. Morbidity was surveyed in Ribeirão Preto, SP, Brazil, using hospitalization data from the Unified Health System. The studied variables included: origin, residence, year when care was provided, deaths, age and gender of patients diagnosed with child and adolescent cancer according to the International Classification of Disease 10th edition, Chapter II. The results indicated 7,234 hospitalizations of individuals younger than 18 years old diagnosed with neoplasm, 95% of which were from Ribeirão Preto, SP, Brazil, and the remainder from cities located in all five of the Brazilian regions. Identifying the characteristics of patients contributes to the identification of information to broaden the sensitization of health professionals concerning the need for secondary preventive actions, such as early diagnosis.Este estudio tuvo por objetivo caracterizar las internaciones hospitalarias de niños y adolescentes con neoplasias, de 1998 a 2008, para conocer la clientela en seguimiento en la Regional de Salud de Ribeirao Preto, Sao Paulo, Brasil. Se realizó un levantamiento de la morbilidad en Ribeirao Preto, utilizando, como fuente de información, las internaciones hospitalarias por el Sistema Único de Salud. Las variables estudiadas fueron: procedencia, residencia, año de la atención, muertes, edad y sexo de los pacientes con diagnóstico de neoplasia infanto-juvenil, según el Capítulo II de la Clasificación Internacional de Enfermedades 10ª edición. Se constataron 7.234 internaciones de menores de 18 años con diagnóstico de neoplasias, de estas, 95% ocurrieron en Ribeirao Preto y las otras en municipios de procedencia pertenecientes a las cinco regiones del país. Conocer las características de la clientela atendida contribuye para

  14. Afectación y supervivencia renal en la hipertensión arterial maligna

    OpenAIRE

    González Fuentes, Roberto

    2012-01-01

    La hipertensión arterial maligna (HTAM) es la forma más grave de presentación de un paciente hipertenso. Los trabajos clásicos, realizados hace más de 4-6 décadas, mostraban una elevada tasa de mortalidad y de fallo renal permanente en los supervivientes. Algunos autores han sugerido una disminución de casos en las últimas décadas, así como un mejor pronóstico. No obstante, el número de trabajos relacionados con esta patología publicados en los últimos años es ciertamente escaso. Ten...

  15. Dermatologic symptoms associated with gastrointestinal neoplasia

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    Beata Młynarczyk-Bonikowska

    2017-03-01

    Full Text Available Gastrointestinal tumors are among the most common neoplastic causes of death worldwide. Presence of characteristic skin lesions can allow faster diagnosis and therapy and this way can increase the probability of a cure. In the paper we present the most important paraneoplastic syndromes that can coexist with gastrointestinal malignancy including colon, gastric, esophagus and pancreatic cancers. We take into account genetic syndromes such as Cowden syndrome, familial atypical multiple mole melanoma syndrome (FAMMM (melanoma/pancreatic cancer, Clarke Howel-Evans, Peutz-Jeghers, Muir-Torre, Gardner syndromes and acquired syndromes such as acantosis nigricans maligna, tripe palms, Leser-Trelat, Bazex, hypertrichosis languinosa, erythema gyratum repens , carcinoid and glucagonoma syndrome. We also include cutaneous metastases and coexistence of neoplasia in some cases of dermatomyositis.

  16. Interferón alfa-2b tópico como primera opción en las neoplasias intraepiteliales corneoconjuntivales Topical interferon alfa-2b for primary treatment of conjunctiva-cornea intraepithelial neoplasia

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    M. Pérez de Arcelus

    2012-04-01

    Full Text Available Se describen dos casos de neoplasia intraepitlelial corneo-conjuntival (CIN tratados con interferón alfa-2b (IFN alfa-2b tópico como primera elección. El tratamiento clásico de los CIN ha sido tradicionalmente la resección completa con márgenes de seguridad seguida de crioterapia en el lecho quirúrgico. No obstante, y puesto que la tasa de recidivas puede alcanzar el 50% han sido propuestos coadyuvantes como la mitomicina C y el 5 fluoracilo, con el consiguiente riesgo de toxicidad corneal y límbica. El IFN alfa-2b presenta una eficacia similar a la cirugía en la erradicación completa de la masa tumoral como primera opción, con escasos efectos secundarios y nulo potencial carcinogénico, incluso en casos de recurrencia a terapia con mitomicina C, lesiones quirúrgicas residuales y formas difusas.We describe two cases of conjunctival-cornea intraepithelial neoplasia (CIN, treated with topical IFN alfa 2b. The traditional treatment for CIN is surgical excision usually with adjunctive cryotherapy. However, residual tumour may remain, which can lead to recurrence rates of more than 50%. 5-Fluorouracil, mitomicyn C and interferon alfa 2b are new pharmacological agents that have proved their efficacy in the treatment of CIN. As side effects are common, we present IFN alfa 2b as a single therapeutic agent as an effective and optimal treatment for presumed recurrent corneal and conjunctival intraepithelial neoplasia. It offers the benefits of topical therapy and avoids the risks of surgical or other interventions - specifically, ocular surface toxicity, cicatricial conjunctival changes, and limbal stem cell deficiency.

  17. Interferón alfa-2b tópico como primera opción en las neoplasias intraepiteliales corneoconjuntivales Topical interferon alfa-2b for primary treatment of conjunctiva-cornea intraepithelial neoplasia

    OpenAIRE

    M. Pérez de Arcelus; Aranguren, M.; J. Andonegui

    2012-01-01

    Se describen dos casos de neoplasia intraepitlelial corneo-conjuntival (CIN) tratados con interferón alfa-2b (IFN alfa-2b) tópico como primera elección. El tratamiento clásico de los CIN ha sido tradicionalmente la resección completa con márgenes de seguridad seguida de crioterapia en el lecho quirúrgico. No obstante, y puesto que la tasa de recidivas puede alcanzar el 50% han sido propuestos coadyuvantes como la mitomicina C y el 5 fluoracilo, con el consiguiente riesgo de toxicidad corneal ...

  18. Schwannoma intercostal simulando neoplasia pulmonar

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    Henn L.A.

    1998-01-01

    Full Text Available Schwannoma é uma neoplasia mesenquimal, usualmente solitária, encontrada no mediastino, retroperitônio ou pelve, sendo rara sua apresentação na parede torácica. OBJETIVO: Relatar o caso de um paciente masculino, tabagista, com um nódulo pulmonar direito com características de malignidade, detectado em radiografia de tórax de rotina, cujo diagnóstico anatomopatológico foi de schwannoma benigno de nervo intercostal. MÉTODOS: Revisaram-se os dados referentes ao quadro clínico, exames laboratoriais e de imagem (radiografia e tomografia computadorizada de tórax do caso em estudo, assim como os exames anatomopatológico e imuno-histoquímico do espécime cirúrgico. RESULTADOS: O paciente foi submetido à toracotomia direita diagnóstica com ressecção da tumoração. O exame anatomopatológico convencional mostrou células tumorais de aspecto fusiforme, dispostas em paliçada, formando os corpos de Verocay, compatível com schwannoma intercostal. A imuno-histoquímica foi positiva para proteína S-100, vimentina e enolase, e negativa para neurofilamentos. CONCLUSÃO: O diagnóstico definitivo de schwannoma só é possível por meio da análise histopatológica e imuno-histoquímica da lesão. Seu aspecto celular, associado à atividade mitótica e a áreas de pleomorfismo, pode levar ao diagnóstico incorreto de malignidade. A imuno-histoquímica, por meio da proteína S-100, é útil na caracterização da benignidade da lesão, já que não é detectada nas lesões malignas. Os schwannomas de parede torácica podem simular neoplasias pulmonares na radiografia e tomografia computadorizada de tórax.

  19. Factores Sociodemográficos y Clínicos Asociados a la Recepción de Cuidado Informal en Pacientes con Neoplasia Hematológica: Estudio Basado en las Diferentes Etapas del Tratamiento

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    Marta Ortega - Ortega

    2015-01-01

    Full Text Available Los factores relacionados con la recepción de cuidado informal (CI en pacientes oncológicos es una cuestión poco estudiada. El objetivo fue analizar los factores sociodemográficos y clínicos asociados a la recepción de cuidado informal en pacientes con neoplasia hematológica a lo largo de las diferentes etapas del tratamiento. Métodos: 139 pacientes diagnosticados de neoplasia hematológica que recibieron un trasplante de células madre durante el período 2006-2011 en dos centros sanitarios españoles completaron la encuesta elaborada para el estudio. Se estimó un modelo de regresión logística binaria para cada una de las cuatro etapas de tratamiento: pretrasplante, primer año, segundo y tercer año, cuarto al sexto año postrasplante. La variable dependiente fue recibir o no cuidado informal. Resultados: Pacientes diagnosticados de leucemia aguda presentaron mayor probabilidad de recibir CI durante la etapa pretrasplante (OR=6,394 y durante el segundo y tercer año postrasplante (OR=42,212. A largo plazo (4º-6º año los pacientes con mieloma múltiple fueron los que requirieron mayor cuidado (OR=15,977. El estado de salud fue estadísticamente significativo en la mayoría de las etapas. Ser hombre (OR=0,263, tener pareja (OR=0,137 y estar empleado (OR=0,110 se asociaron a una menor probabilidad de recibir CI a largo plazo. Conclusiones: El CI está presente en más del 75% de los pacientes con neoplasia hematológica durante la etapa pretrasplante y primer año postrasplante. El diagnóstico y estado de salud son decisivos en la probabilidad de recibirlo, pero no el tipo de trasplante. Los factores sociodemográficos cobran protagonismo a largo plazo.

  20. Neoplasia célula T/natural killer

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    Pedro Gargantilla Madera

    2016-03-01

    Full Text Available Las neoplasias de células NK son poco frecuentes y de difícil diagnóstico. Presentamos el caso de un paciente con una neoplasia de célula NK que debutó como linfocitosis relativa asintomática.

  1. Clinical usefulness of reflectance confocal microscopy in the management of facial lentigo maligna melanoma.

    Science.gov (United States)

    Alarcón, I; Carrera, C; Puig, S; Malvehy, J

    2014-04-01

    Facial lentigo maligna melanoma can be a diagnostic challenge in daily clinical practice as it has similar clinical and morphological features to other lesions such as solar lentigines and pigmented actinic keratoses. Confocal microscopy is a noninvasive technique that provides real-time images of the epidermis and superficial dermis with cellular-level resolution. We describe 3 cases of suspected facial lentigo maligna that were assessed using dermoscopy and confocal microscopy before histopathology study. In the first case, diagnosed as lentigo maligna melanoma, presurgical mapping by confocal microscopy was performed to define the margins more accurately. In the second and third cases, with a clinical and dermoscopic suspicion of lentigo maligna melanoma, confocal microscopy was used to identify the optimal site for biopsy. Copyright © 2012 Elsevier España, S.L. and AEDV. All rights reserved.

  2. Manejo das neoplasias metastáticas da coluna vertebral - uma atualização

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    João Luiz Vitorino Araujo

    2013-12-01

    Full Text Available O aumento da sobrevivência do paciente oncológico decorrente da melhoria e do avanço das modalidades terapêuticas promove progressivo aumento da prevalência das neoplasias metastáticas da coluna vertebral, tornando o seu conhecimento condição sine qua non para os profissionais da área de saúde. As metástases na coluna vertebral são usualmente procedentes de neoplasia maligna da mama, pulmão e próstata, o gênero masculino é o mais acometido e a dor é o sintoma inicial em mais de 90% dos pacientes. Estima-se que 30-90% dos pacientes com câncer em estágio terminal apresentem metástase em algum segmento da coluna vertebral. A alta prevalência das neoplasias malignas e a significativa experiência dos autores no tratamento das metástases na coluna vertebral motivaram uma atualização do tema. Acreditamos que a padronização da conduta e o conhecimento pormenorizado dos principais aspectos da doença, podem promover a melhor opção terapêutica. O presente estudo visa à revisão e descrição didática dos principais aspectos relacionados à fisiopatologia, diagnóstico e tratamento desta entidade.

  3. TEMA 14-2014: MANEJO DE LA ASCITIS MALIGNA NO REFRACTARIA

    OpenAIRE

    Medina Méndez, Andrea M.; Ávalos Chacón, David F.

    2014-01-01

    Las AM es una complicación que con frecuencia se encuentra en la fase terminal de varias neoplasias, sobre todo en las intraabdominales como el cáncer de ovario, colorectal, páncreas y útero. Sin embargo su manejo difiere de la ascitis por otra causa ya que su fisiopatología es muy diferente, aunque pueden coincidir en algunos aspectos como en el uso de diuréticos. Para lograr un mejor manejo de la AM, su líquido debe de ser estudiado y clasificado, ya que será ésta clasificación la que dará ...

  4. Rearreglos de genes de cadenas pesadas de las inmunoglobulinas en las gammapatías monoclonales Immunoglobulin heavy chain gene rearrangements in the monoclonal gammopathies

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    Andrea Bosaleh

    2005-06-01

    Full Text Available Las neoplasias de células plasmáticas resultan de la expansión de un clon de células B que secreta inmunoglobulinas, conocido como componente monoclonal o componente M. Las neoplasias malignas incluyen al mieloma múltiple y la macroglobulinemia de Waldenström, y la condición premaligna comprende las gammapatías monoclonales de significado incierto (MGUS. El MGUS presenta un componente monoclonal sin evidencia de mieloma múltiple, macroglobulinemia de Waldenström, amiloidosis primaria u otros desórdenes. El diagnóstico se basa en la combinación de características patológicas, radiológicas y clínicas. Aproximadamente el 25% de las gammapatías monoclonales de significado incierto desarrollarán mieloma múltiple, amiloidosis sistémica, macroglobulinemia o enfermedades linfoproliferativas malignas, indicando que sería una condición premielomatosa. El objetivo del presente trabajo es establecer la utilidad clínica de la inmunofenotipificación por citometría de flujo (CF y la detección de clonalidad por biología molecular. Se estudiaron 32 pacientes, siete con diagnóstico de mieloma múltiple y veinticinco con gammapatía monoclonal en estudio, los cuales fueron divididos en cuatro grupos basados en los datos clínicos y los resultados de CF. En el grupo de pacientes con CF no diagnóstica, se realizó la detección de los rearreglos de los genes de las cadenas pesadas de las inmunoglobulinas mediante reacción en cadena de la polimerasa (PCR, detectándose monoclonalidad en el 59% de los casos. El estudio de los rearreglos de los genes de las cadenas pesadas de las IgH mediante PCR incrementa la sensibilidad de detección de monoclonalidad.Plasma cell neoplasia occurs as a result of the expansion of an immunoglobulin-secreting B-cells clones, known as monoclonal component or M component. Malignant neoplasias include multiple myeloma and Waldenström macroglobulinemia, while premalignant conditions comprise monoclonal

  5. Efecto de la endotelina-1 sobre las arterias tumorales de pacientes con neoplasia colorrectal Effect of endothelin-1 on tumor arteries in patients with colorectal cancer

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    E. Ferrero Herrero

    2008-06-01

    Full Text Available La endotelina-1 es un péptido vasoconstrictor producido por el endotelio vascular, cuyos niveles plasmáticos están aumentados en los pacientes con cáncer colorrectal y que puede participar en la regulación del flujo sanguíneo tumoral. Para estudiar si la respuesta a este péptido está alterada en las arterias tumorales, se obtuvieron, de 13 pacientes intervenidos quirúrgicamente por cáncer colorrectal, arterias mesentéricas irrigando el tumor y arterias mesentéricas de una región alejada del tumor, y asimismo se obtuvieron arterias mesentéricas de pacientes intervenidos por diverticulitis (n = 4 o enfermedad inflamatoria intestinal (n = 3. Las arterias mesentéricas se montaron en una preparación para el registro de la contracción isométrica en un baño de órganos, encontrándose que la endotelina-1 producía contracción en los tres tipos de arterias, pero la sensibilidad a este péptido fue mayor en las arterias irrigando el tumor que en las arterias alejadas del tumor o en las arterias de pacientes sin patología tumoral. Estos resultados indican que la endotelina-1 puede regular el flujo sanguíneo en los tumores colorrectales, produciendo una mayor vasoconstricción en las arterias que irrigan el tumor que en las arterias no tumorales.Endothelin-1 is an endothelium-derived vasoconstrictor peptide whose plasma levels are increased in patients with colorectal cancer, and which may be involved in tumor blood flow regulation. To study whether response to this peptide is altered in tumor arteries, mesenteric arteries supplying blood flow to colorectal tumors, and mesenteric arteries far from said tumors were obtained from 13 patients undergoing colectomy; mesenteric arteries were also obtained from patients with diverticulitis (n = 4 or inflammatory bowel disease (n = 3. Arteries were prepared for isometric tension recording in an organ bath, and in this preparation it was found that endothelin-1 induced contraction in all three

  6. Estamos preparados para diagnosticar e conduzir um episódio de hipertermia maligna? Estamos preparados para diagnosticar y conducir un episodio de hipertermia maligna? Are we prepared to diagnose and managed malignant hyperthermia?

    Directory of Open Access Journals (Sweden)

    Claudia Marquez Simões

    2003-04-01

    reducida por el diagnóstico precoz y tratamiento específico, lo que incluye el dantrolene sódico. La población brasileña es de aproximadamente 160 millones de habitantes asistidos por más de 6000 anestesiologistas. En la última década, sobre todo, considerable atención fue dada a esta enfermedad, de esto, resultando especialistas mejor informados y más hospitales con instrumentos necesarios para tratarla. Este estudio visa evaluar el nivel actual de información acerca de la Hipertermia Maligna entre los anestesiologistas brasileños, de suerte a orientar nuevas iniciativas orientadas para el control de esta afección. MÉTODO: Veinte cuestiones sobre diagnóstico, prevención y tratamiento de la Hipertermia Maligna fueron enviadas a los 6164 miembros de la Sociedad Brasileña de Anestesiología (SBA. RESULTADOS: Seis cientos y cuarenta y seis anestesiologistas (10,4% respondieron a las cuestiones. Fueron obtenidas más de 90% de las respuestas correctas sobre diagnóstico y tratamiento. Por otro lado, aproximadamente 50% de las respuestas sobre indicación de la biopsia muscular y farmacología del dantrolene estaban erradas. CONCLUSIONES: Los resultados arriba reflejan nivel satisfactorio de información sobre este asunto, indicando algunos aspectos relevantes de la enfermedad que merecen atención adicional. El número de respuestas es significativo para evaluación del grado de conocimiento sobre este asunto, más denota insuficiente motivación. De estas notas se concluye que es necesario ampliar los esfuerzos de educación continuada, contemplando todo los diferentes tópicos de este importante tema de la Anestesiología.BACKGROUND AND OBJECTIVES: Malignant Hyperthermia (MH is an uncommon but potentially lethal disease associated to halogenate agents and/or succinylcholine exposure. Resulting mortality and morbidity may be decreased by early diagnosis and specific treatment, including sodium dantrolene. Brazil has approximately 160 million inhabitants

  7. Hipertermia maligna: aspectos moleculares e clínicos

    Directory of Open Access Journals (Sweden)

    Ana Carolina de Carvalho Correia

    2012-12-01

    Full Text Available CONTEÚDO: A hipertermia maligna (HM é uma doença farmacogenética potencialmente letal que acomete indivíduos geneticamente predispostos. Manifesta-se em indivíduos susceptíveis em resposta à exposição a anestésicos inalatórios, relaxantes musculares despolarizantes ou atividade física extrema em ambientes quentes. Durante a exposição a esses agentes desencadeadores, há um aumento rápido e sustentado da concentração de cálcio mioplasmático (Ca2+ induzido pela hiperativação dos receptores de rianodina (RYR1 do músculo esquelético, causando uma alteração profunda na homeostase de Ca2+, caracterizando um estado hipermetabólico. RYR1, canais de libertação de Ca2+ do retículo sarcoplasmático, é o principal local de susceptibilidade à HM. Várias mutações no gene que codifica a proteína RYR1 foram identificadas, mas outros genes podem estar envolvidos. Atualmente, o método padrão para o diagnóstico de sensibilidade à HM é o teste de contratura muscular para exposição ao halotano-cafeína (CHCT e o único tratamento é o uso de dantroleno. No entanto, com os avanços no campo da genética molecular, um pleno entendimento da etiologia da doença pode ser fornecido, favorecendo o desenvolvimento de um diagnóstico preciso, menos invasivo, com o teste de ADN, e também proporcionar o desenvolvimento de novas estratégias terapêuticas para o tratamento da HM. Logo, esta breve revisão tem como objetivo integrar os aspectos clínicos e moleculares da HM, reunindo informações para uma melhor compreensão desta canalopatia.

  8. Inmunohistoquimica y expresion de receptores de estrogenos y progesterona en neoplasias mamarias malignas caninas en distintos estadios clinicos

    National Research Council Canada - National Science Library

    Hermo, Guillermo; Soldati, Rocio; Wargon, Victoria; Scursoni, Alejandra; Lanari, Claudia; Gobello, Cristina

    2010-01-01

    La tecnica de inmunohistoquimica descrita por Walker y col. (1998) y Mote y col. (2001) es de utilidad para la determinacion de receptores de estrogenos y de progesterona en tumors mamarios de la hembra canina...

  9. Tendência da mortalidade por neoplasias malignas selecionadas em Rio Branco, Acre, Brasil, 1980-2006

    Directory of Open Access Journals (Sweden)

    Juliano de Pádua Nakashima

    2011-06-01

    Full Text Available A distribuição temporal da incidência e mortalidade por câncer na Amazônia Ocidental é desconhecida. As tendências das taxas de mortalidade por câncer ajustadas por idade nas localizações anatômicas apresentando maior magnitude entre 1980-2006 em Rio Branco, Acre, Brasil, foram modelizadas por meio de regressão linear. A tendência temporal da mortalidade por câncer em homens revelou padrão de crescimento não constante, e estabilidade em mulheres. Ao final da série, as taxas mais elevadas em mulheres foram, em ordem decrescente, colo uterino, pulmão, fígado e vias biliares intra-hepáticas, estômago e mama. No sexo masculino, foram pulmão, próstata, fígado e vias biliares intra-hepáticas, estômago e esôfago. O padrão observado revela elevação na mortalidade por câncer de mama e pulmão em mulheres, declínio de câncer de colo uterino, pulmão em homens, e estômago em ambos os sexos. A elevada mortalidade por câncer de fígado merece destaque em decorrência das elevadas taxas de infecção pelo vírus da hepatite B e C no Acre.

  10. Fasciíte nodular em quirodáctilo que simula neoplasia maligna de partes moles

    Directory of Open Access Journals (Sweden)

    Soraya Silveira Monteiro

    2014-01-01

    Full Text Available Fasciíte nodular (FN é uma lesão proliferativa fibroblástica rara, caracterizada clinicamente como uma massa solitária de consistência endurecida, pouco dolorosa à palpação, de crescimento rápido e sem predileção por sexo. O objetivo deste trabalho é relatar o caso de uma paciente com FN no terceiro quirodáctilo da mão esquerda, descrever os achados da radiografia simples, tomografia computadorizada e ressonância magnética e correlacionar com a literatura. Visto que o diagnóstico de FN é um desafio, é necessário conciliar os achados clínicos, radiológicos e patológicos.

  11. Eficacia de la quimioterapia sobre la eliminación de células tumorales ocultas en médula ósea en pacientes con cáncer de mama. Relación de las células tumorales en médula ósea con formas evolutivas de la enfermedad

    OpenAIRE

    García García, María Teresa

    2001-01-01

    El cáncer de mama es la neoplasia maligna más frecuentemente diagnosticada en la mujer (32% de los cánceres femeninos en EEUU y 34% en España), y es la primera causa de muerte por cáncer en la mujer en los países industrializados (en algunos países comienza a ser desplazada por el cáncer de pulmón), y la segunda en Latinoamérica, Africa y países del continente asiático. En España en 1994 supuso el 18.2% de todas las defunciones por cáncer en el sexo femenino, con una tasa de...

  12. Lentigo maligna - anatomic location as a potential risk factor for recurrences after non-surgical treatment

    NARCIS (Netherlands)

    K. Greveling (Karin); van der Klok, T. (Th.); M.B.A. van Doorn (Martijn); V. Noordhoek Hegt (Vincent); E.P. Prens (Errol)

    2016-01-01

    textabstractBackground: A higher incidence of lentigo maligna (LM) recurrences on the nose was previously observed in our cohort after non-surgical treatment. Objectives: To determine histological parameters that might be related to the previously observed higher incidence of LM recurrences on the n

  13. Anal squamous intraepithelial neoplasia.

    Science.gov (United States)

    Bejarano, Pablo A; Boutros, Marylise; Berho, Mariana

    2013-12-01

    Diagnosis, follow up, and treatment of anal intraepithelial neoplasia are complex and not standardized. This may be partly caused by poor communication of biopsy and cytology findings between pathologists and clinicians as a result of a disparate and confusing terminology used to classify these lesions. This article focuses on general aspects of epidemiology and on clarifying the current terminology of intraepithelial squamous neoplasia, its relationship with human papilloma virus infection, and the current methods that exist to diagnose and treat this condition. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Detection of colorectal neoplasia

    DEFF Research Database (Denmark)

    Wilhelmsen, Michael; Christensen, Ib J; Rasmussen, Louise

    2017-01-01

    Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed 8 cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA, hs...

  15. Susceptibilidade à hipertermia maligna em três pacientes com síndrome maligna por neurolépticos Malignant hyperthermia susceptibility in three patients with malignant neuroleptic syndrome

    National Research Council Canada - National Science Library

    HELGA C. A. SILVA; VALÉRIA S. BAHIA; ROGÉRIO A. A. OLIVEIRA; PAULO E. MARCHIORI; MILBERTO SCAFF; ANA MARIA C. TSANACLIS

    2000-01-01

    .... A síndrome maligna por neurolépticos caracteriza-se por hipertermia, síndrome extrapiramidal, acidose, instabilidade neurovegetativa e alterações neurológicas. Descrevemos três pacientes com...

  16. Mortalidade por neoplasias no Brasil (1980/1983/1985: agrupamento dos Estados, comportamento e tendências Mortality from neoplasms in Brazil (1980/1983/1985: grouping by State, behaviors and tendencies

    Directory of Open Access Journals (Sweden)

    Fábio Gonçalves Pinto

    1991-08-01

    Full Text Available Examinou-se a mortalidade por neoplasias no Brasil, utilizando-se dados oficiais do Ministério da Saúde, abrangendo 26 Unidades da Federação e 13 diferentes localizações neoplásicas, para os anos de 1980, 1983 e 1985. As Análises de Agrupamento e de Componentes Principais revelaram comportamento heterogêneo entre regiões do país, com relação às 13 variáveis estudadas, sendo que os principais elementos discriminantes foram as neoplasias malignas da traquéia/brônquio/pulmão, seguidas das do estômago, esôfago, cólon e pâncreas. Análises complementares evidenciaram tendência de crescimento das taxas de mortalidade para as neoplasias malignas da próstata (17,74%, da traquéia/brônquio/pulmão(15,22%, da mama (11,32%, do pâncreas (10,23%, do cólon (8,08%, do colo uterino (6,45% e da laringe (6,36%. Houve redução da mortalidade por neoplasias benignas/carcinoma "in situ"/ outras (27,37%, por neoplasias malignas no reto sigmóide/ânus (7,67%, do estômago (5,31%, de outro local do útero não especificado (2,56%, por leucemia (0,70% e por neoplasias malignas do esôfago (0,44%. As neoplasias malignas do estômago foram a principal causa de morte por câncer no Brasil, representando 21,30% do total médio, seguidas das neoplasias malignas da traquéia/brônquio/pulmão(17,49% do total médio. Destacam-se os altos índices de mortalidade por neoplasias malignas do esôfago no Estado do Rio Grande do Sul.Mortality caused by neoplasms in Brazil was examined by means of official Ministry of Health data covering 26 of the Federal Units and 13 different tumoral sites and referring to the years 1980,1983 and 1985. Both cluster analyses and those of principal components have shown heterogenous behaviour as between the different regions of the country in relation to the 13 variants studied. The main discriminatory elements are the trachea/bronchus/lung malign neoplasms followed by those of stomach, pancreas, colon and larynx

  17. Immune thrombocytopenic purpura: A rare side effect in a patient treated with Imiquimod for lentigo maligna

    Directory of Open Access Journals (Sweden)

    E.A. Whatling

    2017-09-01

    Full Text Available Topical Imiquimod is increasingly used in the treatment of lentigo maligna (LM for patients not suitable or willing for surgery. It acts as an immune response modifier and is recommended for use with caution in patients with autoimmune disorders. A review of the literature did not reveal any reported cases of Idiopathic Thrombocytopenic Purpura (ITP with the use of Imiquimod so far. We report a case of a 55-year-old woman with a history of Addison's and Graves' disease who had been diagnosed with lentigo maligna on the right nasal ala. Within two days of commencing of topical Imiquimod treatment, she was admitted to the hospital with extensive cutaneous and mucosal bruising and treated as acute Idiopathic Throbocytopenic Purpura. Deranged platelets were reversed promptly with treatment and Imiquimod discontinued. We demonstrate that Idiopathic Throbocytopenic Purpura is a potential life-threatening side effect of Imiquimod treatment and patients who have autoimmune disorders are at increased risk of developing this side effect. We recommend that Imiquimod is contraindicated in patients with autoimmune disease. Here we describe the clinical presentation and review the relevant literature on Imiquimod treatment for lentigo maligna and its potential side effects.

  18. Conhecimento e prática de enfermeiros no cuidado a pacientes com feridas tumorais malignas

    Directory of Open Access Journals (Sweden)

    Glenda Agra

    2017-09-01

    Full Text Available Introdução: As feridas tumorais malignas representam uma angústia para pacientes que enfrentam uma doença terminal, uma vez que são lesões desfigurantes, sem possibilidades de cicatrização e que desenvolvem sintomas de difícil controle. O objetivo foi verificar o conhecimento e prática de enfermeiros no cuidado a pacientes com feridas tumorais malignas. Materiais e Métodos: Trata-se de um estudo exploratório, descritivo, quantitativo realizado com 22 enfermeiros de um hospital da Paraíba, Brasil, durante o período de abril a junho de 2016. O instrumento foi um questionário estruturado baseado no protocolo do Ministério da Saúde. Para a análise dos dados utilizou-se estatística descritiva e literatura pertinente. Resultados: Os resultados permitiram identificar que os enfermeiros apresentam lacunas no conhecimento de conteúdos e técnicas sobre avaliação e tratamento de pacientes com feridas neoplásicas. Além disso, constatou-se que os enfermeiros não executam alguns cuidados pertinentes a essa clientela. Discussão: Acredita-se que essas fragilidades estejam relacionadas ao dimensionamento de pessoal, déficit no conhecimento, inabilidade em realizar cuidados com feridas tumorais malignas, falta de insumos que auxiliem na avaliação e tratamento da lesão, inexistência de protocolo institucional para o cuidado com essas lesões. Conclusões: Desse modo, a instituição lócus da pesquisa precisa investir em educação permanente, a fim de treinar a equipe de enfermagem para o acompanhamento de pacientes com feridas tumorais malignas, adquirir materiais necessários e implantar protocolos assistenciais que norteiem a prática de métodos avaliativos e terapêuticos para o cuidado com pessoas com essas lesões, familiares e cuidadores. Como citar este artigo: Agra G, Medeiros MVS, Brito DTF, Sousa ATO, Formiga NS, Costa MML. Conhecimento e prática de enfermeiros no cuidado a pacientes com feridas tumorais malignas. Rev

  19. Susceptibilidade à hipertermia maligna em três pacientes com síndrome maligna por neurolépticos Malignant hyperthermia susceptibility in three patients with malignant neuroleptic syndrome

    Directory of Open Access Journals (Sweden)

    HELGA C. A. SILVA

    2000-09-01

    Full Text Available A hipertermia maligna caracteriza-se por hipertermia, rigidez muscular, rabdomiólise, acidose e insuficiência de múltiplos órgãos. A hipertermia maligna anestésica decorre da exposição a halogenados e/ou relaxantes musculares despolarizantes. O método padrão para diagnosticar a suscetibilidade à hipertermia maligna é o teste da contratura muscular in vitro em resposta ao halotano e à cafeína. A síndrome maligna por neurolépticos caracteriza-se por hipertermia, síndrome extrapiramidal, acidose, instabilidade neurovegetativa e alterações neurológicas. Descrevemos três pacientes com síndrome maligna por neurolépticos e testes de contratura muscular positivos. Esse achado demonstra que ocasionalmente o músculo de pacientes com síndrome maligna por neurolépticos pode mostrar as alterações encontradas na hipertermia maligna anestésica.Hyperthermia, skeletal muscle rigidity, rhabdomyolysis, acidosis and multiple system insufficiency characterize malignant hyperthermia. Anaesthetic malignant hyperthermia follows halogenated volatile agents and/or depolarizing muscle relaxants utilization. Diagnosis is based on in vitro muscle contracture in response to halothane and/or caffeine exposure. Neuroleptic malignant syndrome affects patients taking neuroleptic drugs; clinical findings include hyperthermia, extrapyramidal rigidity, acidosis, neurovegetative instability and neurological signs. We report three neuroleptic malignant syndrome patients with positive muscle contracture tests which shows that muscle from neuroleptic malignant syndrome patients may in some instances show alterations similar to those of anaesthetic malignant hyperthermia.

  20. Papilomavírus humano e neoplasia cervical Human papillomavirus and cervical neoplasia

    Directory of Open Access Journals (Sweden)

    Maria Inês da Rosa

    2009-05-01

    Full Text Available O papilomavírus humano (HPV é um fator etiológico bem estabelecido para o câncer cervical. Esse vírus de DNA infecta primariamente o epitélio e pode induzir lesões benignas ou malignas na pele e na mucosa. Alguns HPVs são considerados de alto risco, responsáveis pela progressão das lesões precursoras até câncer cervical. A infecção genital pelo HPV é comum em mulheres jovens e geralmente é transitória. Uma pequena proporção de mulheres infectadas desenvolve câncer cervical, implicando o envolvimento de fatores ambientais e fatores genéticos na carcinogênese. Essa revisão aborda a estrutura viral, classificação e patologia do HPV, história natural e fatores de risco para neoplasia cervical e perspectivas futuras com a vacina anti-HPV.Human papillomavirus (HPV has been established as an important etiological factor for the development of cervical cancer. This DNA virus primarily infects the epithelium and can induce benign and malignant lesions of the mucous membranes and skin. Some HPVs are considered high risk due to their role in malignant progression of cervical tumors. Genital HPV infections are common and usually transient among young sexually active women. Only a small fraction of infected women develop cervical cancer, implying the involvement of environmental and genetic cofactors in cervical carcinogenesis. Classification, virology, pathology, natural history, epidemiological features of genital HPV infection, and future prospects for cervical cancer prevention with HPV vaccines will be reviewed here.

  1. Neoplasia vaginal intraepitelial

    OpenAIRE

    Baquedano M.,Laura; Lamarca B,Marta; José G,Yasmina; Rubio C,Patricia; Ruiz C,Miguel Ángel

    2013-01-01

    Objetivo: Actualizar los conocimientos disponibles sobre la neoplasia vaginal intraepitelial (VAIN) especialmente en el diagnóstico y tratamiento. Métodos: Revisión de la literatura en Pubmed de los últimos 20 años, especialmente de los publicados desde 2005 hasta la actualidad y considerando sobre todo los ensayos clínicos aleatorizados. Resultados: Su prevalencia real es desconocida, aunque es una patología rara generalmente en mujeres posmenopaúsicas. Su fisiopatología es similar a la neop...

  2. Resultados preliminares de la pleurodesis con talco para el tratamiento de los derrames pleurales de causa maligna Preliminary results of talc pleurodesis for the treatment of pleural effusions of malignant origin

    OpenAIRE

    Juan Carlos Collado Otero; José Manuel Vázquez González; Ricardo Almeida Varela; José Luís Guerra Mesa; Yoel Rodríguez Borges

    2007-01-01

    Se realizó un corte preliminar de un estudio descriptivo y prospectivo que se lleva a cabo en el Instituto Nacional de Oncología y Radiobiología, con el objetivo de conocer la efectividad de la pleurodesis con talco para evitar las recidivas de los derrames pleurales de causa maligna, aplicado a través de una pleurotomía mínima baja o por videotoracoscopia. Además, para valorar la ocurrencia de efectos adversos y complicaciones. Catorce individuos fueron incluidos tras presentar derrames secu...

  3. Neoplasias duodenais primárias: análise de casuística e conduta cirúrgica

    Directory of Open Access Journals (Sweden)

    Sansom Henrique Bromberg

    Full Text Available São apresentados 18 casos de neoplasias primárias do duodeno, salientando-se sua raridade e as dificuldades diagnósticas, a despeito dos modernos recursos endoscópicos e de identificação por imagem. A literatura revela que de 1% a 10% de todos os tumores do aparelho digestório se situam no intestino delgado. A localização duodenal é, por isso, muito pouco freqüente, possui sintomatologia indefinida e implica conduta terapêutica mais complexa do que quando o tumor se situa em outros segmentos do intestino delgado. Os sintomas mais comuns são dor, náusea, vômito e hemorragia. A presente casuística consiste de 11 neoplasias malignas e sete benignas. Entre as primeiras o adenocarcinoma é o mais freqüente, sendo os lipomas os mais comuns dos neoplasmas benignos. Enquanto nestes a exérese local representa a conduta mais adequada, a duodenopancreatectomia cefálica foi a cirurgia de escolha nos tumores malignos da segunda porção duodenal, exibindo bons resultados. As lesões malignas da terceira porção e principalmente da quarta porção do duodeno foram tratadas pela ressecção duodenojejunal, também com resultados satisfatórios.

  4. Estamos preparados para diagnosticar y conducir un episodio de hipertermia maligna?

    OpenAIRE

    Claudia Marquez Simões; Giovanna Negrisoli Koishi; Marcelo Rozatti; José Luiz Gomes do Amaral

    2003-01-01

    JUSTIFICATIVA E OBJETIVOS: A Hipertermia Maligna é doença rara e potencialmente fatal associada à exposição a agentes halogenados e succinilcolina. A mortalidade e morbidade resultante pode ser reduzida pelo diagnóstico precoce e tratamento específico, o que inclui o dantrolene sódico. A população brasileira é de aproximadamente 160 milhões de habitantes assistidos por mais de 6000 anestesiologistas. Na última década, sobretudo, considerável atenção foi dada à esta doença, disto resultando es...

  5. Hipertermia maligna no Brasil: análise da atividade do hotline em 2009 Hipertermia maligna en Brasil: análisis de la actividad del hotline en 2009 Malignant hyperthermia in Brazil: analysis of hotline activity in 2009

    Directory of Open Access Journals (Sweden)

    Helga Cristina Almeida da Silva

    2013-02-01

    foram similares às descritas em outros países. É preciso aumentar o conhecimento sobre HM no Brasil.JUSTIFICATIVA Y OBJETIVOS: La Hipertermia Maligna (HM es una enfermedad farmacogenética, con una reacción hipermetabólica anormal a los anestésicos halogenados y/o relajantes musculares despolarizantes. Desde 1991 existe un servicio hotline de atención telefónica para la HM en Brasil a disposición las 24 horas del día en São Paulo. Este artículo analiza la actividad del servicio brasileño de hotline para la HM en el 2009. MÉTODOS: Análisis prospectivo de todas las llamadas telefónicas realizadas al servicio brasileño de hotline para la HM, desde enero a diciembre de 2009. RESULTADOS: Se recibieron 22 llamadas; 21 provenientes del Sur y Sudeste de Brasil y una del Norte. Quince eran solicitudes de informaciones generales sobre la HM. Siete fueron sobre sospechas de crisis agudas de HM, de las cuales dos no fueron consideradas como HM. En las cinco crisis compatibles con la HM, todos los pacientes recibieron anestésicos inhalatorios halogenados (2 isoflurano, 3 sevoflurano y uno también usó succinilcolina. Había cuatro hombres y una mujer, con un promedio de edad de 18 años (2-27. Los problemas descritos en las cinco crisis de HM: taquicardia (cinco, aumento del gas carbónico espirado (cuatro, hipertermia (tres, acidemia (uno, rabdomiólisis (uno y mioglobinuria (uno. Un paciente recibió dantrolene. Todos los cinco pacientes con crisis de HM recibieron acompañamiento en la unidad de cuidados intensivos y se recuperaron sin secuelas. La susceptibilidad a la HM fue posteriormente confirmada en dos pacientes por medio del test de la contractura muscular in vitro. CONCLUSIONES: El número de llamadas por año al servicio brasileño de hotline para la HM todavía es pequeño. Las características de las crisis fueron similares a las descritas en otros países. Es necesario aumentar el conocimiento que se tiene sobre la HM en Brasil.BACKGROUND AND

  6. [Multiple endocrine neoplasia].

    Science.gov (United States)

    Schaaf, Ludwig; Raue, Friedhelm

    2017-09-01

    Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. The clinical expression of the different tumors can vary within and between families, with a good genotype-phenotype correlation in MEN2. Early diagnosis and therapy is possible by using biochemical and imaging screening in the families. Early thyroidectomy in young patients with MEN2 results in a high cure rate of MTC. © Georg Thieme Verlag KG Stuttgart · New York.

  7. Multiple Endocrine Neoplasia Type I

    Science.gov (United States)

    ... treatment as needed. References [1] White ML, Doherty GM. Multiple endocrine neoplasia. Surgical Oncology Clinics of North ... for questions about any medications, contact the U.S. Food and Drug Administration toll-free at 1-888- ...

  8. Caracterización del mieloma múltiple y de su componente monoclonal durante 14 años en Las Tunas

    Directory of Open Access Journals (Sweden)

    Olga Lina Pupo Rodríguez

    2015-11-01

    Full Text Available El mieloma múltiple es una neoplasia de células plasmáticas que representa el 10% de las enfermedades hematológicas malignas. La mayoría de los pacientes presentan síntomas, signos y trastornos de laboratorio sugestivos de enfermedad activa, incluyendo lesiones osteolíticas activas, hipercalcemia, anemia y fallo renal. Para el diagnóstico de esta enfermedad hay que tener en cuenta las manifestaciones clínicas, los estudios radiológicos, pruebas especiales como citología celular y exámenes de laboratorio como la electroforesis de proteína en suero y orina, inmunoelectroforesis, cuantificación de inmunoglobulinas y proteína de Bence-Jones. Se realizó un estudio con el objetivo de evaluar las características de las variables inmunológicas mediante la determinación de inmunoglobulinas (inmunodifusión radial simple o inmunoturbidimetría en un analizador automático HITACHI, proteínas totales (método de Biuret o en el analizador HITACHI y electroforesis de proteínas en suero y orina en pacientes remitidos de la consulta de Hematología del Hospital “Ernesto Guevara de la Serna” de Las Tunas, con el diagnóstico de mieloma múltiple. La clase IgG fue la predominante en los 127 casos estudiados (73,3%, seguido de la IgA (16,5% y de cadenas ligeras (9,5%. Se han registrado dos casos de macroglobulinemia de Waldeström. En correspondencia con lo reportado en la literatura, en la provincia de Las Tunas el isotipo más frecuente en pacientes afectados por mieloma múltiple es de clase IgG.

  9. NEOPLASIAS TESTICULARES EN CANINOS: UN CASO DE TUMOR DE CÉLULAS DE SERTOLI

    OpenAIRE

    Pedro Eslava M; Giovanny Torres V

    2008-01-01

    Las neoplasias del testículo no son muy frecuentes en los animales domésticos Los caninos son los que las manifiestan con mayor frecuencia; estando entre los 0.7 y 4.6% de todos los tumores que sufren. Algunos factores se han asociado como predisponentes: entre ellos la edad madura y la presencia del criptorquidia uni o principalmente bilateral. Las neoplasias del testículo más frecuente son el tumor de células de Sertoli, el tumor de células de Leydig y los seminomas, que en general presen...

  10. Intrathoracic neoplasia: Epidemiology and etiology

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1992-05-01

    Neoplasms of the thorax encompass those derived from the thoracic wall, trachea, mediastinum, lungs and pleura. They represent a wide variety of lesions including benign and malignant tumors arising from many tissues. The large surface area, 60 to 90 m{sup 2} in man, represented by the respiratory epithelium and associated thoracic structures are ideal targets for carcinogens carried by inspired air. The topic of discussion in this report is the epidemiology, etiology, and mechanisms of spontaneous intrathoracic neoplasia in animals and man. Much of what we know or suspect about thoracic neoplasia in animals has been extrapolated from experimentally-induced neoplasms.

  11. Síndrome de Sweet asociado a neoplasias Sweet's syndrome associated with neoplasms

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    Mariana Franco

    2006-10-01

    Full Text Available El síndrome de Sweet fue descrito en el año 1964 por Robert Douglas Sweet, como una entidad a la cual denominó dermatosis neutrofílica febril y aguda. Se caracteriza por cinco rasgos principales: 1 aparición brusca de placas eritemato-dolorosas en cara, cuello y extremidades; 2 fiebre; 3 leucocitosis polimorfonuclear; 4 denso infiltrado dérmico a predominio neutrofilico; 5 rápida respuesta al tratamiento esteroideo. Se puede clasificar en cinco grupos: idiopático, parainflamatorio, paraneoplásico, secundario a drogas y asociado a embarazo. En el 20% de los casos se asocia a enfermedades malignas, representando las hematológicas el 85% y los tumores sólidos el 15% restante. Se presenta una serie de siete casos de síndrome de Sweet asociado a neoplasias, diagnosticados durante el período 2002-2006, de los cuales seis correspondieron a enfermedades oncohematológicas y el restante a tumores sólidos. Como comentario de dicha casuística, se hace hincapié en la importancia del diagnóstico de este síndrome, debido a que puede anunciar la recaída del tumor o la progresión de la enfermedad de base. De esta manera, mediante el uso de métodos de diagnóstico y tratamiento oportunos, se lograría mejorar la calida de vida de estos pacientes. También debe tenerse en cuenta, que los pacientes oncológicos reciben múltiples medicaciones (factor estimulante de colonias, que pueden estar implicadas en la aparición de esta entidad, debiendo ser las mismas descartadas como posibles causas.Sweet's syndrome was described in 1964 by Robert Douglas Sweet, as an entity he named acute febrile neutrophilic dermatosis. It is characterized by five main features: 1 sudden appearance of erythematous and tender plaques on the face, neck and extremities; 2 fever; 3 polymorphonuclear leukocytes; 4 predominantly neutrophilic dense infiltrate in the dermis, and 5 rapid response to steroid therapy. Sweet's syndrome can be classified into five groups

  12. Identificación de lesiones mamarias malignas en México Identification of malignant breast lesions in Mexico

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    Lizbeth López-Carrillo

    2001-06-01

    Full Text Available Objetivo. Evaluar la forma en que se detectan las lesiones mamarias malignas en la ciudad de México y estimar el número de pacientes que son diagnosticadas en etapas avanzadas de dicho tumor. Material y métodos. Estudio transversal realizado en 256 mujeres entre 1994 y 1996, a quienes se les hizo un diagnóstico histopatológico de cáncer mamario en tres hospitales públicos de tercer nivel en la ciudad de México. Se les entrevistó personalmente y se obtuvo información acerca de sus características reproductivas, clínicas y la forma en la que fue detectado el cáncer mamario. Se calcularon porcentajes y razones de momios, con un intervalo de confianza de 95%. Resultados. El 90% de las mujeres identificaron por sí mismas la presencia de un abultamiento en el seno. Del total de las pacientes, sólo 10% fueron diagnosticadas con tumores en estadio I y 27 casos fueron identificados por el médico; estos últimos resultaron con tumores de estadios II B en adelante. Conclusiones. La situación actual sugiere que la mortalidad por cáncer mamario en la ciudad de México mantendrá su tendencia al incremento, a menos de que se logre aumentar la proporción de mujeres diagnosticadas en la etapa de los tumores in situ, para lo cual se requieren cambios en el funcionamiento de los servicios y un vasto esfuerzo educativo entre la población susceptible de desarrollar la enfermedad. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.htmlObjective. To evaluate the modes of detection of breast malignancies in Mexico City and to estimate the number of patients diagnosed in advanced stages. Material and methods. This cross-sectional study was conducted between 1994 and 1996, among 256 women with a histological diagnosis of breast cancer, at three tertiary level public hospitals in Mexico City. Personal interviews were conducted to collect data on reproductive characteristics, clinical history, and breast

  13. Hipertermia maligna no Brasil: análise da atividade do hotline em 2009

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    Helga Cristina Almeida da Silva

    2013-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Hipertermia maligna (HM é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este artigo analisa a atividade do serviço brasileiro de hotline para HM em 2009. MÉTODOS: Análise prospectiva de todas chamadas telefônicas paria maligna (HM é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este art go analisa a at vidade do serviço brasileiro de hotline para HM em 2009a o serviço brasileiro de hotline para HM, de janeiro a dezembro de 2009. RESULTADOS: Foram recebidas 22 ligações; 21 provenientes do Sul-Sudeste do Brasil e uma do Norte. Quinze eram pedidos de informações gerais sobre HM. Sete foram suspeitas de crises agudas de HM, das quais duas não foram consideradas como HM. Nas cinco crises compatíveis com HM, todos os pacientes receberam anestésicos inalatórios halogenados (2 isoflurano, 3 sevoflurano e um usou também succinilcolina; havia quatro homens e uma mulher, com média de idade de 18 anos (2-27. Problemas descritos nas cinco crises de HM: taquicardia (cinco, aumento do gás carbônico expirado (quatro, hipertermia (três, acidemia (um, rabdomiólise (um e mioglobinúria (um. Um paciente recebeu dantrolene. Todos os cinco pacientes com crises de HM foram seguidos em unidade de terapia intensiva e recuperaram-se sem sequelas. A suscetibilidade à HM foi posteriormente confirmada em dois pacientes por meio do teste de contratura muscular in vitro. CONCLUSÕES: O número de chamadas por ano no serviço brasileiro de hotline para HM ainda é reduzido. As características das crises

  14. Presença do papilomavirus humano em lesões malignas de mucosa oral

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    Soares Christiane Pienna

    2002-01-01

    Full Text Available O objetivo deste estudo foi investigar a prevalência do papilomavírus humano 6/11 e 16/18 em pacientes, com lesões orais clínicamente diagnosticadas como leucoplasias, atendidas na Faculdade de Odontologia de Araraquara, UNESP, Brasil. Após a inclusão em parafina, os cortes corados com H&E, foram selecionadas 30 biópsias e separadas em 3 grupos: lesões sem displasia (n=10, lesões com diferentes graus de displasia (n=10 e carcinoma espinocelular invasivo(n=10. As lesões que apresentaram displasia epitelial foram classificadas de acordo com os critérios histopatológicos propostos por Van Der Waal. As lesões foram investigadas para a presença de HPV por hibridização in situ com sondas biotiniladas de amplo espectro, 6/11 e 16/18. HPV 16/18 foi detectado em 20% (n=2 das biópsias com displasia severa. A presença de HPV 16/18 em lesões malignas sugere sua importância como fator de risco na carcinogênese oral.

  15. The perimeter technique for lentigo maligna: an alternative to Mohs micrographic surgery.

    Science.gov (United States)

    Mahoney, Mary-Helen; Joseph, Mariamma; Temple, Claire L F

    2005-08-01

    Lentigo maligna (LM) presents a challenge for complete surgical excision because of its extensive subclinical spread and predilection for the face. To report our experience using the staged perimeter technique as an alternative to Mohs micrographic surgery for treatment of LM. The perimeter procedure was performed on 11 patients with LM between March 2003 and June 2004. Data on patient and lesion characteristics, number of stages required to obtain clear margins, and follow-up was obtained by chart review. A mean of 1.9 stages were required to achieve clear margins. A mean of 7 tissue specimens were sent to pathology per patient for evaluation. After a mean follow-up of 4.7 months, all patients were free of recurrence. The perimeter technique is a simple method of margin-controlled excision of LM. The main advantage is that all margins are examined with permanent sections. The main drawback is that multiple operative sessions are required to complete the procedure. This technique does not require specific Mohs training and is therefore applicable to non-Mohs surgeons. Copyright 2005 Wiley-Liss, Inc.

  16. Teratoma de mediastino com degeneração maligna Mediastinal teratoma with malignant degeneration

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    Fabiano Alves Squeff

    2008-08-01

    Full Text Available No presente artigo, relatamos o caso de um paciente portador de teratoma de mediastino anterior, de evolução lenta, o qual foi submetido à ressecção cirúrgica. O exame anatomopatológico da peça revelou degeneração maligna para tumor carcinóide. Tal evolução é extremamente rara, sendo encontrados na literatura apenas três artigos correlatos. Apresentamos uma descrição clínico-patológica do tumor e, por fim, discutimos a conduta terapêutica. Houve evolução satisfatória, e o paciente foi submetido a tratamento oncológico.Here, we report the case of a patient with a slowly-progressing anterior mediastinal teratoma submitted to surgical resection. The anatomopathological examination of the sample revealed malignant degeneration to carcinoid tumor. Such evolution is very rare, and we have found only three related studies in the literature. We describe the clinicopathological features of the tumor and discuss the treatment administered. The evolution was satisfactory, and the patient was submitted to oncological treatment.

  17. Transplante cardíaco e neoplasias: experiência na Escola Paulista de Medicina da Universidade Federal de São Paulo

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    Mello Junior Walter Teixeira de

    2006-01-01

    Full Text Available OBJETIVOS: Analisar ocorrência e tipos de neoplasias que se desenvolveram em pacientes submetidos a transplante cardíaco ortotópico, no Programa de Transplante Cardíaco da Escola de Paulista de Medicina da Universidade Federal de São Paulo. MÉTODOS: O presente estudo apresenta uma análise observacional de 106 pacientes submetidos a transplante cardíaco ortotópico, no período de novembro de 1986 a setembro de 2002, que sobreviveram por período superior a trinta dias após o procedimento. O regime de imunossupressão consistiu de terapia tríplice com ciclosporina A, azatioprina e corticosteróide. Apenas dois pacientes receberam, além da terapia tríplice, a adição de ortoclone OKT-3. O período médio de acompanhamento foi de 61,4 meses. (variação de dois meses a 192 meses. RESULTADOS: Vinte e três pacientes (21,3% desenvolveram neoplasias, dos quais 56,5% apresentaram neoplasia de pele, 30,1% apresentaram tumores sólidos e 13,4%, doença linfoproliferativa pós-transplante (DLPT. O intervalo médio entre o transplante e o diagnóstico de neoplasia foi: pele - 54,9 meses, tumores sólidos - 24,8 meses e DLPT - 70,3 meses. CONCLUSÕES: A ocorrência de neoplasias malignas foi relativamente comum na população analisada. O câncer de pele prevaleceu em relação às demais neoplasias e os tumores sólidos foram mais diagnosticados do que as doenças linfoproliferativas nessa série de pacientes.

  18. Diabetes Mellitus and Colorectal Neoplasia

    Science.gov (United States)

    Acevedo, Alejandro; Diaz, Yaritza; Perez, Cynthia M.; Garau, Maria; Baron, John

    2012-01-01

    Background Many studies have provided evidence for an association between obesity, physical inactivity, and western diet as risk factors for colorectal cancer (CRC). Few studies directly address the association between type 2 Diabetes Mellitus (DM) and the risk of colorectal lesions at specific anatomic locations. Methods 2,663 subjects with a previous history of adenoma(s) and removal of all current adenomas at study entry were followed for a mean time of three years across three different chemoprevention clinical trials. The primary endpoint was colorectal adenoma recurrence and number of lesions during the treatment phase; the secondary endpoints were presence of advanced colorectal neoplasia (CRN) and location of CRN. Using log linear regression, the effect of DM status on the relative risk (RR) of CRN recurrence, advanced CRN, and location of CRN was assessed. Results DM status was not significantly associated with incidence of colorectal adenomas, incidence of advanced colorectal lesions, or left-sided colorectal neoplastic lesions. Subjects with DM had a marginally increased risk of right-sided (p= 0.06) colorectal adenomas and a significant increased risk of multiple right-sided adenomas (p=0.03) in the unadjusted model; this association was not significant after adjusting for age and other potential confounders (RR=1.22, 95% CI: 0.85–1.76). Conclusion We did not observe a statistically significant increased risk in CRN recurrence for overall neoplasia, advanced neoplasia or location of neoplasia in individuals with DM compared to non-DM individuals. However, given the patterns observed in this investigation, future studies with longer follow-up time and longer DM exposure, incorporating objective measurements of type 2 DM might help elucidate the risk of CRN among individuals with DM. PMID:23560242

  19. Surgery for cervical intraepithelial neoplasia

    Science.gov (United States)

    Martin-Hirsch, Pierre PL; Paraskevaidis, Evangelos; Bryant, Andrew; Dickinson, Heather O; Keep, Sarah L

    2014-01-01

    Background Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. Atypical squamous changes occur in the transformation zone of the cervix with mild, moderate or severe changes described by their depth (CIN 1, 2 or 3). Cervical intraepithelial neoplasia is treated by local ablation or lower morbidity excision techniques. Choice of treatment depends on the grade and extent of the disease. Objectives To assess the effectiveness and safety of alternative surgical treatments for CIN. Search methods We searched the Cochrane Gynaecological Cancer Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE and EMBASE (up to April 2009). We also searched registers of clinical trials, abstracts of scientific meetings and reference lists of included studies. Selection criteria Randomised controlled trials (RCTs) of alternative surgical treatments in women with cervical intraepithelial neoplasia. Data collection and analysis Two review authors independently abstracted data and assessed risks of bias. Risk ratios that compared residual disease after the follow-up examination and adverse events in women who received one of either laser ablation, laser conisation, large loop excision of the transformation zone (LLETZ), knife conisation or cryotherapy were pooled in random-effects model meta-analyses. Main results Twenty-nine trials were included. Seven surgical techniques were tested in various comparisons. No significant differences in treatment failures were demonstrated in terms of persistent disease after treatment. Large loop excision of the transformation zone appeared to provide the most reliable specimens for histology with the least morbidity. Morbidity was lower than with laser conisation, although the trials did not provide data for every outcome measure. There were not enough data to assess the effect on morbidity when compared with laser ablation. Authors’ conclusions The evidence

  20. Primary plasmacytoma of the thyroid gland: a case report of a rare neoplasia Plasmocitoma da glândula tireoide: relato de caso de uma rara neoplasia

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    Eduardo Cambruzzi

    2012-08-01

    Full Text Available Extramedullary plasmacytoma comprises 3%-5% of all plasma cell neoplasms, and approximately 80% of the cases occur in the upper respiratory tract. Primary thyroid plasmacytomas (PTP are rare tumors. The authors report a case of PTP in a male patient with dyspnea and dysphagia. Physical examination and computerized tomography (CT scan revealed a solid tumor affecting the thyroid gland, measuring 12 cm in its greatest dimension. Surgical biopsy was performed. Microscopy revealed a hypercellular malignant neoplasm composed of round plasmacytoid cells arranged in solid nests, which showed a positive immunoexpression for CD138, epithelial membrane antigen (AME, kappa light chains and multiple myeloma oncogene 1 (MUM1. The diagnosis of PTP was accordingly established.O plasmocitoma extramedular constitui 3%-5% de todas as neoplasias de plasmócitos e aproximadamente 80% dos casos ocorrem no trato respiratório superior. Plasmocitomas primários da tireoide (TPP são tumores raros. Os autores relatam um caso de TPP em um paciente masculino referindo dispneia e disfagia. O exame físico e a tomografia computadorizada revelaram tumor sólido comprometendo a glândula tireoide, medindo 12 cm na maior dimensão, o qual foi submetido à biópsia cirúrgica. À microscopia, foi identificada neoplasia maligna hipercelular constituída por células redondas/plasmocitoides dispostas em ninhos sólidos, as quais exibiam imunoexpressão positiva para CD138, antígeno da membrana epitelial (AME, cadeias leves kappa e oncogene mieloma múltiplo 1 (MUM1. O diagnóstico de TPP foi, então, estabelecido.

  1. Resonancia Magnética de las glándulas salivales parótida y submaxilar

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    María Cristina Hernández Rodríguez

    2016-11-01

    Full Text Available Las glándulas salivares se dividen en glándulas salivares mayores y menores, incluyendo islotes de tejido distribuídos por la vía aérea superior. Existen numerosas entidades que pueden afectar a estas estructuras condicionando diversos tipos de patología. Dada la mayor relevancia de la glándula submaxilar y parótida, este artículo se centra en su estudio.Para ello se realizó una revisión retrospectiva de pacientes con estudios de  resonancia magnética con sospecha o confirmación de patología de glándulas salivares, a lo largo de cinco años (2011-2015,  suponiendo un total de 123 pacientes.La resonancia magnética (RM permitió identificar en la mayoría de los pacientes objeto de estudio diversas patologías, incluyendo trastornos inflamatorio-infecciosos, neoplasias benignas y malignas e incluso patología autoinmune.Los estudios de RM permiten una adecuada valoración de la anatomía glandular, adenopatías y  litiasis. No obstante, la resonancia es la técnica de elección para la valoración de neoplasias, a través de secuencias potenciadas en T1 y T2 en los diferentes planos del espacio, secuencia potenciada en difusión y estudio dinámico postcontraste, destacando las técnicas de supresión grasa.A través de los estudios de RM realizados en nuestro Centro se pudo obtener una visión completa de la anatomía y patología glandular en la mayoría de los casos, incluyendo controles a largo plazo de pacientes con enfermedad conocida, optimizando las exploraciones mediante el empleo de secuencias con saturación grasa y de medio de contraste, con la ventaja añadida de ausencia de radiación ionizante. No obstante en algunas ocasiones no fue posible realizar un diagnóstico exacto por imagen y fue necesario recurrir a la biopsia.

  2. Carcinoma medular de tiroides metastásico en mama en una paciente con diagnóstico clínico de neoplasia endocrina múltiple subtipo 2B: reporte de un caso

    OpenAIRE

    D’Angelo Piaggio, Lorenzo; Echecopar Sabogal, José; Chanamé Baca, Diego M.; Teruya Gibu, Alberto

    2016-01-01

    El carcinoma medular de tiroides (CMT) es un tipo de neoplasia maligna infrecuente, con alto índice metastásico. Se presenta como un solo nódulo en más del 70% de los casos, y los principales órganos de metástasis a distancia son el hígado, el pulmón y el hueso. La metástasis en mama es rara, debido a que dentro de los tumores mamarios, solo entre el 0.2-1.3% son secundarios. El CMT se relaciona íntimamente con la neoplasia endocrina múltiple subtipo 2B (NEM2B), la cual es un desorden autosóm...

  3. Diagnóstico de febre catarral maligna em bovinos do Uruguai

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    Marcela Preliasco

    2013-01-01

    Full Text Available Foi realizado um estudo retrospectivo de 14 focos de febre catarral maligna (FCM em bovinos, detectados nos anos de 1999-2011, a partir dos arquivos da Seção Anatomia Patológica da Divisão de Laboratórios Veterinários (DILAVE "Miguel C. Rubino" Montevideo. Foram analisados os dados epidemiológicos, apresentação clínica e lesões macroscópicas e histopatológicas. Para a detecção do herpesvírus ovino tipo 2 (OvHV-2 foi utilizada a técnica de PCR sobre as amostras do sistema nervoso central de bovinos de 12 focos. Os surtos ocorreram principalmente nos meses de primavera e verão, na região norte do país. Em 64% (9/14 dos focos ocorreram episódios individuais da enfermidade, enquanto que os casos coletivos foram 5, nos quais a morbidade e mortalidade oscilaram entre 2% e 5%, sendo a letalidade 100% em todos os relatos. Em 50% dos surtos foi confirmado o contato direto entre bovinos e ovinos, enquanto no restante não havia tal informação. Clinicamente predominaram os sinais de opacidade bilateral da córnea, conjuntivite, secreção nasal e ocular mucopurulenta, assim como a síndrome nervosa. Os achados de necropsia mais frequentes foram opacidade bilateral da córnea e lesões inflamatórias nas mucosas. Os achados histopatológicos caracterizaram-se por panvasculite necrótica sistêmica. Foi possível detectar o agente etiológico por PCR em 5 dos 12 casos analisados.

  4. Utilidad de citometria de flujo en el diagnóstico y seguimiento de neoplasias hematopoyéticas

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    C. Saavedra

    2006-04-01

    Full Text Available La aplicación de la citometría de flujo en hematología clínica y en particular en el diagnóstico de las neoplasias es uno de los campos más fascinantes del desarrollo del laboratorio en las últimas dos décadas.

  5. Intercostal schwannoma simulating pulmonary Neoplasia

    OpenAIRE

    1998-01-01

    RESUMO – Schwannoma é uma neoplasia mesenquimal, usualmente solitária, encontrada no mediastino, retroperitônio ou pelve, sendo rara sua apresentação na parede torácica. OBJETIVO. Relatar o caso de um paciente masculino, tabagista, com um nódulo pulmonar direito com características de malignidade, detectado em radiografia de tórax de rotina, cujo diagnóstico anatomopatológico foi de schwannoma benigno de nervo intercostal. MÉTODOS. Revisaram-se os dados referentes ao quadro clínico, exames la...

  6. PROSTATIC INTRAEPITHELIAL NEOPLASIA: HISTOLOGICAL ASSOCIATIONS

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    E. N. Gorbunova

    2009-01-01

    Full Text Available The authors determined the detection rates of prostatic intraepithelial neoplasia (PIN in 2317 patients with benign prostatic hyperplasia (BPH and prostate cancer (PC; and those of chronic prostatitis and fibrosis in patients with PIN, BPH, or PC. There was no difference in median age between the groups. PC was found to be more concurrent with PIN 2 than with BPH. The severer inflammation or fibrosis is, more likely there is a concomitance with PIN 2 or PC. There is evidence for the theory of inflammation is a factor of carcinogenesis. Prostatic fibrosis may also initiate carcinogenesis.

  7. PROSTATIC INTRAEPITHELIAL NEOPLASIA: HISTOLOGICAL ASSOCIATIONS

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    E. N. Gorbunova

    2014-08-01

    Full Text Available The authors determined the detection rates of prostatic intraepithelial neoplasia (PIN in 2317 patients with benign prostatic hyperplasia (BPH and prostate cancer (PC; and those of chronic prostatitis and fibrosis in patients with PIN, BPH, or PC. There was no difference in median age between the groups. PC was found to be more concurrent with PIN 2 than with BPH. The severer inflammation or fibrosis is, more likely there is a concomitance with PIN 2 or PC. There is evidence for the theory of inflammation is a factor of carcinogenesis. Prostatic fibrosis may also initiate carcinogenesis.

  8. Oral tumors in dogs: clinical aspects, exfoliative cytology and histopathology Neoplasias orais em cães: avaliação dos aspectos clínicos, histopatologia e citologia esfoliativa

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    Cláudia Ronca Felizzola

    1999-09-01

    Full Text Available In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma; 36.92% benign odontogenic tumors (25.38% peripheral odontogenic fibroma, 10.0% ossifyng fibroma and 1.54% odontoma in addition to 3.85% benign non-odontogenic tumors (1.54% fibroma, 0.77% plasmocytoma, 0.77% pilomatrixoma and 0.77% giant tumor cells. These results permit us to conclude that exfoliative cytology was an efficient, safe, quick and noninvasive method and could be used for early evaluation of oral cancer.Objetivou-se o estudo comparativo em tumores de cavidade bucal de animais de espécie canina de acordo com sexo, faixa etária, raça, aspectos clínicos, citologia esfoliativa e histopatologia, para estabelecer diagnóstico dessas neoplasias, tendo sido utilizados 130 cães, encaminhados ao Hospital Veterinário (HOVET da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Os resultados obtidos na citologia esfoliativa foram: 100% de negativos para neoplasias benignas não odontogênicas; 97,91% de negativos para neoplasias benignas odontôgenicas e 77,92% de positivos para neoplasias malignas. Obtiveram-se os seguintes resultados no exame histopatológico: neoplasias malignas - 59,23% (melanoma 33,08%, carcinoma epidermóide 9,23%, osteossarcoma 5,38%, fibrossarcoma 2,31%, angiossarcoma 2

  9. CRYOTHERAPY IN CERVICAL INTRAEPITHELIAL NEOPLASIA

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    Naina Kumar

    2013-01-01

    Full Text Available Cryotherapy is a time proven ablative method of treating lower grades of cervical dysplasia. It  is done using compressed CO2 or N2O refrigerant with the aim of creating an ice ball with a depth of freeze denoted by a peripheral margin of 4-5 mm of frost. It is performed using a double freeze or single freeze technique. Currently the double freeze technique of cryotherapy is an accepted treatment for mild and focal moderate dysplasia of the uterine cervix. The success of cryotherapy is determined by five factors : patient anatomy, pathology, equipment, technique and physician skill. Here we have a brief review of cryotherapy as an effective modality in treatment of lower grades of cervical intraepithelial neoplasias.

  10. Multiple endocrine neoplasia type 2.

    Science.gov (United States)

    Lodish, Maya

    2013-01-01

    Multiple endocrine neoplasia type 2 (MEN2) is an autosomal-dominant cancer syndrome characterized by variable penetrance of medullary thyroid carcinoma(MTC), pheochromocytoma (PHEO), and primary hyperparathyroidism (PHPT). MEN2 consists of two clinical subtypes, MEN2A and MEN2B. Familial medullary thyroid cancer is now viewed as a phenotypic variant of MEN2A with decreased penetrance for PHEO and PHPT rather than a distinct entity. All subtypes are caused by gain-of-function mutations of the RET proto-oncogene. Genotype-phenotype correlations exist that help predict the presence of other associated endocrine neoplasms as well as the timing of thyroid cancer development. Recognition of the clinical entity in individuals and families at risk of harboring a germline RET mutation is crucial for the management and prevention of associated malignancies. Recent guidelines released by the American Thyroid Association regarding the management of MTC will be summarized in this chapter.

  11. Radiology of gestational trophoblastic neoplasia

    Energy Technology Data Exchange (ETDEWEB)

    Allen, S.D. [Department of Radiology, Charing Cross Hospital, Hammersmith Hospitals NHS Trust, London (United Kingdom); Lim, A.K. [Department of Radiology, Charing Cross Hospital, Hammersmith Hospitals NHS Trust, London (United Kingdom); Seckl, M.J. [Department of Medical Oncology, Charing Cross Hospital, Hammersmith Hospitals NHS Trust, London (United Kingdom); Blunt, D.M. [Department of Radiology, Charing Cross Hospital, Hammersmith Hospitals NHS Trust, London (United Kingdom); Mitchell, A.W. [Department of Radiology, Charing Cross Hospital, Hammersmith Hospitals NHS Trust, London (United Kingdom)]. E-mail: amitchell@hhnt.org

    2006-04-15

    Gestational trophoblastic neoplasia (GTN) encompasses a broad spectrum of placental lesions from the pre-malignant hydatidiform mole (complete and partial) through to the malignant invasive mole, choriocarcinoma and rare placental site trophoblastic tumour (PSTT). Ultrasound remains the radiological investigation of choice for initial diagnosis, and it can also predict invasive and recurrent disease. Magnetic resonance imaging is of invaluable use in assessing extra-uterine tumour spread, tumour vascularity, and overall staging. Positron emission tomography and computed tomography undoubtedly have a role in recurrent and metastatic disease, while angiography has a place in disease and complication management. This review will describe the relevant pathophysiology and natural history of GTN, and the use of imaging techniques in the diagnosis and management of these conditions.

  12. Cross-sectional imaging of gastric neoplasia

    Energy Technology Data Exchange (ETDEWEB)

    Hargunani, R. [Royal Free Hampstead NHS Trust (United Kingdom)], E-mail: rikin@doctors.org.uk; Maclachlan, J. [Royal Free Hampstead NHS Trust (United Kingdom); Kaniyur, S. [Lister Hospital, East and North Hertfordshire NHS Trust (United Kingdom); Power, N. [Barts and The London NHS Trust (United Kingdom); Pereira, S.P. [University College London Hospitals NHS Foundation Trust (United Kingdom); Malhotra, A. [Royal Free Hampstead NHS Trust (United Kingdom)

    2009-04-15

    The detection of gastric neoplasia has traditionally been limited to barium examination and direct visualization at endoscopy. The rapid development of techniques such as multidetector computed tomography (MDCT) and endoscopic ultrasound (EUS) has resulted in more accurate diagnosis and staging of gastric neoplasia. In this review we describe the normal anatomy of the stomach with multi-modality illustrations and review the imaging manifestations of gastric neoplasia, including adenocarcinoma, lymphoma, neuroendocrine and gastro-intestinal stromal tumours. We also describe the optimal techniques for up-to-date and accurate gastric imaging, outlining the role of MDCT and EUS.

  13. Inflammatory Bowel Disease and Cervical Neoplasia

    DEFF Research Database (Denmark)

    Rungoe, Christine; Simonsen, Jacob; Riis, Lene

    2015-01-01

    BACKGROUND & AIMS: We examined the risk of cervical neoplasia (dysplasia or cancer) in women with ulcerative colitis (UC) or Crohn's disease (CD). We also calculated the reverse, the risk for diagnosis with cervical neoplasia before development of inflammatory bowel disease (IBD). METHODS: We...... with IBD were assessed by Cox proportional hazards regression analysis. Odds ratios (ORs) of cervical neoplasia before diagnosis of IBD were calculated by using conditional logistic regression. RESULTS: Women with CD underwent cervical cancer screening as often as women in the general population (IRR, 0...

  14. Caracterización de la neoplasia intraepitelial cervical en mujeres atendidas en el policlínico Jimmy Hirzel

    OpenAIRE

    Luisa Margarita Sánchez Alarcón; Odalis Alarcon Chang; Annia Saavedra Díaz; Edita Ros Garcés; Norbelys Moreno Jeréz

    2015-01-01

    Fundamento: el cáncer de cuello uterino es, después del cáncer de mama, el que más frecuentemente afecta a la mujer. La detección y tratamiento temprano de las neoplasias intraepiteliales cervicales garantizan la calidad de vida ante esta afección. Objetivos: caracterizar a las pacientes con neoplasias intraepiteliales cervicales que son atendidas en el policlínico “Jimmy Hirzel” en el municipio Bayamo, provincia Granma, en el período comprendido entre enero y diciembre de 2013. Métodos: se r...

  15. Osteopetrose maligna: transplante de medula óssea Malignant osteopetrosis: bone marrow transplantation

    Directory of Open Access Journals (Sweden)

    Maria L. Borsato

    2008-04-01

    Full Text Available A osteopetrose é uma osteopatia hereditária caracterizada pela deficiência na reabsorção óssea que ocorre por disfunção dos osteoclastos. Com o acúmulo de material osteóide que oblitera o canal medular, ocorre hematopoiese extramedular (hepato-esplenomegalia, obliteração dos forames dos nervos cranianos (cegueira, surdez, paralisias faciais, macrocefalia, protusão da fronte, hipertelorismo, exoftalmo, aumento da pressão intracraniana, retardo na erupção dentária, atraso no crescimento, atraso no desenvolvimento neuropsicomotor, e a morte ocorre precocemente nos primeiros anos de vida. A única alternativa terapêutica curativa é o transplante de medula óssea (TMO de doador HLA idêntico, pois restabelece a hematopoiese e a função monócito-macrófago, com melhora das lesões ósseas e anormalidades hematopoiéticas, embora não reverta as alterações sensoriais já instaladas. Os autores relatam casos de duas crianças portadoras de osteopetrose maligna submetidas ao transplante de medula óssea com sucesso. A primeira encontra-se no dia +1260 do TMO, com melhora evidente da radiologia esquelética, sem progressão das deficiências neurológicas que apresentava, e com biópsia óssea sem sinais de osteopetrose. O segundo paciente encontra-se no dia + 700, com sinais de reabsorção óssea e sem progressão dos danos neurológicos. Os autores chamam a atenção para a necessidade de diagnóstico precoce da osteopetrose e o rápido encaminhamento para o transplante de medula óssea antes da instalação de seqüelas neurológicas definitivas.Osteopetrosis is an inherited disorder characterized by the inability to reabsorb and remodel bone due to osteoclast dysfunction. The encroachment by bone and mineralized cartilage of the medullary cavities leads to extramedullary hematopoiesis (hepatosplenomegaly and cranial-nerve foramina leads to blindness, auditory nerve damage, and occulomotor and facial nerve palsies. Defective

  16. Caracterización de la neoplasia intraepitelial cervical en mujeres atendidas en el policlínico Jimmy Hirzel

    Directory of Open Access Journals (Sweden)

    Luisa Margarita Sánchez Alarcón

    2015-06-01

    Full Text Available Fundamento: el cáncer de cuello uterino es, después del cáncer de mama, el que más frecuentemente afecta a la mujer. La detección y tratamiento temprano de las neoplasias intraepiteliales cervicales garantizan la calidad de vida ante esta afección. Objetivos: caracterizar a las pacientes con neoplasias intraepiteliales cervicales que son atendidas en el policlínico “Jimmy Hirzel” en el municipio Bayamo, provincia Granma, en el período comprendido entre enero y diciembre de 2013. Métodos: se realizó un estudio descriptivo, retrospectivo, en un universo de 3450 pacientes a las que se realizó citología vaginal en el período de referencia; la muestra fueron las 55 mujeres cuyos exámenes resultaron positivos. Se midieron variables como tipo de neoplasia, edad, inicio de las relaciones sexuales, presencia de cervicitis, sepsis vaginal y hábitos de fumar. Los datos se procesaron por conteo simple, se tabularon utilizando valores absolutos y porcentajes. Resultados: la presencia de la neoplasia intraepitelial cervical fue de un 1,6 %, predominando las de bajo grado (NIC I. El grupo de edad más afectado fue el de 36 a 45 años. Otros factores asociados encontrados con relativa frecuencia, en orden decreciente, fueron: sepsis vaginal, inicio de las relaciones sexuales entre 15-20 años, cervicitis y el hábito de fumar. Conclusiones: existe poca incidencia de las neoplasias intraepiteliales en el área de salud y período estudiados.

  17. Non‐operative breast pathology: lobular neoplasia

    OpenAIRE

    2006-01-01

    Lobular neoplasia is a relatively uncommon lesion, which is frequently diagnosed in biopsy specimens taken for other reasons. Although the histological features of this lesion are well known, its biological significance as a “risk indicator” or “breast cancer precursor” has been a matter of debate. This review provides an update on recent clinicopathological and molecular data on lobular neoplasia and how these have changed the way these lesions are perceived and, most importantly, managed. F...

  18. Actualización del diagnóstico y tratamiento de la neoplasia intraepitelial vulvar.

    OpenAIRE

    Rafael E. Pérez Castro

    2011-01-01

    La Neoplasia Intraepitelial Vulvar (NIV) constituye lesiones potencialmente premalignas del epitelio escamoso de la vulva con diversos grados de diferenciación celular y maduración. En el aspecto histológico son hiperplasia de las células basales y parabasales, además tienen características genéticas morfológicas y metabólicas similares a las células cancerosas. Son etapas previas a la enfermedad. Generalmente las NIV se diagnostican como lesiones de alto grado (NIV I, II y III) o carcinoma i...

  19. Alterações citogenéticas em portadores de desordens potencialmente malignas e carcinoma oral

    OpenAIRE

    Feliciano, Luciana Maria [UNESP

    2011-01-01

    A cavidade oral está constantemente exposta a traumas físicos, químicos e biológicos que fazem com que os tecidos respondam sob várias formas de manifestações clínicas. As lesões mais comuns são as traumáticas, as fúngicas, as virais, as bacterianas e as consideradas de etiologia multifatorial, como o câncer, as úlceras aftosas recorrentes, o líquen plano e as leucoplasias, sendo as duas últimas classificadas como desordens potencialmente malignas (DPM). As DPM e o câncer de boca apresentam a...

  20. Evolución de la mortalidad y de los años de vida perdidos prematuramente relacionados con el consumo de alcohol en las Islas Canarias (1980-1998

    Directory of Open Access Journals (Sweden)

    Bello L.M.

    2003-01-01

    Full Text Available Objetivo: Describir la mortalidad y los años de vida perdidos prematuramente (AVPP relacionados con el alcohol en las Islas Canarias durante el período 1980-1998. Métodos: Las defunciones por edad, sexo y causa desde 1980 a 1998 se obtuvieron del Instituto Nacional de Estadística (Movimiento Natural de la Población. Se calculó la proporción de muertes relacionadas con el alcohol para cada año, sexo y grupo de edad a partir de la fracción atribuible poblacional propuesta por los Centers for Disease Control (Estados Unidos. Para cada categoría diagnóstica, los años de vida perdidos prematuramente relacionados con el alcohol fueron calculados multiplicando las defunciones por la fracción poblacional en grupos quinquenales de edad para ambos sexos hasta la edad de 65 años. Resultados: Durante el período 1980-1998, el número de fallecimientos por causas relacionadas con el alcohol fue de 12.614, con un promedio del 6,4% anual y una razón varón/mujer de aproximadamente 2:1. Las neoplasias malignas, las enfermedades digestivas y los accidentes no intencionales relacionados con el alcohol presentan las mayores tasas de mortalidad y de AVPP tanto en varones como en mujeres; en particular, los accidentes no intencionales generan AVPP por encima de las otras causas, lo que supone el 50,6% del total de AVPP por causas relacionadas con el alcohol en varones y el 55,5% en mujeres. Durante el período de estudio, la cirrosis hepáticas y otras enfermedades crónicas del hígado (CIE 571 van decreciendo paulatinamente en los varones y se mantienen en las mujeres. Conclusiones: En el ámbito y período de estudio (Islas Canarias, 1980-1998, se ha observado que el porcentaje de fallecidos por causas relacionadas con el alcohol es elevado, incluyendo la mortalidad por cirrosis hepática. Por tanto, sería necesario potenciar el desarrollo de estrategias educativas y otras dirigidas para controlar su consumo, sobre todo en los jóvenes.

  1. Fluorescence detection of esophageal neoplasia

    Science.gov (United States)

    Borisova, E.; Vladimirov, B.; Avramov, L.

    2008-06-01

    White-light endoscopy is well-established and wide used modality. However, despite the many technological advances that have been occurred, conventional endoscopy is suboptimal and usually detects advanced stage lesions. The limitations of standard endoscopy initiate development of spectroscopic techniques, additional to standard endoscopic equipment. One of the most sensitive approaches is fluorescence spectroscopy of gastrointestinal mucosa for neoplasia detection. In the recent study delta-aminolevulinic acid/Protoporphyrin IX (5-ALA/PpIX) is used as fluorescent marker for dysplasia and tumor detection in esophagus. The 5-ALA is administered per os six hours before measurements at dose 20 mg/kg weight. Excitation source has max of emission at 405 nm and light is delivered by the standard light guide of the endoscopic equipment. Through endoscopic instrumental channel a fiber is applied to return information about fluorescence to microspectrometer. Spectral features observed during endoscopic investigations could be distinct as the next regions: 450-630 nm region, where tissue autofluorescence is observed; 630-710 nm region, where fluorescence of PpIX is clearly pronounced; 530-580 nm region, where minima in the autofluorescence signal are observed, related to reabsorption of blood. The lack of fluorescence peaks in the red spectral area for normal mucosa is an indication for selective accumulation of 5-ALA/PpIX only in abnormal sites Very good correlation between fluorescence signals and histology examination of the lesions investigated is achieved.

  2. Multiple endocrine neoplasia type 1

    Directory of Open Access Journals (Sweden)

    R V Thakker

    2012-01-01

    Full Text Available Multiple endocrine neoplasia type 1 (MEN1 is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may also develop carcinoid tumors, adrenocortical tumors, facial angiofibromas, collagenomas, and lipomas. MEN1 is an autosomal-dominant disorder, due to mutations in the tumor suppressor gene MEN1, which encodes a 610 amino acid protein, menin. Thus, the finding of MEN1 in a patient has important implications for family members because first-degree relatives have a 50% risk of developing the disease and can often be identified by MEN1 mutational analysis. Patients with MEN1 have a decreased life-expectancy and the outcomes of current treatments, which are generally similar to that for the respective tumors occurring in non-MEN1 patients, are not as successful because of multiple tumors, which may be larger, more aggressive, and resistant to treatment, and the concurrence of metastases. The prognosis for MEN1 patients might be improved by pre-symptomatic tumor detection and undertaking treatment specific for MEN1-tumors. Thus, it is recommended that MEN1 patients and their families should be cared for by multi-disciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.

  3. Metabolismo del hemo y neoplasias

    OpenAIRE

    Casas, Adriana Gabriela

    1996-01-01

    La Terapia Fotodinámica del cáncer (TFD) es un tratamiento que se basa en la acumulación selectiva de un fotosensibilizante en las células tumorales. Este, luego de ser excitado por acción de la luz roja, desencadena una serie de reacciones mediadas por radicales libres, que finalmente destruyen el tejido. El empleo del ácido 5-aminolevúlico (ALA) como precursor de la síntesis de porfirinas, ha cobrado especial interés en los últimos años tanto en la TFD usando las porfirinas como fotosensibi...

  4. Otitis maligna del diabético: nuestra experiencia y revisión de la literatura Malignant otitis of the diabetic: our experience and literature review

    Directory of Open Access Journals (Sweden)

    Pedro P. Morales Hechevarría

    2002-04-01

    Full Text Available Se realizó un estudio transversal en 22 diabéticos (18 tipo 2 y 4 tipo 1, mayores de 15 años, afectados de otitis maligna del diabético, para conocer las características clínicas y la evolución de estos pacientes. Se les confeccionó historia clínica completa (endocrinólogo y otológica minuciosa (otorrinolaringólogo. Se precisó la edad, sexo, tipo de tratamiento y tiempo de evolución de la DM, valores promedio de las glucemias, resultado del estudio bacteriológico de la secreción ótica, e imagenológico, así como síntomas y signos dependientes de esa otitis, complicaciones y resultado del tratamiento. Se empleó tratamiento insulínico intensivo y antibioticoterapia específica. La Pseudomona aeruginosa fue el germen causal más frecuente. La otalgia, el granuloma del conducto auditivo externo y el compromiso de los pares craneales (VII, IX y X fueron frecuentes. Se comprobó que más de la mitad de los pacientes egresaron mejorados o curados, no hubo fallecidos. Se observaron secuelas en 4 pacientes. Se presentó mayor frecuencia de OMD en los pacientes con DM tipo 2 con evolución mayor de 10 años. La causa más frecuente de indicación quirúrgica fue el granuloma del CAE. Se observaron las secuelas en 4 pacientes (18,2 %. Se concluyó que el diagnóstico precoz de la OMD, el tratamiento insulínico intensivo y una terapia con antibióticos adecuada puede disminuir significativamente la estadía hospitalaria, las secuelas y la mortalidad en estos pacientes.A cross-sectional study was conducted among 22 diabetics (18 type 2 and 4 type 1 over 15 that were affected by malignant otitis of the diabetic in order to know the clinical characteristics and evolution of these patients. A complete medical history (endocrinologist and a detailed otological history (ear, nose and throat specialist were made. Age, sex, type of treatment and time of evolution of diabetes mellitus, mean values of glycaemia, the result of the bacteriological

  5. Multiple endocrine neoplasia type 1

    Directory of Open Access Journals (Sweden)

    Luzi Ettore

    2006-10-01

    Full Text Available Abstract Multiple Endocrine Neoplasia type 1 (MEN1 is a rare autosomal dominant hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine pancreas and anterior pituitary, and characterised by a very high penetrance and an equal sex distribution. It occurs in approximately one in 30,000 individuals. Two different forms, sporadic and familial, have been described. The sporadic form presents with two of the three principal MEN1-related endocrine tumours (parathyroid adenomas, entero-pancreatic tumours and pituitary tumours within a single patient, while the familial form consists of a MEN1 case with at least one first degree relative showing one of the endocrine characterising tumours. Other endocrine and non-endocrine lesions, such as adrenal cortical tumours, carcinoids of the bronchi, gastrointestinal tract and thymus, lipomas, angiofibromas, collagenomas have been described. The responsible gene, MEN1, maps on chromosome 11q13 and encodes a 610 aminoacid nuclear protein, menin, with no sequence homology to other known human proteins. MEN1 syndrome is caused by inactivating mutations of the MEN1 tumour suppressor gene. This gene is probably involved in the regulation of several cell functions such as DNA replication and repair and transcriptional machinery. The combination of clinical and genetic investigations, together with the improving of molecular genetics knowledge of the syndrome, helps in the clinical management of patients. Treatment consists of surgery and/or drug therapy, often in association with radiotherapy or chemotherapy. Currently, DNA testing allows the early identification of germline mutations in asymptomatic gene carriers, to whom routine surveillance (regular biochemical and/or radiological screenings to detect the development of MEN1-associated tumours and lesions is recommended.

  6. Fractal analysis of cervical intraepithelial neoplasia.

    Directory of Open Access Journals (Sweden)

    Markus Fabrizii

    Full Text Available INTRODUCTION: Cervical intraepithelial neoplasias (CIN represent precursor lesions of cervical cancer. These neoplastic lesions are traditionally subdivided into three categories CIN 1, CIN 2, and CIN 3, using microscopical criteria. The relation between grades of cervical intraepithelial neoplasia (CIN and its fractal dimension was investigated to establish a basis for an objective diagnosis using the method proposed. METHODS: Classical evaluation of the tissue samples was performed by an experienced gynecologic pathologist. Tissue samples were scanned and saved as digital images using Aperio scanner and software. After image segmentation the box counting method as well as multifractal methods were applied to determine the relation between fractal dimension and grades of CIN. A total of 46 images were used to compare the pathologist's neoplasia grades with the predicted groups obtained by fractal methods. RESULTS: Significant or highly significant differences between all grades of CIN could be found. The confusion matrix, comparing between pathologist's grading and predicted group by fractal methods showed a match of 87.1%. Multifractal spectra were able to differentiate between normal epithelium and low grade as well as high grade neoplasia. CONCLUSION: Fractal dimension can be considered to be an objective parameter to grade cervical intraepithelial neoplasia.

  7. LASER EN EL TRATAMIENTO DE LA NEOPLASIA INTRAEPITELIAL DE VAGINA

    OpenAIRE

    Yazigi I.,Roberto; Rodríguez A.,Tulio; Contreras M,Luis

    2006-01-01

    Objetivo: Presentar la experiencia en el tratamiento de la neoplasia intraepitelial de vagina (VAIN) utilizando el láser de CO2. Método: 19 pacientes con el diagnóstico histológico de VAIN fueron tratadas con esta técnica. Se utilizó un diámetro del punto de helio-neón de 1,5 a 2 mm y un poder de densidad de 400 a 500 W/cm². Toda la lesión detectable más un margen de al menos 5 mm de tejido circundante aparentemente normal fueron vaporizados a una profundidad de 2 mm. Resultados: 12 de las 14...

  8. Intervenciones para el tratamiento de la neoplasia intraepitelial anal y la prevención de conductas sexuales de riesgo

    OpenAIRE

    Macaya Pascual, Antoni

    2016-01-01

    La prevalencia de neoplasia intraepitelial del canal anal (NICA) está incrementándose, principalmente en hombres que tienen sexo con hombres VIH+. No hay consenso sobre el manejo óptimo de la NICA, ni se ha procedido a un estudio global sobre la evidencia disponible del efecto preventivo que puedan tener las distintas intervenciones conductuales (IC). Objetivos: Sintetizar y analizar cualitativamente la evidencia disponible sobre la eficacia de las intervenciones terapéuticas en la NICA y ...

  9. Multiple endocrine neoplasia: the Chilean experience

    Directory of Open Access Journals (Sweden)

    René E. Diaz

    2012-01-01

    Full Text Available Multiple endocrine neoplasia (MEN types 1 and 2 are genetic diseases that are inherited as autosomal traits. The major clinical manifestations of multiple endocrine neoplasia type 1 include the so-called "3 P's": parathyroid, pituitary, and pancreatic tumors, including gastroenteroneuroendocrine tumors. Genetic testing can be performed on patients and the potential carriers of the menin gene mutation, but the genotype-phenotype correlation in multiple endocrine neoplasia type 1 is less straightforward than multiple endocrine neoplasia type 2. Most likely, the main advantage of genetic testing in MEN1 is to exclude from further studies those who are negative for the genetic mutation if they belong to a family with a known history of MEN1. In Chile, we started with rearranged during transfection proto-oncogene genetic testing (MEN2 15 years ago. We carried out a prophylactic total thyroidectomy to prevent medullary thyroid carcinoma in a three-year-old girl who presented with microscopic medullary thyroid carcinoma. More than 90% of the individuals who tested positive using a genetic test achieved a biochemical cure compared with only 27% of patients who receive a clinical diagnosis. Mutations are mainly located in exon 11; the most common is C634W, rather than C634R. Hypertensive crisis was the cause of death in three patients, and extensive distant metastases occurred in nine (including two patients with multiple endocrine neoplasia type 2B of 14 patients. Earlier recognition of medullary thyroid carcinoma and the other features of the disease, especially pheochromocytoma, will improve the survival rate of patients with multiple endocrine neoplasia.

  10. Neoplasia no sítio da colostomia: relato de três casos e revisão da literatura

    Directory of Open Access Journals (Sweden)

    Valdemir José Alegre Salles

    2006-03-01

    Full Text Available Carcinomas raramente ocorrem no sitio da colostomia. O risco para o desenvolvimento de neoplasia maligna é semelhante a qualquer outro segmento colônico, porém se a ressecção inicial foi devida a câncer, há um significativo aumento na incidência de tumor metacrônico quando comparado à população em geral. A incidência do carcinoma metacrônico colônico é geralmente de 3 a 5%. A recorrência do tumor primário, quando associada à ostomia, pode se manifestar com sangramento ou obstrução. Relatamos três doentes com tumor no sitio da colostomia, sua manifestação clínica e a conduta terapêutica adotada.Carcinomas rarely occur at the site of a colostomy. Colostomies are risk for malignancy, just as in any other portion of the colon. If the initial resection was for cancer, then the risk of metachronous colon adenocarcinoma is significantly higher than for the general population. Metachronous colorectal carcinoma occurs from 0.1 to 3.6 percent of patients who undergo surgery for colorectal carcinoma and the recurrence of the primary bowel malignancy that necessitated the stoma may present with signs of bleeding or obstruction. We report three cases of this rare neoplasia occurring at the site of a colostomy, and we review the literature.

  11. Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas

    Directory of Open Access Journals (Sweden)

    Ana Carolina Bernardes Terzian

    2007-04-01

    Full Text Available A apoptose e a proliferação celular possuem uma participação importante na tumorigênese, determinando o crescimento tumoral e consequentemente sua agressividade. O presente estudo teve como objetivo avaliar a ocorrência da apoptose associada a proliferação celular em neoplasias mamárias em cadelas e a elas a evolução clínica do paciente. Setenta animais foram submetidos à exérese cirúrgica do tumor, sendo este submetido ao diagnóstico histopatológico e marcação imuno-histoquímica para caspase-3 e Ki-67. Estes marcadores de apoptose e proliferação celular demonstraram grande expressão nas neoplasias malignas, principalmente nos carcinomas, considerado o mais maligno dos tumores. Estes resultados corroboram os dados da literatura e contribuem para um prognóstico tumoral criterioso que complementa a classificação tumoral existente proporcionando uma melhor e maior sobrevida devido a uma adequação do procedimento terapêutico de cada paciente.

  12. Uso tópico do inteferon alfa-2b para neoplasia escamosa da superficie ocular em um caso de paciente com xeroderma pigmentoso

    Directory of Open Access Journals (Sweden)

    Nayara Queiroz Cardoso Pinto

    Full Text Available Resumo Relato de um caso clínico de Xeroderma Pigmentoso com carcinoma espinocelular de conjuntiva bilateral que apresentou regressão importante das dimensões tumorais com o uso de Interferon alfa-2b tópico. Relato de caso: Paciente feminina com Xeroderma Pigmentoso em estágio avançado, com ausência de pele sadia, tendo sido submetida a cerca de 60 exéreses de lesões de pele malignas. A paciente compareceu com tumoração conjuntival em ambos os olhos, correspondendo a carcinoma espinocelular de conjuntiva e neoplasia intraepitelial de conjuntiva em olho esquerdo. Devido as dificuldades cirúrgicas, alta taxa de recidiva e elevada probabilidade de formação de simbléfaro foi-se iniciado terapêutica com Interferon alfa-2beta 1.000.000 unidades tópico, obtendo-se bons resultados com importante regressão do tamanho da lesão e resolução dos sintomas. Conclusão: O uso tópico de interferon alfa-2beta em neoplasia escamosa de conjuntiva, mostrou-se uma boa opção terapêutica em situações de elevado risco cirúrgico e de complicações pós operatórias.

  13. Enfermeiras no atendimento ambulatorial a mulheres com feridas neoplásicas malignas nas mamas

    OpenAIRE

    Flávia Firmino; Laísa Figueiredo Ferreira Lós Alcântara

    2014-01-01

    Los objetivos de esta investigación fueron analizar el relato de enfermeros que realizan curas en heridas neoplásicas de mujeres afectadas por cáncer de mama, e trazar las contribuciones a la práctica de la atención de enfermería. Investigación cualitativa, llevada a cabo en noviembre de 2010, con entrevistas semiestructuradas y análisis temático, con cinco enfermeras que actuaban en área ambulatoria de hospital público del Rio de janeiro, Brasil, especializado en tratamiento oncológico. Fuer...

  14. Neurocutaneous spectrum of multiple endocrine neoplasia-1

    Directory of Open Access Journals (Sweden)

    Shireen Furtado

    2012-01-01

    Full Text Available Multiple endocrine neoplasia type I or Wermer syndrome is characterized by primary hyperparathyroidism, enteropancreatic endocrine tumor, and a pituitary pathology. A 35-year-old male presented with visual field defects, hyperprolactinemia, and hypogonadism. He also had multiple infraumbilical skin-colored nodules. A syndromal association of Wermer syndrome was derived using the dermal, pituitary, parathyroid, and gastrointestinal hormonal manifestations of the tumor. The radiological and histological findings of lesion which underwent biopsy are discussed. The presence of collagenomas, lipomas, and hypopigmented macules in a patient with neuroendocrine symptoms should raise the suspicion of an underlying multiple endocrine neoplasia.

  15. Pregnancy outcomes after chemotherapy for trophoblastic neoplasia

    Directory of Open Access Journals (Sweden)

    MILA TREMENTOSA GARCIA

    Full Text Available SUMMARY Introduction The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms “gestational trophoblastic disease” and “pregnancy outcome”. Results A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. Conclusion The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients.

  16. Anal intraepithelial neoplasia in HIV+ men

    NARCIS (Netherlands)

    Richel, O.

    2014-01-01

    In this thesis we investigated several aspects of anal intraepithelial neoplasia (AIN) in HIV+ men who have sex with men (MSM). This condition has gained clinical interest because of the impressive increase of the anal cancer incidence in HIV+ MSM since the introduction of combination antiretroviral

  17. Risk Factors for Cervical Intraepithelial Neoplasia

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    Estrella de la Caridad Armenteros Espino

    2016-09-01

    Full Text Available Background: cervix cancer constitutes the second cause of death worldwide, with new diagnosis each year. Objective: to determine the risk factors of cervical intraepithelial neoplasia in the municipality of Cruces. Methods: it was developed an analytical research with case and control design from November 2013 to November 2014. The group of cases was formed of the 34 women with this diagnosis. There were selected 64 females from the same environment with the same age for the control group. The data obtained by surveys and clinical records reviews were presented in absolute numbers and percentages. It was used Chi-squared test and odd ratio. Results: 52 % of women with neoplasia were less than 25 years old. Significant differences were found which associate neoplasia with early sexual intercourse, sexually transmitted infections by Papilloma virus, Plane genital condyloma, and the use of oral contraceptive pills. Multiple sex partner was a frequent antecedent. Conclusion: risk factors associated to cervical intraepithelial neoplasia in the group of women studied in the Cruces municipality were early sexual intercourse, mainly before 15 years old, multiple sex partner, sexually communicated diseases and the use of oral contraceptive pills for more than 5 years.

  18. Anal intraepithelial neoplasia in HIV+ men

    NARCIS (Netherlands)

    Richel, O.

    2014-01-01

    In this thesis we investigated several aspects of anal intraepithelial neoplasia (AIN) in HIV+ men who have sex with men (MSM). This condition has gained clinical interest because of the impressive increase of the anal cancer incidence in HIV+ MSM since the introduction of combination antiretroviral

  19. A Left-Sided Prevalence of Lentigo Maligna: A UK Based Observational Study and Review of the Evidence

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    Mark Gorman

    2015-01-01

    Full Text Available Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous melanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and automobile driving patterns. Though left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on, more recent trends indicate a consistent left-sided bias. To clarify reasons for changing trends, a review of the evidence base and LM’s laterality in a UK cohort (99 cases 2000–2011 was conducted for the first time. The strong correlation of left-sided excess, found in both genders (ratios 1.381–1.5, P<0.05  X2 0.841, is congruent with more recent findings. Though evidence indicates that driving position is no longer a risk factor for LM, due most likely to improved car window UV protection, it remains the most commonly attributed cause. Understanding phenomena such as UV lights “scatter effect” or that cumulative exposure may not be a significant risk factor helps rationalize older conclusions that would otherwise appear contradictory. The reasons for left-sided excess remain unclear but may be due to factors requiring further research such as the body’s anatomical/embryological asymmetry.

  20. Investigação do envolvimento dos tipos mais comuns do virus do papiloma humano embasado em estudo clínico e epidemiológico das neoplasias incidentes de cavidade bucal e orofaringe no Distrito Federal

    OpenAIRE

    Leitão, Eliziário Cesar de Vasconcelos

    2011-01-01

    O câncer bucal é uma das neoplasias malignas mais comuns nas regiões de cabeça e pescoço, responsável por elevada incidência na população e altas taxas de óbito. A exposição aos produtos do fumo e álcool tem sido considerada a maior causa de seu desenvolvimento. Todavia, algumas evidências apontam para o fato de que o Vírus do Papiloma Humano (HPV) possa participar em sua gênese e progressão. O objetivo principal deste trabalho é a investigação da presença de sequências gênicas dos tipos circ...

  1. Enfermeiras no atendimento ambulatorial a mulheres com feridas neoplásicas malignas nas mamas

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    Flávia Firmino

    2014-01-01

    Full Text Available Los objetivos de esta investigación fueron analizar el relato de enfermeros que realizan curas en heridas neoplásicas de mujeres afectadas por cáncer de mama, e trazar las contribuciones a la práctica de la atención de enfermería. Investigación cualitativa, llevada a cabo en noviembre de 2010, con entrevistas semiestructuradas y análisis temático, con cinco enfermeras que actuaban en área ambulatoria de hospital público del Rio de janeiro, Brasil, especializado en tratamiento oncológico. Fueron desarrolladas categorías que correspondieron a la práctica de la enfermería ambulatoria; herida neoplásica; y notas para la atención de enfermería. Hay la necesidad de conocimientos específicos en enfermería oncológica, participación profesional, habilidad técnica y autonomía, equipos de discusión terapéutica y atención clínica en interfaz con enfoque paliativo y trabajo colaborativo en equipo.

  2. Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

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    Frederico R. Romero

    2004-08-01

    Full Text Available OBJECTIVE: To assess the incidence of bladder carcinoma infiltrating the prostate and prostate adenocarcinoma in patients undergoing radical cystoprostatectomy due to bladder cancer, as well as to assess if the characteristics of the bladder neoplasia influence the prostatic involvement by this neoplasia. MATERIALS AND METHODS: We retrospectively assessed 60 male patients, who underwent radical cystoprostatectomy between July 1997 and December 2003. Mean age was 66.7 years (40 and 93 years. The product of radical cystoprostatectomies was checked for involvement of urethra and prostate parenchyma by the primary neoplasia, and for the presence of associated prostate adenocarcinoma. Bladder neoplasia characteristics, such as localization, size, multifocality, association with in situ carcinoma and histological grade, were studied in order to assess the possibility of using such characteristics as predictive factors of prostate infiltration by bladder urothelial carcinoma. RESULTS: We observed the presence of 20% of patients with bladder carcinoma infiltrating the prostatic urethra, 23.3% of patients with infiltration of the prostate parenchyma and 28.3% of patients with associate prostate adenocarcinoma, resulting in a total of 55% of patients with prostatic involvement (infiltrative bladder carcinoma and/or adenocarcinoma. We also observed a statistically significant correlation between tumor location in the trigone, the presence of in situ carcinoma and the histological grade of the bladder tumor with prostatic infiltration by the vesical neoplasia. CONCLUSION: The coexistence of prostatic neoplasia in patients operated for bladder neoplasia was frequent in our sample (55%. We observed that the prostatic infiltration by bladder tumors occurs more frequently with tumors located in the trigone, with associated in situ carcinoma and with high histological grade. There was no correlation between neoplastic infiltration of prostate and multifocality

  3. Inmunoterapia activa en el tratamiento de neoplasias hematológicas Active immunotherapy in the treatment of haematological neoplasias

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    S. Inogés

    2004-04-01

    Full Text Available La continua búsqueda de abordajes terapéuticos que mejoren los tratamientos convencionales de las enfermedades neoplásicas junto con el mejor conocimiento del sistema inmunitario ha llevado en los últimos años al desarrollo de la inmunoterapia. Básicamente se pueden distinguir dos formas de inmunoterapia: la inmunoterapia pasiva, que consiste en la transferencia de anticuerpos o células previamente generados in vitro que se dirigen contra el tumor, y la inmunoterapia activa, que pretende activar in vivo el sistema inmunitario e inducirlo a elaborar una respuesta específica contra los antígenos tumorales. Las neoplasias hematológicas, concretamente algunos linfomas B, expresan en su membrana una inmunoglobulina que se considera un verdadero antígeno específico de tumor; por eso estas enfermedades se han convertido en la diana ideal de los tratamientos de inmunoterapia. Las alternativas son muchas, desde las vacunas proteicas que ya han demostrado beneficios clínicos, hasta las de segunda generación, que aprovechan las nuevas técnicas de biología molecular para aumentar la eficacia de las vacunas y conseguir su producción de forma más rápida y menos costosa, pero con las que todavía no hay resultados clínicos definitivos.The continuous search for therapeutic approaches that improve the conventional treatments of neoplasms, together with an improved understanding of the immune system, has led in recent years to the development of Immunotherapy. Basically, a distinction can be made between two forms of immunotherapy: passive immunotherapy, which consists in the transfer of antibodies or cells previously generated in vitro that are directed against the tumour, and active immunotherapy, which attempts to activate in vivo the immune system and induce it to elaborate a specific response against the tumor antibodies. Hematological neoplasms, specifically some B lymphomas, express in their membrane an immunoglobulin that is considered

  4. Neoplasias quísticas del páncreas: Análisis descriptivo y factores predictivos de malignidad

    OpenAIRE

    Adet Caldelari, Ana Celia

    2010-01-01

    Hasta finales del año 1970 el conocimiento de las lesiones quísticas del páncreas era escaso y se diferenciaba principalmente entre lesiones mucinosas y serosas. A partir del año 1980, el desarrollo y el uso extendido de las nuevas técnicas de imagen incrementó el número de lesiones quísticas detectadas. Se describieron nuevas entidades y su origen, morfología y biología fueron mejor conocidas al poder ser estudiadas con más detalle. Las neoplasias quísticas (NQ) del páncreas son relativament...

  5. Anestesia para cirurgia ortopédica em criança com susceptibilidade à hipertermia maligna: relato de caso Anestesia para cirugía ortopédica en niño con susceptibilidad a la hipertermia maligna: relato de caso Anesthesia for orthopedic surgery in a child susceptible to malignant hyperthermia: case report

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    Renato Santiago Gomez

    2003-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Hipertermia maligna é uma miopatia autossômica dominante desencadeada por anestésicos inalatórios e bloqueadores neuromusculares, como halotano e succinilcolina, causando aumento da temperatura que pode ser fatal sem o tratamento imediato. O objetivo deste relato é descrever a conduta anestésica em uma criança susceptível à hipertermia maligna que foi submetida a procedimento cirúrgico ortopédico. RELATO DO CASO: Paciente do sexo feminino, com 3 anos, portadora de luxação congênita do quadril e susceptibilidade à hipertermia maligna, conforme história de anestesia anterior, foi submetida à correção cirúrgica ortopédica sob anestesia geral, com propofol e fentanil, associada à anestesia peridural lombar. A temperatura da paciente foi monitorizada continuamente durante a cirurgia e no período pós-operatório. A paciente apresentou recuperação pós-operatória sem intercorrências e recebeu alta hospitalar após cinco dias. CONCLUSÕES: A combinação de anestesia regional e venosa para o procedimento cirúrgico proposto em paciente com susceptibilidade à hipertermia maligna permitiu a condução anestésica com segurança.JUSTIFICATIVA Y OBJETIVOS: Hipertermia maligna es una miopatia autosómica dominante desencadenada por anestésicos inhalatorios y bloqueadores neuromusculares, como halotano y succinilcolina, causando aumento de la temperatura que puede ser fatal sin el tratamiento inmediato. El objetivo de este relato es describir la conducta anestésica en un niño susceptible a la hipertermia maligna que fue sometida a procedimiento quirúrgico ortopédico. RELATO DEL CASO: Niño, del sexo femenino, con 3 años, portadora de luxación congénita del cuadril (anca y susceptibilidad a la hipertermia maligna, conforme historia de anestesia anterior, fue sometida a la corrección quirúrgica ortopédica bajo anestesia general, con propofol y fentanil, asociada a anestesia peridural lumbar. La

  6. Estudio de los mecanismos de las arritmias cardíacas mediante modelado y procesado robusto digital de señal

    OpenAIRE

    Alonso Atienza, Felipe

    2011-01-01

    Las arritmias cardiacas son alteraciones del funcionamiento eléctrico normal del corazón. Algunas, las arritmias patológicas, son potencialmente malignas y constituyen una de las principales causas de mortalidad en el mundo occidental. Hoy en día, el estudio de los mecanismos de las arritmias patológicas se asienta sobre dos ámbitos de investigación: de un lado, el análisis de señales cardiacas registradas mediante sistemas de captación con electrodos en estudios clínicos y/o experimentales, ...

  7. Neoplasias duodenais primárias: análise de casuística e conduta cirúrgica Primary duodenal tumors: clinicopathologic experience and surgical treatment

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    Sansom Henrique Bromberg

    2000-08-01

    Full Text Available São apresentados 18 casos de neoplasias primárias do duodeno, salientando-se sua raridade e as dificuldades diagnósticas, a despeito dos modernos recursos endoscópicos e de identificação por imagem. A literatura revela que de 1% a 10% de todos os tumores do aparelho digestório se situam no intestino delgado. A localização duodenal é, por isso, muito pouco freqüente, possui sintomatologia indefinida e implica conduta terapêutica mais complexa do que quando o tumor se situa em outros segmentos do intestino delgado. Os sintomas mais comuns são dor, náusea, vômito e hemorragia. A presente casuística consiste de 11 neoplasias malignas e sete benignas. Entre as primeiras o adenocarcinoma é o mais freqüente, sendo os lipomas os mais comuns dos neoplasmas benignos. Enquanto nestes a exérese local representa a conduta mais adequada, a duodenopancreatectomia cefálica foi a cirurgia de escolha nos tumores malignos da segunda porção duodenal, exibindo bons resultados. As lesões malignas da terceira porção e principalmente da quarta porção do duodeno foram tratadas pela ressecção duodenojejunal, também com resultados satisfatórios.Eighteen primary duodenal tumors, including 11 malignant and 8 benign, are presented, stressing their poorly defined natural history and rare frequency. The most common histological diagnosis was adenocarcinoma. There were 6 adenocarcinomas, 2 carcinoids, 1 linfoma, 1 anaplastic and 1 neuroectodermic carcinoma. Benign lesions were occasionally found during a gastroduodenal or a biliary surgery (n = 4 and during the autopsies (n = 3. They consisted of lipomas (n = 4, adenomatous polyps (n = 2 and leiomyoma (n = 1. Concerning the malignant lesions, 6 pancreaticoduodenectomies, 3 duodenojejunal segmentary resection and one paliation consisting of gastrojejunostomy and biopsy were performed. One carcinoid lesion was found at the duodenal bulb during a gastroduodenectomy for a gastric ulcer

  8. Ictericia obstructiva de causa maligna irresecable tras CPRE fallida: factores predictores del pronóstico: Tratamiento mediante drenaje guiado por ecoendoscopia versus drenaje percutáneo

    OpenAIRE

    2016-01-01

    JUSTIFICACIÓN Los pacientes con estenosis biliares de causa maligna presentan un mal pronóstico a corto plazo ya que la mayoría de ellos presentan una enfermedad avanzada en el momento del diagnóstico. Este hecho limita sus posibilidades terapéuticas, no pudiendo recibir tratamiento curativo y siendo subsidiarios únicamente de medidas paliativas. El manejo de estos pacientes es complejo ya que requieren una importante carga asistencial con una eficacia limitada por su corta expectativa de ...

  9. NEOPLASIA TROFOBLÁSTICA GESTACIONAL: HOSPITAL FÉLIX BULNES CERDA, 1992 - 2002

    OpenAIRE

    Aitken S,Sergio; Benavides M.,Alicia; Smirnow S,Marcia

    2004-01-01

    Objetivo: Analizar los hallazgos clínicos y el seguimiento de los casos de neoplasia trofoblástica gestacional. Material y Métodos: Se revisaron todos los casos de mola hidatidiforme en el Hospital Félix Bulnes Cerda, entre los años 1992 y 2002. Resultados: Se diagnosticaron 79 casos. La edad promedio de las pacientes fue 26,4 años. El diagnóstico de mola hidatidiforme fue sospechado clínicamente en 75,6% y en 24,4% fue hallazgo anatomopatológico. Los principales síntomas al ingreso fueron: d...

  10. Pediatric implications of multiple endocrine neoplasia.

    Science.gov (United States)

    Girvan, D P; Holliday, R L

    1987-09-01

    The association of endocrine tumors from several sites has been known for over 50 years but the familial aspects of these relationships have only been appreciated since 1954. The original term multiple familial endocrine adenomatosis (MEA) was changed to multiple endocrine neoplasia (MEN). This report describes two children aged 8 and 11 years, who are cousins with MEN IIa. A strong family history prompted investigation of these children. Pentagastrin stimulation resulted in elevated serum calcitonin levels and subsequent surgery. Unsuspected medullary thyroid carcinoma was found in each child. Proper screening of high-risk individuals should prevent this potentially lethal condition from becoming a major problem.

  11. Chemoresistant gestational trophoblastic neoplasia: a case report.

    Science.gov (United States)

    Cp, Sudha; M, Sahana

    2014-07-01

    Gestational trophoblastic neoplasia (GTN) is a disease of women in reproductive age. It is one of the most chemotherapy responsive and highly curable cancer. It is diagnosed when there is clinical, radiologic, pathologic, and/or hormonal evidence of persistent or relapsed gestational trophoblastic disease. In most instances, it is cured by surgical evacuation of the uterus. If persistent, it is treated with chemotherapy which provides response in >90% of the cases. In the unresponsive persistent cases and if the women has completed her child bearing, hysterectomy is generally recommended. Here, we report a rare case of chemoresistant GTN which was confirmed to be placental-site trophoblastic tumour (PSTT) on biopsy.

  12. New Developments in Ocular Surface Squamous Neoplasia

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    Ayşe Yağcı

    2014-09-01

    Full Text Available Ocular surface squamous neoplasia originates from conjunctiva epithelium and covers a broad spectrum of disease ranging from dysplasia to squamous cell carcinoma. Clinical features may vary from case to case. Traditional treatment of excision with no-touch technique combined with adjuvant therapies because of high recurrence rate. Main adjuvant treatments are cryotherapy and chemotherapy. In this review, clinical forms, differential diagnosis, American Joint Committee on Cancer classification and recent approaches to the management of ocular surface squamous dysplasia were described. (Turk J Ophthalmol 2014; 44: Supplement 8-14

  13. Molecular signatures of thyroid follicular neoplasia

    DEFF Research Database (Denmark)

    Borup, R.; Rossing, M.; Henao, Ricardo

    2010-01-01

    The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid...... a mechanism for cancer progression, which is why we exploited the results in order to generate a molecular classifier that could identify 95% of all carcinomas. Validation employing public domain and cross-platform data demonstrated that the signature was robust and could diagnose follicular nodules...... and robust genetic signature for the diagnosis of FA and FC. Endocrine-Related Cancer (2010) 17 691-708...

  14. Recrudescência fatal de hipertermia maligna em lactente com síndrome de Moebius. Relato de caso Recrudescencia fatal de hipertermia maligna en lactante con el síndrome de Moebius. Relato de caso Fatal recrudescence of malignant hyperthermia in an infant with Moebius syndrome

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    Cláudia Regina Fernandes

    2013-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A hipertermia maligna (HM é uma desordem farmacogenética da musculatura esquelética, caracterizada por estado hipermetabólico após anestesia com succinilcolina e/ou agentes anestésicos voláteis. Várias síndromes neuromusculares estão associadas com susceptibilidade, no entanto a síndrome de Moebius não é descrita. O dantrolene é o fármaco de escolha para o tratamento. Recrudescência pode ocorrer em até 20% dos casos após o tratamento do evento inicial. RELATO DO CASO: Lactente, masculino, primeiro gemelar, sete meses, 6,5 kg. Portador da síndrome de Moebius. Internado para correção de pé torto congênito. Apresentou HM após exposição à sevoflurano e succinilcolina, prontamente revertida com dantrolene, sendo o fármaco mantido por 24 horas. Dez horas após a interrupção do dantrolene, houve recrudescência da HM, a qual não respondeu satisfatoriamente ao tratamento, evoluindo para óbito. DISCUSSÃO: Doenças musculoesqueléticas em crianças estão associadas a aumento de risco para desenvolvimento de MH, embora a síndrome de Moebius ainda não tenha sido descrita. O dantrolene é fármaco de eleição para o tratamento da síndrome, está indicada profilaxia durante as primeiras 24-48 horas do episódio inicial. Os principais fatores associados à recrudescência são: tipo muscular, longa latência após exposição anestésica e aumento da temperatura. A criança tinha apenas um fator de risco. Este caso nos remete à reflexão de que devemos estar atentos a crianças com doença musculoesquelético e que devemos manter o tratamento durante 48 horas.JUSTIFICATIVA Y OBJETIVOS: La hipertermia maligna (HM es un trastorno farmacogenético de la musculatura esquelética, caracterizado por un estado hipermetabólico después de la anestesia con la succinilcolina y/o agentes anestésicos volátiles. Varios síndromes neuromusculares están asociados con la susceptibilidad, sin embargo el s

  15. Hubungan Kadar Laktat Dehidrogenase dengan Stadium Limfoma Maligna Non Hodgkin di Rumah Sakit Dr. M. Djamil Padang periode Desember 2009 sampai Maret 2013

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    Dian Rahma Kasir

    2014-05-01

    Full Text Available AbstrakAwal abad ke-2l masyarakat Indonesia mengalami transisi epidemiologi penyakit. Perubahan pola penyakit ini dapat dilihat dari peningkatan insiden penyakit kanker sebagai penyebab kematian di Indonesia dalam 10 tahun terakhir, yaitu dari urutan ke-12 menjadi urutan ke-6. Di Indonesia, limfoma non Hodgkin (LNH menduduki urutan keenam keganansan yang sering terjadi. Berdasarkan penelitian yang dilakukan oleh Olivia Putri Perdana di bagian patologi anatomi Fakultas Kedokteran Universitas Andalas didapatkan data bahwa pada januari 1997-desember 2001 terdapat 70 (81,39% penderita limfoma maligna non Hodgkin dari keseluruhan penderita limfoma maligna. Penelitian ini bertujuan untuk mengetahui hubungan kadar laktat dehidrogenase (LDH dengan stadium pada penderita limfoma maligna non Hodgkin. Penelitian ini adalah penelitian analitik dengan pendekatan cross sectional dengan menggunakan data yang bersumber dari rekam medik pasien. Populasi dari penelitian ini adalah data rekam medik seluruh penderita limfoma maligna non hodgkin yang berobat ke RSUP Dr. M. Djamil Padang yaitu 317 data rekam medik, tetapi yang memenuhi syarat untuk menjadi sampel hanya 40 data. Analisis statistik yang digunakan adalah uji T. Hasil uji statistik menunjukkan adanya hubungan kadar laktat dehidrogenase dengan stadium pada penderita limfoma non Hodgkin (P = 0,001. Diketahui nilai laktat dehidrogenase pada stadium III-IV lebih tinggi daripada nilai laktat dehidrogenase pada stadium I-II.Kata kunci: Laktat dehidrogenase, Limfoma maligna non Hodgkin, Stadium AbstractEarly 21th century, Indonesian society in transition epidemiology of the disease. Changing patterns of disease can be seen from the increased incidence of cancer as a cause of death in Indonesia in the last 10 years, ie from 12th to 6th order. In Indonesia, non-Hodgkin's lymphoma (NHL ranks sixt frequent in all of cancer. Based on research conducted by Olivia Putri Perdana in anatomic pathology at the Faculty of

  16. Zollinger-Ellison syndrome, acromegaly, and colorectal neoplasia

    NARCIS (Netherlands)

    Tobi, M; Cats, A; Maliakkal, BJ; Kinzie, JL; Maliakkal, R; Dullaart, RPF; Luk, GD

    Zollinger-Ellison syndrome (ZES) and acromegaly are two hypersecretory states in which colorectal neoplasia has been described, but the incidence in the former condition may not be increased. We describe four patients with colorectal neoplasia associated with the ZES and review other published

  17. Zollinger-Ellison syndrome, acromegaly, and colorectal neoplasia

    NARCIS (Netherlands)

    Tobi, M; Cats, A; Maliakkal, BJ; Kinzie, JL; Maliakkal, R; Dullaart, RPF; Luk, GD

    1997-01-01

    Zollinger-Ellison syndrome (ZES) and acromegaly are two hypersecretory states in which colorectal neoplasia has been described, but the incidence in the former condition may not be increased. We describe four patients with colorectal neoplasia associated with the ZES and review other published cases

  18. Can the Ni classification of vessels predict neoplasia?

    DEFF Research Database (Denmark)

    Mehlum, Camilla Slot; Rosenberg, Tine; Dyrvig, Anne-Kirstine

    2017-01-01

    of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. DATA SOURCES: PubMed, Embase, Cochrane, and Scopus...

  19. NEOPLASIA IN SNAKES AT ZOO ATLANTA DURING 1992-2012.

    Science.gov (United States)

    Page-Karjian, Annie; Hahne, Megan; Leach, Kate; Murphy, Hayley; Lock, Brad; Rivera, Samuel

    2017-06-01

    A retrospective study was conducted to review neoplasia of captive snakes in the Zoo Atlanta collection from 1992 to 2012. Of 255 snakes that underwent necropsy and histopathologic examination at Zoo Atlanta during the study period, 37 were observed with neoplasia at necropsy. In those 37 snakes, 42 neoplastic lesions of 18 primary cell types were diagnosed. Thirty-five of those neoplasms (83.3%) were malignant, and of those, 19 were of mesenchymal origin, whereas 14 were of epithelial origin. The median annual rate of neoplasia at necropsy was 12.5% (interquartile range = 2.8-19.5%) over the 21-yr study period. The mean estimated age at death for snakes with neoplasia was 13.2 yr (range, 1-24 yr). Investigating the incidence and clinical significance of neoplasia in captive snakes is vital for developing effective preventative and treatment regimes.

  20. Thyroid neoplasia in captive raccoons (Procyon lotor).

    Science.gov (United States)

    McCain, Stephanie L; Allender, Matthew C; Bohling, Mark; Ramsay, Edward C; Morandi, Federica; Newkirk, Kimberly M

    2010-03-01

    Two adult, spayed, female raccoons were diagnosed with thyroid neoplasia. One raccoon had a palpable, left-sided, nonfunctional thyroid adenocarcinoma which was treated with a thyroidectomy twice with local recurrence both times. After the second recurrence, pulmonary metastases were identified. A third thyroidectomy was performed, and a vascular access port was placed for administration of intravenous doxorubicin. The raccoon developed pancytopenia and became anorexic after chemotherapy, and the owner elected humane euthanasia. The second raccoon had nonpalpable, bilateral, functional follicular thyroid adenomatous hyperplasia and was treated with a right thyroidectomy and a partial left thyroidectomy, leaving behind the grossly normal portion of the left thyroid. However, the animal was still hyperthyroid after surgery and was then successfully managed with topical methimazole gel. Thyroid pathology has been documented in raccoons in Europe, but is not reported in the United States. Thyroid neoplasia in raccoons can occur as a nonfunctional adenocarcinoma, as is commonly reported in dogs, or as a functional adenoma, as is commonly reported in cats. Raccoons with adenocarcinomas should be evaluated for pulmonary metastasis. Methimazole gel may be a viable treatment option for raccoons with hyperthyroidism.

  1. Neoplasia intraepitelial cervical en mujeres menores de 25 años

    Directory of Open Access Journals (Sweden)

    Martha María Chávez Valdivia

    2012-03-01

    Full Text Available Fundamento: aunque la incidencia de lesiones preinvasivas del cervix ha sido mayor en mujeres de la tercera a cuarta década de la vida, en los últimos años se ha encontrando un número no despreciable de mujeres menores de 25 años afectadas por este tipo de lesiones de bajo o alto grado. Objetivo: describir el comportamiento de las neoplasias intraepiteliales cervicales diagnosticadas en mujeres menores de 25 años de edad, y tratadas con radiocirugía. Métodos: estudio retrospectivo y descriptivo de 67 pacientes menores de 25 años de edad, con diagnóstico de neoplasia intraepitelial cervical y tratadas por el método de radiocirugía en el Hospital General de Cienfuegos. Se analizaron las variables: edad, tipo de NIC, grado de la NIC y presencia de VPH. Resultados: el grupo más afectado fue el de las mujeres de 21 a 25 años de edad, portador del 70,4 % de lesiones. El 86, 56 % de las lesiones fue de alto grado. Las lesiones estuvieron asociadas con elevada frecuencia (88,05 % a condiloma, evidencia histológica indirecta de la citotoxicidad por la infestación tisular del VPH. Conclusiones: La presencia de NIC en mujeres menores de 25 años de edad, se configura en nuestro medio como problema de salud. El presente estudio puede servir como sustrato para desarrollar investigaciones similares en varios lugares del país, con la finalidad de aportar evidencia global que conduzca al cambio.

  2. La biopsia con aguja gruesa guiada mediante estereotaxia en el diagnóstico de las lesiones mamarias sospechosas de malignidad

    OpenAIRE

    Hidalgo Pérez, José Alberto

    2000-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada El cáncer de mama es una enfermedad en la que no es posible la prevención primaria por lo que para disminuir la morbimortalidad es imprescindible un diagnóstico precoz que permita un tratamiento efectivo. Dado que en las campañas de cribado y en las mamografías de control se diagnostican muchas lesiones de las que no es posible saber si se trata o no de lesiones malignas hasta que no se biopsian, son necesarias técnicas ...

  3. Magnetic resonance imaging in the evaluation of standard radiotherapy field borders in patients with uterine cervix cancer;Ressonancia magnetica para avaliacao dos limites dos campos classicos de radioterapia em pacientes portadoras de neoplasia maligna de colo uterino

    Energy Technology Data Exchange (ETDEWEB)

    Freire, Geison Moreira; Dias, Rodrigo Souza; Giordani, Adelmo Jose; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo, E-mail: segreto.dmed@epm.b [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Unit of Radioterapy; Ribalta, Julisa Chamorro Lascasas [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Dept. de Gynecology

    2010-05-15

    Objective: to evaluate, by means of magnetic resonance imaging, the standardized field borders in radiotherapy for malignant neoplasm of uterine cervix, and to determine the role of this method in the reduction of possible planning errors related to the conventional technique. Materials and methods: magnetic resonance imaging studies for planning of treatment of 51 patients with uterine cervix cancer were retrospectively analyzed. The parameters assessed were the anterior and posterior field borders on sagittal section. Results: The anterior field border was inappropriate in 20 (39.2%) patients and geographic miss was observed in 37.3% of cases in the posterior border. The inappropriateness of both field borders did not correlate with clinical parameters such as patients' age, tumor staging, histological type and degree. Conclusion: the evaluation of standardized field borders with the use of magnetic resonance imaging has demonstrated high indices of inappropriateness of the lateral field borders, as well as the relevant role of magnetic resonance imaging in the radiotherapy planning for patients with uterine cervix cancer with a view to reduce the occurrence of geographic miss of the target volume. (author)

  4. Evolução da mortalidade por neoplasias malignas no Rio Grande do Sul, 1979-1995 Time trends in cancer mortality in Rio Grande do Sul, Brazil, 1979-1995

    Directory of Open Access Journals (Sweden)

    Ana Luiza Curi Hallal

    2001-11-01

    Full Text Available Foi analisada a mortalidade por câncer no Rio Grande do Sul (RS, entre 1979 e 1995. As variáveis consideradas foram sexo, idade, ano de ocorrência do óbito e causa básica da morte. Para análise da tendência das taxas padronizadas de mortalidade (método direto, população padrão: RS-1996 foi utilizada a regressão linear simples. As localizações mais freqüentes do tumor foram: pulmão, esôfago, próstata, estômago e cólon/reto, nos homens, e mama, colo do útero/útero não especificado, pulmão, cólon/reto e estômago, nas mulheres. A tendência temporal das taxas padronizadas de mortalidade, em cada sexo, do ponto de vista estatístico, foi de estabilidade, bem como por câncer de cólon/reto feminino e de colo do útero/útero não especificado. Verificou-se tendência estatisticamente significativa de crescimento da mortalidade por câncer de pulmão, em ambos os sexos, mama feminina, próstata e cólon/reto masculino; e, da mesma forma, decréscimo por câncer de estômago, para ambos os sexos, e esôfago, para os homens.The aim of this study was to analyze cancer mortality in Rio Grande do Sul (RS, Brazil, during the period from1979 to 1995. Study variables were sex, age, year and underlying cause of death. The simple linear regression technique was used to evaluate the trend of standardized death rates (direct method, using the population of RS in 1996 as the standard. The most frequent sites of tumors in males were lung, esophagus, prostate, stomach and colon/rectum; in females they were breast, cervix of the uterus, lung, colon/rectum and stomach. Standardized death rates presented a stable trend for all malignant neoplasms in both sexes, as did cancer of cervix of the uterus/ non-specified uterus and colon/rectum tumors in females. A significant rising trend was observed in mortality rates due to lung cancer in both sexes, breast cancer in females, prostate and colon/rectum cancer in males. The rates of stomach cancer presented a significant decreasing trend in both sexes as did esophagus cancer rates in men.

  5. Photodynamic therapy of cervical intraepithelial neoplasia

    Science.gov (United States)

    Inada, Natalia M.; Lombardi, Welington; Leite, Marieli F. M.; Trujillo, Jose R.; Kurachi, Cristina; Bagnato, Vanderlei S.

    2014-03-01

    Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors, especially in Gynecology. The photodynamic reaction is based on the production of reactive oxygen species after the activation of a photosensitizer. Advantages of the PDT in comparison to the surgical resection are: ambulatory treatment and tissue recovery highly satisfactory, through a non-invasive procedure. The cervical intraepithelial neoplasia (CIN) grades I and II presents potential indications for PDT. The aim of the proposed study is to evaluate the safety and efficacy of the PDT for the diagnostics and treatment of CIN I and II. The equipment and the photosensitizer are produced in Brazil with a representative low cost. It is possible to visualize the fluorescence of the cervix and to treat the lesions, without side effects. The proposed clinical protocol shows great potential to become a public health technique.

  6. The Danish National Chronic Myeloid Neoplasia Registry

    DEFF Research Database (Denmark)

    Bak, Marie; Ibfelt, Else Helene; Stauffer Larsen, Thomas;

    2016-01-01

    AIM: The Danish National Chronic Myeloid Neoplasia Registry (DCMR) is a population-based clinical quality database, introduced to evaluate diagnosis and treatment of patients with chronic myeloid malignancies. The aim is to monitor the clinical quality at the national, regional, and hospital...... of follow-up. The forms include variables that describe clinical/paraclinical assessments, treatment, disease progression, and survival - disease-specific variables - as well as variables that are identical for all chronic myeloid malignancies. DESCRIPTIVE DATA: By the end of 2014, the DCMR contained data...... on 2,690 patients with an inclusion rate of ∼500 patients each year. Since the registry was established, annual reports have shown consistently high national coverage and data completeness, ≥90% and ≥88%, respectively. CONCLUSION: The DCMR is a national database used for monitoring the quality...

  7. Neoplasia endocrina múltiple tipo-2b

    OpenAIRE

    Lastra, Guido; de Franco, Roberto; Rueda P., Pedro Nel; Pradilla S., Lina P.; Paz C., Óscar

    2014-01-01

    La neoplasia endocrina multiple tipo 2 comprendetres sindromes : la neoplasia endocrina múltiple2A con predisposición genética para desarrollarcarcinoma medular del tiroides,feocromocitoma e hiperplasia primaria deparatiroides. La neoplasia endocrina múltiple 2B,desorden autosómico dominante con feocromocitomay carcinoma medular del tiroides quegeneralmente se presenta a una edad más tempranay es más agresivo que la de tipo 2A, porlo que su diagnóstico precoz es crítico; estospacientes, que t...

  8. Actualización del diagnóstico y tratamiento de la neoplasia intraepitelial vulvar.

    Directory of Open Access Journals (Sweden)

    Rafael E. Pérez Castro

    2011-09-01

    Full Text Available La Neoplasia Intraepitelial Vulvar (NIV constituye lesiones potencialmente premalignas del epitelio escamoso de la vulva con diversos grados de diferenciación celular y maduración. En el aspecto histológico son hiperplasia de las células basales y parabasales, además tienen características genéticas morfológicas y metabólicas similares a las células cancerosas. Son etapas previas a la enfermedad. Generalmente las NIV se diagnostican como lesiones de alto grado (NIV I, II y III o carcinoma in situ. Alrededor del 5% progresan a la malignidad. Técnicamente puede ser un diagnóstico fácil, pero en la práctica no resulta así, siendo la vulvoscopia la principal arma para su diagnóstico. Estudios realizados en los últimos años señalan que aumenta cada vez más en mujeres más jóvenes, en pacientes con infección por HPV, en pacientes con neoplasia cervical intraepitelial o en cáncer en otras localizaciones del extracto genital inferior. Para tomar una decisión terapéutica hay que tener en cuenta: la edad de la paciente, la localización de las lesiones (áreas pilosas y no pilosas o descartar siempre un cáncer invasor y no invasor. Los tratamientos de lección pueden ser, extirpación local, vulvahectomía cutania parcial o total, destrucción con crioterapia o láser y técnicas combinadas de escisión o ablación. La conducta expectante valorando algunas características es la tendencia actual.

  9. Papel da criocirurgia no tratamento das neoplasias cutâneas do segmento cabeça e pescoço: análise de 1900 casos

    Directory of Open Access Journals (Sweden)

    Antonio Azoubel Antunes

    Full Text Available OBJETIVO: Demonstrar a experiência dos autores na utilização da criocirurgia como tratamento de lesões benignas e malignas da pele e mucosa no segmento cabeça e pescoço. MÉTODO: Os autores realizam um estudo retrospectivo multicêntrico de 1900 casos de pacientes portadores de neoplasias benignas e malignas da cabeça e do pescoço, atendidos e tratados no Centro de Oncologia do Hospital Universitário Oswaldo Cruz (CEON/HUOC/UPE, Hospital de Câncer de Pernambuco (HCP e clínica privada, no período de abril de 1977 a abril de 2002 (25 anos. Comparam, ainda, os dados obtidos com a revisão bibliográfica realizada, bem como sua experiência pessoal na utilização de tal modalidade terapêutica. RESULTADOS: Do total de pacientes, 57,9% eram do sexo masculino e a quinta e sexta décadas de vida foram as mais frequentemente acometidas (58,9%. O Carcinoma basocelular foi o tipo histológico predominante (63,1% - 1200 casos, seguido dos hemangiomas (14,2% - 270 casos. O tempo médio de exposição das lesões ao nitrogênio líquido foi de 15 e 35 segundos, e o tempo médio de cicatrização de 14 e 21 dias para as lesões benignas e malignas respectivamente. CONCLUSÕES: A indicação da criocirurgia deve obedecer alguns critérios de avaliação como o aspecto macroscópico e tamanho da lesão, tipo histológico, localização, idade e perfil social de cada paciente. Quando indicada e executada corretamente, oferece idênticos índices de cura aos outros métodos terapêuticos convencionais.

  10. Prevalencia de neoplasias en caninos en la universidad de los Llanos, durante 2004 a 2007

    Directory of Open Access Journals (Sweden)

    Pablo Cruz-Casallas

    2010-04-01

    Full Text Available Objetivo. Describir y clasificar las enfermedades neoplásicas diagnosticadas en el laboratorio de Patología Veterinaria de la Universidad de los Llanos, desde enero de 2004 hasta junio de 2007. Materiales y métodos. Como fuente de información se utilizó la base de datos de las historias clínicas y de los exámenes de necropsia de la Clínica Veterinaria de la Universidad de los Llanos. Las muestras analizadas procedieron de especímenes obtenidos por biopsias y de tumores hallados durante necropsia. Se analizaron 322 casos clínicos, de los cuales 113 correspondieron a enfermedades neoplásicas (35%. Resultados. En general, la especie más afectada fue la canina (93 de 113 casos, siendo las razas mestizas las más afectadas (p0.05. Conclusiones. Los tumores de piel fueron los de mayor incidencia, quizá por la mayor facilidad de diagnóstico durante la consulta clínica, comparados con otras neoplasias que afectan órganos y tejidos más profundos.

  11. Inmunología tumoral y neoplasias del sistema inmune

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco de la Calle, Francisco Manuel; Vázquez Araujo, Begoña

    2012-01-01

    Inmunología tumoral: vigilancia inmunológica, antígenos tumorales, respuesta inmune antitumoral, escape tumoral. Inmunología y diagnóstico. Inmunoterapia. Neoplasias del sistema inmune: leucemias y linfomas.

  12. Inmunología tumoral y neoplasias del sistema inmune

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco de la Calle, Francisco Manuel; Vázquez Araujo, Begoña

    2012-01-01

    Inmunología tumoral: vigilancia inmunológica, antígenos tumorales, respuesta inmune antitumoral, escape tumoral. Inmunología y diagnóstico. Inmunoterapia. Neoplasias del sistema inmune: leucemias y linfomas.

  13. Molecular biological factors in the diagnosis of cervical intraepithelial neoplasias

    Directory of Open Access Journals (Sweden)

    Yu. N. Ponomareva

    2010-01-01

    Full Text Available The authors have made a complex analysis of the molecular biological factors associated with cervical intraepithelial neoplasia. They have revealed that infection by oncogenic human papillomavirus types is associated with suppressed apoptosis and enhanced cellular proliferative activity, which can be effectively used in the diagnosis and prediction of cervical neoplasias to optimize management tac- tics and to improve the results of treatment.

  14. Ultrasonography is an accurate technique for the diagnosis of gastrointestinal tumors in patients without localizing symptoms La ecografía es una técnica sensible en el diagnóstico de las neoplasias gastrointestinales en pacientes sin síntomas localizadores

    Directory of Open Access Journals (Sweden)

    D. Martínez-Ares

    2009-11-01

    Full Text Available Introduction and objectives: this study compared the accuracy of ultrasonography in the diagnosis of gastrointestinal tumors in patients with several degrees of clinical suspicion. Material and methods: we recruited patients that were suspect for gastrointestinal neoplasia but with no evidence of localizing symptoms (group A, and patients that were suspect for colon cancer (group B or for gastric cancer (group C. Accuracy in the diagnosis was compared for: gastric cancer in groups A and C, and for colon cancer in groups A and B. The comparison was made by using the contingency coefficient, which quantifies coincidence of endoscopic and ultrasonographic diagnoses. Results: seventy-nine patients were included in group A (48 males, wherein 12 colon and 5 gastric neoplasms were detected. Group B was comprised of 153 patients (78 males and included 66 patients with colorectal cancer (CCR. Group C contained 58 patients (35 males, 31 of whom were diagnosed with gastric cancer. The accuracy of sonography for diagnosing colon cancer was 95.5% for group A and 87.5% for group B. The contingency coefficient for endoscopy vs. ultrasonography was greater for group A: 0.658 than for group B: 0.549. The diagnostic accuracy for gastric cancer was 97.4% for group A and 86.2% for group C. The contingency coefficient between endoscopic and ultrasonographic diagnoses was also greater in group A (0.618 than in group C (0.588. Conclusions: the accuracy of ultrasonography in diagnosing colon and gastric cancer is not lower in patients without localizing symptoms.Introducción y objetivos: en todos los estudios publicados hasta la fecha se ha evaluado la precisión de la ecografía en el diagnóstico del cáncer de colon y del cáncer gástrico en pacientes en los que esta era la sospecha diagnóstica o ya con un diagnóstico establecido de esta patología. Nosotros, en este estudio, comparamos la sensibilidad de la ecografía en pacientes con diferentes grados de

  15. Rabdomiólise induzida por exercício e risco de hipertermia maligna: relato de caso Rabdomiólisis inducida por ejercicio y riesgo de hipertermia maligna: relato de caso Exercise-induced rhabdomyolysis and risk for malignant hyperthermia: case report

    Directory of Open Access Journals (Sweden)

    Ricardo Barreira Uchoa

    2003-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Rabdomiólise é a lesão do músculo esquelético com liberação dos constituintes da célula para o plasma. Exercício exaustivo e extenuante, especialmente em homens não condicionados, pode resultar em morbidade maior com hiperpotassemia, acidose metabólica, coagulação intravascular disseminada, síndrome do desconforto respiratório agudo e rabdomiólise. Tem sido sugerido que hipertermia maligna, choque térmico e rabdomiólise induzida por exercício são síndromes fortemente relacionadas. O objetivo deste relato é descrever um caso de rabdomiólise fulminante após exercício físico e a correlação do quadro com hipertermia maligna. RELATO DO CASO: Homem de 32 anos apresentou mal estar seguido de síncope após correr 2.350 m em prova de aptidão física. Foi levado ao hospital, evoluiu com insuficiência respiratória, bradiarritmia, hipotensão arterial e parada cardiocirculatória. Foi reanimado, ficou comatoso, com importante rigidez muscular, choque persistente, distúrbio de coagulação, acidose metabólica, hiperpotassemia, evoluindo para óbito em menos de 24 horas. A autópsia revelou edema agudo de pulmão, coagulação intravascular disseminada e insuficiência renal aguda conseqüente a rabdomiólise. CONCLUSÕES: Tem sido sugerido que rabdomiólise induzida por exercício e hipertermia maligna são síndromes fortemente relacionadas. O paciente evoluiu para óbito antes de qualquer investigação específica para hipertermia maligna. No entanto, é importante pesquisar a susceptibilidade para esta síndrome em seus familiares a fim de evitar eventos anestésicos com potencial risco para a vidaJUSTIFICATIVA Y OBJETIVOS: Rabdomiólisis es la lesión del músculo esquelético con liberación de los constituyentes de la célula para el plasma. Ejercicio exhaustivo y extenuante, especialmente en hombres no condicionados, puede resultar en morbidad mayor con hiperpotasemia, acidosis metab

  16. Vulvar and Vaginal Cancer, Vulvar Intraepithelial Neoplasia 3 and Vaginal Intraepithelial Neoplasia 3: Experience of a Referral Institute

    National Research Council Canada - National Science Library

    Siegler, Efraim; Segev, Yakir; Mackuli, Lena; Auslender, Ron; Shiner, Mayan; Lavie, Ofer

    2016-01-01

    ...: human papillomavirus (HPV) induced or non-HPV induced. To evaluate the demographic and clinical characteristics associated with vulvar or vaginal cancer and vulvar and vaginal intraepithelial neoplasia 3 (VIN3, VAIN3...

  17. Genetics of Multiple Endocrine Neoplasia Type 1/Multiple Endocrine Neoplasia Type 2 Syndromes.

    Science.gov (United States)

    Hyde, Samuel M; Cote, Gilbert J; Grubbs, Elizabeth G

    2017-06-01

    Multiple endocrine neoplasia syndromes types 1 and 2 represent well-characterized yet clinically heterogeneous hereditary conditions for which diagnostic and management recommendations exist; genetic testing for these inherited endocrinopathies is included in these guidelines and is an important part of identifying affected patients and their family members. Understanding of these mature syndromes is challenged as more individuals undergo genetic testing and genetic data are amassed, with the potential to create clinical conundrums that may have an impact on individualized approaches to management and counseling. Clinicians who diagnose and treat patients with MEN syndromes should be aware of these possibilities. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. NEOPLASIAS TESTICULARES EN CANINOS: UN CASO DE TUMOR DE CÉLULAS DE SERTOLI

    Directory of Open Access Journals (Sweden)

    Pedro Eslava M

    2008-04-01

    Full Text Available Las neoplasias del testículo no son muy frecuentes en los animales domésticos Los caninos son los que las manifiestan con mayor frecuencia; estando entre los 0.7 y 4.6% de todos los tumores que sufren. Algunos factores se han asociado como predisponentes: entre ellos la edad madura y la presencia del criptorquidia uni o principalmente bilateral. Las neoplasias del testículo más frecuente son el tumor de células de Sertoli, el tumor de células de Leydig y los seminomas, que en general presentan la conducta benigna. El tratamiento recomendado previa evaluación clínica, es la orquiectomía (uni o bilateral, incluidos en los casos de criptorquidismo el testículo alojado en el escroto. En el presente manuscrito se realiza una revisión del tema en su primera parte; en la segunda, se describe el caso de un tumor de células del Sertoli en un canino Cocker que presentó al examen clínico un testículo retenido y síndrome feminizante. En este se caso se efectuó el diagnóstico histopatológico después de la extracción quirúrgica de la masa abdominal y también se realizó la extirpación del testículo alojado en el escroto.

  19. Anal intraepitelial neoplasia: a narrative review

    Directory of Open Access Journals (Sweden)

    Garazi Elorza

    2016-01-01

    Full Text Available Anal intraepitelial neoplasia (AIN constitutes a major health problem in certain risk groups, such as patients with immunosuppression of varied origin, males who have sexual relations with other males, and females with a previous history of vaginal or cervical abnormalities in cytology. Its relationship with the human papillomavirus (HPV infection has been well documented; however, many of the factors involved in the progression and regression of the viral infection to dysplasia and anal carcinoma are unknown. AIN can be diagnosed through cytology of the anal canal or biopsy guided by high-resolution anoscopy. However, the need for these techniques in high-risk groups remains controversial. Treatment depends on the risk factors and given the high morbidity and high recurrence rates the utility of the different local treatments is still a subject of debate. Surgical biopsy is justified only in the case of progression suggesting lesions. The role of the vaccination in high-risk patients as primary prevention has been debated by different groups. However, there is no general consensus on its use or on the need for screening this population.

  20. Anal cancer and intraepithelial neoplasia screening: Areview

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    This review focuses on the early diagnosis of anal cancer and its precursor lesions through routine screening. Anumber of risk-stratification strategies as well as screeningtechniques have been suggested, and currently littleconsensus exists among national societies. Much ofthe current clinical rationale for the prevention of analcancer derives from the similar tumor biology of cervicalcancer and the successful use of routine screening toidentify cervical cancer and its precursors early in thedisease process. It is thought that such a strategy ofidentifying early anal intraepithelial neoplasia will reducethe incidence of invasive anal cancer. The low prevalenceof anal cancer in the general population prevents theuse of routine screening. However, routine screeningof selected populations has been shown to be a morepromising strategy. Potential screening modalities includedigital anorectal exam, anal Papanicolaou testing, humanpapilloma virus co-testing, and high-resolution anoscopy.Additional research associating high-grade dysplasiatreatment with anal cancer prevention as well as directcomparisons of screening regimens is necessary todevelop further anal cancer screening recommendations.

  1. Histologic classification of penile intraepithelial neoplasia.

    Science.gov (United States)

    Velazquez, Elsa F; Chaux, Alcides; Cubilla, Antonio L

    2012-05-01

    Penile squamous cell carcinomas (SCCs) and their corresponding precancerous lesions can be classified in 2 major groups: human papillomavirus (HPV) related and HPV unrelated. In the former (warty and basaloid SCC), there is a predominance of undifferentiated basaloid cells. In the latter (eg, usual, papillary, and verrucous SCC), the predominant cell is larger with abundant eosinophilic cytoplasm. Based on these morphologic features, a new term, "penile intraepithelial neoplasia" (PeIN), was proposed. PeIN was further subclassified into differentiated and undifferentiated, with the latter being subdivided into basaloid, warty, and warty-basaloid subtypes. Macroscopically, PeIN subtypes are indistinguishable. Microscopically, differentiated PeIN is characterized by acanthosis, parakeratosis, enlarged keratinocytes with abundant "pink" cytoplasm (abnormal maturation), and hyperchromatic cells in the basal layer. In basaloid PeIN the epithelium is replaced by a monotonous population of uniform, small, round, and basophilic cells. Warty PeIN is characterized by a spiky surface, prominent atypical parakeratosis, and pleomorphic koilocytosis. Warty-basaloid PeIN show features of both warty and basaloid PeIN. There is a significant association of subtypes of PeIN with specific variants of invasive SCCs. This is a simple and reproducible nomenclature for penile precancerous lesions based on cell type and differentiation. It takes into account the similarities between vulvar and penile pathology and the hypothesis of a bimodal pathway of penile cancer progression.

  2. Las Afecciones Prostáticas y su Tratamiento

    Directory of Open Access Journals (Sweden)

    Jorge Cavelier Gaviria

    1993-12-01

    Full Text Available

    En la actualidad se sabe que el cáncer de la próstata se presenta aproximadamente en el 25% de todos los hombres mayores de 50 años, lo cual significa que esta neoplasia es aún más frecuente que el cáncer del pulmón o del colon. Este aumento y su hallazgo se deben a una mejor metodología para diagnosticar y reportar los casos, lo cual a su vez permite a los hombres vivir hasta una edad más avanzada.

    Debido a esto, se recomienda en la actualidad las evaluaciones anuales en todos los hombres mayores de 50 años. Sin embargo, como este cáncer ocurre con más frecuencia en hombres jóvenes de la raza negra, se recomienda que éstos se sometan a una temprana evaluación tan pronto han cumplido los 40 años. Igualmente quienes tienen una historia clínica de cáncer de la próstata en la familia también deben hacerse los debidos controles desde los 40 años.

    El cáncer de la próstata a menudo se desarrolla sin que haya síntomas que lo delaten hasta que ya está bastante avanzado. Hasta hace poco, los médicos confiaban en el tacto rectal para detectarlo, pero hoy sabemos que esta prueba no basta ya que la totalidad de la próstata no puede ser examinada exactamente. Aunque las áreas de tejido denso y endurecido suelen revelar la existencia de un tumor, también hay protuberancias anormales que se desarrollan sin que haya cambios en la textura de los tejidos y por ser blandas pueden escapar así al tacto rectal.

    Hace tres años comenzó a utilizarse un sencillo análísis de la sangre, el de los antígenos específicos de la próstata. Este análisis mide los niveles de la proteína o enzima prostática que producen tanto las células sanas como las cancerosas. Las células malignas, por naturaleza, se reproducen rápidamente de modo que producen mayores cantidades de antígenos específicos de la próstata, elevando los niveles citados más allá del máximo que se considera normal.

    Sin embargo, en los hombres

  3. Neoplasias primárias múltiplas em pacientes com câncer colorretal Multiple primary neoplasms in colorectal cancer patients

    Directory of Open Access Journals (Sweden)

    Marcelo de Souza CURY

    2000-04-01

    Full Text Available Introdução - A presença de uma segunda neoplasia maligna, tendo sítio e histologia diferentes da primeira, define o conceito de neoplasias primárias múltiplas. Com o aumento da sobrevida dos pacientes com câncer, houve um aumento de neoplasias primárias múltiplas. Este estudo objetiva avaliar a freqüência de neoplasias primarias múltiplas em pacientes com diagnóstico de câncer colorretal do Setor de Oncologia da Disciplina de Gastroenterologia da Universidade Federal de São Paulo. Pacientes e Métodos - No período de 1993 a 1998, 145 pacientes com câncer colorretal foram acompanhados no Setor de Oncologia da Disciplina de Gastroenterologia da Universidade Federal de São Paulo. Destes, cinco pacientes (3,4% tinham neoplasias primárias múltiplas. O segundo tumor foi confirmado por exame histológico, sendo excluídas as possibilidades de metástase. Resultados - A idade média dos doentes com neoplasias primárias múltiplas foi de 60,6 anos, quatro eram do sexo feminino e um do masculino, três apresentaram doença no reto, um no cólon direito e um no cólon esquerdo. Os outros sítios foram mama, útero, útero e vagina, pele e lábio. Um paciente foi a óbito e os outros estão em acompanhamento, sendo que dois, há mais de três anos. Dois pacientes tinham sido submetidos a radioterapia pélvica antes do aparecimento da neoplasia colorretal. Em um paciente o tumor colorretal antecedeu o outro câncer e em quatro apareceu posteriormente ao diagnóstico da outra neoplasia primária. Discussão - A prevalência de neoplasias primárias múltiplas foi de 3,4%, sendo maior no sexo feminino. Câncer de endométrio foi o outro tumor maligno mais freqüente. Quarenta por cento dos nossos pacientes foram submetidos a radioterapia. Acreditamos ser importante o acompanhamento dos pacientes para o diagnóstico precoce de uma nova neoplasia em qualquer paciente que já tenha apresentado um câncer.Introduction - Multiple primary

  4. Cutaneous manifestations of internal malignancies in a tertiary health care hospital of a developing country Manifestações cutâneas de doenças malignas em um hospital terciário de um país em desenvolvimento

    Directory of Open Access Journals (Sweden)

    Alex G Ortega-Loayza

    2010-10-01

    diagnosticada antes (45,8% ou no momento (38,5% do diagnóstico do tumor subjacente. Os tumores malignos mais frequentes foram linfoma, adenocarcinomas do trato digestivo superior e neoplasias malignas do pâncreas. A idade média dos pacientes foi de 47.0 ± 16.9 anos e a duração da doença desde o diagnóstico foi de 13,7 meses. A taxa de mortalidade foi de 75%. Dermatoses paraneoplásicas são condições dermatológicas raras de difícil diagnóstico. O controle também é prejudicado quando pacientes não têm acesso fácil à centros de saúde por questões financeiras ou geográficas. No entanto, quando identificadas, elas podem facilitar o diagnóstico precoce de um tumor associado e contribuir para um aumento do controle dos pacientes.

  5. [Heredity in renal and prostatic neoplasia].

    Science.gov (United States)

    Prayer Galetti, T; D'Arrigo, L; De Zorzi, L; Patarnello, T

    1997-09-01

    There is an ever growing report of data supporting the evidence that accumulated genetic changes underlie the development of neoplasia. The paradigma of this multistep process is colon cancer were cancer onset is associated, over decades, with at least seven genetic events. The number of genetic alterations increases moving from adenomatous lesions to colon cancer and, although the genetic alterations occur according to a preferred sequence, the total accumulation of changes rather than their sequential order is responsible of tumor biological behavior. It is noteworthy that, at least for this neoplasia, carcinogenesis appears to arise as a result of the mutational activation of oncogenes coupled with the mutational inactivation of tumor suppressor genes. In some cases mutant suppressor genes appear to exert a phenotypic effect even when present in the heterozygous state thus been non "recessive" at the cellular level. The general features of this model may apply also to renal cell cancer (RCC) and prostate cancer (CaP). Extensive literature exists on the cytogenetic and molecular findings in RCC. Only 2% of RCC are familiar, but molecular genetic studies of these cancers have provided important informations on RCC pathogenesis. As with other cancers, familiar RCC is characterized by an early age of onset and frequent multicentricity. A pathological classification useful in studying these patients subdivide renal cancers in papillary (pRCC) and non papillary (RCC) neoplasms. The most common cause of inherited RCC is the Von Hippel Lindau disease (VHL) a dominantly inherited multisystem disorder characterized by retinal and cerebellar hemangioblastomas, pheochromocytomas, pancreatic cysts and RCC. Over 70% of these patients will develop an RCC by their sixth decade. In 1993 the isolation of the tumor suppressor gene in VHL disease at the level of chromosome 3p25-p26 have lead to a better understanding of RCC. Most missense mutations are associated with high risk of

  6. Telomerase activity in cervical intraepithelial neoplasia

    Institute of Scientific and Technical Information of China (English)

    王淑珍; 孙建衡; 张伟; 金顺钱; 王洪平; 金玉生; 曲萍; 刘毅; 李茉

    2004-01-01

    Background It was reported that telomerase expression is closely associated with cellular immortality and cancer. This study was designed to investigate the relationship between telomerase expression and the carcinogenesis of cervical cancer, the possible use of telomerase as a marker of cervical intraepithelial neoplasia (CIN) progression or regression, and the natural history of CIN. Methods Telomeric repeat amplification protocol (TRAP) assay was used to measure telomerase activity in cervical scrapings and biopsy samples obtained from 105 cases affected with various cervical conditions, including chronic cervicitis (n=20), CIN (n=64, 16 cases of CIN Ⅰ , 20 cases of CIN Ⅱ, and 28 cases of CIN Ⅲ ), and invasive squamous cell carcinoma (n =21 ).Results In exfoliated cell samples, telomerase activity was detected in 5 of 20 (25. 0% ) cases of cervicitis, 10 of 16 (62.5%) cases of CIN Ⅰ , 11 of 20 (55.0%) cases of CIN Ⅱ, 23 of 28 (82.1%) cases of CIN Ⅲ, and 13 of 21 (61.9%) cases of carcinoma. In cervical biopsy samples, telomerase activity was detected in 6 of 20 (30. 0%) cases of cervicitis, 8 of 16 (50. 0%) cases of CIN Ⅰ , 9 of 20 (45.0%) cases of (CIN Ⅱ, 27 of 28 (96. 4%) cases of CIN Ⅲ, and 20 of 21 (95. 2%) cases of carcinoma. Telomerase activation was significantly higher in CIN samples than in cervicitis samples. Telomerase activity was detected at similar frequency in samples from cervical scrapings and cervical biopsies.Conclusion These results seem to suggest that telomerase expression may be associated with carcinogenesis of the cervix. TRAP assay of cervical scraping samples could be used to monitor and predict the development of CIN in clinical practice.

  7. Radiogenic neoplasia in thyroid and mammary clonogens

    Energy Technology Data Exchange (ETDEWEB)

    Clifton, K.H.

    1992-05-20

    We have developed rat thyroid and mammary clonogen transplantation systems for the study of radiogenic cancer induction at the target cell level in vivo. The epithelial cell populations of both glands contain small subpopulations of cells which are capable of giving rise to monoclonal glandular structures when transplanted and stimulated with appropriate hormones. Previous results indicated that these clonogens are the precursor cells of radiogenic cancer, and that initiation, is common event at the clonegenic cell level. Detailed information on the physiologic control of clonogen proliferation, differentiation, and total numbers is thus essential to an understanding of the carcinogenic process. We report here studies on investigations on the relationships between grafted thyroid cell number and the rapidity and degree of reestablishment of the thyroid-hypothalamus-pituitary feedback axis in thyroidectomized rats maintained on a normal diet or an iodine deficient diet; studies of the persistence of, and the differentiation potential and functional characteristics of, the TSH-(thyrotropin-) responsive sub- population of clonogens during goitrogenesis, the plateau-phase of goiter growth, and goiter involution; studies of changes in the size of the clonogen sub-population during goitrogenesis, goiter involution and the response to goitrogen rechallenge; and a large carcinogenesis experiment on the nature of the grafted thyroid cell number-dependent suppression of promotion/progression to neoplasia in grafts of radiation-initiated thyroid cells. Data from these studies will be used in the design of future carcinogenesis experiments on neoplastic initiation by high and low LET radiations and on cell interactions during the neoplastic process.

  8. Radiogenic neoplasia in thyroid and mammary clonogens

    Energy Technology Data Exchange (ETDEWEB)

    Clifton, K.H.

    1991-05-31

    We have developed rat thyroid and mammary clonogen transplantation systems for the study of radiogenic cancer induction at the target cell level in vivo. The epithelial cell populations of both glands contain small subpopulations of cells which are capable of giving rise to monoclonal glandular structures when transplanted and stimulated with appropriate hormones. During the end of the last grant year and the first half of the current grant year, we have completed analyses and summarized for publication: investigations on the relationship between grafted thyroid cell number and the rapidity and degree of reestablishment of the thyroid-hypothalamicpituitary axis in thyroidectomized rats maintained on a normal diet or an iodine deficient diet; studies of the persistence of, and the differentiation potential and functional characteristics of, the TSH- (thyrotropin-) responsive sub-population of clonogens during goitrogenesis, the plateau-phase of goiter growth, and goiter involution; studies of changes in the size of the clonogen sub-population during goitrogenesis, goiter involution and the response to goitrogen rechallenge; and the results of the large carcinogenesis experiment on the nature of the grafted thyroid cell number-dependent suppression of promotion/progression to neoplasia in grafts of radiation-initiated thyroid cells. We are testing new techniques for the culture, cytofluorescent analysis and characterization mammary epithelial cells and of clonogens in a parallel project, and plan to apply similar technology to the thyroid epithelial cells and clonogen population. Data from these studies will be used in the design of future carcinogenesis experiments on neoplastic initiation by high and low LET radiations and on cells interactions during the neoplastic process.

  9. DCLK1 immunoreactivity in colorectal neoplasia

    Directory of Open Access Journals (Sweden)

    Bellows CF

    2012-04-01

    Full Text Available Giuseppe Gagliardi1, Monica Goswami1, Roberto Passera2, Charles F Bellows11Department of Surgery and Pathology, Tulane University, New Orleans, LA, USA; 2Division of Nuclear Medicine Azienda Ospedaliero-Universitaria San Giovanni Battista, Turin, ItalyIntroduction: Microtubule-associated doublecortin and CaM kinase-like-1 (DCLK1 is a novel candidate marker for intestinal stem cells. The aim of our study was to assess DCLK1 immunoreactivity in colorectal carcinogenesis and its correlation with prognosis.Methods: DCLK1 immunostaining was performed in colorectal tissue from 71 patients, including 18 adenomatous polyps, 40 primary adenocarcinomas, and 14 metastatic lesions. Each case was evaluated by a combined scoring method based on the intensity of staining (score 0–3 and the percentage of tissue staining positive (score 0–3. Immunoexpression for DCLK1 was considered as positive when the combined score was 2–6 and negative with a score of 0–1.Results: Overall, 14/18 (78% of polyps, 30/40 (75% of primary adenocarcinomas, and 7/14 (50% of distant metastases were positive for DCLK1. In adenomatous polyps and primary cancer there was no association between DCLK1 staining score and tumor pathology. However, after curative colorectal cancer resection, patients whose tumor had a high (≥5 combined staining score had increased cancer-specific mortality compared to patients with low (0–4 staining score (hazard ratio 5.89; 95% confidence interval: 1.22–28.47; P = 0.027.Conclusion: We found that DCLK1 is frequently expressed in colorectal neoplasia and may be associated with poor prognosis. Further studies are necessary to validate the use of DCLK1 as a prognostic marker.Keywords: DCLK1, DCAMKL-1, gastrointestinal stem cell, cancer stem cell, adenomatous polyps, liver metastasis, immunohistochemistry

  10. ¿Es razonable el abordaje laparoscópico en patología maligna colo-rectal?

    OpenAIRE

    Hernandez-Lizoain, J.L. (Jose Luis); Diez-Caballero, A. (Alberto); J. Baixauli; F. Martinez; F. Pardo; Cienfuegos, J.A. (Javier A.)

    1999-01-01

    Desde que se efectuó la primera resección de colon por vía laparoscópica en 1990, han sido publicados numerosos artículos, manifestándose diferentes opiniones, algunas de ellas francamente contrapuestas, en cuanto a validez o no de esta vía de abordaje quirúrgico, para el tratamiento del cáncer colo-rectal. El presente estudio de revisión pretende poner en claro cuál es la situación actual de la resección de colon por vía laparoscópica. Se analizan las ventajas e inconvenientes de dicho tr...

  11. Surgical intervention in children with multiple endocrine neoplasia type 2.

    Science.gov (United States)

    Danko, Melissa E; Skinner, Michael A

    2006-06-01

    We provide a summary of the literature published in the past year addressing the surgical approach to multiple endocrine neoplasia type 2 in the pediatric population. The review focuses first on medullary thyroid carcinoma and performing prophylactic thyroidectomy for the prevention or cure of this disease. The timing and extent of surgery as well as additional surgical intervention for persistent or recurrent disease is discussed. Then the surgical management of hereditary pheochromocytoma is reviewed. Surgery is often the only treatment that can prevent or cure the endocrinopathies associated with multiple endocrine neoplasia type 2. Determining the proper timing and extent of surgical intervention in children affected with multiple endocrine neoplasia type 2 will lead to better outcomes and survival.

  12. Diagnosis and Medical Management of Ocular Surface Squamous Neoplasia.

    Science.gov (United States)

    Sayed-Ahmed, Ibrahim O; Palioura, Sotiria; Galor, Anat; Karp, Carol L

    2017-01-01

    Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN). The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that can differentiate OSSN from other ocular surface lesions. This review highlights the current regimens and diagnostic modalities used in managing OSSN. A review of the literature was performed using the keywords "conjunctival intraepithelial neoplasia", "ocular surface squamous neoplasia", "optical coherence tomography", "interferon-α2b", "5-fluorouracil" and "mitomycin C". Topical chemotherapy for OSSN can be used as primary therapy, for chemoreduction prior to surgical excision, and postoperatively to prevent tumor recurrence. It has the advantage of treating microscopic disease as well as large tumors. HR-OCT provides an "optical biopsy" that can assist in diagnosis and guide management of OSSN lesions.

  13. Elective cesarean hysterectomy for treatment of cervical neoplasia. An update.

    Science.gov (United States)

    Hoffman, M S; Roberts, W S; Fiorica, J V; Angel, J L; Finan, M A; Cavanagh, D

    1993-03-01

    From January 1, 1979, to March 31, 1991, 37 patients underwent elective cesarean hysterectomy for early cervical neoplasia. Thirty-four patients had cervical intraepithelial neoplasia III, and three patients had stage IA-1 squamous cell carcinoma of the cervix. Twenty-eight were primary cesarean sections; nine had obstetric indications. The mean operative time was 128 minutes; mean estimated blood loss was 1,400 mL. One patient experienced an intraoperative hemorrhage (3,500 mL). There were no other recognized intraoperative complications. Four significant postoperative complications included a vaginal cuff abscess, a wound dehiscence and pelvic abscess, one patient with febrile morbidity and an ileus and ligation with partial transection of a ureter. Patients were discharged on a mean of postoperative day 5.7. Although significant complications occurred, we believe that the noncompliant nature of our patient population justifies elective cesarean hysterectomy for treatment of cervical neoplasia.

  14. Long-term adherence to follow-up after treatment of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Barken, Sidsel S; Lynge, Elsebeth; Andersen, Erik S.

    2013-01-01

    OBJECTIVE: To measure adherence to annual follow-up among women treated for cervical intraepithelial neoplasia. DESIGN: Prospective, population-based, register study. SETTING: Denmark, 1996-2007. POPULATION: All women treated for cervical intraepithelial neoplasia with conization. METHODS: Treate...

  15. Neoplasia intraepitelial vulvar: um problema atual Vulvar intraepithelial neoplasia: a current problem

    Directory of Open Access Journals (Sweden)

    José Alberto Fonseca-Moutinho

    2008-08-01

    Full Text Available A neoplasia intraepitelial da vulva (VIN é uma denominação que foi introduzida incialmente pela International Society for Study of Vulvo-vaginal Diseases (ISSVD e reconhecida posteriormente pela International Society of Gynaecological Pathology (ISGYP e Organização Mundial da Saúde. É uma entidade patológica a que correspondem as VIN de tipo usual (verrucoso, basalióide e misto e as VIN de tipo diferenciado. A incidência das lesões de VIN tem aumentado progressivamente, principalmente em mulheres jovens. A infecção pelo papilomavírus humano (HPV de alto risco, pelo vírus da imunodeficiência humana (HIV, o tabagismo e a neoplasia intraepitelial do colo do útero, da vagina e região anal são factores de risco estabelecidos para as VIN. Não existem sintomas e sinais característicos das VIN, mas a doença se traduz sempre por lesões clinicamente identificáveis. A biópsia com o auxílio do colposcópio permite o diagnóstico. O tratamento da doença está sempre justificado pelo elevado risco de progressão para cancro invasivo. A excisão alargada das lesões ou a sua destruição com laser CO2 têm sido os métodos mais populares de tratamento. Independentemente do método terapêutico utilizado, as taxas de recidiva são elevadas, pelo que está aconselhada a vigilância apertada das doentes após tratamento. A terapêutica tópica com imiquimod se afigura promissora no tratamento das VIN. As vacinas profiláticas contra os tipos de HPV de alto risco prometem se tornar armas poderosas na prevenção primária da doença.Vulvar intraepithelial neoplasia (VIN is a pathological denomination coined by the International Society for Study of Vulvo-vaginal Diseases (ISSVD and adopted by the International Society of Gynaecological Pathology (ISGYP and by the World Health Organization. VIN is a heterogeneous pathological entity with a usual type (warty, basaloid and mixed and a differentiated type. The incidence of the disease is

  16. Epithelial neoplasia in Drosophila entails switch to primitive cell states.

    Science.gov (United States)

    Khan, Sumbul J; Bajpai, Anjali; Alam, Mohammad Atif; Gupta, Ram P; Harsh, Sneh; Pandey, Ravi K; Goel-Bhattacharya, Surbhi; Nigam, Aditi; Mishra, Arati; Sinha, Pradip

    2013-06-11

    Only select cell types in an organ display neoplasia when targeted oncogenically. How developmental lineage hierarchies of these cells prefigure their neoplastic propensities is not yet well-understood. Here we show that neoplastic Drosophila epithelial cells reverse their developmental commitments and switch to primitive cell states. In a context of alleviated tissue surveillance, for example, loss of Lethal giant larvae (Lgl) tumor suppressor in the wing primordium induced epithelial neoplasia in its Homothorax (Hth)-expressing proximal domain. Transcriptional profile of proximally transformed mosaic wing epithelium and functional tests revealed tumor cooperation by multiple signaling pathways. In contrast, lgl(-) clones in the Vestigial (Vg)-expressing distal wing epithelium were eliminated by cell death. Distal lgl(-) clones, however, could transform when both tissue surveillance and cell death were compromised genetically and, alternatively, when the transcription cofactor of Hippo signaling pathway, Yorkie (Yki), was activated, or when Ras/EGFR signaling was up-regulated. Furthermore, transforming distal lgl(-) clones displayed loss of Vg, suggesting reversal of their terminal cell fate commitment. In contrast, reinforcing a distal (wing) cell fate commitment in lgl(-) clones by gaining Vg arrested their neoplasia and induced cell death. We also show that neoplasia in both distal and proximal lgl(-) clones could progress in the absence of Hth, revealing Hth-independent wing epithelial neoplasia. Likewise, neoplasia in the eye primordium resulted in loss of Elav, a retinal cell marker; these, however, switched to an Hth-dependent primitive cell state. These results suggest a general characteristic of "cells-of-origin" in epithelial cancers, namely their propensity for switch to primitive cell states.

  17. Learning discriminative classification models for grading anal intraepithelial neoplasia

    Directory of Open Access Journals (Sweden)

    Kainz Philipp

    2016-09-01

    Full Text Available Grading intraepithelial neoplasia is crucial to derive an accurate estimate of pre-cancerous stages and is currently performed by pathologists assessing histopathological images. Inter- and intra-observer variability can significantly be reduced, when reliable, quantitative image analysis is introduced into diagnostic processes. On a challenging dataset, we evaluated the potential of learning a classifier to grade anal intraepitelial neoplasia. Support vector machines were trained on images represented by fractal and statistical features. We show that pursuing a learning-based grading strategy yields highly reliable results. Compared to existing methods, the proposed method outperformed them by a significant margin.

  18. Clinical case: multiple endocrine neoplasia type 1 (MEN 1

    Directory of Open Access Journals (Sweden)

    A K Lipatenkova

    2012-12-01

    Full Text Available Multiple endocrine neoplasia syndrome type 1 (MEN1, Wermer syndrome – group o а heterogeneous inherited deseases, caused by hyperlasia or neoplasia of several endocrine glands. The phenotype of MEN1 is broad, and over 20 different combinations of endocrine and non-endocrine metabolic manifestations have been described. This case demonstrates multiple formations of endocrine organs, starting non-classical with macroprolactonoma resistant to dopamine agonists therapy, other endocrine disorders developed gradually eventually: hyperparathyreoidism and hypoglycemia caused by pancreas lesions, produced proinsulin in high levels.

  19. Association of human immunodeficiency virus-induced immunosuppression with human papillomavirus infection and cervical intraepithelial neoplasia.

    Science.gov (United States)

    Henry, M J; Stanley, M W; Cruikshank, S; Carson, L

    1989-02-01

    Human papillomavirus infection plays an important causal role in cervical intraepithelial neoplasia and carcinoma. The rate of infection with human papillomavirus as well as the incidence of cervical intraepithelial neoplasia and carcinoma are increased in immunosuppressed patients. We report a possible association between infection with human immunodeficiency virus and cervical intraepithelial neoplasia with human papillomavirus infection.

  20. Las Sinapsis

    National Research Council Canada - National Science Library

    Jorge Eduardo Duque Parra; Genaro Morales Parra; Carlos Alberto Duque Parra

    1997-01-01

    ...’, dichas sustancias se vierten en las zonas de resquicio neuromuscular, neuroneuronal o neuroglandular, para modificar las condiciones de membrana y permitir la continuidad de los potenciales de acción...

  1. Calidad de vida de pacientes con obstrucción maligna del esófago, la vía biliar y la vía urinaria sometidos a intervencionismo radiológico paliativo Informe preliminar Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Jorge Guzmán Tatis

    2005-02-01

    Full Text Available En el momento de hacer el diagnóstico de los tumores malignos que ocasionan obstrucción del esófago, la vía biliar y el tracto urinario, la mayoría de los pacientes no tiene otras opciones terapéuticas excepto los cuidados paliativos. La presencia de síntomas molestos e incapacitantes, así como la amenaza a la existencia y el miedo a la muerte comprometen la calidad de vida. En este trabajo se realizaron a 25 pacientes procedimientos intervencionistas radiológicos como fueron: prótesis metálicas autoexpandibles en el esófago y en la vía biliar y nefrostomía percutánea. Se evaluaron, antes del procedimiento y a los 1, 3 y 6 meses la evolución de los síntomas clínicos, los criterios paraclínicos, las complicaciones de los procedimientos, el dolor por medio de la escala análoga visual y la calidad de vida por medio del cuestionario SF36. En los 8 pacientes con cáncer del esófago mejoraron el dolor y la disfagia y se mantuvieron el índice de masa corporal y la calidad de vida. En los 11 con obstrucción urinaria mejoraron el nitrógeno ureico, la creatinina y la calidad de vida al primer mes y al tercero. En los 6 que tenían obstrucción maligna de la vía biliar mejoraron los niveles de bilirrubina, el prurito, las náuseas y la calidad de vida al mes, con estabilidad del estado nutricional.

  2. Virus como inductores de neoplasias cutáneas Viruses as agents inducing cutaneous neoplasms

    Directory of Open Access Journals (Sweden)

    Francisco Bravo Puccio

    2013-03-01

    Full Text Available El rol oncogénico de los virus en las neoplasias cutáneas es conocido por el hombre desde hace más de un siglo, cuando se atribuía el origen de la verruga vulgar al virus papiloma humano (VPH. En la actualidad, las neoplasias inducidas por virus pueden agruparse en tumores sólidos y procesos linfoproliferativos. Destacan entre los primeros el VPH, del cual ahora conocemos numerosos serotipos, cada uno vinculado a una neoplasia específica, el herpesvirus humano tipo 8 que produce el sarcoma de Kaposi y el poliomavirus vinculado al carcinoma de Merkel. Entre los procesos linfoproliferativos debemos mencionar al virus linfotrópico de células T humanas tipo 1 (HTLV-1 responsable de los linfomas de células T, en los cuales el compromiso cutáneo es inespecífico, con un amplio espectro de presentaciones clínicas y, que por consiguiente, plantean un reto para el diagnóstico diferencial. En este grupo también se encuentra el virus Epstein Barr vinculado a los linfomas nasales de Células NK/T y a los linfomas tipo Hidroa, de reciente descripción. En esta era en la que lo genético y lo molecular priman en las investigaciones en cáncer, no podemos dejar de lado el concepto de neoplasia como resultado de la infección por un agente viral, lo que abre una nueva veta de posibilidades de tratamiento anticanceroso basado en medicamentos antiviralesThe oncogenic role of viruses in cutaneous neoplasms has been known by humankind for more than a century, when the origin of the common wart, or verruca vulgaris, was attributed to the human papilloma virus (HPV. Currently, virus-induced cutaneous neoplasms may be grouped into solid tumors and lymphoproliferative disorders. HPV, from which various serotypes are now known, each being linked to a specific neoplasm, the human herpes virus type 8 producing Kaposi sarcoma, and the Merkel cell polyomavirus, highlight among the first group. Regarding the lymphoproliferative disorders, we should mention the

  3. Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia.

    LENUS (Irish Health Repository)

    Alazzam, Mo'iad

    2012-12-01

    Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. Various salvage regimens are used worldwide. It is unclear which regimens are the most effective and the least toxic.

  4. In vivo and in vitro hyperspectral imaging of cervical neoplasia

    Science.gov (United States)

    Wang, Chaojian; Zheng, Wenli; Bu, Yanggao; Chang, Shufang; Tong, Qingping; Zhang, Shiwu; Xu, Ronald X.

    2014-02-01

    Cervical cancer is a prevalent disease in many developing countries. Colposcopy is the most common approach for screening cervical intraepithelial neoplasia (CIN). However, its clinical efficacy heavily relies on the examiner's experience. Spectroscopy is a potentially effective method for noninvasive diagnosis of cervical neoplasia. In this paper, we introduce a hyperspectral imaging technique for noninvasive detection and quantitative analysis of cervical neoplasia. A hyperspectral camera is used to collect the reflectance images of the entire cervix under xenon lamp illumination, followed by standard colposcopy examination and cervical tissue biopsy at both normal and abnormal sites in different quadrants. The collected reflectance data are calibrated and the hyperspectral signals are extracted. Further spectral analysis and image processing works are carried out to classify tissue into different types based on the spectral characteristics at different stages of cervical intraepithelial neoplasia. The hyperspectral camera is also coupled with a lab microscope to acquire the hyperspectral transmittance images of the pathological slides. The in vivo and the in vitro imaging results are compared with clinical findings to assess the accuracy and efficacy of the method.

  5. Imaging Finding of Multiple Endocrine Neoplasia Type 1: Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Yum, Tae Jun; Cho, Hee Woo [Dept. of Radiology, Yonsei University, College of Medicine, Seoul (Korea, Republic of)

    2012-08-15

    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited syndrome with characteristic clinical and radiological manifestations. Many reports on MEN1 have been published; however, no cases of radiologically diagnosed MEN1 have been reported. Therefore, we report on a radiologically diagnosed case of MEN1 with clinical symptoms of gastroduodenal ulcer.

  6. Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Lehtinen, Matti; Ault, Kevin A; Lyytikainen, Erika

    2011-01-01

    High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined....

  7. Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1

    NARCIS (Netherlands)

    Lodewijk, Lutske; Bongers, Pim J.; Kist, Jakob W.; Conemans, Elfi B.; de Laat, Joanne M.; Pieterman, Carla R. C.; van der Horst-Schrivers, Anouk N. A.; Jorna, Ciska; Hermus, Ad R.; Dekkers, Olaf M.; de Herder, Wouter W.; Drent, Madeleine L.; Bisschop, Peter H.; Havekes, Bas; Rinkes, Inne H. M. Borel; Vriens, Menno R.; Valk, Gerlof D.

    2015-01-01

    Objective: Currently, little is known about the prevalence of thyroid tumors in multiple endocrine neoplasia type 1 (MEN1) patients and it is unclear whether tumorigenesis of these thyroid tumors is MEN1-related. The aim of the study was to assess the prevalence of thyroid incidentalomas in MEN1 pat

  8. Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1

    NARCIS (Netherlands)

    Lodewijk, Lutske; Bongers, Pim J; Kist, Jakob W; Conemans, Elfi B; de Laat, Joanne M; Pieterman, Carla R C; van der Horst-Schrivers, Anouk N A; Jorna, Ciska; Hermus, Ad R; Dekkers, Olaf M; de Herder, Wouter W; Drent, Madeleine L; Bisschop, Peter H; Havekes, Bas; Rinkes, Inne H M Borel; Vriens, Menno R; Valk, Gerlof D.

    2015-01-01

    OBJECTIVE: Currently, little is known about the prevalence of thyroid tumors in multiple endocrine neoplasia type 1 (MEN1) patients and it is unclear whether tumorigenesis of these thyroid tumors is MEN1-related. The aim of the study was to assess the prevalence of thyroid incidentalomas in MEN1 pat

  9. Manejo dos portadores das neoplasias intraepiteliais anais Managment of anal intra-epithelial neoplasia patients

    Directory of Open Access Journals (Sweden)

    Sidney Roberto Nadal

    2008-12-01

    Full Text Available Acredita-se que a neoplasia intraepitelial anal (NIA, provocada pelo HPV, seja a lesão precursora do carcinoma anal. Segundo a literatura, são encontradas entre 11% e 52% dos homens infectados pelo HIV, entre 6% a 20% dos homens e 1% a 2,8% das mulheres sem essa infecção. Entre 8,5% e 13% das NIA de alto grau evoluirão para carcinoma invasivo, indicando a necessidade do rastreamento e do seguimento desses doentes para prevenção. Não há tratamento satisfatório com baixos índices de morbidez e a recidiva é comum. Em geral, as formas de tratamento podem de ser divididas em tópicas, entre elas, ácido tricloroacético, podofilina, podofilotoxina, imiquimod, terapia fotodinâmica, e ablativas, ou seja, excisão cirúrgica, ablação pelo LASER, coagulação pelo infravermelho e eletrofulguração. Há, ainda, os que consideram aceitável a conduta expectante. O tratamento tópico se justifica pelo caráter multifocal da lesão e os ablativos têm taxas de complicação e recidiva muito semelhantes. De qualquer forma, doentes com qualquer anormalidade histológica necessitam de seguimento adequado, principalmente com colposcopia e citologia anal.Anal intra-epithelial neoplasia (AIN, provoked by HPV, is considered as an anal cancer precursor. Some articles noticed that it occurred among 11% and 52% of men who have sex with men (MSM infected with HIV and, among seronegatives, from 6% to 20% of men and from 1% to 2.8% of women. From 8.5% to 13% of high grade AIN will evolve to invasive carcinoma, needing follow-up and screening for prevention. There is no satisfactory treatment with low morbidity and recurrence is frequent. There are two main forms of treatment: topics (trichloroacetic acid, podophylin, podophylotoxin, imiquimod, photodynamic therapy and ablatives (chirurgical excision, LASER, infrared, eletrocautery. Others consider acceptable an expectant management. Topical therapy is justified because of multifocal presentation of HPV

  10. The "spaghetti technique": an alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma).

    Science.gov (United States)

    Gaudy-Marqueste, Caroline; Perchenet, Anne-Sophie; Taséi, Anne-Marie; Madjlessi, Nika; Magalon, Guy; Richard, Marie-Aleth; Grob, Jean-Jacques

    2011-01-01

    Lentigo maligna (LM) and acral lentiginous melanoma (ALM) are often large and clinically ill defined. The surgical challenge is to spare tissue while still achieving clear margins. We sought to provide a retrospective assessment of a two-phase surgical technique for lentiginous melanomas (MM) not suitable for en bloc resection. In the first phase, a narrow band of skin, "the spaghetti", is resected just beyond the clinical outline of the MM, immediately sutured, and sent for pathological examination without removing the MM. The same procedure is repeated beyond the segments which are shown to be not tumor free and so forth until the minimal tumor-free perimeter is outlined. No operative wound is left between operative sessions. In the second phase, the MM resection and reconstruction are performed at the same time. In 21 patients with LM (n = 16) or ALM (n = 5), the mean operative defect size was 27.5 cm(2) (range, 1.97-108.4 cm(2)). The mean number of steps in the procedure was 1.55 (1-4). Grafts were used for reconstruction in all cases. The relevance of the "spaghetti"-defined outline was confirmed in 19 of 21 patients. After a median follow-up period of 25.36 months (range, 0-72 months), the local control rate was 95.24% with one case (4.76%) of in-transit invasive recurrence after 48 months. This study was performed at a single center and included a limited number of patients. The follow-up time was relatively brief. The "spaghetti technique" is simple and reliable for LM and ALM. Unlike Mohs surgery, it does not require specific training of surgeons or pathologists. Unlike staged surgery, it does not leave patients with an open wound on the face or soles before final reconstruction. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  11. Estudio mediante modelado y simulación del efecto de la isquemia miocárdica aguda en las fibras de Purkinje de corazón humano

    OpenAIRE

    GARCÍA ESCOLANO, ALBA

    2016-01-01

    [ES] Las enfermedades cardiovasculares constituyen una de las principales causas de muerte en el mundo. Dentro de este tipo de patologías destaca la isquemia miocárdica como consecuencia de la oclusión de una arteria coronaria. Dicha condición aumenta la predisposición al inicio y mantenimiento de arritmias malignas, como la fibrilación ventricular, que tienen su origen en reentradas. Por ello, es necesario estudiar los mecanismos biológicos que son alterados durante la isquemia y...

  12. O cuidado paliativo domiciliar sob a ótica de familiares responsáveis pela pessoa portadora de neoplasia El cuidado paliativo domiciliar en la óptica de familiares de la persona con neoplasia Palliative home care in the view of families of a person with neoplasia

    Directory of Open Access Journals (Sweden)

    Cláudia Adriana Moraes e Silva

    2007-04-01

    Full Text Available Trata-se de uma pesquisa qualitativa cujo objetivo principal foi conhecer como o familiar vivencia o cuidado paliativo domiciliar dispensado à pessoa portadora de neoplasia. Utilizou-se a entrevista semi-estruturada para a coleta de informações. Os sujeitos foram oito pessoas que cuidam de pacientes vinculados ao serviço de oncologia regional. As informações foram analisadas através da Análise de Conteúdo de Bardin e referem-se à descrição dos motivos, significados e dificuldades vivenciados pelo familiar no cuidado domiciliar. Concluímos que as vivências mais significativas estão associadas aos motivos que levaram as mulheres a dispensarem o cuidado e que as vivências são permeadas por dificuldades econômicas e por sentimentos de gratidão, apego, amor, retribuição, medos, culpas e conflitos.El objetivo principal de esta investigación cualitativa ha sido conocer como las personas de la familia vivencían el cuidado domiciliario a la persona portadora de neoplasia en tratamiento paliativo. Se ha utilizado la entrevista semiestructurada para recoger las informaciones. Los sujetos han sido ocho personas que cuidan de pacientes vinculados al servicio de oncología regional. Se ha analizado las informaciones a través del Análisis de Contenido de Bardin y éstas se refieren a la descripción de los motivos, significados y dificultades vivenciados. Llegamos a la conclusión que las vivencias más significativas están asociadas a los motivos que han llevado a las mujeres al desarrollo del cuidado y son permeadas por dificultades económicas y por sentimientos de gratitud, apego, amor, retribución, miedos, culpas y conflictos.This is a qualitative research that aimed at knowing how the subject's family experiences palliative care in home for people with neoplasia. We have used a semi-structural interview for data collection. There were eight practitioners taking care of regional oncology service subjects. Data were analysed

  13. Sobrevida de pacientes com estenose biliar maligna baseada no escovado endoscópico e na bilirrubinemia Survival of patients with malignant biliary stricture based on endoscopic brushing and on bilirubinemia

    Directory of Open Access Journals (Sweden)

    Laura Cotta Ornellas

    2004-09-01

    Full Text Available RACIONAL: As principais causas de estenose biliar maligna são câncer de pâncreas e colangiocarcinoma. A definição do prognóstico dos pacientes no momento da pancreatocolangiografia retrógrada endoscópica é importante na escolha da conduta mais adequada. OBJETIVO: Avaliar a importância do escovado endoscópico e da bilirrubinemia na determinação da sobrevida dos pacientes com estenose biliar maligna. MÉTODOS: Os pacientes com estenose biliar diagnosticados durante pancreatocolangiografia retrógrada endoscópica foram submetidos a duplo escovado. Amostras de sangue de todos eles foram obtidas para dosagem das bilirrubinas. Os pacientes foram acompanhados para determinar o diagnóstico final e a sobrevida. RESULTADOS: Diagnóstico final de doença maligna foi obtido em 40 pacientes de um total de 50 casos de estenose biliar. Os níveis séricos elevados das bilirrubinas ou a citologia por escovado positiva para malignidade estava relacionada a menor sobrevida. CONCLUSÃO: Os dados desta pesquisa demonstram a possibilidade de determinar o prognóstico em casos de estenoses biliares malignas através do resultado do escovado endoscópico ou da bilirrubinemia.BACKGROUND: Pancreatic cancer and cholangiocarcinoma are the main causes of malignant biliary stricture. Both types of cancers have dismal survival rates, and treatment has little or no effect on prolonging the patients lives. Prognostic definition at initial endoscopic retrograde cholangiopancreatography is important to choose the most suitable management. AIM: To analyse endoscopic brushing and bilirubinemia importance in determination of the survival of patients with malignant biliary stricture. METHODS: Patients with biliary strictures diagnosed during endoscopic retrograde cholangiopancreatography were submitted to double brushing cytology. Serum samples were taken from all patients for bilirubinemia assay. Patients were followed to determine the final diagnosis and survival

  14. Comparação dos métodos de imagem no diagnóstico dos tumores renais e calcificações nestas neoplasias Comparison of imaging methods for diagnosis of renal tumors and their calcifications

    Directory of Open Access Journals (Sweden)

    Sergio Marrone Ribeiro

    2004-12-01

    Full Text Available OBJETIVO: Tentar estabelecer uma metodologia no diagnóstico e conduta dos pacientes com massas renais sólidas e complexas, comparando os custos e benefícios dos diferentes métodos de diagnóstico por imagem. Procuramos avançar no diagnóstico diferencial entre lesões benignas e malignas, particularmente através da investigação das calcificações tumorais. MÉTODOS: Realizamos um estudo prospectivo em 31 pacientes portadores de massas renais sólidas ou complexas, todos eles submetidos à ultra-sonografia abdominal (US, ultra-sonografia doppler da massa renal (US Dop, tomografia computadorizada (TC e ressonância magnética (RM. RESULTADOS: Encontramos 28 pacientes com massas malignas e três com massas benignas. Entre os 28 pacientes com lesões malignas, 17 mostraram calcificações pela TC; 16 deles calcificações do tipo central e um calcificação do tipo curvilinear periférica pura (casca de ovo. A urografia excretora (UGE mostrou uma taxa de detecção para calcificações significantemente menor que a US e a TC. Massas benignas e malignas apareceram como descrito na literatura, com o US, TC e RM mostrando alta sensibilidade e especificidade no diagnóstico dos tumores renais. A exceção foi na US Dop, onde nós obtivemos menor sensibilidade para a caracterização de fluxo tumoral maligno. CONCLUSÕES: Foi surpreendente verificar que a TC revelou calcificações centrais em 51,6% dos pacientes desta série, todas elas em lesões malignas, quando a literatura refere uma freqüência de calcificações entre 8% e 22% dos carcinomas de células renais, em estudos utilizando radiografias simples do abdômen e UGE. Este achado é de grande importância quando consideramos que estas calcificações ocorrem particularmente em neoplasias malignas. Como resultado da comparação dos diferentes métodos de diagnóstico por imagem, nós propomos uma metodologia para adequada investigação dos tumores renais.BACKGROUND: To establish the

  15. Multiple endocrine neoplasia type 2: achievements and current challenges

    Directory of Open Access Journals (Sweden)

    Andreas Machens

    2012-01-01

    Full Text Available Incremental advances in medical technology, such as the development of sensitive hormonal assays for routine clinical care, are the drivers of medical progress. This principle is exemplified by the creation of the concept of multiple endocrine neoplasia type 2, encompassing medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism, which did not emerge before the early 1960s. This review sets out to highlight key achievements, such as joint biochemical and DNA-based screening of individuals at risk of developing multiple endocrine neoplasia type 2, before casting a spotlight on current challenges which include: (i ill-defined upper limits of calcitonin assays for infants and young children, rendering it difficult to implement the biochemical part of the integrated DNA-based/biochemical concept; (ii our increasingly mobile society in which different service providers are caring for one individual at various stages in the disease process. With familial relationships disintegrating as a result of geographic dispersion, information about the history of the origin family may become sketchy or just unavailable. This is when DNA-based gene tests come into play, confirming or excluding an individual's genetic predisposition to multiple endocrine neoplasia type 2 even before there is any biochemical or clinical evidence of the disease. However, the unrivaled molecular genetic progress in multiple endocrine neoplasia type 2 does not come without a price. Screening may uncover unknown gene sequence variants representing either harmless polymorphisms or pathogenic mutations. In this setting, functional characterization of mutant cells in vitro may generate helpful ancillary evidence with regard to the pathogenicity of gene variants in comparison with established mutations.

  16. Risk of cervical intraepithelial neoplasia in women with glomerulonephritis.

    OpenAIRE

    Hartveit, F.; Bertelsen, B; Thunold, S; Maehle, B O; Skaarland, E; J. Christensen

    1991-01-01

    OBJECTIVE--To investigate the occurrence of cervical intraepithelial neoplasia in women with glomerulonephritis and its possible association with immunosuppressive treatment. DESIGN--Retrospective study of cytological or histological specimens from women presenting with glomerulonephritis and a group of case and age matched controls. SETTING--University department of pathology, Norway. PATIENTS--81 women presenting with glomerulonephritis from 1981 to 1988, from whom gynaecological cytologica...

  17. The prevalence and characteristics of colorectal neoplasia in acromegaly.

    Science.gov (United States)

    Renehan, A G; Bhaskar, P; Painter, J E; O'Dwyer, S T; Haboubi, N; Varma, J; Ball, S G; Shalet, S M

    2000-09-01

    An increased prevalence of colorectal neoplasia has been reported in acromegalic patients, and recommendations have been made for early colonoscopic screening and regular surveillance. This assumption, however, is frequently drawn from studies using selected control populations. To clarify colonoscopic management in these patients, we undertook a 2-center prospective screening colonoscopy study in 122 acromegalics (age range, 25-82 yr). In the absence of ideal age-matched controls, we calculated prevalence rates of occult adenocarcinomas and adenomas in the general population using cumulative data in the published literature from 8 autopsy studies (model 1, n = 3,559) and 4 screening colonoscopy studies (model 2, n= 810), applying linear regression models. Of the 115 patients with complete examinations, adenocarcinomas were discovered in 3 (2.6%), and at least 1 adenoma was found in 11, giving an overall prevalence of neoplasia of 12% (14 of 115). Prevalence rates for age bands 30-40, 40-49, 50-59, 60-69, and 70+ yr were 0%, 8%, 12%, 20%, and 21%, respectively. Compared with the 2 control models, the prevalence of occult colorectal cancer was not significantly increased (acromegalics vs. models 1 and 2, 2.6% vs. 2.3% and 0.9%), nor was there an increase in the prevalence of adenomas in any age band. Pathological characteristics showed some differences, in that adenomas in acromegalics tended to be right sided (68% vs. 57% and 56%), larger (for > or =10 mm, 27% vs. 13% and 9%), and of advanced histology (for tubulovillous, 27% vs. 4% and 22%). No associations were found between the presence of colonic neoplasia and the duration of disease, total GH exposure, cure status, and serum insulin-like growth factor I. This study has failed to demonstrate an increased prevalence of neoplasia in acromegalic patients compared with the expected prevalence in the general population and questions the need for an aggressive colonoscopic screening policy.

  18. Piroxicam decreases postirradiation colonic neoplasia in the rat

    Energy Technology Data Exchange (ETDEWEB)

    Northway, M.G.; Scobey, M.W.; Cassidy, K.T.; Geisinger, K.R. (Wake Forest Univ., Winston Salem, NC (USA))

    1990-12-01

    This study evaluated the effects of the nonsteroidal antiinflammatory agent piroxicam on chronic radiation proctitis in the rat. Forty female Wistar rats received a 2250-cGy dose of irradiation to the distal 2 cm of the colon. Twenty received piroxicam 8.0 mg/kg orally 30 minutes before exposure and 24 hours after exposure; 20 rats served as irradiated controls. All animals were evaluated by colonoscopy 1 and 3 weeks postexposure and every third week until death or killing at 1 year. At killing, colons were removed for light microscopic examination. One year postirradiation results showed no differences in mortality, vascular changes, acute inflammation, colitis cystica profunda, or rectal stricture between the control and piroxicam-treated groups. However, at 1 year postirradiation the control group demonstrated neoplasia in 15 of 19 animals compared with eight of 20 animals in the piroxicam-treated group. The first endoscopic appearance of colonic neoplasm occurred at 15 weeks postirradiation in one control irradiated rat whereas the first evidence of endoscopic neoplasm in the piroxicam-treated group did not occur until 36 weeks postirradiation. Histologic examination documented a tendency toward a greater presence of adenocarcinomas in the control group compared with the piroxicam-treated group. The authors conclude that piroxicam treatment significantly decreased the incidence of colonic neoplasia in general as well as delayed the endoscopic appearance of colonic neoplasia in rats after pelvic irradiation. 41 references.

  19. Síndrome neuroléptica maligna de paciente em uso de olanzapina Neuroleptic malignant syndrome in patient using olanzapine

    Directory of Open Access Journals (Sweden)

    Fabrício Lins de Medeiros

    2008-01-01

    Full Text Available A síndrome neuroléptica maligna (SNM é uma reação idiossincrásica rara, extremamente grave e potencialmente fatal ao uso de antipsicóticos, tanto típicos quanto atípicos, bem como drogas de ação dopaminérgica. O diagnóstico fundamenta-se em critérios clínicos e laboratoriais e exclusão de outras condições médicas gerais ou psiquiátricas que melhor expliquem os sintomas. Segundo o DSM-IV, os principais critérios são rigidez muscular grave e temperatura elevada, associadas ao uso de medicação antipsicótica. Foi relatado um caso de paciente com 30 anos manifestando história de transtorno afetivo bipolar, que apresentou sinais e sintomas consistentes com SNM, após três semanas de tratamento com olanzapina. Esse relato visa a discutir o risco da SNM ao uso de antipsicóticos atípicos, bem como a importância de diagnóstico precoce e intervenção imediata.Neuroleptic malignant syndrome (NMS is an idiosyncratic, serious and potentially fatal disorder observed in patients who receive treatment with neuroleptics, typical and atypical, as well as medications with dopaminergic effects. The diagnosis is based on clinical and laboratory criteria and the exclusion of other general medical or psychiatric conditions that could best explain the symptoms. The main criteria according to DSM-IV are severe rigidity and fever associated with the use of antipsychotic medication. We present a case of a 30-year-old female with history of bipolar affective disorder that developed signs and symptoms consistent with NMS after three weeks of treatment with Olanzapine. This case aims to address the risk of NMS associated atypical antipsychotic, as well as the importance of an early diagnosis and immediate intervention.

  20. Surgical treatment of pancreatic endocrine tumors in multiple endocrine neoplasia type 1

    Directory of Open Access Journals (Sweden)

    Marcel Cerqueira Cesar Machado

    Full Text Available Surgical approaches to pancreatic endocrine tumors associated with multiple endocrine neoplasia type 1 may differ greatly from those applied to sporadic pancreatic endocrine tumors. Presurgical diagnosis of multiple endocrine neoplasia type 1 is therefore crucial to plan a proper intervention. Of note, hyperparathyroidism/multiple endocrine neoplasia type 1 should be surgically treated before pancreatic endocrine tumors/multiple endocrine neoplasia type 1 resection, apart from insulinoma. Non-functioning pancreatic endocrine tumors/multiple endocrine neoplasia type 1 >1 cm have a high risk of malignancy and should be treated by a pancreatic resection associated with lymphadenectomy. The vast majority of patients with gastrinoma/multiple endocrine neoplasia type 1 present with tumor lesions at the duodenum, so the surgery of choice is subtotal or total pancreatoduodenectomy followed by regional lymphadenectomy. The usual surgical treatment for insulinoma/multiple endocrine neoplasia type 1 is distal pancreatectomy up to the mesenteric vein with or without spleen preservation, associated with enucleation of tumor lesions in the pancreatic head. Surgical procedures for glucagonomas, somatostatinomas, and vipomas/ multiple endocrine neoplasia type 1 are similar to those applied to sporadic pancreatic endocrine tumors. Some of these surgical strategies for pancreatic endocrine tumors/multiple endocrine neoplasia type 1 still remain controversial as to their proper extension and timing. Furthermore, surgical resection of single hepatic metastasis secondary to pancreatic endocrine tumors/multiple endocrine neoplasia type 1 may be curative and even in multiple liver metastases surgical resection is possible. Hepatic trans-arterial chemo-embolization is usually associated with surgical resection. Liver transplantation may be needed for select cases. Finally, pre-surgical clinical and genetic diagnosis of multiple endocrine neoplasia type 1 syndrome and

  1. Laparoscopic wedge resection of synchronous gastric intraepithelial neoplasia and stromal tumor: A case report

    OpenAIRE

    2010-01-01

    Synchronous occurrence of epithelial neoplasia and gastrointestinal stromal tumor (GIST) in the stomach is uncommon. Only rare cases have been reported in the literature. We present here a 60-year-old female case of synchronous occurrence of gastric high-level intraepithelial neoplasia and GIST with the features of 22 similar cases and detailed information reported in the English-language literature summarized. In the present patient, epithelial neoplasia and GIST were removed en bloc by lapa...

  2. Vaginal cancer in a patient treated for cervical intraepithelial neoplasia (CIN 3): case report.

    Science.gov (United States)

    Androutsopoulos, G; Adonakis, G; Ravazoula, P; Kourounis, G

    2006-01-01

    In 1% to 3% of patients with cervical intraepithelial neoplasia (CIN), vaginal intraepithelial neoplasia (VAIN) will either coexist or occur at a later date. The time interval from an earlier diagnosis of CIN 3 to a current diagnosis of VAIN 3 varies from two to 17 years. Invasive vaginal cancer occurred in a woman five years after total abdominal hysterectomy for cervical intraepithelial neoplasia. In women who have undergone total hysterectomy for cervical intraepithelial neoplasia or cervical cancer, postoperative cytologic and colposcopic follow-up of the vagina is necessary.

  3. Colorectal neoplasia in patients with primary sclerosing cholangitis undergoing liver transplantation

    DEFF Research Database (Denmark)

    Jørgensen, Kristin Kaasen; Lindström, Lina; Cvancarova, Milada

    2012-01-01

    is controversial. We aimed to compare the risk of colorectal neoplasia in PSC-IBD patients before and after Ltx and to identify risk factors for colorectal neoplasia post-transplant. MATERIAL AND METHODS: In a multicenter study within the Nordic Liver Transplant Group, we assessed the risk of colorectal neoplasia......OBJECTIVE: Several studies have implicated primary sclerosing cholangitis (PSC) as an additional risk factor for colorectal neoplasia in inflammatory bowel disease (IBD). Some reports have indicated that the risk is even higher in PSC-IBD patients after liver transplantation (Ltx), but this issue...

  4. Presentación de una neoplasia de próstata como un síndrome febril.

    Directory of Open Access Journals (Sweden)

    Faustino A. Fando Rodríguez

    2009-03-01

    Full Text Available El adenocarcinoma de próstata es una causa importante de mortalidad en el hombre. Sus manifestaciones clínicas de inicio pueden adoptar diferentes formas, siendo las más frecuentes los síntomas urinarios y los dolores óseos, es infrecuente la fiebre. Se presenta el caso de un paciente masculino, de 78 años de edad que acude a consulta de Geriatría con un síndrome febril que motivó su ingreso y al ser evaluado por urología y hallarse una vesícula seminal palpable, se sospechó una neoplasia de próstata. La presencia de una fosfatasa ácida prostática y un anfígeno prostático específico elevado, apoyó el diagnóstico que posteriormente se confirmó histológicamente. La fiebre desapareció con el tratamiento hormonal de la neoplasia. Se concluye que en todo paciente masculino con un síndrome febril prolongado, es importante descartar un proceso neoplásico, y sobre todo de próstata que ocupa el segundo lugar en frecuencia.

  5. Morbilidad y mortalidad en una serie de pacientes con neoplasias del peritoneo, tratados con citorreducción peritoneal más quimioterapia hipertérmica intraperitoneal en el Hospital Universitario de la Fundación Santa Fe de Bogotá (ONCOLGroup - estudio ATIA

    Directory of Open Access Journals (Sweden)

    F. Arias

    2012-04-01

    Conclusiones: La cirugía citorreductiva más HIPEC en pacientes bien seleccionados con neoplasias las cuales afectan el peritoneo, resulta un procedimiento que se puede realizar en Colombia con un adecuado perfil de seguridad y eficacia. La mortalidad fue similar a lo reportado en la literatura mundial.

  6. Los tumores de la mama: hallazgos ecográficos más frecuentes en el policlínico “Gustavo Aldereguía Lima”, Las Tunas

    Directory of Open Access Journals (Sweden)

    Yecenia Velasco Diéguez

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal de pacientes femeninas que presentaron ecografía de mamas con resultado patológico, en el policlínico “Gustavo Aldereguía Lima” de la ciudad de Las Tunas, en el período comprendido de enero a diciembre de 2011. El universo de estudio estuvo conformado por 277 mujeres, a las que se les realizó algún ultrasonido de las mamas, quedando constituida la muestra por 95 pacientes, que presentaron imágenes ultrasonográficas de aspecto sólido. La información se obtuvo de la revisión del libro de registros de resultados de ultrasonidos, los informes correspondientes y de las historias clínicas de salud individual. Para procesarla se utilizó la estadística descriptiva. Las lesiones benignas se comportaron en su mayoría con baja ecogenicidad, homogéneas y de contornos regulares; las malignas, como imágenes complejas de contornos irregulares. Las histologías más diagnosticadas fueron los tumores benignos y dentro de ellos los fibroadenomas. Se recomendó continuar utilizando la ecografía de las mamas como método efectivo para el estudio de las lesiones tumorales de esta glándula y como complemento de gran valor para diagnosticar precozmente las lesiones malignas de este órgano.

  7. Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

    Science.gov (United States)

    Lin, Ming-Chieh; Lomo, Lesley; Baak, Jan P A; Eng, Charis; Ince, Tan A; Crum, Christopher P; Mutter, George L

    2009-02-01

    Squamous morules are a common component of premalignant glandular lesions that are followed by glandular, rather than squamous, carcinomas. We tested the hypothesis that the appearance of glands associated with morules predicts cancer risk, and undertook molecular testing to determine the clonal and hormonal response properties of admixed squamous and glandular elements. A total of 66 patients with squamous morules in an index endometrial biopsy had follow-up clinical data (average follow-up: interval 31 months, 2.5 biopsies) showing development of carcinoma in 11% (7/66) of cases. The histological appearance of morule-associated glands in the index biopsy was significantly associated with this clinical outcome, with the majority (71%, 5/7) of cancer occurrences following an overtly premalignant lesion (endometrial intraepithelial neoplasia) with squamous morules. Eight endometrial intraepithelial neoplasias with squamous morules were examined by immunohistochemistry for estrogen and progesterone receptors and mitotic activity (Ki-67 antigen percent stained). Glandular components had abundant estrogen and progesterone receptors, and high levels of mitotic activity in all cases. In sharp contrast, all squamous morules were devoid of sex hormone receptors and had undetectable or extremely low-proliferation rates. When mutated, the same specific PTEN mutation was detected in squamous and glandular elements, indicating that both are of common lineage. The clinical and laboratory data are consistent with a model of morule biology in which squamous morules are a hormonally incompetent subpopulation of endometrial glandular lesions. Isolated morules might result from artifactual displacement from their native glandular context, or selective hormonally induced regression of the glandular but not squamous components over time. Subsequent cancer risk, as promoted by estrogens, is greatest when the glandular component has the appearance of endometrial intraepithelial

  8. Nuevos métodos de detección de metástasis en corteza ovárica criopreservada de pacientes con cáncer de mama

    OpenAIRE

    Rodriguez Iglesias, Beatriz

    2015-01-01

    En la actualidad, se está produciendo un aumento de las tasas de supervivencia en determinadas formas de cáncer que se considera que afectan principalmente a niños y personas jóvenes, como las neoplasias hematológicas y ciertos tipos de tumores sólidos. El cáncer de mama es la neoplasia maligna más frecuente en mujeres en edad reproductiva y en muchos casos no han cumplido con su proyecto reproductivo. El tratamiento con dosis altas de quimioterapia y/o radioterapia en pacientes de sexo f...

  9. Risk of advanced colorectal neoplasia according to age and gender.

    Directory of Open Access Journals (Sweden)

    Frank T Kolligs

    Full Text Available BACKGROUND: Colorectal cancer (CRC is one of the leading causes of cancer related morbidity and death. Despite the fact that the mean age at diagnosis of CRC is lower in men, screening by colonoscopy or fecal occult blood test (FOBT is initiated at same age in both genders. The prevalence of the common CRC precursor lesion, advanced adenoma, is well documented only in the screening population. The purpose of this study was to assess the risk of advanced adenoma at ages below screening age. METHODS AND FINDINGS: We analyzed data from a census of 625,918 outpatient colonoscopies performed in adults in Bavaria between 2006 and 2008. A logistic regression model to determine gender- and age-specific risk of advanced neoplasia was developed. Advanced neoplasia was found in 16,740 women (4.6% and 22,684 men (8.6%. Male sex was associated with an overall increased risk of advanced neoplasia (odds ratio 1.95; 95% confidence interval, CI, 1.91 to 2.00. At any age and in any indication group, more colonoscopies were needed in women than in men to detect advanced adenoma or cancer. At age 75 14.8 (95% CI, 14.4-15.2 screening, 18.2 (95% CI, 17.7-18.7 diagnostic, and 7.9 (95% CI, 7.6-8.2 colonoscopies to follow up on a positive FOBT (FOBT colonoscopies were needed to find advanced adenoma in women. At age 50 39.0 (95% CI, 38.0-40.0 diagnostic, and 16.3 (95% CI, 15.7-16.9 FOBT colonoscopies were needed. Comparable numbers were reached 20 and 10 years earlier in men than in women, respectively. CONCLUSIONS: At any age and independent of the indication for colonoscopy, men are at higher risk of having advanced neoplasia diagnosed upon colonoscopy than women. This suggests that starting screening earlier in life in men than in women might result in a relevant increase in the detection of asymptomatic preneoplastic and neoplastic colonic lesions.

  10. [New challenges to the treatment of cervical intraepithelial neoplasia].

    Science.gov (United States)

    Sun, J H

    2016-07-01

    Due to the progress of intracavitary afterloading technology and dosage of brachytherapy, a similar dose distribution as that of cervical conization can be achieved and can be applied to the treatment of cervical intraepithelial neoplasia (CIN), it is called "afterloading conization" . Being adjusted the radioactive source movement and weight, low exposure doses to the ovary, endometrium and vagina can be assured. So a high quality of life after treatment could be maintained and overcomes the shortcomings of cervical conization and hysterectomy, such as anesthesia, bleeding, over or insufficient treatment, early ovarian ageing and operative complications.

  11. Photodynamic therapy of cervical intraepithelial neoplasia using hexaminolevulinate and methylaminolevulinate

    Science.gov (United States)

    Soergel, Philipp; Staboulidou, Ismini; Hertel, Herrmann; Schippert, Cordula; Hillemanns, Peter

    2009-06-01

    Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer. Previous studies indicated that photodynamic therapy (PDT) represents an effective treatment modality in CIN. In 28 patients with CIN 1 - 3, 1 - 2 cycles of PDT were conducted using hexaminolevulinate (HAL) or methylaminolevulinate (MAL) and a special light delivery system. After 6 months, biopsies were obtained to assess response. The overall response rate for complete or partial response was 65%. Photodynamic therapy using new ALA esters is effective and may offer unique advantages in the therapy of CIN.

  12. Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia

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    Mansukhani Mahesh

    2003-11-01

    Full Text Available Abstract Background The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factors relate to p53 status, particularly in early colorectal neoplasia prior to clinically invasive colorectal cancer (including adenomas, carcinoma in situ (CIS, and intramucosal carcinoma. Methods We examined p53 status, as measured by protein overexpression, in 157 cases with early colorectal neoplasia selected from three New York City colonoscopy clinics. After collecting paraffin-embedded tissue blocks, immunohistochemistry was performed using an anti-p53 monoclonal mouse IgG2a [BP53-12-1] antibody. We analyzed whether p53 status was different for risk factors for colorectal neoplasia relative to a polyp-free control group (n = 508. Results p53 overexpression was found in 10.3%, 21.7%, and 34.9%, of adenomatous polyps, CIS, and intramucosal cases, respectively. Over 90% of the tumors with p53 overexpression were located in the distal colon and rectum. Heavy cigarette smoking (30+ years was associated with cases not overexpressing p53 (OR = 1.8, 95% CI = 1.1–2.9 but not with those cases overexpressing p53 (OR = 1.0, 95% CI = 0.4–2.6. Heavy beer consumption (8+ bottles per week was associated with cases overexpressing p53 (OR = 4.0, 95% CI = 1.3–12.0 but not with cases without p53 overexpression (OR = 1.6, 95% CI = 0.7–3.7. Conclusion Our findings that p53 overexpression in early colorectal neoplasia may be positively associated with alcohol intake and inversely associated with cigarette smoking are consistent with those of several studies of p53 expression and invasive cancer, and suggest that there may be relationships of smoking and alcohol with p53 early in the adenoma to carcinoma sequence.

  13. Integumentary Disorders Including Cutaneous Neoplasia in Older Horses.

    Science.gov (United States)

    Knottenbelt, Derek C

    2016-08-01

    Few skin diseases specifically or exclusively affect older horses and donkeys. Hypertrichosis (hirsutism) associated with pituitary pars intermedia dysfunction is probably the most recognized and best understood exception and is the most common age-related skin condition in equids. Many other conditions are known to be more serious in older horses. Horses affected with immune-compromising conditions can be more severely affected by infectious diseases of the skin or heavy and pathologically significant parasitism. Neoplasia of the skin is probably more prevalent and worse in older horses, although many of the more serious skin tumors develop initially at a younger age. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Calidad de vida de los portadores de neoplasia de cabeza y de cuello en fase diagnóstica

    Directory of Open Access Journals (Sweden)

    Sebastião Benício da Costa Neto

    2005-01-01

    Full Text Available El interés por la calidad de vida (CV en la salud es consecuencia del desarrollo tecnológico que ha permitido mayor extensión de la vida a los portadores de enfermedades crónicas y degenerativas y ha exigido ajustes no sólo en las políticas de gestión y de disponibilidad de recursos, sino también en las decisiones clínicas, además de haber impuesto a la industria farmacéutica obediencia a reglas para el lanzamiento de drogas en el mercado. El objetivo de este estudio es analizar la CV de 190 portadores de neoplasia de cabeza y de cuello (NCP, en la región central del Brasil. Los datos han sido obtenidos por medio de la Escala Análogo- Visual de Calidad de Vida para Portadores de NCP, de Font y Costa Neto (Costa Neto, 2002, y de las escalas EORTC C-30 y EORTC H&N-35. En la fase diagnóstica (N=190 ha habido una pérdida de 23.4% a 31.4% en la CV general. Se ha concluido que las dimensiones Síntomas, Relaciones Familiares y Sociales y CV Global han sido las que han ejercido el más fuerte impacto en la CV. Se sugiere la inclusión de ítems destinados a la evaluación de las estrategias de afrontamiento en los instrumentos de CV, buscando, por ejemplo, su utilización en la rutina asistencial junto al enfermo y su familia.

  15. CALIDAD DE VIDA DE LOS PORTADORES DE NEOPLASIA DE CABEZA Y DE CUELLO EN FASE DIAGNÓSTICA

    Directory of Open Access Journals (Sweden)

    Tereza Cristina Cavalcanti Ferreira de Araujo

    2005-06-01

    Full Text Available El interés por la calidad de vida (CV en la salud es consecuencia del desarrollo tecnológico que ha permitido mayor extensión de la vida a los portadores de enfermedades crónicas y degenerativas y ha exigido ajustes no sólo en las políticas de gestión y de disponibilidad de recursos, sino también en las decisiones clínicas, además de haber impuesto a la industria farmacéutica obediencia a reglas para el lanzamiento de drogas en el mercado. El objetivo de este estudio es analizar la CV de 190 portadores de neoplasia de cabeza y de cuello (NCP, en la región central del Brasil. Los datos han sido obtenidos por medio de la Escala Análogo- Visual de Calidad de Vida para Portadores de NCP, de Font y Costa Neto (Costa Neto, 2002, y de las escalas EORTC C-30 y EORTC H&N-35. En la fase diagnóstica (N=190 ha habido una pérdida de 23.4% a 31.4% en la CV general. Se ha concluido que las dimensiones Síntomas, Relaciones Familiares y Sociales y CV Global han sido las que han ejercido el más fuerte impacto en la CV. Se sugiere la inclusión de ítems destinados a la evaluación de las estrategias de afrontamiento en los instrumentos de CV, buscando, por ejemplo, su utilización en la rutina asistencial junto al enfermo y su familia.

  16. Las insulinas

    OpenAIRE

    Manuel González Ortiz; Esperanza Martínez Abundis

    2001-01-01

    La insulina es una hormona secretada por elpáncreas participa en el metabolismo de loscarbohidratos, lípidos y proteínas. La produc-ción deficiente de insulina y/o la disminución enla respuesta de los tejidos y órganos periféricosa su acción constituyen las principales basesetiopatogénicas de la diabetes mellitus. Lainsulina se ha podido sintetizar para su usofarmacológico y forma parte importante dentrode las opciones terapéuticas vigentes para elmanejo de la diabetes mellitus. La presente r...

  17. Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia

    DEFF Research Database (Denmark)

    Mahmood, Badar; Damm, Morten Matthiesen Bach; Jensen, Thorbjørn Søren Rønn

    2016-01-01

    showed overexpression of subtype PDE4B (p = 0.002) and subtype PDE5A (p = 0.02) in colorectal neoplasia patients. Finally, immunohistochemistry for 7 PDE isozymes demonstrated the presence of all 7 isozymes, albeit with weak reactions, and with no differences in localization between colorectal neoplasia...

  18. Epidemiological evidence of cervical intraepithelial neoplasia without the presence of human papillomavirus

    NARCIS (Netherlands)

    Burger, MPM; Hollema, H; Pieters, WJLM; Schroder, FP; Quint, WGV

    1996-01-01

    The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (GIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in r

  19. Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

    NARCIS (Netherlands)

    Koeneman, M. M.; Kruse, A. J.; Kooreman, L. F S; zur Hausen, A.; Hopman, A. H N; Sep, S. J S; Van Gorp, T.; Slangen, B. F M; van Beekhuizen, H. J.; van de Sande, A. J M; Gerestein, C. G.; Nijman, H. W.; Kruitwagen, R. F P M

    2017-01-01

    The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia (

  20. Las Sinapsis

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Duque Parra

    1997-12-01

    Full Text Available

    Introducción

    El estudio del sistema nervioso considera entre múltiples conexiones, aquéllas de carácter bioquímico que se median a través de sustancias elaboradas por las neuronas y que reciben la denominación de neurotransmisores’, dichas sustancias se vierten en las zonas de resquicio neuromuscular, neuroneuronal o neuroglandular, para modificar las condiciones de membrana y permitir la continuidad de los potenciales de acción (por creación de nuevos potenciales en las células subsiguientes, de la neurona hacia el órgano blanco.

    La integridad de los diversos elementos de la “zona de unión funcional” o sinapsis, asegura la adecuada comunicación entre el sistema nervioso y la mayoría de los elementos restantes del organismo humano.

    Las alteraciones de los elementos de las sinapsis, conllevan a la génesis de estados variables fisiológicos y patológicos somáticos, psicosomáticos o psíquicos, inconsecuentes con el estado de homeostasis.

    Las moléculas que se vierten en las hendiduras sinápticas, sirven, por tanto, de transductoras para efectos elementales (como los reflejos y en las estrategias complejas (como los de la actividad intelectual.

    Antecedentes

    Ya desde los tiempos de Galeno, se sabía que los nervios eran los responsables de la rápida comunicación entre el cuerpo y el cerebro; el estudio de las sinapsis nos remonta de manera indirecta a
    1791, fecha en la que Luigi Galvani, descubrió en sus experimentos con ancas de ranas, que entre los eventos eléctricos y los ocurridos en los nervios, existía una relación evidente (28,37,45’, los experimentos de Galvani se han refinado con el paso del tiempo, en nuestro siglo por ejemplo, el desarrollo del osciloscopio de rayos catódicos combinado con un amplificador potente, ha permitido medir las débiles y variables corrientes bioeléctricas de los

  1. Perfil epidemiológico das neoplasias de glândulas salivares diagnosticadas em São Luís-MA Epidemiologic profile of salivary gland neoplasms diagnosed in São Luís-MA

    Directory of Open Access Journals (Sweden)

    Rafael Sereno Loiola

    2009-10-01

    Full Text Available INTRODUÇÃO E OBJETIVO: As neoplasias de glândulas salivares constituem um grupo de lesões, clínica e morfologicamente diverso, capaz de determinar importantes desafios diagnósticos e terapêuticos. O escopo do trabalho é determinar a frequência relativa e a distribuição das neoplasias de glândulas salivares diagnosticadas no Instituto Maranhense de Oncologia Aldenora Bello (IMOAB. MATERIAL E MÉTODOS: Realizou-se estudo retrospectivo dos casos de neoplasia de glândula salivar diagnosticados no IMOAB, no período de janeiro de 1997 a dezembro de 2007. Dados sobre sexo, idade e localização anatômica foram obtidos em prontuários médicos. Cortes histológicos foram avaliados sob microscopia de luz e os casos foram categorizados segundo a classificação da Organização Mundial da Saúde (OMS(4. Os dados coletados foram analisados por meio de estatística descritiva. RESULTADOS: Foram identificados 232 casos, dos quais 178 eram neoplasias benignas (76,7% e 54 (23,3%, malignas. Os três tipos histológicos mais frequentes foram: adenoma pleomórfico (59,5%, tumor de Warthin (13,8% e carcinoma adenoide cístico (6,9%. A maioria dos casos foi diagnosticada em pacientes do sexo feminino, com proporção homem:mulher de 1:1,3. As neoplasias benignas e malignas apresentaram picos de incidência na quarta e sétima décadas de vida, respectivamente. Com relação à localização anatômica, 154 casos (66,4% afetaram a parótida, 43 (18,5% acometeram a glândula submandibular e 35 (15,1% envolveram glândulas salivares menores. CONCLUSÃO: Em conjunto com outros estudos, os resultados da presente pesquisa sugerem discretas variações na frequência relativa e distribuição das neoplasias de glândulas salivares entre as populações do Brasil e de outras regiões do mundo.INTRODUCTION AND OBJECTIVE: The salivary gland neoplasms are a clinically and morphologically diverse group of lesions able to determine important diagnostic and

  2. Testicular neoplasia in undescended testes of cryptorchid boys-does surgical strategy have an impact on the risk of invasive testicular neoplasia?

    DEFF Research Database (Denmark)

    Cortes, Dina; Thorup, Jorgen; Petersen, Bodil Laub

    2004-01-01

    UNLABELLED: We investigated whether or not surgical strategy has an impact on the risk of invasive testicular neoplasia in cases of cryptorchidism. We made a database study of the incidence of testicular neoplasia at surgery for cryptorchidism in childhood, and evaluated if such abnormalities were...... other than cryptorchidism, or diagnosed abnormal karyotype, versus no case in the 1281 patients without these characteristics (Fisher's exact test, p ... (Fisher's exact test, p

  3. Neoplasia intra-epitelial cervical: diagnóstico e tratamento Cervical intraepithelial neoplasia: diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Sophie Françoise Mauricette Derchain

    2005-07-01

    Full Text Available O câncer do colo uterino é hoje doença passível de prevenção secundária. Os métodos de detecção das lesões precursoras e da infecção pelo papilomavírus humano, tais como a citologia oncológica e biologia molecular, são de uso mundialmente difundido. Entretanto, ainda há muita controvérsia em relação à aplicação destes métodos na prática ginecológica. Qual o melhor exame ou a melhor associação de exames que podem ser utilizados, com que intervalo e em quais mulheres permanecem questões que com freqüência geram ansiedade nos consultórios ou nas unidades de saúde. Por outro lado, uma vez detectada a infecção viral ou a neoplasia intra-epitelial cervical, o tratamento dessas mulheres ainda não é consensual e muitos fatores interferem na definição da conduta ótima. O tipo de infecção, gravidade da neoplasia intra-epitelial, tipo histológico encontrado, todos estes aspectos tendem a dificultar o planejamento terapêutico. Esta revisão tem como objetivo abordar, dentro do conhecimento atual e baseado nos consensos vigentes no país, vários aspectos relacionados ao rastreamento das lesões cervicais e as possíveis condutas terapêuticas vigentes.Cervical cancer is nowadays a disease amenable to secondary prevention. Methods for the detection of its precursor lesions and human papillomavirus infection, such as cervical cytology and molecular biology, achieved widespread use worldwide. However, there is still too much controversy regarding the use of these methods in gynecological practice. Which is the best examination or the best association of examinations, and the most adequate time intervals to proceed with screening, are still pending questions, generating anxiety in patients and doctors. On the other hand, the management of women who have been diagnosed with viral infection and/or cervical intraepithelial neoplasia is not yet consensual, and several factors may affect the clinical decision on how to

  4. Cyclooxygenase-2 Expression in Hamster and Human Pancreatic Neoplasia

    Directory of Open Access Journals (Sweden)

    Pamela L. Crowell

    2006-06-01

    Full Text Available Cyclooxygenase-2 (COX-2 has been implicated in the development of gastrointestinal malignancies. The aim of the present study was to determine COX-2 expression/activity throughout stages of experimental and human pancreatic neoplasia. COX-2 immunohistochemistry was performed in pancreata of hamsters subjected to the carcinogen N-nitrosobis-(2-oxopropylamine (BOP and in human pancreatic tumors. COX-2 activity was determined by prostaglandin E2 assay in tumor versus matched normal pancreatic tissues. The activity of the COX inhibitor sulindac was tested in the PC-1 hamster pancreatic cancer model. COX-2 expression was elevated in all pancreatic intraepithelial neoplasias (PanINs and adenocarcinomas. In BOP-treated hamsters, there were significant progressive elevations in COX-2 expression throughout pancreatic tumorigenesis. In human samples, peak COX-2 expression occurred in PanIN2 lesions and remained moderately elevated in PanIN3 and adenocarcinoma tissues. COX-2 activity was significantly elevated in hamster and human pancreatic cancers compared to pair-matched normal pancreas. Furthermore, hamster pancreatic tumor engraftment/formation in the PC-1 hamster pancreatic cancer model was reduced 4.9-fold by oral administration of sulindac. Increased COX-2 expression is an early event in pancreatic carcinogeneses. The BOP-induced hamster carcinogenesis model is a representative model used to study the role of COX-2 in well-differentiated pancreatic tumorigenesis. COX inhibitors may have a role in preventing tumor engraftment/formation.

  5. Analysis of digitized cervical images to detect cervical neoplasia

    Science.gov (United States)

    Ferris, Daron G.

    2004-05-01

    Cervical cancer is the second most common malignancy in women worldwide. If diagnosed in the premalignant stage, cure is invariably assured. Although the Papanicolaou (Pap) smear has significantly reduced the incidence of cervical cancer where implemented, the test is only moderately sensitive, highly subjective and skilled-labor intensive. Newer optical screening tests (cervicography, direct visual inspection and speculoscopy), including fluorescent and reflective spectroscopy, are fraught with certain weaknesses. Yet, the integration of optical probes for the detection and discrimination of cervical neoplasia with automated image analysis methods may provide an effective screening tool for early detection of cervical cancer, particularly in resource poor nations. Investigative studies are needed to validate the potential for automated classification and recognition algorithms. By applying image analysis techniques for registration, segmentation, pattern recognition, and classification, cervical neoplasia may be reliably discriminated from normal epithelium. The National Cancer Institute (NCI), in cooperation with the National Library of Medicine (NLM), has embarked on a program to begin this and other similar investigative studies.

  6. A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus.

    Directory of Open Access Journals (Sweden)

    Kit Curtius

    2015-05-01

    Full Text Available Barrett's esophagus (BE patients are routinely screened for high grade dysplasia (HGD and esophageal adenocarcinoma (EAC through endoscopic screening, during which multiple esophageal tissue samples are removed for histological analysis. We propose a computational method called the multistage clonal expansion for EAC (MSCE-EAC screening model that is used for screening BE patients in silico to evaluate the effects of biopsy sampling, diagnostic sensitivity, and treatment on disease burden. Our framework seamlessly integrates relevant cell-level processes during EAC development with a spatial screening process to provide a clinically relevant model for detecting dysplastic and malignant clones within the crypt-structured BE tissue. With this computational approach, we retain spatio-temporal information about small, unobserved tissue lesions in BE that may remain undetected during biopsy-based screening but could be detected with high-resolution imaging. This allows evaluation of the efficacy and sensitivity of current screening protocols to detect neoplasia (dysplasia and early preclinical EAC in the esophageal lining. We demonstrate the clinical utility of this model by predicting three important clinical outcomes: (1 the probability that small cancers are missed during biopsy-based screening, (2 the potential gains in neoplasia detection probabilities if screening occurred via high-resolution tomographic imaging, and (3 the efficacy of ablative treatments that result in the curative depletion of metaplastic and neoplastic cell populations in BE in terms of the long-term impact on reducing EAC incidence.

  7. Spermatozoa-like cell invaders (nuclear vlimata) in human neoplasia.

    Science.gov (United States)

    Logothetou-Rella, H

    1993-07-01

    Spermatozoa-like cells (nuclear vlimata) have been identified in malignant cell cultures and embryonic cells, also common in the cytology and histology of all types of human neoplasia even after chemotherapy. A new mechanism of invasion of malignant cells has been described, according to which neoplastic cells behave and function as parasites using host-cells to divide, survive and eventually produce nuclear vlimata (bullets). Nuclear vlimata are the end cell products of incomplete, unequal, assymetrical division of neoplastic cells. The nuclear vlima exhibits similar morphology to spermatozoa and virus (head with, or without, tail) and invades the cytoplasm and/or nucleus of surrounding host-cells by a similar mechanism to sperm-oocyte interaction (fertilization) or viral cell infection, in the events of nuclear vlima-->tumor-->nuclear vlima-->tumor. The nuclear vlima head contains and transfers DNA, and when incorporated into the host-nucleus is indistinguishable from nucleoli and when in the cytoplasm is similar to sperm pronucleus, observed after sperm penetration of the oocyte. Function of nuclear vlimata is directly dependent on the specific extracellular matrix produced by malignant cells, consisting of glycosaminoglycans-protease-membranes. This mechanism of invasion constitutes the link of all scientific information concerning human neoplasia.

  8. Synchronous high-risk melanoma and lymphoid neoplasia.

    LENUS (Irish Health Repository)

    Cahill, R A

    2012-02-03

    Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin\\'s lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatment and progress of three patients who developed advanced melanoma concurrently with a lymphoid neoplasm (one NHL, two CLLs), in order to illustrate their association, discuss common aetiological factors and examine possible therapeutic options. As it is the melanoma rather than the lymphoid neoplasm that represents the bigger threat to overall survival, initial treatment should be targeted towards this cancer. However, because of the interplay between the diseases and the possible side-effects of the various treatments, the choice of adjuvant therapy requires careful consideration. Immunosuppression associated with chemotherapy may permit a more aggressive course for the melanoma, while locoregional radiotherapy is contraindicated following lymph node dissections. As immunotherapy is of benefit in the treatment of melanoma and has also been recently shown to be effective in the management of lymphoid neoplasia, we instituted interferon-alpha as adjuvant therapy for these patients, thereby utilizing a single agent to treat the dual pathologies. The three patients have now been followed-up for 6 months without evidence of disease recurrence or progression.

  9. SENSITIVITY OF IMPRESSION CYTOLOGY IN DIAGNOSING OCULAR SURFACE SQUAMOUS NEOPLASIA

    Directory of Open Access Journals (Sweden)

    Malleswari

    2015-10-01

    Full Text Available OSSN describes a spectrum of neoplastic lesions, originating from squamous epithelium ranging from simple dysplasia to invasive squamous cell carcinoma (SCC, involving the conjunctiva, limbus and the cornea. Impression cytology refers to the technique by which superficial layers of the ocular surface are removed through application of cellulose acetate filter material onto the ocular surface AIM: To Assess the Sensitivity of Impression Cytology in the Diagnosis of Ocular Surface Squamous Neoplasia Using Millipore Filter Paper. MATERIALS AND METHODS: This is a Prospective Observational and Interventional Study conducted at Sarojini Devi Eye Hospital and Gandhi Medical College/Hospital, Hyderabad. Study was conducted from July2013 to Feb2015 and included 50patients presenting with conjunctival mass at the limbus or on the conjunctiva Hospital ethics committee approval was obtained No financials involved in the study. RESULTS: A total of 50Excision biopsies of 50patients suspected for OSSN were performed there were 40 males and 10females Excision biopsy confirmed the Impression Cytology results in 44 cases. In 6 cases there was poor correlation among which 4cases showed mild dysplasia in Impression Cytology while HPE showed Invasive Squamous cell carcinoma in 2cases few dysplastic cells were noted in Impression cytology but HPE showed Carcinoma in situ. CONCLUSION: This study shows that Impression Cytology has a promising role in diagnosing Ocular Surface Squamous Neoplasia for its high positive predictive accuracy (95.65% compared with tissue histology.

  10. Levels of oxidative damage and lipid peroxidation in thyroid neoplasia.

    LENUS (Irish Health Repository)

    Young, Orla

    2012-02-01

    BACKGROUND: This study assessed the presence of oxidative damage and lipid peroxidation in thyroid neoplasia. METHODS: Using tissue microarrays and immunohistochemistry, we assessed levels of DNA damage (8-oxo-dG) and lipid peroxidation (4-HNE) in 71 follicular thyroid adenoma (FTA), 45 papillary thyroid carcinoma (PTC), and 17 follicular thyroid carcinoma (FTC) and matched normal thyroid tissue. RESULTS: Cytoplasmic 8-oxo-dG and 4-HNE expression was significantly higher in FTA, FTC, and PTC tissue compared to matched normal tissue (all p values < .001). Similarly, elevated nuclear levels of 8-oxo-dG were seen in all in FTA, FTC, and PTC tissue compared to matched normal (p values < .07, < .001, < .001, respectively). In contrast, a higher level of 4-HNE expression was detected in normal thyroid tissue compared with matched tumor tissue (p < .001 for all groups). Comparing all 3 groups, 4-HNE levels were higher than 8-oxo-dG levels (p < .001 for all groups) except that cytoplasmic levels of 8-oxo-dG were higher than 4-HNE in all (p < .001). These results were independent of proliferation status. CONCLUSION: High levels of DNA damage and lipid peroxidation in benign and malignant thyroid neoplasia indicates this damage is an early event that may influence disease progression.

  11. Scrotal neoplasia: would truck drivers be at greater risk?

    Directory of Open Access Journals (Sweden)

    Daniel Seabra

    2007-08-01

    Full Text Available OBJECTIVE: To analyze how scrotal neoplasias have been managed during the past decade and to question possible factors or professions associated to its presence. MATERIALS AND METHODS: We retrospectively evaluated every case reported from 1995 to 2005 at our hospital. We described the clinical scenario, complementary exams, treatments and outcomes. We also tried to verify if there was any risk, predisposing factors or professions that would explain the cancer origin. RESULTS: Six cases were reviewed. Out of these, three patients were truck drivers. Five of them showed restricted lesions without inguinal lymph nodes enlargement. Histologically, six patients presented squamous carcinoma, with two of them having the verrucous type. The median age of patients was 52 years old (31 to 89. The five patients who are still alive had their lesions completely removed with safety margin and primary closure. CONCLUSIONS: We have noticed that the scrotal carcinoma behavior is similar to that of the penis, where removal of the lesion and study of the regional lymph nodes help to increase the patient survival rate. The outstanding fact was that three out of six patients were truck drivers, raising the hypothesis that such profession, maybe due to the contact or attrition with the diesel exhaust expelled by the engine or to sexual promiscuity, would imply in a larger risk of developing this rare neoplasia.

  12. Outcomes from a prospective trial of endoscopic radiofrequency ablation of early squamous cell neoplasia of the esophagus

    NARCIS (Netherlands)

    J.J.G.H.M. Bergman; Y.M. Zhang; S. He; B. Weusten; L. Xue; D.E. Fleischer; N. Lu; S.M. Dawsey; G.Q. Wang

    2011-01-01

    Background: Radiofrequency ablation (RFA) is safe and effective for eradicating neoplasia in Barrett's esophagus. Objective: To evaluate RFA for eradicating early esophageal squamous cell neoplasia (ESCN) defined as moderate-grade squamous intraepithelial neoplasia (MGIN) and high-grade squamous int

  13. Quantitative attenuation analysis for identification of early Barrett's neoplasia in volumetric laser endomicroscopy.

    Science.gov (United States)

    Swager, Anne-Fre; Faber, Dirk J; de Bruin, Daniel M; Weusten, Bas L; Meijer, Sybren L; Bergman, Jacques J; Curvers, Wouter L; van Leeuwen, Ton G

    2017-08-01

    Early neoplasia in Barrett’s esophagus (BE) is difficult to detect. Volumetric laser endomicroscopy (VLE) incorporates optical coherence tomography, providing a circumferential scan of the esophageal wall layers. The attenuation coefficient (μVLE) quantifies decay of detected backscattered light versus depth, and could potentially improve BE neoplasia detection. The aim is to investigate feasibility of μVLE for identification of early BE neoplasia. In vivo and ex vivo VLE scans with histological correlation from BE patients ± neoplasia were used. Quantification by μVLE was performed manually on areas of interest (AoIs) to differentiate neoplasia from nondysplastic (ND)BE. From ex vivo VLE scans from 16 patients (13 with neoplasia), 68 AoIs were analyzed. Median μVLE values (mm−1) were 3.7 [2.1 to 4.4 interquartile range (IQR)] for NDBE and 4.0 (2.5 to 4.9 IQR) for neoplasia, not statistically different (p=0.82). Fourteen in vivo scans were used: nine from neoplastic and five from NDBE patients. Median μVLE values were 1.8 (1.5 to 2.6 IQR) for NDBE and 2.1 (1.9 to 2.6 IQR) for neoplasia, with no statistically significant difference (p=0.37). In conclusion, there was no significant difference in μVLE values in VLE scans from early neoplasia versus NDBE. Future studies with a larger sample size should explore other quantitative methods for detection of neoplasia during BE surveillance.

  14. Metástasis en hueso maxilar superior de adenocarcinoma de esófago: presentación de un caso clínico

    OpenAIRE

    Sánchez Jiménez, Juan; Acebal Blanco, Faustino; Arévalo Arévalo, Rafael; Molina Martínez, Manuel

    2005-01-01

    Las metástasis en cavidad oral son lesiones raras que representan aproximadamente el 1% de todas las neoplasias malignas de cavidad oral. Las metástasis orales se localizan en un 80-90% en mandíbula, siendo mas raras en maxilar superior. Las metástasis en tejidos blandos de boca son raras, y es encía donde con mayor frecuencia se localizan las metástasis en tejidos blandos en boca. Los tumores primarios que metastatizan a boca son los más frecuentes pulmón, mama y riñón. ...

  15. Cervical squamous and glandular intraepithelial neoplasia: identification and current management approaches Neoplasia intraepitelial cervical escamosa y glandular: identificación y estrategias de manejo

    Directory of Open Access Journals (Sweden)

    V Cecil Wright

    2003-01-01

    Full Text Available Certain types of human papillomaviruses (HPV are associated with squamous intraepithelial lesions and cancer and these are termed high-risk. HPV type 16 is detected in approximately half of the high-grade squamous intraepithelial lesions and cancer. Because of the high rate of spontaneous regression of low-grade squamous lesions, follow-up by cytology, colposcopy and possible biopsy appears preferable. Due to the higher rate of progression to malignancy of the high-grade lesions conservative treatment is recommended. One of the most common reasons for persistence relates to the human immunodeficiency virus. Adenocarcinoma in situ is an uncommon disorder and not well identified by cytologic sampling or colposcopic inspection. The diagnosis is made by cone biopsy, the specimen having negative margins for disease. Hysterectomy is the treatment procedure of choice unless fertility is an issue. Excisional methods (particularly electrosurgical loop can interfere with accurate histological interpretation in some cases of both squamous disease and adenocarcinoma in situ.Ciertos tipos de virus del papiloma humano (VPH, denominados de alto riesgo, están asociados con lesiones escamosas intraepiteliales y cáncer invasor. El VPH tipo 16 es detectado en aproximadamente la mitad de las lesiones escamosas intraepiteliales de alto grado y cáncer. Sin embargo, existe una elevada proporción de regresión espontánea en lesiones escamosas de bajo grado, por lo que para su monitoreo es preferible la utilización de citología, colposcopía y biopsia. Asimismo, debido a la elevada tasa de progresión a malignidad de lesiones de alto grado se recomienda un tratamiento conservador. Una de las razones comunes relacionadas con la persistencia de infección por el VPH es el virus de inmunodeficiencia humana. Por otra parte, el adenocarcinoma in situ es un trastorno raro, no bien identificado en muestras citológicas o de inspección colposcópica; el diagnóstico se

  16. Primary osteosarcoma of the thyroid gland: report of a rare neoplasm Osteossarcoma primário da glândula tireoide: relato de uma neoplasia rara

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2013-02-01

    Full Text Available Primary mesenchymal tumors of the thyroid gland are extremely rare. The authors report a case of primary thyroid osteosarcoma in a male patient presenting a tumoral mass in the neck. CT scan demonstrated a large tumor in the right thyroid lobe with areas of calcification. The surgical specimen consisted of a hard brown-gray tumor, measuring 13 × 11 × 7.5 cm. Microscopy revealed a high-grade malignant neoplasm composed of polygonal cells of intermediate size, chondroid pattern in some areas and osteoid formation. The process was immunonegative for AE1/AE3, glial fibrillary acidic protein (GFAP, epithelial membrane antigen (EMA, p53 and thyroid transcription factor-1 (TTF-1, and immunopositive for CD99 and S100. Thus the diagnosis of primary osteosarcoma of the thyroid gland was established.Tumores mesenquimais da glândula tireoide são extremamente raros. Os autores relatam um caso de osteossarcoma primário de tireoide em um paciente masculino que apresentou massa tumoral na região cervical. A tomografia computadorizada demonstrou um grande tumor no lobo tireoideano direito, com zonas de calcificação. A peça cirúrgica consistia de um tumor marrom-acinzentado e firme, medindo 13 × 11 × 7,5 cm. À microscopia, foi encontrada neoplasia maligna de alto grau composta por células poligonais de tamanho intermédio, com um padrão condroide em algumas áreas e formação de osteoide. O processo revelou imunoexpressão negativa para AE1/AE3, proteína glial fibrilar ácida (GFAP, antígeno da membrana epitelial (EMA, p53 e fator de transcrição da tireoide (TTF-1 e imunopositividade para CD99 e S100. O diagnóstico de osteossarcoma primário da glândula tireoide foi, então, estabelecido.

  17. Las incumbencias

    Directory of Open Access Journals (Sweden)

    Emilio Fermín Mignone

    2013-05-01

    Full Text Available Desde mediados de la década de 1970 se desarrolló en la Argentina un sistema dirigido a establecer las denominadas incumbencias de las profesiones universitarias, que ha alcanzado notable dimensión. Sin embargo, no conozco hasta el presente un análisis pormenorizado de su evolución ni de sus fundamentos legales; ni una reflexión acerca de sus propósitos, ventajas e inconvenientes. El propósito de este trabajo es iniciar dicho examen para contribuir con una propuesta racional al desenvolvimiento de una política universitaria orientada hacia el acrecentamiento de la autonomía de los establecimientos, la distinción entre el título académico y la habilitación profesional, la desregulación, en la medida de lo razonable, del ejercicio de las profesiones y la evaluación periódica de la calidad de la educación superior, a fin de procurar su excelencia, pertinencia, eficiencia y equidad

  18. Microtopographic Inspection and Fractal Analysis of Skin Neoplasia

    Science.gov (United States)

    Costa, Manuel F. M.; Hipolito, Alberto Valencia; Gutierrez, Gustavo Fidel; Chanona, Jorge; Gallegos, Eva Ramón

    2008-04-01

    ) corresponding to some neoplasia is higher (1.334+/-0.072) than those for healthy skin (1.091+/-0.082). A significant difference between the fractal dimensions of neoplasia and healhty skin (>0.001) was registered. The FD of microtopography maps (FDm) can also distinguish between healthy and malignant tissue in general (2.277+/-0.070 to 2.309+/-0.040), but not discriminate the different types of skin neoplasias. The combination of the rugometric evaluation and fractal geometry characterization provides valuable information about the malignity of skin lesions and type of lesion.

  19. Estudio anatomopatológico de los tumores de las glándulas salivares

    OpenAIRE

    2004-01-01

    Hemos estudiado, de forma retrospectiva, las características epidemiológicas, morfológicas e inmunohistoquímicas de 400 tumores de las glándulas salivares. La clasificación diagnóstica utilizada ha sido la de Ellis y Auclair (AFIP 1995). Los tumores de las glándulas salivares de nuestras serie son neoplasias que afectan con mayor frecuencia a pacientes entre 30 y 60 años de edad; en los pacientes con tumores benignos, la edad es significativamente menor que los que presentan turmores malignos...

  20. Las necesidades educativas especiales de los niños con tumores intracraneales

    OpenAIRE

    Grau Rubio, Claudia

    2000-01-01

    Los tumores del sistema nervioso central (S.N.C.) son el segundo tipo de neoplasias más usuales en la infancia, después de las leucemias, y constituyen uno de los retos más importantes, tanto para los médicos, como para los psicólogos, pedagogos y maestros, en su tarea de mejorar o compensar las secuelas neurológicas derivadas de la enfermedad y de los tratamientos. En la práctica las secuelas son el precio que un niño con tumor intracraneal debe pagar por vivir, y la meta futura es intentar ...

  1. A series of 64 cases of pancreatic cystic neoplasia from an institutional study of China

    Institute of Scientific and Technical Information of China (English)

    Yuan Ji; Wen-Hui Lou; Da-Yong Jin; Tian-Tao Kuang; Meng-Su Zeng; Yun-Shan Tan; Hai-Ying Zeng; Akesu Sujie; Xiong-Zeng Zhu

    2006-01-01

    AIM: To recognize cystic neoplasia of the pancreas and thus to identify a panel of curable diseases. METHODS: Sixty-four cases of cystic neoplasia of the pancreas, including 28 cases of intraductal papillary mucinous neoplasia (IPMN), 12 Cases of serous cystic neoplasia (SCN), 11 cases of mucinous cystic neoplasia (MCN), 11 cases of solid pseudo-papillary neoplasia (SPN), and 2 cases of solid tumor with cystic degeneration were examined immunohistochemically for their expression of MUC1, MUC2, MUC4, MUC5AC, and MUC6, as well as other related antigens.RESULTS: Adenoma type of IPMN and borderline lesions exhibited high expressions of MUC2, and MUCSAC. Tn contrast, IPMN with invasive carcinoma component showed MUC1 immunoreactivity. SCN was mainly positive for MUC1 and MUC6, while negative for MUC2, MUC4 and MUC5AC. Noninvasive MCN, regardless of its cellular atypia degree, was positive for MUC5AC and negative for MUC1. MUC1 expression was only observed in patients with an invasive component. No mucin expression was found in SPN.CONCLUSION: Mucin profile may, in conjunction with histologic study, provide important information on tumor types and patient treatment of cystic neoplasia of the pancreas.

  2. Uterine cervical neoplasia prevention in Parque Indigena do Xingu.

    Science.gov (United States)

    Speck, N M de Góis; Pereira, E R; Schaper, M; Tso, F K; de Freitas, V G; Ribalta, J C L

    2009-01-01

    Results of preventive health measures, diagnosis and treatment applied to Parque Indigena do Xingu native women were studied. Thirty-seven cases of uterine cervical intraepithelial lesions and invasive neoplasias were treated in the local villages without referral to an advanced medical center. LEEPs were carried out in 32 women, three cold knife conizations, one vaginal hysterectomy and one Wertheim Meigs procedure. Results of 53.1% of LEEP surgical procedures did not have margin involvement by the lesions. Bleeding complications were seen in 15.6%. Regular follow-up with two or three cytologic and colposcopic tests in 32 women was carried out. All cases were negative for lesions. Five women were not followed-up due mainly to logistical reasons. Health endeavors adopted in the period 2005-2007 brought about a significant reduction of precursor lesions in this native aboriginal population without screening resources.

  3. Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1

    Directory of Open Access Journals (Sweden)

    Grzegorz Piecha

    2010-01-01

    Full Text Available Primary hyperparathyroidism may occur as a part of an inherited syndrome in a combination with pancreatic endocrine tumours and/or pituitary adenoma, which is classified as Multiple Endocrine Neoplasia type 1 (MEN-1. This syndrome is caused by a germline mutation in MEN-1 gene encoding a tumour-suppressor protein, menin. Primary hyperparathyroidism is the most frequent clinical presentation of MEN-1, which usually appears in the second decade of life as an asymptomatic hypercalcemia and progresses through the next decades. The most frequent clinical presentation of MEN-1-associated primary hyperparathyroidism is bone demineralisation and recurrent kidney stones rarely followed by chronic kidney disease. The aim of this paper is to present the pathomechanism, screening procedures, diagnosis, and management of primary hyperparathyroidism in the MEN-1 syndrome. It also summarises the recent advances in the pharmacological therapy with a new group of drugs—calcimimetics.

  4. Treatment of cervical intraepithelial neoplasia in Denmark 1991 to 2007

    DEFF Research Database (Denmark)

    Barken, Sidsel Svennekjær

    2010-01-01

    Abstract: Objectives: The number of invasive cervical cancers peaked in Denmark in 1966 with 963 cases. Cervical cancer is prevented by treatment of screen-detected cervical intraepithelial neoplasia (CIN). We assessed the trend in CIN treatments in Denmark. Material and Methods: From highly...... the data using the unique Danish identification numbers, and excluded all duplicate registrations. We excluded all destructive therapies and hysterectomies for which no CIN or cervical cancer diagnosis was found in the period from 3 months before to 1 month after the treatment date. We age......-standardized the number of cervical treatments using Danish women in 2007 as standard population. Results: The preliminary analysis shows that the number of treatments increased from about 6,000 in 1991 to about 8,200 in 2007, most noticeably due to an increase of about 2,600 in the number of conisations (Figure 1...

  5. Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade

    Science.gov (United States)

    Carbinatto, Fernanda M.; Inada, Natalia M.; Lombardi, Welington; da Silva, Eduardo V.; Belotto, Renata; Kurachi, Cristina; Bagnato, Vanderlei S.

    2016-02-01

    Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer and associated with human papillomavirus (HPV) infection. Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors. PDT is based on the accumulation of a photosensitizer in target cells that will generate cytotoxic reactive oxygen species upon illumination, inducing the death of abnormal tissue and PDT with less damaging to normal tissues than surgery, radiation, or chemotherapy and seems to be a promising alternative procedure for CIN treatment. The CIN high grades (II and III) presents potential indications for PDT due the success of PDT for CIN low grade treatment. The patients with CIN high grade that were treated with new clinic protocol shows lesion regression to CIN low grade 60 days after the treatment. The new clinical protocol using for treatment of CIN high grade shows great potential to become a public health technique.

  6. Psychological effects of diagnosis and treatment of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Frederiksen, Maria Eiholm; Njor, Sisse; Lynge, Elsebeth

    2015-01-01

    BACKGROUND: Treatment of cervical intraepithelial neoplasia (CIN) is a common minor surgical procedure to prevent uterine cervical cancer. However, news of an abnormality detected at screening for cancer might cause the woman to worry. OBJECTIVES: To investigate the psychological consequences...... psychological outcomes in women with a histological diagnosis or treatment of CIN, and in women having an outcome other than CIN at cervical screening. DATA COLLECTION AND ANALYSIS: We abstracted the data using a pre-specified list of study characteristics and measured outcomes. For studies not reporting...... statistical testing, we estimated the statistical significance of the differences between the compared groups using unpaired t tests. MAIN RESULTS: From 5099 retrieved abstracts, 16 studies were included. Diagnosis and treatment of CIN were associated with worse psychological outcomes than normal cytology...

  7. Neoplasia endócrina múltipla tipo 2

    OpenAIRE

    Maia, Ana Luiza Silva; Gross, Jorge Luiz; Punãles, Márcia Khaled

    2005-01-01

    O termo neoplasia endócrina múltipla tipo 2 (NEM 2) foi sugerido em 1968, por Steiner e cols., para diferenciar a síndrome clínica caracterizada pela presença de carcinoma medular de tireóide (CMT), feocromocitoma e hiperparatireoidismo, então denominada síndrome de Sipple, da síndrome de Wermer ou NEM tipo 1, que acomete as glândulas paratireóides, pâncreas e hipófise. Sizemore e cols. (1974) complementaram a diferenciação através da classificação da NEM 2 em 2 subgupos: pacientes com CMT, f...

  8. Current Chemotherapeutic Management of Patients with Gestational Trophoblastic Neoplasia

    Directory of Open Access Journals (Sweden)

    Taymaa May

    2011-01-01

    Full Text Available Gestational trophoblastic neoplasia (GTN describes a heterogeneous group of interrelated lesions that arise from abnormal proliferation of placental trophoblasts. GTN lesions are histologically distinct, malignant lesions that include invasive hydatidiform mole, choriocarcinoma, placental site trophoblastic tumor (PSTT and epithelioid trophoblastic tumor (ETT. GTN tumors are generally highly responsive to chemotherapy. Early stage GTN disease is often cured with single-agent chemotherapy. In contrast, advanced stage disease requires multiagent combination chemotherapeutic regimens to achieve a cure. Various adjuvant surgical procedures can be helpful to treat women with GTN. Patients require careful followup after completing treatment and recurrent disease should be aggressively managed. Women with a history of GTN are at increased risk of subsequent GTN, hence future pregnancies require careful monitoring to ensure normal gestational development. This article will review the workup, management and followup of women with all stages of GTN as well as with recurrent disease.

  9. Gastroenteropancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

    Energy Technology Data Exchange (ETDEWEB)

    Tonelli, Francesco, E-mail: f.tonelli@dfc.unifi.it; Giudici, Francesco [Department of Clinical Physiopathology, Surgical Unit, Medical School, University of Florence, Largo Brambilla n° 3, Florence 50134 (Italy); Giusti, Francesca; Brandi, Maria Luisa [Department of Internal Medicine, Medical School and Regional Centre for Hereditary Endocrine Tumors, University of Florence, Largo Brambilla n° 3, Florence 50134 (Italy)

    2012-05-07

    We reviewed the literature about entero-pancreatic neuroendocrine tumors in Multiple Endocrine Neoplasia type 1 syndrome (MEN1) to clarify their demographic features, localization imaging, practice, and appropriate therapeutical strategies, analyzing the current approach to entero-pancreatic neuroendocrine tumors in MEN1. Despite the fact that hyperparathyroidism is usually the first manifestation of MEN1, the penetrance of these tumors is similar. They are characterized by multiplicity of lesions, variable expression of the tumors, and propensity for malignant degeneration. Both the histological type and the size of MEN1 neuroendocrine tumors correlate with malignancy. Monitoring of pancreatic peptides and use of imaging exams allow early diagnosis and prompt surgical treatment, resulting in prevention of metastatic disease and improvement of long-term survival. Surgery is often the treatment of choice for MEN1-neuroendocrine tumors. The rationale for surgical approach is to curtail malignant progression of the disease, and to cure the associated biochemical syndrome, should it be present.

  10. A Metastatic Ovarian Angiosarcoma Mimicking Hematologic Neoplasia at Diagnosis

    Directory of Open Access Journals (Sweden)

    Rafael Dezen Gaiolla

    2014-04-01

    Full Text Available Angiosarcomas are rare aggressive neoplasms of vascular endothelial origin with a high metastatic rate and poor prognosis. Involvement of the bone marrow by the angiosarcoma is exceedingly uncommon, and there have only been a few cases reported in the literature to date. Clinical manifestations and common laboratory findings of bone marrow involvement can mimic other more common bone marrow-replacing neoplasias such as lymphomas and acute leukemia. A definitive diagnosis is difficult to make from cytologic material, probably due to an associated bone marrow fibrosis, and requires bone marrow trephine biopsy with an immunohistochemical profile. Here we had the opportunity to study a case of metastatic angiosarcoma with positive cytologic findings and an unusual presentation that challenged its primary diagnosis.

  11. Anterior Segment Imaging in Ocular Surface Squamous Neoplasia

    Directory of Open Access Journals (Sweden)

    Sally S. Ong

    2016-01-01

    Full Text Available Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN is diagnosed and monitored. Ultrasound biomicroscopy (UBM has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings. Although there are limitations to each of these imaging modalities, they can be useful adjunctive tools in the diagnosis of OSSN and could greatly assist the clinician in the management of OSSN patients. Nevertheless, anterior segment imaging has not replaced histopathology’s role as the gold standard in confirming diagnosis.

  12. Optical molecular imaging for detection of Barrett's-associated neoplasia

    Institute of Scientific and Technical Information of China (English)

    Nadhi Thekkek; Sharmila Anandasabapathy; Rebecca Richards-Kortum

    2011-01-01

    Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each.

  13. A Metastatic Ovarian Angiosarcoma Mimicking Hematologic Neoplasia at Diagnosis

    Science.gov (United States)

    Gaiolla, Rafael Dezen; Duarte, Ívison Xavier; Bacchi, Carlos Eduardo; Paiva, Carlos Eduardo

    2014-01-01

    Angiosarcomas are rare aggressive neoplasms of vascular endothelial origin with a high metastatic rate and poor prognosis. Involvement of the bone marrow by the angiosarcoma is exceedingly uncommon, and there have only been a few cases reported in the literature to date. Clinical manifestations and common laboratory findings of bone marrow involvement can mimic other more common bone marrow-replacing neoplasias such as lymphomas and acute leukemia. A definitive diagnosis is difficult to make from cytologic material, probably due to an associated bone marrow fibrosis, and requires bone marrow trephine biopsy with an immunohistochemical profile. Here we had the opportunity to study a case of metastatic angiosarcoma with positive cytologic findings and an unusual presentation that challenged its primary diagnosis. PMID:24847252

  14. Las denominaciones de las ocupaciones

    Directory of Open Access Journals (Sweden)

    Jesus Emilio Castañeda

    1990-04-01

    Full Text Available RESUMEN El propósito de este artículo, es mostrar al lector la forma como en nuestro ámbito existen diversos factores que han permitido la proliferación de maneras de llamar las ocupaciones. Aspectos regionales, la tradición, clases de organización, situaciones románticas, adjetivización de los cargos, peyorización  son entre otras razones que han generado  la creación de serie de sinónimos, de las ocupaciones, objeto de estudio de la sociologia del trabajo y de la administración de los recursos humanos.

  15. Las emociones y las TIC

    OpenAIRE

    Enríquez, Silvia Cecilia

    2014-01-01

    Tal vez este pueda resultar un tema sorprendente y, sin embargo, hay abundante bibliografía al respecto. Es posible que no nos lo hayamos planteado nunca, pero nuestra reacción ante el empleo de las TIC es determinante a la hora de medir los resultados que logremos en el aprendizaje que debemos hacer para poder incorporarlas a nuestra tarea. Docentes en Línea

  16. Endometrial Intraepithelial Neoplasia (EIN In An Endometrial Polyp

    Directory of Open Access Journals (Sweden)

    Devic Ana

    2015-12-01

    Full Text Available Endometrial intraepithelial neoplasia (EIN is a monoclonal neoplastic cell proliferation of the endometrium associated with a significantly increased risk of endometrioid endometrial adenocarcinoma. We herein present the case of a 58-year-old female patient who underwent a hysterectomy with bilateral salpingo-oophorectomy because of the existence of endometrial intraepithelial neoplasia in an endometrial polyp. The patient had irregular uterine bleeding, which lasted 10 days. An endometrial polyp was diagnosed by ultrasound examination. The polyp was located in the isthmus of the uterus, on the back wall, and measured 32 mm × 25 mm. The patient underwent fractional dilation and curettage, and the specimens were subjected to a histopathological examination. The histopathological findings were EIN, endometrioid type, a focus of which was found within the endometrial polyps, as well as the endometrial polyp and proliferative endometrium. The endocervical tissue was normal. Given the age of the patient and the histopathological findings, she underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. The final histopathological findings were EIN, endometrioid type with a focus found within the endometrial polyp; endometrial polyp; simple hyperplasia; chronic inflammation of the uterine cervix; hyperkeratosis of the cervical squamous epithelium; and cervicitis chronica. There was also hydrosalpinx of the left fallopian tube, and cystic follicles in the left ovary. There was no significant morphological change in the right ovary or fallopian tube. The surgical and postoperative course were normal. The patient was sent home on the fifth postoperative day in good general condition. A check-up performed one month after surgery showed normal findings.

  17. Viral-type orchitis: a potential mimic of testicular neoplasia.

    Science.gov (United States)

    Braaten, Kristina M; Young, Robert H; Ferry, Judith A

    2009-10-01

    Orchitis of viral or presumed viral etiology is an uncommon cause of testicular pain or enlargement. Rarely orchitis is clinically or radiographically suggestive of neoplasia, resulting in a testicular biopsy or orchiectomy being performed. Between 1978 and 2004, 10 cases submitted in consultation were diagnosed as orchitis at the Massachusetts General Hospital. The patients were from 18 to 37 years of age and presented with testicular enlargement or a mass, pain, or both. Radiographic studies were suspicious for a neoplasm in all 5 cases in which results were available. The patients underwent testicular biopsy (2 cases), orchiectomy (6 cases), biopsy immediately followed by orchiectomy (1 case), or biopsy followed by orchiectomy 3 weeks later (1 case). The cases were submitted with diagnoses that included intratubular seminoma, intratubular germ cell neoplasia, unspecified, Sertoli cell hyperplasia, myeloid sarcoma, and lymphoma. Microscopic examination revealed preservation of the architecture of the testicular parenchyma, typically with hemorrhage and edema, with patchy inflammation in the form of a lymphohistiocytic infiltrate within seminiferous tubules and also between tubules. The intratubular infiltrate usually predominated. Immunohistochemical studies, performed in 7 cases showed a mixture of CD68+ histiocytes and CD3+ T cells, with few B cells (CD20+) and few granulocytes. Follow-up was available in 5 cases; all 5 patients were alive and well 11 months to 10 years after diagnosis. In the rare instance in which a testicular specimen with orchitis is submitted for pathologic evaluation, diagnosis may be difficult. Familiarity with the pathologic changes characteristic of orchitis will help avoid misdiagnosis.

  18. Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir.

    Science.gov (United States)

    Koonsaeng, S; Verschraegen, C; Freedman, R; Bossens, M; Kudelka, A; Kavanagh, J; Sittisomwong, T; DeClercq, E; Snoeck, R

    2001-06-01

    Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia. Copyright 2001 Wiley-Liss, Inc.

  19. Laparoscopic wedge resection of synchronous gastric intraepithelial neoplasia and stromal tumor: a case report.

    Science.gov (United States)

    Mou, Yi-Ping; Xu, Xiao-Wu; Xie, Kun; Zhou, Wei; Zhou, Yu-Cheng; Chen, Ke

    2010-10-21

    Synchronous occurrence of epithelial neoplasia and gastrointestinal stromal tumor (GIST) in the stomach is uncommon. Only rare cases have been reported in the literature. We present here a 60-year-old female case of synchronous occurrence of gastric high-level intraepithelial neoplasia and GIST with the features of 22 similar cases and detailed information reported in the English-language literature summarized. In the present patient, epithelial neoplasia and GIST were removed en bloc by laparoscopic wedge resection. To the best of our knowledge, this is the first reported case treated by laparoscopic wedge resection.

  20. Las innombrables

    OpenAIRE

    Lagarde, Marcela

    1998-01-01

    Desde 1789 los Derechos del Hombre son signo de la democracia moderna y de la emergencia de la ciudadanía como cualidad potencialmente universal. Sin embargo, siglo y medio después ya habían mostrado su insuficiencia y fueron reformulados con el nombre de Derechos Humanos por Eleanor Roosevelt, quien los llamó humanos y no del hombre, para evidenciar que el concepto anterior sólo se refería a los hombres, a los varones, y para incorporar a las mujeres de una manera explícita: humanos, en plur...

  1. Las Farmacodependencias

    Directory of Open Access Journals (Sweden)

    José Francisco Socarrás

    1994-09-01

    Full Text Available

    Ahora, cuando la Corte Constitucional ha despenalizado al farmacodependiente por el consumo de drogas, conviene informar sobre las consecuencias perjudiciales de estas. A quienes deseen un conocimiento detallado al respecto, les recomiendo documentarse en “Enciclopedia de Psiquiatría”, publicada por “El Ateneo” en Buenos Aires.

    El Capítulo respectivo es del doctor Daniel L. Murguia. El denominador corriente de su abuso es sencillamente la dependencia, nombre propuesto por la Organización Mundial de la Salud, definido como el “estado psíquico y a veces físico causado por la interacción entre un organismo vivo y un fármaco”. Su carácter esencial es el impulso psicofísico a consumir el producto en forma continua o periódica, con el fin de experimentar los efectos que acarrea y evitar los malestares de su privación. Todas las drogas del respectivo género, consumidas a dosis altas, tienen efectos psicotóxicos que alteran la conducta y en algunos casos conducen a la muerte.

    Los expertos de la Organización Mundial califican las mencionadas sustancias en seis grupos, a saber:

    1. Morfina y opiáceas, los cuales crean dependencia física y psicológica, con tolerancia precoz, necesidad de aumentar las dosis y síndrome de abstinencia bastante peligroso. Entre los derivados se cuentan los siguientes: Hidromorfina (Dilaudid; oximorfina (Nurmophan; heroína,
    éter diacético de la morfina (Diacetilmorfina; codeína (Metilmorfina; hidrocodeína (Hicadan’ oxicodeína (Perdocan. Los efectos de los opiáceo~ son los siguientes: analgesia, depresión respiratoria y espasmo gastrointestinal. Las dosis tóxicas pueden provocar convulsiones.

    2. Barbitúricos, alcohol y sedantes como el fenobarbital, que provocan así mismo dependencia física.

    3. Anfetaminas, en particular la Bencedrina inhalante, que acarrea dependencia psicológica.

    4. Cocaína, cuya dependencia psíquica es tal que muchos

  2. Neoplasia hematodérmica CD4+ CD56+ en la infancia Hematodermic CD4+ CD56+ neoplasm in childhood

    Directory of Open Access Journals (Sweden)

    Erica A. Rojas Bilbao

    2008-04-01

    Full Text Available La neoplasia hematodérmica CD4+ CD56+ con fenotipo de célula dendrítica plasmocitoide es una rara y agresiva neoplasia recientemente reconocida por la WHO-EORTC classification. Afecta adultos de edad media y ancianos, siendo muy pocos los casos descriptos en niños. Presentamos el caso de una niña de 12 años con grave retraso mental, estigmas genéticos y múltiples lesiones cutáneas localizadas en miembros inferiores y superiores. Histológicamente se observó un infiltrado dérmico difuso de células pequeñas y medianas con expresión de CD4, CD56, CD43 y S100 así como de marcadores dendríticos plasmocitoides: CD 123 y BDCA-2 confirmados por citometría de flujo, sin compromiso de sangre periférica ni médula ósea. Cumpliendo dos semanas de tratamiento para leucemia linfoblástica aguda evolucionó con remisión clínica de las lesiones cutaneas.Hematodermic CD4+ CD56+ neoplasm with plasmacytoid dendritic cell phenotype is a rare and aggressive neoplasm recently recognized by the WHO-EORTC classification. It generally appears in elderly adults, exceptionally in childhood. We present a 12-year-old girl with severe mental retardation, genetic clinical features and multiple nodular cutaneous lesions on legs and arms. Histologically the nodules showed diffuse dermal infiltrate of medium and small cells and expression of CD4, CD56, CD43, S100 and plasmacytoid dendritic markers: CD123, BDCA-2 under flow cytometry study. Peripheral blood and bone marrow were not involved. Clinical remission of cutaneous lesions was observed after two weeks of acute lymphoblastic leukemia therapy.

  3. Genome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia

    NARCIS (Netherlands)

    Lendvai, Ágnes; Johannes, Frank; Grimm, Christina; Eijsink, Jasper J H; Wardenaar, René; Volders, Haukeline H; Klip, Harry G; Hollema, Harry; Jansen, Ritsert C; Schuuring, Ed; Wisman, G Bea A; van der Zee, Ate G J

    2012-01-01

    Epigenetic modifications, such as aberrant DNA promoter methylation, are frequently observed in cervical cancer. Identification of hypermethylated regions allowing discrimination between normal cervical epithelium and high-grade cervical intraepithelial neoplasia (CIN2/3), or worse, may improve curr

  4. The Relationship Between Distal and Proximal Colonic Neoplasia: A Meta-Analysis

    NARCIS (Netherlands)

    Dodou, D.; De Winter, J.C.F.

    2011-01-01

    To investigate the association between proximal colonic neoplasia and distal lesions as a function of the lesion type. The extent to which health, demographic, and study characteristics moderate this association was also examined.

  5. Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia:repor t of a case

    Institute of Scientific and Technical Information of China (English)

    Rajkumar Krishnasamy; Shaleen Agarwal; Shivendra Singh; Sunil Puri; Puja Sakhuja; Anil K Agarwal

    2007-01-01

    BACKGROUND:The presence of pancreatic ductal intraepithelial neoplasia in patients with chronic pancreatitis is a risk factor for development of pancreatic adenocarcinoma. METHOD: A case of pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia was diagnosed in the setting of chronic pancreatitis. RESULTS:Distal pancreatectomy combined with splenec-tomy was performed with a diagnosis of pancreatic body carcinoma. Histopathological examination suggested adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia. The tumor was detected in the remaining head of the pancreas, for which a total pancreatectomy was done. CONCLUSIONS: When a patient with pancreatic ductal intraepithelial neoplasia associated with adenocarcinoma of the pancreas in the setting of chronic pancreatitis is at an increased risk of recurrence in the remaining pancreatic parenchyma, total pancreatectomy may be feasible.

  6. Fatal cases of gestational trophoblastic neoplasia over four decades in the Netherlands: a retrospective cohort study

    NARCIS (Netherlands)

    Lybol, C.; Centen, D.W.; Thomas, C.M.G.; ten Kate-Booij, M.J.; Verheijen, R.H.; Sweep, F.C.; Ottevanger, P.B.; Massuger, L.F.A.G.

    2012-01-01

    OBJECTIVE: To describe fatal cases of gestational trophoblastic neoplasia (GTN) over four decades and evaluate whether treatment was given according to the protocol and reveal possible implications for future management. DESIGN: Retrospective cohort study. SETTING: The Netherlands. POPULATION: Women

  7. Genome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia

    NARCIS (Netherlands)

    Lendvai, Ágnes; Johannes, Frank; Grimm, Christina; Eijsink, Jasper J H; Wardenaar, René; Volders, Haukeline H; Klip, Harry G; Hollema, Harry; Jansen, Ritsert C; Schuuring, Ed; Wisman, G Bea A; van der Zee, Ate G J

    2012-01-01

    Epigenetic modifications, such as aberrant DNA promoter methylation, are frequently observed in cervical cancer. Identification of hypermethylated regions allowing discrimination between normal cervical epithelium and high-grade cervical intraepithelial neoplasia (CIN2/3), or worse, may improve curr

  8. Aportación al conocimiento clínico y prosnóstico de los Linfomas de Cabeza y Cuello

    OpenAIRE

    Gómez Gómez, Mª José

    2015-01-01

    Los linfomas son neoplasias del sistema linforreticular que asientan preferentemente en los ganglios linfáticos. Representan aproximadamente el 5% de todas las neoplasias malignas que se pueden desarrollar en la región anatómica de la cabeza y cuello. En general los Linfomas no Hodgkin son más frecuentes que los Hodgkin y suponen el 88% de todos los linfomas. En términos generales el modo de presentación más frecuente y común de estos tumores en esta región anatómica es la aparición de ad...

  9. Tabaco y lesiones premalignas. Prevención del cáncer oral

    OpenAIRE

    Costela Serrano, Carmen; Murcia Gallardo, Gloria Rosa; Perandrés Yuste, Sergio Antonio

    2015-01-01

    Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de Madrid Introducción: el cáncer de cabeza y cuello representa el 5% de todas las neoplasias del organismo. El carcinoma oral de células escamosas es la neoplasia maligna más frecuente en la cavidad oral. Su mortalidad a los cinco años es del 50%, de ahí la importancia del diagnóstico precoz y de su prevención. El precancer es una situación pr...

  10. ¿CÓMO PUEDO MODIFICAR MI RIESGO A DESARROLLAR CÁNCER, CUANDO SOY PORTADOR DE UNA MUTACIÓN?

    Directory of Open Access Journals (Sweden)

    Dra. Yenni Rodríguez, MD

    2017-07-01

    Las estrategias para modificar el riesgo variarán con el conocimiento de la epidemiología, la etiología y los mecanismos moleculares específicos para cada cáncer individual. Los síndromes hereditarios de cáncer facilitarán este estudio ya que a medida que se disponga de más información sobre la genómica humana, será posible una comprensión clara de los mecanismos moleculares subyacentes de estas enfermedades y posiblemente resulten en estrategias eficaces para su control. Desafortunadamente, a pesar del amplio conocimiento disponible sobre los factores de riesgo para muchas de estas neoplasias malignas, hemos sido incapaces de influir en cambios efectivos en el estilo de vida que podrían reducir sustancialmente el riesgo de estas neoplasias malignas en nuestra población.

  11. Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia.

    OpenAIRE

    Ismail, S. M.; Colclough, A. B.; Dinnen, J. S.; Eakins, D.; Evans, D M; Gradwell, E.; O'Sullivan, J. P.; Summerell, J M; Newcombe, R G

    1989-01-01

    To assess the variability among histopathologists in diagnosing and grading cervical intraepithelial neoplasia eight experienced histopathologists based at different hospitals examined the same set of 100 consecutive colposcopic cervical biopsy specimens and assigned them into one of six diagnostic categories. These were normal squamous epithelium, non-neoplastic squamous proliferations, cervical intraepithelial neoplasia grades I, II, and III, and other. The histopathologists were given curr...

  12. A new association – multiple endocrine neoplasia type 1 and malignant peripheral nerve sheath tumor

    OpenAIRE

    Preda, Veronica; Sywak, Mark; Learoyd, Diana

    2014-01-01

    Key Clinical Message We report a patient with multiple endocrine neoplasia type 1 (MEN-1) and an aggressive malignant peripheral nerve sheath tumor (MPNST) arising from a ganglioneuroma of the adrenal gland. Patients with MEN-1 require careful consideration of other tumor associations, including MPNST, as it can portend a poor prognosis. MEN-1 and MPNST have not been reported. We report a patient with multiple endocrine neoplasia type 1 (MEN-1) and an aggressive malignant peripheral nerve she...

  13. Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

    Science.gov (United States)

    Park, Youn Su; Kim, Ji Won; Kim, Byeong Gwan; Lee, Kook Lae; Lee, Jae Kyung; Kim, Joo Sung; Koh, Seong-Joon

    2017-04-01

    Although sarcopenia is associated with an increased risk for mortality after the curative resection of colorectal cancer, its influence on the development of advanced colonic neoplasia remains unclear. This study included 1270 subjects aged 40 years or older evaluated with first-time screening colonoscopy at Seoul National University Boramae Health Care Center from January 2010 to February 2015. Skeletal muscle mass was measured with a body composition analyzer (direct segmental multifrequency bioelectrical impedance analysis method). Multiple logistic regression analysis was performed to determine whether sarcopenia is associated with advanced colorectal neoplasia. Of 1270 subjects, 139 (10.9%) were categorized into the sarcopenia group and 1131 (89.1%) into the non-sarcopenia group. In the non-sarcopenia group, 55 subjects (4.9%) had advanced colorectal neoplasia. However, in the sarcopenia group, 19 subjects (13.7%) had advanced colorectal neoplasia, including 1 subject with invasive colorectal cancer (0.7%). In addition, subjects with sarcopenia had a higher prevalence of advanced adenoma (P sarcopenia. According to the multiple logistic regression analysis adjusted for variable confounders, age (odds ratio 1.062, 95% confidence interval 1.032-1.093; P sarcopenia (odds ratio 2.347, 95% confidence interval 1.311-4.202; P = 0.004) were associated with an advanced colorectal neoplasia. Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

  14. Genomas y cromosomas. Algunas certezas entre las tantas preguntas de los últimos 10 años.

    Directory of Open Access Journals (Sweden)

    Mudry Marta Dolores

    2011-12-01

    Full Text Available En el año 2000 se presentó lo que se dio en llamar nuestro libro de la vida, el primer borrador del Genoma Humano. Aquello generó grandes expectativas por sus potenciales aplicaciones en beneficio de las ciencias biológicas. ¿Qué ha sucedido 10 años después? Se conoce cuántos genes tenemos en nuestro genoma y se analizó la función de algunos de ellos. Se conocen las secuencias de los genomas de unos 14 mamíferos y borradores o genomas completos de otros numerosos vertebrados, invertebrados, hongos, plantas y diversos microorganismos. Sin embargo, el estudio del genoma no se limita a la mera descripción de las secuencias que lo componen. Las respuestas que demos abarcarán enfoques muy diversos desde evolución y conservación de la biodiversidad hasta terapia génica y transformación maligna, donde el estudio de las respuestas individuales y poblacionales utiliza fuentes de información tanto pasadas como actuales sobre estos genomas en estudio. Así, los avances en ciencia siempre son provisorios y por tanto, pasibles de continuarse, completarse e incluso reinterpretarse ya que van surgiendo nuevas preguntas a medida que avanzamos en el conocimiento.

  15. Importancia de la extracción de las piezas de extirpación cólica protegidas en bolsa durante el tratamiento de la patología colorrectal por vía mínimamente invasiva. Estudio prospectivo multicéntrico

    OpenAIRE

    Valdés Hernández, Javier

    2016-01-01

    Falta palabras clave Introducción: Desde la introducción del abordaje laparoscópico para el tratamiento de la patología quirúrgica colorrectal, éste se ha instaurado como seguro y eficaz para el tratamiento de la patología, tanto benigna, como maligna. Sin embargo, con la aparición de nuevas vías de abordaje mínimamente invasivas, con la introducción del abordaje por puerto único y con mini instrumentos, nuevas necesidades y dudas han ido apareciendo sobre las posibles repercusiones que e...

  16. Diagnosis of gastric epithelial neoplasia: Dilemma for Korean pathologists

    Institute of Scientific and Technical Information of China (English)

    Joon Mee Kim; Eunsil Yu; Eun Sun Jung; Mee Soo Chang; Jong Eun Joo; Mee Joo; Youn Wha Kim; Do Youn Park; Yun Kyung Kang; Sun Hoo Park; Hye Seung Han; Mee-Yon Cho; Young Bae Kim; Ho Sung Park; Yang Seok Chae; Kye Won Kwon; Hee Jin Chang; Jin Hee Sohn; Dae Young Kang; Cheol Keun Park; Woo Ho Kim; So-Young Jin; Kyoung Mee Kim; Hee Kyung Chang

    2011-01-01

    The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important, but the diagnostic criteria, terminology, and grading system are not the same in the East and West. A structurally invasive focus is necessary to diagnose carcinoma for most are active. Additionally, Korean doctors are familiar with Western style medical terminology. As a result, the terminology, definitions, and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea. To solve this problem, the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis: (1) a diagnosis of carcinoma is based on invasion; (2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching, budding, or marked glandular crowding; (3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts, the lesion is considered high grade dysplasia; (4) if severe cytologic atypia is present, careful inspection for invasive foci is necessary, because the risk for invasion is very high; and (5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern, papillae, ridges, vesicular nuclei, high nuclear/cytoplasmic ratio, loss of nuclear polarity, thick and irregular nuclear membrane, and nucleoli.

  17. [Cervical intraepithelial neoplasia: Chlamydia trachomatis and other co-factors].

    Science.gov (United States)

    Núñez-Troconis, J T

    1995-09-01

    The incidence of Chlamydia trachomatis (Ct) in patients with diagnosis of Cervical Intraepithelial Neoplasia (CIN) was studied in one hundred eighty patients. The Chlamydiazyme test was performed in all of them. Endocervical samples were taken from 103 patients with CIN and 77 women who sought medical attention for different gynecological reasons (CG). Twenty three tests (12.8%) were positive; 15 of them had CIN (14.6%) and 8 were from the control group (10.4%). It was found a statistical significant difference between NIC III and early intercourse, NIC III and age, NIC and vaginal douches and, among NIC and number of pregnancies and deliveries. There was not a significant difference among Ct and early intercourse, number of sexual partners, pregnancies, deliveries, vaginal douches, oral contraceptives (OC), and vaginal discharge. No statistically significant differences were found between NIC and number of sexual partners, and OC and vaginal discharge. The low incidence of Ct in patients with CIN does not mean that Ct does not play a role in the origin and development of the cervical pathology.

  18. Challenges in automated detection of cervical intraepithelial neoplasia

    Science.gov (United States)

    Srinivasan, Yeshwanth; Yang, Shuyu; Nutter, Brian; Mitra, Sunanda; Phillips, Benny; Long, Rodney

    2007-03-01

    Cervical Intraepithelial Neoplasia (CIN) is a precursor to invasive cervical cancer, which annually accounts for about 3700 deaths in the United States and about 274,000 worldwide. Early detection of CIN is important to reduce the fatalities due to cervical cancer. While the Pap smear is the most common screening procedure for CIN, it has been proven to have a low sensitivity, requiring multiple tests to confirm an abnormality and making its implementation impractical in resource-poor regions. Colposcopy and cervicography are two diagnostic procedures available to trained physicians for non-invasive detection of CIN. However, many regions suffer from lack of skilled personnel who can precisely diagnose the bio-markers due to CIN. Automatic detection of CIN deals with the precise, objective and non-invasive identification and isolation of these bio-markers, such as the Acetowhite (AW) region, mosaicism and punctations, due to CIN. In this paper, we study and compare three different approaches, based on Mathematical Morphology (MM), Deterministic Annealing (DA) and Gaussian Mixture Models (GMM), respectively, to segment the AW region of the cervix. The techniques are compared with respect to their complexity and execution times. The paper also presents an adaptive approach to detect and remove Specular Reflections (SR). Finally, algorithms based on MM and matched filtering are presented for the precise segmentation of mosaicism and punctations from AW regions containing the respective abnormalities.

  19. Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: a review.

    Science.gov (United States)

    de Witte, C J; van de Sande, A J M; van Beekhuizen, H J; Koeneman, M M; Kruse, A J; Gerestein, C G

    2015-11-01

    Human papillomavirus (HPV) infection is in the vast majority of patients accountable for the development of vulvar, cervical and vaginal intraepithelial neoplasia (VIN, CIN, VAIN); precursors of vulvar, cervical and vaginal cancers. The currently preferred treatment modality for high grade VIN, CIN and VAIN is surgical excision. Nevertheless surgical treatment is associated with adverse pregnancy outcomes and recurrence is not uncommon. The aim of this review is to present evidence on the efficacy, safety and tolerability of imiquimod (an immune response modifier) in HPV-related VIN, CIN and VAIN. A search for papers on the use of imiquimod in VIN, CIN and VAIN was performed in the MEDLINE, EMBASE and Cochrane library databases. Data was extracted and reviewed. Twenty-one articles met the inclusion criteria and were analyzed; 16 on VIN, 3 on CIN and 2 on VAIN. Complete response rates in VIN ranged from 5 to 88%. Although minor adverse effects were frequently reported, treatment with imiquimod was well tolerated in most patients. Studies on imiquimod treatment of CIN and VAIN are limited and lack uniformly defined endpoints. The available evidence however, shows encouraging effect. Complete response rates for CIN 2-3 and VAIN 1-3 ranged from 67 to 75% and 57 to 86% respectively. More randomized controlled trials on the use of imiquimod in CIN, VAIN and VIN with extended follow-up are necessary to determine the attributive therapeutic value in these patients.

  20. INFECTION WITH HUMAN PAPILLOMA VIRUS IN CERVICAL NEOPLASIA

    Directory of Open Access Journals (Sweden)

    Eduard Crauciuc

    2010-09-01

    Full Text Available The purpose of this study was to establish if the infection with human papilloma virus (HPV presents a potential irreversible evolution towards malignancy. Materials and methods. The study was made on a number of 1885 patients that were suspected to have cervical neoplasia, which were monitored between 2001-2010 in „Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology in Ia�i, the Military Hospital Gala�i, the County Hospital Gala�i and the Emergency Hospital Buzau. Results and discussions. The study proved that the risk of contacting a genital infection with HPV and cervical cancer is influenced by the sexual activity, the risk of getting infected with HPV during a person’ s lifetime is at least 50% for those sexually active. Conclusions. The patients benefited from colposcopy and biopsy only if the repeated cytology suggested more severe changes. The conservative conduct is represented by a repeated cytology when the patients are admitted into the lot (the initial cytology is performed before this moment

  1. Gestational trophoblastic neoplasia with retroperitoneal metastases: A fatal complication

    Directory of Open Access Journals (Sweden)

    Dimopoulos Athanassios-Meletios

    2010-12-01

    Full Text Available Abstract Background Gestational Trophoblastic Neoplasia (GTN is a pathologic entity that can affect any pregnancy and develop long after the termination of the pregnancy. Its course can be complicated by metastases to distant sites such as the lung, brain, liver, kidney and vagina. The therapeutic approach of this condition includes both surgical intervention and chemotherapy. The prognosis depends on many prognostic factors that determine the stage of the disease. Case Report We present a woman with GTN and retroperitoneal metastatic disease who came to our department and was diagnosed as having high risk metastatic GTN. Accordingly she received chemotherapy as primary treatment but unfortunately developed massive bleeding after the first course of chemotherapy, was operated in an attempt to control bleeding but finally succumbed. Conclusion This case demonstrates that GTN, while usually curable, can be a deadly disease requiring improved diagnostic, treatment modalities and chemotherapeutic agents. The gynaecologist should be aware of all possible metastatic sites of GTN and the patient immediately referred to a specialist center for further assessment and treatment.

  2. Brain metastases from gestational trophoblastic neoplasia: review of pertinent literature.

    Science.gov (United States)

    Piura, E; Piura, B

    2014-01-01

    Brain metastasis from gestational trophoblastic neoplasia (GTN) is rare with about 222 cases documented in the literature and an incidence of about 11% in living GTN patients. Brain metastasis from GTN was part of a disseminated disease in 90% of patients, single metastases in the brain - 80% and located in the cerebrum - 90%. Brain metastasis was the only manifestation of metastatic GTN in 11.3% of patients, appeared synchronously with metastatic GTN in other sites of the body - 30.6% and was diagnosed from 0.3 to 60 months after diagnosis of metastatic GTN in other sites (most often in the lung) - 58.1%. Overall, 83.9% of patients with brain metastases from GTN had also lung metastases from GTN. Brain metastases from GTN showed a greater tendency to be hemorrhagic compared to brain metastases from other primaries. In patients with brain metastases from GTN, the best outcome was achieved with multimodal therapy including craniotomy, whole brain radiotherapy, and EP-EMA or EMA-CO chemotherapy. Nonetheless, brain metastasis from GTN is a grave disease with a median survival time from diagnosis of brain metastasis of about 12 months.

  3. Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia

    Directory of Open Access Journals (Sweden)

    Gorka Larrinaga

    2013-01-01

    Full Text Available Background. Papillary thyroid carcinoma (PTC, follicular thyroid adenoma (FTA, and thyroid nodular hyperplasia (TNH are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26 in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis/prognosis of these diseases. However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland. Methods. The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues. Results. The activity of DPPIV/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues. Aspartyl aminopeptidase (AspAP, alanyl aminopeptidase (AlaAP, prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues. AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH. Conclusions. These data suggest the involvement of DPPIV/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA. Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis/prognosis of thyroid neoplasms.

  4. Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis

    Science.gov (United States)

    Shah, Ankit; Espana, Edgar M.; Singh, Arun D.

    2017-01-01

    Purpose To describe 2 cases of invasive squamous cell carcinoma that originated in the setting of severe atopic keratoconjunctivitis (AKC). Methods Case one involved a 73-year-old male with atopic eczema and severe AKC who developed a limbal lesion suspicious for ocular surface squamous neoplasia (OSSN). Slit-lamp examination was significant for a new sessile lesion in the temporal limbal region of the left eye. The lesion was treated with excisional biopsy and cryotherapy. Topical therapy with mitomycin C, topical interferon alpha 2b, and topical 5-fluorouracil provided only partial control. Exenteration was eventually needed. Case two involved a 53-year-old male with history of severe AKC and eczema. Computed tomography imaging showed an infiltrative mass of the right orbit. Incisional biopsies confirmed conjunctival squamous cell carcinoma of both sides (invasive in the right eye, in situ in the left eye). Exenteration was needed for control of invasive carcinoma in the right eye. Results Squamous cell carcinoma was treated without success in spite of surgical excision and aggressive treatment with multiple topical agents and multiple applications of cryotherapy. Orbital exenteration was needed in both cases. Conclusion Chronic inflammation associated with AKC may be a risk factor for the development of bilateral, diffuse, invasive, and recurrent OSSN that may require exenteration.

  5. Cervical Intraepithelial Neoplasia Is Associated With Genital Tract Mucosal Inflammation

    Science.gov (United States)

    Mhatre, Mohak; McAndrew, Thomas; Carpenter, Colleen; Burk, Robert D.; Einstein, Mark H.; Herold, Betsy C.

    2013-01-01

    Background Clinical studies demonstrate increased prevalence of human papillomavirus (HPV)-associated disease in HIV-infected individuals and an increased risk of HIV acquisition in HPV-infected individuals. The mechanisms underlying this synergy are not defined. We hypothesize that women with cervical intraepithelial neoplasia (CIN) will exhibit changes in soluble mucosal immunity that may promote HPV persistence and facilitate HIV infection. Methods The concentrations of immune mediators and endogenous anti-Escherichia coli activity in genital tract secretions collected by cervicovaginal lavage were compared in HIV-negative women with high-risk HPV-positive (HRHPV+) CIN-3 (n = 37), HRHPV+ CIN-1 (n = 12), or PAP-negative control subjects (n = 57). Results Compared with control subjects, women with CIN-3 or CIN-1 displayed significantly higher levels of proinflammatory cytokines including interleukin (IL)-1α, IL-1β, and IL-8 (P < 0.002) and significantly lower levels of anti-inflammatory mediators and antimicrobial peptides, including IL-1 receptor antagonist, secretory leukocyte protease inhibitor (P < 0.01), and human β defensins 2 and 3 (P < 0.02). There was no significant difference in endogenous anti-E. coli activity after controlling for age and sample storage time. Conclusion HRHPV+ CIN is characterized by changes in soluble mucosal immunity that could contribute to HPV persistence. The observed mucosal inflammation suggests a mechanism that may also contribute to the epidemiologic link between persistent HPV and HIV. PMID:22801340

  6. In vivo detection of cervical intraepithelial neoplasia by multimodal colposcopy

    Science.gov (United States)

    Ren, Wenqi; Qu, Yingjie; Pei, Jiaojiao; Xiao, Linlin; Zhang, Shiwu; Chang, Shufang; Smith, Zachary J.; Xu, Ronald X.

    2016-03-01

    Cervical cancer is the leading cause of cancer death for women in developing countries. Colposcopy plays an important role in early screening and detection of cervical intraepithelial neoplasia (CIN). In this paper, we developed a multimodal colposcopy system that combines multispectral reflectance, autofluorescence, and RGB imaging for in vivo detection of CIN, which is capable of dynamically recording multimodal data of the same region of interest (ROI). We studied the optical properties of cervical tissue to determine multi-wavelengths for different imaging modalities. Advanced algorithms based on the second derivative spectrum and the fluorescence intensity were developed to differentiate cervical tissue into two categories: squamous normal (SN) and high grade (HG) dysplasia. In the results, the kinetics of cervical reflectance and autofluorescence characteristics pre and post acetic acid application were observed and analyzed, and the image segmentation revealed good consistency with the gold standard of histopathology. Our pilot study demonstrated the clinical potential of this multimodal colposcopic system for in vivo detection of cervical cancer.

  7. Gestational trophoblastic neoplasia: efficacy of color doppler ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Song, Sun Wha; Jee, Won Hee; Choe, Bo Young; Byun, Jae Young; Choi, Byung Gil; Shinn, Kyung Sub [Catholic Univ. College of Medicine, Seoul (Korea, Republic of)

    1997-04-01

    To evaluate the efficacy of color Doppler ultrasound (US) in the diagnosis of gestational trophoblastic neoplasia (GTN). Intralesional color flows and resistive index (RI) on color Doppler US were prospectively analyzed in 21 consecutive suspected GTN cases. RI of the intralesional artery was investigated on the basis of the presence or absence of mass and metastasis. Correlation between RI of intralesional artery and urinary {beta}-hCG was also investigated. Intralesional color flows were identified in 15 patients with GTN. On operation, intralesional color flows were observed in one of two patients in whom the presence of completely necrotic tissue was confirmed. Intralesional color flows, however, were not detected in four patients who were proved not to be GTN sufferers. Sensitivity, specificity, accuracy, positive and negative predictive values, and accuracy were 100%, 83%, 95%, 94% and 100%, respectively. Significant correlation between RI of the intralesional artery and urinary {beta}-hCG was not established (p=0.49, r=0.19). RI of this artery was not substantially different between groups with and without mass, and between groups with and without metastasis (p=0.32, p=0.82). The current study demonstrates that color Doppler US is a sensitive and useful method for the diagnosis of GTN.

  8. Helicobacter pylori and colorectal neoplasia: Is there a causal link?

    Science.gov (United States)

    Papastergiou, Vasilios; Karatapanis, Stylianos; Georgopoulos, Sotirios D

    2016-01-14

    Ever since Helicobacter pylori (H. pylori) was recognized as an infectious cause of gastric cancer, there has been increasing interest in examining its potential role in colorectal carcinogenesis. Data from case-control and cross-sectional studies, mostly relying on hospital-based samples, and several meta-analyses have shown a positive statistical relationship between H. pylori infection and colorectal neoplasia. However, the possibility exists that the results have been influenced by bias, including the improper selection of patients and disparities with respect to potential confounders. While the evidence falls short of a definitive causal link, it appears that infection with H. pylori/H. pylori-related gastritis is associated with an increased, although modest, risk of colorectal adenoma and cancer. The pathogenic mechanisms responsible for this association remain uncertain. H. pylori has been detected in colorectal malignant tissues; however, the possibility that H. pylori is a direct activator of colonic carcinogenesis remains purely hypothetical. On the other hand, experimental data have indicated a series of potential oncogenic interactions between these bacteria and colorectal mucosa, including induction and perpetuation of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators, such as gastrin, which may contribute to tumor formation.

  9. Screening, Surveillance, and Treatment of Anal Intraepithelial Neoplasia

    Science.gov (United States)

    Long, Kevin C.; Menon, Raman; Bastawrous, Amir; Billingham, Richard

    2016-01-01

    The prevalence of anal intraepithelial neoplasia has been increasing, especially in high-risk patients, including men who have sex with men, human immunodeficiency virus positive patients, and those who are immunosuppressed. Several studies with long-term follow-up have suggested that rate of progression from high-grade squamous intraepithelial lesions to invasive anal cancer is ∼ 5%. This number is considerably higher for those at high risk. Anal cytology has been used to attempt to screen high-risk patients for disease; however, it has been shown to have very little correlation to actual histology. Patients with lesions should undergo history and physical exam including digital rectal exam and standard anoscopy. High-resolution anoscopy can be considered as well, although it is of questionable time and cost–effectiveness. Nonoperative treatments include expectant surveillance and topical imiquimod or 5-fluorouracil. Operative therapies include wide local excision and targeted ablation with electrocautery, infrared coagulation, or cryotherapy. Recurrence rates remain high regardless of treatment delivered and surveillance is paramount, although optimal surveillance regimens have yet to be established. PMID:26929753

  10. ESTUDIO RETROSPECTIVO DE LAS AFECCIONES OBSTRUCTIVAS DE LAS VÍAS AÉREAS SUPERIORES EN EQUINOS ADULTOS PRESENTADOS A LA CLÍNICA PARA GRANDES ANIMALES DE LA UNIVERSIDAD NACIONAL DE COLOMBIA ENTRE 1993 Y 2007

    OpenAIRE

    Martínez, D. A.; Oliver, O. J.

    2012-01-01

    Se analizaron 44 historias de equinos admitidos en la Clínica de Grandes Animales de la Universidad Nacional de Colombia entre I-1993 y II-2007, para determinar las entidades obstructivas más prevalentes en el tracto respiratorio superior (cavidad nasal, faringe y laringe). Se determinó que el desplazamiento dorsal del paladar blando, la hemiplejia laríngea, la hiperplasia linfoide faríngea y las neoplasias fueron las entidades más prevalentes con 38,64%, 34,09%, 18,18% y 9,09%, respectivamen...

  11. Estudio retrospectivo de las afecciones obstructivas de las vias aereas superiores en equinos adultos presentados a la clinica para grandes animales de la universidad nacional de colombia entre 1993 y 2007

    OpenAIRE

    Martínez, D. A.; Oliver, O. J.

    2012-01-01

    Un total de 44 historias de animales admitidos en la Clínica para Grandes Animales de la Universidad Nacional de Colombia fueron analizadas, para determinar cuales fueron las entidades más prevalentes en el tracto respiratorio superior (cavidad nasal, faringe y laringe) de estos equinos. Se determinó que el desplazamiento dorsal del paladar blando, la hemiplejia laríngea, la hiperplasia faríngea linfoide y las neoplasias fueron las mas prevalentes con 38.64%, 34.09%, 18.18% y 9.09% respectiva...

  12. Estudio retrospectivo de las afecciones obstructivas de las vias aereas superiores en equinos adultos presentados a la clinica para grandes animales de la universidad nacional de colombia entre 1993 y 2007

    OpenAIRE

    Martínez, D. A.; Oliver, O. J.

    2012-01-01

    Un total de 44 historias de animales admitidos en la Clínica para Grandes Animales de la Universidad Nacional de Colombia fueron analizadas, para determinar cuales fueron las entidades más prevalentes en el tracto respiratorio superior (cavidad nasal, faringe y laringe) de estos equinos. Se determinó que el desplazamiento dorsal del paladar blando, la hemiplejia laríngea, la hiperplasia faríngea linfoide y las neoplasias fueron las mas prevalentes con 38.64%, 34.09%, 18.18% y 9.09% respectiva...

  13. ESTUDIO RETROSPECTIVO DE LAS AFECCIONES OBSTRUCTIVAS DE LAS VÍAS AÉREAS SUPERIORES EN EQUINOS ADULTOS PRESENTADOS A LA CLÍNICA PARA GRANDES ANIMALES DE LA UNIVERSIDAD NACIONAL DE COLOMBIA ENTRE 1993 Y 2007

    OpenAIRE

    Martínez, D. A.; Oliver, O. J.

    2012-01-01

    Se analizaron 44 historias de equinos admitidos en la Clínica de Grandes Animales de la Universidad Nacional de Colombia entre I-1993 y II-2007, para determinar las entidades obstructivas más prevalentes en el tracto respiratorio superior (cavidad nasal, faringe y laringe). Se determinó que el desplazamiento dorsal del paladar blando, la hemiplejia laríngea, la hiperplasia linfoide faríngea y las neoplasias fueron las entidades más prevalentes con 38,64%, 34,09%, 18,18% y 9,09%, respectivamen...

  14. Panorama epidemiológico de la mortalidad por cáncer en el Instituto Mexicano del Seguro Social: 1991-1995

    Directory of Open Access Journals (Sweden)

    SALMERÓN-CASTRO JORGE

    1997-01-01

    Full Text Available Objetivo. Describir el comportamiento de la mortalidad global por cáncer, así como la mortalidad específica para las principales neoplasias malignas en población adulta derechohabiente (DH del Instituto Mexicano del Seguro Social (IMSS. Material y métodos. A partir de los registros oficiales de defunción y de la información sobre la población para los años 1991-1995, se estimaron las tasas anuales de mortalidad global y específica para las 10 principales neoplasias malignas por sexo, en mayores de 20 años. Asimismo, se estimaron las tendencias nacionales y estatales para las principales neoplasias malignas para cada sexo por medio de regresión de Poisson. Se calcularon las diferencias de tasas de mortalidad específica para las dos principales neoplasias por sexo restando las tasas estatales a su respectiva tasa nacional en 1995. Resultados. La mortalidad global por cáncer en los hombres se incrementó de 76.2 en 1991, a 94.8 por 100 000 DH en 1995; entre las mujeres, ésta se incrementó de 85.6 a 105.8 por 100 000 DH, representando un incremento de 24.4 y de 24% en hombres y mujeres, respectivamente, durante el periodo de estudio. Entre los hombres las neoplasias de riñón, leucemia, páncreas, próstata y pulmón; y entre mujeres las de colon, mama, páncreas, leucemias e hígado, mostraron los incrementos más significativos. Conclusiones. En el IMSS es impostergable la conformación de un registro poblacional de cáncer que permita una mejor vigilancia epidemiológica de las neoplasias y una evaluación permanente del impacto de programas específicos para la prevención y control de este padecimiento en las instituciones.

  15. Las redes sociales presentes en las bibliotecas

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    Magda Cecilia Sandí Sandí

    2012-07-01

    Full Text Available El presente artículo pretende evidenciar la importancia del uso de las redes sociales en las bibliotecas como una herramienta y un canal de comunicación entre el bibliotecólogo y la comunidad de usuarios. Las redes sociales son una nueva forma de comunicarnos entre las y los usuarios del Internet, su uso es irrestricto y cada vez aumenta la comunidad de usuarios de estas herramientas en la red.

  16. Las redes sociales presentes en las bibliotecas

    Directory of Open Access Journals (Sweden)

    Magda Cecilia Sandí S.

    2012-01-01

    Full Text Available El presente artículo pretende evidenciar la importancia del uso de las redes sociales en las bibliotecas como una herramienta y un canal de comunicación entre el bibliotecólogo y la comunidad de usuarios. Las redes sociales son una nueva forma de comunicarnos entre las y los usuarios del Internet, su uso es irrestricto y cada vez aumenta la comunidad de usuarios de estas herramientas en la red.

  17. Genotipado del VPH como herramienta pronóstica en las lesiones CIN I

    OpenAIRE

    Cortés Alaguero, Caterina

    2014-01-01

    La neoplasia intraepitelial cervical (CIN) y el cáncer cervicouterino constituyen un importante problema de salud para las mujeres en todo el mundo. Los datos obtenidos en las numerosas investigaciones realizadas hasta ahora, ponen de manifiesto la existencia de una estrecha relación entre la aparición de alteraciones de diverso grado de malignidad en el tracto genital femenino y la presencia y persistencia del virus del papiloma humano (VPH) de alto riesgo oncogénico. En los últimos 40...

  18. Microscopía confocal en las enfermedades ampollosas subepidérmicas autoinmunes

    OpenAIRE

    Campos Domínguez, Minia

    2016-01-01

    Las enfermedades ampollosas subepidérmicas autoinmunes constituyen un complejo grupo de trastornos cutáneos en cuya patogenia se rompe la unión dermoepidérmica. Su alta morbilidad se debe a la afectación de grandes áreas cutáneas por ampollas, erosiones o cicatrices y a la posible afectación de las mucosas oral, conjuntival, laríngea, esofágica y genitourinaria. Además, se ha demostrado su asociación con enfermedades neurológicas degenerativas y neoplasias. Existe un gran solapamiento clínico...

  19. Postmolar gestational trophoblastic neoplasia: beyond the traditional risk factors.

    Science.gov (United States)

    Bakhtiyari, Mahmood; Mirzamoradi, Masoumeh; Kimyaiee, Parichehr; Aghaie, Abbas; Mansournia, Mohammd Ali; Ashrafi-Vand, Sepideh; Sarfjoo, Fatemeh Sadat

    2015-09-01

    To investigate the slope of linear regression of postevacuation serum hCG as an independent risk factor for postmolar gestational trophoblastic neoplasia (GTN). Multicenter retrospective cohort study. Academic referral health care centers. All subjects with confirmed hydatidiform mole and at least four measurements of β-hCG titer. None. Type and magnitude of the relationship between the slope of linear regression of β-hCG as a new risk factor and GTN using Bayesian logistic regression with penalized log-likelihood estimation. Among the high-risk and low-risk molar pregnancy cases, 11 (18.6%) and 19 cases (13.3%) had GTN, respectively. No significant relationship was found between the components of a high-risk pregnancy and GTN. The β-hCG return slope was higher in the spontaneous cure group. However, the initial level of this hormone in the first measurement was higher in the GTN group compared with in the spontaneous recovery group. The average time for diagnosing GTN in the high-risk molar pregnancy group was 2 weeks less than that of the low-risk molar pregnancy group. In addition to slope of linear regression of β-hCG (odds ratio [OR], 12.74, confidence interval [CI], 5.42-29.2), abortion history (OR, 2.53; 95% CI, 1.27-5.04) and large uterine height for gestational age (OR, 1.26; CI, 1.04-1.54) had the maximum effects on GTN outcome, respectively. The slope of linear regression of β-hCG was introduced as an independent risk factor, which could be used for clinical decision making based on records of β-hCG titer and subsequent prevention program. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  20. Atrial Fibrillation and Colonic Neoplasia in African Americans.

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    Mehdi Nouraie

    Full Text Available Colorectal cancer (CRC and atrial fibrillation/flutter (AF share several risk factors including increasing age and obesity. However, the association between CRC and AF has not been thoroughly examined, especially in African Americans. In this study we aimed to assess the prevalence of AF and its risk factors in colorectal neoplasia in an African American.We reviewed records of 527 African American patients diagnosed with CRC and 1008 patients diagnosed with benign colonic lesions at Howard University Hospital from January 2000 to December 2012. A control group of 731 hospitalized patients without any cancer or colonic lesion were randomly selected from the same time and age range, excluding patients who had diagnosis of both CRC and/or adenoma. The presence or absence of AF was based upon ICD-9 code documentation. The prevalence of AF in these three groups was compared by multivariate logistic regression.The prevalence of AF was highest among CRC patients (10% followed by adenoma patients (7.2% then the control group (5.4%, P for trend = 0.002. In the three groups of participants, older age (P<0.008 and heart failure (P<0.001 were significantly associated with higher risk of AF. After adjusting for these risk factors, CRC (OR: 1.4(95%CI:0.9-2.2, P = 0.2 and adenoma (OR: 1.1(95%CI:0.7-1.6, P = 0.7 were not significantly associated AF compared to control group.AF is highly prevalent among CRC patients; 1 in 10 patients had AF in our study. The predictors of AF in CRC was similar to that in adenoma and other patients after adjustment for potential confounders suggesting that the increased AF risk in CRC is explained by higher prevalence of AF risk factors.

  1. [Pleuropulmonary metastases originating from extra-thoracic neoplasia].

    Science.gov (United States)

    Badri, Farid; Batahar, Salma Ait; Idrissi, Safae El; Sajiai, Hafsa; Serhane, Hind; Amro, Lamyae

    2017-01-01

    The lungs receive the entire venous drainage of the body. This explains the high incidence of pleuropulmonary metastases originating from several cancers. The goal of this is to study the clinical manifestations of pleuro-pulmonary metastases originating from extra-thoracic cancers. We conducted a retrospective study of patients with pleuro-pulmonary metastasis whose data were collected in our department between January 2006 and december 2014. 76 patient medical records were studied. The average age was 50 years (aged 21-89 years) with a male predominance in 57.8% of cases. Clinical symptoms were mainly cough (32.8% of cases), dyspnea (23.7% of cases) and hemoptysis (11.2%). Primary cancers responsible for various pleuro-pulmonary metastases found in our case series were dominated by breast cancers in 27.6% of cases, gastro-intestinal cancers in 15.8% of cases, genital cancers in 9, 2% of cases, sarcomas in 7.8% of cases, renal cancers in 5.2% of cases, bladder cancers in 5.2% of cases, prostate cancers in 3.9% cases, ENT cancers in 3.9% of cases, thyroid cancers in 3.9% of cases, skin cancers in 2.6% of cases and cancers of unknown primary origin in 14.4% of cases respectively. Several radiologic features of pleuro-pulmonary metastases have been found in our case series; they can be isolated or combined. The most common radiologic aspect was multiple pulmonary nodules in 52.6% of cases, followed by pleurisies in 34.2% of cases, diffuse micronodules in 23.6% of cases and a solitary nodule in 3.94% of cases. Secondary pleuropulmonary cancers are frequent. They come in 3rd place after lymph nodes and liver metastases and are found in 30% of autopsies of patients with neoplasia.

  2. The clinical significance of lobular neoplasia on breast core biopsy.

    Science.gov (United States)

    Karabakhtsian, Rouzan G; Johnson, Ronald; Sumkin, Jules; Dabbs, David J

    2007-05-01

    A core biopsy diagnosis of atypical ductal epithelial hyperplasia is upstaged on follow-up excisional biopsy (FUEB) to in situ or invasive carcinoma in about 20% of cases, thus prompting a FUEB. In contrast, upstaging information for a core biopsy diagnosis of pure lobular neoplasia (LN), without mass lesions or other risk-associated lesions is less clear. In this retrospective study, we report the largest consecutive series of patients who had a breast core biopsy diagnosis of LN and a FUEB. Core needle breast biopsies with a diagnosis of LN were retrieved from our files for the period 1999 to 2005, yielding 110 patients. One hundred and one patients had a follow-up surgical excision. Cases of LN with coexisting high-risk lesions (n=9, 10%) were excluded from the study. Patients with associated mass lesions all had benign findings (n=15, 16%) and had no impact on the study results. The remaining 77 core biopsies had no masses or risk lesions and were mammographically Breast Imaging Reporting and Data System 4 (BIRADS) for microcalcifications. Overall, 8/77 (10%) of patients with a radiographic BIRADS 4 image with calcifications and a core biopsy diagnosis of LN on core biopsy were upstaged on FUEB to ductal carcinoma in situ or invasive carcinoma. The numbers upstaged from core biopsies were as follows: atypical lobular hyperplasia (ALH) 4/52 (8%), mixed ALH/lobular carcinoma in situ (LCIS) 1/9 (10%), and pure LCIS 3/16 (19%). A core biopsy of LCIS with neoplastic epithelial calcifications was nearly 3 times more likely to be upstaged on FUEB compared with ALH. We conclude that a finding of LN on breast core biopsy in a patient with a BIRADS 4 image and calcifications is associated with a risk of 8% to 19% of upstaging to a treatable disease on FUEB.

  3. RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.

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    Marcelo Antonio Pascoal-Xavier

    Full Text Available RAP1 (RAS proximate 1, a small GTP-binding protein of the RAS superfamily, is a putative oncogene that is highly expressed in several malignant cell lines and types of cancers, including some types of squamous cell carcinoma. However, the participation of RAP1 in cervical carcinogenesis is unknown. We conducted a cross-sectional study of paraffin-embedded cervical biopsies to determine the association of RAP1 with cervical intraepithelial neoplasia (CIN. Standard and quantitative immunohistochemistry assessment of RAP1 expression in fixed tissue was performed on 183 paraffin-embedded cervical biopsies that were classified as normal or non-dysplastic mucosa (NDM (n = 33; CIN grade 1 (n = 84 and CIN grade 2/3 (n = 66. A gradual increase in RAP1 expression in NDM < CIN 1 < CIN 2/3 (p<0.001 specimens was observed and was in agreement with the histopathologic diagnosis. A progressive increase in the RAP1 expression levels increased the risk of CIN 1 [odds ratio (OR = 3.50; 95% confidence interval (CI 1.30-10.64] 3.5 fold and the risk of CIN 2/3 (OR = 19.86, 95% CI 6.40-70.79 nearly 20 fold when compared to NDM. In addition, stereotype ordinal regression analysis showed that this progressive increase in RAP1 expression more strongly impacted CIN 2/3 than CIN 1. Our findings suggest that RAP1 may be a useful biomarker for the diagnosis of CIN.

  4. Gigantism in sibling unrelated to multiple endocrine neoplasia: case report.

    Science.gov (United States)

    Matsuno, A; Teramoto, A; Yamada, S; Kitanaka, S; Tanaka, T; Sanno, N; Osamura, R Y; Kirino, T

    1994-11-01

    The cases of gigantism sisters with somatotroph adenomas unrelated to multiple endocrine neoplasia (MEN) Type 1 are reported. The sisters grew rapidly since they were 5 or 6 years old and were diagnosed to have gigantism with pituitary adenoma by computed tomographic scan and magnetic resonance imaging. A serum endocrinological examination showed the elevated growth hormone values. After thyroxine-releasing hormone stimulation, growth hormone values exhibited a paradoxical rise. They were supposed to be unrelated to MEN Type 1, because analysis of the 11th chromosomes and the other endocrine functions were normal. They were operated on by the transphenoidal method. Immunohistochemical staining of both tumor specimens confirmed somatotroph adenomas. Pituitary adenoma associated with MEN Type 1 is a well-recognized entity. However, the sporadic occurrence of pituitary adenoma unrelated to MEN Type 1, especially in siblings, is extremely rare. Fifteen cases of pituitary adenomas in siblings were described in the literature. As for gigantism, only two brothers were reported. Our case of gigantism sisters is the second sporadic case. In our review of the isolated cases of pituitary adenoma in siblings described in the literature, 12 (70%) of 17 cases including ours are acromegaly or gigantism. This incidence is much higher than that of MEN Type 1 patients with pituitary adenomas. The cause of the familial occurrence of pituitary adenomas is still unclear, although autosomal recessive inheritance has been suggested. It has been stated that point mutations in codon 201 or 227 of the Gs alpha gene located in chromosome 20 were found in about 35 to 40% of somatotroph adenomas.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Multiple endocrine neoplasias: advances and challenges for the future.

    Science.gov (United States)

    Alevizaki, M; Stratakis, C A

    2009-07-01

    Several important advances have been made over the last 2 years, since the last international workshop on multiple endocrine neoplasias (MENs) that was held in Marseilles, France (MEN2006). The series of articles that are included in this issue summarize the most important of these advances as they were presented in Delphi, Greece, during the 11th International Workshop on MENs, September 25-27, 2008 (MEN2008). This editorial summarizes some of these advances: the identification of the AIP, and the PDE11A and PDE8B genes by genome-wide association (GWA) studies as predisposing genes for pituitary and adrenal tumours, respectively, the discovery of p27 mutations in a new form of MEN similar to MEN type 1 (MEN 1) that is now known as MEN 4, the molecular investigations of Carney triad (CT), a disorder that associates paragangliomas (PGLs), gastrointestinal stromal tumour (GISTs), and pulmonary chondromas (PCH) with pheochromocytomas and adrenocortical adenomas and other lesions, and the molecular elucidation of the association of GISTs with paragangliomas (Carney-Stratakis syndrome) that is now known to be because of SDHB, SDHC, and SDHD mutations. Molecular investigations in Carney complex (another MEN also described by Dr. Carney, who during the meeting, along with Dr. Charles E. ('Gene') Jackson was honoured for his life-long and many contributions to the field) have also revealed the role of cyclic AMP signalling in tumorigenesis. As our knowledge of the molecular causes of MENs increases, the challenge is to translate these discoveries in better treatments for our patients. Indeed, new advances in the preventive diagnosis and molecular treatment of MEN 1 and MEN 2, respectively, continued unabated, and an update on this front was also presented at MEN2008 and is included in this issue.

  6. Risk factors for the development of vaginal intraepithelial neoplasia

    Institute of Scientific and Technical Information of China (English)

    LI Hua; GUO Yan-li; ZHANG Jing-xu; QIAO Jie; GENG Li

    2012-01-01

    Background Vaginal intraepithelial neoplasia (VAIN),as aprecursor of vaginal cancer,is a rare disease.Its prevalence has not been well analyzed.This research is to ascertain the risk factors for VAIN in a Chinese population.@@Methods A case-control study was conducted,including 63 VAIN cases and 64healthy controls.In all subjects Pap smear and HPV tests were performed.A questionnaire survey was distributed,covering information on socio-demographic characteristics,smoking,past history,reproductive and sexual histories.The clinical pathological data were collected from medical records including symptoms,Pap smear results,grade of lesions,and human papillomavirus (HPV) status.@@Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women (95% C/:1.10-3.85; P=0.024).The patients with previous hysterectomy had an increased risk of VAIN (OR=4.69; P=0.003).Patients with a history of cervical cancer or CIN were predisposed to VAIN (OR=78.75; P <0.0001).The rate of HPV infection in VAIN was significantly higher than in controls,and an increased risk of VAIN was observed in patients with higher viral load (OR=126.00; P=0.000).Multivariate analysis showed that HPV infection and a history of CIN or cervical cancer were still found to be significant in patients.@@Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN.

  7. Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia

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    Nagayasu Egawa

    2015-07-01

    Full Text Available Papillomaviruses have evolved over many millions of years to propagate themselves at specific epithelial niches in a range of different host species. This has led to the great diversity of papillomaviruses that now exist, and to the appearance of distinct strategies for epithelial persistence. Many papillomaviruses minimise the risk of immune clearance by causing chronic asymptomatic infections, accompanied by long-term virion-production with only limited viral gene expression. Such lesions are typical of those caused by Beta HPV types in the general population, with viral activity being suppressed by host immunity. A second strategy requires the evolution of sophisticated immune evasion mechanisms, and allows some HPV types to cause prominent and persistent papillomas, even in immune competent individuals. Some Alphapapillomavirus types have evolved this strategy, including those that cause genital warts in young adults or common warts in children. These strategies reflect broad differences in virus protein function as well as differences in patterns of viral gene expression, with genotype-specific associations underlying the recent introduction of DNA testing, and also the introduction of vaccines to protect against cervical cancer. Interestingly, it appears that cellular environment and the site of infection affect viral pathogenicity by modulating viral gene expression. With the high-risk HPV gene products, changes in E6 and E7 expression are thought to account for the development of neoplasias at the endocervix, the anal and cervical transformation zones, and the tonsilar crypts and other oropharyngeal sites. A detailed analysis of site-specific patterns of gene expression and gene function is now prompted.

  8. Cushing’s Syndrome in Multiple Endocrine Neoplasia Type 1

    Science.gov (United States)

    Simonds, William F.; Varghese, Sarah; Marx, Stephen J.; Nieman, Lynnette K.

    2011-01-01

    Summary Objective In patients with multiple endocrine neoplasia type 1 (MEN1), Cushing’s syndrome (CS) from endogenous hypercortisolism can result from pituitary, adrenal, or other endocrine tumors. The purpose of this study was to characterize the range of presentations of CS in a large series of MEN1 patients. Design Retrospective review of NIH Clinical Center inpatient records over an approximately 40 year period. Patients 19 patients (8 males, 11 females) with CS and MEN1. Measurements Biochemical, imaging, surgical, and pathological findings. Results An etiology was determined for 14 of the 19 patients with CS and MEN1: 11 (79%) had Cushing’s disease (CD) and three (21%) had ACTH-independent CS due to adrenal tumors, frequencies indistinguishable from sporadic CS. Three of 11 MEN1 patients with CD (27%) had additional non-ACTH secreting pituitary microadenomas identified at surgery, an incidence 10-fold higher than in sporadic CD. Ninety-one percent of MEN1 patients with CD were cured after surgery. Two of three MEN1 patients with ACTH-independent CS (67%) had adrenocortical carcinoma. One patient with adrenal cancer and another with adrenal adenoma were cured by unilateral adrenalectomy. No case of ectopic ACTH secretion was identified in our patient cohort. The etiology of CS could not be defined in five patients; in three of these, hypercortisolism appeared to resolve spontaneously. Conclusions The tumor multiplicity of MEN1 can be reflected in the anterior pituitary, MEN1-associated ACTH-independent CS may be associated with aggressive adrenocortical disease, and an etiology for CS in MEN1 may be elusive in a substantial minority of patients. PMID:21916912

  9. Lifetime prevalence of cervical neoplasia in addicted and medical patients.

    Science.gov (United States)

    Reece, Albert

    2007-10-01

    The prevalence and timing of cervical dysplasia among substance use disorder (SUD) patients is not well studied. A cross-sectional pilot survey was undertaken among our primary practice female medical and SUD patients by patient recall of cervical screening history. One hundred and fifty-three SUD patients were compared with 77 general medical patients younger than 45 years old. The substances abused in this population have previously been described. There was no difference in the mean number of Pap smears (mean +/- SEM 6.30 +/- 0.55 vs 5.68 +/- 0.70, respectively) or the time since last screening (2.93 +/- 0.29 vs 1.60 +/- 0.26 years). Limiting the analysis to patients younger than 45 years effectively controlled for the difference in ages between SUD and medical patients (29.94 +/- 0.52 and 30.21 +/- 1.04 years). Significant differences in cytological abnormalities (OR = 5.88, CI 1.92-23.92; P = 0.0005), cervical intraepithelial neoplasia (CIN) (OR = 14.4, CI 2.20-602.92, P = 0.001) and high-grade CIN-cancer (P = 0.002) were noted. When diagnoses were scored and charted, the trend of the lines of best fit in the two groups was significantly different (P < 0.00001). There were five and two cancers noted in the two groups. There were two and ten hysterectomies performed in the two groups which were for two and one indications of cancer, respectively. In the addicted group invasive cancer was diagnosed at 23-, 23-, 34- and 37-years olds. SUD patients have a very high rate of abnormalities on cervical screening including precancerous lesions and these changes occurred at significantly younger ages. The possibility of some form of cancer promotion merits further investigation.

  10. Anal intraepithelial neoplasia: A review of diagnosis and management.

    Science.gov (United States)

    Roberts, Joseph R; Siekas, Lacey L; Kaz, Andrew M

    2017-02-15

    Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus (HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior. A history of HPV-mediated genital cancer, which suggests infection with an oncogenic HPV strain, is another risk factor for AIN/anal cancer. Because progression of AIN to anal cancer is known to occur in some individuals over several years, screening for AIN and early anal cancer, as well as treatment of advanced AIN lesions, is reasonable in certain high-risk populations. Although randomized controlled trials evaluating screening and treatment outcomes are lacking, experts support routine screening for AIN in high risk populations. Screening is performed using anal cytological exams, similar to those performed in cervical cancer screening programs, along with direct tissue evaluation and biopsy via high resolution anoscopy. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. Reductions in AIN and anal cancer rates have been shown in studies where high-risk populations were vaccinated against the oncogenic strains of HPV. Currently, the CDC recommends both high-risk and average-risk populations be vaccinated against HPV infection using the quadrivalent or nonavalent vaccines. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations.

  11. Anal intraepithelial neoplasia: A review of diagnosis and management

    Science.gov (United States)

    Roberts, Joseph R; Siekas, Lacey L; Kaz, Andrew M

    2017-01-01

    Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus (HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior. A history of HPV-mediated genital cancer, which suggests infection with an oncogenic HPV strain, is another risk factor for AIN/anal cancer. Because progression of AIN to anal cancer is known to occur in some individuals over several years, screening for AIN and early anal cancer, as well as treatment of advanced AIN lesions, is reasonable in certain high-risk populations. Although randomized controlled trials evaluating screening and treatment outcomes are lacking, experts support routine screening for AIN in high risk populations. Screening is performed using anal cytological exams, similar to those performed in cervical cancer screening programs, along with direct tissue evaluation and biopsy via high resolution anoscopy. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. Reductions in AIN and anal cancer rates have been shown in studies where high-risk populations were vaccinated against the oncogenic strains of HPV. Currently, the CDC recommends both high-risk and average-risk populations be vaccinated against HPV infection using the quadrivalent or nonavalent vaccines. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations. PMID:28255426

  12. Current treatment options for management of anal intraepithelial neoplasia

    Science.gov (United States)

    Weis, Stephen E

    2013-01-01

    Anal squamous cell cancer is an uncommon malignancy caused by infection with oncogenic strains of Human papilloma virus. Anal cancer is much more common in immunocompromised persons, including those infected with Human immunodeficiency virus. High-grade anal intraepithelial neoplasia (HGAIN), the precursor of anal cancer, is identified by clinicians providing care for patients with anorectal disease, and is increasingly being identified during screening of immunosuppressed patients for anal dysplasia. The traditional treatment for HGAIN has been excision of macroscopic disease with margins. This approach is effective for patients with small unifocal HGAIN lesions. Patients with extensive multifocal HGAIN frequently have recurrence of HGAIN after excision, and may have postoperative complications of anal stenosis or fecal incontinence. This led to the suggestion by some that treatment for HGAIN should be delayed until patients developed anal cancer. Alternative approaches in identification and treatment have been developed to treat patients with multifocal or extensive HGAIN lesions. High-resolution anoscopy combines magnification with anoscopy and is being used to identify HGAIN and determine treatment margins. HGAIN can then be ablated with a number of modalities, including infrared coagulation, CO2 laser, and electrocautery. These methods for HGAIN ablation can be performed with local anesthesia on outpatients and are relatively well tolerated. High-resolution anoscopy-directed HGAIN ablation is evolving into a standard approach for initial treatment and then subsequent monitoring of a disease which should be expected to be recurrent. Another treatment approach for HGAIN is topical treatment, principally with 5-fluorouracil or imiquimod. Topical therapies have the advantage of being nonsurgical and are well suited for treating widespread multifocal disease. Topical treatments have the disadvantage of requiring extended treatment courses and causing a symptomatic

  13. Metastatic multiple endocrine neoplasia type 1: report of one case

    Science.gov (United States)

    Huang, Cheng; Zhu, Xiaodong; Han, Xu

    2016-01-01

    A 46-year-old Chinese woman was admitted to our hospital because of presence of space-occupying lesions in the liver for 2 months in April, 2015. She had a family history of multiple endocrine neoplasia type 1 (MEN1) and physical examination is unremarkable. Previously, she has performed surgery for primary pituitary tumor in 2002 and radiosurgery for its recurrence. Around December 2014, she suffered from abdominal discomfort associated with regurgitation and gastroscopy revealed “gastroduodenal ulcers”, along with elevated gastrin. Next, both magnetic resonance and computed tomography imaging showed multiple intrahepatic lesions, the PET-CT unveiled uptake pattern of 18F-FDG in duodenum and multiple intrahepatic lesions, resembling the appearance of metastatic gastrinoma. The octreotide scan gave identical results. The parathyroid SPECT scans showed abnormal concentrations of radioactivity in right parathyroid. She also had an elevated serum chromogranin A (CgA) level. There was medical evidence to show that she is metastatic MEN1. Although multiple liver metastases, they were considered to be resectable after MDT consultation. The intraoperative exploration found a 1.5 cm tumor on the surface of the tail of the pancreas, a 12 cm retroperitoneal lipoma and two liver metastases, sized 3.5 cm and 1.5 cm, respectively. All these tumors were completely removed. For pancreatic tumor, pathological findings met the diagnostic criteria of neuroendocrine tumor (NET) (G2). Immunohistochemistry revealed neuroendocrine areas were diffusely positive for ATRX, DAXX, SSR2, SSR5 and CgA. For lipoma, the FISH results were negative for CDK4 and MDM2 genes. Postoperatively, adjuvant therapy with octreotide was applied. This case suggested that, as for metastatic gastrinoma, a potentially curative surgical debulking should be considered when a resection of complete or more than 90% of metastatic lesions along with the primary site could be achieved, which is helpful to control

  14. MASAS ADRENALES: PAPEL ACTUAL DE LAS IMÁGENES DIAGNÓSTICAS Masses adrenales: the current role of diagnostic images

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    César Augusto Poveda

    2012-03-01

    Full Text Available En este artículo se describe el rol que desempeñan en la actualidad las imágenes diagnósticas, en especial la tomografía computarizada y la resonancia magnética, para el diagnóstico d e masas adrenales. Se exponen los conceptos de lavado en tomografía y desplazamiento químico en resonancia magnética en la caracterización morfológica y dinámica con el medio de contraste de las misma y se revisan las patologías más frecuentes con énfasis en la diferenciación entre patología benigna y maligna. Se sugiere un diagrama de flujo del diagnóstico de las masas adrenales.This article describes the role currently being played by diagnostic images (especially computerised tomography and magnetic resonance for diagnosing adrenal masses. It deals with the concepts of washing in tomography and chemical displacement in magnetic resonance in morphological and dynamic characterisation with pertinent contrast medium and reviews the most frequent pathologies, emphasising differentiation between benign and malign pathologies. A flow diagram for adrenal mass diagnosis is suggested.

  15. Papel da criocirurgia no tratamento das neoplasias cutâneas do segmento cabeça e pescoço: análise de 1900 casos Role of cryosurgery treatment on cutaneous neoplasms of the head and neck: analysis of 1900 cases

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    Antonio Azoubel Antunes

    2006-04-01

    Full Text Available OBJETIVO: Demonstrar a experiência dos autores na utilização da criocirurgia como tratamento de lesões benignas e malignas da pele e mucosa no segmento cabeça e pescoço. MÉTODO: Os autores realizam um estudo retrospectivo multicêntrico de 1900 casos de pacientes portadores de neoplasias benignas e malignas da cabeça e do pescoço, atendidos e tratados no Centro de Oncologia do Hospital Universitário Oswaldo Cruz (CEON/HUOC/UPE, Hospital de C��ncer de Pernambuco (HCP e clínica privada, no período de abril de 1977 a abril de 2002 (25 anos. Comparam, ainda, os dados obtidos com a revisão bibliográfica realizada, bem como sua experiência pessoal na utilização de tal modalidade terapêutica. RESULTADOS: Do total de pacientes, 57,9% eram do sexo masculino e a quinta e sexta décadas de vida foram as mais frequentemente acometidas (58,9%. O Carcinoma basocelular foi o tipo histológico predominante (63,1% - 1200 casos, seguido dos hemangiomas (14,2% - 270 casos. O tempo médio de exposição das lesões ao nitrogênio líquido foi de 15 e 35 segundos, e o tempo médio de cicatrização de 14 e 21 dias para as lesões benignas e malignas respectivamente. CONCLUSÕES: A indicação da criocirurgia deve obedecer alguns critérios de avaliação como o aspecto macroscópico e tamanho da lesão, tipo histológico, localização, idade e perfil social de cada paciente. Quando indicada e executada corretamente, oferece idênticos índices de cura aos outros métodos terapêuticos convencionais.BACKGROUND: To demonstrate the authors’ experience on cryosurgery treatment for malignant and benign skin neoplasms on head , neck including mucosa. METHODS: The authors review a multicentric retrospective study of 1900 cases of patients with benign and malignant head and neck neoplasms attended and treated at CEON/HUOC/UPE, HCP and private clinic, from April 1977 to April 2002 (25 years. They also compare the data obtained with the literature

  16. Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el cauca, colombia

    OpenAIRE

    Sierra-Torres, Carlos H; Tafurt-Cardona, Yaliana; Acosta-Astaiza, Claudia P

    2012-01-01

    Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la firma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Po...

  17. Possible association between Carney complex and multiple endocrine neoplasia type 1 phenotypes

    OpenAIRE

    Nunes, Vânia dos Santos [UNESP; Chang, Cláudia V. [UNESP; Mazeto, Glaucia Maria Ferreira da Silva [UNESP; Marques, Mariângela Esther Alencar; Castro, Ana Valéria B; Nogueira, Célia Regina [UNESP

    2008-01-01

    Complexo de Carney (CNC) e neoplasia endócrina múltipla tipo 1 (MEN1) são formas de neoplasias endócrinas múltiplas de herança autossômica dominante. O diagnóstico do CNC ocorre quando dois critérios maiores (lentiginose, doença nodular pigmentosa primária das adrenais, mixomas cardíacos e cutâneos, acromegalia, neoplasia testicular, carcinoma de tireóide) são observados e/ou um critério maior associado a um critério suplementar (familiar afetado, mutação do gene PRKAR1A) ocorre. Por outro la...

  18. Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris

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    M.N. Al Hallak

    2009-09-01

    Full Text Available Oral isotretinoin is the drug of choice for severe acne vulgaris, but its use is still controversial in preventing, treating or stopping the progression of the cervical intraepithelial neoplasia [6–8]. It induces cell differentiation, inhibits cell proliferation, stimulates host immune reaction, inhibits the oncogene expression, augments cell-mediated cytotoxicity, and induces apoptosis [5]. The isotretinoin has many side effects including teratogenicity. There is no previous report of developing cervical intraepithelial neoplasia (CIN or vulvar intraepithelial neoplasia (VIN after introducing oral isotretinoin to a patient. We are reporting a 37-year-old female with no risk factors for cervical cancer who had developed CIN-I and VIN-I during a 6-month treatment period of oral isotretinoin for her severe acne vulgaris. Interestingly, the patient had complete spontaneous pathologic-proven remission after stopping the isotretinoin. Further case reports are warranted to support this incidence.

  19. Immunohistochemical localization of human papilloma virus in conjunctival neoplasias: A retrospective study

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    Sen Seema

    2007-01-01

    Full Text Available Background: The extent of association of human papilloma virus (HPV in human conjunctival neoplasias has been debated in studies originating from different parts of the world, but no substantial evidence has been generated on Indian subjects. This prompted us to carry out a retrospective study on conjunctival neoplasias diagnosed over the past 12 years. Materials and Methods: Histopathological and immunohistochemical analysis of 65 specimens of ocular neoplasias and 30 normal controls diagnosed between 1991 and 2002 at a tertiary eye care hospital, was undertaken. Formalin-fixed, paraffin-embedded tissues were reviewed for confirming histopathological diagnosis, presence of koilocytosis and changes related to actinic keratosis. Immunohistochemical analysis was done using HPV-specific monoclonal antibodies. Clinicopathological correlation and the association of HPV antigen with the histopathological features were performed. Results: Out of the 65 cases analyzed, 35 were papillomas and 30 were ocular surface squamous neoplasias (OSSN. The mean age was 48 years with a male preponderance. Histologically, koilocytosis was observed in 17.1% of papillomas and 36.6% of OSSN. Actinic keratosis was present in 33% of OSSN. Immunohistochemically 17.1% conjunctival papillomas stained positive for HPV antigen, all cases of OSSN were negative for HPV. There was no correlation between koilocytosis or actinic keratosis and the detection of HPV antigen. Conclusions: The association between HPV and conjunctival neoplasias is variable in different geographical areas and also depends on the methods of detection used. This study warrants the need for applying more advanced techniques at a molecular level to determine the possible etiology of HPV in conjunctival neoplasias among Asian-Indians.

  20. Immunohistochemical localization of human papilloma virus in conjunctival neoplasias: A retrospective study

    Science.gov (United States)

    Sharma, Anjana; Panda, Anita

    2007-01-01

    Background: The extent of association of human papilloma virus (HPV) in human conjunctival neoplasias has been debated in studies originating from different parts of the world, but no substantial evidence has been generated on Indian subjects. This prompted us to carry out a retrospective study on conjunctival neoplasias diagnosed over the past 12 years. Materials and Methods: Histopathological and immunohistochemical analysis of 65 specimens of ocular neoplasias and 30 normal controls diagnosed between 1991 and 2002 at a tertiary eye care hospital, was undertaken. Formalin-fixed, paraffin-embedded tissues were reviewed for confirming histopathological diagnosis, presence of koilocytosis and changes related to actinic keratosis. Immunohistochemical analysis was done using HPV-specific monoclonal antibodies. Clinicopathological correlation and the association of HPV antigen with the histopathological features were performed. Results: Out of the 65 cases analyzed, 35 were papillomas and 30 were ocular surface squamous neoplasias (OSSN). The mean age was 48 years with a male preponderance. Histologically, koilocytosis was observed in 17.1% of papillomas and 36.6% of OSSN. Actinic keratosis was present in 33% of OSSN. Immunohistochemically 17.1% conjunctival papillomas stained positive for HPV antigen, all cases of OSSN were negative for HPV. There was no correlation between koilocytosis or actinic keratosis and the detection of HPV antigen. Conclusions: The association between HPV and conjunctival neoplasias is variable in different geographical areas and also depends on the methods of detection used. This study warrants the need for applying more advanced techniques at a molecular level to determine the possible etiology of HPV in conjunctival neoplasias among Asian-Indians. PMID:17699945

  1. Candida and squamous (pre)neoplasia of immigrants and Dutch women as established in population-based cervical screening

    NARCIS (Netherlands)

    Vermeulen, C. F. W.; Verbruggen, B. S. M.; van Haaften, M.; Boon, M. E.; Heintz, A. P. M.

    2006-01-01

    The objective of this study was to establish the relationship between Candida vaginalis and (pre)neoplasia and the prevalence of Candida and (pre)neoplasia related to age and ethnicity. Data were collected from 445,671 asymptomatic women invited for mass screening between 1995 and 2002 and coded

  2. Malignant ilnesses in men breast. A twenty-five year study Afecciones malignas de la mama en hombre. Estudio de veinticinco años

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    Lidia Torres Ajá

    Full Text Available Background: Breast tumors prevailed in female population, nevertheless in male population appear although it is very infrequent to be found. Objective: to describe the clinical-pathologic behavior of breast cancer in Cienfuegos province. Method: A descriptive-retrospective study of breast tumors in males who were surgically treated at the University Hospital ";Dr. Gustavo Aldereguía Lima” in Cienfuegos, Cuba from January 1st 1981 to December 31st 2005. The variables used were the following: age, affected breast, topographic localization of the tumor, clinical stage at the time of diagnosis, histological variant, type of biopsy used for this purpose, surgical technique applied, and health area belonging to. Results: male breast cancer represented the 0.8 % out of the total of breast cancers which were surgically treated during this studied period. Detection at very advanced clinical stages was confirmed. Conclusions: It is necessary to establish mechanisms for their early detection due to the increment in the incidence of this disease in males.
    Fundamento: Los tumores mamarios prevalecen en la población femenina, sin embargo, en el sexo masculino, aunque es extremadamente infrecuente, también puede aparecer este tipo de afección. Objetivo: Describir el comportamiento clínico patológico del cáncer de mama en hombre, en la provincia Cienfuegos. Método: Se realizó un estudio descriptivo, retrospectivo, de todos los casos de tumores mamarios en hombre, operados en el Hospital Universitario ";Dr. Gustavo Aldereguía Lima” de Cienfuegos, desde el 1ro de enero de 1981, hasta el 31 de diciembre de 2005. Las variables analizadas fueron: edad, mama afectada, localización topográfica del tumor, etapa clínica en el momento del diagnóstico, variante histológica, tipo de biopsia

  3. Multiple endocrine neoplasia type 2A: a 25-year review.

    Science.gov (United States)

    Iler, M A; King, D R; Ginn-Pease, M E; O'Dorisio, T M; Sotos, J F

    1999-01-01

    Before 1970, treatment decisions for the thyroid lesions in patients with multiple endocrine neoplasia (MEN) were based on physical findings. For the next 20 years, biological markers assumed a preeminent role, and at present, DNA testing is being used to define the need for therapeutic intervention. This report presents a 25-year review of 22 children with MEN-2A, with a mean follow-up of 12.5 years. All 22 children underwent a total thyroidectomy, and four (18%) were rendered permanently hypoparathyroid. Since 1976, however, only one patient (6.7%) has lost parathyroid function. Despite the fact that biological screening studies routinely were performed once a year in the majority of our patients and surgery was recommended for any elevation in the serum calcitonin (CT) levels, medullary carcinoma of the thyroid (MTC) developed in 17 children (77%) and only five had C cell hyperplasia (CCH). Thirteen of the 17 had macroscopic tumor described by the pathologist, evidence of recurrent disease (MTC-REC) has developed in four children (24%). There was considerable overlap in both the basal and stimulated CT levels among the five children with CCH, the 13 with localized MTC (MTC-NED), and the four who later had recurrent MTC. The basal calcitonin levels were between 25 and 110 (mean, 58) in the CCH patients, 30 to 1,130 (mean, 184) in the MTC-NED group, and 108 to 201 (mean, 140) in those with recurrent MTC. The corresponding stimulated calcitonin levels were 45 to 417 (mean, 179) in CCH, 111 to 9,510 (mean, 1,407) in MTC-NED, and 449 to 5,093 (mean, 3,383) in MTC-REC. (1) Basal and pentagastrin-stimulated CT levels did not reliably discriminate between CCH and MTC and should not be used to define the timing of thyroid surgery in children with MEN-2A. (2) Surgical therapy should be undertaken early in childhood on the basis of molecular genetic testing. (3) Postoperative complications are infrequent in the modern era.

  4. Clinical and pathological heterogeneity of cervical intraepithelial neoplasia grade 3.

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    Hannah P Yang

    Full Text Available OBJECTIVE: Cervical intraepithelial neoplasia grade 3 (CIN3, the immediate cervical cancer precursor, is a target of cervical cancer prevention. However, less than half of CIN3s will progress to cancer. Routine treatment of all CIN3s and the majority of CIN2s may lead to overtreatment of many lesions that would not progress. To improve our understanding of CIN3 natural history, we performed a detailed characterization of CIN3 heterogeneity in a large referral population in the US. METHODS: We examined 309 CIN3 cases in the SUCCEED, a large population-based study of women with abnormal cervical cancer screening results. Histology information for 12 individual loop electrosurgical excision procedure (LEEP segments was evaluated for each woman. We performed case-case comparisons of CIN3s to analyze determinants of heterogeneity and screening test performance. RESULTS: CIN3 cases varied substantially by size (1-10 LEEP segments and by presentation with concomitant CIN2 and CIN1. All grades of CINs were equally distributed over the cervical surface. In half of the women, CIN3 lesions were found as multiple distinct lesions on the cervix. Women with large and solitary CIN3 lesions were more likely to be older, have longer sexual activity span, and have fewer multiple high risk HPV infections. Screening frequency, but not HPV16 positivity, was an important predictor of CIN3 size. Large CIN3 lesions were also characterized by high-grade clinical test results. CONCLUSIONS: We demonstrate substantial heterogeneity in clinical and pathological presentation of CIN3 in a US population. Time since sexual debut and participation in screening were predictors of CIN3 size. We did not observe a preferential site of CIN3 on the cervical surface that could serve as a target for cervical biopsy. Cervical cancer screening procedures were more likely to detect larger CIN3s, suggesting that CIN3s detected by multiple independent diagnostic tests may represent cases

  5. Diagnosis and surgical treatment of multiple endocrine neoplasia

    Institute of Scientific and Technical Information of China (English)

    ZHOU Guang-wen; WEI Yao; CHEN Xi; JIANG Xiao-hua; LI Xiao-ying; NING Guang; LI Hong-wei

    2009-01-01

    Background Multiple endocrine neoplasia (MEN) is relatively rare. But more patients could be found by detailed examination. We discuss the diagnosis and surgical treatment of MEN. Methods The clinical data of 95 MEN cases were retrospectively analyzed. There were 30 cases of MEN1 including 19 cases from 6 families. The MEN1 gene mutation was detected in 81.48% of cases admitted after 1997. There were 22 cases of primary hyperparathyroidism (PHPT), 10 cases of enteropanceatic tumor including 9 cases of insulinoma, 15 cases of pituitary adenoma, 9 cases of adrenal adenoma, 2 cases of thymic carcinoid. Two patients had 4 glands involved, 3 patients had 3 glands involved, 16 patients had 2 glands involved, and 6 patients had only one gland involved. Three patients had neither clinical symptoms nor biochemical changes, and was diagnosed by MEN1 gene mutation. Six patients presented with nephrolithasis and 6 patients had impaired pancreatic endocrine function. There were 60 cases of MEN2a and 5 cases of MEN2b. 58 cases of MEN2a belongs to 19 kindreds. All MEN2a patients but one presented RET gene mutation in codon 634, and all MEN2b cases had mutation in codon 918. 48 cases of MEN2a had thyroid masses with elevated calcitonin levels. 27 patients had pheochromocytoma including 12 cases of multiple loci and 5 malignancy. 13 patients presented with hyperparathyroidism. 5 MEN2b patients had medullary thyroid carcinoma and mucosal ganglioneuromatosis with Marfanoid. Among them, 3 patients had bilateral pheochromocytoma. Results In MEN1, subtotal parathyroidectomy was performed in 12 patients with PHPT and one patient received parathyroid adenoma enucleation. Insulinomas were enucleated in 4 patients. Two patients underwent thymus tumor extirpation. Total thyroidectomy with bilateral dissection of regional lymph nodes was performed in 16 patients with MEN2a and nodule enucleation was performed in 9 patients. Twenty two MEN2a patients underwent pheochromocytoma enucleation

  6. Heat shock protein90 in lobular neoplasia of the breast

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    Patsouris Efstratios

    2008-10-01

    Full Text Available Abstract Background Heat shock protein 90 (Hsp90 overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications. The purpose of this study is to evaluate the immunohistochemical expression of Hsp90 and to examine whether Hsp90 expression is associated with estrogen receptor alpha (ER-alpha and beta (ER-beta immunostaining in lobular neoplasia (LN of the breast. Methods Tissue specimens were taken from 44 patients with LN. Immunohistochemical assessment of Hsp90, ER-alpha and ER-beta was performed both in the lesion and the adjacent normal breast ducts and lobules; the latter serving as control. As far as Hsp90 evaluation is concerned: i the percentage of positive cells, and ii the intensity was separately analyzed. Additionally, the Allred score was adopted and calculated. Accordingly, Allred score was separately evaluated for ER-alpha and ER-beta. The intensity was treated as an ordinal variable-score (0: negative, low: 1, moderate: 2, high: 3. Statistical analysis followed. Results Hsp90 immunoreactivity was mainly cytoplasmic in both the epithelial cells of normal breast (ducts and lobules and LN. Some epithelial cells of LN also showed nuclear staining, but all the LN foci mainly disclosed a positive cytoplasmic immunoreaction for Hsp90. In addition, rare intralobular inflammatory cells showed a slight immunoreaction. The percentage of Hsp90 positive cells in the LN areas was equal to 67.1 ± 12.2%, whereas the respective percentage in the normal adjacent breast tissue was 69.1 ± 11.6%; the difference was not statistically significant. The intensity score of Hsp90 staining was 1.82 ± 0.72 in LN foci, while in the normal adjacent tissue the intensity score was 2.14 ± 0.64. This difference was statistically significant (p = 0.029, Wilcoxon matched-pairs signed-ranks test. The Hsp90 Allred score was 6.46 ± 1.14 in the LN foci, significantly lower than in the normal adjacent tissue (6.91

  7. Pathogenesis and Active Prevention of Testicular Germ Cell Neoplasia

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    Slowikowska-Hilczer J

    2007-01-01

    Full Text Available Most testicular neoplasms originate from fetal germ cells (germ cell tumors [GCT]. Intratubular germ cell neoplasia (ITGCN or testicular carcinoma in situ (CIS are terms used for the state when these cells are present in the seminiferous epithelium. The highest risk of neoplastic lesions occurs in testes with disturbed organogenesis (in our study, 65 %. Genetic, hormonal, and environmental factors are suspected to lead to disturbed testicular organogenesis (dysgenesis, which creates the milieu favorable for GCT development. An external environment can cause a block or delay in fetal germ and somatic cell differentiation. CIS cells in dysgenetic testes of children reveal a predominantly aneuploid DNA pattern (62.2–97.6 % of germ cells and they do not express an RBM protein (present in normal germ cells, this indicates that CIS cells are neoplastic from fetal life on. Most of the neoplastic germ cells die, however, some survive and proliferate, leading to a clonal expansion and giving rise to gonadoblastoma, CIS, and GCT. Neoplastic germ cells located inside underdeveloped testicular tubules have an intratesticular environment favorable for their survival – this was confirmed by the finding that the highest incidence of neoplastic lesions occurred in patients with partial (90.9 % and mixed gonadal dysgenesis (76.9 %. It was hypothesized that the transformation of CIS into overt GCT may be promoted by gonadotropin action. We found that in gonadal dysgenesis, serum concentrations of FSH and LH reveal highly significant, positive correlations with the number of CIS cells, even in childhood. At present, surgical biopsy of the testis is the only reliable method to detect CIS and hence to actively prevent the development of overt GCT. Accordingly, early bilateral gonadectomy is recommended in all types of disturbance of testicular organogenesis because of the high risk of various neoplastic lesions in dysgenetic testes (86 % of adult patients with

  8. Current treatment options for management of anal intraepithelial neoplasia

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    Weis SE

    2013-06-01

    Full Text Available Stephen E Weis1,2 1Division of Dermatology, Department of Internal Medicine, University of North Texas Health Science Center at Fort Worth, 2Preventive Medicine Clinic, Tarrant County Public Health, Fort Worth, TX, USA Abstract: Anal squamous cell cancer is an uncommon malignancy caused by infection with oncogenic strains of Human papilloma virus. Anal cancer is much more common in immunocompromised persons, including those infected with Human immunodeficiency virus. High-grade anal intraepithelial neoplasia (HGAIN, the precursor of anal cancer, is identified by clinicians providing care for patients with anorectal disease, and is increasingly being identified during screening of immunosuppressed patients for anal dysplasia. The traditional treatment for HGAIN has been excision of macroscopic disease with margins. This approach is effective for patients with small unifocal HGAIN lesions. Patients with extensive multifocal HGAIN frequently have recurrence of HGAIN after excision, and may have postoperative complications of anal stenosis or fecal incontinence. This led to the suggestion by some that treatment for HGAIN should be delayed until patients developed anal cancer. Alternative approaches in identification and treatment have been developed to treat patients with multifocal or extensive HGAIN lesions. High-resolution anoscopy combines magnification with anoscopy and is being used to identify HGAIN and determine treatment margins. HGAIN can then be ablated with a number of modalities, including infrared coagulation, CO2 laser, and electrocautery. These methods for HGAIN ablation can be performed with local anesthesia on outpatients and are relatively well tolerated. High-resolution anoscopy-directed HGAIN ablation is evolving into a standard approach for initial treatment and then subsequent monitoring of a disease which should be expected to be recurrent. Another treatment approach for HGAIN is topical treatment, principally with 5

  9. Estudo comparativo de indicadores nutricionais em pacientes com neoplasias do trato digestório

    OpenAIRE

    Leandro-Merhi, Vânia Aparecida; Tristão, Ana Paula; Moretto,Maria Clara; Fugulin, Natália Maria; Portero-McLellan,Kátia Cristina; AQUINO,José Luiz Braga de

    2008-01-01

    RACIONAL: O câncer tem sido considerado atualmente como um dos principais problemas de saúde pública em todo o mundo e os tumores mais frequentes são os dos tratos gastrintestinal e o respiratório. OBJETIVO: Comparar indicadores do estado nutricional em pacientes portadores de neoplasias do trato digestório. MÉTODO: Estudo comparativo de indicadores nutricionais (antropométricos, laboratoriais e dietéticos), entre 28 pacientes portadores de neoplasias do trato digestório (esofágicas, gástrica...

  10. Risk of Advanced Neoplasia Using the National Cancer Institute's Colorectal Cancer Risk Assessment Tool.

    Science.gov (United States)

    Imperiale, Thomas F; Yu, Menggang; Monahan, Patrick O; Stump, Timothy E; Tabbey, Rebeka; Glowinski, Elizabeth; Ransohoff, David F

    2017-01-01

    There is no validated, discriminating, and easy-to-apply tool for estimating risk of colorectal neoplasia. We studied whether the National Cancer Institute's (NCI's) Colorectal Cancer (CRC) Risk Assessment Tool, which estimates future CRC risk, could estimate current risk for advanced colorectal neoplasia among average-risk persons. This cross-sectional study involved individuals age 50 to 80 years undergoing first-time screening colonoscopy. We measured medical and family history, lifestyle information, and physical measures and calculated each person's future CRC risk using the NCI tool's logistic regression equation. We related quintiles of future CRC risk to the current risk of advanced neoplasia (sessile serrated polyp or tubular adenoma ≥ 1 cm, a polyp with villous histology or high-grade dysplasia, or CRC). All statistical tests were two-sided. For 4457 (98.5%) with complete data (mean age = 57.2 years, SD = 6.6 years, 51.7% women), advanced neoplasia prevalence was 8.26%. Based on quintiles of five-year estimated absolute CRC risk, current risks of advanced neoplasia were 2.1% (95% confidence interval [CI] = 1.3% to 3.3%), 4.8% (95% CI = 3.5% to 6.4%), 6.4% (95% CI = 4.9% to 8.2%), 10.0% (95% CI = 8.1% to 12.1%), and 17.6% (95% CI = 15.5% to 20.6%; P < .001). For quintiles of estimated 10-year CRC risk, corresponding current risks for advanced neoplasia were 2.2% (95% CI = 1.4% to 3.5%), 4.8% (95% CI = 3.5% to 6.4%), 6.5% (95% CI = 5.0% to 8.3%), 9.3% (95% CI = 7.5% to 11.4%), and 18.4% (95% CI = 15.9% to 21.1%; P < .001). Among persons with an estimated five-year CRC risk above the median, current risk for advanced neoplasia was 12.8%, compared with 3.7% among those below the median (relative risk = 3.4, 95 CI = 2.7 to 4.4). The NCI's Risk Assessment Tool, which estimates future CRC risk, may be used to estimate current risk for advanced neoplasia, making it potentially useful for tailoring and improving CRC

  11. The prognostic significance of virus-associated changes in grade 1 cervical intra-epithelial neoplasia

    DEFF Research Database (Denmark)

    Bagi, P; Worning, A M; Nordsten, M

    1987-01-01

    patients the treatment was unsuccessful (persistence, recurrence, or progression of the neoplasia). The frequency of treatment failure was 33% in patients with, and 10% in patients without virus-associated changes (p less than 0.025). It is recommended that patients with CIN 1 and virus-associated changes......Virus-associated changes of the cervix uteri were assessed in patients treated for grade 1 cervical intra-epithelial neoplasia (CIN). Of 106 patients evaluated, 67 (63%) had virus-associated changes. The patients were treated without regard to the presence/absence of virus-associated changes. In 26...... should, after initial treatment, be followed-up with increased attention....

  12. Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina Neuroleptic malignant syndrome: case report of a recurrence related to olanzapine

    Directory of Open Access Journals (Sweden)

    RICARDO A. HANEL

    1998-12-01

    Full Text Available A síndrome neuroléptica maligna (SNM consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de dopamina.A SNM é caracterizada por hiperpirexia, alteração do nível de consciência, hipertonia, disfunção autonômica e insuficiência respiratória, podendo ainda ser encontrados rabdomiólise e leucocitose. O haloperidol é a droga mais frequentemente associada à síndrome. Relatamos o caso de um paciente de 30 anos que apresentou SNM em duas ocasiões diferentes, a primeira delas relacionada ao uso de haloperidol e clorpromazina e a segunda relacionada ao uso de olanzapina, fato este sem menção anterior na literatura indexada.The neuroleptic malignant syndrome (NMS consists in an idiosyncratic reaction to neuroleptic drugs, probably related to a blockage of dopamine receptors in basal ganglia. Research criteria for diagnosing NMS from DSM-IV require severe rigidity and fever accompanied by 2 of 10 minor features including diaphoresis, dysphagia, tremor, incontinence, altered mentation, mutism, tachycardia, elevated or labile blood pressure, leukocytosis and elevation of creatine phosphokinase. From a clinical point of view, the NMS may range a large spectrum of presentations. Haloperidol is the most frequent drug associated with this syndrome. We report the case of a 30 year-old man who developed NMS at two different occasions, the first related to haloperidol and chlorpromazine and the second related to olanzapine, to our knowledge without previous mention in the indexed literature.

  13. Biopsia de médula ósea: Patrones morfológicos de las hemopatías y tumores sólidos en pediatría

    Directory of Open Access Journals (Sweden)

    Alma Torres Gómez de Cádiz Silva

    1996-12-01

    Full Text Available Se presentan los resultados del estudio de 165 biopsias de médula ósea realizadas a pacientes ingresados en el Hospital Pediátrico Docente "Juan Manuel Márquez". Las distintas afecciones que motivaron las biopsias fueron: enfermedades hematológicas no malignas, 56 casos; leucemia linfoblástica aguda, 9 casos; leucemia mieloide crónica juvenil, 2 casos; histiocitosis maligna, 1 caso; linfoma no Hodgkin, 25 casos; enfermedad de Hodgkin, 31 casos; neuroblastoma, 13 casos; sarcoma de partes blandas, 11 casos; neuroblastoma, 13 casos; evaluación del órgano posquimioterapia, 17 casos. Se describen las características morfológicas de la médula ósea en diferentes hemopatías y los patrones de infiltración de las leucemias y los tumores sólidos más frecuentes en el niño.The results of the study of 165 bone marrow biopsias performed to patients admitted in the "Juan Manuel Márquez" Pediatric Teaching Hospital, are presented. The different affections leading to biopsies were: non-malignant hematologic diseases, 56 cases; acute lymphoblastic leukemia, 9 cases; juvenile chronic myeloid leukemia, 2 cases; malignant histiocytosis, 1 case; non-Hodgking lymphoma, 25 cases; Hodgkin's disease, 31 cases, neuroblastoma, 13 cases; soft tissues sarcomas, 11 cases; and, postchemiotherapy organ evaluation, 17 cases. The morphological characteristics of the bone marrow in different hemopathies, as well as the infiltration patterns of leukemias and of the most common solid tumours in children, are described.

  14. Secuelas Endocrinológicas del Tratamiento de las Enfermedades Oncológicas en la Infancia y Adolescencia

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available Los avances en el tratamiento de las enfermedades oncológicas en la infancia y adolescencia han permitido que la tasa de sobrevida en niños tratados por cáncer aumente progresivamente. Alrededor del 70% de los pacientes pediátricos tratados por tumores del SNC, el 80% por leucemias linfoblásticas agudas y más del 90% por linfoma de Hodgkin sobreviven a los mismos. Los trastornos endocrinos de los diferentes ejes se observan en un alto porcentaje de los sobrevivientes, debido a afecciones producidas por la enfermedad de base, el tratamiento o intercurrencias. Muchas de estas anomalías pueden sobrevenir años o décadas luego del tratamiento. La terapéutica de estas enfermedades comprende diferentes esquemas incluyendo cirugía, quimioterapia y radioterapia. Estos intensos esquemas de tratamiento pueden tener como consecuencia la aparición de diversas secuelas; 40% de los pacientes tratados por enfermedades oncológicas en la infancia va a tener alguna secuela endocrina relacionada con la enfermedad de base, la cirugía, la radio y/o quimioterapia; dependiente de la edad al inicio de la enfermedad y/o tratamiento, el género y el tiempo transcurrido desde la finalización del tratamiento. Postradioterapia craneal el orden de alteración de los ejes es 1 eje somatotrófico, 2 eje gonadotrófico, 3 eje adrenocorticotrófico y 4 eje tiroideo. La radio y quimioterapia pueden producir daño gonadal primario siendo el epitelio germinal del varón el más susceptible. La recuperación a medida que se aleja de la finalización del tratamiento es infrecuente, pero posible. Es de suma importancia conocer las posibles alteraciones con el objeto de realizar un adecuado control de los pacientes, durante su infancia y adolescencia y en la vida adulta. Con este fin se recomienda: • Una observación semestral del crecimiento y desarrollo puberal, en todos los niños tratados por neoplasia maligna, hasta que alcancen su estatura adulta y completen su

  15. Neoplasia escamosa de la superficie ocular en pacientes con pterigión en Perú

    Directory of Open Access Journals (Sweden)

    Luis Furuya-Kanamori

    Full Text Available Objetivos. Estimar la frecuencia de neoplasia escamosa de la superficie ocular (NESO no sospechada en pterigión, la precisión del diagnóstico clínico y las características demográficas y clínicas asociadas. Materiales y métodos. Se examinaron los informes histopatológicos de los pacientes con diagnóstico clínico de pterigión y/o NESO que fueron quirúrgicamente tratados entre marzo de 2009 y diciembre de 2012 en el Instituto Nacional de Oftalmología en Lima, Perú. La precisión del diagnóstico clínico para identificar la NESO se evaluó mediante la sensibilidad, especificidad y los cocientes de probabilidad. Se realizaron modelos de regresión log-log negativos para identificar las características demográficas y clínicas asociadas con un aumento de las probabilidades de diagnosticar NESO. Resultados. Se examinaron 3021 informes de histopatología. La frecuencia de NESO no sospechada en pterigión fue de 0,65%. El diagnóstico clínico presentó una sensibilidad del 85%, una especificidad del 99%, un cociente de probabilidad positiva de 111,89 y un cociente probabilidad negativa de 0,15. Las características asociadas fueron el sexo masculino (OR 1,15; IC 95%:1,01-1,30, pacientes de 61 a 80 años (OR 1,54; IC 95%: 1,28-1,85, ≥ de 81 años (OR 3,10; IC 95%: 2,09-4,58, pacientes con lesiones recurrentes (OR 1,59; IC 95%: 1,03-2,46 y lesiones en el lado temporal (OR 3,57; IC 95%: 2,63-4,85 presentaron mayor probabilidad de NESO. Conclusiones. Se encontró una baja frecuencia de NESO no sospechada, sin embargo, es recomendable realizar el estudio histopatológico de forma rutinaria para evitar diagnósticos erróneos de NESO como pterigión.

  16. Marcadores de riesgo de neoplasia folicular en nódulos tiroideos Risk markers of follicular neoplasms in thyroid nodules

    Directory of Open Access Journals (Sweden)

    Marcelo Monteros Alvi

    2009-10-01

    Full Text Available Los nódulos tiroideos de origen folicular abarcan procesos no neoplásicos y neoplásicos. No existen métodos de diagnóstico ni rasgos citológicos por punción con aguja fina (PAF que los delimiten, constituyendo un dilema su diagnóstico diferencial. Analizamos la asociación existente entre variables clínicas y métodos de diagnóstico prequirúrgicos en nódulos tiroideos de estirpe folicular, con el objetivo de definir riesgo de neoplasia.Se estudiaron 92 pacientes con bocios nodulares de estirpe folicular por citología, tratados con tiroidectomía. Las variables analizadas fueron: sexo, edad, tamaño del nódulo, características ecográficas, diagnóstico citológico, nivel de TSH y resultados del centellograma. De los 92 casos, 74 fueron neoplásicos (56 adenomas y 18 carcinomas diferenciados y 18 nódulos no neoplásicos, hiperplásicos o adenomatosos. Los marcadores que se relacionaron con alto riesgo de neoplasia folicular correspondieron al diagnóstico citológico de proliferación folicular de alto grado, en nódulos iso o hipoecogénicos, e hipocaptantes con I131. Los carcinomas presentaron citología de proliferación folicular de alto grado en nódulos hipoecogénicos, de bordes irregulares con microcalcificaciones e hipocaptantes, en pacientes varones o menores de 20 años. La presencia de macrocalcificaciones e hipercaptación estarían a favor de nódulo de origen benigno.La correlación de los métodos de diagnóstico y variables clínicas en nódulos tiroideos de estirpe folicular nos permitirían delimitar el riesgo de neoplasia y carcinoma para planificar un tratamiento quirúrgico selectivo.Thyroid nodules of follicular origin include neoplastic and non neoplastic processes. No methods of diagnosis or cytological features (obtained by fine-needle aspiration, FNA may differentiate both types, and therefore differential diagnosis still constitutes a dilemma.We analyzed the existing association between clinical

  17. Endoscopic submucosal dissection for early esophageal neoplasia: A single center experience in South Taiwan

    Directory of Open Access Journals (Sweden)

    Ching-Tai Lee

    2012-03-01

    Conclusion: ESD is a promising local curative treatment option for early esophageal neoplasia in Taiwan. However, this procedure may result in complications that are worth noting, especially post-ESD esophageal stricture. Education regarding this procedure and more hands-on training will facilitate endoscopists to improve the outcomes of patients undergoing this procedure.

  18. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

    NARCIS (Netherlands)

    Srigley, J.R.; Delahunt, B.; Eble, J.N.; Egevad, L.; Epstein, J.I.; Grignon, D.; Hes, O.; Moch, H.; Montironi, R.; Tickoo, S.K.; Zhou, M.; Argani, P.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group p

  19. Surgical approach in patients with hyperparathyroidism in multiple endocrine neoplasia type 1: total versus partial parathyroidectomy

    Directory of Open Access Journals (Sweden)

    Francesco Tonelli

    2012-01-01

    Full Text Available Usually, primary hyperparathyroidism is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1, and is also the most common one. The timing of the surgery and strategy in multiple endocrine neoplasia type 1/hyperparathyroidism are still under debate. The aims of surgery are to: 1 correct hypercalcemia, thus preventing persistent or recurrent hyperparathyroidism; 2 avoid persistent hypoparathyroidism; and 3 facilitate the surgical treatment of possible recurrences. Currently, two types of surgical approach are indicated: 1 subtotal parathyroidectomy with removal of at least 3-3 K glands; and 2 total parathyroidectomy with grafting of autologous parathyroid tissue. Transcervical thymectomy must be performed with both of these procedures. Unsuccessful surgical treatment of hyperparathyroidism is more frequently observed in multiple endocrine neoplasia type 1 than in sporadic hyperparathyroidism. The recurrence rate is strongly influenced by: 1 the lack of a pre-operative multiple endocrine neoplasia type 1 diagnosis; 2 the surgeon's experience; 3 the timing of surgery; 4 the possibility of performing intra-operative confirmation (histologic examination, rapid parathyroid hormone assay of the curative potential of the surgical procedure; and, 5 the surgical strategy. Persistent hyperparathyroidism seems to be more frequent after subtotal parathyroidectomy than after total parathyroidectomy with autologous graft of parathyroid tissue. Conversely, recurrent hyperparathyroidism has a similar frequency in the two surgical strategies. To plan further operations, it is very helpful to know all the available data about previous surgery and to undertake accurate identification of the site of recurrence.

  20. Post-surgical follow-up of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1

    Directory of Open Access Journals (Sweden)

    Flavia L. Coutinho

    2012-01-01

    Full Text Available The bone mineral density increments in patients with sporadic primary hyperparathyroidism after parathyroidectomy have been studied by several investigators, but few have investigated this topic in primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Further, as far as we know, only two studies have consistently evaluated bone mineral density values after parathyroidectomy in cases of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Here we revised the impact of parathyroidectomy (particularly total parathyroidectomy followed by autologous parathyroid implant into the forearm on bone mineral density values in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Significant increases in bone mineral density in the lumbar spine and femoral neck values were found, although no short-term (15 months improvement in bone mineral density at the proximal third of the distal radius was observed. Additionally, short-term and medium-term calcium and parathyroid hormone values after parathyroidectomy in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 are discussed. In most cases, this surgical approach was able to restore normal calcium/parathyroid hormone levels and ultimately lead to discontinuation of calcium and calcitriol supplementation.

  1. Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study

    NARCIS (Netherlands)

    Eijsink, J. J. H.; Yang, N.; Lendvai, A.; Klip, H. G.; Volders, H. H.; Buikema, H. J.; van Hemel, B. M.; Voll, M.; Bennink, H. J. T. Coelingh; Schuuring, E.; Wisman, G. B. A.; van der Zee, A. G. J.

    2011-01-01

    Objective. To explore the feasibility of DNA methylation analysis for the detection of cervical neoplasia in self-obtained cervico-vaginal lavages. Methods. Lavages collected by a self-sampling device and paired cervical scrapings were obtained from 20 cervical cancer patients and 23 patients referr

  2. Natural history of high-grade cervical intraepithelial neoplasia : a review of prognostic biomarkers

    NARCIS (Netherlands)

    Koeneman, Margot M.; Kruitwagen, Roy F. P. M.; Nijman, Hans W.; Slangen, Brigitte F. M.; Van Gorp, Toon; Kruse, Arnold-Jan

    2015-01-01

    The natural history of high-grade cervical intraepithelial neoplasia (CIN) is largely unpredictable and current histopathological examination is unable to differentiate between lesions that will regress and those that will not. Therefore, most high-grade lesions are currently treated by surgical exc

  3. Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®)—Health Professional Version

    Science.gov (United States)

    Expert-reviewed information summary about the genetics of endocrine and neuroendocrine neoplasias. This summary contains information about the MEN1 gene, the RET gene, genetic testing, and clinical interventions. Psychosocial issues associated with genetic testing and counseling of individuals who may have a hereditary medullary thyroid cancer syndrome are also discussed.

  4. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

    NARCIS (Netherlands)

    J. Burn (John); D.T. Bishop (David Timothy); J.-P. Mecklin (Jukka-Pekka); F.A. Macrae (Finlay); G. Möslein (Gabriela); S. Olschwang (Sylviane); M.-L. Bisgaard (Marie-Luise); R.S. Ramesar (Rajkumar); D. Eccles (Diana); E.R. Maher (Eamonn); L. Bertario (Lucio); H.J. Jarvinen (Heikki); A. Lindblom (Annika); D.G. Evans (Gareth); J. Lubinski (Jan); P.J. Morrison (Patrick); J.W.C. Ho (Judy); H. Vasen (Hans); L. Side (Lucy); H.J.W. Thomas (Huw ); R.J. Scott (Rodney); M.G. Dunlop (Malcolm); G. Barker (Gail); F. Elliott (Faye); J.R. Jass (Jeremy ); R. Fodde (Riccardo); H. Lynch (Henry); J.C. Mathers (John )

    2008-01-01

    textabstractBACKGROUND: Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplas

  5. A rare presentation of multiple endocrine neoplasia (MEN type 2A syndrome

    Directory of Open Access Journals (Sweden)

    Elroy Patrick Weledji

    2016-02-01

    Full Text Available Peptic ulcer disease may be a manifestation of symptomatic primary hyperparathyroidism. A case of an intractable complicated peptic ulcer disease secondary to hypercalcaemia from multiple endocrine neoplasia type 2A is presented. Hypercalcaemia should always be excluded as a cause of recurrent, or complicated peptic ulcer disease.

  6. Linear regression of postevacuation serum human chorionic gonadotropin concentrations predicts postmolar gestational trophoblastic neoplasia

    NARCIS (Netherlands)

    Lybol, C.; Sweep, F.C.; Ottevanger, P.B.; Massuger, L.F.A.G.; Thomas, C.M.G.

    2013-01-01

    OBJECTIVE: Currently, human chorionic gonadotropin (hCG) follow-up after evacuation of hydatidiform moles is essential to identify patients requiring chemotherapeutic treatment for gestational trophoblastic neoplasia (GTN). We propose a model based on linear regression of postevacuation serum hCG co

  7. Risk of cervical cancer after completed post-treatment follow-up of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Rebolj, Matejka; Helmerhorst, Theo; Habbema, Dik;

    2012-01-01

    To compare the risk of cervical cancer in women with histologically confirmed cervical intraepithelial neoplasia who returned to routine screening after having completed post-treatment follow-up with consecutive normal smear test results with women with a normal primary smear test result....

  8. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia

    NARCIS (Netherlands)

    Visser, J.; Nijman, H. W.; Hoogenboom, B.-N.; Jager, P.; van Baarle, D.; Schuuring, E.; Abdulahad, W.; Miedema, F.; van der Zee, A. G.; Daemen, T.

    2007-01-01

    Oncogenic human papillomavirus (HPV)-infection is crucial for developing cervical cancer and its precursor lesions [cervical intraepithelial neoplasia (CIN)]. Regulatory T cells (T-regs) might be involved in the failure of the immune system to control the development of HPV-induced cancer. We

  9. Local recurrence of pheochromocytoma in multiple endocrine neoplasia type 2A: a diagnostic and therapeutic challenge

    OpenAIRE

    Tramunt, Blandine; Buffet, Alexandre; Grunenwald, Solange; Vezzosi, Delphine; Bennet, Antoine; Huyghe, Eric; Zerdoud, Slimane; Caron, Philippe

    2016-01-01

    Key Clinical Message In a patient with multiple endocrine neoplasia type 2A (MEN2A), an inverted physiological ratio between urinary normetanephrines and metanephrines is an early marker of recurrence in epinephrine?secreting pheochromocytoma, and 131I MIBG treatment appears to be a useful therapeutic option in order to avoid multiple invasive surgical procedures in pheochromocytomatosis.

  10. Local recurrence of pheochromocytoma in multiple endocrine neoplasia type 2A: a diagnostic and therapeutic challenge.

    Science.gov (United States)

    Tramunt, Blandine; Buffet, Alexandre; Grunenwald, Solange; Vezzosi, Delphine; Bennet, Antoine; Huyghe, Eric; Zerdoud, Slimane; Caron, Philippe

    2016-03-01

    In a patient with multiple endocrine neoplasia type 2A (MEN2A), an inverted physiological ratio between urinary normetanephrines and metanephrines is an early marker of recurrence in epinephrine-secreting pheochromocytoma, and 131I MIBG treatment appears to be a useful therapeutic option in order to avoid multiple invasive surgical procedures in pheochromocytomatosis.

  11. Diagnosis and Management of Multiple Endocrine Neoplasia Type 1 (MEN1)

    NARCIS (Netherlands)

    Dreijerink, Koen M. A.; Lips, Cees J. M.

    2005-01-01

    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited disorder, characterised by the occurrence of tumours of the parathyroid glands, the pancreatic islets, the pituitary gland, the adrenal glands and neuroendocrine carcinoid tumours. Carcinoid tumours of the thymus and pan

  12. Adenomas in Patients with Inflammatory Bowel Disease Are Associated with an Increased Risk of Advanced Neoplasia

    NARCIS (Netherlands)

    Schaik, F.D. van; Mooiweer, E.; Have, M. van der; Belderbos, T.D.; Kate, F.J. ten; Offerhaus, G.J.; Schipper, M.E.; Dijkstra, G.; Pierik, M.; Stokkers, P.C.; Ponsioen, C.; Jong, D.J. de; Hommes, D.W.; Bodegraven, A.A. van; Siersema, P.D.; Oijen, M.G.H. van; Oldenburg, B.

    2013-01-01

    BACKGROUND:: It is still unclear whether inflammatory bowel disease (IBD) patients with adenomas have a higher risk of developing high-grade dysplasia (HGD) or colorectal cancer (CRC) than non-IBD patients with sporadic adenomas. We compared the risk of advanced neoplasia (AN, defined as HGD or CRC)

  13. Adenomas in Patients with Inflammatory Bowel Disease Are Associated with an Increased Risk of Advanced Neoplasia

    NARCIS (Netherlands)

    van Schaik, Fiona D. M.; Mooiweer, Erik; van der Have, Mike; Belderbos, Tim D. G.; ten Kate, Fiebo J. W.; Offerhaus, G. Johan A.; Schipper, Marguerite E. I.; Dijkstra, Gerard; Pierik, Marieke; Stokkers, Pieter C. F.; Ponsioen, Cyriel; de Jong, Dirk J.; Hommes, Daniel W.; van Bodegraven, Ad A.; Siersema, Peter D.; van Oijen, Martijn G. H.; Oldenburg, Bas

    2013-01-01

    Background: It is still unclear whether inflammatory bowel disease (IBD) patients with adenomas have a higher risk of developing high-grade dysplasia (HGD) or colorectal cancer (CRC) than non-IBD patients with sporadic adenomas. We compared the risk of advanced neoplasia (AN, defined as HGD or CRC)

  14. New insights into inflammatory bowel disease and colitis-associated neoplasia

    NARCIS (Netherlands)

    van Schaik, F.D.M.

    2012-01-01

    This thesis describes new insights into the development of inflammatory bowel disease (IBD: ulcerative colitis (UC) or Crohn’s disease (CD)) and IBD-associated neoplasia. In the first part, the value of serological markers as predictors of IBD was investigated in a large European cohort of individua

  15. Von Hippel-Lindau Disease : Genetics and role of genetic counseling in a multiple neoplasia syndrome

    NARCIS (Netherlands)

    Nielsen, Sarah M; Rhodes, Lindsay; Blanco, Ignacio; Chung, Wendy K; Eng, Charis; Maher, Eamonn R; Richard, Stéphane; Giles, Rachel H

    2016-01-01

    Von Hippel-Lindau disease (VHL) is one of the most common inherited neoplasia syndromes and is characterized by highly vascular tumors of the eyes, brain, and spine, as well as benign and malignant tumors and/or cysts of the kidneys, adrenal medullae and sympathetic paraganglia, endolymphatic sac, e

  16. Disparities in the Clinical Evolution of Anal Neoplasia in an HIV-Infected Cohort.

    Science.gov (United States)

    Cachay, Edward R; Agmas, Wollelaw; Christopher Mathews, Wm

    2017-03-23

    A recent meta-analysis suggested that anal intraepithelial neoplasia and invasive anal cancer are more prevalent among black men having sex with men (MSM). We conducted a retrospective cohort of HIV-infected adult patients under care between 2001 and 2012. Disparities in clinical evolution of anal intraepithelial neoplasia to high-grade squamous intraepithelial lesion (HSIL) and invasive anal cancer were evaluated in a three-state Markov model adjusted for cytology misclassification. We studied sociodemographic covariate effects for each state transition using multivariable models controlling for antiretroviral therapy and infrared coagulation treatment of HSIL. Among 2804 patients with a median age of 40 years, 78% were MSM and 38% non-white. There were no disparities in HSIL prevalence (14%) by age, sex, race, or risk group. After 4.0 years of follow-up, 23 patients developed invasive anal cancer. Females and black patients had lower transition rates from 40 had lower rates of both anal intraepithelial neoplasia nor with post-baseline progression of anal intraepithelial neoplasia.

  17. Characteristics of the Danish families with multiple endocrine neoplasia type 1

    DEFF Research Database (Denmark)

    2006-01-01

    Multiple endocrine neoplasia type 1 (MEN1) is caused by autosomal dominantly inherited mutations in the MEN1 gene. Here, we report 25 MEN1 mutations - of which 12 are novel - found in 36 Danish families with MEN1 or variant MEN1 disease. Furthermore, one FIHP family was found to have an earlier r...

  18. 3-GROUP METAPHASE AS A MORPHOLOGIC CRITERION OF PROGRESSIVE CERVICAL INTRAEPITHELIAL NEOPLASIA

    NARCIS (Netherlands)

    MOURITS, MJE; PIETERS, WJLM; HOLLEMA, H; BURGER, MPM

    1992-01-01

    OBJECTIVE: The purpose of our study was to investigate the presence of three-group metaphase in progressive cervical intraepithelial neoplasia. STUDY DESIGN: This was a retrospective histologic study on the conization specimens of 41 women with microinvasive cervical carcinoma, 28 of whom were enrol

  19. Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark

    DEFF Research Database (Denmark)

    Mathiesen, Jes Sloth; Kroustrup, Jens Peter; Vestergaard, Peter

    2017-01-01

    Extract: Multiple endocrine neoplasia 2B (MEN2B) is an autosomal dominant inherited cancer syndrome associating medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO), ganglioneuromatosis of the aerodigestive tract and facial, ophthalmologic and skeletal abnormalities. MEN2B is caused by the M...

  20. Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study

    NARCIS (Netherlands)

    Eijsink, J. J. H.; Yang, N.; Lendvai, A.; Klip, H. G.; Volders, H. H.; Buikema, H. J.; van Hemel, B. M.; Voll, M.; Bennink, H. J. T. Coelingh; Schuuring, E.; Wisman, G. B. A.; van der Zee, A. G. J.

    Objective. To explore the feasibility of DNA methylation analysis for the detection of cervical neoplasia in self-obtained cervico-vaginal lavages. Methods. Lavages collected by a self-sampling device and paired cervical scrapings were obtained from 20 cervical cancer patients and 23 patients

  1. A hypothesis to relate salivary tumors with mammary and prostate neoplasias.

    Science.gov (United States)

    Actis, Adriana B

    2005-04-21

    Salivary, mammary and prostate glands are sex hormone-dependent organs sharing common aspects in structure, hormonal responsiveness and tumor histopathology. Salivary tumors (especially the malignant types) are not as frequent as mammary and prostate neoplasias. Hence, prognosis of some salivary tumors is not always efficient. Here, we review the oncology of salivary gland and its putative relation to breast/prostate tumors.

  2. No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

    NARCIS (Netherlands)

    Nell, Sjoerd; van Leeuwaarde, Rachel S; Pieterman, Carolina R C; de Laat, Joanne M; Hermus, Ad R; Dekkers, Olaf M; de Herder, Wouter W; van der Horst-Schrivers, Anouk N; Drent, Madeleine L; Bisschop, Peter H; Havekes, Bas; Borel Rinkes, Inne H M; Vriens, Menno R; Valk, Gerlof D.

    2015-01-01

    CONTEXT: An association between ABO blood type and the development of cancer, in particular, pancreatic cancer, has been reported in the literature. An association between blood type O and neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) patients was recently suggested. Therefore,

  3. No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

    NARCIS (Netherlands)

    Nell, Sjoerd; Van Leeuwaarde, Rachel S.; Pieterman, Carolina R. C.; de Laat, Joanne M.; Hermus, Ad R.; Dekkers, Olaf M.; de Herder, Wouter W.; van der Horst-Schrivers, Anouk N.; Drent, Madeleine L.; Bisschop, Peter H.; Havekes, Bas; Rinkes, Inne H. M. Borel; Vriens, Menno R.; Valk, Gerlof D.

    2015-01-01

    Context: An association between ABO blood type and the development of cancer, in particular, pancreatic cancer, has been reported in the literature. An association between blood type O and neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) patients was recently suggested. Therefore,

  4. Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with Cryptorchidism

    DEFF Research Database (Denmark)

    Kvist, Kolja; Clasen-Linde, Erik; Cortes, Dina;

    2014-01-01

    Intratubular germ cell neoplasia is a precursor to testicular germ cell cancer. The condition is characterized by large germ cells with large nuclei with a hyperchromatic, coarse chromatin pattern, large prominent nucleoli and abundant pale cytoplasm. In prepubertal boys these cells are located c...

  5. Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3

    NARCIS (Netherlands)

    Boers, A; Wang, R; van Leeuwen, R W; Klip, H G; de Bock, G H; Hollema, H; van Criekinge, W; de Meyer, T; Denil, S; van der Zee, A G J; Schuuring, E; Wisman, G B A

    2016-01-01

    BACKGROUND: Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both high sensitivity as well as high specificity remains a challenge. In this study, w

  6. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia

    NARCIS (Netherlands)

    Visser, J.; Nijman, H. W.; Hoogenboom, B.-N.; Jager, P.; van Baarle, D.; Schuuring, E.; Abdulahad, W.; Miedema, F.; van der Zee, A. G.; Daemen, T.

    2007-01-01

    Oncogenic human papillomavirus (HPV)-infection is crucial for developing cervical cancer and its precursor lesions [cervical intraepithelial neoplasia (CIN)]. Regulatory T cells (T-regs) might be involved in the failure of the immune system to control the development of HPV-induced cancer. We invest

  7. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

    NARCIS (Netherlands)

    Srigley, J.R.; Delahunt, B.; Eble, J.N.; Egevad, L.; Epstein, J.I.; Grignon, D.; Hes, O.; Moch, H.; Montironi, R.; Tickoo, S.K.; Zhou, M.; Argani, P.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group p

  8. Condom use in prevention of Human Papillomavirus infections and cervical neoplasia: systematic review of longitudinal studies.

    Science.gov (United States)

    Lam, Janni Uyen Hoa; Rebolj, Matejka; Dugué, Pierre-Antoine; Bonde, Jesper; von Euler-Chelpin, My; Lynge, Elsebeth

    2014-03-01

    Based on cross-sectional studies, the data on protection from Human Papillomavirus (HPV) infections related to using male condoms appear inconsistent. Longitudinal studies are more informative for this purpose. We undertook a systematic review of longitudinal studies on the effectiveness of male condoms in preventing HPV infection and cervical neoplasia. We searched PubMed using MeSH terms for articles published until May 2013. Articles were included if they studied a change in non-immunocompromized women's cervical HPV infection or cervical lesion status along with the frequency of condom use. In total, 384 abstracts were retrieved. Eight studies reported in 10 articles met the inclusion criteria for the final review. Four studies showed a statistically significantly protective effect of consistent condom use on HPV infection and on regression of cervical neoplasia. In the remaining four studies, a protective effect was also observed for these outcomes, although it was not statistically significant. Consistent condom use appears to offer a relatively good protection from HPV infections and associated cervical neoplasia. Advice to use condoms might be used as an additional instrument to prevent unnecessary colposcopies and neoplasia treatments in cervical screening, and to reduce the risk of cervical cancer.

  9. The management of cervical intra-epithelial neoplasia (CIN): Extensiveness and costs in The Netherlands

    NARCIS (Netherlands)

    M. van Ballegooijen (Marjolein); M.A. Koopmanschap (Marc); J.D.F. Habbema (Dik)

    1995-01-01

    textabstractIn order to provide greater insight into both the extensiveness and the medical costs of the diagnosis and treatment of screen-detected cervical intra-epithelial neoplasia (CIN) in general medical practice in The Netherlands, data from national registries and gynaecology departments were

  10. Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review

    Directory of Open Access Journals (Sweden)

    Fábio Russomano

    2000-07-01

    Full Text Available CONTEXT: The treatment of the subclinical Human papillomavirus (HPV infection of the uterine cervix is controversial. OBJECTIVE: To assess the efficacy of any therapy for subclinical HPV infection of the cervix without intraepithelial neoplasia, via a search in the medical literature. METHOD: We performed a systematic review with a comprehensive reference search in Medline, LILACS, Excerpta Medica, AIDSLINE, Popline, Cochrane Library and other authors' reference lists to identify experimental studies of therapy for subclinical HPV infection without intraepithelial neoplasia of the uterine cervix. In order to identify unpublished studies, we also contacted experts in the area, clinical trial registries, pharmaceutical industries, government and research institutions. We also searched on the Internet and in the book-of-abstracts of some medical conferences. The studies identified were masked and selected by inclusion criteria to help ascertain their internal validity. The data about regression or progression of HPV infection were extracted from the studies included. RESULTS: We identified 67 studies related to the treatment of subclinical HPV infection without intraepithelial neoplasia of the uterine cervix. Only five clinical trials matched the inclusion criteria and none demonstrated significant differences between the experimental group and the control group concerning regression of HPV infection (with or without CIN I or progression to higher grades of CIN. CONCLUSION: The evidence we found in the medical literature regarding the efficacy of any therapy for subclinical HPV infection without intraepithelial neoplasia of the uterine cervix was unsatisfactory.

  11. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia

    NARCIS (Netherlands)

    Visser, J.; Nijman, H. W.; Hoogenboom, B.-N.; Jager, P.; van Baarle, D.; Schuuring, E.; Abdulahad, W.; Miedema, F.; van der Zee, A. G.; Daemen, T.

    2007-01-01

    Oncogenic human papillomavirus (HPV)-infection is crucial for developing cervical cancer and its precursor lesions [cervical intraepithelial neoplasia (CIN)]. Regulatory T cells (T-regs) might be involved in the failure of the immune system to control the development of HPV-induced cancer. We invest

  12. Natural history of high-grade cervical intraepithelial neoplasia : a review of prognostic biomarkers

    NARCIS (Netherlands)

    Koeneman, Margot M.; Kruitwagen, Roy F. P. M.; Nijman, Hans W.; Slangen, Brigitte F. M.; Van Gorp, Toon; Kruse, Arnold-Jan

    2015-01-01

    The natural history of high-grade cervical intraepithelial neoplasia (CIN) is largely unpredictable and current histopathological examination is unable to differentiate between lesions that will regress and those that will not. Therefore, most high-grade lesions are currently treated by surgical exc

  13. Sarcoma de estroma prostático gigante

    Directory of Open Access Journals (Sweden)

    Jose Luis González González

    Full Text Available Los tumores de próstata representan la neoplasia maligna más frecuente en el varón. Mientras que las lesiones epiteliales son frecuentes, las neoplasias de origen mesenquimal representan entre 1 y 2 % de las neoplasias malignas prostáticas. Son poco conocidas, sobre todo las de origen estromal. Se presenta el caso de un varón de 77 años de edad, con un sarcoma del estroma prostático al que se le realiza una exéresis parcial. El tumor ocupa prácticamente la totalidad de la cavidad pélvico-abdominal, con un diámetro de 35 cm y un peso de 3 800 g. Histológicamente se concluyó, como sarcoma prostático aunque en el transoperatorio no se encontró un nexo evidente con este órgano. El comportamiento clínico de estos tumores, basado en los escasos casos descritos en la literatura, es prácticamente desconocido y su diagnóstico preoperatorio difícil. Este paciente se presentó con pérdida de peso, sin dolor, hematuria, ni síntomas obstructivos.

  14. Endometriose Simulando Neoplasia Vesical Endometriosis Simulating Bladder Cancer

    Directory of Open Access Journals (Sweden)

    Marcos Tobias-Machado

    2000-04-01

    Full Text Available Objetivo: o acometimento do trato urinário pela endometriose é raro e quando ocorre, a bexiga é o órgão mais freqüentemente afetado. Observamos que algumas pacientes têm sido encaminhadas com o diagnóstico clínico de neoplasia vesical. Em geral, a literatura mostra relatos isolados de casos, tornando difícil a padronização de condutas. Tivemos por objetivo apresentar nossa experiência, mostrando os principais aspectos diagnósticos e terapêuticos desta entidade clínica. Métodos: avaliamos retrospectivamente os casos com diagnóstico de endometriose vesical por meio do arquivo do Departamento de Patologia, fazendo revisão dos dados clínicos de prontuário e convocando as pacientes para seguimento ambulatorial após tratamento. Resultados: os principais sinais e sintomas apresentados pelas pacientes foram disúria cíclica, massa e dor pélvica crônica. O diagnóstico presuntivo foi realizado mediante ultra-sonografia (USG, tomografia computadorizada (TC de abdome, cistoscopia e laparoscopia. O diagnóstico definitivo com confirmação anátomo-patológica foi obtido pela ressecção endoscópica em 3 casos e biópsia laparoscópica em 1 caso. As opções terapêuticas foram o tratamento medicamentoso exclusivo e a ressecção da lesão empregando a via endoscópica ou cistectomia parcial, sempre complementados por tratamento clínico adjuvante. Conclusões: revisamos os principais aspectos clínicos e terapêuticos da endometriose do trato urinário, lembrando que esta representa um importante diagnóstico diferencial de tumor vesical em mulheres jovens na idade reprodutiva.Purpose: urinary tract involvement by endometriosis is uncommon and the bladder is the most common site. We observed that clinical misdiagnosis of bladder cancer frequently is made. Because the disease is generally described in case reports there is not a consensual management. We present and discuss our experience of diagnostic and therapeutic issues

  15. Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia

    Directory of Open Access Journals (Sweden)

    Poulsen Steen S

    2010-01-01

    Full Text Available Abstract Background The pathogenesis for colorectal cancer remains unresolved. A growing body of evidence suggests a direct correlation between cyclooxygenase enzyme expression, prostaglandin E2 metabolism and neoplastic development. Thus further understanding of the regulation of epithelial functions by prostaglandin E2 is needed. We hypothesized that patients with colonic neoplasia have altered colonic epithelial ion transport and express functionally different prostanoid receptor levels in this respect. Methods Patients referred for colonoscopy were included and grouped into patients with and without colorectal neoplasia. Patients without endoscopic findings of neoplasia served as controls. Biopsy specimens were obtained from normally appearing mucosa in the sigmoid part of colon. Biopsies were mounted in miniaturized modified Ussing air-suction chambers. Indomethacin (10 μM, various stimulators and inhibitors of prostanoid receptors and ion transport were subsequently added to the chamber solutions. Electrogenic ion transport parameters (short circuit current and slope conductance were recorded. Tissue pathology and tissue damage before and after experiments was assessed by histology. Results Baseline short circuit current and slope conductance did not differ between the two groups. Patients with neoplasia were significantly more sensitive to indomethacin with a decrease in short circuit current of 15.1 ± 2.6 μA·cm-2 compared to controls, who showed a decrease of 10.5 ± 2.1 μA·cm-2 (p = 0.027. Stimulation or inhibition with theophylline, ouabain, bumetanide, forskolin or the EP receptor agonists prostaglandin E2, butaprost, sulprostone and prostaglandin E1 (OH did not differ significantly between the two groups. Histology was with normal findings in both groups. Conclusions Epithelial electrogenic transport is more sensitive to indomethacin in normal colonic mucosa from patients with previous or present colorectal neoplasia compared

  16. Expression of mutant protein p53 and Hsp70 and Hsp90 chaperones in cockles Cerastoderma edule affected by neoplasia.

    Science.gov (United States)

    Díaz, S; Cao, A; Villalba, A; Carballal, M J

    2010-07-01

    High prevalence of disseminated neoplasia has been found in cockles Cerastoderma edule of Galicia (NW Spain). Disseminated neoplasia has been associated with high mortalities of various bivalve species. In vertebrates, proteins such as p53 and heat shock proteins (HSPs) play important roles in carcinogenesis. The protein p53 has been detected in neoplastic cells of bivalve molluscs such as Mytilus edulis, Mytilus trossulus, Mya arenaria, Spisula solidissima, Crassostrea rhizophorae and Crassostrea gigas. In this study, western blotting analyses were used to test the expression of Hsp70, Hsp90 and mutant p53 proteins in the cells and plasma of the haemolymph of cockles showing various intensities of neoplasia. Disseminated neoplasia was previously diagnosed by examination of stained haemolymph monolayers with light microscopy. In the present study, mutant p53 was detected in haemolymph cells of cockles diagnosed as affected by moderate and heavy neoplasia intensity, whereas it was not detected in cockles with either no or light neoplasia. The higher the neoplasia intensity, the higher the levels of Hsp70 and Hsp90. These proteins were not found in plasma. The results reveal the possible association between p53 and HSPs in neoplastic cells of cockles, which could prevent p53 from carrying out its functions, as occurs in human cancers.

  17. Prospective evaluation of fecal calprotectin as a screening biomarker for colorectal neoplasia.

    Science.gov (United States)

    Limburg, Paul J; Devens, Mary E; Harrington, Jonathan J; Diehl, Nancy N; Mahoney, Douglas W; Ahlquist, David A

    2003-10-01

    Stool testing is a well established method of screening for colorectal neoplasia. Emerging data suggest that novel biomarkers may offer performance advantages over fecal occult blood. In this large, prospective study, we assessed fecal calprotectin (a leukocyte-derived protein) as a screening biomarker for colorectal neoplasia. Fecal calprotectin was directly compared to fecal hemoglobin (Hb) and colonoscopy as the existing criterion standards for stool screening and structural evaluation, respectively. Subjects included colonoscopy patients with a personal history of colorectal neoplasia, family history of colorectal cancer, or iron deficiency anemia. Stool specimens were collected before purgation, processed appropriately, and quantitatively analyzed for calprotectin (Nycomed Pharma, Oslo, Norway) and for Hb (Mayo Medical Laboratories, Rochester, MN) by masked technicians. Colonoscopies were performed by experienced endoscopists without prior knowledge of the fecal assay results. Among 412 subjects, 97 (24%) subjects had one or more colorectal neoplasms (including three with adenocarcinomas). Fecal calprotectin levels did not differ significantly between subjects with versus subjects without colorectal neoplasms (p = 0.33). Neither tumor number (p = 0.85) nor tumor size (p = 0.86) significantly influenced the observed fecal calprotectin concentrations. Estimates of the sensitivity, specificity, and positive and negative predictive values of fecal calprotectin for any colorectal neoplasms were 37%, 63%, 23%, and 76%, respectively. Comparable performance estimates for fecal Hb were 3%, 97%, 27%, and 77%, respectively. In this cohort of colonoscopy patients at above average risk, fecal calprotectin was a poor screening biomarker for colorectal neoplasia. Further investigation of tumor-derived, rather than blood-based, biomarkers may be a more rewarding approach to stool screening for colorectal neoplasia.

  18. Incidence and risk factors for colorectal neoplasia in patients with oral squamous cell carcinoma.

    Science.gov (United States)

    Kishikawa, H; Sato, K; Yamauchi, T; Katakura, A; Shibahara, T; Takano, N; Nishida, J

    2014-11-01

    Colorectal adenoma and cancer are not regarded as being associated with primary oral cancer. The aim of this study was to determine whether screening colonoscopy should be performed for patients with oral cancer in addition to the upper gastrointestinal endoscopic screening that is now routinely performed. Between 2007 and 2013, 162 patients with oral squamous cell carcinoma were enrolled at Tokyo Dental College, Ichikawa General Hospital, and 136 individuals were assigned to colonoscopic surveillance. Advanced neoplasia was defined as an adenoma ≥ 10 mm, adenoma with villous histology or high-grade dysplasia regardless of size and invasive cancer. Associations between advanced neoplasia and clinical factors, including age, sex, body mass index, physical activity, smoking, alcohol consumption and oral cancer site and staging were determined. Advanced neoplasia, including five invasive cancers, was identified in 32 (23.5%) patients. An age- and sex-adjusted multivariate analysis revealed that smoking (Brinkmann index > 400; OR = 3.24, 95% CI = 1.28-8.18), alcohol consumption (lifetime pure ethanol consumption > 600 l; OR = 2.84, 95% CI = 1.18-6.79) and a diagnosis of cancer of the floor of the mouth (OR = 7.97, 95% CI = 2.49-25.46) were independent risk factors for advanced colorectal neoplasia. The prevalence of advanced colorectal neoplasia is unexpectedly high in patients with oral cancer. It should be recognized as a second primary tumour of oral cancer. Screening of oral cancer patients by colonoscopy should be routine practice, particularly among smokers and patients with a high intake of alcohol and cancer of the floor of the mouth. Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland.

  19. Neumotórax bilateral como complicación de metástasis pulmonar cavitaria de un angiosarcoma

    Directory of Open Access Journals (Sweden)

    Lorena V. Maldonado

    2014-06-01

    Full Text Available Las metástasis pulmonares de angiosarcoma constituyen una complicación común de una neoplasia maligna poco frecuente. Habitualmente se presentan como nódulos solidos periféricos y derrame pleural. Presentamos el caso de un hombre de 65 años de edad con neumotórax bilateral recurrente, secundario a metástasis cavitadas de un angiosarcoma primitivo de cuero cabelludo. La videotoracoscopia permitió la inspección, la resección de las metástasis y la pleurodesis. No ocurrieron complicaciones ni recurrencia tumoral a los seis meses de seguimiento.

  20. Neumotórax bilateral como complicación de metástasis pulmonar cavitaria de un angiosarcoma

    OpenAIRE

    Lorena V. Maldonado; Silvia Quadrelli; Gustavo Lyons; Juan C. Spina; Julio Venditti; Felipe J. Chertcoff

    2014-01-01

    Las metástasis pulmonares de angiosarcoma constituyen una complicación común de una neoplasia maligna poco frecuente. Habitualmente se presentan como nódulos solidos periféricos y derrame pleural. Presentamos el caso de un hombre de 65 años de edad con neumotórax bilateral recurrente, secundario a metástasis cavitadas de un angiosarcoma primitivo de cuero cabelludo. La videotoracoscopia permitió la inspección, la resección de las metástasis y la pleurodesis. No ocurrieron complicaciones ni re...

  1. Cáncer cutáneo por exposición ocupacional a agentes químicos

    OpenAIRE

    Santiago José Rocha Eiroa; María Teresa Ferreiro Losada; María Izaskum Regal Faraldo

    2014-01-01

    El cáncer cutáneo profesional integra un grupo de neoplasias malignas atribuibles a la exposición a factores cancerígenos en el medio laboral. Presenta dificultades en el diagnóstico debido a su etiología multifactorial, existencia de diferentes desencadenantes durante la vida laboral y no laboral, largos periodos de latencia y una clínica semejante a las no profesionales. Actualmente existen diferencias entre las sustancias químicas identificadas en el listado de enfermedades profesionales c...

  2. La técnica de exploración con Imagen de Banda Estrecha o Narrow Band Imaging (NBI) en carcinomas epidermoides de la vía aerodigestiva superior

    OpenAIRE

    Barberá Durbán, Rafael

    2014-01-01

    INTRODUCCIÓN: La mayoría de las neoplasias malignas de cabeza y cuello son carcinomas epidermoides originados en la vía aerodigestiva superior. Debido a su localización preferente en la superficie de la mucosa, la exploración endoscópica en la consulta es fundamental. Para mejorar la exploración visual endoscópica de las lesiones y tratar de aislarlas de la mucosa sana se ha desarrollado la técnica de exploración con luz de banda estrecha (Narrow Band Imaging o NBI). Inicialmente utilizada pa...

  3. Presentacion clínica inusual de metástasis cutánea de carcinoma mamario: A propósito de un caso Inusual Clinical Presentation Of Cutaneous Metastasis From Breast Carcinoma: A Case Report

    OpenAIRE

    2009-01-01

    Las Metástasis Cutáneas (MC) son entidades clínicas destacadas pues representan entre el 1% al 5 % de las lesiones cutáneas observadas en Dermatología, adquieren mayor importancia ya que pueden ser el primer o único signo clínico de un tumor oculto. Pueden ser únicas o múltiples, asintomáticas y de aspecto clínico variado. Eventualmente cualquier neoplasia maligna puede metastatizar en la piel, pero en la mujer el origen mamario es el más frecuente y en el hombre ese lugar está ocupado por lo...

  4. Las bases celulares de las oscilaciones neuronales

    OpenAIRE

    Mario Treviño; Rafael Gutiérrez

    2007-01-01

    Una de las características de los circuitos neuronales es que sus componentes, las neuronas, pueden presentar actividad eléctrica sincrónica y, gracias a ésta, generar actividad oscilatoria. Esta actividad se ha asociado a diversas funciones fisiológicas como el procesamiento de información sensorial, la memoria, el ciclo vigiliasueño y la conciencia. La actividad oscilatoria de un circuito neuronal está mediada por i) las propiedades intrínsecas de sus células, ii) la arquitectura de sus con...

  5. Primary Hyperparathyroidism in Young People. When Should We Perform Genetic Testing for Multiple Endocrine Neoplasia 1 (MEN-1)?

    DEFF Research Database (Denmark)

    Lassen, Tina Harmer; Friis-Hansen, Lennart Jan; Rasmussen, Åse Krogh

    2014-01-01

    CONTEXT: Multiple endocrine neoplasia (MEN-1) is a rare, autosomal dominant inherited disorder. Primary hyperparathyroidism (pHPT) is the most frequent and usually the earliest expression of MEN-1, with typical age of onset at 20-25 years. Early detection of the disease and correct treatment...... endocrine neoplasia 1 OR multiple endocrine neoplasia type 1 AND Mutational analysis OR genetic testing OR testing OR Hyperparathyroidism, primary [majr]. A total of 625 abstracts were reviewed. RESULTS AND DISCUSSION: Whether to perform screening of patients with pHPT under the age of 30, 35, or 40 years...

  6. Screening by Total Colonoscopy Following Fecal Immunochemical Tests and Determinants of Colorectal Neoplasia in Japanese Men With Alcohol Dependence.

    Science.gov (United States)

    Mizukami, Takeshi; Yokoyama, Akira; Yokoyama, Tetsuji; Onuki, Shuka; Maruyama, Katsuya

    2017-03-09

    Alcohol consumption increases the risk of colorectal adenoma and cancer. The fecal immunochemical test (FIT) is a widely used screening method for detecting colorectal neoplasia. We evaluated the results of screening and risk factors for colorectal neoplasia in individuals with alcohol dependence. Total colonoscopic screening was performed for 1006 Japanese men with alcohol dependence (462 FIT-positive and 544 FIT-negative). Advanced neoplasia was defined as neoplasia ≥10 mm, villous or tubulovillous adenoma, high-grade adenoma, or carcinoma. The detection rates for non-advanced adenoma, advanced neoplasia and intramucosal or invasive carcinoma were 38.7%, 39.4% and 9.7% for the FIT-positive group, and 33.3%, 10.8% and 2.2% for the FIT-negative group, respectively. Advanced neoplasia, especially carcinoma, was detected more frequently in the distal colon than in the proximal colon in the FIT-positive group. The respective multivariate odds ratios (ORs; 95% confidence interval) for non-advanced adenoma and advanced neoplasia were 2.83 (2.06–3.88) and 9.13 (6.19–13.5) for a positive FIT (vs. negative), 1.68 (1.39–2.02) and 1.83 (1.45–2.30) for age (per +10 years), 1.54 (1.06–2.23) and 1.88 (1.17–3.03) for current smoking (vs. non-smokers), and 1.35 (0.96–1.92) and 1.59 (1.02–2.48) for the presence of marked macrocytosis (mean corpuscular volume ≥106 fl vs. alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 did not affect the risk of colorectal neoplasia. The detection rate for advanced colorectal neoplasia was extremely high in the FIT-positive group but remained high even in the FIT-negative group. An older age, smoking and macrocytosis were predictors of advanced colorectal neoplasia. Total colonoscopic screening was performed for 1006 Japanese alcoholic men (462 fecal immunochemical test [FIT]-positive and 544 FIT-negative). The detection rate for advanced colorectal neoplasia was extremely high in the FIT-positive group (39.4%) and high in

  7. Las versiones homericas Las versiones homericas

    Directory of Open Access Journals (Sweden)

    Jorge Luis Borges

    2008-04-01

    Full Text Available Ningún problema tan consustancial con las letras con su modesto misterio como el que propone una traducción. Un olvido animal por la vanidad, el tenor de confesar procesos mentales que adivinamos peligrosamente comunes, el conato de mantener intacta y central una reserve incalculable de sombre, velan las tales escrituras directas. La traducciOn, en cambio, parece destinada a ilustrar la discusión estitica. El modelo propuesto a su imitaciOn es un texto visible, no un labirint° inestimable de proyectos preteritos o la acatada tentaciOn momentanea de una facilidad. Bertrand Russell define un objeto extern( como un sistema circular, irradiante, de impresiones posibles; lo mismo puede aseverarse de un texto, dadas las repercusiones incalculables de lo verbal. Un parcial y precioso documento de las vicisitudes que sufre queda en sus traducciones.

  8. Las lenguas en las sociedades del conocimiento

    Directory of Open Access Journals (Sweden)

    Álvarez, J. Francisco

    2008-12-01

    Full Text Available Languages become a strategic resource for information and knowledge societies. By expressing and sharing knowledge by means of languages, every culture generates deposits of knowledge, which can be transferred and exchanged among different epistemic communities. The contemporary technologies of information and communication have changed the structure of knowledge flows. Globalization of knowledge poses a great challenge to every language, including the Spanish one. In order to survive in the digital world, they should develop technolanguages. The lemma “Thinking in Spanish” implies a new model of governance for the Ibero-American knowledge communities.En las sociedades de la información y el conocimiento las lenguas se convierten en un recurso estratégico. Al expresar y compartir conocimiento por medio de los idiomas, las culturas generan yacimientos de conocimiento, que pueden ser transferidos e intercambiados entre comunidades epistémicas diferentes. Las actuales tecnologías de la información y la comunicación han cambiado la estructura de los flujos de conocimiento. La globalización del conocimiento plantea un gran desafío a todas las lenguas, incluyendo la española. Para sobrevivir en el mundo digital, los lenguajes han de convertirse en tecnolenguajes. El lema “Pensar en español” aporta un nuevo modelo de gobernanza para las comunidades iberoamericanas del conocimiento.

  9. ¿Mordida de bruja o enfermedad? Las muertes de niños en un pueblo tlaxcalteca (México, 1917-1922

    Directory of Open Access Journals (Sweden)

    Marciano Netzahualcoyotzi Méndez

    2015-02-01

    Full Text Available Sustentado en sus creencias de arraigo prehispánico y colonial, los habitantes de San Bernardino Contla creían en las intenciones malignas de la bruja, en especial contra los niños recién nacidos. Inmersos en su propia cosmovisión, en esta investigación se explicará la razón por la cual la autoridad civil avalaba las muertes de niños por consecuencia de la mordida de bruja y, contrariamente, la postura del cura católico al argumentar la presencia de enfermedades propias de la infancia: la alferecía y la calentura. Gracias a que los padres refirieron el ataque nocturno de la bruja, el mito adquiere el sentido fantasioso, legendario y, a la vez, temeroso. Alternativamente, para prevenir el ataque de la bruja se realizaban rituales de protección. Con el propósito de sentirse confiados, al inicio de la noche los padres colocaban en la cama del niño un espejo y una tijera, y detrás de la puerta de la casa, un crucifico y una cubeta con agua. Referente a las huellas físicas de los difuntos se derivan dos posibilidades: una asociada con una enfermedad y la otra con la asfixia. Complementariamente, se conocerá la legislación tlaxcalteca que posibilitaba el registro de defunciones relacionadas con las causas míticas.

  10. ¿Mordida de bruja o enfermedad? Las muertes de niños en un pueblo tlaxcalteca (México, 1917-1922

    Directory of Open Access Journals (Sweden)

    Marciano Netzahualcoyotzi Méndez

    2015-01-01

    Full Text Available Sustentado en sus creencias de arraigo prehispánico y colonial, los habitantes de San Bernardino Contla creían en las intenciones malignas de la bruja, en especial contra los niños recién nacidos. Inmersos en su propia cosmovisión, en esta investigación se explicará la razón por la cual la autoridad civil avalaba las muertes de niños por consecuencia de la mordida de bruja y, contrariamente, la postura del cura católico al argumentar la presencia de enfermedades propias de la infancia: la alferecía y la calentura. Gracias a que los padres refirieron el ataque nocturno de la bruja, el mito adquiere el sentido fantasioso, legendario y, a la vez, temeroso. Alternativamente, para prevenir el ataque de la bruja se realizaban rituales de protección. Con el propósito de sentirse confiados, al inicio de la noche los padres colocaban en la cama del niño un espejo y una tijera, y detrás de la puerta de la casa, un crucifico y una cubeta con agua. Referente a las huellas físicas de los difuntos se derivan dos posibilidades: una asociada con una enfermedad y la otra con la asfixia. Complementariamente, se conocerá la legislación tlaxcalteca que posibilitaba el registro de defunciones relacionadas con las causas míticas.

  11. Untypable human papillomavirus infection and risk of cervical intraepithelial neoplasia among women with abnormal cervical cytology.

    Science.gov (United States)

    Spinillo, Arsenio; Gardella, Barbara; Roccio, Marianna; Alberizzi, Paola; Silini, Enrico Maria; Dal Bello, Barbara

    2014-07-01

    The risk of cervical intraepithelial neoplasia and/or invasive cervical cancer associated with untypable human papillomavirus (HPV) infections has been not investigated fully. HPV infection caused by 18 high-risk and 7 low-risk genotypes as detected by the INNO-LIPA genotyping system, was investigated in 4,258 women with abnormal Pap smear referred to a colposcopic service. The prevalence of HPV infection was 76.1%. Rates of cervical intraepithelial neoplasia grade 3+ were 0.88% (9/1,017) in HPV-negative subjects, 1.8% (7/380) in subjects with untypable HPV infection, 3.2% (11/343) in subjects with single/multiple low-risk types, 28.3% (201/709) in subjects with multiple low and high-risk types, 15.2% (162/1,069) in subjects with single high-risk types, and 31.2% (229/733) in those with multiple high-risk types. Compared to women without any HPV infection, the odds ratios of cervical intraepithelial neoplasia grade 2+ or grade 3+ in subjects with untypable or low-risk HPV genotypes were 5.73 (95% CI = 2.79-11.78) and 12.4 (95% CI = 6.31-24.5, P = 0.014 compared to untypable) and 3.1 (95% CI = 1.11-8.16) and 7.1 (95% CI = 2.9-17.2, P = 0.07 compared to untypable), respectively. In the subgroup of subjects with cervical intraepithelial neoplasia grade 1 or negative colposcopy/biopsy, the progression to cervical intraepithelial neoplasia grade 2+ at follow-up (median 25 months, range 6-70) was 2% (14/684), 3.4% (7/205), and 5.6% (11/195, P = 0.04 compared to negative) among negative, untypable, and low-risk HPV infection, respectively. The risk of cervical intraepithelial neoplasia associated with untypable HPV infection was higher than that recorded among uninfected women, but lower than the risk associated with low- or high-risk HPV genotypes. © 2014 Wiley Periodicals, Inc.

  12. La dicotomía de los virus polioma: ¿Infección lítica o inducción de neoplasias? The paradox of polyomaviruses Lytic infection or tumor induction?

    Directory of Open Access Journals (Sweden)

    Norberto A. Sanjuan

    2004-02-01

    Full Text Available Los virus Polioma murinos provocan infecciones líticas en cultivos de células de ratón y transforman in vitro células de rata a través de la interacción de su oncogén mT con diversos reguladores celulares. Luego de su inoculación en ratones neonatos inducen neoplasias epiteliales y mesenquimáticas. Se ha propuesto que las cepas de polioma más oncogénicas son aquellas que previamente replican más en el ratón. Sin embargo, a nivel de una sola célula la infección lítica y la transformación deberían ser mutuamente excluyentes. En cada neoplasia han sido descriptos 3 tipos celulares según expresen el DNA viral solo o concomitantemente con la proteína mayor de la cápside VP1, o que no contengan DNA viral ni VP-1. En nuestro laboratorio detectamos la existencia de un cuarto tipo celular en las neoplasias, en el que se expresa la totalidad del genoma viral pero no ocurre el ensamblaje, probablemente por alteraciones en la fosforilación de VP-1. Se discuten los mecanismos de migración intracelular de Polioma, la diseminación en el ratón y los factores que podrían estar involucrados en la inducción de neoplasias o en la infección lítica inducidas por el virus.Murine polyomaviruses can produce lytic infections in mouse cell cultures or transform in vitro rat fibroblasts through a complex interaction with key cellular regulators. After infection of newborn mice, some strains of polyomavirus induce epithelial and mesenchymal tumors. It has been described that there is a direct relationship between viral dissemination in the mouse and tumor induction. However, at a single cell level lytic infection and transformation would not be able to coexist. The existence of 3 distinct cell populations in polyoma-induced tumors, classified according to the presence or absence of viral DNA and viral capsid protein VP-1 have been described. We have reported a fourth type of cell in the neoplasms, that can express the early and the late viral

  13. Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia

    National Research Council Canada - National Science Library

    Kim, Tae Eun; Kim, Hwal Woong; Lee, Kyung Eun

    2014-01-01

    This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia with HPV 52 and 58 infections...

  14. Lesões pré-malignas

    OpenAIRE

    Teixeira, Lívio António Neves

    2015-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária O cancro oral é a forma de cancro mais comum da cabeça e pescoço, e nos últimos anos, tem-se observado ao aumento da sua incidência, bem como, aumento da sua mortalidade. Numa fase inicial do carcinoma espinocelular oral, a forma mais prevalente de cancro oral, as manifestações clínicas e os sintomas são mínimos, sendo por isso im...

  15. Treinamento e critérios padronizados aprimoram o diagnóstico de lesões pré-malignas da mama Training and standardized criteria improve the diagnosis of premalignant breast lesions

    Directory of Open Access Journals (Sweden)

    Marcio de Almeida Salles

    2008-11-01

    Full Text Available OBJETIVO: analisar a variabilidade interobservador no diagnóstico histopatológico de lesões mamárias consideradas pré-malignas antes e após o treinamento com o uso de critérios diagnósticos padronizados. MÉTODOS: foram utilizadas lâminas contendo cortes histológicos representativos de três tipos de lesões mamárias (hiperplasia ductal atípica, carcinoma ductal in situ e carcinoma ductal in situ com microinvasão revistas por um especialista internacional em patologia mamária e cujos diagnósticos foram considerados como padrão de referência. As mesmas lâminas foram avaliadas em dois tempos por cinco patologistas da comunidade que receberam um protocolo específico para classificar as lesões. Na primeira avaliação, os casos foram analisados e classificados usando critérios específicos adotados em cada serviço. Num segundo tempo, os patologistas receberam um tutorial contendo critérios diagnósticos e imagens representativas e novamente classificaram as lesões empregando os critérios padronizados. Foi realizada análise interobservador usando concordância percentual e o índice de Kappa ponderado. RESULTADOS: houve grande variabilidade diagnóstica entre os patologistas na análise inicial sem o uso de critérios diagnósticos padronizados quanto ao diagnóstico, grau nuclear e grau histológico (os índices de Kappa ponderado quanto ao diagnóstico variaram de 0,15 a 0,40. Na segunda avaliação, utilizando-se critérios padronizados, houve significativa melhora na concordância diagnóstica entre os cinco patologistas quanto ao diagnóstico, grau nuclear e grau histológico (os índices de Kappa ponderado quanto ao diagnóstico variaram de 0,42 a 0,80. CONCLUSÕES: a concordância interobservador no diagnóstico e classificação das lesões pré-malignas da mama pode ser melhorada com o treinamento específico e o uso de critérios histopatológicos padronizados.PURPOSE: to analyze interobserver variability in the

  16. Tratamiento con electrocauterización de las lesiones premalignas del cérvix

    Directory of Open Access Journals (Sweden)

    Israel Meza G

    2014-11-01

    Full Text Available Se presentaron los resultados del tratamiento con electrocauterización de las neoplasias intraepiteliales del cérvix en 430 pacientes atendidas en el Hospital Universitario del Valle, en el Hospital San Juan de Dios y en el Centro Hospital Cañaveralejo en Cali, Colombia, entre 1982 y 1992. Inicialmente se seleccionaron 455 mujeres que consultaron con citologías anormales (inclusive Papanicolau II con cambios coilocíticos y atipias inflamatorias. Para el análisis final sólo se incluyeron 430 pacientes. A todas se les practicó colposcopia y biopsia dirigida y se confirmaba el diagnóstico de neoplasia intraepitelial del cérvix. Se hizo seguimiento con citología y colposcopia. Se obtuvo una respuesta global de 90.1% al primer tratamiento, respuesta que aumenta a 96.8% cuando se incluyeron las pacientes que respondieron a un segundo tratamiento. Se discuten las ventajas y desventajas del método con respeto a otros métodos existentes.

  17. Examination for intratubular germ cell neoplasia at operation for undescended testis in boys

    DEFF Research Database (Denmark)

    Cortes, Dina; Thorup, Jørgen Mogens; Frisch, M;

    1994-01-01

    A total of 843 consecutive boys (median age 12.7 years) who had undergone testicular biopsy at operation for undescended testis was followed into adulthood (median age 25.2 years) to examine for testicular germ cell neoplasia. Five cases of testicular germ cell neoplasia were identified, including...... testicular biopsy from the patient in whom nonseminoma was noted at followup showed Sertoli cells only. We recommend that testicular biopsy be performed at operation for undescended testis in boys with abnormal sex chromosomes, particularly 45,X/46,XY karyotype, and in those with abnormal external genitalia....... The pattern of Sertoli cells only in biopsies from boys does not preclude the occurrence of testicular cancer in adulthood....

  18. Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia

    DEFF Research Database (Denmark)

    Hvarness, Tine; Nielsen, John E; Almstrup, Kristian

    2013-01-01

    and overt seminoma, in comparison to biopsies from infertile men without neoplasia. The composition of immune cells was similar across all the groups studied. Macrophages, CD8(+) and CD45R0(+) T lymphocytes constituted the majority of infiltrates, B lymphocytes were present in an intermediate proportion......Immune cells often infiltrate testicular germ cell neoplasms, including pre-invasive carcinoma in situ (CIS), but the significance of this phenomenon remains unknown. The composition and distribution of infiltrating immune cells were examined by immunohistochemistry in testis samples with CIS...... and very few CD4(+) and FoxP3(+) T cells were detected. HLA-I antigen was more abundant in Sertoli cells in tubules containing CIS than in those with normal spermatogenesis. This study showed a phenotypically comparable composition of infiltrating immune cells independently of the presence of neoplasia...

  19. Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles.

    Science.gov (United States)

    Khondee, Supang; Rabinsky, Emily F; Owens, Scott R; Joshi, Bishnu P; Qiu, Zhen; Duan, Xiyu; Zhao, Lili; Wang, Thomas D

    2015-02-10

    Many powerful drugs have limited clinical utility because of poor water solubility and high systemic toxicity. Here, we formulated a targeted nanomedicine, rapamycin encapsulated in pegylated octadecyl lithocholate micelles labeled with a new ligand for colorectal neoplasia, LTTHYKL peptide. CPC;Apc mice that spontaneously develop colonic adenomas were treated with free rapamycin, plain rapamycin micelles, and peptide-labeled rapamycin micelles via intraperitoneal injection for 35days. Endoscopy was performed to monitor adenoma regression in vivo. We observed complete adenoma regression at the end of therapy. The mean regression rate for peptide-labeled rapamycin micelles was significantly greater than that for plain rapamycin micelles, Prapamycin micelles compared to that of free drug, and no other toxicities were found on chemistries. Together, this unique targeted micelle represents a potential therapeutic for colorectal neoplasia with comparable therapeutic efficacy to rapamycin free drug and significantly less systemic toxicity.

  20. Penile intraepithelial neoplasia with pagetoid features: report of an unusual variant mimicking Paget disease.

    Science.gov (United States)

    Amin, Ali; Griffith, Rogers C; Chaux, Alcides

    2014-04-01

    Precancerous lesions of the penis frequently share the morphologic features of the invasive counterpart. We have recently subclassified penile intraepithelial neoplasia into differentiated, warty, and basaloid subtypes, each one with distinctive microscopic morphology. Nevertheless, in our experience, some cases depart from this classification scheme and show unusual morphologic features, hindering the proper diagnosis on routine morphology alone. Herein we present a case of penile intraepithelial neoplasia with a pagetoid growth pattern, closely mimicking Paget disease. We describe the necessary steps to reach the final diagnose, including the use of immunohistochemistry for cytokeratin (CK) 7, CK20, CK34βE12, CAM 5.2, AE1/AE3, CEA, S100, Melan-A, and p63. We also discuss other differential diagnoses that should be considered such as malignant melanoma and urothelial carcinoma in situ with pagetoid spread and less common lesions such as pagetoid dyskeratosis, clear cell papulosis, and mucinous metaplasia.

  1. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia

    DEFF Research Database (Denmark)

    Gudjonsson, Thorarinn; Adriance, Melissa C; Sternlicht, Mark D;

    2005-01-01

    The human breast epithelium is a branching ductal system composed of an inner layer of polarized luminal epithelial cells and an outer layer of myoepithelial cells that terminate in distally located terminal duct lobular units (TDLUs). While the luminal epithelial cell has received the most...... the subject of investigation pertains to how the luminal epithelial and myoepithelial lineages are related and precisely how they arise from a common putative stem cell population within the breast. Equally important is the question of how heterotypic signaling occurs between luminal epithelial...... and surrounding myoepithelial cells in normal breast morphogenesis and neoplasia. In this review we discuss data from our laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia....

  2. Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia

    DEFF Research Database (Denmark)

    Kaltoft, Nicolai; Tilotta, Maria C; Witte, Anne-Barbara;

    2010-01-01

    BACKGROUND: The pathogenesis for colorectal cancer remains unresolved. A growing body of evidence suggests a direct correlation between cyclooxygenase enzyme expression, prostaglandin E2 metabolism and neoplastic development. Thus further understanding of the regulation of epithelial functions...... colorectal neoplasia. Patients without endoscopic findings of neoplasia served as controls. Biopsy specimens were obtained from normally appearing mucosa in the sigmoid part of colon. Biopsies were mounted in miniaturized modified Ussing air-suction chambers. Indomethacin (10 microM), various stimulators...... and inhibitors of prostanoid receptors and ion transport were subsequently added to the chamber solutions. Electrogenic ion transport parameters (short circuit current and slope conductance) were recorded. Tissue pathology and tissue damage before and after experiments was assessed by histology. RESULTS...

  3. Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development

    DEFF Research Database (Denmark)

    Jørgensen, Anne; Lindhardt Johansen, Marie; Juul, Anders

    2015-01-01

    Development of human gonads is a sex-dimorphic process which evolved to produce sex-specific types of germ cells. The process of gonadal sex differentiation is directed by the action of the somatic cells and ultimately results in germ cells differentiating to become functional gametes through...... spermatogenesis or oogenesis. This tightly controlled process depends on the proper sequential expression of many genes and signalling pathways. Disturbances of this process can be manifested as a large spectrum of disorders, ranging from severe disorders of sex development (DSD) to - in the genetic male - mild...... reproductive problems within the testicular dysgenesis syndrome (TDS), with large overlap between the syndromes. These disorders carry an increased but variable risk of germ cell neoplasia. In this review, we discuss the pathogenesis of germ cell neoplasia associated with gonadal dysgenesis, especially...

  4. No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia

    DEFF Research Database (Denmark)

    Raitila, A; Georgitsi, M; Karhu, A;

    2007-01-01

    Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene were recently observed in patients with pituitary adenoma predisposition (PAP). Though AIP mutation-positive individuals with prolactin-, mixed growth hormone/prolactin-, and ACTH-producing pituitary adenomas as well...... as non-secreting pituitary adenomas have been reported, most mutation-positive patients have had growth hormone-producing adenomas diagnosed at relatively young age. Pituitary adenomas are also component tumors of some familial endocrine neoplasia syndromes such as multiple endocrine neoplasia type 1....... Here, we have analyzed 32 pituitary adenomas and 79 other tumors of the endocrine system for somatic AIP mutations by direct sequencing. No somatic mutations were identified. However, two out of nine patients with prolactin-producing adenoma were shown to harbor a Finnish founder mutation (Q14X...

  5. Immunomodulatory effects of alpha interferon and thymostimulin in patients with neoplasias.

    Science.gov (United States)

    Munno, I; Marinaro, M; Gesario, A; Cannuscio, B; Michel, Y; Paulling, E

    1995-01-01

    In this report, we have evaluated the immunological effects following administration of alpha interferon (IFN-alpha) in combination with thymostimulin (TP-1), as well as of IFN-alpha and TP-1 alone in patients with neoplasias who underwent surgery and were subsequently treated with conventional chemotherapy. Data suggest that the combination of IFN-alpha and TP-1 is the most effective in the up-regulation of some immune parameters such as the CD4(+)-CD8+ cell-dependent antibacterial activity. Since this immune function plays an important role in the host protection against different targets such as invading microorganisms and/or neoplastic cells, the administration of TP-1-IFN-alpha is advisable for patients with neoplasias under chemotherapy. PMID:7583935

  6. Postoperative Complications After Prophylactic Thyroidectomy for Very Young Patients With Multiple Endocrine Neoplasia Type 2

    OpenAIRE

    Kluijfhout, Wouter P; van Beek, Dirk-Jan; Verrijn Stuart, Annemarie A.; Lodewijk, Lutske; Gerlof D. Valk; Van der Zee, David C.; Vriens, Menno R.; Inne H. M. Borel Rinkes

    2015-01-01

    Abstract The aim of this study was to investigate whether younger age at surgery is associated with the increased incidence of postoperative complications after prophylactic thyroidectomy in pediatric patients with multiple endocrine neoplasia (MEN) 2. The shift toward earlier thyroidectomy has resulted in significantly less medullary thyroid carcinoma (MTC)-related morbidity and mortality. However, very young pediatric patients might have a higher morbidity rate compared with older patients....

  7. Association of Chlamydia trachomatis infection with human papillomavirus (HPV) & cervical intraepithelial neoplasia - A pilot study

    OpenAIRE

    Neerja Bhatla; Kriti Puri; Elizabeth Joseph; Alka Kriplani; Venkateswaran K. Iyer; Sreenivas, V

    2013-01-01

    Background & objectives: Human papillomavirus (HPV) is the necessary cause of cervical cancer and Chlamydia trachomatis (CT) is considered a potential cofactor in the development of cervical intraepithelial neoplasia (CIN). The objective of this pilot study was to determine the association of CT infection with HPV, other risk factors for cervical cancer, and CIN in symptomatic women. Methods: A total of 600 consecutively selected women aged 30-74 yr with persistent vaginal discharge, inter...

  8. First-line chemotherapy in low-risk gestational trophoblastic neoplasia.

    LENUS (Irish Health Repository)

    Alazzam, Mo'iad

    2012-01-01

    This is an update of a Cochrane review that was first published in Issue 1, 2009. Gestational trophoblastic neoplasia (GTN) is a rare but curable disease arising in the fetal chorion during pregnancy. Most women with low-risk GTN will be cured by evacuation of the uterus with or without single-agent chemotherapy. However, chemotherapy regimens vary between treatment centres worldwide and the comparable benefits and risks of these different regimens are unclear.

  9. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia

    OpenAIRE

    Oscar Peralta-Zaragoza; Jessica Deas; Claudia Gómez-Cerón; Wendy Argelia García-Suastegui; Geny del Socorro Fierros-Zárate; Nadia Judith Jacobo-Herrera

    2013-01-01

    Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer. HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia...

  10. Prognostic Significance of Immunohistochemical Phenotypes in Patients Treated for High-Grade Cervical Intraepithelial Neoplasia

    OpenAIRE

    Massimo Origoni; Marta Parma; Giacomo Dell'Antonio; Chiara Gelardi; Chiara Stefani; Stefano Salvatore; Massimo Candiani

    2013-01-01

    Strong evidence exists that the host's immune system plays a crucial role for the development of human papillomavirus-related cervical premalignant and malignant lesions. In particular, effective cell-mediated immunity (CMI) promotes spontaneous infection clearance and cancer precursors regression in healthy subjects, while immunosuppressed individuals are more likely to experience infection persistence, cervical intraepithelial neoplasia (CIN) lesions, and cervical cancer. In this study, the...

  11. Economic burden of vulvar and vaginal intraepithelial neoplasia: retrospective cost study at a German dysplasia centre

    Directory of Open Access Journals (Sweden)

    Kok Patrick

    2011-03-01

    Full Text Available Abstract Background Human papillomavirus is responsible for a variety of diseases including grade 2 and 3 vulvar and vaginal intraepithelial neoplasia. The aim of this study was to assess parts of the burden of the last diseases including treatment costs. The direct medical resource use and cost of surgery associated with neoplasia and related diagnostic procedures (statutory health insurance perspective were estimated, as were the indirect costs (productivity losses associated with surgical treatment and related gynaecology visits for diagnostic purposes. Methods Data from 1991-2008 were retrospectively collected from patient records of the outpatient unit of the Gynaecological Dysplasia Clinic, Heinrich Heine University, Dusseldorf, Germany. Two subgroups of patients were analysed descriptively: women undergoing one surgical procedure related to a diagnosis of vulvar and/or vaginal intraepithelial neoplasia, and women undergoing two or more surgical procedures. Target measures were per-capita medical resource consumption, direct medical cost and indirect cost. Results Of the 94 women analysed, 52 underwent one surgical intervention and 42 two or more interventions (mean of 3.0 interventions during the total period of analysis. Patients undergoing one surgical intervention accrued €881 in direct costs and €682 in indirect costs; patients undergoing more than one intervention accrued €2,605 in direct costs and €2,432 in indirect costs. Conclusions The economic burden on German statutory health insurance funds and society induced by surgical interventions and related diagnostic procedures for grade 2/3 vulvar and vaginal neoplasia should not be underrated. The cost burden is one part of the overall burden attributable to human papillomavirus infections.

  12. Spermatozoa-li ke cell invaders, nuclear vlimata, in human neoplasia

    OpenAIRE

    1993-01-01

    Spermatozoa-like cells (nuclear vlimata) have been identified in malignant cell cultures and embryonic cells, also common in the cytology and histology of all types of human neoplasia even after chemotherapy. A new mechanism of invasion of malignant cells has been described, according to which neoplastic cells behave and function as parasites using host-cells to divide, survive and eventually produce nuclear vlimata (bullets). Nuclear vlimata are the end ce...

  13. Acute renal failure as an initial manifestation of Multiple Endocrine Neoplasia (MEN Type 1

    Directory of Open Access Journals (Sweden)

    Reza Afshar

    2012-01-01

    Full Text Available Multiple endocrine neoplasia (MEN is a group of heritable syndromes characterized by aberrant growth of benign or malignant tumors in a subset of endocrine tissues. There are three major syndromes: MEN1, 2A and 2B. We describe a 60-year-old woman who initially manifested acute renal failure due to hypercalcemia and dehydration and, finally, was diagnosed as a sporadic MEN1 case.

  14. Plasma matrix metalloproteinase 9 as an early surrogate biomarker of advanced colorectal neoplasia.

    Science.gov (United States)

    Gimeno-García, Antonio Z; Triñanes, Javier; Quintero, Enrique; Salido, Eduardo; Nicolás-Pérez, David; Adrián-de-Ganzo, Zaida; Alarcón-Fernández, Onofre; Abrante, Beatriz; Romero, Rafael; Carrillo, Marta; Ramos, Laura; Alonso, Inmaculada; Ortega, Juan; Jiménez, Alejandro

    2016-01-01

    Matrix metalloproteinases (MMPs) are overexpressed at different stages of colorectal carcinogenesis and could serve as early surrogate biomarkers of colorectal neoplasia. To assess the utility of plasma MMP2 and MMP9 levels in the detection of advanced colorectal neoplasia and their correlation with tissue levels. We analysed blood and tissue samples from patients with non-advanced adenomas (n=25), advanced adenomas (n=25), colorectal cancer (n=25) and healthy controls (n=75). Plasma and tissue gelatinase levels were determined by Luminex XMAP technology and gelatin zymography. Receiver operating characteristic (ROC) curve analysis was used to calculate the optimum cut-off for the detection of advanced colorectal neoplasia. Plasma MMP2 levels were similar between groups whatever the type of lesion. Plasma MMP9 levels were significantly higher in patients with neoplastic lesions than in healthy controls (median 292.3ng/ml vs. 139.08ng/ml, P<0.001). MMP9 levels were also higher in colorectal cancer than in non-advanced adenomas (median 314.6ng/ml vs. 274.3ng/ml, P=0.03). There was a significant correlation between plasma and tissue levels of MMP9 (r=0.5, P<0.001). The plasma MMP9 cut-off range with the highest diagnostic accuracy was between 173ng/ml and 204ng/ml (AUC=0.80 [95% CI: 0.72-0.86], P<0.001; sensitivity, 80-86% and specificity, 57-67%). Plasma MMP9 could be a surrogate biomarker for the early detection of advanced colorectal neoplasia, although its diagnostic performance could be increased by combination with other biomarkers. Copyright © 2015 Elsevier España, S.L.U. y AEEH y AEG. All rights reserved.

  15. Mild Obesity, Physical Activity, Calorie Intake, and the Risks of Cervical Intraepithelial Neoplasia and Cervical Cancer

    OpenAIRE

    Jae Kwan Lee; So, Kyeong A; Piyathilake, Chandrika J.; Mi Kyung Kim

    2013-01-01

    OBJECTIVE: We investigated whether obesity, physical activity, and calorie intake are associated with the risks of cervical intraepithelial neoplasia (CIN) and cervical cancer. METHODS: We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic regression models were used to estimate crude and multivariate odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs), and to assess whether body mass index...

  16. Cervical glandular atypia associated with squamous intraepithelial neoplasia: a premalignant lesion?

    OpenAIRE

    Brown, L J; Wells, M

    1986-01-01

    Recent studies have described premalignant changes in the endocervical epithelium, but morphological criteria for the diagnosis of cervical glandular atypia of lesser severity than adenocarcinoma in situ have not been established. Adenocarcinoma in situ is often associated with cervical intraepithelial neoplasia (CIN). The endocervical mucosa in 105 cases of CIN grade III was evaluated and compared with that of 100 controls. Sixteen cases of cervical glandular atypia and one case of adenocarc...

  17. Neoplasia in felids at the Knoxville Zoological Gardens, 1979-2003.

    Science.gov (United States)

    Owston, Michael A; Ramsay, Edward C; Rotstein, David S

    2008-12-01

    A review of medical records and necropsy reports from 1979-2003 found 40 neoplasms in 26 zoo felids, including five lions (Panthera leo, two males and three females), three leopards (Panthera pardus, two males and one female), one jaguar (Panthera onca, female), 11 tigers (Panthera tigris, three males and eight females), two snow leopards (Panthera uncia, one male and one female), two cougars (Felis concolor, one male and one female), one bobcat (Felis rufus, male), and one cheetah (Acinonyx jubatus, female). Animals that had not reached 3 yr of age or had been housed in the collection less than 3 yrs were not included in the study. Neoplasia rate at necropsy was 51% (24/47), and overall incidence of felid neoplasia during the study period was 25% (26/103). Neoplasia was identified as the cause of death or reason for euthanasia in 28% (13/47) of those necropsied. Neoplasms were observed in the integumentary-mammary (n=11), endocrine (n=10), reproductive (n=8), hematopoietic-lymphoreticular (n=5), digestive (n=3), and hepatobiliary (n=2) systems. One neoplasm was unclassified by system. Multiple neoplasms were observed in 11 animals. Both benign and malignant neoplasms were observed in all systems except for the hematopoietic-lymphoreticular systems where all processes were malignant. Of the endocrine neoplasms, those involving the thyroid and parathyroid glands predominated (n=8) over other endocrine organs and included adenomas and carcinomas. In the integumentary system, 63% (7/11) of neoplasms involved the mammary gland, with mammary carcinoma representing 83% (6/7) of the neoplasms. The rates of neoplasia at this institution, during the given time period, appears to be greater than rates found in the one other published survey of captive felids.

  18. Multiple endocrine neoplasia type 2 (Sipple's syndrome): clinical and cytogenetic analysis of a kindred.

    OpenAIRE

    Zatterale, A.; Stabile, M; Nunziata, V; Di Giovanni, G.; Vecchione, R; Ventruto, V

    1984-01-01

    This report describes the clinical and cytogenetic analysis of a kindred with multiple endocrine neoplasia type 2 (MEN-2 or Sipple's syndrome) in two generations. Medullary thyroid carcinoma was present in five members either as a large or as an occult tumour. Phaeochromocytoma was demonstrated in one severely hypertensive relative and urine vanillylmandelic acid (VMA) was increased in one normotensive member. Serum parathormone (PTH) was normal in all but one normocalcaemic patient of this f...

  19. Does Postevacuation β -Human Chorionic Gonadotropin Level Predict the Persistent Gestational Trophoblastic Neoplasia?

    OpenAIRE

    2014-01-01

    β -human chorionic gonadotropin (HCG) level is not a reliable marker for early identification of persistent gestational trophoblastic neoplasia (GTN) after evacuation of hydatidiform mole. Thus, this study was conducted to evaluate β -HCG regression after evacuation as a predictive factor of malignant GTN in complete molar pregnancy. Methods. In this cross-sectional study, we evaluated a total of 260 patients with complete molar pregnancy. Sixteen of the 260 patients were excluded. Serum leve...

  20. Las especies invasoras vertebradas

    OpenAIRE

    Monge Meza, Javier

    2016-01-01

    Se presenta la definición de especie invasora, así como diversos enfoques relacionados con la temática. Se indican las etapas del proceso de invasión biológica y las limitaciones para que muchas de las especies lo concreten, así como la importancia de la participación humana. Se hace referencia a los impactos de las especies vertebradas invasoras y las supuestas repercusiones para la biodiversidad, así como a las opiniones divergentes en cuanto a su verdadero efecto, en virtud de los datos qu...

  1. Características de um grupo de adolescentes com suspeita de neoplasia intra-epitelial cervical Characteristics of a group of adolescents with suspected cervical intraepithelial neoplasia

    Directory of Open Access Journals (Sweden)

    Maria Isabel do Nascimento

    2005-10-01

    Full Text Available OBJETIVO: avaliar a prevalência de alterações citológicas, colposcópicas e histopatológicas observadas no colo uterino de adolescentes com suspeita de neoplasia cervical e as correlações epidemiológicas, compararando com mulheres adultas jovens. MÉTODOS: estudo transversal, retrospectivo de revisão de 366 prontuários de mulheres encaminhadas para esclarecimento diagnóstico com suspeita de neoplasia cervical. As pacientes foram classificadas em dois grupos definidos por idade. O grupo Adolescente foi composto por 129 mulheres de 13 a 19 anos e o grupo Adulta foi composto por 237 mulheres de 20 a 24 anos. Foram calculados razão de prevalência (RP, respectivos intervalos de confiança (IC a 95% para cada variável, teste chi2 ou teste exato de Fisher quando aplicável para comparação das proporções. RESULTADOS: a sexarca ocorreu em média aos 15,0 anos no grupo Adolescente e 16,6 anos no grupo Adulta. A chance de diagnóstico de alterações citológicas no primeiro exame realizado (RP=2,61; IC 95%: 2,0-3,4, a condição neoplasia intra-epitelial cervical (NIC a esclarecer (RP=1,78; IC 95%: 1,26-2,52 e a colposcopia de baixo grau (RP=1,42; IC 95%: 1,08-1,86 foram estatisticamente significantes no grupo Adolescente. A análise histopatológica não mostrou diferenças para qualquer grau de NIC. Entretanto, foram identificados dois casos de carcinoma microinvasor, sendo um em cada grupo, e três casos de carcinoma invasor no grupo Adulta. CONCLUSÃO: nosso estudo sugere que o câncer de colo uterino é raro na adolescência, mas verificamos que alterações a ele associadas aconteceram em mulheres muito jovens. A investigação da neoplasia intra-epitelial cervical com a aplicação criteriosa dos mesmos métodos utilizados para a mulher adulta foi apropriada também na adolescência.PURPOSE: to evaluate the prevalence of cytologic, colposcopic and histopathologic alterations observed in the uterine cervix of adolescents with

  2. Tratamiento con electrocauterización de las lesiones premalignas del cérvix

    OpenAIRE

    Israel Meza G.

    2014-01-01

    Se presentaron los resultados del tratamiento con electrocauterización de las neoplasias intraepiteliales del cérvix en 430 pacientes atendidas en el Hospital Universitario del Valle, en el Hospital San Juan de Dios y en el Centro Hospital Cañaveralejo en Cali, Colombia, entre 1982 y 1992. Inicialmente se seleccionaron 455 mujeres que consultaron con citologías anormales (inclusive Papanicolau II) con cambios coilocíticos y atipias inflamatorias. Para el análisis final sólo se incluyeron 430 ...

  3. Importance of thoracic radiography in the approach of animals with neoplasia/ A importância do exame radiográfico torácico na abordagem de animais portadores de neoplasias

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Faria dos Reis

    2008-08-01

    Full Text Available The aim of the present study was to evaluate the importance of the thoracic radiography in dogs and cats with neoplasias of diverse origins and localizations, excepting mammary neoplasm. It was studied 54 animals on suspicion of pulmonary metastase and/or primary lung tumors- 49 dogs (91% and five cats (9%; being 28 (52% female (3 cats and 26 (48% male (2 cats – attended by Thoracic and Oncology Medicine Services in the Veterinary Hospital/UEL, in 2005. The mammary neoplasias were not included in this work. From the 54 animals, six (11% presented radiography examinations with evidence of pulmonary metastase, being one cat. Four animals (8% had compatible radiography examination with primary pulmonary neoplasia. These results indicate the importance of the thoracic radiography in the approach of animals with neoplasia, to exclude the possibility of pulmonary metastase independent from the neoplasm origin and the necessity of radiographic attendance to the animals without radiographic signals of pulmonary metastase.O objetivo deste trabalho foi avaliar a importância do exame radiográfico torácico em cães e gatos com neoplasias de diversas origens e localizações, excetuando neoplasias mamárias. Foram estudados 54 animais com suspeita de metástase pulmonar e/ou neoplasia pulmonar primária – 49 cães (91% e cinco felinos (9%; sendo 28 (52% fêmeas (3 felinas e 26 (48% machos (2 felinos – atendidos nos Projetos de Extensão em Medicina Torácica e Oncologia do Hospital Veterinário/UEL, durante o ano de 2005. As neoplasias mamárias, não foram inclusas neste trabalho. Dos 54 animais, seis (11% apresentaram exames radiográficos com evidência de metástase pulmonar, sendo um felino. Quatro animais (8% tiveram exame radiográfico compatível com neoplasia pulmonar primária. Esses resultados indicam a importância do exame radiográfico torácico na abordagem de animais com neoplasias, para descartar a possibilidade de met

  4. Las incubadoras de las empresas de Quebec

    Directory of Open Access Journals (Sweden)

    Bernardo Parra Restrepo

    1993-01-01

    Full Text Available Este articulo contiene información de las incubadoras de empresas especialmente aquellas encontradas en Quebec. A través de los 80's, el concepto de incubadoras de empresas fue introducido en América por expertos en el desarrollo económico. Sus metas fueron el estudio de los efectos del desempleo resultante de la quiebra de plantas industriales o del uso del proceso de producción automático por parte de las grandes compañías. Además se esperaba crear empleo para los inmigrantes. El campo más prometedor de estas experiencias se encuentra en el desarrollo de alta tecnología industrial, especialmente en electrónica, microprocesadores y software para sistemas de computación. Esta área también cubre las industrias innovadoras.

  5. The diagnostic value of exfoliative cytology vs histopathology for ocular surface squamous neoplasia.

    Science.gov (United States)

    Semenova, Ekaterina A; Milman, Tatyana; Finger, Paul T; Natesh, Sribhargava; Kurli, Madhavi; Schneider, Susan; Iacob, Codrin E; McCormick, Steven A

    2009-11-01

    To determine the reliability and role of conjunctival exfoliative cytologic and histopathologic diagnosis of biopsied tissue in ocular surface squamous neoplasia. Retrospective review of an interventional case series of patients biopsied and treated for squamous conjunctival and corneal neoplasia. Forty-nine patients who underwent conjunctival cytologic analysis (n = 36), conjunctival biopsy (n = 35), or both were evaluated. For the purposes of this study, three ocular pathologists reviewed the results of cytologic and biopsied tissue in a masked fashion. Evaluation of cytologic smears revealed a 91% concordance in interpretation of conjunctival cytologic material as no dysplasia vs dysplasia. The concordance dropped to 59% in grading the degree of dysplasia. The cytologic material was found to be inadequate for interpretation in 1 case. Evaluation of subsequent biopsy revealed a 98% concordance between the pathologists in interpretation of biopsied tissue as no dysplasia vs any degree of dysplasia. The concordance decreased to 83% in grading the degree of dysplasia. Cytologic evaluation was capable of distinguishing a neoplastic from nonneoplastic process before tissue biopsy in 80% of cases. Ocular surface cytologic analysis is a simple, safe, and relatively noninvasive diagnostic tool. It was found helpful in detecting dysplasia before surgical resection. It was used in the settings of recurrent tumor and for follow-up care of patients treated with topical chemotherapy. Although cytologic smears cannot replace incisional or excisional biopsy for definitive diagnosis, exfoliative cytologic analysis can play an important role in the diagnosis and management of patients with ocular surface squamous neoplasia.

  6. Human papilloma virus identification in breast cancer patients with previous cervical neoplasia

    Directory of Open Access Journals (Sweden)

    James Sutherland Lawson

    2016-01-01

    Full Text Available Purpose: Women with human papilloma virus (HPV associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i identify high risk for cancer HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii determine if these HPVs were biologically active.Methods: A range of polymerase chain reaction (PCR and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients. Results: The same high risk HPV types were identified in both the cervical and breast specimens in 13 (46% of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically active as demonstrated by the expression of HPV E7 proteins and the presence of HPV associated koilocytes. The average age of these patients diagnosed with breast cancer following prior cervical precancer was 51 years, as compared to 60 years for all women with breast cancer (p for difference = 0.001. Conclusions: These findings indicate that high risk HPVs can be associated with cervical neoplasia and subsequent young age breast cancer. However these associations are unusual and are a very small proportion of breast cancers. These outcomes confirm and extend the observations of 2 similar previous studies and offer one explanation for the increased prevalence of serious invasive breast cancer among young women.

  7. Turner syndrome and meningioma: support for a possible increased risk of neoplasia in Turner syndrome.

    Science.gov (United States)

    Pier, Danielle B; Nunes, Fabio P; Plotkin, Scott R; Stemmer-Rachamimov, Anat O; Kim, James C; Shih, Helen A; Brastianos, Priscilla; Lin, Angela E

    2014-01-01

    Neoplasia is uncommon in Turner syndrome, although there is some evidence that brain tumors are more common in Turner syndrome patients than in the general population. We describe a woman with Turner syndrome (45,X) with a meningioma, in whom a second neoplasia, basal cell carcinomas of the scalp and nose, developed five years later in the absence of therapeutic radiation. Together with 7 cases of Turner syndrome with meningioma from a population-based survey in the United Kingdom, and 3 other isolated cases in the literature, we review this small number of patients for evidence of risk factors related to Turner syndrome, such as associated structural anomalies or prior treatment. We performed histological and fluorescent in situ hybridization (FISH) of 22q (NF2 locus) analyses of the meningeal tumor to search for possible molecular determinants. We are not able to prove causation between these two entities, but suggest that neoplasia may be a rare associated medical problem in Turner syndrome. Additional case reports and extension of population-based studies are needed.

  8. Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders

    Institute of Scientific and Technical Information of China (English)

    Cataldo Di Bisceglie; Angela Bertagna; Emanuela R Composto; Fabio Lanfranco; Matteo Baldi; Giovanna Motta; Anna M Barberis

    2013-01-01

    Pretherapy sperm cryopreservation in young men is currently included in good clinical practice guidelines for cancer patients.The aim of this paper is to outline the effects of different oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders,based on an 8-year experience of the Cryopreservation Centre of a large public hospital.Two hundred and sixty-one patients with testicular neoplasia and 219 patients with lymphoproliferative disorders who underwent chemotherapy and/or radiotherapy and pretherapy semen cryopreservation were evaluated.Sperm and hormonal parameters (follicle-stimulating hormone (FSH),luteinizing hormone (LH),testosterone,inhibin B levels) were assessed prior to and 6,12,18,24 and 36 months after the end of cancer treatment.At the time of sperm collection,baseline FSH level and sperm concentration were impaired to a greater extent in patients with malignant testicular neoplasias than in patients with lymphoproliferative disorders.Toxic effects on spermatogenesis were still evident at 6 and 12 months after the end of cancer therapies,while an improvement of seminal parameters was observed after 18 months.In conclusion,an overall increase in sperm concentration was recorded about 18 months after the end of cancer treatments in the majority of patients,even if it was not possible to predict the evolution of each single case ‘a priori'.For this reason,pretherapy semen cryopreservation should be considered in all young cancer patients.

  9. Chlamydia trachomatis infection and human papillomavirus in women with cervical neoplasia in Pernambuco-Brazil.

    Science.gov (United States)

    Tavares, Mayara Costa Mansur; de Macêdo, Jamilly Lopes; de Lima Júnior, Sérgio Ferreira; de Andrade Heráclio, Sandra; Amorim, Melânia Maria Ramos; de Mascena Diniz Maia, Maria; de Souza, Paulo Roberto Eleutério

    2014-02-01

    Chlamydia trachomatis (CT) is the most common bacterial cause of sexually transmitted disease. High-risk human papillomavirus (HR-HPV) is considered the main etiological agent for cervical neoplasia. Evidences showed that the presence of co-infection of CT and HR-HPV plays a central role in the etiology of cervical intraepithelial neoplasia (CIN) and cervical cancer. The goals of this study were: evaluate the human papillomavirus (HPV) and CT prevalence among Brazilian women with abnormal cytology and provide the effect of this association on the severity of cervical neoplasia. The population of this study was composed by 142 women with incident histological incidence of CIN grades I, II, III or cervical cancer from Recife, Northeast of Brazil. The polymerase chain reaction method on a cervical brush specimen was used to detect both agents and the automatic sequencing method was used for HPV genotyping assay. The prevalence of HPV and CT was 100 and 24.65 %, respectively. Thirteen types of HPV were detected; HPV 16, 18, 31 and 33 were the most common. The most prevalent HPV types were HPV 16 and 18. A significant association between CT positive and HPV 16 infection was found (p infections, with high-risk types being the most common. Also, the data collected suggest that CT infection may play an important role in the natural history of HPV infection.

  10. Inflammation and Atrophy Precede Prostate Neoplasia in PhIP Induced Rat Model

    Energy Technology Data Exchange (ETDEWEB)

    Borowsky, A D; Dingley, K; Ubick, E; Turteltaub, K; Cardiff, R D; DeVere-White, R

    2006-06-01

    2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) has been implicated as a major mutagenic heterocyclic amine in the human diet and is carcinogenic in the rat prostate. In order to validate PhIP induced rat prostate neoplasia as a model of human prostate cancer progression, we sought to study the earliest histologic and morphologic changes in the prostate and to follow the progressive changes over time. We fed 67 male Fischer F344 5 week old rats with PhIP (400 PPM) or control diets for 20 weeks, and then sacrificed animals for histomorphologic examination at age 25 weeks, 45 weeks, and 65 weeks. Animals treated with PhIP showed significantly more inflammation (P=.002 (25wk), >.001(45wk), .016(65wk)) and atrophy (P=.003(25wk), >.001(45wk), .006 (65wk)) in their prostate glands relative to controls. Prostatic intraepithelial neoplasia (PIN) occurred only in PhIP treated rats. PIN lesions arose in areas of glandular atrophy, most often in the ventral prostate. Atypical cells in areas of atrophy show loss of glutathione S-transferase pi immunostaining preceding development of PIN. None of the animals in this study developed invasive carcinomas differing from previous reports. Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP treated rat prostate proceeds from inflammation to post-inflammatory proliferative atrophy to PIN.

  11. [Usefulness of human papillomavirus testing in anal intraepithelial neoplasia screening in a risk behaviour population].

    Science.gov (United States)

    Padilla-España, Laura; Repiso-Jiménez, Bosco; Fernández-Sánchez, Fernando; Frieyro-Elicegui, Marta; Fernández-Morano, Teresa; Pereda, Teresa; Rivas-Ruiz, Francisco; Redondo, Maximino; de-Troya Martín, Magdalena

    2014-11-01

    The incidence of intraepithelial anal neoplasia is increasing in certain risk behaviour groups, and human papillomavirus (HPV) infection is involved in its pathogenesis. The systematic use of anal cytology, and more recently HPV detection by hybrid capture and genotyping, have been introduced into screening programs in recent decades. A retrospective cohort study was carried out on individuals with risk behaviours of developing intraepithelial anal neoplasia and who attended Sexually Transmitted Infections clinics in the Dermatology area of the Hospital Costa del Sol from January 2010 to December 2012. The intraepithelial anal neoplasia screening was performed using anal cytology and HPV genotyping. Half (50%) of the study population were HIV positive. A high frequency of anal dysplasia and presence of HPV in cytology (82.1%) and genotype (79%) was found. A statistically significant association (P<.005) was obtained between the presence of high-risk HPV genotypes and the presence of high-grade dysplasia in the second directed cytology. HPV genotyping enabled 17 cases (22%) of severe dysplasia to be identified that were under-diagnosed in the first cytology. Cases of high-grade dysplasia can be under-diagnosed by a first anal cytology. Detection of HPV can supplement this procedure, leading to the identification of those patients most at risk of developing high-grade anal dysplasia. Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  12. Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

    Directory of Open Access Journals (Sweden)

    Alexander D. Borowsky

    2006-09-01

    Full Text Available 2-Amino-1-methyl-6-phenylimidazo(4,5-bpyridine (PhIP has been implicated as a major mutagenic heterocyclicamine in the human diet and is carcinogenic in the rat prostate. To validate PhIP-induced rat prostatic neoplasia as a model of human prostate cancer progression, we sought to study the earliest histologic and morphologic changes in the prostate and to follow progressive changes over time. We fed sixty-seven 5-week-old male Fischer F344 rats with PhIP (400 ppm or control diets for 20 weeks, and then sacrificed animals for histomorphologic examination at the ages of 25, 45, and 65 weeks. Animals treated with PhIP showed significantly more inflammation (P = .002, > .001, and .016 for 25, 45, and 65 weeks, respectively and atrophy (P = .003, > .001, and .006 for 25, 45, and 65 weeks, respectively in their prostate glands relative to controls. Prostatic intraepithelial neoplasia (PIN occurred only in PhIP-treated rats. PIN lesions arose in areas of glandular atrophy, most often in the ventral prostate. Atypical cells in areas of atrophy show loss of glutathione S-transferase π immunostaining preceding the development of PIN.None of the animals in this study developed invasive carcinomas, differing from those in previous reports. Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP-treated rat prostate proceeds from inflammation to postinflammatory proliferative atrophy to PIN.

  13. Las sentencias constitucionales exhortativas

    Directory of Open Access Journals (Sweden)

    Néstor Pedro Sagües

    2006-01-01

    Full Text Available Como producto del derecho judicial, diferentes tribunales constitucionales europeos han desarrollado nuevos tipos de sentencias atípicas, diferentes de las tradicionales. Entre ellas, las “exhortativas” recomiendan al legislador (incluso al constituyente dictar nuevas normas en reemplazo de las actualmente en vigor, para que estén bajo la Constitución. En el caso argentino, recientemente la Corte Suprema las ha admitido en un hábeas corpus colectivo destinado a mejorar la situación de detenidos en cárceles de la Provincia de Buenos Aires.

  14. Las fronteras del istmo

    OpenAIRE

    2013-01-01

    Obra organizada en torno a seis ejes principales que estudian la importancia de comparar las fronteras y los tipos de gestión desde el punto de vista geopolítico, histórico y antropológico; las tramas de la organización del espacio actual; la influencia en la evolución de las sociedades debido a la violencia política y los conflictos armados; los movimientos migratorios internacionales; la integración política y económica y finalmente los lazos comunitarios y de las identidades relacionados c...

  15. las Comunicaciones (tics

    Directory of Open Access Journals (Sweden)

    Fernando Iriarte Díazgranados

    2007-01-01

    Full Text Available En este artículo se presenta un análisis de los resultados de estudios sobre la penetración de las Tecnologías de la Información y las Comunicaciones (TICS en países como España y Colombia. El análisis se centra en las posibles consecuencias, tanto positivas como negativas, que estas tecnologías pueden tener en la vida de los niños, y en el papel que las familias pueden asumir para que su utilización sea lo más beneficiosa posible.

  16. Las humanidades entre las cuerdas del neoliberalismo

    OpenAIRE

    Rodríguez Reyes, Abdiel

    2015-01-01

    Este  artículo problematiza la situación de las humanidades en el auge del neoliberalismo. Propone que para comprender el mundo moderno es necesario problematizar e interrelacionar los ámbitos del saber humanístico, científico y tecnológico. También crítica la visión que se tiene de la educación al servicio exclusivo de la sociedad de mercado y las élites financieras.

  17. Is there any association between hormonal contraceptives and cervical neoplasia in a poor Nigerian setting?

    Directory of Open Access Journals (Sweden)

    Ajah LO

    2015-07-01

    Full Text Available Leonard Ogbonna Ajah,1,2 Chibuike Ogwuegbu Chigbu,2 Benjamin Chukwuma Ozumba,2 Theophilus Chimezie Oguanuo,2 Paul Olisaemeka Ezeonu1 1Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Nigeria; 2Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Enugu, Nigeria Background: The association between hormonal contraception and cervical cancer is controversial. These controversies may hamper the uptake of hormonal contraceptives. Objective: To determine the association between hormonal contraceptives and cervical neoplasia. Materials and methods: This was a case-control study in which Pap-smear results of 156 participants on hormonal contraceptives were compared with those of 156 participants on no form of modern contraception. Modern contraception is defined as the use of such contraceptives as condoms, pills, injectables, intrauterine devices, implants, and female or male sterilization. Those found to have abnormal cervical smear cytology results were subjected further to colposcopy. Biopsy specimens for histology were collected from the participants with obvious cervical lesions or those with suspicious lesions on colposcopy. The results were analyzed with descriptive and inferential statistics at a 95% level of confidence. Results: A total of 71 (45.5%, 60 (38.5%, and 25 (16.0% of the participants on hormonal contraceptives were using oral contraceptives, injectable contraceptives, and implants, respectively. Cervical neoplasia was significantly more common among participants who were ≥35 years old (6% versus 1%, P<0.0001, rural dwellers (6% versus 3.5%, P<0.0001, unmarried (7.6% versus 3.5%, P<0.0001, unemployed (6.8% versus 3.5%, P<0.0001, less educated (6% versus 3.8%, P<0.0001, and had high parity (6.8% versus 3.6%, P<0.0001. There was no statistical significant difference in cervical neoplasia between the two groups of participants (7 [4.5%] versus 6 [3.8%], P=1.0. Conclusion

  18. Las ruinas y las sombras de Manderley

    Directory of Open Access Journals (Sweden)

    Donapetry Camacho, María

    2010-02-01

    Full Text Available The ruins and the shadows of Manderley explores possible reciprocal interpretative relations between Daphne du Maurier’s novel Rebecca and Alfred Hitchcock’s cinematic version. Some of the relevant aspects considered here are: the treatment of the Derridean “ruins of memory” within the novel and within Hitchcock himself, the differentiation and the confrontation of the protagonist as outsider vis á vis the world of Manderley’s insiders, the iconic and symbolic values of the literary text and its filmic visualization, and the ethical positions implied by the choice or rejection of certain narrative devices in both works.

    Las ruinas y las sombras de Manderley aborda posibles relaciones interpretativas recíprocas entre la novela de Daphne du Maurier Rebecca y la película homónima de Alfred Hitchcock. Algunos de los aspectos que se consideran relevantes en este estudio son: el tratamiento de las “ruinas de la memoria” derridianas dentro de la novela y del propio Hitchcock, la diferenciación y el enfrentamiento de la protagonista “externa” con el mundo de los “internos” de Manderley, los valores icónicos y simbólicos del texto literario y de la visualización fílmica, y las posiciones éticas que implican la elección o el rechazo de ciertos recursos narrativos en ambas obras.

  19. Febre catarral maligna em bovinos no Rio Grande do Sul: epidemiologia, sinais clínicos e patologia Malignant catarrhal fever in cattle in Rio Grande do Sul, Brazil: epidemiology, clinical signs and pathology

    Directory of Open Access Journals (Sweden)

    Raquel R. Rech

    2005-06-01

    Full Text Available São descritos a epidemiologia, os sinais clínicos e os achados de necropsia e histopatológicos observados em casos de febre catarral maligna (FCM, que ocorreram de 1973 a 2003 em bovinos de 15 fazendas no Rio Grande do Sul. Em nove ocasiões (60%, a doença ocorreu de forma esporádica, afetando 1-3 bovinos por rebanho, enquanto, em seis fazendas (40%, a FCM ocorreu de forma epizoótica, afetando vários bovinos em cada rebanho. As taxas de morbidade variaram de 2,4% a 20%, e as taxas de letalidade foram de 83,3% a 100%. Bovinos de todas as idades e ambos os sexos foram afetados. Nos casos em que foi possível obter essa informação (9 fazendas, sempre havia ovinos em contato com os bovinos afetados, e o maior número de casos de FCM ocorreu na primavera e verão. A doença clínica era aguda ou subaguda, e os sinais clínicos incluíam febre, corrimento nasal e ocular, conjuntivite, salivação excessiva, hematúria, necrose das papilas bucais que se tornavam rombas, linfadenopatia, diarréia e distúrbios neurológicos. Os achados de necropsia incluíam opacidade da córnea, erosões e ulcerações em várias membranas mucosas do trato alimentar, respiratório, urogenital e conjuntiva; aumento de volume e hemorragia em linfonodos e múltiplos focos brancos nos córtices renais e nas tríades portais hepáticas. Dermatite crostosa foi observada em alguns casos. Os principais achados histopatológicos incluíam vasculite, necrose dos epitélios de revestimento e acúmulos de células inflamatórias em vários órgãos. A vasculite era associada com necrose fibrinóide da túnica média das artérias e acompanhada de infiltrado inflamatório constituído por linfoblastos, linfócitos, plasmócitos e macrófagos.The epidemiology, clinical signs, necropsy and histopathological findings in cases of malignant catarrhal fever (MCF occurring in cattle from 15 farms in Rio Grande do Sul, Brazil, from 1973 to 2003, are described. In 9 instances (60

  20. Vaporização a laser do cervix para tratamento da neoplasia intraepitelial cervical Laser vaporization of the cervix for the management of cervical intraepithelial neoplasia

    Directory of Open Access Journals (Sweden)

    Euridice Maria de Almeida Figueiredo

    1998-04-01

    Full Text Available O câncer cérvico-uterino é muito comum em vários países da América Latina. As estatísticas de mortalidade e as taxas de incidência demonstram a sua real importância. O cânver cérvico-uterino freqüentemente é uma doença progressiva iniciada com mudanças intra-epiteliais, que podem se transformar em um processo invasivo, sendo o nosso objetivo tratar precocemente estas lesões quando ainda é possível a cura de 100%. Em nosso estudo prospectivo foram selecionadas 21 pacientes com neoplasia cervical intra-epitelial reatreadas pela citplogia e diagnosticadas pela histopatologia após biópsia dirigida pela colposcopia. O método terapêutico empregado foi a vaporização a laser com o CO2. Tiveram como pré-requisito os seguintes critérios: informação segura pela colposcopia da zona de transformação e afastar a presença de câncer invasivo; a neoplasia epitelial cervical deve ocupar a ectocervix sem nenhuma extensão para o canal cervical e correlação positiva entre a citologia, colposcopia e histologia. O uso de laser CO2 com microscópio permitiu precisão na aplicação e com vantagens de ser um procedimento ambulatorial diminuindo estresse cirúrgico das pacientes. Foi realizado sem anestesia e com duração média de 15 minutos. A cicatrização completou-se em torno de três semanas e com cuidados operatórios mínimos. Somente dois casos tiveram sangramento vaginal discreto no quinto e décimo dia de pós-operatório, resolvido com tamponamento vaginal por 24 horas. A colposcopia, cirurgia e o seguimento foram feitos pelo autor, tendo uma paciente sido submetida a uma segunda vaporização no quinto mês de controle. Somente uma paciente teve recidiva no 26° mês de seguimento e complementará o tratamento. As vinte outras restantes estão em controle sem recidiva de doença. Em vista dos resultados obtivemos um percentual de cura de 95%, que coincide com a literatura. O uso de laser CO2 no tratamento das neoplasias

  1. Análise de polimorfismos e de expressão do gene p16INK4a em neoplasias cervicais

    OpenAIRE

    Sandra Liliana Vargas Torres

    2011-01-01

    O câncer de colo do útero é o segundo carcinoma mais frequente em mulheres no mundo e um dos cânceres femininos mais incidentes no Brasil. Em lesões pré-malignas e malignas do colo uterino, a proteína p16INK4a, que participa do controle do ciclo celular, apresenta um aumento considerável de sua expressão, devido possivelmente à presença de oncoproteínas do papilomavírus humano (HPV). Dois polimorfismos no gene p16INK4a, p16 500C>G e p16 540C>T, estão localizados na região 3 não traduzida (3UT...

  2. Detection of Human Papillomavirus Infection in Patients with Vaginal Intraepithelial Neoplasia.

    Science.gov (United States)

    Lamos, Cristina; Mihaljevic, Charlotte; Aulmann, Sebastian; Bruckner, Thomas; Domschke, Christoph; Wallwiener, Markus; Paringer, Carmen; Fluhr, Herbert; Schott, Sarah; Dinkic, Christine; Brucker, Janina; Golatta, Michael; Gensthaler, Lisa; Eichbaum, Michael; Sohn, Christof; Rom, Joachim

    2016-01-01

    Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It is a rare disease, representing less than 1% of all intraepithelial neoplasia of the female genital tract. Similar to cervical intraepithelial neoplasia (CIN), there are three different grades of VAIN. VAIN 1 is also known as a low-grade squamous intraepithelial lesion (LSIL), whereas VAIN 2 and VAIN 3 both represent high-grade squamous intraepithelial lesions (HSIL). Risk factors for the development of VAIN are similar to those for cervical neoplasia, i.e. promiscuity, starting sexual activity at an early age, tobacco consumption and infection with human papillomavirus (HPV). However, compared to other intraepithelial neoplasia such as CIN or VIN (vulvar intraepithelial neoplasia), there still is little understanding about the natural course of VAIN and its capacity for pro- or regression. Furthermore, there is controversial data about the HPV detection rate in VAIN lesions. 67 patients with histologically confirmed VAIN, who were diagnosed between 2003 and 2011 at the University Women´s Hospital of Heidelberg Germany, were included in this study. The biopsies of all participating patients were subjected to HPV genotyping. GP-E6/E7 Nested Multiplex PCR (NMPCR) was used to identify and genotype HPV. Eighteen pairs of type-specific nested PCR primers were assessed to detect the following "high-risk" HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68, as well as the "low-risk" genotypes 6/11, 42, 43 and 44. The data was analyzed with the software SAS (Statistical Analysis System). All 67 cases were eligible for DNA analysis. The median age was 53 years. The largest group with 53% (n = 36) was formed by women, who were first diagnosed with VAIN between the age of 41 to 60 years. 50% (n = 37) of the patients presented a VAIN in the upper 1/3 of the vagina. 58 (87%) were diagnosed with HSIL (VAIN). The median age in patients with LSIL

  3. en las redes organizacionales

    Directory of Open Access Journals (Sweden)

    Tania Peña

    2006-01-01

    Full Text Available Partiendo de una perspectiva racional, que luego llega a la abducción, se analiza la contribución de las unidades de información en las redes organizacionales generadoras de conocimiento; para esto se manejan algunos postulados teóricos que caracterizan y señalan tanto las funciones de las unidades de información en la actual sociedad globalizada, como el funcionamiento de las redes organizacionales. Como resultado se indica que las unidades de información contribuyen en los procesos de transferencia y creación de conocimiento que ocurre en dichas redes, en tanto que su acción impacta positivamente el desempeño de sus participantes. Se concluye primordialmente que las unidades de información propician el incremento del potencial creativo de los individuos que se manejan en ambientes redificados, por cuanto le proporcionan herramientas instrumentales tecnológico- analíticas para hacer un uso más provechoso de las fuentes de información, por lo que agregan valor a sus aportes intelectuales en la solución de problemas, el mejoramiento de procesos o la creación de innovaciones.

  4. Causas de las discapacidades

    OpenAIRE

    Jiménez Lara, Antonio; Huete García, Agustín

    2002-01-01

    En este documento se ofrece información sobre las causas de las deficiencias, clasificadas de acuerdo con la siguiente categorización: congénito; problemas en el parto; accidente de tráfico; accidente doméstico; accidente de ocio; accidente laboral; otro tipo de accidente; enfermedad común; enfermedad profesional y otras causas.

  5. Características clínicas y microbiológicas de los pacientes neutropénicos febriles con neoplasias hematológicas

    Directory of Open Access Journals (Sweden)

    Fabián Alberto Jaimes Barragán

    2008-02-01

    Full Text Available Se estudiaron en forma retrospectiva 441 historias clínicas en el período comprendido entre enero de 2003 y diciembre de 2005. De éstas, se identificaron las características de 117 episodios de neutropenia febril en 96 pacientes. La mediana de edad fue 34 años y el 56,4% de los episodios ocurrieron en hombres. Las más frecuentes neoplasias hematológicas relacionadas con neutropenia febril fueron leucemia linfoide aguda (LLA y leucemia mieloide aguda (LMA con 45 episodios de cada una, que corresponden al 76,9%. La mediana de duración de la neutropenia fue 8 días y el 60,7% de los casos entraron en la categoría de neutropenia grave. La mortalidad global fue del 32% y el 81,5% de estas muertes estuvieron asociadas directamente con la infección. Se obtuvo aislamiento microbiológico en el 51% de los eventos. Los bacilos gram negativos (BGN constituyeron el 59% de los aislamientos microbiológicos y los cocos gram positivos el 32%. El 14,3% de los BGN aislados fueron positivos para beta lactamasas de espectro extendido (BLEE y la resistencia global a ciprofloxacina alcanzó el 31,4%. El esquema antimicrobiano empírico más frecuentemente utilizado fue ciprofloxacina más ceftriaxona; la respuesta terapéutica fue desfavorable en 65% de los casos. En el Hospital San Vicente de Paúl de Medellín siguen primando los gérmenes gram negativos y son altas las tasas de resistencia a los antibióticos utilizados tradicionalmente como de primera línea, lo que sugiere la necesidad de reevaluar la pertinencia de estos esquemas.

  6. Adenocarcinoma mucinoso de pelvis renal. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Caridad Socorro Castro

    2012-02-01

    Full Text Available Las neoplasias malignas del riñón representan alrededor del 2 % de todos los cánceres, el carcinoma de células renales es el más frecuente dentro de este grupo con una frecuencia del 80 al 90 %. El adenocarcinoma de pelvis renal es una neoplasia muy rara, que se presenta en menos del 1 % de los pacientes con neoplasias malignas renales, asociada, la mayoría de las veces, a procesos inflamatorios del  órgano y litiasis. Por tales razones se decidió la publicación de un caso clínico diagnosticado  en el Departamento de Anatomía Patológica del Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, con esta variante histológica de cáncer renal, en una mujer en la cuarta década de la vida.

  7. Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia

    Directory of Open Access Journals (Sweden)

    Kleberg Karen

    2012-06-01

    Full Text Available Abstract Background The pathogenesis of colorectal neoplasia is still unresolved but has been associated with alterations in epithelial clearance of xenobiotics and metabolic waste products. The aim of this study was to functionally characterize the transport of cyclic nucleotides in colonic biopsies from patients with and without colorectal neoplasia. Methods Cyclic nucleotides were used as model substrates shared by some OATP- and ABC-transporters, which in part are responsible for clearance of metabolites and xenobiotics from the colonic epithelium. On colonic biopsies from patients with and without colorectal neoplasia, molecular transport was electrophysiologically registered in Ussing-chamber set-ups, mRNA level of selected transporters was quantified by rt-PCR, and subcellular location of transporters was determined by immunohistochemistry. Results Of four cyclic nucleotides, dibuturyl-cAMP induced the largest short circuit current in both patient groups. The induced short circuit current was significantly lower in neoplasia-patients (p = 0.024. The observed altered transport of dibuturyl-cAMP in neoplasia-patients could not be directly translated to an observed increased mRNA expression of OATP4A1 and OATP2B1 in neoplasia patients. All other examined transporters were expressed to similar extents in both patient groups. Conclusions OATP1C1, OATP4A1, OATP4C1 seem to be involved in the excretory system of human colon. ABCC4 is likely to be involved from an endoplasmic-Golgi complex and basolateral location in goblet cells. ABCC5 might be directly involved in the turnover of intracellular cAMP at the basolateral membrane of columnar epithelial cells, while OATP2B1 is indirectly related to the excretory system. Colorectal neoplasia is associated with lower transport or sensitivity to cyclic nucleotides and increased expression of OATP2B1 and OATP4A1 transporters, known to transport PGE2.

  8. Disparities in prevalence, location, and shape characteristics of colorectal neoplasia between South Korean and U.S. patients.

    Science.gov (United States)

    Cha, Jae Myung; Kozarek, Richard A; La Selva, Danielle; Gluck, Michael; Ross, Andrew; Chiorean, Michael; Koch, Johannes; Lin, Otto S

    2015-12-01

    Colon cancer screening is being introduced in many countries, but standard Western screening approaches may not be appropriate for Asian societies if differences in colon cancer epidemiology exist. Comparative analysis of colorectal neoplasia patterns in South Korean and Western subjects has implications for appropriate screening approaches in non-Western societies. The results of concurrent screening colonoscopies performed in average-risk patients 50 to 69 years old in 2 teaching hospitals, Kyung Hee University Hospital (Seoul, South Korea) and Virginia Mason Medical Center (Seattle, Wash), were compared with respect to prevalence, histologic features, anatomic distribution, and shape characteristics of colorectal neoplasia. The U.S. (n = 3460) and South Korean (n = 2193) cohorts were similar with regard to the prevalence of adenomas (28.5% vs 29.8%, respectively, P = .312) and advanced neoplasia (6.4% vs 5.4%, respectively, P = .102), but the proportion of proximal adenomas was greater in the U.S. cohort (62.8% vs 45.9%, P prevalence of adenomas and advanced neoplasia was similar in male patients, but there was a greater prevalence of neoplasia (23.5% vs 18.8%, P = .006) and advanced neoplasia (5.1% vs 2.7%, P prevalence of large flat adenomas in the U.S. cohort was 5 times that of the South Korean cohort (2.6% vs 0.5%, P prevalence of large flat adenomas. South Korean women have a lower prevalence of colorectal neoplasia than Western women. Such disparities suggest that Western screening strategies cannot be directly adopted by other countries, but need to be customized by society. Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  9. Condyloma Acuminatum, Anal Intraepithelial Neoplasia, and Anal Cancer in the Setting of HIV: Do We Really Understand the Risk?

    Science.gov (United States)

    Fazendin, Edward A; Crean, Alexander J; Fazendin, Jessica M; Kucejko, Robert J; Gill, Harkenwar S; Poggio, Juan L; Stein, David E

    2017-10-01

    The gold standard for surveillance of patients with anal lesions is unclear. The aim of this study was to stratify patients for risk of progression of disease and to determine appropriate intervals for surveillance of patients with anal disease. This was a retrospective chart review for patients treated for anal lesions between 2007 and 2014. Only patients with ≥1 year of follow-up from index evaluation, pathology, documented physical examination, and anoscopy findings were included for analysis. The study was conducted at an urban university hospital. HIV-positive patients with anal lesions treated with excision and fulguration were included. Recurrence of anal lesions, progression of disease, and progression to cancer were measured. Ninety-one patients met inclusion criteria. The mean age was 41.6 years, and mean follow-up was 38.6 months (range, 11.0-106.0 mo). On initial pathology, 8 patients (8.8%) had a diagnosis of condyloma acuminatum without dysplasia, 20 patients (22%) had anal intraepithelial neoplasia I, 32 (35.2%) had anal intraepithelial neoplasia II, and 31 (34.1%) had anal intraepithelial neoplasia III. Sixty-nine patients (75.8%) had repeat procedures. Seven (87.5%) of 8 patients with condyloma and 6 (30%) of 20 patients with anal intraepithelial neoplasia I progressed to high-grade lesions. Five (15.6%) of 32 patients progressed from anal intraepithelial neoplasia II to III, and 2 patients with anal intraepithelial neoplasia III (6.5%) developed squamous cell carcinoma (2.3% for the entire cohort). This was a single institution study. High-resolution anoscopy was not used. All of the HIV-positive patients with condyloma or anal intraepithelial neoplasia, regardless of the presence of dysplasia, should be surveyed at equivalent 3-month time intervals, because their risk of progression of disease is high. Video Abstract at http://links.lww.com/DCR/A389.

  10. Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial

    DEFF Research Database (Denmark)

    Dillner, Joakim; Kjaer, Susanne K; Wheeler, Cosette M;

    2010-01-01

    To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata)....

  11. Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration Quantificação de ferritina no líquido cefalorraquidiano como biomarcador para o diagnóstico de infiltração maligna no SNC

    Directory of Open Access Journals (Sweden)

    Sérgio Monteiro de Almeida

    2008-01-01

    Full Text Available Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13; malignant cells not present (n26; inflammatory neurological diseases (n16; neurocysticercosis (n20; acute bacterial meningitis (n18. CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean±SD in the group with neoplasic cells in the CSF was 42.8±49.7 ng /mL, higher than in the other groups (pDiversos marcadores foram estudados com a finalidade de avaliar sua capacidade de diagnosticar a infiltração neoplásica no SNC precocemente e de forma mais precisa. Estudos anteriores mostraram que as concentrações de ferritina no LCR eram mais elevadas nos pacientes com infiltração neoplásica no SNC. O objetivo foi determinar a importância da ferritina no LCR como biomarcador para o diagnóstico de infiltração neoplásica no SNC. Este estudo é baseado em 93 amostras do LCR, divididas em cinco grupos: células malignas presentes (n13; células malignas ausentes (n26; doenças neurologicas inflamatórias (n16; neurocisticercose (n20; meningites bacterianas agudas (n18. Os valores de ferritina no LCR foram determinados por ELISA de microparticulas. O nível de ferritina no LCR (média±desvio padrão no grupo com células neoplásicas no LCR foi 42,8±49,7 ng/mL, mais elevado do que nos outros grupos (p<0.0001. Concluímos que a ferritina no LCR com cut off de 20 ng/mL pode ser um biomarcador para o diagnóstico de infiltração maligna no SNC.

  12. en las relaciones entrenadas

    Directory of Open Access Journals (Sweden)

    Camilo Hurtado P.

    2005-01-01

    Full Text Available El presente estudio exploró los efectos en la adquisición y transferencia de discriminaciones condicionales debidos a las diferentes combinaciones de relaciones entrenadas (identidad-diferencia-semejanza en una tarea de igualación a la muestra de segundo orden. De manera complementaria, fueron además dispuestas en la tarea las características que en estudios relacionados habían sido reportadas como facilitadoras de ejecuciones efectivas, a saber: el uso de instrucciones inespecíficas, arreglos de estímulo de tres formas y dos colores y el entrenamiento concurrente de las relaciones. Ocho sujetos fueron distribuidos en cuatro grupos que variaron en la combinación de relaciones a entrenar. Los resultados mostraron que gran parte de los sujetos cumplieron con el criterio de efectividad en entrenamiento y en transferencia extramodal y extrarrelacional, siendo la relación de identidad la relación en la cual se presentaron ejecuciones perfectas, al margen de si ésta había sido entrenada o no. Se discuten los resultados en términos de velocidad de ajuste a las relaciones y de las configuraciones de la tarea que facilitaron mejores desempeños. Se proponen, además, posibles investigaciones que superen las limitaciones metodológicas encontradas en este estudio y que exploren posibles interacciones de las variables manipuladas con otras variables de interés.

  13. Las neurosis actuales y las psicosis ordinarias

    OpenAIRE

    Aguirre, Javier

    2013-01-01

    El trabajo tiene por finalidad poner en tensión las categorías de psicosis ordinaria y neurosis actuales. En primer lugar, se procede a examinar ambas categorías para luego establecer sus puntos de coincidencia y disidencia. Se concluye que la categoría de neurosis actual propuesta por Freud, es una posible expresión de lo que en la actualidad se llama psicosis ordinaria.

  14. ANATOMÍA PATOLÓGICA Y TUMORES HEREDITARIOS

    Directory of Open Access Journals (Sweden)

    Dra. M. Teresa Vial

    2017-07-01

    Nos referiremos desde el punto de vista patológico a algunas de las neoplasias malignas incluidas en síndromes de cáncer hereditario causados por los principales y más frecuentes genes de predisposición genética. Cáncer de Mama (BRCA1/2, Cáncer Colorectal no Polipósico/Síndrome de Lynch (MMR, Cáncer Gástrico Hereditario, Poliposis adenomatosa familiar (PAF, Cáncer Renal y Síndrome de von Hippel Lindau (VHL y Cáncer Medular de Tiroides (RET.

  15. Carcinoma de células escamosas de cavidad bucal en un centro de tercer nivel de atención social en la ciudad de México: Experiencia de cinco años Oral cavity squamous cells carcinoma, 5 years experience in a third level social assistence center, in Mexico city

    OpenAIRE

    G. Meza García; J.J. Muñoz Ibarra; C. Páez Valencia; B. Cruz Legorreta; B. Aldape Barrios

    2009-01-01

    El carcinoma epidermoide o de células escamosas, es una neoplasia maligna que se origina de las células escamosas del epitelio que recubre la mucosa, es la más frecuente de la cavidad bucal. Objetivo: determinar si la supervivencia y muerte de los pacientes con carcinoma epidermoide de cavidad bucal, asociada a la edad, género, factores de riesgo, grado histológico y tratamiento recibido. Método: Se revisaron los archivos del servicio de Anatomía Patológica del Centro Médico Nacional "20 de N...

  16. Características epidemiológicas y clínicas del cáncer colorrectal en pacientes de la ciudad de Cartagena de Indias durante el periodo 2005 – 2010

    OpenAIRE

    Contreras -Borrego Eusebio Enrique; Benedetti -Padrón Inés; Barrios -García Lía; Alvis -Estrada Luis

    2011-01-01

    INTRODUCCION: el cáncer colorrectal (CCR) es una de las neoplasias malignas más comunes a nivel mundial con 1.234.000 nuevos casosreportados durante el 2008. En Colombia el CCR tiene una frecuencia estimada de 3622 casos/año y una tasa estimada de mortalidad de 2043casos/año (55,8%). El comportamiento epidemiológico de la enfermedad en Cartagena de Indias ha sido descrito únicamente durante el año2003 con 87 nuevos casos, siendo este el tercer cáncer más común en hombres y el cuarto en mujere...

  17. Puerperio y lactancia materna en mujeres con cáncer de mama o mastectomizadas

    OpenAIRE

    Casado Segovia, Miriam

    2016-01-01

    La neoplasia maligna de mama es la más prevalente en las mujeres, siendo la media de edad de 35 años, lo cual refleja que continúan en edad fértil. Por ello explicaremos el proceso de la gestación, y lo interrelacionaremos con la posibilidad de lograr un embarazo, el pronóstico del mismo y su evolución posterior, el puerperio. Debido a que actualmente está demostrado que la mejor alimentación para los recién nacidos es la lactancia materna, hemos decido interrelacionar la lactancia ma...

  18. Induced transdifferentiation of human B-leukemia/lymphoma cell lines and inhibition of leukemogenicity

    OpenAIRE

    2013-01-01

    Las neoplasias malignas de células B abarcan una amplia variedad de enfermedades diferentes, incluyendo el linfoma no Hodgkin (LNH) y leucemia. Actualmente, la quimioterapia, la radiación y el tratamiento con anticuerpos anti-CD20 son los pilares de la terapia contra el linfoma y la leucemia de células B. Sin embargo, el hecho de que un gran porcentaje de pacientes no se cura con estos tratamientos, justifica la búsqueda de nuevas terapias más eficaces. Aunque la inducció...

  19. Las Leyes de Newton

    OpenAIRE

    González S., Fabio

    2015-01-01

    La labor de Newton en el campo de la física, una de las piedras angulares en que se fundamenta esta ciencia, se caracteriza por el hecho de que a partir de unos enunciados básicos explica los diversos fenómenos que estudia la mecánica. Entre las grandes contribuciones de Newton se pueden citar: el descubrimiento de la ley de la gravitación universal, el enunciado de las leyes del movimiento, el teorema del binomio, la formulación básica del cálculo diferencial e integral, así-como algunos tra...

  20. Historia de las series

    OpenAIRE

    Cascajosa Virino, Concepción

    2017-01-01

    Reseña: Historia de las series de Toni de la Torre: la gran impostura Durante mucho tiempo los profesores de cine en España se han quejado (amargamente y en privado) de la recurrencia en la bibliografía de los trabajos de sus estudiantes de los libros de un autor conocido por la escasa calidad de sus textos, cuyos vistosos títulos garantizan que acaben en las estanterías de las bibliotecas universitarias. Es muy propio de la cultura española hacer duras aseveraciones en foros irrelevantes y, ...

  1. Las drogas en Galicia

    OpenAIRE

    Bermejo Barrera, Ana María

    2012-01-01

    Las drogas de abuso han sido consumidas desde los tiempos más remotos, siendo en aquel enton­ ces su uso muy restringido, por la poca disponibilidad de las mismas, a rituales místico-religiosos y a tratamiento de algunas enfermedades. Con la revolución industrial en el siglo XIX, los labora­ torios farmacéuticos extraen los principios activos de las plantas y sintetizan sus derivados, pasan­ do a ser consumidas en mayor escala. La década de los sesenta fue marcada por el aum...

  2. Disease and treatment factors associated with lower quality of life scores in adults with multiple endocrine neoplasia type I.

    Science.gov (United States)

    Goswami, Sneha; Peipert, Benjamin J; Helenowski, Irene; Yount, Susan E; Sturgeon, Cord

    2017-09-14

    Physical and psychosocial morbidity of multiple endocrine neoplasia type-1 is ill-defined. How disease and treatment-related factors relate to patient-reported outcomes including health-related quality of life is unknown. We hypothesized that disease and treatment burden negatively impacts health-related quality of life in adults with multiple endocrine neoplasia type-1. Adults (≥18 years) with multiple endocrine neoplasia type-1 completed an online survey of demographics, disease features, treatments, and Patient-Reported Outcomes Measurement Information System 29-item profile measure, and scores were compared with normative US data. Multivariable modeling was performed to evaluate factors associated with decreased health-related quality of life. Multiple endocrine neoplasia type-1 patients (n = 207) reported worse health-related quality of life compared with US normative data in all health-related quality of life domains (P 50 miles for doctor appointments and ≥20 doctor appointments/year (P < .05) were associated with worse health-related quality of life. History of pancreatic neuroendocrine tumors was not associated with worse health-related quality of life. This is the largest study to assess clinical and treatment factors associated with health-related quality of life in multiple endocrine neoplasia type-1. Persistent hyperparathyroidism, increased travel distance and frequency of doctor appointments were all associated with worse health-related quality of life. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Las innovaciones en las telecomunicaciones y las nuevas identidades laborales

    Directory of Open Access Journals (Sweden)

    Natalia Aruguete

    2006-12-01

    Full Text Available Este trabajo se propone analizar las modificaciones en la política laboral en el sector de telecomunicaciones haciendo eje en la visión que los trabajadores tienen de ella. De esta manera se intenta contestar a la casi nula o distorsionada cobertura mediática que mereció la problemática de la gestión de la fuerza de trabajo durante el proceso de reestructuración que atravesó el sector. El estudio se basa en la información estadística y en entrevistas en profundidad realizadas a los trabajadores de las empresas de telefonía fija que operan en la Argentina. La vivencia que perdura en los trabajadores – despedidos o no – es que la privatización implicó desestabilizar y fragmentar un modo de vida estructurado a partir de la identidad y cultura laborales. Esa pérdida de sentido de una ética en la que el trabajo es sinónimo de realización personal fue vivida por los trabajadores como humillación y falta de respeto a sus trayectorias laborales y profesionales, una desvalorización de su saber, una falta de reconocimiento personal y social a su trabajo y una persistencia en la incertidumbre acerca del futuro.

  4. A new insight into fecal hemoglobin concentration-dependent predictor for colorectal neoplasia.

    Science.gov (United States)

    Yen, Amy Ming-Fang; Chen, Sam Li-Sheng; Chiu, Sherry Yueh-Hsia; Fann, Jean Ching-Yuan; Wang, Po-En; Lin, Sheng-Che; Chen, Yao-Der; Liao, Chao-Sheng; Yeh, Yen-Po; Lee, Yi-Chia; Chiu, Han-Mo; Chen, Hsiu-Hsi

    2014-09-01

    We sought to assess how much of the variation in incidence of colorectal neoplasia is explained by baseline fecal hemoglobin concentration (FHbC) and also to assess the additional predictive value of conventional risk factors. We enrolled subjects aged 40 years and over who attended screening for colorectal cancer with the fecal immunochemical test (FIT) in Keelung community-based integrated screening program. The accelerated failure time model was used to train the clinical weights of covariates in the prediction model. Datasets from two external communities were used for external validation. The area under curve (AUC) for the model containing only FHbC was 83.0% (95% CI: 81.5-84.4%), which was considerably greater than the one containing only conventional risk factors (65.8%, 95% CI: 64.2-67.4%). Adding conventional risk factors did not make significant additional contribution (p = 0.62, AUC = 83.5%, 95% CI: 82.1-84.9%) to the predictive model with FHbC only. Males showed a stronger linear dose-response relationship than females, yielding gender-specific FHbC predictive models. External validation confirms these results. The high predictive ability supported by a dose-dependent relationship between baseline FHbC and the risk of developing colorectal neoplasia suggests that FHbC may be useful for identifying cases requiring closer postdiagnosis clinical surveillance as well as being an early indicator of colorectal neoplasia risk in the general population. Our findings may also make contribution to the development of the FHbC-guided screening policy but its pros and cons in connection with cost and effectiveness of screening should be evaluated before it can be applied to population-based screening for colorectal cancer.

  5. The Analysis of Genetic Polymorphism. The Relationship between Interleukin – 4 Polymorphisms and Intraepithelial Cervical Neoplasia

    Directory of Open Access Journals (Sweden)

    Florin STAMATIAN

    2010-09-01

    Full Text Available Objectives: Interleukin 4 plays a critical role in T helper 2 responses to HPV infection and angiogenesis. The present study aim to study the association between the IL4 promoter polymorphism – 590 C>T, respectively VNTR intron 2 polymorphism and cervical intraepithelial neoplasia. Material and method: We have realized a prospective case controls study that included 128 cases of intraepithelial neoplasia positive for HPV HR testing and 111 controls negative for intraepithelial lesion and also negative for HPV HR. Clinical examination was performed on each patient; blood and cervical sample were obtained. Cervical probes were analyzed regarding cytology and HPV HR testing. From peripheral blood DNA sample was obtain followed by genotype analysis for IL4 -590 C>T using PCR RFLP, respectively IL4 70 bp VNTR determined by PCR. Results: The absolute frequency of genotypes for IL4 -590 C>T was T/T-5, C/T-42, C/C-81 in the cases group respectively T/T-2, C/T-32, C/C-77 in the control group. The chi-square test had a value of 0.983 (p=0.321 while considering the presence of a minimum one single variant allele as a risk factor for cervical cancer, respectively 0.926 (p=0.336 for homozygous variant genotype. Odds ratio was 0.761 (95%CI [0.443-1.306] while considering C/T+T/T respectively 2R/3R, 2R/2R as a risk factor, and 0.451 (95%CI 95% [0.086-2.374] - TT respectively 2R/2R as a risk factor. Conclusion: No linear statistical significant association has been found between IL4 polymorphism and cervical neoplasia (p = 0.322.

  6. A profile of cases of gestational trophoblastic neoplasia at a large tertiary centre in dubai.

    Science.gov (United States)

    Rangwala, Tasneem H; Badawi, Faiza

    2011-01-01

    Objectives. To study (1) the prevalence of different types of gestational trophoblastic neoplasia (GTN) in the local and nonlocal population of women at Al Wasl Hospital, a tertiary level referral centre for northern Emirates, (2) the safety of cervical preparation before uterine evacuation, (3) the role of repeat uterine evacuation in curing these cases, and (4) the percentage of cases ultimately requiring chemotherapy. Material and Methods. Retrospective analysis of case records of 35 women with diagnosis of gestational trophoblastic neoplasia were managed in the Department of Obstetrics and Gynecology at Al Wasl Hospital, over a 2-year period between January 2007 to December 2008. Results. 35 cases of gestational trophoblastic neoplasia were seen in a 2-year period (January 2007 to December 2008) at Al Wasl Hospital, with 7000 deliveries per year, prevalence being 1 in 400 live births. 60% cases were local Arabs. Histopathology revealed complete mole in 13 cases, partial mole in 17 cases, hydropic degeneration of villi in 4 cases, and no identifiable tissue in 1 case. No cases of choriocarcinoma or placental site trophoblastic tumour were seen during the study period. 34% cases received cervical preparation with prostaglandins prior to surgical curettage. Complications were minor. 62% were cured by primary suction curettage, 12% after second (repeat) uterine evacuation, and 25% needed single drug chemotherapy. 8% cases defaulted after primary evacuation and were lost to followup. Conclusions. Prevalence of GTN in the local Arab population is similar to other Asian populations. The majority of cases are cured by simple suction uterine curettage. Cervical preparation with prostaglandins should be done in selected cases to avoid perforation during evacuation. Second (repeat) uterine evacuation can be curative in some cases with strict selection criteria and avoid the need for chemotherapy. Regional registry of cases is needed to estimate the true incidence of this

  7. The role of apparent diffusion coefficient values in detecting testicular intraepithelial neoplasia: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Tsili, Athina C., E-mail: a_tsili@yahoo.gr [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Ntorkou, Alexandra, E-mail: alexdorkou@yahoo.com [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Baltogiannis, Dimitrios, E-mail: Greece.dbaltog@cc.uoi.gr [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Goussia, Anna, E-mail: agoussia@uoi.gr [Department of Pathology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Astrakas, Loukas G., E-mail: astrakas@uoi.gr [Department of Medical Physics, Medical School, University of Ioannina, 45110 Ioannina (Greece); Malamou-Mitsi, Vasiliki, E-mail: vmalamou@cc.uoi.gr [Department of Pathology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Sofikitis, Nikolaos, E-mail: akrosnin@hotmail.com [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Argyropoulou, Maria I., E-mail: margyrop@cc.uoi.gr [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece)

    2015-05-15

    Highlights: • ADC values proved useful in the discrimination between TGCNs and normal testis. • Testicular intraepithelial neoplasia represents the precursor of most TGCNs. • ADC values cannot be used to detect testicular intraepithelial neoplasia. - Abstract: Introduction: The aim of this study is to improve detection of testicular intraepithelial neoplasia (TIN) by measurement of apparent diffusion coefficient (ADC) values. Materials and methods: Fifty-six MRI examinations of the scrotum, including 26 histologically proven testicular germ cell neoplasms were retrospectively evaluated. DWI was performed using a single shot, multi-slice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s mm{sup −2}. ADC measurements were classified into three groups according to their location: group 1 (n = 19), non-tumoral part, adjacent to testicular carcinoma, where the possible location of TIN was; group 2 (n = 26), testicular carcinoma; and group 3 (n = 60), normal testicular parenchyma. Analysis of variance (ANOVA) followed by post hoc analysis (Dunnett T3) was used for statistical purposes. Results: The mean ± s.d. of ADC values (×10{sup −3} mm{sup 2}/s) of different groups were: group 1, 1.08 ± 0.20; group 2, 0.72 ± 0.27; and group 3, 1.11 ± 0.14. ANOVA revealed differences of mean ADC between groups (F = 38.859, P < 0.001). Post hoc analysis showed differences between groups 2 and 3 (P < 0.001), groups 2 and 1 (P < 0.001), but not between groups 3 and 1 (P = 0.87). Conclusions: Based on our preliminary results, ADC values do not provide a reliable differentiation between TIN and testicular carcinoma or normal testicular parenchyma.

  8. The ISUP system of staging, grading and classification of renal cell neoplasia

    Directory of Open Access Journals (Sweden)

    Hemamali Samaratunga

    2014-07-01

    Full Text Available There have been significant changes in the staging, classification and grading of renal cell neoplasia in recent times. Major changes have occurred in our understanding of extra-renal extension by renal cell cancer and how gross specimens must be handled to optimally display extra-renal spread. Since the 1981 World Health Organization (WHO classification of renal tumors, in which only a handful of different entities were reported, many new morphological types have been described in the literature, resulting in 50 different entities reported in the 2004 WHO classification. Since 2004, further new entities have been recognized and reported necessitating an update of the renal tumor classification. There have also been numerous grading systems for renal cell carcinoma with Fuhrman grading, the most widely used system. In recent times, the prognostic value and the applicability of the Fuhrman grading system in practice has been shown to be, at best, suboptimal. To address these issues and to recommend reporting guidelines, the International Society of Urological Pathology (ISUP undertook a review of adult renal neoplasia through an international consensus conference in Vancouver in 2012. The conduct of the conference was based upon evidence from the literature and the current practice amongst recognized experts in the field. Working groups selected to deal with key topics evaluated current data and identified points of controversy. A pre-meeting survey of the ISUP membership was followed by the consensus conference at which a formal ballot was taken on each key issue. A 65% majority vote was taken as consensus. This review summarizes the outcome and recommendations of this conference with regards to staging, classification and grading of renal cell neoplasia.

  9. The ISUP system of staging, grading and classification of renal cell neoplasia.

    Science.gov (United States)

    Samaratunga, Hemamali; Gianduzzo, Troy; Delahunt, Brett

    2014-01-01

    There have been significant changes in the staging, classification and grading of renal cell neoplasia in recent times. Major changes have occurred in our understanding of extra-renal extension by renal cell cancer and how gross specimens must be handled to optimally display extra-renal spread. Since the 1981 World Health Organization (WHO) classification of renal tumors, in which only a handful of different entities were reported, many new morphological types have been described in the literature, resulting in 50 different entities reported in the 2004 WHO classification. Since 2004, further new entities have been recognized and reported necessitating an update of the renal tumor classification. There have also been numerous grading systems for renal cell carcinoma with Fuhrman grading, the most widely used system. In recent times, the prognostic value and the applicability of the Fuhrman grading system in practice has been shown to be, at best, suboptimal. To address these issues and to recommend reporting guidelines, the International Society of Urological Pathology (ISUP) undertook a review of adult renal neoplasia through an international consensus conference in Vancouver in 2012. The conduct of the conference was based upon evidence from the literature and the current practice amongst recognized experts in the field. Working groups selected to deal with key topics evaluated current data and identified points of controversy. A pre-meeting survey of the ISUP membership was followed by the consensus conference at which a formal ballot was taken on each key issue. A 65% majority vote was taken as consensus. This review summarizes the outcome and recommendations of this conference with regards to staging, classification and grading of renal cell neoplasia.

  10. Clinical value of multiband mucosectomy for the treatment of squamous intraepithelial neoplasia of the esophagus.

    Science.gov (United States)

    Jin, Xi-Feng; Sun, Qing-Yan; Chai, Tong-Hai; Li, Shu-hui; Guo, Yan-li

    2013-04-01

    To evaluate the clinical value of multiband mucosectomy (MBM) for the treatment of squamous intraepithelial neoplasia of the esophagus. A total of 51 lesions located at esophagus from 43 patients were treated with MBM, among which 11 were diagnosed as middle-grade intraepithelial neoplasia, 25 as high-grade intraepithelial neoplasia, and 15 as early esophageal cancer pathologically. Primary end-points were the rate of complete endoscopic resection and the mean operation time; the second end-points were the postoperative local recurrence rate and acute plus early complications. The histopathological results were compared between pre-MBM biopsy and MBM specimens. All patients were followed up endoscopically. A total of 52 MBM procedures with 180 resections were performed in 43 patients. The complete endoscopic resection was achieved in 92.3% (95% confidence interval [CI] 81.8-96.9%). The sizes of the lesions ranged from 10 × 8 mm to 25 × 23 mm. The mean operation time is 37 ± 5 min. The operative acute bleeding complication was 7.6% (95% CI 3-18.1%); no perforations occurred. Early complications consisted of delayed bleeding (one patient 1.9%; 95% CI 0.3-10.1%) and slight esophageal stenosis (one patient). The histopathological diagnosis of 26 cases (51%) was consistent between biopsy and MBM samples, while 20 lesions exhibited higher grade dysplasia. The local recurrence rate was 6.9% (3/43) at 1 year, 9.3% (4/43) at 2 years, and 9.3% at 2.5 years. No death occurred during follow-up. MBM is a safe and effective technique for the treatment of early esophageal cancer and precancerous lesions. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  11. las relaciones interpersonales

    Directory of Open Access Journals (Sweden)

    Juan Gabriel Gómez Albarello

    2011-01-01

    Full Text Available En este ensayo discuto el efecto que han tenido las filtraciones realizadas por WikiLeaks en las relaciones internacionales y en las relaciones interpersonales. Sostengo que Wikileaks motivará a muchos a continuar con la práctica de tales filtraciones y que esa motivación proviene de la justificación de esa práctica en dos conjuntos de valores: la ética del hacker y los valores democráticos. También afirmo que el efecto de esas filtraciones puede causar un impacto profundo en la esfera de la cultura puesto que la evaluación de la conducta de los estadistas se realiza usualmente mediante de analogías basadas en la experiencia interpersonal. Luego de presentar argumentos en favor de decir la verdad en las relaciones personales, concluyo destacando la forma como se engranan varios tipos de argumentos.

  12. Aviso para las viudas.

    Directory of Open Access Journals (Sweden)

    Francisco de Sales

    2000-01-01

    Full Text Available San Pablo instruye todos los prelados en la persona de su Timoteo, diciendo: «Honra las viudas que son verdaderamente viudas». Para ser, pues, verdaderamente viuda, son necesarias estas cosas

  13. y las comunicaciones

    Directory of Open Access Journals (Sweden)

    Lucio Fuentelsaz

    2005-01-01

    Full Text Available Las Tecnologías de la Información y las Comunicaciones (TIC están en todas partes incluso en las estadísticas de productividad. Esta afirmación, a modo de antítesis de la proposición formulada por el premio Nobel Robert Solow, constituye el punto de partida de este trabajo que se enmarca dentro de una corriente de investigación que ha sido objeto de abundantes estudios en los últimos años y cuyo propósito fundamental es analizar los determinantes de la relación entre la inversión en TIC y las mejoras en la productividad empresarial.

  14. Las Serpientes en Colombia

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    Daniel H.

    1949-12-01

    Full Text Available El estudio de las serpientes en Colombia no deja de tener su particular interés; existe una inmensa variedad de especies que se escalonan desde los valles ardientes hasta alturas relativamente considerables; en estos últimos puntos disminuye notablemente la variedad de formas y de modo especial las especies provistas de veneno. Hacer una distinción entre las especies venenosas y las inofensivas, resulta un tanto difícil; en algunos textos se dan unas cuántas reglas, pero la mayor parte de ellas sólo tienen aplicación con especies exóticas ya que la mayor parte de esas distinciones se han tomado de obras que hacen referencia a la fauna europea.

  15. Las vitrinas del museo

    OpenAIRE

    2010-01-01

    Tanto las obras de arte como los animales nos ocultan información cuando se reúnen en un museo, pues quedan al margen del contexto espacial y temporal del que proceden. No obstante, el ojo avezado sabrá interpretar una parte de esa historia perdida. Del mismo modo, algunas especies vivas traslocadas conservan rasgos que nos ayudan a inferir las condiciones ambientales de su lugar de origen.

  16. Las vacas imitadores expertos

    OpenAIRE

    Chevalier, Pedro

    2009-01-01

    La mayoría de las especies del género Hypoplectrus presentan un comportamiento conocido como mimetismo agresivo. Este fenómeno consiste en la imitación de los patrones de coloración, por parte de las vacas, de peces que no son depredadores de crustáceos y pequeños peces. Al imitar el color de peces inofensivos pueden acercarse a sus presas sin que estas huyan.

  17. Risk of head-and-neck cancer following a diagnosis of severe cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Svahn, Malene F; Munk, C; Jensen, S M

    2016-01-01

    OBJECTIVE: Women with a history of cervical intraepithelial neoplasia grade 3 including adenocarcinoma in situ (CIN3/AIS) may be more prone to develop cancers of the ano-genital region and head-and-neck cancers. The current literature is, however, limited. METHODS: We established a nationwide...... cohort of approximately 2,500,000 Danish women born in 1918-1990. By linking the cohort to population-based health registries, we obtained information on CIN3/AIS, cancer, migration, death, education, and smoking. Cox proportional hazards models were used to estimate hazard ratios (HRs) and confidence...

  18. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

    Energy Technology Data Exchange (ETDEWEB)

    Luongo, C.; Gould, K.A.; Moser, A.R. (Univ. of Wisconsin, Madison (United States)); Su, Likuo; Kinzler, K.W.; Vogelstein, B. (Johns Hopkins Oncology Center, Baltimore, MD (United States)); Dietrich, W.; Lander, E.S. (MIT, Cambridge (United States))

    1993-01-01

    The Min (multiple intestinal neoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for the Min mutation. Min, a mutant allele of Apc, the mouse homo- log of the human APC (adenomatous polyposis coli) gene, maps to proximal chromosome 18. The synteny between Apc and Mcc, the mouse homolog of the human MCC (mutated in colorectal cancer) gene, is conserved between mouse and human, although the gene order in the Apc to Mcc interval is different from that in the APC to MCC interval. 29 refs., 3 figs.

  19. Radiation-induced intestinal neoplasia in a genetically-predisposed mouse (Min)

    Energy Technology Data Exchange (ETDEWEB)

    Ellender, M.; Larder, S.M.; Harrison, J.D.; Cox, R.; Silver, A.R.J. [National Radiological Protection Board, Chilton (United Kingdom)

    1997-03-01

    A mouse lineage with inherited predisposition to multiple intestinal neoplasia (min) has been proposed as a model to study human colorectal cancer. Min mice are heterozygous for the adenomatous polyposis coli (Apc) gene implicated in human familial adenomatous polyposis (FAP). There is an increased risk of intestinal cancer in humans following radiation exposure and the min mouse model may be used to further our understanding of the molecular mechanisms involved. The present study showed a 2 Gy dose of x-rays doubles the tumour numbers in the murine gastrointestinal tract of F1 min heterozygotes. The distribution of tumours through the gut was also recorded. (authors)

  20. Nonfunctional Metastatic Parathyroid Carcinoma in the Setting of Multiple Endocrine Neoplasia Type 2A Syndrome

    Directory of Open Access Journals (Sweden)

    María Posada-González

    2014-01-01

    Full Text Available Parathyroid carcinoma is a very rare malignancy. It has been associated with hyperparathyroidism-jaw tumour syndrome, familial isolated primary hyperparathyroidism, and multiple endocrine neoplasia type 1 (MEN-1 and 2A (MEN-2A syndromes. We report a 54-year-old man with a MEN-2A which presents with a nonfunctional metastatic parathyroid carcinoma and a pheochromocytoma in the absence of medullary thyroid carcinoma. Only a few cases of parathyroid carcinoma have been reported in the literature associated with this syndrome.