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Sample records for lamcchia sallustro daniela

  1. Recensione a Daniela Marcheschi, "Il sogno della letteratura. Luoghi, maestri, tradizioni"

    Directory of Open Access Journals (Sweden)

    Pina Paone

    2013-06-01

    Full Text Available Recensiamo la raccolta di saggi Il sogno della letteratura. Luoghi, maestri, tradizioni di Daniela Marcheschi, Gaffi editore, Roma, 2012. Il libro si presenta come una riflessione sul senso profondo della letteratura e dell’attività critica e si pone come scopo di esaminare la situazione attuale della cultura per riedificare e ricostruire, attraverso il vaglio critico delle tradizioni, l’abbandono di clichés teorici e narrativi e il recupero di un’idea forte della letteratura in virtù di un autentico e rinnovato slancio etico che restituisca verità alla parola.

  2. Tandem Paul ja Anne Daniela Rodgers, Kaunase modernistid ja arenev Meiu Münt / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2006-01-01

    Kuni 23. IV Tartu Kunstimuuseumis avatud Paul ja Anne Daniela Rodgersi näitusest. 15. II-13. III Tartu kaheksas galeriis avatud Kaunase kunstnike näitusest, Arvidas Zhalpyse installatsioonist "Kõik toolist" ja Agne Jonkute maalist "Olematuse faktid" Tartu Kunstimajas. Kuni 25. III G-galeriis avatud Meiu Mündi näitusest "Päev on pime"

  3. Tandem Paul ja Anne Daniela Rodgers, Kaunase modernistid ja arenev Meiu Münt / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2006-01-01

    Kuni 23. IV Tartu Kunstimuuseumis avatud Paul ja Anne Daniela Rodgersi näitusest. 15. II-13. III Tartu kaheksas galeriis avatud Kaunase kunstnike näitusest, Arvidas Zhalpyse installatsioonist "Kõik toolist" ja Agne Jonkute maalist "Olematuse faktid" Tartu Kunstimajas. Kuni 25. III G-galeriis avatud Meiu Mündi näitusest "Päev on pime"

  4. O canto da laicidade: Daniela Mercury e o debate sobre casamento civil igualitário no Brasil

    Directory of Open Access Journals (Sweden)

    Rafael da Silva Noleto

    Full Text Available Resumo A performance pública da cantora Daniela Mercury ao assumir (em 2013 um relacionamento conjugal com outra mulher é tomada como ponto de partida para a discussão sobre moralidades religiosas no contexto de debates acerca do casamento civil igualitário no Brasil contemporâneo. Pretende-se abordar a conflituosa inserção de moralidades religiosas em certos debates públicos sobre direitos, destacando a noção de “subjetivismo” como um valor estruturante da modernidade na produção de sujeitos autônomos em meio a diversas formações religiosas. O debate aqui contido também almeja destacar as tensões entre a formação católica de Daniela Mercury e seu pertencimento atual ao candomblé, problematizando questões sobre homoparentalidade à luz dos valores religiosos professados pela cantora.

  5. “Resistance to Change—A New Perspective: A Textbook for Managers Who Plan to Implement a Change” by Daniela Bradutanu

    OpenAIRE

    James W. Barnes

    2015-01-01

    hange is inevitable—it’s in our experience wherever we turn. One area, however, where most people do not want to experience change is in the work place. Whether the change is beneficial or not, those who are subjected to a change in the workplace will almost without fail resist a change to their status quo. Managers have normally come to accept this and just plough ahead, coercing their subordinates into accepting the change. With the advent of Dr Daniela Bradutanu’s new book “Resistance to C...

  6. “Resistance to Change—A New Perspective: A Textbook for Managers Who Plan to Implement a Change” by Daniela Bradutanu

    Directory of Open Access Journals (Sweden)

    James W. Barnes

    2015-12-01

    Full Text Available hange is inevitable—it’s in our experience wherever we turn. One area, however, where most people do not want to experience change is in the work place. Whether the change is beneficial or not, those who are subjected to a change in the workplace will almost without fail resist a change to their status quo. Managers have normally come to accept this and just plough ahead, coercing their subordinates into accepting the change. With the advent of Dr Daniela Bradutanu’s new book “Resistance to Change”, there is another way—a way of cooperation between managers and employees.

  7. “Resistance to Change—A New Perspective: A Textbook for Managers Who Plan to Implement a Change” by Daniela Bradutanu

    OpenAIRE

    James W. Barnes

    2015-01-01

    hange is inevitable—it’s in our experience wherever we turn. One area, however, where most people do not want to experience change is in the work place. Whether the change is beneficial or not, those who are subjected to a change in the workplace will almost without fail resist a change to their status quo. Managers have normally come to accept this and just plough ahead, coercing their subordinates into accepting the change. With the advent of Dr Daniela Bradutanu’s new book “Resistance to C...

  8. «Lo personal es político»: Patrones de construcción de género en la Transición española. "Daniela Astor y la caja negra", de Marta Sanz

    OpenAIRE

    Somolinos Molina, Cristina

    2015-01-01

    En el marco de los denominados «nuevos realismos», Daniela Astor y la caja negra aborda la particular manera por la que las mujeres hubieron de enfrentarse a las contradicciones del periodo de la transición a la democracia en España. El análisis de la construcción de la identidad de género en el ámbito de lo personal y la transformación de esta identidad individual en conciencia política en la novela permite establecer relaciones entre las dinámicas de la sociedad española de 1978 en cuanto a...

  9. Der justizielle Pluralismus der europäischen Verfassungsgemeinschaft: „babylonische Gerichte” oder „Gerichte für Babylon”? / Maria Daniela Poli

    Index Scriptorium Estoniae

    Poli, Maria Daniela

    2016-01-01

    Dialoogi võimalikkusest ja koostööst Euroopa Kohtu, Euroopa Inimõiguste Kohtu ja liikmesriikide kohtute vahel euroopa ühtse menetlusõiguse puudumise ja konkureeriva õigusemõistmise tingimustes

  10. Znaczenie intencji dla moralnej oceny czynu - stanowisko Daniela Wegnera (THE MEANING OF INTENTION FOR MORAL EVALUATION OF AN ACTION - DANIEL WEGNER VIEW

    Directory of Open Access Journals (Sweden)

    Marcin Cichosz

    2008-12-01

    Full Text Available In the article, the author attempts to compare and confront Daniel Wegner's idea of a conscious will with the selected ethic doctrines in the context of relationship between intention and the moral evaluation of an action. According to the utilitarian doctrine, when one evaluates an action intention should not be considered because only the results of an action are relevant. On the other hand, Kant and the ethics of love for fellowmen claim that intention is a direct cause of action, therefore, it is intention that should really be evaluated. On the basis of Wegner's model of a conscious will, one may state that an utilitarian attitude is more justified in many causes. In the act of volition, intention serves only as a commentary, rather than as a cause (as it is commonly believed. In Wegner's opinion the main role of intention is to explain action in the context of the plans, desires and beliefs of an agent. It is all due to the fact that in social interactions, one should always have the ability to explain one's own behavior: ignorance of the causes of one's behavior is inadmissible in this context (odium of insane action. Moreover, when intention and action match, a specific kind of feeling - phenomenal will - is added to the act of volition. This particular feeling not only strengthens the relationship between intention and action. but it also helps the agent to distinguish his own actions from other actions of other agents. It means that the ultimate form of intention may be completely different from the actual causes of a particular type of behavior.To conclude, due to Wegner's work, the utilitarian doctrine gained strong support for the thesis that intention should not be considered during the moral evaluation of action.

  11. Pojetí městské vlády v díle Politia historica Daniela Adama z Veleslavína

    OpenAIRE

    JANOŠŤÁKOVÁ, Petra

    2011-01-01

    The main objective of this thesis is to publish the fourth book of Politia historica, which was translated in 1584 and published by Daniel Adam of Veleslavín. The work Regentenbuch of the German humanist Georg Lauterbeck, published in 1579, was the original for his work. The name of the fourth book is ?About regiment and administration of municipalities and cities, how they should and could be ordered in the best way? and it should serve as a handbook for city administrators and clerks, how t...

  12. Book Review. Interdisciplinary Approaches in Social Sciences, Editor: Daniela Soitu, Cristina Gavriluta, Antonio Maturo, “Alexandru Ioan Cuza” University Printing House, Iasi, 2013

    Directory of Open Access Journals (Sweden)

    Mihaela Dana IGNAT

    2013-09-01

    Full Text Available Qualitative theories and quantitative models (p.9 represent the subject of discussion of this book, which brings together interdisciplinary perspectives and studies of numerous specialists in fields such as sociology, philosophy, mathematics, political science and communication, medicine, provides the knowledge required to develop strategies and programs implemented at international, national, sectoral and local levels.

  13. Gianfranco Folena, Vocabolario del veneziano di Carlo Goldoni, Redazione a cura di Daniela Sacco e Patrizia Borghesan. Regione del Veneto - Fondazione Giorgio Cini - lstituto di Enciclopedia ltaliana, Venezia 1993; pp. 718.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    1995-12-01

    Full Text Available E' con profonda commozione che mi accingo a stendere una  breve recensione dell' opera postuma che porta il nome di Gianfranco Folena, scomparso prematuro nel 1992. Con l'italianistica di Ljubljana Folena ebbe rapporti amichevoli. A due riprese aveva fatto conferenze molto sentite e ci ha conquistati, oltre che con la sua dettagliata esposizione dei fatti e la perspicace analisi linguistica e filologica (ricordo ancora la conferenza sulla lingua nel Piovano Arlotto, anche con la sua affascinante pronuncia toscana. A me personalmente ha sempre elargito consigli (ebbi con lui un primo incon­ tro nel lontano 1952 a Firenze, lui, allora, assistente di Bruno Migliorini, e l'ultimo, solo telefonico, nel 1991 quando io, novello, incominciavo a produrre. Folena ha reso possibile la pubblicazione nelle riviste linguistiche italiane dei miei primi scritti e gliene sono sinceramente grato.

  14. Radical Polymerization of Vinyl Acetate and Methyl Methacrylate Using Organochromium Initiators Complexed with Macrocyclic Polyamines

    Science.gov (United States)

    1994-06-30

    METHYL METHACRYLATE USING ORGANOCHROMIUM REA NTS COMPLEXED WITH MACROCYCLIC A• by Daniela Mardare, Scott Gaynor, Krzysztof Matyjaszewski DTIC Published... Daniela Mardare, Scott Gaynor, Krzysztof Matyjaszewski 7. PERFORMING ORGANIZATION NAME(S) AND ADORESS(ES) a. PERFORMING ORGANIZATION Carnegie Mellon

  15. Seasonality and variability of coccolithophore fluxes in response to diverse oceanographic regimes in the Bay of Bengal: sediment trap results. M.V.S. Gupthaa & b, Lina P. Mergulhaoa,*, Daniela Ungerc and V.S.N. Murtyd a National Institute of Oceanography, Dona Paula, Goa - 403 004, India b 62, Sagar Society, Dona Paula, Goa - 403 004, India c Center for Tropical Marine Ecology, Fahrenheitstrasse 6, D 28359 Bremen, Germany d National Institute of Oceanography, 176, Lawsons Bay Colony, Visakhapatnam - 530 017, India

    Science.gov (United States)

    Medimi, M.

    2011-12-01

    A study on coccolithophores both in shallow and deep sediment trap samples, collected over a period of one year (January 1992 - December 1992) from three trap locations in the Bay of Bengal were used to understand their production and export processes in relation to diverse oceanographic regimes associated with reversing monsoons. A total of 25 species of coccolithophores were identified, which includes some of the important species, Gephyrocapsa oceanica, Umbilicosphaera sibogae, Florisphaera profunda, Umbellosphaera irregularis, Emiliania huxleyi, Oolithotus antillarum, Umbellosphaera tenuis, Helicosphaera carteri and Calcidiscus leptoporus. The total coccolithophore fluxes increased from the northern to southern Bay of Bengal where G. oceanica, U. sibogae¬ and E. huxleyi were dominant species displaying seasonality with peak fluxes occurring during southwest (SW) and northeast (NE) monsoons reflecting their affinity for nutrient-rich waters brought in by river plumes, divergences and cyclonic eddies. U. irregularis, an indicator of oligotrophic/warm water, recorded peak abundance fluxes only during the spring intermonsoon period at all trap locations thus inferring its preference for oligotrophic conditions caused by increased Sea Surface Temperature (SST), stratification and lack of nutrient supply due to weak wind velocities. The deep dwelling species, F. profunda recorded high fluxes during the fall intermonsoon (October/November) in the northern and southern traps and during the spring intermonsoon. The peak fluxes during the spring intermonsoon (April/May) in the central and southern traps indicated the prevalence of a deep nutricline when oligotrophic conditions prevailed at the surface. Interestingly, dissolution was encountered throughout the year evidenced by the presence of corroded coccoliths.

  16. Eramu Viimsis = Private residence in Viimsi

    Index Scriptorium Estoniae

    2011-01-01

    Arhitektide Toomas Tammise ja Kaiko Kivi (Arhitektuuriagentuur) poolt kunstikollektsionäärile projekteeritud eramu sisekujundusest. Sisearhitektid Andres Labi ja Janno Roos (Ruumilabor OÜ). Peegliraamide autor Anne Daniela Rodgers. Loetletud sisearhitektide koos tehtud töid

  17. Eramu Viimsis = Private residence in Viimsi

    Index Scriptorium Estoniae

    2011-01-01

    Arhitektide Toomas Tammise ja Kaiko Kivi (Arhitektuuriagentuur) poolt kunstikollektsionäärile projekteeritud eramu sisekujundusest. Sisearhitektid Andres Labi ja Janno Roos (Ruumilabor OÜ). Peegliraamide autor Anne Daniela Rodgers. Loetletud sisearhitektide koos tehtud töid

  18. Actigraphy of Wrist and Ankle for Measuring Sleep Duration in Altitude Travelers.

    Science.gov (United States)

    Latshang, Tsogyal Daniela; Mueller, Daniela Juliana; Lo Cascio, Christian Maurizio; Stöwhas, Anne-Christin; Stadelmann, Katrin; Tesler, Noemi; Achermann, Peter; Huber, Reto; Kohler, Malcolm; Bloch, Konrad Ernst

    2016-09-01

    Latshang, Tsogyal Daniela, Daniela Juliana Mueller, Christian Maurizio Lo Cascio, Anne-Christin Stöwhas, Katrin Stadelmann, Noemi Tesler, Peter Achermann, Reto Huber, Malcolm Kohler, and Konrad Ernst Bloch. Actigraphy of wrist and ankle for measuring sleep duration in altitude travelers. High Alt Med Biol. 17:194-202, 2016-Aims: Actigraphy might be convenient to assess sleep disturbances in altitude field studies. Therefore, we evaluated whether actigraphy accurately measures sleep duration in healthy subjects traveling to altitude.

  19. A Program of Continuing Research on Representing, Manipulating, and Reasoning about Physical Objects

    Science.gov (United States)

    1991-06-01

    Daniela Rus. 4. The Role of Simulation in Science and Engineering, Opening of the Theory Center, Cornell University, June 4, 1991. John Hopcroft. 5...they call epsilon geometry to rea - son about the amount of perturbation of the input re- V Ztep E *R, 3 x E MODELS(Zrep) quired for certain epsilon

  20. Motion Estimation from Image and Inertial Measurements

    Science.gov (United States)

    2004-11-01

    gross mistracking have been explored, corresponding to 3.0, 6.0, and 9.0 pixel thresholds for the change in error. The 3.0 pixel threshold is the most rea ...Experimental comparison of techniques for lo- calization andmapping using a bearing-only sensor. In Daniela Rus and Sanjiv Singh, editors, Experimental

  1. "Polli päevikud" Saksamaal edukas

    Index Scriptorium Estoniae

    2011-01-01

    Chris Krausi film "Polli päevikud" võitis Saksa Filmiakadeemia filmiauhinna Lola neljas kategoorias: kõrvalosa (Richy Müller), operaatoritöö (Daniela Knapp), kunstnikutöö (Silke Buhr) ja kostüümid (Gioia Raspé)

  2. Year of the Air Force Family: 2009 Survey of Active-Duty Spouses

    Science.gov (United States)

    2011-01-01

    file (Castaneda et al., 2008). For these rea - sons, we did not eliminate anyone from the sample who listed cell phone numbers for home phones...pubs/monographs/MG918/ Lim, Nelson, Daniela Golinelli, and Michelle Cho, “Working Around the Military” Revisited: Spouse Employment in the 2000

  3. Heterogeneous Multi-Robot Cooperation

    Science.gov (United States)

    1994-02-01

    the objects the robots manipulate are hazardous waste. I have not actually applied the robots to reA toxic waste spills, since they are simply small...1993] Bruce Randall Donald, James Jennings, and Daniela Rus. To- wards a theory of information invariants for cooperating autonomous mobile robots

  4. Utilizing Bayesian Techniques for User Interface Intelligence

    Science.gov (United States)

    1996-12-01

    rea - soning and knowledge) have placed little or no emphasis on the expert system user interface. These developers spend most resources perfecting the...1994). 24. Cesta, Amedeo and Daniela DAloisi. "Building Interfaces as Personal Assis- tants," SIGCHI Bulletin, 28(3):108-113 (1996). 25. Chappel, H

  5. "Polli päevikud" sai neli Lolat

    Index Scriptorium Estoniae

    2011-01-01

    Eesti osalusel valminud Saksa film "Polli päevikud" võitis neli Saksa Filmiakadeemia auhinda Lola: kõrvalosa (Richy Müller), operaatoritöö (Daniela Knapp), kunstnikutöö (Silke Buhr) ja kostüümid (Gioia Raspé)

  6. JPRS Report, East Europe

    Science.gov (United States)

    2007-11-02

    Interview with Pawel Szymanski, secretary, Sejm depu- ties trade union group, by Daniela Sielska] [Text] [Question] I will ask a rather blunt...compatriots bring into Poland. A majority of our respondents favor, however, the exist- ence and expansion of dollar stores. Generally the rea - sons

  7. ÁFRICA NEGRA: HISTÓRIA E CIVILIZAÇÕES. TOMO II (DO SÉCULO XIX AOS NOSSOS DIAS)

    OpenAIRE

    Rosemberg Ferracini

    2012-01-01

    M’BOKOLO, Elikia. África Negra: história e civilizações. Tomo II (Do século XIX aos nossos dias). Tradução de Manuel Resende, revisada academicamente por Daniela Moreau, Valdemir Zamparoni e Bruno Pessoti. Salvador: EDUFBA; São Paulo: Casa das Áfricas, 2011, 754 p.

  8. Konrad Mäe medal Laurentsiusele ja A. D.-le

    Index Scriptorium Estoniae

    1999-01-01

    Konrad Mäe medal ja preemia 1999. a. loomingu eest anti 19. XI Rüütelkonna hoones üle maalikunstnik Lauri Sillakule (Laurentsius) ja Anna Daniela Saalistele (A. D.) Tallinna Linnagaleriis toimunud näitusel eksponeeritud suureformaadiliste maalikompositsioonide 'The End', 'Aadam' ja 'Eeva' eest

  9. Youth subcultures and problem behaviours in Slovakia : Hip-Hop, Techno-scene, Metal, Punk, Skinheads and Roma

    NARCIS (Netherlands)

    Bobakova, Daniela

    2013-01-01

    Jongeren die deel uitmaken van jeugdsubculturen als hip-hop, techno-scene, metal, punk en skinheads, gebruiken vaker drugs, zijn vaker dronken, spijbelen vaker en beginnen eerder aan seks. Roma-jongeren zijn minder vaak dronken. Dat concludeert Daniela Bobáková op basis van een onderzoek onder deze

  10. Unusta, säilita, mäleta : kunstnikud materialiseerivad mälu / Laura Põld

    Index Scriptorium Estoniae

    Põld, Laura, 1984-

    2015-01-01

    Rahvusvaheline näitus "Tracing the Memory" Vaal galeriis 17. detsembrist 2014 kuni 17. jaanuarini 2015, kuraatorid Annika Toots ja Slavomira Ondrušová. Eksponeeriti Daniela Krajčová, Jan Nálevka, Katarina Poliačiková, Laura Tootsi ja Milan Vagač'i installatsioone. Kunstnike eluloolisi andmeid

  11. Modern Czech Studies. Brown Slavic Contributions, Volume XIII.

    Science.gov (United States)

    Levitsky, Alexander, Ed.; Fidler, Masako U., Ed.

    2000-01-01

    The following papers are included: "Responses to the Literature Papers" (Malynne M. Sternstein); "Kitsch and Irony in Kundera: 'The Joke' and 'The Unbearable Lightness of Being'" (Aaron Beaver); "Daniela Fischerova's 'The Message Table': (Lauren McConnell); "Rethinking the Grotesque in Hrabal's Fiction" Carnival…

  12. Unusta, säilita, mäleta : kunstnikud materialiseerivad mälu / Laura Põld

    Index Scriptorium Estoniae

    Põld, Laura, 1984-

    2015-01-01

    Rahvusvaheline näitus "Tracing the Memory" Vaal galeriis 17. detsembrist 2014 kuni 17. jaanuarini 2015, kuraatorid Annika Toots ja Slavomira Ondrušová. Eksponeeriti Daniela Krajčová, Jan Nálevka, Katarina Poliačiková, Laura Tootsi ja Milan Vagač'i installatsioone. Kunstnike eluloolisi andmeid

  13. British Exit from the EU: Legal and Political Implications

    DEFF Research Database (Denmark)

    2016-01-01

    to the three editors of Graham Butler, Mads Dagnis Jensen, and Holly Snaith, the Debate Section includes contributions from Paul James Cardwell, Adam Łazowski, Daniela Annette Kroll, Dirk Leuffen, and Tim Oliver, that each delivers sharp compact contributions on different perspectives of ‘Brexit’, and wider......://dx.doi.org/10.1080/13501763.2016.1174529 4. When politics prevails: the political economy of a Brexit Mads Dagnis Jensen and Holly Snaith Journal of European Public Policy, 2016, Volume 23, Issue 9, pp. 1302-1310. http://dx.doi.org/10.1080/13501763.2016.1174531 5. Ties that bind, can also strangle: the Brexit...... threat and the hardships of reforming the EU Daniela Annette Kroll and Dirk Leuffen Journal of European Public Policy, 2016, Volume 23, Issue 9, pp. 1311-1320. http://dx.doi.org/10.1080/13501763.2016.1174532 6. European and international views of Brexit Tim Oliver Journal of European Public Policy, 2016...

  14. Role of endocannabinoids in regulating drug dependence

    Directory of Open Access Journals (Sweden)

    Daniela Parolaro

    2007-01-01

    Full Text Available Daniela Parolaro, Daniela Vigano’, Natalia Realini, Tiziana RubinoNeuroscience Center, DBSF, University of Insubria, Busto Arsizio, ItalyAbstract: This review will discuss the latest knowledge of how the endocannabinoid system might be involved in treating addiction to the most common illicit drugs. Experimental models are providing increasing evidence for the pharmacological management of endocannabinoid signaling not only to block the direct reinforcing effects of cannabis, opioids, nicotine and ethanol, but also for preventing relapse to the various drugs of abuse, including opioids, cocaine, nicotine, alcohol and metamphetamine. Preclinical and clinical studies suggest that the endocannabinoid system can be manipulated by the CB1 receptor antagonist SR141716A, that might constitute a new generation of compounds for treating addiction across different classes of abused drugs.Keywords: Endocannabinoids, drug dependence, opioids, nicotine, alcohol, psychostimulants

  15. Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab

    OpenAIRE

    Armuzzi A; Pugliese D; Nardone OM; Guidi L

    2013-01-01

    Alessandro Armuzzi, Daniela Pugliese, Olga Maria Nardone, Luisa Guidi IBD Unit, Complesso Integrato Columbus, Catholic University, Rome, Italy Abstract: The treatment of ulcerative colitis has changed over the last decade, with the introduction of biological drugs. This article reviews the currently available therapies for ulcerative colitis and the specific use of these therapies in the management of patients in different settings, particularly the difficult-to-treat patients. The focus of ...

  16. Effects of coping statements on experimental pain in chronic pain patients

    OpenAIRE

    Daniela Roditi; Robinson, Michael E.; Nola Litwins

    2009-01-01

    Daniela Roditi, Michael E Robinson, Nola LitwinsDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USAAbstract: The present study measured the effects of catastrophizing self-statements and positive coping self-statements on cold pressor-induced pain. Participants were 58 adult chronic pain patients with current facial pain. It was hypothesized that catastrophizing would lead to a decrease in pain endurance whereas positive coping would lead to an increase i...

  17. Navigating the Information Revolution: Choices for Laggard Countries

    Science.gov (United States)

    2007-01-01

    0.400 0.500 0.600 0.700 0.800 0.900 Sw ed en Un ite d S tat es Ja pa n Ne the rla nd s No rw ay Ko rea , R ep . Un ite d K ing do m Sin ga po re Ge rm...Case.” Information Systems Journal, Vol. 11, No. 3, pp. 181-212. 117 Beilock, Richard and Daniela V. Dimitrova (2003). “An Exploratory Model of

  18. A Quantitative Approach to the Formal Verification of Real-Time Systems.

    Science.gov (United States)

    1996-09-01

    my parents Lia and Daniel and to my sister Daniela , for the help and support through- out my whole life. Even though they have not been present during...transient overload, scheduling of aperiodic tasks and priority granularity in communication scheduling [49]. For this rea - son, static scheduling algorithms...Quantitative temporal rea - soning. In Lecture Notes in Computer Science, Computer-Aided Verification. Springer- Verlag, 1990. [34] J. Fernandez, H

  19. Progressive retinal detachment secondary to juxtapapillary microholes in association with type 3 posterior staphylomas

    OpenAIRE

    Dinah CB; Vaideanu-Collins D; Steel DHW

    2014-01-01

    Christiana B Dinah,1 Daniela Vaideanu-Collins,2 David HW Steel1,31Ophthalmology Department, Sunderland Eye Infirmary, Sunderland, 2Ophthalmology Department, James Cook University Hospital, Middlesbrough, UK, 3Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UKPurpose: This study describes a novel subtype of retinal detachment occurring in eyes with pathological myopia associated with type 3 posterior staphyloma and discusses the management options.Me...

  20. Degenerate second order mean field games systems

    OpenAIRE

    Tonon, Daniela; Cardaliaguet, Pierre; Graber, Philip,; Poretta, Alessio

    2014-01-01

    Parallel session; International audience; We consider degenerate second order mean field games systems with a local coupling. The starting point is the idea that mean field games systems can be understood as an optimality condition for optimal control of PDEs. Developing this strategy for the degenerate second order case, we discuss the existence and uniqueness of a weak solution as well as its stability (vanishing viscosity limit). Speaker: Daniela TONON

  1. Pegylated liposomal doxorubicin in ovarian cancer

    OpenAIRE

    Matei, Daniela

    2009-01-01

    Robert Strother1,2, Daniela Matei1–51Department of Medicine, 2Indiana University Melvin and Bren Simon Cancer Center, 3Department of Obstetrics and Gynecology, 4Department of Biochemistry and Molecular Biology, 5VA Roudebush Hospital Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN, 46202Abstract: The encapsulation of doxorubicin in a pegylated liposomal matrix led to a reformulated agent with a different toxicity profile and improved clinical utility. Lip...

  2. Mira Miletić-Drder, PhD in Social Sciences

    Directory of Open Access Journals (Sweden)

    Aleksandra Horvat

    2012-06-01

    Full Text Available Mira Miletić-Drder, MSc, graduate professor of geography and history and graduate librarian, defended her doctoral dissertation titled Map Collections in Croatia: a Model of Virtual Connection at the Faculty of Philosophy of the University of Zagreb on February 13, 2012. Hermentor was Prof. Dr. Aleksandra Horvat, and the Committee for evaluating and defence of the dissertation included Prof. Dr. Daniela Živković, Prof. Dr.Miljenko Lapaine and Prof. Dr. Aleksandra Horvat.

  3. Zjawy, upiory, sobowtóry... „Romantyczne” transgresje w powieści "Podobojí" Danieli Hodrovej

    OpenAIRE

    Balcerzak, Małgorzata

    2011-01-01

    This article concentrates on the problem of transgression in the novel Podobojí by Daniela Hodrová. This problem is tracked from the perspective of romantic and post-romantic references to the literary and historical tradition (e.g. the Czech National Revival). One of the key concepts here is death and the metaphor of doubling, which makes the characters in the novel ontologically ambiguous entities. Death is treated in a confrontation with romantic themes, such as the ghost...

  4. Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition

    OpenAIRE

    Perna G; Daccò S; Menotti R; Caldirola D

    2011-01-01

    Giampaolo Perna1-3, Silvia Daccò2, Roberta Menotti2, Daniela Caldirola21Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, the Netherlands; 2Department of Clinical Neuroscience, San Benedetto Hospital, Hermanas Hospitalarias, Albese con Cassano, Como, Italy; 3Department of Psychiatry and Behavioral Sciences, Leonard M Miller School of Medicine, University of Miami, Miami, FL, USABackground: Although the...

  5. Low vision rehabilitation: current perspectives

    OpenAIRE

    Vingolo EM; De Rosa V; Domanico D; Anselmucci F

    2015-01-01

    Enzo Maria Vingolo, Vittoria De Rosa, Daniela Domanico, Federico Anselmucci  Department of Ophthalmology, University La Sapienza of Rome, Terracina, Italy Abstract: Quality of life in low vision patients is deeply conditioned by their visual ability, and increased rates of depression, domestic injury, and need for caregiver assistance can be expected as a result of low performance. Much effort have been made recently in order to develop new tools and aids for rehabilitation of low v...

  6. Share anything Swedish : -En studie av CommunityOfSweden.com

    OpenAIRE

    Brandel, Daniela

    2009-01-01

    Title: Share anything Swedish – a study of CommunityOfSweden.com (Share anything Swedish – en studie av CommunityOfSweden.com). Number of pages: 57 (64 including attachments). Author: Daniela Brandel. Tutor: Else Nygren.Course: Media and Communication Studies C. Period: Fall 2008. University: Division of Media and Communication, Department of Information Science, Uppsala University. Purposes/Aims: To learn what happens when the public-private tourism organisation VisitSweden starts an online ...

  7. The effect of aging, nutrition, and exercise during HIV infection

    OpenAIRE

    Gabriel Somarriba; Daniela Neri; Natasha Schaefer; et al

    2010-01-01

    Gabriel Somarriba, Daniela Neri, Natasha Schaefer, Tracie L MillerDivision of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida, USAAbstract: Medical advances continue to change the face of human immunodeficiency virus–acquired immunodeficiency syndrome (HIV/AIDS). As life expectancy increases, the number of people living with HIV rises, presenting new challenges for the management of a chronic condition. Aging, nut...

  8. Eraldo Affinati. Il "peregrin d'amore" sulle tracce di Bonhoeffer

    Directory of Open Access Journals (Sweden)

    Daniela Orsillo

    2015-07-01

    Full Text Available Daniela Orsillo, authoress of this paper, in December 2014 presented and discussed her Thesis in order to obtain the Licenza Degree in Religious Sciences in the Higher Institute of Religious Sciences “San Roberto Bellarmino” of Capua. The work, entitled Bonhoeffer: il percorso di una vita nella scrittura di un letterato contemporaneo, Eraldo Affinati, was provided, in the Appendix, with an interview with the Roman writer. This interview is published here, preceded by a brief summary of the work of Affinati placed at the center of the Orsillo’s Thesis.L’auteur de ce papier, Daniela Orsillo, en Décembre 2014 a présenté et a discuté sa thèse pour l’obtention du diplôme de Licence canonique en Sciences Religieuses dans l’Institut Superieur de Sciences Religieuses “S. Roberto Bellarmino” de Capua. L’ouvrage, intitulé Bonhoeffer: il percorso di una vita nella scrittura di un letterato contemporaneo, Eraldo Affinati, a été assorti d’un entretien avec M. Affinati. Est publié ici l’entretien, précédée par un bref résumé du texte de M. Affinati qui est au centre de la thèse de M.me Orsillo.L'autrice di questo scritto, Daniela Orsillo, ha presentato nel Dicembre 2014 la sua Tesi per l'ottenimento della Licenza Canonica in Scienze Religiose nell'Istituto Superiore di Scienze Religiose "S: Roberto Bellarmino" di Capua (CE. L'opera, dal titolo Bonhoeffer: il percorso di una vita nella scrittura di un letterato contemporaneo, Eraldo Affinati, aveva in appendice un'intervista con l'Affinati. Qui viene pubblicato il testo dell'intervista, preceduto da un breve riassunto delle idee di Affinati intorno alle quali si è dipanato il lavoro della Tesi.

  9. Eestlased Pekingi biennaalil

    Index Scriptorium Estoniae

    2005-01-01

    20. IX avatud Pekingi II kunstibiennaalist, mille peakuraatoriteks on Jin Shangyi, Liu Dawei ja Feng Yuan. Eestit esindavad biennaalil Leo Lapini maal seeriast "Kood", Jaan Toomiku maal "Mees metsas", Anne-Daniela Saaliste ja Paul Rodgersi kineetiline installatsioon "Karusell". Hefeis toimus IAA (International Association of Art) XVI konverents ja assamblee. IAA uueks esimeheks valiti Liu Dawei Hiinast. Hefei Anmei kunstilinnakus avati 23. VIII näitus peaassambleel esindatud kunstnikeorganisatsioonide delegaatide-kunstnike töödest, kus Eestist oli väljas Jaan Elkeni maal "Preemia"

  10. 2 April 2014 - H. E. Mr Joachim Gauck, President of the Federal Republic of Germany in the ATLAS experimental cavern with Director-General R. Heuer.

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    in the ATLAS cavern: Minister of State at the Federal Foreign Office M. Böhmer (green jacket) and Mrs daniela Schadt (First Lady). 201404-069_39.jpg: State Secretary, Federal Ministry of Education and Research G. Schütte, Minister of State at the Federal Foreign Office M. Böhmer, President Gauck, CERN DG, State Secretary, Chief of the Federal President´s Office D. Gill and Ambassador of the Federal Republic of Germany to the Swiss Confederation O. Lampe.

  11. El devenir animal del sujeto femenino: Tarazona, Lispector, Braidotti

    OpenAIRE

    Francisco Serratos

    2016-01-01

    La obra de la escritora mexicana Daniela Tarazona (1975) guarda ciertas similitudes con la de Clarice Lispector. Ambas recurren a elementos narrativos como la extrañeza y lo fantástico en algunas de sus novelas, pero sobre todo en dos: El animal sobre la piedra (Tarazona) y La pasión según G. H. (Lispector), donde abordan la identidad femenina desde los límites de la biología. Los personajes sufren mutaciones que las llevan a transgredir los roles de género tanto psicológicos, sociales y biol...

  12. A Case Study: The Effects of the British Army against the Irish Republican Army

    Science.gov (United States)

    1989-09-01

    the esc,’alated violi ce caused 17.1 flea t hs compared to 25 deaths in 1970 (,1:107;50: 172). ’I’ll It(. rea e t rie𔃻 t the. [I,- Ire as f, ta . It...18:1). When the bus rea .-ched Lungannon, 5e) miles west of Belfast, a 200-pound IRA bomb planted in a parked car exploded (16:1;17:1). The explosion...95: 463-5 (February 18, 1972). 32. Iacono, Daniela . Story 0174929, Dialog File 260, United Press International (March 4, 1S,5). 33. --.... Story

  13. A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project

    OpenAIRE

    Dörbudak, Zeynep; Leone, Michela; D'Ippoliti, Daniela; De Sario, Manuela; Analitis, Antonis; Menne, Bettina; Katsouyanni, Klea; de'Donato, Francesca K.; Basagana, Xavier; Ben Salah, Afif; Casimiro, Elsa; Iniguez, Carmen; Peretz, Chava; Wolf, Tanja; Michelozzi, Paola

    2013-01-01

    RESEARCH Open Access A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project Michela Leone1*, Daniela D’Ippoliti1, Manuela De Sario1, Antonis Analitis2, Bettina Menne3, Klea Katsouyanni2, Francesca K de’ Donato1, Xavier Basagana4,5,6, Afif Ben Salah7, Elsa Casimiro8, Zeynep Dörtbudak9, Carmen Iñiguez4,10,11, Chava Peretz12, Tanja Wolf3 and Paola Michelozzi1...

  14. Recensione a "Collodi. Edizione Nazionale delle Opere di Carlo Lorenzini. Volume III"

    Directory of Open Access Journals (Sweden)

    Pina Paone

    2013-06-01

    Full Text Available Si presenta il terzo volume della collana Collodi, Edizione Nazionale delle Opere di Carlo Lorenzini, Giunti, Firenze, 2012, con Prefazione di Mario Vargas Llosa e Introduzione di Daniela Marcheschi. Il volume contiene il famosissimo Le Avventure di Pinocchio, sintesi del percorso artistico dello scrittore toscano ed espressione più compiuta della sua abilità e consapevolezza narrativa. La recensione ripercorrerà i tratti dell’opera, inserendola nel generale e più ampio contesto dell’attività letteraria di Collodi.

  15. Kommunikatsioon eeldab keeleoskust / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2008-01-01

    Religiooni ja demokraatia suhteid käsitlevast rahvusvahelisest näitusest "Obscurum per obscurius" Tallinna Kunstihoones. Avatud kuni 06.07.2008. Kuraatorid Ilja Sundelevitsh ja Reet Varblane, kujundaja Liina Siib. 28 osalejat loetletud. Eestist osalevad: Anu Juurak, Leonhard Lapin, Peeter Laurits, Raul Meel, Tatjana Muravskaja, Jüri Ojaver, Terje Ojaver, Anne-Daniela Rodgers & Paul Rodgers, Liina Siib, Jaan Toomik. 28. V toimunud seminarist, kus pikemate ettekannetega esinesid Toomas Paul ja Linnar Priimägi, ning ümarlaua arutelust

  16. Kommunikatsioon eeldab keeleoskust / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2008-01-01

    Religiooni ja demokraatia suhteid käsitlevast rahvusvahelisest näitusest "Obscurum per obscurius" Tallinna Kunstihoones. Avatud kuni 06.07.2008. Kuraatorid Ilja Sundelevitsh ja Reet Varblane, kujundaja Liina Siib. 28 osalejat loetletud. Eestist osalevad: Anu Juurak, Leonhard Lapin, Peeter Laurits, Raul Meel, Tatjana Muravskaja, Jüri Ojaver, Terje Ojaver, Anne-Daniela Rodgers & Paul Rodgers, Liina Siib, Jaan Toomik. 28. V toimunud seminarist, kus pikemate ettekannetega esinesid Toomas Paul ja Linnar Priimägi, ning ümarlaua arutelust

  17. Riia, Euroopa ja euroopalik ruum / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2004-01-01

    Riia skulptuurikvadriennaal "Euroopa ruum" Riia Arsenalis, Läti raudteemuuseumis ja linnaruumis 4. VI-25. VII. Kuraatorid Kristaps Gulbis, Aigars Bikse. Preemia saanud ungari rühmituse Little Warsaw (Balint Havas, Andras Galik) tööst "Marmori tänav" ning Gints Gabransi (Läti), Tulay Schakiri (Soome), Eestit esindanud Daniela, Paul Rodgersi, Ekke Väli, Jüri Ojaveri jt. töödest. Tagasivaates 1950-ndate skulptuuri linnaruumi paigutatud fotode kaudu esindas Eestit Arseni Mölder. Heli Ryhäneni ja Anne Meskaneni näitusest "Skulptuurid" Tallinna Kunstihoone galeriis

  18. Three new species and new distributional records of Oecetis McLachlan 1877 (Trichoptera: Leptoceridae: Leptocerinae) from Brazil.

    Science.gov (United States)

    Henriques-Oliveira, Ana Lucia; Dumas, Leandro Lourenço; Nessimian, Jorge Luiz

    2014-01-07

    The genus Oecetis is widespread over the world, being most diverse in tropical areas, especially in the Australian Region. Of about 400 described species, only 34 occur in the Neotropical Region. Herein, we describe and illustrate three new species of Oecetis from Brazil: Oecetis angelae sp. nov., O. danielae sp. nov. and O. iara sp. nov. Furthermore, O. doesburgi, O. dominguezi, and O. knutsoni are recorded for the first time in Brazil. Also, we provide new state records for 7 species: O. amazonica, O. connata, O. excisa, O. fibra, O. iguazu, O. inconspicua, and O. paranensis.

  19. Eestlased Pekingi biennaalil

    Index Scriptorium Estoniae

    2005-01-01

    20. IX avatud Pekingi II kunstibiennaalist, mille peakuraatoriteks on Jin Shangyi, Liu Dawei ja Feng Yuan. Eestit esindavad biennaalil Leo Lapini maal seeriast "Kood", Jaan Toomiku maal "Mees metsas", Anne-Daniela Saaliste ja Paul Rodgersi kineetiline installatsioon "Karusell". Hefeis toimus IAA (International Association of Art) XVI konverents ja assamblee. IAA uueks esimeheks valiti Liu Dawei Hiinast. Hefei Anmei kunstilinnakus avati 23. VIII näitus peaassambleel esindatud kunstnikeorganisatsioonide delegaatide-kunstnike töödest, kus Eestist oli väljas Jaan Elkeni maal "Preemia"

  20. Proceedings of The 8th Romanian National HIV/AIDS Congress and The 3rd Central European HIV Forum

    OpenAIRE

    Alexiev, Ivailo; Dimitrova, Reneta; Gancheva, Anna; Kostadinova, Asya; Stoycheva, Mariyana; Nikolova, Daniela; Elenkov, Ivaylo; Păunescu, Bogdan; Hristache, Mădălina; Brîndușe, Lăcrămioara Aurelia; Petrea, Sorin; Neagu-Drăghicenoiu, Ruxandra; Chirilă, Odette; Anghelina, Cristian; Coserea, Ileana

    2016-01-01

    O1 HIV-1 diversity in Bulgaria (current molecular epidemiological picture) Ivailo Alexiev, Reneta Dimitrova, Anna Gancheva, Asya Kostadinova, Mariyana Stoycheva, Daniela Nikolova, Ivaylo Elenkov O2 Knowledge, attitudes and practices of the general population on HIV/AIDS, hepatitis B and C in Romania Cătălin Tilișcan, Mioara Predescu, Bogdan Păunescu, Anca Streinu-Cercel, Oana Săndulescu, Claudiu Mihai Șchiopu, Mădălina Hristache, Lăcrămioara Aurelia Brîndușe, Adrian Streinu-Cercel O3 The prev...

  1. Reviews of recent publications

    Directory of Open Access Journals (Sweden)

    2005-06-01

    Full Text Available Edwards, Catherine, ed. Roman Presences: Receptions of Rome in European Culture, 1789-1945. Christina Ujma Gilman, Sander L. and Jurek Becker. A Life in Five Worlds. David Malcolm Rodden, John, ed. Conversations with Isabel Allende. Daniela Melis Schrift, Alan D., ed. Why Nietzsche Still? Reflections on Drama, Culture, and Politics. Jennifer Marston William Viegnes, Michel, ed. Hugo et la chimère. Recherches & Travaux 62. Kathryn M. Grossman Winston, Jane Bradley. Postcolonial Duras: Cultural Memory in Postwar France. Carol J. Murphy

  2. Vulnerability of semi-enclosed marine systems to environmental disturbances

    Digital Repository Service at National Institute of Oceanography (India)

    MacCracken, M.; Escobar-Briones, E.; Gilbert, D.; Korotaev, G.; Naqvi, S.W.A.; Perillo, G.M.E.; Rixen, T.; Stanev, E.; Sundby, B.; Thomas, H.; Unger, D.; Urban, E.R.

    Semi-Enclosed Marine Systems to Environmental Disturbances Michael MacCracken t Elva Escobar-Briones t Denis Gilbert, Gennady Korotaev, Wajih Naqvi, Gerardo M.E. Perillo, Tim Rixen, Emil Stanev, Bj0rn Sundby, Helmuth Thomas t Daniela Unger, and Edward R. Urban, Jr.... Introduction Semi-enclosed marine systems (SEMSs) are impacted on time scales ranging from the very short (days orless) to the very long (decades and beyond) by many ofthe same forces and stresses as other components of the Earth system. Like the open ocean...

  3. A NAÇÃO EM TEMPOS DE DECEPÇÕES E DESILUSÕES

    Directory of Open Access Journals (Sweden)

    Guilherme Carvalho

    2015-12-01

    Full Text Available RESUMO Esta resenha traz uma análise da construção de nação a partir da leitura do filme “Terra estrangeira” dos diretores brasileiros Walter Salles e Daniela Thomas. Verifica-se uma relação entre uma conjuntura político-econômica entre o filme e a realidade português e brasileira, a qual também aponta questões históricas que contribuem para a construção de um autorretrato extremamente crítico e pessimista a partir da trajetória das personagens. Palavras chave: Cinema brasileiro. Nação. Cultura.   ABSTRACTThis review brings a nation’s building analysis about "Foreign Land" the Brazilian movie from Walter Salles and Daniela Thomas.It is a relationship between a political and economic condition between the movie and the Portuguese and Brazilian reality consideringalso the historical issues contributing to building a highly critical and pessimistic self-portrait from the characters trajectory.Key words: Brazilian Cinema. Nation. Culture.  

  4. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

    Directory of Open Access Journals (Sweden)

    Cristian-Mihail Niculae

    2016-11-01

    Full Text Available Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria Alina Cristina Neguț, Oana Săndulescu, Anca Streinu-Cercel, Dana Mărculescu, Magdalena Lorena Andrei, Veronica Ilie, Marcela Popa, Coralia Bleotu, Carmen Chifiriuc, Mircea Ioan Popa, Adrian Streinu-Cercel A3 The utility of inflammatory biomarkers in the prognostic evaluation of septic patients – past, present and future Alina Orfanu, Cristina Popescu, Anca Leuștean, Remulus Catană, Anca Negru, Alexandra Badea, Radu Orfanu, Cătălin Tilișcan, Victoria Aramă, Ştefan Sorin Aramă A4 Etiologic and clinical features of bacterial meningitis in infants Constanța-Angelica Vișan, Anca-Cristina Drăgănescu, Anuța Bilașco, Camelia Kouris, Mădălina Merișescu, Magdalena Vasile, Diana-Maria Slavu, Sabina Vintilă, Endis Osman, Alina Oprea, Sabina Sandu, Monica Luminos A5 The diagnostic and prognostic role of neutrophil to lymphocyte count ratio in sepsis Alina Orfanu, Victoria Aramă, Ştefan Sorin Aramă, Anca Leuştean, Remulus Catană, Anca Negru, Gabriel Adrian Popescu, Cristina Popescu A6 Whooping cough in a HIV positive patient Ramona Georgiana Stanculete, Ana Vaduva Enoiu, Adelina Raluca Marinescu, Voichita Lazureanu A7 Cronobacter sakazakii sepsis in varicella patient Adelina-Raluca Marinescu, Alexandru Crișan, Voichița Lăzureanu, Virgil Musta, Narcisa Nicolescu, Ruxandra Laza A8 Anaerobes an underdiagnosed cause of prosthesis joint infection Anca-Ruxandra Negru, Daniela-Ioana Munteanu, Raluca Mihăilescu, Remulus Catană, Olga Dorobăț, Alexandru Rafila, Emilia Căpraru, Marius Niculescu, Rodica Marinescu, Olivera Lupescu, Vlad Predescu, Adrian Streinu-Cercel, Victoria Aramă, Daniela

  5. New treatment options for nonmetastatic osteosarcoma: focus on mifamurtide in adolescents

    Directory of Open Access Journals (Sweden)

    Huh WW

    2012-09-01

    Full Text Available Winston W Huh, Daniela Egas-Bejar, Peter M AndersonDivision of Pediatrics, The Children's Cancer Hospital of the University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: New treatments are needed to improve the clinical outcome for patients with osteosarcoma. Liposomal muramyl tripeptide phosphatidylethanolamine (mifamurtide is a synthetic peptidoglycan component packaged in multilamellar liposomes. Mifamurtide has been demonstrated to induce recruitment and activation of macrophages and monocytes of the host innate immune system, which leads to antitumoricidal activity. Early clinical trials have demonstrated the safety and tolerability of mifamurtide combined with chemotherapy, and one major study has demonstrated an overall survival benefit in patients with newly diagnosed nonmetastatic osteosarcoma. This review summarizes the mechanism of action, clinical results, and the optimal biologic dose, and raises potential questions for future development of mifamurtide.Keywords: osteosarcoma, childhood cancer, adolescent, sarcoma, immunotherapy, bone

  6. Pneumolabyrinth secondary to temporal bone fracture: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Bacciu A

    2014-09-01

    Full Text Available Andrea Bacciu,1 Vincenzo Vincenti,1 Sampath Chandra Prasad,1 Daniela Tonni,1 Elisa Ventura,2 Salvatore Bacciu,1 Enrico Pasanisi1 1Department of Clinical and Experimental Medicine, Unit of Audiology and Paediatric Otolaryngology, 2Department of Neuroradiology, University Hospital of Parma, Parma, Italy Abstract: Pneumolabyrinth following temporal bone fracture is an extremely rare condition. It results from air entering the inner ear when a communication between the air-filled middle ear spaces and inner ear is established. The imaging modality of choice for pneumolabyrinth is high-resolution computed tomography of the temporal bone. Treatment options include conservative management (bed rest, antibiotics, corticosteroids or surgery (exploratory tympanotomy. We present the case of a 31-year-old female who had pneumolabyrinth secondary to a temporal bone fracture. The patient was treated surgically and made a full clinical recovery. Keywords: pneumolabyrinth, temporal bone fractures, head trauma

  7. Spectrophotometric study of the interaction between arsenic and bovine serum albumin

    Directory of Open Access Journals (Sweden)

    Curvale RA

    2015-08-01

    Full Text Available Rolando A Curvale,1 Nora B Debattista,1 Nora B Pappano,1 Diana M Gonzalez,2 Daniela A Curvale2 1Area of Physical Chemistry, 2Area of Pharmacology and Toxicology, Chemistry, Biochemistry and Pharmacy Faculty, San Luis National University, San Luis, Argentina Abstract: Argentina is one of the countries that are most widely affected by chronic endemic regional hydroarsenicism, a syndrome caused by the constant consumption of water polluted with arsenic at higher levels. In this study, the interaction of bovine serum albumin with arsenite and arsenate was analyzed employing UV-Vis spectroscopy, considering its low cost and greater availability. The number of binding sites, binding constants, and thermodynamic parameters – ΔG°, ΔH°, and ΔS° –were determined. The results obtained indicate that the interaction of bovine serum albumin with arsenate is ionic, while that with arsenite is hydrophobic. Keywords: arsenic, bovine serum albumin, UV spectroscopy, thermodynamic parameters

  8. The macrophages in rheumatic diseases

    Directory of Open Access Journals (Sweden)

    Laria A

    2016-02-01

    Full Text Available Antonella Laria, Alfredomaria Lurati , Mariagrazia Marrazza , Daniela Mazzocchi, Katia Angela Re, Magda Scarpellini Rheumatology Unit, Fornaroli Hospital, Magenta, Italy Abstract: Macrophages belong to the innate immune system giving us protection against pathogens. However it is known that they are also involved in rheumatic diseases. Activated macrophages have two different phenotypes related to different stimuli: M1 (classically activated and M2 (alternatively activated. M1 macrophages release high levels of pro-inflammatory cytokines, reactive nitrogen and oxygen intermediates killing microorganisms and tumor cells; while M2 macrophages are involved in resolution of inflammation through phagocytosis of apoptotic neutrophils, reduced production of pro-inflammatory cytokines, and increased synthesis of mediators important in tissue remodeling, angiogenesis, and wound repair. The role of macrophages in the different rheumatic diseases is different according to their M1/M2 macrophages phenotype. Keywords: macrophage, rheumatic diseases

  9. TEXTBOOKS FOR INITIAL READING AND WRITING FOR STUDENTS WITH MILD INTELLECTUAL DISABILITY INCLUDED IN INCLUSIVE EDUCATION

    Directory of Open Access Journals (Sweden)

    Slavica TODOROVA

    2016-09-01

    Full Text Available Slavica Todorova defended her master's thesis on 30.05.2016 at the Institute of Special Education, Faculty of Philosophy, University "Ss. Cyril and Methodius "- Skopje in front of the commission consisting of Prof. Dr. Natasha Chichevska - Jovanova, Prof. Dr. Zora Jachova and Prof. Dr. Daniela Dimitrova - Radojchikj. The master thesis is a modern, scientific and empirical study presented at 103 pages, structured with an introduction and six chapters: Theoretical foundations of the problem, Research methodology, Analysis of results and discussion, Concluding observations with suggestions, Literature and Annexes. The literature that has been used for preparation of the thesis is composed of 67 bibliographical units in English and Macedonian Language, representing part of the current thematic relevant manuscripts drawn from many research studies and projects implemented in many countries around the world.

  10. Dr. Antonio Roldan Betancur

    Directory of Open Access Journals (Sweden)

    Antonio Roldan Betancur

    1989-02-01

    Full Text Available

    Nació en Briceño, Antioquia, el 17 de febrero de 1946; fueron sus padres Angel e Inés, su esposa Gloria y sus hijas Natalia y Daniela. Bachiller del Liceo Antioqueño: 1964. Médico y Cirujano de la Facultad de Medicina de la Universidad de Antioquia: 1971. Medicatura rural en Betulia, Antioquia: 1971-1972. Médico de planta del Hospital Regional de Urabá: 1972. Alcalde y Concejal de Apartadó. Dirigente deportivo. Gerente de Corpurabá. Director de Coldeportes, Antioquia. Gerente de la Fabrica de Licores de Antioquia. Jefe del Servicio Seccional de Salud de Antioquia. Gobernador del Departamento de Antioquia. Falleció el4 de Julio de 1989.

  11. Percorsi linguistici e semiotici: Critical Multimodal Analysis of Digital Discourse

    Directory of Open Access Journals (Sweden)

    edited by Ilaria Moschini

    2014-12-01

    Full Text Available The language section of LEA - edited by Ilaria Moschini - is dedicated to the Critical Multimodal Analysis of Digital Discourse, an approach that encompasses the linguistic and semiotic detailed investigation of texts within a socio-cultural perspective. It features an interview with Professor Theo van Leeuwen by Ilaria Moschini and four essays: “Retwitting, reposting, repinning; reshaping identities online: Towards a social semiotic multimodal analysis of digital remediation” by Elisabetta Adami; “Multimodal aspects of corporate social responsibility communication” by Carmen Daniela Maier; “Pervasive Technologies and the Paradoxes of Multimodal Digital Communication” by Sandra Petroni and “Can the powerless speak? Linguistic and multimodal corporate media manipulation in digital environments: the case of Malala Yousafzai” by Maria Grazia Sindoni. 

  12. A Decision Making Methodology in Support of the Business Rules Lifecycle

    Science.gov (United States)

    Wild, Christopher; Rosca, Daniela

    1998-01-01

    The business rules that underlie an enterprise emerge as a new category of system requirements that represent decisions about how to run the business, and which are characterized by their business-orientation and their propensity for change. In this report, we introduce a decision making methodology which addresses several aspects of the business rules lifecycle: acquisition, deployment and evolution. We describe a meta-model for representing business rules in terms of an enterprise model, and also a decision support submodel for reasoning about and deriving the rules. The possibility for lifecycle automated assistance is demonstrated in terms of the automatic extraction of business rules from the decision structure. A system based on the metamodel has been implemented, including the extraction algorithm. This is the final report for Daniela Rosca's PhD fellowship. It describes the work we have done over the past year, current research and the list of publications associated with her thesis topic.

  13. L’apprendimento della lingua della medicina in L2: due manuali a confronto

    Directory of Open Access Journals (Sweden)

    Maria Polita

    2013-07-01

    Full Text Available Insegnare la lingua speciale della medicina ad una classe di apprendenti L2 implica considerare diverse problematiche relative alle peculiarità del codice settoriale (variazioni diafasiche, particolarità del lessico, tecnicismi collaterali, ma anche relative al pubblico di apprendenti non italofono (tipologia, interessi, livello di apprendimento. Il panorama editoriale italiano offre pochi strumenti dedicati: tra questi Donatella Troncarelli, Dica 33. Il linguaggio della medicina, Bonacci, 1994 e Daniela Forapani, Italiano per medici, Alma edizioni, 2004. Questo studio intende mettere a confronto i due testi sottolineandone le caratteristiche e l’impostazione glottodidattica ed evidenziando come il contenuto linguistico sia proposto, quali siano le abilità favorite, quali gli obiettivi di apprendimento e quali gli strumenti forniti. Particolare attenzione viene prestata al lessico registrato nei glossari dei volumi.  Learning the language of medicine in l2: a comparison of two textbooks Teaching the special language of medicine to a class of L2 learners implies considering various issues related to the peculiarities of the sector-specific jargon (diphasic variations, peculiarities of vocabulary, collateral technicalities, also related to non-Italian-speaking learners (type, interests, level of learning. Italian publishers offer few dedicated tools: these include Donatella Troncarelli, Dica 33.Il linguaggio della medicina, Bonacci, 1994 and Daniela Forapani, Italiano per medici, Alma editions, 2004. This study aims to compare the two texts, highlighting their features and language teaching setting, showing how linguistic content is proposed, which skills are promoted, what the learning objectives are and what tools are provided. Particular attention is paid to the vocabulary in the glossaries.

  14. Reparación a las víctimas de dictaduras, conflictos armados y violencia política en sus componente de compensación, satisfacción, rehabilitación y no repetición (reparation for victims of dictatorships, armed conflicts and political violence in their components of compensation, satisfaction, rehabilitation, and non-repetition

    Directory of Open Access Journals (Sweden)

    Juan David Villa

    2015-01-01

    Full Text Available Encabezado de página SUSCRIPCIÓN Inicie sesión para verificar la suscripción USUARIO/A Nombre de usuario/a Contraseña No cerrar sesión NOTIFICACIONES Vista Suscribirse IDIOMA Escoge idioma CONTENIDO DE LA REVISTA Buscar Ámbito de la búsqueda Examinar Por número Por autor/a Por título Otras revistas TAMAÑO DE FUENTE Make font size smallerMake font size defaultMake font size larger INFORMACIÓN Para lectores/as Para autores/as Para bibliotecarios/as INICIO ACERCA DE INICIAR SESIÓN BUSCAR ACTUAL ARCHIVOS Inicio > Vol. 15, Núm. 1 (2015 >\tVilla REPARACIÓN A LAS VÍCTIMAS DE DICTADURAS, CONFLICTOS ARMADOS Y VIOLENCIA POLÍTICA EN SUS COMPONENTE DE COMPENSACIÓN, SATISFACCIÓN, REHABILITACIÓN Y NO REPETICIÓN Juan David Villa, Daniela Londoño Díaz, Daniela Barrera Machado Resumen Resumen: El presente texto segundo de dos entregas, realiza un acercamiento a las investigaciones realizadas en la pasada década y a comienzos de la presente sobre los procesos de reparación, en el marco de procesos de justicia transicional en países en procesos que van de la guerra a la paz y de la dictadura a la democracia. Se revisan investigaciones que versan sobre las consecuencias de los procesos de reparación y de transición en las víctimas, en la reconstrucción del tejido social, en la generación de procesos de reconciliación y la transformación del sujeto individual y colectivo. Abstract: This current text, which is the second of two issues, carries out an approach of investigations conducted in the past decade and at the beginning of the present decade on the reparation processes, within the context of transitional justice processes, in countries which are on the way to peace, and from dictatorship to democracy. We review research dealing with the consequences of the reparation and transition processes of victims, in the reconstruction of the social fabric, in the generation of reconciliation processes, and the transformation of the

  15. Kirchengeschichte als Ketzergeschichte Church History as the History of Heretics

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    Susanne Lanwerd

    2006-07-01

    Full Text Available Die katholische Theologin Daniela Müller spricht am Ende ihres Buches von der „Notwendigkeit der Ketzerei“ und begründet diesen Gedanken wie folgt: „‚Ketzer‘ und ‚Ketzerinnen‘ sind die dunklen Geschwister, ohne die man nicht so wäre wie man ist, die man deshalb so bekämpft, weil sie solch starke Gefühle mit uns teilen, weil sie die gleichen Eltern, den gleichen Ursprung haben wie wir und das gleiche Ziel: zur Familie Gottes zu gehören"; die Kirche als „Hüterin der Glaubenswahrheit“ solle daher die „Ketzergeschichte […] in den immerwährenden Prozess der Wahrheitsfindung“ einbeziehen (S. 233 f.. In diesen Prozess will auch die Autorin mit ihrer Studie eingreifen, und zwar am Beispiel der Katharerinnen, deren Geschichte sie für den Zeitraum von 1143 bis 1275 rekonstruiert; sie verfolgt das fragwürdige Ziel, die Geschichte der Katharerinnen im Modus einer emotionalen und identifikatorischen „Aneignung“ dem „eigenen Leben, der eigenen Sinngebung, der eigenen Verarbeitung“ integrieren zu wollen (S. 15.The Catholic theologian Daniela Müller comments at the end of her book on the “importance of heresy” and substantiates this thought as follows: “‘Heretics’ are our sinister siblings without whom we would not be what we are today but with whom we fight nonetheless. They share such strong feelings with us because they have the same parents, the same origin, and the same goal: to belong to the family of God.” Because the church is the “guardian of the truth of belief,” it should include the “history of heresy […] in the perpetual process of searching for the truth” (233. The author wishes to intervene in this process with her study using the example of the Cathars. She reconstructs their history for the time period between 1143 and 1275. She follows the questionable goal of wanting to integrate the history of the Cathars into the mode of emotional and identificatory “appropriation” of

  16. Atti del convegno "Questioni di storia inglese tra Cinque e Seicento: cultura, politica e religione", (Scuola Normale Superiore di Pisa, 11-12 aprile 2002, a cura di Stefano Villani, Stefania Tutino, Chiara Franceschini.

    Directory of Open Access Journals (Sweden)

    Stefano Villani

    2003-01-01

    Full Text Available Mario Rosa, Introduzione. Paolo Cristofolini, Ricordo di un amico. Daniela Bianchi, L'intero libro di Dio, chiamato Bibbia. Alle origini dell'identità puritana. Ginevra Crosignani, Thomas Wright, i suoi scritti ritrovati e il dibattito con Robert Parsons, S. J., sulla partecipazione al servizio e al sermone anglicano. Stefania Tutino, Thomas Pounde, Andrew Willet e la questione cattolica all'inizio del regno di Giacomo I. Chiara Franceschini, Nostalgie di un esule. Note su Giacomo Castelvetro (1546-1616. Eleonora Belligni, Marcantonio De Dominis tra l'Inquisizione romana e Giacomo I: nuove prospettive storiografiche dopo Cantimori. Mauro Simonazzi, La melanconia nell'Inghilterra moderna: Edward Jorden, Timothie Bright e Thomas Adams. Mario Caricchio, Giles Calvert, un "editore d'area" nella rivoluzione inglese. Stefano Villani, "Una piccola epitome di Inghilterra". La comunità inglese di Livorno negli anni di Ferdinando II: questioni religiose e politiche. Luisa Simonutti, William Popple e William Penn. Dalla libertà di coscienza alle libertà civili. Giovanni Tarantino, Libertà di coscienza, 'aritmetica politica' e interesse nazionale: le ragioni economiche della tolleranza nel regno di Giacomo II Stuart. Guglielmo Sanna, Contrattualismo e obbedienza politica nella cultura anglicana degli inizi del Settecento. Dario Pfanner, Charles Blount (1654-1693: la voce di un libero pensatore nella Londra di fine Seicento. Tomaso Cavallo, Aggressore dell'umanità e apologeta della tirannide? L'Hobbes degli enciclopedisti.

  17. Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling

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    Femminella GD

    2014-09-01

    Full Text Available Grazia Daniela Femminella,1 Vincenzo Barrese,2,3 Nicola Ferrara,1,4 Giuseppe Rengo4 1Department of Translational Medical Sciences, Federico II University, Naples, Italy; 2Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy; 3Division of Biomedical Sciences, St George’s University of London, London, UK; 4”Salvatore Maugeri” Foundation – IRCCS – Scientific Institute of Telese Terme, Telese Terme, Benevento, Italy Abstract: Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic differences. Pharmacogenomics is the study of genetic contributions to drug response variability in order to provide evidence for a tailored therapy in an individual patient. Several studies have investigated the pharmacogenomics of the adrenergic receptor system and its role in the context of the use of β-blockers in treating heart failure. In this review, we will focus on the most significant polymorphisms described in the literature involving adrenergic receptors and adrenergic receptor-related proteins, as well as genetic variations influencing β-blocker metabolism. Keywords: adrenergic system, polymorphisms, β-blockers, functional recovery

  18. Surgical and nonsurgical treatment of total rupture of the pectoralis major muscle in athletes: update and critical appraisal

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    Jörn Kircher

    2010-10-01

    Full Text Available Jörn Kircher, Christoph Ziskoven, Thilo Patzer, Daniela Zaps, Bernd Bittersohl, Rüdiger KrauspeUniversity Hospital, Orthopaedic Department, Heinrich-Heine University Düsseldorf, Düsseldorf, GermanyAbstract: The complete rupture of the pectoralis major tendon is an uncommon injury but has become increasingly common among athletes in recent years. This may be due to a higher number of individuals taking part in high-impact sports and weightlifting as well as the use of anabolic substances, which can make muscles and tendons vulnerable to injury. In recent literature, there are only few recommendations to rely on conservative treatment alone, but there are a number of reports and case series recommending early surgical intervention. Comparing the results of the two treatment regimens, there is clear evidence for a superior outcome after surgical repair with better cosmesis, better functional results, regaining of muscle power, and return to sports compared with the conservative treatment. In summary, anatomic surgical repair is the treatment of choice for complete acute ruptures of the pectoralis major tendon or muscle in athletes.Keywords: pectoralis major, rupture, athlete, conservative treatment, surgical treatment, steroid, tendon, sports injury

  19. Effects of coping statements on experimental pain in chronic pain patients

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    Daniela Roditi

    2009-08-01

    Full Text Available Daniela Roditi, Michael E Robinson, Nola LitwinsDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USAAbstract: The present study measured the effects of catastrophizing self-statements and positive coping self-statements on cold pressor-induced pain. Participants were 58 adult chronic pain patients with current facial pain. It was hypothesized that catastrophizing would lead to a decrease in pain endurance whereas positive coping would lead to an increase in pain endurance. It was also hypothesized that catastrophizing would lead to an increase in peak pain intensity whereas positive coping would lead to a decrease in peak pain intensity. At pretest, participants submerged their nondominant hand in the cold pressor. Pain sensitivity ranges (PSR were subsequently determined by calculating the difference between tolerance and threshold times. Ratings of peak pain intensity were measured using a pressure sensitive bladder/transducer. Participants underwent random assignment to either a catastrophizing group or a positive coping self-statement group. ANCOVA results revealed that on average, participants employing catastrophizing statements as a coping strategy experienced significantly lower PSR (M = 35.53, SD = 39.71 compared to participants employing positive coping self-statements (M = 73.70, SD = 86.14 when controlling for pretest PSR. Group assignment had no significant influence on peak pain intensity ratings. Thus, our results reveal that manipulation of coping causes changes in pain endurance.Keywords: catastrophizing, coping, expectation, pain sensitivity

  20. Romanian Association of Balneology Conference – 2015, 28 – 31 May, Băile Tuşnad

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    MUNTEANU Constantin

    2015-05-01

    PERIODONTITIS TREATMENT 17.\tDr. Tatar Daniela Monica, Dr. Dogaru Gabriela, Dr. Ungur Rodica - INFLUENCE OF NATURAL FACTORS ON BRONCHIAL ASTHMA 18.\tIspas Alexandra, Gabriela Dogaru, Motricala Marieta - EFFECTS OF NATURAL THERAPEUTIC FACTORS IN BĂILE TUSNAD ON THE REHABILITATION OF POST-STROKE PATIENTS 19.\tMaria Daniela Crăciun - IMPROVING THE QUALITY OF LIFE IN CLIMAX WITH KINETOTHERAPY AND NATURAL FACTORS IN VATRA DORNEI RESORT 20.\tDenisa Muresan, Gabriela Dogaru, Motricala Marieta - EFFECTIVENESS OF NATURAL THERAPEUTIC FACTORS IN BĂILE TUSNAD FOR THE REHABILITATION OF PATIENTS WITH PARKINSON’S DISEASE 21.\tGabriel Ranghiuc, Roxana Hodorogea, Asist.Dr.BioIng. Cătălina LUCA - STUDIUL TULBURĂRILOR MUSCULO-SCHELETALE UTILIZÂND ELECTROGONIOMETRIA ŞI ELECTROMIOGRAFIA 22.\tMonica Delia POP, Letitia Mihaela Morar - How do we protect ourselves of MALPRACTICE? MEDICAL MALPRACTICE - ACTUALITY, PERSPECTIVES AND SIGNIFICANTLY JURISPRUDENCE 23.\tOctavian D Olariu, Claudia Dascal, Ionut Cadar - REHABILITATION “KEY POINTS” IN ZONE V FLEXOR TENDONS INJURIES 24.\tSuceveanu Mihaela, Pop Dana, Suceveanu Paul, Sitar Tǎut Adela Viviana, Zdrenghea Dumitru, Hâncu Nicolae - EFFECTS OF CARDIOVASCULAR REHABILITATION IN PATIENTS ADMITTED TO THE “Dr Benedek Geza” Hospital of Rehabilitation IN CARDIOVASCULAR Diseases, COVASNA 25.\tCadar D Ionut, Dogaru B Gabriela - THE PHYSICAL THERAPY ROLE IN FUNCTIONAL REHABILITATION AFTER TOTAL SHOULDER ARTHROPLASTY 26.\tDr. Glogojeanu Remus Relu, Dr. Bucur Ileana, Dr. Dogaru Gabriela, Kt. Glogojeanu Olivia Daniela - THE SIGNIFICANT RISKS FOR THE DEVELOPMENT OF OSTEOPOROSIS IN THE AERONAUTICAL PERSONNEL. PREVENTION AND TREATMENT 27.\tTatiana Bihari, Denes Marton, Doina Moldovan - SILICONE IMPLANT ARTHROPLASTY OF THE PROXIMAL INTERPHALANGEAL JOINT (PIPJ OF FINGER V OF THE RIGHT HAND – A THERAPEUTIC VARIANT IN POSTTRAUMATIC ARTHROSIS 28.\tPop Daniela Dogaru Gabriela, Stanescu Ioana, Pop Ioana - ROLE OF MEDICAL REHABILITATION TREATMENT IN POST

  1. AFM, ESEM, TEM, and CLSM in liposomal characterization: a comparative study

    Directory of Open Access Journals (Sweden)

    Barbara Ruozi

    2011-03-01

    Full Text Available Barbara Ruozi1, Daniela Belletti1, Andrea Tombesi2, Giovanni Tosi1, Lucia Bondioli1, Flavio Forni1, Maria Angela Vandelli11Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2C.I.G.S., University of Modena and Reggio Emilia, Modena, ItalyAbstract: An outstanding aspect of pharmaceutical nanotechnology lies in the characterization of nanocarriers for targeting of drugs and other bioactive agents. The development of microscopic techniques has made the study of the surface and systems architecture more attractive. In the field of pharmaceutical nanosystems, researchers have collected vital information on size, stability, and bilayer organization through the microscopic characterization of liposomes. This paper aims to compare the results obtained by atomic force microscopy, environmental scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy to point out the limits and advantages of these applications in the evaluation of vesicular systems. Besides this comparative aim, our work proposes a simple confocal laser scanning microscopy procedure to rapidly and easily detect the liposomal membrane.Keywords: atomic force microscopy, transmission electron microscopy, environmental scanning electron microscopy, confocal laser scanning microscopy

  2. Psychiatric comorbidity and suicide risk in patients with chronic migraine

    Directory of Open Access Journals (Sweden)

    Maurizio Pompili

    2010-04-01

    Full Text Available Maurizio Pompili1,2, Gianluca Serafini1, Daniela Di Cosimo1, Giovanni Dominici1, Marco Innamorati1, David Lester3, Alberto Forte1, Nicoletta Girardi1, Sergio De Filippis4, Roberto Tatarelli1, Paolo Martelletti41Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2McLean Hospital, Harvard Medical School, Boston,  Massachusetts, USA; 3The Richard Stockton College of New Jersey, USA; 4Department of Medical Sciences, Second School of Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, ItalyAbstract: The aim of this study was to explore the impact of mental illness among patients with migraine. We performed MedLine and PsycINFO searches from 1980 to 2008. Research has systematically documented a strong bidirectional association between migraine and psychiatric disorders. The relationship between migraine and psychopathology has often been clinically discussed rather than systematically studied. Future research should include sound methodologically-based studies focusing on the interplay of factors behind the relationship between migraine, suicide risk, and mental illness.Keywords: headache, migraine, suicide*, psychiatric disorders

  3. Fatter, older and slower (and with a trigger)

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    The picture of the Universe has changed since the publication of the Planck results last March. One year earlier, the discovery of the Higgs boson had proved the existence of fundamental “scalar fields” – the most likely reason for why the Universe evolved from the Big Bang to what we observe today. At a workshop organized by the CERN Theory Unit, cosmologists and particle physicists discussed common issues and explored new avenues for better collaboration.   Planck enhanced anomalies. Photo: ESA and the Planck collaboration. “Planck has not been kind to the Universe,” says Daniela Paoletti, a member of the Planck collaboration and a researcher at the Italian National Institute for Astrophysics in Bologna. “We know now that it is fatter because it contains more dark matter than what we had previously calculated; it is also a few hundred thousand years older and is expanding at a slower pace.” What is the Universe ...

  4. Benefit–risk assessment of golimumab in the treatment of refractory ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Pugliese D

    2016-02-01

    Full Text Available Daniela Pugliese, Carla Felice, Rosario Landi, Alfredo Papa, Luisa Guidi, Alessandro Armuzzi Inflammatory Bowel Disease Unit, Complesso Integrato Columbus, Catholic University, Rome, Italy Abstract: Significant advances in the management of patients with ulcerative colitis (UC have been made since the introduction of anti-tumor necrosis factor (TNF-alpha agents, especially for those who fail or do not tolerate conventional therapies. Two drugs, infliximab first, then adalimumab afterward, showed effectiveness in inducing and maintaining long-term remission both in pivotal trials as well as in clinical practice. However, approximately 25% of patients with UC, who fail or do not tolerate all available therapies, require a colectomy for refractory disease. The therapeutic scenario of UC has been recently upgraded by the introduction of golimumab, the latest anti TNF-alpha agent to be approved. Golimumab is a totally humanized monoclonal antibody, administered by a subcutaneous injection every 4 weeks. Treatment with golimumab has shown to be effective to induce sustained clinical benefit in tough-to-treat patients with UC, including steroid and/or immunosuppressive refractory and steroid-dependent patients. In this review, we summarize all available efficacy and safety data of golimumab in UC, analyzing the potential therapeutic position for the treatment of refractory patients with UC. Keywords: ulcerative colitis, refractoriness, anti-TNF-alpha, golimumab 

  5. Current options for the treatment of Paget’s disease of the bone

    Directory of Open Access Journals (Sweden)

    Daniela Merlotti

    2009-07-01

    Full Text Available Daniela Merlotti, Luigi Gennari, Giuseppe Martini, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, ItalyAbstract: Paget’s disease of bone (PDB is a chronic bone remodeling disorder characterized by increased osteoclast-mediated bone resorption, with subsequent compensatory increases in new bone formation, resulting in a disorganized mosaic of woven and lamellar bone at affected skeletal sites. This disease is most often asymptomatic but can be associated with bone pain or deformity, fractures, secondary arthritis, neurological complications, deafness, contributing to substantial morbidity and reduced quality of life. Neoplastic degeneration of pagetic bone is a relatively rare event, occurring with an incidence of less than 1%, but has a grave prognosis. Specific therapy for PDB is aimed at decreasing the abnormal bone turnover and bisphosphonates are currently considered the treatment of choice. These treatments are associated with a reduction in plasma alkaline phosphatase (ALP activity and an improvement in radiological and scintigraphic appearance and with a reduction in bone pain and bone deformity, Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this debilitating disorder.Keywords: Paget’s disease of bone, bisphosphonates, aminobisphosphonates, bone remodeling

  6. El devenir animal del sujeto femenino: Tarazona, Lispector, Braidotti

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    Francisco Serratos

    2017-01-01

    Full Text Available La obra de la escritora mexicana Daniela Tarazona (1975 guarda ciertas similitudes con la de Clarice Lispector. Ambas recurren a elementos narrativos como la extrañeza y lo fantástico en algunas de sus novelas, pero sobre todo en dos: El animal sobre la piedra (Tarazona y La pasión según G. H. (Lispector, donde abordan la identidad femenina desde los límites de la biología. Los personajes sufren mutaciones que las llevan a transgredir los roles de género tanto psicológicos, sociales y biológicos que las encarcelan; para lograrlo, deben transmutar hacia lo animal. Por medio de un método comparativo, se analizan estas dos novelas a través de la filosofía de Rosi Braidotti, quien a su vez retoma las ideas de Gilles Deleuze sobre el devenir-animal y el devenir-mujer.

  7. Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema

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    Gompelmann D

    2014-09-01

    Full Text Available Daniela Gompelmann,1,2 Ralf Eberhardt,1,2 Felix JF Herth1,21Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, Heidelberg, GermanyAbstract: Bronchoscopic thermal vapor ablation (BTVA is an endoscopic lung volume reduction therapy that presents an effective treatment approach in patients with severe upper lobe-predominant emphysema. By instillation of heated water vapor, an inflammatory reaction is induced, leading to fibrosis and scarring of the lung parenchyma, resulting in lobar volume reduction. Clinical single-arm trials demonstrated great outcomes, with significant improvement of lung function, exercise capacity, and quality of life. As the BTVA-induced local inflammatory response that seems to be essential for the desired lobar volume reduction can be associated with transient clinical worsening, strict monitoring of the patients is required. In future, the balance between efficacy and safety will constitute a major challenge. This review summarizes the BTVA procedure, the mechanism of action, and the results of the clinical trials, including the efficacy and safety data.Keywords: emphysema, bronchoscopy, bronchoscopic thermal vapor ablation

  8. Automated tracking of colloidal clusters with sub-pixel accuracy and precision

    Science.gov (United States)

    van der Wel, Casper; Kraft, Daniela J.

    2017-02-01

    Quantitative tracking of features from video images is a basic technique employed in many areas of science. Here, we present a method for the tracking of features that partially overlap, in order to be able to track so-called colloidal molecules. Our approach implements two improvements into existing particle tracking algorithms. Firstly, we use the history of previously identified feature locations to successfully find their positions in consecutive frames. Secondly, we present a framework for non-linear least-squares fitting to summed radial model functions and analyze the accuracy (bias) and precision (random error) of the method on artificial data. We find that our tracking algorithm correctly identifies overlapping features with an accuracy below 0.2% of the feature radius and a precision of 0.1 to 0.01 pixels for a typical image of a colloidal cluster. Finally, we use our method to extract the three-dimensional diffusion tensor from the Brownian motion of colloidal dimers. , which features invited work from the best early-career researchers working within the scope of Journal of Physics: Condensed Matter. This project is part of the Journal of Physics series’ 50th anniversary celebrations in 2017. Daniela Kraft was selected by the Editorial Board of Journal of Physics: Condensed Matter as an Emerging Leader.

  9. Real-time and quantitative fluorescent live-cell imaging with quadruplex-specific red-edge probe (G4-REP).

    Science.gov (United States)

    Yang, Sunny Y; Amor, Souheila; Laguerre, Aurélien; Wong, Judy M Y; Monchaud, David

    2016-12-10

    The development of quadruplex-directed molecular diagnostic and therapy rely on mechanistic insights gained at both cellular and tissue levels by fluorescence imaging. This technique is based on fluorescent reporters that label cellular DNA and RNA quadruplexes to spatiotemporally address their complex cell biology. The photophysical characteristics of quadruplex probes usually dictate the modality of cell imaging by governing the selection of the light source (lamp, LED, laser), the optical light filters and the detection modality. Here, we report the characterizations of prototype from a new generation of quadruplex dye termed G4-REP (for quadruplex-specific red-edge probe) that provides fluorescence responses regardless of the excitation wavelength and modality (owing to the versatility gained through the red-edge effect), thus allowing for diverse applications and most imaging facilities. This is demonstrated by cell images (and associated quantifications) collected through confocal and multiphoton microscopy as well as through real-time live-cell imaging system over extended period, monitoring both non-cancerous and cancerous human cell lines. Our results promote a new way of designing versatile, efficient and convenient quadruplex-reporting dyes for tracking these higher-order nucleic acid structures in living human cells. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio.

  10. Pegylated liposomal doxorubicin in ovarian cancer

    Directory of Open Access Journals (Sweden)

    Robert Strother

    2009-08-01

    Full Text Available Robert Strother1,2, Daniela Matei1–51Department of Medicine, 2Indiana University Melvin and Bren Simon Cancer Center, 3Department of Obstetrics and Gynecology, 4Department of Biochemistry and Molecular Biology, 5VA Roudebush Hospital Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN, 46202Abstract: The encapsulation of doxorubicin in a pegylated liposomal matrix led to a reformulated agent with a different toxicity profile and improved clinical utility. Liposomal doxorubicin is devoid of the cardiac toxicity associated with doxorubicin, but is associated with predictable muco-cutaneous toxicity. The liposomal formulation leads to improved delivery to the target tumor tissue, allowing enhanced uptake by cancer cells. These properties translate into clinical utility in recurrent ovarian cancer as demonstrated by phase II and III trials, this proven clinical efficacy leading to FDA approval in second-line therapy for ovarian cancer. New combinations with cytotoxics, in particular with carboplatin, have demonstrated an acceptable toxicity profile and clinical utility in platinum-sensitive ovarian cancer. A favorable toxicity profile renders liposomal doxorubicin an ideal partner for combination regimens with other cytotoxics, and more recently with biological agents. Such combinations are the subject of ongoing clinical trials.Keywords: ovarian cancer, doxorubicin, liposomes, pegylated liposomal doxorubicin

  11. Power generation prior food safety? Biomass in the conflict area of energy security and hunger crisis; Energieerzeugung vor Ernaehrungssicherung? Biomasse im Spannungsfeld von Energiesicherung und Hungerkrise

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Monika C.M. (ed.)

    2011-07-01

    Within the international meeting of the Evangelische Akademie Loccum (Rehburg-Loccum, Federal Republic of Germany) at 13rd to 15th May, 2009 the following lectures were held: (1) Biomass - Energy of the future (Daniela Thraen); (2) Bio energy and cultivation of energy crops in Lower Saxony. State of the art and perspectives (Gerd Carsten Hoeher); (3) Bioenergy and food security project in FAO (Mirella Salvatore); (4) Appetite for hunger and competition in land use (Elmar Altvater); (5) Biodiesel poles in Northeast Brasilia. Efficiencies and experiences of a project for the integration of small farmers into the national Biodiesel program (Stefan Goertz); (6) Bioenergy in Africa: Chance to overcome energy poverty or driver of hunger (Hamimu Hongo); (7) Cultivation of Jatropha for direct utilization of oil: Win-Win situation for small farmers and companies? (Lorenz Kirchner); (8) Energy security by means of sufficient power generation. Energy and fuels from biomass result in renaissance of the agriculture and offer chances for fight against poverty and for avoidance of hunger to developing countries (Nasir El Bassam).

  12. Peso o risorsa? I saperi della/sulla religione nella scuola e nell’Università

    Directory of Open Access Journals (Sweden)

    Stella Franchella

    2009-07-01

    Full Text Available L’articolo introduce gli interventi presentati al 1° workshop del Convegno di Sociologia della Religione organizzato a Bologna dall'omonima sezione dell'AIS e dal Dipartimento di Scienze dell'Educazione il 28-29 novembre 2008, presso la Facoltà di Scienze della Formazione dell'Alma Mater, sul tema «La religione come fattore di dis/integrazione sociale». Si è trattato di un avvenimento che ha visto, come protagonisti, studiosi di differenti discipline (psicologia, pedagogia, antropologia culturale, sociologia, invitati a riflettere e a proporre nuovi percorsi sperimentali riguardo ad un tema, rilevante oggi come cinque decenni fa. Nel 1959, infatti, Bologna ospitò la 6a conferenza internazionale di Sociologia della Religione (ISSR/SISR, e il tema fu proprio l'integrazione degli immigrati dal Sud e dalle zone rurali nelle città in via di modernizzazione. L’articolo presenta le relazioni di sei studiosi: Flavio Pajer, Alessandro Castegnaro, Cristiana Ottaviano, Mariachiara Giorda, Renzo Guolo, Daniela Conte, che sviluppano il tema del workshop, dal titolo: "Peso o risorsa? I saperi pubblici della/sulla religione".

  13. Crítica de Libros.

    Directory of Open Access Journals (Sweden)

    Ramón Esteban Arnáiz

    1994-01-01

    Full Text Available V. APARICIO BASAURI (coord., Evaluación de servicios de salud mental, Madrid, A.E.N., 1993. Ramón Esteban Arnáiz. Josefina MASS HESSE y Amelia TESORO ARRARTE (coord., Mujer y salud mental. Mitos y realidades, Madrid, A.E.N., 1993. M. López Peña G. LANTERI-LAURA, Les hallucinations, París, Masson, 1991. José María Álvarez Zvi LOTHANE, In defense of Schreber, Nueva Jersey, The Analytic Press, 1991. Martín Lorenzo Vargas Aragón y Jesús María Rodríguez Huidobro. Carmen SÁEZ BUENAVENTURA, ¿La liberación era esto? Mujeres, vidas y crisis, Madrid, Temas de Hoy, 1993. Velia Chavarría Daniela APARICIO Y otros, Salud Mental, Barcelona, Doyma, 1992. José Leal Rubio Jorge ALEMÁN, Cuestiones antifilosóficas de Jacques Lacan, Buenos Aires, Atuel, 1993. Fernando Colina Gilles DELEUZE, Critique et clinique, París, Minuit, 1993. Mauricio Jalón

  14. Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab

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    Armuzzi A

    2013-04-01

    Full Text Available Alessandro Armuzzi, Daniela Pugliese, Olga Maria Nardone, Luisa Guidi IBD Unit, Complesso Integrato Columbus, Catholic University, Rome, Italy Abstract: The treatment of ulcerative colitis has changed over the last decade, with the introduction of biological drugs. This article reviews the currently available therapies for ulcerative colitis and the specific use of these therapies in the management of patients in different settings, particularly the difficult-to-treat patients. The focus of this review is on adalimumab, which has recently obtained approval by the European Medicines Agency and the US Food and Drug Administration, for use in treating adult patients with moderate-to-severe, active ulcerative colitis, who are refractory, intolerant, or who have contraindications to conventional therapy, including corticosteroids and thiopurines. Since the results emerging from the pivotal trials have been subject to some debate, the aim of this review was to summarize all available data on the use of adalimumab in ulcerative colitis, focusing also on a retrospective series of real-life experiences. Taken together, the current evidence indicates that adalimumab is effective for the treatment of patients with different types of ulcerative colitis, including biologically naïve and difficult-to-treat patients. Keywords: randomized controlled trials, real-life experiences

  15. Endoscopic bronchial valve treatment: patient selection and special considerations

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    Eberhardt R

    2015-10-01

    Full Text Available Ralf Eberhardt,1,2 Daniela Gompelmann,1,2 Felix JF Herth,1,2 Maren Schuhmann1 1Pneumology and Critical Care Medicine, Thoraxklinik at the University of Heidelberg, 2Translational Lung Research Center, Member of the German Center for Lung Research, Heidelberg, Germany Abstract: As well as lung volume reduction surgery, different minimally invasive endoscopic techniques are available to achieve lung volume reduction in patients with severe emphysema and significant hyperinflation. Lung function parameters and comorbidities of the patient, as well as the extent and distribution of the emphysema are factors to be considered when choosing the patient and the intervention. Endoscopic bronchial valve placement with complete occlusion of one lobe in patients with heterogeneous emphysema is the preferred technique because of its reversibility. The presence of high interlobar collateral ventilation will hinder successful treatment; therefore, endoscopic coil placement, polymeric lung volume reduction, or bronchoscopic thermal vapor ablation as well as lung volume reduction surgery can be used for treating patients with incomplete fissures. The effect of endoscopic lung volume reduction in patients with a homogeneous distribution of emphysema is still unclear and this subgroup should be treated only in clinical trials. Precise patient selection is necessary for interventions and to improve the outcome and reduce the risk and possible complications. Therefore, the patients should be discussed in a multidisciplinary approach prior to determining the most appropriate treatment for lung volume reduction. Keywords: lung emphysema, valve treatment, collateral ventilation, patient selection, outcome

  16. The effect of aging, nutrition, and exercise during HIV infection

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    Gabriel Somarriba

    2010-09-01

    Full Text Available Gabriel Somarriba, Daniela Neri, Natasha Schaefer, Tracie L MillerDivision of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida, USAAbstract: Medical advances continue to change the face of human immunodeficiency virus–acquired immunodeficiency syndrome (HIV/AIDS. As life expectancy increases, the number of people living with HIV rises, presenting new challenges for the management of a chronic condition. Aging, nutrition, and physical activity can influence outcomes in other chronic conditions, and emerging data show that each of these factors can impact viral replication and the immune system in HIV. HIV infection results in a decline of the immune system through the depletion of CD4+ T cells. From initial infection, viral replication is a continuous phenomenon. Immunosenescence, a hallmark of aging, results in an increased susceptibility to infections secondary to a delayed immune response, and this phenomenon may be increased in HIV-infected patients. Optimal nutrition is an important adjunct in the clinical care of patients with HIV. Nutritional interventions may improve the quality and span of life and symptom management, support the effectiveness of medications, and improve the patient’s resistance to infections and other disease complications by altering immunity. Moderate physical activity can improve many immune parameters, reduce the risk of acute infection, and combat metabolic abnormalities. As people with HIV age, alternative therapies such as nutrition and physical activity may complement medical management.Keywords: HIV replication, aging, diet, nutrition, exercise, immunity

  17. Selective estrogen receptor modulator (SERM for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene

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    Luigi Gennari

    2010-01-01

    Full Text Available Luigi Gennari, Daniela Merlotti, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, ItalyAbstract: Selective estrogen receptor modulators (SERMs represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissuespecific manner. This article reviews lasofoxifene, a new-generation SERM that has completed phase III development for the prevention and treatment of osteoporosis in postmenopausal women. Consistent with preclinical observations, this new SERM demonstrated improved skeletal efficacy over raloxifene and at an oral dose of 0.5 mg/day was effective in the prevention of both vertebral and nonvertebral fractures in postmenopausal women with osteoporosis. At the same dosage, lasofoxifene treatment also reduced estrogen receptor-positive breast cancer risk and the occurrence of vaginal atrophy, but, like the other SERMs, was associated with hot flushes and an increased risk of venous thromboembolic events. With its increased efficacy on the prevention of nonvertebral fractures than current available SERMs and its positive effects on the vagina, this new compound may represent an alternative and cost-effective therapy for osteoporosis in postmenopausal women.Keywords: SERM, lasofoxifene, postmenopausal osteoporosis, fractures, bone density, menopause

  18. Hangout With CERN: LHC and the Grid - Big data, big questions (S02E04)

    CERN Multimedia

    Kahle, Kate

    2013-01-01

    This hangout follows on from "The world is our calculator" hangout http://www.youtube.com/watch?v=t9PQk48VLd8, which showed how global computing helps CERN store, distribute and analysis around 25 Petabytes (25 million Gigabytes) of data generated per year from the Large Hadron Collider. CERN has now passed 100 petabytes http://home.web.cern.ch/about/updates/2013/02/cern-data-centre-passes-100-petabytes so this hangout answers big questions about big data.CMS physicist Seth Zenz speaks to CERN IT expert German Cancio Melia in the CERN computer centre; Luke Kreczko with CMS physicist Freya Blekman at the University of Bristol, UK; Daniela Remenska, LHCb, Grid Tier 1 at NIKHEF, Netherlands; Renato Borges, ALICE, Grid Tier 2 in São Paulo, Brazil; Emir Imamagic, Grid monitoring at SRCE, Croatia. Along with ATLAS physicist Steven Goldfarb joined by new intern Kelly Izlar, and ALICE physicist Ken Read monitoring questions coming in from social media. Recorded live on 14th February 2013.

  19. Low vision rehabilitation: current perspectives

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    Vingolo EM

    2015-08-01

    Full Text Available Enzo Maria Vingolo, Vittoria De Rosa, Daniela Domanico, Federico Anselmucci  Department of Ophthalmology, University La Sapienza of Rome, Terracina, Italy Abstract: Quality of life in low vision patients is deeply conditioned by their visual ability, and increased rates of depression, domestic injury, and need for caregiver assistance can be expected as a result of low performance. Much effort have been made recently in order to develop new tools and aids for rehabilitation of low vision, and this research has led to better knowledge of visual function and increased the likelihood of new therapies in the future. Modern low vision rehabilitation is the result of recent advances in science and technology, and will soon have an important role in people with vision impairment, numbers of whom are likely to increase, give the increasing age of the population. This review outlines scientific developments in low vision rehabilitation based on a search of the literature, covers the role of digital technology and advances in neurofunctional rehabilitation, and the possibility of restoring vision by use of retinal prostheses and cellular therapy. Keywords: AMD, retinal dystrophy, biofeedback training, retinal prosthesis, stem cells

  20. Kirchengeschichte als Ketzergeschichte

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    Susanne Lanwerd

    2006-07-01

    Full Text Available Die katholische Theologin Daniela Müller spricht am Ende ihres Buches von der „Notwendigkeit der Ketzerei“ und begründet diesen Gedanken wie folgt: „‚Ketzer‘ und ‚Ketzerinnen‘ sind die dunklen Geschwister, ohne die man nicht so wäre wie man ist, die man deshalb so bekämpft, weil sie solch starke Gefühle mit uns teilen, weil sie die gleichen Eltern, den gleichen Ursprung haben wie wir und das gleiche Ziel: zur Familie Gottes zu gehören"; die Kirche als „Hüterin der Glaubenswahrheit“ solle daher die „Ketzergeschichte […] in den immerwährenden Prozess der Wahrheitsfindung“ einbeziehen (S. 233 f.. In diesen Prozess will auch die Autorin mit ihrer Studie eingreifen, und zwar am Beispiel der Katharerinnen, deren Geschichte sie für den Zeitraum von 1143 bis 1275 rekonstruiert; sie verfolgt das fragwürdige Ziel, die Geschichte der Katharerinnen im Modus einer emotionalen und identifikatorischen „Aneignung“ dem „eigenen Leben, der eigenen Sinngebung, der eigenen Verarbeitung“ integrieren zu wollen (S. 15.

  1. Profile of lanreotide autogel and its potential in the treatment of gastroenteropancreatic neuroendocrine tumors

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    Rinke A

    2015-09-01

    Full Text Available Anja Rinke, Daniela Müller Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany Abstract: Gastroenteropancreatic neuroendocrine tumors (GEPNETs comprise a heterogenous group of neoplasm, and their incidence is increasing in the population. Approximately one-third of these tumors are associated with characteristic hormonal syndromes like flushing and diarrhea in carcinoid syndrome. Most GEPNETs express receptors for somatostatin. The somatostatin analogs octreotide and lanreotide constituted a major therapeutic advance in palliating hypersecretion syndromes. Lanreotide autogel is a viscous aqueous solution of lanreotide that is usually administered deep subcutaneously every 4 weeks, but extended dosing intervals have also been proposed. In recent years, increasing evidence has supported the use of somatostatin analogs (SSA as antitumor agents. In the double-blind, placebo-controlled, Phase III CLARINET trial, lanreotide autogel 120 mg every 4 weeks was associated with a significant prolongation of progression-free survival in patients with nonfunctioning GEPNETs, with a Ki-67 of <10%. This antiproliferative effect and the favorable toxicity profile make lanreotide autogel attractive for long-term treatment in patients with well-differentiated GEPNETs. Further studies are needed to evaluate the role of lanreotide autogel as a combination partner and the efficacy of high-dose lanreotide. Keywords: neuroendocrine tumor, somatostatin analogs, lanreotide, symptomatic treatment, antiproliferative treatment

  2. The abstracts of evidence-based surgery in Australia (2)%澳大利亚新型干预措施安全性和有效性评价数据库-外科部分2000年年报

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ 2.1.3 腹腔镜结直肠恶性肿瘤切除术 评价组成员: Advisory外科医师 Mr Michel Levitt Protocol外科医师 Mr Peter Hewett Nominated外科医师 Mr Rodnev Woods Other Specialty外科医师 Mr Harry Sheiner ASERNIP-S研究者 Mr Andrew Chapman Mr Daniela DeNichillo Dr Wendy Babidge 主席 Professor Guy Maddern 背景 结肠癌患者的外科治疗包括肿瘤原发灶及局部淋巴结的切除.1991年前进行此类手术需要开腹.经腹腔镜胆囊切除术的成功开展和其他结直肠手术中腹腔镜的应用,特别是可选择的非切除性手术方式,促进了腹腔镜直肠或结肠切除术的发展和进步.

  3. Transformaciones históricas de la cirugía estética como dispositivo de normalización. El caso de la rinoplastia

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    Marcelo Córdoba

    2017-03-01

    Full Text Available En el presente artículo desarrollo una interpretación histórica de la cirugía estética como tecnología normalizadora de la apariencia corporal. El argumento que despliego sostiene que la cirugía estética, en cuanto dispositivo de normalización, funcionó con arreglo a una racionalidad homogeneizadora hasta mediados del siglo pasado, para sobrellevar desde la segunda postguerra un proceso de reconfiguración que llegaría a consolidarse en la actualidad como un régimen de carácter individualizador. Ilustro este argumento a partir de una consideración del sentido y el valor cultural cambiante que en este período recibió la experiencia de la rinoplastia. El método empleado es el análisis comparativo de dos textos producidos en condiciones históricas diversas: por un lado, Transformation and Identity. The Face and Plastic Surgery (1974, de la antropóloga estadounidense Frances Cooke Macgregor; por otro, Hacerse. El viaje de una mujer en busca de la cirugía perfecta (2010, de la periodista argentina Daniela Pasik.

  4. Ebola virus derived G-quadruplexes: Thiazole orange interaction.

    Science.gov (United States)

    Krafčíková, Petra; Demkovičová, Erika; Víglaský, Viktor

    2016-12-13

    The Ebola and Marburg viruses are some of the deadliest viruses in the world. In this study a series of G-rich DNA sequences derived from these types of viruses which possess the potential to form G-quadruplex structures are analyzed. A set of DNA oligonucleotides derived from original viral isolates was used as a representative modeling sequence with which to demonstrate the influence of thiazole orange on circular dichroism (CD) spectral profiles. The results show the unique profile of the induced CD (ICD) signal in the visible region caused by interactions between the ligand and G-quadruplexes. This ligand was found to stabilize the G-quadruplex structure and can also induce topological changes and facilitate G-quadruplex multimerization. Thus, the ICD signatures can be used to determine whether specific unknown sequences can form G-quadruplex motifs. The viral sequences were analyzed using standard spectral and electrophoretic methods. In addition, the ability to target G-quadruplexes located in filoviruses offers researchers attractive therapeutic targets which would be of particular use in the development of novel antiviral therapies. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio.

  5. Management of hereditary angioedema in pregnant women: a review

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    Caballero T

    2014-09-01

    Full Text Available Teresa Caballero,1,2 Julio Canabal,1 Daniela Rivero-Paparoni,1 Rosario Cabañas1 1Hospital La Paz Institute for Health Research, (IdiPaz 2Biomedical Research Network on Rare Diseases-U754 (CIBERER, Madrid, Spain Abstract: Three types of hereditary angioedema (HAE have been described: two are due to C1 inhibitor (C1-INH deficiency (C1-INH-HAE types I and II and one is characterized by normal C1-INH (nC1-INH-HAE. The management of pregnancy in patients with HAE is often a clinical challenge owing to potential worsening of the disease in relation to the physiological increase in estrogens and the limited treatment options. This review addresses the potential influence of pregnancy on the clinical severity of hereditary angioedema and the management of this disease during pregnancy with currently available treatments. Keywords: hereditary angioedema, pregnancy, female, treatment, C1 inhibitor concentrate, tranexamic acid

  6. Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological delivery

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    Matteucci E

    2015-06-01

    Full Text Available Elena Matteucci,1 Ottavio Giampietro,1 Vera Covolan,2 Daniela Giustarini,3 Paolo Fanti,4 Ranieri Rossi3 1Department of Clinical and Experimental Medicine, 2Department of Chemistry and Industrial Chemistry, University of Pisa, 3Department of Life Sciences, Laboratory of Pharmacology and Toxicology, University of Siena, Siena, Italy; 4Division of Nephrology, University of Texas Health Science Center San Antonio, South Texas Veteran Health Care System, San Antonio, Texas, USA Abstract: Insulin is a life-saving medication for people with type 1 diabetes, but traditional insulin replacement therapy is based on multiple daily subcutaneous injections or continuous subcutaneous pump-regulated infusion. Nonphysiologic delivery of subcutaneous insulin implies a rapid and sustained increase in systemic insulin levels due to the loss of concentration gradient between portal and systemic circulations. In fact, the liver degrades about half of the endogenous insulin secreted by the pancreas into the venous portal system. The reverse insulin distribution has short- and long-term effects on glucose metabolism. Thus, researchers have explored less-invasive administration routes based on innovative pharmaceutical formulations, which preserve hormone stability and ensure the therapeutic effectiveness. This review examines some of the recent proposals from clinical and material chemistry point of view, giving particular attention to patients’ (and diabetologists’ ideal requirements that organic chemistry could meet. Keywords: type 1 diabetes mellitus, drug formulations, drug administration routes, insulin, portal system, nanoparticles, biodegradable polymers

  7. City vs mobility Città vs mobilità

    Directory of Open Access Journals (Sweden)

    Rosa Anna La Rocca

    2007-12-01

    Full Text Available The urban planning and the mobility planning are two sectors that have acted as logics before separated and opposite. In a more recent time the two sectors have researched new approaches on the base of an interaction and with the aim to correct the main dysfunctions in the space. But this interaction is not enough and it is necessary to create new interaction kinds based on the assumption that the communication networks do not create the demand, but the demand analysis is a derivative of an authentic knowledge of the territory and of its problems. The Observatories section want to signal and to analyze the national and international tendencies in the interdisciplinary border line represented by the interaction between territorial planning and mobility. Aims of the section are: to inform on the current problematic, on the tendencies and on the evolutive processes; to investigate on the advanced relationships between the two research fields; to explore the interaction fields, the experiences and the possible applications; to highlight the interactions, the disciplinary novelties but, also, the defeats. In the review the task of the section is to stimulate at most the ideas movement and the definition of new point of sights. In it will be present some recoursing references, believed the most profitable for this evolutionary way: they are the research, the planning acts, the actions and the applications. For to be head of the section, the Observatories section will be subdivided in under-sections: the web sites (Cristina Calenda, the publications (Fiorella De Ciutis, the laws and normative (Cristina Calenda, the urban practices (Loredana Travascio, the news and happenings (Milli Trifiletti and a special view on Napoli 2001 (Daniela Cerrone. La pianificazione urbana ed il governo della mobilità sono due settori la cui azione si è svolta secondo logiche separate e

  8. Greenhouse tomato production with electricity generation by roof-mounted flexible solar panels

    Directory of Open Access Journals (Sweden)

    Raúl Ureña-Sánchez

    2012-01-01

    Full Text Available The integration of renewable energy sources into greenhouse crop production in southeastern Spain could provide extra income for growers. Wind energy could be captured by small to medium-sized wind turbines, gas could be produced from biomass, and solar energy could be gathered by solar panels. The aim of this study was to examine the effect of flexible solar panels, mounted on top of a greenhouse for electricity production, on yield and fruit quality of tomatoes (Solanum lycopersycum L., cv Daniela. This study was undertaken in a commercial raspa y amagado greenhouse, typical of the Almería region (Spain. Tomato plantlets were planted at a density of 0.75 plants m-2. The flexible solar panels were mounted on two parts of the roof in different arrangements (T1 and T2, each blacking out 9.8 % of its surface area. A control area (T0 arrangement was fitted with no panels. No difference was found in terms of total or marketable production under these three arrangements, although fruit mean mass and maximum diameter of T0 were significantly greater than T1 and T2. Fruit in T0 matured earlier with more intense color compared with those in T1 and T2. However, these differences had no effect on price as the tomatoes produced under three conditions fell into the same commercial class (G class; diameter 67-81 mm. Solar panels covering 9.8 % roof area of the greenhouse did not affect yield and price of tomatoes despite of their negative effect on fruit size and color.

  9. The melatonergic system: effects on sleep and implications for the treatment of psychiatric disorders

    Directory of Open Access Journals (Sweden)

    De Berardis D

    2011-12-01

    Full Text Available Domenico De Berardis1,2, Tiziano Acciavatti1, Giuseppe Di Iorio1, Mariangela Corbo1, Nicola Serroni2, Daniela Campanella2, Fabiola Di Emidio2, Monica Piersanti3, Marilde Cavuto4, Giovanni Martinotti5, Francesco Saverio Moschetta2, Massimo Di Giannantonio11Department of Neurosciences and Imaging, Chair of Psychiatry, University “G. D'Annunzio”, Chieti; 2NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”; 3NHS, Pharmaceutical Service, Hospital “G. Mazzini”, Teramo; 4IASM, L'Aquila; 5Institute of Psychiatry, Catholic University Medical School, Rome, ItalyAbstract: The circadian pacemaker or biological clock, located in the hypothalamic suprachiasmatic nucleus, is the generation site of circadian rhythms. The light/dark cycle is the circadian pacemaker's dominant synchronizing agent, though it is also influenced by neurotransmitters and the phase-shifting effects of various chemical and pharmacological components, of which melatonin (N-acetyl-5-methoxytryptamine is the most well established. In recent years, melatonin and melatonin analogs have been commercialized in many countries, mainly with hypnotic purposes. A new compound, agomelatine, has been recently synthesized and studied. Among melatonin analogs, this drug possesses unique pharmacological and clinical features; it is an antagonist at 5-HT2B and 5-HT2C receptors and has well established antidepressant and anxiolytic properties. Agomelatine opens new perspectives in the chronobiotic treatment of depression. The purpose of the present review was to elucidate the effects of the melatonergic system on sleep and the implications for the treatment of psychiatric disorders.Keywords: melatonin, agomelatine, circadian rhythms, depression

  10. Behavioral interactions of simvastatin and fluoxetine in tests of anxiety and depression

    Directory of Open Access Journals (Sweden)

    Santos T

    2012-10-01

    Full Text Available Tainaê Santos,1 Monaliza Marizete Baungratz,1 Suellen Priscila Haskel,2 Daniela Delwing de Lima,3 Júlia Niehues da Cruz,4 Débora Delwing Dal Magro,5 José Geraldo Pereira da Cruz51Department of Medicine, 2Department of Physiotherapy, Regional University of Blumenau, Santa Catarina, Brazil; 3Department of Pharmacy, University of Joinville Region, Santa Catarina, Brazil; 4Department of Medicine, University of the Extreme South of Santa Catarina, Santa Catarina, Brazil; 5Department of Natural Sciences, Regional University of Blumenau, Santa Catarina, BrazilAbstract: Simvastatin inhibits 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway, and is widely used to control plasma cholesterol levels and prevent cardiovascular disease. However, emerging evidence indicates that the beneficial effects of simvastatin extend to the central nervous system. The effects of simvastatin combined with fluoxetine provide an exciting and potential paradigm to decreased anxiety and depression. Thus, the present paper investigates the possibility of synergistic interactions between simvastatin and fluoxetine in models of anxiety and depression. We investigated the effects of subchronically administered simvastatin (1 or 10 mg/kg/day combined with fluoxetine (2 or 10 mg/kg at 24, 5, and 1 hour on adult rats before conducting behavioral tests. The results indicate that simvastatin and/or fluoxetine treatment reduces anxiety-like behaviors in the elevated plus-maze and open-field tests. Our results showed that simvastatin and/or fluoxetine induced a significant increase in the swimming activity during the forced swimming test (antidepressant effect, with a concomitant increase in climbing time in simvastatin-treated animals only (noradrenergic activation. We hypothesize that anxiolytic and antidepressant effects of simvastatin and/or fluoxetine produce their behavioral effects through similar mechanisms and provide

  11. The effect of single nucleotide polymorphisms in G-rich regions of high-risk human papillomaviruses on structural diversity of DNA.

    Science.gov (United States)

    Marušič, Maja; Hošnjak, Lea; Krafčikova, Petra; Poljak, Mario; Viglasky, Viktor; Plavec, Janez

    2017-05-01

    Infection with high-risk human papillomaviruses (HPVs) can lead to development of cancer of the head and neck and anogenital regions. G-rich sequences found in genomes of high-risk HPVs can fold into non-canonical secondary structures that could serve as 3D motifs distinct from double-stranded DNA and present recognition sites for ligands and opportunity for gene expression modulation. Combination of UV, CD and NMR spectroscopy and PAGE electrophoresis were used as they offer complementary insights into structural changes of G-rich oligonucleotides. G-rich region of HPV16 is shown to preferentially form hairpin structures, while regions of HPV18, HPV52 and HPV58 fold into four-stranded DNA structures called G-quadruplexes. Single nucleotide polymorphisms found in G-rich sequences have been found to promote formation of hairpin structures of HPV16 and have affected number of species formed in G-rich region of HPV52, whereas they have exhibited minimal effect on the formation of HPV18 and HPV58 G-quadruplex structures. These structural changes were reflected in differences in apparent thermal stabilities. Potential of G-rich sequences as drug targets was evaluated based on the results of the current study. HPV16 and HPV18 are considered less appropriate targets due to several single nucleotide polymorphisms and low stability, respectively. On the other hand, HPV52 and HPV58 could be used for small-molecule mediated stabilization. G-rich sequences occurring in high-risk HPVs can fold into hairpin and G-quadruplex structures that could be potentially utilized as drug targets. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

    Science.gov (United States)

    Amato, Jussara; Pagano, Alessia; Cosconati, Sandro; Amendola, Giorgio; Fotticchia, Iolanda; Iaccarino, Nunzia; Marinello, Jessica; De Magis, Alessio; Capranico, Giovanni; Novellino, Ettore; Pagano, Bruno; Randazzo, Antonio

    2017-05-01

    Guanine-rich DNA motifs can form non-canonical structures known as G-quadruplexes, whose role in tumorigenic processes makes them attractive drug-target candidates for cancer therapy. Recent studies revealed that the folding and unfolding pathways of G-quadruplexes proceed through a quite stable intermediate named G-triplex. Virtual screening was employed to identify a small set of putative G-triplex ligands. The G-triplex stabilizing properties of these compounds were analyzed by CD melting assay. DSC, non-denaturing gel electrophoresis, NMR and molecular modeling studies were performed to investigate the interaction between the selected compound 1 and G-rich DNA structures. Cytotoxic activity of 1 was evaluated by MTT cell proliferation assay. The experiments led to the identification of a promising hit that was shown to bind preferentially to G-triplex and parallel-stranded G-quadruplexes over duplex and antiparallel G-quadruplexes. Molecular modeling results suggested a partial end-stacking of 1 to the external G-triad/G-tetrads as a binding mode. Biological assays showed that 1 is endowed with cytotoxic effect on human osteosarcoma cells. A tandem application of virtual screening along with the experimental investigation was employed to discover a G-triplex-targeting ligand. Experiments revealed that the selected compound actually acts as a dual G-triplex/G-quadruplex stabilizer, thus stimulating further studies aimed at its optimization. The discovery of molecules able to bind and stabilize G-triplex structures is highly appealing, but their transient state makes challenging their recognition. These findings suggest that the identification of ligands with dual G-triplex/G-quadruplex stabilizing properties may represent a new route for the design of anticancer agents targeting the G-rich DNA structures. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B

  13. COMPARATIVE ANALYSIS OF THE STRUCTURE OF THE AMERICAN AND MACEDONIAN SIGN LANGUAGE

    Directory of Open Access Journals (Sweden)

    Aleksandra KAROVSKA RISTOVSKA

    2014-09-01

    Full Text Available Aleksandra Karovska Ristovska, M.A. in special education and rehabilitation sciences, defended her doctoral thesis on 9 of March 2014 at the Institute of Special Education and Rehabilitation, Faculty of Philosophy, University “Ss. Cyril and Methodius”- Skopje in front of the commission composed of: Prof. Zora Jachova, PhD; Prof. Jasmina Kovachevikj, PhD; Prof. Ljudmil Spasov, PhD; Prof. Goran Ajdinski, PhD; Prof. Daniela Dimitrova Radojicikj, PhD. The Macedonian Sign Language is a natural language, used by the community of Deaf in the Republic of Macedonia. This doctoral paper aimed towards the analyses of the characteristics of the Macedonian Sign Language: its phonology, morphology and syntax as well as towards the comparison of the Macedonian and the American Sign Language. William Stokoe was the first one who in the 1960’s started the research of the American Sign Language. He set the base of the linguistic research in sign languages. The analysis of the signs in the Macedonian Sign Language was made according Stokoe’s parameters: location, hand shape and movement. Lexicostatistics showed that MSL and ASL belong to a different language family. Beside this fact, they share some iconic signs, whose presence can be attributed to the phenomena of lexical borrowings. Phonologically, in ASL and MSL, if we make a change of one of Stokoe’s categories, the meaning of the word changes as well. Non-manual signs which are grammatical markers in sign languages are identical in ASL and MSL. The production of compounds and the production of plural forms are identical in both sign languages. The inflection of verbs is also identical. The research showed that the most common order of words in ASL and MSL is the SVO order (subject-verb-object, while the SOV and OVS order can seldom be met. Questions and negative sentences are produced identically in ASL and MSL.

  14. Bazedoxifene for the prevention of postmenopausal osteoporosis

    Directory of Open Access Journals (Sweden)

    Luigi Gennari

    2008-09-01

    Full Text Available Luigi Gennari, Daniela Merlotti, Vincenzo De Paola, Giuseppe Martini, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte 53100-Siena, ItalyAbstract: Bazedoxifene acetate is a novel, chemically distinct selective estrogen receptor modulator (SERM that has been specifically developed after a stringent preclinical screening in order to obtain favorable effects on the skeleton and lipid metabolism with the additional improvement of a neutral effect on hot flushes and without stimulating the uterus or the breast. In both preclinical and clinical studies this SERM was shown to maintain BMD, prevent fractures, and reduce total cholesterol. Moreover, bazedoxifene also showed an improved uterine profile and demonstrated estrogen antagonistic activity on the endometrium. Importantly, this latter capacity has led to the development of a novel class of menopausal therapy called tissue selective estrogen complex (TSEC, in which bazedoxifene is combined with conjugated estrogen. The rationale for selecting bazedoxifene as the SERM in this TSEC combination is that it may offset estrogen stimulation of endometrial and breast tissue, without the necessity of using a progestin in women with an intact uterus, without aggravating menopausal vasomotor symptoms, but with an additive effect on bone. Preliminary data from phase 3 clinical trials appear to confirm this hypothesis, showing a greater effect of bazedoxifene on BMD with respect to raloxifene, coupled with efficacy on menopausal vasomotor symptoms not achieved by SERM alone. These properties and the safety profile of this combination, if confirmed long-term in ongoing phase 3 trials, might significantly affect the way women and physicians approach menopause and its related disorders.Keywords: bazedoxifene, SERM, estrogen, postmenopausal osteoporosis, treatment

  15. Exploring the bacterial microbiota associated with native South American species of Aphis (Hemiptera: Aphididae).

    Science.gov (United States)

    Arneodo, J D; Ortego, J

    2014-06-01

    Aphids harbor a variety of bacterial endosymbionts, including the obligate symbiont Buchnera aphidicola and diverse facultative symbionts. The former supplies its host with essential amino acids. The latter are not indispensable for insect survival, but often improve their host's fitness. To date, the study of such associations was restricted to aphids of Holarctic origin. The bacterial microbiota of seven Aphis species from Argentina was investigated. The presence of B. aphidicola was assessed by specific PCR. Additional symbionts were identified through PCR with eubacterial universal primers, cloning, and sequencing of nearly complete 16S rRNA gene, intergenic spacer region, and partial 23S rRNA gene and subjected to phylogenetic analysis. Infection with B. aphidicola was confirmed in every species analyzed. The facultative symbiont Serratia symbiotica was detected in Aphis malalhuina Mier Durante, Nieto Nafría & Ortego, 2003, Aphis senecionicoides Blanchard, 1944, and Aphis schinifoliae Blanchard, 1939, while Hamiltonella defensa was identified in Aphis mendocina Mier Durante, Ortego & Nieto Nafría, 2006. Arsenophonus sp. was found infecting Aphis melosae Mier Durante & Ortego, 1999, and a new, undescribed Aphis sp. In Aphis danielae Remaudière, 1994, no facultative symbionts could be recorded. When analyzing the highly conserved 16S rRNA gene, the phylogenetic tree grouped the S. symbiotica, H. defensa, and Arsenophonus isolates into three well-defined clusters showing little variability among clones corresponding to the same aphid host species. This article reports for the first time the endosymbionts associated with aphids native to South America. Despite their geographic origin, the qualitative composition of their microbiota revealed no evident differences from that described for aphids in the Northern Hemisphere.

  16. Progressive retinal detachment secondary to juxtapapillary microholes in association with type 3 posterior staphylomas

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    Dinah CB

    2014-06-01

    Full Text Available Christiana B Dinah,1 Daniela Vaideanu-Collins,2 David HW Steel1,31Ophthalmology Department, Sunderland Eye Infirmary, Sunderland, 2Ophthalmology Department, James Cook University Hospital, Middlesbrough, UK, 3Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UKPurpose: This study describes a novel subtype of retinal detachment occurring in eyes with pathological myopia associated with type 3 posterior staphyloma and discusses the management options.Methods: We retrospectively reviewed the case notes of seven patients who presented with unilateral symptomatic rhegmatogenous retinal detachment secondary to nasal juxtapapillary microholes.Results: All seven patients had pathological myopia and an associated peripapillary type 3 posterior staphyloma. They all presented with symptoms of acute posterior vitreous detachment and had progressive retinal detachment. All cases were discovered to have a single juxtapapillary hole less than 1 disc diameter from the optic-nerve head, within areas of nasal chorioretinal atrophy. The microholes were identified intraoperatively in six of seven cases, with one case identified preoperatively on optical coherence tomography. In the four most recent cases, successful retinal reattachment was achieved with vitrectomy and C2F6 gas tamponade. The remaining three cases were managed with vitrectomy and silicone oil.Conclusion: Seven patients with pathological myopia, type 3 posterior staphyloma, and progressive retinal detachment secondary to juxtapapillary microholes are presented in this paper. High clinical suspicion is required to identify these breaks. Successful retinal reattachment with pars plana vitrectomy and long-acting gas is possible.Keywords: pathological myopia, pars plana vitrectomy, long-acting gas, pathological myopia

  17. Influence of nanoparticles on color stability, microhardness, and flexural strength of acrylic resins specific for ocular prosthesis

    Directory of Open Access Journals (Sweden)

    Andreotti AM

    2014-12-01

    Full Text Available Agda Marobo Andreotti, Marcelo Coelho Goiato, Amália Moreno, Adhara Smith Nobrega, Aldiéris Alves Pesqueira, Daniela Micheline dos Santos Araçatuba Dental School, São Paulo State University, Araçatuba, São Paulo, Brazil Abstract: The aim of this study was to assess the effect of adding nanoparticles to N1 acrylic resin intended for artificial sclera, in terms of the color stability, microhardness, and flexural strength of the resin. Three hundred samples of N1 acrylic resin were used: 100 samples for color stability and microhardness tests (each test was performed on the opposite side of each sample, and 200 samples for flexural strength testing (100 samples before and after 1,008 hours of accelerated aging. Samples for each test were separated into ten groups (n=10, ie, without nanoparticles (control group or with nanoparticles of zinc oxide, titanium dioxide (TiO2, and barium sulfate at weight concentrations of 1%, 2%, and 2.5% (nanoparticle groups. Data were subjected to statistical analysis with nested analysis of variance and Tukey’s test (P<0.05 significance level. Among the nanoparticle groups, the TiO2 groups showed better color stability at all concentrations. Microhardness values increased after artificial aging, except for the control and zinc oxide groups. After aging, the 1%–2% TiO2 groups had significantly higher microhardness values compared with the other nanoparticle groups. Before aging, there was a significant difference in flexural strength between the control and nanoparticle groups. After aging, the control and TiO2 groups, regardless of concentration, showed the lowest flexural strength values. Incorporation of nanoparticles directly influenced the acrylic resin properties, with TiO2 being the most influential nanoparticle in terms of the evaluated properties. Keywords: acrylic resins, eye, artificial, color, hardness, nanoparticles

  18. Plántulas de tomate (Solanum lycopersicum L. provenientes de semillas embebidas en diferentes soluciones de giberelinas (GA3

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    Balaguera-López Helber Enrique

    2009-04-01

    Full Text Available

    La obtención de plántulas de tomate vigorosas y en menor tiempo para el trasplante se ha convertido en un factor clave a la hora de iniciar la producción. Con el fin de disminuir el efecto postrasplante e impulsar el desarrollo vegetativo de las plántulas, se sometieron semillas del híbrido larga vida Daniela a imbibición (6, 12, 18, 24, 30 y 36 horas en tres concentraciones de ácido giberélico (300, 600 y 900 mg L-1 y se sembraron en bandejas. Se utilizó un diseño completamente aleatorizado, 18 tratamientos más un testigo con cuatro repeticiones durante cuatro semanas, primera fase. Luego en segunda fase, se trasplantaron cuatro plantas al azar por tratamiento en bolsas de polietileno, y cuatro semanas después se evaluaron. El tratamiento de 36 horas de imbibición y 300 mg L-1 de GA3 mostró diferencias estadísticas en la primera fase para el área foliar, masa fresca de hojas, tallo y raíces y longitud de raíces, y en la segunda fase en la masa seca de hojas, tallo y raíz y en el área foliar. Semillas de tomate embebidas en 300 mg L-1 de GA3 generan plántulas con mayor vigor.

  19. Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder

    Directory of Open Access Journals (Sweden)

    Bersani FS

    2015-11-01

    Full Text Available Francesco Saverio Bersani, Amedeo Minichino, Francesco Fattapposta, Laura Bernabei, Francesco Spagnoli, Daniela Mannarelli, Marta Francesconi, Caterina Pauletti, Alessandra Corrado, Lucilla Vergnani, Ines Taddei, Massimo Biondi, Roberto Delle Chiaie Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy Introduction: Neurocognitive impairments have been observed in patients with bipolar disorder (BD even during the euthymic phase of the disease, potentially representing trait-associated rather than state-associated characteristics of the disorder. In the present study, we used transcranial direct current stimulation (tDCS applied to cerebellar and prefrontal cortices to improve the neurophysiological performances of patients with euthymic BD.Methods: Twenty-five outpatients with BD underwent open-label prefrontocerebellar tDCS for 3 consecutive weeks. Neurophysiological performances were assessed through the examination of the P3b and P3a subcomponents of P300 event-related potential at baseline and after stimulation.Results: Compared to baseline, P3b component after tDCS showed significantly higher amplitude and shorter latency (latency: Fz P=0.02, Cz P=0.03, and Pz P=0.04; amplitude: Fz P=0.24, Cz P=0.02, and Pz P=0.35.Conclusion: In our sample of patients with euthymic BD, concomitant prefrontoexcitatory and cerebellar-inhibitory modulations led to improved brain information processing stream. This improvement may at least partially result from neuroplastic modulation of prefrontocerebellar circuitry activity. Keywords: mood disorders, tDCS, cerebellum, P300, dorsolateral prefrontal cortex, event-related potentials

  20. Managing the pediatric patient with celiac disease: a multidisciplinary approach

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    Isaac DM

    2016-10-01

    Full Text Available Daniela Migliarese Isaac,1 Jessica Wu,2 Diana R Mager,3,4 Justine M Turner1 1Department of Pediatric Gastroenterology and Nutrition, Faculty of Medicine and Dentistry, University of Alberta; 2Alberta Health Services–Child Health Nutrition Services, Stollery Children’s Hospital; 3Department of Agriculture, Food and Nutritional Science; 4Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Abstract: Celiac disease (CD is an autoimmune reaction to gluten, leading to intestinal inflammation, villous atrophy, and malabsorption. It is the most common autoimmune gastrointestinal disorder, with an increasing prevalence. A life-long gluten-free diet (GFD is an effective treatment to alleviate symptoms, normalize autoantibodies, and heal the intestinal mucosa in patients with CD. Poorly controlled CD poses a significant concern for ongoing malabsorption, growth restriction, and the long-term concern of intestinal lymphoma. Achieving GFD compliance and long-term disease control poses a challenge, with adolescents at particular risk for high rates of noncompliance. Attention has turned toward innovative management strategies to improve adherence and achieve better disease control. One such strategy is the development of multidisciplinary clinic approach, and CD is a complex life-long disease state that would benefit from a multifaceted team approach as recognized by multiple national and international bodies, including the National Institutes of Health. Utilizing the combined efforts of the pediatric gastroenterologist, registered dietitian, registered nurse, and primary care provider (general practitioner or general pediatrician in a CD multidisciplinary clinic model will be of benefit for patients and families in optimizing diagnosis, provision of GFD teaching, and long-term adherence to a GFD. This paper discusses the benefits and proposed structure for multidisciplinary care in improving management of CD. Keywords: celiac disease

  1. Greenhouse tomato production with electricity generation by roof-mounted flexible solar panels

    Energy Technology Data Exchange (ETDEWEB)

    Urena-Sanchez, Raul; Callejon-Ferre, Angel Jesus; Perez-Alonso, Jose; Carreno-Ortega, Angel [University of Almeria, Depto. de Ingenieia Rural, Almeria (Spain)], E-mail: acallejo@ual.es

    2012-07-15

    The integration of renewable energy sources into greenhouse crop production in southeastern Spain could provide extra income for growers. Wind energy could be captured by small to medium-sized wind turbines, gas could be produced from biomass, and solar energy could be gathered by solar panels. The aim of this study was to examine the effect of flexible solar panels, mounted on top of a greenhouse for electricity production, on yield and fruit quality of tomatoes (Solanum lycopersicum L., cv Daniela). This study was undertaken in a commercial raspa y amagado greenhouse, typical of the Almeria region (Spain). Tomato plantlets were planted at a density of 0.75 plants m{sup -2}. The flexible solar panels were mounted on two parts of the roof in different arrangements (T1 and T2), each blacking out 9.8 % of its surface area. A control area (T0 arrangement) was fitted with no panels. No difference was found in terms of total or marketable production under these three arrangements, although fruit mean mass and maximum diameter of T0 were significantly greater than T1 and T2. Fruit in T0 matured earlier with more intense color compared with those in T1 and T2. However, these differences had no effect on price as the tomatoes produced under three conditions fell into the same commercial class (G class; diameter 67-81 mm). Solar panels covering 9.8 % roof area of the greenhouse did not affect yield and price of tomatoes despite of their negative effect on fruit size and color. (author)

  2. Lasofoxifene: Evidence of its therapeutic value in osteoporosis

    Directory of Open Access Journals (Sweden)

    Luigi Gennari

    2009-07-01

    Full Text Available Luigi Gennari, Daniela Merlotti, Vincenzo De Paola, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte 53100-Siena, ItalyIntroduction: Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. It is a common disorder in elderly subjects and represents a major public health problem, affecting up to 40% postmenopausal women and 15% of men. Among the several therapeutical interventions, hormone replacement therapy (HRT was traditionally seen as the gold standard for preventing osteoporotic fractures in postmenopausal women, as well as for the management of menopausal symptoms. However HRT, especially if administered long-term, may lead to an increased risk of breast and, when unopposed by progestins, endometrial cancers. Alternative therapies include bisphosphonates and raloxifene, a selective estrogen receptor modulator (SERM. While the former have been associated with suboptimal adherence, the latter was considerably less potent than estrogen and its effect in the prevention of nonvertebral fractures remain uncertain. Aims: The purpose of this article is to review the clinical trials of lasofoxifene, a new SERM for the treatment of postmenopausal osteoporosis. The medical literature was reviewed for appropriate articles containing the terms “lasofoxifene” and SERMs”. Evidence review: There are three (phase II or phase III clinical trials that clearly demonstrate efficacy and safety of this new SERM in the suppression of bone loss and the prevention of vertebral and nonvertebral fractures. Moreover, lasofoxifene treatment also reduced breast cancer risk and the occurrence of vaginal atrophy.Place in therapy: With its increased potency and efficacy on the prevention of nonvertebral fractures lasofoxifene may be an alternative and cost-effective therapy for osteoporosis in postmenopausal women

  3. G-quadruplex fluorescence sensing by core-extended naphthalene diimides.

    Science.gov (United States)

    Zuffo, Michela; Doria, Filippo; Botti, Silvia; Bergamaschi, Greta; Freccero, Mauro

    2017-05-01

    Fluorescent sensing of G-quadruplex nucleic acids (G4s) is an effective strategy to elucidate their role in vitro and in vivo. Small molecule ligands have often been exploited, producing an emission light up upon binding. Naphthalene diimides (NDIs), although potent G4 binders exhibiting red-NIR fluorophores, have only been marginally exploited, as they are usually quenched upon binding. Contrary, aggregating core-extended naphthalene diimides (cex-NDIs) proved to be effective probes. We prepared a library of eighteen cex-NDIs by organic synthesis, characterising their aggregation-dependent absorption and emission properties. Absorption and emission titrations, fluorescent intercalator displacement assay (FID) and circular dichroism (CD) analysis were performed to elucidate their behavior as G4 fluorescent sensors, selectivity and binding mode. cex-NDIs aggregate under aqueous solvents and as a result, their fluorescence is mostly quenched under physiological conditions. Upon G4 binding, they disaggregate into binding monomers, producing a fluorescent light-up with anti-parallel and hybrid G4s. Contrary, with parallel G4s a light-off was recorded. For the formers a groove-like interaction was inferred by ICD signals, while for the latter an end-stacking interaction mode was hypothesized by G4-FID data. cex-NDIs G4 sensing mechanism works via a induced disaggregation. The emission response depends on the G4 topology, which dictates the prevailing -groove or end-stacking- binding mode. This study highlights the potential of cex-NDIs as G4 fluorescent probes. Besides being readily synthesized and conveniently emitting above 600nm, they light-up upon binding to anti-parallel and hybrid G4, complementing a number of other probes' selectivity for the parallel topology. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Managing refractory glaucoma with a fixed combination of bimatoprost (0.03% and timolol (0.5%

    Directory of Open Access Journals (Sweden)

    Moataz E Gheith

    2008-03-01

    Full Text Available Moataz E Gheith, Jason R Mayer, Ghada A Siam, Daniela S Monteiro de Barros,  Tricia L Thomas, L Jay KatzFrom the Glaucoma Service Department of Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USAAbstract: Glaucoma is a chronic progressive optic neuropathy characterized by progressive loss of retinal ganglion cells, which manifests clinically with loss of optic disc neuroretinal rim tissue, defects in the retinal nerve fiber layer, and deficits on functional visual field testing. The goal of glaucoma treatment is to reduce the intraocular pressure to a level that prevents or minimizes the progressive loss of vision. The current standard of management for the newly diagnosed primary open angle glaucoma (PAOG patient is to start topical medication. Available topical medications include: beta-adrenergic antagonists, alpha-adrenergic agonists, carbonic anhydraze inhibitors, prostaglandin analogues and miotics. In some patients, IOP is not adequately controlled by monotherapy. In those refractory patients, where more efficacy is required, shifting to another medication or adding a second medication is indicated. The complimentary action between two drugs serves as the basis for combination medications. One avenue of delivering a second medication is through a fixed combination medication that has the advantage of providing two medicines within one drop. Bimatoprost/timolol represents a new fixed combination which is clinically and statistically more effective than either of its active constituents for patients with refractory glaucoma. As regard the safety of the combination, there were no signs or symptoms of intolerance and the incidence of conjunctival hyperemia was clinically and statistically significantly less than each of the two components separately. Bimatoprost/timolol fixed combination offers cost and time savings, which may enhance compliance; also reducing the amount of preservative applied to the eye, will improve

  5. Obstructive sleep apnea and bone mineral density in obese patients

    Directory of Open Access Journals (Sweden)

    Mariani S

    2012-11-01

    Full Text Available Stefania Mariani,1 Daniela Fiore,1 Laura Varone,2 Sabrina Basciani,1 Agnese Persichetti,1 Mikiko Watanabe,1 Maurizio Saponara,3 Giovanni Spera,1 Costanzo Moretti,4 Lucio Gnessi11Department of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, Italy; 2Department of Environmental Biology, Sapienza University of Rome, Italy; 3Department of Otolaryngology, Audiology and Phonation, Sapienza University of Rome, Italy; 4Division of Endocrinology, Department of System Medicine, Section of Reproductive Endocrinology University of TorVergata, Fatebenefratelli Hospital "San Giovanni Calibita" Rome, ItalyContext: Obesity and its co-morbidities may adversely affect bone mineral density (BMD. Obstructive sleep apnea (OSA is a major complication of obesity. To date, the effects of OSA on BMD in obese patients have been poorly studied.Objective: To examine whether the severity of OSA independently correlates with BMD in obese patients.Methods: One hundred and fifteen obese subjects with OSA (Apnea/Hypopnea Index [AHI] ≥5 events per hour were included in the study. BMD was measured at lumbar spine, total hip, and femoral neck by dual energy X-ray absorptiometry. Body mass index, lean mass, and representative measures of metabolic syndrome (waist circumference, fasting plasma glucose, blood pressure, HDL-cholesterol, triglycerides and inflammation (ESR, CRP, fibrinogen were also evaluated.Results: BMD did not differ among obese individuals regardless of OSA severity. Correlation coefficient analysis for all the covariates showed a lack of association between AHI and BMD that was strongly influenced by age and weight.Conclusion: Our study does not support an independent association between AHI and BMD in obese patients. Controlled studies involving a greater number of patients are warranted.Keywords: obesity, polysomnography, metabolic syndrome

  6. AstroArts

    Science.gov (United States)

    De Paulis, D.

    2014-04-01

    AstroArts is the international, online cultural platform of Astronomers Without Borders (AWB). Cofounded in 2012 by visual artist Daniela de Paulis (IT/NL) and astronomer Thilina Heenatigala (Sri Lanka), AstroArts features creative works inspired by astronomy . AstroArts is an international initiative - lead by professionals working in different fields - and includes the 'guest artist of the month' and the Global Astronomy Month programmes. For the 'guest of the month', we feature one artist through a series of weekly blog posts and a Google Hangout on the last week of each month. The Hangout usually includes guests from several of the AWB ongoing programmes, together with the artist, in order to foster collaboration and interdisciplinary discussion. The 'guest of the month' programme is currently expanding to include a virtual residency initiative, which will allow one artist at the time to develop a project in collaboration with scientists affiliated with the AWB network. The projects developed as part of the virtual residency will foster global participation, making the most of online resources. Global Astronomy Month (GAM) is the most popular project of Astronomers Without Borders: founded in 2009 as a follow up of the International Year of Astronomy, GAM is a global platform for astronomy related events that take place every year in April. During GAM, AstroArts is widely featured through online panel discussions with artists and scientists, live film screenings and live performances, often especially designed for web streaming. More information on AstroArts can be found on: http://astronomerswithoutborders.org/news.htm

  7. La nueva Ley Concursal: Aspectos notariales

    Directory of Open Access Journals (Sweden)

    María del Carmen Acuña

    2014-04-01

    Full Text Available Esta es un exposición que en el marco del ciclo “Derecho y Actualidad” organizado por nuestra Facultad de Derecho, se presenta para todos sus egresados, tanto abogados como escribanos.Puede llamar la atención la inclusión de éstos últimos, en virtud de que la ley concursal regula preferentemente una materia contenciosa.Sin embargo, las razones son importantes y hacen legítima su inclusión en estas actividades de actualización.En primer lugar, todos los operadores de Derecho debemos conocer la Ley y el Escribano es un Operador de Derecho.En segundo lugal, la Función notarial no es solamente formativa y autenticante. El Uruguay tiene función notarial completa, la cual comprende también el área de asesoramiento.Esta área de la función notarial suele ser relegada por la mayoría de los Escribanos, dejándola circunscripta a aquellos involucrados en la actividad académica. Creemos que esa actitud es equivocada.Parte 1: Principios de la Ley ConcursalExpositora: María del Carmen AcuñaParte 2: La actuación notarial en el Proceso ConcursalExpositora: Daniela CianciaruloParte 3: La venta en bloque de la empresa en funcionamientoExpositora: Adriana AmadoParte 4: Legitimación del deudor para disponer y obligara la masa del Concurso en la Ley 18.374Expositora: María Wonsiak

  8. La nueva Ley Concursal: Aspectos notariales

    Directory of Open Access Journals (Sweden)

    María del Carmen Acuña

    2014-04-01

    Full Text Available Esta es un exposición que en el marco del ciclo “Derecho y Actualidad” organizado por nuestra Facultad de Derecho, se presenta para todos sus egresados, tanto abogados como escribanos.Puede llamar la atención la inclusión de éstos últimos, en virtud de que la ley concursal regula preferentemente una materia contenciosa.Sin embargo, las razones son importantes y hacen legítima su inclusión en estas actividades de actualización.En primer lugar, todos los operadores de Derecho debemos conocer la Ley y el Escribano es un Operador de Derecho.En segundo lugal, la Función notarial no es solamente formativa y autenticante. El Uruguay tiene función notarial completa, la cual comprende también el área de asesoramiento.Esta área de la función notarial suele ser relegada por la mayoría de los Escribanos, dejándola circunscripta a aquellos involucrados en la actividad académica. Creemos que esa actitud es equivocada.Parte 1: Principios de la Ley ConcursalExpositora: María del Carmen AcuñaParte 2: La actuación notarial en el Proceso ConcursalExpositora: Daniela CianciaruloParte 3: La venta en bloque de la empresa en funcionamientoExpositora: Adriana AmadoParte 4: Legitimación del deudor para disponer y obligara la masa del Concurso en la Ley 18.374Expositora: María Wonsiak

  9. Interreality: the experiential use of technology in the treatment of obesity.

    Science.gov (United States)

    G, Riva; B K, Wiederhold; F, Mantovani; A, Gaggioli

    2011-03-04

    FOR MANY OF US, OBESITY IS THE OUTCOME OF AN ENERGY IMBALANCE: more energy input than expenditure. However, our waistlines are growing in spite of the huge amount of diets and fat-free/low-calorie products available to cope with this issue. Even when we are able to reduce our waistlines, maintaining the new size is very difficult: in the year after the end of a nutritional and/or behavioral treatment obese persons typically regain from 30% to 50% of their initial losses. A possible strategy for improving the treatment of obesity is the use of advanced information technologies. In the past, different technologies (internet, virtual reality, mobile phones) have shown promising effects in producing a healthy lifestyle in obese patients. Here we suggest that a new technological paradigm - Interreality - that integrates assessment and treatment within a hybrid experiential environment - including both virtual and real worlds - has the potential to improve the clinical outcome of obesity treatments. The potential advantages offered by this approach are: (a) an extended sense of presence: Interreality uses advanced simulations (virtual experiences) to transform health guidelines and provisions in experiences; (b) an extended sense of community: Interreality uses virtual communities to provide users with targeted - but also anonymous, if required - social support in both real and virtual worlds; (c) real-time feedback between physical and virtual worlds: Interreality uses bio and activity sensors and devices (smartphones) both to track in real time the behavior/health status of the user, and to provide targeted suggestions and guidelines. This paper describes in detail the different technologies involved in the Interreality vision. In order to illustrate the concept of Interreality in practice, a clinical scenario is also presented and discussed: Daniela, a 35-year-old fast-food worker with obesity problems.

  10. RTOPO-1: A consistent dataset for Antarctic ice shelf topography and global ocean bathymetry

    Science.gov (United States)

    Timmermann, Ralph

    2010-05-01

    Sub-ice shelf circulation and freezing/melting rates depend critically on an accurate and consistent representation of cavity geometry (i.e. ice-shelf draft and ocean bathymetry). Existing global or pan-Antarctic data sets have turned out to contain various inconsistencies and inaccuracies. The goal of this work is to compile independent regional fields into a global data set. We use the S-2004 global 1-minute bathymetry as the backbone and add an improved version of the BEDMAP topography for an area that roughly coincides with the Antarctic continental shelf. Locations of the merging line have been carefully adjusted in order to get the best out of each data set. High-resolution gridded data for the Amery, Fimbul, Filchner-Ronne, Larsen C and George VI Ice Shelves and for Pine Island Glacier have been carefully merged into the ambient ice and ocean topographies. Multibeam ship survey data for bathymetry in the former Larsen B cavity and the southeastern Bellingshausen Sea have been obtained from the data centers of Alfred Wegener Institute (AWI), British Antarctic Survey (BAS) and Lamont-Doherty Earth Observatory (LDEO), gridded, and again carefully merged into the existing bathymetry map. The resulting global 1-minute data set contains consistent masks for open ocean, grounded ice, floating ice, and bare land surface. The Ice Shelf Cavern Geometry Team: Anne Le Brocq, Tara Deen, Eugene Domack, Pierre Dutrieux, Ben Galton-Fenzi, Dorothea Graffe, Hartmut Hellmer, Angelika Humbert, Daniela Jansen, Adrian Jenkins, Astrid Lambrecht, Keith Makinson, Fred Niederjasper, Frank Nitsche, Ole Anders Nøst, Lars Henrik Smedsrud, and Walter Smith

  11. The impact of shift work on the psychological and physical health of nurses in a general hospital: a comparison between rotating night shifts and day shifts

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    Ferri P

    2016-09-01

    Full Text Available Paola Ferri,1 Matteo Guadi,1 Luigi Marcheselli,1 Sara Balduzzi,1 Daniela Magnani,1 Rosaria Di Lorenzo2 1Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, 2Department of Mental Health, AUSL di Modena, Service of Psychiatric Diagnosis and Treatment, Modena, Italy Background: Shift work is considered necessary to ensure continuity of care in hospitals and residential facilities. In particular, the night shift is one of the most frequent reasons for the disruption of circadian rhythms, causing significant alterations of sleep and biological functions that can affect physical and psychological well-being and negatively impact work performance.Objectives: The aim of this study was to highlight if shift work with nights, as compared with day work only, is associated with risk factors predisposing nurses to poorer health conditions and lower job satisfaction.Methods: This cross-sectional study was conducted from June 1, 2015 to July 31, 2015 in 17 wards of a general hospital and a residential facility of a northern Italian city. This study involved 213 nurses working in rotating night shifts and 65 in day shifts. The instrument used for data collection was the “Standard Shift Work Index,” validated in Italian. Data were statistically analyzed.Results: The response rate was 86%. The nurses engaged in rotating night shifts were statistically significantly younger, more frequently single, and had Bachelors and Masters degrees in nursing. They reported the lowest mean score in the items of job satisfaction, quality and quantity of sleep, with more frequent chronic fatigue, psychological, and cardiovascular symptoms in comparison with the day shift workers, in a statistically significant way.Conclusion: Our results suggest that nurses with rotating night schedule need special attention due to the higher risk for both job dissatisfaction and undesirable health effects. Keywords: shift work, night work

  12. Ambulatory surgery with chloroprocaine spinal anesthesia: a review

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    Ghisi D

    2015-11-01

    Full Text Available Daniela Ghisi, Stefano Bonarelli Department of Anaesthesia and Postoperative Intensive Care, Istituto Ortopedico Rizzoli, Bologna, Italy Abstract: Spinal anesthesia is a reliable and safe technique for procedures of the lower extremities. Nevertheless, some of its characteristics may limit its use for ambulatory surgery, including delayed ambulation, risk of urinary retention, and pain after block regression. The current availability of short-acting local anesthetics has renewed interest for this technique also in the context of short- and ultra-short procedures. Chloroprocaine (CP is an amino-ester local anesthetic with a very short half-life. It was introduced and has been successfully used for spinal anesthesia since 1952. Sodium bisulfite was then added as a preservative after 1956. The drug was then abandoned in the 1980s for several reports of neurological deficits in patients receiving accidentally high doses of intrathecal CP during epidural labor analgesia. Animal studies have proven the safety of the preservative-free formulation, which has been extensively evaluated in volunteer studies as well as in clinical practice with a favorable profile in terms of both safety and efficacy. In comparison with bupivacaine, 2-chloroprocaine (2-CP showed faster offset times to end of anesthesia, unassisted ambulation, and discharge from hospital. These findings suggests that 2-CP may be a suitable alternative to low doses of long-acting local anesthetics in ambulatory surgery. Its safety profile also suggests that 2-CP could be a valid substitute for intrathecal short- and intermediate-acting local anesthetics, such as lidocaine and mepivacaine – often causes of transient neurological symptoms. In this context, literature suggests a dose ranging between 30 and 60 mg of 2-CP for procedures lasting 60 minutes or less, while 10 mg is considered the no-effect dose. The present review describes recent evidence about 2-CP as an anesthetic agent for

  13. Ganglion cell complex and retinal nerve fiber layer measured by fourier-domain optical coherence tomography for early detection of structural damage in patients with preperimetric glaucoma

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    Rolle T

    2011-07-01

    Full Text Available Teresa Rolle, Cristina Briamonte, Daniela Curto, Federico Maria GrignoloEye Clinic, Section of Ophthalmology, Department of Clinical Physiopathology, University of Torino, Torino, ItalyAims: To evaluate the capability of Fourier-domain optical coherence tomography (FD-OCT to detect structural damage in patients with preperimetric glaucoma.Methods: A total of 178 Caucasian subjects were enrolled in this cohort study: 116 preperimetric glaucoma patients and 52 healthy subjects. Using three-dimensional FD-OCT, the participants underwent imaging of the ganglion cell complex (GCC and the optic nerve head. Sensitivity, specificity, likelihood ratios, and predictive values were calculated for all parameters at the first and fifth percentiles. Areas under the curves (AUCs were generated for all parameters and were compared (Delong test. For both the GCC and the optic nerve head protocols, the OR logical disjunction (Boolean logic operator was calculated.Results: The AUCs didn’t significantly differ. Macular global loss volume had the largest AUC (0.81. Specificities were high at both the fifth and first percentiles (up to 97%, but sensitivities were low, especially at the first percentile (55%–27%.Conclusion: Macular and papillary diagnostic accuracies did not differ significantly based on the 95% confidence interval. The computation of the Boolean OR operator has been found to boost diagnostic accuracy. Using the software-provided classification, sensitivity and diagnostic accuracy were low for both the retinal nerve fiber layer and the GCC scans. FD-OCT does not seem to be decisive for early detection of structural damage in patients with no functional impairment. This suggests that there is a need for analysis software to be further refined to enhance glaucoma diagnostic capability.Keywords: OCT, RNFL, GCC, diagnostic accuracy 

  14. Някои особени лексеми в старобългарския превод на Иполитовото тълкувание на Книга на пророк Даниил

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    Иван [Ivan] И. [I.] Илиев [Iliev

    2016-10-01

    leksemy w starobułgarskim przekładzie Komentarzy do Księgi Proroka Daniela Hipolita Rzymskiego Przedmiotem artykułu jest słowiańska wersja Komentarzy do Księgi Proroka Daniela (Commentarii in Danielem, CPG 1873 autorstwa Hipolita Rzymskiego (ok. 170–235, najwcześniejszych i najbardziej wnikliwych komentarzy do tej starotestamentowej księgi. Zostały one napisane około 204 roku, a ich przekład na język starobułgarski sytuuje się wśród najstarszych dzieł literatury bułgarskiej. Wciąż dyskutowany jest czas jego powstania: od ostatnich dekad wieku IX do połowy X. Niektóre fakty językowe związane z Komentarzami były sporadycznie porównywane z częściowym przekładem Księgi Proroka Daniela, zawartym w paremejniku. Porównywano także słowiański przekład Komentarzy z tak zwaną Księgą Proroków Starego Testamentu wraz z komentarzami. Artykuł koncentruje się na rękopisie z 1519 roku (Nr 486 w Zbiorze z Biblioteki Wołokołamska, Rosyjska Biblioteka Państwowa, Moskwa, który śledzi tradycję wcześniejszych kopii i najdokładniej zachowuje zawartość Komentarzy. Oprócz ich morfologicznej specyfiki w tekście znajduje się wiele cech leksykalnych, które pomagają określić datę i miejsce powstania przekładu. Wśród nich znajdują się markery leksykalne, które zasługują na uwagę, gdyż prowadzą do ciekawych odkryć. Wiele leksemów zawartych w tekście odnosi się do wczesnych kodeksów i świadczy o starożytności przekładu. Niektóre charakterystyczne leksemy łączą się ze słowami użytymi w Codex Suprasliensis i Pierwszym Zborniku Cara Symeona (Izbornik, 1073 rok, co dowodzi, że Komentarze są jedną z najwcześniejszych przetłumaczonych prac w obrębie literatury starobułgarskiej.

  15. Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study

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    Buonocore D

    2012-10-01

    Full Text Available Daniela Buonocore,1 Angelo Lazzeretti,2 Pedro Tocabens,3 Vincenzo Nobile,4 Enza Cestone,4 Giada Santin,5 Maria G Bottone,5,6 Fulvio Marzatico11Laboratory of Pharmacobiochemistry, Nutrition and Nutraceutical of Wellness, Department of Biology and Biotechnology “L Spallanzani”, University of Pavia, Pavia, Italy; 2GMC Pharma SRL, Milan, Italy; 3Actafarma Laboratorios, Madrid, Spain; 4Farcoderm SRL European Network for Tests in Dermatology and Wellness, Pavia, 5Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology “L Spallanzani”, 6Institute of Molecular Biology CNR, Section of Histochemistry and Cytometry, University of Pavia, Pavia, ItalyBackground: Skin is constantly exposed to pro-oxidant environmental stress from several sources, including air pollutants, ultraviolet solar light, and chemical oxidants. Reactive oxygen species have been implicated in age-related skin disorders. Dietary bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health. The advantage of a nutritional administration route is that blood delivers nutraceutical bioactive compounds continuously to all skin compartments, ie, the epidermis, dermis, and subcutaneous fat. The purpose of this study was to evaluate the topical and systemic effects of a dietary supplement containing resveratrol and procyanidin on age-related alterations to the skin, the skin antioxidant pool, and systemic oxidative stress levels.Methods: An instrumental study was performed in 50 subjects (25 treated with supplements and 25 with placebo to identify clinical features induced by chronoaging or photoaging. Product efficacy was evaluated after 60 days of treatment in terms of in vivo and in situ skin hydration, elasticity, and skin roughness levels, systemic oxidative stress levels by plasmatic derivatives of reactive oxygen metabolites and oxyadsorbent tests, and extent of the skin antioxidant pool.Results: After 60 days of

  16. Educational interventions to empower nursing home residents: a systematic literature review

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    Schoberer D

    2016-09-01

    Full Text Available Daniela Schoberer,1 Helena Leino-Kilpi,2 Helga E Breimaier,1 Ruud JG Halfens,3 Christa Lohrmann1 1Institute of Nursing Science, Medical University of Graz, Graz, Austria; 2Turku University Hospital, University of Turku, Turku, Finland; 3Department of Health Services Research, School for Public Health and Primary Care (CAPHRI, Maastricht University, Maastricht, the Netherlands Purpose of the study: Health education is essential to improve health care behavior and self-management. However, educating frail, older nursing home residents about their health is challenging. Focusing on empowerment may be the key to educating nursing home residents effectively. This paper examines educational interventions that can be used to empower nursing home residents.Methods: A systematic literature search was performed of the databases PubMed, CINAHL, CENTRAL, PsycINFO, and Embase, screening for clinical trials that dealt with resident education and outcomes in terms of their ability to empower residents. An additional, manual search of the reference lists and searches with SIGLE and Google Scholar were conducted to identify gray literature. Two authors independently appraised the quality of the studies found and assigned levels to the evidence reported. The results of the studies were grouped according to their main empowering outcomes and described narratively.Results: Out of 427 identified articles, ten intervention studies that addressed the research question were identified. The main educational interventions used were group education sessions, motivational and encouragement strategies, goal setting with residents, and the development of plans to meet defined goals. Significant effects on self-efficacy and self-care behavior were reported as a result of the interventions, which included group education and individual counseling based on resident needs and preferences. In addition, self-care behavior was observed to significantly increase in response to

  17. gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins

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    Smaldone G

    2013-07-01

    Full Text Available Giovanni Smaldone,1,2 Annarita Falanga,3 Domenica Capasso,4 Daniela Guarnieri,5,6 Stefania Correale,1,7 Massimiliano Galdiero,8 Paolo A Netti,4 Massimo Zollo,9 Stefania Galdiero,1,2 Sonia Di Gaetano,1 Emilia Pedone1 1Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy; 2Department of Pharmacy and Interuniversity Research Center on Bioactive Peptides, Federico II University of Naples, Naples, Italy; 3Molecular Diagnostics and Pharmaceuticals Scarl, Naples, Italy; 4Special Center for Biotechnology, Federico II University of Naples, Naples, Italy; 5Center for Advanced Biomaterials for Health Care, Interdisciplinary Research Centre on Biomaterials, Italian Institute of Technology, Naples, Italy; 6Interdisciplinary Research Centre on Biomaterials, Federico II University of Naples, Naples, Italy; 7Kedrion S.p.A, Sant'antimo, Naples, Italy; 8Department of Experimental Medicine, Federico II University of Naples, Naples, Italy; 9CEINGE – Advanced Biotechnology Scarl, Naples, Italy Abstract: A genetically modified recombinant gH625-c-prune was prepared through conjugation of c-prune with gH625, a peptide encompassing 625–644 residues of the glycoprotein H of herpes simplex virus 1, which has been proved to possess the ability to carry cargo molecules across cell membranes. C-prune is the C-terminal domain of h-prune, overexpressed in breast, colorectal, and gastric cancers, interacting with multiple partners, and representing an ideal target for inhibition of cancer development. Its C-terminal domain results in an intrinsically disordered domain (IDD, and the peculiar properties of gH625 render it an optimal candidate to act as a carrier for this net negatively charged molecule by comparison with the positively charged TAT. A characterization of the recombinant gH625-c-prune fusion protein was conducted by biochemical, cellular biology and confocal microscopy means in comparison with TAT-c-prune. The results showed that

  18. Effects of Glycemic Level on Outcome of Patients with Traumatic Brain Injury: A Retrospective Cohort Study

    Science.gov (United States)

    Alvis-Miranda, Hernando Raphael; Navas-Marrugo, Sandy Zuleica; Velasquez-Loperena, Robert Andrés; Adie-Villafañe, Richard José; Velasquez-Loperena, Duffay; Castellar-Leones, Sandra Milena; Alcala- Cerra, Gabriel; Pulido-Gutiérrez, Juan Camilo; Rodríguez-Conde, Javier Ricardo; Moreno-Moreno, María Fernanda; M. Rubiano, Andrés; Moscote-Salazar, Luis Rafael

    2014-01-01

    Objective: To determine the effects of glycemic level on outcome patients with traumatic brain injury. Methods:  From September 2010 to December 2012, all medical records of adult patients with TBI admitted to the Emergency Room of Laura Daniela Clinic in Valledupar City, Colombia, South America were enrolled. Both genders between 18 and 85 years who referred during the first 48 hours after trauma, and their glucose level was determined in the first 24 hours of admission were included. Adults older than 85 years, with absence of Glasgow Coma Scale (GCS) score and a brain Computerized Tomography (CT) scans were excluded. The cut-off value was considered 200 mg/dL to define hyperglycemia. Final GCS, hospital admission duration and complications were compared between normoglycemic and hyperglycemic patients. Results: Totally 217 patients were identified with TBI. Considering exclusion criteria, 89 patients remained for analysis. The mean age was 43.0±19.6 years, the mean time of remission was 5.9±9.4 hours, the mean GCS on admission was 10.5±3.6 and the mean blood glucose level in the first 24 hours was 138.1±59.4 mg/dL. Hyperglycemia was present in 13.5% of patients. The most common lesions presented by patients with TBI were fractures (22.5%), hematoma (18.3%), cerebral edema (18.3%) and cerebral contusion (16.2%). Most of patients without a high glucose level at admission were managed only medically, whereas surgical treatment was more frequent in patients with hyperglycemia (p=0.042). Hyperglycemia was associated with higher complication (p=0.019) and mortality rate (p=0.039). GCS was negatively associated with on admission glucose level (r=0.11; p=0.46). Conclusion: Hyperglycemia in the first 24-hours of TBI is associated with higher rate of surgical intervention, higher complication and mortality rates. So hyperglycemia handling is critical to the outcome of patients with traumatic brain injury. PMID:27162868

  19. Ocean acidification and its impacts: an expert survey

    Science.gov (United States)

    Gattuso, J.; Mach, K.; Morgan, M. G.

    2011-12-01

    pertaining to policy and socio-economic impacts, for example on food security, were also relatively low. Thanks are due to the respondents: Andreas Andersson, James Barry, Jerry Blackford, Philip Boyd, Ken Caldeira, Long Cao, Sinead Collins, Sarah Cooley, Kim Currie, Allemand Denis, Brad deYoung, Andrew Dickson, Ken Drinkwater, Sam Dupont, Jonathan Erez, Richard Feely, Maoz Fine, Kunshan Gao, Marion Gehlen, Jason Hall-Spencer, Christoph Heinze, Ove Hoegh-Guldberg, Gretchen Hofmann, Roberto Iglesias-Prieto, Maria Debora Iglesias-Rodriguez, Akio Ishida, Masao Ishii, Atsushi Ishimatsu, Haruko Kurihara, Kitack Lee, Su Mei Liu, Salvador Lluch-Cota, Jeremy T. Mathis, Ben McNeil, Philip Munday, John Pandolfi, Gian-Kasper Plattner, Alexander Polonsky, Hans-Otto Pörtner, Ulf Riebesell, Rongshuo, Chris Sabine, Daniela Schmidt, Brad Seibel, Yoshihisa Shirayama, Atsushi Suzuki, Carol Turley, Nicola Wannicke, Poh Poh Wong, Michiyo Yamamoto-Kawai and Peter Zavialov.

  20. User preference for a portable syringe pump for iloprost infusion

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    Laria A

    2015-05-01

    Full Text Available Antonella Laria,1 Alfredo Maria Lurati,1 Katia Angela Re,1 Maria Grazia Marrazza,1 Daniela Mazzocchi,1 Alberto Farina,2 Magda Scarpellini,1 1Department of Rheumatology, Fornaroli Hospital, Magenta, Milan, Italy; 2Medical Affairs Department, Italfarmaco S.p.A., Cinisello Balsamo, Milan, Italy Purpose: Administration of intravenous iloprost – a first-line European League Against Rheumatism (EULAR-recommended choice for the treatment of scleroderma (SSc-related digital vasculopathy – requires repeated treatment cycles of 6 hours per day in a hospital setting. During the infusion, patient mobility is considerably restricted due to the size and fixity of traditional syringe pumps. The aim of this study was to evaluate the satisfaction level of patients and nurses, after the introduction of a new portable syringe pump (Infonde®, Italfarmaco S.p.A., Milan, Italy at the Department of Rheumatology, Magenta Hospital, Milan, Italy. Patients and methods: Thirty-four consecutive SSc patients receiving stable therapy with iloprost, previously administered with a fixed pump, were treated using the portable Infonde® pump. Patients (n=34 and nurses (n=4 were asked to answer a nine- and six-item questionnaire, respectively, to assess the satisfaction of the administration comparing the new device versus the previous one. The health care staff of the ward developed the questionnaire, and the response scores ranged from 0 (fixed device better to 10 (portable device better; thus a score >5 indicates a preference for Infonde®. Results: Patients' answers indicated a preference towards the new portable syringe pump, versus the previous fixed pump. Questionnaires administered to patients generated a total of 306 responses, with over 95% of the responses in the range 8–10, of which 89% had a score equal to 10. The responses of nurses showed a score equal to 10 in 100% cases. No significant adverse events were recorded, indicating no change in the tolerability

  1. Künstlerisch geleitete Medienbildung mit Portfolios: Potenziale für Jugendliche in berufsvorbereitenden Bildungsmaßnahmen

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    Daniela Reimann

    2014-06-01

    Full Text Available Die pädagogische Zielgruppe des BMBF-Forschungsprojekts "MediaArt@Edu" (Leitung: Dr. Daniela Reimann, Wiss. Mitarbeiterin: Simone Bekk sind TeilnehmerInnen außerschulischer berufsvorbereitender Bildungsmaßnahmen, die im Rahmen von künstlerischen Workshops Medienprojekte am ZKM realisieren, die Gestaltungsprozesse mittels Projektportfolio visualisieren und – betreut von studentischen Mentoren – reflektieren. Die Jugendlichen sollen gestalterisch und spielerisch an Medientechnologien herangeführt werden, um eigene berufsübergreifende Potenziale entdecken zu können. Das KIT kooperiert dabei mit dem Zentrum für Kunst und Medientechnologie und der Arbeitsagentur Karlsruhe. Es werden Workshops zu unterschiedlichen thematischen Medienmodulen durchgeführt und evaluiert, wie z. B. Roboter_Gestalten, Licht_Gestalten, GamesLab, Sound und Smart Textile (Wearables. Ziel des Vorhabens ist es, ein neues Konzept digitaler Medienbildung mit Lernprozessbegleitung durch Studierende zu entwickeln, welches künstlerische Vermittlungsformen, interaktive Medien und Kunst einbezieht und das den Voraussetzungen, Bedürfnissen und Entwicklungsperspektiven von Jugendlichen in der Berufsvorbereitung und -orientierung besser als bislang entspricht und zur ihrer individuellen Berufsbiografiegestaltung beiträgt. Im vorliegenden Artikel wird der mediendidaktische Ansatz und das kunstpädagogische Konzept des Projekts anhand des Beispielmoduls "Licht-Objekte gestalten" vorgestellt und anhand von Beispielen aus der Projektarbeit veranschaulicht. The target group of the research project "MediaArt@Edu" (Acronym are paticipants of vocational preparation measures, who develop media projects in the context of artistic workshops at ZKM. They visualize the design processes using a project portfolio, reflected with student mentors.The young people experience media technologies through design, play in order to realize their own potentials and key skills, necessary across

  2. Interfacial Au nanoparticle decoration of a disulfide modified G-wire.

    Science.gov (United States)

    Goblirsch, Brandon R; Kalb, Evan M; Marsh, Thomas C

    2017-05-01

    The guanine-rich oligonucleotide (GRO), dGGGGTTGGGG (G4T2G4), has the capacity to form a linear supramolecular polymer known as a G-wire. Individual nucleotides of the component GROs can be functionally modified to serve as site-specific attachment points in the G-wire while not interfering with its self-assembling properties. An amine linker modification to an internal thymine base of the GRO, denoted G4TT*G4, serves as a chemically versatile attachment site. In this work, addition of an alkyl disulfide to G4TT*G4 produces the GRO G4TT(d)G4 enabling binding to gold nanoparticles via place exchange chemistry. G-wires assembled by combining G4T2G4 and G4TT(d)G4 were stably maintained in an aqueous environment. Disulfide modified G-wires (DS_G-wire) were then covered with dodecanethiol capped gold nanoparticles in an organic solvent via an interfacial place exchange reaction. Tapping Mode AFM and TEM were used to image G-wires decorated with gold nanoparticles. The specificity of the interfacial place exchange reaction was measured using a fluorometric dye displacement from the gold nanoparticles. The results show that a two component DS_G-wire with an amphipathic tether readily self-assemble as shown by PAGE and TM-AFM. The amphipathic disulfide moiety of DS_G-wires facilitates place exchange chemistry with alkylthiol protected Au nanoparticles across an aqueous-organic interface. Interfacial place exchange is an effective strategy for decorating DS_G-wires with Au nanoparticles. The use of modified G-wire self-assembly combined with a high degree of nanoparticle binding specificity presents another strategy for the use of G-wires as a rigid one-dimensional molecular scaffold with potential applications in nanoscale device construction. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition

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    Perna G

    2011-10-01

    Full Text Available Giampaolo Perna1-3, Silvia Daccò2, Roberta Menotti2, Daniela Caldirola21Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, the Netherlands; 2Department of Clinical Neuroscience, San Benedetto Hospital, Hermanas Hospitalarias, Albese con Cassano, Como, Italy; 3Department of Psychiatry and Behavioral Sciences, Leonard M Miller School of Medicine, University of Miami, Miami, FL, USABackground: Although there are controversial issues (the "American view" and the "European view" regarding the construct and definition of agoraphobia (AG, this syndrome is well recognized and it is a burden in the lives of millions of people worldwide. To better clarify the role of drug therapy in AG, the authors summarized and discussed recent evidence on pharmacological treatments, based on clinical trials available from 2000, with the aim of highlighting pharmacotherapies that may improve this complex syndrome.Methods: A systematic review of the literature regarding the pharmacological treatment of AG was carried out using MEDLINE, EBSCO, and Cochrane databases, with keywords individuated by MeSH research. Only randomized, placebo-controlled studies or comparative clinical trials were included.Results: After selection, 25 studies were included. All the selected studies included patients with AG associated with panic disorder. Effective compounds included selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, selective noradrenergic reuptake inhibitors, and benzodiazepines. Paroxetine, sertraline, citalopram, escitalopram, and clomipramine showed the most consistent results, while fluvoxamine, fluoxetine, and imipramine showed limited efficacy. Preliminary results suggested the potential efficacy of inositol; D-cycloserine showed mixed results for its ability to improve the outcome of exposure-based cognitive behavioral therapy

  4. Improvement of HbA1c and stable weight loss 2 years after an outpatient treatment and teaching program for patients with type 2 diabetes without insulin therapy based on urine glucose self-monitoring

    Directory of Open Access Journals (Sweden)

    Müller N

    2012-03-01

    Full Text Available Nicolle Müller1, Daniela Stengel2, Christof Kloos1, Michael Ristow2, Gunter Wolf1, Ulrich A Müller11University Hospital of Jena, Department of Internal Medicine III, Jena, Germany; 2Friedrich-Schiller-University Jena, Institute of Nutrition, Department of Human Nutrition, Jena, GermanyObjective: Long-term outcomes after participation in a structured diabetes treatment and teaching program (DTTP for patients with diabetes without insulin use, primarily based upon postprandial urine glucose self-monitoring (UGSM.Methods: A total of 126 patients took part in the DTTP in a university outpatient department in 2004–2005. We re-evaluated 119 (94.4% at baseline and at 6 months, 12 months, and 24 months. Hemoglobin A1c (HbA1c was DCCT adjusted.Results: HbA1c decreased significantly 6 months after education from 7.33% (±1.59% to 6.89% (±0.98%; P = 0.001 versus baseline and was maintained for up to 12 months (7.02% ± 1.07%; P = 0.017 versus baseline as well as up to 24 months (6.96% ± 1.06%; P = 0.005 versus baseline. Weight decreased from 92.5 kg at baseline to 90.3 kg at 24 months (P = 0.014. A total of 36.5% of patients not on insulin therapy preferred UGSM, whereas 23.5% preferred blood glucose monitoring, at 24 months. Glucose control was similar in both groups at 24 months (HbA1c UGSM 7.03 versus blood glucose monitoring 6.97%; P = 0.807.Conclusion: Participation in the DTTP resulted in long-term behavior modification. HbA1c of patients without insulin met the target 24 months after the DTTP, irrespective of the type of glucose self-monitoring.Keywords: diabetes mellitus type 2, treatment and teaching program, patient education, HbA1c, body weight

  5. Targeting PD-1/PD-L1 in lung cancer: current perspectives

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    González-Cao M

    2015-07-01

    Full Text Available María González-Cao,1 Niki Karachaliou,1 Santiago Viteri,1 Daniela Morales-Espinosa,1 Cristina Teixidó,2 Jesús Sánchez Ruiz,3 Miquel Ángel Molina-Vila,2 Mariacarmela Santarpia,4 Rafael Rosell1,2,5,61Translational Cancer Research Unit, Instituto Oncológico Dr Rosell, Quirón Dexeus University Hospital, Barcelona, Spain; 2Pangaea Biotech SL, Barcelona, Spain; 3Centro Nacional de Investigación Oncología (CNIO, Madrid, Spain; 4Medical Oncology Unit, Human Pathology Department, University of Messina, Messina, Italy; 5Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology, Germans Trias i Pujol Health Sciences Institute and Hospital, Campus Can Ruti, Badalona, Barcelona, Spain; 6Fundación Molecular Oncology Research, Barcelona, SpainAbstract: Increased understanding of tumor immunology has led to the development of effective immunotherapy treatments. One of the most important advances in this field has been due to pharmacological design of antibodies against immune checkpoint inhibitors. Anti-PD-1/PD-L1 antibodies are currently in advanced phases of clinical development for several tumors, including lung cancer. Results from Phase I–III trials with anti-PD-1/PD-L1 antibodies in non-small-cell lung cancer have demonstrated response rates of around 20% (range, 16%–50%. More importantly, responses are long-lasting (median duration of response, 18 months and fast (50% of responses are detected at time of first tumor evaluation with very low grade 3–4 toxicity (less than 5%. Recently, the anti-PD-1 antibody pembrolizumab received US Food and Drug Administration (FDA breakthrough therapy designation for treatment of non-small-cell lung cancer, supported by data from a Phase Ib trial. Another anti-PD-1 antibody, nivolumab, has also been approved for lung cancer based on survival advantage demonstrated in recently released data from a Phase III trial in squamous cell lung cancer.Keywords: immunotherapy, immunoncology

  6. Inhalation errors due to device switch in patients with chronic obstructive pulmonary disease and asthma: critical health and economic issues

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    Roggeri A

    2016-03-01

    Full Text Available Alessandro Roggeri,1 Claudio Micheletto,2 Daniela Paola Roggeri1 1ProCure Solutions, Nembro, Bergamo, Italy, 2Respiratory Unit, Mater Salutis Hospital, Legnago, Verona, Italy Background: Different inhalation devices are characterized by different techniques of use. The untrained switching of device in chronic obstructive pulmonary disease (COPD and asthma patients may be associated with inadequate inhalation technique and, consequently, could lead to a reduction in adherence to treatment and limit control of the disease. The aim of this analysis was to estimate the potential economic impact related to errors in inhalation in patients switching device without adequate training. Methods: An Italian real-practice study conducted in patients affected by COPD and asthma has shown an increase in health care resource consumption associated with misuse of inhalers. Particularly, significantly higher rates of hospitalizations, emergency room visits (ER, and pharmacological treatments (steroids and antimicrobials were observed. In this analysis, those differences in resource consumption were monetized considering the Italian National Health Service (INHS perspective. Results: Comparing a hypothetical cohort of 100 COPD patients with at least a critical error in inhalation vs 100 COPD patients without errors in inhalation, a yearly excess of 11.5 hospitalizations, 13 ER visits, 19.5 antimicrobial courses, and 47 corticosteroid courses for the first population were revealed. In the same way, considering 100 asthma patients with at least a critical error in inhalation vs 100 asthma patients without errors in inhalation, the first population is associated with a yearly excess of 19 hospitalizations, 26.5 ER visits, 4.5 antimicrobial courses, and 21.5 corticosteroid courses. These differences in resource consumption could be associated with an increase in health care expenditure for INHS, due to inhalation errors, of €23,444/yr in COPD and €44,104/yr in

  7. Effects of Glycemic Level on Outcome of Patients with Traumatic Brain Injury: A Retrospective Cohort Study

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    Hernando Raphael Alvis-Miranda

    2014-04-01

    Full Text Available Objective: To determine the effects of glycemic level on outcome patients with traumatic brain injury. Methods: From September 2010 to December 2012, all medical records of adult patients with TBI admitted to the Emergency Room of Laura Daniela Clinic in Valledupar City, Colombia, South America were enrolled. Both genders between 18 and 85 years who referred during the first 48 hours after trauma, and their glucose level was determined in the first 24 hours of admission were included. Adults older than 85 years, with absence of Glasgow Coma Scale (GCS score and a brain Computerized Tomography (CT scans were excluded. The cut-off value was considered 200 mg/dL to define hyperglycemia. Final GCS, hospital admission duration and complications were compared between normoglycemic and hyperglycemic patients. Results: Totally 217 patients were identified with TBI. Considering exclusion criteria, 89 patients remained for analysis. The mean age was 43.0±19.6 years, the mean time of remission was 5.9±9.4 hours, the mean GCS on admission was 10.5±3.6 and the mean blood glucose level in the first 24 hours was 138.1±59.4 mg/dL. Hyperglycemia was present in 13.5% of patients. The most common lesions presented by patients with TBI were fractures (22.5%, hematoma (18.3%, cerebral edema (18.3% and cerebral contusion (16.2%. Most of patients without a high glucose level at admission were managed only medically, whereas surgical treatment was more frequent in patients with hyperglycemia (p=0.042. Hyperglycemia was associated with higher complication (p=0.019 and mortality rate (p=0.039. GCS was negatively associated with on admission glucose level (r=0.11; p=0.46. Conclusion: Hyperglycemia in the first 24-hours of TBI is associated with higher rate of surgical intervention, higher complication and mortality rates. So hyperglycemia handling is critical to the outcome of patients with traumatic brain injury.

  8. Adherence to oral anticoagulant therapy in secondary stroke prevention – impact of the novel oral anticoagulants

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    Luger S

    2015-11-01

    Full Text Available Sebastian Luger,1 Carina Hohmann,2 Daniela Niemann,1 Peter Kraft,3 Ignaz Gunreben,3 Tobias Neumann-Haefelin,2 Christoph Kleinschnitz,3 Helmuth Steinmetz,1 Christian Foerch,1 Waltraud Pfeilschifter1 1Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, 2Department of Neurology, Klinikum Fulda gAG, Fulda, 3Department of Neurology, University Hospital Würzburg, Würzburg, Germany Background: Oral anticoagulant therapy (OAT potently prevents strokes in patients with atrial fibrillation. Vitamin K antagonists (VKA have been the standard of care for long-term OAT for decades, but non-VKA oral anticoagulants (NOAC have recently been approved for this indication, and raised many questions, among them their influence on medication adherence. We assessed adherence to VKA and NOAC in secondary stroke prevention. Methods: All patients treated from October 2011 to September 2012 for ischemic stroke or transient ischemic attack with a subsequent indication for OAT, at three academic hospitals were entered into a prospective registry, and baseline data and antithrombotic treatment at discharge were recorded. At the 1-year follow-up, we assessed the adherence to different OAT strategies and patients’ adherence to their respective OAT. We noted OAT changes, reasons to change treatment, and factors that influence persistence to the prescribed OAT. Results: In patients discharged on OAT, we achieved a fatality corrected response rate of 73.3% (n=209. A total of 92% of these patients received OAT at the 1-year follow-up. We observed good adherence to both VKA and NOAC (VKA, 80.9%; NOAC, 74.8%; P=0.243 with a statistically nonsignificant tendency toward a weaker adherence to dabigatran. Disability at 1-year follow-up was an independent predictor of lower adherence to any OAT after multivariate analysis, whereas the choice of OAT did not have a relevant influence. Conclusion: One-year adherence to OAT after stroke is strong (>90% and patients

  9. Increased leptin/leptin receptor pathway affects systemic and airway inflammation in COPD former smokers

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    Bruno A

    2011-05-01

    Full Text Available Andreina Bruno1, Marinella Alessi2, Simona Soresi2, Anna Bonanno1, Loredana Riccobono1, Angela Marina Montalbano1, Giusy Daniela Albano1, Mark Gjomarkaj1, Mirella Profita11Institute of Biomedicine and Molecular Immunology, Italian National Research Council, Palermo, Italy; 2Dipartimento Biomedico di Biomedicina Interna e Specialistica, University Palermo, ItalyBackground: Leptin, a hormone produced mainly by adipose tissue, regulates food intake and energy expenditure. It is involved in inflammatory diseases such as chronic obstructive pulmonary disease (COPD and its deficiency is associated with increased susceptibility to the infection. The leptin receptor is expressed in the lung and in the neutrophils.Methods: We measured the levels of leptin, tumor necrosis factor alpha (TNF-a and soluble form of intercellular adhesion molecule-1 (sICAM-1 in sputum and plasma from 27 smoker and former smoker patients with stable COPD using ELISA methods. Further we analyzed leptin and its receptor expression in sputum cells from 16 COPD patients using immunocytochemistry.Results: In plasma of COPD patients, leptin was inversely correlated with TNF-a and positively correlated with the patient weight, whereas the levels of sICAM-1 were positively correlated with TNF-a. In sputum of COPD patients leptin levels were correlated with forced expiratory volume in 1 second/forced vitality capacity. Additionally, increased levels of sputum leptin and TNF-a were observed in COPD former smokers rather than smokers. Further the expression of leptin receptor in sputum neutrophils was significantly higher in COPD former smokers than in smokers, and the expression of leptin and its receptor was positively correlated in neutrophils of COPD former smokers.Conclusion: Our findings suggest a role of leptin in the local and systemic inflammation of COPD and, taking into account the involvement of neutrophils in this inflammatory disease, describe a novel aspect of the leptin

  10. Predictors of pneumothorax following endoscopic valve therapy in patients with severe emphysema

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    Gompelmann D

    2016-08-01

    Full Text Available Daniela Gompelmann,1,2,* Hyun-ju Lim,3,4,* Ralf Eberhardt,1,2 Vasiliki Gerovasili,5 Felix JF Herth,1,2 Claus Peter Heussel,2–4 Monika Eichinger3,4 1Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, 3Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, 4Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany; 5First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece *These authors contributed equally to this work Background: Endoscopic valve implantation is an effective treatment for patients with advanced emphysema. Despite the minimally invasive procedure, valve placement is associated with risks, the most common of which is pneumothorax. This study was designed to identify predictors of pneumothorax following endoscopic valve implantation. Methods: Preinterventional clinical measures (vital capacity, forced expiratory volume in 1 second, residual volume, total lung capacity, 6-minute walk test, qualitative computed tomography (CT parameters (fissure integrity, blebs/bulla, subpleural nodules, pleural adhesions, partial atelectasis, fibrotic bands, emphysema type and quantitative CT parameters (volume and low attenuation volume of the target lobe and the ipsilateral untreated lobe, target air trapping, ipsilateral lobe volume/hemithorax volume, collapsibility of the target lobe and the ipsilateral untreated lobe were retrospectively evaluated in patients who underwent endoscopic valve placement (n=129. Regression analysis was performed to compare those who developed pneumothorax following valve therapy (n=46 with those who developed target lobe volume reduction without pneumothorax (n=83. Finding: Low attenuation volume% of ipsilateral untreated lobe (odds ratio [OR] =1.08, P=0.001, ipsilateral

  11. Emergency thoracic ultrasound and clinical risk management

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    Interrigi MC

    2017-02-01

    Full Text Available Maria Concetta Interrigi,1 Francesca M Trovato,2,3 Daniela Catalano,3,4 Guglielmo M Trovato3,5 1Accident and Emergency Department, Ospedale Cannizzaro, Catania, 2Accident and Emergency Department, Ospedale Civile, Ragusa, 3Department of Clinical and Experimental Medicine, The School of Medicine, University of Catania, 4Postgraduate School of Clinical Ultrasound, Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Policlinico, University of Catania, 5Postgraduate School of e-Learning and ICT in Health Sciences, The School of Medicine, University of Catania, Catania, Italy Purpose: Thoracic ultrasound (TUS has been proposed as an easy-option replacement for chest X-ray (CXR in emergency diagnosis of pneumonia, pleural effusion, and pneumothorax. We investigated CXR unforeseen diagnosis, subsequently investigated by TUS, considering its usefulness in clinical risk assessment and management and also assessing the sustainability of telementoring. Patients and methods: This observational report includes a period of 6 months with proactive concurrent adjunctive TUS diagnosis telementoring, which was done using freely available smartphone applications for transfer of images and movies. Results: Three hundred and seventy emergency TUS scans (excluding trauma patients were performed and telementored. In 310 cases, no significant chest pathology was detected either by CXR, TUS, or the subsequent work-up; in 24 patients, there was full concordance between TUS and CXR (ten isolated pleural effusion; eleven pleural effusion with lung consolidations; and three lung consolidation without pleural effusion; in ten patients with lung consolidations, abnormalities identified by CXR were not detected by TUS. In 26 patients, only TUS diagnosis criteria of disease were present: in 19 patients, CXR was not diagnostic, ie, substantially negative, but TUS detected these conditions correctly, and these were later confirmed by computed

  12. Bronchodilator efficacy of extrafine glycopyrronium bromide: the Glyco 2 study

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    Singh D

    2017-07-01

    Full Text Available Dave Singh,1 Mario Scuri,2 Sara Collarini,2 Stefano Vezzoli,2 Fabrizia Mariotti,2 Annamaria Muraro,2 Daniela Acerbi2 1Medicines Evaluation, University Of Manchester, University Hospital of South Manchester, Manchester, UK; 2Global Clinical Development, Chiesi Farmaceutici SpA, Parma, Italy Abstract: An extrafine formulation of the long-acting muscarinic antagonist glycopyrronium bromide (GB is in development for chronic obstructive pulmonary disease (COPD, in combination with beclometasone dipropionate and formoterol fumarate – a “fixed triple”. This two-part study was randomized, double blind, placebo controlled in patients with moderate-to-severe COPD: Part 1: single-dose escalation, GB 12.5, 25, 50, 100 or 200 µg versus placebo; Part 2: repeat-dose (7-day, four-period crossover, GB 12.5, 25 or 50 µg twice daily (BID versus placebo, with an open-label extension in which all patients received tiotropium 18 µg once daily. On the morning of Day 8 in all five periods, patients also received formoterol 12 µg. In study Part 1, 27 patients were recruited. All GB doses significantly increased from baseline forced expiratory volume in 1 second (FEV1 area under the curve (AUC0–12h and peak FEV1, with a trend toward greater efficacy with higher GB dose. All adverse events were mild–moderate in severity, with a lower incidence with GB than placebo and no evidence of a dose–response relationship. In study Part 2, of 38 patients recruited, 34 completed the study. Adjusted mean differences from placebo in 12 h trough FEV1 on Day 7 (primary were 115, 142 and 136 mL for GB 12.5, 25 and 50 µg BID, respectively (all P<0.001. GB 25 and 50 µg BID were superior (P<0.05 to GB 12.5 µg BID for pre-dose morning FEV1 on Day 8. For this endpoint, GB 25 and 50 µg BID were also superior to tiotropium. Compared with Day 7, addition of formoterol significantly increased Day 8 FEV1 peak and AUC0–12h with all GB doses and placebo (all P<0.001. All

  13. Long-term benefit of sunitinib in patients with metastatic renal cell carcinoma in Latin America: retrospective analysis of patient clinical characteristics

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    Smaletz O

    2016-11-01

    Full Text Available Oren Smaletz,1 Matias Chacón,2 Ludmila de Oliveira Koch,1 Daniela R de Carvalho Rocha,1 Fernanda C Cardoso1 1Department of Oncology, Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Medical Oncology Department, Alexander Fleming Institute, Buenos Aires, Argentina Objective: To describe the clinical characteristics of Latin American patients with metastatic renal cell carcinoma (mRCC who experienced a progression-free survival (PFS for at least 15 months following treatment with sunitinib. Patients and methods: In this retrospective analysis, mRCC patients in two institutions in Latin America received sunitinib at a starting dose of either 50 mg/day for 4 weeks followed by 2 weeks off treatment (Schedule 4/2 in repeated 6-week cycles or sunitinib 37.5 mg on a continuous daily dosing schedule. Clinical characteristics, tolerability, and PFS data were collected. Results: Twenty-nine patients with long-term clinical benefit from sunitinib were identified between September 2005 and August 2009. Median PFS was 23 months (range: 15–54 months. Two of the 29 patients with prolonged PFS achieved a complete response and additional eleven had a partial response. Most patients were aged <60 years, had good performance status, favorable or intermediate Memorial Sloan Kettering Cancer Center prognostic risk, and disease limited to one or two sites. Dose reduction was necessary in all patients who started sunitinib at 50 mg/day administered on Schedule 4/2. Adverse events leading to dose reduction included grade 3 hand–foot syndrome, mucositis, fatigue, and hypertension. At the time of data cutoff, four patients were still receiving sunitinib treatment. Conclusion: Extended PFS can be achieved in Latin American patients with mRCC treated with sunitinib. Although the small sample size and retrospective nature of this evaluation preclude the identification of pretreatment predictive factors contributing to this benefit, the current analysis warrants

  14. The role of duloxetine in the treatment of anxiety disorders

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    Domenico De Berardis

    2008-07-01

    Full Text Available Domenico De Berardis1,2,3, Nicola Serroni2, Alessandro Carano1,4, Marco Scali1,4, Alessandro Valchera5, Daniela Campanella1,2, Alessandro D’Albenzio1, Berardo Di Giuseppe2, Francesco Saverio Moschetta2, Rosa Maria Salerno1, Filippo Maria Ferro11Department of Oncology and Neurosciences, Institute of Psychiatry, “G. D’Annunzio” University of Chieti, Italy; 2National Health Service, Department of Mental Health, SPDC Teramo, Italy; 3ITAB, Institute for Advanced Biomedical Technologies, “G. D’Annunzio” University Foundation, Chieti, Italy; 4National Health Service, Department of Mental Health, ASUR Marche 8, Civitanova Marche, Italy; 5Division of Psychiatry, “S. Giuseppe” Clinic, Ascoli Piceno, ItalyAbstract: Anxiety disorders (ADs are the most common type of psychiatric disorders, with a mean incidence of 18.1% and a lifetime prevalence of 28.8%. Pharmacologic options studied for treating ADs may include benzodiazepines, tricyclic antidepressants (TCA, selective serotonin reuptake inhibitors (SSRIs, noradrenergic and specific serotonergic drug (NaSSA and dual-reuptake inhibitors of serotonin and norepinephrine (SNRIs. In this context, the development of SNRIs (venlafaxine and duloxetine has been particularly useful. As a dual-acting intervention that targets two neurotransmitter systems, these medications would appePar promising for the treatment of ADs. The purpose of this review was to elucidate current facts and views about the role of duloxetine in the treatment of ADs. In February 2007, duloxetine was approved by FDA for the treatment of generalized anxiety disorder (GAD. The results of trials evaluating the use duloxetine in the treatment of GAD are supportive on its efficacy even if further studies on long-term use are needed. Apart from some interesting case reports, no large studies are, to date, present in literature about duloxetine and other ADs such as panic disorder, social anxiety disorder, obsessive

  15. Investigating patient expectations and treatment outcome in a chronic low back pain population

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    Sanderson KB

    2012-01-01

    Full Text Available Kristen B Sanderson1, Daniela Roditi1, Steven Z George2, James W Atchison3, Evangelia Banou4, Michael E Robinson11Department of Clinical Health Psychology, 2Department of Physical Therapy, 3Department of Orthopedics and Rehabilitation, University of Florida, Gainesville, FL, USA; 4Chronic Pain Rehabilitation Program, James A Haley VA Hospital, Tampa, FL, USAObjective: This study aimed to measure the outcomes that patients consider clinically meaningful across four treatment domains – (1 pain, (2 fatigue, (3 emotional distress, and (4 level of interference – and determine if patients met their own success criteria. Additionally, the role of expectations in treatment outcome was examined. This study also aimed to determine how change in levels of pain, fatigue, disability, and level of interference varied according to the type of treatment delivered to participants.Patients: Forty-seven chronic low back pain patients were recruited from university-affiliated pain clinics.Design: The study design was longitudinal, consisting of two randomly assigned treatment conditions. The first treatment condition used opioid medication only and the second used both opioid medication and brief cognitive behavioral therapy. Pre- and post-treatment assessments were conducted, which occurred approximately 3 months after the initiation of treatment.Outcome measures: A patient-centered outcomes questionnaire was completed by participants at both pre- and post-treatment assessment.Results: Results suggest that patients did not meet their own success criteria in treatment across any of the four domains. There was a significant main effect of time for level of pain indicating that both treatment groups had a decrease in their level of pain at post-treatment, F(1, 45 = 11.98, P < 0.001. There was a significant main effect of time for level of interference domain indicating that both groups experienced a reduction in the level of pain-related interference with daily

  16. Incidence and costs of hip fractures vs strokes and acute myocardial infarction in Italy: comparative analysis based on national hospitalization records

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    Piscitelli P

    2012-12-01

    Full Text Available Prisco Piscitelli,1,2 Giovanni Iolascon,3 Alberto Argentiero,2 Giovanna Chitano,2 Cosimo Neglia,2 Gemma Marcucci,1 Manuela Pulimeno,2 Marco Benvenuto,2 Santa Mundi,2 Valentina Marzo,2 Daniela Donato,4 Angelo Baggiani,4 Alberto Migliore,5 Mauro Granata,6 Francesca Gimigliano,3 Raffaele Di Blasio,7 Alessandra Gimigliano,3 Lorenzo Renzulli,7 Maria Luisa Brandi,1 Alessandro Distante,2,4 Raffaele Gimigliano3,71University of Florence, Florence Italy; 2ISBEM Research Centre, Brindisi, Italy; 3Second University of Naples, Naples, Italy; 4University of Pisa, Pisa, Italy; 5Fatebenefratelli St Peter’s Hospital, Rome, Italy; 6St Filippo Neri Hospital, Rome, Italy; 7Casa di Cura Santa Maria del Pozzo, Somma Vesuviana, ItalyObjectives: As osteoporotic fractures are becoming a major health care problem in countries characterized by an increasing number of older adults, in this study we aimed to compare the incidence and costs of hip fragility fractures in Italian elderly people versus those of major cardiovascular diseases (strokes and acute myocardial infarctions [AMI] occurring in the whole adult population.Methods: We analyzed hospitalization records maintained at the national level by the Italian Ministry of Health for the diagnosis of hip fractures (ICD-9-CM codes 820–821, AMI (code 410, hemorrhagic (codes 430, 431, 432 and ischemic strokes (codes 433–434, and TIA (code 435 between 2001–2005. Cost analyses were based on diagnosis-related groups.Results: The incidence of hip fractures in elderly people has increased (+12.9% between 2001 and 2005, as well as that of AMI (+20.2% and strokes (hemorrhagic: +9.6%; ischemic: +14.7 occurring in the whole adult population; conversely, hospitalization due to TIA decreased by a rate of 13.6% between 2001 and 2005. In 2005, the hospital costs across the national health care system that were associated with hip fragility fractures in the elderly were comparable to those of strokes (both hemorrhagic and

  17. Imagining Geographies, Mapping Identities

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    Matthew Graves

    2015-03-01

    Full Text Available The ambition of this issue of Portal is to reach across the methodological boundaries of history, politics, literature and geography to apply their complementary perspectives to the study of identity and its relation to space and place, an aim that involves attempting to identify the many different ways the notoriously slippery concepts of identity and geography may intersect. For this issue we have selected articles that cast a fresh perspective on two areas where identity and geography intersect: the construction of identity through the imaginative recreation of place in literature: Mapping Literary Spaces; and the study of the shifting relationships of centre and periphery, exclusion and inclusion in urban settings and geopolitical confrontations: Social and Political Peripheries. Gerard Toal has written that geography is not a noun but a verb: it does not describe what space is but studies what we do with space, imaginatively and politically. The articles in this issue illustrate the exercise of the literary and political imagination and the role of materiality and memory in the creation of geographic representation. They show too a new awareness of the centrality of space in the constitution of identities, and the need for a new geocritical reading of its discourse, as the interrelations of place and community are played out on the many scales of social and political life, from the local to the global.   The special issue is organised thus: Introduction Matthew Graves (Aix-Marseille University & Liz Rechniewski (Sydney University: “Imagining Geographies, Mapping Identities.” I. Mapping Literary Spaces - Isabelle Avila (University of Paris XIII, "Les Cartes de l'Afrique au XIXe siècle et Joseph Conrad : Perceptions d'une Révolution Cartographique." - Daniela Rogobete (University of Craiova, "Global vs Glocal: Dimensions of the post-1981 Indian English Novel." II. Social and Political Peripheries - Elizabeth Rechniewski (Sydney

  18. Economic benefit of a polyacrylate-based hydrogel compared to an amorphous hydrogel in wound bed preparation of venous leg ulcers

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    Kaspar D

    2015-04-01

    Full Text Available Daniela Kaspar,1 Jörg Linder,1 Petra Zöllner,1 Ulrich Simon,2 Hans Smola1,31Medical Competence Centre, Paul Hartmann AG, Heidenheim, Germany; 2Scientific Computing Centre, Ulm University, Ulm, Germany; 3Department of Dermatology, University of Cologne, Cologne, GermanyObjective: To assess the cost-effectiveness of a polyacrylate (PA-based hydrogel compared to an amorphous hydrogel in wound bed preparation for venous leg ulcers.Method: A cost-effectiveness analysis was undertaken alongside a multicenter, randomized controlled trial performed in France. A total of 75 patients with venous leg ulcers extensively covered with fibrin and necrotic tissue were randomized to a PA-containing hydrogel or an amorphous hydrogel. Wounds were treated for 14 days and costs were estimated from the German payer's perspective. Medical costs included study treatment, wound treatment supply, and labor time. The clinical benefit was expressed as the number of patients with wounds >50% covered with granulation tissue within 14 days. The incremental cost-effectiveness ratio (ICER was expressed as the additional cost spent with >50% granulation tissue per day per patient within 14 days of leg ulcer care.Results: Because of individual pricing of wound dressings in hospitals, cost data were derived from the outpatient sector. A total of 33 patients were treated using the PA-based hydrogel and 37 patients using the amorphous hydrogel. The estimated total direct costs per patient and per 14 days of therapy were €306 for both treatment groups. However, with the PA-based hydrogel, 2.5 additional days with wounds covered >50% with granulation tissues were gained within 14 days of leg ulcer care compared to the comparator. The ICER was €0 per additional day spent with >50% granulation tissue.Conclusion: Although there were a greater number of dressing changes in the PA-based hydrogel treatment, the total treatment cost for 14 days of leg ulcer care was the same for both

  19. Reseña Bibliográfica: Bastías, C. (et. al. 2011, Mujeres de la Vega. Género, memoria y trabajo en la Vega Central de Santiago. Chile Santiago, Salesianos Impresores S.A.

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    Eloísa Maldonado

    2014-01-01

    Full Text Available Una sugerente portada, que representa la gráfica y los colores de los carteles que habitualmente ofrecen los productos agrícolas, nos invita a entrar al mun­do de la Vega, uno de los mercados más importantes de Santiago. “Mujeres de la Vega. Género, memoria y trabajo en la Vega Central de Santiago” es el libro donde se dan a conocer los resultados de una investigación realizada entre agosto de 2010 y enero de 2011, financiada por el Consejo Nacional de la Cul­tura y las Artes, a través del Fondart Regional 2010. Sus autoras, Carolina Bastías, Licenciada en Historia de la Universidad Finis Terrae, Consuelo Hayden, Profesora de Historia y Ciencias Sociales de la Uni­versidad de Valparaíso y Magister (c en Estudios Latinoamericanos de la Uni­versidad de Chile, y Daniela Ibáñez, Antropóloga Social de la Universidad Aca­demia de Humanismo Cristiano y Magister (c en Estudios Latinoamericanos de la Universidad de Chile, se propusieron en esta investigación “dar a conocer, valorar y divulgar las prácticas que despliegan las mujeres de la Vega Central a partir de su trabajo en este espacio, con un énfasis especial en la dimensión de la memoria.”(Bastías, et. al, 2011, p.11 Se trata también de un esfuerzo por visibilizar su trabajo y aportar en la desmitificación que muchas veces instalan los medios de comunicación, de este mercado como un espacio masculino, de camiones, de carga y descarga de productos. Para esto no sólo profundizaron en un análisis sobre el trabajo femenino, sino también buscaron sus antecedentes en los orígenes mismos de La Vega como espacio de comercio y en la intimidad de la vida de once de sus trabajadoras, que revelaron en entrevistas en profundidad, sus historias, sus rutinas y sus ilusiones.

  20. 8-isorpostanes – markers for oxidative stress in obstructive sleep apnea patients with systolic dysfunction

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    Cherneva RV

    2013-06-01

    Full Text Available Radostina Vlaeva Cherneva,1 Ognian Borisov Georgiev,1 Daniela Stoichkova Petrova,1 Emil Ivanov Manov,2 Sylvia Rumenova Ruseva,3 Vanio Ivanov Mitev,3 Julia Ivanova Petrova4 1Department of Internal Medicine, Division of Pulmonary Medicine, Medical University of Sofia, Sofia, Bulgaria; 2Department of Internal Medicine, Division of Cardiology, Medical University of Sofia, Sofia, Bulgaria; 3Department of Medical Chemistry and Biochemistry, Laboratory of Synthesis and Analysis of Bioactive Substances, Medical University of Sofia, Sofia, Bulgaria; 4Department of Neurology, Medical University of Sofia, Sofia, Bulgaria Objective: Increased oxidative stress is considered to be an independent risk factor for cardiovascular diseases, but remains disputed in obstructive sleep apnea (OSA. Among oxidative stress markers, isorpostanes are considered to be the most sensitive and specific. Aims: The aim of the study was to compare urinary isorpostanes in patients with OSA and systolic dysfunction to patients with OSA and preserved ejection fraction (EF and determine their role as markers for increased oxidative stress and early cardiac damage. Materials and methods: Urinary 8F2-isorpostanes were measured in 30 patients with OSA and mild systolic dysfunction (EF = 45.7% ± 6.17% and compared to 15 patients with OSA and normal EF (EF = 60.3% ± 6.3%. Univariate regression analysis was performed to find predictors of left systolic dysfunction. Correlations between 8-isorpostanes, anthropometric, metabolic, and sleep study characteristics were explored. In addition, in 19 patients the effect of bilevel positive airway pressure (BiPAP therapy was evaluated during a 3 month follow-up. Markers of hemodynamic stress, N-terminal prohormone of brain natriuretic peptide and oxidative stress, measured by 8-isorpostanes were compared before and after the follow-up. Results: Urinary levels of 8-isorpostanes were significantly higher in the group with mild systolic dysfunction

  1. Impact of hospitalizations for bronchiolitis in preterm infants on long-term health care costs in Italy: a retrospective case-control study

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    Roggeri DP

    2016-08-01

    Full Text Available Daniela Paola Roggeri,1 Alessandro Roggeri,1 Elisa Rossi,2 Salvatore Cataudella,2 Nello Martini,3 1ProCure Solutions, Nembro, Bergamo, 2CINECA Interuniversity Consortium, Bologna, 3Accademia Nazionale di Medicina, Rome, Italy Purpose: Bronchiolitis is an acute inflammatory injury of the bronchioles, and is the most frequent cause of hospitalization for lower respiratory tract infections in preterm infants. This was a retrospective, observational, case-control study conducted in Italy, based on administrative database analysis. The aim of this study was to evaluate differences in health care costs of preterm infants with and without early hospitalization for bronchiolitis. Patients and methods: Preterm infants born in the period between January 1, 2009 and December 31, 2010 and hospitalized for bronchiolitis in the first year of life were selected from the ARNO Observatory database and observed for the first 4 years of life. These preterm infants were compared (paired 1–3 with preterm infants who were not hospitalized for bronchiolitis in the first year of life and with similar characteristics. Only direct health care costs reimbursed by the Italian National Health Service were considered for this study (drugs, hospitalizations, and diagnostic/therapeutic procedures. Results: Of 40,823 newborns in the accrual period, 863 were preterm with no evidence of prophylaxis, and 22 preterm infants were hospitalized for bronchiolitis (cases and paired with 62 controls. Overall, cases had 74% higher average cost per infant in the first 4 years of life than controls (18,624€ versus 10,189€, respectively. The major cost drivers were hospitalizations, accounting for >90% in both the populations. The increase in total yearly health care cost between cases and controls remained substantial even in the fourth year of life for all cost items. A relevant increase in hospitalizations and drug consumption linked to respiratory tract diseases was noted in

  2. Economic impact of the use of rifaximin 550 mg twice daily for the treatment of overt hepatic encephalopathy in Italy

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    Roggeri DP

    2017-09-01

    Full Text Available Daniela Paola Roggeri, Alessandro Roggeri ProCure Solutions, Nembro, Bergamo, Italy Purpose: Hepatic encephalopathy (HE is associated with a reduced survival, an increased risk of hospitalization for recurrences, and a reduced health-related quality of life. The purpose of the present economic analysis was to evaluate the impact on the Italian National Health Service (INHS expenditure of the treatment with rifaximin 550 mg twice daily (Tixteller®/Tixtar® for the reduction of the recurrences of overt HE, with respect to the current treatment approach. Patients and methods: Costs associated with patients treated with rifaximin 550 mg twice daily were estimated considering the reduction in hospitalizations for HE recurrences revealed by registrative clinical trial (−50% applied to the hospitalization rate (42.5% emerging from an Italian observational real-world study; costs associated with patients not treated with rifaximin were estimated based on the hospitalization rate, resulting from the same Italian observational study. Sensitivity analyses considering possible different discount levels to INHS structures for rifaximin were performed. The INHS perspective for a period of 3 years was considered. Results: The treatment with rifaximin 550 mg twice daily, although increasing drug costs, is associated with a reduction in hospitalizations for HE recurrences that leads to an overall reduction of total costs charged to INHS, which could be estimated, based on the forecasted uptake of the treatment, at about €130,000 in the first year, reaching ~€260,000 in the third year. Considering a possible discount for rifaximin 550 mg to INHS structure of 20%, the total saving at the third year accounts for ~€3,000,000. Moreover, a relevant reduction in the number of hospitalizations and bed days is associated with rifaximin treatment. Conclusion: The treatment with rifaximin 550 mg twice daily, even if associated with an increase in drug expenditure

  3. ÍNDICE

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    MARÍA JESUS MARRON GAITE

    2015-12-01

    Full Text Available PRESENTACIÓN: La investigación en Educación GeográficaCOORDINACIÓN: Ramón Martínez Medina.................................................... 7ARTÍCULOSFormer ses élèves à L’abstraction en géographieBernadette Mérenne-Schoumaker................................................................ 25El paisaje en la Educación Secundaria Obligatoria. Una oportunidad educativa en el cambio curricular LOE-LOMCEMaría Casas Jericó y Luis Erneta Altarriba ...................................................... 4Parques naturales: la necesaria conceptualización transformadora en la Educación Primaria y SecundariaDiana Santana Martín, Antonio José Morales Hernández, Juan Carlos Colomer Rubio, Benito Campo Pais, Carlos Caurín Alonso............................................ 73Le territoire, un concept sensible : enjeux didactiques et politiques dans le contexte scolaire françaisEric Ratzel et Jean-François Thémines..................................................................................................95La obra La recogida de la manzana como pretexto para la lectura e interpretación del paisaje tradicional a través de una fuente iconográfica: un estudio con alumnado de 2º de BachilleratoRoberto García-Morís..................................................................................................... 115Propuesta didáctica para la interpretación del espacio geográfico: la ciudad de Segovia y su entornoLuis Carlos Martínez Fernández, Berta Fernández-Vega Peláez e Ignacio Molina de la Torre.................................................................................................. 135Aportes del enfoque de género para una enseñanza inclusiva de la Geografía escolarMaría Victoria Fernández Caso y Daniela Guberman....................................... 165El modelo TPACK en los estudios de Grado para la formación inicial del profesorado en TIC Isabel Mª Gómez Trigueros

  4. Novel targeting using nanoparticles: an approach to the development of an effective anti-leishmanial drug-delivery system

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    Ribeiro TG

    2014-02-01

    Full Text Available Tatiana G Ribeiro,1 Miguel A Chávez-Fumagalli,2 Diogo G Valadares,3 Juçara R França,1 Lívia B Rodrigues,1 Mariana C Duarte,2 Paula S Lage,2 Pedro H R Andrade,4 Daniela P Lage,4 Leonardo V Arruda,5,6 Daniel R Abánades,5,6 Lourena E Costa,2 Vivian T Martins,3 Carlos AP Tavares,3 Rachel O Castilho,1,7,* Eduardo AF Coelho,2,4,* André AG Faraco1,7,*1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 3Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 4Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 5Programa de Pós-Graduação em Patologia Humana, Universidade Federal da Bahia, Salvador, Bahia, Brazil; 6Centro de Pesquisas Gonçalo Moniz (CPqGM, Fundação Oswaldo Cruz (FIOCRUZ, Salvador, Bahia, Brazil; 7Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil*These authors contributed equally to this workAbstract: The study reported here aimed to develop an optimized nanoparticle delivery system for amphotericin B (AmpB using a polyelectrolyte complexation technique. For this, two oppositely charged polymers presenting anti-leishmanial activity – chitosan (Cs and chondroitin sulfate (ChS – were used: Cs as a positively charged polymer and ChS as a negatively charged polymer. The chitosan (NQ nanoparticles, chitosan-chondroitin sulfate (NQC nanoparticles, and chitosan-chondroitin sulfate-amphotericin B (NQC-AmpB nanoparticles presented a mean particle size of 79, 104, and 136 nm, respectively; and

  5. A software program designed to educate patients on age-related skin changes of facial and exposed extrafacial regions: the results of a validation study

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    Goodman GJ

    2012-01-01

    Full Text Available Greg J Goodman1, Michael B Halstead2, John D Rogers2, Daniela Borzillo1, Elizabeth Ryan1, Nick Riley3, John Wlodarczyk31Dermatology Institute of Victoria, South Yarra, Victoria, Australia; 2Allergan Australia, Gordon, NSW, Australia; 3John Wlodarczyk Consulting Services, New Lambton, NSW, AustraliaBackground: A software program called "HOYS" has been developed to depict various aspects and degrees of aging at 35 constituent subregions of seven distinct facial or exposed extrafacial regions. This program is underpinned by five-point photonumeric Likert scales characterizing skin surface and volume changes across five decades for each of the 35 subregions, and features an interactive skin-age assessment with a treatment-prioritization tool. In this study, the reliability and reproducibility of these scales was evaluated.Methods: Eleven physicians and 19 non-physicians participated in this study. The five images from each of the 35 Likert scales in the HOYS program were shown on a total of 43 display boards, with selected subregions presented at rest or with movement, consistent with this program. Each image was randomly labeled between "A–E," corresponding to a range of skin ages by decade from 20–69 years. Each rater was asked to rank these images from youngest to oldest (or least to most severe deficit for each scale and to repeat this exercise 2 hours later, with the intra- and inter-rater reliability evaluated. The raters were also asked to estimate the age of a single randomly allocated image on each scale for the purposes of internal validation.Results: The overall inter-rater reliability of the raters was high at the first ranking session (weighted kappa: 0.78; 95% confidence intervals [95% CI]: 0.77–0.79 and this was confirmed when repeated 2 hours later (0.82; 95% CI: 0.81–0.83, with an intra-rater reliability of 0.76 (95% CI: 0.75–0.77. There was no significant difference in the physicians' and non-physicians' rankings. The

  6. Evaluating targets and costs of treatment for secondary hyperparathyroidism in incident dialysis patients: the FARO-2 study

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    Roggeri DP

    2014-12-01

    Full Text Available Daniela Paola Roggeri,1 Mario Cozzolino,2 Sandro Mazzaferro,3 Diego Brancaccio,4 Ernesto Paoletti,5 Alessandro Roggeri,1 Anna Maria Costanzo,6 Umberto di Luzio Paparatti,6 Vincenzo Festa,6 Piergiorgio Messa7 1ProCure Solutions, Nembro, Bergamo, 2Department of Health Sciences, University of Milan, Milan, 3Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, Sapienza University of Rome, Rome, 4Dialysis Unit NephroCare Simone Martini, Milan, 5Department of Nephrology, San Martino Hospital, Genoa, 6AbbVie Italy, Campoverde, Latina, 7Nephrology, Dialysis and Renal Transplant, Fondazione Ca Granda IRCCS Policlinico, Milan, Italy  On behalf of the FARO Study Group Background: The aim of this analysis was to estimate biochemical parameters and the costs of treatment of secondary hyperparathyroidism (SHPT in a subpopulation of the FARO-2 study. Methods: The FARO-2 observational study aimed at evaluating the patterns of treatment for SHPT in naïve hemodialysis patients. Data related to pharmacological treatments and biochemical parameters (parathyroid hormone [PTH], calcium, phosphate were recorded at entry to hemodialysis (baseline and 6 months later (second survey. The analysis was performed from the Italian National Health Service perspective. Results: Two prominent treatment groups were identified, ie, one on oral calcitriol (n=105 and the other on intravenous paricalcitol (n=33; the intravenous calcitriol and intravenous paricalcitol + cinacalcet combination groups were not analyzed due to low patient numbers. At baseline, serum PTH levels were significantly higher in the intravenous paricalcitol group (P<0.0001. At the second survey, the intravenous paricalcitol group showed a higher percentage of patients at target for PTH than in the oral calcitriol group without changing the percentage of patients at target for phosphate. Moreover, between baseline and the second survey, intravenous paricalcitol significantly increased

  7. Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

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    Antinori A

    2016-05-01

    Full Text Available Andrea Antinori,1 Paola Meraviglia,2 Antonella d’Arminio Monforte,3,4 Antonella Castagna,5,6 Cristina Mussini,7 Teresa Bini,4 Nicola Gianotti,5 Stefano Rusconi,8 Elisa Colella,8 Giuseppe Airoldi,9 Daniela Mancusi,10 Roberta Termini10 1Clinical Department, National Institute for Infectious Diseases “L. Spallanzani”, Rome, 2Department of Infectious Disease, “L. Sacco” University Hospital, 3Department of Health Sciences – University of Milan, 4Clinic of Infectious Diseases, “San Paolo” Hospital, 5Infectious Diseases, San Raffaele Scientific Institute, 6Università Vita-Salute San Raffaele, Milan, 7Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, 8Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan, 9Studio Associato Airoldi, Cicogna, Ghirri, 10Janssen-Cilag SpA, Medical Affairs, Cologno Monzese, Milan, Italy Abstract: Current antiretroviral (ARV therapy for the treatment of human immunodeficiency virus (HIV-1-infected patients provides long-term control of viral load (VL. Darunavir (DRV is a nonpeptidomimetic protease inhibitor approved for use with a ritonavir booster (DRV/r. This study evaluated the effectiveness of DRV/r in combination with other ARV agents in routine clinical practice in Italy. In this descriptive observational study, data on utilization of DRV/r, under the conditions described in the marketing authorization, were collected from June 2009 to December 2012. Effectiveness (VL <50 copies/mL, tolerability, and durability in four patient groups (two DRV/r-experienced, one ARV-experienced DRV/r-naïve, and one ARV-naïve were analyzed. Secondary objectives included immunological response, safety, and persistence/discontinuation rates. In total, 875 of 883 enrolled patients were included in the analysis: of these, 662 (75.7% completed the follow-up until the end of 2012 and 213 (24.3% withdrew from the study earlier. Initial DRV dose was 600 mg twice daily (67.1% or 800

  8. Stroke warning campaigns: delivering better patient outcomes? A systematic review

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    Mellon L

    2015-02-01

    Full Text Available Lisa Mellon,1 Frank Doyle,1 Daniela Rohde,1 David Williams,2 Anne Hickey1 1Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland; 2Department of Geriatric and Stroke Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland Background: Patient delay in presenting to hospital with stroke symptoms remains one of the major barriers to thrombolysis treatment, leading to its suboptimal use internationally. Educational interventions such as mass media campaigns and community initiatives aim to reduce patient delays by promoting the signs and symptoms of a stroke, but no consistent evidence exists to show that such interventions result in appropriate behavioral responses to stroke symptoms. Methods: A systematic literature search and narrative synthesis were conducted to examine whether public educational interventions were successful in the reduction of patient delay to hospital presentation with stroke symptoms. Three databases, MEDLINE, CINAHL, and PsycINFO, were searched to identify quantitative studies with measurable behavioral end points, including time to hospital presentation, thrombolysis rates, ambulance use, and emergency department (ED presentations with stroke. Results: Fifteen studies met the inclusion criteria: one randomized controlled trial, two time series analyses, three controlled before and after studies, five uncontrolled before and after studies, two retrospective observational studies, and two prospective observational studies. Studies were heterogeneous in quality; thus, meta-analysis was not feasible. Thirteen studies examined prehospital delay, with ten studies reporting a significant reduction in delay times, with a varied magnitude of effect. Eight studies examined thrombolysis rates, with only three studies reporting a statistically significant increase in thrombolysis administration. Five studies examined ambulance usage, and four reported a statistically significant increase in ambulance

  9. Influence of optic disc size on the diagnostic performance of macular ganglion cell complex and peripapillary retinal nerve fiber layer analyses in glaucoma

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    Cordeiro DV

    2011-09-01

    Full Text Available Daniela Valença Cordeiro1, Verônica Castro Lima1,2, Dinorah P Castro1,3, Leonardo C Castro1,3, Maria Angélica Pacheco2, Jae Min Lee2, Marcelo I Dimantas2, Tiago Santos Prata1,21Department of Ophthalmology, Federal University of São Paulo, São Paulo, 2Hospital Medicina dos Olhos, São Paulo, 3Centro Brasileiro de Especialidades Oftalmológicas, Araraquara, BrazilAim: To evaluate the influence of optic disc size on the diagnostic accuracy of macular ganglion cell complex (GCC and conventional peripapillary retinal nerve fiber layer (pRNFL analyses provided by spectral domain optical coherence tomography (SD-OCT in glaucoma.Methods: Eighty-two glaucoma patients and 30 healthy subjects were included. All patients underwent GCC (7 × 7 mm macular grid, consisting of RNFL, ganglion cell and inner plexiform layers and pRNFL thickness measurement (3.45 mm circular scan by SD-OCT. One eye was randomly selected for analysis. Initially, receiver operating characteristic (ROC curves were generated for different GCC and pRNFL parameters. The effect of disc area on the diagnostic accuracy of these parameters was evaluated using a logistic ROC regression model. Subsequently, 1.5, 2.0, and 2.5 mm2 disc sizes were arbitrarily chosen (based on data distribution and the predicted areas under the ROC curves (AUCs and sensitivities were compared at fixed specificities for each.Results: Average mean deviation index for glaucomatous eyes was -5.3 ± 5.2 dB. Similar AUCs were found for the best pRNFL (average thickness = 0.872 and GCC parameters (average thickness = 0.824; P = 0.19.The coefficient representing disc area in the ROC regression model was not statistically significant for average pRNFL thickness (-0.176 or average GCC thickness (0.088; P ≥ 0.56. AUCs for fixed disc areas (1.5, 2.0, and 2.5 mm2 were 0.904, 0.891, and 0.875 for average pRNFL thickness and 0.834, 0.842, and 0.851 for average GCC thickness, respectively. The highest sensitivities – at

  10. Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: a randomized controlled trial

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    Ramirez-Campillo R

    2016-12-01

    Full Text Available Rodrigo Ramirez-Campillo,1–3 Daniela Diaz,4 Cristian Martinez-Salazar,5 Pablo Valdés-Badilla,6 Pedro Delgado-Floody,5 Guillermo Méndez-Rebolledo,7 Rodrigo Cañas-Jamet,8,9 Carlos Cristi-Montero,10 Antonio García-Hermoso,11 Carlos Celis-Morales,12 Jason Moran,13 Thomas W Buford,14 Leocadio Rodriguez-Mañas,15 Alicia M Alonso-Martinez,16 Mikel Izquierdo16 1Department of Physical Activity Sciences, 2Laboratory of Measurement and Assessment in Sports, Research Nucleus in Health, Physical Activity and Sports, Universidad de Los Lagos, Osorno, 3Unit of Integrative Physiology, Laboratory of Exercise Sciences, MEDS Clinic, Santiago, Chile; 4School of Occupational Therapy, Faculty of Health, Universidad Santo Tomás, Osorno, 5Department of Physical Education, Sport and Recreation, Universidad de La Frontera, 6Institute of Physical Activity and Health, Universidad Autónoma de Chile, Temuco, 7School of Kinesiology, Faculty of Health, University Santo Tomás, Talca, 8Laboratory of Physiology, Department of Biological Sciences, Faculty of Biological Sciences, Universidad Andres Bello, Viña del Mar, 9School of Kinesiology, Faculty of Medicine, Universidad Diego Portales, Santiago, 10IRyS Group, Physical Education School, Pontificia Universidad Católica de Valparaíso, Valparaíso, 11Laboratory of Physical Activity Sciences, Sport and Health, Faculty of Medical Sciences, Universidad de Santiago de Chile, USACH, Santiago, Chile; 12BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, 13Centre for Sports and Exercise Science, School of Biological Sciences, University of Essex, Colchester, UK; 14Department of Aging and Geriatric Research, Institute of Aging, University of Florida, College of Medicine, Gainesville, Florida, USA; 15Division of Geriatric Medicine, University Hospital of Getafe, Madrid, 16Department of Health Sciences, Public University of Navarre, Navarre, Spain

  11. Comparison of three screening tests for autism in preterm children with birth weights less than 1,500 grams

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    Dudova I

    2014-11-01

    Full Text Available Iva Dudova,1 Daniela Markova,2 Martina Kasparova,3 Jana Zemankova,4 Stepanka Beranova,1 Tomas Urbanek,5 Michal Hrdlicka1 1Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 2Department of Pediatrics and Adolescent Medicine, Charles University First Faculty of Medicine and General University Hospital, Prague, Czech Republic; 3Department of Pediatrics, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 4Department of Pediatrics, Charles University Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic; 5Institute of Psychology, Academy of Sciences, Brno, Czech Republic Background: Preterm children seem to be at increased risk for autism spectrum disorders (ASD. Methods: Parents of 157 children with birth weights less than 1,500 g (age 2 years, corrected for prematurity; 88 boys, 69 girls completed screening questionnaires. The screening battery included the Modified Checklist for Autism in Toddlers (M-CHAT, Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist (CSBS-DP-ITC, and the Infant/Toddler Sensory Profile (ITSP. Children with disabilities were excluded. All children who screened positive on any of the screening tools were subsequently assessed by clinical examination including the Autism Diagnostic Observation Schedule. Results: Fifty-six children (35.7% screened positive on at least one of the parental screening questionnaires. Of the 56 children who tested positive, 33 participated in the detailed clinical follow-up assessment. A diagnosis of ASD was confirmed in 13 of the 33 children. The ASD prevalence was 9.7% of the sample. Analysis of children with and without an ASD diagnosis found significant differences relative to gestational age (26.9 weeks vs 28.3 weeks, P=0.033 and length of the stay in hospital (89.5 days vs 75.4 days, P=0.042. The

  12. Quality of life and parental styles assessed by adolescents suffering from inflammatory bowel diseases and their parents

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    Jelenova D

    2016-03-01

    Full Text Available Daniela Jelenova,1 Jan Prasko,1 Marie Ociskova,1 Klara Latalova,1 Eva Karaskova,2 Radovan Hruby,3 Dana Kamaradova,1 Vladimir Mihal21Department of Psychiatry, 2Department of Pediatrics, Faculty of Medicine and Dentistry, Palacký University, University Hospital, Olomouc, Czech Republic; 3Private Practice, Martin, Slovak RepublicBackground: Inflammatory bowel diseases (IBDs in adolescents are chronic medical conditions with a substantial influence on the quality of life (QoL of the families.Methods: A total of 27 adolescents suffering from IBD, 39 healthy adolescents, and their parents were included in the cross-sectional study. The adolescents completed the questionnaires ADOR (parenting styles, KidScreen-10 (QoL, SAD (The Scale of Anxiety in Children, and CDI (Children’s Depression Inventory. The parents completed the BAI (Beck Anxiety Inventory, BDI-II (Beck Depression Inventory, second version, and PedsQL (Pediatrics Quality of Life Family Impact Module.Results: The parental styles of the parents of the IBD adolescents and controls were without significant differences. The only exception was that fathers’ positive parental style was significantly higher in the fathers of the controls. There were no statistically significant differences between the IBD children and controls in the QoL assessed using KidScreen-10. However, the QoL of the parents of the ill children was significantly lower than that of the parents of the controls (PedsQL total scores in mothers 66.84±14.78 vs 76.17±14.65 and in fathers 68.86±16.35 vs 81.74±12.89, respectively. The mothers of the IBD adolescents were significantly more anxious (BAI scores 9.50±10.38 vs 5.26±4.75 and the fathers more depressed (BDI-II scores 7.23±6.50 vs 3.64±3.51 than the parents of the controls, but there was no difference in the levels of anxiety or depression between the IBD adolescents and the controls. The positive parental style of both the parents of the children suffering from

  13. 2015 Brainhack Proceedings

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    R. Cameron Craddock

    2016-11-01

    high-performance computing environments Hans J. Johnson A16 Facilitating big data meta-analyses for clinical neuroimaging through ENIGMA wrapper scripts Erik Kan, Julia Anglin, Michael Borich, Neda Jahanshad, Paul Thompson, Sook-Lei Liew A17 A cortical surface-based geodesic distance package for Python Daniel S Margulies, Marcel Falkiewicz, Julia M Huntenburg A18 Sharing data in the cloud David O’Connor, Daniel J. Clark, Michael P. Milham, R. Cameron Craddock A19 Detecting task-based fMRI compliance using plan abandonment techniques Ramon Fraga Pereira, Anibal Sólon Heinsfeld, Alexandre Rosa Franco, Augusto Buchweitz, Felipe Meneguzzi A20 Self-organization and brain function Jörg P. Pfannmöller, Rickson Mesquita, Luis C.T. Herrera, Daniela Dentico A21 The Neuroimaging Data Model (NIDM API Vanessa Sochat, B Nolan Nichols A22 NeuroView: a customizable browser-base utility Anibal Sólon Heinsfeld, Alexandre Rosa Franco, Augusto Buchweitz, Felipe Meneguzzi A23 DIPY: Brain tissue classification Julio E. Villalon-Reina, Eleftherios Garyfallidis

  14. Editorial

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    José Yvan P. Leite

    2015-12-01

    Full Text Available Este volume publica resultados da área de tecnologia mineral, em particular do tradicional evento da área de tecnologia mineral que iniciou seu primeiro encontro em 1973 no Rio de Janeiro e organizado pela COPPE – Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia, da Universidade Federal do Rio de Janeiro (UFRJ e denominado de Encontro Nacional de Tratamento de Minérios. Este periódico em 2013, durante realização do XXV Encontro Nacional de Tratamento de Minérios e Metalurgia Extrativa (ENTMME e VIII Meeting of the Southern Hemisphere on Mineral Technology (MSHMT, em Goiânia/GO, coordenado pelo prof. André Silva da Universidade Federal de Goiás, celebrou uma parceria para a publicação de uma edição especial, com artigos do evento, os quais foram publicados no Vol. 3 de 2014 - http://www2.ifrn.edu.br/ojs/index.php/HOLOS/issue/view/63 Este entendimento foi mantido com a organização do XXVI ENTMME, que foi realizado em Poços de Caldas/MG e coordenado pelos professores Maurício Bergerman (Universidade de São Paulo - USP e Daniela Horta (Universidade Federal de Alfenas - UNIFAL. A importância da mineração no país justifica uma edição para ampliar a difusão neste campo, em particular o elevado impacto que esta área tem no PIB brasileiro e sua disseminação nos vários estados brasileiros. O recente desastre sócio-ambiental provocado pelo rompimento de barragem de rejeitos da Samarco, em Mariana/MG, coloca em evidência uma face negativa da mineração. O tema merece aprofundamento da comunidade acadêmica e este periódico fomentará uma edição especial em 2016 para discutir o tema. É importante compartilhar que o periódico passa a integrar a base Web of Science da Thomson Reuters, que pela importância amplia a visibilidade dos artigos publicados por estes lados do hemisfério sul. Nesta edição são publicados 21 artigos  com contribuições nas áreas de caracterização tecnol

  15. Equipe de trabalho

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    Gabriel Gerber Hornink

    2014-08-01

    Junior, Centro de Ciências Naturais e Humanas (CCNH Universidade Federal do ABC (UFABC, Brasil Raul Herrera Faúndez, Instituto de Biología Vegetal y Biotecnologia, Universidad de Talca, Chile Wagner Seixas da Silva, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro (UFRJ, Brasil 2. Avaliadores (Jan-Jul, 2014 Adriana Cassina, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguai André Amaral Gonçalves Bianco, Universidade Federal de São Paulo (Unifesp, Brasil Daniela Kiyoko Yokaichiya, Doutora em Bioquímica (Unicamp. Eduardo Galembeck, Departamento de Bioquímica Instituto de Biologia, UNICAMP, Brasil Gabriel Gerber Hornink, Depto. Bioquímica, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas (Unifal-MG, Brasil Jair Adriano Kopke de Aguiar, Departamento de Bioquímica/ICB, Universidade Federal de Juiz de Fora (UFJF, Brasil José Maurício Scheedorf da Silva, Departamento de Bioquímica/ ICB, Universidade Federal de Alfenas (Unifal-MG Leila Maria Beltramini, Instituto de Física de São Carlos, Universidade Estadual de São Paulo - USP, Brasil Manuel João da Costa, Escola de Ciências da Saúde, Universidade do Minho, Portugal Maria Elena Infante-Malachias, Universidade de São Paulo (USP, Brasil Maria Lucia Bianconi, Instituto de Bioquímica Médica Universidade Federal do Rio de Janeiro (UFRJ, Brasil Mauricio Roberto Motta Pinto da Luz, Instituto Oswaldo Cruz - Fundação Oswaldo Cruz Nelma Regina Segnini Bossolan, Instituto de Física de São Carlos, Universidade de São Paulo - USP, Brasil Paulo De Avila Junior, Centro de Ciências Naturais e Humanas (CCNH Universidade Federal do ABC (UFABC, Brasil Paulo Granjeiro, Laboratório de Processos Biotecnológicos e Purificação de Macromoléculas, Universidade Federal de São João Del-Rei (UFJS, Brasil Vera Maria Treis Trindade, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do

  16. Editorial

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    José Yvan Pereira Leite

    2015-10-01

    . Entre os estados brasileiros, os principais acessos são oriundos dos Estados de São Paulo, Rio Grande do Norte, Minas Gerais, Rio de Janeiro, Rio Grande do Sul, Paraná, Ceará, Bahia, Pernambuco e Santa Catarina. Esta quinto volume apresenta 33 artigos de várias áreas do conhecimento, afirmando o caráter interdisciplinar do periódico e sua inserção em várias área de avaliação do Qualis da CAPES. O tempo é de inovar para consolidar as ações editoriais de longo prazo e com este objetivo o Conselho Editorial é ampliado com a presença de docentes da Universidade de São Paulo (prof. Maurício Bergerman, da Universidade Federal de Alfenas (profa. Daniela Gomes Horta, da Universidade Federal de Campina Grande (prof. Gesinaldo Ataíde Cândido e da Universidade do Minho (prof. Bento Duarte Silva.  A editoria reafirma o compromisso com a qualidade e difusão do conhecimento, bem como a busca permanente para ampliar a visibilidade dos artigos aqui publicados. Enfim,  esta editoria agradece aos autores pela escolha da publicação dos seus artigos neste periódico, aos pareceristas ad hoc pelo trabalho desenvolvido na análise dos manuscritos e ao Conselho Editorial, que na atmosfera global validam as ações desenvolvidas neste periódico. Convido-os a acessarem o sumário e de forma sublime encontrar artigos do vosso interesse e, quando encontrá-los dialogue com seus autores, cite-os e compartilhe em suas redes. À leitura! Natal, 30 de setembro de 2015. Prof. José Yvan Pereira Leite

  17. Editorial

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    Márcio Matias

    2012-01-01

    Garcia Rosa. Além disto, esta edição também apresenta trabalhos sobre diversos aspectos ligados à comunicação científica, tais como qualidade, visibilidade, indicadores de gestão de fluxo editorial, curadoria digital, repositórios e preservação digital, que são listados a seguir: Metadados de qualidade e visibilidade na comunicação científica, de Silvia Maria Puentes Bentancourt e Rafael Port da Rocha; Indicadores de gestão do fluxo editorial dos periódicos científicos: uma reflexão teórico-metodológica, deElisabete Werlang, Daniela Spudeit e Nadi Helena Presser; O impacto da curadoria digital dos dados de pesquisa na Comunicação Científica de Luana Farias Sales e Luís Fernando Sayão; Análise da dinâmica de evolução das revistas científicas e bibliotecas digitais de teses e dissertações em acesso livre na área de Ciências da Comunicação: o caso do repositório Univerciencia.org, deDalton Lopes Martins e Sueli Mara Soares Pinto Ferreira; Acesso livre via repositórios: politicas de instituições brasileiras, de Tania Chalhub , Alegria Benchimol e Claudia Guerra; O papel das bibliotecas universitárias na comunicação científica: um estudo sobre os repositórios institucionais, de Patrícia dos Santos Caldas Marra; Acesso Livre à Informação Científica em Países em Desenvolvimento: o caso dos Repositórios “Saber” (Moçambique e Digital da UFMG (Brasil, de Ranito Zambo Waete, Maria Aparecida Moura, e Manuel Valente Mangue; SEER e PDF/A na preservação de revistas científicas: relato de experiência, de Ana Paula Araújo Cabral da Silva; Ontologia de dependência tecnológica de documentos digitais: Instrumento de Apoio à Preservação Digital, de Eloi Juniti Yamaoka e Fernando Ostuni Gauthier. Vale também destacar a nossa bela capa gentilmente elaborada pelo professor Adilson Luiz Pinto. Ótima leitura! Márcio Matias e Moisés Lima Dutra Editores – Edição Especial – 3º SBCC – Perspectivas em Acesso Aberto

  18. Burnei's "double X" internal fixation technique for supracondylar humerus fractures in children: indications, technique, advantages and alternative interventions : Study and Research Group in Pediatric Orthopaedics-2012.

    Science.gov (United States)

    Georgescu, I; Gavriliu, S; Pârvan, A; Martiniuc, A; Japie, E; Ghiță, R; Drăghici, I; Hamei, Ş; Ţiripa, I; El Nayef, T; Dan, D

    2013-06-15

    The Study and Research Group in Pediatric Orthopedics-2012 initated this retrospective study due to the fact that in Romania and in other countries, the numerous procedures do not ensure the physicians a definite point of view related to the therapeutic criteria in the treatment of supracondylar fractures. That is why the number of complications and their severity brought into notice these existent deficiencies. In order to correct some of these complications, cubitus varus or valgus, Prof. Al. Pesamosca communicated a paper called "Personal procedure in the treatment of posttraumatic cubitus varus" at the County Conference from Bacău, in June 24, 1978. This procedure has next been made popular by Prof. Gh. Burnei and his coworkers by operating patients with cubitus varus or valgus due to supracondylar humeral fractures and by presenting papers related to the subject at the national and international congresses. The latest paper regarding this problem has been presented at the 29th Annual Meeting of the European Pediatric Orthopedic Society in Zagreb, Croatia, April 7-10, 2010, being titled "Distal humeral Z-osteotomy for posttraumatic cubitus varus or valgus", having as authors Gh. Burnei, Ileana Georgescu, Ştefan Gavriliu, Costel Vlad and Daniela Dan. As members of this group, based on the performed studies, we wish to make popular this type of osteosynthesis, which ensures a tight fixation, avoids complications and allows a rapid postoperative activity. The acknowledged treatment for these types of fractures is the orthopedic one and it must be accomplished as soon as possible, in the first 6 hours, by reduction and cast immobilization or by closed or open reduction and fixation, using one of the several methods (Judet, Boehler, Kapandji, San Antonio, San Diego, Burnei's double X technique). The exposed treatment is indicated in irreducible supracondylar humeral fractures, in reducible, but unstable type, in polytraumatized patients with supracondylar

  19. Burnei’s “double X" internal fixation technique for supracondylar humerus fractures in children: indications, technique, advantages and alternative interventions

    Science.gov (United States)

    Georgescu, I; Gavriliu, S; Pârvan, A; Martiniuc, A; Japie, E; Ghiță, R; Drăghici, I; Hamei, S; Ţiripa, I; El Nayef, T; Dan, D

    2013-01-01

    Background. The Study and Research Group in Pediatric Orthopedics-2012 initated this retrospective study due to the fact that in Romania and in other countries, the numerous procedures do not ensure the physicians a definite point of view related to the therapeutic criteria in the treatment of supracondylar fractures. That is why the number of complications and their severity brought into notice these existent deficiencies. In order to correct some of these complications, cubitus varus or valgus, Prof. Al. Pesamosca communicated a paper called "Personal procedure in the treatment of posttraumatic cubitus varus" at the County Conference from Bacău, in June 24, 1978. This procedure has next been made popular by Prof. Gh. Burnei and his coworkers by operating patients with cubitus varus or valgus due to supracondylar humeral fractures and by presenting papers related to the subject at the national and international congresses. The latest paper regarding this problem has been presented at the 29th Annual Meeting of the European Pediatric Orthopedic Society in Zagreb, Croatia, April 7-10, 2010, being titled “Distal humeral Z-osteotomy for posttraumatic cubitus varus or valgus", having as authors Gh. Burnei, Ileana Georgescu, Ştefan Gavriliu, Costel Vlad and Daniela Dan. As members of this group, based on the performed studies, we wish to make popular this type of osteosynthesis, which ensures a tight fixation, avoids complications and allows a rapid postoperative activity. Introduction. The acknowledged treatment for these types of fractures is the orthopedic one and it must be accomplished as soon as possible, in the first 6 hours, by reduction and cast immobilization or by closed or open reduction and fixation, using one of the several methods (Judet, Boehler, Kapandji, San Antonio, San Diego, Burnei’s double X technique). The exposed treatment is indicated in irreducible supracondylar humeral fractures, in reducible, but unstable type, in polytraumatized

  20. Expediente - 2014 (2

    Directory of Open Access Journals (Sweden)

    Revista de Ensino de Bioquímica

    2014-10-01

    Junior, Centro de Ciências Naturais e Humanas (CCNH Universidade Federal do ABC (UFABC, Brasil Raul Herrera Faúndez, Instituto de Biología Vegetal y Biotecnologia, Universidad de Talca, Chile Wagner Seixas da Silva, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro (UFRJ, Brasil 2. Avaliadores V12. N2, 2014 Adriana Cassina, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguai. André Amaral Gonçalves Bianco, Universidade Federal de São Paulo (Unifesp, Brasil. Daniela Kiyoko Yokaichiya, Doutora em Bioquímica, EUA. Eduardo Galembeck, Departamento de Bioquímica Instituto de Biologia, UNICAMP, Brasil. Gabriel Gerber Hornink, Depto. Bioquímica, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas (Unifal-MG, Brasil. Jair Adriano Kopke de Aguiar, Departamento de Bioquímica/ICB, Universidade Federal de Juiz de Fora (UFJF, Brasil. José Maurício Scheedorf da Silva, Departamento de Bioquímica/ ICB, Universidade Federal de Alfenas (Unifal-MG, Brasil. Leila Maria Beltramini, Instituto de Física de São Carlos, Universidade Estadual de São Paulo - USP, Brasil Marília Gabriella Alves Goulart Pereira, Departamento de Bioquímica/ ICB, Universidade Federal de Alfenas (Unifal-MG, Brasil. Marise Fonseca dos Santos, Universidade Federal do Paraná, Brasil. Michele Waltz Comar, Instituto Federal do Espírito Santo, Brasil. Miguel Ángel MedinaTorres, Departamento de Biologia Molecular e Bioquímica, Faculdade de Ciências, Universidade de Málaga, Espanha. Paulo De Avila Junior, Centro de Ciências Naturais e Humanas (CCNH Universidade Federal do ABC (UFABC, Brasil Patrícia Cristina Rodrigues, Pós-doutoranda, Fundação Oswaldo Cruz, Brasil. Rodrigo Maciel Lima, Instituto Federal de Educação, Ciência e Tecnologia Fluminense, Brasil. Thiago Corrêa de Souza, Instituto de Ciências da natureza, Universidade Federal de Alfenas (Unifal-MG, Brasil. Vera Maria Treis Trindade, Instituto de Ciências B

  1. Acknowledgments to Brazilian Journal of Family and Community Medicine (RBMFC Reviewers

    Directory of Open Access Journals (Sweden)

    Revista Brasileira de Medicina de Família e Comunidade RBMFC

    2012-12-01

    Full Text Available A Revista Brasileira de Medicina de Família e Comunidade (RBMFC agradece aos membros de seu Corpo Editorial abaixo listados, pelas horas dedicadas voluntariamente para avaliação dos trabalhos submetidos à publicação e pelas demais contribuições para a melhoria da qualidade científica de nosso periódico.Adilson Domingos dos Reis Filho - UNIC Adriana Valéria Assunção Ramos - UNIFOR Airton Tetelbom Stein - UFCSPA Alberto Novaes Ramos Jr - UFC Aldaísa Cassanho Forster - UNIVALI Alessandro da Silva Scholze - UNIVALI Alessandro Leite Cavalcanti - UFPB Alexsandro Nascimento Costa - UESB Aline Guerra Aquilante - UFSCar Altacílio Aparecido Nunes - USP Amaury Lelis Dal-Fabbro - USP Ana Cristina Vidor - PFM Ana Maria Galdini Raimundo Oda - UFSCar Ana Maria Garcia Andrade - PMPA Ana Regina Noto Faria - UNIFESP Anderson Soares Silva - USP André  Messias - USP André Luís Andrade Justino - SMSDC André Luís Bezerra Tavares - UFC André Silvia Walter de Aguiar - UFC Angela Helena Marin - UNISINOS Angélica  Manfroi - SBMFC Angelmar Constantino Roman - UP Armando Henrique Norman - SBMFC Augustus Tadeu Relo de Mattos - UFC Bruno José Barcellos Fontanella - UFSCar Bruno Souza Benevides - UECE Camila Giugliani - UFRGS Carla Maria Ramos Germano - UFSCar Carlo Roberto Hackmann da Cunha - PMF Carlos Alexandre Rodrigues Pereira - CEU Carlos Eduardo Aguilera Campos - UFRJ Cássio  Silveira - UNIFESP Célia Regina Machado Saldanha - FCMS/JF Celso Zilbovicius - UNIFESP César Augusto O Favoreto - UERJ César Monte Serrat Titton - PMC Charles Dalcanale Tesser - UFSC Cristina Rolim Neumann - UFRGS Cristine Vieira do Bonfim - FUNDAJ Daniel Almeida Gonçalves - UNIFESP Daniel Knupp Augusto - SMSA/BH Daniela  Dallegrave - GHC Dannielle Fernandes Godoi - UFSC David Matos Milhomens - SBMFC Débora Gusmão Melo - UFSCar Débora Modesto Barbosa - UNIFRAN Edson Iglesias Vidal - HAE Elisa Harumi Kozasa - UNIFESP Elson Romeu Farias - ULBRA Eno Dias de Castro

  2. TECHIRGHIOL - 115 YEARS OF BALNEOTHERAPY

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    SCIENTIFIC PROGRAM

    2015-06-01

    Autori: L.E. Stanciu, M. Minea, O. Surdu, V. Marin 1540 - 1600 Dr. Ionescu Valentina Elena, medic primar Recuperare, Medicină Fizică şi Balneologie doctor în Medicină, S.B.R.Techirghiol “Evaluarea efectelor nămolului sapropelic de Techirghiol asupra adipokinelor în osteoartrită” Autori: E.V.Ionescu, L. E. Stanciu, M. Minea, T.V. Surdu 1630 – 1650 Dr. Viorica Marin, medic primar Recuperare, Medicină Fizică şi Balneologie, doctor în Ştiinţe, S.B.R. Techirghiol „Efecte fiziologice şi terapeutice produse de componenta biochimică a aplicaţiei nămolului sapropelic de Techirghiol” Autori: V. Marin, L.E. Stanciu, M. Minea, O. Surdu, T.V. Surdu 1650 – 1710 Dr. Profir Daniela, medic primar Recuperare, Medicină Fizică şi Balneologie, doctor în Ştiinţe, S.B.R.Techirghiol „Efecte fiziologice şi terapeutice produse de componenta biofizică a aplicaţiei nămolului sapropelic de Techirghiol” Autori: D. Profir, L.E. Stanciu, M. Minea, O. Surdu 1710 – 1730 Conf. Univ. Dr. Olga Surdu, medic primar Recuperare, Medicină Fizică şi Balneologie, doctor în Medicină, Universitatea Ovidius Constanţa, Facultatea de Medicină, S.B.R.Techirghiol “Critical review on scientific visibility of studies realised in Balneal and Rehabilitation Sanatorium of Techirghiol” Autori: O. Surdu, M. Surdu, L.E. Stanciu, M. Minea Sunday, 29.06.2014 1000 – 1300 Session IV „Afecţiuni reumatologice – actualităţi şi perspective de tratament balnear” 1000 – 1020Drd. Minea Mihaela medic specialist reumatolog, medic specialist Recuperare, Medicină Fizică şi Balneologie, S.B.R.Techirghiol „Registrul de evidenta a pacienţilor cu boli autoimmune actualităţi şi perspective” Autori: M. Minea, D. Oprea 1020 – 1040 Dr. Oprea Doiniţa medic specialist reumatolog, doctor în Medicină, S.B.R.Techirghiol “Prezentări de cazuri clinice – pacienţi cu afecţiuni reumatologice trataţi în SBRT” Autori: D. Oprea, M. Minea 1040 – 1100 Dr. Viorica

  3. Editorial e Prefácio

    Directory of Open Access Journals (Sweden)

    Alberto Manuel Brandão Simões

    2014-07-01

    (JBCS e a  Linguamática -- Revista para o Processamento Automático das Línguas Ibéricas.Nesta edição especial da Linguamática em homenagem ao STIL 2013, trazemos três versões estendidas dos seguintes artigos publicados na edição de 2013 do STIL:Geração de expressões de referência em ambientes virtuais interativos, por Diego Silva e Ivandré Paraboni;Usando grades de entidades na análise automática de coerência local  em textos científicos, por Alison Polpeta Freitas e Valéria Feltrim;NERP-CRF: uma ferramenta para o reconhecimento de entidades nomeadas por meio de conditional random fields, por Daniela do Amaral e Renata Vieira.Aproveitamos a oportunidade para agradecer aos autores, membros do Comitê de Programa, Palestrantes Convidados, SBC e os comitês locais e gerais do STIL 2013.Desejamos a todos uma leitura proveitosa destes trabalhos!Sandra Maria AluísioValéria Delisandra Feltrim

  4. EDITORIAL: Ongoing climatic change in Northern Eurasia: justification for expedient research

    Science.gov (United States)

    Groisman, Pavel; Soja, Amber J.

    2009-12-01

    the Arctic normalized difference vegetation index D A Walker, M O Leibman, H E Epstein, B C Forbes, U S Bhatt, M K Raynolds, J C Comiso, A A Gubarkov, A V Khomutov, G J Jia, E Kaarlejarvi, J O Kaplan, T Kumpula, P Kuss, G Matyshak, N G Moskalenko, P Orekhov, V E Romanovsky, N G Ukraientseva and Q Yu Methods of surface monitoring from space A bio-optical algorithm for the remote estimation of the chlorophyll-a concentration in case 2 waters Anatoly A Gitelson, Daniela Gurlin, Wesley J Moses and Tadd Barrow Estimation of chlorophyll-a concentration in case II waters using MODIS and MERIS data—successes and challenges W J Moses, A A Gitelson, S Berdnikov and V Povazhnyy Dual scale trend analysis for evaluating climatic and anthropogenic effects on the vegetated land surface in Russia and Kazakhstan K M de Beurs, C K Wright and G M Henebry Satellite microwave remote sensing of North Eurasian inundation dynamics: development of coarse-resolution products and comparison with high-resolution synthetic aperture radar data R Schroeder, M A Rawlins, K C McDonald, E Podest, R Zimmermann and M Kueppers

  5. Proceedings - II Scientific Conferences CBIOS

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    L. Monteiro Rodrigues, et al.

    2016-12-01

    THE IN VITRO ANTI-INFLAMMATORY AND SKIN-RELATED ENZYMATIC INHIBITION ACTIVITIES OF PLECTRANTHUS SPP. EXTRACTS AND ISOLATED COMPOUNDS. Joana Marçalo, Luísa Custódio, Marisa Nicolai, Luís Monteiro Rodrigues, Catarina Pinto Reis, Célia Faustino, Patrícia Rijo P.23 EVALUATION OF GLYCATED HEMOGLOBIN (HA1C STATUS IN PATIENTS FROM AN INTERNAL MEDICINE SERVICE AT A LISBON HOSPITAL. Joana Padrão, Nelson Tavares P.24 NANOFORMULATIONS FOR THE TREATMENT OF YEAST INFECTIONS IN THE ORAL MUCOSA. Luís Roque, Catarina Garcia, Patrícia Rijo and Catarina Pinto Reis P.25 NANOCARRIERS FOR SKIN DELIVERY OF COSMETIC ANTIOXIDANTS. Mafalda Almeida,1 Patrícia Penela, Ana Júlio, André R. Baby, Daniela C. Oliveira, Catarina Rosado, Tânia Santos de Almeida,Joana Portugal Mota P.26 COMPARISON OF THE SENSORIAL PROFILES IN TWO DISTINCTIVE PERIODS OF TWO BRANDS OF CERVEJAS DE MOÇAMBIQUE, THE 2M AND MANICA. Mitchelle Carneiro, Nelson Tavares P.27 EVALUATION OF THE AMOUNT OF ADDED SALT IN COOKING MEALS IN A LISBON HOSPITAL. Nuno Rubio, Nelson Tavares

  6. Editorial

    Directory of Open Access Journals (Sweden)

    Gildenir Carolino Santos

    2014-08-01

    desenvolvido para auxiliar o processo de inclusão escolar de pessoas com paralisia cerebral. Para o desenvolvimento dessa pesquisa os autores escolheram a metodologia de estudo de caso, pois se trata de uma investigação multifacetada, em profundidade, de um único fenômeno social. O estudo sobre o Brain-Computer Interface (BCI busca aprimorar a maneira de interação entre o ser humano e as máquinas, e permite que pessoas com paralisia cerebral possam se beneficiar no processo de educação inclusiva, assim como seus colegas sem deficiência. Já no último trabalho da seção ARTIGOS, com o título “Até que ponto o bullying influencia o aumento da demanda por educação de jovens e adultos?”, os autores Márcio Jacometti (Universidade Tecnológica Federal do Paraná, Luciano Blasius (Academia Policial Militar do Guatupê – PR, Márcio José Polido (Colégio Agrícola Estadual – Santa Mariana, Murilo Martins de Andrade (Faculdade Educacional de Araucária – PR têm por objetivo descrever o processo de bullying que ocorre nas escolas como possível causa da evasão escolar e do aumento da demanda por Educação de Jovens e Adultos (EJA, observada no contexto educacional brasileiro atual, de modo a buscar uma resposta ao questionamento aventado. O artigo explora possíveis causas para a evasão e para a demanda pela EJA, e recomenda novas pesquisas para esclarecer essas questões e as consequências do processo de bullying. Na seção RELATO DE EXPERIÊNCIA, Kassiana da Silva Miguel (Universidade Federal de Santa Catarina, Iasmine Alessandra Oliveira Baracho Campos, Carla Milene Knechtel, Daniela Frigo Ferraz e Lourdes Aparecida Della Justina – estes da Universidade Estadual do Oeste do Paraná –, com o trabalho “A abordagem didático-investigativa no ensino médio: um estudo acerca do DNA”, que é o resultado de uma investigação realizada no contexto do Programa Institucional de Bolsas de Iniciação à Docência – PIBID, do subprojeto de Ci

  7. List of Participants

    Science.gov (United States)

    2007-11-01

    de Física Teórica, Madrid Aaron Sim Imperial College, London Woojoo Sim Pohang University of Science and Technology (POSTECH) Sergey Slizovskiy Department of Theoretical Physics, Uppsala University Paul Smyth Katholieke Universiteit Leuven Corneliu Sochichiu Laboratori Nazionali di Frascati Dmitri Sorokin Istituto Nazionale di Fisica Nucleare, Padova Kellogg Stelle Imperial College, London Piotr Surowka Jagiellonian University, Krakow Yasutoshi Takayama Niels Bohr Institute, København Laura Tamassia Katholieke Universiteit Leuven Radu Tatar University of Liverpool Larus Thorlacius University of Iceland Paavo Tiitola Helsinki Institute of Physics Diego Trancanelli Stony Brook University, NY Michele TraplettiInstitut für Theoretische Physik, Universität Heidelberg Mario Trigiante Politecnico di Torino Angel Uranga CERN, Geneva and Instituto de Física Teórica, Madrid Roberto Valandro SISSA, Trieste Dieter Van den Bleeken Katholieke Universiteit Leuven Antoine Van Proeyen Katholieke Universiteit Leuven Thomas Van Riet Centre for Theoretical Physics, University of Groningen Pierre Vanhove Service de Physique Théorique, Saclay Oscar Varela Universidad de Valencia Alessandro Vichi Scuola Normale Superiore di Pisa Massimiliano VinconQueen Mary, University of London John Ward Queen Mary, University of London and CERN, Geneva Brian Wecht Massachusetts Institute of Technology, Cambridge, MA Marlene Weiss Eidgenössische Technische Hochschule, Zürich and CERN, Geneva Sebastian Weiss Université de Neuchâtel Alexander Wijns Vrije Universiteit, Brussel Przemek Witaszczyk Jagiellonian University, Krakow Timm Wrase University of Texas at Austin Jun-Bao Wu SISSA, Trieste Amos Yarom Ludwig-Maximilians-Universität, München Marco Zagermann Max-Planck-Institut für Physik, München Daniela Zanon Dipartimento di Fisica, Università di Milano Andrea Zanzi University of Bonn Andrey Zayakin Moscow State University (MSU) and Institute for Theoretical and Experimental Physics (ITEP

  8. List of Participants

    Science.gov (United States)

    2008-11-01

    WyderKatholieke Universiteit Leuven Ahmed YoussefAstroParticule et Cosmologie (APC), Université Paris Diderot Daniela ZanonUniversità Degli Studi di Milano Andrea ZanziPhysikalisches Institut, Universität Bonn Andrey ZayakinInstitute for Theoretical and Experimental Physics (ITEP), Moscow Tobias ZinggUniversity of Iceland Dimitrios ZoakosUniversidade de Santiago de Compostela Emanuele ZorzanUniversità di Milano Konstantinos ZoubosNiels Bohr Institute, København

  9. Editorial

    Directory of Open Access Journals (Sweden)

    José Bernal Rivas Fernández

    2013-01-01

    bibliotecas digitales y repositorios institucionales. Lo que interesa de este trabajo es expresar la manera en que los metadatos se han ido fortaleciendo en las comunidades bibliotecarias, y señalar que la perspectiva actual es mirar hacia lo que está sucediendo en el entorno de los datos ligados como eje de trabajo de la Web Semántica. De acuerdo con el propósito de este trabajo, hay que destacar que el impacto de los metadatos en las bibliotecas ha abierto nuevas y mejores oportunidades de desarrollo; por ello, el conjunto de supuestos que desarrolla sobre el rompecabezas de los metadatos y su impacto en la catalogación así como en las bibliotecas nos invita a mirar con asombro, pero con cautela, los nuevos tiempos de oportunidad.En la sección de ensayos, Lorena Chaves Salgado presenta Una aproximación al poema “Arte Poética” de Jorge Luis Borges, en realidad, es una lectura sobre este poema. Para ello, aborda ciertos antecedentes teóricos que apoyan los planteamientos expuestos por el autor. La autora parte de la idea de que la obra de arte es una creación que encierra belleza solo por sí misma y, por eso, la obra poética es única y definida y solo puede expresarse por medio del poema mismo. De esta manera, “Arte poética”, aparecido en El hacedor en 1960, combina verso y prosa, estilo característico de un Borges maduro. Esta producción literaria constituye un punto culminante de su obra poética ya consolidada, donde expresa lo esencial que encierra la poesía, cómo se escribe y qué es la poesía.En La biblioteca escolar y las necesidades de información en temas de sexualidad adolescente, Ma. Daniela Muñoz Alvarado hace referencia al tema del papel de la biblioteca escolar ante los adolescentes y ante los nuevos Programas de Estudio de Educación para la Afectividad y la Sexualidad Integral del Ministerio de Educación Pública (MEP, con el objetivo de establecer la relación que existe entre las necesidades informacionales de la poblaci

  10. 6th International Symposium on Molecular Allergology (ISMA

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    Christiane Hilger

    2016-10-01

    -allergic humans Almedina Kurtaj, Christoph Hillebrand, Gerda Fichtinger, Martin Danzer, Christian Gabriel, Theresa Thalhamer, Sandra Scheiblhofer, Josef Thalhamer, Richard Weiss P4 Analyzing the cross-reactivity profile of the major ragweed allergen Amb a 1 Martin Wolf, Michael Hauser, Ulrike Pichler, Teresa Twaroch, Gabriele Gadermaier, Christof Ebner, Hidenori Yokoi, Toshiro Takai, Alain Didierlaurent, Adriano Mari, Peter Briza, Heidrun Behrendt, Angela Neubauer, Frank Stolz, Fátima Ferreira, Michael Wallner P5 LTP (Pru p 3 sensitisation in skin prick test: which means in clinical practice? Sara Carvalho, Tatiana Lourenço, Joana Cosme, Fátima Cabral Duarte, Amélia Spínola Santos, Ana Célia Costa, Manuel Pereira Barbosa P6 IgE profiles, allergen exposure and lifestyle of 501 Austrian pupils: investigation of influences on the development of allergic sensitizations Teresa Stemeseder, Eva Klinglmayr, Bettina Schweidler, Lisa Lueftenegger, Stephanie Moser, Patrick Doppler, Roland Lang, Martin Himly, Gertie J. Oostingh, Arne Bathke, Joerg Zumbach, Thomas Hawranek, Gabriele Gadermaier P7 Molecular profiles of sensitization to perennial inhalant allergens in a middle European region Petr Panzner, Martina Vachova, Tomas Vlas, Marek Maly P8 Evolution of the IgE response to house dust mite allergen molecules in childhood Daniela Posa, Serena Perna, Stephanie Hofmaier, Laura Hatzler, Alexander Rohrbach, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Philippe Stock, Ulrich Wahn, Linus Grabenhenrich, Thomas Keil, Susanne Lau, Kuan-Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi P9 Tropomyosin (Pen a1: to include or not to include in skin prick testing? Joana Cosme, Sara Carvalho, Tatiana Lourenço, Amélia Spínola Santos, Manuel Pereira Barbosa Immunoallergy Department - Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal, Lisbon, Portugal; Immunoallergy Department - Hospital de Santa Maria

  11. 3rd International Conference on Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    (University of South Florida, USA) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Joseph J Niemela (International Centre for Theoretical Physics, Italy) • Katsunobu Nishihara (Institute for Laser Engineering, Osaka, Japan) • Katepalli R Sreenivasan (New York University, USA) We greatly acknowledge the effort and dedication of the members of the Committee for Best Poster Award: • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Katsunobu Nishihara (Institute for Laser Engineering, Osaka, Japan) • Annick Pouquet (National Center for Atmospheric Research, USA) • Walter Gekelman (University of California, Los Angeles, USA) • Graeme Watt (Institute of Physics, UK) We greatly appreciate the work of conference web-master Daniil V Ilyin (University of Chicago, USA). We thank for technical support: • Bhanesh Akula (Texas A & M University, USA) • Ahmad Qamar (University of Chicago, USA) We warmly acknowledge the logistics assistance of the offices and officers of the Abdus Salam International Centre for Theoretical Physics: • Conference Support Office, and Ms Katrina Danforth and Ms Daniela Giombi • Financial Office, and Mr Andrej Michelcich and Ms Alessandra Ricci • Visa Office, and Mr Erich Jost and Mr Adriano Maggio • Housing Office, and Ms Tiziana Bottazzi and Ms Dora Photiou • Publications Office, and Mr Guido Comar and Mr Raffaele Corona • Computer Office, and Dr Johannes Grassberger • Science Dissemination Unit, and Dr Enrique Canessa, Dr. Carlo Fonda and Dr Marco Zennaro We gratefully appreciate the support of the members of the Programme Coordination Board: • Snezhana I Abarzhi (University of Chicago, USA) • Malcolm J Andrews (Los Alamos National Laboratory, USA) • Sergei I Anisimov (Landau Institute for Theoretical Physics, Russia) • Hiroshi Azechi (Institute for Laser Engineering, Osaka, Japan) • Vladimir E Fortov (Institute for High Energy Density, Russia) • Serge Gauthier (Commissariat à l

  12. Prikazi

    Directory of Open Access Journals (Sweden)

    Drahomira Gavranović

    2012-02-01

    odnosno zbirkama, naglašavajući odgovornost voditelja zbirke i važnost odlučivanja o prioritetima same zbirke. Stara i rijetka građa danas podrazumijeva uključivanje u projekte digitalizacije, no odgovornost je voditelja zbirke procjena što se i koliko dobiva ili gubi digitalizacijom. Autorica daje primjere uloge zbirke stare građe u sveučilišnom sustavu te mogućnosti uporabe digitalizirane građe za udaljene istraživače. Kako postupci digitalizacije u svjetlu omogućavanja pristupa digitaliziranoj građi podrazumijevaju kvalitetne metapodatke, autorica stavlja naglasak upravo na taj dio opisa digitalizirane građe. U radu se može vidjeti primjer nekoliko uspješnih projekata vezanih uz sveučilišne zbirke posebne vrste građe, poput zbirke starih američkih zemljopisnih karata. Zbornik radova s Ljetne škole o staroj knjizi iznimno je vrijedan izvor za sve koji se bave ili se žele baviti istraživanjima pisane baštine, bilo da se radi o rukopisnoj ili tiskanoj staroj i rijetkoj građi ili o digitaliziranim inačicama. Zbornik daje samo mali pregled mogućih tema i ukazuje na to da je istraživanje stare i rijetke građe interdisciplinarnog karaktera i samo suradnjom povjesničara, bibliografa, knjižničara, arhivista, povjesničara umjetnosti, muzeologa, jezikoslovaca, leksikografa, klasičnih filologa, digitalnih humanista, kemičara, računalnih stručnjaka i stručnjaka iz mnogih drugih područja možemo dobiti barem djelomičnu sliku važnosti tih interdisciplinarnih istraživanja u svrhu otkrivanja zanimljivih i važnih činjenica iz naše prošlosti koje su skrivene u staroj i rijetkoj građi. (Drahomira GavranovićAleksandra Horvat - Daniela Živković, Knjižnice i autorsko pravo.Zagreb: Hrvatska sveučilišna naklada, 2009.Djelo Knjižnice i autorsko pravo autorica Aleksandre Horvat i Daniele Živković prvo je u nas objavljeno djelo s područja autorskog i srodnih prava u području djelatnosti knjižnica, koje se može primijeniti i u drugim

  13. Apresentação - Introduction

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    RHE Asphe

    2015-05-01

    Janeiro e ligados à Medicina, a ginástica, que é tomada como domínio do saber médico. Intentam pensar a introdução da prática nas escolas brasileiras. O tema acumula um conjunto significativo de estudos da historiografia brasileira e internacional da Educação, mas importa destacar no artigo mais uma demonstração de questões amplamente discutidas sobre saberes médicos e educação a partir de uma empiria que se apresenta como observatório privilegiado da produção e legitimação dos saberes médicos.Século 20, Espanha e mobiliário escolar encontram-se tematizados no instigante artigo de Jauri dos Santos Sá que nos dá provas da vitalidade das abordagens acerca do patrimônio educativo e da cultura material escolar para a História da Educação. Examina a atuação de Josep Goday, arquiteto espanhol, como protagonista na configuração de um mobiliário que procurava dignificar a sala aula para além dos aspectos arquitetônicos e estéticos, pois este constituía um índice da modernidade pedagógica. Inversamente, podemos pensar, a partir da modernidade pedagógica, o papel desempenhado pelo mobiliário escolar, enfim, isso é para dizer que o olhar dirigido ao mobiliário pode espraiar-se e, a partir dele, pensar a complexidade de questões do período histórico e do projeto/experiência educacional em que o mesmo se inscreve. O mobiliário, segundo o autor, constitui um dos principais testemunhos da arqueologia da escola, podendo mesmo ser concebido como indicador da difusão de projetos pedagógicos e processos de modernização em educação.Início do século 20, Minas Gerais, fazendas-modelo estão tematizados no artigo seguinte, de Irlen Antônio Gonçalves e Daniela Pereira Versieux, que aborda a formação de aprendizes agrícolas nestas iniciativas educacionais que possuem um caráter ímpar e que ministraram o ensino agrícola prático a um número expressivo de aprendizes em pelo menos cinco escolas mineiras assim identificadas. Os

  14. Poster Session C

    Science.gov (United States)

    2014-01-01

    end we established a resource of SRM assays for CRL complexes and their interactors. This resource comprises assays for over 300 proteins including all cullins, their known adaptors and substrate receptors as well as known CRL regulators and E2 ligases. We will use this resource to accurately quantify changes in affinity purified CRL complexes comparing HIV-1 and mock infected cells. Additionally, infections with Vif, Vpu or Vpr deleted HIV-1 mutants will allow linking specific CRL PPIs to each of the viral proteins. For the APs we generated Jurkat T cell lines stably expressing tetracycline inducible versions of 6 tagged cullins (CUL1, CUL2, CUL3, CUL4A/B, and CUL5) and their 4 respective adapter proteins (SKP1, TCEB1, TCEB2, and DDB1). This project will provide the first comprehensive, quantitative dynamic CRL PPI network in the context of HIV-1 infection and potentially reveal new ubiquitin ligase-substrate relationships modulated by the viral proteins Vif, Vpu and Vpr. C.13 Validating Plasma-based Biomarkers for Ovarian Cancer Using Targeted Proteomics Ruth Hüttenhain1, Meena Choi2, Ching-Yun Chang2, Daniela Dinulescu3, Olga Vitek2, Emma Nimèus-Malmström4, Ruedi Aebersold5 1University of California, San Francisco, CA, USA; 2Purdue University, IN, USA; 3Dana-Farber/Harvard Cancer Institute, Boston, MA, USA; 4Lund University, Sweden; 5ETH Zurich, Switzerland The identification of protein biomarkers for early detection of ovarian cancer (OC) promises to improve management and outcome of the disease. Protein biomarker research is currently hampered by the limited availability of quantitative assays that would allow for sensitive and reproducible quantification of candidate biomarkers in complex samples such as blood plasma. In recent years selected reaction monitoring (SRM), a targeted mass spectrometric method has emerged and promises to overcome the aforementioned limitation. Here, we describe a large-scale biomarker validation study for OC using an SRM