Kroniske pulmonale aspergilloser

DEFF Research Database (Denmark)

Davidsen, Jesper Rømhild; Rosenvinge, Flemming S; Assing, Kristian

2018-01-01

Chronic pulmonary aspergillosis (CPA) is an overlooked disease category in which delay of diagnosis and treatment is associated with increased mortality. A prerequisite for prognostic optimization of CPA is an increased focus on predisposing factors and patients at risk. Diagnosis of CPA is chall...

Når Evidensen Møder Modstand

DEFF Research Database (Denmark)

Ytting, Linnea Gullviva

får vi indblik i individuelle livsvilkår og betingelser, der er med til at påvirke deres evne til at leve et motionsaktivt liv. Disse emner omhandler blandt andet ensomhed, depression, angst, kroniske smerter og den aldrende krops problemstillinger, som alle er individuelle livsvilkår der ikke kan...

Design of a Randomized Controlled Trial (RCT) Evaluating Outcome and Cost-effectiveness of a Local Case-Management Intervention of Patients Suffering from Chronic Obstructive Pulmonary Disease (COPD)

DEFF Research Database (Denmark)

Sørensen, Sabrina Storgaard; Pedersen, Kjeld Møller; Ehlers, Lars Holger

2013-01-01

Introduktion: I december 2001 igangsatte den Danske Regering en ny national strategi for håndteringen af kronisk sygdom, hvor der bl.a. blev afsat knap 100 millioner kr. til oprettelsen af nye stillinger som forløbskoordinatorer, hvis formål er at understøtte særligt sårbare patienter. Der eksist...

Mikrobiologer ser bakterier i kortene

DEFF Research Database (Denmark)

Harmsen, Morten; Sternberg, Claus; Haagensen, Janus Anders Juul

2008-01-01

at klumpe sig sammen i slimede biofilm, som især er et stort problem på hospitalerne og hos patienter med kroniske infektioner. For at kunne bekæmpe biofi lm må forskerne vide mere om, hvorfor og hvordan filmen dannes. Ny viden inden for mikrobiologien og udviklingen af nanoteknologiske mikroskoper hjælper...

Akut iskaemisk proktitis efter et epileptisk anfald

DEFF Research Database (Denmark)

Klintmann, Camille Kristine; Hillingsø, Jens; Glenthøj, Anders

2008-01-01

Acute ischemic proctitis is a rare diagnosis mainly because the rectum is supplied by an extensive arterial network. Consequently, in more than 90% of patients with ischemic colitis the rectum is spared. Previously reported cases are related to severe vascular insufficiency of the rectal circulat...... circulation caused by systemic atherosclerosis, usually following aortic or aortoiliac operations. We report one case of acute ischemic proctitis following an epileptic attack....

Serious Mental Illness and Risk for Hospitalizations and Rehospitalizations for Ambulatory Care-sensitive Conditions in Denmark:

DEFF Research Database (Denmark)

Davydow, Dimitry; Ribe, Anette Riisgaard; Pedersen, Henrik Søndergaard

2015-01-01

Antallet af akutte indlæggelser for kroniske sygdomme har i de senere år været stigende i den vestlige verden. De mange indlæggelser har medført øgede udgifter i sundhedsvæsenet, selvom nogle af disse indlæggelser potentielt kunne være undgået med forebyggelse og behandling i det nære sundhedsvæs...

Akut-i-kronisk leversvigt

DEFF Research Database (Denmark)

Ørntoft, Nikolaj Worm; Thomsen, Karen Louise; Dam, Gitte

2017-01-01

Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of liver cirrhosis, organ failure and high short-term mortality (20-80% at one month). The main precipitants are infections and excessive alcohol intake, and the mechanistic features include a high ...... level of systemic inflammation, macrophage activation and liver injury. The severity of ACLF is graded according to the number and extent of organ failures. Prognostic scores help predict mortality and support decisions on intensive treatment or futility....

Et tilfaelde af tungiasis efter rejse i Kenya

DEFF Research Database (Denmark)

Rathe, Mathias; Rafn, Aase Cederlund; Poulsen, Thorkil

2009-01-01

Tungiasis is an ectoparasitic skin disease caused by infestation by the female sand flea, Tunga penetrans. Prevalence in endemic areas may reach 83%, while it is rare in non-endemic areas. However, an increase in international travel to and from the affected regions may lead to a rise in the numb...... of cases in non-endemic countries. We present a Danish case of tungiasis contracted during a trip to Kenya....

Et tilfaelde af tungiasis efter rejse i Kenya

DEFF Research Database (Denmark)

Rathe, Mathias; Rafn, Aase; Poulsen, Thorkil

2009-01-01

Tungiasis is an ectoparasitic skin disease caused by infestation by the female sand flea, Tunga penetrans. Prevalence in endemic areas may reach 83%, while it is rare in non-endemic areas. However, an increase in international travel to and from the affected regions may lead to a rise in the numb...... of cases in non-endemic countries. We present a Danish case of tungiasis contracted during a trip to Kenya. Udgivelsesdato: 2009-Mar-2...

Myalgisk encefalopati (ME)/ Chronic fatigue syndrome(CFS) : i et historisk perspektiv

OpenAIRE

Næverlid, Camilla

2009-01-01

Sammendrag Bakgrunn: ME/CFS blir definert som en ervervet kronisk sykdom med dyptgripende fysisk og psykisk utmattelse. Sykdommen har en kompleks systemisk karakter og fører ofte til livslang funksjonshemning eller invalidisering. Den opptrer gjerne sammen med symptomer på andre sykdommer (comorbiditet). Det er en usikkerhet rundt dette syndromet - da både når det gjelder definisjon, utbredelse, etiologi og behandling. Det er ingen registrering over syndromets utbredelse verken i Norge...

Molecular Methods for Typing of Streptococcus agalactiae with Special Emphasis on the Development and Validation of a Multi-Locus Variable Number of Tandem Repeats Assay (MLVA)

OpenAIRE

Radtke, Andreas

2012-01-01

Molekylære metoder for typing av Streptococcus agalactiae med særlig vektlegging av utvikling og validering av et multi-locus variable number of tandem repeats assay (MLVA) Sammendraget: Streptococcus agalactiae eller gruppe B streptokokker (GBS) forårsaker livsfarlige infeksjoner hos nyfødte, gravide eller voksne med kroniske sykdommer. Den forårsaker også jurbetennelse i storfe. Typing av GBS gir innblikk i bakteriens epidemiologi og dens fylogenetiske slektskap. Ulike deler av bakterie...

Kronisk traethedssyndrom--et kontrolleret tvoersnitsstudie

DEFF Research Database (Denmark)

Rasmussen, A K; Nielsen, H; Andersen, V

1994-01-01

Twenty-one patients fulfilling the Center for Disease Control criteria for chronic fatigue syndrome (CFS) were examined in a controlled study. Viral antibodies and tests evaluating the immune system were investigated in the patients and in a control group of 21 sex- and age-matched individuals...

Kronisk monstrøs urinretention

DEFF Research Database (Denmark)

Thomsen, Frederik Gustav; Holm, Mette Lind

2015-01-01

to suspect urinary retention. His creatinine level was normal and he had no hydronephrosis. A renography showed equal func-tion, but prolonged bilateral outflow. The volume extracted by urethral catheter passed 15 l. Absence of hydronephrosis and normal S-creatinine level has not been described in chronic...... urinary retention of this extent. Hydronephrosis is seen, but in much smaller volume of retention. Infrequent voiding is easily diagnosed. Urinary retention should be suspected when finding median cystic processes....

To importerede tilfaelde af "West Nile fever" i Danmark

DEFF Research Database (Denmark)

Knudsen, Troels Bygum; Wilcke, Jon Torgny R; Andersen, Ove

2003-01-01

In the light of the current American epidemic, and since West Nile fever (WNF) has never previously been reported in Denmark, we describe two cases imported from Israel and Canada, respectively. WNF was diagnosed in a 46-year-old Danish tourist returning from Israel and a visiting 73-year-old Can...... infection of Canadian origin....

Antitrombotisk behandling ved iskaemisk apopleksi og transitorisk cerebral iskaemi

DEFF Research Database (Denmark)

Overgaard, Karsten; Poulsen, Tina Svenstrup; Husted, Steen E

2007-01-01

In acute ischemic stroke and transient ischemic attack (TIA), aspirin is recommended to all patients (except immediately following thrombolysis). Heparin and anticoagulant therapy using vitamin K antagonists should be avoided in the acute phase. Secondary preventive antithrombotic treatment...... includes anticoagulation in patients with cardioembolic stroke and antiplatelet agents aspirin possibly combined with dipyridamole or clopidogrel alone in patients with non-cardioembolic stroke. Other individual risks may modify this treatment regimen. Udgivelsesdato: 2007-Oct-1...

Hypotermibehandling af nyfødte med hypoksisk iskaemisk encefalopati

DEFF Research Database (Denmark)

Lando, Ane; Jonsbo, Finn; Hansen, Bo Mølholm

2010-01-01

Randomised studies have demonstrated the efficacy of hypothermia for the treatment of perinatal hypoxic-ischaemic encephalopathy (HIE) in term or late preterm infants. In August 2006, the Neonatology Department at Rigshospitalet, Copenhagen, introduced total body cooling for infants born at term...

To tilfaelde af invasive infektioner med Haemophilus influenzae type f

DEFF Research Database (Denmark)

Nielsen, Jette Dettmann; Lind, Jens Wentzel; Bruun, Britta

2009-01-01

Two cases of invasive Haemophilus influenzae type f infection are presented: a three-week-old boy with meningitis and a 62-year-old woman with arthritis and bacteremia. Since 1993 vaccination against H. influenzae type b (Hib) has been offered to Danish children. The result has been a remarkable...... decrease in invasive Hib disease. However, physicians need to be aware of the existence of non-type b invasive H. influenzae disease. Udgivelsesdato: 2009-Jan...

To tilfaelde af invasive infektioner med Haemophilus influenzae type f

DEFF Research Database (Denmark)

Nielsen, Jette Dettmann; Lind, Jens; Bruun, Brita

2009-01-01

Two cases of invasive Haemophilus influenzae type f infection are presented: a three-week-old boy with meningitis and a 62-year-old woman with arthritis and bacteremia. Since 1993 vaccination against H. influenzae type b (Hib) has been offered to Danish children. The result has been a remarkable...... decrease in invasive Hib disease. However, physicians need to be aware of the existence of non-type b invasive H. influenzae disease. Udgivelsesdato: 2009-Jan-19...

Ny behandling af kronisk hepatitis B

DEFF Research Database (Denmark)

Andersen, Ellen Sloth; Weis, Nina M

2008-01-01

Worldwide, 350 million people are infected with chronic hepatitis B. Over the last few years, it has been possible to treat chronic hepatitis B. Treatment very often consists of nucleos(t)ide analogs and in a few cases of pegylated alpha-interferon. In 2007, a new nucleoside analog, Telbivudine...

Kronisk obstipation og betydning af livsstilsfaktorer

DEFF Research Database (Denmark)

Borre, Mette; Qvist, Niels; Raahave, Dennis

2015-01-01

First-line treatment of constipation includes dietary fibre, fluid and exercise. The evidence for these recommendations is, however, scarce. Increased intake of fibre will reduce colonic transit time and improve the frequency and consistency of stools in 50% of patients. Bloating and flatulence...

MBHI hos patienter med kroniske rygsmerter

DEFF Research Database (Denmark)

Simonsen, Erik; Kastberg, S.; Jensen, Hans Henrik

1991-01-01

Studied the predictive validity of the MBHI (T. Millon et al, 1982) and analyzed the differences in personality and attitudes between patients with chronic lower-back pain and patients with acute pain. Human Ss: 26 male and female adults (aged 28–60 yrs) (chronic lower-back pain); 24 male and fem...... of treatment to determine the extent of the success of the therapy. The actual success of the therapy was compared with the predictions for success based on the MBHI results. (English abstract) (PsycINFO Database Record (c) 2012 APA, all rights reserved)...

Udredning af barnet med kronisk diare

DEFF Research Database (Denmark)

Pærregård, Anders

2011-01-01

), inflammatory bowel disease, and functional disorders (toddler's diarrhoea and irritable colon syndrome). Second line evaluation should take place in the paediatric ward, aiming to confirm suspected, complicated disorders and to explore the possibility of the large number of rare causes of CD in the seriously...

Udredning af barnet med kronisk diare

DEFF Research Database (Denmark)

Pærregård, Anders

2011-01-01

Causes of chronic diarrhoea (CD) are numerous. At the first consultation it is possible by simple means to evaluate the child for common causes and screen for the more severe ones: infection, food allergy, disaccharide malabsorption, general malabsorption (celiac disease and cystic fibrosis......), inflammatory bowel disease, and functional disorders (toddler's diarrhoea and irritable colon syndrome). Second line evaluation should take place in the paediatric ward, aiming to confirm suspected, complicated disorders and to explore the possibility of the large number of rare causes of CD in the seriously...

Kronisk obstipation og betydning af livsstilsfaktorer

DEFF Research Database (Denmark)

Borre, Mette; Qvist, Niels; Raahave, Dennis

2015-01-01

First-line treatment of constipation includes dietary fibre, fluid and exercise. The evidence for these recommendations is, however, scarce. Increased intake of fibre will reduce colonic transit time and improve the frequency and consistency of stools in 50% of patients. Bloating and flatulence...... are common side effects to highly fermentable fibres. Daily intake of 2 l of water enhances the positive effects of fibre and 30 min. exercise per day also alleviates symptoms. Conservative treatment is usually insufficient and should be supplemented with laxatives or motility enhancing drugs....

Kronisk utmattelsessyndrom. Kunnskap, aktivitet og utfordringer

OpenAIRE

Larun, Lillebeth

2011-01-01

Chronic fatigue syndrome (CFS) is a serious disease, the aetiology of which remains unknown. The disease is manifest in a number of complex symptoms involving the neurological, immunological and endocrine systems. The primary identifying symptom is postexertional fatigue, triggered by mental or physical effort. All other possible diagnoses should be excluded before a CFS diagnosis is made. CFS-patients experience different levels of disability; some are bedridden and may be lig...

Ny behandling af kronisk hepatitis B

DEFF Research Database (Denmark)

Andersen, Ellen Sloth; Weis, Nina M; Weis, Nina M

2008-01-01

Worldwide, 350 million people are infected with chronic hepatitis B. Over the last few years, it has been possible to treat chronic hepatitis B. Treatment very often consists of nucleos(t)ide analogs and in a few cases of pegylated alpha-interferon. In 2007, a new nucleoside analog, Telbivudine......, was approved to treat chronic hepatitis B. In phase II and ongoing phase III studies, Telbivudine has proven more effective than the nucleoside analog, Lamivudine, which was very often used up until recently. Udgivelsesdato: 2008-Nov-24...

Hvordan håndterer kvinder med reumatoid artrit sygdom, moderskab og arbejdsliv?

DEFF Research Database (Denmark)

Feddersen, Helle

2017-01-01

. I Studie 2B blev der fortaget deltagerobservationer og efterfølgende interviews i forbindelse med 10 af kvindernes fremmøde i planlagte ambulante sygeplejekonsultationer. Goffmans begrebsapparat vedrørende sociale roller, identitet, stigma, front- og backstage blev anvendt i en abduktiv fortolkning......Baggrund Reumatoid artrit (RA) er en kronisk, inflammatorisk sygdom, der forekommer 3 gange hyppigere hos kvinder end hos mænd. Sygdommen kan medføre hævede, stive og smertende led samt begrænsninger i forhold til fysisk udfoldelse, deltagelse i det sociale liv og nedsat psykisk velvære. Kvinder...

Demens Film

DEFF Research Database (Denmark)

Jensen, Anders Møller

2012-01-01

Vi vil skabe film til mennesker med demens – ikke film om demens sygdommen eller beretninger om livet og hverdagen med en kronisk lidelse. Filmene skal medvirke til at frembringe en behagelig stemning omkring og hos mennesker med demens, så hverdagen bliver så tryg som mulig. Filmene skal samtidig...... var at afgrænse og prioritere projektet, samt komme med anbefalinger omkring hvad der er vigtigt, i forbindelse med produktion af film målrettet mennesker med demens. Resultat af ekspertgruppen sammenfattes i denne rapport. Projektet gennemføres som et samarbejde mellem Retrospect Film...

Biofilm ved kronisk rhinosinuitis og cystisk fibrose

DEFF Research Database (Denmark)

Fisker, Jacob; Buchwald, Christian von; Johansen, Helle Krogh

2011-01-01

Microbial biofilms are known to cause persistent foreign-body infections and have recently been acknowledged as involved in more than 65% of all human infections. Microbial biofilms have been detected in chronic rhinosinusitis, and chronic rhinosinusitis is mandatory in patients with cystic...

Kronisk ileus efter iatrogen reversering af tyndtarmen

DEFF Research Database (Denmark)

Pedersen, Mark Ellebaek; Rahr, Hans B; Mahdi, Bassam

2010-01-01

We report a case of inadvertent reversal of the entire small intestine leading to severe complications and long-standing ileus. The clinical diagnosis was confirmed by magnetic resonance imaging and laparotomy. The patient was cured by surgical re-reversal of the bowel. Care should be taken to ma...... the bowel ends when multiple simultaneous bowel resections are performed....

Svaer metabolisk acidose hos en kronisk alkoholiker

DEFF Research Database (Denmark)

Sonne, Morten Egede; Rudolph, Søren Finnemann; Pott, Frank Christian

2008-01-01

Severe metabolic acidosis is associated with poor prognosis. We present a patient with profound alcohol and starvation-related combined lactic and keto acidosis (lactate = 29 mM; pH = 6.83) who made a good recovery following 18 hours of intensive care therapy. A brief summary of the proposed mech...

Prognosen for den kritisk iskaemiske underekstremitet som ikke kan revaskulariseres karkirurgisk

DEFF Research Database (Denmark)

Sørensen, S; Lorentzen, J E; Schroeder, T V

1993-01-01

were rest pain in 24 cases and gangrenous ulceration in ten. During a follow-up of eight to twenty-eight months five (15%) patients improved significantly, and complained only of claudication. Three patients, suffering rest pain, were unchanged at nine months follow-up, and 25 (74%) patients had...... that of an age- and sex-matched Danish population. The group of patients who preserved their limb could not be identified by either ankle- and toe-pressure measurements or clinical evaluation....

Mikroalbuminuri er associeret med firedobbelt risiko for iskaemisk hjertesygdom blandt hypertensive

DEFF Research Database (Denmark)

Jensen, Jan Skov; Feldt-Rasmussen, Bo F; Strandgaard, Svend

2002-01-01

INTRODUCTION: The urinary excretion of albumin is positively correlated to the presence of ischaemic heart disease and atherosclerotic risk factors in subjects with arterial hypertension. The aim of this population-based, follow-up study of hypertensive patients was to assess the predictive impact...... of a slightly elevated urinary excretion of albumin, i.e. microalbuminuria, on ischaemic heart disease. MATERIAL AND METHODS: In 1983-1984, blood pressure, the albumin/creatinine concentration ratio in a morning urine sample, total and HDL cholesterol in plasma, body mass index, and smoking habits were measured...

Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

DEFF Research Database (Denmark)

Balslev, U; Jonsbo, F; Junge, Jette

1991-01-01

Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case...

Et dansk tilfaelde af intestinal pseudomyiasis forårsaget af Eristalis tenax

DEFF Research Database (Denmark)

Rathe, Mathias; Ozeraityte, Aiste

2009-01-01

Intestinal pseudomyiasis caused by the larvae of the drone fly Eristalis tenax is sporadically reported and symptoms are varying. We report a ten-year-old boy with intermittent nonspecific abdominal pain. He noticed a larva in his stools which was later identified as the rat-tailed larva of Erist......Intestinal pseudomyiasis caused by the larvae of the drone fly Eristalis tenax is sporadically reported and symptoms are varying. We report a ten-year-old boy with intermittent nonspecific abdominal pain. He noticed a larva in his stools which was later identified as the rat-tailed larva...... of Eristalis tenax. After passing the larva his symptoms subsided. No treatment was given. We aim to register the first case of human pseudomyaisis caused by E. tenax in Denmark....

To tilfaelde af neonatal meningitis efter indførelse af nyt gentamicinregime

DEFF Research Database (Denmark)

Blaabjerg, Anne Sofie; Fenger-Grøn, Jesper; Møller, Jens Kjølseth

2016-01-01

, but both deteriorated again before the second dose. In both infants ampicillin-resistant but gentamicin-sensitive Escherichia coli was found. In one of the infants a resistant/less sensitive E. coli strain was also found in the cerebrospinal fluid. The rationale for the new dosing guidelines is discussed....

Depression and risk of hospitalisations and rehospitalisations for ambulatory care-sensitive conditions in Denmark

DEFF Research Database (Denmark)

Davydow, Dimitry S; Fenger-Grøn, Morten; Ribe, Anette Riisgaard

2015-01-01

Dette studie viser, at danskere med depression oftere end andre bliver hospitalsindlagt for kroniske sygdomme, som måske godt kunne være behandlet i det nære sundhedsvæsen uden indlæggelse. Den samme gruppe har også en højere risiko for at blive genindlagt inden for 30 dage. Resultaterne viser......, at risikoen for indlæggelse var 2,35 gange højere hos danskere med depression. Forskerne har set på de såkaldte preventable hospitalizations – altså indlæggelser, som måske kunne være undgået, hvis forebyggelse og behandling havde fungeret optimalt, herunder at patienten havde fulgt lægens anvisninger...

A View of DANIDAs Policy Note on Food Security through A Policy Coherent Lens

DEFF Research Database (Denmark)

Robertson, Aileen

2014-01-01

-usikkerhed hæmmer udvikling’ understreges det, at hvis ‘underernæring’ og ‘sult’ forveksles, findes disse synergier ikke og sparsomme resourcer spildes. I Danida`s ’Policy Note on Food Security’ nævnes det, at ‘852 million are living in hunger’, altså sult. Det er imidlertid snarere kronisk underernæring end sult...... Greener World for All (NEC)’. Faktisk peger man på, at landbrugets og fødevaresektorens primære rolle er at brødføde befolkningen ved at øge tilgængeligheden og forbruget af sikre, miljørigtige madvarer, der er i overensstemmelse med ernæringsmæssige anbefalinger og til overkommelige priser. Derfor...

Iltbehandling ved akut eksacerbation af kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

Ringbaek, Thomas; Lange, Peter; Mogensen, Torben

2008-01-01

Acute exacerbation of COPD is a major cause of hospitalisation in Denmark. Most of the patients require supplemental oxygen in the acute phase and some patients continue oxygen therapy at home after discharge. In this paper we discuss the physiological mechanisms of respiratory failure seen...... in acute exacerbations of COPD. The principles for oxygen therapy in the acute phase are described and recommendations for oxygen therapy are suggested....

Praediktorer for kroniske følger ved whiplashtraume

DEFF Research Database (Denmark)

Kasch, Helge; Kongsted, Alice; Carstensen, Tina Birgitte

2010-01-01

Prognostic factors for chronic whiplash-associated disorder (WAD) are identified. In WAD grade I-III, 50% report neck pain after one year (30% in background population). There is a female preponderance among WAD cases. 10% develop a work disability, but no gender differences are found. Age, crash......-injury distress was associated with a 2.1 OR for pain after one year and a 2.8 OR for work disability. Intense headache/neck pain and a multitude of non-painful complaints were both associated with a 3.5 to 4.0 times raised risk of work disability after a year....

Noninvasiv vurdering af fibrose ved kronisk viral hepatitis

DEFF Research Database (Denmark)

Risum, Malene; Barfod, Toke Seierøe; Lindhardt, Bjarne Orskov

2013-01-01

In chronic viral hepatitis the liver biopsy helps the clinician to decide when to start treatment and plan follow-up. However, the execution of a liver biopsy is associated with discomfort, and sampling error can lead to misinterpretation. Serum markers and transient elastography (TE) are being...

Kronisk tarmiskæmi hos en yngre patient

DEFF Research Database (Denmark)

Hansen, Lars Koch; Kammerlander, Heidi; Cecere, Stefano

2012-01-01

A 46 year-old woman presented with classic symptoms. Computed tomography-angiography and duplex ultrasonography showed stenosis of the aa. mesenteria superior et inferior. The patient was moved to a university hospital and a percutaneous transluminal angioplasty with insertion of stents was perfo......A 46 year-old woman presented with classic symptoms. Computed tomography-angiography and duplex ultrasonography showed stenosis of the aa. mesenteria superior et inferior. The patient was moved to a university hospital and a percutaneous transluminal angioplasty with insertion of stents...... was performed. She was discharged shortly after feeling well....

Ranolazin--ny behandling af kronisk stabil angina pectoris

DEFF Research Database (Denmark)

Ahlehoff, Ole; Hansen, Peter Riis

2009-01-01

Ranolazine sustained-release tablets were recently approved in the EU for chronic stable angina as add-on therapy when symptoms are not controlled with first-line agents. The mechanism of action is thought to involve inhibition of late sodium influx in the heart, which can reduce abnormalities...... of contractility and repolarisation associated with ischaemia. Ranolazine increases the exercise capacity, reduces angina, and diminishes the use of nitroglycerine. The drug has an excellent safety profile and may be a valuable addition to the treatment of chronic stable angina....

Støtte til egenomsorg ved kronisk sygdom?

DEFF Research Database (Denmark)

Vedsted, Peter; Jørgensen, Bjarne Søgaard; Rytter, Lars

2010-01-01

Self-management is part of chronic care to ensure an informed and activated patient. We scrutinised systematic literature reviews about self-care in general practice. There were effects on clinical and patient related measures and health services utilisation. Most effect was seen in interventions...... using health care professionals to provide education about action plans and medical treatment. Patient led education did not show effect on clinical outcome but on patient-related measures. We conclude that general practice should implement self-management as part of chronic care. Udgivelsesdato: 2010...

Behandling af kroniske sygdomme hos patienter med demens

DEFF Research Database (Denmark)

Pedersen, Hanne; Klinkby, Kristian Skikkild; Waldorff, Frans Borch

2017-01-01

, polypharmacy and chronic pain. Ongoing goal setting is important, and advance care planning is recommended. In general, comorbidity must be carefully and holistic assessed and managed according to each patient's general status of health and stage of dementia. As the dementia develops, focus should primarily...

Informeret samtykke i kliniske forsøg: teknikaliteter, tillid og tætte relationer

Directory of Open Access Journals (Sweden)

Sarah Wadmann

2013-11-01

Full Text Available I denne artikel undersøges kroniske patienters beslutninger om forsøgsdeltagelse og betydningen af deltagerinformation. På baggrund af et års feltarbejde på fire danske forskningsklinikker argumenterer jeg for, at de observerede patienter opererer efter andre logikker, når de tager beslutninger om at deltage i kliniske forsøg, end hvad der antages i den gældende forskningsetiske regulering. Feltarbejdet fulgte et klinisk lægemiddelforsøg og inkluderede observationer af forsøgskonsultationer; interviews med investigatorer, projektsygeplejersker, forsøgsdeltagere og virksomhedsrepræsentanter; samt en mindre spørgeskemaundersøgelse blandt de danske forsøgsdeltagere. Resultaterne indikerer, at for en gruppe af erfarne forsøgsdeltagere handler beslutningerne om forsøgsdeltagelse ikke om forsøget i sig selv, men om at opretholde en nær relation til forskningspersonalet. Disse patienter orienterer sig ikke efter deltagerinformation, men i forhold til tillidsrelationer. De agerer ikke som autonome individer, men oplever, at de er afhængige af sundhedssystemet. De udtrykker altruistiske motiver, men håber samtidig, at forsøgsdeltagelse vil give dem bedre helbredskontrol. For dem er forsøgsdeltagelse blevet en måde at leve med kronisk sygdom. Mulige implikationer af denne situation diskuteres, idet det understreges, at tillidsfulde relationer er en forudsætning både for god behandling og god forskning, men at de tætte relationer samtidig kan bevirke, at patienter bliver mindre kritiske, i forhold til hvilke forsøg de accepterer at deltage i, og at en bevidsthed om forsøgsrelaterede risici fortrænges fra forsøgssituationen.Nøgleord: informeret samtykke, deltagerinformation, deltagermotivation, kliniske forsøg, kronisk sygdom, DanmarkEnglish summary: Informed consent in clinical trials: technicalities, trust and intimate relationshipsThis article explores decisions about clinical trial participation in a group of patients

Kronisk pancreatitis og øvre gastrointestinal blødning

DEFF Research Database (Denmark)

Larsen, H C; Bak, Martin

1995-01-01

A 46 year-old woman with a history of chronic pancreatitis, upper epigastric pain and upper gastrointestinal bleeding of obscure origin is presented. A haemoductal pancreatitis was the source of bleeding due to erosion of the splenic artery with bleeding into a pancreatic pseudocyst communicating...... with the pancreatic duct. This case was special, because there was no aneurysmal dilatation of the splenic artery. This rare entity must always be considered in the diagnosis of gastrointestinal haemorrhage of obscure origin. The appropriate investigation to confirm the diagnosis is visceral angiography, if necessary...

Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E

2011-01-01

Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative...... phase of the disease. Furthermore we discuss the prognostic and ethical challenges for patients, their families and their caregivers. Finally, we summarize the current evidence for palliative treatment of dyspnoea and ways to evaluate response to treatment....

Nye sygdomsmarkører ved de kroniske myeloproliferative neoplasier

DEFF Research Database (Denmark)

Holmström, Morten Orebo; Ocias, Lukas Frans; Kallenbach, Klaus

2015-01-01

The chaperone and calcium storing protein calreticulin is coded by CALR, and newly identified mutations in CALR are found in respectively 49-70% and 56-88% of JAK2- and MPL-negative patients with essential thrombocytaemia (ET) and primary myelofibrosis (PMF). A total of 41 mutations have been...

Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E

2011-01-01

Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative ph...... phase of the disease. Furthermore we discuss the prognostic and ethical challenges for patients, their families and their caregivers. Finally, we summarize the current evidence for palliative treatment of dyspnoea and ways to evaluate response to treatment....

Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E

2011-01-01

Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative...

Tiotropium. Nyt antikolinergikum til behandling af kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

Pedersen, Steffen Thirstrup; Lange, Peter

2003-01-01

Tiotropium is a new anti-cholinergic drug with a long duration of action designed for maintenance treatment of chronic obstructive pulmonary disease (COPD). Tiotropium is the first drug specifically developed for the treatment of COPD, but it is also amongst the most expensive drugs used for this......Tiotropium is a new anti-cholinergic drug with a long duration of action designed for maintenance treatment of chronic obstructive pulmonary disease (COPD). Tiotropium is the first drug specifically developed for the treatment of COPD, but it is also amongst the most expensive drugs used...... for this condition. The clinical pharmacology of tiotropium and results from published controlled clinical trials are reviewed. It is concluded that tiotropium seems suitable as a symptomatic treatment for patients with moderate to severe COPD (typically a forced expiratorical volume FEV1 predicted...

Leishmaniasis isoleret til larynx som årsag til kronisk laryngitis

DEFF Research Database (Denmark)

Kaltoft, Mikkel; Munch-Petersen, Helga Richert; Møller, Henrik

2010-01-01

Mucosal leishmaniasis is uncommon outside Central and South America, where it is commonly caused by Leishmania (L.) braziliensis. We present a case of isolated laryngeal leishmaniasis detected in a 78-year-old male, who presented with chronic hoarseness. Histologic examination of biopsies taken...

Anæstesi til patienter med kroniske sår

DEFF Research Database (Denmark)

Hjort, Mathias; Hyllested, Mette; Jørgensen, Bo

2015-01-01

Perioperative management of chronic wounds demands a multidisciplinary approach. Severe co-morbidities leave these patients prone to post-operative complications. To optimize wound healing, minimally invasive methods, both surgical and anaesthesiological, are applied. Ultrasound-guided peripheral...... nerveblocks (PNB) are an ideal anaesthesia method for wound revisions, amputations and split skin transplantations. The implementation of PNB allows continued anticoagulant treatment, provides post-operative analgesia, lowers opioid consumption and facilitates mobilization....

Nye molekylaere markører ved de kroniske myeloproliferative sygdomme

DEFF Research Database (Denmark)

Larsen, Thomas Stauffer; Pallisgaard, Niels; Christensen, Jacob Haaber

2006-01-01

The Philadelphia-negative chronic myeloproliferative disorders feature autonomous myeloid hyperproliferation and hypersensitivity to a number of growth factors, which most recently have been shown to be explained by a guanine-to-thymidine mutation in the Janus tyrosine kinase (JAK2) gene, implica...

Abdominale aortaaneurismers naturhistorie med og uden coeksisterende kronisk obstruktiv lungelidelse

DEFF Research Database (Denmark)

Lindholt, J S; Heickendorff, L; Antonsen, S

1999-01-01

The relationship between abdominal aortic aneurysms (AAA) and chronical obstructive pulmonary disease (COPD), and in particular the suggested common elastin degradation caused by elastase and smoking was analysed by a cross sectional population mass screening study for AAA, and a prospective cohort......-users compared to 2.6 in non-steroid-users (p elastin-peptides (SEP) and P-elastase-alpha1-antitrypsin-complexes (PEAC) were negatively correlated to FEV1 in COPD-patients. However, SEP, beta-agonist-treatment, and FEV1 was positively correlated to expansion by multivariate regression analysis, while...

Status og perspektiver for behandling af de kroniske myeloproliferative neoplasier

DEFF Research Database (Denmark)

Ocias, Lukas Frans; Holmström, Morten Orebo; Riley, Caroline Hasselbalch

2015-01-01

of these malignancies has focused on lowering their inherent thromboembolic risk but with the discovery of the JAK2-V617F mutation and most recently the calreticulin mutations new therapeutic options such as interferon-alpha, JAK2-inhibitors and statins are being contemplated. This article reviews these new treatment...

Kroniske lungeforandringer hos børn med langvarig produktiv hoste

DEFF Research Database (Denmark)

Foghsgaard, Jakob; Nir, Marta; Marthin, June K

2009-01-01

A productive (sounding) cough is always abnormal, and suppurative lung disease should be considered. A chronic suppurative cough may be associated with the destruction of the bronchial wall (bronchiectasis). The most commonly identifiable cause of suppurative cough is cystic fibrosis. This article...

Forløbskoordinering for kronisk syge og kræftpatienter

DEFF Research Database (Denmark)

Wulff, Christian; Søndergaard, Jens; Olesen, Frede

2010-01-01

Care coordination is a superordinate term for terms related to the optimization of care for people suffering from chronic diseases and cancer. In this article, we present Danish terms for »disease management programme« and »case management« among others, and effects are summarized. The central Da...

Udviklingen i dødelighed, incidens og letalitet af iskaemisk hjertesygdom i Danmark 1982-1992

DEFF Research Database (Denmark)

Osler, M; Sørensen, Thorkild I.A.; Sørensen, S

1997-01-01

(NIHD, ICD8 codes 410-4) and broadly defined IHD (BIHD, ICD8 codes 410-4, 427 & 795-6) were calculated for the period 1982 through 1992. During the entire period the age-standardized mortality of AMI, NIHD and BIHD decreased in both men and women. The incidence of AMI and NIHD decreased, while...

Hjemtagning af dialysebehandling til grønlandske patienter med kronisk nyresvigt

DEFF Research Database (Denmark)

Kronborg, Christian; Kjær, Trine; Bech, Mickael

en periode på 10 år forventes at medføre ekstraomkostninger på ca. 13,9 millioner kroner sammenlignet med at lade patienterne behandle som nu på Rigshospitalet i København. Det vil altså sige en gennemsnitlig ekstraomkostning på ca. 4 millioner kroner om året. Estimatet er dog påvirkeligt at flere...

Medfødt malrotation som årsag til kroniske anfaldsvise abdominalsmerter

DEFF Research Database (Denmark)

Edling, Poul; Tøttrup, Anders

2014-01-01

Intestinal malrotation occurs during foetal development when the normal rotation and fixation of the midgut fails to take place. This condition may lead to volvulus and duodenal obstruction. It is almost exclusively a paediatric diagnosis, but it can become symptomatic much later in life. A 49-year...

Evaluering af tre projekter i Socialstyrelsens Forældreprogram - Resultatresumé

DEFF Research Database (Denmark)

Andersen, Luna Kragh; Scavenius Sonne-Schmidt, Christoffer

2018-01-01

ADHD og ADHD-lignende udfordringer er nogle af de mest udbredte former for psykiske proble-mer hos børn og unge (Dick & Ferguson, 2015). Forskning finder, at diagnosen kan stilles hos mindst 5 pct. af en børneårgang, hvilket svarer til 1-2 børn i hver skoleklasse (Polanczyk m.fl., 2007, 2014......; Thomas m.fl., 2015; Willcutt, 2012). Samtidig er ADHD og ADHD-lignende udfordrin-ger forbundet med negative konsekvenser, som har både en personlig pris og en samfundsmæs-sig pris, som fx behov for ekstra støtte i skolen eller særlige skoletilbud, forøget brug af sundhedsydelser og sociale ydelser og...... arbejdsmarkedet, et problempræget forhold til egne børn samt angst, depression og tidlig død (Loeber & Burke, 2011; Skogen & Torvik, 2013). I dag betragtes ADHD som en langvarig eller kronisk sygdom, men mestringsfremmende indsatser kan hjælpe forældre, børn og unge til bedre at håndtere symptomer på ADHD samt...

Prognostisk vaerdi af N-terminal pro B-type natriuretisk peptid hos patienter med stabil iskaemisk hjertesygdom--sekundaerpublikation

DEFF Research Database (Denmark)

Kragelund, Charlotte B; Grønning, Bjørn Aaris; Køber, Lars

2006-01-01

for patients with NT-proBNP levels in the fourth quartile as compared with those in the first quartile was 2.4 (95% CI 1.5-4.0). NT-proBNP provides prognostic information on all-cause mortality independent of conventional cardiovascular risk factors and left ventricular dysfunction. Udgivelsesdato: 2006-Feb-13...

Manipulation af hvirvelsøjlen ved kronisk rygsmerte--en gennemgang af et Cochranereview

DEFF Research Database (Denmark)

Bendix, Tom

2011-01-01

A new Cochrane review based on 26 studies - 18 new since the last Cochrane review from 2003 - on spinal manipulation for chronic low back pain has been published by Rubinstein et al. Generally, manipulation for these patients was not clinically relevant better than other treatments like e.g. phys.......g. physical training. In general, the widespread use of manipulation should be reduced. The issues of specific subgroups with possible relevance/irrelevance of such treatment to obtain short-lasting pain relief in selected cases are discussed....

Kvaliteten af diagnostik og behandling af kronisk obstruktiv lungesygdom i almen praksis--sekundaerpublikation

DEFF Research Database (Denmark)

Lange, Peter; Rasmussen, Finn Vejlø; Borgeskov, Hanne

2008-01-01

We investigated whether the quality of management of COPD in general practice could be improved by the participation of general practitioners and their staff in a COPD-specific educational programme. One-hundred and fifty-four doctors participated in the study, and 2549 patient record forms were...... included in the first audit and 2394 in the second audit. We observed a significantly increased utilisation of spirometry from the first (52.7%) to the second audit (71.4%) (p quality of management. We conclude that participation in an educational...... programme can improve the quality of COPD care in general practice....

Spiseoliers effekt på blodlipider og risiko for iskaemisk hjertesygdom med saerlig fokus på olivenolie. En litteraturgennemgang

DEFF Research Database (Denmark)

Jespersen, L; Jakobsen, M U; Hasseldam, Henrik

2001-01-01

The European Union is financing a large-scale campaign, in which olive oil is represented as the optimal fat for dietetic prevention of coronary heart disease.......The European Union is financing a large-scale campaign, in which olive oil is represented as the optimal fat for dietetic prevention of coronary heart disease....

Ballondilatation af det eustakiske rør er ny behandling til kronisk otitis media

DEFF Research Database (Denmark)

Møller, Martin Nue; Wanscher, Jens; Larsen, Per Leganger

2014-01-01

Balloon dilation of Eustachian tube is a novel method for managing chronic ventilatory dysfunction in patients with chronic otitis media, as an alternative to classic grommet insertion. Although few retrospective studies have been conducted the method seems to be rapid, simple and safe...

Neuromuskulær elektrostimulation forbedrer funktionsniveauet ved meget svær kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

Al-Gibouri, Salam; Ringbæk, Thomas; Lange, Peter

2013-01-01

Muscle atrophy and exertional dyspnoea are common in patients with severe chronic obstructive pulmonary disease (COPD). Neuromuscular electrical stimulation (NMES) is a new type of training for these patients. A number of randomized trials show that NMES has a positive physiological and clinical...

Ballondilatation af det eustakiske rør er ny behandling til kronisk otitis media

DEFF Research Database (Denmark)

Møller, Martin Nue; Wanscher, Jens; Larsen, Per Leganger

2014-01-01

Balloon dilation of Eustachian tube is a novel method for managing chronic ventilatory dysfunction in patients with chronic otitis media, as an alternative to classic grommet insertion. Although few retrospective studies have been conducted the method seems to be rapid, simple and safe with promi......Balloon dilation of Eustachian tube is a novel method for managing chronic ventilatory dysfunction in patients with chronic otitis media, as an alternative to classic grommet insertion. Although few retrospective studies have been conducted the method seems to be rapid, simple and safe...

Kronisk obstruktiv lungesygdom fører til stort forbrug af sundhedsudgifter og sociale udgifter

DEFF Research Database (Denmark)

Jensen, Martin Bach; Fenger-Grøn, Morten; Fonager, Kirsten

2013-01-01

INTRODUCTION: The present study compared health carerelated costs and the use of social benefits and transfer payments in participants with and without chronic obstructive pulmonary disease (COPD), and related the costs to the severity of the COPD. MATERIAL AND METHODS: Spirometry data from...... a cohort study performed in Denmark during 2004-2006 were linked with national register data that identified the costs of social benefits and health-care services. The cohort comprised 546 participants with COPD (forced expiratory volume in the first sec. (FEV1)/forced vital capacity (FVC) ratio ... of disability pensions. CONCLUSION: Health care-related costs and costs for social benefits and transfer payments were higher for participants with COPD than for non-COPD participants and nonresponders. FUNDING: This study was supported by The Obel Family Foundation, The Danish Lung Association and The Health...

Høj fysisk aktivitet ved kronisk obstruktiv lungesygdom er en vigtig del af behandlingen

DEFF Research Database (Denmark)

Rugbjerg, Mette; Lange, Peter; Iepsen, Ulrik Winning

2016-01-01

High physical activity is important in chronic obstructive pulmonary disease treatment Patients with chronic obstructive pulmonary disease (COPD) have lower activity levels than healthy controls. Loss of skeletal muscle affects COPD negatively, and strengthening of the musculature is probably part...... of the explanation for the positive effects of physical activity. This review de­scribes the recent literature on restoring and maintaining physical activity in COPD and the importance of maintaining high physical activity levels. Furthermore, the future per­spectives for research in COPD, physical activity...

Neuromuskulær elektrostimulation forbedrer funktionsniveauet ved meget svær kronisk obstruktiv lungesygdom

DEFF Research Database (Denmark)

Al-Gibouri, Salam; Ringbæk, Thomas; Lange, Peter

2013-01-01

effect of muscle strength and endurance in patients with advanced COPD and in patients with acute COPD exacerbations. However, this positive effect is not seen in patients with moderate COPD. We suggest that NMES should be integrated in rehabilitation programmes for patients with severe COPD.......Muscle atrophy and exertional dyspnoea are common in patients with severe chronic obstructive pulmonary disease (COPD). Neuromuscular electrical stimulation (NMES) is a new type of training for these patients. A number of randomized trials show that NMES has a positive physiological and clinical...

Forudsigelse af udviklingen i dødelighed af iskaemisk hjertesygdom i Danmark 1982-1991 ved anvendelse af simulationsmodellen Prevent

DEFF Research Database (Denmark)

Brønnum-Hansen, Henrik; Sjøl, A

1996-01-01

Population Studies). Relative risk estimates are those implemented in the Dutch version of Prevent based on international literature. The risk factors are: tobacco smoking, hypertension, cholesterol, and alcohol consumption. Results are given for ages below 65 years. The pronounced decline in mortality......The simulation model "Prevent" estimates the effect on mortality of changes of exposures to risk factors taking the multifactorial nature of the associations between risk factors and diseases, time dimensions, and demography into account. The objective of the study is to compare the actual...... of ischaemic heart disease in Denmark cannot be foreseen by the model based on the development of the associated risk factors. However, the combined trend of risk factors for the last 10 to 15 years is only modest and does not indicate the dramatic decline in mortality. Prevent is too simple to make...

Fedme og risiko for marginal parodontitis

DEFF Research Database (Denmark)

Kongstad, Johanne; Keller, Amélie Cléo; Rohde, Jeanett Friis

2017-01-01

Oversigtsartiklen, der er af narrativ karakter, beskriver sammenhængen mellem overvægt/ fedme og marginal parodontitis. Artiklen er baseret på et udvalg af nyere engelsksproget litteratur og motiveres af den øgede forekomst af overvægtige og fede i befolkningen. Desuden er det afgørende, at tandl......Oversigtsartiklen, der er af narrativ karakter, beskriver sammenhængen mellem overvægt/ fedme og marginal parodontitis. Artiklen er baseret på et udvalg af nyere engelsksproget litteratur og motiveres af den øgede forekomst af overvægtige og fede i befolkningen. Desuden er det afgørende......, at tandlæger forholder sig kritisk til systemiske tilstandes mulige konsekvens for udvikling, forværring og behandling af marginal parodontitis. Der nævnes forskellige mål for fedme, hvor body mass index (BMI) og taljeomkreds er de mest anvendte. Problematikken vedrørende tidligere studiers anvendelse af...... forskellige kriterier for marginal parodontitis berøres. Litteraturgennemgangen tager udgangspunkt i de biologiske mekanismer, der udløses i fedtvæv ved overvægt/fedme og medfører en kronisk inflammatorisk tilstand med frigivelse af bl.a. adipokiner. Epidemiologiske tværsnitsog longitudinelle studier af...

Rektovesikal fistel som komplikation i forbindelse med endoskopisk vakuumbehandling af kronisk præsakral kavitet

DEFF Research Database (Denmark)

Nerup, Nikolaj; Bulut, Orhan

2013-01-01

A 66-year-old male who underwent Hartmann's operation for rectal cancer developed a pelvic abscess treated with late onset endoscopic vacuum (endo-VAC). He developed a fistula from the abscess to the bladder. The literature does not support prolonged or late onset endo-VAC to treat chronic pelvic...... abscesses. There is only evidence for early treatment of the presacral abscess. To prevent fistula formation during endo-VAC, care should be taken if the abscess-cavity is close to the bladder or the sponge is in direct contact with other bowel segments. Magnetic resonance imaging with contrast enema can...

En krobjektiv lidelse? Forståelse og behandling af kroniske, diffuse smertelidelser med fibromyalgi som eksempel

Directory of Open Access Journals (Sweden)

Rie Lykke Danielsen

2011-12-01

Full Text Available The article deals with the disease field chronic diffuse pains, here exemplified by fibromyalgia, where patients are frequently rendered homeless in an objectivity focused medical treatment system, whose specialities (ideally seen are mutually exclusive, and where the absence of a diagnosis therefore poses a fundamental problem. In the treatment field there is, however, also a bio-psycho-social approach, and these two treatment regimes are respectively termed as a chrObjective approach and a holistic subject approach.By empirical examples, from stories by both therapists and patients, the article describes how the actors navigate between the two treatment regimes, to which the patients must necessarily adapt in their wish for acceptance and assistance from both sides. The authors further discuss to which degree the two treatment regimes are actually incompatible. The interviews and observation of participants, which constitute the empirical basis for the article, were carried out among therapists and patients in Denmark in 2010.

Læger bør øge fokus på medicinadhærens blandt kronisk syge

DEFF Research Database (Denmark)

Tøttenborg, Sandra Søgaard; Topp, Marie; Ingebrigtsen, Truls Sylvan

2014-01-01

outcomes. Yet, no "gold standard" for assessing adherence and no consensus on what is an acceptable level exist. Physicians should be aware of non-adherence and, although it may not always be identical with the evidence-based regimen, they can facilitate good adherence by simplifying regimens and adapting...

Måling af lungefunktion hos patienter indlagt med akut forvaerring af kronisk obstruktiv lungesygdom eller astma

DEFF Research Database (Denmark)

Lange, Peter; Rasmussen, Lisbeth Kappelgaard; Said, Nihaya Mahmoud

2005-01-01

Acute exacerbation of COPD or asthma leads to many acute hospital admissions every year. Even though the pathogenesis of these diseases differs, in both cases the cardinal manifestation is increased airway obstruction, which can be measured using peak expiratory flow measurement (PEF......) or measurement of forced expiratory volume in one second (FEV1)....

Kronisk inflammatorisk tarmsygdom hos børn. En epidemiologisk opgørelse fra østdanmark 1998-2000

DEFF Research Database (Denmark)

Urne, Frederikke Uldall; Paerregaard, Anders

2002-01-01

INTRODUCTION: The purpose of this retrospective study was to investigate the epidemiology and anthropometrical status in children and adolescents with chronic inflammatory bowel disease in Denmark during the period 1998-2000. MATERIAL AND METHODS: Patients from the eastern part of Denmark below 15...... of Crohn's disease patients with growth retardation was found. Undernutrition was also common among children with Crohn's disease. Eighty-three percent had an age-related BMI below the 50-percentile. DISCUSSION: Compared to an earlier Danish investigation, the incidence of Crohn's disease had risen 11-fold...

Vigtigheden af epidemiologiske prædiktorer for sundhedsforbrug for kroniske patienter:Et casestudie af osteoporotiske fraktur patienter

OpenAIRE

Hansen, Louise

2016-01-01

SUMMARYHealthcare systems around the world continue to see their expenditures increase, measured as a percentage of gross domestic product. Within health economics, the need for models that can predict healthcare costs is of substantial importance, as decisions to introduce as well as to decommission healthcare services are based on these. This dissertation is an attempt to highlight the importance of epidemiological factors for health economic research on chronic diseases. Hence, the researc...

Sør-Trøndelag Aktivitets-Relaterte Tiltak (START – Samhandling for bedre helse

Directory of Open Access Journals (Sweden)

Tommy Aune Rehn

2011-08-01

Full Text Available Høy forekomst av kroniske sykdommer og stigende helseutgifter representerer i lys av den kommende eldrebølgenen stor samfunnsøkonomisk utfordring. Den negative helseutviklingen er i ferd med å bli et nasjonalt problem og må få konsekvenser for fremtidig norsk helsepolitikk. Fysisk inaktivitet er en livsstilsfaktor som er sterkt assosiert med lavt nivå av kondisjon, total dødelighet og død av hjerte- og karsykdom. Studier viser at selv en liten bedring i kondisjon forventes å gi betydelig økt forventet levealder og at individer som har et bra kondisjonsnivå har opptil 15 flere leveår med god helse hvor de er selvhjulpne. Økt fysisk aktivitet har en gunstig effekt på alle risikofaktorer for kronisk sykdom og tidlig død, og vi mener derfor at man bør legge til rette for å øke det generelle fysiske aktivitetsnivået i befolkningen og bedre kunnskapen om fysisk aktivitet. Økt fysisk aktivitet vil forventes å bedre folkehelsen ved å redusere sykdomsforekomst, medisinbruk og dødelighet samt øke arbeidsevnen i populasjonen, noe som igjen vil redusere de samfunnsøkonomiske utgiftene. For å lykkes med dette, har vi tatt initiativ til prosjektet ”Sør-Trøndelag Aktivitets-Relaterte Tiltak” (START, som er tenkt å være en koordinert populasjonsbasert samhandling for bedre helse gjennom økt fysisk aktivitet rettet mot alle lag i befolkningen, fra krybbe til grav. Målet er at START skal danne grunnlag for nasjonal implementering av tiltak slik at vi oppnår en helsepolitisk bærekraftig utvikling i årene som kommer. Denne artikkelenbeskriver START og bakgrunnen for prosjektet.Rehn TA, Rognmo Ø, Ingebrigtsen JE, Vik JT, Wisløff U. Sør-Trøndelag Activity-Related Trial (START –Cooperation for better health. Nor J Epidemiol 2011; 20 (2: 209-216.ENGLISH SUMMARYHigh incidence of chronic diseases and rising health expenditure represents in light of the increasing proportion of elderly in our society a development that cannot

Overset spin-out-fænomen som årsag til kroniske smerter hos patient med totalknæalloplastik

DEFF Research Database (Denmark)

Bostadløkken, Ingvild; Tengberg, Peter Toft

2013-01-01

We present a case of a 66-year-old woman who had a total knee arthroplasty. Shortly after surgery a 90° rotation of her polyethylene liner took place. The complication was undiagnosed for 1.5 years. To know this problem and be able to diagnose it is crucial for doctors, who come in contact...

Langtidsbehandling med spinal cord-stimulation hos en patient med kronisk regionalt smertesyndrom type 1 og fantomsmerter efter amputation

DEFF Research Database (Denmark)

Enggaard, Thomas P.; Scherer, Christian; Nikolajsen, Lone

2008-01-01

The development of stump and phantom pain after limb amputation in patients with complex regional pain syndrome (CRPS) is very frequent. Stump pain is typically recurred CRPS and the possibilities for effective pharmacological pain relief are often limited. Spinal cord stimulation (SCS) has a well......-documented pain relieving effect in patients with CRPS. This case story summarises the long term effect of SCS in a patient with CRPS after two amputations of the right leg. Pharmacological pain therapies as well as Guanethidine blockade were found to be ineffective. Udgivelsesdato: 2008-Feb-4...

Angiotensin I konverteringshaemmeren enalapril til behandling af progredierende kronisk nefropati. En åben randomiseret kontrolleret undersøgelse

DEFF Research Database (Denmark)

Kamper, A L; Strandgaard, S; Leyssac, P P

1993-01-01

In order to study the influence of angiotensin converting enzyme (ACE) inhibition on the progression of chronic nephropathy, 70 patients with a median glomerular filtration rate (GFR) of 15 (range, 6 to 54) mL/min/1.73 m2 were randomised in an open study to basic treatment with enalapril or conve...

Nettfrekvente elektromagnetiske felt og helseeffekter

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Karl Gerhard Blaasaas

2009-10-01

Full Text Available I denne artikkelen oppsummeres epidemiologisk kunnskap om mulige helseeffekter etter eksponering for nettfrekvente (50/60 Hz elektromagnetiske felt. Vi har basert oss på et flertall av vitenskapelige arbeider publisert i perioden 2001-2004 og konklusjoner i rapporter og oversiktsartikler fra perioden før 2001. Det er ikke funnet noen etiologisk sammenheng mellom elektromagnetiske felt og kronisk sykdom. Man vet heller ikke sikkert hvilke egenskaper ved de elektromagnetiske feltene som eventuelt kan fremskaffe sykdom. Eventuell latenstid fra eksponering til sykdomsutvikling er også ukjent. Eksponering over 0,4 mT fra kraftlinjer ser ut til å kunne gi en dobling i risikoen for barneleukemi, og basert på metaanalyser kan ikke resultatene avvises som tilfeldige funn. Holdepunktene for en slik sammenheng er likevel begrenset. Ved vokseneksponering har man i enkeltstudier observert risikoøkninger for brystkreft, leukemi, hjernesvulst og amyotrofisk lateralsklerose. Det er også gjort isolerte funn av abort blant kvinner eksponert under graviditeten. For alle disse endepunktene er funnene allikevel ikke tilstrekkelige til å trekke sikre konklusjoner om sammenheng med eksponeringThis review is based on epidemiologic literature in the period 2001-2004 and conclusions in reports and review articles before 2001, regarding power frequency (50/60 Hz electromagnetic fields and health outcomes. Twotimes increased risks for childhood leukaemia have been observed among children exposed to magnetic fields above 0.4 mT from power lines, and based on meta-analyses these results can not be regarded as chance alone. The evidence for an association is however, still limited. Increased risks of breast cancer, leukaemia, braintumor and amyotrophic lateral sclerosis have been observed in isolated studies. Increased risk of spontaneousabortion among women exposed during pregnancy has also been reported. None of the observations for any ofthese endpoints are

Assisteret hjemmebehandling af eksacerbation i kronisk obstruktiv lungesygdom. Fremskyndet udskrivelse til fortsat behandling, monitorering og pleje i eget hjem varetaget af lungesygeplejerske

DEFF Research Database (Denmark)

Ringbaek, Thomas Jørgen; Eriksen, Nanna; Vestbo, Jørgen

2003-01-01

of COPD. In order to evaluate various types of assisted home care, the selection of patients, feasibility, effect, safety, and cost-effectiveness, the literature was reviewed. Most information is available on assisted home care following a hospital-based assessment and led by a respiratory nurse...

Immunsystemet ved kronisk inflammationTumor necrosis factor-alpha binding capacity and anti-infliximab antibodies measured by fluid-phase radioimmunoassays as predictors of clinical efficacy of infliximab in Crohn's disease

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Bendtzen, K.

2008-01-01

reactions with other cell types in vessels and organs, frequently with superimposed autoreactive T-cells and autoantibody-producing B-cells/plasma cells. The processes are distinguished on the basis of clinical manifestations in organ-specific and systemic inflammatory diseases. The underlying factors...

Rusmiddelbruk og dødelighet

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Ingeborg Rossow

2009-10-01

Full Text Available  SAMMENDRAGBruk og misbruk av rusmidler øker risikoen for en tidlig død. Blant kroniske alkoholmisbrukere er overdødelighetenpå omkring 2-3, og størst overdødelighet finner vi mht. levercirrhose, kreft i øvre deler av fordøyelseskanalen,selvmord og ulykker. Akutt beruselse har spesielt betydning for ulykkesdødsfall som drukning ogtrafikkulykker. Epidemiologiske studier har vist at moderat alkoholkonsum gir en redusert risiko for hjertekardødelighetsammenliknet med avholdenhet (en J-formet risikokurve. Disse funnene reiser en viktig debattomkring implikasjonene for folkehelse.På aggregert nivå gir en økning i alkoholkonsumet en beskjeden effekt på samlet dødelighet, men for alkoholrelatertesykdommer, ulykker og selvmord ser man betydelige effekter av endringer i gjennomsnittskonsumet.Stoffmisbrukere har en høyere overdødelighet enn alkoholmisbrukere (RR omkring 5-30, og de vanligstedødsårsakene er overdoser, selvmord og ulykker. Bruk og misbruk av alkohol er betydelig mer utbredt i befolkningenenn narkotika, og størstedelen av rusmiddelrelaterte dødsfall kan knyttes til alkohol. Det er imidlertidusikkert om dette gjenspeiles i opinionen og som argument ved politiske beslutninger og ressursallokeringer.Rossow I. Alcohol, drugs and mortality. Nor J Epidemiol 1996; 6 (1: 37-44. ENGLISH SUMMARYUse and abuse of intoxicants increase the risk of premature death. Among chronic alcohol abusers the excessmortality is in the range of 2-3. Tthe highest excess mortality is found with respect to liver cirrhosis, cancer inthe upper digestive tract, suicide and accidents. Acute intoxication also increases the risk of premature death,particularly drowning and traffic accidents. Epidemiological studies have demonstrated a lower risk of deathfrom CHD among light and moderate drinkers as compared to abstainers (the J-shaped curve. These findingshave induced an important debate concerning public health implications. At the aggregate level an

The localization of the larvae of the nostril fly (Cephenemyia trompe L in the pharynx of reindeer in an earlier unknown tonsil tissue

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Claes Rehbinder

1983-05-01

: Lokalisationen av svalgkormflugans (Cephenemyia trompe L larver i svalget på ren undersøktes. Resultaten av undersokningen visade att någon preformerad svalgficka inte forekommer hos ren, utan att på den plats dår fickor innehållande larver vanligtvis påvisas år belågen en oparig tonsillvåvnad, forslagsvis kallad Tonsillapbaryngis dorsomedialis. Hos djur infekterade med svalgkormlarver forelåg i april de fiesta fickbildningarna i anslutning till tonsillvåvnaden men fickor forekom också hoger- och vånstersidigt i svalgslemhinnan. I ett fall påvisades två fickor, en i tonsillvåvnaden och en hogersidigt i svalgslemhinnan. Fickornas vågg utgjordes vid denna årstid av en akut ej slemhinneforsedd granulationsvåvnad rikligt infiltrerad med eosinofila leukocyter. Hos novemberrenarna påvisades lsta stadiets larver av C. trompe i tonsillens kryptor. Hos en åldre ren forelåg omedelbart vid sidan av tonsillen en fickbildning, vars vågg besto av kronisk granulationsvåvnad beklådd med slemhinna. Tonsillvåvnadens roll som predilektionsplats for larvernas utveckling diskuteras.

Helseeffekter av byluftpartikler

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Magne Refsnes

2009-10-01

the observed effects. More knowledge about adverse health effects induced by low concentrations of PM and the critical particle characteristics, is required.10 (PM £ 10 mm, PM2,5 (PM £ 2,5 mm og PM0,1 (PM £ 0,1 mm. Nyere befolkningsstudier viser en assosiasjon mellom økning i dødelighet og sykelighet (pga. lunge- og hjertekarsykdommer og kortvarige økninger i svevestøvskonsentrasjoner i byluft. Den relative risikoen (RR er rundt 1,005 ved en økning av PM10 på 10 mg/m3, uten noen observert terskelverdi, selv ved nivåer under 10 mg/m3. Kronisk eksponering for svevestøv er mindre undersøkt, men årelang eksponering for PM2,5 er assosiert med en RR som er omlag 10 ganger større enn ved korttidseksponering. Befolkningsstudiene indikerer at enkelte grupper synes å være spesielt følsomme (lungesyke, hjertesyke og barn. Hos frivillige individer i kammer- og feltstudier, fant man effekter både i luftveiene og i hjerte-karsystemet ved konsentrasjoner av svevestøv (PM2,5/PM10: 100-200 mg/m3 som kan forekomme i episoder med økt luftforurensning. Dyreforsøk med høyere konsentrasjoner ga kraftigere responser. De eksperimentelle studiene understøtter befolkningsstudiene i at byluftpartikler representerer et helseproblem. Både befolkningsstudiene og eksperimentelle studier indikerer at enkelte individer er mer sårbare enn andre. Ved lave til middels konsentrasjoner av byluftpartikler synes det å foreligge en diskrepans mellom disse studietypene som kan skyldes at de mest sårbare individene ikke er inkludert i eksperimentelle forsøk. Studier med mennesker, dyr og celler viser at fysisk/kjemiske egenskaper ved partiklene (størrelse, innhold av metaller, organiske forbindelser, endotoksiner etc. er sentrale for de observerte effektene av svevestøvet. Mer kunnskap både om helseeffekter ved lave konsentrasjoner, samt egenskaper ved partikler, er nødvendig.

Brukermønster for østrogen i og etter overgangsalderen i Norge

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Kjersti Bakken

2009-11-01

a considerable increase in the sale of non-contraceptive estrogens inNorway during the last ten years. We wanted to assess the prevalence of HRT in Norwegian women 45-64 yearsand examine factors related to use.Vi finner at brukerprevalens økte med 4% fra 1996 til 1997, og bruksmønster for østrogen rundtovergangsalderen synes å endres i nye generasjoner av brukere. Tre av ti kvinner i aktuell alder bruker systemiskbehandling med slike midler i dag. Det kan se ut til at sosioøkonomiske faktorers betydning for bruk minsker,mens behandlingslengden øker.Bakken K, Eggen AE. Systemisk behandling gir 27,3% nåværende brukere, mens hele 38,0% har brukt slik midler noengang. Gjennomsnittlig brukstid varierer fra ca. 2 år hos tidligere brukere til ca. 4,5 år hos de som bruker nå.Brukere ser ut til å være slankere og ha høyere husholdsinntekt enn ikke-brukere, i tillegg til at de oftere har bruktp-piller og røkt. Blant de eldste kvinnene er brukere også karakterisert ved høyere utdannelsesnivå.”Kvinner og kreft” er en prospektiv populasjonsstudie basert på utsendte spørreskjema til ettilfeldig utvalg av norske kvinner mellom 30-70 år. Undersøkelsen har pågått siden 1992, og mer enn 100 000kvinner har bidratt med svar. Artikkelen er basert på data fra et utvalg på 18 199 kvinner i alderen 45-64 år sombesvarte spørreskjema utsendt i 1996-97. Svarprosenten var 60%.Salgstall for østrogenholdige preparater knyttet til overgangsalderen er firedoblet i løpet av de siste 10år. Østrogens rolle i forebyggende behandling av kroniske sykdommer i alderdommen, for eksempel hjertekarsykdomog osteoporose, fokuseres stadig mer. Artikkelen presenterer prevalenstall for bruk, brukerkarakteristikaog varighet av behandlingen.