Inhibition of thrombin generation by the zymogen factor VII: implications for the treatment of hemophilia A by factor VIIa

NARCIS (Netherlands)

van 't Veer, C.; Golden, N. J.; Mann, K. G.

2000-01-01

Factor VII circulates as a single chain inactive zymogen (10 nmol/L) and a trace ( approximately 10-100 pmol/L) circulates as the 2-chain form, factor VIIa. Factor VII and factor VIIa were studied in a coagulation model using plasma concentrations of purified coagulation factors with reactions

Euroopa firmad on asunud oma äri ümber korraldama / Ralph Atkins, Peggy Hollinger

Index Scriptorium Estoniae

Atkins, Ralph

2004-01-01

Euroopa Liidu juhtide sõnul liigutakse aeglaselt 2000. aastal Lissaboni tippkohtumisel seatud sihtidele viia Euroopa majandus konkurentsivõimelt esikohale maailmas. Euroopa ettevõtted on asunud äri ümberstruktureerima eesmärgiga kärpida kulusid ja leida firmade konkurentsieeliseid. Lisad: Muundumine nagu õpikus; Ümberkorraldamise tulemused siiani teadmata; Erik Aru. Eestis on eduka restruktureerimise näiteks Baltika ja Harju Elekter

When tough decisions must be made / Eriks Jekabsons ; interv. Aaron Eglitis

Index Scriptorium Estoniae

Jekabsons, Eriks

2005-01-01

Läti siseminister Eriks Jekabsons skandaalist seoses lisarahade maksmisega kõrgematele politseinikele, politseinike töölt lahkumisest ning Boriss Berezovski ja Alexander Kazakovi riigist väljasaatmisest

The regulation of the factor VII-dependent coagulation pathway: rationale for the effectiveness of recombinant factor VIIa in refractory bleeding disorders

NARCIS (Netherlands)

van't Veer, C.; Mann, K. G.

2000-01-01

We have explored the molecular basis of the clinical therapeutic effect of factor VIIa in hemophilia A using empirical reconstituted in vitro thrombin generation models. Tissue factor acts as a receptor and activator of preexistent but virtually inactive two-chain plasma factor VIIa. However, most

Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells.

Science.gov (United States)

el-Amraoui, A; Sahly, I; Picaud, S; Sahel, J; Abitbol, M; Petit, C

1996-08-01

Usher syndrome type 1 (USH1) associates severe congenital deafness, vestibular dysfunction and progressive retinitis pigmentosa leading to blindness. The gene encoding myosin VIIA is responsible for USH1B. Mutations in the murine orthologous gene lead to the shaker-1 phenotype, which manifests cochlear and vestibular dysfunction, without any retinal defect. To address this phenotypic discrepancy, the expression of myosin VIIA in retinal cells was analyzed in human and mouse during embryonic development and adult life. In the human embryo, myosin VIIA was present first in the pigment epithelium cells, and later in these cells as well as in the photoreceptor cells. In the adult human retina, myosin VIIA was present in both cell types. In contrast, in mouse, only pigment epithelium cells expressed the protein throughout development and adult life. Myosin VIIA was also found to be absent in the photoreceptor cells of other rodents (rat and guinea-pig), whereas these cells expressed the protein in amphibians, avians and primates. These observations suggest that retinitis pigmentosa of USH1B results from a primary rod and cone defect. The USH1B/shaker-1 paradigm illustrates a species-specific cell pattern of gene expression as a possible cause for the discrepancy between phenotypes involving defective orthologous genes in man and mouse. Interestingly, in the photoreceptor cells, myosin VIIA is mainly localized in the inner and base of outer segments as well as in the synaptic ending region where it is co-localized with the synaptic vesicles. Therefore, we suggest that myosin VIIA might play a role in the trafficking of ribbon-synaptic vesicle complexes and the renewal processes of the outer photoreceptor disks.

Monocytes can be induced by lipopolysaccharide-triggered T lymphocytes to express functional factor VII/VIIa protease activity

OpenAIRE

1984-01-01

In the present study we demonstrate that human monocytes can be induced by the model stimulus, lipopolysaccharide (LPS), to produce and assemble on their surface functional Factor VII/VIIa. This protease was not induced in relatively purified monocytes alone following exposure to LPS; but was induced in the presence of Leu-3a positive helper/inducer T cells. The Factor VII/VIIa protease activity represented 35-40% of the potential initiating activity for the extrinsic coagulation pathway and ...

Jazzikuu trummari joonistas 8-aastane Erik Jelle

Index Scriptorium Estoniae

2009-01-01

Jazzikuu 2009 kooliõpilaste plakatikonkursist, žürii koosseis. Konkursi tulemused: 1. koht - Erik Jelle, 2. koht - Liis Hiie (Sally Stuudio Kunstikool), 3.-4. koht - Ave Auser (Tartu Kunstigümnaasium), Anett Seliin Hunt (Tallinna 21. keskkool). Sally Stuudio eripreemia - Liis Pajanen (Tallinna Pääsküla Gümnaasium). Parim töö kaunistab Jazzikuu meeneid. Näitus konkursi töödest on avatud Kristiine keskuse 2. korrusel

Human recombinant factor VIIa may improve heat intolerance in mice by attenuating hypothalamic neuronal apoptosis and damage.

Science.gov (United States)

Hsu, Chuan-Chih; Chen, Sheng-Hsien; Lin, Cheng-Hsien; Yung, Ming-Chi

2014-10-01

Intolerance to heat exposure is believed to be associated with hypothalamo-pituitary-adrenocortical (HPA) axis impairment [reflected by decreases in blood concentrations of both adrenocorticotrophic-hormone (ACTH) and corticosterone]. The purpose of this study was to determine the effect of human recombinant factor VIIa (rfVIIa) on heat intolerance, HPA axis impairment, and hypothalamic inflammation, ischemic and oxidative damage, and apoptosis in mice under heat stress. Immediately after heat stress (41.2 °C for 1 h), mice were treated with vehicle (1 mL/kg of body weight) or rfVIIa (65-270 µg/kg of body weight) and then returned to room temperature (26 °C). Mice still alive on day 4 of heat exposure were considered survivors. Cellular ischemia markers (e.g., glutamate, lactate-to-pyruvate ratio), oxidative damage markers (e.g., nitric oxide metabolite, hydroxyl radials), and pro-inflammatory cytokines (e.g., interleukin-6, interleukin-1β, tumor necrosis factor-α) in hypothalamus were determined. In addition, blood concentrations of both ACTH and corticosterone were measured. Hypothalamic cell damage was assessed by determing the neuronal damage scores, whereas the hypothalamic cell apoptosis was determined by assessing the numbers of cells stained with terminal deoxynucleotidyl transferase-mediated αUTP nick-end labeling, caspase-3-positive cells, and platelet endothelial cell adhesion molecula-1-positive cells in hypothalamus. Compared with vehicle-treated heated mice, rfVIIa-treated heated mice had significantly higher fractional survival (8/10 vs 1/10), lesser thermoregulatory deficit (34.1 vs 24.8 °C), lesser extents of ischemic, oxidative, and inflammatory markers in hypothalamus, lesser neuronal damage scores and apoptosis in hypothalamus, and lesser HPA axis impairment. Human recombinant factor VIIa appears to exert a protective effect against heatstroke by attenuating hypothalamic cell apoptosis (due to ischemic, inflammatory, and oxidative damage

Grindeks saab Tallinna Farmaatsiatehase börsilt ära viia / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2005-01-01

Tallinna Farmaatsiatehase ostnud Läti Grindeks on kätte saanud vajalikud 95% aktsiatest, mis võimaldavad firma börsilt ära viia. Diagramm: Grindeksi käive ja aktsia. Vt. samas: Lauri Matsulevitsh. Investor teenis Grindeksiga 40 000 krooni

Technical progress report on Wendelstein VII-AS

International Nuclear Information System (INIS)

Sapper, J.

1985-01-01

The modification of the WENDELSTEIN experiment at Garching into an advanced version with modular design was approved in 1982, after a planning time of one and a half year. The essential components /1,2/ of the new WENDELSTEIN VII-AS device are: - A modular field system instead of a helix and TF-system, consisting of 45 nonplanar coils. - A modular vacuum vessel, adapted to the coil system. - An additional TF-system for t-variation, consisting of 10 plane coils. - A structure shell for the modular field coils so that the vessel is free of coil forces

Pärnumaal koolitati välisernalasi / Erik Reinhold ; interv. Ivar Jõesaar

Index Scriptorium Estoniae

Reinhold, Erik

2004-01-01

Kaitseliidu Pärnumaa maleva pealik kapten Erik Reinhold räägib Pärnumaal toimunud patrullvõistluse Erna retk 2004 ettevalmistuslaagrist, milles Eesti, Saksamaa ja Türgi võistkonnad läbisid väljaõppeprogrammi

Medelklassens buspojkar: en maskulinitetsstudie i Erik Pallins Pojkarna på Klasro

Directory of Open Access Journals (Sweden)

Öhrn, Magnus

2011-03-01

Full Text Available In my article, “Young rascals of the middle-class–masculinities in Erik Pallins Pojkarna på Klasro”, I argue that Pojkarna på Klasro (1922 in many regards is a typical boy's book, and a good starting-point for mapping out and studying the Swedish branch of the genre, a genre defined by gender. During the 1920s the Swedish author Erik Pallin (1878–1964 wrote five books about the three brothers Erik, Nisse and Anders, which all take place at the family's summerhouse Klasro during school holidays. The stories mainly revolve around typical boyhood adventures and outdoor activities, such as hiking, exploring, swimming, rowing, and fighting other gangs of boys, in this case, preferably boys of the lower classes. Not surprisingly, Pallin's text describes a patriarchal hierarchy, where the boys are adjusted to hegemonic masculinity and driven by homosocial desire, which leads to the excluding of girls; most female characters play subordinated (anonymous parts and are bound up with the domestic sphere. In terms of power, an intersectional perspective shows that besides gender, age, physical abilities, geographical domicile (in this case Stockholm and class are important factors when the boys establish their pecking order. An interesting aspect of the fact that the boys belong to the middle-class, is the lack of typical boy's discourse (slang, puns, oaths etc., which otherwise is common in Swedish boy's books of this era.

Magnetic surfaces and localized perturbations in the Wendelstein VII-A stellarator

International Nuclear Information System (INIS)

Wobig, H.

1986-09-01

The critical dependence of plasma confinement in low-shear stellarators, such as Wendelstein VII-A, on the external rotational transform can be explained on the basis of magnetic surface destruction. External symmetry-breaking perturbations generate islands on the low order rational magnetic surfaces. The islands are largest at t=1/2 and t=1/3. Confinement is optimum in close proximity to these values. In order to study the structure of surfaces under the influence of perturbations, a mapping procedure is used instead of field line integration. It is found that the neighbourhood of low- order rational surfaces is particularly robust against surface destruction. The reason is that in this vicinity only rational surfaces with large m and n exist (t=m/n). On these surfaces the external perturbation only generates small islands. In W VII-A the current leads to the helical windings are one symmetry- breaking perturbation, and there might also be others. It is possible to avoid field errors of this kind in future stellarators. (orig.)

Fremantle Media ekspordib seriaale kogu maailma / Andrew Edgecliffe-Johnson ; tõlk. Erik Aru

Index Scriptorium Estoniae

Edgecliffe-Johnson, Andrew

2007-01-01

Teleproduktsioonifirmast Fremantle Media. Saateformaatide eksportimisel saavutatud edu teeb firmast õpikunäite, kuidas viia tooteid üle maailma, muutes neid just piisavalt, et sobida kohaliku maitsega, jäädes samas truuks algideele. Edu ei vaja tõlget

Tallinn nimetas Poska stipendiumi saajad

Index Scriptorium Estoniae

2006-01-01

Tallinna linnavalitsus nimetas 10. mai istungil Jaan Poska stipendiumi saajad. Stipendium määrati kümnele Tallinna Tehnikaülikooli üliõpilasele : Eve Eenmaa, Andrus Räämet, Jelena Hartšenko, Andres Viia, Maksim Jenihhin, Raul Naadel, Martins Sarkans, Dmitri Šumigin, Külliki Tafel, Minna Varikmaa. Jaan Poska stipendium määratakse üliõpilasele silmapaistva ühiskondliku tegevuse eest Eesti ja Tallinna arengu heaks

Erik Rasmussen, Niels Bohr og Værdirelativismen - i anledning af Kasper Lippert-Rasmussens bog om Erik Rasmussen

DEFF Research Database (Denmark)

Ougaard, Morten

2015-01-01

En svaghed ved Kasper Lippert-Rasmussens i øvrigt udmærkede bog om Erik Rasmussen er, at den forbigår den sene Rasmussens bog om komplementaritet og statskundskab. Bogen var vigtig for Rasmussen, og den bør indgå i hans faglige eftermæle. Den rummer videnskabsteoretiske argumenter af stor relevans...... ikke mindst forholdet mellem normative og kognitive udsagn. Efter mødet med Niels Bohrs filosofi står Rasmussens værdirelativisme både skarpere og stærkere end før, og Kasper Lippert-Rasmussens karakteristik af denne position som et ubegrundet dogme i dansk politologi er ikke overbevisende....

Investigation of current drive possibilities with the present ICRH system in Wendelstein VII-AS

International Nuclear Information System (INIS)

Chiu, S.C.

1990-01-01

With the double antenna configuration, designed for first heating tests on W VII-AS, a maximum driven current of 390 A/MW coupled can be expected when using a frequency of 75 MHz and a phasing of π/2. (orig.)

Mägede vaikuses ja lumeväljade lummuses / Kristjan Erik Suurväli

Index Scriptorium Estoniae

Suurväli, Kristjan Erik

2003-01-01

MTÜ Freerider esindajatel Peeter Luigel ja Kristjan Erik Suurväljal avanes võimalus Russian Heliboarding Club kutsel käia tutvumas heliski võimalustega Kaukaasia, Usbekistani ja Kõrgõstani mägedes

Large enhancement of functional activity of active site-inhibited factor VIIa due to protein dimerization: insights into mechanism of assembly/disassembly from tissue factor.

Science.gov (United States)

Stone, Matthew D; Harvey, Stephen B; Martinez, Michael B; Bach, Ronald R; Nelsestuen, Gary L

2005-04-26

Active site-inhibited blood clotting factor VIIa (fVIIai) binds to tissue factor (TF), a cell surface receptor that is exposed upon injury and initiates the blood clotting cascade. FVIIai blocks binding of the corresponding enzyme (fVIIa) or zymogen (fVII) forms of factor VII and inhibits coagulation. Although several studies have suggested that fVIIai may have superior anticoagulation effects in vivo, a challenge for use of fVIIai is cost of production. This study reports the properties of dimeric forms of fVIIai that are cross-linked through their active sites. Dimeric wild-type fVIIai was at least 75-fold more effective than monomeric fVIIai in blocking fVIIa association with TF. The dimer of a mutant fVIIai with higher membrane affinity was 1600-fold more effective. Anticoagulation by any form of fVIIai differed substantially from agents such as heparin and showed a delayed mode of action. Coagulation proceeded normally for the first minutes, and inhibition increased as equilibrium binding was established. It is suggested that association of fVIIa(i) with TF in a collision-dependent reaction gives equal access of inhibitor and enzyme to TF. Assembly was not influenced by the higher affinity and slower dissociation of the dimer. As a result, anticoagulation was delayed until the reaction reached equilibrium. Properties of different dissociation experiments suggested that dissociation of fVIIai from TF occurred by a two-step mechanism. The first step was separation of TF-fVIIa(i) while both proteins remained bound to the membrane, and the second step was dissociation of the fVIIa(i) from the membrane. These results suggest novel actions of fVIIai that distinguish it from most of the anticoagulants that block later steps of the coagulation cascade.

Efficacy of recombinant factor VIIa administered by continuous infusion to haemophilia patients with inhibitors

NARCIS (Netherlands)

Mauser-Bunschoten, EP; Koopman, MMW; Goede-Bolder, ADE; Leebeek, FWG; Van der Meer, J; Kooij, GMV; Van der Linden, PWG

We have prospectively monitored treatment of haemophilia patients with inhibitors by recombinant factor VIIa (rFVIIa) administered by continuous infusion to obtain more insight in the underlying factors of the clinical efficacy of this administration method. At present, 43 treatment episodes of 14

Influence of cardiopulmonary bypass on the interaction of recombinant factor VIIa with activated platelets

DEFF Research Database (Denmark)

Kjalke, M.; Runge, M.; Rojkjaer, R.

2009-01-01

Recombinant factor VIIa (rFVIIa) interacts preferentially with coated platelets characterized by a high exposure of phosphatidyl serine (PS), FV, FVIII, FIX, and FX binding, and fibrinogen. Cardiopulmonary bypass (CPB) is known to impair platelet function. In this study, the influence of CPB...

Recombinant factor VIIa treatment for asymptomatic factor VII deficient patients going through major surgery.

Science.gov (United States)

Livnat, Tami; Shenkman, Boris; Spectre, Galia; Tamarin, Ilia; Dardik, Rima; Israeli, Amnon; Rivkind, Avraham; Shabtai, Moshe; Marinowitz, Uri; Salomon, Ophira

2012-07-01

Factor VII deficiency is the most common among the rare autosomal recessive coagulation disorders worldwide. In factor VII deficient patients, the severity and clinical manifestations cannot be reliably determined by factor VII levels. Severe bleeding tends to occur in individuals with factor VII activity levels of 2% or less of normal. Patients with 2-10% factor VII vary between asymptomatic to severe life threatening haemorrhages behaviour. Recombinant factor VIIa (rFVIIa) is the most common replacement therapy for congenital factor VII deficiency. However, unlike haemophilia patients for whom treatment protocols are straight forward, in asymptomatic factor VII deficiency patients it is still debatable. In this study, we demonstrate that a single and very low dose of recombinant factor VIIa enabled asymptomatic patients with factor VII deficiency to go through major surgery safely. This suggestion was also supported by thrombin generation, as well as by thromboelastometry.

Neutron flux measurements at the Wendelstein VII-A stellarator

International Nuclear Information System (INIS)

Weller, A.; Maassberg, H.

1985-10-01

In addition to charge exchange analysis (CX) and charge exchange recombination spectroscopy (CXRS), the time evolution of the central ion temperature during neutral beam heated plasma discharges in the Wendelstein VII-A stellarator is derived from the neutron flux from thermal D-D reactions. In general, good quantitative agreement between the different methods is obtained. Neutron flux measurements also permit to investigate the slowing down of fast D + -ions from neutral beam injection (NBI). The results agree well with the predictions based on the assumption of a collisional slowing down mechanism. (orig.)

Current driven drift instability in the W VII-A stellarator

International Nuclear Information System (INIS)

Deutsch, R.; Wobig, H.

1978-12-01

The instability region and growth rates of current driven drift modes in the W VII-A stellarator are calculated. Several theoretical results are evaluated for specific temperature and density profiles. It is found that in the outer region of the plasma-column (r > 6 cm) collisional drift waves with wavelengths (k 2 x + K 2 y)sup(-1/2) = 0.13 - 0.3 cm exist. In this region also the electron thermal conductivity determined experimentally appears to be large. (orig./GG) [de

Analüütikud soovitavad Eesti Energia börsile viia / Piret Reiljan

Index Scriptorium Estoniae

Reiljan, Piret, 1983-

2008-01-01

Kohalikud analüütikud soovitavad viia Eesti Energia börsile, kuna see elavdaks aktsiaturgu ja tõmbaks ligi välisinvestoreid. Vt. samas: Raivo Vare: raske aeg töötab Eesti Energia börsiletoomise kasuks; Analüüs ootab pääsu valitsuskabinetti; Juhid ei püsi enam Eesti Energias. Diagrammid: Majandusnäitajad; Varade maht

Miks Ida-Euroopa reformidest väsis / Stefan Wagstyl, Christopher Condon ; tõlk. Erik Aru

Index Scriptorium Estoniae

Wagstyl, Stefan

2006-01-01

Ungari, Tšehhi, Poola, Slovakkia sisepoliitilisest olukorrast. Autorite sõnul on kõikjal piirkonnas langenud eurotsooniga liitumise kavad poliitika ohvriks; majandusteadlaste väitel jätab Kesk-Euroopa kasutamata võimaluse läbi viia uuendusi, mida peab hiljem niikuinii tegema

Viking Line'i lahkuva "kapteni" 9 põhimõtet / Nils-Erik Eklund

Index Scriptorium Estoniae

Eklund, Nils-Erik

2009-01-01

2009. aasta 1. juunil 50-aastaseks saanud laevakompanii Viking Line ametist lahkuv juht Nils-Erik Eklund vastab küsimustele, mis puudutavad oma isa, Viking Line'i asutaja Gunnar Eklundi jälgedes käimist, ettevõtte võimalikku laienemist teistesse tegevusaladesse, peamisi juhtimispõhimõtteid ning keerulisemaid hetki Viking Line'i ajaloos

Factor VIIa binding and internalization in hepatocytes

DEFF Research Database (Denmark)

Hjortoe, G; Sorensen, B B; Petersen, L C

2005-01-01

The liver is believed to be the primary clearance organ for coagulation proteases, including factor VIIa (FVIIa). However, at present, clearance mechanisms for FVIIa in liver are unknown. To obtain information on the FVIIa clearance mechanism, we investigated the binding and internalization...... no effect. HEPG2 cells internalized FVIIa with a rate of 10 fmol 10(-5) cells h(-1). In contrast to HEPG2 cells, FVIIa binding to primary rat hepatocytes was completely independent of TF, and excess unlabeled FVIIa partly reduced the binding of 125I-FVIIa to rat hepatocytes. Further, compared with HEPG2...... cells, three- to fourfold more FVIIa bound to rat primary hepatocytes, and the bound FVIIa was internalized at a faster rate. Similar FVIIa binding and internalization profiles were observed in primary human hepatocytes. Plasma inhibitors had no effect on FVIIa binding and internalization in hepatocytes...

Effect of tearing modes on temperature and density profiles and on the perpendicular transport in the W VII-A stellarator

International Nuclear Information System (INIS)

Jaenicke, R.

1988-01-01

In the ohmically heated W VII-A stellarator, the behaviour of which is similar to that of a medium sized tokamak, the additional shearless external rotational transform t 0 (Δt 0 /t 0 0 perpendicular,e in a one-dimensional heat transport code. In this way, the measured temperature profiles can be reproduced quite well and the energy confinement time of discharges with tearing mode activity can be predicted quantitatively. The transport model is used to investigate the explicit dependence of κ perpendicular,e on the plasma current and to study the importance of plasma current driven instabilities for the energy confinement in the W VII-A stellarator as well as in tokamaks. (author). 19 refs, 14 figs

The Effect of Recombinant Factor VIIa and Fibrinogen on Bleeding from Grade V Liver Injuries in Coagulopathic Swine

National Research Council Canada - National Science Library

Brundage, Susan

2003-01-01

This was a 2 part study. The first part of the study was performed to determine if recombinant factor VIIa would reduce bleeding after a grade V liver injury in hypothermic, dilutionally coagulopathic pigs when used...

Neutral gas transport and particle recycling in the W VII-AS stellarator

International Nuclear Information System (INIS)

Sardei, F.; Ringler, H.; Dodhy, A.; Kuehner, G.

1990-01-01

Neutral gas transport simulations with the 3D DEGAS code were applied to model plasmas before the W VII-AS operation was started. For a source of neutrals due to limiter recycling the calculated neutral density distribution is strongly affected by the asymmetries of the magnetic flux surfaces, limiter and wall structures. For a typical ECF heated deuterium discharge from the first months of W VII-AS operation the time histories of H α signals at five toroidal positions provide information about the neutral fluxes due to limiter and wall recycling and to gas puffing. The H α signals are used to scale the calculated 3D distributions of the neutrals and the radial profiles of the ion sources as obtained from the DEGAS code. By comparing the results for the three different neutral sources the limiter is found to provide more than 80% of the plasma refuelling, with a recycling coefficient of about 95%. The calculated total particle fluxes resulting from the integrated ion sources are consistent with neoclassical predictions in the temperature gradient region. Near the plasma edge, however, the fluxes are strongly anomalous. The diffusion coefficient estimated from the fluxes and the measured density gradients (with z eff approx. 3) is about 1/10 - 1/20 of the electron heat conductivity. (author). 6 refs, 10 figs

[Hemoglobins, XXXII. Analysis of the primary structure of the monomeric hemoglobin CTT VIIA (erythrocruorin) or Chironomus thummi thummi, Diptera (author's transl)].

Science.gov (United States)

Kleinschmidt, T; Braunitzer, G

1980-01-01

The dimeric hemoglobin CTT VIIA (erythrocruorin) was isolated from the hemolymph of the larva from Chironomus thummi thummi and purified by preparative polyacrylamide gel electrophoresis. Peptides obtained by limited tryptical digestion were sequenced by automatic Edman degradation. For the elucidation of the sequence in the C-terminal region of the chain, additional cleavages with proteinase of Staphylococcus aureus and chymotrypsin were necessary. CTT VIIA is compared with human beta-chains and other hemoglobins of Chironomus. The amino acid residues in the pocket are especially discussed. Most of them are invariant in all Chironomus hemoglobins, independent of the size of the heme pocket, which is normal in some components and enlarged in others.

Tiede ja tutkijan sosiaalinen vastuu : Joseph Ben-Davidin, Roger Sperryn ja Knut Erik Tranøyn käsitykset tieteestä ja tutkijan sosiaalisesta vastuusta

OpenAIRE

Karppela, Lasse

2006-01-01

Science and the Scientist's Social Responsibility. Joseph Ben-David's, Roger Sperry's and Knut Erik Tranøy's Views of Science and the Scientist's Social Responsibility The aim of the study was to investigate, whether or not there is any connection between Jewish sociologist Joseph Ben-David's, American neuroscientist Roger Sperry's and Norwegian philosopher Knut Erik Tranøy's views of science and views of the scientist's social responsibility. The sources of information were their writin...

Diveciga seotud nõuetest on miljoneid laekumata jäänud / Erik Müürsepp

Index Scriptorium Estoniae

Müürsepp, Erik

2008-01-01

Konsultatsioonifirma Divec järglasel Brolex Grupp AS-il ja Divec EAT järglasel Dreiv Grupp OÜ-l praegu maksukohustusi pole. Diveciga seotud nõuetest on lisaks juurde määratud 250 kroonist laekunud 110 miljonit. Diveci endise juhi Erik Vallaste ja Priiten Tamme maksuvõlast. Lisa: Varjamise uurimine lõpetati

Erik Gunnar Asplund’s Stockholm Public Library

DEFF Research Database (Denmark)

Andersen, Michael Asgaard

2017-01-01

Stockholm Public Library, which opened on March 31, 1928, was in many ways an innovation in the Nordic countries. Most striking was the fact that lenders could now take books off the shelves themselves, but the central placement of the lending room and the secondary placement of the reading rooms...... also indicated a new way to do libraries. The thoughts embodied in the building became a model for many later libraries. The building is not only testimony to an important period of Nordic architectural history and a recognized masterpiece by the Swedish architect Erik Gunnar Asplund (1885......–1940), it is also part of the history of the Nordic social model that was taking shape in the interwar years. By its function as a public institution and its unique architectural qualities, Stockholm Public Library today stands as an important work of Nordic welfare building....

Comparison of the calculated neutral beam shinethrough of the Wendelstein VII-A injection with calorimetric measurements

International Nuclear Information System (INIS)

Penningsfeld, F.P.

1987-06-01

Density profiles of the Wendelstein VII-A plasma as measured by Thomson scattering are used to calculate the temporally and spatially varying power density of the neutral beam shinethrough on the torus calorimeter for several shot series. The total energy deposited by the three beam species is obtained by integrating the transmitted power density in space and time. This global quantity is compared with the calorimetric measurements routinely performed for each shot. The agreement between calculated and measured energy is found to be ΔE/E = 2.3 ± 11% confirming the error estimation for the NEUDEN program used, which was only slightly modified to calculate the power density transmitted in the target plane. From this good agreement it is concluded that the program contains a realistic beam model and reliable cross-sections for the beam attenuation which is important for further applications. Furthermore, the same comparison was done with old results of the ODIN code by analyzing the corresponding raw data as far as they could be recovered, obtaining a similarly good consistency. A possible increase of 10 to 20% of the beam stopping cross section which could be expected for Wendelstein VII-A conditions by the effect of multistep collision processes as suggested by Boley et al. is discussed also. (orig.)

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry

DEFF Research Database (Denmark)

Rand, Kasper D; Andersen, Mette D; Olsen, Ole H

2008-01-01

Factor VIIa (FVIIa) circulates in the blood in a zymogen-like state. Only upon association with membrane-bound tissue factor (TF) at the site of vascular injury does FVIIa become active and able to initiate blood coagulation. Here we used hydrogen exchange monitored by mass spectrometry to invest......Factor VIIa (FVIIa) circulates in the blood in a zymogen-like state. Only upon association with membrane-bound tissue factor (TF) at the site of vascular injury does FVIIa become active and able to initiate blood coagulation. Here we used hydrogen exchange monitored by mass spectrometry...... to investigate the conformational effects of site-directed mutagenesis at key positions in FVIIa and the origins of enhanced intrinsic activity of FVIIa analogs. The differences in hydrogen exchange of two highly active variants, FVIIa(DVQ) and FVIIa(VEAY), imply that enhanced catalytic efficiency was attained...

Hemophilia B with mutations at glycine-48 of factor IX exhibited delayed activation by the factor VIIa-tissue factor complex.

Science.gov (United States)

Wu, P C; Hamaguchi, N; Yu, Y S; Shen, M C; Lin, S W

2000-10-01

Gly-48 is in the conserved DGDQC sequence (residues 47-51 of human factor IX) of the first EGF (EGF-1)-like domain of factor IX. The importance of the Gly-48 is manifested by two hemophilia B patients; factor IXTainan and factor IXMalmo27, with Gly-48 replaced by arginine (designated IXG48R) and valine (IXG48V), respectively. Both patients were CRM+ exhibiting mild hemophilic episodes with 25% (former) and 19% (latter) normal clotting activities. We characterize both factor IX variants to show the roles of Gly-48 and the conservation of the DGDQC sequence in factor IX. Purified plasma and recombinant factor IX variants exhibited approximately 26%-27% normal factor IX's clotting activities with G48R or G48V mutation. Both variants depicted normal quenching of the intrinsic fluorescence by increasing concentrations of calcium ions and Tb3+, indicating that arginine and valine substitution for Gly-48 did not perturb the calcium site in the EGF-1 domain. Activation of both mutants by factor XIa appeared normal. The reduced clotting activity of factors IXG48R and IXG48V was attributed to the failure of both mutants to cleavage factor X: in the presence of only phospholipids and calcium ions, both mutants showed a 4 to approximately 7-fold elevation in Km, and by adding factor VIIIa to the system, although factor VIIIa potentiated the activation of factor X by the mutants factor IXaG48R and factor IXaG48V, a 2 to approximately 3-fold decrease in the catalytic function was observed with the mutant factor IXa's, despite that they bound factor VIIIa on the phospholipid vesicles with only slightly reduced affinity when compared to wild-type factor IXa. The apparent Kd for factor VIIIa binding was 0.83 nM for normal factor IXa, 1.74 nM for IXaG48R and 1.4 nM for IXaG48V. Strikingly, when interaction with the factor VIIa-TF complex was examined, both mutations were barely activated by the VIIa-TF complex and they also showed abnormal interaction with VIIa-TF in bovine

Untapped richness in Erik H. Erikson's rootstock.

Science.gov (United States)

Kivnick, Helen Q; Wells, Courtney K

2014-02-01

Erik H. Erikson published his groundbreaking theory of 8 stages of lifelong psychosocial development in 1950. His theory expanded psychoanalytic concepts of psychosexual development to include the importance of social dynamics; it transcended then-current thinking that psychological development culminated in early adulthood, acknowledging that systematic human development continues throughout the entire life cycle. The theory made Erikson a pioneer in developmental psychology. His last authored book, Vital Involvement in Old Age, rearticulated and elaborated 3 principles that, in different words, are rooted in his original theory of healthy life cycle development: (1) Dynamic Balance of Opposites; (2) Vital Involvement; and (3) Life in Time. Using a lens informed by knowledge gained over the past 30 years and by reflections of one of the original researchers on that project, the current manuscript seeks to spark new interest in Erikson's late-life contribution. It explains the principles in new detail, links them to relevant research, and suggests ways they could enable Erikson's ideas to further enrich gerontological practice and research.

Comparison of 3-Factor Prothrombin Complex Concentrate and Low-Dose Recombinant Factor VIIa for Warfarin Reversal

OpenAIRE

Chapman, Scott A; Irwin, Eric D; Abou-Karam, Nada M; Rupnow, Nichole M; Hutson, Katherine E; Vespa, Jeffrey; Roach, Robert M

2014-01-01

Introduction Prothrombin complex concentrate (PCC) and recombinant Factor VIIa (rFVIIa) have been used for emergent reversal of warfarin anticoagulation. Few clinical studies have compared these agents in warfarin reversal. We compared warfarin reversal in patients who received either 3 factor PCC (PCC3) or low-dose rFVIIa (LDrFVIIa) for reversal of warfarin anticoagulation. Methods Data were collected from medical charts of patients who received at least one dose of PCC3 (20 units/kg) or LDr...

Thermal analysis of W VII-AS limiter system and presentation of a graphite-block concept

International Nuclear Information System (INIS)

Mukherjee, S.; Grigull, P.

1989-01-01

A 2D-finite element thermal analysis of the initial W VII-AS limiter system has been performed and is discussed. Furhter to this analysis a graphite block concept is presented. This concept has been numerically analyzed for applications as a limiter in plasma and nuclear fusion experimental devices. The results are described in this paper. This block concept seems to be also applicable to first wall and divertor designs; the graphite elements could be replaced by ceramic ones. (author). 10 refs.; 13 figs

Mutation profile of all 49 exons of the human myosin VIIA gene, and haplotype analysis, in Usher 1B families from diverse origins.

Science.gov (United States)

Adato, A; Weil, D; Kalinski, H; Pel-Or, Y; Ayadi, H; Petit, C; Korostishevsky, M; Bonne-Tamir, B

1997-10-01

Usher syndrome types I (USH1A-USH1E) are a group of autosomal recessive diseases characterized by profound congenital hearing loss, vestibular areflexia, and progressive visual loss due to retinitis pigmentosa. The human myosin VIIA gene, located on 11q14, has been shown to be responsible for Usher syndrome type 1B (USH1B). Haplotypes were constructed in 28 USH1 families by use of the following polymorphic markers spanning the USH1B locus: D11S787, D11S527, D11S1789, D11S906, D11S4186, and OMP. Affected individuals and members of their families from 12 different ethnic origins were screened for the presence of mutations in all 49 exons of the myosin VIIA gene. In 15 families myosin VIIA mutations were detected, verifying their classification as USH1B. All these mutations are novel, including three missense mutations, one premature stop codon, two splicing mutations, one frameshift, and one deletion of >2 kb comprising exons 47 and 48, a part of exon 49, and the introns between them. Three mutations were shared by more than one family, consistent with haplotype similarities. Altogether, 16 USH1B haplotypes were observed in the 15 families; most haplotypes were population specific. Several exonic and intronic polymorphisms were also detected. None of the 20 known USH1B mutations reported so far in other world populations were identified in our families.

Comment on 'The origin of neap-spring tidal cycles' by Erik P. Kvale [Marine Geology 235 5-18

NARCIS (Netherlands)

Hoitink, A.J.F.

2008-01-01

This paper comments on a recent publication by Erik P. Kvale [Marine Geology 235 (2006) 5–18], who underlines the importance of tropically driven neap–spring cycles. Here it is stressed that tropically driven neap–spring cycles feature a systematic asymmetry, prevalent in both flow velocity time

Den orättvisaste orättvisan. Heroism och alternativ maskulinitet i Hans Erik Engqvists ungdomsroman Tredagarskriget

Directory of Open Access Journals (Sweden)

Olle Widhe

2014-06-01

Full Text Available ”Wicked Wrongfulness. Heroism and Alternative Versions of Masculinity in Hans Erik Engqvist’s Young Adult Novel Three Days War”. This article examines the re-evaluation of modern masculinity in the YA novel Three Days War by the Swedish author Hans Erik Engqvist (b. 1934. The central argument is that the fictional representation of Children Playing War in the novel is intertwined with the imagining of competing masculinities as well as opposing ideologies in post-war Sweden. Thus, the expression of institutionalized middle-class masculinity is contrasted to the representation of an alternative left wing working-class masculinity in opposition to social hierarchy and social inequality. Through different allusions to heroic men and heroic behaviour in 19th century literature and American Western films the novel invites the reader to evoke hegemonic masculinity as a schema shaping both the understanding of the young characters and their play. But the novel also interrogates this institutionalized myth of hegemonic masculinity and sets the main character, as well as the reader, in search of an alternative version of the heroic male.

Den orättvisaste orättvisan. Heroism och alternativ maskulinitet i Hans Erik Engqvists ungdomsroman Tredagarskriget

Directory of Open Access Journals (Sweden)

Widhe, Olle

2015-12-01

Full Text Available ”Wicked Wrongfulness. Heroism and Alternative Versions of Masculinity in Hans Erik Engqvist’s Young Adult Novel Three Days War”. This article examines the re-evaluation of modern masculinity in the YA novel Three Days War by the Swedish author Hans Erik Engqvist (b. 1934. The central argument is that the fictional representation of Children Playing War in the novel is intertwined with the imagining of competing masculinities as well as opposing ideologies in post-war Sweden. Thus, the expression of institutionalized middle-class masculinity is contrasted to the representation of an alternative left wing working-class masculinity in opposition to social hierarchy and social inequality. Through different allusions to heroic men and heroic behaviour in 19th century literature and American Western films the novel invites the reader to evoke hegemonic masculinity as a schema shaping both the understanding of the young characters and their play. But the novel also interrogates this institutionalized myth of hegemonic masculinity and sets the main character, as well as the reader, in search of an alternative version of the heroic male.

Corrosion evaluation of heat recovery steam generator superheater tube in two methods of testing: Tafel polarization and electrochemical impedance spectroscopy (EIS)

Science.gov (United States)

Santoso, Rio Pudjidarma; Riastuti, Rini

2018-05-01

The purpose of this research is to evaluate the corrosion process which occurs on the water side of Heat Recovery Steam Generator (HRSG) superheater tube. The tube was 13CrMo44 and divided into 3 types of specimen: new tube, used tube (with oxide layer on surface), cleaned-used tube (without oxide layer on surface). The evaluation of corrosion parameters wasperformed using deaerated ultra-high purity water (boiler feed water) in two methods of testing: Tafel polarization and Electrochemical Impedance Spectroscopy (EIS). Tafel polarization was excellent as its capability to show the value of corrosion current and the corrosion rate explicitly, on the other hand, EIS was excellent as its capability to explain for corrosion mechanism on metal interface in detail. Both methods showed that the increase of electrolyte temperature from 25°C to 55°C would increase the corrosion rate with the mechanism of decreasing polarization resistance due to thinning out the passive film thickness and enlarge the area of reduction reaction of cathode. Magnetite oxide scale which is laid on the surface of used tube specimen shows protective nature to reduce the corrosion rate, and clear up this oxide would increase the corrosion rate back as new tube.

Vacuum magnetic field and modular coil system of the advanced stellarator Wendelstein VII-AS

International Nuclear Information System (INIS)

Rau, F.; Kisslinger, J.; Wobig, H.

1982-06-01

The vacuum field and the modular coils of the advanced stellarator WENDELSTEIN VII-AS are described. Each of the five field periods contains 9 different twisted coils, one of them with increased dimensions and current in order to provide sufficient access. The standard vacuum field configuration (B=3 T, t=0.39, aspect ratio approx. equal to 10, low shear, and magnetic well) can be varied by toroidal and vertical fields, or by changing independently the current in the large special coils. From a study of magnetic field perturbations some estimates are derived for the admissible coil tolerances. (orig.)

The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface

NARCIS (Netherlands)

Weeterings, Cees; de Groot, Philip G.; Adelmeijer, Jelle; Lisman, Ton

2008-01-01

Several lines of evidence suggest that recombinant factor VIIa (rFVIIa) is able to activate factor X on an activated platelet, in a tissue factor-independent manner. We hypothesized that, besides the anionic surface, a receptor on the activated platelet surface is involved in this process. Here, we

Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia

NARCIS (Netherlands)

de Pont, A. C. J. M.; Moons, A. H. M.; de Jonge, E.; Meijers, J. C. M.; Vlasuk, G. P.; Rote, W. E.; Büller, H. R.; van der Poll, T.; Levi, M. [=Marcel M.

2004-01-01

The tissue factor-factor (F)VIIa complex (TF/FVIIa) is responsible for the initiation of blood coagulation under both physiological and pathological conditions. Recombinant nematode anticoagulant protein c2 (rNAPc2) is a potent inhibitor of TF/FVIIa. mechanistically distinct from tissue factor

Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia.

Science.gov (United States)

Weil, D; Levy, G; Sahly, I; Levi-Acobas, F; Blanchard, S; El-Amraoui, A; Crozet, F; Philippe, H; Abitbol, M; Petit, C

1996-04-16

The gene encoding human myosin VIIA is responsible for Usher syndrome type III (USH1B), a disease which associates profound congenital sensorineural deafness, vestibular dysfunction, and retinitis pigmentosa. The reconstituted cDNA sequence presented here predicts a 2215 amino acid protein with a typical unconventional myosin structure. This protein is expected to dimerize into a two-headed molecule. The C terminus of its tail shares homology with the membrane-binding domain of the band 4.1 protein superfamily. The gene consists of 48 coding exons. It encodes several alternatively spliced forms. In situ hybridization analysis in human embryos demonstrates that the myosin VIIA gene is expressed in the pigment epithelium and the photoreceptor cells of the retina, thus indicating that both cell types may be involved in the USH1B retinal degenerative process. In addition, the gene is expressed in the human embryonic cochlear and vestibular neuroepithelia. We suggest that deafness and vestibular dysfunction in USH1B patients result from a defect in the morphogenesis of the inner ear sensory cell stereocilia.

Hans Hulshof, Erik Kwakernaak en Frans Wilhelm, Geschiedenis van het talenonderwijs in Nederland. Onderwijs in de moderne talen van 1500 tot heden

Directory of Open Access Journals (Sweden)

Hilda T.A. Amsing

2016-11-01

Full Text Available Hans Hulshof, Erik Kwakernaak en Frans Wilhelm, Geschiedenis van het talenonderwijs in Nederland. Onderwijs in de moderne talen van 1500 tot heden (Groningen: Passage, 2015, 468 pp., isbn 978 90 5452 315 4.

A proposed model of psychodynamic psychotherapy linked to Erik Erikson's eight stages of psychosocial development.

Science.gov (United States)

Knight, Zelda Gillian

2017-09-01

Just as Freud used stages of psychosexual development to ground his model of psychoanalysis, it is possible to do the same with Erik Erikson's stages of development with regards to a model of psychodynamic psychotherapy. This paper proposes an eight-stage model of psychodynamic psychotherapy linked to Erik Erikson's eight stages of psychosocial development. Various suggestions are offered. One such suggestion is that as each of Erikson's developmental stages is triggered by a crisis, in therapy it is triggered by the client's search. The resolution of the search often leads to the development of another search, which implies that the therapy process comprises a series of searches. This idea of a series of searches and resolutions leads to the understanding that identity is developmental and therapy is a space in which a new sense of identity may emerge. The notion of hope is linked to Erikson's stage of Basic Trust and the proposed model of therapy views hope and trust as essential for the therapy process. Two clinical vignettes are offered to illustrate these ideas. Psychotherapy can be approached as an eight-stage process and linked to Erikson's eight stages model of development. Psychotherapy may be viewed as a series of searches and thus as a developmental stage resolution process, which leads to the understanding that identity is ongoing throughout the life span. Copyright © 2017 John Wiley & Sons, Ltd.

Mother, melancholia, and humor in Erik H. Erikson's earliest writings.

Science.gov (United States)

Capps, Donald

2008-09-01

Erik H. Erikson wrote three articles when he was in his late-twenties and an up-and-coming member of the psychoanalytic community in Vienna. At the time he wrote these articles, he was in a training psychoanalysis with Anna Freud, teaching at the Heitzing School in Vienna, and learning the Montessori method of teaching. These articles focus on the loss of primary narcissism and the development of the superego (or punitive conscience) in early childhood, especially through the child's conflict with maternal authority. They support the idea that melancholia, with its internalized rage against the mother, is the inevitable outcome of the loss of primary narcissism. I note, however, that the third of these articles makes a case for the restorative role of humor, especially when Freud's view that humor is a function of the superego is taken into account.

A single-phase model for liquid-feed DMFCs with non-Tafel kinetics

Energy Technology Data Exchange (ETDEWEB)

Vera, Marcos [Area de Mecanica de Fluidos, Universidad Carlos III de Madrid, Avda. de la Universidad 30, 28911 Leganes (Spain)

2007-09-27

An isothermal single-phase 3D/1D model for liquid-feed direct methanol fuel cells (DMFC) is presented. Three-dimensional (3D) mass, momentum and species transport in the anode channels and gas diffusion layer is modeled using a commercial, finite-volume based, computational fluid dynamics (CFD) software complemented with user supplied subroutines. The 3D model is locally coupled to a one-dimensional (1D) model accounting for the electrochemical reactions in both the anode and the cathode, which provides a physically sound boundary condition for the velocity and methanol concentration fields at the anode gas diffusion layer/catalyst interface. The 1D model - comprising the membrane-electrode assembly, cathode gas diffusion layer, and cathode channel - assumes non-Tafel kinetics to describe the complex kinetics of the multi-step methanol oxidation reaction at the anode, and accounts for the mixed potential associated with methanol crossover, induced both by diffusion and electro-osmotic drag. Polarization curves computed for various methanol feed concentrations, temperatures, and methanol feed velocities show good agreement with recent experimental results. The spatial distribution of methanol in the anode channels, together with the distributions of current density, methanol crossover and fuel utilization at the anode catalyst layer, are also presented for different opperating conditions. (author)

Differentiation of hopelessness, helplessness, and powerlessness using Erik Erikson's "Roots of virtue".

Science.gov (United States)

Drew, B L

1990-10-01

Hopelessness, helplessness, and powerlessness have been identified as phenomena of concern to psychiatric nursing practice by an American Nurses' Association (ANA) task force. These concepts, however, have not been clearly distinguished from each other. The resulting lack of clarity decreases the usefulness of nursing diagnoses in directing strategies for intervention. The purpose of this article is to differentiate the phenomena of hopelessness, helplessness, and powerlessness using Erik Erikson's "Roots of virtue" as a conceptual framework. The relationship between the frustration of early childhood tasks and later adult response patterns is discussed. Clinical examples illustrate that knowledge of childhood issues guides the formulation of therapeutic goals and interventions to address the experience of hopelessness, helplessness, and powerlessness.

Synthesis of Dipeptide Benzoylalanylglycine Methyl Ester and Corrosion Inhibitor Evaluation by Tafel Equation

International Nuclear Information System (INIS)

Abdurrahman, J.; Wahyuningrum, D.; Achmad, S.; Bundjali, B.

2011-01-01

Corrosion is one of the major problems in petroleum mining and processing industry. The pipelines used to transport crude oil from reservoir to the processing installation were made from carbon steel that is susceptible towards corrosion. One of the best methods to prevent corrosion that occurred at the inner parts of carbon steel pipelines is to use organic corrosion inhibitor. One of the potent organic corrosion inhibitors is amino acids derivatives. In this study, dipeptide compound namely benzoylalanylglycine methyl ester and benzoylalanylglycine have been synthesized. The structure elucidation of the products was performed by IR, MS and NMR spectroscopy. The determination of corrosion inhibition activity utilized the Tafel method. The corrosion inhibition efficiency of glycine methyl ester, benzoyl alanine, dipeptide benzoylalanylglycine methyl ester and dipeptide benzoylalanylglycine were 63.34 %, 35.86 %, 68.40 % and 27.72 %, respectively. These results showed that the formation of dipeptide benzoylalanylglycine methyl ester, derived from carboxylic protected glycine and amine protected alanine, increased the corrosion inhibition activity due to the loss of acidity center in the structure of glycine and L-alanine that would induce the corrosive environment towards carbon steel. (author)

Identification and molecular modelling of a mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11)

NARCIS (Netherlands)

Luijendijk, M.W.J.; Wijk, E. van; Bischoff, A.M.L.C.; Krieger, E.; Huygen, P.L.M.; Pennings, R.J.E.; Brunner, H.G.; Cremers, C.W.R.J.; Cremers, F.P.M.; Kremer, J.M.J.

2004-01-01

Myosin VIIA is an unconventional myosin that has been implicated in Usher syndrome type 1B, atypical Usher syndrome, non-syndromic autosomal recessive hearing impairment (DFNB2) and autosomal dominant hearing impairment (DFNA11). Here, we present a family with non-syndromic autosomal dominant

Identification and molecular modelling of a mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11).

NARCIS (Netherlands)

Luijendijk, M.W.J.; Wijk, E. van; Bischoff, A.M.L.C.; Krieger, E.; Huygen, P.L.M.; Pennings, R.J.E.; Brunner, H.G.; Cremers, C.W.R.J.; Cremers, F.P.M.; Kremer, J.M.J.

2004-01-01

Myosin VIIA is an unconventional myosin that has been implicated in Usher syndrome type 1B, atypical Usher syndrome, non-syndromic autosomal recessive hearing impairment (DFNB2) and autosomal dominant hearing impairment (DFNA11). Here, we present a family with non-syndromic autosomal dominant

Extensive small-angle X-ray scattering studies of blood coagulation factor VIIa reveal interdomain flexibility

DEFF Research Database (Denmark)

Mosbæk, Charlotte Rode; Nolan, David; Persson, Egon

2010-01-01

Blood coagulation factor VIIa (FVIIa) is used in the treatment of replacement therapy resistant hemophilia patients, and FVIIa is normally activated upon complex formation with tissue factor (TF), potentially in context with structural rearrangements. The solution behavior of uncomplexed FVIIa...... is important for understanding the mechanism of activation and for the stability and activity of the pharmaceutical product. However, crystal structures of FVIIa in complex with TF and of truncated free FVIIa reveal different overall conformations while previous small-angle scattering studies suggest FVIIa...... causing resistance to activation, thereby emphasizing the connection between the distribution of different conformations of FVII and the mechanism of activation....

Effect of Recombinant Factor VIIa as an Adjunctive Therapy in Damage Control for Wartime Vascular Injuries: A Case Control Study

Science.gov (United States)

2009-04-01

Axillary 1 1 2 4 Iliac 2 2 4 Profunda femoral 1 3 4 Femoral 3 1 1 1 2 1 8 Popliteal 1 2 3 Total 9 1 2 4 25 6 20 2 3 72 * Followed by SV graft...VIIa [database on the Internet ]: US Department of Defense. Available at: https://jpta.fhp.osd.mil. Accessed 2007. 10. Boffard KD, Riou B, Warren B, et al

Ala397Asp mutation of myosin VIIA gene segregating in a Spanish family with type-Ib Usher syndrome.

Science.gov (United States)

Espinós, C; Millán, J M; Sánchez, F; Beneyto, M; Nájera, C

1998-06-01

In the current study, 12 Spanish families affected by type-I Usher syndrome, that was previously linked to chromosome 11q, were screened for the presence of mutations in the N-terminal coding portion of the motor domain of the myosin VIIA gene by single-strand conformation polymorphism analysis of the first 14 exons. A mutation (Ala397Asp) segregating with the disease was identified, and several polymorphisms were also detected. It is presumed that the other USHIB mutations in these families could be located in the unscreened regions of the gene.

Entfremdung als Strukturmoment von Unterricht? Eine Fallstudie zur Arbeit eines Schülers an der Tafel aus der Sicht der pädagogischen Unterrichtsforschung

OpenAIRE

Twardella, Johannes

2010-01-01

"In den 70er Jahren des 20. Jahrhunderts beobachtete Jules Henry im Rahmen seiner ethnographischen Schulforschungen die Arbeit eines Schülers an der Tafel und interpretierte sie aus einer sozialpsychologischen Perspektive heraus als einen Prozess, in dem ein Schüler lernt, was "Entfremdung" ist. Ausgehend von dieser Deutung wird in dem vorliegenden Aufsatz der Frage nachgegangen, ob der Begriff der Entfremdung auch heute noch für die Erforschung von Unterricht fruchtbar gemacht werden kann. D...

Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes

DEFF Research Database (Denmark)

Madsen, Jesper Jonasson; Persson, E.; Olsen, O. H.

2015-01-01

that are not likely to be inferred from mutagenesis studies. Furthermore, paths from Met306 to Ile153 (N-terminus) and Trp364, both representing hallmark residues of allostery, are 7% and 37% longer, respectively, in free FVIIa. Thus, there is significantly weaker coupling between the TF contact point and key......Background: Tissue factor (TF) promotes colocalization of enzyme (factorVIIa) and substrate (FX or FIX), and stabilizes the active conformation of FVIIa. Details on how TF induces structural and dynamic changes in the catalytic domain of FVIIa to enhance its efficiency remain elusive. Objective......: To elucidate the activation of allosteric networks in the catalytic domain of the FVIIa protease it is when bound to TF.MethodsLong-timescale molecular dynamics simulations of FVIIa, free and in complex with TF, were executed and analyzed by dynamic network analysis. Results: Allosteric paths of correlated...

The M358R variant of α_1-proteinase inhibitor inhibits coagulation factor VIIa

International Nuclear Information System (INIS)

Sheffield, William P.; Bhakta, Varsha

2016-01-01

The naturally occurring M358R mutation of the plasma serpin α_1-proteinase inhibitor (API) changes both its cleavable reactive centre bond to Arg–Ser and the efficacy with which it inhibits different proteases, reducing the rate of inhibition of neutrophil elastase, and enhancing that of thrombin, factor XIa, and kallikrein, by several orders of magnitude. Although another plasma serpin with an Arg–Ser reactive centre, antithrombin (AT), has been shown to inhibit factor VIIa (FVIIa), no published data are available with respect to FVIIa inhibition by API M358R. Recombinant bacterially-expressed API M358R and plasma-derived AT were therefore compared using gel-based and kinetic assays of FVIIa integrity and activity. Under pseudo-first order conditions of excess serpin over protease, both AT and API M358R formed denaturation-resistant inhibitory complexes with FVIIa in reactions accelerated by TF; AT, but not API M358R, also required heparin for maximal activity. The second order rate constant for heparin-independent API M358R-mediated FVIIa inhibition was determined to be 7.8 ± 0.8 × 10"2 M"−"1sec"−"1. We conclude that API M358R inhibits FVIIa by forming inhibitory complexes of the serpin type more rapidly than AT in the absence of heparin. The likely 20-fold excess of API M358R over AT in patient plasma during inflammation raises the possibility that it could contribute to the hemorrhagic tendencies manifested by rare individuals expressing this mutant serpin. - Highlights: • The inhibitory specificity of the serpin alpha-1-proteinase inhibitor (API) is sharply altered in the M358R variant. • API M358R forms denaturation-resistant complexes with coagulation factor VIIa at a rate accelerated by tissue factor but unaffected by heparin. • Complex formation was shown by gel-based assays and quantified kinetically by inhibition of FVIIa-dependent amidolysis.

Bilgisayar Destekli Türkçe Tabanlı Medya İçerik Çözümleme Computer Assisted Turkish Based Media Content Analysis

Directory of Open Access Journals (Sweden)

Arıkan, Aykut

2009-10-01

Full Text Available İçerik çözümleme, çözümlenen medya içeriği nesnesine, yani iletişim metnine yönelik, iyitanımlanmış sistematik bir bilgi sorgulama stratejisidir. Araştırma sürecinin ilk aşamalarındanitibaren neyin aranacağının iyi tanımlanmış olması gereklidir. İçerik çözümlemenin kuramsalaçıklamaları kimi zaman uygulamadan farklılık gösterebilir. İçerik çözümlemeye dayalıaraştırmalar ilgili çalışmanın uygun bir temelde gerçekleştirilmesi için lazım olan aşamaları,teknikleri ve süreçleri gerekli kılarken diğer yandan zaman ve işgücünden tasarrufu da gerektirir.Yeditepe Üniversitesi bünyesinde görev yapan bir grup araştırmacı, Türkçe medya içeriği içinbilgisayar destekli bir içerik çözümleme sistemi geliştirme kararına varmışlardır. Geliştirilenproje önerisi, Mayıs 2007’de TÜBİTAK’a 1001 kodlu bilimsel araştırma projesi olarak sunulmuşve 107K209 kodu ile proje olarak destekleme kararı verilmiştir. Projenin amacı, CumhuriyetDönemi Türk Basınının içeriğini çözümleyecek, Türkçe tabanlı bir içerik çözümleme sisteminigeliştirmektir. Bu projeyle geliştirilen Türkçe tabanlı bilgisayar destekli içerik çözümlemesistemiyle, Cumhuriyet Döneminde 1928’den bu yana yeni Türkçe harflerle yayımlanmış olanTürk gazetelerinin içeriklerinin çözümlenmesi için aşılması gereken en önemli altyapı engeliolan Türkçe içeriği çözümleyebilecek bilgisayar destekli sistem ihtiyacı karşılanmıştır. Bu sonuçraporunun amacı, proje hakkında birinci bilimsel bilgi sağlamak ve projenin metodolojik, bilimselve uygulama kaynaklı bulgularını tartışarak ortaya koymaktır. Raporun yapısı bu nedenledaha ziyade betimleyicidir ve tarihsel betimleme, sistem modelleme vb. bilimsel yöntem vetekniklerden yararlanır. İçerik çözümleme, dilbilimsel ve bilgi erişim yöntemleri tartışmanınodağında yer almaktadırlar.Content analysis is a

Klassiõpetaja peab särama / Ly Melesk, Kairis Kontus, Leida Talts, Viia Hang...[jt.] ; küsitles Anu Mõttus

Index Scriptorium Estoniae

2007-01-01

Vestlusringis on Tallinna Kuristiku Gümnaasiumi klassiõpetajad Viia Hang ja Ly Melesk, Tallinna Ülikooli 5. kursuse üliõpilane ja Tallinna Lepistiku Lasteaed-Algkooli õpetaja Kairis Kontus, Tallinna Ülikooli algõpetuse õppetooli juhataja Leida Talts ning algõpetuse õppetooli pedagoogika ja algõpetuse metoodika õppejõud Mare Müürsepp. Kui hästi on Tallinna Ülikool ja tema eelkäijad suutnud algklassiõpetajaid ette valmistada ja mis neil igapäevatöös toime tulla aitab

Milliste plaanidega lähed vastu uuele õppeaastale? / Triinu Lepp, Gleb Tšurbanov, Erik Paemurru, Steven Huang...[jt.

Index Scriptorium Estoniae

2008-01-01

Küsimusele vastavad hariduskolleegiumi algkooli 3. klassi õpilane Egert, prantsuse lütseumi 12. klassi õpilane Triinu Lepp, Sillamäe kutsekooli 3. kursuse õpilane Gleb Tšurbanov, Tallinna reaalkooli 11. klassi õpilane Erik Paemurru, Toronto Crescenti keskkooli õpilane Steven Huang, kunstiakadeemia muinsuskaitse- ja restaureerimisosakonna õppejõud Jaan Tamm, Tartu Miina Härma gümnaasiumi 2. a klassi õpilane Erki Külaots, Tallinna 21. kooli 11. klassi õpilane Sander Kaur ja Tapa gümnaasiumi 7. klassi õpilane Evelin Orgse

The M358R variant of α{sub 1}-proteinase inhibitor inhibits coagulation factor VIIa

Energy Technology Data Exchange (ETDEWEB)

Sheffield, William P., E-mail: sheffiel@mcmaster.ca [Canadian Blood Services, Centre for Innovation, Hamilton, Ontario (Canada); Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario (Canada); Bhakta, Varsha [Canadian Blood Services, Centre for Innovation, Hamilton, Ontario (Canada)

2016-02-12

The naturally occurring M358R mutation of the plasma serpin α{sub 1}-proteinase inhibitor (API) changes both its cleavable reactive centre bond to Arg–Ser and the efficacy with which it inhibits different proteases, reducing the rate of inhibition of neutrophil elastase, and enhancing that of thrombin, factor XIa, and kallikrein, by several orders of magnitude. Although another plasma serpin with an Arg–Ser reactive centre, antithrombin (AT), has been shown to inhibit factor VIIa (FVIIa), no published data are available with respect to FVIIa inhibition by API M358R. Recombinant bacterially-expressed API M358R and plasma-derived AT were therefore compared using gel-based and kinetic assays of FVIIa integrity and activity. Under pseudo-first order conditions of excess serpin over protease, both AT and API M358R formed denaturation-resistant inhibitory complexes with FVIIa in reactions accelerated by TF; AT, but not API M358R, also required heparin for maximal activity. The second order rate constant for heparin-independent API M358R-mediated FVIIa inhibition was determined to be 7.8 ± 0.8 × 10{sup 2} M{sup −1}sec{sup −1}. We conclude that API M358R inhibits FVIIa by forming inhibitory complexes of the serpin type more rapidly than AT in the absence of heparin. The likely 20-fold excess of API M358R over AT in patient plasma during inflammation raises the possibility that it could contribute to the hemorrhagic tendencies manifested by rare individuals expressing this mutant serpin. - Highlights: • The inhibitory specificity of the serpin alpha-1-proteinase inhibitor (API) is sharply altered in the M358R variant. • API M358R forms denaturation-resistant complexes with coagulation factor VIIa at a rate accelerated by tissue factor but unaffected by heparin. • Complex formation was shown by gel-based assays and quantified kinetically by inhibition of FVIIa-dependent amidolysis.

Reflectometry observations of density fluctuations in Wendelstein VII-AS stellarator

International Nuclear Information System (INIS)

Sanchez, J.; Hartfuss, H.J.; Anabitarte, E.; Navarro, A.P.

1991-01-01

In the almost shearless stellarator Wendelstein VII-AS strong correlation between the confinement properties and the rotational transform iota has been found. Reduced confinement was observed for the low order rational values 1/2 and 1/3. In their vicinity best confinement is observed. In general optimum confinement is obtained in the low shear configuration if the 'resonant' iota values can be excluded from the plasma column. The iota profile inside the plasma is affected by toroidal currents and beta effects. Although the global net current can be kept at zero level using a small OH induced current opposed to the gradient driven bootstrap current, the different currents flow at different radial positions affecting the iota profile. Tools for configuration control inside the plasma are besides OH current vertical fields and the currents driven by the NBI and most promising the ECH heating systems. In this context experimental information on the iota profile is highly needed. The localization of rational surfaces by reflectometry seems possible. Radially resolved density fluctuation measurements have been carried out by means of a simple microwave reflectometry system. The method is based on the reflection of microwave radiation in the millimeter range at the plasma cutoff layer. (orig./AH)

Impurity transport in the Wendelstein VII-A stellarator

International Nuclear Information System (INIS)

1985-01-01

Impurity radiation losses in net-current-free neutral-beam-heated plasmas in the Wendelstein W VII-A stellarator are the combined effect of particularly strong impurity sources and improved particle confinement as compared with ohmically heated tokamak-like plasma discharges. Experiments are described and conclusions are drawn about the impurity species, their origin and their transport behaviour. The impurity transport is modelled by a 1-D impurity transport and radiation code. The evolution of the total radiation in time and space deduced from soft-X-ray and bolometer measurements can be fairly well simulated by the code. Experimentally, oxygen was found to make the main contribution to the radiation losses. In the calculations, an influx of cold oxygen desorbed from the walls of the order of 10 13 -10 14 cm -2 .s -1 and a rate of fast injected oxygen corresponding to a 1% impurity content of the neutral beams in combination with neoclassical impurity transport leads to quantitative agreement between the simulation and the observed radiation. The transport of A1 trace impurities injected by the laser blow-off technique was experimentally studied by soft-X-ray measurements using a differential method allowing extraction of the time evolution of A1 XII, XIII radial profiles. These are compared with code predictions, together with additional spectroscopic measurements. The main features of the impurity transport are consistent with neoclassical predictions, which explain particularly the central impurity accumulation. Some details, however, seem to require additional 'anomalous' transport. Such an enhancement is correlated with distortions of the magnetic configuration around resonant magnetic surfaces. (author)

ECRH experiments on the W VII-A stellarator

International Nuclear Information System (INIS)

Whilelm, R.; Erckmann, V.; Janzen, G.; Mueller, G.; Schueller, P. G.; Schwoerer, K.; Thumm, H.

1985-01-01

Plasma build-up and heating of a ''currentless'' plasma by means of ECR wave irradiation were studied at the Garching W VII-A stellarator. The experiments were performed at 28 GHz with approx. 200 kW RF power and a pulse duration 02 mode corresponding to a 50% O-mode and 50% X-mode mixture) was launched directly into the plasma from the low field side. In a second step the radiation was converted into the almost linearly polarized TE 11 mode and irradiated in O-mode orientation (E-tilde parallel to B-barsub(o), k-bar perpendicular to B-barsub(o)) into the torus, the nonabsorbed part of the RF power was reflected into the plasma in the X-mode by a focussing polarization twist reflector mounted to the inner torus wall. As a main result the heating efficiency has been slightly improved by the transition from ''simple'' to ''advanced'' wave launching (up to 50% instead of approx. 40%). The central electron temperatures were remarkably increased from approx. 700 eV to 1200 eV due to the well localized O-mode absorption of the TE 11 beam, however. The X-mode from the mirror on the other hand does not contribute to the total plasma energy as expected. This is explained by a local absorption of the arising Bernstein waves due to a macroscopically turbulent behaviour of the plasma in the outer regions. Possibly as a result of wave decay into lower hybrid waves pronounced ion tail heating was observed. For both kinds of wave irradiation toroidal plasma currents were generated. This seems to be caused by asimmetrically confined co- and counter-streaming fast electrons

Postpartum hemorrhage in a Jehovah's Witness patient controlled with Tisseel, tranexamic acid, and recombinant factor VIIa.

Science.gov (United States)

Arab, Tarek Samir; Al-Wazzan, Ahmad Bakr; Maslow, Ken

2010-10-01

The management of a patient refusing blood transfusion who subsequently experiences a severe postpartum hemorrhage is a particular clinical challenge. A 30-year-old nulliparous patient (who was a Jehovah's Witness) had labour induced for post-dates at 41+4 weeks' gestational age after an uncomplicated pregnancy. She delivered by Caesarean section for dystocia and suspected chorioamnionitis, and subsequently developed postpartum hemorrhage that required management with oxytocin, ergometrine, carboprost, uterine artery ligation, and Hayman compression sutures. The patient ultimately required two additional visits to the operating room, culminating in hysterectomy. Use of tranexamic acid, recombinant factor VIIa, and Tisseel was instrumental in halting the ongoing hemorrhage. Optimal management of a patient refusing administration of blood products requires a multidisciplinary approach as well as a combination of traditional and novel therapies.

Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs.

Science.gov (United States)

Yu, Fei; Hao, Shuai; Yang, Bo; Zhao, Yue; Zhang, Wenyue; Yang, Jun

2016-05-01

Mild maternal iron deficiency anemia (IDA) adversely affects the development of cochlear hair cells of the young offspring, but the mechanisms underlying the association are incompletely understood. The aim of this study was to evaluate whether mild maternal IDA in guinea pigs could interrupt inner hair cell (IHC) ribbon synapse density and outer hair cell motility of the offspring. Here, we established a dietary restriction model that allows us to study quantitative changes in the number of IHC ribbon synapses and hearing impairment in response to mild maternal IDA in young guinea pig. The offspring were weaned on postnatal day (PND) 9 and then were given the iron-sufficient diet. On PND 24, pups were examined the hearing function by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) measurements. Then, the cochleae were harvested for assessment of the number of IHC ribbon synapses by immunofluorescence, the morphology of cochlear hair cells, and spiral ganglion cells (SGCs) by scanning electron microscope and hematoxylin-eosin staining, the location, and expression of vesicular glutamate transporter (VGLUT) 3, myosin VIIa, and prestin by immunofluorescence and blotting. Here, we show that mild maternal IDA in guinea pigs induced elevated ABR threshold shifts, declined DPOAE level shifts, and reduced the number of ribbon synapses, impaired the morphology of cochlear hair cells and SGCs in offsprings. In addition, downregulation of VGLUT3 and myosin VIIa, and upregulation of prestin were observed in the cochlea of offsprings from mild maternal IDA in guinea pigs. These data indicate that mild maternal IDA in guinea pigs induced hearing impairment in offsprings, and this deficit may be attributed to the reduction of ribbon synapse density and dysregulation of VGLUT3, myosin VIIa, and prestin.

Identification and biochemical analysis of Slac2-c/MyRIP as a Rab27A-, myosin Va/VIIa-, and actin-binding protein.

Science.gov (United States)

Kuroda, Taruho S; Fukuda, Mitsunori

2005-01-01

Slac2-c/MyRIP is a specific Rab27A-binding protein that contains an N-terminal synaptotagmin-like protein (Slp) homology domain (SHD, a newly identified GTP-Rab27A-binding motif), but in contrast to the Slp family proteins, it lacks C-terminal tandem C2 domains. In vitro Slac2-c simultaneously directly interacts with both Rab27A and an actin-based motor protein, myosin Va, via its N-terminal SHD and middle region, respectively, consistent with the fact that the overall structure of Slac2-c is similar to that of Slac2-a/melanophilin, a linker protein between Rab27A and myosin Va in the melanosome transport in melanocytes. Unlike Slac2-a, however, the middle region of Slac2-c interacts with two types of myosins, myosin Va and myosin VIIa. In addition, the most C-terminal part of both Slac2-a and Slac2-c functions as an actin-binding domain: it directly interacts with globular and fibrous actin in vitro, and the actin-binding domain of Slac2-a and Slac2-c colocalizes with actin filaments when it is expressed in living cells (i.e., PC12 cells and mouse melanocytes). In this chapter we describe the methods that have been used to analyze the protein-protein interactions of Slac2-c, specifically with Rab27A, myosin Va/VIIa, and actin.

Corporate Governance in Post-Socialist Countries - Theoretical Dilemmas, Peculiarities, Research Opportunities / Külliki Tafel, Erik Terk, Alari Purju

Index Scriptorium Estoniae

Tafel, Külliki

2006-01-01

Äriühingute valitsemine postsotsialistlikes riikides - teoreetilised dilemmad, eripärad, uurimisvõimalused. Skeemid: Internal and external relations of corporate governanace; The changing context of corporate governance

Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

DEFF Research Database (Denmark)

Song, Hongjian; Olsen, Ole H; Persson, Egon

2014-01-01

Factor VIIa (FVIIa) is a trypsin-like protease which plays an important role in initiating blood coagulation. Very limited structural information is available for the free, inactive form of FVIIa that circulates in the blood prior to vascular injury and the molecular details of its activity...... signal extends to the EGF1 domain in the light chain of FVIIa, underscoring a remarkable intra- and interdomain allosteric regulation of this trypsin-like protease....

The impact of surface composition on Tafel kinetics leading to enhanced electrochemical insertion of hydrogen in palladium

Science.gov (United States)

Dmitriyeva, Olga; Hamm, Steven C.; Knies, David L.; Cantwell, Richard; McConnell, Matt

2018-05-01

Our previous work experimentally demonstrated the enhancement of electrochemical hydrogen insertion into palladium by modifying the chemical composition of the cathode surface with Pb, Pt and Bi, referred to as surface promoters. The experiment demonstrated that an optimal combination of the surface promoters led to an increase in hydrogen fugacity of more than three orders of magnitude, while maintaining the same current density. This manuscript discusses the application of Density Functional Theory (DFT) to elucidate the thermodynamics and kinetics of observed enhancement of electrochemical hydrogen insertion into palladium. We present theoretical simulations that: (1) establish the elevation of hydrogen's chemical potential on Pb and Bi surfaces to enhance hydrogen insertion, (2) confirm the increase of a Tafel activation barrier that results in a decrease of the reaction rate at the given hydrogen overpotential, and (3) explain why the surface promoter's coverage needs to be non-uniform, namely to allow hydrogen insertion into palladium bulk while simultaneously locking hydrogen below the surface (the corking effect). The discussed DFT-based method can be used for efficient scanning of different material configurations to design a highly effective hydrogen storage system.

Mode and sawtooth behaviour during neutral beam injection in the W VII-A stellarator

International Nuclear Information System (INIS)

Grieger, G.; Renner, H.; Sapper, J.; Wobig, H.; Dorst, D.; Cattanei, G.; Javel, P.; Rau, F.; Zippe, M.; Jaeckel, H.

1980-02-01

The mode behaviour during Neutral Beam Injection in the WENDELSTEIN VII-A stellarator is presented. The analysis is mainly relying on soft X-ray measurements. Two types of discharges were found during Neutral Beam Injection with plasma currents >= 20 kA. The first type is dominated by large, regular and long sawteeth, which are caused by a (m,n) = (1,1) mode. In the second type the sawteeth disappear completely. Later in the discharge a local disruption causes a transition to the first type; this disruption has a (3,2) mode precursor. A new mode (2,2) is found and phase coupled to the (3,2) mode. Even at a high external rotational transform (t 0 = 0.23) a large (2,1) mode is found after the (3,2) mode has caused the local disruption. At slightly lower external rotational transform values major current disruptions may even occur. This is mainly due to the enhanced edge heating by the Neutral Beam Injection. Results of simulations of the mode structures are also presendet. (orig./GG)

Two Finnish USH1B patients with three novel mutations in myosin VIIA.

Science.gov (United States)

Vastinsalo, Hanna; Isosomppi, Juha; Aittakorpi, Anne; Sankila, Eeva-Marja

2006-09-21

Usher syndrome (USH) is an autosomal recessive disorder resulting in retinal degeneration and sensorineural deafness caused by mutations in at least 10 gene loci. USH is divided into three main clinical types: USH1 (33-44%), USH2 (56-67%), and USH3. Worldwide, USH1 and USH2 account for most of the Usher syndrome cases with rare occurrence of USH3. In Finland, however, USH3 is the most common type (40%), explained by genetic and geographical isolation accompanied with a founder mutation, while USH1 is estimated to comprise 34% and USH2 12% of all USH cases. We examined two unrelated Finnish USH1 patients by sequencing. We found three new myosin VIIA (MYO7A) mutations: p.K923AfsX8, p.Q1896X, and p.E1349K. The p.K923AfsX8 mutation was present in both patients as well as in one of 200 Finnish control chromosomes. This is the first molecular genetic study of USH1 in Finland. We have found three new pathological mutations causing either premature termination of translation or replacement of an evolutionary conserved MYO7A amino acid.

Stabilization of the (2,1) tearing mode and of the current disruption in the W VII-A stellarator

International Nuclear Information System (INIS)

Bartlett, D.V.; Cannici, G.; Cattanei, G.

1980-01-01

A numerical code based on a Δ'-analysis is applied to calculate the saturated amplitude of tearing modes dependent on the current density profile. The only stellarator effect included is the additional, shearless external rotational transform in the safety factor profile q(r). In this way, the stellarator field shifts the resonant q=2 surface toward the outside, where the current density gradient is smaller, and stabilizes the (2,1) mode as observed experimentally. Also the measured dependence of the (2,1) mode amplitude on electron density and plasma current can be absolutely predicted by the calculations. - In addition to stabilizing the (2,1) tearing mode, the current disruption is suppressed in Ohmically heated W VII-A discharges for approximately >0.15. The experimental findings, together with the calculated island widths, are compared with the predictions of a theoretical model proposed by several authors to explain the current disruption. (author)

Do all ecosystems maximise their distance with respect to thermodynamic equilibrium? A comment on the Ecological Law of Thermodynamics (ELT, proposed by Sven Erik Jørgensen

Directory of Open Access Journals (Sweden)

Rutger de Wit

2005-09-01

Full Text Available Sven Erik Jørgensen has boldly proposed a “Fourth Law of Thermodynamics” which he also advocates as the “Ecological Law of Thermodynamics” or ELT (Integration of Ecosystem Theories: A Pattern, Kluwer Academic Publisher. This Law is still a hypothesis and can be tested. I disagree with the generalised way he uses the term “exergy” in his approach. Exergy is commonly defined as a measure of the work capacity of a system. According to the physicists Boltzmann information embodies energy. Jørgensen takes this into account when considering the “exergy” stored in ecosystems; hence, according to his way of calculating the genetic information of the organisms is the mayor contribution to “exergy”. I argue that energy has been embodied in the information during a historical process and that because of fundamental irreversibility this energy cannot be extracted again for work capacity. Moreover, other phenomena mentioned earlier by Ramon Margalef, demonstrate that proliferating information in biota shows uncoupling with respect to its embodied energy content according to the Boltzmann formula. In spite of these objections, some of Sven Erik Jørgensen’s core ideas are exiting and worthwhile testing. I place these within the context of the non-equilibrium thermodynamic theories on “dissipative systems” developed by the physicist Ilya Prigogine.

Evolution of radiation losses and importance of charge exchange between plasma impurities and injection beam neutrals in the W VII-A stellarator

International Nuclear Information System (INIS)

Smeulders, P.

1981-01-01

In certain discharges during Neutral Injection (N.I.) (84 0 CO-injection) in the 1 = 2, m = 5 WENDELSTEIN VII-A Stellarator impurity accumulation in the plasma center seems to occur as seen by bolometric, spectroscopic and ultra soft X-ray (USX) measurement. The time evolution of the radiation losses is shown. Three possible sources of the impurities which are responsible for the high central radiation losses are: - Beam injected impurities. - Plasma wall interaction. - Molybdenum protection plates. Possible mechanisms that can be responsible for the central impurity accumulations are: - An inward flow of the plasma or beam impurities. - An increased peaking of the depostion of the beam impurities. Various factors influencing the behaviour of the central radiation are mentioned. (orig./AH)

A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

DEFF Research Database (Denmark)

Olsen, Ole H; Rand, Kasper D; Østergaard, Henrik

2007-01-01

Coagulation factor VIIa (FVIIa) requires tissue factor (TF) to attain full catalytic competency and to initiate blood coagulation. In this study, the mechanism by which TF allosterically activates FVIIa is investigated by a structural dynamics approach that combines molecular dynamics (MD......) simulations and hydrogen/deuterium exchange (HX) mass spectrometry on free and TF-bound FVIIa. The differences in conformational dynamics from MD simulations are shown to be confined to regions of FVIIa observed to undergo structural stabilization as judged by HX experiments, especially implicating activation...... in the presence of TF or an active-site inhibitor. Based on MD simulations, a key switch of the TF-induced structural changes is identified as the interacting pair Leu305{163} and Phe374{225} in FVIIa, whose mutual conformations are guided by the presence of TF and observed to be closely linked to the structural...

Comparative Biochemical and Functional Studies on a Branded Human Recombinant Factor VIIa and a Biosimilar Equivalent Product.

Science.gov (United States)

Sadeghi, Nasiredin; Kahn, Daniel; Syed, Daneyal; Iqbal, Omer; Abro, Schuharazad; Eshraghi, Reza; Hoppensteadt, Debra; Fareed, Jawed

2014-09-01

Recombinant factor VIIa (rFVIIa; NovoSeven, Novo Nordisk, Copenhagen, Denmark) is used to control bleeding in patients with hemophilia. A generic version of FVIIa was developed by AryoGen (Tehran, Iran). This study compared the composition and functional activities of AryoSeven and NovoSeven. Each product was compared at equigravimetric (1 mg/mL) stock solution for protein content. The proteomic profile was obtained using surface-enhanced laser desorption ionization mass spectrometry. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis was carried out to determine the protein profile and Western blotting was performed using a polyclonal rabbit antihuman FVIIa antibody. The FVIIa-related antigen was also measured using a commercially available enzyme-linked immunosorbent assay method. Functional assay included the prothrombin time correction in FVII-deficient plasma. The protein content was comparable in 2 products and the mass spectra analysis showed a single peak at 50 kDa in all products. The SDS-PAGE and immunoblotting studies were comparable. Both products exhibited similar coagulant properties in different assays. © The Author(s) 2014.

Kurumsal içerik yönetimi bileşenlerinin bir savunma sanayii organizasyonu örneğinde değerlendirilmesi = Evaluation of enterprise content management components within the example of defense industry organization

Directory of Open Access Journals (Sweden)

Çakmak, Tolga

2011-01-01

Full Text Available Organizasyonlar doküman, belge, web içerik ve e-posta yönetimi gibi farklı amaçlarla geliştirdikleri bilgi sistemlerini kurumsal içerik yönetimi altında bütünleştirmeye yönelmektedirler. Çalışmamızda bu çerçevede Türkiye'de bir savunma sanayii kuruluşundaki koşulların ve beklentilerin kurumsal içerik yönetimi bileşenleri açısından analiz edilmesi amaçlanmıştır. Belirlenen bu amaç kapsamında geliştirilen web tabanlı bir anket uygulaması ile çalışanların günlük işlerinde kullanmış oldukları doküman yönetimi sistemleri, elektronik posta sistemleri, Web içerik yönetimi uygulamaları ve Evrak/Belge Sistemleri 167 birimden 337 kullanıcı ile analiz edilmiştir. Yapılan analizlere göre; kurumda elektronik posta yönetimi sistemlerinin diğer sistemlere göre daha iyi düzeyde olduğu, en çok kurumsal belge yönetimi sistemlerinin geliştirilmesi, kurumun bütününü kapsayan bir sistem yaklaşımının yapılandırılması ve bu yöndeki farkındalığın artırılması gerektiği vurgulanmıştır. / Organizations tend to integrate the systems, such as document, records, web content and e-mail management that they develop for various purposes under enterprise content management. In this respect, the aim of this study is to analyze the current conditions and expectations of a defense industry organization in Turkey. According to this aim, the document management systems, electronic mail systems, Web content management applications used by the employees while running their day-to-day activities and the document/records systems used for official correspondence in 167 departments by 337 users within an organization specialized in defense industry in Turkey have been analyzed with a web based survey. Results show that the electronic mail management systems in the related organization are at a higher level than the other systems, and records management systems should be developed more than other

Life, limb or off-label recombinant VIIa use in the setting of limited blood assets: a case study.

Science.gov (United States)

Carr, Marcus E; Vickaryous, Brian

2013-06-01

Due to the lack of adequate controlled trials, the off-label use of recombinant factor VIIa (rFVIIa) to control hemorrhage in trauma patients remains controversial. The decision regarding when to initiate rFVIIa therapy is particularly problematic. Whereas most reports and trials have delayed use until significant bleeding has occurred, there is some evidence that coagulopathy develops early in some trauma patients, raising the possibility that early rFVIIa use may be more clinically efficacious. Herein, we report the case of a hemodynamically unstable patient with massive blood loss from multiple gunshot wounds and who had a potentially salvageable upper extremity. Rapid hemorrhage despite efforts to surgically control the bleeding resulted in virtual exhaustion of the facilities' limited blood component supply. Hemorrhage was controlled when rFVIIa was added to hypotensive resuscitation allowing salvage of the arm and significant conservation of blood products. This case raises the question as to whether earlier off-label use of this agent should be considered when amputation for hemorrhage control is being considered and/or conservation of limited blood assets is needed.

Kolm linna ja kolm lähenemist loovusele ja kultuuri arendamisele : Tartu, Turu ja Bergen : loomemajandus / Külliki Tafel, Erik Terk

Index Scriptorium Estoniae

Tafel, Külliki, 1979-

2008-01-01

Tartu, Turu ja Bergen koostasid Põhjamaade Innovatsioonikeskuse projekti "Nordic Model for Creative Industries Development Center" raames oma linnade loomemajanduse arendamise dokumendi. Võrreldakse valminud dokumente

The mother relationship and artistic inhibition in the lives of Leonardo da Vinci and Erik H. Erikson.

Science.gov (United States)

Capps, Donald

2008-12-01

In four earlier articles, I focused on the theme of the relationship of melancholia and the mother, and suggested that the melancholic self may experience humor (Capps, 2007a), play (Capps, 2007b), dreams (Capps, 2008a), and art (Capps, 2008b) as restorative resources. I argued that Erik H. Erikson found these resources to be valuable remedies for his own melancholic condition, which had its origins in the fact that he was illegitimate and was raised solely by his mother until he was three years old, when she remarried. In this article, I focus on two themes in Freud's Leonardo da Vinci and a memory of his childhood (1964): Leonardo's relationship with his mother in early childhood and his inhibitions as an artist. I relate these two themes to Erikson's own early childhood and his failure to achieve his goal as an aspiring artist in his early twenties. The article concludes with a discussion of Erikson's frustrated aspirations to become an artist and his emphasis, in his psychoanalytic work, on children's play.

Cost-utility analysis of an adjunctive recombinant activated factor VIIa for on-demand treatment of bleeding episodes in dengue haemorrhagic fever.

Science.gov (United States)

Naing, Cho; Poovorawan, Yong; Mak, Joon Wah; Aung, Kyan; Kamolratankul, Pirom

2015-06-01

The present study aimed to assess the cost-utility analysis of using an adjunctive recombinant activated factor VIIa (rFVIIa) in children for controlling life-threatening bleeding in dengue haemorrhagic fever (DHF)/dengue shock syndrome (DSS). We constructed a decision-tree model, comparing a standard care and the use of an additional adjuvant rFVIIa for controlling life-threatening bleeding in children with DHF/DSS. Cost and utility benefit were estimated from the societal perspective. The outcome measure was cost per quality-adjusted life years (QALYs). Overall, treatment with adjuvant rFVIIa gained QALYs, but the total cost was higher. The incremental cost-utility ratio for the introduction of adjuvant rFVIIa was $4241.27 per additional QALY. Sensitivity analyses showed the utility value assigned for calculation of QALY was the most sensitive parameter. We concluded that despite high cost, there is a role for rFVIIa in the treatment of life-threatening bleeding in patients with DHF/DSS.

PENERAPAN MODEL PEMBELAJARAN NUMBER HEADS TOGETHER (NHT UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS VIIA SMP NEGERI 2 TUNTANG PADA MATERI SEGITIGA

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Era Destiyandani

2016-12-01

Full Text Available Penelitian tindakan kelas ini bertujuan untuk meningkatkan hasil belajar dan mendeskripsikan kondisi siswa kelas VIIA SMP Negeri 2 Tuntang pada materi segitiga melalui penerapan model pembelajaran Number Heads Together (NHT. Melalui model pembelajaran NHT, tugas diberikan kepada semua siswa dimana siswa telah diberi nomor berbeda didalam kelompoknya namun masing-masing kelompok menggunakan penomoran yang sama. Pemanggilan nomor siswa secara acak untuk melaporkan hasil diskusi kelompok mendorong setiap siswa secara individu bertanggung jawab atas hasil belajarnya. Instrumen penelitian yang digunakan untuk mengambil data penelitian adalah soal tes dan lembar observasi. Penelitian ini diterapkan pada 31 siswa sebagai subjek dan menggunakan model spiral Kemmis dan McTaggart. Hasil penelitian menunjukkan bahwa persentase ketuntasan siswa untuk materi segitiga tentang mengidentifikasi sifat-sifat segitiga berdasarkan sisi dan sudutnya pada siklus I mencapai 87,1% tuntas dan ketuntasan meningkat menjadi 96,77% pada siklus II dengan materi pembelajaran menghitung keliling dan luas segitiga. Hasil ini menunjukkan bahwa penggunaan model pembelajaran NHT telah meningkatkan penguasaan materi segitiga oleh siswa.

Cost effectiveness of recombinant factor VIIa for treatment of intracerebral hemorrhage

Directory of Open Access Journals (Sweden)

Eckman Mark H

2008-05-01

Full Text Available Abstract Background Phase I/II placebo-controlled clinical trials of recombinant Factor VIIa (rFVIIa suggested that administration of rFVIIa within 4 hours after onset of intracerebral hemorrhage (ICH is safe, limits ICH growth, and improves outcomes. We sought to determine the cost-effectiveness of rFVIIa for acute ICH treatment, using published Phase II data. We hypothesized that rFVIIa would have a low marginal cost-effectiveness ratio (mCER given the poor neurologic outcomes after ICH with conventional management. Methods We performed an incremental cost-effectiveness analysis from the societal perspective, considering conventional management vs. 80 ug/kg rFVIIa treatment for acute ICH cases meeting Phase II inclusion criteria. The time frame for the analysis was 1. 25 years: data from the Phase II trial was used for 90 day outcomes and rFVIIa complications – arterial thromboembolic events (ATE. We assumed no substantial cost differences in care between the two strategies except: 1 cost of rFVIIa (for an 80 mcg/kg dose in an 80 kg patient, assumed cost of $6,408; 2 cost of ATE side effects from rFVIIa (which also decrease quality of life and increase the chance of death; and 3 differential monetary costs of outcomes and their impact on quality of life, including disposition (home vs. nursing home, and outpatient vs. inpatient rehabilitation. Sensitivity analyses were performed to explore uncertainty in parameter estimates, impact of rFVIIa cost, direct cost of neurologic outcomes, probability of ATE, and outcomes after ATE. Results In the "base case", treating ICH with rFVIIa dominates the usual care strategy by being more effective and less costly. rFVIIa maintained a mCER Conclusion Based on data from preliminary trials, treating selected ICH patients with rFVIIa results in lower cost and improved clinical outcomes. This potential cost-effectiveness must be considered in light of the Phase III trial results.

Televizyon ve internette yayınlanan spor içerikli reklamların göstergebilim açısından incelenmesi

OpenAIRE

ÜNAL, Hakan; ÇEVİK, Ali

2018-01-01

Amaç: Bu çalışmanın amacı, 2013-2015 yılları arasında televizyon ve internette yayınlanan spor içerikli reklamlar arasından seçilen 5 tanesinin göstergebilimsel açıdan incelenmesidir.Materyal ve Yöntem: Çalışmada ortaya konulan hipotezler Barthes tarafından tanımlanmış olan göstergebilimsel çözümleme yöntemi ile incelenmiştir. Roland Barthes’in sunduğu üç önemli yöntem olan şifrelenmiş görüntüsel ileti (yan anlam), şifrelenmemiş görüntüsel ileti (gerçeğe benzerlik, düz anlam), ve dilsel ileti...

Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa

Science.gov (United States)

Nayak, Ramesh C.; Keshava, Shiva; Esmon, Charles T.; Pendurthi, Usha R.; Rao, L. Vijaya Mohan

2013-01-01

Recent studies have established that factor VIIa (FVIIa) binds to the endothelial cell protein C receptor (EPCR). FVIIa binding to EPCR may promote the endocytosis of this receptor/ligand complex. Rab GTPases are known to play a crucial role in the endocytic and exocytic pathways of receptors or receptor/ligand complexes. The present study was undertaken to investigate the role of Rab GTPases in the intracellular trafficking of EPCR and FVIIa. CHO-EPCR cells and human umbilical vein endothelial cells (HUVEC) were transduced with recombinant adenoviral vectors to express wild-type, constitutively active, or dominant negative mutant of various Rab GTPases. Cells were exposed to FVIIa conjugated with AF488 fluorescent probe (AF488-FVIIa), and intracellular trafficking of FVIIa, EPCR, and Rab proteins was evaluated by immunofluorescence confocal microscopy. In cells expressing wild-type or constitutively active Rab4A, internalized AF488-FVIIa accumulated in early/sorting endosomes and its entry into the recycling endosomal compartment (REC) was inhibited. Expression of constitutively active Rab5A induced large endosomal structures beneath the plasma membrane where EPCR and FVIIa accumulated. Dominant negative Rab5A inhibited the endocytosis of EPCR-FVIIa. Expression of constitutively active Rab11 resulted in retention of accumulated AF488-FVIIa in the REC, whereas expression of a dominant negative form of Rab11 led to accumulation of internalized FVIIa in the cytoplasm and prevented entry of internalized FVIIa into the REC. Expression of dominant negative Rab11 also inhibited the transport of FVIIa across the endothelium. Overall our data show that Rab GTPases regulate the internalization and intracellular trafficking of EPCR-FVIIa. PMID:23555015

Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

DEFF Research Database (Denmark)

Hjortoe, Gertrud M; Petersen, Lars C; Albrektsen, Tatjana

2004-01-01

Tissue factor (TF), the cellular receptor for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role in tissue repair, inflammation, angiogenesis, and tumor metastasis. Like TF, the chemokine interleukin-8 (IL-8) is shown to play a critical role...... in these processes. To elucidate the potential mechanisms by which TF contributes to tumor invasion and metastasis, we investigated the effect of FVIIa on IL-8 expression and cell migration in a breast carcinoma cell line, MDA-MB-231, a cell line that constitutively expresses abundant TF. Expression of IL-8 m......RNA in MDA-MB-231 cells was markedly up-regulated by plasma concentrations of FVII or an equivalent concentration of FVIIa (10 nM). Neither thrombin nor other proteases involved in hemostasis were effective in stimulating IL-8 in these cells. Increased transcriptional activation of the IL-8 gene...

Fen Eğitiminde Proje Tabanlı Öğretimle İlgili Tezlerin İçerik Analizi: Türkiye Örneği (2002-2014)

OpenAIRE

YAVUZ, Soner; YAVUZ, Gonca

2017-01-01

Ülkemizde 2000’li yılların başlarından itibaren, Proje Tabanlı Öğretim (PTÖ) hakkında yüksek lisans ve doktora tez çalışmaları tamamlanmaya başlamıştır. Günümüze kadar olan süreçte çok sayıda araştırma yapılmış olması konu hakkında genel çerçevenin belirlenmesi ihtiyacını ortaya çıkarmıştır. Araştırmada, Türkiye’de 2002 ve 2014 yılları arasında fen eğitimi alanındaki PTÖ konusuyla ilgili tamamlanmış yüksek lisans ve doktora tezleri üzerine bir içerik analizi yapılmıştır. Araştırma kapsamına a...

Tumor Angiogenesis Therapy Using Targeted Delivery of Paclitaxel to the Vasculature of Breast Cancer Metastases

Directory of Open Access Journals (Sweden)

Shijun Zhu

2014-01-01

Full Text Available Breast cancer aberrantly expresses tissue factor (TF in cancer tissues and cancer vascular endothelial cells (VECs. TF plays a central role in cancer angiogenesis, growth, and metastasis and, as such, is a target for therapy and drug delivery. TF is the cognate receptor of factor VIIa (fVIIa. We have coupled PTX (paclitaxel, also named Taxol with a tripeptide, phenylalanine-phenylalanine-arginine chloromethyl ketone (FFRck and conjugated it with fVIIa. The key aim of the work is to evaluate the antiangiogenic effects of PTX-FFRck-fVIIa against a PTX-resistant breast cancer cell line. Matrigel mixed with VEGF and MDA-231 was injected subcutaneously into the flank of athymic nude mice. Animals were treated by tail vein injection of the PTX-FFRck-fVIIa conjugate, unconjugated PTX, or PBS. The PTX-FFRck-fVIIa conjugate significantly reduces microvessel density in matrigel (p<0.01–0.05 compared to PBS and unconjugated PTX. The breast cancer lung metastasis model in athymic nude mice was developed by intravenous injection of MDA-231 cells expressing luciferase. Animals were similarly treated intravenously with the PTX-FFRck-fVIIa conjugate or PBS. The conjugate significantly inhibits lung metastasis as compared to the control, highlighting its potential to antagonize angiogenesis in metastatic carcinoma. In conclusion, PTX conjugated to fVIIa is a promising therapeutic approach for improving selective drug delivery and inhibiting angiogenesis.

FVIIa-sTF and Thrombin Inhibitory Activities of Compounds Isolated from Microcystis aeruginosa K-139

Directory of Open Access Journals (Sweden)

Andrea Roxanne J. Anas

2017-08-01

Full Text Available The rise of bleeding and bleeding complications caused by oral anticoagulant use are serious problems nowadays. Strategies that block the initiation step in blood coagulation involving activated factor VII-tissue factor (fVIIa-TF have been considered. This study explores toxic Microcystis aeruginosa K-139, from Lake Kasumigaura, Ibaraki, Japan, as a promising cyanobacterium for isolation of fVIIa-sTF inhibitors. M. aeruginosa K-139 underwent reversed-phase solid-phase extraction (ODS-SPE from 20% MeOH to MeOH elution with 40%-MeOH increments, which afforded aeruginosin K-139 in the 60% MeOH fraction; micropeptin K-139 and microviridin B in the MeOH fraction. Aeruginosin K-139 displayed an fVIIa-sTF inhibitory activity of ~166 µM, within a 95% confidence interval. Micropeptin K-139 inhibited fVIIa-sTF with EC50 10.62 µM, which was more efficient than thrombin inhibition of EC50 26.94 µM. The thrombin/fVIIa-sTF ratio of 2.54 in micropeptin K-139 is higher than those in 4-amidinophenylmethane sulfonyl fluoride (APMSF and leupeptin, when used as positive controls. This study proves that M. aeruginosa K-139 is a new source of fVIIa-sTF inhibitors. It also opens a new avenue for micropeptin K-139 and related depsipeptides as fVIIa-sTF inhibitors.

Dicty_cDB: AFL324 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available mmeikmek*l*mkllnflkgwdqniqrnvqlyy lkcmi*imkekfhmmkfrkkylkdikik*erik*nnifkmilkhfy*dmikieiielilk nlnnvlkvlvqii...e B: nnnkhtcqeymnk*kkmlkk*lvnmmeikmek*l*mkllnflkgwdqniqrnvqlyylkc mi*imkekfhmmkfrkkylkdikik*erik*nnifkmilk...k*nkktniyviif*kk--- ---NNNKHTCQEYMNK*kkmlkk*lvnmmeikmek*l*mkllnflkgwdqniqrnvqlyy lkcmi*imkekfhmmkfrkkylkdikik*erik*nnifkmilk

Role of hepsin in factor VII activation in zebrafish.

Science.gov (United States)

Khandekar, Gauri; Jagadeeswaran, Pudur

2014-01-01

Factor VII, the initiator of the extrinsic coagulation cascade, circulates in human plasma mainly in its zymogen form, factor VII and in small amounts in its activated form, factor VIIa. However, the mechanism of initial generation of factor VIIa is not known despite intensive research using currently available model systems. Earlier findings suggested serine proteases factor VII activating protease and hepsin play a role in activating factor VII, however, it has remained controversial. In this paper we estimated the levels of factor VIIa and factor VII for the first time in zebrafish adult population and also reevaluated the role of the above two serine proteases in activating factor VII in vivo using zebrafish as a model system. Knockdown of factor VII activating protease and hepsin was performed followed by assaying for their effect on factor VIIa concentration and extrinsic coagulation as measured by the kinetic prothrombin time. Factor VII activating protease knockdown showed no change in kinetic prothrombin time and no effect on factor VIIa levels while hepsin knockdown increased the kinetic prothrombin time and significantly reduced the factor VIIa plasma levels. Our results thus indicate that hepsin plays a physiologically important role in factor VII activation and hemostasis in zebrafish. © 2013.

Thromboembolic risks of recombinant factor VIIa Use in warfarin-associated intracranial hemorrhage: a case–control study

Directory of Open Access Journals (Sweden)

H-Y Chou Sherry

2012-12-01

Full Text Available Abstract Background Recombinant factor VIIa (rFVIIa may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH, FVIIa use is controversial and may carry significant thromboembolic risks. We compared incidence of baseline thromboembolic risk factors and thromboembolism rates in wICH patients treated with additional rFVIIa to those treated with standard therapy of fresh frozen plasma (FFP and vitamin K alone. Methods We identified 45 consecutive wICH patients treated with additional rFVIIa over 5-year period, and 34 consecutive wICH patients treated with standard therapy alone as comparison group. We compared the incidence of post-hemorrhage cardiac and extra-cardiac thromboembolic complications between two treatment groups, and used logistic regression to adjust for significant confounders such as baseline thromboembolic risk factors. We performed secondary analysis comparing the quantity of FFP transfused between two treatment cohorts. Results Both rFVIIa-treated and standard therapy-treated wICH patients had a high prevalence of pre-existing thromboembolic diseases including atrial fibrillation (73% vs 68%, deep venous thrombosis (DVT or pulmonary embolism (PE (22% vs 18%, coronary artery disease (CAD (38% vs 32%, and abnormal electrocardiogram (EKG (78% vs 85%. Troponin elevation following wICH was prevalent in both groups (47% vs 41%. Clinically significant myocardial infarction (MI, defined as troponin > 1.0 ng/dL, occurred in 13% of rFVIIa-treated and 6% of standard therapy-treated patients (p=0.52. Past history of CAD (p=0.0061 and baseline abnormal EKG (p=0.02 were independently associated with clinically significant MI following wICH while rFVIIa use was not. The incidences of DVT/PE (2% vs 9%; p=0.18 and ischemic stroke (2% vs 0%; p=0.38 were similar between two treatment groups. Recombinant FVIIa-treated patients had lower mean INR at 3 (p=0.0001 and 6 hours (p Conclusions Pre

Romaanirindel muutustega / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

2001-01-01

Romaanivõistluse võitjatest: I koht - Aarne Rubeni ""Volta" annab kaeblikku vilet"; II koht - Leo Kunnase "Sõdurjumala teener"; III koht - Maimu Veske "Continental" ja Lehte Hainsalu "Kellakuuljad"; Ulmekirjanduse eripreemia Varrakult - Indrek Hargla "Baiita needus". Esiletõstetud tööd: Lembit Uustulndi "Süvameri"; Wimbergi [Jaak Urmet] "Lipamäe"; Maarja Oderi "Inglinägu"; Aarne Biini "Kuningavesi"; Reet Kudu "Täiskuu ja tänavalatern"; Erik Tohvri [Hans-Erik Laansalu] "Majad jõe ääres"; Tambet Tamme "Suur tühemik"; Erik Tohvri [Hans-Erik Laansalu] "Kollaste lehtede aegu"; Maniakkide tänav, pseud. "Mu aknad on puust..."

Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.

Science.gov (United States)

Song, Hongjian; Olsen, Ole H; Persson, Egon; Rand, Kasper D

2014-12-19

Factor VIIa (FVIIa) is a trypsin-like protease that plays an important role in initiating blood coagulation. Very limited structural information is available for the free, inactive form of FVIIa that circulates in the blood prior to vascular injury and the molecular details of its activity enhancement remain elusive. Here we have applied hydrogen/deuterium exchange mass spectrometry coupled to electron transfer dissociation to pinpoint individual residues in the heavy chain of FVIIa whose conformation and/or local interaction pattern changes when the enzyme transitions to the active form, as induced either by its cofactor tissue factor or a covalent active site inhibitor. Identified regulatory residues are situated at key sites across one continuous surface of the protease domain spanning the TF-binding helix across the activation pocket to the calcium binding site and are embedded in elements of secondary structure and at the base of flexible loops. Thus these residues are optimally positioned to mediate crosstalk between functional sites in FVIIa, particularly the cofactor binding site and the active site. Our results unambiguously show that the conformational allosteric activation signal extends to the EGF1 domain in the light chain of FVIIa, underscoring a remarkable intra- and interdomain allosteric regulation of this trypsin-like protease. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Ortaokul 5. ve 6. Sınıf Fen Bilimleri Öğretim Programının Kazanım ve İçerik İlişkisinin Değerlendirilmesi

OpenAIRE

Ocak, Gürbüz; Kutlu Kalender, M. Damla

2018-01-01

Bu çalışma Milli Eğitim Bakanlığı tarafından basılmış 5. ve 6. Sınıf Fen Bilimleri ders kitaplarındaki içeriğin, ortaokul 5. ve 6. Sınıf Fen Bilimleri dersi öğretim programındaki kazanımlara uygunluk düzeyini değerlendirmeyi amaçlamıştır. Öncelikle 2015-2016 eğitim öğretim yılı 5. ve 6.sınıf öğretim programındaki kazanımlarla 5.ve 6. sınıf fen bilimleri ders kitaplarındaki içerikler incelenmiştir. Değerlendirme için ölçme aracı olarak kazanım-içerik değerlendirme rubriği hazırlanmıştır. Geliş...

Nationale test

DEFF Research Database (Denmark)

2009-01-01

Professor Sven Erik Nordenbo og centerleder Niels Egelund, begge DPU, i samtale om nationale test.......Professor Sven Erik Nordenbo og centerleder Niels Egelund, begge DPU, i samtale om nationale test....

Subtle, yet radical in Kongens Have, Odense (DK)

DEFF Research Database (Denmark)

Vera Bardeloch, Noldus; Riesto, Svava

2014-01-01

Review of revitalization of historical garden in Odense city centre, by Erik Brandt Dam Arkitekter.......Review of revitalization of historical garden in Odense city centre, by Erik Brandt Dam Arkitekter....

Dostojevskilik kapseldunud elu Q-teatris / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres

1997-01-01

Fjodor Dostojevski jutustuse 'Ülestähendusi põranda alt' järgi tehtud Soome Q-teatri lavastusest 'Kelder' ("Kellari", dramatiseerinud Antti Hietala, Hannu Kivioja ja Erik Söderblom, lav. Erik Söderblom)

Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells.

Science.gov (United States)

Yokota, N; Koizume, S; Miyagi, E; Hirahara, F; Nakamura, Y; Kikuchi, K; Ruf, W; Sakuma, Y; Tsuchiya, E; Miyagi, Y

2009-12-15

Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to activation of the extrinsic coagulation cascade. fVII is produced by the liver and believed to be supplied from blood plasma at the site of coagulation. However, we recently showed that ovarian cancer cells express fVII transcripts under normoxia and that this transcription is inducible under hypoxia. These findings led us to hypothesise that ovarian cancer cells are intrinsically associated with TF-fVIIa coagulation activity, which could result in thrombosis. In this study, we examined whether ectopically expressed fVII could cause thrombosis by means of immunohistochemistry, RT-PCR, western blotting and flow cytometry. Ectopic fVII expression occurs frequently in ovarian cancers, particularly in clear cell carcinoma. We further showed that ovarian cancer cells express TF-fVIIa on the cell surface under normoxia and that this procoagulant activity is enhanced by hypoxic stimuli. Moreover, we showed that ovarian cancer cells secrete microparticles (MPs) with TF-fVIIa activity. Production of this procoagulant secretion is enhanced under hypoxia. These results raise the possibility that cancer cell-derived TF-fVIIa could cause thrombotic events in ovarian cancer patients.

RECOMBINANT FACTOR VIIa – NEW TREATMENT OPTION FOR CONTROL OF INTRACTABLE BLEEDING IN SURGICAL AND TRAUMA PATIENTS AND IN OTHER HAEMOSTASIS DISORDERS

Directory of Open Access Journals (Sweden)

Samo Zver

2004-12-01

Full Text Available Background. Recombinant factor VIIa (rFVIIa, which is currently registered only for the treatment of haemophilia A and B patients with inhibitors, is seen increasingly as a possible universal haemostatic agent in untractable bleedings. One possible mechanism for the efficacy rFVIIa may be a consequence of it’s from the tissue factor (TF and from the level of disfunction in haemostatic system independant activity, which generates »thrombin burst« formation. It seems that rFVIIa remains active only at the site of tissue injury/bleeding.Conclusions. There are two components of bleeding in surgery and trauma patients. One is bleeding from large calibre arteries and veins which requires surgical intervention. The other, which goes along with the first one, is coagulopathic bleeding. The latter is a consequence of consumptional and dilutional coagulopathy, hypothermia, multitransfusion syndrom and metabolic disbalances in patients. rFVIIa effects coagulopathic component of the bleeding. For effective treatment with rFVIIa in such patients, replacement therapy with erythrocytes, platelets and fresh frozen plasma is mandatory and requires a haematologist assistance in the treatment strategy.Most reported cases of effective rFVIIa usage are from the field of traumatology. Until now, there have been no universal recommendations when to start treatment with rFVIIa in a bleeding trauma patient. Most experience with rFVIIa are from Israel and their recommendations are perhaps the most valuable ones. rFVIIa was used several times during intra-operative and post-operative bleeding episodes. There are reports of clinical studies and usage in patients with/ after prostate surgery, cardiovascular operations and liver transplants.There are data about effective rFVIIa usage in neurology and neurosurgery patients (intracranial haemorrhages, obstetrics and gynecology field. Possible future indications are thrombocytopenias, thrombocytopathias (Glanzmann

Peter Petersen & Co. A/S

DEFF Research Database (Denmark)

Nygaard, Erik

1986-01-01

Peter Petersen & Co. A/S : administrations- og lagerbygning kommenteret af: Erik Nygaard. Resumé på engelsk & tysk.......Peter Petersen & Co. A/S : administrations- og lagerbygning kommenteret af: Erik Nygaard. Resumé på engelsk & tysk....

Eesti etümoloogia sõnaraamat / Gábor Zaicz

Index Scriptorium Estoniae

Zaicz, Gábor

2013-01-01

Arvustus: Metsmägi, Iris, Sedrik, Meeli, Soosaar, Sven-Erik. Eesti etümoloogia sõnaraamat. Peatoimetaja Iris Metsmägi. Koostanud ja toimetanud Iris Metsmägi, Meeli Sedrik, Sven-Erik Soosaar. Eesti Keele Sihtasutus. Tallinn, 2012

En ny flugt ind i skoven

DEFF Research Database (Denmark)

Haarder, Jon Helt

2008-01-01

Thure Erik Lund: IND. (Inn). Oversat fra norsk af Sara Koch. 192 sider, 199 kr. Gyldendal. UDKOMMER I DAG. Fire stjerner......Thure Erik Lund: IND. (Inn). Oversat fra norsk af Sara Koch. 192 sider, 199 kr. Gyldendal. UDKOMMER I DAG. Fire stjerner...

Nineteenth-Century English

DEFF Research Database (Denmark)

Fabricius, Anne

2009-01-01

The article reviews the book "Nineteenth-Century English: Stability and Change," by Merja Kytö, Mats Rydèn and Erik Smitterberg......The article reviews the book "Nineteenth-Century English: Stability and Change," by Merja Kytö, Mats Rydèn and Erik Smitterberg...

Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor

International Nuclear Information System (INIS)

Repke, D.; Gemmell, C.H.; Guha, A.; Turitto, V.T.; Nemerson, Y.; Broze, G.J. Jr.

1990-01-01

The effect of factors VIII and IX on the ability of the tissue factor-factor VIIa complex to activate factor X was studied in a continuous-flow tubular enzyme reactor. Tissue factor immobilized in a phospholipid bilayer on the inner surface of the tube was exposed to a perfusate containing factors VIIa, VIII, IX, and X flowing at a wall shear rate of 57, 300, or 1130 sec -1 . The addition of factors VIII and IX at their respective plasma concentrations resulted in a further 2 endash-to 3 endash fold increase. The direct activation of factor X by tissue factor-factor VIIa could be virtually eliminated by the lipoprotein-associated coagulation inhibitor. These results suggest that the tissue factor pathway, mediated through factors VIII and IX, produces significant levels of factor Xa even in the presence of an inhibitor of the tissue factor-factor VIIa complex; moreover, the activation is dependent on local shear conditions. These findings are consistent both with a model of blood coagulation in which initiation of the system results from tissue factor and with the bleeding observed in hemophilia

Interaction Between Hippocampus and Cerebellum Crus I in Sequence-Based but not Place-Based Navigation

Science.gov (United States)

Iglói, Kinga; Doeller, Christian F.; Paradis, Anne-Lise; Benchenane, Karim; Berthoz, Alain; Burgess, Neil; Rondi-Reig, Laure

2015-01-01

To examine the cerebellar contribution to human spatial navigation we used functional magnetic resonance imaging and virtual reality. Our findings show that the sensory-motor requirements of navigation induce activity in cerebellar lobules and cortical areas known to be involved in the motor loop and vestibular processing. By contrast, cognitive aspects of navigation mainly induce activity in a different cerebellar lobule (VIIA Crus I). Our results demonstrate a functional link between cerebellum and hippocampus in humans and identify specific functional circuits linking lobule VIIA Crus I of the cerebellum to medial parietal, medial prefrontal, and hippocampal cortices in nonmotor aspects of navigation. They further suggest that Crus I belongs to 2 nonmotor loops, involved in different strategies: place-based navigation is supported by coherent activity between left cerebellar lobule VIIA Crus I and medial parietal cortex along with right hippocampus activity, while sequence-based navigation is supported by coherent activity between right lobule VIIA Crus I, medial prefrontal cortex, and left hippocampus. These results highlight the prominent role of the human cerebellum in both motor and cognitive aspects of navigation, and specify the cortico-cerebellar circuits by which it acts depending on the requirements of the task. PMID:24947462

Recombinant Activated Factor VIIa (rFVIIa) Treatment in Very-Low-Birth-Weight (VLBW) Premature Infants with Acute Pulmonary Hemorrhage: A Single-Center, Retrospective Study.

Science.gov (United States)

Cosar, Hese; Isik, Halil; Cakır, Salih Cagrı; Yar, Nese; Goksen, Bulent; Tokbay, Hakan; Kertmen, Hasan; Erdoğan, Nihal; Durak, Ikbal

2017-02-01

We aimed to evaluate the efficacy of intravenous administration of recombinant activated factor VIIa (rFVIIa) for acute pulmonary hemorrhage treatment in very-low-birth-weight (VLBW) premature infants. This study was carried out retrospectively in premature infants with pulmonary hemorrhage that were ≤30 weeks gestational age or hemorrhage who were hospitalized in our neonatal intensive care unit between 01 January 2013 and 31 December 2015 were evaluated. Group 1 (n = 21) received rFVIIa support within the first 30 min of pulmonary hemorrhage plus conventional treatment, while Group 2 (n = 21) received conventional treatment only. The number of patients whose pulmonary hemorrhage was stopped within the first 2 h was significantly higher in Group 1 than Group 2 (n = 14 vs n = 4; p = 0.002). After pulmonary hemorrhage, hemoglobin values of Group 1 were higher than Group 2 (11.12 ± 1.06 vs 10.14 ± 1.59 g/dL; p = 0.024). Erythrocyte suspension (1.43 ± 4.51 vs 5.71 ± 7.46 mL/kg; p = 0.030) and fresh frozen plasma use (5.71 ± 8.10 vs 19.52 ± 12.44 mL/kg; p hemorrhage after 72 h, overall mortality, mortality from pulmonary hemorrhage, surfactant use, intubation time, hospitalization duration, intraventricular hemorrhage (IVH), severe IVH, patent ductus arteriosus rates, or short-term complication rates. rFVIIa administration was observed to be effective in stopping pulmonary hemorrhage, reducing blood product requirement, and improving coagulation test parameters. Prospective studies are needed to evaluate the efficacy, reliability, and long-term results of rFVIIa in the prevention and treatment of pulmonary hemorrhage in premature infants.

Postprandial triglycerides and blood coagulation.

Science.gov (United States)

Silveira, A

2001-01-01

Most of our lifetime we spend in the postprandial state. Postprandial triglyceridemia may represent a procoagulant state involving disturbances of both blood coagulation and fibrinolysis, in particular due to elevation of the plasma levels of activated factor VII (VIIa) and plasminogen activator inhibitor (PAI-1). Therefore, disturbances of the hemostatic system might, at least partly, account for by the link between hypertriglyceridemia and coronary heart disease (CHD). Factor VIIa is the first enzyme of the blood coagulation system and serves a priming function for triggering of the clotting cascade. The coagulant activity of factor VII (VIIc, total activity of factor VII in plasma) was identified as an independent predictor of myocardial infarction in initially healthy middle-aged men, and particularly of fatal coronary events, and both serum cholesterol and triglyceride concentrations correlated positively with the VIIc level. Addition of fat to diet has been consistently shown to cause a rapid conversion of the factor VII zymogen into its active form (VIIa) whereas the concentration of total protein is unaffected. Postprandial activation of factor VII is dependent on lipolytic activity and it is mainly supported by large triglyceride-rich lipoprotein of the VLDL class. Studies in vivo with specific coagulation factor-deficient patients indicate that factor IX is essential for the postprandial activation of factor VII. The basal generation of thrombin seems to be unaffected by increased plasma levels of VIIa. However, since VIIa-tissue factor complex is responsible for the initiation of the coagulation cascade, increased generation of VIIa in the postprandial state would increase the potential for thrombin production in the event of plaque rupture. Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of the plasminogen activators in the circulation and thereby the principal inhibitor of the fibrinolytic system. Postprandial

Lyset og livet

DEFF Research Database (Denmark)

Oxenvad, Carsten Michael

2003-01-01

Beskrivelse af Øster Aaby Friskole og friskoler generelt. Blandt bidragyderne: Susanne Eskildsen, Holger Henriksen, Margrethe Vestager, John Iversen, Thorstein Balle og Poul Erik Søe......Beskrivelse af Øster Aaby Friskole og friskoler generelt. Blandt bidragyderne: Susanne Eskildsen, Holger Henriksen, Margrethe Vestager, John Iversen, Thorstein Balle og Poul Erik Søe...

Musik går direkte i kroppen

DEFF Research Database (Denmark)

Christensen, Erik

2016-01-01

Erik Christensen, som er musikforsker, indkredser på kort form her, hvad neurovidenskaben foreløbigt kan sige om effekten af at musicere og lytte til musik......Erik Christensen, som er musikforsker, indkredser på kort form her, hvad neurovidenskaben foreløbigt kan sige om effekten af at musicere og lytte til musik...

Eriks Stendzenieks - 100% brain product / Eriks Stendzenieks ; interv. Alina Lisina

Index Scriptorium Estoniae

Stendzenieks, Eriks

2004-01-01

Läti reklaamiagentuuri Zoom juht reklaami väärtusest, konkurentsist, põhimõtetest, mainest, klientidega suhtlemisest, loovusest, rahvusvahelise agentuuri loomise positiivsetest ning negatiivsetest külgedest, reklaamikampaaniates osalemisest

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

propanol in 0.5 M H2SO4 were investigated with Pt and PtRu electrodes. Tafel slope and apparent activation energy were evaluated from the cyclic voltammetric data in the low potential region (0.3-0.5 V vs SHE). The CV results provided Tafel ...

Relationship between Inflammation markers, Coagulation Activation and Impaired Insulin Sensitivity in Obese Healthy Women

International Nuclear Information System (INIS)

Soliman, S.Et; Shousha, M.A.

2011-01-01

Obesity, insulin resistance syndrome, and atherosclerosis are closely linked phenomena, often connected with a chronic low grade inflammatory state and pro thrombotic hypo fibrinolytic condition. This study investigated the relationship between impaired insulin sensitivity and selected markers of inflammation and thrombin generation in obese healthy women. The study included 36 healthy obese women (body mass index ≥ 30), with normal insulin sensitivity (NIS, n = 18) or impaired insulin sensitivity (IIS, n 18), and 10 non obese women (body mass index < 25).Impaired insulin sensitivity patients had significantly higher levels of high sensitivity C-reactive protein (hs-CRP), transforming growth factor -β1(TGF-β1), plasminogen activator inhibitor-1 (PAI-1), activated factor VII (VIIa), and prothrombin fragments 1 + 2 (F1 + 2) compared with either control subjects or normal insulin sensitivity patients. On the other hand, NIS patients had higher hs-CRP, TGF-β1, PAI-1, and factor VIIa, but not F1 + 2, levels than controls. Significant inverse correlations were observed between the insulin sensitivity index and TGF-β1, hs-CRP, PAI-1; factor VIIa, and F1 + 2 levels. Moreover, significant direct correlations were noted between TGF-β1 and CRP, PAI-1, factor VIIa, and F1 + 2 concentrations. Finally, multiple regressions revealed that TGF-β1 and the insulin sensitivity index were independently related to F1 + 2. These results document an in vivo relationship between insulin sensitivity and coagulation activation in obesity. Here we report that obesity is associated with higher TGF-β, PAI-1, prothrombin fragments 1 and 2 (F1 + 2), and activated factor VII (VIIa) plasma levels, and that insulin resistance exacerbates these alterations. The elevated TGF-β1 levels detected in the obese population may provide a biochemical link between insulin resistance and an increased risk for cardiovascular disease

The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells.

Science.gov (United States)

Zou, Junhuang; Chen, Qian; Almishaal, Ali; Mathur, Pranav Dinesh; Zheng, Tihua; Tian, Cong; Zheng, Qing Y; Yang, Jun

2017-02-01

Usher syndrome (USH) is the most common cause of inherited deaf-blindness, manifested as USH1, USH2 and USH3 clinical types. The protein products of USH2 causative and modifier genes, USH2A, ADGRV1, WHRN and PDZD7, interact to assemble a multiprotein complex at the ankle link region of the mechanosensitive stereociliary bundle in hair cells. Defects in this complex cause stereociliary bundle disorganization and hearing loss. The four USH2 proteins also interact in vitro with USH1 proteins including myosin VIIa, USH1G (SANS), CIB2 and harmonin. However, it is unclear whether the interactions between USH1 and USH2 proteins occur in vivo and whether USH1 proteins play a role in USH2 complex assembly in hair cells. In this study, we identified a novel interaction between myosin VIIa and PDZD7 by FLAG pull-down assay. We further investigated the role of the above-mentioned four USH1 proteins in the cochlear USH2 complex assembly using USH1 mutant mice. We showed that only myosin VIIa is indispensable for USH2 complex assembly at ankle links, indicating the potential transport and/or anchoring role of myosin VIIa for USH2 proteins in hair cells. However, myosin VIIa is not required for USH2 complex assembly in photoreceptors. We further showed that, while PDZ protein harmonin is not involved, its paralogous USH2 proteins, PDZD7 and whirlin, function synergistically in USH2 complex assembly in cochlear hair cells. In summary, our studies provide novel insight into the functional relationship between USH1 and USH2 proteins in the cochlea and the retina as well as the disease mechanisms underlying USH1 and USH2. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2003-01-01

Heliplaatidest: Red Hot Chili Peppers "Greatest Hits", G-Unit "Beg For Mercy", The Desert Sessions "The Desert Sessions 9 & 10", Freg Nasty "Bring Me the Head of Freg Nasty", Peter Gabriel "Hit", Michael Jackson "Number Ones"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2007-01-01

Heliplaatidest: The Killers "Sawdust", Forgotten Sunrise "Different knots of Ropelove", Youssou N'Dour "Rokku mi rokka", Wolfpack Unleashed "Anthems Of Resistance", Robert Plant / Alison Krauss "Raising Sand", Sigur Ros"Hvarf-Heim"

Kuula / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2004-01-01

Heliplaatidest: Tori Amos "Tales Of A Librarian: A Tori Amos Collection", Madonna "Remixed & Revisited", No Doubt "The Singles 1992-2003", Basement Jaxx "Kish Kash", Erykah Badu "Worldwide Underground"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2003-01-01

Heliplaatidest: Marvin Gaye"What's Going On", Dynamite Vikings featuring Pierre Dorge "Vikingology", Pet Shop Boys "Disco 3", erinevad esitajad "We're a Happy Family: A Tribute to the Ramones", Ozzy Osbourne "Essential"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2002-01-01

Heliplaatidest Rinocerose "Music Kills Me". Supertramp "Slow Motion". Sneaker Pimps "Bloodsport". Gorillaz "G-Sides". Kukerpillid "Pojad on mul õige naksid". Timo Maas "Loud". Tomas Jirku "Immaterial". Tomas Jirku "Variants"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2008-01-01

Heliplaatidest: Lightspeed Champion "Falling Off the Lavender Bridge", Godsmack - "Good Times, Bad Times...Ten Years of Godsmack", Burnt Friedmann "First Night Forever", Steve Jansen "Slope", Vanessa Carlton "Heroes & Thieves", House of Games "Rise and Shine", Op:l Bastards "The Job"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2002-01-01

Heliplaatidest: Khia "Thug Misses", LHB "Tell 'em Who We Are", Oxide & Neutrino "2 Stepz Ahead", Golden Boy with Miss Kittin "Or", Slum Village "Trinity", Clipse "Lord Willin", DJ Jazzy Jeff "The Magnificent", Low "Trust"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2001-01-01

Heliplaatidest: Colourbox/M.A.R.R.S. "Best of Colourbox 1982-87". Saint Etienne "Smash The System - Singles and More". The Other People Place "Lifestyles of the Laptop Cafe". Supersilent "5". Eels "Souljacker". Lamb "What Sound". Incubus "Morning View". Staind "Break The Cycle". Puddle of Mudd "Come Clean". Godflesh "In All Languages"

Pop / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2003-01-01

Heliplaatidest: Swayzak "Dirty Dancing", De La Soul "Best Of", David Sylvian "Blemish", Evanescence "Fallen", Macy Gray "The Trouble With Being Myself", Audio Bullys "Ego War", Eesti Raadio laululapsed "Maasikad. Reinuvaderi ja Karuoti laulud"

Reversal of coagulopathy in critically ill patients with traumatic brain injury: recombinant factor VIIa is more cost-effective than plasma.

Science.gov (United States)

Stein, Deborah M; Dutton, Richard P; Kramer, Mary E; Scalea, Thomas M

2009-01-01

Traumatic brain injury (TBI) is the leading cause of death and disability after trauma. Coagulopathy is common in this patient population and requires rapid reversal to allow for safe neurosurgical intervention and prevent worsening of the primary injury. Typically reversal of coagulopathy is accomplished with the use of plasma. Recombinant factor VIIa (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark) has become increasingly used "off-label" in patients with neurosurgical emergencies to rapidly reverse coagulopathy. We hypothesized that the use of rFVIIa in this patient population would prove to be cost-effective as well as demonstrate clinical benefit. The trauma registry at the R Adams Cowley Shock Trauma Center was used to identify all coagulopatic trauma patients admitted between January 2002 and December 2007 with relatively isolated TBI (head Abbreviated Injury Scale score of >or=4). The medical records of patients were reviewed and demographics, injury-specific data, medications administered, laboratory values, blood product utilization, neurosurgical procedures, length of stay (LOS), discharge disposition, and outcome data were abstracted. Patients who received rFVIIa for reversal of coagulopathy were compared against those who did not receive rFVIIa. t Tests were used to compare differences between continuous variables, and chi2 analysis was used to compare categorical variables. A p value of percentage of patients with head Abbreviated Injury Scale score of 5 injuries, patients who underwent neurosurgical procedures and patients with preinjury warfarin use. There was no difference in total charges between these groups (mean US $63,403 in the conventionally treated group vs. $66,086). When patients who required admission to the intensive care unit were analyzed (n = 110, 50% received rFVIIa), total mean charges and costs were significantly lower in the group that received rFVIIa (mean US $108,900 vs. $77,907). Hospital LOS, days of mechanical

Factor VII and protein C are phosphatidic acid-binding proteins.

Science.gov (United States)

Tavoosi, Narjes; Smith, Stephanie A; Davis-Harrison, Rebecca L; Morrissey, James H

2013-08-20

Seven proteins in the human blood clotting cascade bind, via their GLA (γ-carboxyglutamate-rich) domains, to membranes containing exposed phosphatidylserine (PS), although with membrane binding affinities that vary by 3 orders of magnitude. Here we employed nanodiscs of defined phospholipid composition to quantify the phospholipid binding specificities of these seven clotting proteins. All bound preferentially to nanobilayers in which PS headgroups contained l-serine versus d-serine. Surprisingly, however, nanobilayers containing phosphatidic acid (PA) bound substantially more of two of these proteins, factor VIIa and activated protein C, than did equivalent bilayers containing PS. Consistent with this finding, liposomes containing PA supported higher proteolytic activity by factor VIIa and activated protein C toward their natural substrates (factors X and Va, respectively) than did PS-containing liposomes. Moreover, treating activated human platelets with phospholipase D enhanced the rates of factor X activation by factor VIIa in the presence of soluble tissue factor. We hypothesize that factor VII and protein C bind preferentially to the monoester phosphate of PA because of its accessibility and higher negative charge compared with the diester phosphates of most other phospholipids. We further found that phosphatidylinositol 4-phosphate, which contains a monoester phosphate attached to its myo-inositol headgroup, also supported enhanced enzymatic activity of factor VIIa and activated protein C. We conclude that factor VII and protein C bind preferentially to monoester phosphates, which may have implications for the function of these proteases in vivo.

Content and Form Anaysis of the Web Sites of University Libraries: A study on the Case in Turkey Üniversite Kütüphaleri Web Sitelerinin Biçim ve İçerik Analizi: Türkiye'deki Uygulamaya İlişkin Bir Araştırma

Directory of Open Access Journals (Sweden)

Mesut Kurulgan

2006-06-01

Full Text Available Internet is an important medium in the process of development of information and information technologies. University library web sites are used by many users to reach information. The speed, ease and efficiency of library web site usage contributes to users' satisfaction. This study compares library web sites of state universities to the foundation universities in terms of form and content. Evaluation criteria obtained through content analysis is measured by visiting each library Web site and measures are given as frequency distribution and percentage analysis. The study concludes that library web sites of state universities use the Internet opportunities more effectively than the library web sites of foundation universities. Dünyadaki bilgi miktarının giderek artması ve bilgi teknolojilerinin gelişmesi sürecinde Internet önemli bir mecra oluşturmaktadır. Üniversite kütüphanelerinin web siteleri birçok kullanıcının bilgiye ulaşma noktasındaki beklentilerini karşılamaktadır. Kullanıcıların kütüphane web sitelerinden kolay ve etkin olarak yararlanması kullanıcı tatminini etkilemektedir. Bu çalışmada, Türkiye'deki devlet ve vakıf üniversitelerinin kütüphanelerinin web sitelerinin özellikleri, biçim ve içerik açısından karşılaştırılmaktadır. Üniversite kütüphanelerine ait web sitelerinin her bir ayrı ayrı ziyaret edilmiş ve belirlenen bazı değerlendirme ölçütleri kullanılarak içerik analizi yöntemi ile incelenmiştir. Çalışmada devlet üniversitelerinin kütüphanelerinin web sitelerinin, vakıf üniversitelerinin kütüphanelerinin web sitelerine göre daha yetkin olduğu ve Internet olanaklarını daha iyi kullandıkları belirlenmiştir.

Real-Time 3D Sonar Modeling And Visualization

Science.gov (United States)

1998-06-01

looking back towards Manta sonar beam, Manta plus sonar from 1000m off track. 185 NUWC sponsor Erik Chaum Principal investigator Don Brutzman...USN Sonar Officer LT Kevin Byrne USN Intelligence Officer CPT Russell Storms USA Erik Chaum works in NUWC Code 22. He supervised the design and...McGhee, Bob, "The Phoenix Autonomous Underwater Vehicle," chapter 13, AI-BasedMobile Robots, editors David Kortenkamp, Pete Bonasso and Robin Murphy

Corrosion Behavior of Arc Weld and Friction Stir Weld in Al 6061-T6 Alloys

International Nuclear Information System (INIS)

Yoon, Byoung Hyun; Kim, Heung Ju; Chang, Woong Seong; Kweon, Young Gak

2006-01-01

For the evaluation of corrosion resistance of Al 6061-T6 Alloy, Tafel method and immersion test was performed with Friction Stir Weld(FSW) and Gas Metal Arc Weld(GMAW). The Tafel and immersion test results indicated that GMA weld was severely attacked compared with those of friction stir weld. It may be mainly due to the galvanic corrosion mechanism act on the GMA weld

Proceedings of the Frontiers of Retrovirology Conference 2016

OpenAIRE

Zurnic, Irena; H?tter, Sylvia; Lehmann, Ute; Stanke, Nicole; Reh, Juliane; Kern, Tobias; Lindel, Fabian; Gerresheim, Gesche; Hamann, Martin; M?llers, Erik; Lesbats, Paul; Cherepanov, Peter; Serrao, Erik; Engelman, Alan; Lindemann, Dirk

2016-01-01

Table of contents Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic, Sylvia H?tter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik M?llers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann O2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV...

Proceedings of the Frontiers of Retrovirology Conference 2016

OpenAIRE

Zurnic, Irena; Hütter, Sylvia; Lehmann, Ute; Stanke, Nicole; Reh, Juliane; Kern, Tobias; Lindel, Fabian; Gerresheim, Gesche; Hamann, Martin; Müllers, Erik; Lesbats, Paul; Cherepanov, Peter; Serrao, Erik; Engelman, Alan; Lindemann, Dirk

2016-01-01

Table of contents Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann O2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV...

Genetic characterisation of novel resistance alleles to stem rust and stripe rust in wheat-alien introgression lines

OpenAIRE

Rahmatov, Mahbubjon

2016-01-01

Bread wheat (Triticum aestivum L., 2n = 6x = 42, AABBDD) is one of the most important food crops world-wide, but is attacked by many diseases and pests that cause significant yield losses. Globally, stem rust (Sr) (Puccinia graminis f. sp. tritici Erikss & E. Henning), stripe rust (Yr) (Puccinia striiformis Westend. f. sp. tritici Eriks) and leaf rust (Lr) (Puccinia triticina Eriks) are a great threat to wheat production. The majority of the Sr, Yr and Lr resistance genes are already defeated...

Erratum

DEFF Research Database (Denmark)

Larsen, Erik Hviid; Amstrup, Jan

2016-01-01

The authors regret that there are errors in Figs. 10 and 111 of the article referenced above. In subsequent experimentation, the results of the original study generated by J. Amstrup (GenBank: AY02676) could not be reproduced. In the laboratory of E.H. Larsen, this was discovered by Svend Erik...... Westh Hansen, who subsequently cloned and verified a significant piece of the gene as listed in GenBank: AY02676[1.2] (submitted by Westh Hansen, S.E. and Hviid Larsen, E.). The wrong data has been rectified in this corrigendum by replacing the original Figs. 10 and 11 by the revised versions given......RNA clones were isolated that span 1400 bp of CFTR, including the R-domain and the first nucleotide binding domain, NBD1. The cloned DNA was assembled into a consensus sequence of CFTR coding regions (3-1394) and listed in GenBank with accession number AY02676[1.2] (authors: Svend Erik Westh Hansen and Erik...

Age-related changes in factor VII proteolysis in vivo.

Science.gov (United States)

Ofosu, F A; Craven, S; Dewar, L; Anvari, N; Andrew, M; Blajchman, M A

1996-08-01

Previous studies have reported that pre-operative plasmas of patients over the age of 40 years who developed post-operative deep vein thrombosis (DVT) had approximately twice the amount of proteolysed factor VII found in plasmas of patients in whom prophylaxis with heparin or low M(r) heparin was successful. These and other studies also reported higher concentrations of thrombin-antithrombin III in pre- and post-operative plasmas of patients who developed post-operative thrombosis than in plasmas of patients in whom prophylaxis was successful. Whether the extent of factor VII proteolysis seen in the patients who developed post-operative DVT is related to the severity of their disease or age is not known. This report investigated age-related changes in the concentrations of total factor VII protein, factor VII zymogen, factor VIIa, tissue factor pathway inhibitor, thrombin-antithrombin III, and prothrombin fragment 1 + 2 in normal plasmas and the relationships between these parameters. With the exception of thrombin-antithrombin III, statistically significant increases in the concentrations of these parameters with age were found. Additionally, the differences between the concentrations of total factor VII protein and factor VII zymogen, an index factor VII proteolysis in vivo, were statistically significant only for individuals over age 40. Using linear regression analysis, a significant correlation was found to exist between the concentrations of plasma factor VIIa and prothrombin fragment 1 + 2. Since factor VIIa-tissue factor probably initiates coagulation in vivo, we hypothesize that the elevated plasma factor VIIa (reflecting a less tightly regulated tissue factor activity and therefore increased thrombin production in vivo) accounts for the high risk for post-operative thrombosis seen in individuals over the age of 40.

El desarrollo psicosocial de Eric Erikson. El diagrama epigenético del adulto

OpenAIRE

Bordignon, Nelso Antonio

2005-01-01

This work shows a brief on the psychosocial development theory of Erik Erikson, and the epigenetic diagram of adults. It makes a brief of the content of each psychosocial stage and shows the diagram of adults, according to the VIII stages of the whole life cycle. El trabajo presenta una síntesis de la teoría del desarrollo psicosocial de Erik Erikson y el diagrama epigenético del adulto. Hace un resumen del contenido de cada estadío psicosocial y presenta el Diagram...

Monitoring corrosion and corrosion control of iron in HCl by non-ionic surfactants of the TRITON-X series - Part II. Temperature effect, activation energies and thermodynamics of adsorption

International Nuclear Information System (INIS)

Amin, Mohammed A.; Ahmed, M.A.; Arida, H.A.; Arslan, Taner; Saracoglu, Murat; Kandemirli, Fatma

2011-01-01

Research highlights: → TX-305 exhibits inhibiting properties for iron corrosion more than TX-165 and TX 100. → Inhibition efficiency increases with temperature, suggesting chemical adsorption. → The three tested surfactants act as mixed-type inhibitors with cathodic predominance. → Validation of corrosion rates measured by Tafel extrapolation method is confirmed. - Abstract: The inhibition characteristics of non-ionic surfactants of the TRITON-X series, namely TRITON-X-100 (TX-100), TRITON-X-165 (TX-165) and TRITON-X-305 (TX-305), on the corrosion of iron was studied in 1.0 M HCl solutions as a function of inhibitor concentration (0.005-0.075 g L -1 ) and solution temperature (278-338 K). Measurements were conducted based on Tafel extrapolation method. Electrochemical frequency modulation (EFM), a non-destructive corrosion measurement technique that can directly give values of corrosion current without prior knowledge of Tafel constants, is also presented. Experimental corrosion rates determined by the Tafel extrapolation method were compared with corrosion rates obtained by the EFM technique and an independent method of chemical analysis. The chemical method of confirmation of the corrosion rates involved determination of the dissolved cation, using ICP-AES (inductively coupled plasma atomic emission spectrometry). The aim was to confirm validation of corrosion rates measured by the Tafel extrapolation method. Results obtained showed that, in all cases, the inhibition efficiency increased with increase in temperature, suggesting that chemical adsorption occurs. The adsorptive behaviour of the three surfactants followed Temkin-type isotherm. The standard free energies of adsorption decreased with temperature, reflecting better inhibition performance. These findings confirm chemisorption of the tested inhibitors. Thermodynamic activation functions of the dissolution process were also calculated as a function of each inhibitor concentration. All the results

Standard electrode potential, Tafel equation, and the solvation thermodynamics.

Science.gov (United States)

Matyushov, Dmitry V

2009-06-21

Equilibrium in the electronic subsystem across the solution-metal interface is considered to connect the standard electrode potential to the statistics of localized electronic states in solution. We argue that a correct derivation of the Nernst equation for the electrode potential requires a careful separation of the relevant time scales. An equation for the standard metal potential is derived linking it to the thermodynamics of solvation. The Anderson-Newns model for electronic delocalization between the solution and the electrode is combined with a bilinear model of solute-solvent coupling introducing nonlinear solvation into the theory of heterogeneous electron transfer. We therefore are capable of addressing the question of how nonlinear solvation affects electrochemical observables. The transfer coefficient of electrode kinetics is shown to be equal to the derivative of the free energy, or generalized force, required to shift the unoccupied electronic level in the bulk. The transfer coefficient thus directly quantifies the extent of nonlinear solvation of the redox couple. The current model allows the transfer coefficient to deviate from the value of 0.5 of the linear solvation models at zero electrode overpotential. The electrode current curves become asymmetric in respect to the change in the sign of the electrode overpotential.

Korruptsiooni bioloogilised juured / Jaak Rebane

Index Scriptorium Estoniae

Rebane, Jaak

1999-01-01

Kuritarvitusele aitavad viia inimese teatud omadused, nagu egoism, piiratus, ahnus, jultumus, tarbimismentaliteet, tõusiklikkus. Korrumptantsaab varumistungi ajel ebaeetilisest käitumisest hoopis positiivse emotsiooni

Seitsmekesi majandustuultes / Erik Terk

Index Scriptorium Estoniae

Terk, Erik, 1952-

2016-01-01

Eesti majanduse seisu ja käekäigu võrdlemine teiste riigisotsialismist startinud ning ELi raames toimiva majandusega maadega. Visegrádi neliku (Tšehhi, Slovakkia, Ungari, Poola) ning Balti kolmiku (Eesti, Läti, Leedu) majanduse võrdlus

Mittesurmavad relvad / Erik Levoll

Index Scriptorium Estoniae

Levoll, Erik

2012-01-01

Mittesurmavad relvad (non-lethal weapon). Ülevaade nn humaansetest tulevikurelvadest: akustilised relvad (infrahelirelvad, ülivõimsad valjuhääldid, helikahurid), elektromagnetrelvad (elektromagnetpommid), psühhotroonsed relvad, laserrelvad

Insurance bankruptcy creates political storm

Index Scriptorium Estoniae

2005-01-01

Hoolimata peaminister Algirdas Brazauskase nõudmisest, keeldus Leedu kindlustusinspektsiooni juht Edvinas Vasilis-Vasiliauskas oma kohalt tagasi astumast, kuna soovib viia lõpule kindlustusseltsi Ingo Baltic pankrotiprotsessi

Electrochemical evaluation of electrocatalysts for fuel cell applications : a practical approach

Energy Technology Data Exchange (ETDEWEB)

Atwan, M.H. [General Motors R and D Technical Center, Warren, MI (United States); Gyenge, E.L. [British Columbia Univ., Vancouver, BC (Canada). Dept. of Chemical and Biological Engineering; Northwood, D.O. [Windsor Univ., ON (Canada). Dept. of Mechanical, Automotive and Materials Engineering

2010-07-01

Various electrochemical techniques were used to investigate supported nano-size electrocatalysts during the oxidation of a specific fuel for fuel cell applications. Cyclic voltammetry (CV) on static and dynamic rotating disc electrodes (RDE) and fuel cell station tests demonstrated that the most active catalyst showed the most negative oxidation peak potential. A Tafel equation indicated that a low anodic/cathodic overpotential was a clear indication of higher catalytic activity. The lower overpotential was achieved for a specific current load by ensuring a low Tafel slope and as high an exchange current density as possible. The RDE and fuel cell station tests showed that the best performance was recorded for electrocatalysts with the Tafel slope values and exchange current densities that gave rise to the lowest overpotential. The study demonstrated that RDE and CV can be used to reliably assess electrocatalysts prior to full fuel cell testing. 52 refs., 3 tabs., 6 figs.

Electrode kinetics of a water vapor electrolysis cell

Science.gov (United States)

Jacobs, G.

1974-01-01

The anodic electrochemical behavior of the water vapor electrolysis cell was investigated. A theoretical review of various aspects of cell overvoltage is presented with special emphasis on concentration overvoltage and activation overvoltage. Other sources of overvoltage are described. The experimental apparatus controlled and measured anode potential and cell current. Potentials between 1.10 and 2.60 V (vs NHE) and currents between 0.1 and 3000 mA were investigated. Different behavior was observed between the standard cell and the free electrolyte cell. The free electrolyte cell followed typical Tafel behavior (i.e. activation overvoltage) with Tafel slopes of about 0.15, and the exchange current densities of 10 to the minus 9th power A/sq cm, both in good agreement with literature values. The standard cell exhibitied this same Tafel behavior at lower current densities but deviated toward lower than expected current densities at higher potentials. This behavior and other results were examined to determine their origin.

Application of electrochemical frequency modulation for monitoring corrosion and corrosion inhibition of iron by some indole derivatives in molar hydrochloric acid

International Nuclear Information System (INIS)

Khaled, K.F.

2008-01-01

The corrosion inhibition effect of four indole derivatives, namely indole (IND), benzotriazole (BTA), benzothiazole (BSA) and benzoimidazole (BIA), have been used as possible corrosion inhibitors for pure iron in 1 M HCl. In this study, electrochemical frequency modulation, EFM was used as an effective method for corrosion rate determination in corrosion inhibition studies. By using EFM measurements, corrosion current density was determined without prior knowledge of Tafel slopes. Corrosion rates obtained using EFM, were compared to that obtained from other chemical and electrochemical techniques. The results obtained from EFM, EIS, Tafel and weight loss measurements were in good agreement. Tafel polarization measurements show that indole derivatives are cathodic-type inhibitors. Molecular simulation studies were applied to optimize the adsorption structures of indole derivatives. The inhibitor/iron/solvent interfaces were simulated and the adsorption energies of these inhibitors were calculated. Quantum chemical calculations have been performed and several quantum chemical indices were calculated and correlated with the corresponding inhibition efficiencies

A Budget Impact Model of Hemophilia Bypassing Agent Prophylaxis Relative to Recombinant Factor VIIa On-Demand.

Science.gov (United States)

Mehta, Darshan A; Oladapo, Abiola O; Epstein, Joshua D; Novack, Aaron R; Neufeld, Ellis J; Hay, Joel W

2016-02-01

Hemophilia patients use factor-clotting concentrates (factor VIII for hemophilia A and factor IX for hemophilia B) for improved blood clotting. These products are used to prevent or stop bleeding episodes. However, some hemophilia patients develop inhibitors (i.e., the patient's immune system develops antibodies against these factor concentrates). Hence, these patients do not respond well to the factor concentrates. A majority of hemophilia patients with inhibitors are managed on-demand with the following bypassing agents: recombinant factor VIIa (rFVIIa) and activated prothrombin complex concentrate (aPCC). The recently published U.S. registries Dosing Observational Study in Hemophilia (DOSE) and Hemostasis and Thrombosis Research Society (HTRS) reported higher rFVIIa on-demand use for bleed management than previously described. To estimate aPCC and rFVIIa prophylaxis costs relative to rFVIIa on-demand treatment cost based on rFVIIa doses reported in U.S. registries. A literature-based cost model was developed assuming a base case on-demand annual bleed rate (ABR) of 28.7 per inhibitor patient, which was taken from a randomized phase 3 clinical trial. The doses for rFVIIa on-demand were taken from the median dose per bleed reported by the DOSE and HTRS registries. Model inputs for aPCC and rFVIIa prophylaxis (i.e., dosing and efficacy) were derived from respective randomized clinical trials. Cost analysis was from the U.S. payer perspective, and only direct drug costs were considered. The drug cost was based on the Medicare Part B 2014 average sale price (ASP). Two-way sensitivity and threshold analyses were performed by simultaneously varying on-demand ABR, prophylaxis efficacy, and unit drug cost. In addition to studying relative costs associated with on-demand and prophylaxis treatments, relative cost per bleeding episode avoided were also calculated for aPCC and rFVIIa prophylaxis treatments. The prophylaxis efficacy reported in the trials were used to

Drug therapy for gastrointestinal and liver diseases

National Research Council Canada - National Science Library

Ballinger, Anne; Farthing, M. J. G. (Michael J. G.)

2001-01-01

... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Peptic ulcer disease Erik AJ Rauws, Guido NJ Tytgat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Emesis Gareth J Sanger, Paul LR Andrews...

Gaza võitmatu armaada / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2010-01-01

Katsest viia laevadega humanitaarabi Gaza sektorisse. Autor on arvamusel, et kui Vabaduse laevastik ongi saavutanud soovitu ja murdnud blokaadi, siis uus tasakaal pole julgeoleku mõttes sugugi kindlam

The Anxiety Disorder Clinic for Children and Adolescents (TADCCA) at Aarhus University in Denmark

DEFF Research Database (Denmark)

Thastum, Mikael

2013-01-01

for children with anxiety problems. The second case study is one of the total group of six families in which Erik was participating; as such it includes a summary of Erik's case in the context of the other five who participated. The group was conducted by a combination of a senior doctoral clinical...... psychologist and eight students. They were part of a training clinic, called The Anxiety Disorder Clinic for Children and Adolescents (TADCCA), in the Educational and Research Clinic of the Department of Psychology at Aarhus University in Aarhus, Denmark. This article describes the background and context...

Veemajandus saab jõudsalt areneda / Aare Lepaste

Index Scriptorium Estoniae

Lepaste, Aare, 1970-

2004-01-01

8. detsembril kirjutasid seitsme vee-ettevõtte esindajad, KIK-i juhataja ja keskkonnaminister alla Eesti suurimale keskkonnaprojektile. Projekti eesmärk on viia omavalitsuste veemajanduse infrastruktuur vastavusse EL-i direktiividega.

Keskerakond võitis Ida-Virus valimised mäekõrguselt / Erik Kalda, Erik Gamzejev

Index Scriptorium Estoniae

Kalda, Erik, 1969-

2007-01-01

Ilmunud ka: Severnoje Poberezhje, 6. märts 2007, lk. 1,3-4. Ida-Virumaalt pääses Riigikokku neli inimest Kesk- ja kaks Reformierakonnast. Lisa: Hääletamistulemused Ida-Virumaa valimisringkonnas. Vt. samas: Põrujad tunnistavad lüüasaamist

Iisraeli ühiskond on lõhenemas / Jüri Piirisild

Index Scriptorium Estoniae

Piirisild, Jüri

2004-01-01

Iisraeli sisepinged seoses juhtkonna plaaniga juudi asunikud Gaza sektorist välja viia ning aastakümneid kestnud konflikt palestiinlastega on mõjutanud nii riigi majandust kui usaldust peaminister Ariel Sharoni vastu

Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease

Directory of Open Access Journals (Sweden)

Christopher A. Sinkler

2017-01-01

Full Text Available Cytochrome c oxidase (COX is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen. COX consists of 14 subunits, three and eleven encoded, respectively, by the mitochondrial and nuclear DNA. Tissue- and condition-specific isoforms have only been reported for COX but not for the other oxidative phosphorylation complexes, suggesting a fundamental requirement to fine-tune and regulate the essentially irreversible reaction catalyzed by COX. This article briefly discusses the assembly of COX in mammals and then reviews the functions of the six nuclear-encoded COX subunits that are expressed as isoforms in specialized tissues including those of the liver, heart and skeletal muscle, lung, and testes: COX IV-1, COX IV-2, NDUFA4, NDUFA4L2, COX VIaL, COX VIaH, COX VIb-1, COX VIb-2, COX VIIaH, COX VIIaL, COX VIIaR, COX VIIIH/L, and COX VIII-3. We propose a model in which the isoforms mediate the interconnected regulation of COX by (1 adjusting basal enzyme activity to mitochondrial capacity of a given tissue; (2 allosteric regulation to adjust energy production to need; (3 altering proton pumping efficiency under certain conditions, contributing to thermogenesis; (4 providing a platform for tissue-specific signaling; (5 stabilizing the COX dimer; and (6 modulating supercomplex formation.

77 FR 61753 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Science.gov (United States)

2012-10-11

.... 20121302 G Arrow Electronics. Inc.; John F. Baker (Micro Electronics, Inc.); Arrow Electronics, Inc. 20121303 G Wind Point Partners L.P.; Mistral Equity Partners, LP; Wind Point Partners VII-A, L.P. 20121307...

Lennufirmad ägavad nafta hinna surve all / Tõnis Arnover

Index Scriptorium Estoniae

Arnover, Tõnis, 1952-

2004-01-01

Nafta kõrge hind ähvardab palju kütust tarbivad lennukompaniid kahjumisse viia kuna tiheda konkurentsi tingimustes piletihindu tõsta ei soovita. Diagramm: Nafta hind tänavu kerkinud üle kolmandiku

Aeg panustada nafta hinna langusele / Tarvo Vaarmets

Index Scriptorium Estoniae

Vaarmets, Tarvo

2008-01-01

Autor analüüsib maailma naftatootmist ning leiab, et vähenev naftanõudlus võib viia nafta hinna langusele. Vt. samas: Kuidas nafta hinna langusest kasu lõigata?; Tabel: Naftaturg; Võrdlusandmed

Laurentiuse kirik päästab Saueri oreli osi niiskuse käest / Andres Sepp ; kommenteerinud Anti Toplaan

Index Scriptorium Estoniae

Sepp, Andres, 1976-

2009-01-01

Kuressaare Laurentiuse kiriku kogudus otsib võimalusi viia 1881. a. Wilhelm Saueri firmas valminud vanima Eestis säilinud oreli puidust ja metallist osad kuivemasse kohta. Praegu seisavad need kiriku garaažis

Cathodic over-potential and hydrogen partial pressure coupling in hydrogen evolution reaction of marine steel under hydrostatic pressure

International Nuclear Information System (INIS)

Xiong, X.L.; Zhou, Q.J.; Li, J.X.; Volinsky, Alex A.; Su, Y.J.

2017-01-01

Highlights: •Hydrostatic pressure increases the Volmer and the Heyrovsky reactions rates. •Hydrostatic pressure decreases the Tafel reaction rate. •Hydrogen adsorption conditions change with pressure under −1.2 and −1.3 V SSE . •Under −1.2 and −1.3 V SSE , the Heyrovsky reaction dominates the hydrogen recombination. •Under −1.0 and −1.1 V SSE , the Tafel reaction dominates the hydrogen recombination. -- Abstract: A new electrochemical impedance spectroscopy (EIS) model, which considers both the Tafel recombination and the Heyrovsky reaction under permeable boundary conditions, was developed to characterize the kinetic parameters of the hydrogen evolution reaction (HER) under hydrostatic pressure. The effect of the hydrostatic pressure on the kinetic parameters of the HER and the permeation of A514 steel in alkaline solution were measured using potentiodynamic polarization, the Devanathan cell hydrogen permeation, and EIS. The hydrostatic pressure accelerates the Volmer reaction and inhibits the Tafel recombination, which increases the number of adsorbed hydrogen atoms. On the other hand, the pressure accelerates the Heyrovsky reaction, which decreases the amount of adsorbed hydrogen atoms. At 10 to 40 MPa hydrostatic pressure within the −1.0 to −1.1 V SSE cathodic potential region, the HER is controlled by hydrogen partial pressure, and hydrogen adsorption is the Langmuir type. Within the −1.2 to −1.3 V SSE cathodic potential region, the HER is controlled by the potential, and hydrogen adsorption gradually transfers from the Langmuir type to the Temkin type with increasing hydrostatic pressure.

Electrochemical water splitting using nano-zeolite Y supported tungsten oxide electrocatalysts

Science.gov (United States)

Anis, Shaheen Fatima; Hashaikeh, Raed

2018-02-01

Zeolites are often used as supports for metals and metal oxides because of their well-defined microporous structure and high surface area. In this study, nano-zeolite Y (50-150 nm range) and micro-zeolite Y (500-800 nm range) were loaded with WO3, by impregnating the zeolite support with ammonium metatungstate and thermally decomposing the salt thereafter. Two different loadings of WO3 were studied, 3 wt.% and 5 wt.% with respect to the overall catalyst. The prepared catalysts were characterized for their morphology, structure, and surface areas through scanning electron microscope (SEM), XRD, and BET. They were further compared for their electrocatalytic activity for hydrogen evolution reaction (HER) in 0.5 M H2SO4. On comparing the bare micro-zeolite particles with the nano-form, the nano-zeolite Y showed higher currents with comparable overpotentials and lower Tafel slope of 62.36 mV/dec. WO3 loading brought about a change in the electrocatalytic properties of the catalyst. The overpotentials and Tafel slopes were observed to decrease with zeolite-3 wt.% WO3. The smallest overpotential of 60 mV and Tafel slope of 31.9 mV/dec was registered for nano-zeolite with 3 wt.% WO3, while the micro-zeolite gave an overpotential of 370 mV and a Tafel slope of 98.1 mV/dec. It was concluded that even with the same metal oxide loading, nano-zeolite showed superior performance, which is attributed to its size and hence easier escape of hydrogen bubbles from the catalyst.

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

Directory of Open Access Journals (Sweden)

Manash S Chatterjee

2010-09-01

Full Text Available Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF, human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa will generate thrombin after an initiation time (T(i of 1 to 2 hours (depending on donor, while activation of platelets with the GPVI-activator convulxin reduces T(i to ∼20 minutes. Since current kinetic models fail to generate thrombin in the absence of added TF, we implemented a Platelet-Plasma ODE model accounting for: the Hockin-Mann protease reaction network, thrombin-dependent display of platelet phosphatidylserine, VIIa function on activated platelets, XIIa and XIa generation and function, competitive thrombin substrates (fluorogenic detector and fibrinogen, and thrombin consumption during fibrin polymerization. The kinetic model consisting of 76 ordinary differential equations (76 species, 57 reactions, 105 kinetic parameters predicted the clotting of resting and convulxin-activated human blood as well as predicted T(i of human blood under 50 different initial conditions that titrated increasing levels of TF, Xa, Va, XIa, IXa, and VIIa. Experiments with combined anti-XI and anti-XII antibodies prevented thrombin production, demonstrating that a leak of XIIa past saturating amounts of CTI (and not "blood-borne TF" alone was responsible for in vitro initiation without added TF. Clotting was not blocked by antibodies used individually against TF, VII/VIIa, P-selectin, GPIb, protein disulfide isomerase, cathepsin G, nor blocked by the ribosome inhibitor puromycin, the Clk1 kinase inhibitor Tg003, or inhibited VIIa (VIIai. This is the first model to predict the observed behavior of CTI-treated human blood, either resting or stimulated with platelet activators. CTI-treated human blood will clot in vitro due to the combined activity of XIIa and XIa, a process enhanced by platelet activators and which proceeds

Savisaar : palk nelja aasta pärast 25 000 krooni / Kadi Heinsalu

Index Scriptorium Estoniae

Heinsalu, Kadi, 1966-

2006-01-01

Ilmunud ka: Delovõje Vedomosti 20. sept. lk. 6. Keskerakonna eesmärgiks on viia keskmine palk Eestis järgmise nelja aastaga 25 000 kroonini - Euroopa Liidu keskmisele tasemele. Diagramm: Palk avalikus sektoris

Las pank tuleb kiiresti kliendi juurde / Vallo Toomet

Index Scriptorium Estoniae

Toomet, Vallo, 1960-

2005-01-01

Autor on seisukohal, et pank võiks ise otsida klienti, kellele teha laenupakkumine, ning selgitab, kuidas seda ideed ellu viia. Sama süsteem võiks kehtida ka innovatsioonis, riskiprojektide puhul ja ettevõtluses

WW instituudi direktor Christopher Flavin : Kyoto protokoll viiakse ellu Bushita / Christopher Flavin ; interv. Tarmo Virki

Index Scriptorium Estoniae

Flavin, Christopher

2002-01-01

World Watch Instituudi direktor leiab, et maailm vajaks globaalset keskkonnaorganisatsiooni, mis tasakaalustaks Maailma Kaubandusorganisatsiooni mõju. Euroopa Liit ja Jaapan suudavad Kyoto protokolli ratifitseerimise ellu viia ka ilma USA-ta. Lisa: Tuumaenergia pole lahendus

Omavalitsused küsivad kohustuste täitmiseks riigilt raha juurde / Harda Roosna

Index Scriptorium Estoniae

Roosna, Harda, 1956-

2005-01-01

Läbirääkimistel valitsustega taotlevad omavalitsusliidud, Eesti Maaomavalitsuste liit (EMOL) ja Eesti Linnade liit (ELL), riigilt tulevaseks riigieelarve planeerimisperioodiks (2006-2009) kohalike omavalitsuste tulude kasvu, et viia tulubaas vastavusse omavalitsustele pandud kohustustega

THE APPLICATION OF RECIPROCAL TEACHING METHOD FOR IMPROVING THE UNDERSTANDING OF MATHEMATICS CONCEPT OF 7TH GRADE STUDENTS SMP NEGERI 2 DEPOK.

Directory of Open Access Journals (Sweden)

Tatag Bagus Argikas

2016-10-01

Full Text Available This research aims to: (1 describe the implementation of learning mathematics with Reciprocal Teaching methods that is for improving the concept of learning understanding mathematic in class VIIA SMP Negeri 2 Depok. (2 Knowing the increased understanding of student learning in class VIIA SMP Negeri 2 Depok use Reciprocal Teaching methods. This research constitutes an action in class that is according along the teacher. The data of research was collated by sheet observations and each evaluation of cycles. That is done in two cycles. The first was retrieved the average value of student learning achievement of 70.96%. The second was retrieved achievement of 90.32%. Thus this learning model can increase student learning understanding.   Key word: The understanding of Mathematical Concept, Reciprocal Teaching Method.

Börs nutab taga Eesti Energia loobumist / Jaana Pikalev ; kommenteerinud Jürgen Ligi, Sandor Liive

Index Scriptorium Estoniae

Pikalev, Jaana

2010-01-01

SEB privaatpanganduse osakonna strateeg Peeter Koppel, LHV Panga analüütik Sten Pisang, investor Stefan Andresson avaldavad arvamust seoses otsusega Eesti Energia veel mitte börsile viia. Majandus- ja kommunikatsiooniminister Juhan Partsi arvamus

Vesi peale! Ikka ja jälle Tallinna sadamaala kujundamisest / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2007-01-01

Tallinna sadamaala erinevatest planeeringutest ning arhitektuurikonkurssidest (Irina Raud, Veronika Valk, Villem Tomiste, Jan Verwijnen, Indrek Pottisep, Lembit Tork, Erik Konze, Taylor&Chapman). Näiteid Euroopast

Tere tulemast, Suncor?! / Erik Puura

Index Scriptorium Estoniae

Puura, Erik, 1964-

2000-01-01

Eesti Põlevkivisse investeerida sooviva Kanada tööstusgigandi Suncor Energy vastu protesteerib maailma juhtiv keskkonnakaitseorganisatsioon Greenpeace. Suncor Energy põlevkivi töötlemise projekt Austraalias. Tabel: Põlevkivi tarbimine, õlisaak ja CO₂ lisakogus Austraalias ning Eestis. 2007. ja 2010.a.

Investeeringuid naftatootmisesse napib / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2008-01-01

Rahvusvahelise Energeetikaagentuuri IEA prognoosi kohaselt katab nafta ka veel 2030. aastal suurema osa energiatarbest - umbes 40%, kütuste hinnatase jääb piisavalt kõrgeks, mistõttu energiafirmadel tasuks investeerida uutesse leiukohtadesse. Rahvusvahelise Valuutafondi ökonomisti Kevin Chengi ja investeerimispankuri Matthew Simmonsi hinnangud maailma naftavarudele. Lisa: Võidujooks nafta pärast

Erakonnad kombineerivad valimisnimekirju / Erik Gamzejev

Index Scriptorium Estoniae

Gamzejev, Erik, 1967-

2006-01-01

Ilmunud ka: Severnoje Poberezhje 5. okt. lk. 1,3. Suuremad erakonnad on praeguseks Ida-Virus suuremalt jaolt välja valinud kandidaadid, kes hakkavad parlamendivalimistel hääli koguma. Tabelid: Häälte jagunemine erakondadel vahel 2003. aasta riigikogu valimistel; Suuremad häältekogujad Ida-Virus 2003. a. riigikogu valimistel

Mitte ainult ristirahvale / Erik Konze

Index Scriptorium Estoniae

Konze, Erik

2009-01-01

Kaasaegse arhitektuuriga puukirikutest. Soomes Turus asuvast Püha Henriku kirikust (arhitektid Matti Sanaksenaho, Pirjo Sanaksenaho, Enrico Garbin). Austrias Andelsbuchis asuvast kabelist (arhitekt Andreas Cukrowicz). Šveitsis St. Loupi külas asuvast kabelist (arhitekt Danilo Mondada)

Palju alusetuid lubadusi / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

1999-01-01

Heliplaatidest : Stina Nordenstam : People are strange ; Mariah Carey : 1'S ; Muusika filmist ja filmist inspireeritud muusika : Psycho ; Erinevad gershwinistid : Red Hot + Rhapsody ; Jennifer Rush : Classics

Põlevkivist saabki nafta / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2015-01-01

Julia Krassulina doktortööst Upgrading of liquid products from Estonian kukersite oil shale by catalytic hydrogenation = Kukersiitpõlevkivi vedelproduktide vääristamine katalüütilise hüdrogeenimise meetodil

Uuenenud otsustuskogu : senat / Hille Erik

Index Scriptorium Estoniae

Erik, Hille

2005-01-01

12. septembril kogunes esimest korda TLÜ kollegiaalne otsustuskogu - senat: M. Heidmets, H. Mattisen, P. Normak, M. Lepik, M. Talsi, S. Liiv, P. Reiska, K. Port, E. Rüütel, A. Kivinukk, A. Pulver, R. Raud, E. Eisenschmidt, K. Karron, H. Šein, P. Raudkivi, A. Kollist, K. Katus, K. Loogma, R. Vetik, J.-M. Punning, M. Ehala, P. Tammela, T. Tõnise, L. Läänemets, L. Saareväli, A. King

Ingliskeelne eesti luule ja glokaalsuse keskenduvad keerud / Lauri Pilter

Index Scriptorium Estoniae

Pilter, Lauri, 1971-

2010-01-01

Inglise keele rollist eesti luuleteadvuses üldiselt, Bernard Kangro kogust "Earthbound" (1951) kui esimesest ingliskeelsest eesti luuletaja valikkogust ning võimalikest järeldustest, milleni võiks viia metafooride võrdlev uurimine eesti ja inglise luules

Üks küsimus

Index Scriptorium Estoniae

2003-01-01

Euroopa Komisjoni laienemisvoliniku Günther Verheugeni eestkõneleja Jean-Christophe Filori vastab küsimusele, milleni võivad viia valitsuskriisist tulenevad häired Riigikogu töös EL-iga liitumiseks vajalike seaduste vastuvõtmisel

Eesti üldhariduse finantsreformi olemus ja probleemid / Janno Reiljan, Ele Reiljan

Index Scriptorium Estoniae

Reiljan, Janno, 1951-2018

2005-01-01

Läbiviidav reform võib täiendavate investeerimisvahendite eraldamisest hoolimata kohalikele omavalitsustele pandavate pikaajaliste võlakohustuste ja õpikulude kaasrahastamise kohustuse koosmõjul üldhariduse koolivõrgu regionaalse tasakaalustamise asemel senisest enam tasakaalust välja viia

Investor wants listing for Estonian Railway, state officials balk at prospect

Index Scriptorium Estoniae

2004-01-01

Eesti Raudtee suuromanik Baltic Rail Service tahab ettevõtte 2005. aasta keskpaigaks börsile viia. Riik, mis on firma vähemusaktsionär, pole plaaniga nõus, kuna BRS-il on täitmata investeerimiskohustused

Üürilepingu erakorraline ülesütlemine üürniku makseviivituse tõttu / Kaidi Urgas, Karin Sein

Index Scriptorium Estoniae

Urgas, Kaidi, 1989-

2013-01-01

Võlaõigusseaduse § 316 kohaldamise teoreetilistest alustest ja rakendamise praktikast Eesti kohtutes ning seaduse ajakohastamise vajadusest, et poolte õigused ja kohustused paremini tasakaalu viia. Üürileandja ülesütlemisõigus Šveitsi ja Saksa õiguses

Pärleid vanapaberi hulgast : kohtumisi inimeste ja vanaraamatuga / Uno Schultz

Index Scriptorium Estoniae

Schultz, Uno, 1956-

2010-01-01

Bibliofiil Uno Schultzi vanaraamatute kogu kujunemisest ning inimestest, kellega haruldaste raamatute leidmisel kohtutud, sh Kyra Robertist, Voldemar Millerist, Trivimi Vellistest, Oskar Kuningast, Helene Kulpast, Erik Tederist jt.

The importance of residues 195-206 of human blood clotting factor VII in the interaction of factor VII with tissue factor

International Nuclear Information System (INIS)

Wildgoose, P.; Kisiel, W.; Kazim, A.L.

1990-01-01

Previous studies indicated that human and bovine factor VII exhibit 71% amino acid sequence identity. In the present study, competition binding experiments revealed that the interaction of human factor VII with cell-surface human tissue factor was not inhibited by 100-fold molar excess of bovine factor VII. This finding indicated that bovine and human factor VII are not structurally homologous in the region(s) where human factor VII interacts with human tissue factor. On this premise, the authors synthesized three peptides corresponding to regions of human factor VII that exhibited marked structural dissimilarity to bovine factor VII; these regions of dissimilarity included residues 195-206, 263-274, and 314-326. Peptide 195-206 inhibited the interaction of factor VII with cell-surface tissue factor and the activation of factor X by a complex of factor VIIa and tissue factor half-maximally at concentrations of 1-2 mM. A structurally rearranged form of peptide 195-206 containing an aspartimide residue inhibited these reactions half-maximally at concentrations of 250-300 μM. In contrast, neither peptide 263-274 nor peptide 314-326, at 2 mM concentration, significantly affected either factor VIIa interaction with tissue factor or factor VIIa-mediated activation of factor X. The data provide presumptive evidence that residues 195-206 of human factor VII are involved in the interaction of human factor VII with the extracellular domain of human tissue factor apoprotein

Piirivalve saab 147 miljoni eest uhke helikopteri / Sigrid Laev

Index Scriptorium Estoniae

Laev, Sigrid

2005-01-01

Eesti piirivalve saab helikopteri Agusta Bell, kopteri soetamine täidab Schnegen Facility programmi eesmärki, mille kohaselt tuleb EL-i välispiiride valve viia vastavusse Schengeni õigusruumi nõuetega. Raha ostmiseks annab abiprogramm Schengen Facility

Over my dead body / Martin Kala

Index Scriptorium Estoniae

Kala, Martin, 1977-

2004-01-01

Arutlus Türgi võimalikust liitumisest Euroopa Liiduga. Autori hinnangul on Türgi tõestanud oma suutlikkust viia läbi järjepidevaid reforme ja Euroopasse sobivad kõik riigid, mis suudavad tõestada oma demokraatlikku elukorraldust

Ettevaatust, kaitsepolitsei! / Roy Strider

Index Scriptorium Estoniae

Strider, Roy, 1974-

2007-01-01

Ajendatuna anarhistliku liikumise PunaMust meeleavalduse jälgimisest end ajakirjanikuks nimetanud kaitsepolitsei töötaja poolt kirjutab autor kaitsepolitsei mõttetust nuhkimisest oma kodanike järele, mis võib viia jälgimisühiskonnani

Kuidas puutuvad ring, kolmnurk ja ruut lillepeenrasse? / Ülle Kikas, Terje Hõim

Index Scriptorium Estoniae

Kikas, Ülle, 1949-

2016-01-01

2012. aastal alustas haridus- ja teadusministeerium koostöös Tartu Ülikooli ja tarkvara tootva Wolframi konsortsiumiga arvutipõhise statistika arendusprojekti, et viia statistika õpetamine koolides vastavusse tänapäeva võimaluste ja nõudmistega

Aeroflot tahab ka ise Moskvast Tallinna lennata / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2011-01-01

Aeroflot kavatseb suurendada oma rahvusvaheliste reiside hulka umbes veerandi võrra, uute sihtkohtade seas on infoportaali ATO.ru andmeil ka Tallinn. Tallinna lennujaama juhatuse liikme Erik Sakkovi kommentaare

Arabella, küberröövli tütar / Märt Milter

Index Scriptorium Estoniae

Milter, Märt

2005-01-01

Filmipiraatlus internetis : filmid enne esilinastust saadaval. Kuidas see toimib USA-s ja meil, mis ette võtta? Lisatud kommentaarid Business Software Alliance'i Eesti tegevuse koordinaatorilt Erik Mandrelt

Investor kardab ebakindlust / Aigar Ojaots

Index Scriptorium Estoniae

Ojaots, Aigar, 1974-

2007-01-01

ÜRO eriraportööri Jean Ziegleri avaldus kehtestada biokütuse kasutamisele viieks aastaks moratoorium võib viia olukorrani, kus keegi ei julge investeerida uutesse tehnoloogiatesse, kuna 5 aasta pärast võidakse taas meelt muuta

Vertikal bez granits / Svetlana Ragrina

Index Scriptorium Estoniae

Ragrina, Svetlana

2004-01-01

Moskva elab sõjaaja reaalsuses, terroriaktid ja terrorismioht võimaldavad võimuorganitel sisse viia kodanike kaitseks täiendavaid vabaduste ning õiguste piiranguid. Venemaa president Vladimir Putin tutvustas valitsusele, föderatsiooni subjektidele ja rahvale kavandatavaid muudatusi riigi juhtimises

Puustusmaa film jõudis esilinastuspäeval internetti / Dannar Leitmaa

Index Scriptorium Estoniae

Leitmaa, Dannar, 1982-

2008-01-01

Eesti autoriõiguste kaitseorganisatsiooni direktor Erik Mandre internetipiraatlusest ebaseadusliku filmide allalaadimise näol. A. Puustusmaa "18-14" levis internetis Elioni ftp-serverist juba Eesti esilinastuse päeval

Linnahalli renoveerimine venib veel vähemalt aasta / Tuuli Aug

Index Scriptorium Estoniae

Aug, Tuuli

2010-01-01

Tallinna linn ja USA firma Tallinn Entertainment LLC otsustasid Tallinna Linnahalli renoveerimiseks ja seda ümbritsevate kinnistute hoonestamiseks luua ühisettevõtte, mille asutamine ja hoonestusõiguse seadmine loodetakse lõpule viia jaanuaris 2011. Detailplaneeringust ja renoveerimisprojekti koostamisest, ühisfirma ehitusplaanist

Gordon Brown lubab valijal riigieelarvet ümber teha / Siim Trumm

Index Scriptorium Estoniae

Trumm, Siim

2007-01-01

Peaminister Gordon Brown kavandab mitmeid reforme, et viia riigivõim rahvale lähemale. Inglismaa kümne piirkonna inimestele antakse võimalus otsustada rahvahääletuse kaudu kohaliku eelarve jaotamise üle. Lisa: Browni ja leiboristide toetus kasvab

Tere tulemast uude sõtta / Jüri Pino

Index Scriptorium Estoniae

Pino, Jüri, 1970-

2011-01-01

14. aprillil toimunud NATO välisministrite kohtumisel viitas USA riigisekretär Hillary Clinton võimalusele, et Liibüasse tuleb ka maaväed sisse viia. Autor leiab, et see tähendab ka Eestile uue sõja algust

Birma takistab välisabi jagamist / Hendrik Vosman

Index Scriptorium Estoniae

Vosman, Hendrik

2008-01-01

Birma sõjaväediktatuur võtab küll tsüklon Nargise põhjustatud looduskatastroofi tõttu välisabi vastu, kuid keelab abiandjatel seda hädalistele kohale viia. Lisa: Ohvrite arv. Vt. samas: Referendum toimus katastroofist hoolimata

Jiri Shibori konstruktivistlik kujundimaailm / Eilve Manglus

Index Scriptorium Estoniae

Manglus, Eilve, 1977-

2004-01-01

Metallide tehnoloogiat õppinud Jiri Shibori näitus "Ehtekunsti ja skulptuuri vahel" Deco galeriis kuni 10. IV. Personaalnäitus toimub EKA ehte- ja sepakunsti osakonna kutsel, et viia läbi külmkinnituslike konstruktsioonidega metallitöö workshop

Berhard Schmidt - realiteet müütide vastu / Ülo Tonts

Index Scriptorium Estoniae

Tonts, Ülo, 1931-2016

1996-01-01

Arvustus: Optical illusions. The life story of Bernhard Schmidt the great stellar optician of the twentieth century by Erik Schmidt. Estonian Academy Publishers, 1995. Ka samast teemast Jaan Krossi 'Vastutuulelaevas'

Raamatulett / Jaanus Tamm

Index Scriptorium Estoniae

Tamm, Jaanus

1996-01-01

Hõkansson, Jan. Isa purjetab; Swarthout, Glendon. Õnnista loomi ja lapsi; Huxley, Aldous. Nood koltunud lehed; Hesse, Hermann. Narziss ja Goldmund; Olsen, Lars-Erik. Puutumata maa; Tamm, Jaanus. Öö

Ajaleheturul on 70% allahindlus igapäevane / Eda-Liis Kann

Index Scriptorium Estoniae

Kann, Eda-Liis, 1979-

2004-01-01

Selle asemel, et ametlikult reklaamihinda langetada pakuvad ajalehed reklaamiandjatele ülisuuri soodustusi. Kommenteerivad Enn Parel, Aavo Kokk, Andrus Vaher, Priit Leito, Erik Roose, Ruta Kallaspoolik, Toomas Tiivel, Lauri-Hillar Talve

Vidyasagar, Dr Mathukumalli

Indian Academy of Sciences (India)

Elected: 1992 Section: Engineering & Technology ... Address: Cecil & Ida Green Chair of Systems Biology Science, Erik Jonsson School of Engineering & Computer Science, The University of Texas at Dallas, ... Upcoming Refresher Courses.

Kunstitarbimisorgia kunstlikult põhjamaises suvitusrajoonis / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

2004-01-01

Jaan Toomiku ja Paul Rodgersi organiseeritud tegevuskunsti festivalist "Viinistu 2004", kavas performance'id, installatsioonid, video, näitused. Pikemalt Steven Coheni, Elu, Neeme Külma, Minna Hindi, Erik Alalooga esinemisest

Läbipaistva saunaga Austraalias / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2010-01-01

Kunstnike grupp Art Container osales Brisbane'i teatrifestivalil (4.-25. sept. 2010) interaktiivse etenduse ja saunainstallatsiooniga "Kümblejad" (autorid Tanel Saar, Erik Alalooga, Sandra Jõgeva, Janno Bergmann, Hans-Gunter Lock)

Pühendusega isadele - Baker Street

Index Scriptorium Estoniae

2009-01-01

Üritusest 7. novembril Kuressaares Arensburg lounge-restoranis Muusa toimuvast isadepäevahõngulisest üritusest, esinevad Virgo Veldi & Band kavaga "Baker Street", erikülalisena Villu Veski. Saksofonistist Virgo Veldist

Tantsupäev toob priimad tantsijad / Stuart Sweeney

Index Scriptorium Estoniae

Sweeney, Stuart

2006-01-01

Rahvusvahelisel tantsupäeval 29. aprillil esinevad Vanemuises nimekad Euroopa tantsijad. Neist tuntumad on Londoni Kuningliku balleti priimabaleriin Tamara Rojo ja Rootsi Kuningliku Balleti koosseisus tantsiv Jan-Erik Wikström

Korterelamud Supilinnas = Apartment buildings in Supilinn / Kaido Kepp ; intervjueerinud Margit Mutso

Index Scriptorium Estoniae

Kepp, Kaido

2012-01-01

Tartus Meloni t. 28, Oa t. 31 ja 33 asuvate korterelamute arhitektuursest lahendusest. Kergplokkidest elamud on kaetud laudvoodriga, fassaadi keskmine osa on kaetud dekooriga. Arhitektid Kaido Kepp ja Erik Mutso (Arhitektuuriklubi)

Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.

NARCIS (Netherlands)

Ree, M.A. van de; Maat, M.P. de; Kluft, C.; Meinders, A.E.; Princen, H.M.; Huisman, M.V.

2003-01-01

BACKGROUND: Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1). OBJECTIVES: To evaluate the effect of aggressive

Orwelli nimekiri / Mihhail Lotman

Index Scriptorium Estoniae

Lotman, Mihhail, 1952-

2014-01-01

Aleksandr II-le sooritatud atentaadikatsest 1866. aastal. Heinrich Bölli teosest "Katharina Blumi kaotatud au, ehk, Kuidas vägivald võib tekkida ja kuhu välja viia". Senaator Joseph McCarthy'st. George Orwelli poolt Informatsiooniuuringute osakonnale esitatud nimekirjast. Orwelli eluloost

Soomlased teevad silma Eesti toidutööstusele / Silva Männik

Index Scriptorium Estoniae

Männik, Silva, 1974-

2004-01-01

EL-iga liitumise eel plaanivad mitmed Soome ettevõtjad investeerida Eesti toiduainetööstustesse ja viia Eesti tooted Soome turule. Diagrammid: Soomlane sööb üha enam Eesti toitu. Kommenteerivad Joakim Helenius ja Ain Hanschmidt. Lisa: Näiteid soomlaste tehingutest

RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice

Czech Academy of Sciences Publication Activity Database

Jahanban-Esfahlan, R.; Seidi, K.; Monhemi, H.; Adli, A.D.F.; Minofar, Babak; Zare, P.; Farajzadeh, D.; Farajnia, S.; Behzadi, R.; Abbasi, M.M.; Zarghami, N.; Javaheri, T.

2017-01-01

Roč. 7, AUG 15 (2017), s. 1-14, č. článku 8126. ISSN 2045-2322 Institutional support: RVO:61388971 Keywords : TISSUE-FACTOR * FACTOR-VIIA * STAPHYLOCOAGULASE Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 4.259, year: 2016

Vene tagapõhjaga organisatsiooni väärtuste uurimisplaan (Kreenholmi Valduse AS näitel) / Anne Reino

Index Scriptorium Estoniae

Reino, Anne, 1972-

2004-01-01

Uurimus Kreenholmi Valdus AS-i väärtustest on plaanis läbi viia 2004. aasta jooksul ning see on üheks osaks suuremast uuringust, mille eesmärgiks on Eesti organisatsioonide väärtuste võrdlev analüüs

PKN Orlen takes share in Mazeikiu Nafta

Index Scriptorium Estoniae

2007-01-01

Poola naftatöötlejatele kuulub peale ostupakkumist väikeaktsionäridele 89% Mazeikiu Nafta aktsiatest, mis võib viia ettevõtte väljaviimiseni börsilt. Jukose väitel pole PKN Orleni raha aktsiate eest endise omanikuni jõudnud

Rein Einasto : Eestis valitud ameerikalik valitsemise tee viib meid katastroofini / Rein Einasto ; interv. Kristi Leppik

Index Scriptorium Estoniae

Einasto, Rein, 1934-

2008-01-01

Kodanikuühiskonna edendamisest Eestis. Aasta missiooniinimese kandidaadiks esitatud professor Rein Einasto arvates päästaks meid avar mõtlemine, et viia inimkond tervikuna teisele teele. Praegune vaba turumajandus on pillamisele, raiskamisele ja kulutamisele üles ehitatud ummiktee. Lisa: Rein Einasto

Raamatulett / Jaanus Tamm

Index Scriptorium Estoniae

Tamm, Jaanus

1996-01-01

Põder, Rein. Armastuse hääl; Schmidt, Erik. Pagana eestlane!; Lina, Jüri. Skorpioni märgi all; Nesser, Hõkan, Tagasitulek; Fallada, Hans. Tookord meil isakodus; Fitzgerald, Francis Scott. Suur Gatsby

Dirc van Delfts Tafel van den Kersten Ghelove en de stervensliteratuur

DEFF Research Database (Denmark)

Robbe, Joost Roger

2015-01-01

treatise, Dirc van Delft presents a veritable ars moriendi which provides practical guidance for the dying and those attending them. The treatise culminates in a vivid drama in which the soul, being subject to three temptations of the devil, can benefit from the protection of its guardian angel as well...

[Diffraction gratings used in x-ray spectroscopy]: Final report

International Nuclear Information System (INIS)

Smith, H.I.

1988-01-01

This subcontract was initiated in order to facilitate the development at MIT of technologies for fabricating the very fine diffraction grating required in x-ray spectroscopy at Lawrence Livermore Laboratory (LLL). These gratings are generally gold transmission gratings with spatial periods of 200 nm or less. The major focus of our efforts was to develop a means of fabricating gratings of 100 nm period. We explored two approaches: e-beam fabrication of x-ray lithography masks, and achromatic holographic lithography. This work was pursued by Erik Anderson as a major component of his Ph.D. thesis. Erik was successful in both the e-beam and holographic approaches. However, the e-beam method proved to be highly impractical: exposure times of about 115 days would be required to cover an area of 1 cm 2 . The achromatic holography, on the other hand, should be capable of exposing areas well in excess of 1 cm 2 in times under 1 hour. Moreover, 100 nm-period gratings produced by achromatic holography are coherent over their entire area whereas gratings produced by e-beam lithography are coherent only over areas /approximately/100 μm. The remainder of this report consists of portions excerpted from Erik Anderson's thesis. These contain all the details of our work on 100 nm period gratings. 26 refs., 17 figs

MPs question reports of citizenship bribery / Ksenia Repson

Index Scriptorium Estoniae

Repson, Ksenia

2005-01-01

Reformierakonna väitel on alusetu seostada rahvastikuminister Paul-Erik Rummo ettepanekut anda teenete eest kodakondsus ärimeestele Sergei Sergejenkovile ja Aleksandr Frolovile ning viimaste soovi ühineda Reformierakonnaga. Mitte-eestlaste osakaal Reformierakonnas

Kui hea pressifoto on hea kunst = Good press photography as good art / Anneli Porri

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2012-01-01

Pressifoto ja kaasaegse kunsti seostest, pressifotost ja fotokunstist. Erik Prozese fotost "Minister, anna aru!" ja fotoseeriast "Eesti portreed taldrikutel", Andres Puttingu fotoseeriast "Suusakuninga tõehetk", Andres Haabu fotost "Lahing pooltühjas kinosaalis"

I eto snezhnaja koroleva?

Index Scriptorium Estoniae

2005-01-01

Taani kunstniku Erik Bagge tööde näitusest "Hans Christian Andersen meie ajal" Tallinna Kultuuritehases Polymer. Kunstniku tööd on inspireeritud Anderseni muinasjuttudest, viikingite ornamentidest ja kaasaja elust

Rakvere Teater mängib Kino-Mati lugu / Toomas Suuman

Index Scriptorium Estoniae

Suuman, Toomas

2002-01-01

Näitleja Erik Ruus Toomas Raudami poolt kirjapandud kinomehaanik Mati Parkja töödest-tegemistest jutustavas näidendis "Kino-Mati. Tema elutee ja juhtumised, mis seal ette tulid", lavastaja Peeter Simm

Kino-Mati näitab Rakveres kino / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2001-01-01

Rakveres tuli lavale Toomas Raudami ja Peeter Simmi näidend Lõuna-Eesti kinomehaaniku Mati Parkja elust "Kino-Mati. Tema elutee ja juhtumised, mis seal ette tulid". Lavastas Peeter Simm, nimiosas Erik Ruus

"Paljutõotavad noored kunstnikud" - igaveseks / Heie Treier

Index Scriptorium Estoniae

Treier, Heie, 1963-

1998-01-01

20. sajandi esimesel poolel noorelt surnud eesti kunstnikke. Euroopa maades suundanäitav inglise graafik Aubrey Beardsley (1872-1898) suri 26-aastaselt. H. Treieri arvates on eesti kunstnikest temaga võrreldav Erik Obermann

Plaadid / Villu Päärt

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2003-01-01

Uutest plaatidest TLC "3D", Audioslave "Audioslave", Too "Through The Looking Glass", Dave Hollister "Things in the Game...", Erik Sermon "React", Family "We Are Family", Eric Clapton "One More Car...", Gianna Nannini "Aria"

Jäätmetega kimpus Estonian Cell annab muda põldudele kompostiks / Ulvar Käärt

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2007-01-01

Kundas asuv Estonian Celli tehas jagab ümberkaudsetele talunikele jäätmetest lahtisaamiseks kompostimissegu. Seadused ei sätesta, kuidas Estonian Cellis tekkivaid jäätmeid töödelda. Kommenteerib Peeter Eek: Aasta läbi ei saa muda põllule viia

Pension pool keskmist palka? / Eiki Nestor

Index Scriptorium Estoniae

Nestor, Eiki, 1953-

2007-01-01

Ilmunud ka: Linnaleht : Tartu, 30. okt. 2007, lk. 8. Poliitik, kes lubab viia keskmise pensioni pooleni keskmisest palgast, kuid võõrtööjõudu Eestisse tuua ei taha, pensioniiga ega sotsiaalmaksu tõsta ei soovi, on autori arvates kas rumal või valetab

Vene muuseum hakkab lagunevat hoonet euromiljonitega elustama / Teele Tammeorg

Index Scriptorium Estoniae

Tammeorg, Teele

2010-01-01

Loodav SA Tallinna Vene Muuseum võtab üle MTÜ Vene Muuseum projektid ja saab muuseumihoone kordategemiseks euroraha taotlema hakata. Koidula t. 23 asuva muuseumile rendile antud hoone seisukorrast. Halbade hoiutingimuste tõttu tuli hoonest ära viia kunstikogu. Hoone renoveerimisprojekt valmis 2006. aastal

A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes)

NARCIS (Netherlands)

ten Cate, H.; Schenk, B. E.; Biemond, B. J.; Levi, M. [=Marcel M.; van der Poll, T.; Buller, H. R.; ten Cate, J. W.

1994-01-01

This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the

Kolmas vaatus Euroopa võlakriisis - Portugal. Oht Portugali mainel / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2011-01-01

Portugal kavatseb läbi viia riigivõlakirjade emissiooni, samas müüvad teisedki riigid lähiajal võlakirju, mille riskiaste on väiksem. Portugal eitab väidet, nagu oleks Saksamaa ja Prantsusmaa survestanud teda Euroopa kriisifondist abi küsima

Kas missioon on moesõna või organisatsiooni "töövahend"? / Alexander Kotchubei

Index Scriptorium Estoniae

Kotchubei, Alexander, 1963-

2004-01-01

Autor selgitab missiooni olemust, selle sõnastamise vajalikkust organisatsioonis ning arutleb võimalike põhjuste üle, miks missioon ei toimi. Kommenteerivad Marie Edala ja Urmas Kaarlep. Lisa: Sõnumi kujundamiseks vali kahe lähenemise vahel. Vt. samas: Kuidas viia missiooni töötajateni?

"Krengolm" obeshtshajet potesnit Pakistan / Irina Tokareva

Index Scriptorium Estoniae

Tokareva, Irina

2008-01-01

Kreenholmi uue peadirektori Igor Poleshtshuki plaani kohaselt tuleks ettevõtte toodangu müügihinnad viia vastavusse maailmaturu hindadega, alandada tootmise omahinda tellimuste arvu suurendamisega, saada tagasi kaotatud tellijad Euroopast ja leida uusi eelkõige Venemaa turult. Ilmunud ka: Narvskaja Nedelja 13. dets. lk. 3

Bernhard Schmidt - realiteet müütide vastu / Ülo Tonts

Index Scriptorium Estoniae

Tonts, Ülo, 1931-2016

1996-01-01

Raamatust Optical illusions. The life story of Bernhard Schmidt the great stellar optician of the twentieth century by Erik Schmidt. Estonian Academy Publishers 1995. B. Schmidt - eestlasest optik, kellest kirjutas J. Kross romaanis "Vastutuulelaev"

Retraction and expansion of flock mobility in central asia: costs and ...

African Journals Online (AJOL)

Retraction and expansion of flock mobility in central asia: costs and consequences. Carol Kerven, Ilya Ilych Alimaev, Roy Behnke, Grant Davidson, Leen Franchois, Nurlan Malmakov, Erik Mathijs, Aidos Smailov, Sayat Temirbekov, Iain Wright ...

Fix 40!

Index Scriptorium Estoniae

2008-01-01

Ansambel Fix peab 13. detsembril Tallinnas Saku Suurhallis oma 40. sünnipäeva. Kontserdi erikülaline on ansambel Apelsin, kaastegevad Jassi Zahharov ja HaleBopp Singers. Õhtut juhib Tarmo Leinatamm

"Kalevipoeg" rootsi kuues / Arvo Mägi

Index Scriptorium Estoniae

Mägi, Arvo, 1913-2004

1999-01-01

rets. rmt.: Kalevipoeg: Estlands nationalepos/samlad och på estniska utgiven av Fr. R. Kreutzwald; i svensk tolkning av Alex Milits; illustrationer av Erik Haamer. Borås : Invandrarförlaget, 1999. 325 lk

The brand of the month - MONTON! / Urmas Väljaots

Index Scriptorium Estoniae

Väljaots, Urmas, 1981-

2003-01-01

AS-i Baltika avalike suhete juht Montoni kaubamärgiga seotud turundustegevusest. Kommenteerivad Audrius Savickas, Aigars Rungis ja Eriks Stendzenieks. Vt. samas intervjuud AS-i Baltika endise turundusjuhi Maarika Liivamäega; Monton chronology

Must maja, valge aed / Mihkel Karu

Index Scriptorium Estoniae

Karu, Mihkel, 1983-

2012-01-01

Laagris 2010. aastal valminud eramust. Tänavapoolne aed on valatud betoonist. Arhitektid: Peeter Pere, Urmas Muru, Anna-Maria Erik (AB Muru & Pere). Sisearhitektid: Katrin Kaevats, Peeter Pere, Urmas Muru. Projekt. 2008. Peeter Pere kommentaar

Poliitikud või eksperdid ? / Aarne Ruben

Index Scriptorium Estoniae

Ruben, Aarne, 1971-

2009-01-01

ETV saates "Foorum" esinesid 21. jaanuaril Indrek Neivelt, Erik Terk, Ivar Raig ja Raivo Vare, kes avaldasid arvamust, et valitsuses oleks vaja rohkem majandusharidusega inimesi. Autori arvates on erialast kõrgharidust vaja kõikjal riigiametites

Tantsupäev toob publiku ette säravaid balletitähti / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2006-01-01

29. apr. esinevad Vanemuises rahvusvaheliselt tuntud tantsijad - Tamara Rojo, Jan-Erik Wikström, Inaki Urlezaga, Anna Valev, Olga Volobujeva, Priit Kripson, Diana Cuni ja Kristoffer Sakurai -, et tähistada rahvusvahelist tantsupäeva

Ülemaailmne mahuti / Siram

Index Scriptorium Estoniae

Siram, pseud., 1968-

2010-01-01

"Global Container X" kunstiüritusest Kunstikonteineris Polymeri kultuuritehases 17. 02. 2010. Osalesid eesti, saksa, kreeka, prantsuse ja kanada kunstnikud. Lähemalt Erik Alalooga müsteeriumist koostöös Hans Günther Lockiga

Illusoorne HIV-vaba Eesti / Nastja Portsjonok

Index Scriptorium Estoniae

Portsjonok, Nastja

2011-01-01

5. juunil 1981 diagnoositi maailmas esimest korda HIV. Eesti on kõige suurema HIV- juhtumite juurdekasvuga riik Euroopa Liidus. Autori hinnangul ei ole me suutnud ennetustööga viia üldist ühiskondlikku ruumi tasemele, mis muudaks vaba seksuaalkäitumise vähem riskantseks

Maksureformist saab valitsuse kirstunael / Kai Kalamees

Index Scriptorium Estoniae

Kalamees, Kai

2005-01-01

2006. aasta eelarve kokkupanemine ja eelarvestrateegia kinnitamine aastateks 2006-2009 võib aprillis-mais koalitsioonipartnerid taas konfliktini viia, kuna kahe järgneva aasta vältel ei ole võimalik samaaegselt langetada tulumaksu 20 protsendini ja täita koalitsioonileppe lubadusi. Lisad: Reformi juhatuses sisepinged; Maksureform

Omavalitsuste rahastamine vajab muutmist / Olev Raju

Index Scriptorium Estoniae

Raju, Olev, 1948-

2002-01-01

Autor leiab, et omavalitsuste rahastamise reform tuleks Eestis läbi viia Euroopa riikide praktikast ja Eesti praeguse arenguetapi majanduspoliitilise olukorra analüüsist lähtuvalt. Tabel: tulumaksu eraldamise diferentseerimise variante omavalitsuste vahel. Summary: The need for reform in local government funding. Autor: Keskerakond. Parlamendisaadik

Benzin iz rapsa : utopija ili realnaja perspektiva? / Oleg Samorodni

Index Scriptorium Estoniae

Samorodni, Oleg, 1961-

2006-01-01

Suurärimees Rein Kilgi eesmärgiks on viia Lõuna Toiduainetööstus Lõuna-Eesti juhtivaks ettevõtteks, seepärast käib ka võitlus rapsitööstuse Werol Tehased ostmise ümber ärimeeste Oliver Kruuda ja Urmas Sõõrumaaga

Peeter Simm kolmandat korda teatris

Index Scriptorium Estoniae

2001-01-01

Rakveres tuli lavale Toomas Raudami ja Peeter Simmi näidend Lõuna-Eesti kinomehaaniku Mati Parkja elust "Kino-Mati. Tema elutee ja juhtumised, mis seal ette tulid". Lavastas Peeter Simm, nimiosas Erik Ruus, kunstnik Hardi Volmer

Browse Title Index

African Journals Online (AJOL)

Items 251 - 300 of 705 ... Vol 11 (2001), From Business Corpus to Business Lexicon, Abstract PDF ... and Jens Erik Mogensen (Editors): Dictionary Visions, Research and Practice. ... Quantitative analyses of revisions in the English and German ...

Saare Jazz toob valguse augustipimedusse

Index Scriptorium Estoniae

2009-01-01

22. augustil Saaremaal Pidula Forelli puhkekülas toimuvast esimesest Saare Jazzist alapealkirjaga "Valgus pimeduses", peaesinejaks laulja Sofia Rubina koos ansambliga Club Eclectic, soojendusesinejaks laulja Teele Viira ja erikülaliseks Soome trompetist Kalevi Louhivuori, esinejatest

Home market is too small for Laima / Uva Seglina

Index Scriptorium Estoniae

Seglina, Uva

2004-01-01

Läti magusatootja Laima turundusjuht ettevõtte tegevusest, eesmärkidest Baltimaade turul, turundusstrateegiast ning olulisematest turundusalastest saavutustest, Laima brändi tugevatest ja nõrkadest. Kommenteerivad Andra Treibaha, Eriks Stenzenieks, Jane Ounaste ja Edgars Skulte

...epater les bourgeois / Riin Kübarsepp

Index Scriptorium Estoniae

Kübarsepp, Riin, 1978-

2004-01-01

Tendentsidest Eesti Kunstiakadeemia ja Academia Grata kevadistes töödes - need on nihilism, skeptitsism, seaduste ja konventsionaalsete põhimõtete eiramine. Pikemalt Marianne Männi ruumiinstallatsioonist "Loom" ja Erik Alalooga magistriprojektist "Välk ja pauk"

The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.

Science.gov (United States)

Li, Tongchao; Giagtzoglou, Nikolaos; Eberl, Daniel F; Jaiswal, Sonal Nagarkar; Cai, Tiantian; Godt, Dorothea; Groves, Andrew K; Bellen, Hugo J

2016-06-22

Myosins play essential roles in the development and function of auditory organs and multiple myosin genes are associated with hereditary forms of deafness. Using a forward genetic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essential gene for auditory organ development. Ubr3 negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. The mono-ubiquitination of Myosin II promotes its physical interaction with Myosin VIIa, a protein responsible for Usher syndrome type IB. We show that ubr3 mutants phenocopy pathogenic variants of Myosin II and that Ubr3 interacts genetically and physically with three Usher syndrome proteins. The interactions between Myosin VIIa and Myosin IIa are conserved in the mammalian cochlea and in human retinal pigment epithelium cells. Our work reveals a novel mechanism that regulates protein complexes affected in two forms of syndromic deafness and suggests a molecular function for Myosin IIa in auditory organs.

Investigation of hexagonal boron nitride as an atomically thin corrosion passivation coating in aqueous solution.

Science.gov (United States)

Zhang, Jing; Yang, Yingchao; Lou, Jun

2016-09-09

Hexagonal boron nitride (h-BN) atomic layers were utilized as a passivation coating in this study. A large-area continuous h-BN thin film was grown on nickel foil using a chemical vapor deposition method and then transferred onto sputtered copper as a corrosion passivation coating. The corrosion passivation performance in a Na2SO4 solution of bare and coated copper was investigated by electrochemical methods including cyclic voltammetry (CV), Tafel polarization and electrochemical impedance spectroscopy (EIS). CV and Tafel analysis indicate that the h-BN coating could effectively suppress the anodic dissolution of copper. The EIS fitting result suggests that defects are the dominant leakage source on h-BN films, and improved anti-corrosion performances could be achieved by further passivating these defects.

Araabia kuum aasta / Erik Männik

Index Scriptorium Estoniae

Männik, Erik, 1967-

2011-01-01

17. detsembril möödus aasta araabia kevade algusest, milleks peetakse hetke, mil Tuneesia kaupmees Mohammad Bouazizi süütas end protestiks ametivõimude vägavalla vastu. Araabia piirkonna prognoos 2012. aastaks

Oliver Peek loob investeerimisveebilehe / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2006-01-01

Rene Ilves uuest investeerimisveebilehest siseinfo.ee. Veebisaidi loojate eesmärk on näidata oma rahapaigutamisloogikat ja anda investoritele ideid, millelt võiks tulu teenida. Lisa: LHV-le ei meeldi blogi nimi

Inflatsioonikeerise järellainetus / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2008-01-01

Autor vaatleb, mis mängib nafta- ja toiduhinna tõusus pearolli. Tema hinnangul võib Eestis näha praegu inflatsioonikeerise järellainetust. Maailma toiduhinna tõus ei pruugi tähendada, et see läheb Eestiski samas tempos edasi

Naftariigid tõmbavad hinnapidurit / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2008-01-01

Investeerimispanga Merrill Lynch tooraineanalüüsi juht Merril Francisco Blanchi prognoosib, et nafta hind langeb madalaimale tasemele 2009. a. esimeses pooles ning alates juunist hakkab hind tõusma. IEA prognoosib, et naftatarbimise kasv aeglustub aastatel 2008-2013 vaid keskmiselt 1,2% võrra. OPEC, kes on viimase kahe kuu jooksul juba vähendanud naftatootmist, võib vastu võtta järjekordse otsuse naftatootmist kärpida. Vt. samas: Naftaspioonide maailm

BP - bisnis põhjas? / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2010-01-01

Seoses Mehhiko lahe naftareostusega ootab BP-d kuni 21 mld. dollari suurune trahv, kahjude hüvitamiseks peab BP müüma osa oma varast. Ekspertide hinnangul tähendavad Mehhiko lahe sündmused suuri muutusi kogu naftaäris

Betamag.ee vahendab oma elukunsti / Anne Vetik

Index Scriptorium Estoniae

Vetik, Anne

2006-01-01

Graafilisele disainile ja popkultuurile pühendatud elektroonilisest ajakirjast Beta. Idee Liisa-Triin Vurmalt ja Jaana Davidjantsilt, kaastööd teevad Tristan Priimägi, Jass Seljamaa ja Erik Morna. Ilmumas neljas Beta, esimene veebruaris 2005

Enhancing Network Communication in NPSNET-V Virtual Environments Using XML-Described Dynamic Behavior (DBP) Protocols

Science.gov (United States)

2001-09-01

1 MCTSSA, Box 555171 Camp Pendelton, CA 92055-5171 15. Erik Chaum ...1 Institute for Defense Analyses 1801 N. Beauregard St. Alexandria, VA 22311-1772 131 18. David ...S. David Kwak .........................................................................................................1 The Mitre Corporation – M

Alytuse biennaal kui kaitsepolügon / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2007-01-01

Leedus Alytuse väikelinnas 20.-26.08.2007 toimunud eksperimentaalkunsti festivalist. II Alytuse biennaali korraldaja Mantas Kazakevicius, osalejad Inglismaalt, Tšehhist, Iirimaalt, Madalmaadest, Lätist, Leedust ja Eestist (Erik Alalooga, Ville Karel Viirelaid ja Sandra Jõgeva)

Molecular and genetic study of wheat rusts

African Journals Online (AJOL)

Nicholas Le Maitre

Phylogenetic trees were created for leaf and stem rust pathotypes. Field isolates of ... Key words: Prevalence, microsatellite, amplified fragment length polymorphisms (AFLP), phylogeny, Puccinia. INTRODUCTION. Puccinia triticina Eriks ..... Genetic distances and reconstruction phylogenetic trees from microsatellite DNA.

Rootsi minister : Eesti majanduses esineb ohumärke / Cecilia Malmström ; interv. Raimo Poom

Index Scriptorium Estoniae

Malmström, Cecilia, 1968-

2008-01-01

Rootsi eurominister vastab küsimustele, mis puudutavad Läänemere strateegia kavandamist, Rootsi suhtumist võimalusse viia Läänemere strateegiaga ellu täielik teenuste vaba liikumine siinses regioonis, Eesti majandusolukorra halvenemist, Swedbanki otsust loobuda Hansapanga nimest, Nord Streami gaasijuhet, eesseisvat referendumit Iirimaal Lissaboni lepingu üle

Symposium des Nordost-Instituts zu seutsch-baltischen diplomatischen Beziehungen / Detlef Henning

Index Scriptorium Estoniae

Henning, Detlef, 1959-

2011-01-01

12. oktoobril 2011 toimus Lüneburgis avatud sümpoosion Baltimaade ja Saksamaa vahel diplomaatiliste suhete taastamise kahekümnenda aastapäeva puhul. Ülevaade toimunust. Lüneburgi valikut hinnati igati õnnestunuks ja järgmisel aastal plaanitakse seal läbi viia loengusari Hansalinnade ajaloo teemal

Relvastatud jõu kasutamine / Kalev Stoicescu

Index Scriptorium Estoniae

Stoicescu, Kalev

2006-01-01

Sõjalistes operatsioonides peavad jõu kasutamise reeglid olema piisavalt selged, nende koostamisel arvestatakse oma riigi seadusi ja rahvusvahelist õigust, kuid ka kohalikku kultuuritausta. Liiga kitsad reeglid võivad piirata sõjalise ülema tegevust, liiga laiad või ähmased reeglid aga võivad viia konflikti eskaleerumisele. Näiteid

Süüdistus: Pärnu meer Viisitamm sai altkäemaksu / Erik Müürsepp, Erik Rand

Index Scriptorium Estoniae

Müürsepp, Ene, 1962-

2009-01-01

Lääne ringkonnaprokuratuur süüdistab Pärnu linnapead Mart Viisitamme ja abilinnapead Simmo Saart saladuse hoidmise kohustuse rikkumises ja usalduse kuritarvitamises. Linnapead süüdistatakse samuti ka altkäemaksu võtmises Tänavapuhastuse AS-ilt. Vt. samas: Lutikatõrje ei aidanud

Reisifirma tõrjub Kesklinna vanema soovi raha tagasi saada / Urmas Seaver

Index Scriptorium Estoniae

Seaver, Urmas, 1973-

2002-01-01

Kesklinna vanema Erik Siiguri väitel asub Kesklinna valitsus reisikorraldajalt OÜ Helke ligi 27000 kr. kohtu kaudu tagasi nõudma, kui firma ise ei maksa, sest Helke lubas linnaosa valitsuse ametnikele Pariisis rohkem koolitust, kui hiljem pakkus

Värviküllane elujanu / Tiina Tammet

Index Scriptorium Estoniae

Tammet, Tiina, 1971-

2004-01-01

Suurbritannia Vähiuuringute keskusele loodud Elu Aed 2004. a. Chelsea aiandusnäitusel. Aia kujundasid Jane Hudson & Erik de Maeijer. Mosaiiktee autor Maggy Howarth. Soojades toonides külluslik lilleaed sisendab elujõudu, vabadust ja energiat. 4 ill

Ih bõ ustami da med pit / Andrei Babin

Index Scriptorium Estoniae

Babin, Andrei

2003-01-01

17 analüütiku seas läbi viidud küsitluse tulemustest Euroopa Liiduga ühinemise mõjudest Eestile. Artikkel sisaldab intervjuud analüütik Erik Tergiga. Graafik: EL-iga liitumise mõju Eesti majandusele

Eesti ajalehefoto 2004 : kuhu kadusid aasta tipphetked? / Väino Koorberg

Index Scriptorium Estoniae

Koorberg, Väino, 1969-

2005-01-01

Kokkuvõte žürii tööst. Parim uudisfoto Raul Mee töö "Eesti-Rootsi 1:O", maakonnalehtede parim Margus Ansu foto Laine Jänesest, parim olemusfoto Erik Prozese "Peremudel muutuvas ühiskonnas". 8 fotot

Is prophylaxis required for delivery in women with factor VII deficiency?

Science.gov (United States)

Baumann Kreuziger, L M; Morton, Colleen T; Reding, Mark T

2013-11-01

Factor VII (fVII) deficiency is a rare congenital bleeding disorder in which fVII activity level and bleeding tendency do not completely correlate. Pregnancy and delivery present a significant haemostatic challenge to women with fVII deficiency. Treatment with recombinant factor VIIa (rfVIIa) carries a thrombotic risk and the literature is not clear whether prophylaxis is necessary prior to delivery. The aim of this study was to define management, haemorrhagic and thrombotic complications of pregnant women with fVII deficiency through a systematic review. Medical databases (PubMed, MEDLINE, CINAHL, Academic Search Premier, Cochrane Library, Web of Science and Scopus) were searched using "factor VII deficiency" and "pregnancy" or "surgery." Overall 34 articles, four abstracts, and three institutional cases were reviewed. Literature from 1953 to 2011 reported 94 live births from 62 women with fVII deficiency. The median fVII activity was 5.5%. Haemostatic prophylaxis was used in 32% of deliveries. Without prophylaxis, 40 vaginal deliveries and 16 caesarean sections were completed. The odds of receiving prophylaxis were 2.9 times higher in women undergoing caesarean section compared to vaginal delivery. Post-partum haemorrhage occurred in 10% of deliveries with prophylaxis and 13% of deliveries without prophylaxis. The fVII level did not significantly differ between women who did and did not receive prophylaxis. We present the only systematic review of the management of pregnancy in fVII deficient women. No difference in post-partum haemorrhage was seen in deliveries with and without prophylaxis. Therefore, we recommend that rfVIIa be available in the case of haemorrhage or surgical intervention, but not as mandatory prophylaxis. © 2013 John Wiley & Sons Ltd.

Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans.

Directory of Open Access Journals (Sweden)

Fabio Demontis

Full Text Available BACKGROUND: The Usher syndrome (USH is the most frequent deaf-blindness hereditary disease in humans. Deafness is attributed to the disorganization of stereocilia in the inner ear. USH1, the most severe subtype, is associated with mutations in genes encoding myosin VIIa, harmonin, cadherin 23, protocadherin 15, and sans. Myosin VIIa, harmonin, cadherin 23, and protocadherin 15 physically interact in vitro and localize to stereocilia tips in vivo, indicating that they form functional complexes. Sans, in contrast, localizes to vesicle-like structures beneath the apical membrane of stereocilia-displaying hair cells. How mutations in sans result in deafness and blindness is not well understood. Orthologs of myosin VIIa and protocadherin 15 have been identified in Drosophila melanogaster and their genetic analysis has identified essential roles in auditory perception and microvilli morphogenesis, respectively. PRINCIPAL FINDINGS: Here, we have identified and characterized the Drosophila ortholog of human sans. Drosophila Sans is expressed in tubular organs of the embryo, in lens-secreting cone cells of the adult eye, and in microvilli-displaying follicle cells during oogenesis. Sans mutants are viable, fertile, and mutant follicle cells appear to form microvilli, indicating that Sans is dispensable for fly development and microvilli morphogenesis in the follicle epithelium. In follicle cells, Sans protein localizes, similar to its vertebrate ortholog, to intracellular punctate structures, which we have identified as early endosomes associated with the syntaxin Avalanche. CONCLUSIONS: Our work is consistent with an evolutionary conserved function of Sans in vesicle trafficking. Furthermore it provides a significant basis for further understanding of the role of this Usher syndrome ortholog in development and disease.

A study of the inhibition of iron corrosion in HCl solutions by some amino acids

International Nuclear Information System (INIS)

Amin, Mohammed A.; Khaled, K.F.; Mohsen, Q.; Arida, H.A.

2010-01-01

The performance of three selected amino acids, namely alanine (Ala), cysteine (Cys) and S-methyl cysteine (S-MCys) as safe corrosion inhibitors for iron in aerated stagnant 1.0 M HCl solutions was evaluated by Tafel polarization and impedance measurements. Results indicate that Ala acts mainly as a cathodic inhibitor, while Cys and S-MCys function as mixed-type inhibitors. Cys, which contains a mercapto group in its molecular structure, was the most effective among the inhibitors tested, while Ala was less effective than S-MCys. The low inhibition efficiency recorded for S-MCys compared with that of Cys was attributed to steric effects caused by the substituent methyl on the mercapto group. Electrochemical frequency modulation (EFM) technique and inductively coupled plasma atomic emission spectrometry (ICP-AES), were also applied to make accurate determination of corrosion rates. Validation of the Tafel extrapolation method for measuring corrosion rates was tested. Rates of corrosion rates (in μm y -1 ) obtained from Tafel extrapolation method are in good agreement with those measured using EFM and ICP methods. Some theoretical studies, including molecular dynamics (MD) and density functional theory (DFT), were also employed to establish the correlation between the structure (molecular and electronic) of the three tested inhibitors and the inhibition efficiency. Adsorption via hydrogen bonding was discussed here based on some theoretical studies. Experimental and theoretical results were in good agreement.

Turkka, Nokia-Ollila ja Rosa Luxemburg / Tambet Kaugema

Index Scriptorium Estoniae

Kaugema, Tambet

2001-01-01

Von Krahli Teatris esietendus Jouko Turkka näidend "Connecting people", lavastaja Erik Söderblom Soomest, kunstnik Liina Keevallik. Esietendus 15. jaan. Arvamusi lavastusest avaldavad ka kultuuritoimetaja Valle-Sten Maiste, meediaärimees Rein Lang ja teatrijuht Peeter Jalakas

Hudozhestvennaja akademija pomogajet naiti svojo litso

Index Scriptorium Estoniae

2008-01-01

Eesti Kunstiakadeemia osalemisest innovatsiooniprogrammis Spinno. Projekti eesmärgiks on viia kokku disainiõppureid ja ettevõtteid, suurendada ettevõtjate teadmisi disainist. Spinno raames käivitati Disainiaasta ja Arhitektuuriaasta projektid. Kommenteerib projektijuht Sven Idarand. Tootedisainiga tegelevast Eesti Kunstiakadeemia esimesest spin-off ettevõttest Taikonaut räägib Kristiina Tuubel

Eesti ja Venemaa uue külma sõja õhutamise avangardis / Herbert Vainu

Index Scriptorium Estoniae

Vainu, Herbert, 1929-2011

2008-01-01

Eesti ja Venemaa juhtide mängimine rahvustundel tõstab rahvusvahelist pinget, mis võib viia külma sõja taastekkimisele. Autor kritiseerib muuhulgas president Toomas Hendrik Ilvese poliitilist tegevust ja esinemist Hantõ-Manskiiskis toimunud soome-ugri maailmakongressil. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

Ajateenistusest, ausalt! / Kim Järvepõld

Index Scriptorium Estoniae

Järvepõld, Kim

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke, 9. apr. 2007, lk. 7. Autor leiab, et põhiseaduslik nõue, mille järgi on kõik Eesti kodanikud kohustatud osa võtma riigikaitsest, pole vastavuses tegeliku olukorraga, ning arvab, et kohustuslik ajateenistus tuleb kaotada või viia kooskõlla põhiseadusega

Klaasist ringhäälingumaja tuleb energiasäästlik

Index Scriptorium Estoniae

2007-01-01

Kultuuriminister Laine Jänes vastuseks erakonna Eestimaa Rohelised Riigikogu fraktsiooni aseesimehe Marek Strandbergi päringule uue ringhäälingumaja energiakuludest. Hoone projekteerimisel võetakse aluseks arhitektuurivõistluse võidutöö, mille autor on taani arhitekt Erik Nobel

Enlightenment Christianity, History and Opera

DEFF Research Database (Denmark)

Petersen, Nils Holger

2010-01-01

Historisk præsentation af Kunzens og Baggesens opera "Erik Eiegod", litterært og musikalsk med vægt på balancen mellem oplysningsideologi og kristendomsforståelse i Baggesens libretto og på Kunzens musikalske underbygning heraf. Udgivelsesdato: 2010...

Sõprus äratab! : Ärkamised ja karjed kino Sõpruse ajaloos / Laura Talvet

Index Scriptorium Estoniae

Talvet, Laura

2010-01-01

Kinos Sõprus näidati 1990ndate alguses punkansamblist Sex Pistols' valminud dokumentaalfilmi "The Great Rock'N'Roll Swindle" (Suurbritannia 1980), režissöör Julien Temple. Artiklis tsiteeritakse Juq-Kalle Raidi, Kojamehe, Erik Morna ja Tõnu Trubetsky muljeid

10. Temadag indenfor Koordinatmåling

DEFF Research Database (Denmark)

Larsen, Erik; De Chiffre, Leonardo

2004-01-01

Temadag om Optisk koordinatmåling, 3D digitalisering og Reverse Engineering Conference on Optical Coordinate Metrology, 3D Digitisation and Reverse Engineering Konferencemappe Oktober 2004 Editorer: Leonardo De Chiffre & Erik Larsen Institut for Produktion og Ledelse Danmarks Tekniske Universitet...

'We zijn nu de beste in bioplastics'

NARCIS (Netherlands)

Seventer, van E.

2012-01-01

‘Toen we begonnen was Wageningen UR landbouw en voeding. Nu zijn we ook goed in bioplastics’, zegt Erik van Seventer van Wageningen UR Food & Biobased Research. De investering in onderzoek voor een biobased economie heeft duidelijk zijn vruchten afgeworpen.

Eetiline või normatiivne etteheide? : süü mõistest kriminaalõiguses / Jaan Sootak

Index Scriptorium Estoniae

Sootak, Jaan, 1948-

1998-01-01

Süü mõistest õigusfilosoofias ja kriminaalõigusdogmaatikas, klassikalisest kuriteomõistest, Erik Wolfi normatiivsest kurjategijatüübist, eluviisisüüst ja iseloomusüüst, tahtevabadusest, relatiivsest indeterminismist ning süüst kui ühiskondlikust nähtusest

R.E.M.i loomingut saadab abivajajate hääl / Anniki Leppik

Index Scriptorium Estoniae

Leppik, Anniki

2008-01-01

11. sept. Tallinnas Saku Suurhallis esinevast ameerika rockansamblist R.E.M., kes toob kaasa heategevusorganisatsioonid Amnesty International ja Oxfam International. Eestis tutvustab ansambel oma 14. stuudioalbumit "Accelerate", erikülaliseks on tantsulise indie-roki bänd We Are Scientists

Testicular Microlithiasis: Is It Associated with Testicular Cancer?

Science.gov (United States)

... Is there a link between testicular microlithiasis and testicular cancer? Answers from Erik P. Castle, M.D. Testicular microlithiasis (tes-TIK-yoo- ... studies show a relationship between testicular microlithiasis and testicular cancer. However, it remains unclear whether having testicular microlithiasis ...

Latvijas Gaze buyback likely to flop

Index Scriptorium Estoniae

2003-01-01

Veerandi Läti gaasifirma Latvijas Gaze omanik Itera kavatseb lähiajal lõpule viia üheksa protsendi Läti firma aktsiate müügi ettevõttele Gazprom. Gazprom'i kontrolli all on praegu 25 protsenti, Ruhrgas'il 28,66 ning E.ON Energie AG-l 18,06 protsenti Latvijas Gaze aktsiatest

75 FR 76930 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

Science.gov (United States)

2010-12-10

... specially designed for producing, processing, or using: (i) WMDs; (ii) Special nuclear materials; or (iii...)(2)(iii): VII(a)(2)(iii) also includes B kits (add-on armor). (iv) (Tier 3) Deep water fording kits... instructions written or recorded on other media or devices such as disk, tape, read-only memories. Dated...

Lääne- ja Ida-Virumaal satub löögi alla tuhatkond töökohta / Raivo Raigna

Index Scriptorium Estoniae

Raigna, Raivo

2009-01-01

Puidu põletamine elektrijaamades on tõstnud ümarpuidu hinda Virumaal kuni 40%, selline kunstlik ja järsk toorme hinnatõus hävitab kahe Virumaa suurtööandja, puitlaastplaatide tootja Repo Vabrikud ja puitmassitehase Estonian Cell konkurentsivõime rahvusvahelistel turgudel ning võib viia sadade töökohtade kaotuseni

Cast iron deterioration with time in various aqueous salt solutions

Indian Academy of Sciences (India)

Unknown

various aqueous salt solutions have been carried out using total immersion test ... circuit potential, Icorr, Tafel slopes, corrosion rate, have been calculated by standard methods. ..... Rao B V S 1980 in Maintenance for reliability (Bombay: Media.

Narrative, Nanotechnology and the Accomplishment of Public Responses

DEFF Research Database (Denmark)

Kearnes, Matthew; Macnaghten, Phil; Davies, Sarah Rachael

2014-01-01

In this paper, we respond to a critique by Erik Thorstensen of the ‘Deepening Ethical Engagement and Participation in Emerging Nanotechnologies’ (DEEPEN) project concerning its ‘realist’ treatment of narrative, its restricted analytical framework and resources, its apparent confusion in focus...

Meri, munklus ja tööstusmaastik / Kaire Nurk

Index Scriptorium Estoniae

Nurk, Kaire, 1960-

2003-01-01

Video-tegevuskunsti sündmus "Saar 2003" 5. juulil Viinistus ja Mohnil. Osa võtsid Erik Alalooga, sakslased Uwe Schloen ja Georg Janthur, Jaan Toomik, Jaan Paavle, Silja Saarepuu, Villu Plink, Jüri Ojaver, venelanna Tatjana Goloviznina, lõuna-aafriklane Steven Cohen

Tshto ostalos za kadrom / Jevgeni Ashihmin

Index Scriptorium Estoniae

Ashihmin, Jevgeni

2003-01-01

Sillamäe kultuurikeskuses näidati uut dokumentaalfilmi Sillamäe pensionäride ühenduse aktivisti Esja Shuri võitlusest oma õiguste eest "Meeleavaldaja" : režissöör ja produtsent Meelis Muhu : operaator Erik Norkroos : In Ruum 2003

Oma ala meistriks saab igaüks isemoodi / Anna-Liisa Mets

Index Scriptorium Estoniae

Mets, Anna-Liisa

2014-01-01

Selgusid kutsemeistrivõistluse "Noor meister 2014" parimad. Edukalt esinenud õppurid meisterkondiiter Helen Laht, ehituspuussepp Mirko Pruus, logistik Karl-Erik Maripuu, keskkonnatehnika lukksepp Robert Born, elektrik Tiit Talts ja müürsepp Sander Hindrikus räägivad oma ametiõpingutest ja tulevikuplaanidest

Identity Exploration: A "Crisis" Which May Go Unnoticed in Gifted Adolescents.

Science.gov (United States)

Kidwell, Jeannie; And Others

1995-01-01

Correlation of 82 academically gifted adolescents' personality scores with scores for identity exploration revealed that youth who were actively exploring (according to Erik Erikson's ego identity theory) exhibited the following psychological portrait: inner confusion, agitation, dissatisfaction, unhappiness, periodic spells of depression,…

Narva keskosa planeeringu võistlus = Narva Central Area Planning Competition

Index Scriptorium Estoniae

2001-01-01

Rahvusvahelise arhitektuurivõistluse zürii koosseis. Preemiad: I - Inga Raukas, Toomas Tammis, Tarmo Teedumäe; II - Erik Nobel (Kopenhaagen); III - Mark Hemel, Barbara Kuit (London); ost - Villem Tomiste ja Veronika Valk ning Richard Havenhand, Gregg Wilson ja Steve Kemp (Lincoln, Inglismaa).

Tallinna Kunstihoones on skriinseiver

Index Scriptorium Estoniae

2003-01-01

21. II-16. III eesti-läti-leedu-inglise ühisprojekt "Skriinseiver". Projekti eesotsas on kuraatorid Anders Härm, Hanno Soans ja troubleproduction. Esinevad Eriks Bozhis (Läti), Darius Mikshys (Leedu), John Frankland (Inglismaa), troubleproductions, ESTO TV ja 11 osalejat Eestist

Viking Line visandab oma laevadele purjeid / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2008-01-01

Viking Line'i juht Nils-Erik Eklund leiab, et Tallinki uued laevad on pigem probleem kui konkurentsieelis, sest uue põlvkonna reisilaevad peaks liikuma osaliselt tuule- ja päikeseenergia jõul. Vt. samas: Tallinna-Helsingi liinil on tasakaal lähedal

Teenetemärgid

Index Scriptorium Estoniae

2005-01-01

Tartu Ülikooli kollektiivi liikmetest saavad Eesti vabariigi 87. aastapäeva puhul riikliku autasu külalisprofessorid Stig Erik örjan Ohlsson ja Uno lõhmus, professorid mati Erelt, Volli kalm, kalle merusk, Aadu Must, Paul varul, Jaan Eha, bibliograaf Marika Meltsas

Think Human

DEFF Research Database (Denmark)

Nielsen, Charlotte Marie Bisgaard

2012-01-01

Artiklen analyserer maskinmetaforik med eksempel i Sundhedsstyrelsens uge-40 kampagne. Indledningsvis beskriver forfatteren baggrunden for den sproglige aflejring der af Erik Hollnagel og Roy Harris benævnes som "maskinmetaforer". Maskinmetaforer beskrives siden i teori og praksis, særligt i kamp...

Esimene Eesti maja Hiinas = The first Estonian house in China / Andres Põime, Lauri Vaimel ; interv. Triin Ojari

Index Scriptorium Estoniae

Põime, Andres

2008-01-01

Vestlus Pekingi Eesti saatkonna arhitektuurikonkursi võidutöö autoritega. Tulemused: I preemia - Andres Põime, Lauri Vaimel, II - Erik Nobel, Christian Jensen, Kristen Herup Sovang, Soren Andersson, Pille Kivihall, Dan Ljungar, Hans Willadsen (Taani), III - Kalle Vellevoog, Velle Kadalipp, Tiiu Truus, Martin Prommik

Creativity and the Child's Social Development.

Science.gov (United States)

Nabors, Martha L.; Edwards, Linda C.

1994-01-01

Presents three teacher-preschooler scenarios illustrating teacher actions that hinder creativity and social development. Discusses the connection between psychosocial and creative development in light of Erik Erikson's eight stages of psychosocial development. Suggests that teachers need to be flexible, consider children's feelings, foster…

Vegetation patterns, runoff, sediment delivery and organic carbon output from a small catchment in SE Spain

NARCIS (Netherlands)

Cammeraat, E.

2011-01-01

Vegetation patterns, runoff, sediment delivery and organic carbon output from a small catchment in SE Spain Erik Cammeraat Spatial patterns of vegetation are strongly affecting the pathways and connectivity of water, sediments and associated organic matter, and this study aims at understanding the

EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat.

Directory of Open Access Journals (Sweden)

Marisa Zallocchi

Full Text Available Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment epithelia (RPE and/or photoreceptors leads to blindness. We evaluated the impact of subretinally delivered UshStat, a recombinant EIAV-based lentiviral vector expressing human MYO7A, on photoreceptor function in the shaker1 mouse model for Usher type 1B that lacks a functional Myo7A gene. Subretinal injections of EIAV-CMV-GFP, EIAV-RK-GFP (photoreceptor specific, EIAV-CMV-MYO7A (UshStat or EIAV-CMV-Null (control vectors were performed in shaker1 mice. GFP and myosin VIIa expression was evaluated histologically. Photoreceptor function in EIAV-CMV-MYO7A treated eyes was determined by evaluating α-transducin translocation in photoreceptors in response to low light intensity levels, and protection from light induced photoreceptor degeneration was measured. The safety and tolerability of subretinally delivered UshStat was evaluated in macaques. Expression of GFP and myosin VIIa was confirmed in the RPE and photoreceptors in shaker1 mice following subretinal delivery of the EIAV-CMV-GFP/MYO7A vectors. The EIAV-CMV-MYO7A vector protected the shaker1 mouse photoreceptors from acute and chronic intensity light damage, indicated by a significant reduction in photoreceptor cell loss, and restoration of the α-transducin translocation threshold in the photoreceptors. Safety studies in the macaques demonstrated that subretinal delivery of UshStat is safe and well-tolerated. Subretinal delivery of EIAV-CMV-MYO7A (UshStat rescues photoreceptor phenotypes in the shaker1 mouse. In addition, subretinally delivered UshStat is safe and well-tolerated in macaque safety studies These data support the clinical development of UshStat to treat Usher type 1B syndrome.

EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat.

Science.gov (United States)

Zallocchi, Marisa; Binley, Katie; Lad, Yatish; Ellis, Scott; Widdowson, Peter; Iqball, Sharifah; Scripps, Vicky; Kelleher, Michelle; Loader, Julie; Miskin, James; Peng, You-Wei; Wang, Wei-Min; Cheung, Linda; Delimont, Duane; Mitrophanous, Kyriacos A; Cosgrove, Dominic

2014-01-01

Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment epithelia (RPE) and/or photoreceptors leads to blindness. We evaluated the impact of subretinally delivered UshStat, a recombinant EIAV-based lentiviral vector expressing human MYO7A, on photoreceptor function in the shaker1 mouse model for Usher type 1B that lacks a functional Myo7A gene. Subretinal injections of EIAV-CMV-GFP, EIAV-RK-GFP (photoreceptor specific), EIAV-CMV-MYO7A (UshStat) or EIAV-CMV-Null (control) vectors were performed in shaker1 mice. GFP and myosin VIIa expression was evaluated histologically. Photoreceptor function in EIAV-CMV-MYO7A treated eyes was determined by evaluating α-transducin translocation in photoreceptors in response to low light intensity levels, and protection from light induced photoreceptor degeneration was measured. The safety and tolerability of subretinally delivered UshStat was evaluated in macaques. Expression of GFP and myosin VIIa was confirmed in the RPE and photoreceptors in shaker1 mice following subretinal delivery of the EIAV-CMV-GFP/MYO7A vectors. The EIAV-CMV-MYO7A vector protected the shaker1 mouse photoreceptors from acute and chronic intensity light damage, indicated by a significant reduction in photoreceptor cell loss, and restoration of the α-transducin translocation threshold in the photoreceptors. Safety studies in the macaques demonstrated that subretinal delivery of UshStat is safe and well-tolerated. Subretinal delivery of EIAV-CMV-MYO7A (UshStat) rescues photoreceptor phenotypes in the shaker1 mouse. In addition, subretinally delivered UshStat is safe and well-tolerated in macaque safety studies These data support the clinical development of UshStat to treat Usher type 1B syndrome.

St. Ola sõitis Virumaa lipulaevana Soome / Gerli Romanovitsh

Index Scriptorium Estoniae

Romanovitš, Gerli, 1977-

2005-01-01

Ilmunud ka: Severnoje Poberezhje 10. juuni lk 1,4. Parvlaev St. Ola alustas sõitu Sillamäelt Kotkasse, et viia Ida-Virumaa esindajad Kouvolas toimuvale messile, millest poole võtab enda alla Virumaa väljapanek. Järgmisel aastal käivitub Sillamäe-Kotka regulaarlaevaliin. Ida-Viru maavanema Ago Silde kommentaar

Coagulation for the clinician

African Journals Online (AJOL)

and activates factor X at a 50 - 100-fold higher rate than the factor VIIa-tissue factor complex, ... participate in the formation of vitamin K-dependent protein complexes. .... XIII,67 which covalently cross-links the fibrin polymers both longitudinally and ...... as it deserves a new evaluation leading to a final validation. TAble I. TeG ...

XXI sajandil võib vabalt puhkeda demokraatia kriis / Jaan Kaplinski

Index Scriptorium Estoniae

Kaplinski, Jaan, 1941-

2007-01-01

Ilmunud ka: Delovõje Vedomosti 4. apr. lk. 12. Autor usub, et XXI sajand saab otsustavaks ajaks nii inimsoo kui ka demokraatia jätkusuutlikkusele. Pole võimatu, et elatustaseme langus ja suure osa inimeste võimetus sellega leppida ning leida võimalus ka kasinates tingimustes hästi elada võib viia demokraatia kriisile

Mazheikiu tehast varustav Vene naftajuhe kuival / Martti Kass

Index Scriptorium Estoniae

Kass, Martti

2006-01-01

Delfi.lv andmetel pole juba kaheksa päeva Mazheikiai naftatehas Venemaalt naftat saanud. Lätis prognoositakse bensiinihinna olulist tõusu. USA suursaadik Leedus Keith Smith on hoiatanud, et Mazheikiai naftatehasel võib uue omaniku käe all tarneprobleeme tekkida, tema väitel on tunda survet, et Mazheikiai naftatehas taas Venemaa omandusse viia

Institute for Plasma Research, Stuttgart University. Annual report 1986

International Nuclear Information System (INIS)

1987-01-01

In 1986 the IPP-IPF cooperation in the field of fusion related research and development has been successfully continued. The ECRH project as the largest activity is concentrated on the completion of the 1 MW/70 GHz long-pulse ECRH-system for the W VII-AS stellarator. The components tests promise optimum technical and - hopefully - physical results. Theoretical investigations mainly concern ray propagation and time dependent transport calculations for stellarators at ECRH conditions. A first successful experimental demonstration of the LIDAR scattering concept on JET was a rather encouraging progress for the laser diagnostic group. Besides this project the FIR scattering was continued on ASDEX with measurements of the k-spectra of the low frequency fluctuations during the various kinds of plasma heating. On the WEGA stellarator a programme of flux surface measurements with electron beams has been started. A meanwhile improved detection method will be applied - in cooperation with the Wendelstein team - at the coming W VII-AS stellarator. In the last year the plasma focus experiment POSEIDON achieved successful operation at full bank energy. (orig.)

Perspectives on confinement in helical systems

International Nuclear Information System (INIS)

Itoh, Kimitaka; Itoh, Sanae

1989-01-01

A review on recent experimental results and theoretical models on anomalous transport and density limit in toroidal helical devices is presented. Importance of transport problems is discussed. Experiments on Heliotron-E, Wendelstein-VIIA and new devices, i.e., ATF, Wendelstein-VIIAS and CHS, are reviewed and an overview on confinement property is given. From recent experimental results one sees that there are anomalous transport, which increases with temperature, and density limit, and that they limit the energy confinement time as well as the attainable beta value. The confinement characteristics of the scrape off layer plasma and loss cone loss are discussed, and perspectives on the high temperature plasma are given. These anomalous transport and density limit will be difficult obstacles in realizing a reactor grade plasma in helical systems. It is an urgent task to draw a realistic picture of the confinement based on the present data base. The relevant knowledge now would be critically essential for the successful development of the research in 1990's. (author) 102 refs

A Novel Homozygous MYO7A Mutation: Case Report

Directory of Open Access Journals (Sweden)

Mahsa Ahmadi

2018-05-01

Full Text Available MYO7A is an unconventional myosin that is essential for ordinary hearing and vision; mutations in the MYO7A gene result in Usher syndrome type 1B and other disorders. In this manuscript, we reported a mutation (c.4705delA in exon 35, causing the alteration of a Ser amino acid to Ala at codon 1569 (p.H2027del located within the first FERMdomain of the human protein myosin VIIA. This mutation involved in the pathogenesis of hearing loss, congenital night blindness, muscular weakness, skin problem, and difficulty in keeping balance in the 13-year-old female. After checkup the patient’s DNA was extracted from peripheral blood and amplification was performed by PCR. Sequencing method was performed for identification of the mutation. The c.4705delA mutation in exon 35 was found in the patient in heterozygosis form; this means that her mother and father were carriers. This mutation is located on the tail of the myosinVIIA protein and is associated with several disorders.

The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals

Science.gov (United States)

Li, Tongchao; Giagtzoglou, Nikolaos; Eberl, Daniel F; Jaiswal, Sonal Nagarkar; Cai, Tiantian; Godt, Dorothea; Groves, Andrew K; Bellen, Hugo J

2016-01-01

Myosins play essential roles in the development and function of auditory organs and multiple myosin genes are associated with hereditary forms of deafness. Using a forward genetic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essential gene for auditory organ development. Ubr3 negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. The mono-ubiquitination of Myosin II promotes its physical interaction with Myosin VIIa, a protein responsible for Usher syndrome type IB. We show that ubr3 mutants phenocopy pathogenic variants of Myosin II and that Ubr3 interacts genetically and physically with three Usher syndrome proteins. The interactions between Myosin VIIa and Myosin IIa are conserved in the mammalian cochlea and in human retinal pigment epithelium cells. Our work reveals a novel mechanism that regulates protein complexes affected in two forms of syndromic deafness and suggests a molecular function for Myosin IIa in auditory organs. DOI: http://dx.doi.org/10.7554/eLife.15258.001 PMID:27331610

Propagation of steel corrosion in concrete: Experimental and numerical investigations

DEFF Research Database (Denmark)

Michel, Alexander; Otieno, M.; Stang, Henrik

2016-01-01

This paper focuses on experimental and numerical investigations of the propagation phase of reinforcement corrosion to determine anodic and cathodic Tafel constants and exchange current densities, from corrosion current density and corrosion potential measurements. The experimental program includ...

The Forgotten Disaster Victim: Reducing Responder Injury

Science.gov (United States)

2017-03-01

Approved by: Anke Richter Thesis Advisor Michael Petrie EMS Bureau, County of Monterey Second Reader Erik Dahl Associate Chair for Instruction...RESPONDERS IN DISASTERS .............20 1. Oklahoma City Bombing .............................................................20 2. World Trade Center...Categories, 2008–2014..................................................................................................19 Figure 4. Oklahoma City Bombing

[Raamat] / Sergei Stadnikov

Index Scriptorium Estoniae

Stadnikov, Sergei, 1956-

2003-01-01

Arvustus: Enuma elish : Babüloonia loomiseepos / [akkadi keelest tõlkinud ja eessõna: Amar Annus]. Tallinn : Kirjastuskeskus, 2003 ; Gudea. Kuningas Gudea templihümn / [sumeri keelest tõlkinud: A-silinder: Sven-Erik Soosaar ; B-silinder: Amar Annus ; eessõna: Amar Annus]. Tallinn : Kirjastuskeskus, 2002

Ühe sümptomi kirjeldus - Sillamäe Jeanne D'Arc / Karol Ansip

Index Scriptorium Estoniae

Ansip, Karol

2003-01-01

Dokumentaalfilm Sillamäe pensionäride ühenduse aktivisti Esja Shuri võitlusest oma õiguste eest "Meeleavaldaja" : stsenarist, režissöör ja produtsent Meelis Muhu : operaator Erik Norkroos : In Ruum 2003. Lisatud andmed M. Muhu senise loomingu kohta lk. 112

The "Special" World: Stalin's Power Apparatus and the Soviet System's Secret Structures of Communication"

DEFF Research Database (Denmark)

Villaume, Poul

2009-01-01

Bogomtale - aspekter af Niels Erik Rosenfeldts store disputats om Stalin-tidens hemmelige magt- og kommunikationsapparat diskuteres. Bogen fokuserer på systemets struktur, anatomi, procedurer og beslutningsprocesser, men sociologisk bureaukrati-teori kunne med fordel være anvendt. Værket vil være...

Case report

African Journals Online (AJOL)

abp

2017-06-29

Jun 29, 2017 ... described by the Finish physician Erik von Willebrand in 1926. VWD ... on day 4 and showed normal factor IX level but factor VIII level was low at 16.6%. ... and hemophilia A or between VWD 2B and a platelet disorder.

derivatives: Synthesis and antimicrobial evaluation

Indian Academy of Sciences (India)

cal activity study revealed that all compounds showed promising activities and bis-(1H-2-benzopyran-1-one) derivatives (5) ...... A and Galvez J 2004 Planta Med. 70 315. 6. ... Ante N, Erik De C, Jan B and Mladen M 2011 Molecules. 16 6023.

Recovered-Resource Dependent Industries and the Strategic Renewal of Incumbent Firms: A Multi-Level Study of Recovered-Resource Dependence Management and Strategic Renewal in the European Paper and Board Industry

NARCIS (Netherlands)

E. van Leeuwen (Erik)

2007-01-01

textabstractErik P. van Leeuwen (Gouda, Netherlands, January 5, 1974) began his study Mechanical Engineering at the Polytechnics Department of the HTS Dordrecht and specialised in Energy Management. After receiving his Bachelor degree in 1997, he wanted to enlarge his management knowledge by taking

Uus rahvusringhäälingu hoone rõhutab läbipaistvust / Oliver Õunmaa

Index Scriptorium Estoniae

Õunmaa, Oliver

2007-01-01

Eesti Rahvusringhäälingu hoone arhitektuurikonkursi võitis Erik Nobel Taani arhitektuuribüroost Nobel Arkitekter A/S. Teise koha saavutasid Trevor Harris ja Taru Niskanen Soome arhitektuuribüroost Arkkitehtitoimisto Harris ja Kjisk Oy. Maja ehitatakse Tallinnasse Tuisu tänav 12

Kunst viib saunakultuuri maakera kuklapoolele

Index Scriptorium Estoniae

2010-01-01

Kultuuritehases Polymer tegutsev Art Container tutvustab Austraalias Brisbane'i festivalil eesti saunakultuuri. Eksponeeritakse arhitektuurilist installatsiooni (kasutatud akendest ehitatud läbipaistev saun) ja esitatakse interaktiivset performance'it "Kümblejad". Töö autorid on Erik Alalooga, Tanel Saar, Sandra Jõgeva, Janno Bergmann, Hans-Gunter Lock

Erikson's Psychosocial Theories Help Explain Early Adolescence.

Science.gov (United States)

Manning, M. Lee

1988-01-01

Middle school educators can design a learning environment for early adolescents based on Erik Erikson's social development theories, which divide human life into eight psychological stages. The identity versus role confusion stage characterizing adolescence will significantly determine the developing person's future. Schools can help learners…

Selskabsskatteret 2008/09

DEFF Research Database (Denmark)

Werlauff, Erik

Værket er 10. udgave af professor, dr. jur. ERIK WERLAUFF's klassiker "Selskabsskatteret". Værket giver et samlet billede af selskabs-, fonds- og foreningsbeskatningen i Danmark og med inddragelse af fællesskabsretten. Værket belyser de forskellige skattemæssige konsekvenser af diverse civilretli...

Kolm keelt suus - sõlmes või selged? / Elo Odres

Index Scriptorium Estoniae

Odres, Elo, 1969-

2015-01-01

Eestlanna Elery ja itaallase Andrea Pellagatti pojad Aaron ja Lucas räägivad eesti, inglise ja itaalia keelt, eestlanna Signe ja rootslase Ingvar Rehbinderi tütar Iris-Mariel oskab eesti, rootsi, inglise ja hispaania keelt ning poeg Erik-William eesti ja rootsi keelt

Riigikogu liige ei vaja hooldusassistenti / Ignar Fjuk

Index Scriptorium Estoniae

Fjuk, Ignar, 1953-

2001-01-01

Ilmunud ka: Järva Teataja, 11. sept. 2001, lk. 2; Nädaline, 11. sept. 2001, lk. 4; Vooremaa, 11. sept. 2001, lk. 2; Võrumaa Teataja, 11. sept. 2001, lk. 2; Valgamaalane, 22. sept. 2001, lk. 2. Noorpoliitikud Keskerakonnast pöördusid Riigikogu poole ettepanekuga viia Eesti parlamendis sisse assitendi süsteem. Autor: Reformierakond. Parlamendisaadik

Kubilius conquers America / Rokas M. Tracevskis

Index Scriptorium Estoniae

Tracevskis, Rokas M.

2010-01-01

5.- 9. maini kestnud Ameerika Ühendriikide visiidi ajal kohtus Leedu peaminister Andrius Kubilius riigisekretäri Hillary Rodham Clintoniga, kellega räägiti riikidevahelistest suhetest, CIA salavanglast ja Egle Kusaitest, kes väidetavalt plaanis Venemaa sõjalistel objektidel läbi viia terrorirünnakud. Andrius Kubilius kohtus ka IBMi esindajatega. IBM plaanib rajada Leetu uurimiskeskuse

Peetri maja kant Kadriorus saab peagi uue näo / Ulvar Käärt

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2009-01-01

Kadrioru pargis asuva Peeter I maja ja presidendi kantselei vahelise pargiala uuendustöödest. Vt. samas: Presidendi lossi esine suletakse. Peetri aia rekonstrueerimistööde käigus on plaanis pargi territooriumile üle viia ka praegu presidendi kantselei esist paraadplatsi läbiv kõnnitee, kuna kantseleil on plaanis hoone esine ümbritseda piirdeaiaga

IMF soovitab uue töölepinguseaduse kiiresti vastu võtta / Peep Lillemägi

Index Scriptorium Estoniae

Lillemägi, Peep, 1967-

2008-01-01

Ilmunud ka: Tallinnskii Vestnik juuli 2008, lk. 3. Eestis viibinud IMF-i delegatsiooni hinnangul sõltub Eesti majanduskasvu taastumine suurel määral majanduse konkurentsivõimest, delegatsioon toetab kavatsust leida edasisi võimalusi kokkuhoiuks ning soovitab töölepinguseaduse eelnõu kiiresti vastu võtta ja ellu viia. Rahandusminister Ivari Padari arvamus IMF-i hinnangute kohta

Veel kord riigi poolsest teoprovokatsioonist : kas keelatud või siiski lubatud? / Paavo Randma

Index Scriptorium Estoniae

Randma, Paavo, 1977-

2006-01-01

Agent provocateur'i mõistest ja lubatavusest Inglismaa, Saksamaa ja Portugali kohtupraktika näitel. Agent provocateur on isik, kes politseiametniku või eraisikuna kriminaalmenetlust toimetavate asutuste ülesandel või heakskiidul kihutab teise isiku kuritegu toime panema eesmärgiga ta kinni võtta ja tema suhtes läbi viia kriminaalmenetlus, mis päädiks karistusega

Nam ljubõje dorogi dorogi / Sergei Kolikov

Index Scriptorium Estoniae

Kolikov, Sergei

2004-01-01

Tänavu on remonditakse Tallinn-Tartu maanteed 183 miljoni krooni eest, 60 kilomeetrise Tallinn-Peterburi maanteelõigu rekonstrueerimiseks määras Euroopa Komisjon küll 392 miljonit krooni, kuid töö lükkub järgmisse aastasse. Teetööde vähenemine võib mõned ettevõtted viia pankroti piirile

bladet. Acta Periodica Rerum Interiorum Bibliotecae Universitatis

DEFF Research Database (Denmark)

2007-01-01

Temanummer med billeder, interwievs og personaleberetninger om Syddansk Universitetsbiblioteks afdeling i Østergade i Odense 1968-2007. Redaktører m.m. Erik Hellerup Madsen og Søren Mogensen sammen med redaktørgruppen Projekt Fra Glemmebogen. Yderligere bidrag kan findes i Projekt Fra Glemmebogen....

Teaching Cognitive-Moral Development in College (A Generalist Approach).

Science.gov (United States)

Gross, Francis L., Jr.

1981-01-01

Outlines methods of teaching moral issues to undergraduate students using works of Lawrence Kohlberg, William Perry, Jr., Erik Erikson, and Elisabeth Kubler-Ross in conjunction with literary tests. Encourages comparative and illustrative studies of literature and film. Suggests student participation in cognitive and moral decision making of…

Hjemkomst til Homer

DEFF Research Database (Denmark)

Skyum-Nielsen, Erik

2015-01-01

Erik Skyum-Nielsen beskriver i sin artikel hvordan tre moderne danske forfattere, Bjørnvig, Nordbrandt og Rifbjerg, har henvist til og genbrugt de homeriske digte eller motiver herfra i deres digtning. Med udgangspunkt i Gérard Genettes overbegreb transtekstualitet viser Skyum-Nielsen os først...

COCKROACHES, PESTICIDE USE, AND CHILDREN'S PULMONARY FUNCTION IN AN ARID COMMUNITY

Science.gov (United States)

Cockroaches, pesticide use, and children's pulmonary function in an arid communityErik Svendsen1, Mary Ross1, Melissa Gonzales2, Debra Walsh1, Scott Rhoney1, Gina Terrill1, Lucas Neas11US EPA, Chapel Hill, NC; 2University of New MexicoThe El Paso Children's He...

Gewaskeuze beïnvloedt insectendiversiteit

NARCIS (Netherlands)

Poelman, E.H.

2009-01-01

Op 1 oktober 2008 promoveerde Erik Poelman aan Wageningen Universiteit op het proefschrift getiteld ‘Linking variation in plant defence to biodiversity at higher trophic levels: a multidisciplinary approach’. Het doel van dit onderzoeksproject was om te bepalen wat het effect is van variatie in de

Proceedings – Mathematical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Keywords. Scattering theory; quadratic Hamiltonians. Abstract. We study the notion of asymptotic velocity for a class of perturbed time-dependent quadratic Hamiltonians. In particular we give a sufficient condition for absolute continuity. Author Affiliations. Erik Skibsted1. Institut for Matematiske Fag and MaPhySto, Aarhus ...

77 FR 25538 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate

Science.gov (United States)

2012-04-30

... ERIK PAUL FURLER NICOLAS SILVAN FURRER GAJA MARIA FURRER JONAS KEVIN FURRER SACHA GABRIELLA GAGNON... CATHERINE MARIE MILNE NATASHA JANE MIN CHRIS SHIK MIN STEVE BAE MIZRACHI ELI HAIM MONTAGUE ALEXANDRE NICOLAS... CHRISTIAN MARTIN SYZ ISABEL SUSAN TAN CHUAN LIONG TAN WEI-EE BEVERLY [[Page 25544

Wheat stem rust in South Africa: Current status and future research ...

African Journals Online (AJOL)

. In South Africa, stem rust caused by Puccinia graminis Pers. f. sp. tritici. Eriks. & E. Henn. (Pgt) is an important disease of wheat. Records of stem rust occurrence in South Africa date back to the late 1720's, when it was first discovered in the ...

Evaluación del efecto de una técnica de relajación autógena sobre la actividad cardiovascular y muscular durante la vigilia y el sueño de pacientes con secuelas de esguince cervical /

OpenAIRE

Mateos Salgado, Erik Leonardo

2011-01-01

 tesis que para obtener el grado de Doctor en Psicología, presenta Erik Leonardo Mateos Salgado ; asesor Benjamín Domínguez Trejo. 123 páginas : diagramas. Doctorado en Psicología UNAM, Facultad de Psicología, 2011

CERN among the honours in the Geneva inter-company cross-country race

CERN Multimedia

Anaïs Schaeffer

2013-01-01

On 12 October, members of the CERN Running Club were yet again among the medals at the 33rd Cross Inter-Entreprises de Genève.   From left to right: Clément, Bastien, Olivier, Cédric, Erik and Mika. (Photo: Clément Bovet.) Teams comprising 3 to 4 runners from companies in the Geneva Canton competed in the 6-km race through the Parc des Evaux in Onex. Two of CERN’s teams made it into the medals in the Men’s category* -  Cédric, Mika, Guillaume and Clément came second, closely followed by their colleagues Olivier, Erik and Bastien, in third.  The next and last event of the year for the members of the Running Club will be the Escalade race, on 6-7 December. * The other categories are “Women” and “Mixed”. The full race results are available here and more photos from the event are available here.

Lapse õigused esiplaanile / Erik Salumäe

Index Scriptorium Estoniae

Salumäe, Erik, 1970-

2007-01-01

Lastekaitsest ja lastega töötamise õigusi piiravast seaduseelnõust. Ilmunud ka Valgamaalane 31. mai 2007, lk. 2 ; Elva Postipoiss 2. juuni 2007, lk. 4 ; Hiiu Leht 1. juuni 2007, lk. 2 ; Koit 31. mai 2007, lk. 6 ; Vooremaa 31. mai 2007, lk. 2 ; Lääne Elu 2. juuni 2007, lk. 2 ; Oma Saar 21. juuni 2007, lk. 5 ; Sakala 28. juuni 2007, lk. 2, pealkiri kujul: pedagoog ja lapsehoidja peavad olema puhta taustaga

Omavalitsusjuhid Riigikontrolli urgitsemist ei karda / Erik Kalda

Index Scriptorium Estoniae

Kalda, Erik, 1969-

2005-01-01

Ilmunud ka: Severnoje 18. märts lk. 1,4. Poberezhje Iisaku vallavanem Avo Kiir, Kohtla-Järve linnapea Jevgeni Solovjov, Narva linnavolikogu esimees Mihhail Stalnuhhin, Jõhvi linnapea Aavo Keerme, Ida-Viru omavalitsuste liidu tegevdirektor Urve Erikson ja Sillamäe volikogu esimees Valdek Murd kommenteerivad valitsuses heakskiidu leidnud Riigikontrolli volituste laiendamist

Läänemeresoome keeleatlas / Sven-Erik Soosaar

Index Scriptorium Estoniae

Soosaar, Sven-Erik

2007-01-01

Arvustus: Atlas Linguarum Fennicarum : ALFE. 2, Itämerensuomalainen kielikartasto = Läänemeresoome keeleatlas = Ostseefinnischer Sprachatlas = Lingvistitsheski atlas pribaltiisko-finskihh jazõkov / [päätoimittaja Tuomo Tuomi ; 2. osan vastaava toimittaja Tiit-Rein Viitso ; kartat: Anneli Hänninen ; saksankielinen käännös: Klaas Ph. Ruppel, venäjänkielinen käännös: Vladimir Rjagojev, Nina Zaitseva, vironkielinen käännös: Helmi Neetar]. - Helsinki : Suomalaisen kirjallisuuden seura : Kotimaisen kielten tutkimuskeskus, 2007

Reaktoriturgu valitseb Prantsuse emalõvi / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2006-01-01

Tuumareaktoreid tootva USA firma Westinghouse müümiseks korraldatud enampakkumise tulemustest. Jaapani konglomeraadist Toshibast, kes võitis enampakkumise. Prantsuse riigile kuuluvast tuumareaktorite tootjast Areva. Lisa: Areva poliitilistes tõmbetuultes

Maksuparadiisid peidavad 9 triljonit dollarit / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2011-01-01

Sajal suuremal Londoni börsifirmal on umbes 8500 offshore-tütarfirmat. Global Financial Integrity hinnangul kaotavad vaesed riigid igal aastal maksuparadiisidesse üle triljoni dollari eest tulu, seda on üle 10 korra rohkem neile antavast arenguabist, teistel hinnangutel on maksuparadiisidesse peidetud kokku 9 triljonit dollarit

Doominokivide kolin läheneb? / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2008-01-01

Läti Parex Banka ja Põhjamaade vanima investeerimispanga Carnegie probleemidest ja üleminek riigi kontrolli alla. Autori arvates tuleks kaaluda ideed tuua Eesti riigi reservid kodumaistesse kommertspankadesse

IPA kavandab endale uut tehast / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2005-01-01

Ettevõte Interconnect Product Assembly (IPA) alustas juhtmeköidiste valmistajana, kuid püüab keskenduda aina keerulisemate seadmete tootmisele. Tabel: Interconnect Product Assembly. Lisa: Tootmisjuhid lõid oma tehase

Uus metsaseadus tasakaalustab erinevad huvid / Erik Kosenkranius

Index Scriptorium Estoniae

Kosenkranius, Erik, 1970-

2006-01-01

Uue metsaseaduse eelnõu eesmärkidest ning rakendusalast. Sama ka Vooremaa 2. märts 2006, lk. 4 ; Nädaline 11. märts 2006, lk. 8 ; Harjumaa 21. märts 2006, lk. 6 ; Lääne Elu (Keskkonnaleht) 18. märts 2006, lk. 3 ; Tartu Postimees : Keskkonnaleht 22. märts 2006, lk. 2 ; Harjumaa 21. märts 2006, lk. 6 ; Virumaa Teataja : Roheline Maakond 23. märts 2006, lk. 4 ; Sakala : Viljandimaa Keskkond 5. mai 2006, lk. 2 ; Koit : Metsaleht 9. mai 2006, lk. 2 ; Võrumaa Teataja : Võrumaa Keskkonnaleht 25. mai 2006, lk. 2 ; Valgamaalane 11. mai 2006, lk. 4

Seadusega liiklus rahulikumaks / Erik Salumäe

Index Scriptorium Estoniae

Salumäe, Erik, 1970-

2008-01-01

Eesti liiklusest, liiklusõnnetustest ning liiklusjärelevalvest. Hoiatusmenetluse sisseviimisest ja karistuste karmistamisest. Ilmunud ka Hiiu Leht 21. nov. 2008, lk. 2 ; Sakala 21. nov. 2008, lk. 2, pealkiri kujul: Jänesemask ei päästa ; Põhjarannik 22. nov. 2008, lk. 6 ; Koit 25. nov. 2008, lk. 6 ; Nädaline 25. nov. 2008, lk. 4 ; Vooremaa 22. nov. 2008, lk. 2

25 kaadrit sekundis / Liis Auväärt

Index Scriptorium Estoniae

Auväärt, Liis

2009-01-01

Nukufilmis käib töö filmiga "Lisa Limone & Maroc Orange", režissöör Mait Laas, animaatorid Triin Sarapik-Kivi, Märt Kivi, operaator Ragnar Neljandi, nukumeistrid Heigo Eeriksoo, Taivo Müürsep, Ene Mellow ja Kreeta Käeri. Dekoratsioonimeistrid Mait Erik ja Roman Kuznetsov

Bouncing Back: Erikson, Maslow and Recovery from Divorce.

Science.gov (United States)

Charnofsky, Stan

Counseling for recovery from divorce may be significantly enhanced if a general model of emotional health/deficiency can be applied. This article introduces an amalgam of Erik Erikson's developmental stages and Abraham Maslow's motivational hierarchy as a means of understanding the rigors of marital dissolution. The paradigm promotes client…

Utilization of Forward Error Correction (FEC) Techniques With Extensible Markup Language (XML) Schema-Based Binary Compression (XSBC) Technology

Science.gov (United States)

2004-12-01

NY 7. Erik Chaum NUWC Newport, RI 8. David Bellino NPRI Newport, RI 9. Dick Nadolink NUWC Newport, RI 10. VADM Roger Bacon (Ret...Science Advisor Pearl Harbor, HI 16. LT Andrew Hurvitz, USN FNMOC Monterey, CA 17. ENS Darin Keeter, USN FNMOC Monterey, CA 18. CAPT David

Religious Studies: The Shaping of a Field and a Guide to Reference Resources.

Science.gov (United States)

Lippy, Charles H.

1992-01-01

Discusses the development of religious studies as an academic discipline. Examines the work of leading thinkers in the field, including anthropologists Sir James Fraser and Edward Burnett Taylor, sociologist Max Weber, and psychologist Erik Erikson. Identifies some of the many reference works that deal with religious studies. (SG)

Development of COS-SNP and HRM markers for cost efficient and reliable haplotype-based detection of Lr14a in durum wheat (Triticum durum Desf.)

Science.gov (United States)

Leaf rust (Puccinia triticina Eriks. & Henn.) is a major disease affecting durum wheat production. The Lr14a leaf rust resistant gene present in the durum wheat cv. Creso and its derivative Colosseo is one of the best characterized leaf rust resistance sources presently deployed in durum wheat breed...

Theories of Childhood: An Introduction to Dewey, Montessori, Erikson, Piaget & Vygotsky, Second Edition

Science.gov (United States)

Mooney, Carol Garhart

2013-01-01

This best-selling resource provides clear, straightforward introductions to the foundational theories of John Dewey, Maria Montessori, Erik Erikson, Jean Piaget, and Lev Vygotsky. Each chapter highlights a theorist's work and includes insight on how the theory impacts teaching young children today. Discussion questions and suggested readings are…

Combining Performance and Flexibility for RMS with a Hybrid Architecture

NARCIS (Netherlands)

Dennis Koole; Arjan Groenewegen; Daniël Telgen; Patrick Wit; Leo van Moergestel; Arjan van Zanten; John-Jules Meyer; Ing. Erik Puik; Dick van der Steen; Pascal Muller

2013-01-01

Author supplied Combining Performance and Flexibility for RMS with a Hybrid Architecture Dani¨el Telgen 12? , Leo van Moergestel 1 , Erik Puik 1 , Pascal Muller 1 , Arjan Groenewegen 1 , Dick van der Steen 1 , Dennis Koole 1 , Patrick de Wit 1 , Arjen van Zanten 1 , and John-Jules

Efficient Training Methods for Conditional Random Fields

Science.gov (United States)

2008-02-01

Learning (ICML), 2007. [63] Bruce G. Lindsay. Composite likelihood methods. Contemporary Mathematics, pages 221–239, 1988. 189 [64] Yan Liu, Jaime ...Conference on Machine Learning (ICML), pages 737–744, 2005. [107] Erik F. Tjong Kim Sang and Sabine Buchholz. Introduction to the CoNLL-2000 shared task

Tarkvaraaudit säästab aega ja raha / Asso Puidet

Index Scriptorium Estoniae

Puidet, Asso, 1977-

2005-01-01

Tarkvaraaudit on osa tarkvarahaldusest, mis annab ülevaate ettevõttes olevast tarkvarast, olemasolevatest litsentsidest ja nende omavahelisest vastavusest. BSA Eesti Komitee tegevuse koordinaator Erik Mandre ja ITEX Consulting juhatuse esimees Ion Alender tarkvaraauditi teenust pakkuvatest ettevõtetest Eestis. Lisa: Audit annab vastused järgmistele küsimustele

Functional Analysis: Entering Hilbert Space

DEFF Research Database (Denmark)

Hansen, Vagn Lundsgaard

in a new chapter on Fredholm theory (Chapter 6). Fredholm theory originates in pioneering work of the Swedish mathematician Erik Ivar Fred-holm on integral equations, which inspired the study of a new class of bounded linear operators, known as Fredholm operators. Chapter 6 presents the basic elements...

Barriers to the widespread take-up of standardised e-learning

NARCIS (Netherlands)

Koper, Rob

2004-01-01

Introduction to the panel discussion at the Online Educa Berlin, December 2, 2004.
Members of the discussion panel:
Prof. Erik Duval, KUL, Belgium
Dr. Dexter Fletcher, ADL. USA
Prof. Oleg Liber, CETIS, Bolton, UK
Dr. Colin Tattersall, OUNL, The Netherlands
Prof. Rob Koper,

Selskabsret

DEFF Research Database (Denmark)

Werlauff, Erik

Erik Werlauffs klassiker i en ny, opdateret, 7. udgave. Bogen giver en udførlig gennemgang af retsforholdene for erhvervsdrivende juridiske personer. Selskaber og andre juridiske personer følges gennem alle relevante faser: Valg af retsform; stiftelse; kapitalforhold; ledelse; sammenlægning og ov...

Identification and validation of single nucleotide polymorphic markers linked to Ug99 stem rust resistance in spring wheat

Science.gov (United States)

Wheat stem rust (Puccinia graminis f. sp. tritici Eriks. and E. Henn.) is one of the most destructive diseases world-wide. Races belonging to Ug99 (or TTKSK) continue to cause crop losses in East Africa and threaten global wheat production. Developing and deploying wheat varieties with multiple race...

Genetic mapping of stem rust resistance to Puccinia graminis f. sp. tritici race TRTTF in the Canadian wheat cultivar 'Harvest'

Science.gov (United States)

Stem rust, caused by Puccinia graminis Pers.:Pers. f. sp. tritici Eriks. & E. Henn.(Pgt), is a destructive disease of wheat that can be controlled by deploying effective stem rust resistance (Sr) genes. Highly virulent races of Pgt in Africa have been detected and characterized. These include race T...

Royal Murders in the Danish Middle Ages

DEFF Research Database (Denmark)

Petersen, Nils Holger

2017-01-01

Liner notes for an audio recording of music in medieval Denmark, including chants from the office of St Knud Lavard, martyred in 1131, and songs by Meister Rumelant about the murder of King Erik V "Klipping" (1286). The essay gives historical information about the murders and their later musical...

Design your kitchen versus kitchen design / Ontwerp je keuken versus keukenontwerp

DEFF Research Database (Denmark)

Baumeister, Ruth

2016-01-01

This article presents two kitchen designs from the immediate post-war period - one by Swiss French architect Le Corbusier and the other by the Danish artists Asger Jorn and Erik Nyholm. These two works present a different understanding of the hegemony of design and designer versus the user. Both...

Zn Electrodeposition on Single-Crystal GaN(0001 Surface: Nucleation and Growth Mechanism

Directory of Open Access Journals (Sweden)

Fei Peng

2016-01-01

Full Text Available The electrochemical deposition of zinc on single-crystal n-type GaN(0001 from a sulphate solution has been investigated on the basis of electrochemical techniques including cyclic voltammetry, chronoamperometry, and Tafel plot. The morphology and crystal structure of zinc deposits have been characterized by means of scanning electron microscopy, X-ray diffraction, and energy-dispersive X-ray analysis. The result has revealed that the deposition of Zn on GaN electrode commenced at a potential of −1.12 V versus Ag/AgCl. According to the Tafel plot, an exchange current density of ~0.132 mA cm−2 was calculated. In addition, the current transient measurements have shown that Zn deposition process followed the instantaneous nucleation in 10 mM ZnSO4 + 0.5 M Na2SO4 + 0.5 M H3BO3 (pH = 4.

Metoodika lapse emotsionaalse väärkohtlemise hindamiseks institutsionaalses keskkonnas / Triin Edovald

Index Scriptorium Estoniae

Edovald, Triin

2001-01-01

Uurimusest, mille eesmärgiks oli lapse emotsionaalse väärkohtlemise hindamise metoodika kohandamine lastekodu tingimustele. Uurimus viidi läbi ühes Tartu lastekodus, intervjueerides kuut kasvatajat ja vaadeldes kuue lastekodulapse ja tema usalduskasvataja vahelist suhtlemist ja tegevust eesmärgiga sisse viia võimalikud täpsustused ja muutused emotsionaalse väärkohtlemise hindamise metoodikasse kohandades seda lastekodu tingimustele

Mõeldes arhitektuuri välkloengutele = Considering flash lectures on architecture / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

7. veebruaril 2008 Von Krahli Teatris alanud arhitektuuri välkloengutest, mille eesmärk oli haarata avalikkust kaasa mõtlema, rääkima meid ümbritsevast keskkonnast ning viia ühiskonda arusaamist, et arhitektuur on meie kõigi asi. Arhitektuurist kutsuti rääkima tuntud äri- ja kultuuriinimesi. Välkloenguid modereerisid Ülar Mark, Margit Mutso ja Mattias Agabus

Rohkem kui 300 aastat tagasi surnud pere õnnestus tuvastada / Mati Mandel ; Kalev Jaago

Index Scriptorium Estoniae

Mandel, Mati, 1945-

2016-01-01

Peanse külas Lihula vallas toimunud kaevamistest. Leiti nelja inimese luustikud. Leiumaterjal võimaldas võrrelda ja kokku viia arheoloogi, numismaatiku, atropoloogi ja arhivaari uurimistulemusi. Suure tõenäosusega võisid leitud maetud olla Leti Andrese Mihkel, tema abikaasa ning lapsed Heinrich ja Ann. Tegu võib olla 1710.- 1711. aasta katku ohvritega. Haruldase juhtumina saab luid seostada konkreetsete ajalooliste isikutega

Euroopa Liit valmistab ette uutmoodi Venemaa-poliitikat / Ahto Lobjakas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2006-01-01

EL-i järgmine eesistujariik Saksamaa pakub täielikku paradigma muutust EL-i ja Venemaa suhetes, autori sõnul asenduks senine rõhk "ühistel väärtustel" huvide kaine kalkulatsiooniga. Autor esitab oma seisukoha, kuidas peaks toimima Eesti: probleemid Venemaaga on vaja viia miinimumini ning EL-is tuleb toetada ühiseid valikuid vetoõiguse ja erahuvide vastu

Kuidas valiti president 1996. aastal? / Rein Toomla

Index Scriptorium Estoniae

Toomla, Rein, 1951-

2002-01-01

Autor leiab 1996. aasta presidendivalimisi analüüsides, et oluliseks tuleb pidada seda, et valimised suudeti põhiseaduses ettenähtud korras läbi viia ning ei pidanud käivituma erakorraliste valimiste mehhanism. Tabelid: 1995. a. Riigikogu valimised; Riigikogu fraktsioonid 1996. a. suvel; Toetus presidendikandidaatidele; Presidendivalimised Riigikogus; Arvatavasti Lennart Meri poolt; Arvatavasti Arnold Rüütli poolt; Presidendivalimised Valimiskogus

Euroopa hing / Joseph Ratzinger ; tõlk. Külli-Riin Tigasson

Index Scriptorium Estoniae

Ratzinger, Joseph

2005-01-01

Paavst Benedictus XVI sõnul võib moraalsete väärtuste purunemine viia Euroopa identiteedi enesehävitamiseni. Inimväärikusest ja inimõigustest peab kujunema tingimusteta väärtus, ka on Euroopa identiteedi jaoks keskne tähtsus abielul ja perekonnal. Sõnavabadusel peab olema piir: teise inimese au ega väärikust ei tohi haavata

Using RNA-sequencing and in silico subtraction to identify resistance gene analog markers for Lr16 in wheat

Science.gov (United States)

Leaf rust, caused by Puccinia triticina Eriks., is one of the most widespread diseases of wheat worldwide and breeding for resistance is one of the most effective methods of control. Lr16 is a wheat leaf rust resistance gene that provides resistance at both the seedling and adult stages. Simple s...

Affective Education: A Teacher's Manual to Promote Student Self-Actualization and Human Relations Skills.

Science.gov (United States)

Snyder, Thomas R.

This teacher's manual presents affective education as a program to promote student self-actualization and human relations skills. Abraham Maslow's hierarchy of needs and Erik Erikson's life stages of psychosocial development form the conceptual base for this program. The goals and objectives of this manual are concerned with problem-solving…

75 FR 22150 - Certificate of Alternative Compliance for the Ferry Boat CHARLEVOIX

Science.gov (United States)

2010-04-27

... INFORMATION CONTACT: If you have questions on this notice, call LCDR Wm. Erik Pickering, District Nine, Prevention Branch, U.S. Coast Guard, telephone 216-902-6050. If you have questions on viewing or submitting... CHARLEVOIX. Full compliance with 72 COLREGS and the Inland Rules Act would hinder the vessel's ability to...

Autokool kahtlustab ARK-i kättemaksus / Antti Oolo

Index Scriptorium Estoniae

Oolo, Antti, 1967-

2000-01-01

Tallinna autokooli Radial omanik Peeter Erik näeb kooli võimaliku tegevuslitsentsist ilmajäämise taga riikliku autoregistrikeskuse kättemaksu. Veebruaris jäi Radiali töötaja Meeli Kaljusaar kaitsepolitseile vahele ebaseaduslikult väljastatud juhilubade müügiga. Tabel: Litsentsi kaotamise ohus olevad autokoolid

Pistise andmine mainet eriti ei kahjusta / Aleksei Günter

Index Scriptorium Estoniae

Günter, Aleksei, 1979-

2005-01-01

Sotsiaalministeeriumi IT-juhile Henry Timmermanile pistist ja altkäemaksu andnud seitse IT-ärimeest pääsesid kriminaalmenetlusest, kuna nad tunnistasid oma seadusvastaseid tegusid ning aitasid kaasa tehingute detailide päevavalgele toomisele. Lisad: Erik Tambaur; Tarvi Tara; Sten Soosaar; Janek Karu; Toomas Perillus; Karel Kannel; Andreas Simsel

Kirjad Sirbile / Mart Kivastik

Index Scriptorium Estoniae

Kivastik, Mart, 1963-

2007-01-01

Mannheimi filmifestivalist. Filmidest "Nadine" (rezh. Erik de Bruyn), "Dead End", "Kremen" (rezh. Aleksei Mizgirev), "Overnight" (rezh. Ferenc Török), "Mirush" ("Blodsband", rezh. Marius Holst), "Sztuczki" (rezh. Andrzej Jakimowski), "Por sus propios ojos" ("Through her own eyes", rezh. Liliana Paolinelli), "Terra Sonambula" ("Sleepwalking Land", rezh. Teresa Prata). Festivali auhinnatud filmid

Viewing Generativity and Social Capital as Underlying Factors of Parent Involvement

Science.gov (United States)

Stevens, Sharon; Patel, Nimisha

2015-01-01

Parent involvement in education is a multifaceted support that has many well-documented benefits for students of all ages. Parent involvement is also a common expression of generativity as defined in Erik Erikson's theory of psychosocial development. The activities parents engage in during their children's educational pursuits, as well as their…

Man-Induced Vibrations

DEFF Research Database (Denmark)

Jönsson, Jeppe; Hansen, Lars Pilegaard

1994-01-01

work has been done on the measurement of the exact load functions and related reponse analysis. A recent work using a spectral description has been performed by Per-Erik Erikson and includes a good literature survey. Bachmann and Ammann give a good overview of vibrations caused by human activity. Other...

Romaanid ja trend / Teet Kallas

Index Scriptorium Estoniae

Kallas, Teet, 1943-

2003-01-01

Romaanivõistluse parimatest: Nikolai Baturini "Kentaur", Indrek Hargla "Vabaduse kõrgeim määr" ja Enn Põldroosi "Joonik kivi"; ka äramärgitud töödest: Sass Henno "Elu algab täna", Agu Tammeveski "Kas teie olite siis teistsugune?" ja Erik Tohvri "Tants läbi rukki"

Embodying Alternatives to Capitalism in the 21st Century

DEFF Research Database (Denmark)

Monticelli, Lara

2018-01-01

that are “interstitial”, i.e. initiatives that are developing within capitalism and are striving to prefigure a post-capitalist society in the here and now without engaging in contentious, violent and revolutionary actions and activities. To achieve this, I mainly focus on the work of four authors: Erik Olin Wright...

Molecular and cytogenetic characterization of wheat introgression lines carrying the stem rust resistance gene Sr39.

Science.gov (United States)

Stem rust, caused by Puccinia graminis Pers.:Pers. f.sp. tritici Eriks. and Henn., poses a serious threat to global wheat production because of the emergence of Pgt-TTKSK (Ug99). The TTKSK resistant gene Sr39 was derived from Aegilops speltoides through chromosome translocation. In this study, we ch...

The Question of Work: Adolescent Literature and the Eriksonian Paradigm.

Science.gov (United States)

Burgan, Mary

1988-01-01

Suggests that focusing on paradigms of work--the way it is described, together with the thematic implications it embodies--can be useful in teaching literature to young adults. Examines how examples from literature illustrate Erik H. Erikson's paradigm of the psychosocial stages of development in late childhood and adolescence. (MM)

Gifted Children and Erikson's Theory of Psychosocial Development.

Science.gov (United States)

Cross, Tracy L.

2001-01-01

After presenting an overview of Erik Erikson's theory of psychosocial development, the theory is applied to the development of gifted children. The psychosocial crisis experienced by children when they are infants, toddlers, preschoolers, elementary-aged, and during adolescence are examined, along with ways parents and teachers can help at each…

A Developmental Model Applied to Problems of Deafness.

Science.gov (United States)

Schlesinger, Hilde S.

2000-01-01

This "classic" article (1972) in the field of deaf studies includes some interpretive notes for current readers. The article examines the effect of deafness on basic developmental tasks at each of the eight developmental stages of Erik Erikson's theory of psychosocial development and explains the more successful passage through these…

Daylight as a building material

DEFF Research Database (Denmark)

Thule Kristensen, Peter; Madsen, Merete

2005-01-01

The article draws on examples to chronologically trace the use of daylight as building material in architecture of the 20th and early 21st century. The essay covers works of Mies van der Rohe, Le Corbusier, Erik Bryggman, Rudolf Schwarz, Alvar Aalto, Aldo Rossi, Jørn Utzon, Daniel Libeskind, Peter...

Theoretical Chemistry and Electrochemistry

Indian Academy of Sciences (India)

Administrator

Faradaic rectification; (ii) effect of diffuse double layer on electrode kinetics; (iii) accel- erated Tafel plots for ... NAL during 1970–1975, Rangarajan embarked upon developing a Systems Analysis approach to all ... chemical systems, mechanism of electrochemical crystallization, adsorption isotherms at electrode surfaces ...

Enhancement of the efficacy of therapeutic proteins by formulation with PEGylated liposomes; a case of FVIII, FVIIa and G-CSF.

Science.gov (United States)

Yatuv, Rivka; Robinson, Micah; Dayan, Inbal; Baru, Moshe

2010-02-01

Improving the pharmacodynamics of protein drugs has the potential to improve the care and the quality of life of patients suffering from a variety of diseases. Four approaches to improve protein drugs are described: PEGylation, amino acid substitution, fusion to carrier proteins and encapsulation. A new platform technology based on the binding of proteins/peptides to the outer surface of PEGylated liposomes (PEGLip) is then presented. Binding of proteins to PEGLip is non-covalent, highly specific and dependent on an amino acid consensus sequence within the proteins. Association of proteins with PEGLip results in substantial enhancement of the pharmacodynamic properties of proteins following administration. This has been demonstrated in preclinical studies and clinical trials with coagulation factors VIII and VIIa. It has also been demonstrated in preclinical studies with granulocyte colony-stimulating factor. A mechanism is presented that explains the improvements in hemostatic efficacy of PEGLip-formulated coagulation factors VIII and VIIa. The reader will gain an understanding of the advantages and disadvantages of each of the approaches discussed. PEGLip formulation is an important new approach to improve the pharmacodynamics of protein drugs. This approach may be applied to further therapeutic proteins in the future.

Status of stellarator research

International Nuclear Information System (INIS)

Wobig, H.

1985-01-01

In recent years main activities in stellarator research were focussed on production and investigation of currentless plasmas. Several heating methods have been applied: electron cyclotron heating, ion cyclotron heating and neutral beam injection. The parameters achieved in HELIOTRON E and W VII-A are: antin 20 m 3 , Tsub(i) <= 1 keV. The confinement is improved as compared with ohmically heated discharges. By ECRH (P = 200 kW) it is possible to heat electrons up to 1.4 keV, confinement in this regime is dominated already by trapped particle effects. Toroidal currents up to 2 kA - either bootstrap currents or externally driven currents - were observed. High β-values (antiβ = 2%) have been obtained in HELIOTRON E, in this regime already pressure driven MHD-modes were observed. Future experiments (ATF-1 and W VII-AS) will extend the parameter regime to temperatures of several keV. These experiments will give important information about critical problems of the stellarator line (β-limit, neoclassical confinement impurity transport). A few reactor studies of stellarators exist, attention is mainly concentrated on technical problems of the modular coil system

Early Learning Theories Made Visible

Science.gov (United States)

Beloglovsky, Miriam; Daly, Lisa

2015-01-01

Go beyond reading about early learning theories and see what they look like in action in modern programs and teacher practices. With classroom vignettes and colorful photographs, this book makes the works of Jean Piaget, Erik Erikson, Lev Vygotsky, Abraham Maslow, John Dewey, Howard Gardner, and Louise Derman-Sparks visible, accessible, and easier…

76 FR 36138 - Certificate of Alternative Compliance for the Passenger Vessel CHICAGO'S LEADING LADY

Science.gov (United States)

2011-06-21

... CONTACT: If you have questions on this notice, call LCDR Wm. Erik Pickering, District Nine, Prevention Branch, U.S. Coast Guard, telephone 216-902-6050. If you have questions on viewing or submitting material... as high as required for full compliance with Annex I of the Inland Rules Act. The Commandant, U.S...

"Play" across the Life Cycle: From Initiative to Integrity to Transcendence

Science.gov (United States)

Jones, Elizabeth

2011-01-01

In this autobiographical journey through life-span developmental theory, the author reflects on her life as a player, embedding it in the context of Erik Erikson and Joan Erikson's stages of human development. The author builds on these basic ideas--theory, storytelling, play, and development--and defines them as simply as possible.

Fellowship of "Fate" and Fellowships of "Faith": Religious Education and Citizenship Education in Europe

Science.gov (United States)

Roebben, Bert

2008-01-01

In this paper the relationship between religious identity and engagement in citizenship is examined from an educational point of view. The Dutch systematic theologian Erik Borgman refers to the development of European citizenship as a project of "fellowship of fate": we will need to rediscover a common vision on humanity for Europe as…

A Paediatrician Looks at Traditional Approaches to Emotional Development in Preschool and Primary Years. Foundation for Child and Youth Studies Selected Papers Number 46.

Science.gov (United States)

Phillips, Susi Erika

This discussion of the emotional development of young children is structured upon Erik Erikson's schemata of psycho-social development. Stage 1, which involves trust versus mistrust, includes references to Erikson's theory and the work of Melanie Klein, Berry Brazelton, Stella Chess and Alexander Thomas, John Bowlby, Anthony Stevens, and D. W.…

"They're Listening"; A Report on a Psychosocial Approach to Teaching.

Science.gov (United States)

Boyd, Robert D.; And Others

This monograph reports on a project designed to help teachers use Erik Erikson's concept of ego psychology as a framework to help students with school-related difficulties. It was hypothesized that a full understanding of the growth patterns of students, their orientation to their social (school and family) environment, and the development of…

Fim da era constantiniana: Retrospectiva genealógica de um conceito crítico

Directory of Open Access Journals (Sweden)

Sebastian Pedro Pattin

2015-09-01

Full Text Available El presente documento es una reseña de la obra del Dr. Zamagni, historiador de los conceptos religiosos, referida al "fin de la era constantiniana" a través del analisis de Marie-Dominique Chenu, Friedrich Heer, Étienne Gilson, Emmanuel Mounier, Jacques Maritain, Ernesto Buonaiuti y Erik Peterson.

Bereavement: Applying Erikson's Theory of Psychosocial Development to College Students.

Science.gov (United States)

Floerchinger, Debra S.

One of the developmental challenges that a college student may have to face is the death of a significant other, friend, spouse, relative, child, or parent. This article reviews the literature on the potential effects of bereavement on a college student with respect to Erik Erikson's stage six of psychosocial development (intimacy versus…

The Implications of Psychosocial Theory for Personal Growth in the Family.

Science.gov (United States)

Newman, Philip R.; Newman, Barbara M.

Psychosocial theory, based on the ideas of Erik Erikson and Robert Havighurst, is proposed as a useful framework for conceptualizing the potential for growth within the family. Erikson's (1950) eight stage theory of psychosocial development and Havighurst's (1959) concept of developmental tasks are used to take account of the stages of development…

Workshop #7 Toentje: Stakeholder Canvas

NARCIS (Netherlands)

Levelt, M.

2017-01-01

Op vrijdag 19 mei vond alweer de zevende R-LINK Workshop plaats tijdens de driedaagse in Groningen. In de voormalige drankenfabriek van de Firma Woldring en Idema aan de Paradijsvogelstraat zaten onderzoekers samen met betrokkenen van Toentje, Bie de Buuf en de Oosterparkwijk om tafel in

Kinetics of hydrogen evolution reaction on Zr0⋅5Ti0⋅5V0⋅6Cr0 ...

Indian Academy of Sciences (India)

Unknown

The corrosion–current density measured from Tafel polarization of ORR is found to ... potential of the electrode is shifted to about – 0⋅93 V vs Hg/HgO, OH–, which ... The impedance data are analyzed by a non-linear least square curve fitting ...

Multilayer graphene as an effective corrosion protection coating for copper

Science.gov (United States)

Ravishankar, Vasumathy; Ramaprabhu, S.; Jaiswal, Manu

2018-04-01

Graphene grown by chemical vapor deposition (CVD) has been studied as a protective layer against corrosion of copper. The layer number dependence on the protective nature of graphene has been investigated using techniques such as Tafel analysis and Electroimpedance Spectroscopy. Multiple layers of graphene were achieved by wet transfer above CVD grown graphene. Though this might cause grain boundaries, the sites where corrosion is initiated, to be staggered, wet transfer inherently carries the disadvantage of tearing of graphene, as confirmed by Raman spectroscopy measurements. However, Electroimpedance Spectroscopy (EIS) reflects that graphene protected copper has a layer dependent resistance to corrosion. Decrease in corrosion current (Icorr) for graphene protected copper is presented. There is only small dependence of corrosion current on the layer number, Tafel plots clearly indicate passivation in the presence of graphene, whether it be single layer or multiple layers. Notwithstanding the crystallite size, defect free layers of graphene with staggered grain boundaries combined with passivation could offer good corrosion protection for metals.

Corrosion behaviour of 6063 aluminium alloy in acidic and in alkaline media

Directory of Open Access Journals (Sweden)

Prabhu Deepa

2017-05-01

Full Text Available The corrosion behaviour of 6063 aluminium alloy was investigated in different concentrations of phosphoric acid medium and sodium hydroxide medium at different temperatures. The study was done by electrochemical method, using Tafel polarization technique and electrochemical impedance spectroscopy (EIS technique. The surface morphology was investigated using scanning electron microscope (SEM with Energy-dispersive X-ray spectroscopy (EDX. The results showed that the 6063 aluminium alloy undergoes severe corrosion in sodium hydroxide medium than in phosphoric acid medium. The corrosion rate of 6063 aluminium alloy increased with an increase in the concentration of acid as well as with alkali. The corrosion rate was increased with an increase in temperature. The kinetic parameters and thermodynamic parameters were calculated using Arrhenius theory and transition state theory. Suitable mechanism was proposed for the corrosion of 6063 aluminium alloy in phosphoric acid medium and sodium hydroxide medium. The results obtained by Tafel polarization and electrochemical impedance spectroscopy (EIS techniques were in good agreement with each other.

Modeling the Electrochemical Hydrogen Oxidation and Evolution Reactions on the Basis of Density Functional Theory Calculations

DEFF Research Database (Denmark)

Skulason, Egill; Tripkovic, Vladimir; Björketun, Mårten

2010-01-01

charged Pt(111) slab and solvated protons in up to three water bilayers is considered and reaction energies and activation barriers are determined by using a newly developed computational scheme where the potential can be kept constant during a charge transfer reaction. We determine the rate limiting...... reaction on Pt(111) to be Tafel−Volmer for HOR and Volmer−Tafel for HER. Calculated rates agree well with experimental data. Both the H adsorption energy and the energy barrier for the Tafel reaction are then calculated for a range of metal electrodes, including Au, Ag, Cu, Pt, Pd, Ni, Ir, Rh, Co, Ru, Re......, W, Mo, and Nb, different facets, and step of surfaces. We compare the results for different facets of the Pt electrode to experimental data. Our results suggest that the most important parameter for describing the HOR or the HER activity of an electrode is its binding free energy of H. We present...

Corrosion behavior of low-alloy steel in the presence of Desulfotomaculum sp

International Nuclear Information System (INIS)

Cetin, Demet; Aksu, Mehmet Levent

2009-01-01

The objective of this study was to determine the effect of sulfate-reducing Desulfotomaculum sp. bacteria isolated from a crude oil field on the corrosion of low-alloy steel. The corrosion rate and mechanism were determined with the use of Tafel slopes, mass loss method and electrochemical impedance spectroscopy (EIS). The formation of the biofilm and the corrosion products on the steel surface was determined with scanning electron microscopy (SEM) micrographs and energy dispersive X-ray spectra (EDS) analysis. It was observed from the Tafel plots that the corrosion potential exhibited a cathodic shift that verifies an increase in the corrosion rates. The semicircles tended to open at lower frequencies in the Nyquist plots which indicates the rupture of the protective film. The corrosion current density reached its maximum value at the 14th hour after the inoculation and decreased afterwards. This was attributed to the accumulation of corrosion products on the surface.

In-Situ Electrochemical Corrosion Behavior of Nickel-Base 718 Alloy Under Various CO2 Partial Pressures at 150 and 205 °C in NaCl Solution

Science.gov (United States)

Zhang, Yubi; Zhao, Yongtao; Tang, An; Yang, Wenjie; Li, Enzuo

2018-03-01

The electrochemical corrosion behavior of nickel-base alloy 718 was investigated using electrochemical impedance spectroscopy and potentiodynamic polarization techniques at various partial pressures of CO2 (P_{{{CO}2 }} s) in a 25 wt% NaCl solution at 150 and 205 °C. The passive films composed of FeCO3 exhibit good corrosion resistance with a feature of Warburg impedance, Tafel plots show a complete passivation and the anodic reactions was dominated by a diffusion process at low P_{{{CO}2 }} s (1.8-9.8 MPa) at 150 °C. While numerous dented corrosion areas appeared on the sample surface for the P_{{{CO}2 }} of 11.6 MPa at 205 °C, the Tafel plot with three anodic peaks and the Nyquist diagram with an atrophied impedance arc were present. This dented corrosion attribute to the synergistic effects of stress, temperature, P_{{{CO}2 }} and Cl-, the temperature and stress could play crucial roles on the corrosion of the alloy 718.

Two Water Stable Copper Metal-Organic Frameworks with Performance in the Electrocatalytic Activity for Water Oxidation

Directory of Open Access Journals (Sweden)

Liu Xiuping

2018-01-01

Full Text Available Two novel water stable metal-organic frameworks, [Cu(L·(4,4′-bipy·(ClO4]n (1, [Cu(L·(phen·(ClO4·(H2O]2 (2, have been constructed by HL=[5-Mercapto-1-methyl] tetrazole acetic acid and Cu (II salt in the presence of assistant N-containing ligands. MOF 1 and MOF 2 with open CuII sites, resulting the framework 1 and 2 show electrocatalytic activity for water oxidation in alkaline solution. The electrochemical properties of complex for oxygen evolution reaction (OER were evaluated by linear sweep voltammetry (LSV and the Tafel slopes. Complex 1 has a higher LSV activity with a lower over potential of 1.54 V and a much higher increase in current density. Meanwhile, the Tafel slope of complex 1 (122.0 mV dec-1 is much lower than complex 2 (243.5 mV dec-1. This phenomenon makes complex 1 a promising porous material for electrocatalytic activity.

Kodanikud, võltsingud ja zombid / Tanel Tammet

Index Scriptorium Estoniae

Tammet, Tanel

2005-01-01

Autor avaldab arvamust, et e-valimiste vastu olevad erakonnad ja poliitikud pole mures mitte niivõrd nende valimiste turvalisuse pärast, vaid pigem seepärast, et e-valimised võivad suurendada noorema valijaskonna aktiivsust. E-valimiste õnnestumine võib viia mõttele Šveitsi otsedemokraatia mõne põhimõtte rakendamise kohta Eestis. Autor kirjeldab turvariske, mis võivad kaasneda e-valimistel

Valitsuse stabiilsus Eestis : soovunelm või tegelikkus? / Olaf Dahlmann

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Dahlmann, Olaf

2003-01-01

Autor leiab, et hoolimata sagedastest valitsuste vahetumistest, pingetest sisepoliitikas ja rahva üha süvenevast poliitilisest apaatsusest, on Eesti suutnud edukalt läbi viia poliitilisi reforme. Üldine konsensus põhilistes küsimustes on peamiste poliitiliste eesmärkide ja reformipoliitika püsivuse alus, seega ka ka valitsuse stabiilsuse alus. Tabel: Eesti valitsused alates 1992. aastast. Joonis: Valitsuse stabiilsust mõjutavad tegurid

Me ei tohi peatuda / Harri Õunapuu

Index Scriptorium Estoniae

Õunapuu, Harri, 1947-

2006-01-01

Ilmunud ka: Põhjarannik, Severnoje Poberezhje 3. mai lk. 2, Nädaline, Võrumaa Teataja, Vooremaa 4. mai lk. 3,2,2, Harjumaa 5. mai lk. 2, Meie Maa 6. mai lk. 2, Hiiu Leht 9. mai lk. 2, Valgamaalane 16. mai lk. 2, Sakala 24. mai lk. 2. Autori sõnul on Reformierakonna poolt seatud eesmärk viia Eesti viie jõukama riigi sekka Euroopas saavutatav

Eesti gaasiküsimustes : õnnis nagu palderjani nuusutanud kass / Virkko Lepassalu

Index Scriptorium Estoniae

Lepassalu, Virkko, 1971-

2008-01-01

Kehtiva Euroopa Liidu nn gaasidirektiivi 55/2003 järgi soovitatakse gaasi tootmine ja levitamine viia eraldi ettevõtete kätte, praegu ettevalmistatav regulatsioon muudaks selle kohustuslikuks. Seega peaks Gazprom oma 37% -lise osaluse Eesti Gaasis maha müüma. Eesti Gaasi kui sisulise monopolisti hoidmine Gazpromi filiaalina Eestis ohustab otseselt meie julgeolekut. Vt. samas: Välisminister Urmas Paeti kiri Nord Streamile; Nord Streami kaanepoisid

Nähtamatu naise nähtav panus / Eerik Purje ; fotod: V. Sarapuu

Index Scriptorium Estoniae

Purje, Eerik, 1927-

2006-01-01

17. oktoobri õhtul Tartu College´i saalis toimunud pidulikust õhtust, mis oli pühendatud Vaiki Toile, esitades Roman Toi loomingut ja tähistades Romani 90. sünnipäeva. Õhtut juhtis Avo Kittask, esinesid Estonia Koor, Toronto Eesti Meeskoor, lauluansambel Helin, klaveril saatis Asta Ballstadt, koore juhatasid Margit Viia-Maiste, Ingrid Silm, Charles Kipper. Avati kunstnik Josef Milczarski portree juubilarist

Tarla Tarımı Yapılan Toprakların Meyve Yetiştiriciliğine Uygunluğunun Araştırılması: Yeşilsırt Köyü Örneği

Directory of Open Access Journals (Sweden)

Korkmaz BELLİTÜRK

2014-09-01

Full Text Available Yeşilsırt, Tekirdağ ilinin Muratlı ilçesine bağlı bir köydür. Ekonomisi tarım ve hayvancılığa dayanan köyde daha çok buğday ve ayçiçeği ekiminde kullanılan tarım arazilerinde meyvecilik, ilçe merkezinde olduğu gibi çok küçük bir paya sahiptir. İklim özellikleri bakımından meyve yetiştiriciliğine uygun olan ve sulama suyu sıkıntısı olmayan bu bölgenin buğday ve ayçiçeği ekimi yapılan tarım alanlarından alınan 26 adet toprak örneğinin fiziksel ve kimyasal özellikleri değerlendirilerek, bu toprakların meyveciliğe uygun olup olmadığı sorgulanmıştır. Analiz sonuçlarına göre, toprakların pH değerleri elma, armut, erik ve kiraz yetiştirilmesi için uygundur. Fosfor, demir ve bakır bakımından iyi durumda olan topraklarda azot eksikliği mevcuttur. Toprakların yarısından fazlasında potasyum, mangan ve çinko eksikliği olduğu tespit edilmiş olup organik içerikli gübrelerle eksiklik giderilebilir. Toprakların tüm fiziksel ve kimyasal özellikleri dikkate alındığında, Yeşilsırt köyü topraklarının elma, armut, erik ve kiraz yetiştiriciliğine uygun olduğu saptanmıştır

Cognitive Process of Development in Children

Science.gov (United States)

Boddington, Eulalee N.

2009-01-01

In this article we explored the theories of Arnold Gesell, Erik Erickson and Jean Piaget about how human beings development. In this component we will analyze the cognitive processes of how children perceive and develop, in particular children from a cross-cultural background. How learning takes place, and how the influences of culture, and…

Praomys degraaffi, a new species of Muridae (Mammalia) from ...

African Journals Online (AJOL)

Praomys degraaffi, a new species of Muridae (Mammalia) from central Africa. Erik van der ... It occurs at high elevations in montane forests of the Albertine Rift. The new ... following museums and private cotlections: American Mu- seum of Natural ...... edge of the park and in rather dry dense bush and sometimes up to I meter ...

Effect of fungicide on the development of wheat stem rust and yield ...

African Journals Online (AJOL)

Stem rust caused by Puccinia graminis f.sp tritici Erik. & E. Henn. is a highly destructive disease of wheat (Triticum aestivum L.). The effects of fungicide application on stem rust (Puccinia graminis tritici) epidemics and yield of three bread wheat varieties varying in reaction to the disease were studied in two major wheat ...

The Impact of Chronic Illness on Psychosocial Stages of Human Development.

Science.gov (United States)

Lapham, E. Virginia, Ed.; Shevlin, Kathleen M., Ed.

This book addresses critical issues regarding the impact of chronic illness and disability on human development. It was written for health care professionals who help chronically ill and disabled persons deal with the psychological and social as well as the biological aspects of their illness or disability. An expanded version of Erik Erikson's…

The Application of a Generativity Model for Older Adults

Science.gov (United States)

Ehlman, Katie; Ligon, Mary

2012-01-01

Generativity is a concept first introduced by Erik Erikson as a part of his psychosocial theory which outlines eight stages of development in the human life. Generativity versus stagnation is the main developmental concern of middle adulthood; however, generativity is also recognized as an important theme in the lives of older adults. Building on…

Anticorrosion potential of hydralazine for corrosion of mild steel in ...

African Journals Online (AJOL)

Anticorrosion potential of mild steel by Hydralazine as corrosion inhibitor for mild steel in 1M hydrochloric acid was investigated by chemical and electrochemical measurements at 303-333 K temperature. The maximum inhibition efficiency of inhibitor by Weight loss method is around 90%, Tafel polarization method is ...

Genetic analysis of rust resistance genes in global wheat cultivars: an overview

International Nuclear Information System (INIS)

Aktar-Uz-Zaman, Md; Tuhina-Khatun, Mst; Hanafi, Mohamed Musa; Sahebi, Mahbod

2017-01-01

Rust is the most devastating fungal disease in wheat. Three rust diseases, namely, leaf or brown rust caused by Puccinia triticina Eriks, stem or black rust caused by Puccinia graminis f. sp. tritici West, and stripe or yellow rust caused by Puccinia striiformis f. Tritici Eriks, are the most economically significant and common diseases among global wheat cultivars. Growing cultivars resistant to rust is the most sustainable, cost-effective and environmentally friendly approach for controlling rust diseases. To date, more than 187 rust resistance genes (80 leaf rust, 58 stem rust and 49 stripe rust) have been derived from diverse wheat or durum wheat cultivars and the related wild species using different molecular methods. This review provides a detailed discussion of the different aspects of rust resistance genes, their primitive sources, their distribution in global wheat cultivars and the importance of durable resistant varieties for controlling rust diseases. This information will serve as a foundation for plant breeders and geneticists to develop durable rust-resistant wheat varieties through marker-assisted breeding or gene pyramiding

Tillid

DEFF Research Database (Denmark)

Olsen, Jan Brødslev

2015-01-01

leves uden tillid. Kapitlet gennemgår to centrale teoretiske bud på tillid, nemlig den danske livsfilosofi repræsenteret af Knud Eiler Løgstrups teori om de spontane og suveræne livsytringer samt den psykodynamiske teoretiker Erik H. Erikson. I forbindelse med disse knyttes en række beslægtede teorier...... mennesket i møde, får vi hos psykoanalytikeren Erik H. Erikson en ontogenetisk forklaring på tilliden. Erikson ser tillid som resultatet af den succesfulde omsorg, et barn modtager i sit første leveår. Når vi senere møder et andet menneske i hverdagslivet, vil vi møde dette menneske med den tillid eller...... skitseres. Erikson-delen af kapitlet afsluttes med en samfundsmæssig perspektivering fra den engelske sociolog Anthony Giddens, der samtidig udgør et slags modsvar til Zygmunt Bauman. Kapitlet sammenfatter de præsenterede teorier om tillid som en både intra- og interpsykologisk kvalitet og tillige som både...

Morphology, chemical composition , and electrochemical characteristics of colored titanium passive layers

International Nuclear Information System (INIS)

Jerkiewicz, G.; Hrapovic, S.; Vatankhah, G.; Luan, B.L.

1999-01-01

Brightly and uniformly colored passive layers on Ti are formed by application of AC polarization in aqueous NH 4 BF 4 . A wide spectrum of well-defined colors is accomplished by varying the AC voltage. The passive films are stable in the ambient and in aqueous chloride, perchlorate, sulfate solutions. Optical microscopy and SEM analyses indicate that the passive layers are compact and do not reveal fractures or cracks. XPS characterization of the colored passive layers reveals that their surface-chemical composition depends on the AC polarization voltage. The main constituents of the passive layers are Ti z+ , O 2- , and F - (z varies from 4 to 2 depending on the depth). Fluoride in the film originates form decomposition of NH 4 BF 4 and it accumulates at the inner metal/passive-film interface. XPS depth profiling shows that the higher the AC voltage applied, the thicker the passive film formed. Electrochemical properties of the colored Ti passive layers are determined by recording polarization curves in the -0.8 - 3.2 V, RHE, range and Tafel plots in the hydrogen evolution reaction (HER) region in 1.0 M aqueous H 2 SO 4 solution. The polarization curves show that the corrosion potential of the colored passive layers shifts towards less-negative potential indicating that they are more stable than Ti under the same conditions. The Tafel plots for the HER demonstrate that the passive layers have much higher activity than Ti towards the HER. The Tafel relations reveal new features that can be associated with the partial breakdown/decomposition of the passive layers and with H absorption. (author)

Neitsitorni suudab äratada ainult valitsus / Mari Kodres

Index Scriptorium Estoniae

Kodres, Mari

2009-01-01

Taani soovib Tallinna linnamüüri Neitsitorni rentida Taani Kultuuri Instituudile ning oleks valmis Neitsitorni ja Taani Kuninga aia renoveerimiseks raha eraldama. Taani arhitekt Erik Nobel on koostanud eelprojekti, kuid Neitsitorn on seisnud tühjalt kolm aastat ning laguneb ja hallitab. Kinnistut taotleb endale USA-s elav Uno Werner. Neitsitorni lähiajaloost, seotusest loomeisikutega

Летняя кухня - функционально и красиво / Тийна Кольк

Index Scriptorium Estoniae

Кольк, Тийна

2010-01-01

Valik arhitektuurikonkursile "Väike 2007-2009" esitatud väikeobjektidest. Korvamäe suveköök (Urmas Muru, Peeter Pere, Reet Viigipuu, Karl Õiger), Mähe puhkemaja väliköök (Emil Urbel, Indrek Erm), aiamaja Pelgulinnas (Madis Eek), Suurupi aiapaviljon (Peep Roosmann), Tabasalu vaskeramu grillikoht (Urmas Muru, Peeter Pere, Anna-Maria Erik, Ago Kuddu)

Grillipaviljon, väliköök, varjualune... / Tiina Kolk

Index Scriptorium Estoniae

Kolk, Tiina

2010-01-01

Tutvustatakse valikut arhitektuurikonkursile "Väike 2007-2009" esitatud õueobjektidest. Suurupi aiapaviljon (Peep Roosmann), aiamaja Pelgulinnas (Madis Eek), Mähe puhkemaja väliköök (Emil Urbel, Indrek Erm), Korvamäe suveköök (Urmas Muru, Peeter Pere, Reet Viigipuu, Karl Õiger), Tabasalu vaskeramu grillikoht (Urmas Muru, Peeter Pere, Anna-Maria Erik, Ago Kuddu)

Praksisfortællingens læringsrum

DEFF Research Database (Denmark)

Olsen, Jan Brødslev

2005-01-01

, selvstændighed og kreativitet det centrale omdrejningspunkt. Essenstankegangen findes i såvel filosofisk som psykologisk litteratur med K. E. og Løgstrup og Erik Erikson som kendte repræsentanter. Denne form for læring kan kaldes ’essenslæring’, der udgør et helt konkret arbejdsredskab for den pædagogiske...

Baltic beer market : close neighbours, different situations

Index Scriptorium Estoniae

2004-01-01

Baltimaade juhtivate õlletootjate marketingijuhid Martins Dzenis (Cesu Alus), Inita Drezina (Aldaris), Eriks Kalita (Livu Alus), Raimonds Kalnins (Kimmel), Dalius Rutkauskas (AB Ragutis), Dainius Smailys (Svyturis-Utenos Alus), Katrin Vernik (A. Le Coq Eesti), Karin Sepp (Saku Õlletehas) ja Härmo Põlluvee (Frederik Viru Õlu) olukorrast Baltimaade õlleturul, suurematest tarbijamängudest ja reklaamikampaaniatest. Tabelid

Läti sakslane Brotze ja Eesti ajalugu / Anne Untera

Index Scriptorium Estoniae

Untera, Anne, 1951-

2006-01-01

Näitus "Johann Christoph Brotze joonistusi ja käsikirju Eesti- ja Liivimaast Läti Akadeemilise Raamatukogu kogudest" Kuressaare lossis kuni 30. IV. Eesti ainestikuga eriköide Brotze pärandist valmib Eesti-Läti uurijate koostöös ja ilmub Tallinnas. Väljaande peatoimetaja on Raimo Pullat, alajaotuste toimetajad Ants Hein, Ivar Leimus, Ants Viires

Round-table discussion at Tallinn City Council (March 8, 2010). Part one : The European Union strategy for the Baltic Sea Region - a challenge for cooperation on local and regional levels

Index Scriptorium Estoniae

2010-01-01

Konverentsi ümarlaual võtsid sõna Erik Terk, Toomas Vitsut, Thomas Johansson, Katrin Savomägi, Jasmin Etelämäki, Edvins Karnitis, Ulf Johansson, Per Gudmund Lindencrona, Mika Keränen, Uno Aldegren, Georg Sootla, Heikki Telakivi, Piret Hedin, Mart Repnau, Jüri Riives, Madis Kanarbik, Enn Saar, Tiiu Evert, Galina Gribanova, Keijo Sahrman, Linda Talve

Four Predictions for Students' Tomorrows

Science.gov (United States)

Palmer, Erik

2016-01-01

What pieces of their education do adults actually use? Many highly successful people gain success without remembering large amounts of material that schools teach. Erik Palmer suggests that educators to take a closer look at what parts of their education have been critical to your adult success and what they wish they had been taught. In addition,…

APLICAÇÕES CONTEMPORÂNEAS DA TEORIA DE INTELIGÊNCIAS MÚLTIPLAS: APRENDIZADO PARA O ENSINO DE ADMINISTRAÇÃO

Directory of Open Access Journals (Sweden)

Caio Giusti Bianchi

2015-03-01

Alemanha nazista. Em 1961 ele ingressou na Universidade de Harvard com o objetivo de graduar em História, porém Erik Erikson, Jerome Bruner e Jean Piaget influenciaram a sua trajetória na universidade para realizar pesquisas voltadas para a psicologia clínica e o desenvolvimento humano (WINNER, s.d..

Corrosion and passivation of copper in artificial sea water

International Nuclear Information System (INIS)

Chon, Jung Kyoon; Kim, Youn Kyoo

2007-01-01

Based on the cyclic voltammograms, potentiodynamic polarizations, transient and steady state Tafel plots and electrochemical impedance spectroscopy, we proposed the copper redox mechanism of the corrosion and passivation in artificial sea water. The copper redox mechanism showed the dependence of the concentration of oxygen in artificial sea water and electrode potentials

Türkiye ve Almanya’daki Coğrafya Öğretim Programlarının Karşılaştırılması / Comparisons of Geography Teaching Programs in Turkey and Germany

Directory of Open Access Journals (Sweden)

Mehmet Fatih KAYA

2011-06-01

Full Text Available Bu çalışmada; Türkiye’de 2005, Almanya’da ise 2004 yılından itibaren liselerde uygulanmaya başlanan Coğrafya Öğretim Programları karşılaştırılmıştır. Bu araştırma, lise Coğrafya Öğretim Programları’nın hedef, içerik, öğretme-öğrenme ve değerlendirme süreçlerini tespit etmeye yönelik bir araştırma şeklinde tasarlanmıştır. Araştırma nitel bir desene sahiptir. Araştırmanın evrenini Türkiye ve Almanya’da lise Coğrafya Öğretim Programları oluşturmaktadır. Örneklemini ise Türkiye’deki lise 9. sınıflar, Almanya’da ise nüfus miktarı ve yoğunluğu en fazla olan Nordhrhein-Westfalen eyaletindeki lise 9. sınıflar teşkil etmektedir. Coğrafya Öğretim Programları içerik analizine uygun olarak incelenmiş ve elde edilen bulgular doğrultusunda programlar; hedef, içerik, öğretme-öğrenme süreci ve değerlendirme süreci açısından karşılaştırılmıştır. Yaptığımız araştırmada şu sorulara cevap aranmıştır: Türkiye ve Almanya’daki Coğrafya Öğretim Programı’nın benzer ve farklılıkları nelerdir? Türkiye ve Almanya’daki Coğrafya Öğretim Programı’nın hedef, içerik, öğretme-öğrenme süreci ve değerlendirme süreci açısından olumlu ve olumsuz yönleri nelerdir? Her iki programın da benzerlik göstermekle birlikte birtakım farklılıkları da içerdiği tespit edilmiştir. Elde edilen bulgular ışığında araştırmacılara, öğretmenlere ve program geliştirme uzmanlarına bazı önerilerde bulunulmuştur.

The oxygen evolution reaction on cobalt Part I. Reaction order experiments and impedance measurements

NARCIS (Netherlands)

Kobussen, A.G.C.; Willems, H.; Wit, J.H.W. de; Broers, G.H.J.

1984-01-01

It was found that the oxygen evolution reaction on cobalt in concentrated KOH solutions can be described differently for low and high overpotentials. In the overpotential range from 150 to 280 mV, the reaction has a Tafel slope of approximately 40 mV and a reaction order with respect to the KOH

Corrosion inhibition behavior of Ketosulfone for Zinc in acidic medium

African Journals Online (AJOL)

The corrosion inhibition behavior of Ketosulfone for zinc is investigated by polarization and AC-impedance techniques at 303-333K. The Tafel plots indicates that the Ketosulfone is a mixed type inhibitor. The interaction between metal and inhibitor is explained by Langmuir adsorption isotherm. DG0ads andDH0ads value ...

Antibiotica, een vloek of een zegen?

NARCIS (Netherlands)

Muiswinkel, van W.B.

2011-01-01

In Aquacultuur 2010, nr. 5 stond op pagina 33 van het artikel "Aan tafel bij Sietze Leenstra" de opmerking, dat antibiotica het immuunsysteem verstoren. Hier is wel iets voor te zeggen, maar toch moeten we oppassen, dat we niet alle antibiotica op één hoop smijten. Volgens de auteur is het vooral

Plaadid / Liina Valdre, Erik Aru, Tiiu Laks...[jt.

Index Scriptorium Estoniae

2007-01-01

Uutest heliplaatidest Dylan Donkin "Food For Thoughtlessness", Kreatiivmootor "Irratsionaalne", Coco Electrik "Army Behind The Sun", Marc Collin featuring Katrine Ottosen & Valente "Two For The Road", Korn "Untitled"

Baltikumi õlletehased laenavad üksteise ideid / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2006-01-01

Baltimaades toimuvast õlletehaste liitumisest, Baltic Beverages Holding ja Soome õlletootja Olvi tütarettevõtetest Eestis. Lisad: Viie suurima seas tihe rebimine; Õlletootjad pürivad aina kõrgemale. Tabel: Õllemaailma suured

Erakordne aeg või valed mudelid? / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2008-01-01

Paul De Grauwe, Leonardo Iania ja Pablo Rovira Kaltwasser arvutasid välja börsidel erakordsemate päevade esinemise tõenäosuse. Nende järelduse kohaselt ei ole mitte praegune aeg erakordne, vaid finantsmudelid on valed. Lisa: Indeks Dow Jones Industrial Average oktoobrikuus

Hiltonid ostavad Scandicu omaniku ära / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2005-01-01

Briti Hilton Group peab läbirääkimisi USA hotelliketiga Hilton Hotels Corporation, et müüa oma hotelliäri. Hilton Groupile kuulub kaubamärk Scandic, Eestis tegutsevad selle kaubamärgi all kolm hotelli. Tabel: 2004. aasta majandustulemused. Lisa: Kahel Hiltonil ühised juured

Saal. Ovaal. Salong. Gong / Erik Linnumägi

Index Scriptorium Estoniae

Linnumägi, Erik, 1925-2004

1996-01-01

Tartu 'Vanemuise' ovaalsaalist ja seal toimuvatest salongiõhtutest. 'Mu kurbused on alasti' (I. Hirve luule); 'Lõpetamata romanss' (I. Bunin ja tema novell 'Zoika ja Valeria'); 'Elulootus' (D. Kareva, A. Alliksaare, J. Viidingu ning U. Masingu luule)

Skype tuleb arvutist välja / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2006-01-01

Müügile tulevad telefonid ja telefoniadapterid, millega saab Skype'i teel helistada. Skype sõlmis koostöölepingu Briti mobiiltelefonioperaatoriga 3, mis opereerib 3G-võrkudega. Skype Technologies OÜ tegevjuhi Sten Tamkivi kommentaare. EMT laiendab oma 3G-võrku, alanud on ehitus 3G-võrgu rajamiseks Tartusse. Lisad: Vonage pürib börsile; Pojuke, misse skaip on? Hurraa-optimismi aeg internetiäris möödumas?

Google annab kõigi pihta turmtuld / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2010-01-01

Google'ile kuuluva operatsioonisüsteemiga Android varustatud telefonide müük edestas II kvartalis Microsofti Windows Mobile'i rakendavate müüki üle kolme korra, II kvartalis jõudis Android müüginäitajate poolest ette ka Apple'ist. Google kavatseb käivitada YouTube'i baasil tasuliste videote teenuse

Henrik Gottlieb and Jens Erik Mogensen (Editors). Dictionary ...

African Journals Online (AJOL)

rbr

for the empirical analyses on which the papers are based, often deal with the ... and printed reference works cannot keep up with the pace of change. In addi- tion, new ... forms in a particular language and its implications for lexicographical activities such as corpus .... The accounting dictionary under discussion is conceptu-.

Bastion loobub oma kinnisvarast / Erik Müürsepp

Index Scriptorium Estoniae

Müürsepp, Erik

2008-01-01

Rõivatootja Bastion eraldab oma varadest kinnisvara ja kannab selle üle OÜ Bastion Kinnisvara omandisse. Omanik Indrek Stahli sõnul lähevad kinnisvara eraldamisega selgemaks tootmisettevõtte näitajad. Bastioni müük on kolme kvartaliga vähenenud vaid 5,8%

Valitsus ja 400 riigiametnikku kolivad Narva / Erik Gamzejev

Index Scriptorium Estoniae

Gamzejev, Erik, 1967-

2007-01-01

Narvas toimub kahepäevane riigiametnike foorum, kus arutatakse koos kutsutud teadlaste ja välisekspertidega riigijuhtimise päevakajalisi probleeme. Ilmunud ka: Severnoje Poberezhje, 2. okt. 2007, lk. 1

Kreenholm loobub Usbekistani puuvillast / Erik Müürsepp

Index Scriptorium Estoniae

Müürsepp, Erik

2007-01-01

Kreenholm peatas ajutiselt Usbekistanist puuvilla tarnimise, sest väidetavalt kasutatakse Usbekistanis puuvilla korjamisel lapstööjõudu. Usbekistani puuvilla osakaal ettevõtte tarnetes on vaid 8%, USA puuvilla osakaal on aga kuni 50%

Määdness in da haus! / Erik Morna

Index Scriptorium Estoniae

Morna, Erik, 1969-

2006-01-01

Autor tutvustab kahtkümmet ebatavalise kujuga elupaika USA-s, Jaapanis, Hiinas, Hollandis, Austrias, Saksamaal, Inglismaal, Tšehhis (arhitekt Frank Gehry), Itaalias (arhitekt Mario Cavalle) ja Eestis - pilpamaja Suure-Jaanis

Skype murdis arvutist välja / Erik Rand

Index Scriptorium Estoniae

Rand, Erik

2006-01-01

Vt. ka Postimees : na russkom jazõke 24. juuli, lk. 9. Seni vaid arvutist kõnesid teha võimaldanud Skype pakub nüüd kaasaskantavaid telefone, millega saab kõnelda igal pool, kus on avalik WiFi võrk

Yeni Ad, Yeni Sayı, Yeni Web Sayfası ve Zengin İçerik

Directory of Open Access Journals (Sweden)

Ömer Aslan

2016-06-01

şlarınca da kullanılan İntihali Engelleme Programında kontrol edilmektedir. Bu yayın döneminde rapor sonucu yüzde on beşten fazla benzerlik içeren çalışmalar, yazarlarına ilgili intihal raporuyla iade edildi.“Yazarın hakemleri, hakemlerin ise yazarı öğrenememesi (Çift Taraflı Kör Hakemlik ilkesi” 20/1. sayımızda da titizlikle uygulandı. Bu ilkenin daha etkin işletilebilmesi amacıyla 2016 yılından itibaren hakem isimlerinin yayımlanmamasına karar verildi. Bir Sonraki Sayımız (20.2015 Aralık 2016- Hakkında Hatırlatmalar15 Aralık  2016 tarihinde yayımlanacak 20 cilt 2. sayımız için 01 Haziran 2016-15 Ekim 2016 tarihleri arasında makale kabul edilecektir. 15 Ekim 2016 tarihinden sonra sisteme yüklenen makaleler ise 2017 yılının haziran ayında yayımlanacak sayımız için hakem değerlendirmesine tâbi tutulacaktır.Hakem değerlendirmesinden geçen makalelerin Türkçe ve İngilizce 150 kelimelik “Öz/Abstract” ile birlikte 750 kelimelik “Özet/Summary” içermesi de talep edilecektir.Taşıdığımız misyon ve sahip olduğumuz formatla her geçen gün ilim dünyasının ilgisini daha fazla gördüğümüzü ifade etmemiz gerekmektedir. Ocak-Haziran 2016 döneminde akademisyenlerimizden 63 çalışma değerlendirilmek üzere dergimize ulaşmıştır. Bu makaleler öncelikle Yazar Rehberimizde belirtilen şekilsel özellikler açısından ön değerlendirmeye tâbi tutuldu. Sonra da intihal tespit programı kullanılarak kontrol edildi. Bu aşamaları geçen makaleler hakem değerlendirmesine sunuldu. Bu sayımızda, söz konusu 63 çalışma içinden ön değerlendirme ve intihal taramasından geçen, hakemlerimizin de akademik içerik açısından yayımlanmasını uygun bulduğu 18 makale ile bir çeviri sizlerle buluştu. Altı doktora tez özeti, üç kitap değerlendirmesi ve bir sempozyum tanıtımı bu sayımızda yer aldı.Elinizdeki sayı ile yine birbirinden farklı konuları havi bilimsel nitelikteki makaleleri

Activation of factor VII bound to tissue factor: A key early step in the tissue factor pathway of blood coagulation

International Nuclear Information System (INIS)

Rao, L.V.M.; Rapaport, S.I.

1988-01-01

Whether the factor VII/tissue factor complex that forms in tissue factor-dependent blood coagulation must be activated to factor VIIa/tissue factor before it can activate its substrates, factor X and IX, has been a difficult question to answer because the substrates, once activated, back-activate factor VII. The earlier studies suggested that human factor VII/tissue factor cannot activate factor IX. Studies have now been extended to the activation of factor X. Reaction mixtures were made with purified factor VII, X, and tissue factor; in some experiments antithrombin III and heparin were added to prevent back-activation of factor VII. Factor X was activated at similar rates in reaction mixtures containing either VII or factor VIIa after an initial 30-sec lag with factor VII. In reaction mixtures with factor VII a linear activation of factor X was established several minutes before cleavage of 125 I-labeled factor VII to the two-chain activated molecule was demonstrable on gel profiles. These data suggest that factor VII/tissue factor cannot activate measurable amounts of factor X over several minutes. Overall, the results support the hypothesis that a rapid preferential activation of factor VII bound to tissue factor by trace amounts of factor Xa is a key early step in tissue factor-dependent blood coagulation

Simulation of X-ray signals

International Nuclear Information System (INIS)

Weller, A.

1980-12-01

A parameterized form of the local emissivity is used for the simulation of soft X-ray signals obtained on the WENDELSTEIN W VII-A stellarator with a 30 diode array. Numerical calculation of the line integrals for the different viewing angles and for a set of rotation angles covering one full signal period provides simulated periodic signals. In addition radial profiles of the line integrated emmission averaged over some time interval or at specific times, the relative amplitude modulation and the relative phase of the oscillations are calculated. These have to be fitted to the corresponding measured signals and profiles in order to get a reliable picture of the local emissivity. The model can take into account two poloidally asymmetric contributions of the type m = 1,2,3 or 4 (m = poloidal mode number). Each asymmetry can be generated in two ways (modulation of intensity and of geometry parameters). Besides an uniform rotation of the asymmetric terms some specific simple time evolution of the signals can be included (non-uniform rotation, growth of oscillations, sawtooth oscillations). The various input parameters are illustrated and the result of a simulation procedure is presented for a particular discharge in W VII-A. (orig.)

Using XML/HTTP to Store, Serve and Annotate Tactical Scenarios for X3D Operational Visualization and Anti-Terrorist Training

Science.gov (United States)

2003-03-01

PXSLServlet Paul A. Open Source Relational x X 23 Tchistopolskii sql2dtd David Mertz Public domain Relational x -- sql2xml Scott Hathaway Public...March 2003. [Hunter 2001] Hunter, David ; Cagle, Kurt; Dix, Chris; Kovack, Roger; Pinnock, Jonathan, Rafter, Jeff; Beginning XML (2nd Edition...Postgraduate School Monterey, California 4. Curt Blais Naval Postgraduate School Monterey, California 5 Erik Chaum NAVSEA Undersea

First HIV legal precedent in Kyrgyzstan: breach of medical privacy.

Science.gov (United States)

Iriskulbekov, Erik; Balybaeva, Asylgul

2007-12-01

A recent court case of a breach of the privacy rights of a person living with HIV/AIDS in Kyrgyzstan is the first of its kind in Central Asia, write Erik Iriskulbekov and Asylgul Balybaeva. ADILET, the NGO that brought the case to court, is one of only a few NGOs in Central Asia that provide legal assistance related to HIV and AIDS.

VI rahvusvaheline turismikonverents : Eesti turism muutuste keerises: võimalused, uuendused, eristumine

Index Scriptorium Estoniae

2011-01-01

Eesti Turismifirmade Liidu, EASiu Turismiarenduskeskuse ning Majandus- ja Kommunikatsiooniministeeriumi poolt 29. septembril Sokos Hotel Virus korraldatud VI rahvusvahelisest turismikonverentsist "Eesti turism muutuste keerises: võimalused, uuendused, eristumine", kus anti välja ka Turismiuuendaja ja EDEN auhinnad. Konverentsi moderaator oli Tallinna Lennujaama juhatuse liige Erik Sakkov. Lühiülevaade Maria Alajõe, Joakim Heleniuse, Rohit Talwari, Marje Josingu, Martin Schoberti ettekannetest

Iskusstvo objekta / Galina Balashova

Index Scriptorium Estoniae

Balashova, Galina

2006-01-01

Tallinna IV rakenduskunsti triennaalist "Kaks lähedast" Eesti Tarbekunsti- ja Disainimuuseumis. Triennaali erikülalise inglise ehtekunstniku Wendy Ramshaw ehtesarjast "Picasso's ladies". Maris Galise, Krista Leesi, Andrea Petrakovièi, Rozemarijn Van der Moleni, Kärt Summataveti, Hilde Foksi, Jurgita Erminaite, Piret Valgu, Jurate Petruskeviciene, Tine Deweerdt'i, Ave Maseri ja Kadri Pärnametsa töödest näitusel

The Life Cycle Completed. Extended Version with New Chapters on the Ninth Stage of Development by Joan M. Erikson.

Science.gov (United States)

Erikson, Erik H.

This expanded edition of a 1982 book by Erik Erikson summarizes his work on the stages of the human life cycle, including chapters on psychosexuality and the cycle of generations, major stages in psychosocial development, and ego and ethos. An additional chapter on the ninth stage sets forth his philosophy on old age--i.e. the 80s and 90s--and how…

Juugendstiil / Mai Levin

Index Scriptorium Estoniae

Levin, Mai, 1942-

2010-01-01

Suurte metropolide mõju. Heimatkunst. Kristjan Raua naivism. Ants Laikmaa pastellid. Paul Raud ja juugend. Eestlased Peterburis. Nikolai Triigi ekspressionismigeenidega stiilsus. Konrad Mägi lõõmavad värvid. Aleksander Tassa minimalism. Roman Nyman ja teatridekoratsioon. August Jansen ja Peet Aren ning vene maalikool. Herbert Lukk. Laikmaa õpilased. Varaküps Erik Obermann. Balder Tomasberg. Eduard Wiiralt. Jaan Koorti juugendlik algus. Tarbekunst

Redox switching and oxygen evolution at oxidized metal and metal oxide electrodes: iron in base.

Science.gov (United States)

Lyons, Michael E G; Doyle, Richard L; Brandon, Michael P

2011-12-28

Outstanding issues regarding the film formation, redox switching characteristics and the oxygen evolution reaction (OER) electrocatalytic behaviour of multicycled iron oxyhydroxide films in aqueous alkaline solution have been revisited. The oxide is grown using a repetitive potential multicycling technique, and the mechanism of the latter hydrous oxide formation process has been discussed. A duplex layer model of the oxide/solution interphase region is proposed. The acid/base behaviour of the hydrous oxide and the microdispersed nature of the latter material has been emphasised. The hydrous oxide is considered as a porous assembly of interlinked octahedrally coordinated anionic metal oxyhydroxide surfaquo complexes which form an open network structure. The latter contains considerable quantities of water molecules which facilitate hydroxide ion discharge at the metal site during active oxygen evolution, and also charge compensating cations. The dynamics of redox switching has been quantified via analysis of the cyclic voltammetry response as a function of potential sweep rate using the Laviron-Aoki electron hopping diffusion model by analogy with redox polymer modified electrodes. Steady state Tafel plot analysis has been used to elucidate the kinetics and mechanism of oxygen evolution. Tafel slope values of ca. 60 mV dec(-1) and ca. 120 mV dec(-1) are found at low and high overpotentials respectively, whereas the reaction order with respect to hydroxide ion activity changes from ca. 3/2 to ca. 1 as the potential is increased. These observations are rationalised in terms of a kinetic scheme involving Temkin adsorption and the rate determining formation of a physisorbed hydrogen peroxide intermediate on the oxide surface. The dual Tafel slope behaviour is ascribed to the potential dependence of the surface coverage of adsorbed intermediates.

Lanthanides-based graphene catalysts for high performance hydrogen evolution and oxygen reduction

International Nuclear Information System (INIS)

Shinde, S.S.; Sami, Abdul; Lee, Jung-Ho

2016-01-01

Highlights: • Facile, scalable in-situ synthesis of lanthanide (La, Eu, Yb) doped graphene frameworks. • Efficient electrocatalytic performance towards HER and ORR. • Eu-Gr hybrid shows HER performance; onset & overpotential (81 & 160 mV), & Tafel slope (52 mV dec −1 ). • Eu-Gr exhibits superior activity of ORR; onset potential (0.92 V), electron transfer number (4.03). • Excellent long-term stability in HER and ORR, comparable to those of commercial Pt/C catalysts. - Abstract: The design of efficient electrocatalysts for hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) has received enormous consideration due to their effectiveness in modern renewable energy technologies such as fuel cells, electrolyzers, and metal–air batteries. Herein, we present a facile method to fabricate lanthanides (L = La, Eu, Yb)-doped graphene materials as catalyst for the HER and ORR that show desirable electrocatalytic activities as well as long-term stability. The Eu-graphene hybrid has showed unbeatable HER performance such as small values of onset potential (81 mV), overpotential (160 mV), and Tafel slope (52 mV dec −1 ), along with a high exchange current density (7.55 × 10 −6 A cm −2 ). The L-graphenes also exhibit superior electrocatalytic activity for ORR, including small Tafel slopes (96, 66, and 105 mV dec −1 for La-Gr, Eu-Gr, and Yb-Gr, respectively), positive onset potential (∼0.83–0.92 V), high electron transfer numbers (∼3.84–4.03), and excellent enduring strength, analogous to those of viable Pt/C catalysts. The excellent electrocatalytic performance is attributed to the synergistic effect of abundant edges and doping sites, high electrical conductivity, large active surface areas and fast charge transfer; which renders lanthanide-based graphene hybrids as potentially great candidate for energy conversion systems.

Electrocatalytic properties of prussian blue nanoparticles supported on poly(m-aminobenzenesulphonic acid)-functionalised single-walled carbon nanotubes towards the detection of dopamine

CSIR Research Space (South Africa)

Adekunle, AS

2012-06-01

Full Text Available with increasing PB layers. The catalytic rate constant of 1.69 × 105 mol-1 cm3 s-1, Tafel value of 112 mV dec-1, and limit of detection of DA (2.8 nM) were obtained. Dopamine could be simultaneously detected with ascorbic acid. The electrode was found...

Efficient hydrogen production on MoNi4 electrocatalysts with fast water dissociation kinetics

Science.gov (United States)

Zhang, Jian; Wang, Tao; Liu, Pan; Liao, Zhongquan; Liu, Shaohua; Zhuang, Xiaodong; Chen, Mingwei; Zschech, Ehrenfried; Feng, Xinliang

2017-05-01

Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 electrocatalyst supported by MoO2 cuboids on nickel foam (MoNi4/MoO2@Ni), which is constructed by controlling the outward diffusion of nickel atoms on annealing precursor NiMoO4 cuboids on nickel foam. Experimental and theoretical results confirm that a rapid Tafel-step-decided hydrogen evolution proceeds on MoNi4 electrocatalyst. As a result, the MoNi4 electrocatalyst exhibits zero onset overpotential, an overpotential of 15 mV at 10 mA cm-2 and a low Tafel slope of 30 mV per decade in 1 M potassium hydroxide electrolyte, which are comparable to the results for platinum and superior to those for state-of-the-art platinum-free electrocatalysts. Benefiting from its scalable preparation and stability, the MoNi4 electrocatalyst is promising for practical water-alkali electrolysers.

Surface protection of mild steel in acidic chloride solution by 5-Nitro-8-Hydroxy Quinoline

Directory of Open Access Journals (Sweden)

R. Ganapathi Sundaram

2018-03-01

Full Text Available The effect of commercially available quinoline nucleus based pharmaceutically active compound 5-Nitro-8-Hydroxy Quinoline (NHQ against the corrosion of mild steel (MS in 1 M acidic chloride (HCl solution was investigated by chemical (weight loss – WL and electrochemical (Tafel polarization, Linear polarization and Electrochemical impedance spectroscopy techniques. From all the four methods, it is inferred that the percentage of inhibition efficiency increases with increasing the inhibitor concentration from 50 to 300 ppm. The adsorption behavior of inhibitor obeyed through Langmuir isotherm model. Thermodynamic parameters were also calculated and predict that the process of inhibition is a spontaneous reaction. EIS technique exhibits one capacitive loop indicating that, the corrosion reaction is controlled by charge transfer process. Tafel polarization studies revealed that the investigated inhibitor is mixed type and the mode of adsorption is physical in nature. The surface morphologies were examined by FT-IR, SEM and EDX techniques. Theoretical quantum chemical calculations were performed to confirm the ability of NHQ to adsorb onto mild steel surface. Keywords: Acidic chloride solution, MS, NHQ, WL, SEM, FT-IR

Synthesis and characterization of osmium carbonyl cluster compounds with molecular oxygen electroreduction capacity

Energy Technology Data Exchange (ETDEWEB)

Castellanos, R.H.; Ocampo, A.L.; Moreira-Acosta, J.; Sebastian, P.J. [CIE-UNAM Solar Energy Laboratory, Morelos (Mexico). Photovoltaic Systems Group, Solar-Hydrogen-Fuel Cell

2001-12-01

A transition metal cluster electrocatalyst based on Os{sub x}(CO){sub n} was synthesized by pyrolysis of Os{sub 3} (CO){sub 12} in 1,2-Dichlorobenzene (b.p.{approx_equal}180{sup o}C) under inert atmosphere (N{sub 2}). The electrocatalytic parameters of the oxygen reduction reaction (ORR) for an Os{sub x}(CO){sub n} catalyst were studied with a rotating disk electrode in 0.5 MH{sub 2}SO{sub 4} electrolyte. The diffusion coefficient and solubility of O{sub 2} in 0.5 MH{sub 2}SO{sub 4} were calculated. Koutecky-Levich analysis of the linear voltamperometry data showed that the reaction follows first-order kinetics and the value of the Koutecky-Levich slope indicates a multielectron charge transfer during the ORR. The value of the Tafel slope obtained from the mass transfer corrected Tafel plots is 131 mV/decade. The performance of the catalyst in a H{sub 2}/O{sub 2} PEM fuel cell cathode was evaluated and found to be nearly as good as that of Pt. (author)

Hamid Karzai on küll Afganistani riigipea, aga Massoud on kangelane / Leslie Leino

Index Scriptorium Estoniae

Leino, Leslie

2005-01-01

Afganistani valimistel võitsid opositsionäärid, tugevaim figuur nende hulgas on Ahmad Shah Massoudi kunagine kaasvõitleja Yunus Qanun, kelle siht on võõrväed riigist välja viia ja riik ühendada. Ameeriklased ja nende liitlased on ärevil, sest Qanun pole võõrvägede hulgas populaarne. Lisa: Põhimõtteliselt ameeriklaste vastu. Vt. samas: Afganistanis alustas pärast 30-aastast pausi tööd parlament

Patterns of regional cerebellar atrophy in genetic frontotemporal dementia

Directory of Open Access Journals (Sweden)

Martina Bocchetta

2016-01-01

Conclusion: There appears to be a differential pattern of cerebellar atrophy in the major genetic forms of FTD, being relatively spared in GRN, localized to the lobule VIIa-Crus I in the superior-posterior region of the cerebellum in C9orf72, the area connected via the thalamus to the prefrontal cortex and involved in cognitive function, and localized to the vermis in MAPT, the ‘limbic cerebellum’ involved in emotional processing.

Kuni 10 kaitseväelast Malisse

Index Scriptorium Estoniae

2013-01-01

Valitsus saatis riigikokku eelnõu, mille kohaselt võib Eesti saata Euroopa Liidu väljaõppemissioonile Malis kuni 10 kaitseväelast. Kaitsevägi panustaks staabiohvitseridega, kelle peamiseks ülesandeks on osaleda Mali üksustele erinevate riikide poolt läbiviidava väljaõppe planeerimise ja nõustamise protsessides ning väljaõppemeeskonnaga, kelle ülesandeks on viia läbi Mali üksustele mitmesugust sõjalist väljaõpet

Electrochemical maps and movies of the hydrogen evolution reaction on natural crystals of molybdenite (MoS2): basal vs. edge plane activity† †Electronic supplementary information (ESI) available: Movies S1 to S4: spatially resolved LSV-SECCM movies obtained from the electrocatalytic HER on the surface of bulk MoS2. Fig. S1 to S14: XRD, XPS, Raman, SEM and OM characterization of MoS2; SEM images of the nanopipets; WCA measurements; LSVs and Tafel plots obtained from the HER on MoS2. See DOI: 10.1039/c7sc02545a Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Science.gov (United States)

Kang, Minkyung; Maddar, Faduma M.; Li, Fengwang; Walker, Marc; Zhang, Jie

2017-01-01

Two dimensional (2D) semiconductor materials, such as molybdenum disulfide (MoS2) have attracted considerable interest in a range of chemical and electrochemical applications, for example, as an abundant and low-cost alternative electrocatalyst to platinum for the hydrogen evolution reaction (HER). While it has been proposed that the edge plane of MoS2 possesses high catalytic activity for the HER relative to the “catalytically inert” basal plane, this conclusion has been drawn mainly from macroscale electrochemical (voltammetric) measurements, which reflect the “average” electrocatalytic behavior of complex electrode ensembles. In this work, we report the first spatially-resolved measurements of HER activity on natural crystals of molybdenite, achieved using voltammetric scanning electrochemical cell microscopy (SECCM), whereby pixel-resolved linear-sweep voltammogram (LSV) measurements have allowed the HER to be visualized at multiple different potentials to construct electrochemical flux movies with nanoscale resolution. Key features of the SECCM technique are that characteristic surface sites can be targeted and analyzed in detail and, further, that the electrocatalyst area is known with good precision (in contrast to many macroscale measurements on supported catalysts). Through correlation of the local voltammetric response with information from scanning electron microscopy (SEM) and atomic force microscopy (AFM) in a multi-microscopy approach, it is demonstrated unequivocally that while the basal plane of bulk MoS2 (2H crystal phase) possesses significant activity, the HER is greatly facilitated at the edge plane (e.g., surface defects such as steps, edges or crevices). Semi-quantitative treatment of the voltammetric data reveals that the HER at the basal plane of MoS2 has a Tafel slope and exchange current density (J 0) of ∼120 mV per decade and 2.5 × 10–6 A cm–2 (comparable to polycrystalline Co, Ni, Cu and Au), respectively, while the edge

Yeni Ad, Yeni Sayı, Yeni Web Sayfası ve Zengin İçerik

Directory of Open Access Journals (Sweden)

Ömer Aslan

2016-06-01

gerekmektedir. Ocak-Haziran 2016 döneminde akademisyenlerimizden 63 çalışma değerlendirilmek üzere dergimize ulaşmıştır. Bu makaleler öncelikle Yazar Rehberimizde belirtilen şekilsel özellikler açısından ön değerlendirmeye tâbi tutuldu. Sonra da intihal tespit programı kullanılarak kontrol edildi. Bu aşamaları geçen makaleler hakem değerlendirmesine sunuldu. Bu sayımızda, söz konusu 63 çalışma içinden ön değerlendirme ve intihal taramasından geçen, hakemlerimizin de akademik içerik açısından yayımlanmasını uygun bulduğu 18 makale ile bir çeviri sizlerle buluştu. Altı doktora tez özeti, üç kitap değerlendirmesi ve bir sempozyum tanıtımı bu sayımızda yer aldı.Elinizdeki sayı ile yine birbirinden farklı konuları havi bilimsel nitelikteki makaleleri sizlerle buluşturmanın mutluluğunu yaşamaktayız. Bu süreçte başta makale sahibi değerli bilim adamlarımıza, yayın, danışma ve hakem kurullarımıza, Rektörlüğümüz Basımevi personeline ve özellikle dergimizin yayın aşamasında yadsınmaz emekleri olan editör yardımcılarımız Arş. Gör. Maruf Çakır, Yrd. Doç. Dr. Adem Çiftçi ve Yrd. Doç. Dr. Sema Yılmaz ile İngilizce dil kontrolü sorumluluğunu üstlenen editör yardımcılarımız Arş. Gör. Zeynep Ceran ile Dr. Emrah Kaya ve Zeynep Yücedoğru’ya teşekkür ederiz. 15 Aralık 2016 tarihinde yayımlanacak bir sonraki sayımızda buluşmak ümidiyle…15 June 2016SivasÖmer ASLAN & Abdullah DEMİREditör 

EXTRACT OF COMBRETUM MICRANTHUM AS CORROSION ...

African Journals Online (AJOL)

user

2016-10-04

Oct 4, 2016 ... methanol extract CM is a good adsorption inhibitor for the corrosion of Al-Si-Mg in 3.5wt% NaCl solution. Tafel polarization analysis indicates that the studied plant extract is a mixed ..... (2008). [2] Shreir, L. L., Jarman, R. A. and Burstein, G. T.. Corrosion ... [6] Maqsood Ahmad Malik, Mohammad Ali Hashim,.

Electrochemical, surface analytical and quantum chemical studies ...

Indian Academy of Sciences (India)

subject of numerous studies due to their high technological value and wide range .... Mulliken population analysis of atoms in triazole derivatives, depending on the ... 2102–0003) with an accelerating voltage of 20 kV, at a scan speed=slow 5 and ... the corrosion rate can also be determined by Tafel extra- polation of either ...

Kuhu riiki oma firma masust taastuma viia? / Villi Tõntson

Index Scriptorium Estoniae

Tõntson, Villi, 1975-

2010-01-01

PricewaterhouseCoopersi ja Maailmapanga koostöös valminud maksukeskkondade võrdlevast uuringust "Paying Taxes 2010", kus üks hüpoteetiline ettevõte paigutati eri riikidesse ning seejärel reastati riigid vastavalt ettevõtte maksukoormusele, riiklike ja kohalike maksude hulgale ning maksude maksmiseks kulunud ajale. Graafik

Biophysical characterisation of GlycoPEGylated recombinant human factor VIIa

DEFF Research Database (Denmark)

Plesner, Bitten; Westh, Peter; Nielsen, Anders D.

2011-01-01

The effects of GlycoPEGylation on the structural, kinetic and thermal stability of recombinant human FVIIa were investigated using rFVIIa and linear 10 kDa and branched 40 kDa GlycoPEGylated® recombinant human FVIIa derivatives. The secondary and tertiary structure of rFVIIa measured by circular...... dichroism (CD) was maintained upon PEGylation. In contrast, the thermal and kinetic stability of rFVIIa was affected by GlycoPEGylation, as the apparent unfolding temperature Tm measured by differential scanning calorimetry (DSC) and the temperature of aggregation, Tagg, measured by light scattering (LS......) both increased with GlycoPEGylation. Both Tm and Tagg were independent of the molecular weight and the shape of the PEG chain. From the present biophysical characterisation it is concluded that after GlycoPEGylation, rFVIIa appears to be unaffected structurally (secondary and tertiary structure...

Zirconium oxide deposits (ZrO{sub 2}) and titanium oxide (TiO{sub 2}) on 304l stainless steel; Depositos de oxido de circonio (ZrO{sub 2}) y oxido de titanio (TiO{sub 2}) sobre acero inoxidable 304L

Energy Technology Data Exchange (ETDEWEB)

Davila N, M. L.

2015-07-01

This research project aims to carry out the surface and electrochemical characterization to obtain the optimum conditions of the hydrothermal deposits of zirconium oxide ZrO{sub 2} (baddeleyite) and titanium oxide TiO{sub 2} (anatase and rutile phases) on 304l stainless steel, simulating an inhibiting protective layer. 304l steel specimens were cut, pre-oxidized in water at a temperature of 288 degrees Celsius and 8 MPa, similar to those of a typical BWR conditions. From the titanium oxide anatase crystalline phase, the rutile phase was obtained by a heat treatment at 1000 degrees Celsius. The Sigma-Aldrich pre-oxidized powders and steel 304l were characterized using techniques of X-ray diffraction, scanning electron microscopy, X-ray dispersive energy, chemical mapping and Raman spectrometry. The pre-oxidized steel has two oxide layers, an inner layer with nano metric crystals and another outer of larger crystals to 1μm, with the formation of hematite and magnetite, this predominating. The surface that contacted the sample holder has larger crystals. Hydrothermal deposits were carry out from suspensions of 10, 100 and 1000 ppm, of the crystal phases of anatase, rutile and baddeleyite, on the pre-oxidized steel at a temperature of 150 degrees Celsius for 2 and 7 days, samples were analyzed by X-ray diffraction, scanning electron microscopy, X-ray dispersive energy, Raman spectrometry and Tafel polarization. The suspension to 1000 ppm for 7 days coated surface most; the baddeleyite deposit is noticed more homogeneous than anatase and rutile. The deposit is favored when hematite and magnetite crystals are larger. The chemical mapping on deposits show that even after being immersed in water to 288 degrees Celsius during 30 days, the deposits are still present although a loss is observed. A reference electrode was assembled to conduct electrochemical tests of Tafel able to withstand a temperature of 288 degrees Celsius and pressure of 8 MPa. The baddeleyite deposit

Zirconium oxide deposits (ZrO2) and titanium oxide (TiO2) on 304l stainless steel

International Nuclear Information System (INIS)

Davila N, M. L.

2015-01-01

This research project aims to carry out the surface and electrochemical characterization to obtain the optimum conditions of the hydrothermal deposits of zirconium oxide ZrO 2 (baddeleyite) and titanium oxide TiO 2 (anatase and rutile phases) on 304l stainless steel, simulating an inhibiting protective layer. 304l steel specimens were cut, pre-oxidized in water at a temperature of 288 degrees Celsius and 8 MPa, similar to those of a typical BWR conditions. From the titanium oxide anatase crystalline phase, the rutile phase was obtained by a heat treatment at 1000 degrees Celsius. The Sigma-Aldrich pre-oxidized powders and steel 304l were characterized using techniques of X-ray diffraction, scanning electron microscopy, X-ray dispersive energy, chemical mapping and Raman spectrometry. The pre-oxidized steel has two oxide layers, an inner layer with nano metric crystals and another outer of larger crystals to 1μm, with the formation of hematite and magnetite, this predominating. The surface that contacted the sample holder has larger crystals. Hydrothermal deposits were carry out from suspensions of 10, 100 and 1000 ppm, of the crystal phases of anatase, rutile and baddeleyite, on the pre-oxidized steel at a temperature of 150 degrees Celsius for 2 and 7 days, samples were analyzed by X-ray diffraction, scanning electron microscopy, X-ray dispersive energy, Raman spectrometry and Tafel polarization. The suspension to 1000 ppm for 7 days coated surface most; the baddeleyite deposit is noticed more homogeneous than anatase and rutile. The deposit is favored when hematite and magnetite crystals are larger. The chemical mapping on deposits show that even after being immersed in water to 288 degrees Celsius during 30 days, the deposits are still present although a loss is observed. A reference electrode was assembled to conduct electrochemical tests of Tafel able to withstand a temperature of 288 degrees Celsius and pressure of 8 MPa. The baddeleyite deposit presented

Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors

Directory of Open Access Journals (Sweden)

Neamati Nouri

2009-04-01

Full Text Available Abstract Correction to Erik Serrao, Srinivas Odde, Kavya Ramkumar and Nouri Neamati: Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors. Retrovirology 2009, 6:25. Since the recent publication of our article (Neamati, Retrovirology 2009, 6:25, we have noticed an error which we would like to correct and we would like to apologise to the readers for this mistake.

This is not a bomb / Triin Männik

Index Scriptorium Estoniae

Männik, Triin

2005-01-01

Moskva I rahvusvaheline kaasaja kunsti biennaali lisaprogrammist. Erikülalistena esinesid Christian Boltanski, Bill Viola, Michal Rovner, Ilja Kabakov. Informbüroo projektist, Andrei Jerofejevi kureeritud "Kaasosaliste" ülevaatenäitusest Tretjakovi galeriis, näitusest "Invasioon" ja Robert Mapplethorpe'i fotode väljapanekust Moskva fotograafiakeskuses, näitustest "Post-diasporaa : rännakud ja missioonid" (kuraator Olga Kopenkina) ja "Sooprobleemid" Moskva moodsa kunsti muuseumis

Tallinna sadamaala linnaruumiline arengukava : ettepanek = Urban Development Plan for the Tallinn Port Area : Proposal

Index Scriptorium Estoniae

2006-01-01

Tellija: Tallinna Linnaplaneerimise Amet. Korraldaja: Eesti Arhitektide Liit. Aeg: 2006. a. veebruar. Osalejad: linnageograaf Hardo Aasmäe, arhitektid Andres Alver, Rein Hansberg, Veljo Kaasik, Ott Kadarik, Erik Konze, Margit Mutso, Tiit Sild, Villem Tomiste, TLPA juht, Tallinna peaarhitekt Igor Volkov, Tallinna Sadama esindaja Hannes Kuhlbach, TLPA projektijuht Jaan Kurm, TLPA üldplaneeringute osakonna juhataja Endrik Mänd, Logi Projekti esindaja Taimi Lokotar, Heldur Meerits