Unges udeliv - i multietniske boligområder

DEFF Research Database (Denmark)

Børresen, Sølvi Karin; Schytte, Benny

Rapporten omhandler de unges udeliv i multietniske boligområder, hvor opmærksomheden er rettet mod hverdagslivet og de unges adfærd og anvendelse af udemiljøet i boligområderne. Endvidere gives der eksempler på konkrete tiltag og problemløsninger i relation til de unges anvendelse af udemiljøet. ....... Undersøgelsen er fortaget i de tre boligområder: AKB Lundtoftegade på Ydre Nørrebro i København, Vollsmose i Odense og Gellerup ved Århus....

Unges motivation og læring

DEFF Research Database (Denmark)

Sørensen, Niels Ulrik; Katznelson, Noemi; Hutters, Camilla

Uddannelse er en helt central del af det moderne ungdomsliv, men en del unge har svært ved at tage sig sammen, og resultatet er ofte problemer med fravær, frafald og skoletræthed. I denne bog belyses unges motivation for læring og uddannelse set i lyset af de forandringer, der præger samfundet...

Unge bliver ofre for kortsigtet rekruttering

DEFF Research Database (Denmark)

Nielsen, Rikke Kristine

2013-01-01

Rip-Rap-Rup-effekt: Det er fristende at hyre en kandidat med 10-20-30 års ballast fra arbejdsmarkedet. Men er det langsigtet at se bort fra de unge og mindre erfarne?......Rip-Rap-Rup-effekt: Det er fristende at hyre en kandidat med 10-20-30 års ballast fra arbejdsmarkedet. Men er det langsigtet at se bort fra de unge og mindre erfarne?...

Small size neutron tube UNG-1

International Nuclear Information System (INIS)

Bespalov, D.F.; Mints, A.Z.; Shkol'nikov, A.S.

A tube UNG-1 (universal neutron gas-filled) is designed for the use in the well neutron generators IGN-1 and IGN-1-M (a pulse neutron generator). Their serial production in the USSR has been started in 1963. At the same year, the serial production of the tubes UNG-1 has been started. Thus, this tube is the first serial logging accelerating tube in the USSR. A Penning source, equipped with a hot cathode, was selected as an ion source of the tube

Passion og (dis)engagement blandt unge i udskolingen

DEFF Research Database (Denmark)

Rasmussen, Maj Sofie

Afhandlingen er baseret på et kvalitativt studie af 11 unge fra 9. klasse i Fryshuset i Stockholm... Det overordnede formål er at undersøge marginaliserende og overskridende bevægelser i relation til læring, tilblivelse og engagement for de unge i Fryshusets grundskole der har elevernes passioner...

Unge og online sociale netværk

DEFF Research Database (Denmark)

Larsen, Malene Charlotte

I denne ph.d.-afhandling udforskes 12-18-årige danske børn og unges brug af et af den seneste tids nyere internetfænomener: Online sociale netværk. De såkaldte sociale netværkssider (SNS’er) er internetbaserede mødesteder, hvor brugere via personaliserede profiler kan liste hinanden som venner og...... for danske unges brug af online sociale netværk....

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik; Ozmec, Martha Nina

I rapporten Når det er svært at være ung i DK – unges trivsel og mistrivsel i tal offentliggør Center for Ungdomsforskning resultaterne af en stor videnskabelig spørgeskemaundersøgelse om trivsel og mistrivsel blandt 15-24-årige unge i Danmark. Rapporten indgår i det treårige forskningsprojekt Når...... det er svært at være ung i DK, som Center for Ungdomsforskning udfører med støtte fra Egmont Fonden. Rapporten bygger på telefoninterviews med 3.481 unge, der udgør et repræsentativt udsnit af alle 15-24-årige unge i Danmark. I rapporten forfølges de unges trivsel og mistrivsel gennem to spor: 1) Et...

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik

Når det er svært at være ung i DK – viden og råd om unges trivsel og mistrivsel er afslutningen på et større forskningsprojekt om unges trivsel og mistrivsel. Hæftet præsenterer forskningsprojektets hovedkonklusioner og giver desuden en række råd og ideer til, hvordan voksne kan hjælpe unge med...... at håndtere mistrivsel. Hæftet er udarbejdet af forskerne Jens Christian Nielsen og Niels Ulrik Sørensen fra Center for Ungdomsforskning. Det er den sidste publikation i forskningsprojektet Når det er svært at være ung i DK, der fra 2008-2011 har belyst unges trivsel og mistrivsel. Projektet bygger både på en...

Unge, Holdspil og Medborgerskab

DEFF Research Database (Denmark)

Ryom, Knud Eske

coaching/mentoring. Behovet for dette skal ses i lyset af en senmoderne kontekst, hvor udvikling blandt unge i vid udstrækning handler om at ”skabe sig selv” og synes karakteriseret ved en udpræget grad af kollektivt orienteret individualisme. Dermed forekommer det plausibelt, at der er en sammenhæng......, coaching/mentoring og læring. Derefter præsenteres de enkelte metodiske værktøjer (multimethod), som har været brugt til at indsamle empiri. Hvordan det kan kobles en kvantitative metode som spørgeskemaer i et aktionsforskningsprojekt diskuteres også, samt hvordan metoderne er brugt strategisk undervejs i...... medborgerskab introduceres. Hvorefter mere generelle emner bearbejdes, såsom: a) Unge fra socialt udsatte boligområder, med fokus på hvordan samfundet oplever denne gruppe. b) Nogle af de særlige kendetegn ved det senmoderne samfund, og hvordan coaching og identitet bliver relevant i et sådant samfund. c...

The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover.

Directory of Open Access Journals (Sweden)

Xiaoyun Wen

Full Text Available The HIV1 protein Vpr assembles with and acts through an ubiquitin ligase complex that includes DDB1 and cullin 4 (CRL4 to cause G2 cell cycle arrest and to promote degradation of both uracil DNA glycosylase 2 (UNG2 and single-strand selective mono-functional uracil DNA glycosylase 1 (SMUG1. DCAF1, an adaptor protein, is required for Vpr-mediated G2 arrest through the ubiquitin ligase complex. In work described here, we used UNG2 as a model substrate to study how Vpr acts through the ubiquitin ligase complex. We examined whether DCAF1 is essential for Vpr-mediated degradation of UNG2 and SMUG1. We further investigated whether Vpr is required for recruiting substrates to the ubiquitin ligase or acts to enhance its function and whether this parallels Vpr-mediated G2 arrest.We found that DCAF1 plays an important role in Vpr-independent UNG2 and SMUG1 depletion. UNG2 assembled with the ubiquitin ligase complex in the absence of Vpr, but Vpr enhanced this interaction. Further, Vpr-mediated enhancement of UNG2 degradation correlated with low Vpr expression levels. Vpr concentrations exceeding a threshold blocked UNG2 depletion and enhanced its accumulation in the cell nucleus. A similar dose-dependent trend was seen for Vpr-mediated cell cycle arrest.This work identifies UNG2 and SMUG1 as novel targets for CRL4(DCAF1-mediated degradation. It further shows that Vpr enhances rather than enables the interaction between UNG2 and the ubiquitin ligase. Vpr augments CRL4(DCAF1-mediated UNG2 degradation at low concentrations but antagonizes it at high concentrations, allowing nuclear accumulation of UNG2. Further, the protein that is targeted to cause G2 arrest behaves much like UNG2. Our findings provide the basis for determining whether the CRL4(DCAF1 complex is alone responsible for cell cycle-dependent UNG2 turnover and will also aid in establishing conditions necessary for the identification of additional targets of Vpr-enhanced degradation.

Kommunepakken - Forebyggelse af selvmordsforebyggelse hos børn og unge

DEFF Research Database (Denmark)

Juul Larsen, Kim

2006-01-01

Kommunepakken - en vejledning til personale i socialsektoren Statistikken viser, at flere unge piger og drenge mellem 15 og 19 år forsøger at tage deres eget liv. For sagsbehandleren eller andet personale i den sociale sektor, som sidder over for et selvmordstruet barn eller ung, kan det skabe us...

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik; Grubb, Ane

I rapporten Når det er svært at være ung i DK – unges beretninger om mistrivsel og ungdomsliv præsenteres resultaterne af et kvalitativt studie af mistrivsel og ungdomsliv blandt 15-24-årige unge i Danmark. Studiet bygger på dybdegående interviews med 33 unge fra forskellige dele af landet, der...... fortæller om deres erfaringer med diverse mistrivselsformer, som ensomhed, selvskadende adfærd og mobning, og om deres besvær med at håndtere de krav, udfordringer og muligheder, der i øvrigt præger det moderne ungdomsliv. Studiet indgår i det treårige forskningsprojekt Når det er svært at være ung i DK...

Unges liv og muligheder

DEFF Research Database (Denmark)

Berliner, Peter; Fanous, Sandrine; Wattar, Laila

2010-01-01

trivsel og deltagelse kan øges. De unge deltog i fokusgruppeinterviews, individuelle interviews, udfyldelse af et spørgeskema, arrangering af et borgermøde samt i overvejelser omkring undersøgelsens metode og design og analysen af data. Analysen af data pegede på en række vigtige betingelser for at øge de...

Sammenbrud i anbringelser af unge: Erfaringer, forklaringer og årsagerne bag

DEFF Research Database (Denmark)

Egelund, Tine; Jakobsen, Turf Böcker; Cecilie Norn Hammen, Ida

”Det er altså langt fra et liv, det her,” fortæller 20-årige Anja om en af sine anbringelser, der endte i et sammenbrud. Anja blev første gang anbragt som 9-årig og har siden været anbragt 11 forskellige steder. Anjas historie viser, hvordan anbringelser af unge langt fra altid er succesfulde. Næ...... for hjemmet. Den bygger på en spørgeskemaundersøgelse blandt 227 unge, der blev anbragt i alderen 13-17 år, og på interview med nogle af disse unge, deres forældre, sagsbehandlere, pædagoger, kontaktpersoner m.fl....

Cloning and characterization of WRKY gene homologs in Chieh-qua (Benincasa hispida Cogn. var. Chieh-qua How) and their expression in response to fusaric acid treatment.

Science.gov (United States)

Mao, Yizhou; Jiang, Biao; Peng, Qingwu; Liu, Wenrui; Lin, Yue; Xie, Dasen; He, Xiaoming; Li, Shaoshan

2017-05-01

The WRKY transcription factors play an important role in plant resistance for biotic and abiotic stresses. In the present study, we cloned 10 WRKY gene homologs (CqWRKY) in Chieh-qua (Benincasa hispida Cogn. var. Chieh-qua) using the rapid-amplification of cDNA ends (RACE) or homology-based cloning methods. We characterized the structure of these CqWRKY genes. Phylogenetic analysis of these sequences with cucumber homologs suggested possible structural conservation of these genes among cucurbit crops. We examined the expression levels of these genes in response to fusaric acid (FA) treatment between resistant and susceptible Chieh-qua lines with quantitative real-time PCR. All genes could be upregulated upon FA treatment, but four CqWRKY genes exhibited differential expression between resistant and susceptible lines before and after FA application. CqWRKY31 seemed to be a positive regulator while CqWRKY1, CqWRKY23 and CqWRKY53 were negative regulators of fusaric resistance. This is the first report of characterization of WRKY family genes in Chieh-qua. The results may also be useful in breeding Chieh-qua for Fusarium wilt resistance.

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA

DEFF Research Database (Denmark)

Hagen, Lars; Kavli, Bodil; Sousa, Mirta M L

2008-01-01

-catalytic domain that confer distinct functional properties to UNG2. These are apparently generated by cyclin-dependent kinases through stepwise phosphorylation of S23, T60 and S64 in the cell cycle. Phosphorylation of S23 in late G1/early S confers increased association with replication protein A (RPA......) and replicating chromatin and markedly increases the catalytic turnover of UNG2. Conversely, progressive phosphorylation of T60 and S64 throughout S phase mediates reduced binding to RPA and flag UNG2 for breakdown in G2 by forming a cyclin E/c-myc-like phosphodegron. The enhanced catalytic turnover of UNG2 p-S23...

GeoViQua: quality-aware geospatial data discovery and evaluation

Science.gov (United States)

Bigagli, L.; Papeschi, F.; Mazzetti, P.; Nativi, S.

2012-04-01

GeoViQua (QUAlity aware VIsualization for the Global Earth Observation System of Systems) is a recently started FP7 project aiming at complementing the Global Earth Observation System of Systems (GEOSS) with rigorous data quality specifications and quality-aware capabilities, in order to improve reliability in scientific studies and policy decision-making. GeoViQua main scientific and technical objective is to enhance the GEOSS Common Infrastructure (GCI) providing the user community with innovative quality-aware search and evaluation tools, which will be integrated in the GEO-Portal, as well as made available to other end-user interfaces. To this end, GeoViQua will promote the extension of the current standard metadata for geographic information with accurate and expressive quality indicators, also contributing to the definition of a quality label (GEOLabel). GeoViQua proposed solutions will be assessed in several pilot case studies covering the whole Earth Observation chain, from remote sensing acquisition to data processing, to applications in the main GEOSS Societal Benefit Areas. This work presents the preliminary results of GeoViQua Work Package 4 "Enhanced geo-search tools" (WP4), started in January 2012. Its major anticipated technical innovations are search and evaluation tools that communicate and exploit data quality information from the GCI. In particular, GeoViQua will investigate a graphical search interface featuring a coherent and meaningful aggregation of statistics and metadata summaries (e.g. in the form of tables, charts), thus enabling end users to leverage quality constraints for data discovery and evaluation. Preparatory work on WP4 requirements indicated that users need the "best" data for their purpose, implying a high degree of subjectivity in judgment. This suggests that the GeoViQua system should exploit a combination of provider-generated metadata (objective indicators such as summary statistics), system-generated metadata (contextual

Unge med flere kulturer

DEFF Research Database (Denmark)

Singla, Rashmi

2010-01-01

, uddannelsessteder, arbejdsplads mv.). Det kan få en til at føle sig alene og ’udenfor’. Husk, at det ikke kun er dig som ung, men også forældre og din familie, der kan føle sig tilsidesat. For også de kan være udsat for forskelsbehandling relateret til etnicitet, køn og/eller alder (racisme, sexisme og ageisme) i...

Unge i kunst- og kulturprojekter

DEFF Research Database (Denmark)

Nielsen, Louise Yung; Sørensen, Niels Ulrik

for ungeaktiviteter i hele landet. Model forsøget, som nu har kørt i tre år, består af 10 projekter, der favner musik, teater, film, litteratur, arkitektur, projektmageri og design. Projekterne foldes ud i ungdomskulturhuse, kulturinstitutioner, folkeskoler og i offentlige rum, hvor unge færdes og lever. I...

Børn, unge og sociale netværkssider. Hvad ved vi?

DEFF Research Database (Denmark)

Larsen, Malene Charlotte

2012-01-01

været. Herefter skal vi se på, hvordan børn og unge selv begrunder deres brug af sociale netværkssider, og hvilke motiver der ligger bag deres mange timer foran skærmen. Dernæst sætter kapitlet fokus på børn og unges venskaber på sociale netværkssider, hvad der karakteriserer et venskab i dag, og...

Sårbare børn og unge i tandplejeregi i Danmark

DEFF Research Database (Denmark)

Uldum, Birgitte; Christensen, Hanne Nødgaard; Haubek, Dorte

2016-01-01

Hvorledes identificeres sårbare børn og unge i tandplejeregi i Danmark? I denne artikel sættes fokus på danske sårbare børn og unge i tandplejeregi og på udviklingen I Danmark siden 2009. En dansk spørgeskemaundersøgelse om tandplejens erfaring fra 2008 omtales kort. Der lægges vægt på det odonto...

Designing and implementing a Quality Broker: the GeoViQua experience

Science.gov (United States)

Papeschi, Fabrizio; Bigagli, Lorenzo; Masò, Joan; Nativi, Stefano

2014-05-01

GeoViQua (QUAlity aware VIsualisation for the Global Earth Observation System of Systems) is an FP7 project aiming at complementing the Global Earth Observation System of Systems (GEOSS) with rigorous data quality specifications and quality-aware capabilities, in order to improve reliability in scientific studies and policy decision-making. GeoViQua main scientific and technical objective is to enhance the GEOSS Common Infrastructure (GCI) providing the user community with innovative quality-aware search and visualization tools, which will be integrated in the GEOPortal, as well as made available to other end-user interfaces. To this end, GeoViQua will promote the extension of the current standard metadata for geographic information with accurate and expressive quality indicators. Employing and extending several ISO standards such as 19115, 19157 and 19139, a common set of data quality indicators has been selected to be used within the project. The resulting work, in the form of a data model, is expressed in XML Schema Language and encoded in XML. Quality information can be stated both by data producers and by data users, actually resulting in two conceptually distinct data models, the Producer Quality model and the User Quality model (or User Feedback model). GeoViQua architecture is built on the brokering approach successfully experimented within the EuroGEOSS project and realized by the GEO DAB (Discovery and Access Broker) which is part of the GCI. The GEO DAB allows for harmonization and distribution in a transparent way for both users and data providers. This way, GeoViQua can effectively complement and extend the GEO DAB obtaining a Quality augmentation Broker (DAB-Q) which plays a central role in ensuring the consistency of the Producer and User quality models. The GeoViQua architecture also includes a Feedback Catalog, a particular service brokered by the DAB-Q which is dedicated to the storage and discovery of user feedbacks. A very important issue

Detrimental effects of hypoxia-specific expression of uracil DNA glycosylase (Ung) in Mycobacterium smegmatis.

Science.gov (United States)

Kurthkoti, Krishna; Varshney, Umesh

2010-12-01

Mycobacterium tuberculosis is known to reside latently in a significant fraction of the human population. Although the bacterium possesses an aerobic mode of metabolism, it adapts to persistence under hypoxic conditions such as those encountered in granulomas. While in mammalian systems hypoxia is a recognized DNA-damaging stress, aspects of DNA repair in mycobacteria under such conditions have not been studied. We subjected Mycobacterium smegmatis, a model organism, to the Wayne's protocol of hypoxia. Analysis of the mRNA of a key DNA repair enzyme, uracil DNA glycosylase (Ung), by real-time reverse transcriptase PCR (RT-PCR) revealed its downregulation during hypoxia. However, within an hour of recovery of the culture under normal oxygen levels, the Ung mRNA was restored. Analysis of Ung by immunoblotting and enzyme assays supported the RNA analysis results. To understand its physiological significance, we misexpressed Ung in M. smegmatis by using a hypoxia-responsive promoter of narK2 from M. tuberculosis. Although the misexpression of Ung during hypoxia decreased C-to-T mutations, it compromised bacterial survival upon recovery at normal oxygen levels. RT-PCR analysis of other base excision repair gene transcripts (UdgB and Fpg) suggested that these DNA repair functions also share with Ung the phenomenon of downregulation during hypoxia and recovery with return to normal oxygen conditions. We discuss the potential utility of this phenomenon in developing attenuated strains of mycobacteria.

The Quantitative Reasoning for College Science (QuaRCS) Assessment in non-Astro 101 Courses II

Science.gov (United States)

Kirkman, Thomas W.; Jensen, Ellen

2017-06-01

The Quantitative Reasoning for College Science (QuaRCS) Assessment[1] aims to measure the pre-algebra mathematical skills that are often part of "general education" science courses like Astro 101. In four majors STEM classes, we report comparisons between QuaRCS metrics, ACT math, GPAO, and the course grade. In three of four classes QuaRCS QR score and ACT math were statistically significantly correlated (with r˜.6), however in the fourth course —a senior-level microbiology course— there was no statistically significantly correlation (in fact, rPhysics courses showed fractional sigma gains in QR, self-estimated math fluency and math importance, but not all of those increases were statistically significant. Using a QuaRCS map relating the questions to skill areas, we found graph reading, percentages, and proportional reasoning to be the most misunderstood skills in all four courses.[1] QuaRCS, Follette, et al.,2015, DOI: http://dx.doi.org/10.5038/1936-4660.8.2.2

Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

Directory of Open Access Journals (Sweden)

Hong Zan

2012-11-01

Full Text Available By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID-mediated deoxycytosine deamination, yielding deoxyuridine (dU, and dU glycosylation by uracil DNA glycosylase (Ung in antibody switch (S region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1−/− Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation, and CSR. Together with an S region spectrum of mutations similar to that of Rev1+/+ Ung−/− B cells, this suggests that Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1−/− Msh2−/− B cells. Rescue of CSR in Rev1−/− B cells by a catalytically inactive Rev1 mutant shows that the important role of Rev1 in CSR is mediated by Rev1’s scaffolding function, not its enzymatic function.

Hvornår er man ung?

DEFF Research Database (Denmark)

Gundelach, Peter; Nørregård-Nielsen, Esther C.

2002-01-01

Hvornår er man ung, og hvornår er man voksen? Er der forskelle i befolkningens værdier i forhold til arbejde og politik, når det undersøges ud fra henholdsvis et alders- eller generationsperspektiv? Baseret på data fra den danske del af den internationale værdiundersøgelse vises at der er så store...

Direct shoot regeneration via organogenesis in chieh- qua ...

African Journals Online (AJOL)

ajl6

2013-11-27

qua is an Asiatic crop widely farmed throughout southern China and Southeast Asia with a cultivation history of more than 300 years. ... genotype, explant type, seedling age, culture medium, concentration and a combination of ...

Unge mangler ikke viden om privatøkonomi

DEFF Research Database (Denmark)

Munch, Jannie; Larsen, Jill Bach; Vollstedt, Peter

2017-01-01

En undersøgelse blandt unge mellem 15 og 30 år lavet af forskere på UCN viser, at det ikke er mangel på privatøkonomisk viden, som afgør deres adfærd inden for privatøkonomiske beslutninger....

Unge og Sorg i trykte medier

OpenAIRE

Andersen, Helle Maria; Jønsson, Naja; Sund, Christina Brøns; Vastring, Helle; Wetterstein, Emilie Wolff

2008-01-01

In this project we investigate the ways in which the organisation, Unge og Sorg, can be pro-moted in print media. We take a starting point in an empirical study of the target audience by focussing on these audiences’ life situations, need of information, and perceptions of rele-vance, expense and value of information. The methodological basis of this project consists of social constructivism, qualitative focus groups, and creative methods. The theoretical foundation comprises a communication ...

Synergistic effects of UdgB and Ung in mutation prevention and protection against commonly encountered DNA damaging agents in Mycobacterium smegmatis.

Science.gov (United States)

Malshetty, Vidyasagar S; Jain, Ruchi; Srinath, Thiruneelakantan; Kurthkoti, Krishna; Varshney, Umesh

2010-03-01

The incorporation of dUMP during replication or the deamination of cytosine in DNA results in the occurrence of uracils in genomes. To maintain genomic integrity, uracil DNA glycosylases (UDGs) excise uracil from DNA and initiate the base-excision repair pathway. Here, we cloned, purified and biochemically characterized a family 5 UDG, UdgB, from Mycobacterium smegmatis to allow us to use it as a model organism to investigate the physiological significance of the novel enzyme. Studies with knockout strains showed that compared with the wild-type parent, the mutation rate of the udgB( -) strain was approximately twofold higher, whereas the mutation rate of a strain deficient in the family 1 UDG (ung(- )) was found to be approximately 8.4-fold higher. Interestingly, the mutation rate of the double-knockout (ung(-)/ udgB(-)) strain was remarkably high, at approximately 19.6-fold. While CG to TA mutations predominated in the ung(-) and ung(-)/udgB(-) strains, AT to GC mutations were enhanced in the udgB(-) strain. The ung(-)/udgB(-) strain was notably more sensitive to acidified nitrite and hydrogen peroxide stresses compared with the single knockouts (ung(-) or udgB(-)). These observations reveal a synergistic effect of UdgB and Ung in DNA repair, and could have implications for the generation of attenuated strains of Mycobacterium tuberculosis.

Hvad så? Unge hørehæmmede trivsel og livskvalitet i et sociologisk perspektiv

DEFF Research Database (Denmark)

Hansen, Niels-Henrik Møller

Unge hørehæmmedes situation har længe været ubelyst. Dette råder denne afhandling bod på. Med udgangspunkt i et omfattende empirisk materiale - heriblandt en stor kvantitativ undersøgelse - beskrives unge hørehæmmedes livssituation i en række forskellige sociale arenaer, såsom folkeskolen, arbejd...

SDT og børns og unges udvikling

DEFF Research Database (Denmark)

Ravn, Ib

2017-01-01

Hvilken rolle spiller autonomi i børns og unges udvikling? En temmelig stor rolle, ligesom et underskud af autonomi - som når forældre kontrollerer deres børn - er en væsentlig årsag til psykiske sygdomme. Det er resultatet af en stor forskningsoversigt offentliggjort af tre ledende kræfter bag s...... selvbestemmelsesteorien (Self-Determination Theory, SDT)....

Tværprofessionelt samarbejde om udsathed hos børn og unge

DEFF Research Database (Denmark)

Villumsen, Anne Marie Anker; Jakobsen, Ida Skytte; Lund, Jens Hansen

2015-01-01

begreb og fænomen, som ikke lader sig indfange i en absolut og statisk definition. Potentialet for både praksis og uddannelser ligger derfor i en erkendelse heraf. Samtidig synes der at være potentiale i, at man i hver enkelt samarbejdskonstellation og kontekst operationaliserer og præciserer......, at tværprofessionelt samarbejde er meget udbredt indenfor socialt arbejde med udsathed hos børn og unge, og det er tydeligt, at der er mange måder, hvorpå man kan samarbejde tværprofessionelt. Samtidig er både tværprofessionelt samarbejde såvel som udsathed hos børn og unge begge vanskelige og upræcise begreber og...

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition

International Nuclear Information System (INIS)

Broderick, Peter; Bagratuni, Tina; Vijayakrishnan, Jairam; Lubbe, Steven; Chandler, Ian; Houlston, Richard S

2006-01-01

The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variation in other BER pathway genes such as NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 also contribute to CRC susceptibility. To evaluate whether sequence variants of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes might act as CRC susceptibility alleles, we screened the coding sequence and intron-exon boundaries of these genes in 94 familial CRC cases in which involvement of known genes had been excluded. Three novel missense variants were identified NEIL2 C367A, TDG3 A196G and UNG2 C262T in patients, which were not observed in 188 healthy control DNAs. We detected novel germline alterations in NEIL2, TDG and UNG patients with CRC. The results suggest a limited role for NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 in development of CRC

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition

Energy Technology Data Exchange (ETDEWEB)

Broderick, Peter; Bagratuni, Tina; Vijayakrishnan, Jairam; Lubbe, Steven; Chandler, Ian; Houlston, Richard S [Section of Cancer Genetics, Brookes Lawley Building, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG (United Kingdom)

2006-10-09

The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variation in other BER pathway genes such as NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 also contribute to CRC susceptibility. To evaluate whether sequence variants of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes might act as CRC susceptibility alleles, we screened the coding sequence and intron-exon boundaries of these genes in 94 familial CRC cases in which involvement of known genes had been excluded. Three novel missense variants were identified NEIL2 C367A, TDG3 A196G and UNG2 C262T in patients, which were not observed in 188 healthy control DNAs. We detected novel germline alterations in NEIL2, TDG and UNG patients with CRC. The results suggest a limited role for NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 in development of CRC.

Kortlægning af evalueringer og undersøgelser af vejledning knyttet til vejledning af unge i UU-regi

DEFF Research Database (Denmark)

Skovhus, Randi Boelskifte; thomsen, rie

2013-01-01

Kortlægning af evalueringer og undersøgelser af vejledning knyttet til vejledning af unge i UU-regi 2004-2013. Et arbejdspapir......Kortlægning af evalueringer og undersøgelser af vejledning knyttet til vejledning af unge i UU-regi 2004-2013. Et arbejdspapir...

The Jovian and galactic electrons in the heliosphere as seen by the KET experiment on board the spacecraft named ULYSSE

International Nuclear Information System (INIS)

Rastoin, Cecile

1995-01-01

The KET electron telescope onboard the Ulysse spacecraft flawlessly provides measurements of electrons, protons and alphas of energies above some MeV. This present work focuses on the electron data analysis and interpretation from the Ulysse's launch in 90 to the beginning of 95. The first stage of the odyssey was the Jovian encounter in February 92. The MeV electrons are here used as markers of the magnetic field global structure. We specially study the complex and highly dynamic outer magnetosphere. With reference of previous fly-by, the KET observations permit to characterize the 10-hour modulation of the Jovian electron flux and spectrum and suggest a mechanism involving the rotation of the north low-latitude polar cap. The boundary layers are seen as thick regions with transitions from magnetosheath to magnetospheric particle populations and field properties. The electron anisotropy and flux discontinuities are investigated with support of field data and provide the first evidence of magnetic reconnection occurring around the Jovian magnetopause. Taking advantage of the gravity assistance of the giant planet, Ulysse dipped towards the south heliospheric regions. Along its trajectory KET has detected Jovian electrons in interplanetary space. The first type of events is non-diffusive, with rapid increases discovered by KET at less than 1 AU from the magnetosphere: Jovian electrons have probably escaped through reconnection process which preserves their spectrum modulation and anisotropy characteristics. The events of second category are diffusive, observed since launch up to 30 degrees south. This work highlights the roles of interplanetary shocks and of the heliospheric current sheet in the propagation. A 3D transport model including adiabatic deceleration is presented here and accounts for the Jovian electron flux detected along the Ulysse's trajectory. New estimates of the 3D diffusion coefficients are performed for MeV electrons: K(perpendicular) = 8 * 10

Udsatte børn og unge i den inkluderende skole

DEFF Research Database (Denmark)

Hedegaard-Sørensen, Lotte; Grumløse, Sine Penthin

2017-01-01

Denne artikel belyser, hvordan undervisningen i folkeskolen – mod de bedste politiske og pædagogiske (forskning og læ-reruddannelse) hensigter om inkludering – ekskluderer en gruppe udsatte børn og unge. Artiklen bygger på et forsk-ningsprojekt om inklusion og differentiering, som har haft fokus ...

Knickzone Extraction Tool (KET – A new ArcGIS toolset for automatic extraction of knickzones from a DEM based on multi-scale stream gradients

Directory of Open Access Journals (Sweden)

Zahra Tuba

2017-04-01

Full Text Available Extraction of knickpoints or knickzones from a Digital Elevation Model (DEM has gained immense significance owing to the increasing implications of knickzones on landform development. However, existing methods for knickzone extraction tend to be subjective or require time-intensive data processing. This paper describes the proposed Knickzone Extraction Tool (KET, a new raster-based Python script deployed in the form of an ArcGIS toolset that automates the process of knickzone extraction and is both fast and more user-friendly. The KET is based on multi-scale analysis of slope gradients along a river course, where any locally steep segment (knickzone can be extracted as an anomalously high local gradient. We also conducted a comparative analysis of the KET and other contemporary knickzone identification techniques. The relationship between knickzone distribution and its morphometric characteristics are also examined through a case study of a mountainous watershed in Japan.

Telefonitis: unge danskeres brug af telefonen i IT-tidsalderen

Directory of Open Access Journals (Sweden)

Gitte B. Stald

2000-09-01

Full Text Available Den udbredte brug af mobiltelefoner har sat fornyet fokus på telefonens betydning i vores tid. Som følge af den informationsteknologiske udvikling ændrer telefonen karakter fra at være en kanal for kommunikation til at være et medie for flere funktioner, samtidig med at dens konkrete og sym- bolske betydning forstærkes. Dette kan i særlig grad aflæses i større børns og unges brug af telefonen, der dels er karakteriseret ved stor selvfølgelig- hed, dels ved at have en betydning, der rækker ud over funktioner: den er markør af ungdomskultur, den er garant for tryghed, og den muliggør fast- holdelse af sociale og personlige relationer. Telefonen befordrer etablering- en af et virtuelt rum, hvor intimitet og fortrolighed er mulig. Set i lyset af den informationsteknologiske udvikling, der har bragt e-mail, chat og andre for- mer for on- og offline kommunikation ind i de fleste unge danskeres tilvæ- relse, er det interessant, at telefonen har fastholdt og endog forstærket sin betydning.

LABOUR USE IN SMALL-SCALE YAM PRODUCTION IN QUA'AN ...

African Journals Online (AJOL)

... articulate organization of rural labour markets and migrant labour to ensure availability throughout the production season. Key Words: Labour use, Double log (Cobb-Douglas) fuctional form, Marginal analysis, Qua'an Pan Local Government Area, Plateau State. Global Journal of Agricultural Sciences Vol.2(2) 2003: 118- ...

PsiQuaSP-A library for efficient computation of symmetric open quantum systems.

Science.gov (United States)

Gegg, Michael; Richter, Marten

2017-11-24

In a recent publication we showed that permutation symmetry reduces the numerical complexity of Lindblad quantum master equations for identical multi-level systems from exponential to polynomial scaling. This is important for open system dynamics including realistic system bath interactions and dephasing in, for instance, the Dicke model, multi-Λ system setups etc. Here we present an object-oriented C++ library that allows to setup and solve arbitrary quantum optical Lindblad master equations, especially those that are permutationally symmetric in the multi-level systems. PsiQuaSP (Permutation symmetry for identical Quantum Systems Package) uses the PETSc package for sparse linear algebra methods and differential equations as basis. The aim of PsiQuaSP is to provide flexible, storage efficient and scalable code while being as user friendly as possible. It is easily applied to many quantum optical or quantum information systems with more than one multi-level system. We first review the basics of the permutation symmetry for multi-level systems in quantum master equations. The application of PsiQuaSP to quantum dynamical problems is illustrated with several typical, simple examples of open quantum optical systems.

Unge er en flok egoistiske individualister, der har nok i sig selv

DEFF Research Database (Denmark)

Kofod, Anne

2005-01-01

 Nutidens unge har som oftest en tvetydig identitet: På én og samme tid søger de sammen i sociale fællesskaber og gør alt for at skille sig ud som individualister.   Udgivelsesdato: 27. september...

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression

DEFF Research Database (Denmark)

Aas, Per Arne; Pena Diaz, Javier; Liabakk, Nina Beate

2009-01-01

within the region of DNA marked by PA. Footprinting analysis and electrophoretic mobility shift assays of PA and putative AP-2 binding regions with HeLa cell nuclear extract and recombinant AP-2alpha protein indicate that AP-2 transcription factors are central in the regulated expression of UNG2 m......The PA promoter in the human uracil-DNA glycosylase gene (UNG) directs expression of the nuclear form (UNG2) of UNG proteins. Using a combination of promoter deletion and mutation analyses, and transient transfection of HeLa cells, we show that repressor and derepressor activities are contained......alpha, lacking the activation domain but retaining the DNA binding and dimerization domains, stimulated PA to a level approaching that of full-length AP-2, suggesting that AP-2 overexpression stimulates PA activity by a mechanism involving derepression rather than activation, possibly by neutralizing...

QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition

Directory of Open Access Journals (Sweden)

Chi-Hua Tung

2016-01-01

Full Text Available Background. Quaternary structures of proteins are closely relevant to gene regulation, signal transduction, and many other biological functions of proteins. In the current study, a new method based on protein-conserved motif composition in block format for feature extraction is proposed, which is termed block composition. Results. The protein quaternary assembly states prediction system which combines blocks with functional domain composition, called QuaBingo, is constructed by three layers of classifiers that can categorize quaternary structural attributes of monomer, homooligomer, and heterooligomer. The building of the first layer classifier uses support vector machines (SVM based on blocks and functional domains of proteins, and the second layer SVM was utilized to process the outputs of the first layer. Finally, the result is determined by the Random Forest of the third layer. We compared the effectiveness of the combination of block composition, functional domain composition, and pseudoamino acid composition of the model. In the 11 kinds of functional protein families, QuaBingo is 23% of Matthews Correlation Coefficient (MCC higher than the existing prediction system. The results also revealed the biological characterization of the top five block compositions. Conclusions. QuaBingo provides better predictive ability for predicting the quaternary structural attributes of proteins.

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

DEFF Research Database (Denmark)

Akbari, Mansour; Otterlei, Marit; Pena Diaz, Javier

2004-01-01

Nuclear uracil-DNA glycosylase UNG2 has an established role in repair of U/A pairs resulting from misincorporation of dUMP during replication. In antigen-stimulated B-lymphocytes UNG2 removes uracil from U/G mispairs as part of somatic hypermutation and class switch recombination processes. Using......, PCNA and DNA ligase, the latter detected as activity. Short-patch repair was the predominant mechanism both in extracts and UNG2-ARC from proliferating and less BER-proficient growth-arrested cells. Repair of U/G mispairs and U/A pairs was completely inhibited by neutralizing UNG...

Quo vadis Inhaltserschließung der Deutschen Nationalbibliothek? Herausforderungen und Perspektiven

Directory of Open Access Journals (Sweden)

Ulrike Junger

2015-03-01

Full Text Available Seit der Ausweitung des Pflichtexemplarrechts auf sog. unkörperliche Medienwerke im Jahr 2006 steht die Deutsche Nationalbibliothek (DNB vor der Herausforderung, über neue Wege zur Erzeugung bibliografischer Metadaten nachzudenken. Die steigende Menge an Publikationen, die es zu bearbeiten gilt, aber auch deren zunehmende Diversität, machen dies erforderlich. Für die Inhaltserschließung der DNB bedeutet das, dass andere Verfahren neben die intellektuelle Erschließung treten müssen. Die Entwicklung und Einführung automatischer Verfahren für Klassifikation und Beschlagwortung gehören ebenso dazu wie die Nutzung von Fremddaten oder die Gewinnung inhaltserschließender Daten über Konkordanzen. Dies hat Auswirkungen auf Arbeitsabläufe, Erschließungsinstrumente und -standards sowie Datenformate. Die DNB strebt ein Konzept für die Inhaltserschließung an, das zum Ziel hat, so viele Publikationen als möglich angemessen zu erschließen, um thematische Recherchen erfolgreich zu unterstützen. Since the extension of the legal deposit mandate to so-called non-physical publications in 2006, the Deutsche Nationalbibliothek (DNB has to deal with the challenge of finding new ways to create bibliographic metadata. This is due to the growing amount of publications and their increasing diversity. Consequently, in the area of subject cataloguing in DNB, intellectual cataloguing must be complemented by additional methods. These include the development and implementation of automated procedures for classification and indexing as well as the use of third party data or the production of subject data via mappings. All this has effects on the workflows, tools and standards for subject cataloguing and data formats. DNB aims at a concept for subject cataloguing which will make it possible to catalogue as many publications as possible in an appropriate way in order to successfully support topical searches

Ensuring consistency and persistence to the Quality Information Model - The role of the GeoViQua Broker

Science.gov (United States)

Bigagli, Lorenzo; Papeschi, Fabrizio; Nativi, Stefano; Bastin, Lucy; Masó, Joan

2013-04-01

GeoViQua (QUAlity aware VIsualisation for the Global Earth Observation System of Systems) is an FP7 project aiming at complementing the Global Earth Observation System of Systems (GEOSS) with rigorous data quality specifications and quality-aware capabilities, in order to improve reliability in scientific studies and policy decision-making. GeoViQua main scientific and technical objective is to enhance the GEOSS Common Infrastructure (GCI) providing the user community with innovative quality-aware search and visualization tools, which will be integrated in the GEOPortal, as well as made available to other end-user interfaces. To this end, GeoViQua will promote the extension of the current standard metadata for geographic information with accurate and expressive quality indicators. The project will also contribute to the definition of a quality label, the GEOLabel, reflecting scientific relevance, quality, acceptance and societal needs. The concept of Quality Information is very broad. When talking about the quality of a product, this is not limited to geophysical quality but also includes concepts like mission quality (e.g. data coverage with respect to planning). In general, it provides an indication of the overall fitness for use of a specific type of product. Employing and extending several ISO standards such as 19115, 19157 and 19139, a common set of data quality indicators has been selected to be used within the project. The resulting work, in the form of a data model, is expressed in XML Schema Language and encoded in XML. Quality information can be stated both by data producers and by data users, actually resulting in two conceptually distinct data models, the Producer Quality model and the User Quality model (or User Feedback model). A very important issue concerns the association between the quality reports and the affected products that are target of the report. This association is usually achieved by means of a Product Identifier (PID), but actually just

En kvalitativ undersøgelse – Narrativ gruppecoachings indvirkning på unge sportstalenter

DEFF Research Database (Denmark)

Behrens, Thomas Seiger; Gilkrog, Lene

2010-01-01

Narrativ gruppecoaching af unge sportstalenter - En kvalitativ undersøgelse af deltagerens oplevede effekter med interventionen Undersøgelsen tager udgangspunkt i et Team Danmark støttet forskningsprojekt af professor Reinhard Stelter. Dette projekt har til formål at undersøge den narrative...... gruppecoaching indvirkning på unge sportstalenters idræts- og hverdagsliv. En kvalitativ undersøgelsesdel blev gennemført af specialestuderende Lene Gilkrog og Thomas Behrens og bygger på dybdeinterviews med seks udvalgte deltagere i projektet. Denne undersøgelse viser mange gevinster ved at benytte narrativ...... meningsdannelse. Projektets resultater viser tydeligt, at der ligger et stort potentiale i den anvende narrativ gruppecoaching som mental tilgang til elitesporten – ikke mindst fordi udøverne udvikler deres syn på deres identitet som "hele" mennesker og ikke blot som sportsudøvere. Metoden kan helt sikkert...

Residue behavior and risk assessment of mixed formulation of imidacloprid and chlorfenapyr in chieh-qua under field conditions.

Science.gov (United States)

Huang, Jian Xiang; Liu, Cong Yun; Lu, Da Hai; Chen, Jia Jia; Deng, Yi Cai; Wang, Fu Hua

2015-10-01

A simple and rapid method based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed for the simultaneous determination of imidacloprid and chlorfenapyr residues in chieh-qua. Field trials were designed to investigate the dissipation and terminal residue behavior of the mixed formulation of imidacloprid and chlorfenapyr in chieh-qua in Guangzhou and Nanning areas. Risk assessment was performed by calculating the risk quotient (RQ) values. The developed analytical method exhibited recoveries of 89.9-110.3% with relative standard deviations (RSDs) of 2.8-12.5% at the spiked levels of 0.01, 0.10, and 1.00 mg/kg. The limit of detection (LOD) was 0.003 mg/kg, and the limit of quantification (LOQ) was 0.01 mg/kg for both imidacloprid and chlorfenapyr. It was found that the half-lives of imidacloprid in chieh-qua under field conditions were 3.3 and 3.5 days in Guangzhou and Nanning at a dose of 180 g ai/ha, while the half-lives of chlorfenapyr were 3.3 and 2.6 days, respectively. The terminal residues of imidacloprid and chlorfenapyr were from 0.01 to 0.21 mg/kg and from 0.01 to 0.46 mg/kg, respectively. Results of dietary exposure assessment showed that the RQ values were much lower than 1, indicating that the risk of imidacloprid and chlorfenapyr applied in chieh-qua was negligible to human health under recommended dosage and good agricultural practices. The proposed study would provide guidance for safe and reasonable use of imidacloprid and chlorfenapyr in chieh-qua cultivation in China.

Putting leaders on the couch. A conversation with Manfred F. R. Kets de Vries. Interview by Diane L. Coutu.

Science.gov (United States)

Kets de Vries, Manfred F

2004-01-01

Much of the business literature on leadership starts with the assumption that leaders are rational beings. But irrationality is integral to human nature, and inner conflict often contributes to the drive to succeed. Although a number of business scholars have explored the psychology of executives, Manfred F.R Kets de Vries has made the analysis of CEOs his life's work. In this article, Kets de Vries, a psychoanalyst, author, and instead professor, draws on three decades of study to describe the psychological profile of successful CEOs. He explores senior executives' vulnerabilities, which are often intensified by followers' attempts to manipulate their leaders. Leaders, he says, have an uncanny ability to awaken transferential processes--in which people transfer the dynamics of past relationships onto present interactions--among their employees and even in themselves. These processes can present themselves in a number of ways, sometimes negatively. What's more, many top executives, being middle-aged, suffer from depression. Mid-life prompts a reappraisal of career identity, and by the time a leader is a CEO, an existential crisis is often imminent. This can happen with anyone, but the probability is higher with CEOs, and senior executives because so many have devoted themselves exclusively to work. Not all CEOs are psychologically unhealthy, of course. Healthy leaders are talented in self-observation and self-analysis, Kets de Vries says. The best are highly motivated to spend time on self-reflection. Their lives are in balance, they can play, they are creative and inventive, and they have the capacity to be nonconformist. "Those who accept the madness in themselves may be the healthiest leaders of all," he concludes.

Emotional Intelligence: The Sine Qua Non for a Clinical Leadership Toolbox

Science.gov (United States)

Rao, Paul R.

2006-01-01

Over the past decade, it has become increasingly clear that although IQ and technical skills are important, emotional intelligence is the Sine Qua Non of leadership. According to Goleman [Goleman, D. (1998). What makes a leader? "Harvard Business Review," 93-102] "effective leaders are alike in one crucial way: they all have a high degree of…

Telefonitis: unge danskeres brug af telefonen i IT-tidsalderen

OpenAIRE

Gitte B. Stald

2000-01-01

Den udbredte brug af mobiltelefoner har sat fornyet fokus på telefonens betydning i vores tid. Som følge af den informationsteknologiske udvikling ændrer telefonen karakter fra at være en kanal for kommunikation til at være et medie for flere funktioner, samtidig med at dens konkrete og sym- bolske betydning forstærkes. Dette kan i særlig grad aflæses i større børns og unges brug af telefonen, der dels er karakteriseret ved stor selvfølgelig- hed, dels ved at have en bet...

Tractable flux-driven temperature, density, and rotation profile evolution with the quasilinear gyrokinetic transport model QuaLiKiz

Science.gov (United States)

Citrin, J.; Bourdelle, C.; Casson, F. J.; Angioni, C.; Bonanomi, N.; Camenen, Y.; Garbet, X.; Garzotti, L.; Görler, T.; Gürcan, O.; Koechl, F.; Imbeaux, F.; Linder, O.; van de Plassche, K.; Strand, P.; Szepesi, G.; Contributors, JET

2017-12-01

Quasilinear turbulent transport models are a successful tool for prediction of core tokamak plasma profiles in many regimes. Their success hinges on the reproduction of local nonlinear gyrokinetic fluxes. We focus on significant progress in the quasilinear gyrokinetic transport model QuaLiKiz (Bourdelle et al 2016 Plasma Phys. Control. Fusion 58 014036), which employs an approximated solution of the mode structures to significantly speed up computation time compared to full linear gyrokinetic solvers. Optimisation of the dispersion relation solution algorithm within integrated modelling applications leads to flux calculations × {10}6-7 faster than local nonlinear simulations. This allows tractable simulation of flux-driven dynamic profile evolution including all transport channels: ion and electron heat, main particles, impurities, and momentum. Furthermore, QuaLiKiz now includes the impact of rotation and temperature anisotropy induced poloidal asymmetry on heavy impurity transport, important for W-transport applications. Application within the JETTO integrated modelling code results in 1 s of JET plasma simulation within 10 h using 10 CPUs. Simultaneous predictions of core density, temperature, and toroidal rotation profiles for both JET hybrid and baseline experiments are presented, covering both ion and electron turbulence scales. The simulations are successfully compared to measured profiles, with agreement mostly in the 5%-25% range according to standard figures of merit. QuaLiKiz is now open source and available at www.qualikiz.com.

Die Arbeitsgruppe der deutschen Handschriftenzentren - Servicezentren für Handschriftenerschließung und -digitalisierung

Directory of Open Access Journals (Sweden)

Christoph Mackert

2015-03-01

Full Text Available Mit sechs Handschriftenzentren verfügt Deutschland über eine weltweit einmalige Forschungsinfrastruktur zur Erschließung und zunehmend auch Digitalisierung des mittelalterlichen Handschriftenerbes. Der Beitrag stellt die Organisation, Funktion und Serviceangebote der Handschriftenzentren vor. The six German manuscript centers are a globally unique research infrastructure for cataloguing and increasingly for digitization of the medieval manuscript heritage. The paper presents the organization, function and services of the manuscript centers.

Parity violation constraints using cosmic microwave background polarization spectra from 2006 and 2007 observations by the QUaD polarimeter.

Science.gov (United States)

Wu, E Y S; Ade, P; Bock, J; Bowden, M; Brown, M L; Cahill, G; Castro, P G; Church, S; Culverhouse, T; Friedman, R B; Ganga, K; Gear, W K; Gupta, S; Hinderks, J; Kovac, J; Lange, A E; Leitch, E; Melhuish, S J; Memari, Y; Murphy, J A; Orlando, A; Piccirillo, L; Pryke, C; Rajguru, N; Rusholme, B; Schwarz, R; O'Sullivan, C; Taylor, A N; Thompson, K L; Turner, A H; Zemcov, M

2009-04-24

We constrain parity-violating interactions to the surface of last scattering using spectra from the QUaD experiment's second and third seasons of observations by searching for a possible systematic rotation of the polarization directions of cosmic microwave background photons. We measure the rotation angle due to such a possible "cosmological birefringence" to be 0.55 degrees +/-0.82 degrees (random) +/-0.5 degrees (systematic) using QUaD's 100 and 150 GHz temperature-curl and gradient-curl spectra over the spectra over the multipole range 200

The Quantitative Reasoning for College Science (QuaRCS) Assessment: Emerging Themes from 5 Years of Data

Science.gov (United States)

Follette, Katherine; Dokter, Erin; Buxner, Sanlyn

2018-01-01

The Quantitative Reasoning for College Science (QuaRCS) Assessment is a validated assessment instrument that was designed to measure changes in students' quantitative reasoning skills, attitudes toward mathematics, and ability to accurately assess their own quantitative abilities. It has been administered to more than 5,000 students at a variety of institutions at the start and end of a semester of general education college science instruction. I will begin by briefly summarizing our published work surrounding validation of the instrument and identification of underlying attitudinal factors (composite variables identified via factor analysis) that predict 50% of the variation in students' scores on the assessment. I will then discuss more recent unpublished work, including: (1) Development and validation of an abbreviated version of the assessment (The QuaRCS Light), which results in marked improvements in students' ability to maintain a high effort level throughout the assessment and has broad implications for quantitative reasoning assessments in general, and (2) Our efforts to revise the attitudinal portion of the assessment to better assess math anxiety level, another key factor in student performance on numerical assessments.

QuaDoSta - a freely configurable system which facilitates multi-centric data collection for healthcare and medical research

Directory of Open Access Journals (Sweden)

Albrecht, Ulrike

2007-07-01

Full Text Available This article describes QuaDoSta (quality assurance, documentation and statistics, a flexible documentation system as well as a data collection and networking platform for medical facilities. The user can freely define the required documentation masks which are easily expandable and can be adapted to individual requirements without the need for additional programming. To avoid duplication, data transfer interfaces can be configured flexibly to external sources such as patient management systems used in surgeries or hospital information systems. The projects EvaMed (Evaluation Anthroposophical Medicine and the Network Oncology are two scientific research projects which have been successfully established as nationally active networks on the basis of QuaDoSta. The EvaMed-Network serves as a modern pharmacovigilance project for the documentation of adverse drug events. All prescription data are electronically recorded to assess the relative risk of drugs. The Network Oncology was set up as a documentation system in four hospitals and seven specialist oncology practices where a complete record of all oncological therapies is being carried out to uniform standards on the basis of the ‘basic documentation for tumour patients’ (BDT developed by the German Cancer Society. The QuaDoSta solution system made it possible to cater for the specific requirements of the presented projects. The following features of the system proved to be highly advantageous: flexible setup of catalogues and user friendly customisation and extensions, complete dissociation of system setup and documentation content, multi-centre networkability, and configurable data transfer interfaces.

En evaluering af projektet 'bib:talk unge mødes' på Ballerup Bibliotek

DEFF Research Database (Denmark)

Khawaja, Iram; Staunæs, Dorthe

2007-01-01

På Ballerup Bibliotekerne blev ord som integration og gensidig forståelse omsat til praktisk handling i 2006. Med økonomisk støtte fra Biblioteksstyrelsens udviklingspulje for skole- og folkebiblioteker kørte Ballerup Bibliotekerne i efteråret et dialogprojekt "Unge mødes og dialog opstår. Vores ...... opbygget, har løftet BIB:talk-projektets kvalitet markant. Opbakningen fra resten af personalet på biblioteket har været fantastisk og alle har følt ejerskab til projektet....

Recurrent modulation of galactic cosmic ray electrons and protons: Ulysses COSPIN/KET observations

International Nuclear Information System (INIS)

Heber, B.; Blake, J.B.; Paizis, C.; Bothmer, V.; Kunow, H.; Wibberenz, G.; Burger, R.A.; Potgieter, M.S.

2000-01-01

Since measurements of space probes in the interplanetary space became available it has been known that associated with the occurrence of recurrent fast and slow solar wind streams, forming Corotating Interaction Regions, recurrent variations in the cosmic ray nuclei flux are observed. As pointed out recently by Jokipii and Kota (2) recurrent modulation for positively and negatively charged particles may be different. In the time interval extending from July 1992 to July 1994, Ulysses on its journey to high heliographic latitudes registered ∼20 stable and long-lasting Corotating Interaction Regions (CIRs). In this work we use data from the Cosmic Ray and Solar Particle Investigation Kiel Electron Telescope (COSPIN/KET) instrument on board Ulysses to study the recurrent variation of 2.5 GV electrons and protons. We find that 1) electrons are indeed periodically modulated, but that 2) the periodicity of ∼29 days is longer than the period of ∼26 days for protons, and that 3) the amplitude is larger than the one observed for protons

C → T mutagenesis and γ-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases

Science.gov (United States)

An, Qian; Robins, Peter; Lindahl, Tomas; Barnes, Deborah E

2005-01-01

The most common genetic change in aerobic organisms is a C:G to T:A mutation. C → T transitions can arise through spontaneous hydrolytic deamination of cytosine to give a miscoding uracil residue. This is also a frequent DNA lesion induced by oxidative damage, through exposure to agents such as ionizing radiation, or from endogenous sources that are implicated in the aetiology of degenerative diseases, ageing and cancer. The Ung and Smug1 enzymes excise uracil from DNA to effect repair in mammalian cells, and gene-targeted Ung−/− mice exhibit a moderate increase in genome-wide spontaneous mutagenesis. Here, we report that stable siRNA-mediated silencing of Smug1 in mouse embryo fibroblasts also generates a mutator phenotype. However, an additive 10-fold increase in spontaneous C:G to T:A transitions in cells deficient in both Smug1 and Ung demonstrates that these enzymes have distinct and nonredundant roles in suppressing C → T mutability at non-CpG sites. Such cells are also hypersensitive to ionizing radiation, and reveal a role of Smug1 in the repair of lesions generated by oxidation of cytosine. PMID:15902269

Ungüento ZZ, antiséptico elaborado con una zeolita natural modificada

Directory of Open Access Journals (Sweden)

Iliana Perdomo López

1998-12-01

Full Text Available Se realizó el diseño del ungüento ZZ a partir del producto activo zeolítico ZZ, el cual posee una marcada actividad antimicrobiana en el tratamiento de las micosis y afecciones bacterianas. Se elaboraron 3 formulaciones las cuales se evaluaron mediante determinaciones físico-químicas. La formulación I respondió a la utilización del ungüento hidrófilo como base, la II a la crema secante y la III a una base emulsionada aceite en agua. Se obtuvo como resultado la no utilización de las formulaciones I y II por la interacción del principio activo con el laurilsulfato de sodio y con el monoestearato de glicerilo, respectivamente. La formulación III resultó muy adecuada desde el punto de vista tecnológico y se le realizaron estudios toxicológicos de irritabilidad dérmica que resultaron favorables, ya que no hubo irritación de las zonas tratadas.ZZ oinment was designed from an active zeolite product which has a marked antimicrobial effect in the treatment of micosis and bacterial affections. Three different formulations were evaluated for the product through physicial-chemical determinations. Formulation I used hidrophil oinment as a base; formulation II used drying cream and Formulation III chose an oil-in-water emulsified base. As a result of this assessment, formulations I and II were not chosen because of the interaction of the active agent with sodium laurylsulphate and with glyceril monostereate respectively. Formulation III turned out to be the most suitable from the technological viewpoint. Toxicological studies were performed on this formulation to observe skin irritability but the results were favourable since there was no trace of irritation in the treated areas.

Utilización de quitina en formas farmacéuticas: I Ungüento

OpenAIRE

Ofelia Bilbao Revoredo; Sol A Fernández Monagas; Olga M Nieto Acosta; Ruth D Henríques Rodríguez

1998-01-01

Se realizó un estudio tecnológico en la forma farmacéutica ungüento, para lo cual se empleó quitina como principio activo. Se utilizaron 2 tipos de base, oleosa e hidrosoluble, la primera con mejores características. Se estudiaron la liberación in vitro del fármaco, así como la cinética de este proceso, y se llegó a la conclusión de que el mayor porcentaje de quitina liberada fue en base oleosa. Se siguió en ambos casos una cinética de orden cero.A technological study of pharmaceutical form o...

Der er faresignaler her - om ret og heuristik i det almindelige, kommunale tilsyn med børn og unge

DEFF Research Database (Denmark)

Svendsen, Idamarie Leth

2014-01-01

KORT RESUME Kommunerne underlægges i stigende grad krav om at føre et aktivt og opsøgende tilsyn med børn og unge. Kravene fremgår af serviceloven med tilhørende forskrifter. Disse regler har sammenhæng med en række andre regler på det sociale og velfærdsretlige område i øvrigt, men også med forv...

Evolution of cosmic ray fluxes during the rising phase of solar cycle 23: ULYSSES EPAC and COSPIN/KET observations

International Nuclear Information System (INIS)

Heber, B.; Keppler, E.; Blake, J.B.; Fraenz, M.; Kunow, H.

2000-01-01

Galactic cosmic rays are entering the heliosphere from the interstellar medium, while anomalous cosmic rays are believed to be pickup ions accelerated at the heliospheric termination shock. Both particle species are modulated by the solar wind and the heliospheric magnetic field. Since 1997 solar activity increased and as a consequence the flux of galactic and anomalous cosmic ray decreased. In this paper we will discuss the variation of low energy anomalous cosmic rays as measured by the Ulysses Energetic Particle Composition Experiment (EPAC) and the Kiel Electron Telescope (KET) on board Ulysses. Specifically we are addressing the question: Are there differences in the modulation of galactic and anomalous cosmic rays and what are possible implication for the modulation of cosmic rays in the heliosphere?

Geborgenheid as ’n sine qua non vir opvoedende onderwys

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I.J. Oosthuizen

2001-08-01

Full Text Available Security as a sine qua non for education Learner security is an imperative for education. Whereas an environment of security is conducive to learning, the absence of it is destructive of effective learning. Some of the factors that are to be taken into account in order to create a sound environment of security for the learner are the following: • the physical well-being of the learner; • the mental well-being of the learner liberated from anxiety and fear and • the competence and proficiency of the teacher. In many respects contemporary South African education is characterised by an absence of security and surity. Some of the reasons for this situation are instances of physical and mental insecurity such as a prevailing culture of physical violence, drug abuse and an alarming rise of contagious diseases in schools. This article focuses on these and other factors responsible for instances of an insecure learning environment in South African education. This article also seeks to find possible solutions towards securing the learning environment of the learner.

Sociale netværkssider og digital ungdomskultur: Når unge praktiserer venskab på nettet [Social Network Sites and Digital Youth Culture: When young people practice friendship online

Directory of Open Access Journals (Sweden)

Malene Charlotte Larsen

2009-02-01

Full Text Available Arto, Facebook og MySpace er nogle af de internetfællesskaber, som flere hundredtusinde danskere i løbet af ganske få år har oprettet profiler på. Med fremkomsten og populariseringen af disse hjemmesider er opstået et nyt mediebegreb: sociale netværkssider (eller på engelsk: social network(ing sites. Som det oftest er tilfældet med nye medier, har teenagere være de første til at tage sociale netværkssider til sig. Med denne artikel har jeg til hensigt at beskrive, hvad sociale netværkssider er, samt hvordan de anvendes som en del af ungdomsgenerationens hverdagsliv til vedligeholdelse af sociale relationer. Dette gør jeg ved dels at præsentere en række begreber, som jeg mener er vigtige at forstå i forhold til unges brug af sociale netværk. Og dels vil jeg fremhæve nogle resultater fra min egen forskning i 12-18-årige børn og unges brug af forskellige sociale netværk, heriblandt Arto.com, som længe har været de danske teenageres foretrukne mødested på nettet. Ud fra empiriske eksempler diskuterer jeg således, hvordan sociale netværkssider indgår som en integreret del af de unge brugeres venskaber og sociale liv. Artiklen bygger på fire års etnografiske undersøgelser.

Sociale netværkssider og digital ungdomskultur: Når unge praktiserer venskab på nettet [Social Network Sites and Digital Youth Culture: When young people practice friendship online

Directory of Open Access Journals (Sweden)

Malene Charlotte Larsen

2009-12-01

Full Text Available Arto, Facebook og MySpace er nogle af de internetfællesskaber, som flere hundredtusinde danskere i løbet af ganske få år har oprettet profiler på. Med fremkomsten og populariseringen af disse hjemmesider er opstået et nyt mediebegreb: sociale netværkssider (eller på engelsk: social network(ing sites. Som det oftest er tilfældet med nye medier, har teenagere være de første til at tage sociale netværkssider til sig. Med denne artikel har jeg til hensigt at beskrive, hvad sociale netværkssider er, samt hvordan de anvendes som en del af ungdomsgenerationens hverdagsliv til vedligeholdelse af sociale relationer. Dette gør jeg ved dels at præsentere en række begreber, som jeg mener er vigtige at forstå i forhold til unges brug af sociale netværk. Og dels vil jeg fremhæve nogle resultater fra min egen forskning i 12-18-årige børn og unges brug af forskellige sociale netværk, heriblandt Arto.com, som længe har været de danske teenageres foretrukne mødested på nettet. Ud fra empiriske eksempler diskuterer jeg således, hvordan sociale netværkssider indgår som en integreret del af de unge brugeres venskaber og sociale liv. Artiklen bygger på fire års etnografiske undersøgelser.

Computerunterstützte Sacherschließung mit dem Digitalen Assistenten (DA-2

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Imma Hinrichs

2016-12-01

Full Text Available Wir beschreiben den Digitalen Assistenten DA-2, den wir zur Unterstützung der Sacherschliessung im IBS-Verbund implementiert haben. Diese webbasierte Anwendung ist eine vollständige Neuimplementierung, welche die Erkenntnisse des Vorgängersystems bei der Zentralbibliothek Zürich berücksichtigt. Wir stellen Überlegungen zur Zukunft der Sacherschliessung an und geben eine Übersicht über Projekte mit ähnlichen Zielsetzungen, die Sacherschließung mit Computerunterstützung effizienter und besser zu gestalten.   We describe the digital assistant DA-2 which we have implemented to support the subject indexing process in the IBS-Verbund. This web-based service is a new implementation from scratch based on the lessons learned with its predecessor used by the Zentralbibliothek Zürich. We also discuss the future of intellectual subject indexing and we give an overview on related projects also aiming at digitizing and economizing this challenging process.

Emotional intelligence: the Sine Qua Non for a clinical leadership toolbox.

Science.gov (United States)

Rao, Paul R

2006-01-01

Over the past decade, it has become increasingly clear that although IQ and technical skills are important, emotional intelligence is the Sine Qua Non of leadership. According to Goleman [Goleman, D. (1998). What makes a leader? Harvard Business Review, 93-102] "effective leaders are alike in one crucial way: they all have a high degree of emotional intelligence...and can also be linked to strong performance." The original five dimensions of EIQ are described and applied to both supervisory and clinical scenarios. As a result of reading this work, you will be able to: (1) define and provide an illustration of each of the five components of emotional intelligence (EIQ); (2) outline the relationship of EIQ to success in your profession and your personal life; (3) create a strategic action plan to enhance each dimension of EIQ in your daily life; (4) list at least three real-life experiences that could have resulted a favorable outcome with an improved EIQ; (5) complete a self-evaluation of your EIQ.

Pegada Ecológica: uma ferramenta utilizada como indicador e conscientizador do consumo, aplicado na UNG Universidade, Guarulhos/SP

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Regina de Oliveira Moraes Arruda

2017-05-01

Full Text Available Among the functions of a university there are Teaching, Research and Extension. In order to collaborate in the extension of actions within the week of Conscious Consumption, 2016, Master in Geoenvironmental Analysis at the UNG Universidade suggested the questionnaire on the Ecological Footprint, an instrument that was developed and widely publicized by the WWF-Brazil (World Wide Fund for Nature - Brazil. The shares were held in the three campuses in the University: Center, Dutra and Itaquaquecetuba, covering about 1,000 students. Students answered the questionnaire with 18 questions and after the addition of the points, these might be classified according to the amount of renewable natural resources to maintain their standard of living and how many planets would be needed to keep this consumption if all people on the planet I had the same level of consumption. With the result of the application of this questionnaire, we can see that the students of the UNG Universidade need, on average, 2.8 planets to maintain its consumption of life, higher than the national average which is 1.6 and very close to average the UK is 3.0. When it comes to Conscious Consumption it is important each person doing the exercise to quantify and reflect on their lifestyle. Thus, this extension activity fulfilled its objectives, since the discussion on consumption was noticeable by observing the students talking and checking how are consumerist and Consumer Awareness is not limited to “shopping” but also housing, food, waste and transportation.

Out-of-ecliptic quiet time MeV electron increases: Ulysses COSPIN/KET observations

International Nuclear Information System (INIS)

Heber, B.; Ferreira, S.E.S.; Potgieter, M.S.; Henize, V.K.; Moeketsi, D.M.; Fichtner, H.; Kissmann, R.

2004-01-01

The propagation of cosmic rays in turbulent magnetic fields can be studied in detail by way of in-situ measurements of energetic particles in the three-dimensional heliosphere. Measurements of 3-20 MeV electrons from 1990 to 2003 have been made by the Kiel Electron Telescope (KET) onboard the Ulysses spacecraft during varying solar conditions. In order to interpret these measurements, it is necessary to distinguish between solar, galactic and Jovian electrons and to investigate their propagation, by using sophisticated particle propagation models. The solar contribution to the MeV electron intensities can be excluded by analyzing the electron energy spectra and the nuclei time histories. The residual electron intensities can be reasonably described by modulation models taking into account galactic cosmic rays as well as Jovian electrons using different diffusion coefficients for solar minimum and maximum. The way in which the relative contribution of Jovian (point source in the ecliptic) and galactic electrons (isotropic source) varies along the Ulysses orbit is strongly dependent on the choice of these coefficients. Since the 1970's quiet time electron increases have been observed in the ecliptic and interpreted as Jovian electron increases. Therefore, the occurrence of such quiet time electron increases is an indicator for a dominant Jovian contribution to the measured MeV electron intensities. At solar minimum and maximum such events have been observed up to ∼30 deg. and ∼45 deg. These observations are crucial for a determination of the diffusion parameters. At solar maximum a more efficient latitude transport is needed to account for the electron intensity variations

Quantitative structure-activity relationships of selective antagonists of glucagon receptor using QuaSAR descriptors.

Science.gov (United States)

Manoj Kumar, Palanivelu; Karthikeyan, Chandrabose; Hari Narayana Moorthy, Narayana Subbiah; Trivedi, Piyush

2006-11-01

In the present paper, quantitative structure activity relationship (QSAR) approach was applied to understand the affinity and selectivity of a novel series of triaryl imidazole derivatives towards glucagon receptor. Statistically significant and highly predictive QSARs were derived for glucagon receptor inhibition by triaryl imidazoles using QuaSAR descriptors of molecular operating environment (MOE) employing computer-assisted multiple regression procedure. The generated QSAR models revealed that factors related to hydrophobicity, molecular shape and geometry predominantly influences glucagon receptor binding affinity of the triaryl imidazoles indicating the relevance of shape specific steric interactions between the molecule and the receptor. Further, QSAR models formulated for selective inhibition of glucagon receptor over p38 mitogen activated protein (MAP) kinase of the compounds in the series highlights that the same structural features, which influence the glucagon receptor affinity, also contribute to their selective inhibition.

The OSU1/QUA2/TSD2-encoded putative methyltransferase is a critical modulator of carbon and nitrogen nutrient balance response in Arabidopsis.

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Peng Gao

2008-01-01

Full Text Available The balance between carbon (C and nitrogen (N nutrients must be tightly coordinated so that cells can optimize their opportunity for metabolism, growth and development. However, the C and N nutrient balance perception and signaling mechanism remains poorly understood. Here, we report the isolation and characterization of two allelic oversensitive to sugar 1 mutants (osu1-1, osu1-2 in Arabidopsis thaliana. Using the cotyledon anthocyanin accumulation and root growth inhibition assays, we show that the osu1 mutants are more sensitive than wild-type to both of the imbalanced C/N conditions, high C/low N and low C/high N. However, under the balanced C/N conditions (low C/low N or high C/high N, the osu1 mutants have similar anthocyanin levels and root lengths as wild-type. Consistently, the genes encoding two MYB transcription factors (MYB75 and MYB90 and an Asn synthetase isoform (ASN1 are strongly up-regulated by the OSU1 mutation in response to high C/low N and low C/high N, respectively. Furthermore, the enhanced sensitivity of osu1-1 to high C/low N with respect to anthocyanin accumulation but not root growth inhibition can be suppressed by co-suppression of MYB75, indicating that MYB75 acts downstream of OSU1 in the high C/low N imbalance response. Map-based cloning reveals that OSU1 encodes a member of a large family of putative methyltransferases and is allelic to the recently reported QUA2/TSD2 locus identified in genetic screens for cell-adhesion-defective mutants. Accumulation of OSU1/QUA2/TSD2 transcript was not regulated by C and N balance, but the OSU1 promoter was slightly more active in the vascular system. Taken together, our results show that the OSU1/QUA2/TSD2-encoded putative methyltransferase is required for normal C/N nutrient balance response in plants.

Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.

Science.gov (United States)

Arif, S M; Geethanandan, K; Mishra, P; Surolia, A; Varshney, U; Vijayan, M

2015-07-01

17 independent crystal structures of family I uracil-DNA glycosylase from Mycobacterium tuberculosis (MtUng) and its complexes with uracil and its derivatives, distributed among five distinct crystal forms, have been determined. Thermodynamic parameters of binding in the complexes have been measured using isothermal titration calorimetry. The two-domain protein exhibits open and closed conformations, suggesting that the closure of the domain on DNA binding involves conformational selection. Segmental mobility in the enzyme molecule is confined to a 32-residue stretch which plays a major role in DNA binding. Uracil and its derivatives can bind to the protein in two possible orientations. Only one of them is possible when there is a bulky substituent at the 5' position. The crystal structures of the complexes provide a reasonable rationale for the observed thermodynamic parameters. In addition to providing fresh insights into the structure, plasticity and interactions of the protein molecule, the results of the present investigation provide a platform for structure-based inhibitor design.

Spatial gradients of GCR protons in the inner heliosphere derived from Ulysses COSPIN/KET and PAMELA measurements

Science.gov (United States)

Gieseler, J.; Heber, B.

2016-05-01

Context. During the transition from solar cycle 23 to 24 from 2006 to 2009, the Sun was in an unusual solar minimum with very low activity over a long period. These exceptional conditions included a very low interplanetary magnetic field (IMF) strength and a high tilt angle, which both play an important role in the modulation of galactic cosmic rays (GCR) in the heliosphere. Thus, the radial and latitudinal gradients of GCRs are very much expected to depend not only on the solar magnetic epoch, but also on the overall modulation level. Aims: We determine the non-local radial and the latitudinal gradients of protons in the rigidity range from ~0.45 to 2 GV. Methods: This was accomplished by using data from the satellite-borne experiment Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) at Earth and the Kiel Electron Telescope (KET) onboard Ulysses on its highly inclined Keplerian orbit around the Sun with the aphelion at Jupiter's orbit. Results: In comparison to the previous A> 0 solar magnetic epoch, we find that the absolute value of the latitudinal gradient is lower at higher and higher at lower rigidities. This energy dependence is therefore a crucial test for models that describe the cosmic ray transport in the inner heliosphere.

„Perché sono tutti cattivi“: Strategien der Anziehung und Abstoßung in ‚Gomorra – la serie‘

Directory of Open Access Journals (Sweden)

Tanja Weber

2015-05-01

Full Text Available Der Pay-TV Sender Sky Italia sendet neben Sport vor allem US-amerikanische Fernsehserien, die als Quality TV bezeichnet werden. Inzwischen produziert er auch eigene Serien, die international konkurrenzfähig sein sollen. Dabei setzt er auch bei seiner dritten Produktion Gomorra – La serie auf transmediales Erzählen als Risikominimierungsstrategie, das heißt, der Serie gehen ein erfolgreiches Buch und ein Film voraus. Gomorra – La serie setzt sich darüber hinaus mit der italienischen Tradition, das organisierte Verbrechen darzustellen, auseinander. Dies schlägt sich vor allem in der Figurenzeichnung nieder und führt zu außergewöhnlichen Strategien der Anziehung und Abstoßung.

Utilización de quitina en formas farmacéuticas: I Ungüento

Directory of Open Access Journals (Sweden)

Ofelia Bilbao Revoredo

1998-12-01

Full Text Available Se realizó un estudio tecnológico en la forma farmacéutica ungüento, para lo cual se empleó quitina como principio activo. Se utilizaron 2 tipos de base, oleosa e hidrosoluble, la primera con mejores características. Se estudiaron la liberación in vitro del fármaco, así como la cinética de este proceso, y se llegó a la conclusión de que el mayor porcentaje de quitina liberada fue en base oleosa. Se siguió en ambos casos una cinética de orden cero.A technological study of pharmaceutical form ointment was undertaken for which chitin was used as an active agent. Two types of base were used: oinment and water-soluble; the former presented better characteristics. Drug release in vitro and the kinetics of this process were studied so it was concluded that the higher percentage of chitin was released in oinment. Zero kinetics was followed in both cases.

Betydningen av drektige reinsimlers ernæring for kalvers vekst, klimatiske toleranse og overlevelse

Directory of Open Access Journals (Sweden)

Arne Rognmo

2013-03-01

Full Text Available Forsøkene (viste at tilleggsforing av underernærte simler i siste del av drektighetsperioden kun synes å ha effekt på fødselsvekten for kalvene forutsatt at simlene får høyverdig ernæring etter kalving. Den forskjellige ernæringsbakgrunn før kalving synes således ikke å innvirke på melkeproduksjon/kvalitet, da vektutviklingen for alle grupper av kalver i dette forsøket gikk parallelt i de tre første ukene etter kalving. Det ble heller ikke på noe punkt funnet signifikante forskjeller gruppene imellom når det gjelder kalvenes klimatiske toleranse. Det er dog bemerkelsesverdig at det var stor dødelighet blant de små kalvene etter unge små simler i GRUPPE L. Dette funn er interessant sett i sammenheng med resultatene fra Røros (se bidrag fra Dag Lenvik, side som viser at avkastningen fra en flokk kan økes markant om man konsentrerte slakteuttaket på små kalver og forhindrer bedekning av små, unge simler gjennom fjerning av eldre, store bukker. Med det forbehold at våre forsøk er utført på dyr i innhegning med et lavt aktivitetsnivå, kan man fra våreforsøk foreløpig konkludere med at tillegsfor ing av simler i siste halvdel av drektighetsperioden har effekt på kalvenes fødselsvekt, men at vektutviklingen for kalven er uavhengig av simlenes ernæringshistorie, om sistnevnte tilbys høyverdig ernæring etter kalving. Da små kalver etter underernærte simler viste høy dødelighet like etter fødselen, vil imidlertid tilleggsforing kunne øke avkastningen om det er mange unge simler i flokken. Resultatene fra Røros tyder imidlertid på at dette resultat normalt kan oppnås uten ekstra omkostninger gjennom et selektivt slakteuttak.

Ocular pharmacokinetics of topically-applied ketoconazole solution containing hydroxypropyl beta-cyclodextrin to rabbits.

Science.gov (United States)

Zhang, Junjie; Wang, Liya; Gao, Changfeng; Zhang, Li; Xia, Huiyun

2008-10-01

The aim of this study was to develop an aqueous ketoconazole (KET) eye drop in order to increase the corneal permeability and improve ocular bioavailability following topical application. Hydroxypropyl beta-cyclodextrin (HP-beta-CD) was used to formulate an aqueous eye drop to improve the aqueous solubility of KET. A single dose of of either KET suspension (1.5%; KET-SP) or KET (1.5%)/HP-beta -CD (12.5%) solution (KET-CD) was applied to rabbits. Aqueous humor and cornea were collected after 5, 10, 20, 30, 45, 60, 90, 120, and 180 min. KET concentrations were determined by high-performance liquid chromatography after extraction. After topically applying KET-CD, the KET concentrations in aqueous humor were significantly increased at 10 approximately 120 min, compared with those of KET-SP (P cornea (118.24 microg/g) was achieved within 5 min after the instillation of KET-CD, 18.4 times higher than that of KET-SP at the same time point, whereas the highest KET level in cornea was only 8.57 microg/g after a 10-min application of KET-SP. The KET levels in corneas obtained after the application of KET-CD were all much higher than those obtained by KETSP (P corneas over the KET-SP.

”Har du ikke en bra feed på Insta, så har du ikke orden på livet ditt!” Unge jenter sin opplevelse av andres selvrepresentasjon i bildedelingstjenester.

OpenAIRE

Magnussen, Andrea Bergum

2017-01-01

Mastergradsoppgave i digital kommunikasjon og kultur, Avdeling for lærerutdanning og naturvitenskap, Høgskolen i Innlandet, 2017 Norsk: Denne oppgaven undersøker unge jenters opplevelse av selvrepresentasjonen på bildedelingstjenestene Instagram og Snapchat. Funnene er basert på individuelle intervjuer og et fokusgruppeintervju av fem jenter på 14 år. Intervjupersonene har i hovedsak uttrykt seg om deres opplevelse knyttet til kjendiser og influencers sin selvrepresentasjon. Oppgaven ta...

Synergetic skin targeting effect of hydroxypropyl-β-cyclodextrin combined with microemulsion for ketoconazole.

Science.gov (United States)

Che, Junxiu; Wu, Zushuai; Shao, Weiyan; Guo, Penghao; Lin, Yuanyuan; Pan, Wenhui; Zeng, Weidong; Zhang, Guoguang; Wu, Chuanbin; Xu, Yuehong

2015-06-01

The objective was to develop a ternary skin targeting system for ketoconazole (KET) using a combined strategy of microemulsion (ME) and cyclodextrin (HP-β-CD), i.e., KET-CD-ME, which exploits both virtues of cyclodextrin complex and ME to obtain the synergetic effect. KET-CD-ME was formulated using Labrafil M 1944 CS as oil phase, Solutol HS 15 as surfactant, Transcutol P as cosurfactant, and HP-β-CD solution as aqueous phase. The formulation of KET-CD-ME was optimized and the optimal formulation was characterized in terms of particle size, size distribution, pH value, and viscosity. Long term stability experiment showed that HP-β-CD could increase the physical stability of ternary system and KET chemical stability. Percutaneous permeation of KET from KET-CD-ME in vitro through rat skin was investigated in comparison with KET microemulsion (KET-ME), KET HP-β-CD inclusion solution (KET-CD), KET aqueous suspension, and commercial KET cream; the results showed that the combination of ME with HP-β-CD exhibited significantly synergistic effect on KET deposition within the skin (29.38 ± 1.79 μg/cm(2)) and a slightly synergistic effect on KET penetration through the skin (11.3 μg/cm(2)/h). The enhancement of the combination on skin deposition was further visualized by confocal laser scanning microscope (CLSM). In vitro sensitivity against Candida parapsilosis test indicated that KET-CD-ME enhanced KET antifungal activity mainly owing to the solubilization of HP-β-CD on KET in the ternary system. Moreover, the interactions between HP-β-CD and KET in the ternary system were elucidated through microScale thermophoresis (MST) and 2D (1)H NMR spectroscopy. The profiles from MST confirmed the host-guest interactions of HP-β-CD with KET in the ternary system and a deep insight into the interactions between KET and HP-β-CD were obtained by means of 2D (1)H NMR spectroscopy. The results indicate that the ternary system of ME combination with HP-β-CD may be a promising

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor.

Directory of Open Access Journals (Sweden)

Aneta Novotna

Full Text Available Azole antifungal ketoconazole (KET was demonstrated to activate aryl hydrocarbon receptor (AhR. Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S-(+-KET and (2S,4R-(--KET, we examined the effects of KET enantiomers on AhR signaling pathway. (+-KET dose-dependently activated AhR in human gene reporter cell line AZ-AHR, and displayed 5-20× higher agonist activity (efficacy, as compared to (--KET; both enantiomers were AhR antagonists with equal potency (IC50. Consistently, (+-KET strongly induced CYP1A1 mRNA and protein in human HepG2 cells, while (--KET exerted less than 10% of (+-KET activity. In primary human hepatocytes, both enantiomers preferentially induced CYP1A2 over CYP1A1 mRNA and protein, and the potency of (+-KET was slightly higher as compared to (--KET. Ligand binding assay with guinea pig liver cytosols revealed that both (+-KET and (--KET are weak ligands of AhR that displaced [3H]-TCDD with comparable potency. Similarly, both enantiomers weakly transformed AhR to DNA-binding form with similar potency, as showed by EMSA, in guinea pig liver cytosolic extracts and nuclear extracts from mouse Hepa-1 cells. We also examined effects of KET on glucocorticoid receptor (GR, a regulator of AhR activity. Both KET enantiomers antagonized GR with similar potency, as revealed by gene reporter assay in AZ-GR cell line and down-regulation of tyrosine aminotransferase mRNA in human hepatocytes. Finally, we demonstrate enantiospecific antifungal activities of KET enantiomers in six Candida spp. strains. In conclusion, the significance of current study is providing the first evidence of enatiospecific effects of cis-enantiomers of ketoconazole on AhR-CYP1A pathway.

Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats.

Science.gov (United States)

Alirezaei, Masoud; Rezaei, Maryam; Hajighahramani, Shahin; Sookhtehzari, Ali; Kiani, Katayoun

2017-01-01

The present study was designed to evaluate the antioxidant effects of oleuropein against oxidative stress in the hippocampal area of rats. We used seven experimental groups as follows: Control, Propofol, Propofol-Ketamine (Pro.-Ket.), Xylazine-Ketamine (Xyl.-Ket.), and three oleuropein-pretreated groups (Ole.-Pro., Ole.-Pro.-Ket. and Ole.-Xyl.-Ket.). The oleuropein-pretreated groups received oleuropein (15 mg/kg body weight as orally) for 10 consecutive days. Propofol 100 mg/kg, xylazine 3 mg/kg, and ketamine 75 mg/kg once as ip was used on the 11th day of treatment. Spatial memory impairment and antioxidant status of hippocampus were measured via Morris water maze, lipid peroxidation marker, and antioxidant enzyme activities. Spatial memory impairment and lipid peroxidation significantly increased in Xyl.-Ket.-treated rats in comparison to the control, propofol, Ole.-Pro. and Ole.-Pro.-Ket. groups. Oleuropein pretreatment significantly reversed spatial memory impairment and lipid peroxidation in the Ole.-Xyl.-Ket. group as compared to the Xyl.-Ket.-treated rats. There was no significant difference between the control and the propofol group in lipid peroxidation and spatial memory status. Superoxide dismutase and catalase activities both significantly decreased in Xyl.-Ket.-treated rats when compared to the control, propofol, Ole.-Pro., Ole.-Pro.-Ket., and Ole.-Xyl.-Ket. groups. In contrast, glutathione peroxidase activity in Xyl.-Ket.-treated rats significantly increased as compared to the control, propofol, Pro.-Ket., Ole.-Pro., and Ole.-Pro.-Ket. groups. We concluded that xylazine in combination with ketamine is an oxidative anesthetic drug and oleuropein pretreatment attenuates cognitive dysfunction and oxidative stress induced by anesthesia in the hippocampal area of rats. We also confirmed the antioxidant properties of propofol as a promising antioxidant anesthetic agent.

6 belysninger af vejledning

DEFF Research Database (Denmark)

Toft, Helle Mary; Jessing, Carla Tønder; Nymann, Anette

Artiklerne belyser vejledning af unge og vejledning af voksne. I relation til unge drejer det sig om: 1. vejledning af unge med vanskeligheder i forhold til uddannelse - her unge med særlige vejledningsbehov, og mentorordninger for unge, og 2. vejledning af unge i ungdomsuddannelser og i erhvervs...

A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.

Science.gov (United States)

Moaddel, Ruin; Venkata, Swarajya Lakshmi Vattem; Tanga, Mary J; Bupp, James E; Green, Carol E; Iyer, Lalitha; Furimsky, Anna; Goldberg, Michael E; Torjman, Marc C; Wainer, Irving W

2010-10-15

A parallel chiral/achiral LC-MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in complex regional pain syndrome (CRPS) patients receiving a 5-day continuous infusion of a sub-anesthetic dose of (R,S)-Ket. The method was also validated for the determination of the enantiomers of the Ket metabolites norketamine, (R)- and (S)-norKet and dehydronorketamine, (R)- and (S)-DHNK, as well as the diastereomeric metabolites hydroxynorketamine, (2S,6S)-/(2R,6R)-HNK and two hydroxyketamines, (2S,6S)-HKet and (2S,6R)-Hket. In this method, (R,S)-Ket, (R,S)-norKet and (R,S)-DHNK and the diastereomeric hydroxyl-metabolites were separated and quantified using a C(18) stationary phase and the relative enantiomeric concentrations of (R,S)-Ket, (R,S)-norKet and (R,S)-DHNK were determined using an AGP-CSP. The analysis of the results of microsomal incubations of (R)- and (S)-Ket and a plasma and urine sample from a CRPS patient indicated the presence of 10 additional compounds and glucuronides. The data from the analysis of the patient sample also demonstrated that a series of HNK metabolites were the primary metabolites in plasma and (R)- and (S)-DHNK were the major metabolites found in urine. The results suggest that norKet is the initial, but not the primary metabolite and that downstream norKet metabolites play a role in (R,S)-Ket-related pain relief in CRPS patients. Published by Elsevier B.V.

Hydrogel of Ketoconazole and PAMAM Dendrimers: Formulation and Antifungal Activity

Directory of Open Access Journals (Sweden)

Elzbieta Tryniszewska

2012-04-01

Full Text Available Ketoconazole (KET, an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate the influence of PAMAM-NH₂ and PAMAM-OH dendrimers generation 2 and generation 3 on the solubility and antifungal activity of KET and to design and evaluate KET hydrogel with PAMAM dendrimers. It was shown that the surface charge of PAMAM dendrimers strongly affects their influence on the improvement of solubility and antifungal activity of KET. The MIC and MFC values obtained by broth dilution method indicate that PAMAM-NH₂ dendrimers significantly (up to 16-fold increased the antifungal activity of KET against Candida strains (e.g., in culture Candida albicans 1103059/11 MIC value was 0.008 μg/mL and 0.064 μg/mL, and MFC was 2 μg/mL and 32 μg/mL for KET in 10 mg/mL solution of PAMAM-NH₂ G2 and pure KET, respectively. Antifungal activity of designed KET hydrogel with PAMAM-NH₂ dendrimers measured by the plate diffusion method was definitely higher than pure KET hydrogel and than commercial available product. It was shown that the improvement of solubility and in the consequence the higher KET release from hydrogels seems to be a very significant factor affecting antifungal activity of KET in hydrogels containing PAMAM dendrimers.

Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain.

Science.gov (United States)

Sawynok, Jana; Zinger, Celia

2016-01-01

Neuropathic pain (NP) has several therapeutic options but efficacy is limited and adverse effects occur, such that additional treatment options are needed. A topical formulation containing amitriptyline 4% and ketamine 2% (AmiKet) may provide such an option. This report summarizes both published and unpublished results of clinical trials with AmiKet. In post-herpetic neuralgia (PHN), AmiKet produces a significant analgesia which is comparable to that produced by oral gabapentin. In diabetic painful neuropathy, AmiKet showed a strong trend towards pain reduction. In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics. AmiKet is absorbed minimally following topical administration. Over 700 patients have now received topical AmiKet in clinical regimens, and it is well-tolerated with the adverse effects mainly being application site reactions. Both agents are polymodal, and several mechanisms may contribute to the peripheral efficacy of AmiKet. Topical AmiKet has the potential to be a first-line treatment option for PHN, and to be useful in other NP conditions. Furthermore, AmiKet has the potential to be an adjunct to systemic therapies, with the targeting of a peripheral compartment in addition to central sites of action representing a rational drug combination.

'BioQuaRT' project: design of a novel in situ protocol for the simultaneous visualisation of chromosomal aberrations and micronuclei after irradiation at microbeam facilities

International Nuclear Information System (INIS)

Patrono, C.; Testa, A.; Monteiro Gil, O.; Giesen, U.; Langner, F.; Rabus, H.; Pinto, M.

2015-01-01

The aim of the 'BioQuaRT' (Biologically weighted Quantities in Radiotherapy) project is to develop measurement techniques for characterising charged particle track structure on different length scales, and to correlate at the cellular level the track structure properties with the biological effects of radiation. This multi-scale approach will allow characterisation of the radiation qualities used in radiotherapy and the related biological effects. Charged-particle microbeam facilities were chosen as the platforms for all radiobiology experiments in the 'BioQuaRT' project, because they allow targeting single cells (or compartments of a cell) with a predefined number of ionising particles and correlating the cell-by-cell induced damage with type and energy of the radiation and with the number of ions per cell. Within this project, a novel in situ protocol was developed for the analysis of the mis-repaired and/or unrepaired chromosome damage induced by charged-particle irradiations at the Physikalisch-Technische Bundesanstalt (PTB) ion microbeam facility. Among the cytogenetic biomarkers to detect and estimate radiation-induced DNA damage in radiobiology, chromosomal aberrations and micronuclei were chosen. The characteristics of the PTB irradiation system required the design of a special in situ assay: specific irradiation dishes with a base made from a bio-foil 25-μm thick and only 3000-4000 cells seeded and irradiated per dish. This method was developed on Chinese hamster ovary (CHO) cells, one of the most commonly used cell lines in radiobiology in vitro experiments. The present protocol allows the simultaneous scoring of chromosome aberrations and micronuclei on the same irradiated dish. Thanks to its versatility, this method could also be extended to other radiobiological applications besides the single-ion microbeam irradiations. (authors)

From "Special K" to "Special M": the evolution of the recreational use of ketamine and methoxetamine.

Science.gov (United States)

Corazza, Ornella; Assi, Sulaf; Schifano, Fabrizio

2013-06-01

This article reviews the recreational use of ketamine ("Special K"; KET) and explores the recent diffusion of its new derivative methoxetamine ("Special M"; MXE). The literature search on the nonclinical/recreational use of KET and MXE was carried out in a range of medical databases. Considering the limitations of peer-reviewed information, data were integrated with a qualitative assessment of a range of websites, drug fora, and other online resources including e-newsgroups, chat rooms, mailing lists, e-newsletters, and bulletin boards. The recreational use of KET has started since its discovery in 1962. This was due to its rapid onset, short duration of action, and peculiar psychotropic effects ("K-hole"). The latter effect ranges from confusion to dissociation and depersonalization (near-death experience). However, KET abuse is often associated with physical and psychological side effects, of which the worst is urological/bladder toxicity. Recently, MXE has emerged as a legal and "bladder-friendly" KET alternative. MXE presents with the same dissociative effect of KET, but with slower onset and longer duration of action. However, MXE seems to be associated with worse side effects than KET, ranging from mood disturbances/suicidal attempts to acute cerebellar toxicity. After 50 years of its discovery, KET has led to the emergence of MXE. However, this latter derivative does not appear to be a safer alternative to KET itself. © 2013 John Wiley & Sons Ltd.

Ketoconazole-induced testicular damage in rats reduced by Gentiana extract.

Science.gov (United States)

Amin, Amr

2008-04-01

Ketoconazole (KET) is an antifungal drug with a broad spectrum of activity that also induces reproductive toxicity in humans and animals. The protective effect of Gentiana (GEN) extract (Gentiana lutea) against KET-induced testicular damage was evaluated in male Wistar rats. GEN extract was administered orally (1g/kgbwt/day) for 26 days. Three weeks after extract administration, KET was co-administered intraperitoneally at a dose of 100mg/kg once a day for 5 days. KET-induced reproductive toxicity was associated with clear reductions of the weights of testes and epididymides, sperm indices and serum testosterone levels. KET also induced severe testicular histopathological lesions such as degeneration of the seminiferous tubules and depletion of germ cells. In addition, marked oxidative damage to testicular lipids and alterations of natural antioxidants (catalase (CAT) and superoxide dismutase (SOD)) were reported in association with KET toxicity. Most of the KET-induced effects were greatly decreased with the concomitant application of GEN extract. This study suggests a protective role of GEN extract that could be attributed to its antioxidant properties.

A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome

OpenAIRE

Moaddel, Ruin; Venkata, Swarajya Lakshmi Vattem; Tanga, Mary J.; Bupp, James E.; Green, Carol E.; Iyer, Lalitha; Furimsky, Anna; Goldberg, Michael E.; Torjman, Marc C.; Wainer, Irving W.

2010-01-01

A parallel chiral/achiral LC-MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in Complex Regional Pain Syndrome (CRPS) patients receiving a 5-day continuous infusion of a sub-anesthetic dose of (R,S)-Ket. The method was also validated for the determination of the enantiomers of the Ket metabolites norketamine, (R)-and (S)-norKet and dehydronorketamine, (R)- and (S)-DHNK, as well as the diastereomeric ...

Estudo eletromiográfico dos músculos adutor longo e vasto medial (fibras oblíquas), durante exercícios de agachamento com e sem a adução do quadril

OpenAIRE

Fabio de Faro Passos

2006-01-01

INTRODUÇÃO: os músculos adutor longo (ADL) e vasto medial (VM), incluindo suas fibras oblíquas (VMO), possuem relações anatômicas e funcionais. O músculo VMO é estabilizador da patela, portanto inúmeros trabalhos EMG procuram determinar exercícios que aumentem a atividade deste músculo. Este estudo teve como objetivo relacionar a atividade do músculo VMO com a adução do quadril e com a contração do músculo ADL em exercícios de agachamento com e sem apoio dorsal para ambos os sexos. CASUÍSTICA...

Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources.

Science.gov (United States)

Kaushal, Prem Singh; Talawar, Ramappa K; Krishna, P D V; Varshney, Umesh; Vijayan, M

2008-05-01

Uracil-DNA glycosylase (UNG), a repair enzyme involved in the excision of uracil from DNA, from mycobacteria differs from UNGs from other sources, particularly in the sequence in the catalytically important loops. The structure of the enzyme from Mycobacterium tuberculosis (MtUng) in complex with a proteinaceous inhibitor (Ugi) has been determined by X-ray analysis of a crystal containing seven crystallographically independent copies of the complex. This structure provides the first geometric characterization of a mycobacterial UNG. A comparison of the structure with those of other UNG proteins of known structure shows that a central core region of the molecule is relatively invariant in structure and sequence, while the N- and C-terminal tails exhibit high variability. The tails are probably important in folding and stability. The mycobacterial enzyme exhibits differences in UNG-Ugi interactions compared with those involving UNG from other sources. The MtUng-DNA complex modelled on the basis of the known structure of the complex involving the human enzyme indicates a domain closure in the enzyme when binding to DNA. The binding involves a larger burial of surface area than is observed in binding by human UNG. The DNA-binding site of MtUng is characterized by the presence of a higher proportion of arginyl residues than is found in the binding site of any other UNG of known structure. In addition to the electrostatic effects produced by the arginyl residues, the hydrogen bonds in which they are involved compensate for the loss of some interactions arising from changes in amino-acid residues, particularly in the catalytic loops. The results arising from the present investigation represent unique features of the structure and interaction of mycobacterial Ungs.

Kroppen som monitor

DEFF Research Database (Denmark)

Filges, Tine

2005-01-01

Tine Filges tager fat i de unges brug og forhold til porno, og har som en central pointe, at unge langt fra er en homogen gruppe. Der er væsentlige forskelle i unges forhold til deres krop. Dette lyder måske banalt og indlysende, men det er en pointe, der ofte glemmes i den offentlige debat om unge...... og deres kroppe. Abstract: Unges kroppe forbindes ofte med risici og farer. Vi lurer farer alle steder, og medierne er fulde af overskrifter: Fedmeepidemier. Unge med åreforkalkning. Druk. Porno. Spiseforstyrrelser. Selvskadende adfærd. I takt med at kroppen monitoreres, er den i stigende grad blevet...... koloniseret af en bekymret hær af forskere, forældre, pædagoger og terapeuter. Vi spørger ængsteligt: Vil de unge lave deres krop om livet igennem? Vil de virkelig have plastik i brysterne? Vil den næste generation tage Viagra som 18-årige? Kan unge indgå i intime relationer, når de er vokset op med porno på...

Stereoselective and regiospecific hydroxylation of ketamine and norketamine.

Science.gov (United States)

Desta, Zeruesenay; Moaddel, Ruin; Ogburn, Evan T; Xu, Cong; Ramamoorthy, Anuradha; Venkata, Swarajya Lakshmi Vattem; Sanghvi, Mitesh; Goldberg, Michael E; Torjman, Marc C; Wainer, Irving W

2012-11-01

The objective was to determine the cytochrome P450s (CYPs) responsible for the stereoselective and regiospecific hydroxylation of ketamine [(R,S)-Ket] to diastereomeric hydroxyketamines, (2S,6S;2R,6R)-HK (5a) and (2S,6R;2R,6S)-HK (5b) and norketamine [(R,S)-norKet] to hydroxynorketamines, (2S,6S;2R,6R)-HNK (4a), (2S,6R;2R,6S)-HNK (4b), (2S,5S;2R,5R)-HNK (4c), (2S,4S;2R,4R)-HNK (4d), (2S,4R;2R,4S)-HNK (4e), (2S,5R;2R,5S)-HNK (4f). The enantiomers of Ket and norKet were incubated with characterized human liver microsomes (HLMs) and expressed CYPs. Metabolites were identified and quantified using LC/MS/MS and apparent kinetic constants estimated using single-site Michaelis-Menten, Hill or substrate inhibition equation. 5a was predominantly formed from (S)-Ket by CYP2A6 and N-demethylated to 4a by CYP2B6. 5b was formed from (R)- and (S)-Ket by CYP3A4/3A5 and N-demethylated to 4b by multiple enzymes. norKet incubation produced 4a, 4c and 4f and minor amounts of 4d and 4e. CYP2A6 and CYP2B6 were the major enzymes responsible for the formation of 4a, 4d and 4f, and CYP3A4/3A5 for the formation of 4e. The 4b metabolite was not detected in the norKet incubates. 5a and 4b were detected in plasma samples from patients receiving (R,S)-Ket, indicating that 5a and 5b are significant Ket metabolites. Large variations in HNK concentrations were observed suggesting that pharmacogenetics and/or metabolic drug interactions may play a role in therapeutic response.

D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression.

Science.gov (United States)

Moaddel, Ruin; Luckenbaugh, David A; Xie, Ying; Villaseñor, Alma; Brutsche, Nancy E; Machado-Vieira, Rodrigo; Ramamoorthy, Anuradha; Lorenzo, Maria Paz; Garcia, Antonia; Bernier, Michel; Torjman, Marc C; Barbas, Coral; Zarate, Carlos A; Wainer, Irving W

2015-01-01

(R,S)-ketamine is a rapid and effective antidepressant drug that produces a response in two thirds of patients with treatment-resistant depression (TRD). The underlying biochemical differences between a (R,S)-ketamine responder (KET-R) and non-responder (KET-NR) have not been definitively identified but may involve serine metabolism. The aim of the study was to examine the relationship between baseline plasma concentrations of D-serine and its precursor L-serine and antidepressant response to (R,S)-ketamine in TRD patients. Plasma samples were obtained from 21 TRD patients at baseline, 60 min before initiation of the (R,S)-ketamine infusion. Patients were classified as KET-Rs (n = 8) or KET-NRs (n = 13) based upon the difference in Montgomery-Åsberg Depression Rating Scale (MADRS) scores at baseline and 230 min after infusion, with response defined as a ≥50 % decrease in MADRS score. The plasma concentrations of D-serine and L-serine were determined using liquid chromatography-mass spectrometry. Baseline D-serine plasma concentrations were significantly lower in KET-Rs (3.02 ± 0.21 μM) than in KET-NRs (4.68 ± 0.81 μM), p < 0.001. A significant relationship between baseline D-serine plasma concentrations and percent change in MADRS at 230 min was determined using a Pearson correlation, r = 0.77, p < 0.001, with baseline D-serine explaining 60 % of the variance in (R,S)-ketamine response. The baseline concentrations of L-serine (L-Ser) in KET-Rs were also significantly lower than those measured in KET-NRs (66.2 ± 9.6 μM vs 242.9 ± 5.6 μM, respectively; p < 0.0001). The results demonstrate that the baseline D-serine plasma concentrations were significantly lower in KET-Rs than in KET-NRs and suggest that this variable can be used to predict an antidepressant response following (R,S)-ketamine administration.

Investigating the within-herd prevalence and risk factors for ketosis in dairy cattle in Ontario as diagnosed by the test-day concentration of β-hydroxybutyrate in milk.

Science.gov (United States)

Tatone, Elise H; Duffield, Todd F; LeBlanc, Stephen J; DeVries, Trevor J; Gordon, Jessica L

2017-02-01

An observational study of 790 to over 3,000 herds was conducted to estimate the within-herd prevalence and cow-level risk factors for ketosis in dairy cattle in herds that participate in a Dairy Herd Improvement Association (DHIA) program. Ketosis or hyperketolactia (KET) was diagnosed as milk β-hydroxybutyrate ≥0.15 mmol/L at first DHIA test when tested within the first 30 d in milk. Seven hundred ninety-five herds providing at least 61 first milk tests from June 2014 to December 2015 were used to estimate the provincial within-herd prevalence of KET. All herds on DHIA in Ontario (n = 3,042) were used to construct cow-level multilevel logistic regression models to investigate the association of DHIA collected variables with the odds of KET at first DHIA milk test. Primiparous and multiparous animals were modeled independently. The cow-level KET prevalence in Ontario was 21%, with an average within-herd prevalence of 21% (standard deviation = 10.6) for dairy herds enrolled in a DHIA program. The prevalence of KET had a distinct seasonality with the lowest prevalence occurring from July to November. Automatic milking systems (AMS) were associated with increased within-herd prevalence, as well as increased odds of KET in multiparous animals at first test (odds ratio: 1.45; 95% confidence interval: 1.30 to 1.63). Jersey cattle had over 1.46 times higher odds of KET than Holstein cattle. Milk fat yield ≥1.12 kg/d at the last test of the previous lactation was associated with decreased odds of KET in the current lactation (odds ratio: 0.56; 95% confidence interval: 0.53 to 0.59). Increased days dry and longer calving intervals, for multiparous animals, and older age at first calving for primiparous animals increased the odds of KET at first test. This study confirms previous findings that increased days dry, longer calving intervals, and increased age at first calving are associated with increased odds of KET and is the first report of increased KET in herds with

Kollektivet som korrektiv

DEFF Research Database (Denmark)

Krøjer, Jo; Hutters, Camilla

2008-01-01

I Danmark har de unge individuel valgfrihed, når det kommer til valget af videregående uddannelse. Der er ikke nogen uddannelsespligt - valget er op til den unge. Den etablerede uddannelsesvejledning initierer et selvarbejde, hvorunder de unge anspores til at arbejde individuelt med at træffe det...... rette uddannelsesvalg. De unge oplever uddannelsesvalget som et ensomt og belastende arbejde. Så hvad sker der, når unge kollektivt reflekterer over at skulle vælge uddannelse? Artiklen præsenterer fortælleværksteder som metode til kollektive korrektioner af neoliberal regulering....

An unconventional family 1 uracil DNA glycosylase in Nitratifractor salsuginis.

Science.gov (United States)

Li, Jing; Chen, Ran; Yang, Ye; Zhang, Zhemin; Fang, Guang-Chen; Xie, Wei; Cao, Weiguo

2017-12-01

The uracil DNA glycosylase superfamily consists of at least six families with a diverse specificity toward DNA base damage. Family 1 uracil N-glycosylase (UNG) exhibits exclusive specificity on uracil-containing DNA. Here, we report a family 1 UNG homolog from Nitratifractor salsuginis with distinct biochemical features that differentiate it from conventional family 1 UNGs. Globally, the crystal structure of N. salsuginisUNG shows a few additional secondary structural elements. Biochemical and enzyme kinetic analysis, coupled with structural determination, molecular modeling, and molecular dynamics simulations, shows that N. salsuginisUNG contains a salt bridge network that plays an important role in DNA backbone interactions. Disruption of the amino acid residues involved in the salt bridges greatly impedes the enzymatic activity. A tyrosine residue in motif 1 (GQDPY) is one of the distinct sequence features setting family 1 UNG apart from other families. The crystal structure of Y81G mutant indicates that several subtle changes may account for its inactivity. Unlike the conventional family 1 UNG enzymes, N. salsuginisUNG is not inhibited by Ugi, a potent inhibitor specific for family 1 UNG. This study underscores the diversity of paths that a uracil DNA glycosylase may take to acquire its unique structural and biochemical properties during evolution. Structure data are available in the PDB under accession numbers 5X3G and 5X3H. © 2017 Federation of European Biochemical Societies.

Hvis en kartoffel er forkert, hvad er en Mars-bar så?

DEFF Research Database (Denmark)

Lichtenstein, Mia Beck; Thomsen, Freja; Hinze, Cecilie

2016-01-01

Danske unge er de slankeste af 41 europæiske unge, men de føler sig ofte tykke og går på slankekur. Hvad er årsagen, og hvorfor er det et problem?......Danske unge er de slankeste af 41 europæiske unge, men de føler sig ofte tykke og går på slankekur. Hvad er årsagen, og hvorfor er det et problem?...

Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences.

Science.gov (United States)

Sampaio, Luis Rafael Leite; Cysne Filho, Francisco Maurício Sales; de Almeida, Jamily Cunha; Diniz, Danilo Dos Santos; Patrocínio, Cláudio Felipe Vasconcelos; de Sousa, Caren Nádia Soares; Patrocínio, Manoel Cláudio Azevedo; Macêdo, Danielle; Vasconcelos, Silvânia Maria Mendes

2018-03-01

Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats. Male Wistar rats (200-300 g) were treated for 10 days with saline, CP or ALA alone or in combination with CP previous to KET and the behavioral (open field, Y-maze and PPI tests) and oxidative tests were performed on the last day of treatment. The results showed that KET induced hyperlocomotion, impaired working memory and decreased PPI. CP alone or in combination with ALA prevented KET-induced behavioral effects. In addition, the administration of KET decreased GSH and increased nitrite, lipid peroxidation and myeloperoxidase activity. CP alone or combined with ALA prevented the oxidative alterations induced by KET. In conclusion, the treatment with KET in rats induced behavioral impairments accompanied by hippocampal oxidative alterations, possibly related to NMDA receptors hypofunction. Besides that, CP alone or combined with ALA prevented these effects, showing a beneficial activity as antipsychotic agents. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice

International Nuclear Information System (INIS)

Dhote, Franck; Carpentier, Pierre; Barbier, Laure; Peinnequin, André; Baille, Valérie; Pernot, Fabien; Testylier, Guy; Beaup, Claire; Foquin, Annie

2012-01-01

Epileptic seizures and status epilepticus (SE) induced by the poisoning with organophosphorus nerve agents (OP), like soman, are accompanied by neuroinflammation whose role in seizure-related brain damage (SRBD) is not clear. Antagonists of the NMDA glutamate ionotropic receptors are currently among the few compounds able to arrest seizures and provide neuroprotection even during refractory status epilepticus (RSE). Racemic ketamine (KET), in combination with atropine sulfate (AS), was previously shown to counteract seizures and SRBD in soman-poisoned guinea-pigs. In a mouse model of severe soman-induced SE, we assessed the potentials of KET/AS combinations as a treatment for SE/RSE-induced SRBD and neuroinflammation. When starting 30 min after soman challenge, a protocol involving six injections of a sub-anesthetic dose of KET (25 mg/kg) was evaluated on body weight loss, brain damage, and neuroinflammation whereas during RSE, anesthetic protocols were considered (KET 100 mg/kg). After confirming that during RSE, KET injection was to be repeated despite some iatrogenic deaths, we used these proof-of-concept protocols to study the changes in mRNA and related protein contents of some inflammatory cytokines, chemokines and adhesion molecules in cortex and hippocampus 48 h post-challenge. In both cases, the KET/AS combinations showed important neuroprotective effects, suppressed neutrophil granulocyte infiltration and partially suppressed glial activation. KET/AS could also reduce the increase in mRNA and related pro-inflammatory proteins provoked by the poisoning. In conclusion, the present study confirms that KET/AS treatment has a strong potential for SE/RSE management following OP poisoning. The mechanisms involved in the reduction of central neuroinflammation remain to be studied. -- Highlights: ► During soman-induced status epilepticus, ketamine-atropine limit brain damage. ► Molecular neuroinflammatory response is strongly decreased. ► Glial activation is

Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice

Energy Technology Data Exchange (ETDEWEB)

Dhote, Franck [Département de Toxicologie et risques chimiques, Institut de Recherche Biomédicale des armées – Centre de recherches du Service de santé des armées IRBA-CRSSA, 24 avenue des Maquis du Grésivaudan, B.P. 87, 38702 La Tronche cedex (France); Carpentier, Pierre; Barbier, Laure [Département de Toxicologie et risques chimiques, Institut de Recherche Biomédicale des armées – Centre de recherches du Service de santé des armées IRBA-CRSSA, 24 avenue des Maquis du Grésivaudan, B.P. 87, 38702 La Tronche cedex (France); Peinnequin, André [Département Effets biologiques des rayonnements, Institut de Recherche Biomédicale des armées – Centre de recherches du Service de santé des armées IRBA-CRSSA, 24 avenue des Maquis du Grésivaudan, B.P. 87, 38702 La Tronche cedex (France); Baille, Valérie; Pernot, Fabien; Testylier, Guy; Beaup, Claire; Foquin, Annie [Département de Toxicologie et risques chimiques, Institut de Recherche Biomédicale des armées – Centre de recherches du Service de santé des armées IRBA-CRSSA, 24 avenue des Maquis du Grésivaudan, B.P. 87, 38702 La Tronche cedex (France); others, and

2012-03-01

Epileptic seizures and status epilepticus (SE) induced by the poisoning with organophosphorus nerve agents (OP), like soman, are accompanied by neuroinflammation whose role in seizure-related brain damage (SRBD) is not clear. Antagonists of the NMDA glutamate ionotropic receptors are currently among the few compounds able to arrest seizures and provide neuroprotection even during refractory status epilepticus (RSE). Racemic ketamine (KET), in combination with atropine sulfate (AS), was previously shown to counteract seizures and SRBD in soman-poisoned guinea-pigs. In a mouse model of severe soman-induced SE, we assessed the potentials of KET/AS combinations as a treatment for SE/RSE-induced SRBD and neuroinflammation. When starting 30 min after soman challenge, a protocol involving six injections of a sub-anesthetic dose of KET (25 mg/kg) was evaluated on body weight loss, brain damage, and neuroinflammation whereas during RSE, anesthetic protocols were considered (KET 100 mg/kg). After confirming that during RSE, KET injection was to be repeated despite some iatrogenic deaths, we used these proof-of-concept protocols to study the changes in mRNA and related protein contents of some inflammatory cytokines, chemokines and adhesion molecules in cortex and hippocampus 48 h post-challenge. In both cases, the KET/AS combinations showed important neuroprotective effects, suppressed neutrophil granulocyte infiltration and partially suppressed glial activation. KET/AS could also reduce the increase in mRNA and related pro-inflammatory proteins provoked by the poisoning. In conclusion, the present study confirms that KET/AS treatment has a strong potential for SE/RSE management following OP poisoning. The mechanisms involved in the reduction of central neuroinflammation remain to be studied. -- Highlights: ► During soman-induced status epilepticus, ketamine-atropine limit brain damage. ► Molecular neuroinflammatory response is strongly decreased. ► Glial activation is

The Interaction among Microbiota, Immunity, and Genetic and Dietary Factors Is the Condicio Sine Qua Non Celiac Disease Can Develop

Directory of Open Access Journals (Sweden)

D. Pagliari

2015-01-01

Full Text Available Celiac disease (CD is an immune-mediated enteropathy, triggered by dietary wheat gluten and similar proteins of barley and rye in genetically susceptible individuals. This is a complex disorder involving both environmental and immune-genetic factors. The major genetic risk factor for CD is determined by HLA-DQ genes. Dysfunction of the innate and adaptive immune systems can conceivably cause impairment of mucosal barrier function and development of localized or systemic inflammatory and autoimmune processes. Exposure to gluten is the main environmental trigger responsible for the signs and symptoms of the disease, but exposure to gluten does not fully explain the manifestation of CD. Thus, both genetic determination and environmental exposure to gluten are necessary for the full manifestation of CD; neither of them is sufficient alone. Epidemiological and clinical data suggest that other environmental factors, including infections, alterations in the intestinal microbiota composition, and early feeding practices, might also play a role in disease development. Thus, this interaction is the condicio sine qua non celiac disease can develop. The breakdown of the interaction among microbiota, innate immunity, and genetic and dietary factors leads to disruption of homeostasis and inflammation; and tissue damage occurs. Focusing attention on this interaction and its breakdown may allow a better understanding of the CD pathogenesis and lead to novel translational avenues for preventing and treating this widespread disease.

Den der ser, er den, der ses

DEFF Research Database (Denmark)

Bjerrum, Troels

2010-01-01

Udgangspunktet for afhandlingen er at undersøge, hvordan unge udsatte mennesker kan opnå personlig forandring ved hjælp af åndedrætstræning og meditation. Afhandlingen indleder med at beskrive de unges liv i en globalisering. Mange unge mennesker uden en social ansvarlig baggrund har ikke lært...... at foretage sig nødvendige samfundsmæssige valg. På grund af nederlag i hjem, skole, uddannelse og erhverv søger unge fællesskaber i ligestillede miljøer svarende til egen negative forventningspraksis. Den unge praktiserer en vanedannende negativ livsførelse, som eskalerer til yderligere socialt forfald. Unge......, der har levet i kriminalitet, misbrug og medmisbrug i lang tid, vil ikke være i stand til at realisere sig positivt pga. en personlig indgroet diskvalificerende forestilling. Afhandlingen forklarer, hvorledes negative oplevelser forbliver spændinger i menneskers krop. Teorier af Maurice Merleau...

Latitudinal and radial variation of >2 GeV/n protons and alpha-particles at solar maximum: ULYSSES COSPIN/KET and neutron monitor network observations

Directory of Open Access Journals (Sweden)

A. V. Belov

2003-06-01

Full Text Available Ulysses, launched in October 1990, began its second out-of-ecliptic orbit in September 1997. In 2000/2001 the spacecraft passed from the south to the north polar regions of the Sun in the inner heliosphere. In contrast to the first rapid pole to pole passage in 1994/1995 close to solar minimum, Ulysses experiences now solar maximum conditions. The Kiel Electron Telescope (KET measures also protons and alpha-particles in the energy range from 5 MeV/n to >2 GeV/n. To derive radial and latitudinal gradients for >2 GeV/n protons and alpha-particles, data from the Chicago instrument on board IMP-8 and the neutron monitor network have been used to determine the corresponding time profiles at Earth. We obtain a spatial distribution at solar maximum which differs greatly from the solar minimum distribution. A steady-state approximation, which was characterized by a small radial and significant latitudinal gradient at solar minimum, was interchanged with a highly variable one with a large radial and a small – consistent with zero – latitudinal gradient. A significant deviation from a spherically symmetric cosmic ray distribution following the reversal of the solar magnetic field in 2000/2001 has not been observed yet. A small deviation has only been observed at northern polar regions, showing an excess of particles instead of the expected depression. This indicates that the reconfiguration of the heliospheric magnetic field, caused by the reappearance of the northern polar coronal hole, starts dominating the modulation of galactic cosmic rays already at solar maximum.Key words. Interplanetary physics (cosmic rays; energetic particles – Space plasma physics (charged particle motion and acceleration

Når fremtiden tegner sig

DEFF Research Database (Denmark)

Nielsen, Mette Lykke; Katznelson, Noemi

Når fremtiden tegner sig er en rapport om unge i et yderkantsområder i Danmark. Den giver indblik i nogle af de subjektive, kulturelle og samfundsmæssige mekanismer der kan få betydning for, hvordan fremtiden tegner sig for unge.......Når fremtiden tegner sig er en rapport om unge i et yderkantsområder i Danmark. Den giver indblik i nogle af de subjektive, kulturelle og samfundsmæssige mekanismer der kan få betydning for, hvordan fremtiden tegner sig for unge....

The monoaminergic pathways and inhibition of monoamine transporters interfere with the antidepressive-like behavior of ketamine

Directory of Open Access Journals (Sweden)

Glauce Socorro de Barros Viana

2018-06-01

Full Text Available Ketamine (KET, a NMDA receptor antagonist, has been studied for its rapid and efficacious antidepressant effect, even for the treatment-resistant depression. Although depression is a major cause of disability worldwide, the treatment can be feasible, affordable and cost-effective, decreasing the population health burden. We evaluated the antidepressive-like effects of KET and its actions on monoamine contents (DA and its metabolites, as well as 5-HT and on tyrosine hydroxylase (TH. In addition DAT and SERT (DA and 5-HT transporters, respectively were also assessed. Male Swiss mice were divided into Control and KET-treated groups. The animals were acutely treated with KET (2, 5 or 10 mg/kg, i.p. and subjected to the forced swimming test, for evaluation of the antidepressive-like behavior. Imipramine and fluoxetine were used as references. The results showed that KET decreased dose-dependently the immobility time and shortly after the test, the animals were euthanized for striatal dissections and monoamine determinations. In addition, the brain (striata, hippocampi and prefrontal cortices was immunohistochemically processed for TH, DAT and SERT. KET at its higher dose increased DA and its metabolites (DOPAC and HVA and mainly 5-HT contents, in mice striata, effects associated with increases in TH and decreases in DAT immunoreactivities. Furthermore, reductions in SERT immunoreactivities were observed in the striatum and hippocampus. The results indicate that KET antidepressive-like effect probably involves, among other factors, monoaminergic pathways, as suggested by the increased striatal TH immunoreactivity and reduced brain DA (DAT and 5-HT (SERT transporters. Keywords: Ketamine, Antidepressive effect, Dopaminergic neurotransmission, Serotonergic neurotransmission, Monoamine transporters

Så rejser jeg mig op og vandrer tilbage til Paamiut

DEFF Research Database (Denmark)

Berliner, Peter

2012-01-01

I denne artikel undersøges indhold i og betydningen af unges teater monologer – som de fandt sted i forbindelse med C:ntact’s teater-opsætning med en gruppe unge i Paamiut. Forestillingen bestod af 8 monologer, der blev fremsat af de unge. Da der var tale om monologer undersøges det, hvad der er ...

Generation fucked up er en myte

DEFF Research Database (Denmark)

Kofod, Anne; Nielsen, Jens Christian

2005-01-01

Undersøgelsen ‘Det normale ungdomsliv - hverdagsliv, fællesskab, trivsel og fremtid' punkterer en række myter om, hvordan 12-18-årige danske unge lever deres hverdagsliv og oplever det at være ung i 2005. De unge viser sig at være både socialt bevidste og kompetente....

Average spectral power changes at the hippocampal electroencephalogram in schizophrenia model induced by ketamine.

Science.gov (United States)

Sampaio, Luis Rafael L; Borges, Lucas T N; Silva, Joyse M F; de Andrade, Francisca Roselin O; Barbosa, Talita M; Oliveira, Tatiana Q; Macedo, Danielle; Lima, Ricardo F; Dantas, Leonardo P; Patrocinio, Manoel Cláudio A; do Vale, Otoni C; Vasconcelos, Silvânia M M

2018-02-01

The use of ketamine (Ket) as a pharmacological model of schizophrenia is an important tool for understanding the main mechanisms of glutamatergic regulated neural oscillations. Thus, the aim of the current study was to evaluate Ket-induced changes in the average spectral power using the hippocampal quantitative electroencephalography (QEEG). To this end, male Wistar rats were submitted to a stereotactic surgery for the implantation of an electrode in the right hippocampus. After three days, the animals were divided into four groups that were treated for 10 consecutive days with Ket (10, 50, or 100 mg/kg). Brainwaves were captured on the 1st or 10th day, respectively, to acute or repeated treatments. The administration of Ket (10, 50, or 100 mg/kg), compared with controls, induced changes in the hippocampal average spectral power of delta, theta, alpha, gamma low or high waves, after acute or repeated treatments. Therefore, based on the alterations in the average spectral power of hippocampal waves induced by Ket, our findings might provide a basis for the use of hippocampal QEEG in animal models of schizophrenia. © 2017 Société Française de Pharmacologie et de Thérapeutique.

Motivation i erhvervsuddannelserne

DEFF Research Database (Denmark)

Katznelson, Noemi; Brown, Rikke

Denne rapport handler om de mange unge, der befolker erhvervsuddannelserne i Danmark. Den sætter fokus på, hvad der motiverer disse unge til at være på uddannelserne og på den hverdag, de har på skolerne. Rapporten giver et indblik i, hvordan de unge oplever mødet med faget, pædagogikken og lærer...

Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.

Science.gov (United States)

Bj Rås, Karine Ø; Sousa, Mirta M L; Sharma, Animesh; Fonseca, Davi M; S Gaard, Caroline K; Bj Rås, Magnar; Otterlei, Marit

2017-08-21

Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions and is known to be associated with DNA replication, but how BER is organized during replication is unclear. Here we coupled the iPOND (isolation of proteins on nascent DNA) technique with targeted mass-spectrometry analysis, which enabled us to detect all proteins required for BER on nascent DNA and to monitor their spatiotemporal orchestration at replication forks. We demonstrate that XRCC1 and other BER/single-strand break repair (SSBR) proteins are enriched in replisomes in unstressed cells, supporting a cellular capacity of post-replicative BER/SSBR. Importantly, we identify for the first time the DNA glycosylases MYH, UNG2, MPG, NTH1, NEIL1, 2 and 3 on nascent DNA. Our findings suggest that a broad spectrum of DNA base lesions are recognized and repaired by BER in a post-replicative process. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Percezione della città di Palermo: quartieri, giovani, identità, lingua e dialetto

DEFF Research Database (Denmark)

Christoffersen, Andreas W

2005-01-01

Italiensk, Palermo, Sicilien, perceptual dialectology, sociolingvistik, dialekt, sprogholdning, sprog, identitet, unge......Italiensk, Palermo, Sicilien, perceptual dialectology, sociolingvistik, dialekt, sprogholdning, sprog, identitet, unge...

Gendered features of learning and identity development

DEFF Research Database (Denmark)

Du, Xiangyun

2005-01-01

Hvad afholder unge kvinder fra at udanne sig til ingeniør? Xiang-Yun Du peger i sit ph.d.-studium på flere barrierer. Der er den traditionelle opfattelse, at en ingeniør er en mand. Unge piger har også et uklart billede af ingeniørfaget og kender ikke dets relevans, og unge piger vælger i øvrigt ...

Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA.

Directory of Open Access Journals (Sweden)

Kouichi Kitamura

Full Text Available The covalently closed circular DNA (cccDNA of the hepatitis B virus (HBV plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC DNA (partially double-stranded DNA into cccDNA in the nucleus. Recently, antiviral cytidine deaminases, AID/APOBEC proteins, were shown to generate uracil residues in the NC-DNA through deamination, resulting in cytidine-to-uracil (C-to-U hypermutation of the viral genome. We investigated whether uracil residues in hepadnavirus DNA were excised by uracil-DNA glycosylase (UNG, a host factor for base excision repair (BER. When UNG activity was inhibited by the expression of the UNG inhibitory protein (UGI, hypermutation of NC-DNA induced by either APOBEC3G or interferon treatment was enhanced in a human hepatocyte cell line. To assess the effect of UNG on the cccDNA viral intermediate, we used the duck HBV (DHBV replication model. Sequence analyses of DHBV DNAs showed that cccDNA accumulated G-to-A or C-to-T mutations in APOBEC3G-expressing cells, and this was extensively enhanced by UNG inhibition. The cccDNA hypermutation generated many premature stop codons in the P gene. UNG inhibition also enhanced the APOBEC3G-mediated suppression of viral replication, including reduction of NC-DNA, pre-C mRNA, and secreted viral particle-associated DNA in prolonged culture. Enhancement of APOBEC3G-mediated suppression by UNG inhibition was not observed when the catalytic site of APOBEC3G was mutated. Transfection experiments of recloned cccDNAs revealed that the combination of UNG inhibition and APOBEC3G expression reduced the replication ability of cccDNA. Taken together, these data indicate that UNG excises uracil residues from the viral genome during or after cccDNA formation in the nucleus and imply that BER pathway activities decrease the antiviral effect of APOBEC3-mediated hypermutation.

Børn på YouTube – nydelse og nørderi

DEFF Research Database (Denmark)

Johansen, Stine Liv

2017-01-01

Mange børn og unge bruger dagligt adskillige timer på videodelingsplatformen YouTube. Her kan de dyrke deres individuelle interesser, deres ’guilty pleasures’ og følge med i youtuberes dagligliv. For mange børn og unge er muligheden for selv at producere indhold ligeledes en relevant del af...... attraktionen ved YouTube. På baggrund af en igangværende, kvalitativ undersøgelse præsenteres i denne artikel en række relevante perspektiver ved børn og unges brug af YouTube. Et væsentligt aspekt er, at voksne sjældent involverer sig i børn og unges brug af YouTube. Men hvis man ønsker at tage aktivt del...... børn og unges (digitale) dannelsesprocesser kan det godt betale sig at holde øje med, hvad de laver på YouTube – og forsøge at forstå, hvad de får ud af det....

Fixpunkter i Sisimiutstrong />

DEFF Research Database (Denmark)

Medonos, Jakub Christensen

2007-01-01

Ungdomsklubben i den grønlandske by Sisimiut er et fixpunkt for de unge. Her mødes de på egne præmisser og udfolder sig kreativt. Men der er andet og mere på spil. Det er nemlig gennem fixpunkter som ungdomsklubben, at de unge skaber en bevidsthed om Sisimiut som et særligt byrum.......Ungdomsklubben i den grønlandske by Sisimiut er et fixpunkt for de unge. Her mødes de på egne præmisser og udfolder sig kreativt. Men der er andet og mere på spil. Det er nemlig gennem fixpunkter som ungdomsklubben, at de unge skaber en bevidsthed om Sisimiut som et særligt byrum....

Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA.

Science.gov (United States)

Pedersen, Hege Lynum; Johnson, Kenneth A; McVey, Colin E; Leiros, Ingar; Moe, Elin

2015-10-01

Uracil-DNA N-glycosylase (UNG) is a DNA-repair enzyme in the base-excision repair (BER) pathway which removes uracil from DNA. Here, the crystal structure of UNG from the extremophilic bacterium Deinococcus radiodurans (DrUNG) in complex with DNA is reported at a resolution of 1.35 Å. Prior to the crystallization experiments, the affinity between DrUNG and different DNA oligonucleotides was tested by electrophoretic mobility shift assays (EMSAs). As a result of this analysis, two 16 nt double-stranded DNAs were chosen for the co-crystallization experiments, one of which (16 nt AU) resulted in well diffracting crystals. The DNA in the co-crystal structure contained an abasic site (substrate product) flipped into the active site of the enzyme, with no uracil in the active-site pocket. Despite the high resolution, it was not possible to fit all of the terminal nucleotides of the DNA complex into electron density owing to disorder caused by a lack of stabilizing interactions. However, the DNA which was in contact with the enzyme, close to the active site, was well ordered and allowed detailed analysis of the enzyme-DNA interaction. The complex revealed that the interaction between DrUNG and DNA is similar to that in the previously determined crystal structure of human UNG (hUNG) in complex with DNA [Slupphaug et al. (1996). Nature (London), 384, 87-92]. Substitutions in a (here defined) variable part of the leucine loop result in a shorter loop (eight residues instead of nine) in DrUNG compared with hUNG; regardless of this, it seems to fulfil its role and generate a stabilizing force with the minor groove upon flipping out of the damaged base into the active site. The structure also provides a rationale for the previously observed high catalytic efficiency of DrUNG caused by high substrate affinity by demonstrating an increased number of long-range electrostatic interactions between the enzyme and the DNA. Interestingly, specific interactions between residues

Desenvolvimento de uma ferramenta didática para o estudo da flexão composta oblíqua em seções quaisquer de concreto armado

Directory of Open Access Journals (Sweden)

P. H. C. De Lyra

Full Text Available Tendo em vista a experiência de professores e pesquisadores do Brasil e do exterior no contexto da busca de novos e melhores métodos didáticos para ensino de Engenharia, constata-se que o uso de recursos multimídia interativa constitui uma abordagem promissora, com amplas possibilidades de aplicação em disciplinas de graduação. Nesse contexto, o presente trabalho trata do desenvolvimento de uma ferramenta multimídia de apoio ao ensino da flexão composta oblíqua no concreto armado, apresentando as suas funcionalidades, a estrutura do código e exemplos de aplicação. Para a construção da ferramenta, o applet “Verificação de seções quaisquer de concreto armado sob flexão composta oblíqua”, foi utilizada a linguagem de programação JavaTM e o ambiente de desenvolvimento NetBeans 5.5.1. O applet tratado neste artigo está disponível na Internet no endereço http://www.lmc.ep.usp.br/pesquisas/TecEdu/.

Primary Care Use before Cancer Diagnosis in Adolescents and Young Adults - A Nationwide Register Study

DEFF Research Database (Denmark)

Ahrensberg, Jette Møller; Fenger-Grøn, Morten; Vedsted, Peter

2016-01-01

Unge med kræft går hyppigere til lægen end deres raske jævnaldrende i tiden før en kræftdiagnose. Et nyt studie viser, at unge med kræft oftere end kontrolgruppen søger deres praktiserende læge allerede 8 måneder før diagnosetidspunktet. Forskerne fandt, at unge med modermærkekræft oftere søgte d...

»Rücksichtslose Kritik alles Bestehenden«

DEFF Research Database (Denmark)

Ziegler, Magnus Møller

2018-01-01

Fra venstrehegelianisme til politisk økonomi: Allerede den unge Karl Marx udviklede et kritisk forskningsprogram.......Fra venstrehegelianisme til politisk økonomi: Allerede den unge Karl Marx udviklede et kritisk forskningsprogram....

Evaluering af tre projekter i Socialstyrelsens Forældreprogram

DEFF Research Database (Denmark)

Scavenius Sonne-Schmidt, Christoffer; Andersen, Luna Kragh; Frøslev-Thomsen, Kathrine

2018-01-01

I Danmark oplever vi i disse år en stigning i antallet af børn og unge med ADHD diagnoser og ADHD-lignende vanskeligheder, hvilket har medført øget fokus på effektive indsatser til de berør-te familier, børn og unge. Dette notat har til formål at beskrive implementering af tre sådanne indsatser......, herunder unge med ADHD (PMTO) samt Mentor- og støttekontaktpersons-ordningen (M-SKP) rettet mod unge. KiK og PMTO er begge manualbaserede og velafprøvede indsatser, mens M-SKP bygger på det eksisterende mentor- og støttekontaktpersonsarbejde, der foretages i danske kommuner, men i sig selv er en ny indsats...

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

DEFF Research Database (Denmark)

Akbari, M; Otterlei, M; Pena Diaz, Javier

2007-01-01

, indicating regulatory effects of oxidative stress on mitochondrial BER. To examine the overall organization of uracil-BER in nuclei and mitochondria, we constructed cell lines expressing EYFP (enhanced yellow fluorescent protein) fused to UNG1 or UNG2. These were used to investigate the possible presence...... BER processes are differently organized. Furthermore, the upregulation of mRNA for mitochondrial UNG1 after oxidative stress indicates that it may have an important role in repair of oxidized pyrimidines....

Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene

Directory of Open Access Journals (Sweden)

Ming Xu

2015-08-01

Full Text Available Background/Aims: Recent studies have indicated that CD38 gene deficiency results in dedifferentiation or transdifferentiation of arterial smooth muscle cells upon atherogenic stimulations. However, the molecular mechanisms mediating this vascular smooth muscle (SMC phenotypic switching remain unknown. Methods & Results: In the present study, we first characterized the phenotypic change in the primary cultures of coronary arterial myocytes (CAMs from CD38-/- mice. It was shown that CD38 deficiency decreased the expression of contractile marker calponin, SM22α and α-SMA but increased the expression of SMC dedifferentiation marker, vimentin, which was accompanied by enhanced cell proliferation. This phenotypic change in CD38-/- CAMs was enhanced by 7-ketocholesterol (7-Ket, an atherogenic stimulus. We further found that the CD38 deficiency decreased the expression and activity of nuclear factor E2-related factor 2 (Nrf2, a basic leucine zipper (bZIP transcription factor sensitive to redox regulation. Similar to CD38 deletion, Nrf2 gene silencing increased CAM dedifferentiation upon 7-Ket stimulation. In contrast, the overexpression of Nrf2 gene abolished 7-Ket-induced dedifferentiation in CD38-/- CAMs. Given the sensitivity of Nrf2 to oxidative stress, we determined the role of redox signaling in the regulation of Nrf2 expression and activity associated with CD38 effect in CAM phenotype changes. It was demonstrated that in CD38-/- CAMs, 7-Ket failed to stimulate the production of O2-., while in CD38+/+ CAMs 7-Ket induced marked O2-. production and enhancement of Nrf2 activity, which was substantially attenuated by NOX4 gene silencing. Finally, we demonstrated that 7-Ket-induced and NOX4-dependent O2-. production was inhibited by 8-Br-cADPR, an antagonist of cADPR or NED-19, an antagonist of NAADP as product of CD38 ADP-ribosylcyclase, which significantly inhibited the level of cytosolic Ca2+ and the activation of Nrf2 under 7-Ket. Conclusion

Diseño y validación de un método espectrofotométrico para el estudio de estabilidad de Benzocaína en un nuevo ungüento rectal

Directory of Open Access Journals (Sweden)

Yania Suárez Pérez

2001-12-01

Full Text Available Se desarrolló un método por espectrofotometría UV, que incluyó la extracción previa del producto de degradación de la benzocaína presente en un nuevo ungüento rectal, destinado al tratamiento del brote hemorroidal agudo. El método analítico se validó para el estudio de estabilidad química de este principio activo. Según los criterios estadísticos vigentes, el método resultó lineal, exacto, preciso, sensible y específico para el objetivo con el cual fue diseñado.A method including the previous extraction of the degradation product of benzocaine pesent in a new rectal ointment to treat acute haemorrhoid was developed by ultraviolet spectrophotometry. The analytical method was validated for the study of the chemical stability of this active principle. According to the standing statistical criteria, the method proved to be lineal, exact, accurate, sensitive and specific for the objective it was designed.

Living with Computers. Young Danes' Uses of and Thoughts on the Uses of Computers

DEFF Research Database (Denmark)

Stald, Gitte Bang

1998-01-01

Young Danes, computers,users, super users, non users, computer access, unge danskere, computere,brugere,superbrugere,ikke-brugere......Young Danes, computers,users, super users, non users, computer access, unge danskere, computere,brugere,superbrugere,ikke-brugere...

New model of universal gas-filled neutron tube

International Nuclear Information System (INIS)

Bespalov, D.F.; Bessarabskii, I.G.; Voitsik, L.R.; Mints, A.Z.

1985-01-01

The UNG-1 gas-filled neutron tube is serially produced. In type UNG neutron generators, the tube operates in the pulsed mode in the high voltage doubling circuit arrangement. During extended operation, its advantages were discovered: long operating time, fairly stable neutron yield, and simplicity of use and operation. However, the mean neutron yield (approx.10 7 s -1 ) generated by the tube in the optimal mode at the present time proved to be inadequate in solving numerous geophysical problems. So a model of a neutron tube, model UNG-2, was designed, ensuring an enhanced neutron yield of 10 8 s -1 in the continuous-operating mode. When the tube is connected to the high voltage doubling circuit, the mean neutron yield is only somewhat in excess of the neutron yield from the UNG-1 tube

Frihed, Lighed og Fællesskab i teenagefamilien

DEFF Research Database (Denmark)

Dahl, Karen Margrethe

Hovedformålet med afhandlingen har været at kategorisere forælder-ung-relationer på baggrund af deres relationer, hverdagsrutiner og regler. Afhandlingen undersøger den socioøkonomiske baggrund for disse familiepraksisser og sammenhænge mellem familiens socioøkonomiske ressourcer og hverdagspraks...... hverdagspraksisser på den ene side og unges risikoadfærd, livstilfredshed og oplevelse af personlig autonomi på den anden. Afhandlingens resultater er baseret på to store kvantitative datasæt, der bruger danske unge og deres mødre som respondenter....

Identification of fields with innovation potentials in vocational vducation and training (VET) in six Central European member countries of the European Union

DEFF Research Database (Denmark)

Knudsen, Hans Jørgen; Nielsen, Søren

2016-01-01

En undersøgelse af innovationspotentialet i seks centraleuropæiske lande (Bulgarien, Polen, Rumænien, Slovakiet, Tjekkiet, Ungarn. Fokus skulle være på hvad der kunne støtte unge elever på erhvervsskolerne (unge under 25)...

A.R.T. – Aggression Replacement Training

DEFF Research Database (Denmark)

Harbo, Lotte Junker; Domben, Eskil

2015-01-01

Artiklen indeholder en kort introduktion, eksemplificeret ved case, af det manualbaserede program til behandling af udadreagerende unge Aggression Replacement Training.......Artiklen indeholder en kort introduktion, eksemplificeret ved case, af det manualbaserede program til behandling af udadreagerende unge Aggression Replacement Training....

A clade in the QUASIMODO2 family evolved with vascular plants and supports a role for cell wall composition in adaptation to environmental changes.

Science.gov (United States)

Fuentes, Sara; Pires, Nuno; Østergaard, Lars

2010-08-01

The evolution of plant vascular tissue is tightly linked to the evolution of specialised cell walls. Mutations in the QUASIMODO2 (QUA2) gene from Arabidopsis thaliana were previously shown to result in cell adhesion defects due to reduced levels of the cell wall component homogalacturonic acid. In this study, we provide additional information about the role of QUA2 and its closest paralogues, QUASIMODO2 LIKE1 (QUL1) and QUL2. Within the extensive QUA2 family, our phylogenetic analysis shows that these three genes form a clade that evolved with vascular plants. Consistent with a possible role of this clade in vasculature development, QUA2 is highly expressed in the vascular tissue of embryos and inflorescence stems and overexpression of QUA2 resulted in temperature-sensitive xylem collapse. Moreover, in-depth characterisation of qua2 qul1 qul2 triple mutant and 35S::QUA2 overexpression plants revealed contrasting temperature-dependent stem development with dramatic effects on stem width. Taken together, our results suggest that the QUA2-specific clade contributed to the evolution of vasculature and illustrate the important role that modification of cell wall composition plays in the adaptation to changing environmental conditions, including changes in temperature.

Superconductivity at 2.8 K and 1.5 kbar in κ-(BEDT-TTF)2Cu2(CN)3: The first organic superconductor containing a polymeric copper cyanide anion

International Nuclear Information System (INIS)

Geiser, Urs; Wang Hau, H.; Carlson, K.D.; Williams, J.M.; Charlier, H.A. Jr.; Heindl, J.E.; Yaconi, G.A.; Love, B.J.; Lathrop, M.W.; Schirber, J.E.; Overmyer, D.L.; Ren, Jingquing; Whangbo, Myung-Hwan

1991-01-01

Attempts to synthesize new k-phase superconductors have concentrated on ET salts with complex anions composed of Cu(I) or Ag(I) metal ions and pseudohalide anions. The 'targeted anion approach', by use of a preformed anion found in KCu 2 (CN) 3 .H 2 O and the presence of trace amounts of water, led to the discovery of the first copper-cyanide containing superconductor, K-(ET) 2 Cu 2 (CN) 3 . The crystal structure, superconducting properties, and band electronic structure are described in this article. The complex k-(ET) 2 Cu 2 (CN) 3 is in many ways similar to the superconductor K-(ET) 2 Cu[N(CN) 2 ]Cl, the superconductor with the highest T c reported to date. 28 refs., 3 figs

75 FR 47662 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Science.gov (United States)

2010-08-06

..., RMBS, SBUX, SDS, SIRI, SKF, SLV, SMH, SNDK, SPY, T, TBT, TZA, UAUA, UNG, USO, UYG, V, VALE, VZ, WYNN, X..., SIRI, SKF, SLV, SMH, SNDK, SPY, T, TBT, TZA, UAUA, UNG, USO, UYG, V, VALE, VZ, WYNN, X, XHB, XLF, XRX...

Fra anbringelse til efterværn

DEFF Research Database (Denmark)

Dreyer Espersen, Laila

Når anbragte børn fylder 18 år, ophører deres anbringelse formelt set. Det betyder, at den unge som udgangspunkt skal klare sig selv. Men den nye efterværnsparagraf (§ 62a) i serviceloven giver mulighed for fortsat at støtte de unge, indtil de fylder 23 år. Det benytter man sig af på forskellig...... måde og i varierende omfang i danske kommuner. I denne rapport fremhæves gennem interview med 16 sagsbehandlere, en kommunalt ansat kontaktperson og en medarbejder ved en privat plejehjemsforening fra 10 kommuner nogle af de aspekter af efterværnsindsatsen, som kan være afgørende for, om den unge...... kommer godt ud af anbringelsen. Der er især fokuseret på de positive erfaringer, som sagsbehandlerne har haft i deres daglige arbejde med de unge i efterværnsforløb....

Measurements of $K^{0}_{s}$, \\PgL\\ + \\PagL, and $\\Xi^{+}+\\Xi^{-}$ production in pp, pPb, and PbPb collisions with CMS

CERN Document Server

Ni, Hong

2016-01-01

We present measurements of strange hadron ($K^{0}_{s}$, \\PgL\\ + \\PagL, and $\\Xi^{+} + \\Xi^{-}$) transverse momentum ($p^{}_{T}$) spectra in pp, pPb, and PbPb collisions over a wide range in charge-particle multiplicity and particle rapidity. The data were taken with the CMS detector at the LHC for pp collisions at $\\sqrt{s}$ = 7 TeV, pPb collisions at $\\sqrt{s_{NN}}$ = 5.02 TeV, and PbPb collisions at $\\sqrt{s_{NN}}$ = 2.76 TeV. We find the average transverse kinetic energy ($KE^{}_{T}$) increases with event multiplicity, with a faster rate for heavier particle species. At similar multiplicities, we observe the separation in the $\\left\\langle KE^{}_{T} \\right\\rangle$, which is defined as $\\left\\langle KE^{}_{T} \\right\\rangle = \\left\\langle m_{T}\\right\\rangle - m$, where $m_T = \\sqrt{m^{2} + p_{T}^{2}}$, between different particle species is larger for pp and pPb systems than PbPb system. In pPb collisions, $\\left\\langle KE^{}_{T} \\right\\rangle$ is found to be larger in the Pb-going direction than in the p-goi...

Poster Children of Integration and the Question of Being a “Good Danish Muslim”

DEFF Research Database (Denmark)

Pedersen, Sofie

2017-01-01

Denne artikel undersøger krydsfeltet mellem subjektivitetskonstruktion blandt unge muslimer og den danske velfærdsstats governmentalitet. Mere specifikt ser artiklen på kampagner, hvor unge studerende og erhvervsaktive med anden etnisk baggrund end dansk, primært muslimer, bruges strategisk som r...

Gymnasie ikke absolut fravalg af EUD

DEFF Research Database (Denmark)

Juul, Tilde Mette; Pless, Mette

2015-01-01

Den faldende søgning til erhvervsuddannelserne har i medierne og den politiske debat ofte været begrundet med, at de unge ikke ser erhvervsuddannelserne som prestigefyldte. Nyt forskningsprojekt fra Center for Ungdomsforskning viser, at de unges opfattelser af erhvervsuddannelserne er mere nuance...

Impact of Marcellus Shale natural gas development in southwest Pennsylvania on volatile organic compound emissions and regional air quality.

Science.gov (United States)

Swarthout, Robert F; Russo, Rachel S; Zhou, Yong; Miller, Brandon M; Mitchell, Brittney; Horsman, Emily; Lipsky, Eric; McCabe, David C; Baum, Ellen; Sive, Barkley C

2015-03-03

The Marcellus Shale is the largest natural gas deposit in the U.S. and rapid development of this resource has raised concerns about regional air pollution. A field campaign was conducted in the southwestern Pennsylvania region of the Marcellus Shale to investigate the impact of unconventional natural gas (UNG) production operations on regional air quality. Whole air samples were collected throughout an 8050 km(2) grid surrounding Pittsburgh and analyzed for methane, carbon dioxide, and C1-C10 volatile organic compounds (VOCs). Elevated mixing ratios of methane and C2-C8 alkanes were observed in areas with the highest density of UNG wells. Source apportionment was used to identify characteristic emission ratios for UNG sources, and results indicated that UNG emissions were responsible for the majority of mixing ratios of C2-C8 alkanes, but accounted for a small proportion of alkene and aromatic compounds. The VOC emissions from UNG operations accounted for 17 ± 19% of the regional kinetic hydroxyl radical reactivity of nonbiogenic VOCs suggesting that natural gas emissions may affect compliance with federal ozone standards. A first approximation of methane emissions from the study area of 10.0 ± 5.2 kg s(-1) provides a baseline for determining the efficacy of regulatory emission control efforts.

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

Directory of Open Access Journals (Sweden)

Reda RI

2017-03-01

Full Text Available Rana Ihab Reda,1 Ming Ming Wen,2 Amal Hassan El-Kamel1 1Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, 2Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt Purpose: The purpose of this study was to formulate ketoprofen (KET-loaded Eudragit L and Eudragit S nanofibers (NFs by the electrospinning technique for buccal administration to treat oral mucositis as a safe alternative to orally administered KET, which causes gastrointestinal tract (GIT side effects. Materials and methods: NFs were prepared by electrospinning using Eudragit L and Eudragit S. Several variables were evaluated to optimize NF formulation, such as polymer types and concentrations, applied voltage, flow rate and drug concentrations. Differential scanning calorimetry (DSC, Fourier transform infrared spectroscopy (FTIR and scanning electron microscopy (SEM and analyses of drug contents, hydration capacity, surface pH, drug release and ex vivo permeation were performed to evaluate the NFs. The selected formulation (F1 was evaluated in vivo on induced oral mucositis in rabbits. Results: SEM revealed that 20% polymer formed smooth and bead-free NFs. DSC results confirmed the amorphous nature of KET in the NFs. FTIR confirmed hydrogen bond formation between the drug and polymer, which stabilized the NFs. Both formulations (F1 and F2 had an acceptable surface pH. The drug loading was >90%. The amount of KET released from NF formulations was statistically significantly higher (P≤0.001 than that released from the corresponding solvent-casted films. The complete release of KET from F1 occurred within 2 hours. Ex vivo permeation study revealed that only a small fraction of drug permeated from F1, which was a better candidate than F2 for local buccal delivery. In vivo evaluation of F1 on oral mucositis induced in rabbits demonstrated that F1 reduced the clinical severity of mucositis in

Mobilitet, barrierer & muligheder

DEFF Research Database (Denmark)

Petersen, Mimi

2011-01-01

stereotypering. På den ene side peger udsagn fra de unge drenge på en oplevelse af at blive kriminaliseret i kraft af deres køn (det maskuline kombineret med at have en anden hudfarve). Og de unge piger oplever, at de udover at blive kategoriseret som ”indvandrere” også bliver kategoriseret som passive, umyndige...... som en vej ud af irakiske Kurdistan, men ikke tilbage til Danmark. Drengene fra familier med bedre økonomiske ressourcer giver udtryk for, ønske om at rejse til andre lande. På grund af begrænsede sproglige kompetencer oplever hovedparten af de unge (både i Danmark og i irakiske Kurdistan) barrierer i...... har planer for at flytte fra Kurdistan. De har dansk statsborgerskab, men de vil ikke tilbage til Danmark. I de fortællinger, som afhandlingen bygger på, er det tydeligt at samspillet mellem flere sociale dimensioner, spiller ind på de unges selvforståelse, tilhørsforhold, erfaringer og deres valg af...

Genetic parameters of blood β-hydroxybutyrate predicted from milk infrared spectra and clinical ketosis, and their associations with milk production traits in Norwegian Red cows.

Science.gov (United States)

Belay, T K; Svendsen, M; Kowalski, Z M; Ådnøy, T

2017-08-01

The aim of this study was to estimate genetic parameters for blood β-hydroxybutyrate (BHB) predicted from milk spectra and for clinical ketosis (KET), and to examine genetic association of blood BHB with KET and milk production traits (milk, fat, protein, and lactose yields, and milk fat, protein, and lactose contents). Data on milk traits, KET, and milk spectra were obtained from the Norwegian Dairy Herd Recording System with legal permission from TINE SA (Ås, Norway), the Norwegian Dairy Association that manages the central database. Data recorded up to 120 d after calving were considered. Blood BHB was predicted from milk spectra using a calibration model developed based on milk spectra and blood BHB measured in Polish dairy cows. The predicted blood BHB was grouped based on days in milk into 4 groups and each group was considered as a trait. The milk components for test-day milk samples were obtained by Fourier transform mid-infrared spectrometer with previously developed calibration equations from Foss (Hillerød, Denmark). Veterinarian-recorded KET data within 15 d before calving to 120 d after calving were used. Data were analyzed using univariate or bivariate linear animal models. Heritability estimates for predicted blood BHB at different stages of lactation were moderate, ranging from 0.250 to 0.365. Heritability estimate for KET from univariate analysis was 0.078, and the corresponding average estimate from bivariate analysis with BHB or milk production traits was 0.002. Genetic correlations between BHB traits were higher for adjacent lactation intervals and decreased as intervals were further apart. Predicted blood BHB at first test day was moderately genetically correlated with KET (0.469) and milk traits (ranged from -0.367 with protein content to 0.277 with milk yield), except for milk fat content from across lactation stages that had near zero genetic correlation with BHB (0.033). These genetic correlations indicate that a lower BHB is genetically

Vejledning - valg og læring

DEFF Research Database (Denmark)

Skovhus, Randi Boelskifte

2017-01-01

Afhandlingen undersøger, hvordan uddannelses-, erhvervs- og karrierevejledning i skolen udfolder sig i samspil med lærere og med det øvrige der foregår i skolen, og hvordan vejledningen giver mening for unge. Afhandlingens analyser giver indsigt i de unges deltagelse i vejledningen og diskuteres ...

Underkendelse, anerkendelse og udsatte positioner i folkeskolen

DEFF Research Database (Denmark)

Tireli, Üzeyir; Christensen, Kira Saabye; Dejgaard, Christoffer

2014-01-01

Kapitlet belyser hvordan skolelivet kan opleves og forstås af unge drenge med anden etnisk baggrund, som har haft det vanskeligt i folkeskolen. Kapitlet betoner vigtigheden af, at man interesserer sig for og kan indtage de unges perspektiver for at kunne skabe meningsfulde og inkluderende lærings...

DNA translocation by human uracil DNA glycosylase: the case of single-stranded DNA and clustered uracils.

Science.gov (United States)

Schonhoft, Joseph D; Stivers, James T

2013-04-16

Human uracil DNA glycosylase (hUNG) plays a central role in DNA repair and programmed mutagenesis of Ig genes, requiring it to act on sparsely or densely spaced uracil bases located in a variety of contexts, including U/A and U/G base pairs, and potentially uracils within single-stranded DNA (ssDNA). An interesting question is whether the facilitated search mode of hUNG, which includes both DNA sliding and hopping, changes in these different contexts. Here we find that hUNG uses an enhanced local search mode when it acts on uracils in ssDNA, and also, in a context where uracils are densely clustered in duplex DNA. In the context of ssDNA, hUNG performs an enhanced local search by sliding with a mean sliding length larger than that of double-stranded DNA (dsDNA). In the context of duplex DNA, insertion of high-affinity abasic product sites between two uracil lesions serves to significantly extend the apparent sliding length on dsDNA from 4 to 20 bp and, in some cases, leads to directionally biased 3' → 5' sliding. The presence of intervening abasic product sites mimics the situation where hUNG acts iteratively on densely spaced uracils. The findings suggest that intervening product sites serve to increase the amount of time the enzyme remains associated with DNA as compared to nonspecific DNA, which in turn increases the likelihood of sliding as opposed to falling off the DNA. These findings illustrate how the search mechanism of hUNG is not predetermined but, instead, depends on the context in which the uracils are located.

Madlavningslyst

DEFF Research Database (Denmark)

Andersen, Boris

2015-01-01

lever i veletablerede familiestrukturer, hvor fx spørgsmålet om motivation og forpligtelse bliver forhandlet i relation til de øvrige familiemedlemmer, eller – i den udstrækning der er tale om børn og unge - i en situation, hvor disse stadig bor hjemme og derfor indgår i en dagligdag præget...... - også - kan komme andre til gode. Hvilket formuleret med begreberne fra det praksisteoretiske perspektiv, hvormed de unges madlavning er blevet analyseret og fortolket: at de unges madlavningspraksis primært viser sig at blive koordineret af motivation med de dertil knyttede emotioner, hvorimod forhold...

Madlavningslyst

DEFF Research Database (Denmark)

Andersen, Boris

2016-01-01

lever i veletablerede familiestrukturer, hvor fx spørgsmålet om motivation og forpligtelse bliver forhandlet i relation til de øvrige familiemedlemmer, eller – i den udstrækning der er tale om børn og unge - i en situation, hvor disse stadig bor hjemme og derfor indgår i en dagligdag præget...... - også - kan komme andre til gode. Hvilket formuleret med begreberne fra det praksisteoretiske perspektiv, hvormed de unges madlavning er blevet analyseret og fortolket: at de unges madlavningspraksis primært viser sig at blive koordineret af motivation med de dertil knyttede emotioner, hvorimod forhold...

Situerede perspektiver på ungdom, uddannelsespolitik og frafald i erhvervsuddannelserne

DEFF Research Database (Denmark)

Jonasson, Charlotte; Klitmøller, Jacob; Grønborg, Lisbeth

2010-01-01

Uddannelse er en af de centrale aktiviteter, som samfundet forventer at unge mennesker tager del i. En stor del af unge uddannes på erhvervsskoler, som oplever højt frafald og lav prestige. Forskning i erhvervsuddannelserne generelt og frafaldet fra dem i særdeleshed har modtaget meget lidt forsk...

Det Frie Partnervalg

DEFF Research Database (Denmark)

Singla, Rashmi; Christiansen, Connie Carøe

2005-01-01

Etniske minoritetsunges forældre - især de muslimske - fremstilles i dag gennemgående som de unges modstandere i deres pardannelsesproces. Interview med unge dokumenterer i stedet et udbredt ønske om at have forældrene som medspillere i processen, hvormed de fraskriver sig den helt individualiser...

Yoga som terapeutisk aktivitet

DEFF Research Database (Denmark)

Broge, Julie Wolf

2014-01-01

Artiklen præsenterer yoga som terapeutisk aktivitet til børn og unge med særlige behov. Den gavnlige virkning af yoga uddybes.......Artiklen præsenterer yoga som terapeutisk aktivitet til børn og unge med særlige behov. Den gavnlige virkning af yoga uddybes....

Youth behind bars

DEFF Research Database (Denmark)

Bengtsson, Tea Torbenfeldt

2012-01-01

Gennem et etnografisk studie undersøger denne ph.d.-afhandling unges hverdagsliv og meningsskabelse på sikrede institutioner i Danmark. Afhandlingens formål er via teorier om ungdom og kriminalitet at undersøge, hvordan unge indespærret på sikrede institutioner skaber mening i deres hverdagsliv b...

Ketoprofen removal by O3 and O3/UV processes: Kinetics, transformation products and ecotoxicity

International Nuclear Information System (INIS)

Illés, Erzsébet; Szabó, Emese; Takács, Erzsébet; Wojnárovits, László; Dombi, András; Gajda-Schrantz, Krisztina

2014-01-01

Ozonation (O 3 ) and its combination with ultraviolet radiation (O 3 /UV) were used to decompose ketoprofen (KET). Depending on the initial KET concentration, fourteen to fifty time's faster KET degradation was achieved using combined O 3 /UV method compared to simple ozonation. Using both methods, formation of four major aromatic transformation products were observed: 3-(1-hydroxyethyl)benzophenone, 3-(1-hydroperoxyethyl) benzophenone, 1-(3-benzoylphenyl) ethanone and 3-ethylbenzophenone. In the combined treatment the degradation was mainly due to the direct effect of UV light, however, towards the end of the treatment, O 3 highly contributed to the mineralization of small carboxylic acids. High (∼ 90%) mineralization degree was achieved using the O 3 /UV method. Toxicity tests performed using representatives of three trophic levels of the aquatic ecosystems (producers, consumers and decomposers) Pseudokirchneriella subcapitata green algae, Daphnia magna zooplanktons and Vibrio fischeri bacteria showed that under the used experimental conditions the transformation products have significantly higher toxicity towards all the test organisms, than KET itself. The bacteria and the zooplanktons showed higher tolerance to the formed products than algae. The measured toxicity correlates well with the concentration of the aromatic transformation products, therefore longer treatments than needed for complete degradation of KET are strongly suggested, in order to avoid possible impact of aromatic transformation products on the aquatic ecosystem. - Highlights: • Ketoprofen degradation is significantly faster using O 3 /UV compared to ozonation. • The presence of O 3 enhances the overall mineralization. • Formation of four major aromatic by-products was observed. • The main step in the decomposition is the decarboxylation. • Degradation products have higher toxicity than ketoprofen itself

Design of triads for probing the direct through space energy transfers in closely spaced assemblies.

Science.gov (United States)

Camus, Jean-Michel; Aly, Shawkat M; Fortin, Daniel; Guilard, Roger; Harvey, Pierre D

2013-08-05

Using a selective stepwise Suzuki cross-coupling reaction, two trimers built on three different chromophores were prepared. These trimers exhibit a D(^)A1-A2 structure where the donor D (octa-β-alkyl zinc(II)porphyrin either as diethylhexamethyl, 10a, or tetraethyltetramethyl, 10b, derivatives) through space transfers the S1 energy to two different acceptors, di(4-ethylbenzene) zinc(II)porphyrin (A1; acceptor 1) placed cofacial with D, and the corresponding free base (A2; acceptor 2), which is meso-meso-linked with A1. This structure design allows for the possibility of comparing two series of assemblies, 9a,b (D(^)A1) with 10a,b (D(^)Â1-A2), for the evaluation of the S1 energy transfer for the global process D*→A2 in the trimers. From the comparison of the decays of the fluorescence of D, the rates for through space energy transfer, kET for 10a,b (kET ≈ 6.4 × 10(9) (10a), 5.9 × 10(9) s(-1) (10b)), and those for the corresponding cofacial D(^)A1 systems, 9a,b, (kET ≈ 5.0 × 10(9) (9a), 4.7 × 10(9) s(-1) (9b)), provide an estimate for kET for the direct through space D*→A2 process (i.e., kET(D(^)A1-A2) - kET(D(^)A1) = kET(D*→A2) ∼ 1 × 10(9) s(-1)). This channel of relaxation represents ∼15% of kET for D*→A1.

Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.

Science.gov (United States)

Xu, Ming; Zhang, Qiufang; Li, Pin-Lan; Nguyen, Thaison; Li, Xiang; Zhang, Yang

2016-01-01

Acid sphingomyelinase (ASM; gene symbol Smpd1) has been shown to play a crucial role in autophagy maturation by controlling lysosomal fusion with autophagosomes in coronary arterial smooth muscle cells (CASMCs). However, the underlying molecular mechanism by which ASM controls autophagolysosomal fusion remains unknown. In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release. In these CASMCs, ASM deficiency or TRPML1 gene silencing markedly inhibited 7-Ket-induced dynein activation. In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs. Finally, overexpression of TRPML1 proteins restored 7-Ket-induced lysosomal Ca(2+) release and autophagosome trafficking in Smpd1-/- CASMCs. Collectively, these results suggest that ASM plays a critical role in regulating lysosomal TRPML1-Ca(2+) signaling and subsequent dynein-mediated autophagosome trafficking, which leads its role in controlling autophagy maturation in CASMCs under atherogenic stimulation.

Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism.

Science.gov (United States)

Zimmermann, E; Wassmer, S; Steudle, V

1996-01-01

Calcium-alpha-ketoglutarate (Ca-ket) is known as a highly effective phosphate (P) binder in hemodialysis (HD) patients. In addition, alpha-ketoglutarate has been shown to improve metabolic alterations. We investigated the effect of long-term P-binding therapy with Ca-ket to determine whether P accumulation is the main reason of secondary hyperparathyroidism (HPT) in HD patients or not. Ca-ket was prescribed to 14 HD patients as a soluble preparation in a mean dosage of 4.5 g/day (0.975 g elemental Ca) for a period of 36 months. Serum P continuously dropped from prestudy 2.6 +/- 0.1 (mean +/- SEM) to 1.9 +/- 0.07 mmol/l (p < 0.001), whereas serum Ca increased from 2.2 +/- 0.1 to 2.47 +/- 0.08 mmol/l (p < 0.05). Thus, Ca/P ratio in serum converted significantly from 0.91 +/- 0.02 (prestudy) to 1.28 +/- 0.01 (p < 0.001). Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001). The present data show that long-term treatment with Ca-ket normalizes secondary HPT by simultaneously P binding and correcting Ca/P ratio in serum without vitamin D treatment.

Sexual behaviour among young Danes aged 15-29 years

DEFF Research Database (Denmark)

Jørgensen, Marianne Johansson; Maindal, Helle Terkildsen; Christensen, Kaj Sparle

2015-01-01

Langt de fleste klamydia-infektioner og provokerede aborter forekommer blandt unge i alderen 15-29 år. Mange af disse tilfælde kan formentlig relateres til seksuel risikoadfærd. Dette studie viser, at hovedparten af de unge anvender et kondom ved den seksuelle debut (kvinder: 70 %, mænd: 60 %), m...

Phénomènes neuro-inflammatoires au cours de l'état de mal épileptique induit par le soman. Correction par des combinaisons atropine-kétamine.

OpenAIRE

Dhote , Franck

2010-01-01

Epileptic seizures, status epilepticus (SE) and seizure-related brain damage (SRBD) due to organophosphorus nerve agent (OP) poisoning are accompanied by neuro-inflammatory events whose role in SRBD is not clear. Antagonists of the glutamatergic receptor NMDA, such as ketamine (KET), proved to be antiepileptic and neuroprotective even when SE is refractory to benzodiazepines 10 to 20 min after the initiation of seizures. Moreover, peripheral anti-inflammatory properties of KET have been descr...

Den ma(d)skuline smag

DEFF Research Database (Denmark)

Leer, Jonatan

2014-01-01

D. 14. april 1999 sendtes første afsnit af The Naked Chef med Jamie Oliver, der dengang var en ung, tynd knægt, som netop var flyttet til London. Programmet revolutionerede madprogramgenren, da det gjorde madlavning i hjemmet hipt og acceptabelt for unge, dynamiske mænd. Før Jamie Olivers indtog ...

Ungdom på erhvervsuddannelserne

DEFF Research Database (Denmark)

Vestergaard, Arnt Louw; Brown, Rikke; Katznelson, Noemi

Denne rapport handler om de mange unge, der befolker erhvervsuddannelserne i Danmark. Den zoomer ind på, hvordan de unge på erhvervsuddannelserne oplever det at vælge en erhvervsuddannelse, hvilke forventninger de har til uddannelsen når de starter, hvordan de oplever mødet med lærerne og det...

Stress i gymnasiet

DEFF Research Database (Denmark)

Nielsen, Anne Maj; Lagermann, Laila Colding

Denne undersøgelse af stress hos gymnasieelever i Aalborg viser, hvordan stress giver sig udslag i gymnasiet, hvad der stresser eleverne, hvad der adskiller de stressramte elever fra andre elever, hvordan et stressreduktionskurset Åben og Rolig for Unge virker for de unge i gymnasiet, og hvad der...... kan modvirke stress i gymnasiet....

Læringslyst og læringsvilje

DEFF Research Database (Denmark)

Murning, Susanne; Ebbensgaard, Aase Haubro Bitsch

2011-01-01

diskuterer, hvordan de nævnte forhold er tæt knyttet til elevernes medbragte sociokulturelle ballast. Unge fra miljøer uden uddannelsestradition må arbejde mere, have mere held og give afkald på flere ting, hvis de skal gennemføre en ungdomsuddannelse sammenlignet med unge fra miljøer med tradition...

Min danske drøm

DEFF Research Database (Denmark)

Weirsøe, Mathilde

2010-01-01

Unge indvandrerkvinder stormer ind på gymnasierne og derfra videre til universiteterne. De unge kvinder er ikke bare mønsterelever, men også mønsterbrydere. Hvorfor når de så langt? Er det i virkeligheden noget helt andet end forældrenes uddannelse, arbejde og indkomst, der har betydning for...

Inklusion, udsathed og tværprofessionelt samarbejde

DEFF Research Database (Denmark)

En antologi om tværprofessionelt arbejde. Mange professionelle inden for det pædagogiske område bliver i dag bedt om at arbejde tværprofessionelt i forbindelse med inklusion i skole og dagtilbud, i arbejdet med udsatte børn og unge og/eller i arbejdet med unge med uddannelsesudfordringer. Men hvad...

Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance.

Science.gov (United States)

Olano, Juanita; López, Beatriz; Reyes, Alejandro; Lemos, María del Pilar; Correa, Nidia; Del Portillo, Patricia; Barrera, Lucia; Robledo, Jaime; Ritacco, Viviana; Zambrano, María Mercedes

2007-11-01

The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.

Globalisering, skole og ungdom - i Syd

DEFF Research Database (Denmark)

Madsen, Ulla Ambrosius

2012-01-01

Med udgangspunkt i etnografiske studier af samspillet mellem skole og ungdom i overbygningsskoler i Hanoi, Lusaka og Recife, diskuterer artiklen spørgsmål om hvordan unge forhandler og positionerer sig i forhold til det moderne uddannelsesprojekt sådan som det manifesterer sig i forskellige socio......-kulturelle i Vietnam, Zambia og Brasilien. Artiklen introducerer kort til den generelle historiske baggrund for uddannelse i dette internationale perspektiv og diskuterer forestillingen om moderne progressiv pædagogik som dannelsesideal i en ikke-vestlig sammenhæng. Med reference til globaliseringsteorier til...... belysning af forholdet mellem unge og skole diskuteres forestillingen om transnationale ’uddannelseslandskaber’ som analyse-kategori til studiet af unges deltagelse i - moderne - skole og uddannelse....

Formidling af uheldsrisikoen ved spirituskørsel

DEFF Research Database (Denmark)

Kærup, Simon

2012-01-01

Selvom flere forskningsprojekter har påvist unges særlige risiko i Europa, når det kommer til alkohol, så har det vist sig svært at formidle denne risiko til unge bilister. I 2006 påbegyndtes et stort europæisk forskningsprojekt, DRUID (Driving under the Influence of Drugs, Alcohol and Medicines...

Fans skriver videre på deres foretrukne historier

DEFF Research Database (Denmark)

Petersen, Anne

2010-01-01

Fans skriver videre på deres foretrukne historier Vi har kendt til at lære gennem børn og unges optagethed af populærkultur gennem de sidste tredive år, men alligevel kan man have betænkeligheder ved at involvere unges egenkultur, idet det kan problemati- seres, hvilke erkendelsesformer, der er her....

Sexual behaviour in the general young population - factors associated with sexual risk behaviour

DEFF Research Database (Denmark)

Jørgensen, Marianne Johansson

2014-01-01

Trods mange forsøg på at forbedre unges seksuelle sundhed udgør seksuelt overførte infektioner og uønskede graviditeter stadig et betydeligt folkesundhedsproblem i den vestlige verden. Denne ph.d.-afhandling ser nærmere på, hvorfor mange unge danskere vælger at dyrke ubeskyttet sex, selvom det ka...

Problemskabende ungdomsgrupper i Danmark

DEFF Research Database (Denmark)

Perry, Kevin

2013-01-01

Baggrunden for denne rapport er et ønske om at belyse, hvad der kendetegner grupper af unge med problemskabende og kriminel adfærd – som grupper. Undersøgelsens empiri udgøres af interview 12 steder i landet med i alt 55 professionelle fagfolk, der kender og arbejder med de unge i lokalområderne....

Pure and Modified Co-Poly(amide-12-b-ethylene oxide) Membranes for Gas Separation Studied by Molecular Investigations.

Science.gov (United States)

De Lorenzo, Luana; Tocci, Elena; Gugliuzza, Annarosa; Drioli, Enrico

2012-06-28

This paper deals with a theoretical investigation of gas transport properties in a pure and modified PEBAX block copolymer membrane with N-ethyl-o/p-toluene sulfonamide (KET) as additive molecules. Molecular dynamics simulations using COMPASS force field, Gusev-Suter Transition State Theory (TST) and Monte Carlo methods were used. Bulk models of PEBAX and PEBAX/KET in different copolymer/additive compositions were assembled and analyzed to evaluate gas permeability and morphology to characterize structure-performance relationships.

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.

Science.gov (United States)

Girelli Zubani, Giulia; Zivojnovic, Marija; De Smet, Annie; Albagli-Curiel, Olivier; Huetz, François; Weill, Jean-Claude; Reynaud, Claude-Agnès; Storck, Sébastien

2017-04-03

During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respectively. Paradoxically, the MMR-nicking complex Pms2/Mlh1 is apparently dispensable for A-T mutagenesis. Thus, how detection of U:G mismatches is translated into the single-strand nick required for error-prone synthesis is an open question. One model proposed that UNG could cooperate with MMR by excising a second uracil in the vicinity of the U:G mismatch, but it failed to explain the low impact of UNG inactivation on A-T mutagenesis. In this study, we show that uracils generated in the G1 phase in B cells can generate equal proportions of A-T and G-C mutations, which suggests that UNG and MMR can operate within the same time frame during SHM. Furthermore, we show that Ung -/- Pms2 -/- mice display a 50% reduction in mutations at A-T base pairs and that most remaining mutations at A-T bases depend on two additional uracil glycosylases, thymine-DNA glycosylase and SMUG1. These results demonstrate that Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases. © 2017 Girelli Zubani et al.

Self-assembly behaviours of peptide-drug conjugates: influence of multiple factors on aggregate morphology and potential self-assembly mechanism

Science.gov (United States)

Fan, Qin; Ji, Yujie; Wang, Jingjing; Wu, Li; Li, Weidong; Chen, Rui; Chen, Zhipeng

2018-04-01

Peptide-drug conjugates (PDCs) as self-assembly prodrugs have the unique and specific features to build one-component nanomedicines. Supramolecular structure based on PDCs could form various morphologies ranging from nanotube, nanofibre, nanobelt to hydrogel. However, the assembly process of PDCs is too complex to predict or control. Herein, we investigated the effects of extrinsic factors on assembly morphology and the possible formation of nanostructures based on PDCs. To this end, we designed a PDC consisting of hydrophobic drug (S)-ketoprofen (Ket) and valine-glutamic acid dimeric repeats peptide (L-VEVE) to study their assembly behaviour. Our results showed that the critical assembly concentration of Ket-L-VEVE was 0.32 mM in water to form various nanostructures which experienced from micelle, nanorod, nanofibre to nanoribbon. The morphology was influenced by multiple factors including molecular design, assembly time, pH and hydrogen bond inhibitor. On the basis of experimental results, we speculated the possible assembly mechanism of Ket-L-VEVE. The π-π stacking interaction between Ket molecules could serve as an anchor, and hydrogen bonded-induced β-sheets and hydrophilic/hydrophobic balance between L-VEVE peptide play structure-directing role in forming filament-like or nanoribbon morphology. This work provides a new sight to rationally design and precisely control the nanostructure of PDCs based on aromatic fragment.

Oral Candida in Patients with Fixed Orthodontic Appliance: In Vitro Combination Therapy.

Science.gov (United States)

Alhamadi, Wisam; Al-Saigh, Rafal J; Al-Dabagh, Nebras N; Al-Humadi, Hussam W

2017-01-01

Fixed orthodontic appliance (FOA) increases the cariogenic microorganisms of mouth including candida. The aim was to evaluate the pharmacodynamic effects of some antibacterial drugs in combination with most applicable antifungal agents on candida isolated from patients with FOA. Three antifungal agents (amphotericin B (AMB), ketoconazole (KET), and itraconazole (ITZ)) and three antibacterial drugs (ciprofloxacin (CIP), doxycycline (DOX), and metronidazole (MET)) with serial concentrations have been used and microdilution broth method has been done for single and combination therapy, then fungal growth was assessed spectrophotometrically, and the combinations were evaluated by bliss independent analysis. According to bliss independent interaction, the synergistic interactions depended on Δ E values that showed the best for CIP was with AMB (Δ E = 55.14) followed with KET (Δ E = 41.23) and lastly ITR (Δ E = 39.67) at CIP = 150 mg/L. DOX was optimal with KET (Δ E = 42.11) followed with AMB (Δ E = 40.77) and the lowest with ITR (Δ E = 9.12) at DOX = 75 mg/L. MET is the best with AMB (Δ E = 40.95) and then with ITR (Δ E = 35.45) and finally KET (Δ E = 15.15) at MET 200 mg/L. Moreover, usage of higher concentrations of antibacterial agents revealed inhibitory effects. This study uncovers the optimum antibiotic combination therapy against cariogenic candida with FOA by usage of low therapeutic concentrations.

Kunstneriske Partnerskaber i den Åbne Skole?

DEFF Research Database (Denmark)

Haastrup, Lisbeth; Sørensen, Merete Cornet; Chemi, Tatiana

Rapporten er en videreførelse af "Effekten af børns og unges møde med kunst" og opstiller et overordnet forskningsdesign for projekter, hvor børn, unge, kunstnere, lærere og formidlere mødes om kunstneriske processer og læring. Forskningsdesignet baserer sig på to grundlæggende spørgsmål – dels...

Familiepleje i Danmark

DEFF Research Database (Denmark)

Bryderup, Inge; Engen, Mie; Kring, Sune

Familiepleje i Danmark handler om den danske familiepleje – om de familier, som vælger at blive familieplejere, og om de børn og unge, der er anbragt hos dem. Siden slutningen af 1980’erne har familiepleje været den mest anvendte anbringelsesform, når det gælder socialt udsatte børn og unge. Vi v...

 Gadeplansarbejdets grænseposition - muligheder og dilemmaer

DEFF Research Database (Denmark)

Mørck, Line Lerche

2010-01-01

Artiklen giver et bud på, hvordan vi gennem grænsefællesskaber på tværs af etniske og sociale skel kan bevæge det etablerede samfund og de unge, så de unge kommer 'indenfor rækkevidde'. Der diskuteres muligheder og dilemmaer i et gadeplansarbejde, der mødes med forventninger om at skulle samarbej...

Bedre veje til en ungdomsuddannelse

DEFF Research Database (Denmark)

Slotved, Mette; Hjermov, Pernille; Jensen, Vibeke Myrup

Formålet med delopgave 2 er at identificere praksisser, der er virkningsfulde i forhold til at få unge videre i ungdomsuddannelse eller beskæftigelse. Undersøgelsen retter således fokus på god praksis i forhold til målgruppen af unge mellem 16 og 25 år, som af faglige, personlige eller sociale år...

The Establishment of Barnahus in Denmark

DEFF Research Database (Denmark)

Søbjerg, Lene Mosegaard

2017-01-01

I 2013 blev fem børnehuse oprettet i Danmark med det formål at kvalificere og koordinere den indsats, der tilbydes børn og unge, der har været udsat for overgreb. Hensigten var at give børn og unge en helhedsorienteret indsats ved at samle flere offentlige instanser i et fælles hus. Kapitlet disk...

Chinese Cambodian Memory Work: Racial Terror and the Spaces of Haunting and Silence

OpenAIRE

Tea, Angela

2014-01-01

This thesis explores the terror and horror produced in the reification of ethnic classification and racial categorization of Chinese in Cambodia and its hauntings through memory works. This research relies on the memoirs of Luong Ung-Lai and Loung Ung and a performance piece by Jolie Chea. These cultural productions engages in the hauntings of memory and takes into consideration spaces of silence.

Elevoprør og studenteroprør i Danmark

DEFF Research Database (Denmark)

Nielsen, Knud Holt

iagttage flere større protestbølger blandt de danske unge. Rapporten påviser bl.a., at det er nødvendigt med en revurdering af den betydning, man ofte tillægger året 1968 og studenteroprøret. Perioden 1966-1971 markerer således ikke et klimaks for unge uddannelsessøgendes deltagelse i kollektive...

At navigere i usikkerhed, prekarisering og neoliberal beskæftigelsespolitik

DEFF Research Database (Denmark)

Gørlich, Anne

2016-01-01

Unge under 30 år som ikke har en ungdomsuddannelse får i dag et såkaldt ’uddannelsespålæg’, skifter kontanthjælpen ud med uddannelseshjælp og jobsøgning ud med uddannelsesafklaring. Skiftet fra velfærds- til konkurrencestat betyder, at alle unge under 30 år skal uddannes og gøres mere ’employable...... deres individuelle kompetencer og værdi og på den anden side et arbejdsmarked, som bliver mere og mere prekært. Jeg vil beskrive de politiske tiltag, som sætter rammerne for de unges veje mellem uddannelse, aktivering og arbejde og således også forsøge at konkretisere, hvad neoliberal...

Pure and Modified Co-Poly(amide-12-b-ethylene oxide Membranes for Gas Separation Studied by Molecular Investigations

Directory of Open Access Journals (Sweden)

Luana De Lorenzo

2012-06-01

Full Text Available This paper deals with a theoretical investigation of gas transport properties in a pure and modified PEBAX block copolymer membrane with N-ethyl-o/p-toluene sulfonamide (KET as additive molecules. Molecular dynamics simulations using COMPASS force field, Gusev-Suter Transition State Theory (TST and Monte Carlo methods were used. Bulk models of PEBAX and PEBAX/KET in different copolymer/additive compositions were assembled and analyzed to evaluate gas permeability and morphology to characterize structure-performance relationships.

Portræt af litteraturkritikeren som ungt menneske

DEFF Research Database (Denmark)

Schatz-Jakobsen, Claus

2004-01-01

Artiklen præsenterer den amerikanske litteraturkritiker Geoffrey Hartmans tidlige forfatterskab og fremdrager dets selvbiografiske undertekst som nødvendig effekt af den unge Hartmans fascination af den engelske romantiker William Wordsworths forfatterskab.......Artiklen præsenterer den amerikanske litteraturkritiker Geoffrey Hartmans tidlige forfatterskab og fremdrager dets selvbiografiske undertekst som nødvendig effekt af den unge Hartmans fascination af den engelske romantiker William Wordsworths forfatterskab....

Det levende og det levede

DEFF Research Database (Denmark)

Binder, Thomas

2006-01-01

Katalogtekst til udstillingen 'Honey, I'm home' på DDC, Dansk Design Center d. 02.03.2006-18.06.2006. En diskussion af de unges designeres tilgang til designrollen og det designede objekt.......Katalogtekst til udstillingen 'Honey, I'm home' på DDC, Dansk Design Center d. 02.03.2006-18.06.2006. En diskussion af de unges designeres tilgang til designrollen og det designede objekt....

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice

DEFF Research Database (Denmark)

Andersen, Sonja; Ericsson, Madelene; Dai, Hong Yan

2005-01-01

causes a significant reduction of T-helper cells, and 50% of the young Ung(-/-) mice investigated have no detectable NK/NKT-cell population in their spleen. The immunological imbalance is confirmed in experiments with spleen cells where the production of the cytokines interferon gamma, interleukin 6....... The immunological imbalances shown here in the Ung-deficient mice may be central in the development of lymphomas in a background of generalised lymphoid hyperplasia....

Prevalence of overweight in 2 to 17 year-old children and adolescents whose parents live separately

DEFF Research Database (Denmark)

Hohwü, Lena; Gissler, Mika; Sjöberg, Agneta

2014-01-01

Studiet baserer sig på projektet ’NordChild’, som er et nordisk samarbejde om sundhed og velvære blandt børn og unge i de nordiske lande. Formålet var at undersøge både forekomsten og sammenhængen mellem overvægt blandt børn og unge, hvis forældre levede hver for sig efter barnets fødsel. Inden f...

En Ung bank

OpenAIRE

Lind, Maria Benedicte; Rice, Harrie Emily; Andersen, Lærke Maria; Elfort, Amanda Josefine; Pedersen, Sophie Espe; Sahibzada, Qamar Un Nisa

2016-01-01

The purpose of this project is to examine the campaign Øhhkonomi from Danske Bank. The project is based on examining which assumptions the campaign, and further actions surrounding the campaign, expresses about the audience. The campaign audience is specifically 18-27 years old and addresses problems regarding their personal finance skills and understanding thereof. Starting from a communication point of view, the project examines the campaign and the sender in itself. The purpose hereof is t...

Die DDC auf neuen Wegen - verbale Sucheinstiege für klassifikatorisch erschlossene Titel

OpenAIRE

Christiane Maibach

2014-01-01

Die Dewey-Dezimalklassifikation (DDC) ist ein mächtiges Instrument der klassifikatorischen Inhaltserschließung. Immer mehr Bibliotheken im In- und Ausland erkennen den Nutzen der international am weitesten verbreiteten Universalklassifikation. Die Deutsche Nationalbibliothek (DNB) setzt die DDC seit 2006 für die inhaltliche Erschließung der Bibliografiereihen A, B und H ein. Seitdem wurden rund 800.000 Publikationen mit DDC-Notationen versehen. Der Nutzen von Klassifikationen ist unter Biblio...

Infrecuencia de la tricomoniasis como causa de uretritis masculina Estudio por cultivo

Directory of Open Access Journals (Sweden)

Federico Díaz G.

1983-09-01

Full Text Available En sólo 3 de 92 hombres (3.3% con uretritis no gonocócica (UNG se halló la Trichomonas vaginalis por cultivo; en dos de ellos el examen directo había revelado el parásito; estos resultados confirman la baja frecuencia, previamente informada, de este protozoo en casos de UNG y permiten proponer que el cultivo para Trichomonas no esta justificado en hombres con tal cuadro clínico.

Genomic uracil and human disease

DEFF Research Database (Denmark)

Hagen, Lars; Pena Diaz, Javier; Kavli, Bodil

2006-01-01

Uracil is present in small amounts in DNA due to spontaneous deamination of cytosine and incorporation of dUMP during replication. While deamination generates mutagenic U:G mismatches, incorporated dUMP results in U:A pairs that are not directly mutagenic, but may be cytotoxic. In most cells, mut...... retroviral infections. Ung(-/-) mice have a similar phenotype and develop B-cell lymphomas late in life. However, there is no evidence indicating that UNG deficiency causes lymphomas in humans....

Manuell grönsaksskärare

OpenAIRE

Langborg, Ida

2010-01-01

Denna rapport är en skriftlig sammanställning av det produktutvecklingsprojekt som gjorts som kandidatarbete inom programmet Design och produktframtagning KTH, under våren 2010. Köket är idag en viktig samlingspunkt för familjer och vänner och antalet köksredskap är oändligt många och anpassade till det moderna köket. Många redskap är stora, drivs av elektricitet för att effektivisera matlagningen och på så sätt spara tid, samtidigt som det ligger en trend i ekologi och energibesparing. Själv...

Hypersensitivity of hypoxia grown Mycobacterium smegmatis to DNA damaging agents: implications of the DNA repair deficiencies in attenuation of mycobacteria.

Science.gov (United States)

Rex, Kervin; Kurthkoti, Krishna; Varshney, Umesh

2013-10-01

Mycobacteria are an important group of pathogenic bacteria. We generated a series of DNA repair deficient strains of Mycobacterium smegmatis, a model organism, to understand the importance of various DNA repair proteins (UvrB, Ung, UdgB, MutY and Fpg) in survival of the pathogenic strains. Here, we compared tolerance of the M. smegmatis strains to genotoxic stress (ROS and RNI) under aerobic, hypoxic and recovery conditions of growth by monitoring their survival. We show an increased susceptibility of mycobacteria to genotoxic stress under hypoxia. UvrB deficiency led to high susceptibility of M. smegmatis to the DNA damaging agents. Ung was second in importance in strains with single deficiencies. Interestingly, we observed that while deficiency of UdgB had only a minor impact on the strain's susceptibility, its combination with Ung deficiency resulted in severe consequences on the strain's survival under genotoxic stress suggesting a strong interdependence of different DNA repair pathways in safeguarding genomic integrity. Our observations reinforce the possibility of targeting DNA repair processes in mycobacteria for therapeutic intervention during active growth and latency phase of the pathogen. High susceptibility of the UvrB, or the Ung/UdgB deficient strains to genotoxic stress may be exploited in generation of attenuated strains of mycobacteria. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

“El perfil sociocultural de los graduados universitarios: el caso de la UNGS”

OpenAIRE

Fernández, Marcos Silvestre

2015-01-01

La presente ponencia se enmarca en un proyecto de beca de investigación otorgada por Consejo Interuniversitario Nacional (CIN) en Octubre del 2014, en la carrera de grado Lic. En Educación de La Universidad Nacional de General Sarmiento (UNGS). El trabajo tiene como objetivo presentar el análisis, las metodologías empleadas y las primeras conclusiones sobre el estudio "El perfil Sociocultural de los graduados universitario: el caso de la UNGS". El proyecto se propuso elaborar un es...

I Kenya bliver lærergerningen et kald

DEFF Research Database (Denmark)

Henriksen, Carsten

2017-01-01

Når unge i Kenya starter på læreruddannelsen, ønsker de færreste af dem at blive lærer. Men i løbet af uddannelsen bliver profession og personlig identitet vævet sammen.......Når unge i Kenya starter på læreruddannelsen, ønsker de færreste af dem at blive lærer. Men i løbet af uddannelsen bliver profession og personlig identitet vævet sammen....

Use of Quantitative Uncertainty Analysis to Support M&VDecisions in ESPCs

Energy Technology Data Exchange (ETDEWEB)

Mathew, Paul A.; Koehling, Erick; Kumar, Satish

2005-05-11

Measurement and Verification (M&V) is a critical elementof an Energy Savings Performance Contract (ESPC) - without M&V, thereisno way to confirm that the projected savings in an ESPC are in factbeing realized. For any given energy conservation measure in an ESPC,there are usually several M&V choices, which will vary in terms ofmeasurement uncertainty, cost, and technical feasibility. Typically,M&V decisions are made almost solely based on engineering judgmentand experience, with little, if any, quantitative uncertainty analysis(QUA). This paper describes the results of a pilot project initiated bythe Department of Energy s Federal Energy Management Program to explorethe use of Monte-Carlo simulation to assess savings uncertainty andthereby augment the M&V decision-making process in ESPCs. The intentwas to use QUA selectively in combination with heuristic knowledge, inorder to obtain quantitative estimates of the savings uncertainty withoutthe burden of a comprehensive "bottoms-up" QUA. This approach was used toanalyze the savings uncertainty in an ESPC for a large federal agency.The QUA was seamlessly integrated into the ESPC development process andthe incremental effort was relatively small with user-friendly tools thatare commercially available. As the case study illustrates, in some casesthe QUA simply confirms intuitive or qualitative information, while inother cases, it provides insight that suggests revisiting the M&Vplan. The case study also showed that M&V decisions should beinformed by the portfolio risk diversification. By providing quantitativeuncertainty information, QUA can effectively augment the M&Vdecision-making process as well as the overall ESPC financialanalysis.

Identifying depression among adolescents using three key questions

DEFF Research Database (Denmark)

Haugen, Wenche; Haavet, Ole Rikard; Sirpal, Manjit Kaur

2016-01-01

Depression rammer mange voksne mennesker. Dette studie, som er omtalt i BMJ, viser, at et spørgeskema med blot tre spørgsmål ret præcist kan identificere voksne med depression. Undersøgelsen viser også, at de samme spørgsmål med fordel kan stilles verbalt ved diagnosticering af depression hos unge...... mennesker. Studiet ledsages af en redaktionel kommentar, der understreger betydningen af diagnosticering af depression hos mennesker. Mange unge har kun sjældent kontakt med deres praktiserende læge. Derfor kan mange gå i lang tid med depression, uden at det bliver opdaget og behandlet. De tre enkle...... spørgsmål, der kredser om interesse (eller mangel på interesse) for daglige aktiviteter og følelser som nedtrykthed eller håbløshed, kan være et godt pejlemærke for evt. depression hos unge, som ellers let kan blive overset....

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil–DNA glycosylase

Science.gov (United States)

Nilsen, Hilde; Haushalter, Karl A.; Robins, Peter; Barnes, Deborah E.; Verdine, Gregory L.; Lindahl, Tomas

2001-01-01

Gene-targeted mice deficient in the evolutionarily conserved uracil–DNA glycosylase encoded by the UNG gene surprisingly lack the mutator phenotype characteristic of bacterial and yeast ung– mutants. A complementary uracil–DNA glycosylase activity detected in ung–/– murine cells and tissues may be responsible for the repair of deaminated cytosine residues in vivo. Here, specific neutralizing antibodies were used to identify the SMUG1 enzyme as the major uracil–DNA glycosylase in UNG-deficient mice. SMUG1 is present at similar levels in cell nuclei of non-proliferating and proliferating tissues, indicating a replication- independent role in DNA repair. The SMUG1 enzyme is found in vertebrates and insects, whereas it is absent in nematodes, plants and fungi. We propose a model in which SMUG1 has evolved in higher eukaryotes as an anti-mutator distinct from the UNG enzyme, the latter being largely localized to replication foci in mammalian cells to counteract de novo dUMP incorporation into DNA. PMID:11483530

Anaesthesia of nyala (Tragelaphus angasi with a combination of thiafentanil (A3080, medetomidine and ketamine

Directory of Open Access Journals (Sweden)

D.V. Cooper

2005-06-01

Full Text Available A combination of thiafentanil (A3080, medetomidine hydrochloride (MED and ketamine hydrochloride (KET was evaluated in 19 boma-habituated (12 female and 7 males and 9 free-ranging nyala (7 male and 2 females (Tragelaphus angasi to develop a safe and reliable anaesthesia protocol. Wide dosages were used safely during this study with ranges for A3080 of 45 + 8 mg/kg with MED of 69 + 19 mg/kg and KET of 3.7 + 1.0 mg/kg (200 mg/ animal. The dosages developed on boma-habituated nyala proved to be equally effective in 9 adult free-ranging nyala (7 males and 2 females. The optimum dosage for nyala was a combination of A3080 (40-50 mg/kg, MED (60-80 mg/kg plus 200 mg of KET/animal. The anaesthesia was characterised by a short induction, good muscle relaxation and mild hypoxaemia during monitoring the anaesthesia was rapidly and completely reversed by naltrexone hydrochloride (30mg/mgof A3080 and atipamezole hydrochloride (5mg/mg of MED given intramuscularly. There was no mortality or morbidity associated with this protocol.

Peter Pan-demien

DEFF Research Database (Denmark)

Holm, Claus

2009-01-01

Ungdommelig opførsel er moderne. I gamle dage skulle vi blive voksne. I dag skal selv gamle mænd og kvinder holde sig unge. Peter Pan-panikken er i os, og en af vores væsentligste sociale lidelser er umodenhed.......Ungdommelig opførsel er moderne. I gamle dage skulle vi blive voksne. I dag skal selv gamle mænd og kvinder holde sig unge. Peter Pan-panikken er i os, og en af vores væsentligste sociale lidelser er umodenhed....

4 hovedproblemer med STU

DEFF Research Database (Denmark)

Jensen, Niels Rosendal

2012-01-01

Kommentaren oplister fire hovedproblemer ved den Særligt Tilrettelagte Ungdomsuddannelse, nemlig (1) beskrivelsen af målgruppen, (2) de unges forsørgelsesgrundlag, (3) hvad der følger efter én afsluttet STU, og (4) "lovjunglen" - manglende samspil mellem mange lovgivninger.......Kommentaren oplister fire hovedproblemer ved den Særligt Tilrettelagte Ungdomsuddannelse, nemlig (1) beskrivelsen af målgruppen, (2) de unges forsørgelsesgrundlag, (3) hvad der følger efter én afsluttet STU, og (4) "lovjunglen" - manglende samspil mellem mange lovgivninger....

Cuatrocientos setenta y siete casos de uretritis masculina

Directory of Open Access Journals (Sweden)

Federico Díaz González

1985-12-01

Full Text Available En el año de 1985 se estudiaron, desde el punto de vista del laboratorio, 477 casos de uretritis masculina; 49 de ellos (10.3% fueron de uretritis gonocócica (UG y 428 (89.7% de uretritis no gonocócica (UNG. Estos resultados concuerdan con los obtenidos en series previas; se discute la importancia de la UNG y se plantea la posibilidad de que muchos de los casos de esta entidad sean de la modalidad postgonocócica (UPG.

Boost læringen med levende billeder

DEFF Research Database (Denmark)

Christensen, Ole

2016-01-01

Børn og unge lever i en digital virkelighed, og det er helt afgørende, at skolerne møder denne virkelighed. Medierne har nemlig både potentialet for at understøtte og udfordre den pædagogiske praksis......Børn og unge lever i en digital virkelighed, og det er helt afgørende, at skolerne møder denne virkelighed. Medierne har nemlig både potentialet for at understøtte og udfordre den pædagogiske praksis...

Tiden kræver nye karakteregenskaber

DEFF Research Database (Denmark)

Holm, Claus

2013-01-01

I Danmark har vi tradition for, at unges studievalg er styret af faglig interesse og lyst. Men en ny global konkurrencetilstand kræver, at lysten også omfatter vilje til at udføre kedsommelige pligter som moderne og fleksible medarbejdere......I Danmark har vi tradition for, at unges studievalg er styret af faglig interesse og lyst. Men en ny global konkurrencetilstand kræver, at lysten også omfatter vilje til at udføre kedsommelige pligter som moderne og fleksible medarbejdere...

"a view of life" - 18.-30.9.2007 (Sisimiut Museum, Grønland)

DEFF Research Database (Denmark)

Medonos, Jakub Christensen

2007-01-01

Udstilling af og om unge i Sisimiut, Grønland. I Forbindelse med forskningsprojektet; "Ungdom og urbanitet i Grønland - en undersøgelse af den urbane ungdomskultur i Sisimiut: kompetencer, kreativitet og visioner." Se: www.workshop2007.wordpress.com  ......Udstilling af og om unge i Sisimiut, Grønland. I Forbindelse med forskningsprojektet; "Ungdom og urbanitet i Grønland - en undersøgelse af den urbane ungdomskultur i Sisimiut: kompetencer, kreativitet og visioner." Se: www.workshop2007.wordpress.com  ...

The computer disappears, the environment becomes smart

NARCIS (Netherlands)

Leeuwen, van h. (Henk)

2011-01-01

Contribution to exhibition Qua Art - Qua Science. The artist Joost Verhagen represents spaces in an original way by using colours, texture and forms. He invokes thoughts and feelings with his works of art. The concept of ambient intelligence also deals with space, but especially with spaces that are

Karakterer dumper som sorteringsværktøj

DEFF Research Database (Denmark)

Middelboe, Vibe Abildtrup

2016-01-01

To statistikforskere vender tommelfingeren nedad til de nye karakterkrav til ungdomsuddannelserne. Det er for tidligt at dele de unge op i dem, der kan få en uddannelse, og dem, der ikke kan, og hverken karakterer eller afgangsprøve er gearet til det.......To statistikforskere vender tommelfingeren nedad til de nye karakterkrav til ungdomsuddannelserne. Det er for tidligt at dele de unge op i dem, der kan få en uddannelse, og dem, der ikke kan, og hverken karakterer eller afgangsprøve er gearet til det....

Eku Otung : theatrical and transcendental celebration of death ...

African Journals Online (AJOL)

Among the Qua/Ejagham speaking people of Cross River State Nigeria, Death is celebrated and even more elaborate are the rites, rituals and celebrations especially when dignitaries and royalties are involved. Looking at the funeral rites of the kings of the Qua/Ejgham speaking people, this rite commonly known as the Eku ...

Unge uledsagede flygtninges stemmer

DEFF Research Database (Denmark)

2017-01-01

Valg af materiale/medie/form: Powerpoint Valg af arbejdsform: Oplæg til workshop Begrundelse for valg af materiale/medie/form/arbejdsform: Fungerer godt i den sammenhæng......Valg af materiale/medie/form: Powerpoint Valg af arbejdsform: Oplæg til workshop Begrundelse for valg af materiale/medie/form/arbejdsform: Fungerer godt i den sammenhæng...

Unge, holdspil og medborgerskab

DEFF Research Database (Denmark)

Ryom, Knud

for at lykkes. Dermed sy-nes der behov for indsatser, der kan styrke denne gruppe af drenge, så de oplever handlekompeten-cer, som kan betyde, at de kan agere på nye måder. At udvikle sig som menneske behøver ikke anses som et individuelt projekt, derfor søger denne afhandling at lægge vægt på fællesskabet, og...

Chemical capture of free-ranging red deer (Cervus elaphus with medetomidine-ketamine

Directory of Open Access Journals (Sweden)

J.M. Arnemo

1994-12-01

Full Text Available Seventeen free-ranging red deer (Cervus elaphus (12 calves and 5 yearling hinds were immobilized with a combination of medetomidine hydrochloride (MED and ketamine hydrochloride (KET in winter (January-March. Immobilizations were performed with plastic projectile syringes fired from a dart gun. Mean (SD doses of 0.147 (0.024 mg MED/kg and 2.5 (0.4 mg KET/kg induced recumbency in 5.0 (2.0 minutes in the calves and all of them were completely immobilized. The initial doses in the yearling hinds were 0.099 (0.016 mg MED/kg and 1.9 (0.2 mg KET/kg but three of them required addirional dosing for induction of reliable restraint. The distance covered by the animals between darting and recumbency ranged from 40-250 m for calves and 100-300 m for yearling hinds. The animals were translocated to deer farms for breeding purposes and were given 12.5-25.0 mg of atipamezole hydrochloride before transportation. All animals recovered completely. Haematological and serum biochemical comparisons between free-ranging calves immobilized with medetomidine-ketamine (n=3 and captive unmedicated calves (n=4 showed that chemical capture induce very little stress in red deer.

Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers

Directory of Open Access Journals (Sweden)

Xinkuan Liu

2018-03-01

Full Text Available Nanomaterials providing sustained release profiles are highly desired for efficacious drug delivery. Advanced nanotechnologies are useful tools for creating elaborate nanostructure-based nanomaterials to achieve the designed functional performances. In this research, a modified coaxial electrospinning was explored to fabricate a novel core-sheath nanostructure (nanofibers F2, in which a sheath drug-free gliadin layer was successfully coated on the core ketoprofen (KET-gliadin nanocomposite. A monolithic nanocomposite (nanofibers F1 that was generated through traditional blending electrospinning of core fluid was utilized as a control. Scanning electron microscopy demonstrated that both nanofibers F1 and F2 were linear. Transmission electron microscopy verified that nanofibers F2 featured a clear core-sheath nanostructure with a thin sheath layer about 25 nm, whereas their cores and nanofibers F1 were homogeneous KET-gliadin nanocomposites. X-ray diffraction patterns verified that, as a result of fine compatibility, KET was dispersed in gliadin in an amorphous state. In vitro dissolution tests demonstrated that the thin blank nanocoating in nanofibers F2 significantly modified drug release kinetics from a traditional exponential equation of nanofibers F1 to a zero-order controlled release model, linearly freeing 95.7 ± 4.7% of the loaded cargoes over a time period of 16 h.

Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers.

Science.gov (United States)

Liu, Xinkuan; Shao, Wenyi; Luo, Mingyi; Bian, Jiayin; Yu, Deng-Guang

2018-03-22

Nanomaterials providing sustained release profiles are highly desired for efficacious drug delivery. Advanced nanotechnologies are useful tools for creating elaborate nanostructure-based nanomaterials to achieve the designed functional performances. In this research, a modified coaxial electrospinning was explored to fabricate a novel core-sheath nanostructure (nanofibers F2), in which a sheath drug-free gliadin layer was successfully coated on the core ketoprofen (KET)-gliadin nanocomposite. A monolithic nanocomposite (nanofibers F1) that was generated through traditional blending electrospinning of core fluid was utilized as a control. Scanning electron microscopy demonstrated that both nanofibers F1 and F2 were linear. Transmission electron microscopy verified that nanofibers F2 featured a clear core-sheath nanostructure with a thin sheath layer about 25 nm, whereas their cores and nanofibers F1 were homogeneous KET-gliadin nanocomposites. X-ray diffraction patterns verified that, as a result of fine compatibility, KET was dispersed in gliadin in an amorphous state. In vitro dissolution tests demonstrated that the thin blank nanocoating in nanofibers F2 significantly modified drug release kinetics from a traditional exponential equation of nanofibers F1 to a zero-order controlled release model, linearly freeing 95.7 ± 4.7% of the loaded cargoes over a time period of 16 h.

Det finnes ingen gangstere i Norge

OpenAIRE

Gresaker, Ann Kristin

2007-01-01

Denne oppgaven handler om åtte gutters forhold til rapmusikk. Jeg har intervjuet åtte gutter/unge menn med minoritetsbakgrunn som bor eller har bodd store deler av livet sitt på østkanten i Oslo. Informantene er i alderen mellom 17 og 24 år og alle har et spesielt forhold til rapmusikk. Syv av de åtte rapper selv på ulike nivå og med ulike ambisjoner. Problemstillingen jeg søker å svare på er todelt, og første del lyder: Hvilke dominerende fortellinger om hiphop/rap finner vi hos gutter/unge ...

"Non qua servus est, sed qua homo." Der rechtliche Status von Sklaven bei Luis de Molina

OpenAIRE

Simmermacher, Danaë

2014-01-01

Luis de Molina (1535-1600) grants slaves a legal status through which they can take up a position with respect to their masters between equivalent legal entity and legal object. Here, what is decisive is the figure of the subjective right, which both for Molina and modern proponents of this legal concept describes the 'right per se'. According to Molina's definition of ius, the denial of a subjective right or the hindrance of exercising an individual right represents an injustice. The rights ...

Inner products of resonance solutions in 1D quantum barriers

Energy Technology Data Exchange (ETDEWEB)

Julve, J [IFF, Consejo Superior de Investigaciones CientIficas, Serrano 113 bis, Madrid 28006 (Spain); De Urries, F J, E-mail: julve@imaff.cfmac.csic.e, E-mail: fernando.urries@uah.e [Departamento de Fisica, Universidad de Alcala de Henares, Alcala de Henares, Madrid (Spain)

2010-04-30

The properties of a prescription for the inner products of resonance (Gamow states), scattering (Dirac kets) and bound states for one-dimensional quantum barriers are worked out. The divergent asypmtotic behaviour of the Gamow states is regularized using a Gaussian convergence factor first introduced by Zel'dovich. With this prescription, most of these states (with discrete complex energies) are found to be orthogonal to each other and to the Dirac kets, except when they are neighbours, in which case the inner product is divergent. Therefore, as it happens for the continuum scattering states, the norm of the resonant ones remains non-calculable. Thus, they exhibit properties halfway between the (continuum real) Dirac-{delta} orthogonality and the (discrete real) Kronecker-{delta} orthogonality of the bound states.

Error-free versus mutagenic processing of genomic uracil--relevance to cancer.

Science.gov (United States)

Krokan, Hans E; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik Sahlin; Kavli, Bodil; Slupphaug, Geir

2014-07-01

Genomic uracil is normally processed essentially error-free by base excision repair (BER), with mismatch repair (MMR) as an apparent backup for U:G mismatches. Nuclear uracil-DNA glycosylase UNG2 is the major enzyme initiating BER of uracil of U:A pairs as well as U:G mismatches. Deficiency in UNG2 results in several-fold increases in genomic uracil in mammalian cells. Thus, the alternative uracil-removing glycosylases, SMUG1, TDG and MBD4 cannot efficiently complement UNG2-deficiency. A major function of SMUG1 is probably to remove 5-hydroxymethyluracil from DNA with general back-up for UNG2 as a minor function. TDG and MBD4 remove deamination products U or T mismatched to G in CpG/mCpG contexts, but may have equally or more important functions in development, epigenetics and gene regulation. Genomic uracil was previously thought to arise only from spontaneous cytosine deamination and incorporation of dUMP, generating U:G mismatches and U:A pairs, respectively. However, the identification of activation-induced cytidine deaminase (AID) and other APOBEC family members as DNA-cytosine deaminases has spurred renewed interest in the processing of genomic uracil. Importantly, AID triggers the adaptive immune response involving error-prone processing of U:G mismatches, but also contributes to B-cell lymphomagenesis. Furthermore, mutational signatures in a substantial fraction of other human cancers are consistent with APOBEC-induced mutagenesis, with U:G mismatches as prime suspects. Mutations can be caused by replicative polymerases copying uracil in U:G mismatches, or by translesion polymerases that insert incorrect bases opposite abasic sites after uracil-removal. In addition, kataegis, localized hypermutations in one strand in the vicinity of genomic rearrangements, requires APOBEC protein, UNG2 and translesion polymerase REV1. What mechanisms govern error-free versus error prone processing of uracil in DNA remains unclear. In conclusion, genomic uracil is an

The Ulysses fast latitude scans: COSPIN/KET results

Directory of Open Access Journals (Sweden)

B. Heber

2003-06-01

Full Text Available Ulysses, launched in October 1990, began its second out-of-ecliptic orbit in December 1997, and its second fast latitude scan in September 2000. In contrast to the first fast latitude scan in 1994/1995, during the second fast latitude scan solar activity was close to maximum. The solar magnetic field reversed its polarity around July 2000. While the first latitude scan mainly gave a snapshot of the spatial distribution of galactic cosmic rays, the second one is dominated by temporal variations. Solar particle increases are observed at all heliographic latitudes, including events that produce >250 MeV protons and 50 MeV electrons. Using observations from the University of Chicago’s instrument on board IMP8 at Earth, we find that most solar particle events are observed at both high and low latitudes, indicating either acceleration of these particles over a broad latitude range or an efficient latitudinal transport. The latter is supported by "quiet time" variations in the MeV electron background, if interpreted as Jovian electrons. No latitudinal gradient was found for >106 MeV galactic cosmic ray protons, during the solar maximum fast latitude scan. The electron to proton ratio remains constant and has practically the same value as in the previous solar maximum. Both results indicate that drift is of minor importance. It was expected that, with the reversal of the solar magnetic field and in the declining phase of the solar cycle, this ratio should increase. This was, however, not observed, probably because the transition to the new magnetic cycle was not completely terminated within the heliosphere, as indicated by the Ulysses magnetic field and solar wind measurements. We argue that the new A<0-solar magnetic modulation epoch will establish itself once both polar coronal holes have developed.Key words. Interplanetary physics (cosmic rays; energetic particles; interplanetary magnetic fields

Fremmed, farlig og fræk

DEFF Research Database (Denmark)

Jensen, Sune Qvotrup

fiksering, ved at påberåbe sig normalitet eller ved at ironisere over stereotyper. Modstanden mod othering i forskningsrelationen kan tolkes som en påberåbelse af at være et 'almindeligt menneske'. Men modstanden, mod at blive fastlåst i den position man selv iscenesætter peger også på en kompetence til...... rolleskift. De unge forsøger selv at bestemme, hvornår de vil fremstille sig selv på en stereotyp måde, og hvornår de vil være fri for at blive betragtet gennem stereotypiens patologiserende optik. Analysen af fortællingerne om hverdagsliv og othering viser, at enisk/racial andenhed kommer til at få en...... praksis uden for disse kontekster, må man principielt være forsigtig med at udtale sig. Men det kunne se ud til, at denne er temmelig differentieret. Nogle af de unge mænd er dominerende, måske ligefrem voldelige, mens andre ikke er det. En del af de unge positionerer sig homofobisk, idet de tager stærk...

The Organization Pattern of Root Border-Like Cells of Arabidopsis Is Dependent on Cell Wall Homogalacturonan12[C][W

Science.gov (United States)

Durand, Caroline; Vicré-Gibouin, Maïté; Follet-Gueye, Marie Laure; Duponchel, Ludovic; Moreau, Myriam; Lerouge, Patrice; Driouich, Azeddine

2009-01-01

Border-like cells are released by Arabidopsis (Arabidopsis thaliana) root tips as organized layers of several cells that remain attached to each other rather than completely detached from each other, as is usually observed in border cells of many species. Unlike border cells, cell attachment between border-like cells is maintained after their release into the external environment. To investigate the role of cell wall polysaccharides in the attachment and organization of border-like cells, we have examined their release in several well-characterized mutants defective in the biosynthesis of xyloglucan, cellulose, or pectin. Our data show that among all mutants examined, only quasimodo mutants (qua1-1 and qua2-1), which have been characterized as producing less homogalacturonan, had an altered border-like cell phenotype as compared with the wild type. Border-like cells in both lines were released as isolated cells separated from each other, with the phenotype being much more pronounced in qua1-1 than in qua2-1. Further analysis of border-like cells in the qua1-1 mutant using immunocytochemistry and a set of anti-cell wall polysaccharide antibodies showed that the loss of the wild-type phenotype was accompanied by (1) a reduction in homogalacturonan-JIM5 epitope in the cell wall of border-like cells, confirmed by Fourier transform infrared microspectrometry, and (2) the secretion of an abundant mucilage that is enriched in xylogalacturonan and arabinogalactan-protein epitopes, in which the cells are trapped in the vicinity of the root tip. PMID:19448034

Diameter dependent electron transfer kinetics in semiconductor-enzyme complexes.

Science.gov (United States)

Brown, Katherine A; Song, Qing; Mulder, David W; King, Paul W

2014-10-28

Excited state electron transfer (ET) is a fundamental step for the catalytic conversion of solar energy into chemical energy. To understand the properties controlling ET between photoexcited nanoparticles and catalysts, the ET kinetics were measured for solution-phase complexes of CdTe quantum dots and Clostridium acetobutylicum [FeFe]-hydrogenase I (CaI) using time-resolved photoluminescence spectroscopy. Over a 2.0-3.5 nm diameter range of CdTe nanoparticles, the observed ET rate (kET) was sensitive to CaI concentration. To account for diameter effects on CaI binding, a Langmuir isotherm and two geometric binding models were created to estimate maximal CaI affinities and coverages at saturating concentrations. Normalizing the ET kinetics to CaI surface coverage for each CdTe diameter led to k(ET) values that were insensitive to diameter, despite a decrease in the free energy for photoexcited ET (ΔGET) with increasing diameter. The turnover frequency (TOF) of CaI in CdTe-CaI complexes was measured at several molar ratios. Normalization for diameter-dependent changes in CaI coverage showed an increase in TOF with diameter. These results suggest that k(ET) and H2 production for CdTe-CaI complexes are not strictly controlled by ΔG(ET) and that other factors must be considered.

Predicting the Rate Constant of Electron Tunneling Reactions at the CdSe-TiO2 Interface.

Science.gov (United States)

Hines, Douglas A; Forrest, Ryan P; Corcelli, Steven A; Kamat, Prashant V

2015-06-18

Current interest in quantum dot solar cells (QDSCs) motivates an understanding of the electron transfer dynamics at the quantum dot (QD)-metal oxide (MO) interface. Employing transient absorption spectroscopy, we have monitored the electron transfer rate (ket) at this interface as a function of the bridge molecules that link QDs to TiO2. Using mercaptoacetic acid, 3-mercaptopropionic acid, 8-mercaptooctanoic acid, and 16-mercaptohexadecanoic acid, we observe an exponential attenuation of ket with increasing linker length, and attribute this to the tunneling of the electron through the insulating linker molecule. We model the electron transfer reaction using both rectangular and trapezoidal barrier models that have been discussed in the literature. The one-electron reduction potential (equivalent to the lowest unoccupied molecular orbital) of each molecule as determined by cyclic voltammetry (CV) was used to estimate the effective barrier height presented by each ligand at the CdSe-TiO2 interface. The electron transfer rate (ket) calculated for each CdSe-ligand-TiO2 interface using both models showed the results in agreement with the experimentally determined trend. This demonstrates that electron transfer between CdSe and TiO2 can be viewed as electron tunneling through a layer of linking molecules and provides a useful method for predicting electron transfer rate constants.

Determination of stable cesium and strontium in rice samples by inductively coupled plasma mass spectrometry

Science.gov (United States)

Srinuttrakul, W.; Yoshida, S.

2017-06-01

For long-term radiation dose assessment models, food ingestion is one of the major exposure pathways to human. In general, the stable isotopes can serve as analogues of radioisotopes. In this study, rice samples were collected from 30 paddy fields in Si Sa Ket, Yasothon and Roi Et in the northeast of Thailand in November 2014. The concentrations of stable cesium (Cs-133) and strontium (Sr-88) in polished rice were determined by inductively coupled plasma mass spectrometry (ICP-MS). The standard reference material of rice flour (NIST 1568a) with spiked Cs and Sr was used to validate the analytical method. The concentration of Cs in polished rice from Si Sa Ket, Yasothon and Roi Et was 0.158 ± 0.167 mg kg-1, 0.090 ± 0.117 mg kg-1 and 0.054 ± 0.031 mg kg-1, respectively. The concentration of Sr in polished rice from Si Sa Ket, Yasothon and Roi Et was 0.351 ± 0.108 mg kg-1, 0.364 ± 0.215 mg kg-1 and 0.287 ± 0.102 mg kg-1, respectively. Comparison of the results with Japanese data before the Fukushima Di-ichi nuclear power plant accident showed that the concentrations of both Cs and Sr for Thai rice were higher than those for Japanese rice.

Determination of stable cesium and strontium in rice samples by inductively coupled plasma mass spectrometry

International Nuclear Information System (INIS)

Srinuttrakul, W; Yoshida, S

2017-01-01

For long-term radiation dose assessment models, food ingestion is one of the major exposure pathways to human. In general, the stable isotopes can serve as analogues of radioisotopes. In this study, rice samples were collected from 30 paddy fields in Si Sa Ket, Yasothon and Roi Et in the northeast of Thailand in November 2014. The concentrations of stable cesium (Cs-133) and strontium (Sr-88) in polished rice were determined by inductively coupled plasma mass spectrometry (ICP-MS). The standard reference material of rice flour (NIST 1568a) with spiked Cs and Sr was used to validate the analytical method. The concentration of Cs in polished rice from Si Sa Ket, Yasothon and Roi Et was 0.158 ± 0.167 mg kg -1 , 0.090 ± 0.117 mg kg -1 and 0.054 ± 0.031 mg kg -1 , respectively. The concentration of Sr in polished rice from Si Sa Ket, Yasothon and Roi Et was 0.351 ± 0.108 mg kg -1 , 0.364 ± 0.215 mg kg -1 and 0.287 ± 0.102 mg kg -1 , respectively. Comparison of the results with Japanese data before the Fukushima Di-ichi nuclear power plant accident showed that the concentrations of both Cs and Sr for Thai rice were higher than those for Japanese rice. (paper)

Measuring postural control during mini-squat posture in men with early knee osteoarthritis.

Science.gov (United States)

Petrella, M; Gramani-Say, K; Serrão, P R M S; Lessi, G C; Barela, J A; Carvalho, R P; Mattiello, S M

2017-04-01

Studies have suggested a compromised postural control in individuals with knee osteoarthritis (OA) evidenced by larger and faster displacement of center of pressure (COP). However, quantification of postural control in the mini-squat posture performed by patients with early knee OA and its relation to muscle strength and self-reported symptoms have not been investigated. The main aim of this cross-sectional, observational, controlled study was to determine whether postural control in the mini-squat posture differs between individuals with early knee OA and a control group (CG) and verify the relation among knee extensor torque (KET) and self-reported physical function, stiffness and pain. Twenty four individuals with knee OA grades I and II (OAG) (mean age: 52.35±5.00) and twenty subjects without knee injuries (CG) (mean age: 51.40±8.07) participated in this study. Participants were assessed in postural control through a force plate (Bertec Mod. USA), which provided information about the anterior-posterior (AP) and medial-lateral (ML) COP displacement during the mini-squat, in isometric, concentric and eccentric knee extensor torque (KET) (90°/s) through an isokinetic dynamometer (BiodexMulti-Joint System3, Biodex Medical Incorporation, New York, NY, USA), and in self-reported symptoms through the WOMAC questionnaire. The main outcomes measured were the AP and ML COP amplitude and velocity of displacement; isometric, concentric, and eccentric KET and self-reported physical function, stiffness and pain. No significant differences were found between groups for postural control (p>0.05). Significant lower eccentric KET (p=0.01) and higher scores for the WOMAC subscales of pain (p=postural instability and the need to include quadriceps muscle strengthening, especially by eccentric contractions. The relationship between the self-reported symptoms and a lower and slower COP displacement suggest that the postural control strategy during tasks with a semi-flexed knee

Multiple-trait estimates of genetic parameters for metabolic disease traits, fertility disorders, and their predictors in Canadian Holsteins.

Science.gov (United States)

Jamrozik, J; Koeck, A; Kistemaker, G J; Miglior, F

2016-03-01

Producer-recorded health data for metabolic disease traits and fertility disorders on 35,575 Canadian Holstein cows were jointly analyzed with selected indicator traits. Metabolic diseases included clinical ketosis (KET) and displaced abomasum (DA); fertility disorders were metritis (MET) and retained placenta (RP); and disease indicators were fat-to-protein ratio, milk β-hydroxybutyrate, and body condition score (BCS) in the first lactation. Traits in first and later (up to fifth) lactations were treated as correlated in the multiple-trait (13 traits in total) animal linear model. Bayesian methods with Gibbs sampling were implemented for the analysis. Estimates of heritability for disease incidence were low, up to 0.06 for DA in first lactation. Among disease traits, the environmental herd-year variance constituted 4% of the total variance for KET and less for other traits. First- and later-lactation disease traits were genetically correlated (from 0.66 to 0.72) across all traits, indicating different genetic backgrounds for first and later lactations. Genetic correlations between KET and DA were relatively strong and positive (up to 0.79) in both first- and later-lactation cows. Genetic correlations between fertility disorders were slightly lower. Metritis was strongly genetically correlated with both metabolic disease traits in the first lactation only. All other genetic correlations between metabolic and fertility diseases were statistically nonsignificant. First-lactation KET and MET were strongly positively correlated with later-lactation performance for these traits due to the environmental herd-year effect. Indicator traits were moderately genetically correlated (from 0.30 to 0.63 in absolute values) with both metabolic disease traits in the first lactation. Smaller and mostly nonsignificant genetic correlations were among indicators and metabolic diseases in later lactations. The only significant genetic correlations between indicators and fertility

Õnnelik sümbioos / Ere Naat

Index Scriptorium Estoniae

Naat, Ere

2010-01-01

Anneli Tammiku, Ketli Tiitsari ja Maria Valdma ehtenäitus "Õnnelikud inimesed" Kärdla elektrijaamas (Vabaduse t. 2) 27. juulist 8. augustini 2010. Kõik ehted on valminud kolme kunstniku koostöös

Tensor analysis and elementary differential geometry for physicists and engineers

CERN Document Server

Nguyen-Schäfer, Hung

2014-01-01

Tensors and methods of differential geometry are very useful mathematical tools in many fields of modern physics and computational engineering including relativity physics, electrodynamics, computational fluid dynamics (CFD), continuum mechanics, aero and vibroacoustics, and cybernetics. This book comprehensively presents topics, such as bra-ket notation, tensor analysis, and elementary differential geometry of a moving surface. Moreover, authors intentionally abstain from giving mathematically rigorous definitions and derivations that are however dealt with as precisely as possible. The reader is provided with hands-on calculations and worked-out examples at which he will learn how to handle the bra-ket notation, tensors and differential geometry and to use them in the physical and engineering world. The target audience primarily comprises graduate students in physics and engineering, research scientists, and practicing engineers.

F.F.F.F. / Pille Väljataga

Index Scriptorium Estoniae

Väljataga, Pille

2001-01-01

Rühmituse F.F.F.F. (Berit Teeäär, Maria Valdma, Ketli Tiitsar, Kaire Rannik, Kristi Paap) esinemisest 2000. a. suvel Leedus Niida kunstnike majas. Ehteid eksponeeriti kõrvuti nende 20-kordse suurendusega fotodega.

Andestamine või kättemaks?

Index Scriptorium Estoniae

2013-01-01

INSEAD'i juhtimisprofessori Manfred F. R. Kets de Vries' analüüsist "The Art of Forgiveness: Differentiating Transformational Leaders", mis tugineb Lõuna-Aafrika Vabariigi juhi Nelson Mandela ja Zimbabwe juhi Robert Mugabe näidetele

Modelling the turbulent transport of angular momentum in tokamak plasmas - A quasi-linear gyrokinetic approach

International Nuclear Information System (INIS)

Cottier, Pierre

2013-01-01

The magnetic confinement in tokamaks is for now the most advanced way towards energy production by nuclear fusion. Both theoretical and experimental studies showed that rotation generation can increase its performance by reducing the turbulent transport in tokamak plasmas. The rotation influence on the heat and particle fluxes is studied along with the angular momentum transport with the quasi-linear gyro-kinetic eigenvalue code QuaLiKiz. For this purpose, the QuaLiKiz code is modified in order to take the plasma rotation into account and compute the angular momentum flux. It is shown that QuaLiKiz framework is able to correctly predict the angular momentum flux including the E*B shear induced residual stress as well as the influence of rotation on the heat and particle fluxes. The major approximations of QuaLiKiz formalisms are reviewed, in particular the ballooning representation at its lowest order and the eigenfunctions calculated in the hydrodynamic limit. The construction of the quasi-linear fluxes is also reviewed in details and the quasi-linear angular momentum flux is derived. The different contributions to the turbulent momentum flux are studied and successfully compared both against non-linear gyro-kinetic simulations and experimental data. (author) [fr

Nutritional composition of five food trees species products used in ...

African Journals Online (AJOL)

SAM

2014-04-23

Apr 23, 2014 ... Industrielle et Bioinformatique, UFR Sciences de la Vie et de la Terre, ... Consumption of these tree products can help to overcome nutrients deficiency that is ..... ket place Innovation and the National Institute for Agricul-.

Evaluering af Tysklands 0-promillegrænse for nye motorførere

DEFF Research Database (Denmark)

Sørensen, Poul Lyk; Bernhoft, Inger Marie

2012-01-01

Den 1. august 2007 blev der indført totalforbud i Tyskland mod indtagelse af alkohol i forbindelse med bilkørsel for alle nyuddannede motorførere i den (normalt) toårige prøvetid og/eller alle unge under 21 år. Effekten af tiltaget er evalueret af Bundesanstalt für Strassenwesen (BASt).......Den 1. august 2007 blev der indført totalforbud i Tyskland mod indtagelse af alkohol i forbindelse med bilkørsel for alle nyuddannede motorførere i den (normalt) toårige prøvetid og/eller alle unge under 21 år. Effekten af tiltaget er evalueret af Bundesanstalt für Strassenwesen (BASt)....

What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

Science.gov (United States)

Niu, Kai; Lee, Soo-Y.

2015-12-01

Coherent anti-Stokes Raman spectroscopy (CARS) is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

International Nuclear Information System (INIS)

Niu, Kai; Lee, Soo-Y.

2015-01-01

Coherent anti-Stokes Raman spectroscopy (CARS) is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms

What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

Energy Technology Data Exchange (ETDEWEB)

Niu, Kai [School of Science, Tianjin University of Technology and Education, Tianjin, 300222 (China); Lee, Soo-Y., E-mail: sooying@ntu.edu.sg [Division of Physics & Applied Physics, and Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)

2015-12-15

Coherent anti-Stokes Raman spectroscopy (CARS) is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

JCSC_129_09_1441_1448_SI.docx

Indian Academy of Sciences (India)

shridhar

Dighe College of Science, Bhandup (E), Mumbai - 400042, INDIA. cHomi Bhabha Centre for Science Education (TIFR), Mankhurd, Mumbai-400088, INDIA. dDepartment of Chemistry, K.E.T's V.G. Vaze College of Arts, Science and Commerce, ...

Domestic and Foreign Effects on Prices in an Open Economy

DEFF Research Database (Denmark)

Juselius, Katarina

1994-01-01

Domestic price determination in Denmark is investigated using three kinds of macro-economic explanations: (1) internal labor mar­ ket theories describing the relation between price and wage inflation, (2) pure monetarist theories describing the effect of excess money on the inflation rate, and (3...... model. The results stand up as quite strong evidence against the Lucas critiqueDomestic price determination in Denmark is investigated using three kinds of macro-economic explanations: (1) internal labor mar­ ket theories describing the relation between price and wage inflation, (2) pure monetarist...... found to be the main determinants of the inflation rate. Among these, the domestic effects were small compared to the foreign effects. The em­ pirical results strongly favored a backward-looking behavioral model in terms of structurally stable parameters as opposed to a forward- looking expectations...

Combustion of Solid Propellants (La Combustion des Propergols Solides)

Science.gov (United States)

1991-07-01

the of ether and ethyl alcohol and removing objective of these lectures to give a this solvent. Instead of having a fibrous comprehensive understanding...do cetto esrne do Les propergols composites, A matrice confifrences une description tout A fait A polymarique charg~o pst, un oxydant at un jour des...rusa., De nouveaux souvant suppos6 qua la vitesa des gaz de oxydes de for ultrafirts mont aujourd’hui combustion est n~gligeable at qua d~velopps pour

F.F.F.F. armastab mõtestada ennast / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2002-01-01

Rühmituse F.F.F.F. (Kristi Paap, Kaire Rannik, Berit Teeäär, Ketli Tiitsar, Maria Valdma) näitus "Meie igapäevane leib" 9. novembrini Hansapanga galeriis ja näitus "Pentagramm" 26. X-1. XII Tarbekunstimuuseumis

The Tower: Modelling, Analysis and Construction of Bending Active Tensile Membrane Hybrid Structures

DEFF Research Database (Denmark)

Holden Deleuran, Anders; Schmeck, Michel; Charles Quinn, Gregory

2015-01-01

The project is the result of an interdisciplinary research collaboration between CITA, KET and Fibrenamics exploring the design of integrated hybrid structures employing bending active elements and tensile membranes with bespoke material properties and detailing. Hybrid structures are defined her...

Kaheksas ehtenäitus sel hooajal / Kai Lobjakas

Index Scriptorium Estoniae

Lobjakas, Kai, 1975-

1999-01-01

18. VI-8. VIII Tarbekunstimuuseumis rahvusvaheline ehtekunstinäitus "Meele Avaldus/Mind Seduction". Osalema on kutsutud 30 noort ehtekunstnikku seitsmest Euroopa riigist. Kuraator ja kujundaja Ketli Tiitsar. Eestit esindavad rühmituse F.F.F.F. liikmed, Mari ja Adolfas Shaulys

SUPPLEMENTARY INFORMATION Dimethylglyoxime as an ...

Indian Academy of Sciences (India)

lenovo

1. SUPPLEMENTARY INFORMATION. Dimethylglyoxime as an Efficient Ligand for Copper-Catalyzed Hydroxylation of Aryl. Halides. SURESH S SHENDAGE*. Department of Chemistry, KET'S Vinayak Ganesh Vaze College of Arts, Science and. Commerce, Mithagar Road, Mulund (E) Mumbai, Maharashtra 400 081, India.

Kastmed, määrded, marinaadid / Maarika Makarova

Index Scriptorium Estoniae

Makarova, Marika

2012-01-01

Toidule maitset lisavatest kastmetest, määretest, võietest, pastadest ja marinaadidest: grillkaste, guacamole, karripasta, ketšup,majonees, marinaad, misopasta, mädarõigas, pesto, sinep, sojakaste, tomatipüree, tomatipasta, tomatikaste, tzatziki, vasabi, vinegrett, äädikas

Medier og digital kultur

DEFF Research Database (Denmark)

Christiansen, René Boyer; Hestbech, Astrid Margrethe; Jørnø, Rasmus Leth Vergmann

ser en film eller er til en koncert. Børn og unge bliver ikke længere betragtet som novicer, men mere som forbrugere og kunder, der kræver at blive engageret og underholdt. Også i pædagogisk praksis må man derfor tage højde for, at børn, unge og brugere generelt kommer med nye forventninger og...... målbeskrivelser og krav til metodevalget, og der findes nu et modul, der indholdsmæssigt fokuserer på netop medier og digital kultur. Der er derfor behov for et samlet værk, der fagligt funderet diskuterer den nyeste viden om medier i pædagogisk praksis ud fra kravene om fokuseret og reflekteret arbejde med mål...

Planning and Designing Effective Defence and Related Information Services: Conference Proceedings of the Technical Information Panel Specialists’ Meeting Held in Ankara, Turkey on 10-11 September 1986.

Science.gov (United States)

1987-04-01

Is Defense, en alant au-doll de ce qua peut apporter un simple repertoire, commae celul du DTIC aux Etats-Unis (5). ii counvient donc de dhvelopper...en consultation mais devront etre exclus du prit. Maits touts laide qua h’on apportersa Al’utilisaeur, celul -ci perdra besucoup do tampa I cee...mains quoun systme do guichat ivolui. come celul dont il a iti question plus haut, soit jug& prifirable. 8-5 2.3. Sources primaires. Touts information

Tõtt-öelda : suvistest ehtekunstisündmustest / Kadri Mälk

Index Scriptorium Estoniae

Mälk, Kadri, 1958-

2003-01-01

Kaasaegse ehtekunsti suursündmus "Ars Ornata Europeana" Zürichis, juhtmotiiviks "Tõelus". Ettekannetest, Bernhard Schobingeri (sünd. 1946) retrospektiivnäitusest. Soomes Lappenrannas üritusel "Koru 1" osalesid Eestist oma töödega Ketli Tiitsar, Villu Plink, Mari ja Adolfas Shaulys

JPRS Report, East Europe.

Science.gov (United States)

1988-05-10

the law on demonopolizing, Igloopol has grabbed the meat market in our voivodship, leaving our butchers frozen goods, leftovers without shoulders... poultry meat products, so-called health foods permitted for export to EWG [European Common Mar- ket] countries. As evident, the regulations will

Effects of knee and ankle muscle fatigue on postural control in the unipedal stance.

Science.gov (United States)

Bizid, Riadh; Margnes, Eric; François, Yrieix; Jully, Jean Louis; Gonzalez, Gerard; Dupui, Philippe; Paillard, Thierry

2009-06-01

The aim of this study was to compare the effects of acute muscle fatigue of the ankle and knee musculature on postural control by immediate measures after performing fatiguing tasks (POST condition). One group of subjects (n = 8) performed a fatiguing task by voluntary contractions of the triceps surae (group TRI) and the other (n = 9) performed a fatiguing task by voluntary contractions of the quadriceps femoris (group QUA). Each muscle group was exercised until the loss of maximal voluntary contraction torque reached 50% (isokinetic dynamometer). Posture was assessed by measuring the centre of foot pressure (COP) with a force platform during a test of unipedal quiet standing posture with eyes closed. Initially (in PRE condition), the mean COP velocity was not significantly different between group TRI and group QUA. In POST condition, the mean COP velocity increased more in group QUA than in group TRI. The postural control was more impaired by knee muscle fatigue than by ankle muscle fatigue.

Space odysseys

DEFF Research Database (Denmark)

Antologi om unge danske arkitekter og designere. Udgivet som Arkitektur DK 5/2006 og som selvstændig publikation. Den indledende artikel er af arkitekturteoretisk karakter, de øvrige formidlende.   ...

Uretritis masculina gonocócica y no gonocócica Papel del laboratorio clínico en su diagnóstico microbiológico

Directory of Open Access Journals (Sweden)

Federico Díaz Gonzáles

1982-12-01

Full Text Available Se presenta la experiencia de 8 años en el diagnóstlco de laboratorio de la uretritis masculina en la práctica privada; en 1.567 pacientes que tenían evidencias clínicas y de laboratorio de la enfermedad , se halló un franco predominlo de la forma no gonocócica (81,0%. El examen directo con coloración de Gram de la secreción uretral o de la primera porcelón de orina matinal fue de gran valor diagnóstico tanto en la uretritis gonocóclca (UG como en le no gonocócica (UNG; la mayoría de los pacientes con UG tuvieron abundante secreción: lo contrario ocurrió con los de UNG; solo en estos se hallaron secreciones acuosas o mucoides y fueron comunes las modalidades mixtas. Se hace énfasis en la necesidad de disponer de datos nacionales sobre la frecuencia relativa de la UNG y la UG, así como de cultivos para Chlamydia y Ureaplasma con fines de investigación. El laboratorio clínico, mediante le coloración de Gram, puede hacer le distinción entre las dos formas de uretritis con prontitud, sencillez, economía y alto grado de confiabilidad.

Studies in Intelligence. Volume 57, Number 2 (June 2013)

Science.gov (United States)

2013-06-01

The goods they steal are usually sold to black mar- ket operators. The Edelweiss insig- nia is seen frequently in Germany, and it has become...and Execute Intelligence Collection in Complex Environments by Wayne Michael Hall and Gary Citrenbaum. (Praeger) 505 pp., endnotes, bibliography

QuaIity control of medicaI imaging

International Nuclear Information System (INIS)

Choi, Joon Il; Na, Dong Gyu; Lee, Jae Young; Kim, Hak Hee; Shin, Yong Moon; Ahn, Kook Jin

2004-01-01

Medical imaging is the one of the most important diagnostic tools of modern medical science and quality control of the medical imaging is already systemized in the advanced countries. However, in Korea, quality control of medical imaging has not been properly performed until now and low quality examinations have been done without any regulation. The Korean Radiological Society, as society of supervision of medical imaging, has emphasized the importance of quality control and in 2003, the law for the quality control of medical imaging was made. In conformity of the law, the regulation of the quality control of medical imaging will commence, but this is just the beginning and there are still many tasks left for settling down and expanding the range of the quality control of the medical imaging. We reviewed the history of the quality control of medical imaging in Korea and explained the particulars of mammography, fluoroscopy, computed tomography and magnetic resonance imaging. We also looked into future prospect and tasks of the quality control of medical imaging

ENVIRONMENTAL EDUCATION: A SINE-QUA-NON FOR ...

African Journals Online (AJOL)

JONATHAN

verse ranging from sea surge and flooding, melting of ice caps with potential ... level has grown from under 15,000 in 1970 to approximately 1.2 million today. Moreover ... (2004) state a rise in environmental awareness from the 1970s due to increased ..... (Doctoral thesis, University of Central Florida, Orlando, Florida, USA).

ENVIRONMENTAL EDUCATION: A SINE-QUA-NON FOR ...

African Journals Online (AJOL)

JONATHAN

embeddedness on formation of specific attitudes and behavioral intentions. Personality and. Social Psychology Bulletin, 22(8), 845-861. Purwanto, H. (1999). Human Behavior Based For Nursing. Jakarta: EGC. Robinson, J. O. (2013). Environmental Education and Sustainable Development in Nigeria: Breaking the missing ...

Young people without qualifications

DEFF Research Database (Denmark)

Rasmussen, Preben Horsholt

1999-01-01

Rapporten er et bidrag til en beskrivelse af hvordan uddannelses- og arbejdsmarkedspolitikken påvirker unge uden formelle kvalifikationer i fem europæiske lande : Belgien, Danmark, Cypern, Finland og Grækenland....

A quasi-linear gyrokinetic transport model for tokamak plasmas

International Nuclear Information System (INIS)

Casati, A.

2009-10-01

After a presentation of some basics around nuclear fusion, this research thesis introduces the framework of the tokamak strategy to deal with confinement, hence the main plasma instabilities which are responsible for turbulent transport of energy and matter in such a system. The author also briefly introduces the two principal plasma representations, the fluid and the kinetic ones. He explains why the gyro-kinetic approach has been preferred. A tokamak relevant case is presented in order to highlight the relevance of a correct accounting of the kinetic wave-particle resonance. He discusses the issue of the quasi-linear response. Firstly, the derivation of the model, called QuaLiKiz, and its underlying hypotheses to get the energy and the particle turbulent flux are presented. Secondly, the validity of the quasi-linear response is verified against the nonlinear gyro-kinetic simulations. The saturation model that is assumed in QuaLiKiz, is presented and discussed. Then, the author qualifies the global outcomes of QuaLiKiz. Both the quasi-linear energy and the particle flux are compared to the expectations from the nonlinear simulations, across a wide scan of tokamak relevant parameters. Therefore, the coupling of QuaLiKiz within the integrated transport solver CRONOS is presented: this procedure allows the time-dependent transport problem to be solved, hence the direct application of the model to the experiment. The first preliminary results regarding the experimental analysis are finally discussed

Verfahren zur Hydroformylierung, Liganden mit von Bisphenol A abgeleiteter Struktur und Katalysator umfassend einen Komplex dieser Liganden

NARCIS (Netherlands)

2002-01-01

Die vorliegende Erfindung betrifft ein Verfahren zur Hydroformylierung ethylenisch ungesättigter Verbindungen, wobei man als Hydroformylierungskatalysator wenigstens einen Komplex eines Metalss der VIII. Nebengruppe mit wenigstens einer phosphorhaltigen Verbindung als Liganden einsetzt, wobei diese

Fra STU-praktik til job

DEFF Research Database (Denmark)

Rasmussen, Kim

Rapporten består af 4 dele: 1.del - Metode, tilgang og baggrundsviden 2.del - Samarbejde mellem Glad Fagskole og virksomheder 3.del - Erfaringer og oplevelser med praktik 4.del - De unge - elevernes / praktikanternes oplevelser...

New Waves in Philosophy of Science

DEFF Research Database (Denmark)

Busch, Jacob

Bogen er et udstillingsvindue for de bedste unge forskere inden for deres felt. Hver især bidrager med hvad de mener bliver de mest centrale froskningstemaer der kommer til at definere disciplinen videnskabsfilosofi fremover....

Nitroxide-mediated controlled radical polymerisation: towards control of molar mass Controlled Radical Polymerisation

NARCIS (Netherlands)

Bon, S.A.F.; Bergman, F.A.C.; Es, van J.J.G.S.; Klumperman, B.; German, A.L.; Matyjaszewski, K.

1998-01-01

The mechanism of the TEMPO-mediated controlled radical polymerization of styrene in bulk is discussed. It is shown that the isotropic correlation time (tc) of a nitroxide can be used as a measure of the diffusive rate coefficient of trapping (ketD). A general empirical relationship for the density

Linking Polymer Dynamics to Melt Processing

Indian Academy of Sciences (India)

Ashish Lele

Linking Polymer Dynamics to Melt Processing. Ashish Lele. NaUonal Chemical Laboratory, Pune ak.lele@ncl.res.in www.cfpegroup.net. Mid-‐Year MeeUng July 2-‐3, 2010. Indian Academy of Sciences, Bangalore ...

In vitro antifungal susceptibility testing of Scopulariopsis brevicaulis strains using agar diffusion method.

Science.gov (United States)

Skóra, Magdalena; Macura, Anna B

2011-01-01

The genus Scopulariopsis is a common soil saprotroph and has been isolated from air, organic waste and also from plant, animal and human tissues. Scopulariopsis has mainly been associated in humans with superficial mycoses, but it has also been described as the cause of subcutaneous and invasive infections. The most common aetiological agent of infections in humans is Scopulariopsis brevicaulis. This species has been reported to be resistant in vitro to broad-spectrum antifungal agents available today. The aim of the study was to establish in vitro antifungal susceptibility of 35 S. brevicaulis strains against amphotericin B (AMB), flucytosine (FC), caspofungin (CAS), terbinafine (TER), ciclopirox (CIC), voriconazole (VOR), clotrimazole (CTR), miconazole (MCZ), econazole (ECO), ketoconazole (KET), itraconazole (ITR), and fluconazole (FLU). Antifungal susceptibility tests were evaluated by an agar diffusion method (Neo-Sensitabs, Rosco, Denmark). AMB, FC, CAS, ITR and FLU showed no antifungal activity against S. brevicaulis. TER, CIC, CTR, KET, VOR, ECO, and MCZ revealed inhibitory activity for S. brevicaulis, but it varied for each of the drugs. The best antifungal effect was observed for TER and CIC. All isolates had large inhibition zones for TER and CIC. CTR was also inhibitory for all tested S. brevicaulis isolates, but the diameters of inhibition zones were smaller than for TER and CIC. Nearly 89% isolates showed inhibition zones for KET and the mean diameter of the inhibition zone was comparable to CTR. The least antifungal activity exhibited VQR, ECO and MCZ. Because of the multiresistance of S. brevicaulis, infections due to this species may not respond to particular antifungal treatment and other therapeutic approaches should be considered, e.g., combined therapy and/or surgery.

Evaluation of injectable anaesthesia with five medetomidine-midazolam based combinations in Egyptian fruit bats ( Rousettus aegyptiacus).

Science.gov (United States)

Tuval, Avishag; Las, Liora; Shilo-Benjamini, Yael

2018-01-01

Egyptian fruit bats are increasingly used as model animals in neuroscience research. Our aim was to characterize suitable injectable anaesthesia for this species, possibly replacing inhalant anaesthesia, thus minimizing occupational health hazards. Eight bats were randomly assigned by a crossover design for subcutaneously administered combinations of medetomidine-midazolam with: saline (MM-Sal), ketamine (MM-Ket), fentanyl (MM-Fen), morphine (MM-Mor), or butorphanol (MM-But). The anaesthetic depth and vital signs were monitored at baseline and every 10 min until bats recovered. If after 180 min the bats did not recover, atipamezole was administered. Mean induction times were 7-11.5 min with all combinations. Twitching during induction was common. All combinations produced anaesthesia, with significantly decreased heart rate (from 400 to 200 bpm) and respiratory rate (from 120-140 to 36-65 rpm). Arrhythmia and irregular breathing patterns occurred. MM-Fen, MM-Mor, and MM-But depressed respiration significantly more than MM-Sal. Time to first movement with MM-Ket and MM-But lasted significantly longer than with MM-Sal. Recovery time was significantly shorter in the MM-Sal (88 min) in comparison to all other treatments, and it was significantly longer in the MM-But (159 min), with atipamezole administered to four of the eight bats. In conclusion, all five anaesthetic protocols are suitable for Egyptian fruit bats; MM-Ket produces long anaesthesia and minimal respiratory depression, but cannot be antagonized completely. MM-Fen, MM-Mor, and MM-But depress respiration, but are known to produce good analgesia, and can be fully antagonized. Administration of atipamezole following the use of MM-But in Egyptian fruit bats is recommended.

Udviklingen i unges alkohol- og stofbrug

DEFF Research Database (Denmark)

Østergaard, Stine Vernstrøm; Østergaard, Jeanette

2018-01-01

/26- års alderen ryger de typisk ikke længere hash. En anden gruppe (16%) debuterer tidligere og fortsætter med et hashbrug i 18/19-års alderen, mens de i 25/26-års alderen har meget varierende forbrugsmønstre. Den tredje gruppe (15%) starter også relativt tidligt men viser en gradvis maturing out, mens...... den fjerde lille gruppe (5%) både starter tidligt (14 år i gennemsnit) og fortsætter på relativt høje brugsniveauer både i 18/19-års alderen og i midt-20erne. De selvrapporterede negative konsekvenser af hashbrug er store i den mest hasherfarne gruppe, og mange siger, at de ønsker at skære ned og...

Danske ungdomsfilm - i de unges smag?

OpenAIRE

Mbinda, Jeppe; Lehmann, Tobias

2015-01-01

This master thesis is centered on the relationship and understanding that young Danes between 18-25 years have on Danish youth-films. Our interest in this field was evoked by the fact that it has been difficult to generate the expected ticket sales for youth films and that the genre is in a commercial crisis according to established research. We wanted to examine whether this was due to a communicative and strategic problems and/or due to the content of the genre? In order to identify and und...

Åben og Rolig for Unge

DEFF Research Database (Denmark)

Westphael, Gitte; Krogh, Søren Christian; Jensen, Christian Gaden

-14 deltagere) i samarbejde mellem Rigshospitalet og Herbert Bensons forskningsgruppe ved Harvard University (Jensen et al., 2015). Kurset afholdes af to psykologuddannede, certificerede instruktører og baseres på den biopsykosociale sundhedsmodel og sammensatte metoder, herunder meditation, kognitive øvelser...

[The life of Choe Ung-sok: with a focus on his design for and role in the health care system immediately after the liberation].

Science.gov (United States)

Shin, Young-Joen; Kim, Jinhyouk

2014-12-01

Born in Pyongyang in 1914, Choe Ung-sok was a physician who lived through the Japanese colonial era (1910-1945), rule by the United States Army Military Government in Korea (USAMGIK; 1945-1948), and national division (1948). Influenced by socialism and social hygiene/social medicine during his studies in Japan, he played the role of representing the socialist camp in the discussions related to the construction of a heath care system immediately following the Liberation (1945). His key arguments were: first, the nationalization of the medical system and the implementation of nationwide programs to eradicate diseases; second, the provision of free medical services through the expansion of social insurance; third, the reeducation of the medical personnel; fourth, the provision of social sciences education to the medical personnel and the reorganization of medicine into preventive medicine; fifth, the nationalization of pharmaceutics; sixth, the laborers' establishment of autonomous medical organs (affordable clinics, medical consumers' unions through cooperatives); and seventh, the reduction of work hours to 6-8 hours, technical improvement, respite from research, and guarantee of economic life for the medical personnel. Influenced by the medical systems of the Soviet Union and Japan, such arguments stood in opposition to the right wing's plan for the construction of a relatively passive health care system at the time but, in the end, failed to be realized in southern part of Korea under the USAMGIK. Subsequently, he defected to northern part of Korea and came to participate in the task of constructing North Korea's health care system. Choe's life and design for a health care system provide examples through which one can confirm the nature of social hygiene/social medicine both during the Japanese colonial era and before and after the Liberation and the contents of the design related to a health care system as held by the socialist faction. In addition, they show that

Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Directory of Open Access Journals (Sweden)

Leah M Prentice

Full Text Available Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the industry standard. Therefore clinical molecular laboratories must be able to work with formalin fixed, paraffin embedded (FFPE material. This study examines the effects of pre-analytic variables introduced by routine pathology processing on specimens used for clinical reports produced by next-generation sequencing technology. Tissue resected from three colorectal cancer patients was subjected to 2, 15, 24, and 48 hour fixation times in neutral buffered formalin. DNA was extracted from all tissues twice, once with uracil-N-glycosylase (UNG treatment to counter deamination effects, and once without. Of note, deamination events at methylated cytosine, as found at CpG sites, remains unaffected by UNG. After extraction a two-step PCR targeted sequencing method was performed using the Illumina MiSeq and the data was analyzed via a custom-built bioinformatics pipeline, including filtration of reads with mapping quality T/A mutations that is not represented in DNA treated with UNG. This suggests these errors may be due to deamination events triggered by a longer fixation time. However the allelic frequency of these events remained below the limit of detection for reportable mutations in this assay (<2%. We do however recommend that suspected intratumoral heterogeneity events be verified by re-sequencing the same FFPE block.

Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases: Poxvirus Uracil-DNA Glycosylase

Energy Technology Data Exchange (ETDEWEB)

Schormann, Norbert [Department of Medicine, University of Alabama at Birmingham, Birmingham Alabama 35294; Zhukovskaya, Natalia [Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104; Bedwell, Gregory [Department of Microbiology, University of Alabama at Birmingham, Birmingham Alabama 35294; Nuth, Manunya [Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104; Gillilan, Richard [MacCHESS (Macromolecular Diffraction Facility at CHESS) Cornell University, Ithaca New York 14853; Prevelige, Peter E. [Department of Microbiology, University of Alabama at Birmingham, Birmingham Alabama 35294; Ricciardi, Robert P. [Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104; Abramson Cancer Center, School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104; Banerjee, Surajit [Department of Chemistry and Chemical Biology, Cornell University, and NE-CAT Argonne Illinois 60439; Chattopadhyay, Debasish [Department of Medicine, University of Alabama at Birmingham, Birmingham Alabama 35294

2016-11-02

We report that uracil-DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil-DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA. These enzymes feature conserved structural folds, active site residues and use common motifs for DNA binding, uracil recognition and catalysis. Within this family the enzymes of poxviruses are unique and most remarkable in terms of amino acid sequences, characteristic motifs and more importantly for their novel non-enzymatic function in DNA replication. UNG of vaccinia virus, also known as D4, is the most extensively characterized UNG of the poxvirus family. D4 forms an unusual heterodimeric processivity factor by attaching to a poxvirus-specific protein A20, which also binds to the DNA polymerase E9 and recruits other proteins necessary for replication. D4 is thus integrated in the DNA polymerase complex, and its DNA-binding and DNA scanning abilities couple DNA processivity and DNA base excision repair at the replication fork. In conclusion, the adaptations necessary for taking on the new function are reflected in the amino acid sequence and the three-dimensional structure of D4. We provide an overview of the current state of the knowledge on the structure-function relationship of D4.

Tilpasning med blinde makkere

DEFF Research Database (Denmark)

Braae, Ellen Marie

2015-01-01

Udstillingstitlen "Regner kommer" lyder både som et løfte og en trussel, men forholder sig pragmatisk til problematikken. Imidlertid snarere lukker end åbner udstillingen for de mange relevante diskussioner dette endnu unge felt adresserer....

Digitale medier

DEFF Research Database (Denmark)

Sørensen, Birgitte Holm; Levinsen, Karin

2013-01-01

internetbrugere. Ifølge EU-Kids Online (2011) er børn i Danmark og Sverige syv år, når de har deres internetdebut. En rapport fra Medierådet i Sverige, fra 2010, omfattende svenske børn, Småungar & Medier – Fakta om små barns användning och upplevelser av medier, viser, at debutalderen er endnu lavere, nemlig...... brug af sociale medier, så viser en undersøgelse fra Medierådet for Børn og Unge i Danmark, at mere end hvert fjerde barn på 9-10 år har en profil på internettet, og at Facebook er det mest foretrukne (Medierådet for Børn og Unge 2009). Børnene finder det med andre ord vigtigt at omsætte deres læse- og...

Etude hyperfrequence et ultrasonore des supraconducteurs organiques kappa-(ET)(2)X (X = copper(thiocyanogen), copper[N(CN)(2)]bromine)

Science.gov (United States)

Frikach, Kamal

2001-09-01

Dans ce travail je presente une etude de l'impedance de surface, ainsi que de l'attenuation et la variation de la vitesse ultrasonores dans les etats normal et supraconducteur sur les composes organiques k-(ET)2X (X = Cu(SCN) 2, Cu[N(CN)2]Br). A partir des mesures d'impedance de surface, les deux composantes sigma 1 et sigma2 de la conductivite complexe sont extraites en utilisant le modele de Drude. Ces mesures montrent que la symetrie du parametre d'ordre dans ces composes est differente de celle du cas BCS. Afin de comprendre le profil de sigma1 (T) nous avons etudie les fluctuations supraconductrices a partir de la paraconductivite sigma'( T). Cette etude est rendue possible grace a la structure quasi-2D des composes k-(ET)2X dans lesquelles les fluctuations supraconductrices sont fortes. Ces dernieres sont observees sur deux decades de temperatures dans le Cu(SCN)2. L'application du modele de Aslamazov-Larkin 2D et 3D montre la possibilite du passage du regime 2D a haute temperature au regime 3D au voisinage de Tc. En se basant sur ce resultat, nous avons calcule la paraconductivite en utilisant une approche a l'ordre d'une boucle a partir du modele de Lawrence-Doniach. En tenant compte de la correction par la self energie dans la limite dynamique (17 GHz), l'ajustement de la paraconductivite calculee est en bon accord avec les donnees experimentales. Le couplage interplan obtenu est compatible avec le caractere quasi-2D des composes organiques. Le temps de relaxation des quasi-particules dans l'etat supraconducteur est ensuite extrait pour la premiere fois dans ces composes dont le comportement en fonction de la temperature est compatible avec la presence des noeuds dans le gap. Dans l'etat normal, la variation de la vitesse ultrasonore presente un comportement anormal caracterise par un fort ramollissement a T = 38 K et 50 K dans k-(ET) 2Cu(SCN)2 et k-(ET)2Cu[N(CN) 2]Br respectivement dont l'amplitude est independante du champ magnetique jusqu'a H = Hc 2

NanoSTAIR: A new strategic proposal to impulse standardization in nanotechnology research

NARCIS (Netherlands)

Ipiña, J.M.L. de; Salvi, O.; Hazebrouck, B.; Jovanovic, A.; Carre, F.; Saamanen, A.; Brouwer, D.; Schmitt, M.; Martin, S.

2015-01-01

Nanotechnology is considered one of the key technologies of the 21st century within Europe and a Key-Enabling Technology (KET) by Horizon 2020. Standardization has been identified in H2020 as one of the innovation-support measures by bridging the gap between research and the market, and helping the

Möödus vaikselt / Tiina Käesel

Index Scriptorium Estoniae

Käesel, Tiina, 1943-

2001-01-01

Tallinna rakenduskunsti triennaalist 2000 "Omand" Tarbekunstimuuseumis. Kontseptsioon-kujundus: Ketli Tiitsar, Kaire Rannik, Berit Teeäär, Kristi Paap (F.F.F.F.). Paremaid esinejaid. Peaauhind - Eija Mustonen (Soome), auhinnad - Audrius Janushonis (Leedu), Claus Domine Hansen (Taani), Tarbekunstimuuseumi ostuauhind - Aigi Orav, grupi F.F.F.F. auhind - Monika Järg

Erken Tabgaç (T’o-pa Tarihinin Ana Hatları (Wei Shu’nun İlk Bölümüne Göre Outlines of Early Tabgach (T’o-pa History (According to First Chapter of Wei Shu

Directory of Open Access Journals (Sweden)

Kürşat YILDIRIM

2012-09-01

Full Text Available The History of Tabgach Turks who recorded in Chinese sources under the name of T’o-pa is little known. Tabgachs dominated on Northern China in 386 AD, governed China for nearly two centuries and finally disappeared from the stage of history by becoming Chinese people. Some scholars investigated this period of Tabgachs. However, their emergence to stage of history and their history until 386 AD are little studied. Tabgachs begun to take place in the Chinese sources in years about 160-170. They strengthened their state formation anddominated on all of their neighbors in the period of Li-wei (220-277.They established Tai State under the reign of I-lu in 314 and this statelasted until 376. Especially in the reign of Shih-i-chien (338-376,Tabgach State strengthened and extended its domination from Liaoningin east to Ferghana in west. Largest state formation of Tabgachs isNorthern Wei State that dominated all of China and later becameChinese. Our article aims to study this period lasted until 386 based onfirst chapter of Wei Shu that is official dynastic history of TabgachDynasty. Besides this, it is applied to main sources as Shih Chi, HanShu, Hou Han Shu, San Kuo Chih, Chin Shu, T’ai P’ing Yü Lan, Ts’e FuYüan Kuei, T’ung Chih, Wen Hsien T’ung Kao, Tzu Chih T’ung Chien,T’ung Tien and research studies. We hope to contribute to later studieson political history, linguistics, cultural history about Tabgachs withour study in General Turkic History. Çin kaynaklarında T’o-pa adı altında kaydedilen Tabgaç Türklerinin tarihleri az bilinmektedir. Tabgaçlar M.S. 386 yılında Kuzey Çin’e hâkim oldular, yaklaşık iki yüzyıl Çin’i idâre ettiler ve nihayetinde Çinlileşip tarih sahnesinden çekildiler. Bazı âlimler Tabgaçların bu devrini incelemişlerdir. Bununla beraber Tabgaçların tarih sahnesine çıkışları ve 386 yılına kadar olan tarihleri pek çalışılmamıştır. Tabgaçlar 160-170 yıllarında �

Everyday life in focus in residential child care

DEFF Research Database (Denmark)

Nielsen, Helle Schjellerup

2010-01-01

Artiklen beskriver hvad nyere dansk forskning peger på som døgninstitutionernes akilleshæl og hvordan fokus er ved at flytte i retning af udsatte børn og unges venskabsdannelse, skolegang og fritidsliv uden for døgninstitutionen....

Sat uden for døren?

DEFF Research Database (Denmark)

Ryom, Knud Eske

2014-01-01

KOMMENTAR. Kan gruppecoaching af udsatte drenge på Nørrebro fungere som en redningsplanke til en ’fortabt’ gruppe? Ph.d.-studerende Knud Ryom fortæller her om, hvad gruppecoaching kan, og hvorfor han tilbyder det til udsatte unge i sit forskningsprojekt....

Aldersdiskrimination - Ageism. En trussel mod Healthy Ageing

DEFF Research Database (Denmark)

Lind, Johanne

2016-01-01

Samfundet og de professionelle har pligt til at beskytte individer, unge såvel som gamle. Aldersdiskrimination er et samfundsproblem, politisk, socialt og kulturelt. Denne artikel introducerer til begrebet alders-diskrimination og diskuterer holdningen til alder i forhold til ældres sundhed. Der ...

De måske kvalificerede

DEFF Research Database (Denmark)

Tireli, Üzeyir; Larsen, Vibe

2014-01-01

Kapitlet beskæftiger sig med ungdom og ungdomsuddannelse med udgangspunkt i den politiske beslutning fra 2010 om vurdering af uddannelsesparathed af unge i folkeskolens 9. og 10.klasse. Kapitlet indeholder ligeledes en diskussion af hvilke frasorteringer og marginaliseringer denne vurdering skaber....

Individual Drawings and Collective Representations

DEFF Research Database (Denmark)

Rothstein, Mikael

2008-01-01

En undersøgelse af hvordan forestillinger om døden, herunder selvmord, kommer til udtryk i unge indianeres tegninger, og hvordan såvel den historiske udvikling, deres sociale situation samt en række religiøse forestillinger spiller en rolle....

Kampen om Kinas medier: Fri presse eller socialistisk propaganda

DEFF Research Database (Denmark)

Dombernowsky, Laura Møller

2012-01-01

Mens unge kinesere sætter deres lid til, at kommercielle medier vil øge den journalistiske frihed, råber kritikere vagt i gevær. De frygter, at de socialistiske idealer ryger i svinget. ANALYSE af Laura Dombernowsky, Beijing, Kina...

Ungdomslitteratur former(er) sig

DEFF Research Database (Denmark)

Henkel, Ayoe Qvist

2016-01-01

Igennem en 'mediesensitiv' analyse af romanen "Akavet" af Ronnie Andersen (2014) og perspektivering til andre aktuelle romaner for og med unge undersøger artiklen, hvordan ungdomslitteratur udvikler sig i dialog med digitale og mediebaserede impulser, og hvilke konsekvenser for udsigelserne om...... ungdomsliv og ungdomslitteraturens æstetik og mulige egenart, denne udvikling har. Artiklen baserer sig på en materialitetstilgang særligt inspireret af N. Katherine Hayles, som ikke tidligere har fået opmærksomhed i læsninger af ungdomslitteratur eller i diskussioner af ungdomslitteraturens mulige egenart......, at ungdomslitteratur drejer sig om unges udviklingsproces fra barndom og til voksenhed og dermed skildrer en overgang præget af linearitet, modning og vækst. Artiklen konkluderer, at der er ungdomslitteratur, der realiseres på andre præmisser, og Akavet kan ses som eksponent for en bevægelse fra ungdomslitteratur som...

Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate

Directory of Open Access Journals (Sweden)

Xinxu Yuan

2018-06-01

Full Text Available Short chain fatty acids (SCFAs, a family of gut microbial metabolites, have been reported to promote preservation of endothelial function and thereby exert anti-atherosclerotic action. However, the precise mechanism mediating this protective action of SCFAs remains unknown. The present study investigated the effects of SCFAs (acetate, propionate and butyrate on the activation of Nod-like receptor pyrin domain 3 (Nlrp3 inflammasome in endothelial cells (ECs and associated carotid neointima formation. Using a partial ligated carotid artery (PLCA mouse model fed with the Western diet (WD, we found that butyrate significantly decreased Nlrp3 inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc+/+, which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc-/-. Nevertheless, both acetate and propionate markedly enhanced the formation and activation of the Nlrp3 inflammasome as well as carotid neointima formation in the carotid arteries with PLCA in Asc+/+, but not Asc-/- mice. In cultured ECs (EOMA cells, butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket or cholesterol crystals (CHC, while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes. Mechanistically, the inhibitory action of butyrate on the Nlrp3 inflammasome was attributed to a blockade of lipid raft redox signaling platforms to produce O2•- upon 7-Ket or CHC stimulations. These results indicate that SCFAs have differential effects on endothelial Nlrp3 inflammasome activation and associated carotid neointima formation. Keywords: Arterial endothelium, Short chain fatty acids, Inflammation, Neointima, Atherosclerosis

The new physician as unwitting quantum mechanic: is adapting Dirac's inference system best practice for personalized medicine, genomics, and proteomics?

Science.gov (United States)

Robson, Barry

2007-08-01

What is the Best Practice for automated inference in Medical Decision Support for personalized medicine? A known system already exists as Dirac's inference system from quantum mechanics (QM) using bra-kets and bras where A and B are states, events, or measurements representing, say, clinical and biomedical rules. Dirac's system should theoretically be the universal best practice for all inference, though QM is notorious as sometimes leading to bizarre conclusions that appear not to be applicable to the macroscopic world of everyday world human experience and medical practice. It is here argued that this apparent difficulty vanishes if QM is assigned one new multiplication function @, which conserves conditionality appropriately, making QM applicable to classical inference including a quantitative form of the predicate calculus. An alternative interpretation with the same consequences is if every i = radical-1 in Dirac's QM is replaced by h, an entity distinct from 1 and i and arguably a hidden root of 1 such that h2 = 1. With that exception, this paper is thus primarily a review of the application of Dirac's system, by application of linear algebra in the complex domain to help manipulate information about associations and ontology in complicated data. Any combined bra-ket can be shown to be composed only of the sum of QM-like bra and ket weights c(), times an exponential function of Fano's mutual information measure I(A; B) about the association between A and B, that is, an association rule from data mining. With the weights and Fano measure re-expressed as expectations on finite data using Riemann's Incomplete (i.e., Generalized) Zeta Functions, actual counts of observations for real world sparse data can be readily utilized. Finally, the paper compares identical character, distinguishability of states events or measurements, correlation, mutual information, and orthogonal character, important issues in data mining and biomedical analytics, as in QM.

Topiramate via NMDA, AMPA/kainate, GABAA and Alpha2 receptors and by modulation of CREB/BDNF and Akt/GSK3 signaling pathway exerts neuroprotective effects against methylphenidate-induced neurotoxicity in rats.

Science.gov (United States)

Motaghinejad, Majid; Motevalian, Manijeh; Fatima, Sulail; Beiranvand, Tabassom; Mozaffari, Shiva

2017-11-01

Chronic abuse of methylphenidate (MPH) often causes neuronal cell death. Topiramate (TPM) carries neuroprotective effects, but its exact mechanism of action remains unclear. In the present study, the role of various doses of TPM and its possible mechanisms, receptors and signaling pathways involved against MPH-induced hippocampal neurodegeneration were evaluated in vivo. Thus, domoic acid (DOM) was used as AMPA/kainate receptor agonist, bicuculline (BIC) as GABA A receptor antagonist, ketamine (KET) as NMDA receptor antagonist, yohimbine (YOH) as α 2 adrenergic receptor antagonist and haloperidol (HAL) was used as dopamine D 2 receptor antagonist. Open field test (OFT) was used to investigate the disturbances in motor activity. Hippocampal neurodegenerative parameters were evaluated. Protein expressions of CREB/BDNF and Akt/GSK3 signaling pathways were also evaluated. Cresyl violet staining was performed to show and confirm the changes in the shape of the cells. TPM (70 and 100 mg/kg) reduced MPH-induced rise in lipid peroxidation, oxidized form of glutathione (GSSG), IL-1β and TNF-α levels, Bax expression and motor activity disturbances. In addition, TPM treatment increased Bcl-2 expression, the level of reduced form of glutathione (GSH) and the levels and activities of superoxide dismutase, glutathione peroxidase and glutathione reductase enzymes. TPM also inhibited MPH-induced hippocampal degeneration. Pretreatment of animals with DOM, BIC, KET and YOH inhibited TPM-induced neuroprotection and increased oxidative stress, neuroinflammation, neuroapoptosis and neurodegeneration while reducing CREB, BDNF and Akt protein expressions. Also pretreatment with DOM, BIC, KET and YOH inhibited TPM-induced decreases in GSK3. It can be concluded that the mentioned receptors by modulation of CREB/BDNF and Akt/GSK3 pathways, are involved in neuroprotection of TPM against MPH-induced neurodegeneration.

Effects of muscle composition and architecture on specific strength in obese older women.

Science.gov (United States)

Rastelli, F; Capodaglio, P; Orgiu, S; Santovito, C; Caramenti, M; Cadioli, M; Falini, A; Rizzo, G; Lafortuna, C L

2015-10-01

What is the central question of this study? Do obesity-specific factors affect skeletal muscle performance in older individuals? What is the main finding and its importance? Older obese women have a larger quadriceps femoris size but develop lower tension per unit of skeletal muscle than their normal-weight counterparts. Muscle impairment and excess body mass are very common among older people. Given that the effect of obesity on strength production has scarcely been studied in older individuals, we analysed functional and structural characteristics of quadriceps femoris (QF) in obese (OB) and normal-weight (NW) older women with comparable habitual physical activity. In five OB (body mass index 36.8 ± 1.9 kg m(-2), age 72.4 ± 2.3 years) and six NW well-functioning older women (body mass index 24.3 ± 1.8 kg m(-2), age 72.7 ± 1.9 years), peak knee-extension torque (KET) was measured in isometric (90 deg knee flexion) and isokinetic conditions (240, 180, 120 and 60 deg s(-1)). Mid-thigh QF cross-sectional area (CSA) and muscle tissue fat content (MF%) were determined with magnetic resonance imaging (Dixon sequence). Muscle fascicle length and pennation angle (PA) were assessed with ultrasonography for each muscle belly of the QF (vastus lateralis, vastus intermedius, rectus femoris and vastus intermedius). Despite similar values of KET, CSA was 17.0% larger in OB than in NW women (P Muscle composition and architecture seem to be important determinants of KET/CSA in elderly women. In fact, owing to the effect of obesity overload, OB women have a larger QF size than NW women, but unfavourable muscle composition and architecture. The higher MF% and steeper PA observed in OB women are associated with reduced levels of muscle specific strength. © 2015 The Authors. Experimental Physiology © 2015 The Physiological Society.

Kolmemõõtmeline Eesti kunst Szentendre Kunstiveskis / Peeter Helme

Index Scriptorium Estoniae

Helme, Peeter, 1978-

2003-01-01

Eesti tarbekunsti näitus "Ülestähendused". Avamisel näidati Jaanus Orgusaare rõivaste, jalanõude ja peakatete kollektsiooni. Kuraatoriteks-kujundajateks rühmitus F.F.F.F. (Ketli Tiitsar, Kristi Paap, Kaire Rannik, Maria Valdma). Keldrisaalis slaidiprogramm eesti harrastuskunstnike loomingust. Péter-Pali galeriis Anu Raua põimevaipade näitus

Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia

International Nuclear Information System (INIS)

Bouder, T.G.; Huffman, L.J.; Hedge, G.A.

1988-01-01

In rats anesthetized with ketamine and pentobarbital (KET/PB), vasoactive intestinal peptide (VIP) increases vascular conductance (VC) in the salivary gland, pancreas, and thyroid gland, whereas no changes in VC are observed in a number of other organs. Because anesthesia may alter the responsiveness of physiological systems, we compared the effects of VIP on organ VC in conscious or anesthetized rats. Chronically catheterized rats were studied in the conscious state or 30 min after induction of anesthesia with KET/PB, isoflurane, or Inactin. Blood flows were measured by the reference sample version of the radioactive microsphere (MS) technique using two MS injections ( 141 Ce-MS/ 85 Sr-MS). Mean arterial blood pressure was monitored and used in the calculation of VC. Organ VCs were similar under basal conditions in conscious and anesthetized rats. VIP infusion caused systemic hypotension and increased VCs in the salivary gland, pancreas, and thyroid gland, and these responses were largely unaffected by anesthesia. These results indicate that the anesthetics used do not alter basal VC or the responsiveness of the vasculature to exogenous VIP

Illicit drugs and their metabolites in 36 rivers that drain into the Bohai Sea and north Yellow Sea, north China.

Science.gov (United States)

Wang, De-Gao; Zheng, Qiu-Da; Wang, Xiao-Ping; Du, Juan; Tian, Chong-Guo; Wang, Zhuang; Ge, Lin-Ke

2016-08-01

Illicit drugs and their metabolites have recently been recognized as an emerging group of contaminants due to their potential ecotoxicological impact in aquatic ecosystems. To date, information on the occurrence of these compounds in the aquatic environment of China remains limited. In this study, we collected surface water samples from 36 rivers in north China that discharge into the Bohai Sea and north Yellow Sea and measured the concentrations of amphetamine-like compounds, ketamines, cocainics, and opioids. The occurrence and spatial patterns of these substances show significant differences between the rivers and regions. Two designer drugs, methamphetamine (METH) and ketamine (KET), were the most abundant compounds detected in the entire set of samples (detection frequency of 92 and 69 %). The concentrations of METH and KET ranged from illicit drugs consumed in China. The high concentrations of these illicit drugs and their metabolites were found in areas that have a high population density. The riverine input of total illicit drugs into the Bohai Sea and north Yellow Sea was estimated to be in the range of 684 to 1160 kg per year.

Alkylation sensitivity screens reveal a conserved cross-species functionome

Science.gov (United States)

Svilar, David; Dyavaiah, Madhu; Brown, Ashley R.; Tang, Jiang-bo; Li, Jianfeng; McDonald, Peter R.; Shun, Tong Ying; Braganza, Andrea; Wang, Xiao-hong; Maniar, Salony; St Croix, Claudette M.; Lazo, John S.; Pollack, Ian F.; Begley, Thomas J.; Sobol, Robert W.

2013-01-01

To identify genes that contribute to chemotherapy resistance in glioblastoma, we conducted a synthetic lethal screen in a chemotherapy-resistant glioblastoma derived cell line with the clinical alkylator temozolomide (TMZ) and an siRNA library tailored towards “druggable” targets. Select DNA repair genes in the screen were validated independently, confirming the DNA glycosylases UNG and MYH as well as MPG to be involved in the response to high dose TMZ. The involvement of UNG and MYH is likely the result of a TMZ-induced burst of reactive oxygen species. We then compared the human TMZ sensitizing genes identified in our screen with those previously identified from alkylator screens conducted in E. coli and S. cerevisiae. The conserved biological processes across all three species composes an Alkylation Functionome that includes many novel proteins not previously thought to impact alkylator resistance. This high-throughput screen, validation and cross-species analysis was then followed by a mechanistic analysis of two essential nodes: base excision repair (BER) DNA glycosylases (UNG, human and mag1, S. cerevisiae) and protein modification systems, including UBE3B and ICMT in human cells or pby1, lip22, stp22 and aim22 in S. cerevisiae. The conserved processes of BER and protein modification were dual targeted and yielded additive sensitization to alkylators in S. cerevisiae. In contrast, dual targeting of BER and protein modification genes in human cells did not increase sensitivity, suggesting an epistatic relationship. Importantly, these studies provide potential new targets to overcome alkylating agent resistance. PMID:23038810

High-efficiency Gaussian key reconciliation in continuous variable quantum key distribution

Science.gov (United States)

Bai, ZengLiang; Wang, XuYang; Yang, ShenShen; Li, YongMin

2016-01-01

Efficient reconciliation is a crucial step in continuous variable quantum key distribution. The progressive-edge-growth (PEG) algorithm is an efficient method to construct relatively short block length low-density parity-check (LDPC) codes. The qua-sicyclic construction method can extend short block length codes and further eliminate the shortest cycle. In this paper, by combining the PEG algorithm and qua-si-cyclic construction method, we design long block length irregular LDPC codes with high error-correcting capacity. Based on these LDPC codes, we achieve high-efficiency Gaussian key reconciliation with slice recon-ciliation based on multilevel coding/multistage decoding with an efficiency of 93.7%.

DynaGuard: Armoring Canary-Based Protections against Brute-Force Attacks

Science.gov (United States)

2015-12-11

format of the canary check or a function’s prologue and epilogue. Finally, due to the small number of canary-protected frames that (on average) are...sje ng 462 .lib qua ntu m 464 .h2 64r ef 471 .om net pp 473 .as tar 483 .xa lan cbm k Apa che Ng inx Pos tgre SQ L SQ Lite My SQ L Sl ow do w n (n...k 456 .hm me r 458 .sje ng 462 .lib qua ntu m 464 .h2 64r ef 471 .om net pp 473 .as tar 483 .xa lan cbm k Apa che Ng inx

Cute and Cool in Contemporary Japanese Visual Arts

DEFF Research Database (Denmark)

Borggreen, Gunhild Ravn

2011-01-01

Med udgangspunkt i officiel japansk promovering af tre unge kvinder inden for modebranchen som kulturambassadører inden for "Japan Cool" diskuterer artiklen forskellige kulturelle aspekter af det japanske begreb kawaii (nuttet) som både brand for japansk kultureksport og som et kritisk subversivt...

SeaQuaKE: Sea-optimized Quantum Key Exchange

Science.gov (United States)

2015-01-01

spatial modes (e.g. orbital angular momentum), on the other hand, will not be considered here, due to the challenges that harsh atmospheric propagation...three smaller subsystems, including the pump source, time-bin multiplexer , polarization entanglement & pair generation elements. Also shown are some...quality f Time-bin/ polariz. analysis Hyper- entangled source Tx aperture ALICE Laser pump f f ff f f PBSf f MZI SPDs MZI PBS Time-Bin Entanglement

Ja kun sinä helluni (2/4, 3/4 F)

OpenAIRE

2011-01-01

Laulun sanat: Ja kun sinä helluni, meillen tuut, älä ketäkään tervehtele, aja vain hevoses tallin eteen äläkä ujostele! Ja kun sinä, helluni, meillen tuut, niin tule sinä illalla hiljaa! Tule sinä naapurin pellon poikki ja älä sinä polje viljaa!

Dictogloss or Dicto-Phrase: Which Works Better for Listening Comprehension?

Science.gov (United States)

Marashi, Hamid; Khaksar, Mojgan

2013-01-01

This research compared the effect of using dictogloss and dicto-phrase tasks on EFL learners' listening comprehension. To fulfill the purpose of the study, a piloted sample Key English Test (KET) was administered to a total number of 90 Iranian female teenage EFL learners at Kish Language School, Tehran, and then 60 were selected based on their…

Incentives for Recruiters

Science.gov (United States)

1992-09-01

promotions, with prizes for the kids: anything from football ti’kets to trips to Disneyland ." [Ref. 10:p. 68] Any publisher who wants a successful...such as a trip to Disneyland . The latter focuses more on providing an 29 incentive to the carrier to get a certain number of new customers in a short

Housing's impact on wood products sales

Science.gov (United States)

Matt Bumgardner; Urs Buehlmann; Karen. Koenig

2017-01-01

What are the market conditions for woodworkers involved in construction-based sectors and what investments are planned to improve capabilities in the current business environment? For a fifth straight year, construction-based mar­kets continued their growth trends in 2016, as U.S. spending on single family housing, multi-family housing, and nonresidential construction...

Hope and Resilience - Suicide Prevention in the Arctic

DEFF Research Database (Denmark)

Pedersen, Cecilia Petrine; Larsen, Christina Viskum Lytken

Konference rapport fra seminaret "Hope and Resilience in Suicide Prevention", der blev afholdt i Nuuk, november 2009. Rapporten beskriver baggrunden for seminaret og indeholder referater af oplæg fra seminaret givet af forskere, praktikere og unge. Et væsentligt indhold i rapporten er desuden...

The world is moving

DEFF Research Database (Denmark)

Thorning, Thomas Harpøth

2007-01-01

Verden bevæger sig, og skolen må gøre det samme. Animation breder sig globalt set i cyberspacespil og film, som børn og unge er storforbrugere af. Skolen bør give eleverne en grundlæggende indsigt i, hvordan det skabes....

The evolutionary strata of DARPP-32 tail implicates hierarchical ...

Indian Academy of Sciences (India)

The evolutionary strata of DARPP-32 tail implicates hierarchical functional expansion in higher vertebrates. CHOONG YONG UNG and TEOW CHONG TEOH. Supplementary data 1. Protein sequences of PPP1R1 family from 39 vertebrate species in FASTA format. Supplementary data 2. Multiple sequence alignment results ...

The Paradox of Schooling

DEFF Research Database (Denmark)

Valentin, Karen

En antropologisk ph.d. afhandling baseret på længerevarende feltarbejde blandt urbane squatter-familer i Kathmandu. I afhandlingen diskuteres dels hvordan forskellige former for social differentiering forhandles i forhold til erfaringer af og forventninger til skoling, dels hvordan børn og unge e...

Sex er kommet for at blive

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Lind, Unni

2012-01-01

Redaktionel indledning (som fokusansvarlig) om fokus på seksualitet i Vera nr. 60. Tidsskriftet satte i dette nr. fokus på viden om børn, unges og udvik,lingshæmmedes seksualitet og de udfordringer, det kan stille det pædagogiske arbejde over for....

Adfærdsændringer og omkostninger ved FFT

DEFF Research Database (Denmark)

Scavenius Sonne-Schmidt, Christoffer; Lindberg, Malene Rudolf

2018-01-01

Implementering af en ny indsats indebærer en afvejning af gevinster og omkostninger. Denne sammenfatning beskriver unges og voksnes udvikling henover et indsatsforløb med FFT og vurderer omkostningerne ved at implementere og drive et FFT-team. Dette er sammenfatning del I. Her opsummeres resultat...

Ungdomsselvmord og moderniseringsproblemer blandt inuit i Grønland

DEFF Research Database (Denmark)

Thorslund, Jørgen

Undersøgelse fra Det grønlandske Forebyggelsesråds projekt vedrørende ungdomsselvmord, der ud fra kulturelle, sociale og psykologiske problemaspekter belyser årsagerne til selvmord blandt unge grønlændere og bringer forslag til forebyggelsesinitiativer, [...] der kan mindske antallet af selvmord....

Dilemmaer i de nordiske landes ungdomsuddannelser

DEFF Research Database (Denmark)

Jørgensen, Christian Helms

2013-01-01

De nordiske lande er fælles om at ville sikre alle unge en uddannelse – men vi løser opgaven på helt forskellig vis. Lektor Christian Helms Jørgensen giver et bud på, hvad de nordiske lande kan lære af hinanden....

Kemi 2.0

DEFF Research Database (Denmark)

Johannesson, Anne Boie

2014-01-01

temaer, hvor eleverne laver deres eget didaktiske design indenfor rammerne af lærerens didaktiske design. Fokus i gruppearbejdet er udarbejdelse af web 2.0-produkter og meningsforhandling. Lærerens rolle er at hjælpe når der er behov for det, fremfor at lave almindelig tavleundervisning. Kemi 2.0 ligger......I dette projekt undersøges det hvordan kemi C på stx kan gøres it-baseret og almendannende. Løsningen er elevaktiverende og temabaseret undervisning samt fokus på kompetencer, fremfor kun på kvalifikationer. Det didaktiske design af kemi 2.0 er baseret på socialkonstruktivismen og inspireret af...... Dewey, Kolb, Illeris, Wenger og Luhmann. De unge karakteriseres med udgangspunkt i forskellige generationsbeskrivelser, og principper for didaktik 2.0, der imødekommer de unges forventninger og måder at lære på, skitseres. Principperne i kemi 2.0 er længerevarende gruppearbejde indenfor vedkommende...

The pathway to an ADHD diagnosis

DEFF Research Database (Denmark)

Bang Madsen, Kathrine

Baggrund: Attention Deficit Hyperactivity Disorder (ADHD) er en adfærdsmæssig lidelse, som er karakteriseret ved uopmærksomhed, hyperaktivitet og impulsivitet. ADHD er en af de mest almindelige børnepsykiatriske lidelser med en prævalens på 3-5% blandt børn og unge. I de seneste årtier har vi set...... en stigning i forekomsten af børn og unge med en ADHD-diagnose. En stor geografisk spredning i forekomsten af diagnosen giver dog anledning til at undersøge, hvad der påvirker diagnosticeringen af ADHD. Formål: Det overordnede formål med denne ph.d-afhandling var at undersøge betydningen af...... strukturelle, samfundsmæssige, familiemæssige og individuelle faktorer for ADHD-diagnosen. Metode: De anvendte datakilder var nationale sundhedsregistre og den danske nationale fødselskohorte, Bedre Sundhed for Mor og Barn (BSMB). Følgende blev undersøgt ved hjælp af befolkningsbaserede observationelle studier...

Sociale indsatser til mennesker med ADHD

DEFF Research Database (Denmark)

Bengtsson, Steen; Alim, Winnie; Holmskov, Henriette

Igennem de seneste år har flere og flere fået stillet diagnosen ADHD, som er en adfærdsmæssig forstyrrelse. Mennesker med ADHD har meget forskelligt støttebehov, og rapportens formål er at skabe overblik over de eksisterende sociale indsatser og tilbud til børn, unge og voksne med ADHD. Langt de...... ansvar for sociale end for terapeutiske tilbud i forhold til gruppen med ADHD. Mange voksne med ADHD beskriver, at det kræver mange ressourcer at få den fornødne støtte fra kommunen, mens forældre til børn med ADHD oplever det som nemmere at få adgang til de rette støttetilbud. Men begge grupper møder...... mange udfordringer som fx manglende koordinering og hyppige sagsbehandlerskift. Rapporten er udarbejdet i tilknytning til Servicestyrelsens projekt ’Ny og forstærket indsats til børn, unge og voksne med ADHD’ og er finansieret af Socialministeriet....

Diagnosis of depressed young people-criterion validity of WHO-5 and HSCL-6 in Denmark and Norway

DEFF Research Database (Denmark)

Christensen, Kaj Sparle; Haugen, Wenche; Sirpal, Manjit K

2015-01-01

Ifølge WHO bidrager depression væsentligt til den globale sygdomsbyrde. Depressioner hos voksne har ofte deres debut i ungdomsårene. Korte, pålidelige depressionsskalaer er fremmende for tidlig identifikation af depressioner. Formålet med denne undersøgelse var at validere WHO-5 og HSCL-6...... spørgeskemaer til opsporing af depression blandt unge. Projektet blev gennemført som et multicenter-studie i almen praksis i Danmark og Norge. I alt 294 unge i alderen 14-16 år deltog ved at besvare et papir- eller webbaseret spørgeskema og gennemførte efterfølgende et Composite International Diagnostic...... Interview (CIDI), som blev brugt som diagnostisk standard. Depression blev i undersøgelsen defineret ud fra ICD-10 kriterier. Kriterievaliditeten blev undersøgt i form af Receiver Operating Curve analyser og cut-offs for depression blev beregnet ved anvendelse af Youden-indekset. Forekomsten af depression...

Vapour pressures of uranium and uranium nitride over UN(s)

International Nuclear Information System (INIS)

Venugopal, V.; Kulkarni, S.G.; Subbanna, C.S.; Sood, D.D.

1992-01-01

The vaporization of uranium mononitride is investigated in the temperature range 1757 to 2400 K by Knudsen effusion cell mass spectrometry. The vaporization occurs incongruently by the preferential loss of nitrogen and the formation of U(1) in equilibrium with UN phase. In addition the vapour phase has U(g) and UN(g). The vapour pressure of U(g) and UN(g) are measured and their dependence with temperatures can be represented by: log(p U (Pa))=[(10.59±0.18)-(26857±357)/T(K)] (1757 UN (Pa))=[(12.19±0.57)-(37347±235)/T(K)] (2190 f G 0 (UN, g, T)(kJ/mol)=352.75-0.0494 T(K). The equilibrium constants for the dissociation of UN(s)(K 1 ) and UN(g)(K 2 ) into gaseous elements are given by: log(K 1 )=(13.03±0.18)-(42857±357)/T(K), log(K 2 )=(0.84±0.60)-(5510±427)/T(K). (orig.)

Rockere og bandemedlemmers kriminelle karrierer og netværk i ungdommen

DEFF Research Database (Denmark)

Klement, Christian; Pedersen, Maria Libak

2013-01-01

rockergruppe eller en bande, da viden om sådanne mønstre kan hjælpe til at forudsige, hvilke unge der fremadrettet er i risiko for at blive involveret. Undersøgelsesmaterialet består af oplysninger om de personer, der er registreret som rockere eller bandemedlemmer i Politiets Efterretningsstøtte Database (PED......Denne rapport omhandler en undersøgelse af rockere og bandemedlemmers kriminelle karriere og kriminelle netværk i ungdomsårene og i den tidligere voksenalder. Formålet med undersøgelsen er at identificere eventuelle mønstre i kriminaliteten hos unge, der senere i livet bliver medlemmer af en......) og af kriminalitetsoplysninger fra Danmarks Statistik. I analyserne af den kriminelle karriere er der gjort brug af matchede kontrolper-soner, således at de personer, der senere bliver medlemmer af en rockergruppe eller en bande, sam-menlignes med andre lovovertrædere, der ligner dem med hensyn til...

Interaktive Visualisierung von Abständen und Ausdehnungen anatomischer Strukturen für die Interventionsplanung

Science.gov (United States)

Rössling, Ivo; Cyrus, Christian; Dornheim, Lars; Hahn, Peter; Preim, Bernhard; Boehm, Andreas

Im Rahmen der Interventionsplanung muss der Chirurg therapierelevante Entscheidungen auf Basis räumlicher Relationen anatomischer Strukturen treffen. Interaktive 3D-Visualisierungen unterstützen diesen Prozess qualitativ. Quantitative Fragestellungen (Tumorausdehnung, Infiltrationstiefe, etc.) erfordern die Integration einer Bemaßung, deren Nutzen wesentlich von einer geeigneten Darstellung abhängt. In dieser Arbeit haben wir allgemeine Kriterien für die Eignung von Visualisierungen von Bemaßungen in interaktiven 3D-Szenen erarbeitet. Daran orientierend haben wir verschiedene Varianten der Darstellung von Abständen und Ausdehnungen anatomischer Strukturen betrachtet und ihr Erscheinungsbild hierzu zweckmäßig parametrisiert. Die Ausprägungen dieser Darstellungsparameter wurden in einer Studie auf ihre visuellen Wirkung hin an Chirurgen evaluiert. Es zeigte sich, dass die befragten Mediziner höchsten Wert auf Kohärenz und klare Zuordnung der Bemaßung setzten und überraschenderweise dafür sogar Abstriche in der direkten Lesbarkeit in Kauf nahmen.

Entitlement to vote in the Canton of Geneva and entitlement to vote and eligibility for election in the Canton of Vaud

CERN Multimedia

DG Unit

2011-01-01

You are reminded that, at commune level, certain international civil servants and their family members: are entitled to vote in the Canton of Geneva are entitled to vote and are eligible for election in the Canton of Vaud. For further information, in particular regarding the special procedure to be followed to apply to exercise these entitlements, you are invited to consult the information published, in French only, on the Swiss Mission’s website (topic « Privileges and immunities (Manual) » : http://www.eda.admin.ch/eda/fr/home/topics/intorg/un/unge/gepri/manvot/manvt1.html (for the Canton of Geneva), http://www.eda.admin.ch/eda/fr/home/topics/intorg/un/unge/gepri/manvot/manvt2.html (for the Canton of Vaud). The dates of the forthcoming ballots are available on the official websites of the cantonal administrative authorities : for Geneva: http://www.ge.ch/votations-elections/prochains-scrutins/; for Vaud: http://www.vd.ch/fr/themes/etat-droit-financ...

Abstract: SMAG PÅ SKOLEMAD

DEFF Research Database (Denmark)

Mithril, Charlotte Elisabeth; Kamuk, Anette

En sund kost er vigtig for at sikre optimal vækst, udvikling og sundhed hos børn og unge. Der er derfor stor fokus på strategier, der kan fremme sundere kostvaner hos børn og unge, og her er skolemaden blevet et centralt omdrejningspunkt. Men hvad skal der til for, at eleverne spiser (og elsker...... velsmagende skolemad. Vi fandt, at hvis skolemadsordninger skal tilbyde velsmagende og sunde måltider skal det samtidig være et velfungerende aktiv for skolerne, hvor eleverne inddrages og bruger deres smag bevidst. Det anbefales at: 1) skolens ledelse samtænker skolemadsordninger og pædagogiske aktiviteter......) den sunde skolemad? Her spiller smagen en vigtig rolle. Hovedformålet har været at belyse praksis knyttet til arbejdet med smag i skolemadsordninger. Målet er at bidrage til, hvordan denne praksis kan understøttes og udvikles, således at smag som ressource og motivationsfaktor kan blive en drivkraft...

Hvorfor fænger Facebook?

DEFF Research Database (Denmark)

Larsen, Malene Charlotte

2008-01-01

Facebook-feberen raser i Danmark. Online social networking er blevet mainstream og er ikke længere forbeholdt generationen af digitale indfødte. Facebook er et tydeligt bevis på, at vi voksne styres af nøjagtig de samme grundlæggende sociale behov, som når de unge bruger Arto, MySpace eller...... lignende sociale netværk. Vi voksne vil også have mange links på vores vennelister. Vi drages af den konstante tilstedeværelse, som Facebook giver os mulighed for. Og vi elsker at lure, snage og sladre. Derfor fascinerer Facebook. Og derfor er online social networking kommet for at blive. Men hvad er det...... vil jeg gå bag om Facebook-fænomenet ved at drage paralleller til børn og unges brug af sociale netværkssider – der er nemlig mange ligheder – og derved give svar på spørgsmålet: Hvorfor er Facebook så fængende?...

En tegning af æstetik 2013

DEFF Research Database (Denmark)

Buhl, Mie; Ejsing-Duun, Stine

2013-01-01

Denne artikel fremstiller skredet fra det individuelle fokus til den sociale forhandling omkring en situation, som er det nye perspektiv indenfor æstetik. Derigennem identificeres tendenser som er med til at udgøre platformen for børn og unges kulturer, hvor det handler om, at et æstetisk system er...... selvproducerende og stiller sig til rådighed for erkendelse. Disse kulturer udfolder sig i formater, som skolen ikke er gearet til at imødekomme. Som eksempel ville DrawSomething vanskeligt kunne begrundes i forhold til billedkunstfagets af ministeriet fastsatte ”fælles mål” – eller kan det? En central udfordring...... er, hvordan der skal arbejdes med æstetiske praksisformer i en nutidig læringskontekst, når børn og unges kulturer udfolder og udvikler sig i formater, der er præget af foranderlighed og flygtighed; af en uendelig skaben for nogen og med nogen og af situationer, der bebos med attituder? Vi diskuterer...

På kanten af ungdomslivet

DEFF Research Database (Denmark)

Sørensen, Niels Ulrik; Pless, Mette

2015-01-01

). Parallelt hermed fortælles moderne ungdomsliv (i ungdomssociologien) frem gennem ”…theoretical frameworks based on urban experiences which capture neither the lives of rural young people nor the spatial dimensions of the structures and cultures that make up contemporary youth.” (Farrugia 2013......, at yderområder er hårdt ramt af ungdomsarbejdsløshed (Bjørnsted & Andersen 2013), at områderne er præget af høj koncentration af unge med arbejderklassebaggrund (Ottosen et a 2010), mens de uddannelsesorienterede og ressourcestærke unge er tilbøjelige til at flytte væk og ind til byerne (Helve 2003). Og ser man...... stedstilknytning og stedbundne ressourcer. Teoretiske perspektiver, der peger på vigtigheden af en mere ”..spatialised youth sociology that is sensitive to macro-level processes producing different spaces, as well as the local, emplaced ways in which young people are responding to social changest hat shape...

Når specialer gør en forskel

DEFF Research Database (Denmark)

Dirckinck-Holmfeld, Lone; Iversen, Torben; Konnerup, Ulla

2008-01-01

I denne antologi fremlægger og diskuterer en række forskere deres konkrete erfaring med og overvejelser over didaktisk design og brugen af digitale medier i forskellige undervisnings- og læringskontekster fra grundskole til universitetsniveau. Bogens tre dele behandler: Børns og unges brug af dig...

Metoder til den børnefaglige undersøgelse

DEFF Research Database (Denmark)

Sørensen, Kresta Munkholt

Denne afhandling omhandler rammerne for sagsbehandlingen i forhold til udsatte børn, unge og deres familier. Afhandlingen er centreret omkring, hvordan socialarbejderne oplever metoderne til den børnefaglige undersøgelse, og er udarbejdet i et komparativt perspektiv med fokus på følgende tre...

Animated Symbols

DEFF Research Database (Denmark)

Frolunde, Lisbeth

Afhandlingen omfatter et case studie der belyser hvordan unge lærer ved at designe, eller producere, multimedie tekster, her med fokus på animationsfilm. Empiri består af film, fotos, storyboards skabt af 21 elever på et dansk gymnasium, samt videooptagelser og interviews. De semiotiske 'design...

Netværksanbringelser

DEFF Research Database (Denmark)

Bonfils, Inge Storgaard; Mehlbye, Jill; Raft Andersen, Karen

Socialt udsatte børn og unge kan have stor gavn af at blive anbragt i pleje hos nær familie eller venner. Men plejeforældrene skal uddannes og støttes mere, end de bliver i dag. Danmark kan lære af Norge og Sverie....

Globalisering, pædagogik og ungdom - i Syd

DEFF Research Database (Denmark)

Madsen, Ulla Ambrosius

2007-01-01

Artiklen introducerer til teorier om sammenhængen mellem globalisering, pædagogik og ungdom. Med udgangspunkt i etnografiske, komparative studier af skole og lungdom i Vietnam, Zambia og Brasilien diskuteres forholdet mellem uddannelsespolitiske tiltag, pædagogiske reformer og unges dannelse. Det...

Pizza, Kattekilling og Bombebælte

DEFF Research Database (Denmark)

Nissen, Thomas Elkjer

2016-01-01

Religiøs og moralsk overlegenhed, opbygningen af en ny nation og vold som strategisk sprog er grundelementerne i det narrativ der har gjort Islamisk Stats propaganda og rekrutteringsbudskaber så effektfulde. Narrativet virker tiltrækkende på mange unge mennesker – herunder vesterlændinge. Ikke ku...

Nicholas Steno and Renè Descartes

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2009-01-01

Den danske videnskabsmand Niels Steensen (1638-86) læste allerede som ung student Renè Descartes og blev grebet af hans metode, som han forblev tro i hele sit videnskabelige virke. Cartesianismen kan beskrives som Steensens videnskabelige paradigme (Kuhn), men det var også et paradigme, han testede...

Den rekreative værdi af udrensning i eg

DEFF Research Database (Denmark)

Skovsgaard, Jens Peter; Jensen, Frank Søndergaard; Meilby, Henrik

2017-01-01

Professionelle forstfolk i Nordeuropa foretrækker ung egeskov, som er udrenset hårdt og derfor er meget åben. I Mellem- og Sydeuropa foretrækkes svagere udrensning, som giver tættere bevoksninger. Forskellene er formodentlig kulturelt betingede og afspejler forskelle i uddannelsen af skovfogeder ...

Brobygning 3.0

DEFF Research Database (Denmark)

Høgh, Mona Irene; Schlüntz, Ditte Annette; Pedersen, Annette Kastrup

2016-01-01

Denne rapport præsenterer evalueringen af Projektet Brobygning 3.0 – nye koblinger af uddan-nelse og erhvervspraksis for kvalificering og understøttelse af unges uddannelsesvalg. Projektet har delvist været finansieret af Region Sjælland i forbindelse med satsningen Kompetenceparat 2020 og kobler...

Residential child care

DEFF Research Database (Denmark)

Jensen, Niels Rosendal

2013-01-01

Anmeldelsen gennemgår Connelly og Milligans præsentation af skotske døgninstitutioner ved at placere dette tema inden for rammerne af socialpolitikken og ved at pege på spændingen mellem børns hhv. unges ønsker og de muligheder, stederne kan tilbyde....

Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies.

Science.gov (United States)

Durandy, Anne; Taubenheim, Nadine; Peron, Sophie; Fischer, Alain

2007-01-01

B-cell intrinsic immunoglobulin class switch recombination (Ig-CSR) deficiencies, previously termed hyper-IgM syndromes, are genetically determined conditions characterized by normal or elevated serum IgM levels and an absence or very low levels of IgG, IgA, and IgE. As a function of the molecular mechanism, the defective CSR is variably associated to a defect in the generation of somatic hypermutations (SHMs) in the Ig variable region. The study of Ig-CSR deficiencies contributed to a better delineation of the mechanisms underlying CSR and SHM, the major events of antigen-triggered antibody maturation. Four Ig-CSR deficiency phenotypes have been so far reported: the description of the activation-induced cytidine deaminase (AID) deficiency (Ig-CSR deficiency 1), caused by recessive mutations of AICDA gene, characterized by a defect in CSR and SHM, clearly established the role of AID in the induction of the Ig gene rearrangements underlying CSR and SHM. A CSR-specific function of AID has, however, been detected by the observation of a selective CSR defect caused by mutations affecting the C-terminus of AID. Ig-CSR deficiency 2 is the consequence of uracil-N-glycosylase (UNG) deficiency. Because UNG, a molecule of the base excision repair machinery, removes uracils from DNA and AID deaminates cytosines into uracils, that observation indicates that the AID-UNG pathway directly targets DNA of switch regions from the Ig heavy-chain locus to induce the CSR process. Ig-CSR deficiencies 3 and 4 are characterized by a selective CSR defect resulting from blocks at distinct steps of CSR. A further understanding of the CSR machinery is expected from their molecular definition.

De Vilde Unge i Aalborg Øst

DEFF Research Database (Denmark)

Jensen, Sune Qvotrup

og institutioner, småkriminalitet, hip hop stil, en tendens til at strejfe i rundt i byens rum samt en ekspressiv form for maskulinitet. Et af bogens vigtigste budskaber er, at skabelsen af en kollektiv subkultur med disse træk må forstås og forklares som en reaktion på, eller en kreativ bearbejdning...

Implementering af tre misbrugsbehandlinger for udsatte unge

DEFF Research Database (Denmark)

Weatherall, Cecilie Dohlmann; Termansen, Tina

2015-01-01

SFI- Det Nationale Forskningscenter for Velfærd skal evaluere ”Projekt misbrugsbehandling for udsatte unge”, som løber fra 2011 til 2014. De tre behandlingsmodeller, som indgår i Socialstyrelsens (SOS) ”Projekt misbrugsbehandling for udsatte unge”, er MST-SA (Multi Systemic Therapy Substance Abuse...... både i Danmark og internationalt. Dog er der et stigende fokus på, at det er et centralt element for at opnå gode evalueringer (Fixen m.fl., 2005; Fixen m.fl., 2009; Durlak & DuPre, 2008), idet implementeringen af en indsats kan have stor betydning for den effekt, der observeres. Ifølge Durlak og Du...

Melkersson-Rosenthals syndrom hos en ung mand

DEFF Research Database (Denmark)

Lauritzen, Elisabeth; Jørkov, Andreas P Schjellerup

2017-01-01

A 24-year-old man presented with orofacial swelling, peripheral facial palsy and fissured tongue. Apart from a previous episode of peripheral palsy, he had no history of illness. Biopsy of the lip, blood tests, magnetic resonance imaging of the head and lumbar puncture showed no pathology. He rec...

Børn, unge og grøntsager

DEFF Research Database (Denmark)

Stacey, Julia; Søndergaard, Helle Alsted

2003-01-01

Selv om børnefamilier i dag har travlt, prioriterer de at samles omkring middagsbordet hver aften, og de vil have sund og hjemmelavet mad. Men ét er idealet, noget andet er virkeligheden i en travl hverdag. Derfor ender de nemme og hurtige løsninger lidt for ofte på middagsbordet i mange børnefam...

Hovedpine hos børn og unge

DEFF Research Database (Denmark)

Gren, Caroline; Vogler, Kristoffer; Miranda, Maria Jose

2018-01-01

Headache is an increasingly common symptom among children and adolescents with a prevalence of 58.4%, and it may have profound impact on everyday life. A poorer prognosis is seen for children, who are not referred to specialist care, and long-term follow-up is shown to indicate a better outcome. ...

Social praksisteoretiske analyser af unge i partnerskaber

DEFF Research Database (Denmark)

Mørck, Line Lerche; Munkholm, Merete

Denne bog analyserer lokale partnerskaber mellem produktionsskoler og virksomheder, institutioner og civilsamfund. Bogen illustrerer, hvordan vi med social praksis teori kan forstå partnerskaber som grænsefællesskaber, hvor partnerskaber arrangeres i og på tværs af forskellige fællesskaber og han...

Unge og kommunalvalg - fra holdning til handling

OpenAIRE

Bordinggaard Madsen, Anders; Retz Frøslev, Liv; Borelli, Benjamin; Schnedler Henriksen, Jesper; Gebremichael, Matiwos

2014-01-01

It has long been a concern that the election turnout at the municipal elections were considerably lower than the elections at the Danish parliament. Especially the younger voters does not participate at the municipal elections. This is a worrying tendency and in this paper we investigate how the situation can be improved. In addition to that we will make a focus group investigation in this paper, where we will find out how the six young first time voters relate to the communication campaign: ...

Lage kostprijs biedt ruimte voor de toekomst (1)

NARCIS (Netherlands)

Evers, A.; Haan, de M.

2001-01-01

In dit artikel volgen we de geldstroom van netto bedrijfsresultaat naar netto kasstroom op het gemiddelde Nederlandse melkveebedrijf dat qua omvang en intensiteit vergelijkbaar is met het lagekostenbedrijf.

75 FR 20413 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of a...

Science.gov (United States)

2010-04-19

... volume levels in non-Premium Tier Penny Pilot issues. This new tiered pricing structure will replace the.... The Exchange also proposes to introduce a Premium Tier for electronic transactions in certain Penny..., UNG, FAZ, DIA, GDX, and USO will qualify for the Premium Tier, and will receive an additional $.05 per...

Schrodinger's cat versus Darwin

OpenAIRE

Silagadze, Z. K.

2009-01-01

Sun Wu-k'ung, an immortal Monkey-King of Chaos learns modern physics from the Patriarch Bodhi and questions the Darwinian evolution. He finds that the modern physics indicates towards the intelligent design as a vastly more probably origin of humans than the random evolution by mutations and natural selection.

Mødet med det Andet

DEFF Research Database (Denmark)

Marchwinski, Alena

2002-01-01

Da Christen Købke i 1830 malte sitt bilde fra Kunstakademiets avstøpningssamling på Charlottenborg, skildret han en situasjon som vordende danske kunstnere hadde vært fortrolige med i flere generasjoner: en ung mann betrakter en avstøpning av en antikk skulptur. Med utgangspunkt i kombinasjonen a...

Wajdi al-Ahdal and the Broken Yemeni Nation

DEFF Research Database (Denmark)

Hebbelstrup, Søren

2015-01-01

Kapitlet undersøger en roman af den unge Yemenitiske forfatter "Wajdi al-Ahdal" og sammenligner det med et "klassisk" yemenitisk værk fra den post-revolutionære æra. I kapitlet argumenteres der for, at den intellektuelle samfundsklasse i Yemen stadig finder inspiration i nationale og islamiske...

Hiphopkulturen – et fællesskabende og frigørende mulighedsrum?

DEFF Research Database (Denmark)

Elkjær, Lea; Tybjerg, Gry; Stenberg Andersen, Mira

2015-01-01

Artiklen undersøger, hvorvidt og hvordan hiphopkulturen kan anvendes som et fællesskabende og frigørende mulighedsrum for unge i såkaldt ghettostemplede områder. Artiklen udspringer af et treårigt igangværende praksisforskningsprojekt i kultur – og fritidstilbuddet Livsbanen i Tingbjerg - Husum o...

An Essay on the Qualities of Artistic Performance, Creativity and Aesthetic Understanding

DEFF Research Database (Denmark)

Thomsen, Eddy Preben; Rothuizen, Jan Jaap; Hansen, Martin

2010-01-01

Arbejdspapir til EU-projektet om validering af ikke-formel og uformelle læreprocesser i sociale fællesskaber og kreativ industri, med særligt henblik på unge træneres eller undervisere/tutoreres muligheder for at opnå realkompetence i overensstemmelse med EU Framework for kvalitetssikring i...

Optically Controlled Quantum Dot Spins for Scaleable Quantum Computing

National Research Council Canada - National Science Library

Steel, Duncan G

2006-01-01

.... Sham is responsible for theoretical support & concept development. The group at Michigan along with this QuaCGR student are responsible for experimental demonstration of key experimental demonstrations for quantum computing...

Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

DEFF Research Database (Denmark)

Singla, Rashmi

Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

Sociale medier i ungdomslivet

DEFF Research Database (Denmark)

Larsen, Malene Charlotte; Lange, Jon Kristian

2014-01-01

Brugen af sociale medier er en integreret del af langt de fleste danske unges hverdagsliv. De 16-24-årige er den del af befolkningen, som er kraftigst repræsenteret på sociale medier som Facebook, Instagram, Snapchat og Twitter. I denne aldersgruppe er stort set alle tilknyttet en eller flere...

Hvorfor bliver de ikke?

DEFF Research Database (Denmark)

Ulriksen, Lars; Madsen, Lene Møller; Holmegaard, Henriette Tolstrup

2011-01-01

fag (STEM-uddannelserne). Vi tager afsæt i Seymour & Hewitts (1997) etnografiske undersøgelse hvorefter hovedlinjerne i forskningen siden år 2000 præsenteres. Vi giver sammenhængen mellem frafald og unges identitetsarbejde et særskilt blik, og diskuterer, hvorvidt dette er en af de nye veje til...

På vej mod ungdomskriminalitet

DEFF Research Database (Denmark)

Olsen, Rikke Fuglsang; Dahl, Karen Margrethe; Poulsen, Maria Hedemark

. 7-, 11-, 15- og 18-årsalderen. Den giver omfattende og detaljeret viden, om hvilke risikofaktorer, man i et forebyggelsesperspektiv skal være opmærksom på, når man vil identificere unge, der kan have gavn af kriminalitetsforebyggende indsatser. Samtidig fremhæves de beskyttende faktorer, som kan...

May I come to visit you at work?

DEFF Research Database (Denmark)

Klausen, Bodil

2016-01-01

Artiklen beskriver faglige oplevelser fra et længerevarende studiebesøg, hvor en lektor har fulgt en praktiker - "shadowing". I dette tilfælde en irsk pædagog, der arbejder hos YAPS: Youth Action Project Sligo, der er et samarbejde mellem politiet og sociale myndigheder i forhold til unge mellem ...

Ensenanza basada en el diálogo

DEFF Research Database (Denmark)

Bernhardt, Nana; Dysthe, Olga; Esbjørn, Line

Hvad er dialogbaseret undervisning, og hvordan kan den udfolde sig på et kunstmuseum? I denne bog viser forfatterne, hvordan erfarne museumsundervisere møder børn og unge på syv museer og udfordrer dem til nysgerrigt og kreativt at udforske temaer, udveksle synspunkter og udvikle nye tanker og id...

Kapitalismens ånd og den kreative etik

DEFF Research Database (Denmark)

Stephensen, Jan Løhmann

Chiapellos tese om kapitalismens permanente behov for ny legitimering analyserer Jan Løhmann Stephensen nutidens koblinger mellem arbejde, kreativitet og økonomi som et svar på de kritikker af kapitalismen og lønarbejdet, som blev fremsat i anden halvdel af det 20. århundrede, typisk med den unge Karl Marx...

Person-centered care

DEFF Research Database (Denmark)

2014-01-01

Partnerskaber i den psykiatriske behandling, hvad vil det sige? Det kan du se mere om i denne lille film der bygger på interviews med en gruppe unge med ny-diagnosticeret skizofreni. Filmen formidler hvad brugerinvolvering er fra et patientperspektiv, og hvilke værdier mødet mellem patienter og s...

Når identiteter stemmer overens med selvet

DEFF Research Database (Denmark)

Ravn, Ib

2017-01-01

Spørgsmålet om identitetsdannelse er centralt i psykologien. Store børn og unge menneskers udvikler deres identitet ved at undersøge og afprøve forskellige roller og tilknytninger. Hvordan kan man psykologisk-videnskabeligt beskrive denne proces, ikke mindst hvordan den kan føre til psykisk sundh...

Misting cooling technique for protected culture of Oncidium orchids ...

African Journals Online (AJOL)

user

2012-10-04

Oct 4, 2012 ... 2Department of Bio-industrial Mechatronics Engineering, National Ch5ungHsing University, 250 Kuokuang Road,. Taichung, Taiwan. ... In this study, mechanical ventilation fans with intermittent misting were ... are in Taiwan and Malaysia. .... An 11.0 × 30 × 3.5 m high, 1155 m3 volume, plastic-glazed steel-.

Med det sociale som designmateriale

DEFF Research Database (Denmark)

Brandt, Eva; Binder, Thomas

2016-01-01

Samarbejde, samskabelse og social nysgerrighed er i dag en præmis for den nyskabende designer. Det sociale er det nye designmateriale som unge designere giver sig i kast med når f.eks. Emmy Linde samarbejder med plejehjemsbeboere, deres pårørende, plejepersonale og fysioterapeuter for at designe ...

A study of young Parisian speech

DEFF Research Database (Denmark)

Hansen, Anita Berit

2012-01-01

Fransk talt i Paris har gennem århundrede udgjort en model for den øvrige franske befolkning. Udtalen er dog på ingen måde fri for variation eller forandring. Artiklen behandler udtalen hos 9 unge parisere (såvel studerende som personer med kort teknisk uddannelse), der tydeligvis deltager i flere...

Wohnungsmärkte im deutschen Ost-West-Vergleich

Directory of Open Access Journals (Sweden)

Gerd Rothenwallner

2003-12-01

Full Text Available Despite equal conditions after World War II, housing markets in East and West Germany had, according to the political and economic systems, developed completely different. State controlled mass production of dwellings due to planned economy is faced with house building under control of market principles. Bringing together both housing mar-kets is one of the most urgent political tasks since reunification.

13.-20. VI võtab ehtekunstnike rühmitus F.F.F.F....

Index Scriptorium Estoniae

2004-01-01

Rühmitus F.F.F.F. (Ketli Tiitsar, Kristi Paap, Kaire Rannik, Berit Teeäär, Maria Valdma) võtab osa Bostonis toimuvast rahvusvahelisest ehtekunstinäitusest ja konverentsist "ContacT 2004", juhendab Massachusetts College of Art üliõpilastele ja kunstnikele korraldatud workshop'i "SWOP". Bakalar Gallerys esineb rühmitus näitusega "Igapäevaleib", osalejate individuaalset loomingut eksponeerib galerii Mobilia

Bazar iqtisadiyyatinin f ə LS ə fi̇ t ə hli̇li̇

OpenAIRE

Məəmməədov, H.

2014-01-01

«Market» and «market economy» is different from each other. Only market economy is connected with capitalism. Philosophical analysis of mar- ket economy include some factors, but three of them are more important: pricing, management of market economy and state regulation of market. Market equilibri- um depends on these factors. State regulation of market is essential factor because of market failure

Indie eller klassisk retro?

DEFF Research Database (Denmark)

Thorlacius, Lisbeth

2009-01-01

Begrebet retro henviser til ting, attituder og fænomener fra en nylig forgangen tid. Modetrends og stilarter fra 50'erne, 60'erne, 70'erne og 80'erne florerer og blandes i stigende grad i begyndelsen af det 21. århundrede. Især blandt unge manifesterer "neo-stammer" deres sammenhold gennem fælles...

Identifying suspects by matching hand photographs with video evidence

DEFF Research Database (Denmark)

Busch, Johannes Rødbro; Lynnerup, Niels

2015-01-01

Unge under 15 rapporterer ikke sjældent at have været udsat for seksuelle relationer imod deres vilje. I nogle tilfælde kan pornografiske optagelser være en del af overgrebet. Sådant materiale kan bidrage til identificering af gerningspersonen. I dette studie undersøgtes anvendelsen af visuel sam...

Mit barn er anbragt

DEFF Research Database (Denmark)

Nissen Møller, Sanne; Skytte Aalborg Universitet, Marianne

Anbringelse af etniske minoritetsbørn og -unge udgør en voksende opgave for kommunerne. I denne bog belyses gennem 11 personlige livshistorier de særlige problemer og dilemmaer, som etniske minoritetsforældre står i, når deres barn anbringes. Livshistorierne giver et indblik i, hvordan forældrene...

Operation New Arrivals. Phase I - The Buildup, 27 April 1975 - 23 May 1975. Part I

Science.gov (United States)

1975-07-01

la nbvbg nba Ian bao chuyen-nghlep, na ohi la nhSng ngvicfl oo thlen« eh£, ohUng ehung tol üde-aong Dear Conpatrlote i Away fron our natlTe land...field, places for badmitten, basketball , and volleyball playing. (4) A newspaper in Vietnamese for the center is in production. Contributions of

“So under ‘cause for concern’, I’ll write that…”

DEFF Research Database (Denmark)

Aamann, Iben Charlotte; Dybbroe, Betina

2017-01-01

Målet med artiklen er at pege på og diskutere hvordan klasse får betydning for i public health interventions in schools Forebyggelse af risici og sundhedsfremme for børn og unge er i dag centrale i sundhedspolitik, samtidig med at forældrepraksis anses for determinerende for barnets sundhed og tr...

Refleksion og fællesskab

DEFF Research Database (Denmark)

Valgreen, Helene

og fælles refleksioner. Grundlaget for analysen er Grounded Theory. Projektet er på én og samme tid forskning og metodeudvikling og tager udgangspunkt i forskningsspørgsmålet: ”Hvis karrierevejledningens mål er at sikre at alle unge, uanset deres sårbarhedsgrad, skal kunne drage fordel af et...

DVD anmeldelse - En Verden af Lyd og Musik

DEFF Research Database (Denmark)

Holck, Ulla

2006-01-01

Anmeldelse af DVD-udgivelse af Claus Bang (2005): En Verden af Lyd og Musik. Musikterapi for døve, hørehæmmede og multihandicappede børn og unge. Al tale med undertekst eller tegnsprogstolkning. DVD-boks med 3 stk. dobbeltlag DVD beregnet til afspilning på PC. Udgivet af Musikterapi-foreningen En...

Forskning i musikterapi - børn med fysiske og psykiske funktionsnedsættelser

DEFF Research Database (Denmark)

Holck, Ulla

2013-01-01

samspil. Samtidig er det muligt at udtrykke frustration, vrede og sorg gennem musik, så børn og unge med fysiske og psykiske funktionsnedsættelser, der har svært ved at udtrykke og bearbejde følelsesmæssige og relationelle problemer, kan opbygge positive relationserfaringer og styrke selvfølelsen vha...

Fucking mange tusser

DEFF Research Database (Denmark)

Olesen, Annette; Jensen, Sune Qvotrup

2009-01-01

Artiklen diskuterer resultaterne af et etnografisk feltarbejde blandt kriminaliserede unge mænd med etnisk minoritetsbaggrund i Århus. Forfatterne ønsker at at vise, at der mangler noget grundlæggende i forståelsen af visse kriminalitetsmønstre, der udvikles på kanten af samfundet, og som først o...

Tilgængelig, nærværende og potentiel fraværende

DEFF Research Database (Denmark)

Winther, Ida Wentzel

2007-01-01

At have en mobiltelefon er blevet hver mands eje. Der kommunikeres som aldrig før, alle steder og hele tiden. Vi er tilgængelige døgnet rundt. Denne artikel tager udgangspunkt i et interaktionistisk baseret observationsstudie i en ungdomsklub i Danmark og fokuserer på, hvordan unge i alderen 12-1...

Evaluering af tre projekter i Socialstyrelsens Forældreprogram - Resultatresumé

DEFF Research Database (Denmark)

Andersen, Luna Kragh; Scavenius Sonne-Schmidt, Christoffer

2018-01-01

ADHD og ADHD-lignende udfordringer er nogle af de mest udbredte former for psykiske proble-mer hos børn og unge (Dick & Ferguson, 2015). Forskning finder, at diagnosen kan stilles hos mindst 5 pct. af en børneårgang, hvilket svarer til 1-2 børn i hver skoleklasse (Polanczyk m.fl., 2007, 2014......; Thomas m.fl., 2015; Willcutt, 2012). Samtidig er ADHD og ADHD-lignende udfordrin-ger forbundet med negative konsekvenser, som har både en personlig pris og en samfundsmæs-sig pris, som fx behov for ekstra støtte i skolen eller særlige skoletilbud, forøget brug af sundhedsydelser og sociale ydelser og...... arbejdsmarkedet, et problempræget forhold til egne børn samt angst, depression og tidlig død (Loeber & Burke, 2011; Skogen & Torvik, 2013). I dag betragtes ADHD som en langvarig eller kronisk sygdom, men mestringsfremmende indsatser kan hjælpe forældre, børn og unge til bedre at håndtere symptomer på ADHD samt...

Entitlement to vote in the Cantons of Geneva and Vaud and eligibility for election in the Canton of Vaud

CERN Multimedia

2006-01-01

The Permanent Mission of Switzerland has informed CERN that some international civil servants and members of their families are henceforth entitled to vote on commune matters in the Canton of Geneva and are entitled to vote and are eligible for election at commune level in the Canton of Vaud. For further information, in particular regarding the special procedure to be followed to apply to exercise this entitlement, you are invited to consult the information published, in French only, on the Swiss Mission's website: http://www.dfae.admin.ch/eda/fr/home/topics/intorg/un/unge/gepri/manvot/manvt1.html (for the Canton of Geneva), http://www.eda.admin.ch/eda/fr/home/topics/intorg/un/unge/gepri/manvot/manvt2.html (for the Canton of Vaud), In this regard, you are reminded that: Under Articles I 3.05 and I 3.07 of the Staff Rules, a member of the personnel 'may take part, outside the Organization, in the public and political life of a State in accordance with the relevant legislation' and 'express his own person...

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.

Science.gov (United States)

Lauritzen, Knut H; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye-Knudsen, Morten; Gjedde, Albert; Klungland, Arne; Bohr, Vilhelm A; Storm-Mathisen, Jon; Bergersen, Linda H

2016-12-01

Mitochondrial genome maintenance plays a central role in preserving brain health. We previously demonstrated accumulation of mitochondrial DNA damage and severe neurodegeneration in transgenic mice inducibly expressing a mutated mitochondrial DNA repair enzyme (mutUNG1) selectively in forebrain neurons. Here, we examine whether severe neurodegeneration in mutUNG1-expressing mice could be rescued by feeding the mice a ketogenic diet, which is known to have beneficial effects in several neurological disorders. The diet increased the levels of superoxide dismutase 2, and mitochondrial mass, enzymes, and regulators such as SIRT1 and FIS1, and appeared to downregulate N-methyl-D-aspartic acid (NMDA) receptor subunits NR2A/B and upregulate γ-aminobutyric acid A (GABA A ) receptor subunits α 1 . However, unexpectedly, the ketogenic diet aggravated neurodegeneration and mitochondrial deterioration. Electron microscopy showed structurally impaired mitochondria accumulating in neuronal perikarya. We propose that aggravation is caused by increased mitochondrial biogenesis of generally dysfunctional mitochondria. This study thereby questions the dogma that a ketogenic diet is unambiguously beneficial in mitochondrial disorders. Copyright © 2016 Elsevier Inc. All rights reserved.

A Gateway MultiSite recombination cloning toolkit.

Directory of Open Access Journals (Sweden)

Lena K Petersen

Full Text Available The generation of DNA constructs is often a rate-limiting step in conducting biological experiments. Recombination cloning of single DNA fragments using the Gateway system provided an advance over traditional restriction enzyme cloning due to increases in efficiency and reliability. Here we introduce a series of entry clones and a destination vector for use in two, three, and four fragment Gateway MultiSite recombination cloning whose advantages include increased flexibility and versatility. In contrast to Gateway single-fragment cloning approaches where variations are typically incorporated into model system-specific destination vectors, our Gateway MultiSite cloning strategy incorporates variations in easily generated entry clones that are model system-independent. In particular, we present entry clones containing insertions of GAL4, QF, UAS, QUAS, eGFP, and mCherry, among others, and demonstrate their in vivo functionality in Drosophila by using them to generate expression clones including GAL4 and QF drivers for various trp ion channel family members, UAS and QUAS excitatory and inhibitory light-gated ion channels, and QUAS red and green fluorescent synaptic vesicle markers. We thus establish a starter toolkit of modular Gateway MultiSite entry clones potentially adaptable to any model system. An inventory of entry clones and destination vectors for Gateway MultiSite cloning has also been established (www.gatewaymultisite.org.

Aprendizagens em movimento: Um experimento de estímulo ao Pensamento Computacional de docentes com M-Learning e U-Learning

Directory of Open Access Journals (Sweden)

Guaraci Vargas Greff

2018-03-01

Full Text Available Este artigo relata a experiência de prática pedagógica de pensamento computacional em sala de aula. Faz uso das aprendizagens móvel e ubíqua  na prática do Pensamento Computacional na construção de aplicativo para dispositivo móvel ou portátil através da ferramenta denominada App Inventor disponível no site do Instituto de Tecnologia de Massassuchets. A base teórica usada é as metodologias de inquérito incluindo: aprendizagem por descoberta, inquérito indutivo, instrução ancorada, estudo de caso e Aprendizagem Baseada em Problemas ou Projetos (ABP. Esta é uma pesquisa qualitativa de estudo de caso colaborativo que analisa e aplica a proposta de curso disponível no site, realiza análise do perfil dos entrevistados e apresenta opiniões sobre a atividade. Como resultados surgem aspectos relevantes do perfil docente para aprendizagem móvel e ubíqua, assim como orientações para a prática docente do Pensamento Computacional com as aprendizagens móvel e ubíqua em sala de aula, além da aceitação dos estudantes e docentes no uso de dispositivos móveis para aprendizagem de lógica de programação.

Mechanism of mRNA-STAR domain interaction: Molecular dynamics simulations of Mammalian Quaking STAR protein.

Science.gov (United States)

Sharma, Monika; Anirudh, C R

2017-10-03

STAR proteins are evolutionary conserved mRNA-binding proteins that post-transcriptionally regulate gene expression at all stages of RNA metabolism. These proteins possess conserved STAR domain that recognizes identical RNA regulatory elements as YUAAY. Recently reported crystal structures show that STAR domain is composed of N-terminal QUA1, K-homology domain (KH) and C-terminal QUA2, and mRNA binding is mediated by KH-QUA2 domain. Here, we present simulation studies done to investigate binding of mRNA to STAR protein, mammalian Quaking protein (QKI). We carried out conventional MD simulations of STAR domain in presence and absence of mRNA, and studied the impact of mRNA on the stability, dynamics and underlying allosteric mechanism of STAR domain. Our unbiased simulations results show that presence of mRNA stabilizes the overall STAR domain by reducing the structural deviations, correlating the 'within-domain' motions, and maintaining the native contacts information. Absence of mRNA not only influenced the essential modes of motion of STAR domain, but also affected the connectivity of networks within STAR domain. We further explored the dissociation of mRNA from STAR domain using umbrella sampling simulations, and the results suggest that mRNA binding to STAR domain occurs in multi-step: first conformational selection of mRNA backbone conformations, followed by induced fit mechanism as nucleobases interact with STAR domain.

Rockets and spacecraft: Sine qua non of space science

Science.gov (United States)

1980-01-01

The evolution of the national launch vehicle stable is presented along with lists of launch vehicles used in NASA programs. A partial list of spacecraft used throughout the world is also given. Scientific spacecraft costs are presented along with an historial overview of project development and funding in NASA.

Experiencing Photographs Qua Photographs: What's So Special about Them?

Directory of Open Access Journals (Sweden)

Jiri Benovsky

2013-01-01

Full Text Available Merely rhetorically and answering in the negative, Kendall Walton has asked: "Isn't photography just another method people have of making pictures, one that merely uses different tools and materials; cameras, photosensitive paper, and darkroom equipment, rather than canvas, paint, and brushes? And don't the results differ only contingently and in degree, not fundamentally, from pictures of other kinds?" Contrary to Walton and others, I answer with a resounding "Yes" to Walton’s questions in this article. It is a widely shared view that photographs are somehow special and that they fundamentally differ from hand-made pictures such as paintings, both from a phenomenological point of view (in the way we experience them and an epistemic point of view (since they are supposed to have a different that is, greater, epistemic value from paintings that gives us a privileged access to the world. I almost reject the totality of these claims and, as a consequence, there remains little difference between photographs and paintings. As we shall see, “photographs are always partly paintings,” a claim that is true not only of retouched digital photographs but of all photographs, including traditional ones made using photosensitive film and development techniques.

Decentralized Planning for Pre-Conflict and Post-Conflict ...

African Journals Online (AJOL)

Decentralized Planning for Pre-Conflict and Post-Conflict Management in the Bawku Municipal ... institutional arrangements for conflict monitoring and evaluation. Such processes are 'sine qua non' to pre-conflict and post-conflict prevention.

God Save the Queen

DEFF Research Database (Denmark)

Agger, Gunhild

2016-01-01

Netflix-serien The Crown (2016), der sætter fokus på den unge Elizabeth II, er et godt bud på en ny historisk serie med samme slags appel som Downton Abbey. Den har de samme grundlæggende kvaliteter. The Crown er fejende flot i sin gengivelse ikke kun af historiske begivenheder og kostumer, men...

Pædagoger og Perkere – etniske minoritetsbørn i det sociale system

DEFF Research Database (Denmark)

Vitus, Kathrine

: hvad gør mødet med en socialpædagogisk institution ved og for etniske minoritetsbørn? Hvilke praksisser, manøvremuligheder og handlerum har pædagoger? Hvorfor er mødet mellem danske velfærdsinstitutioner, deres professionelle og etniske minoritetsbørn, unge og deres familier tilsyneladende så svært? I...

A Comparative Comment on the Case Studies

DEFF Research Database (Denmark)

Kjeldsen, Christian Christrup; Ley, Thomas; Jensen, Niels Rosendal

2012-01-01

Denne konklusion sammenfatter hovedtrækkene af de gennemførte case studies i WorkAble-projektet. Vigtige pointer er, at unge på tværs af de forskellige case studies har vanskeligt ved at blive hørt og taget alvorligt. I stedet spises de af med "realistisk vejledning" eller dårlige uddannelses- og...

Frafald i erhvervsuddannelserne

DEFF Research Database (Denmark)

Op mod halvdelen af alle de unge, der starter på en erhvervsuddannelse, gennem­fører den ikke. De afbryder uddannelsen, falder fra eller skifter mellem forskellige uddannelser. Mange af dem er blevet en erfaring rigere og starter på en ny uddan­nelse, som de gennemfører. Men en alt for stor del af...

En længsel efter fællesskaber og kæft, trit og retning

DEFF Research Database (Denmark)

Steno, Anne Mia

2017-01-01

viderebearbejdninger og fokuseringer af min ph.d. ”Ungdomsliv i en uddannelsestid” (2015), hvor jeg fulgte grupper af unge, særligt drenge, over en periode på to år, fra de startede på henholdsvis et grundforløb til gastronomi og automekaniker. Afhandlingen handler om deres møder med en ungdomsuddannelse, deres...

Kok, køn og krop: mediekokke og maskuliniteter blandt kokkedrenge på erhvervsskolen

DEFF Research Database (Denmark)

Steno, Anne Mia; Friche, Nanna

2013-01-01

Interessen for mad, råvarer og gastronomi er stor i disse år. Forskning peger på, at kokkefagets brede popularitet i offentligheden virker til at tiltrække elever til uddannelsen. Mediekokke bliver forbilleder, og de unge vil gerne lære at lave den smarte mad, som de spiser på byens cafeer (Møberg...

Reformationens tøvende omfortolkning af kætterbegrebet

DEFF Research Database (Denmark)

Holm, Bo Kristian; Thomsen, Søren Feldtfos

2012-01-01

Denne artikel undersøger påstanden om en omfortolkning af kætterbegrebet i den lutherske reformation. Der argumenteres for, at det giver god mening at tale om nytænkning af kætterbegrebet hos den unge Luther i form af en internalisering af kætteriet, hvor den enkeltes eget syndige selv udpeges som...

Penge, (ud)dannelse, forbindelser eller brains?

DEFF Research Database (Denmark)

Holm, Anders; Jæger, Mads Meier

2004-01-01

kognitiv kapital. Analysen indikerer, at kulturel kapital er af størst betydning for, om unge vælger akademisk orienterede, videregående uddannelser, mens social kapital er af betydning for, om man opnår en faglig uddannelse. Omfanget af økonomisk og kognitiv kapital i opvækstmiljøet synes ikke at spille...

What's the frequency, Kenneth? – Eine (queerfeministische Kritik an Sexismen und Rassismen im Schlagwortkatalog

Directory of Open Access Journals (Sweden)

Sandra Sparber

2016-09-01

Full Text Available Sprachliche Diskriminierungen bilden sich auf verschiedenen Ebenen im Schlagwortkatalog ab. In unterschiedlichen Ausprägungen finden wir sie sowohl in den Normdaten als auch in der Schlagwortfolge. Ziel des Aufsatzes ist es, die bibliothekarische Inhaltserschließung als soziale Praxis in einen theoretischen Bezugsrahmen einzubetten, um sie einer fundierten Kritik zugänglich zu machen.

Vi er nødt til at skelne mellem prostitution og gaveøkonomi

DEFF Research Database (Denmark)

Groes, Christian

2017-01-01

En dokumentarserie på DR3 følger en ung sugardater, hvilket har ført til en del debat om fænomenet gråzoneprostitution. Både mænd og kvinder der benytter sig af sugardating er nødt til at være bevidste om, hvad de bevæger sig ud i....

Effektmåling af ”Sikker Trafik Live” – delrapport 1

DEFF Research Database (Denmark)

Hansen, Helle; Sandoy, Tróndur Møller; Kristensen, Christian Li

Trafikulykker er en af de hyppigste dødsårsager blandt unge under 25 år, og i omkring hver femte alvorlige ulykke er en 15-24-årig involveret. For at bryde denne statistik tilbyder Rådet for Sikker Trafik i samarbejde med TrygFonden undervisningsindsatsen ”Sikker Trafik LIVE”, der er et foredrag ...

Cas clin La dysp et Enfa nique, Volu plasie ecto nt de la Fo ume 4 ...

African Journals Online (AJOL)

Raoul

tic diseases c case of a you bnormalities dysplasia wa diagnosis. D and have a b mique, anhy. 10 otique : à iya, Yaoun nebenimp F. BIYA, Yaoun. Cameroun; † ation Chantal characterized ung boy seen of the teeth as discussed. Dental prosth better self ima ydrotique,hypo. Page n. PDF prov. Publié le propos d' ndé, Came.

Produktudvikling og afsætningsøkonomisk forskning: Hvad har det med hinanden at gøre?

DEFF Research Database (Denmark)

Harmsen, Hanne

2000-01-01

Lad det være sagt med det samme. Produktudvikling er ikke et afsætningsøkonomisk kerneområde, hverken forsknings- eller undervisningsmæssigt på samme måde som eksempelvis forbrugeradfærd, reklameforskning eller industriel købsadfærd. Det skyldes blandt andet, at det er en ung forskningsretning, der...

Evaluering af lokale udviklingsprocesser

DEFF Research Database (Denmark)

Jensen, Bente

Rapporten udgør arbejdspapir nr 14 i forskningsprojektet "Handlekompetence i pædagogiske arbejde med socialt udsatte børn og unge - indsats og effekt (HPA-projektet). Rapporten diskuterer det grundlæggende spørgsmål: Hvad er evaluering? Herunder spørgsmål om hvilke dimensioner der skal medtænkes ...

Achenbachs child behavior checklist CBCL og relaterede instrumenter

DEFF Research Database (Denmark)

Nissen, Poul Erik

Achenbachs empiribaserede assessmentsystem (ASEBA) består af en række spørgeskemaer, som er udviklede med henblik på vurdering af et bredt spektrum af problemfelter og kompetencer hos børn, unge og voksne lige fra 1½ års alderen til 90+.Det er et såkaldt multiinformant system, hvor hovedparten af...

Discovery of Emerging Per-and Polyfluoroalkyl Substances

Science.gov (United States)

Legacy perfluorinated compounds exhibit significant environmental persistence and bioaccumulation potential, which has spawned an ongoing effort to introduce replacement compounds with reduced toxicological risk profiles. Many of these emerging chemical species lack validated qua...

Conveyor belt nuclear weighing machine

International Nuclear Information System (INIS)

Anon.

1977-01-01

In many industries the flow of materials on conveyor belts must be measured and controlled. Electromechanical weighing devices have high accuracy but are complicated and expensive to install and maintain. For many applications the nuclear weighing machine has sufficient accuracy but is considerably simpler, cheaper and more robust and is easier to maintain. The rating and performance of a gamma ray balance on the mar ket are detailed. (P.G.R.)

Browse Author Index

African Journals Online (AJOL)

Items 9251 - 9300 of 10152 ... van Huyssteen, G.J. · van Iddekinge, B · Van Iddekinge, B. van Iddekinge, Basil · van Jaarsveld, A · van Jaarsveld, H. van Jaarsveld, J · van Jaarsveld, P.P. · van Jaarsveld, Paul J · Van Kets, V · van Lathem, Johanna M. van Leenhoff, JW · van Lente, Jan · van Lierde, S. van Lierop, A C · van Lierop ...

Maternal Personality, Parenting Cognitions and Parenting Practices

Science.gov (United States)

Bornstein, Marc H.; Hahn, Chun-Shin; Haynes, O. Maurice

2011-01-01

A community sample of 262 European American mothers of firstborn 20-month-olds completed a personality inventory and measures of parenting cognitions (knowledge, self-perceptions, and reports about behavior) and was observed in interaction with their children from which measures of parenting practices (language, sensitivity, affection, and play) were independently coded. Factor analyses of the personality inventory replicated extraction of the Five-Factor model of personality (Openness, Neuroticism, Extraversion, Agreeableness, and Conscientiousness). Controlling for sociodemographic characteristics, the five personality factors qua variables and in patterns qua clusters related differently to diverse parenting cognitions and practices, supporting the multidimensional, modular, and specific nature of parenting. Maternal personality in the normal range, a theoretically important but empirically neglected factor in everyday parenting, has meaning in studies of parenting, child development, and family process. PMID:21443335

Computational fluid dynamics in greenhouses: A review

African Journals Online (AJOL)

use

2011-12-05

Dec 5, 2011 ... reduce environmental impact while enhancing crop qua- lity and yields .... within a mild climate, appropriate design and control of ventilation are required .... crucial parameter in the pattern of internal greenhouse temperatures ...

A Framework for Evaluating Energy and Emissions of Connected and Automated Vehicles through Traffic Microsimulations

Science.gov (United States)

2018-01-07

Connected and automated vehicles (CAV) are poised to transform surface transportation systems in the United States. Near-term CAV technologies like cooperative adaptive cruise control (CACC) have the potential to deliver energy efficiency and air qua...

Evaluation of the Effects of Ketoconazole and Voriconazole on the Pharmacokinetics of Oxcarbazepine and Its Main Metabolite MHD in Rats by UPLC-MS-MS.

Science.gov (United States)

Chen, Xinxin; Gu, Ermin; Wang, Shuanghu; Zheng, Xiang; Chen, Mengchun; Wang, Li; Hu, Guoxin; Cai, Jian-ping; Zhou, Hongyu

2016-03-01

Oxcarbazepine (OXC), a second-generation antiepileptic drug, undergoes rapid reduction with formation of the active metabolite 10,11-dihydro-10-hydroxy-carbazepine (MHD) in vivo. In this study, a method for simultaneous determination of OXC and MHD in rat plasma using ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS-MS) was developed and validated. Under given chromatographic conditions, OXC, MHD and internal standard diazepam were separated well and quantified by electrospray positive ionization mass spectrometry in the multiple reaction monitoring transitions mode. The method validation demonstrated good linearity over the range of 10-2,000 ng/mL for OXC and 5-1,000 ng/mL for MHD. The lower limit of quantification was 5 ng/mL for OXC and 2.5 ng/mL for MHD, respectively. The method was successfully applied to the evaluation of the pharmacokinetics of OXC and MHD in rats, with or without pretreatment by ketoconazole (KET) and voriconazole (VOR). Statistics indicated that KET and VOR significantly affected the disposition of OXC and MHD in vivo, whereas VOR predominantly interfered with the disposition of MHD. This method is suitable for pharmacokinetic study in small animals. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis

Directory of Open Access Journals (Sweden)

Rodrigo Almeida-Paes

Full Text Available BACKGROUND Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs are available. In this situation, minimal inhibitory concentration (MIC distributions and epidemiological cutoff values (ECVs support the detection of identification of resistant strains. OBJECTIVES To study the MIC distributions of five antifungal drugs against S. brasiliensis and to propose tentative ECVs. METHODS MICs of amphotericin B (AMB, itraconazole (ITR, ketoconazole (KET, posaconazole (POS, and terbinafine (TRB against 335 S. brasiliensis strains were determined by the Clinical and Laboratory Standards Institute broth microdilution method. FINDINGS The proposed ECV, in µg/mL, for AMB, ITR, KET, POS, and TRB were 4.0, 2.0, 1.0, 2.0, and 0.25, respectively. Percentages of wild-type strains in our population for the above antifungal drugs were 98.48, 95.22, 95.33, 100, and 97.67%, respectively. MAIN CONCLUSIONS These ECVs will be useful to detect strains with resistance, to define CBPs, and to elaborate specific therapeutic guidelines for S. brasiliensis. Rational use of antifungals is strongly recommended to avoid the emergence of resistant strains and ensure the therapeutic effectiveness of sporotrichosis.

Science-Economy-Technology Concordance Matrix for Development and Implementation of Regional Smart Specializations in the Silesian Voivodeship, Poland

Directory of Open Access Journals (Sweden)

Adam Smoliński

2015-01-01

Full Text Available The regional smart specializations include the innovative activities within a common science-economy-technology sector, which open the opportunities to gain a competitive advantage. The original procedure of science-economy-technology concordance matrix development on an example of smart specializations of the Silesian Voivodeship was presented in the paper. The procedure developed includes recognition of the research and economic components of the regional smart specialization and the connection between the economic components of the regional specialization and the technological innovation through the international patent classification. It also comprises recognition of key enabling technologies (KETs and high technologies (of high R&D intensity other than KET in the economic and technological dimensions of innovation as well as the high R&D intensity services in the economic dimension of innovation. The in-depth expert analyses with the application of the Delphi method were also taken into account. The methodological approach developed and the visualization method applied are both of cognitive and practical importance since they contribute significantly to the creation of efficient development policies, to the enhancement and facilitation of cross-sectoral cooperation, and to the focusing on the fields of key importance in terms of the competitive advantage of a region.

Science-Economy-Technology Concordance Matrix for Development and Implementation of Regional Smart Specializations in the Silesian Voivodeship, Poland.

Science.gov (United States)

Smoliński, Adam; Bondaruk, Jan; Pichlak, Magdalena; Trząski, Leszek; Uszok, Elżbieta

2015-01-01

The regional smart specializations include the innovative activities within a common science-economy-technology sector, which open the opportunities to gain a competitive advantage. The original procedure of science-economy-technology concordance matrix development on an example of smart specializations of the Silesian Voivodeship was presented in the paper. The procedure developed includes recognition of the research and economic components of the regional smart specialization and the connection between the economic components of the regional specialization and the technological innovation through the international patent classification. It also comprises recognition of key enabling technologies (KETs) and high technologies (of high R&D intensity) other than KET in the economic and technological dimensions of innovation as well as the high R&D intensity services in the economic dimension of innovation. The in-depth expert analyses with the application of the Delphi method were also taken into account. The methodological approach developed and the visualization method applied are both of cognitive and practical importance since they contribute significantly to the creation of efficient development policies, to the enhancement and facilitation of cross-sectoral cooperation, and to the focusing on the fields of key importance in terms of the competitive advantage of a region.

Measurement of the higher-order anisotropic flow coefficients for identified hadrons in Au + Au collisions at √{sN N}=200 GeV

Science.gov (United States)

Adare, A.; Afanasiev, S.; Aidala, C.; Ajitanand, N. N.; Akiba, Y.; Al-Bataineh, H.; Alexander, J.; Aoki, K.; Aramaki, Y.; Atomssa, E. T.; Averbeck, R.; Awes, T. C.; Azmoun, B.; Babintsev, V.; Bai, M.; Baksay, G.; Baksay, L.; Barish, K. N.; Bassalleck, B.; Basye, A. T.; Bathe, S.; Baublis, V.; Baumann, C.; Bazilevsky, A.; Belikov, S.; Belmont, R.; Bennett, R.; Berdnikov, A.; Berdnikov, Y.; Bickley, A. A.; Bok, J. S.; Boyle, K.; Brooks, M. L.; Buesching, H.; Bumazhnov, V.; Bunce, G.; Butsyk, S.; Camacho, C. M.; Campbell, S.; Chen, C.-H.; Chi, C. Y.; Chiu, M.; Choi, I. J.; Choudhury, R. K.; Christiansen, P.; Chujo, T.; Chung, P.; Chvala, O.; Cianciolo, V.; Citron, Z.; Cole, B. A.; Connors, M.; Constantin, P.; Csanád, M.; Csörgő, T.; Dahms, T.; Dairaku, S.; Danchev, I.; Das, K.; Datta, A.; David, G.; Denisov, A.; Deshpande, A.; Desmond, E. J.; Dietzsch, O.; Dion, A.; Donadelli, M.; Drapier, O.; Drees, A.; Drees, K. A.; Durham, J. M.; Durum, A.; Dutta, D.; Edwards, S.; Efremenko, Y. V.; Ellinghaus, F.; Engelmore, T.; Enokizono, A.; En'yo, H.; Esumi, S.; Fadem, B.; Fields, D. E.; Finger, M.; Finger, M.; Fleuret, F.; Fokin, S. L.; Fraenkel, Z.; Frantz, J. E.; Franz, A.; Frawley, A. D.; Fujiwara, K.; Fukao, Y.; Fusayasu, T.; Garishvili, I.; Glenn, A.; Gong, H.; Gonin, M.; Goto, Y.; Granier de Cassagnac, R.; Grau, N.; Greene, S. V.; Grosse Perdekamp, M.; Gu, Y.; Gunji, T.; Gustafsson, H.-Å.; Haggerty, J. S.; Hahn, K. I.; Hamagaki, H.; Hamblen, J.; Han, R.; Hanks, J.; Hartouni, E. P.; Haslum, E.; Hayano, R.; He, X.; Heffner, M.; Hemmick, T. K.; Hester, T.; Hill, J. C.; Hohlmann, M.; Holzmann, W.; Homma, K.; Hong, B.; Horaguchi, T.; Hornback, D.; Huang, S.; Ichihara, T.; Ichimiya, R.; Ide, J.; Ikeda, Y.; Imai, K.; Inaba, M.; Isenhower, D.; Ishihara, M.; Isobe, T.; Issah, M.; Isupov, A.; Ivanischev, D.; Jacak, B. V.; Jia, J.; Jin, J.; Johnson, B. M.; Joo, K. S.; Jouan, D.; Jumper, D. S.; Kajihara, F.; Kametani, S.; Kamihara, N.; Kamin, J.; Kang, J. H.; Kapustinsky, J.; Karatsu, K.; Kawall, D.; Kawashima, M.; Kazantsev, A. V.; Kempel, T.; Khanzadeev, A.; Kijima, K. M.; Kim, B. I.; Kim, D. H.; Kim, D. J.; Kim, E.; Kim, E.-J.; Kim, S. H.; Kim, Y.-J.; Kinney, E.; Kiriluk, K.; Kiss, Á.; Kistenev, E.; Kochenda, L.; Komkov, B.; Konno, M.; Koster, J.; Kotchetkov, D.; Kozlov, A.; Král, A.; Kravitz, A.; Kunde, G. J.; Kurita, K.; Kurosawa, M.; Kwon, Y.; Kyle, G. S.; Lacey, R.; Lai, Y. S.; Lajoie, J. G.; Lebedev, A.; Lee, D. M.; Lee, J.; Lee, K.; Lee, K. B.; Lee, K. S.; Leitch, M. J.; Leite, M. A. L.; Leitner, E.; Lenzi, B.; Li, X.; Liebing, P.; Linden Levy, L. A.; Liška, T.; Litvinenko, A.; Liu, H.; Liu, M. X.; Love, B.; Luechtenborg, R.; Lynch, D.; Maguire, C. F.; Makdisi, Y. I.; Malakhov, A.; Malik, M. D.; Manko, V. I.; Mannel, E.; Mao, Y.; Masui, H.; Matathias, F.; McCumber, M.; McGaughey, P. L.; Means, N.; Meredith, B.; Miake, Y.; Mignerey, A. C.; Mikeš, P.; Miki, K.; Milov, A.; Mishra, M.; Mitchell, J. T.; Mizuno, S.; Mohanty, A. K.; Morino, Y.; Morreale, A.; Morrison, D. P.; Moukhanova, T. V.; Murata, J.; Nagamiya, S.; Nagle, J. L.; Naglis, M.; Nagy, M. I.; Nakagawa, I.; Nakamiya, Y.; Nakamura, T.; Nakano, K.; Newby, J.; Nguyen, M.; Niida, T.; Nouicer, R.; Nyanin, A. S.; O'Brien, E.; Oda, S. X.; Ogilvie, C. A.; Oka, M.; Okada, K.; Onuki, Y.; Oskarsson, A.; Ouchida, M.; Ozawa, K.; Pak, R.; Pantuev, V.; Papavassiliou, V.; Park, I. H.; Park, J.; Park, S. K.; Park, W. J.; Pate, S. F.; Pei, H.; Peng, J.-C.; Pereira, H.; Peresedov, V.; Peressounko, D. Yu.; Pinkenburg, C.; Pisani, R. P.; Proissl, M.; Purschke, M. L.; Purwar, A. K.; Qu, H.; Rak, J.; Rakotozafindrabe, A.; Ravinovich, I.; Read, K. F.; Reygers, K.; Reynolds, D.; Riabov, V.; Riabov, Y.; Richardson, E.; Roach, D.; Roche, G.; Rolnick, S. D.; Rosati, M.; Rosen, C. A.; Rosendahl, S. S. E.; Rosnet, P.; Rukoyatkin, P.; Ružička, P.; Sahlmueller, B.; Saito, N.; Sakaguchi, T.; Sakashita, K.; Samsonov, V.; Sano, S.; Sato, T.; Sawada, S.; Sedgwick, K.; Seele, J.; Seidl, R.; Semenov, A. Yu.; Seto, R.; Sharma, D.; Shein, I.; Shibata, T.-A.; Shigaki, K.; Shimomura, M.; Shoji, K.; Shukla, P.; Sickles, A.; Silva, C. L.; Silvermyr, D.; Silvestre, C.; Sim, K. S.; Singh, B. K.; Singh, C. P.; Singh, V.; Slunečka, M.; Soltz, R. A.; Sondheim, W. E.; Sorensen, S. P.; Sourikova, I. V.; Sparks, N. A.; Stankus, P. W.; Stenlund, E.; Stoll, S. P.; Sugitate, T.; Sukhanov, A.; Sziklai, J.; Takagui, E. M.; Taketani, A.; Tanabe, R.; Tanaka, Y.; Tanida, K.; Tannenbaum, M. J.; Tarafdar, S.; Taranenko, A.; Tarján, P.; Themann, H.; Thomas, T. L.; Todoroki, T.; Togawa, M.; Toia, A.; Tomášek, L.; Torii, H.; Towell, R. S.; Tserruya, I.; Tsuchimoto, Y.; Vale, C.; Valle, H.; van Hecke, H. W.; Vazquez-Zambrano, E.; Veicht, A.; Velkovska, J.; Vértesi, R.; Vinogradov, A. A.; Virius, M.; Vrba, V.; Vznuzdaev, E.; Wang, X. R.; Watanabe, D.; Watanabe, K.; Watanabe, Y.; Wei, F.; Wei, R.; Wessels, J.; White, S. N.; Winter, D.; Wood, J. P.; Woody, C. L.; Wright, R. M.; Wysocki, M.; Xie, W.; Yamaguchi, Y. L.; Yamaura, K.; Yang, R.; Yanovich, A.; Ying, J.; Yokkaichi, S.; You, Z.; Young, G. R.; Younus, I.; Yushmanov, I. E.; Zajc, W. A.; Zhang, C.; Zhou, S.; Zolin, L.; Phenix Collaboration

2016-05-01

Measurements of the anisotropic flow coefficients v2{Ψ2} ,v3{Ψ3} ,v4{Ψ4} , and v4{Ψ2} for identified particles (π±,K± , and p +p ¯ ) at midrapidity, obtained relative to the event planes Ψm at forward rapidities in Au + Au collisions at √{sNN}=200 GeV , are presented as a function of collision centrality and particle transverse momenta pT. The vn coefficients show characteristic patterns consistent with hydrodynamical expansion of the matter produced in the collisions. For each harmonic n , a modified valence quark-number Nq scaling [plotting vn{Ψm} /(Nq) n /2 versus transverse kinetic energies (KET) /Nq] is observed to yield a single curve for all the measured particle species for a broad range of KET. A simultaneous blast-wave model fit to the observed vn{Ψm} (pT) coefficients and published particle spectra identifies radial flow anisotropies ρn{Ψm} and spatial eccentricities sn{Ψm} at freeze-out. These are generally smaller than the initial-state participant-plane geometric eccentricities ɛn{ΨmPP} as also observed in the final eccentricity from quantum interferometry measurements with respect to the event plane.

Untitled

African Journals Online (AJOL)

MAK

its enabling capacity to fulfil personal and social aspirations (Ahmed, 1979: 109). ... Methodist, Baptist, Presbyterian, and Qua Iboe, elementary schools were ... radio media in education which started in the early 1940s and mid1950s. The.

Water quality mitigation banking : final report, December 2009.

Science.gov (United States)

2009-12-01

Current practice in New Jersey for mitigating stormwater impacts caused by transportation infrastructure : projects is established by NJDEP Stormwater Regulations (N.J.A.C. 7:8). These rules outline specific : processes to offset impacts to water qua...

Performance-Based Risk-Sharing Arrangements: U.S. Payer Experience.

Science.gov (United States)

Goble, Joseph A; Ung, Brian; van Boemmel-Wegmann, Sascha; Navarro, Robert P; Parece, Andrew

2017-10-01

modeling ranked highest among methods of manufacturer facilitation of PBRSAs. This study was limited by sample size and survey questions were limited to explanation of PBRSAs at the disease state level. On the basis of PBRSA experiences, respondents noted that drug use in chronic medical conditions and objective drug outcome performance measurements were favorable drug characteristics and serve as the primary source of satisfaction for these types of contracts. Third parties and manufacturers can facilitate the uptake and success of PBRSAs by developing standardized contracting templates in addition to other methods that increase their stake in the arrangement. Looking forward, mounting perceptions of success in this realm of contracting for pharmaceuticals may contribute in the quest for value-based payments in the U.S. health care system. The construction of the survey and payment for survey respondents were supported by Charles River Associates. Parece is an employee of Charles River Associates. Goble and Ung are completing fellowship training sponsored by Novartis and Celgene, respectively, but do not have any conflicts of interest and did not receive any funding related to this study. Navarro reports consulting fees from Analysis Group, TEVA, and Amgen, unrelated to this study. Van Boemmel-Wegmann declares no conflict of interest. Study concept and design were contributed by Navarro, Goble, Ung, and Parece. Navarro took the lead in data collection, along with Goble and Ung, and data interpretation was performed by van Boemmel-Wegmann, Goble, and Ung. The manuscript was written by Goble, Ung, Navarro, and van Boemmel-Wegmann and revised by all of the authors.

Magt, sex og klassehad

DEFF Research Database (Denmark)

Böss, Michael

2009-01-01

At kirkens magt i Irland antog en så pervers karakter, skyldtes bl.a., at den var blevet overgivet en samfundsklasse, som ikke havde været vant til at udøve magt, dengangIrland var en del af Det Forenede Kongerige. Artilens anledning er udgivelsen af en rapport i Irland om mosbruig af børn og ung...

4 år efter grundskolen

DEFF Research Database (Denmark)

Andersen, Dines

begynde at kaste nyt lys over hvorfor-spørgsmålene. Denne rapport beskæftiger sig med unge 4 år efter grundskolen. Hvor langt er de kommet i deres uddannelsesforløb? Og hvordan kan vi forklare deres placering på dette tidspunkt? Nogle er tilsyneladende ingen veje kommet. De tilhører den uddannelsesmæssige...

Mental sundhed i skolen

DEFF Research Database (Denmark)

Wistoft, Karen; Grabowski, Dan

Denne rapport sætter fokus på børn og unges mentale sundhed. Skolen kan gøre en forskel ved at skabe rammerne for en mental sundhedsfremmende skole, der tænker sundhedsbegrebet bredt. Men skolen bør ikke stå alene med ansvaret og derfor er der behov for en samlet strategi. En mentalt sundhedsfrem...

Et dansk regime for overgang fra uddannelse til arbejde?

DEFF Research Database (Denmark)

Jørgensen, Christian Helms

2008-01-01

I dette kapitel vil jeg først gennemgå en række forskningstilgange som på forskellig måde kan begribe de særlige træk ved unges overgang i Danmark i det man kan kalde et dansk 'regime for overgang' (transition regime). Dernæst følger en mere beskrivende gennemgang af det danske uddannelsessystem ...

Forberedende tilbud og overgang til ungdomsuddannelse

DEFF Research Database (Denmark)

Rangvid, Beatrice Schindler; Jensen, Vibeke Myrup; Nielsen, Sarah Sander

rapport. En af hovedkonklusionerne er, at det – med det nuværende system – ikke umiddelbart vil have en positiv effekt at udvide ordningen. I hvert fald ikke, hvis målet er at give ikke-uddannelsesparate unge den ballast, de mangler for at påbegynde og gennemføre en ungdomsuddannelse. Der er dog tegn på...

jeg Q godt hvis D var D jeg ville

DEFF Research Database (Denmark)

Toft, Herdis

2003-01-01

Skolen har hidtil set det som sin opgave at standardisere børnenes sprog- og mediebrug. Men mellem unges sms-sprog og præmoderne skrifttyper er der væsentlige fællestræk. Børn har desuden et andet og vandrende blik for relationen teknik og æstetik. De er optaget af kommunikationens formmæssige as...

Dynamisk assessment som interventionsværktøj

DEFF Research Database (Denmark)

Eiberg, Misja; Andersen, Luna Kragh; Scavenius Sonne-Schmidt, Christoffer

Anbragte børn og unge klarer sig markant dårligere skolemæssigt end deres ikke-anbragte jævnaldrende. Ligeledes kan en sårbar opvækst i den tidlige barndom have negativ indflydelse på bl.a. børnenes kognitive udvikling og betyde, at de kan opleve indlæringsmæssige udfordringer i skolen siden hen....

Organisationsprobleme im Ökomarketing

OpenAIRE

Dienel, Wolfram

2000-01-01

Organisationsprobleme im Ökomarketing - eine transaktionskostentheoretische Analyse im Absatzkanal konventioneller Lebensmittelhandel Die im Vergleich zum großen Nachfragepotential zögerliche Entwicklung des Ökomarkts in Deutschland ist auf Organisationsprobleme zurückzuführen. Die Organisationsprobleme behindern insbesondere die großskalige Ökomarkterschließung über die konventionellen Supermarktketten, erschweren aber auch die Effizienzsteigerung im kleiner strukturierten alternativen N...

Fri os fra FOMO

DEFF Research Database (Denmark)

Andersen, Tem Frank

2013-01-01

Danske unge brugte i 2012 godt 9.000.000 timer i snit om måneden på at interagere med sociale medier. De ”unge” voksne brugte godt 6.500.000 timer i snit. Det er tal, som er rigtigt interessante for dem, der lever af tid, fordi brugerens opmærksomhed er yderst værdifuld. Marketingsfolk og andre l...

Moving vortices in noncommutative gauge theory

International Nuclear Information System (INIS)

Horvathy, P.A.; Stichel, P.C.

2004-01-01

Exact time-dependent solutions of nonrelativistic noncommutative Chern-Simons gauge theory are presented in closed analytic form. They are different from (indeed orthogonal to) those discussed recently by Hadasz, Lindstroem, Rocek and von Unge. Unlike theirs, our solutions can move with an arbitrary constant velocity, and can be obtained from the previously known static solutions by the recently found 'exotic' boost symmetry

Stærke kvinder uden duft

DEFF Research Database (Denmark)

Andersen, Tem Frank

2013-01-01

Kulturhistoriske kan vi finde flere eksempler på renselsesritualer, hvor man søger at vaske ”det urene” væk, eller fjerne den mistænkelige stank af ondskab. Den unge kvinde i reklamen er præcist i gang med et af vore moderne renselsesritualer: Fitness! Gennem kropslig bevægelse søger vi at fjerne...

Systemisk og narrativ familieteori

DEFF Research Database (Denmark)

Rasmussen, Svend Aage

2010-01-01

Spiseforstyrrelser som anoreksi og bulimi har op gennem det 20. århundrede og især inden for de sidste 50 år været et stigende problem i den vestlige verden. Problemet er særlig udbredt blandt unge kvinder, der står på tærsklen til voksenverdenen, og har store omkostninger af såvel psykologisk som...

Når pansret falder bliver der plads til forandring gennem kroppen og fællesskabet

DEFF Research Database (Denmark)

Hviid, Sofie; Clausen, Lone Maj Sand; Mørck, Line Lerche

2017-01-01

Hvis man skal forandre sit liv så drastisk, som det er tilfældet for unge mænd med kriminel baggrund, der vil en anden tilværelse, skal der skrues på rigtig mange parametre. Opskriften er langt fra statisk, og hvad der virker for den ene, virker ikke for den anden. Men mange har med succes forand...

Er idrætslæreren ved at få en ny innovativ rolle?

DEFF Research Database (Denmark)

Elbæk, Lars

2012-01-01

Sedentarismen – stillesiddende aktivitet – har nu også ramt børn og unge. Det kan derfor meget nemt opfattes som et paradoks, at vi netop nu laver et temanummer om IT og idræt. Ikke desto mindre findes der efterhånden mange gadgets og apps, som kan bruges i forbindelse med idræt og fysisk aktivit...

Træk af en ung Karl Marx

DEFF Research Database (Denmark)

Ziegler, Magnus Møller

2018-01-01

Det kritiske program, som var Karl Marx' bidrag til både tænkningen og den revolutionære bevægelse, tog sit udgangspunkt i det filosofiske miljø, der dominerede i Tyskland i 1840'erne.......Det kritiske program, som var Karl Marx' bidrag til både tænkningen og den revolutionære bevægelse, tog sit udgangspunkt i det filosofiske miljø, der dominerede i Tyskland i 1840'erne....

Unge voksne på Tinder : en kvalitativ studie

OpenAIRE

Ottesen, Mathilde Dagsvik

2015-01-01

Denne studien undersøker Tinder som arena for selvpresentasjon. Gjennom kvalitative intervjuer med syv studenter mellom 20 og 30 år, har jeg søkt svar på hvordan en presenterer seg selv på Tinder, hvordan en vurderer andre brukeres selvpresentasjon, samt implikasjoner av Tinder. I samsvar med Bourdieu (1986), undersøker jeg Tinder som et sosi...

Rulasõidu evolutsioon linnadžunglis / Ats Luik

Index Scriptorium Estoniae

Luik, Ats

2011-01-01

2.- 4. veebr. kinos Artis toimuvast Simpel Session 11 rula- ja rattafilmide festivalist. 3. veebruaril saab näha Coan Nicholsi ja Rick Charnoski filmi "Deathbowl to Downtown - The Evolution of Skateboarding in New York City" (USA 2010)

Unge og looping-effekten af computerspilafhængighed

DEFF Research Database (Denmark)

Brus, Anne

2015-01-01

In this article I set out to investigate the social construction of computer game addiction in young people’s everyday life. On the basis of qualitative interviews with three Danish teenage boys the article analyses how worries of computer game addiction is being produced and reproduced in social...... situations as well as how young people adapt to and resist the classification of computer game addiction. On the one hand the young people adapt the classification in order to get control of their gaming. On the other hand there is a risk of pathologization as their conduct may be linked to adaptive...

MARKET WATCH

Institute of Scientific and Technical Information of China (English)

2007-01-01

TO THE POINT: The Chinese central bank raised the interest rate for the fifth time this year but this had little impact on the property and stock mar- kets. Foreign direct investment and fixed asset investment saw moderate increases in the first eight months, partly because of the government’s tightening policies. Gold futures will be traded on the market. Online traders are now required to acquire business licenses from regulative bodies.

Regionalizing East Mediterranean Gas: Energy Security, Stability, and the U.S. Role

Science.gov (United States)

2014-12-01

Lebanon to supply LNG to Europe, Latin America , or even Asia appears politically attrac- tive both on a domestic and regional level. LNG mar- kets such...exploration costs and low oil prices, but the reality includes probably poor seismic data and high resultant investment risk , coupled with ex...EL-KATIRI is a Director of MENA In- sight, a political risk consultancy that focuses on the Middle East and North Africa, and a Senior Research

Projekt objektu dřevostavby

OpenAIRE

Václavek, Lukáš

2015-01-01

This thesis deals with drafting a residential building wood based on existing supermar-ket which is located on a plot placement - concealed in the village Omice. According to the location of the parcel has been designed layout and shape solutions objectively. The next step was to propose design solutions and their compositions with the assessed thermal solution. Peripheral construction of residential house was assessed according to ČSN 730540 proposed residential building study documentation ...

The comparative impact of lexical translation and lexical inferencing on EFL learners’ vocabulary retention

OpenAIRE

Nasim Shangarfam; Neda Ghorbani; Ehsan Safarpoor; Mahshid Maha

2013-01-01

The present study is an attempt to investigate the comparative effects of lexical translation and lexical inferencing techniques on Female intermediate EFL learners’ vocabulary retention. For this purpose, 90 female learners attending the Jahad Daneshgahi Center in Qom took a piloted sample KET test, 60 of whom were selected as homogenous learners. They were randomly divided into two experimental groups-one learning new vocabulary items through lexical translation technique and the other with...

3.-11. XI oli Edinburghi ECA Sculpture Court Balcony'l...

Index Scriptorium Estoniae

2005-01-01

Eesti päevade raames Kristi Paabi ja Maria Valdma kureeritud näitus "Rare Leid". Osalesid Kristiina Laurits, Villu Plink, Kaire Rannik, Mari Relo-Shaulys, Adolfas Shaulys, Anneli Tammik, Ketli Tiitsar ja Tanel Veenre. 3. XI ehtekunsti sümpoosionil Edinburghi kunstikolledzhis College of Artis esinesid loengutega Birgit Laken (Holland), K. Tiitsar ja T. Veenre. K. Paap ja M. Valdma juhendasid töötuba "Triibud või ruudud" ehtekunsti üliõpilastele

Herrens röst

DEFF Research Database (Denmark)

Rösing, Lilian Munk

2015-01-01

Om språket är gränsen mellan djur och människor, vad innebär det när hundar talar? I filmen Upp pratar de animerade hundarna, men med sin husses röst. Lilian Munk Rösing ser filmen i sällskap av bland andra Jacques Lacan, Slavoj Žižek och Renata Salecl och finner en röst utan kropp, en kropp besj...

Preparation and stability study of ampouled polycyclic aromatic hydrocarbon solutions

NARCIS (Netherlands)

Vaessen; H.A.M.G.; Kamp; C.G. van de; Jekel; A.A.

1986-01-01

De stabiliteit van geampulleerde acetonitril- en tolueenoplossingen van zeven polycyclische aromatische koolwaterstoffen (PAK) werd bestudeerd gedurende een jaar. Beide oplossingen waren qua PAK- samenstelling en gehalte identiek en bereid uit een moederoplossing. Voor en vlak na het ampulleren

Ehte järelkasv ja klassikud laegast täitmas / Ketli Tiitsar

Index Scriptorium Estoniae

Tiitsar, Ketli

2004-01-01

Ede Kurreli 95. sünniaastapäevale pühendatud Eesti Metallikunstnike Liidu ja Eesti Kunstiakadeemia ehte- ja sepakunsti eriala ühisnäitus "Laegas" Eesti Tarbekunsti- ja Disainimuuseumis kuni 17. X. Ede Kurreli, Arseni Möldri, Leili Kuldkepi, Kadri Mälgu, rühmituse ÕhuLoss, Birgit Marjundi, Risto Tali, Bruno Lillemetsa, Tõnis Bergi, Mart Reino, Adolfas Shaulyse, Mari Relo-Shaulyse, parima üliõpilastöö autori Kertu Tubergi ja 2004. a. Ede Kurreli preemia saanud Anneli Tammiku töödest, Maria Puki ja Ivar Lubjaku näitusekujundusest

Kas praegune triennaal õnnestus? : tarbekunst / Ketli Tiitsar ; interv. R[eet] V[arblane

Index Scriptorium Estoniae

Tiitsar, Ketli

2006-01-01

Tallinna IV rakenduskunsti triennaali töögrupi liige K. Tiitsar triennaalist, näituse kujundusest (3+1 Arhitektid), eesti tarbekunstist, seminarist ja esitluste päevast (Mecky van den Brinki, Heli Hietala, Marie-Louise Kristenseni, Outi Liusvaara esinemine), satelliitnäitustest (Anneli Porri ja Pille-Triin Männiku kuraatoriprojekt "Teadus ja tänapäev", Hollandi Gerrit Rietveldi akadeemia ehteosakonna üliõpilaste tööde näitus EKA galeriis)

From The Sea Wall to The Lover : Prostitution and Exotic Parody

Directory of Open Access Journals (Sweden)

Pascale Bécel

1997-06-01

Full Text Available This analysis of the two novels highlights Marguerite Duras' equivocal stance with regard to colonial Indochina where she grew up at the beginning of the century. As The Lover rewrites The Sea Wall in the autobiographical mode, the emphasis shifts from an explicit denunciation of colonialism and an implicit subversion of the Lotilian novel, to a parody of exotic themes and narratives. However, by focusing on the two young protagonists' construction of themselves as femmes fatales and prostitutes, this discussion reveals that the politics of gender and race remain at odds in Duras' fictional autobiographies. The cultural other (qua a passive indigenous population in The Sea Wall , qua eroticized oriental[ized] bodies in The Lover remains a measure of the protagonist's construction as a female subject; a measure, in Chandra Mohanty's words, of the "liberated" western woman's "discursive self-presentation."

Cine Qua Non: The Political Import and Impact of The Battle of Algiers Cine Qua Non : L’impact de La bataille d’Alger

Directory of Open Access Journals (Sweden)

Stephen J. Whitfield

2012-03-01

Full Text Available Co-production italo-algérienne (en français et en arabe, La Battaglia di Algeri (1965, mérite le titre de meilleur film jamais réalisé. Gillo Pontecorvo, réalisateur et co-scénariste, montre avec brio et perspicacité les luttes de groupes d’insurgés se livrant à une guérilla urbaine dans l’Alger des années 1954-1957. Dans son portrait des exactions terroristes, ce film anticipe une vision du monde actuel, empli d’une violence effroyable, insoutenable. Ce film prémonitoire a un impact indéniable sur le temps présent. Que l’on soit de gauche ou de droite, de 1965 à nos jours, ce film ne cesse de fasciner. Ainsi dans le cadre de cette étude, je tenterai de mettre en relief la réalité historique à travers l’art cinématographique. Censuré en France en 1965, et peu projeté en salle dans la décennie qui suivit, ce film garde de sa force impressionnante grâce à son style étonnant mais aussi au thème choisi, criant par son éternelle actualité.

Decentralized Planning for Pre-Conflict and Post-Conflict ...

African Journals Online (AJOL)

2012-10-02

Oct 2, 2012 ... Such processes are 'sine qua non' to pre-conflict and post-conflict prevention. .... A Basic Approach to Pre-Conflict Management Planning ... and also factor in an evaluation of perception variables that help us to understand ...

Mental sundhed i skolen

DEFF Research Database (Denmark)

Wistoft, Karen

Baggrund: Skolebørns opfattelse af sundhed har i høj grad noget med deres selvbilleder, trivsel og sociale inklusion at gøre. Det viser en lang række nyere undersøgelser, der alle peger på, at det er nødvendigt at skærpe opmærksomheden på børn og unges mentale sundhed. Internationalt er der...... udviklet og afprøvet en række pædagogiske programmer, der kan bruges til at igangsætte aktiviteter, der fremmer børn og unges mentale sundhed i skolen. Især i USA, Australien og Storbritannien har der været fokus på evidensbaseret praksis og praksisbaseret evidens i denne sammenhæng. I Danmark har man ikke...... på sammen måde tilgængelig systematiseret viden herom. Sundhedsstyrelsen har gennem de senere år prioriteret indsatser og fremskrivning af evidensgrundlag til fremme af mental sundhed højt. Betydningen af børns mentale sundhed og overvejelser om, hvilken slags evidens der er behov for på dette område...

Micropropagation of bulbous crops: technology and present state

NARCIS (Netherlands)

Klerk, de G.J.M.

2012-01-01

Conventional propagation of bulbous crops must be supplemented with micropropagation to satisfy the requirements of present-day horticulture with respect to fast production of disease-free, superior starting material. Adequate micropropagation protocols for bulbous crops are therefore a sine qua

Pop / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-2018

2005-01-01

Heliplaatidest: Jane Birkin "Rendez-Vous", Van Der Graaf Generator "Present", D-A-D "Scare Yourself", Quasimoto "The Further Adventures of Lord Quas", Van Morrison "Magic Time", Ry Cooder "Chavez Ravine", Erinevad esitajad "Blue Note Trip", Thievery Corporation "The Cosmic Game"

Haloquadratum

NARCIS (Netherlands)

Rodríguez-Valera, F.; Martin-Cuadrado, A.-B.; Bolhuis, H.

2016-01-01

Ha.lo.qua.dra'tum. Gr. masc. n. hals, halos salt, L. neut. n. quadratum square, N.L. neut. n. Haloquadratum salt square.Euryarchaeota / Halobacteria / Halobacteriales / HalobacteriaceaeThe haloarchaeal species Haloquadratum walsbyi, the only member described of the genus Haloquadratum, dominates

Incorporating field wind data to improve crop evapotranspiration parameterization in heterogeneous regions

Science.gov (United States)

Accurate parameterization of reference evapotranspiration (ET0) is necessary for optimizing irrigation scheduling and avoiding costs associated with over-irrigation (water expense, loss of water productivity, energy costs, pollution) or with under-irrigation (crop stress and suboptimal yields or qua...

Search for gluino-mediated bottom- and top-squark production in pp collisions at 8 TeV

CERN Document Server

CMS Collaboration

2013-01-01

The results are interpreted in the context of simplified models of new physics processes in which gluino pair production is followed by the decay of each gluino to an undetected particle and either two bottom quarks or two top qua...

Aquaculture genomics, genetics and breeding in the United States: Current status, challenges, and priorities for future research

Science.gov (United States)

Advancing the production efficiency and profitability of aquaculture is dependent upon the ability to utilize a diverse array of genetic resources. The ultimate goals of aquaculture genomics, genetics and breeding research are to enhance aquaculture production efficiency, sustainability, product qua...

Electron paramagnetic resonance study of ternary Cu compounds ...

Indian Academy of Sciences (India)

field modulation, and ∼19mW of microwave power. .... using EasySpin,38 a program working under Matlab39 as ... simulations obtained as explained in the text. σ denote the qua- ..... the exchange narrowing process is the collapse of reso-.

Medición de habilidades de comprensión lectora y auditiva en estudiantes de Pedagogía en Inglés de una universidad chilena

Directory of Open Access Journals (Sweden)

Cecilia Cisterna-Zenteno

2016-01-01

Full Text Available Recibido 14 de noviembre de 2014 • Corregido 1 de junio de 2015 • Aceptado 17 de noviembre de 2015El artículo presenta los resultados de una investigación cuyo objetivo fue medir las habilidades de comprensión lectora y auditiva de estudiantes de Pedagogía en Inglés de una universidad chilena. Para ello se aplicaron tres exámenes estandarizados de la Universidad de Cambridge: el examen English Test KET (KET, el Preliminary English Test (PET y el First Certificate Exam (FCE, a estudiantes de segundo, tercer y quinto año, respectivamente. Los datos recolectados fueron analizados con el programa SPSS mediante estadísticas descriptivas. Adicionalmente, estos resultados se complementaron con información recabada de tres grupos focales que tuvieron como propósito determinar las principales dificultades que se presentaron durante la ejecución de los exámenes. Los resultados revelaron que el estudiantado presenta problemas en la habilidad de comprensión auditiva y en la comprensión lectora en los exámenes KET y FCE, donde este último examen es el que obtuvo el más bajo nivel de logro. En cambio, en el examen PET, los puntajes de aprobación alcanzaron un mejor nivel. En los grupos focales, el estudiantado manifestó que sus principales dificultades fueron entender adecuadamente las instrucciones de cada tarea, el alto nivel de concentración requerido para rendir estos exámenes y la poca exposición a ensayos de este tipo de instrumentos de medición. El artículo plantea una posible explicación de los bajos resultados obtenidos en dos de los exámenes, utilizando el concepto de efecto meseta en el proceso de aprendizaje de una lengua. Se concluye con una reflexión sobre la formación inicial del profesorado de inglés en Chile, la importancia del conocimiento del contenido y los desafíos que enfrenta el sistema educativo y las instituciones formadoras a partir de los nuevos estándares pedagógicos establecidos por el

Comparability of Computer-based and Paper-based Versions of Writing Section of PET in Iranian EFL Context

OpenAIRE

Mohammad Mohammadi; Masoud Barzgaran

2010-01-01

Computer technology has provided language testing experts with opportunity to develop computerized versions of traditional paper-based language tests. New generations of TOEFL and Cambridge IELTS, BULATS, KET, PET are good examples of computer-based language tests. Since this new method of testing introduces new factors into the realm of language assessment ( e.g. modes of test delivery, familiarity with computer, etc.),the question may be whether the two modes of computer- and paper-based te...

Area Handbook Series. Albania: A Country Study

Science.gov (United States)

1992-04-01

inadequa prenal cue, tbe proportion of preature births increse •d from 7 to 11 perent between 197 amd early 1992. Hospits lacked es- sen"h mecidmund erp...were urgently needed to deal with the multiplying number of privately owned cars. Albanian entrepreneurs also 151 Albania: A Country Study imported... entrepreneurs from the reta marketplace. At first, peasants began setting up road- side fruit and vegetables stands or carrying their produce to mar- kets in

Rational Inhibitors of DNA Base Excision Repair Enzymes: New Tools for Elucidating the Role of BER in Cancer Chemotherapy. Addendum

Science.gov (United States)

2006-11-01

exponential decay to obtain koff (eq 5). Because of the very slow dissociation of UF‚M, its koff was measured by manually mixing a solution consisting...integrated high-throughput ( HTP ) platform for discovering small-molecule ligands that inhibit UNG. The strategy takes advantage of the extrahelical...robust HTP activity assay, and initial hits are quickly optimized using subsequent structure-activity studies. This tethering approach, which uses

Forord, midtersider og efterord i Hold Ud Bro

DEFF Research Database (Denmark)

Frølunde, Lisbeth

2016-01-01

, blyantspidserne hvisler henover papiret. Udenfor står en ung mand og ryger, man kan kun se hans ben, mens han snakker med fængselsbetjenten. Så er tiden gået. Nogen griner, nogen siger: ”Fuck det her mand, det er langt ude, det hænger slet ikke sammen”. Så læser vi vores tekster højt for hinanden. Da...

Food in Motion

DEFF Research Database (Denmark)

Andreassen, Pernille

Projektet 'Mad i bevægelse' er et treårigt projekt, som er udarbejdet af Kræftens Bekæmpelse og blev påbegyndt i 2005. Projektets overordnede formål har været at skabe mulighed for et sundere madvalg for børn og unge inden for idrætten, samt at stimulere udviklingen af en sundere madkultur i idræ...

Kurz zum Klima: Schatzsuche im Ozean – liegt die Zukunft des Bergbaus am Meeresgrund?

OpenAIRE

Albrecht-Saavedra, Jutta; Lippelt, Jana; Maierhofer, Leon

2013-01-01

Angesichts stark wachsender Nachfrage nach Rohstoffen, insbesondere vonseiten der aufstrebenden Schwellenländer und entsprechend steigender Rohstoffpreise, richtet sich der Blick zunehmend auf die Tiefsee als enorme noch weitgehend unerschlossene Quelle reichhaltiger Rohstoffvorkommen. Der KZK-Beitrag gibt einen Überblick über die Lagerstätten, die Erkundung und die geplante Erschließung der Tiefseeressourcen und weist auf die Risiken eines Ressourcenabbaus in der Tiefsee hin.

Datengeleitetes Lernen im studienbegleitenden Deutschunterricht am Beispiel des KoGloss-Ansatzes

OpenAIRE

Dubova, Agnese; Proveja, Egita

2016-01-01

Der vorliegende Aufsatz stellt den sprachdidaktischen Ansatz KoGloss vor und beschreibt die Möglichkeiten seines Einsatzes im studienbegleitenden Deutschunterricht. Als eine der Formen des datengeleiteten Lernens ermöglicht der KoGloss-Ansatz eine forschungsorientierte und lernerzentrierte Herangehensweise, die insbesondere im akademischen Sprachunterricht gefragt ist. Eine korpusbasierte Erschließung von (Fach-)Wörtern und komplexen sprachlichen Mustern, das learning by doing, die Kooperatio...

Doping, amazoner og supermænd

DEFF Research Database (Denmark)

Petersen, Thomas Søbirk

2007-01-01

Hvad får unge mennesker til at stræbe efter en karriere i idrættens elite, selvom det betyder hårdt dagligt arbejde i en lang årrække? Og er eliteidrætten overhovedet et felt for sundhed og selvrealisering, eller er den nærmere en ramme for vold og magt, forbundet med uhørt selvplageri? Det er no...

Rousseau som modsvar til forceret talentudvikling

DEFF Research Database (Denmark)

Holm, Claus; Nielsen, Jens Christian

2015-01-01

pædagogisk syn på børn og unges udvikling. Men dette syn er nu under pres. Det kommer for eksempel til udtryk, når en international idrætsaktør som FC Barcelona vil oprette elitært orienterede fodboldakademier for børn ned til 6-årsalderen i Danmark. Men inspireret af filosoffen Jean-Jacques Rousseau og...

PCR-Múltiple para el diagnóstico de Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum y Ureaplasma urealyticum

Directory of Open Access Journals (Sweden)

Nadia Rodríguez-Preval

2007-04-01

Full Text Available Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum y Ureaplasma urealyticum son especies relacionadas con enfermedades del tracto genitourinario, y particularmente con la uretritis no gonocócica (UNG en el hombre. Los cultivos de estos microorganismos resultan complicados, por lo que las técnicas moleculares, principalmente la reacción en cadena de la polimerasa (PCR, se han convertido en el principal método de detección de estos organismos. Objetivo: Implementar un método molecular basado en tecnología de genes para el diagnóstico de estas cuatro especies de micoplasmas genitales, aplicándolo en muestras clínicas de pacientes con UNG. Material y métodos: Se crearon las condiciones para un PCR-Múltiple para identificar estas especies empleando como muestra ADN de referencia, utilizando los juegos de cebadores complementarios a fragmentos de los genes de la proteína adhesiva de M. genitalium (MgPa, ARN ribosomal 16S de M. hominis, región espaciadora entre los genes del ARN ribosomal 16S y 23S de U. parvum, y de la región espaciadora adyacente al gen de la ureasa y específico para U. urealyticum, siendo un método específico y sensible. Resultados: Al analizar 34 muestras de exudado uretral, 27 correspondieron a la clase Mollicutes, obteniéndose 14,8% de positividad a M. genitalium, 18,5% a M. hominis, 11,1% a U. urealyticum y 3,7%. a U. parvum. Con este trabajo se realizó por primera vez el diagnóstico de M. genitalium, M. hominis, U. parvum y U. urealyticum en muestras uretrales de pacientes cubanos. Conclusión: Se recomienda incluir el diagnóstico de estas especies en un mayor número de pacientes cubanos con síntomas uretrales, para validar el método propuesto y conocer la relación de estos microorganismos con la UNG.

The Rise and Demise of the International Council for Science Policy Studies (ICSPS) as a Cold War Bridging Organization

Science.gov (United States)

Elzinga, Aant

2012-01-01

When the journal "Minerva" was founded in 1962, science and higher educational issues were high on the agenda, lending impetus to the interdisciplinary field of "Science Studies" "qua" "Science Policy Studies." As government expenditures for promoting various branches of science increased dramatically on…

Acoustic Wave Monitoring of Biofilm Development in Porous Media

Science.gov (United States)

Biofilm development in porous media can result in significant changes to the hydrogeological properties of subsurface systems with implications for fluid flow and contaminant transport. As such, a number of numerical models and simulations have been developed in an attempt to qua...

Improving recombinant protein purification yield

Science.gov (United States)

Production of adequate amounts of recombinant proteins is essential for antibody production, biochemical activity study, and structural determination during the post-genomic era. It’s technologically challenging and a limiting factor for tung oil research because analytical reagents such as high qua...

Being qua becoming: Aristotle's "Metaphysics", quantum physics, and Process Philosophy

Science.gov (United States)

Johnson, David Kelley

In Aristotle's First Philosophy, science and philosophy were partners, but with the rise of empiricism, went their separate ways. Metaphysics combined the rational and irrational (i.e. final cause/unmoved mover) elements of existence to equate being with substance, postulating prime matter as pure potential that was actuated by form to create everything. Modern science reveres pure reason and postulates its theory of being by a rigorous scientific methodology. The Standard Model defines matter as energy formed into fundamental particles via forces contained in fields. Science has proved Aristotle's universe wrong in many ways, but as physics delves deeper into the quantum world, empiricism is reaching its limits concerning fundamental questions of existence. To achieve its avowed mission of explaining existence completely, physics must reunite with philosophy in a metascience modeled on the First Philosophy of Aristotle. One theory of being that integrates quantum physics and metaphysics is Process Philosophy.

Democracy, Political Competition and Public Debt

Directory of Open Access Journals (Sweden)

Lucian CROITORU

2015-06-01

Full Text Available There are two major preferences shaping political choices: one, regarding who should play the leading role in running the economy (mar-kets or politicians and the other, concerning social spending. According to reputation, leftist parties assign the leading role to politicians (i.e. the state, whereas rightist parties entrust mar-kets with the central role in running the econo-my. Right-wing parties’ reputation of not favoring social spending is not backed by facts. Since both the left and the right display similar behav-iors vis-à-vis social spending, it is preferable that markets play the central role in running the econ-omy. Flexible markets help economic growth and employment, reducing the need for high social spending. The freedom of property and freedom from corruption indexes show that, in Romania, the market has never played the central role in running the economy. People’s prevailing con-cern over their wellbeing ‘now’ rather than ‘to-morrow’ generates competition among political right and left for higher social spending, leading to high public debt. Neither left, nor right can guarantee sustainable limits for social benef ts and public debt. Capping the share of public debt in GDP by means of the Constitution provides no guarantee for public debt sustainability, but is worth a try.

Inner heliosphere spatial gradients of GCR protons and alpha particles in the low GeV range

Science.gov (United States)

Gieseler, J.; Boezio, M.; Casolino, M.; De Simone, N.; Di Felice, V.; Heber, B.; Martucci, M.; Picozza, P.

2013-12-01

The spacecraft Ulysses was launched in October 1990 in the maximum phase of solar cycle 22, reached its final, highly inclined (80.2°) Keplerian orbit around the Sun in February 1992, and was finally switched off in June 2009. The Kiel Electron Telescope (KET) aboard Ulysses measures electrons from 3 MeV to a few GeV and protons and helium in the energy range from 6 MeV/nucleon to above 2 GeV/nucleon. In order to investigate the radial and latitudinal gradients of galactic cosmic rays (GCR), it is essential to know their intensity variations for a stationary observer in the heliosphere because the Ulysses measurements reflect not only the spatial but also the temporal variation of the energetic particle intensities. This was accomplished in the past with the Interplanetary Monitoring Platform-J (IMP 8) until it was lost in 2006. Fortunately, the satellite-borne experiment PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) was launched in June 2006 and can be used as a reliable 1 AU baseline for measurements of the KET aboard Ulysses. With these tools at hand, we have the opportunity to determine the spatial gradients of GCR protons and alpha particles at about 0.1 to 1 GeV/n in the inner heliosphere during the extended minimum of solar cycle 23. We then compare these A0 cycle.

Making health policy

National Research Council Canada - National Science Library

Buse, Kent; Mays, Nicholas; Walt, Gill

2012-01-01

... understanding of the inevitable limits of individual health care and of the need to complement such services with effective public health strategies. Major improvements in people's health will come from controlling communicable diseases, eradicating environmental hazards, improving people's diets and enhancing the availability and qua...

Ad Iuvenci Evangeliorum : librum primum commentarius exegeticus

NARCIS (Netherlands)

Kievits, Herman Hendrik

1940-01-01

De Gaio Vettio Aquilino Iuvenco pauca admodum scimus. Natus fuit in Hispania, sed nescimus in qua regionis parte. Secundum adnotationes nullo fundamento innitentes 1) patria eius fuit Vettoniae urbs Caesarobriga (= Talavera de la Reina), in dextra Tagi ripa sita, sed ea fama ex similitudine nominum

Binary Positive Semidefinite Matrices and Associated Integer Polytopes

DEFF Research Database (Denmark)

Letchford, Adam N.; Sørensen, Michael Malmros

2012-01-01

We consider the positive semidefinite (psd) matrices with binary entries, along with the corresponding integer polytopes. We begin by establishing some basic properties of these matrices and polytopes. Then, we show that several families of integer polytopes in the literature-the cut, boolean qua...

Teratoma Formation by Human Embryonic Stem Cells is site-dependent and enhanced by the presence of Matrigel

DEFF Research Database (Denmark)

Prokhorova, Tatyana A; Harkness, Linda M; Frandsen, Ulrik

2008-01-01

When implanted into immunodeficient mice, human embryonic stem cells (hESC) give rise to teratoma, tumour-like formations containing tissues belonging to all three germ layers. The ability to form teratoma is a sine qua non characteristic of pluripotent stem cells. However, limited data...

The South Eastern Europe Brigade: An Option for NATO-Led Peace Support Operations?

Science.gov (United States)

2011-06-10

Ireland, Lithuania, the Netherlands, Norway, Poland, Portugal , Romania, Slovenia, Spain, and Sweden), while 7 more nations (Chile, Croatia, Czech...fundamentals are very important factors in establishing the suitability of SEEBRIG for PSO. They are ― sine qua non‖ principles for any type of mission

The Challenge to USAFRICOM from Africa’s Colonial Past

Science.gov (United States)

2010-03-18

build national treasure through colonization and empire building was on. Seven nations—Britain, France, Portugal , Belgium, Germany, Italy and Spain...ability to diminish the local support and sanctuary for terrorists that is the sine qua non of their global reach. • American deeds matter more

INDUCTION OF DNA ADDUCTS, TUMORS, AND KI-RAS ONCOGENE MUTATIONS IN STRAIN A/J MOUSE LUNG BY IP. ADMINISTRATION OF DIBENZ[A,H]ANTHRACENE

Science.gov (United States)

Induction of DNA adducts, tumors, and Ki-ras oncogene mutations in strain AlJ mouse lung by ip. administration of dibenz[a,h]anthracene Previous studies of polycyclic aromatic hydrocarbon (P AH) induced lung tumors in the strain NJ mouse model system have demonstrated qua...

Multiple Voices, Multiple Realities: Self-Defined Images of Self among Adolescent Hispanic English Language Learners

Science.gov (United States)

Ajayi, Lasisi J.

2006-01-01

Acquisition of multiple identities to negotiate new forms of social participation and the concomitant attendant multiple languages and multiple cultures is "sine qua non" to success in English language learning classrooms. This study therefore, investigates how middle school Hispanic students reconceptualize their identities to negotiate…

Indigenous Angiosperm biodiversity of Olabisi Onabanjo University ...

African Journals Online (AJOL)

The conservation of the genetic variability of the indigenous angiosperm community is a sine qua non. A survey of indigenous angiosperm biodiversity of the Olabisi Onabanjo University permanent site was undertaken. Plants collected were dried, poisoned and mounted on herbarium sheets, proper identification and ...

La religione nell’ordinamento algerino tra previsioni costituzionali e normativa ordinaria in materia di esercizio dei culti diversi dal musulmano

Directory of Open Access Journals (Sweden)

Maria Cristina Ivaldi

2012-11-01

SOMMARIO: 1. Rilievi introduttivi – 2. Il trattamento riservato alla religione nelle costituzioni algerine postcoloniali – 3. La disciplina in materia di esercizio dei culti diversi dal musulmano varata nel 2006 – 4. I decreti di esecuzione della normativa de qua – 5. Tendenze evolutive:

Properties of solar proton events at large heliocentric distances near ecliptic

International Nuclear Information System (INIS)

Khiber, B.; Struminskij, A.B.

2005-01-01

The absolute intensities, fluences and propagation times of the solar protons with the energy of 38-125 MeV, obtained on the basis of the observation data of the Kilskij electron telescope (KET ULYSSES) onboard the ULYSSES cosmic apparatus and GOES proton detector, are compared. The observation data on the solar cosmic rays at the heliocentric distances above 5 a.e. are analyzed for the first time. Certain characteristics of the proton events under consideration and their possible parent flares are presented [ru

Integrating Health Promotion, Learning and Sustainability in school foodscapes - the LOMA case study

DEFF Research Database (Denmark)

Ruge, Dorte

2015-01-01

Forbedring af børn og unges sundhed er en væsentlig samfundsmæssig udfordring i både udviklede lande og udviklingslande. Fedme og overvægt blandt børn er øget i løbet af de sidste 10 år og er forbundet med en øget risiko for hjerte-kar-sygdomme og diabetes. Desuden har overvægtige børn har tenden...

Öffnung für alle

Directory of Open Access Journals (Sweden)

Sascha Dickel

2017-08-01

Full Text Available Der Buchdruck ermöglichte die Ausdifferenzierung eines modernen Wissenschaftssystems, das in kognitiver Hinsicht auf Offenheit orientiert ist. Die Mertonschen Normen können als Selbstreflexion dieser Orientierung an Offenheit interpretiert werden. An ihnen wird sichtbar, dass sich die zeitliche und sachliche Offenheit der Wissenschaft paradoxerweise durch ihre soziale Schließung als Profession vollzieht. Diese Professionsgrenze wissenschaftlicher Praxis wird durch Open Science in Frage gestellt.

Mädchenschulen: Dramatisierung oder Entdramatisierung von Geschlecht? Eine verschränkende Darstellung vertiefter quantitativer und qualitativer empirischer Analysen zur 'Wirkungsweise' der Geschlechtersegregation

OpenAIRE

Schurt, Verena

2011-01-01

Wie die Ergebnisse aktueller Bildungsstudien verdeutlichen, werden die Unterschiede zwischen Mädchen und Jungen zwar insbesondere in Bezug auf den formalen Schulerfolg immer geringer, allerdings bestehen nach wie vor bereichsspezifische Geschlechterdifferenzen, die ihren Niederschlag u.a. in der (ökonomisch und sozial) meist ungünstigeren Situation von Frauen im Erwerbsleben finden. Vor diesem Hintergrund stellt sich die Ausgangsfrage, ob monoedukative Schulen Chancen für eine Nivellierung ge...

Fortælleværksteder

DEFF Research Database (Denmark)

Krøjer, Jo; Hutters, Camilla

2009-01-01

Unges valg af videregående uddannelse er omgærdet af forventninger. Forventninger til hvad man skal vælge. Forventninger til hvor lang tid, man skal være om at tage en uddannelse. Og forventninger til, hvad uddannelsen skal føre til. Artiklen præsenterer fortælleværkstedet, en metode til kollekti...... refleksioner over egne og adres forventninger til og tanker om uddannelsesvalg....

Akzeptanz von Location Based Services

OpenAIRE

Bauer, Hans H.; Haber, Tobias E.; Reichardt, Tina; Bökamp, Marten

2006-01-01

Die enormen Investitionen in UMTS-Lizenzen und den Aufbau einer neuen Netzinfrastruktur zwingen die Mobilfunkanbieter zur Erschließung neuer Umsatzpotenziale. Durch Entwicklung neuer mobiler Mehrwertdienste hoffen sie, die „Killerapplikation“ der 3. Mobilfunkgeneration zu finden, die ähnlich wie der Short Message Service (SMS) für GSM, zum Treiber des UMTS-Markterfolges werden kann. Nach Meinung vieler Marktbeobachter könnten Location Based Services, d.h. mobile Dienste, die ...

Pathways through education for young people in care

DEFF Research Database (Denmark)

Jensen, Niels Rosendal

2014-01-01

Anmeldelsen fremhæver, at denne antologi redigeret af Sonia Jackson viser, at børn og unge anbragt uden for eget hjem synes at være undervurderede i forhold til uddannelse, og at de professionelles forventninger til de anbragte er for lave. Ganske vist vises eksempler på, hvordan det kan lykkes a...... at forene anbringelse med uddannelse, men dette er undtagelsen, der bekræfter hovedreglen....