WorldWideScience

Sample records for karise marika mnd

  1. checkCIF/PLATON report Datablock: mnd

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: mnd. Bond precision:.

  2. Establishing the UK DNA Bank for motor neuron disease (MND).

    Science.gov (United States)

    Smith, Lucy; Cupid, B C; Dickie, B G M; Al-Chalabi, A; Morrison, K E; Shaw, C E; Shaw, P J

    2015-07-14

    In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an important resource to researchers worldwide and significantly increase activity in MND genetic research. The DNA Bank houses over 3000 high quality DNA samples, all of which were donated by people living with MND, family members and non-related controls, accompanied by clinical phenotype data about the patients. Today the primary focus of the UK MND DNA Bank still remains to identify causative and disease modifying factors for this devastating disease.

  3. Nauding kehale ja meelele / Marika Aret ; tekst Inna Inanna

    Index Scriptorium Estoniae

    Aret, Marika

    2014-01-01

    Mustamäel Mustamäe tee 17 avatud Bliss majast, kus muude teenuste kõrval pakutakse buffeeerestoranis ja kohvikus taime- ja toortoitu. Intervjuu Blissi käivitustiimi ja restorani perenaise Marika Aretiga

  4. Management of respiration in MND/ALS patients: an evidence based review.

    Science.gov (United States)

    Heffernan, Catherine; Jenkinson, Crispin; Holmes, Tricia; Macleod, Heidi; Kinnear, William; Oliver, David; Leigh, Nigel; Ampong, Mary-Ann

    2006-03-01

    This systematic review comprises an objective appraisal of the evidence in regard to the management of respiration in patients with motor neuron disease (MND/ALS). Studies were identified through computerised searches of 32 databases. Internet searches of websites of drug companies and MND/ALS research web sites, 'snow balling' and hand searches were also employed to locate any unpublished study or other 'grey literature' on respiration and MND/ALS. Since management of MND/ALS involves a number of health professionals and care workers, searches were made across multiple disciplines. No time frame was imposed on the search in order to increase the probability of identifying all relevant studies, although there was a final limit of March 2005. Recommendations for patient and carer-based guidelines for the clinical management of respiration for MND/ALS patients are suggested on the basis of qualitative analyses of the available evidence. However, these recommendations are based on current evidence of best practice, which largely comprises observational research and clinical opinion. There is a clear need for further evidence, in particular randomised and non-randomised controlled trials on the effects of non-invasive ventilation and additional larger scale cohort studies on the issues of initial assessment of respiratory symptoms, and management and timing of interventions.

  5. Guidelines for preclinical animal research in ALS/MND: A consensus meeting.

    Science.gov (United States)

    Ludolph, Albert C; Bendotti, Caterina; Blaugrund, Eran; Chio, Adriano; Greensmith, Linda; Loeffler, Jean-Philippe; Mead, Richard; Niessen, Heiko G; Petri, Susanne; Pradat, Pierre-Francois; Robberecht, Wim; Ruegg, Markus; Schwalenstöcker, Birgit; Stiller, Detlev; van den Berg, Leonard; Vieira, Fernando; von Horsten, Stephan

    2010-01-01

    The development of therapeutics for ALS/MND is largely based on work in experimental animals carrying human SOD mutations. However, translation of apparent therapeutic successes from in vivo to the human disease has proven difficult and a considerable amount of financial resources has been apparently wasted. Standard operating procedures (SOPs) for preclinical animal research in ALS/MND are urgently required. Such SOPs will help to establish SOPs for translational research for other neurological diseases within the next few years. To identify the challenges and to improve the research methodology, the European ALS/MND group held a meeting in 2006 and published guidelines in 2007 (1). A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott.

  6. Assessing social isolation in motor neurone disease: a Rasch analysis of the MND Social Withdrawal Scale.

    Science.gov (United States)

    Gibbons, Chris J; Thornton, Everard W; Ealing, John; Shaw, Pamela J; Talbot, Kevin; Tennant, Alan; Young, Carolyn A

    2013-11-15

    Social withdrawal is described as the condition in which an individual experiences a desire to make social contact, but is unable to satisfy that desire. It is an important issue for patients with motor neurone disease who are likely to experience severe physical impairment. This study aims to reassess the psychometric and scaling properties of the MND Social Withdrawal Scale (MND-SWS) domains and examine the feasibility of a summary scale, by applying scale data to the Rasch model. The MND Social Withdrawal Scale was administered to 298 patients with a diagnosis of MND, alongside the Hospital Anxiety and Depression Scale. The factor structure of the MND Social Withdrawal Scale was assessed using confirmatory factor analysis. Model fit, category threshold analysis, differential item functioning (DIF), dimensionality and local dependency were evaluated. Factor analysis confirmed the suitability of the four-factor solution suggested by the original authors. Mokken scale analysis suggested the removal of item five. Rasch analysis removed a further three items; from the Community (one item) and Emotional (two items) withdrawal subscales. Following item reduction, each scale exhibited excellent fit to the Rasch model. A 14-item Summary scale was shown to fit the Rasch model after subtesting the items into three subtests corresponding to the Community, Family and Emotional subscales, indicating that items from these three subscales could be summed together to create a total measure for social withdrawal. Removal of four items from the Social Withdrawal Scale led to a four factor solution with a 14-item hierarchical Summary scale that were all unidimensional, free for DIF and well fitted to the Rasch model. The scale is reliable and allows clinicians and researchers to measure social withdrawal in MND along a unidimensional construct. © 2013. Published by Elsevier B.V. All rights reserved.

  7. Transition probabilities and dissociation energies of MnH and MnD molecules

    International Nuclear Information System (INIS)

    Nagarajan, K.; Rajamanickam, N.

    1997-01-01

    The Frank-Condon factors (vibrational transition probabilities) and r-centroids have been evaluated by the more reliable numerical integration procedure for the bands of A-X system of MnH and MnD molecules, using a suitable potential. By fitting the Hulburt- Hirschfelder function to the experimental potential curve using correlation coefficient, the dissociation energy for the electronic ground states of MnH and MnD molecules, respectively have been estimated as D 0 0 =251±5 KJ.mol -1 and D 0 0 =312±6 KJ.mol -1 . (authors)

  8. Fourier transform spectroscopy of MnH and MnD

    Science.gov (United States)

    Balfour, W. J.; Launila, O.; Klynning, L.

    Two infrared band systems, centred near 846 nm and 1060 nm in both MnH and MnD have been rotationally analysed and shown to have a common lower state. The electronic transitions lie within the quintet manifold and are here designated c 5Σ-a 5Σ and b 5Πi-a 5Σ for the 846 and 1060 nm systems, respectively. In the 846 nm system in MnH all 10 main branches have been found in the 0-0 and 1-1 bands, while in MnD the data are complete only for 0-0. Satellite branches have been identified in the 1060 nm system and all spin and Λ-type doublings have been established. The number of assigned 0-0 branches in the 1060 nm system is 35 for MnH and 37 for MnD. Molecular constants have been determined for all three states involved. Λ-doubling diagrams are presented for b 5Πi state with v = 1, 2 levels in MnH and with the v = 2 level in MnD. Local perturbations in c5Σ (v = 1) in MnH are suspected to originate from the v = 3 level of b 5Πi.

  9. Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) - from diagnosis to patient care.

    Science.gov (United States)

    Mitchell, J D

    2000-12-01

    This paper reviews the scope of current guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) and examines issues which have arisen in the preparation of these documents. The review concludes with an evaluation of the impact of the guidelines which have been produced to date and looks towards potential future developments in this area.

  10. Fourier transform infrared emission spectra of MnH and MnD

    Science.gov (United States)

    Gordon, Iouli E.; Appadoo, Dominique R. T.; Shayesteh, Alireza; Walker, Kaley A.; Bernath, Peter F.

    2005-01-01

    Fourier transform infrared emission spectra of MnH and MnD were observed in the ground X7Σ + electronic state. The vibration-rotation bands from v = 1 → 0 to v = 3 → 2 for MnH and from v = 1 → 0 to v = 4 → 3 for MnD were recorded at an instrumental resolution of 0.0085 cm -1. Spectroscopic constants were determined for each vibrational level and equilibrium constants were found from a Dunham-type fit. The equilibrium vibrational constant ( ωe) for MnH was found to be 1546.84518(65) cm -1, the equilibrium rotational constant ( Be) is 5.6856789(103) cm -1 and the eqilibrium bond distance ( re) was determined to be 1.7308601(47) Å.

  11. Brittle and ductile rupture of 16MND5 steel. Irradiation effect

    International Nuclear Information System (INIS)

    Al Mundheri, M.; Soulat, P.; Pineau, A.

    1986-06-01

    Toughness tests have been made on 16MND5 steel (A508Cl3 steel) - before and after irradiation at 290 0 C (3.10 19 n/cm 2 , E > 1 MeV). It is shown that toughness is lowered following the irradiation and that it is a decreasing function of the thickness of the test pieces. In parallel, tests on three geometries of entailed specimens, prepared in the non-irradiated material, have been made at different temperatures to apply the methodology of local approach of ductile-brittle rupture [fr

  12. Microstructural influence on the local behaviour of 16MND5 steel

    International Nuclear Information System (INIS)

    Sekfali, S.

    2004-06-01

    16MND5 Steel or A508 Cl3 is used for manufacture by forging of nuclear reactor vessels. This material presents a good compromise in term of tenacity and yield stress, its microstructure is mainly bainitic tempered. Because of the chemical composition local variation and process of development, this material presents microstructural heterogeneities which can locally modify the properties of damage. In particular, some zones present a martensitic microstructure. The goal of this thesis is to bring some explanations on the influence of the microstructure; more particularly, size of the crystallographic entities and their spatial distribution on the local behaviour of 16MND5 steel. Two microstructures were elaborated for this purpose, a tempered bainitic microstructure and a tempered martensitic microstructure. An experimental characterization was carried out on the two microstructures in order to determine morphology, spatial distribution of the crystallographic orientations and tensile behaviour. A deposit of micro grid was carried out on tensile specimens to determine the experimental deformation field on a beforehand EBSD analyzed zone. The determination of the tensile behaviour allowed the identification of a multi crystalline behaviour law by a reverse method using the density of dislocation on each system of slip. This behaviour law was used in simulations with a finite element method to simulate the local mechanical field of the two microstructures and to compare with the obtained experimental deformation fields. It results, a good adequacy between simulations and experiments and the description of the influence of the neighbor grain's orientation on the local behaviour. (author)

  13. The Submillimeter Spectrum of MnH and MnD (X7Σ+)

    Science.gov (United States)

    Halfen, D. T.; Ziurys, L. M.

    2008-01-01

    The submillimeter-wave spectrum of the MnH and MnD radicals in their 7Σ+ ground states has been measured in the laboratory using direct absorption techniques. These species were created in the gas phase by the reaction of manganese vapor, produced in a Broida-type oven, with either H2 or D2 gas in the presence of a DC discharge. The N = 0 → 1 transition of MnH near 339 GHz was recorded, which consisted of multiple hyperfine components arising from both the manganese and hydrogen nuclear spins. The N = 2 → 3 transition of MnD near 517 GHz was measured as well, but in this case only the manganese hyperfine interactions were resolved. Both data sets were analyzed with a Hund's case b Hamiltonian, and rotational, fine structure, magnetic hyperfine, and electric quadrupole constants have been determined for the two manganese species. An examination of the magnetic hyperfine constants shows that MnH is primarily an ionic species, but has more covalent character than MnF. MnH is a good candidate species for astronomical searches with Herschel, particularly toward material associated with luminous blue variable stars.

  14. Characterizations of microstructural evolutions to heating of two 16MND5 alloys

    International Nuclear Information System (INIS)

    Vereecke, B.

    2003-01-01

    The aim of this work is to predict the risks of ruin of power plants from scenario of accidents. For that, we have to know and simulate the behaviour of material at high temperatures (600-1300 C) or more exactly, of materials of analogous composition but of different sources, constituting the vessel of a PWR reactor in 16MND5 steel. Previous studies (Vereecke and al CFM2003) have shown that the vessel steels can present in the temperature range 900-1000 C an important variability of creep behaviour and in particular of damages mechanisms (ductile or intergranular) which can radically change from a steel to another. In order to explain and model the sources of different damages, we have carried out a metallurgical study on two steels of 16MND5 type. For different kinetics of heating, have been studied: the hardnesses, the grain sizes and the thermo-electric power (TEP). This last qualitative physical measurement allows to follow in our case the dissolution of the alloy elements having precipitated, phenomenon which could be at the origin of the differences of the damage mechanisms noticed at high temperature. (O.M.)

  15. Uniaxial low cycle fatigue behavior for pre-corroded 16MND5 bainitic steel in simulated pressurized water reactor environment

    Science.gov (United States)

    Chen, Xu; Ren, Bin; Yu, Dunji; Xu, Bin; Zhang, Zhe; Chen, Gang

    2018-06-01

    The effects of uniaxial tension properties and low cycle fatigue behavior of 16MND5 bainitic steel cylinder pre-corroded in simulated pressurized water reactor (PWR) were investigated by fatigue at room temperature in air and immersion test system, scanning electron microscopy (SEM), energy disperse spectroscopy (EDS). The experimental results indicated that the corrosion fatigue lives of 16MND5 specimen were significantly affected by the strain amplitude and simulated PWR environments. The compositions of corrosion products were complexly formed in simulated PWR environments. The porous corrosion surface of pre-corroded materials tended to generate pits as a result of promoting contact area to the fresh metal, which promoted crack initiation. For original materials, the fatigue cracks initiated at inclusions imbedded in the micro-cracks. Moreover, the simulated PWR environments degraded the mechanical properties and low cycle fatigue behavior of 16MND5 specimens remarkably. Pre-corrosion of 16MND5 specimen mainly affected the plastic term of the Coffin-Manson equation.

  16. Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS)--from diagnosis to patient care.

    Science.gov (United States)

    Mitchell, J D

    2000-12-01

    This paper reviews the scope of current guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) and examines issues which have arisen in the preparation of these documents. The review concludes with an evaluation of the impact of the guidelines which have been produced to date and looks towards potential future developments in this area.

  17. Stress distribution in the 16MND5 bainitic steel. Experimental analysis and polycrystalline modelling

    International Nuclear Information System (INIS)

    Pesci, R.; Inal, K.; Berveiller, M.; Masson, R.

    2003-01-01

    The 16MND5 bainitic steel being a two-phase material (ferrite/cementite), the X-Ray Diffraction (XRD) is the most efficient tool to determine the stress states into the ferritic phase (sin 2 ψ method). The latter, coupled to the observations realized during tensile tests (specimen surface and facies), have permitted to establish criteria to describe the behavior and the damaging processes of the material on a crystallographic scale, in the lower part of the ductile-to-brittle transition region and at lower temperatures [-196 deg. C;-60 deg. C]. During the loading, the damage is observed with a Scanning Electron Microscope, while the internal stresses are determined by XRD: the stress states are less important in ferrite than in bainite (macroscopic stress), the difference not exceeding 150 MPa. A multi-scale polycrystalline model is developed concurrently with the experimental measurements: a Mori-Tanaka formulation is used to describe the elastoplastic behavior of a ferritic single crystal reinforced by cementite precipitates, while the transition to the polycrystal is achieved by a self-consistent approach. The developed modeling takes into account the temperature effects on the stress states in each phase and includes a cleavage criterion (critical value of the stress normal to [100] planes), which expresses the damage of the material: thus, it enables to predict the actual experimental behavior of the 16MND5 steel in relation to temperature, and to take into account the failure process which is fragile from -120 deg. C. Besides, it is also possible to calculate the strains of the diffracting planes, which can be compared to those measured by XRD: this enables to evaluate the heterogeneity of the strains for each crystallographic orientation. (authors)

  18. 'All in the same boat'? Patient and carer attitudes to peer support and social comparison in Motor Neurone Disease (MND).

    Science.gov (United States)

    Locock, Louise; Brown, Janice B

    2010-10-01

    This paper explores attitudes to peer support among people with Motor Neurone Disease (MND) and their family carers. It reports findings from a secondary analysis of data from two UK interview studies conducted by the authors. The process of secondary analysis is reported in detail. 48 people with MND and 22 carers were interviewed in 2005-2007. The authors identified narrative extracts on peer support from their own datasets and exchanged them for independent thematic analysis. Subsequent discussion, drawing on literature on support groups and social comparison, led to an exploration of two overarching themes: valuing camaraderie and comparison, and choosing isolation. Findings suggest that social comparison theory is a useful framework for analysing attitudes to MND support groups, but that on its own it is insufficient. 'Valuing camaraderie and comparison' explains how support groups offer practical and social support, as well as beneficial opportunities for social comparison. Seeing others coping well with the condition can provide hope, while downward comparison with those worse off can also make people feel better about their own situation. However, most people are also shocked and saddened by seeing others with the condition. Tension of identity can occur when group membership starts to define the individual as 'a person with MND, rather than the person I am that happens to have MND'. Choosing isolation can be a deliberate defensive strategy, to protect oneself from witnessing one's possible future. Levels of involvement may change over time as people struggle with their changing needs and fears. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. From symptom onset to a diagnosis of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND): experiences of people with ALS/MND and family carers - a qualitative study.

    Science.gov (United States)

    O'Brien, Mary R; Whitehead, Bridget; Jack, Barbara A; Mitchell, John Douglas

    2011-03-01

    Our objectives were to explore the personal perspectives of the diagnostic experience for people with ALS/MND and their family carers identifying issues that could impact positively or negatively on these experiences. We conducted a qualitative study with face-to-face interviews to capture experiences from 24 people with ALS/MND and 18 current family carers. Ten former family carers were also interviewed. The diagnostic experience was fraught with difficulties. There was failure to recognize the significance of some symptoms by patients, carers and primary and secondary care health professionals, which ultimately delayed diagnosis. Delivery of the diagnosis was frequently unsatisfactory despite international guidelines on the subject. Immediate post-diagnosis support often compared negatively to that provided for people with cancer. In conclusion, this study has identified a need for a more streamlined and empathetic diagnostic pathway for people with ALS/MND. Improvements to medical curricula are required to increase awareness of the condition and reduce the likelihood of diagnostic delays resulting from a failure to recognize the need for a neurological referral. Greater public awareness of the illness is also needed. Furthermore, delivery of the diagnosis should more closely adhere to established guidelines.

  20. Diffusion-bonded 16MND5-Inconel 690-316LN junction: elaboration and process residual stresses modeling

    International Nuclear Information System (INIS)

    Martinez, Michael

    1999-01-01

    The objective of this research thesis is, on the one hand, to elaborate and to characterise a bonded junction of 16MND5 and 316LN steels, and, on the other hand, to develop a simulation tool for the prediction of microstructures after bonding, as well as residual stresses related to this process. The author first reports the study of the use of diffusion bonding by hot isostatic pressing (HIP diffusion bonding) for the bonding of 16MND5 (steel used in French PWR vessel) and 316LN (austenitic stainless steel used in piping), in order to obtain junctions adapted to a use within PWRs. In this case, the use of an Inconel insert material appeared to be necessary to avoid stainless steel carburization. Thus, inserts in Inconel 600 and 690 have been tested. The objective has then been to develop a realistic calculation of residual stresses in this assembly. These stresses are stimulated by quenching. The author notably studied the simulation of temperature dependent phase transformations, and stress induced phase transformations. An existing model is validated and applied to HIP and quenching cycles. The last part reports the calculation of residual stresses by simulation of the mechanical response of the three-component material cooled from 900 C to room temperature and thus submitted to a loading of thermal origin (dilatation) and metallurgical origin (phase transformations in the 16MND5). The effect of carbon diffusion on mechanical properties has also been taken into account. The author discusses problems faced by existing models, and explains the choice of conventional macro-mechanical models. The three materials are supposed to have a plastic-viscoplastic behaviour with isotropic and kinematic strain hardening, and this behaviour is identified between 20 and 900 C [fr

  1. Withdrawal of ventilation at the patient's request in MND: a retrospective exploration of the ethical and legal issues that have arisen for doctors in the UK.

    Science.gov (United States)

    Phelps, Kay; Regen, Emma; Oliver, David; McDermott, Chris; Faull, Christina

    2017-06-01

    Ventilatory support has benefits including prolonging survival for respiratory failure in motor neurone disease (MND). At some point some patients may wish to stop the intervention. The National Institute of Health and Care Excellence (NICE) guidance recommends research is needed on ventilation withdrawal. There is little literature focusing on the issues doctors encounter when withdrawing ventilation at the request of a patient. To identify and explore with doctors the ethical and legal issues that they had encountered in the withdrawal of ventilation at the request of a patient with MND. A retrospective thematic analysis of interviews of 24 doctors (including palliative care, respiratory, neurology and general practice) regarding their experiences with withdrawal of ventilation support from patients with MND. Respondents found withdrawal of ventilation at the request of patients with MND to pose legal, ethical and moral challenges in five themes: ethical and legal rights to withdrawal from treatment; discussions with family; discussions with colleagues; experiences of legal advice; issues contributing to ethical complexity. Though clear about the legality of withdrawal of treatment in theory, the practice led to ethical and moral uncertainty and mixed feelings. Many respondents had experienced negative reactions from other healthcare professionals when these colleagues were unclear of the distinction between palliation of symptoms, withdrawal of treatment and assisted death. Legal, ethical and practical guidance is needed for professionals who support a patient with MND who wishes to withdraw from ventilation. Open discussion of the ethical challenges is needed as well as education and support for professionals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  2. Prediction of cleavage crack propagation and arrest in a nuclear pressure vessel steel (16MND5) under thermal shock

    International Nuclear Information System (INIS)

    Yang, Xiaoyu

    2015-01-01

    The purpose of this PhD study is to predict the propagation and arrest of cleavage cracks in a French PWR vessel steel (16MND5). This is accomplished through use of a local criterion based on the critical stress calculated ahead of crack tip. Previous work has shown that fracture mechanism was cleavage associated with the ductile shear zone between the different planes of cracking. Thus, the critical stress at crack tip depends on stain rate. This thesis consists of numerical optimization, identification and validation of a local criterion based on experiments which have complex thermomechanical loads. The criterion accounts for various crack paths, deepening the knowledge about micro mechanisms during crack propagation in order to justify the established criterion. Criterion identification was carried out by using numerical simulations of tension tests performed on CT (Compact Tension) specimens at four different temperatures (-150 C, -125 C, -100 C and -75 C). The eXtended Finite Element Method (X-FEM) was used in CAST3M FE software to model dynamic crack propagation and arrest. The analysis results in 2D and 3D showed that the critical stress at crack tip increased with the inelastic strain rate. Therefore, a criterion based on the critical stress was established. An analytical model was developed to justify the identified criterion. The critical stress given by the local criterion was considered as the sum of the critical cleavage stress and the stress generated by the deformation of ligaments behind the crack tip. In order to quantify this phenomenon, measurements of ligaments' characteristics have been performed on fracture surfaces and on cross-sections of the specimens. The stress profile of the crack lips generated by ligaments was calculated by modeling of multi-cracks on specimen's cross-section. The contribution of stress generated by ligaments to the critical stress at crack tip was obtained with this method, and then the analytical model of

  3. Imekliinik Brasiilias / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    Brasiilia Abadiania väikelinnas asuvast Casa de Dom Inacio tervendamiskeskusest, kus meediumi vahendusel toimuvad meditatsioonid ja "operatsioonid" ning inimesed paranevad lühikese ajaga rasketest haigustest. Seal ravil käinud Eesti naise kogetust

  4. Annid merest / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Toiduks tarvitatavatest koorikloomadest ja molluskitest: krabi, krevett, garneel, homaar e merivähk, jõe- e väärisvähk, signaal- e tähnikvähk, langust e ogajas merivähk, auster, kammkarp, rannakarp, kaheksajalg, kalmaar, seepia e tindikala, meritigu e tõrikodalane, viinamäe- e burgundia tigu, merisiilik ning kalatootest surimi e makra

  5. Influence of metallurgical phase transformation on crack propagation of 15-5PH stainless steel and 16MND5 low carbon steel

    International Nuclear Information System (INIS)

    Liu, J.

    2012-01-01

    This study focuses on the effects of phase transformations on crack propagation. We want to understand the changes of fracture toughness during welding. In this work, fracture toughness is expressed by J-integral. There are many experimental methods to obtain the critical toughness JIC but they are impractical for our investigation during phase transformation. That is the reason why we have proposed a method coupling mechanical tests, digital image correlation and finite element simulation. The fracture tests are implemented on pre-cracked single edge notched plate sample which is easy for machining and heat conduct during phase transformation. The tests are conducted at different temperatures until rupture. Digital image correlation gives us the displacement information on every sample. Each test is then simulated by finite element where the fracture toughness is evaluated by the method G-Theta at the crack propagation starting moment found by potential drop method and digital image correlation technical. Two materials have been studied, 15Cr-5Ni martensitic precipitation hardening stainless steel and 16MND5 ferritic low carbon steel. For these two materials, different test temperatures were chosen before, during and after phase transformation for testing and failure characterization of the mechanical behavior. Investigation result shows that metallurgical phase transformation has an influence on fracture toughness and further crack propagation. For 15-5PH, the result of J1C shows that the as received 15-5PH has higher fracture toughness than the one at 200 C. The toughness is also higher than the original material after one cycle heat treatment probably due to some residual austenite. Meanwhile, pure austenite 15-5PH at 200 C has higher fracture toughness than pure martensitic 15-5PH at 200 C. For 16MND5, the result also proves that the phase transformation affects fracture toughness. The as received material has bigger J1C than the situation where it was heated

  6. Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

    Science.gov (United States)

    Ludolph, Albert C; Bendotti, Caterina; Blaugrund, Eran; Hengerer, Bastian; Löffler, Jean-Philippe; Martin, Joanne; Meininger, Vincent; Meyer, Thomas; Moussaoui, Saliha; Robberecht, Wim; Scott, Sean; Silani, Vincenzo; Van Den Berg, Leonard H

    2007-08-01

    A transgenic animal model for anterior horn cell loss was established in 1994. This model is based on the insertion of a high copy number of disease-causing human Cu/Zn SOD mutations into the intact mouse genome. It serves to establish hypotheses for the pathogenesis of anterior horn cell death, but also to test potential pharmacological approaches to therapy in human ALS. Today, more than 100 -- published and unpublished -- compounds have been tested in this animal model, a large part of them being reported as successful. However, it proved to be difficult to translate these therapeutic successes in the animal model into human trials. Also, a number of disease-modifying strategies were difficult to reproduce, even by the same group. On the other hand, the step from mice to men means a huge investment for the sponsors of clinical trials and the scientific community. Therefore, establishment of standard methods for drug testing in ALS models is mandatory. In this workshop, clinical and preclinical researchers established in the field of ALS/MND met in Holland in March 2006 in order to establish guidelines for the community for drug testing in mouse models.

  7. Micro-mechanical analysis and modelling of the behavior and brittle fracture of a french 16MND5 steel: role of microstructural heterogeneities

    International Nuclear Information System (INIS)

    Mathieu, J.Ph.

    2006-10-01

    Reactor Pressure Vessel is the second containment barrier between nuclear fuel and the environment. Electricite de France's reactors are made with french 16MND5 low-alloyed steel (equ. ASTM A508 Cl.3). Various experimental techniques (scanning electron microscopy, X-ray diffraction...) are set up in order to characterize mechanical heterogeneities inside material microstructure during tensile testing at different low temperatures [-150 C;-60 C]. Heterogeneities can be seen as the effect of both 'polycrystalline' and 'composite' microstructural features. Interphase (until 150 MPa in average between ferritic and bainitic macroscopic stress state) and intra-phase (until 100 MPa in average between ferritic orientations) stress variations are highlighted. Modelling involves micro-mechanical description of plastic glide, mean fields models and realistic three-dimensional aggregates, all put together inside a multi-scale approach. Calibration is done on macroscopic stress-strain curves at different low temperatures, and modelling reproduces experimental stress heterogeneities. This modelling allows to apply a local micro-mechanical fracture criterion for crystallographic cleavage. Deterministic computations of time to fracture for different carbides random selection provide a way to express probability of fracture for the elementary volume. Results are in good agreement with hypothesis made by local approach to fracture. Hence, the main difference is that no dependence to loading nor microstructure features is supposed for probability of fracture on the representative volume: this dependence is naturally introduced by modelling. (author)

  8. Micro-mechanical analysis and modelling of the behavior and brittle fracture of a french 16MND5 steel: role of microstructural heterogeneities; Analyse et modelisation micromecanique du comportement et de la rupture fragile de l'acier 16MND5: prise en compte des heterogeneites microstructurales

    Energy Technology Data Exchange (ETDEWEB)

    Mathieu, J.Ph

    2006-10-15

    Reactor Pressure Vessel is the second containment barrier between nuclear fuel and the environment. Electricite de France's reactors are made with french 16MND5 low-alloyed steel (equ. ASTM A508 Cl.3). Various experimental techniques (scanning electron microscopy, X-ray diffraction...) are set up in order to characterize mechanical heterogeneities inside material microstructure during tensile testing at different low temperatures [-150 C;-60 C]. Heterogeneities can be seen as the effect of both 'polycrystalline' and 'composite' microstructural features. Interphase (until 150 MPa in average between ferritic and bainitic macroscopic stress state) and intra-phase (until 100 MPa in average between ferritic orientations) stress variations are highlighted. Modelling involves micro-mechanical description of plastic glide, mean fields models and realistic three-dimensional aggregates, all put together inside a multi-scale approach. Calibration is done on macroscopic stress-strain curves at different low temperatures, and modelling reproduces experimental stress heterogeneities. This modelling allows to apply a local micro-mechanical fracture criterion for crystallographic cleavage. Deterministic computations of time to fracture for different carbides random selection provide a way to express probability of fracture for the elementary volume. Results are in good agreement with hypothesis made by local approach to fracture. Hence, the main difference is that no dependence to loading nor microstructure features is supposed for probability of fracture on the representative volume: this dependence is naturally introduced by modelling. (author)

  9. A micro-mechanical analysis and an experimental characterisation of the behavior and the damaging processes of a 16MND5 pressure vessel steel at low temperature; Etude micromecanique et caracterisation experimentale du comportement et de l'endommagement de l'acier de cuve 16MND5 a basses temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Pesci, R

    2004-06-15

    As part of an important experimental and numerical research program launched by Electricite De France on the 16MND5 pressure vessel steel, sequenced and in-situ tensile tests are realized at low temperatures [-196 C;-60 C]. They enable to associate the observation of specimens, the complete cartography of which has been made with a scanning electron microscope (damaging processes, initiation and propagation of microcracks), with the stress states determined by X-ray diffraction, in order to establish relevant criteria. All these measurements enable to supply a two-scale polycrystalline modeling of behavior and damage (Mori-Tanaka/self-consistent) which is developed concurrently with the experimental characterization. This model proves to be a very efficient one, since it correctly reproduces the influence of temperature experimentally defined: the stress state in ferrite remains less important than in bainite (the difference never exceeds 150 MPa), whereas it is much higher in cementite. The heterogeneity of strains and stresses for each crystallographic orientation is well rendered; so is cleavage fracture normal to the {l_brace}100{r_brace} planes in ferrite (planes identified by electron back scattered diffraction during an in-situ tensile test at -150 C), which occurs sooner when temperature decreases, for a constant stress of about 700 MPa in this phase. (author)

  10. Microstructure and Ductility-Dip Cracking Susceptibility of Circumferential Multipass Dissimilar Weld Between 20MND5 and Z2CND18-12NS with Ni-Base Filler Metal 52

    Science.gov (United States)

    Qin, Renyao; Duan, Zhaoling; He, Guo

    2013-10-01

    The large circumferential multipass dissimilar weld between 20MND5 steel and Z2CND18-12NS stainless steel welded with FM52 filler material was investigated in terms of the diluted composition, the grain boundary precipitation, and the ductility-dip cracking (DDC) susceptibility of the weld. The diluted composition of the weld is composed of 37 to 47 pct Ni, 21 to 24 pct Cr, and 28 to 40 pct Fe, which are inhomogeneous along the depth and over the width of the deep weld. The carbon content has a distribution in the region of the surface weld from a high level (~0.20 pct) in the zone near 20MND5 steel to a normal level (~0.03 pct) in the zone near Z2CND18-12NS stainless steel. The carbon distribution is corresponding to the grain boundary carbides. The minimum threshold strains for DDC occur in the temperature range of 1223 K to 1323 K (950 °C to 1050 °C), which are 0.5, 0.35, and 0.4 pct for the root weld, middle region, and the surface weld, respectively. The dissimilar weld has the largest susceptibility to the DDC compared to the filler metal 52 and the Inconel 690.

  11. The synthesis and crystal structures of the first rare-earth alkaline-earth selenite chlorides MNd10(SeO3)12Cl8 (M=Ca and Sr)

    International Nuclear Information System (INIS)

    Berdonosov, P.S.; Olenev, A.V.; Dolgikh, V.A.; Lightfoot, P.

    2007-01-01

    Two new alkaline-earth Nd selenite chlorides MNd 10 (SeO 3 ) 12 Cl 8 (M=Ca, Sr) were obtained using crystal growth from alkaline-earth chloride melts in quartz tubes. These new compounds crystallize in the orthorhombic system in space group C cca (no. 68). The compounds were studied by energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction. It was shown that both compounds adopt the same structure type, constructed by complex [M 11 (SeO 3 ) 12 ] 8+ slabs separated by chloride anion layers perpendicular to the longest cell parameter. The SeO 3 groups show a pyramidal shape and may be described as SeO 3 E tetrahedra. Such SeO 3 groups decorate the Nd-O skeletons forming the [M 11 (SeO 3 ) 12 ] 8+ slabs. - Graphical abstract: Two new alkaline-earth Nd selenite chlorides MNd 10 (SeO 3 ) 12 Cl 8 (M=Ca, Sr) were synthesized. These structures are constructed by [M 11 (SeO 3 ) 12 ] 8+ slabs separated by chloride anion layers

  12. Vananemise vastu toiduga / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2012-01-01

    Toitumisteaduste magistri David Wolfe poolt soovitatud vananemise märke aeglustavatest ning pidurdavatest supertoitudest ja toidulisanditest: kasekäsn e must pässik, reishi-seen,kakao, assai, avokaado, brokoli, sidrun, õun, õunamahl, õunasiider, õunaäärikas, maka e mugulkress, goji ja mooruspuu marjad; vetikad klorella ja spirulina; toidulisandid EDTA – etüleendiamiin-tetraäädikhape (Ethylenediaminetetraacetic acid), humiin- või fulvohape, MSM – metüülsulfonüülmetaan

  13. Innovatsiooniosak tuleb appi / Marika Popp

    Index Scriptorium Estoniae

    Popp, Marika

    2008-01-01

    Innovatsiooniosak ( innovation vouchers) kujutab endast kinkekaarti ettevõtjale, selle alusel avaneb eriti väike- ja keskmise suurusega ning seni vähe või üldse mitte teadus- ja arendustööga kokku puutunud ettevõtteil saada esimene kogemus ning tekitada juurdepääs teadmiste allikale

  14. Kergitajad, paksendajad, tarretajad / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2012-01-01

    Nii looduslikest (alginiinhape, guarkummi e guarjahu, jaanileivapuujahu, karrageen, ksantaankummi, kummiaraabik, pektiin) kui tööstuslikult toodetud paksendajatest, tarretajatest ja kergitusainetest

  15. Kasvukeskkond ja andekus / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika, 1949-

    2001-01-01

    Imikute ja väikelastega läbi viidud longituuduuringu eesmärgiks oli välja selgitada kasvukeskkonna faktorite mõju väikelapse intellekti arengule. Töös osalesid professorid M. Vikat, V. Kolga, teadur A. Vikat, doktor E. Tomberg, magistrandid M. Laane, K. Nugin ja I. Tuisk ning V. Vallner ja A. Veber

  16. Arenguindeks = Development index / Marika Kivilaid

    Index Scriptorium Estoniae

    Kivilaid, Marika

    2005-01-01

    Kokkuvõte kohalike omavalitsusüksuste arenguindeksi, mis on kolme näitaja (ettevõtete realiseerimise netokäive elaniku kohta, üksikisiku tulumaksu laekumine elaniku kohta, registreeritud töötuse määr) pingeridade kohapunktide summa, arvutamise tulemustest

  17. Sukeldumisharjutused prantslaste fotopeol / Marika Alver

    Index Scriptorium Estoniae

    Alver, Marika

    2006-01-01

    37. fotofestivalist Arles'is Prantsusmaal, mille peakuraatoriks oli fotograaf ja kineast Raymond Depardon. Näitusel on esitatud tema vanade sõprade David Angeli, Guy Le Querrec'i, Jean Gaumy ja David Burnetti töid, aga ka kaasaegset ühiskonda peegeldavate fotograafide Gilles Leimdorferi, Philippe Chanceli, Olivier Jobardi jt töid

  18. Kivid sinu sees / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Sapi- ja neerukivide tekke põhjustest, ravist nii tavameditsiini kui ka Steineri poolt loodud antroposoofilise meditsiini vahenditega ning mida saab teha, et kividest hoiduda. Nõuannavad Ida-Tallinna Keskhaigla kirurgid Rein Lumiste ja Toomas Tamm ning perearstikeskuse Medicum perearst Pille Soone

  19. Investigation of the high temperature behaviour of an unsteady crack growth in 16MND5 steel and application to the calculation of vessel bottom failure in case of severe accident

    International Nuclear Information System (INIS)

    Tardif, N.

    2009-01-01

    This research thesis deals with the prediction of the failure of a pressurized water reactor under an accidental thermo-mechanical loading. This study is based on tests performed on an instrumented mock-up and on the comparison of experimental results obtained on two different 16MND15 steel grades with numerical simulation results. The test model is a tube submitted to tension and inner pressure. Temperatures, strains and pressure are measured and images are acquired by two rapid digital cameras and an infrared camera. Crack initiation and propagation conditions are acquired. Simulations are performed using finite elements and the ABAQUS code. Crack initiation and growth are modelled by a cohesive area method. Strain rates are also studied

  20. Reis kosmosesse : [Floating-kambrist] / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Ameerika psühholoogi John C. Lilly poolt kasutusele võetud Floating-kambrist ehk hõljumisvannist, mis aeglustab ajulaineid ning seeläbi aitab vähendada lihaspinget, stressi, ärevust, peavalusid, vererõhku ning parandada und, selgroo- ja kaelavigastusi, suurendada loovust ja heaolu jne

  1. Liival etenduvad vangide elulood / Marika Raiski

    Index Scriptorium Estoniae

    Raiski, Marika

    2000-01-01

    Merle Karusoo 12 vangi elulugu käsitlevast dokumentaallavastusest "Save Our Souls", mis tuleb ettekandele 31. mail Tallinnas Liiva keskuses. Etenduses osalevad Vene Draamateatri ja Narva Teatri Ilmarine näitlejad. Eestvedajaks on VAT Teater

  2. Siledaks ja saledaks skalpellita / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2013-01-01

    Eestis enamlevinud protsetuuridest kortsude silumiseks, naha noorendamiseks, keha salendamiseks ja juuste kohendamiseks: botox-süstid, hüaloroonhappesüstid, fotonoorendus, lasernoorendus, velashape tselluliidihooldus, kavitatsioon, tahe magic botox vananemisvastane juuksehooldus

  3. Pensionitõus ja pangad / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2006-01-01

    Ilmunud ka: Videvik 16. märts lk. 3, Vali Uudised 17. märts lk. 2, Meie Maa 18. märts lk. 2, Virumaa Teataja, Pärnu Postimees, Harjumaa, Põhjarannik, Severnoje Poberezhje 21. märts lk. 11,19,7,2,5, Nädaline 28. märts lk. 3. 1. apr. viiakse läbi teine uue valitsuse erakonnaline pensionitõus. Pangad on laenuandmise vanusepiirangut kergitanud 10 aasta võrra

  4. Appi, pea lõhub / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    Vestlusest Ida-Tallinna Keskhaigla neuroloogiaosakonna juhataja ja peavalukeskuse rajaja dr Toomas Toomsooga ning Aurea ajurveeda- ja massaažikeskuse ajurveedaarsti Aleksandr Dreljoviga peavalust: peavalu ravi india ajurveeda seisukohalt, läänemeditsiini peavalu tüübid ning nende ravi jne

  5. "Ravimiohutus - rahva tervise kaitseks" / Marika Gordon

    Index Scriptorium Estoniae

    Gordon, Marika

    2010-01-01

    Ajakirja “Apteeker” ja Eesti Akadeemilise Farmaatsia Seltsi kevadkonverentsi ettekandeid kommenteerivad MEDA Pharma SIA Eesti juhataja Anu Adermann, Apteekide infotehnoloogia OÜ juhataja Siim Uibokand, Pärnu Lõvi apteegi juhataja Kärt Kambla ja Eesti Haigekassa ravimiosakonna peaspetsialist Erki Laidmäe

  6. Alaealise õigus abordile / Marika Žmenja

    Index Scriptorium Estoniae

    Žmenja, Marika

    2014-01-01

    1. jaanuaril 2009 jõustusid raseduse katkestamise ja steriliseerimise seaduse muudatused, mille järgi alaealise raseduse katkestamiseks on vaja lisaks tema enda sooviavaldusele saada ka eestkostja nõusolek või kohtu luba. Alaealise õigusest eraelu kaitsele inimõiguste ja põhivabaduste kaitse konventsiooni ja Euroopa Kohtu praktika alusel

  7. Eesti tervishoid - Euroopa punane latern / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2005-01-01

    Ilmunud ka: Nädaline 3. märts lk. 4, Elva Postipoiss 5. märts lk. 4, Valgamaalane 12. märts lk. 2, Hiiu Leht 8. apr. lk. 2. Autori sõnul on Eesti tervishoiu rahastamise poolest Euroopas viimasel kohal, kulutades selleks alla 5% SKP-st

  8. Eesti seadused kolivad igaveseks internetti / Marika Seppius

    Index Scriptorium Estoniae

    Seppius, Marika, 1959-

    2005-01-01

    1. jaanuarist 2007 on elektrooniline Riigi Teataja ainus ametlik väljaanne. Sama ka: Põhjarannik 26. juuli 2005, lk. 2 ; Virumaa Teataja 28. juuli 2005, lk. 7 ; Võrumaa Teataja 30. juuli 2005, lk. 2 ; Sakala 4. aug. 2005, lk. 2 ; Pärnu Postimees 4. aug. 2005, lk. 15 ; Vooremaa 4. aug. 2005, lk. 2 ; Valgamaalane 11. aug. 2005, lk. 2 ; Koit 13. aug. 2005, lk. 6

  9. Tõde pensionide kojukande kohta / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2008-01-01

    Pensionide kojukande muudatustest ning vastuseks 28. oktoobri ajalehes ilmunud Heljo Pikhofi artiklile "Pensioniraha jõuab igaüheni". Ilmunud ka Harju Ekspress 7. nov. 2008, lk. 9 ; Põhjarannik 6. nov. 2008, lk. 2 ; Võrumaa Teataja 8. nov. 2008, lk. 2 ; Pärnu Postimees 6. nov. 2008, lk. 11 ; Vooremaa 13. nov. 2008, lk. 2 ; Virumaa Teataja 21. nov. 2008, lk. 11, pealkiri kujul: veel pensionide kojukandest ; Sõnumitooja 12. nov. 2008, lk. 2

  10. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, B

    2001-07-15

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

  11. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, B

    2001-07-15

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

  12. Naistearstide ja neuroloogide kokkusaamine pakkus osapooltele suurt huvi / Marika Gordon

    Index Scriptorium Estoniae

    Gordon, Marika

    2010-01-01

    Eesti Naistearstide Seltsi ja L. Puusepa nimelise Eesti Neuroloogide ja Neurokirurgide Seltsi ühiskoosolekul kõneldi naiste ja meeste neurobioloogilistest iseärasustest, seksuaaleluhäiretest, rasedusaegsetest peavaludest, epilepsia ravist naistel ja sünnitusabist

  13. HIV-infektsioon on seotud nakkuslike haigustega / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2004-01-01

    TÜ arstiteaduskonna täienduskeskuse kolmepäevasel kursusel Tallinnas olid kõneks HIV-nakkuse seosed bakteriaalsete ja viiruslike nahahaigustega, parasitaarsete ja seenhaigustega, samuti nakkushaiguste ja seksuaalsel teel edasiantavate haigustega

  14. Valitsus hämab liikluskindlustuse seadusega / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2004-01-01

    Ilmunud ka: Vooremaa, 12. veebr. 2004, lk. 2; Elva Postipoiss, 14. veebr. 2004, lk. 4; Meie Maa, 20. veebr. 2004, lk. 2; Vali Uudised, 20. veebr. 2004, lk. 2; Põhjarannik, 21. veebr. 2004, lk. 2; Severnoje Poberezhje, 21. veebr. 2004, lk. 2; Kesknädal, 25. veebr. 2004, lk. 2; Valgamaalane, 16. märts 2004, lk. 6. Kriitiliselt liikluskindlustuse seaduse eelnõust. Liikluskindlustuse seaduse eelnõu arutelust Riigikogus

  15. Aino Ugaste doktoritööst / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika

    2005-01-01

    12. veebruaril 2005. aastal kaitses TPÜ dotsent Aino Ugaste Soomes Jyväskylä Ülikoolis kasvatusteaduste doktori kraadi teemal "The Childs' play world at home and the mothers' role in the play - Laste mängumaailm kodus ja ema roll mängus"

  16. Maksude äkktõus ja hinnaralli / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2007-01-01

    Ilmunud ka: Vali Uudised, 13. juuni 2007, lk. 2; Meie Maa, 20. juuni 2007, lk. 2; Severnoje Poberezhje, 20. juuni 2007, lk. 2; Virumaa Teataja, 21. juuni 2007, lk. 11; Põhjarannik, 21. juuni 2007, lk. 2; Sõnumitooja, 22. juuni 2007, lk. 2; Harjumaa, 26. juuni 2007, lk. 2; Hiiu Leht, 26. juuni 2007, lk. 2; Pärnu Postimees, 27. juuni 2007, lk. 15; Vooremaa : Kallaste Linna Leht, 21. juuli 2007, lk. 2. Autor kritiseerib valitsuskoalitsiooni maksupoliitikat

  17. EBSCO infopäev Tallinnas / Marika Meltsas

    Index Scriptorium Estoniae

    Meltsas, Marika

    2008-01-01

    16. aprillil 2008 toimus Tallinnas EBSCO (Elton B. Stephens Company) infopäev, kus maailma suurim elektrooniliste ja trükiajakirjade vahendaja tutvustas oma tooteid ja teenuseid Eesti raamatukogudele. Kommentaar korraldajalt Tiina Nurmilt

  18. Siddhameditsiin : hästi hoitud saladus / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2013-01-01

    Vestlusest Šveitsis elava siddhatohtri Gitanjali Azariah-Theleniga Indias elavate tamilite filosoofiast kui ka loodusmeditsiinist, mille õpetused on kirja pandud Tamil Nadu osariigi templites asuvates iidsetes tamilikeelsetes ürikutes

  19. Korruptsioon mittetulundusliikumises / Marika K Arendi Elita von Wolsky

    Index Scriptorium Estoniae

    Arendi Elita von Wolsky, Marika K.

    2001-01-01

    Eesti Mittetulundusühingute ja Sihtasutuste Liidus toimunud erakorralisest koosolekust, kus arutati artikli autori avaldusi, mis olid ajendatud tema avalikus kirjas esitatud küsimustest Mall Hellamile. Vt. samas: Kesknädal, 5. dets. 2001, lk. 9

  20. Rahvusvaheline üldmeditsiini kongress oli Eestis esmakordselt / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2007-01-01

    8. detsembril peeti Tallinnas rahvusvahelist üldmeditsiini kongressi, kus osalesid mitmete erialade arstid. Kongressil käsitletud teemad - südame-veresoonkonnahaiguste varajane diagnostika, söömisharjumused, metabolism, hüpertoonia, erektsioonihäired, depressioon, 2. tüüpi diabeet ja oftalmoloogia

  1. Lionsi asepresident kiitis Eesti "lõvisid" / Marika Milve

    Index Scriptorium Estoniae

    Milve, Marika, 1968-

    1995-01-01

    Lions klubi Eestis. Vt. ka Meie Maa "Lionsite maailma-assotsiatsiooni teine asepresident Augustino Solivo külastas Saaremaad" 8- juuni, lk. 1, Oma Saar "Augustino Soliva: tavaliselt oskavad inimesed võtta, kuid ei oska anda" 7. juuni, lk. 3

  2. Ulila perearst jääb alles / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2006-01-01

    Riigikogu sotsiaalkomisjoni liige juhtumist, kus Puhja vallavalitsus kavatses Ulilas perearsti koha kaotada, aga parlamendiliikme ja sotsiaalministeeriumi sekkumisel saab Ulila perearst oma tööd jätkata. Sotsiaalministeeriumis valminud seaduseelnõust, mis ei kohusta perearsti olema ettevõtja

  3. Tähelepanu keskmes on viiruslik hepatiit / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2008-01-01

    Ülemaailmsel hepatiidipäeval 19. mail korraldasid Eesti Gastroenteroloogide Selts (EGS) ja Roche Eesti OÜ meediakanalite esindajatele ümarlaua, et aidata teadvustada C-hepatiidi ohtu, testimis- ja ravivõimalusi Eestis

  4. Richard Avedon ja Annie Leibovitz laulsid kaanonit / Marika Alver

    Index Scriptorium Estoniae

    Alver, Marika

    2008-01-01

    Richard Avedoni (1923-2004) retrospektiivnäitusest (fotod aastatest 1946-2004) kuraator Helle Crenzien (Lousiana Kaasaegse Kunsti muuseum Taanis), millega kaasnes ka Helen Whitney film "Richard Avedon : darkness and light" ja Annie Leibovitzi (1949) suurprojektist "A photographer's life 1990-2005" Pariisis

  5. TEH võrgustik - viis aastat Eestis / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2005-01-01

    Eestis on tervist edendavate haiglate (TEH) võrgustik tegutsenud juba viis aastat, sellega on liitunud 22 haiglat. Tänavust konverentsi peeti teemal "Tervise edendamine ja kvaliteedi tagamine haiglas: standardid ja praktika"

  6. Kaubakategooriate juhtimine annab konkurentide ees eelise / Marika Merilai

    Index Scriptorium Estoniae

    Merilai, Marika

    2008-01-01

    Tootekategooriate või ka kaubakategooriate juhtimine on ettevõtte äristrateegia, mis võimaldab jaekaubandusettevõttel saavutada konkurentidest paremaid tulemusi. Kanada turundusprofessori Brent McKenzie sõnul on kaubakategooriate juhtimine keeruline, kuna pole olemas ühte standardset lahendust, kuidas ettevõttes kategooriate juhtimist teostada. Skeem: Kaubakategooriate juhtimise eesmärgid. Kommenteerib ASi A-Selver sortimendijuht Agi Metsandi

  7. Dislocation structures in 16MND5 pressure vessel steel strained in uniaxial tension

    Czech Academy of Sciences Publication Activity Database

    Obrtlík, Karel; Robertson, Ch.; Marini, B.

    2005-01-01

    Roč. 342, - (2005), s. 35-41 ISSN 0022-3115 R&D Projects: GA AV ČR(CZ) 1QS200410502 Institutional research plan: CEZ:AV0Z20410507 Keywords : bainitic steels * dislocation structure * low temperature deformation Subject RIV: JG - Metallurgy Impact factor: 1.414, year: 2005

  8. Inimese papilloomiviiruse vastane vaktsiin imet ei tee, aga kaitseb siiski / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2006-01-01

    5. oktoobril korraldas ravimifirma Merck Sharp & Dohme koostöös erialaarstide, Eesti Vähiliidu ja Quattromediga ajakirjanikele ümarlaua, kus räägiti emakakaelavähi põhjustest ja ravist, HPV tüüpidest, nakatumis- ja kaitsemehhanismidest ning uuest Eesti turule jõudvast vaktsiinist

  9. Tammsaare-aastat ilmestavad ka raamatud / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika, 1952-

    2008-01-01

    Tammsaare muuseumis esitleti kahte raamatut: Tammsaare, Anton Hansen. Siin mägi, seal mägi... Anton Hansen Tammsaare oma koduloodusest : fotoalbum (koostanud Ann Marvet. Tallinn : Huma, 2008) ja Liivak, Age-Li. Tammsaare kirjanduspreemia laureaadid Hugo Hiibuse sulega. (Türi : Saarakiri, 2008)

  10. Archaeological excavations at Viltina - a viking age harbour site and meeting place / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika, 1968-

    2007-01-01

    2006 jätkusid kaevamised Viltina viikingiaegsel sadamakohal, millega oli alustatud juba 2004. aastal. Kaevati läbi 327,25 m2. Suuremas osas kaevandites paljandunud kiht on vaieldamatult asulakiht. Viltina asulakihiga aladel leidus tavapärasest asulakihist tunduvalt rohkem metall-leide. Leidudest. Tõenäoliselt oli sadamakoht kasutusajal piiratud taraga

  11. Intellekt ja selle areng imiku- ja väikelapseeas / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika, 1949-

    1998-01-01

    Kolm ajaloolist lähenemist intellekti uurimisele. Nancy Bayley poolt 1969.a. välja töötatud esimene põhjalikum väikelaste ja imikute intellekti uurimismetoodika - Bayley Imikute Arengu Skaala; psühhomeetriline lähenemine, J. Piaget kognitiivse arengu teooria

  12. Bakterite Miss Marple = The Miss Marple of bacteria / Marika Mikelsaar ; interv. Evelin Kivilo

    Index Scriptorium Estoniae

    Mikelsaar, Marika, 1938-

    2008-01-01

    Intervjuu Tartu Ülikooli professori, probiootilise piimhappebakteri ME-3 avastajaga, kes pälvis president Toomas Hendrik Ilveselt Eesti Vabariigi 90. aastapäeva puhul Valgetähe III klassi teenetemärgi

  13. Excavations on the Coasts of Prehistoric and Medieval Saaremaa / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika, 1968-

    2006-01-01

    Viltina võimaliku sadamakoha kaevamistest. Leiti järjekordne 11. sajandi leiukompleks, seekord tüüpilistest Saaremaa naise ehetest. Pällamõisas on inimtegevus saanud alguse ilmselt I aastatuhande keskel, mil see paiknes otse mererannal. Inimtegevus Pällamõisas lakkas ilmselt keskaja alguses. 16. sajandi algul rajati sellele kohale hoonekompleks, mis juba 17. sajandil hüjati. Proovikaevamistest Tammese asulakohal

  14. The mortuary house at Lepna on southern Saaremaa / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika

    2004-01-01

    Kaevamistest Lepna Katkuauguks nimetatud matusekohal. Surnumaja ümbritsenud kultuurmaastikust, surnumaja jäänustest, matustest. Lepna surnumaja markeerib silmnähtavaid muudatusi Saaremaa matmiskombestikus 5. - 6. sajandil

  15. 400 miljoni eurone programm toetab innovaatilisi ettevõtteid / Marika Roomere

    Index Scriptorium Estoniae

    Roomere, Marika

    2007-01-01

    2007. aasta sügisel ellu kutsutud Euroopa ettevõtluse toetusprogrammist Eurostars, mille raames toetatakse keskmise suurusega ja väikeettevõtteid 400 miljoni euroga rahvusvahelise teadus- ja arendustegevusega tegelemiseks. Lisa: Mis on Eurostarsi programm?

  16. Rain Jõgi : Kehtivat trendi on keeruline murda / Rain Jõgi ; interv. Marika Kusnets

    Index Scriptorium Estoniae

    Jõgi, Rain

    2006-01-01

    TÜ kliinikumi kopsukliiniku juhataja kommenteerib European Community Respiratory Health Survey rahvusvahelist uuringut ja eestlaste suitsetamisharjumusi hingamisteede haiguste riskiteguritena üldisemas plaanis

  17. Leedu ettevõtteid ahvatleb Eesti turg / Gerli Ramler, Marika Roomere

    Index Scriptorium Estoniae

    Ramler, Gerli

    2007-01-01

    Mitmed Leedu ettevõtted on juba edukalt Eesti turule sisenenud ning oodata on uusi tegijaid. Leedu pitsarestoranide keti Cili ja Double Coffee Estonia plaanidest. Vt. samas: Toiduliidu juhataja Sirje Potisepp. Turg on avatud kõigile; Intervjuu Raimondas Useckasega

  18. Rahvakunst Marika ja Heinz Valgu kollektsioonist : Heie Treier soovitab / Heie Treier

    Index Scriptorium Estoniae

    Treier, Heie, 1963-

    2000-01-01

    12. märtsini Tarbekunstimuuseumis avatud näitusest, mille on kujundanud Heinz Valk. Soovitatakse külastada Kunstihoones Anu Juuraku näitust 'Tsoon 2', kus tegeldakse identiteedi probleemidega kõrgtehnoloogilisel tasandil.

  19. Noor näitleja otsib rollides ennast / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika

    2006-01-01

    Tantsuõpetaja Helmi Tohvelmani nimelise liikuvaima näitleja preemia võttis vastu näitleja Tambet Tuisk, Järvamaa maakooli edukaima õpilase preemia aga Annely Tank, kes õpib Koigi Põhikooli 9. klassis

  20. Maagiline Matrix - muutuste võti / Marika Makarova ; kommenteerinud Ainar Leppik

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    USA kiropraktiku Richard Bartletti loodud Matrix Energetics tehnikate alusl Ainar Leppiku poolt loodud Maagilise Maatriksi meetodist, mis õpetab muutuste toomist oma ellu. Vestlustest Maagilise Maatriksi õpetajatega

  1. Vest-Wood pürgib Balti turule / Marika Tomberg

    Index Scriptorium Estoniae

    Tomberg, Marika

    2004-01-01

    Ilmunud ka: Äripäev : Eesti Edukamad Ettevõtted : Maakondlikud edetabelid Top 100, 26. nov. 2004, lk. 15. TOP-i 1. koht. Uksetootja Vest-Woodi konkurentsieeliseks on väga hea töökorraldus. Diagramm

  2. Loodusesõber / Maria Martinez Ros ; küsis Marika Makarova

    Index Scriptorium Estoniae

    Martinez Ros, Maria

    2012-01-01

    Intervjuu Tallinnas ja Lilleorus tantsuteraapia kursusi andva mehhiklanna Maria Martinez Rosiga, kes on õppinud permakultuuri disaini, humanistliku psühholoogiat, tanatoloogiat, Feldenkraisi meetodit, tema vaadetest jätkusuutlikule elamise viisile

  3. Parim proosalugeja köitis küpsusega / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika, 1952-

    2008-01-01

    Toimus viies üle-eestiline proosalugemine "Hansenist Tammsaareni". Mõtteid võistulugemise kohta avaldavad konkursi algataja Enda Trubok, Järva maavalitsuse haridus- ja kultuuriosakonna peainspektor Anne Viljat, Eesti emakeeleõpetajate seltsi esimees Piret Järvela, žürii esimees Iivi Lepik, konkursil võistelnud Merilin Kulpsoo. Peavõidu sai Sabine Liias, V-VII klasside arvestuses läks I koht Sabine Liiasele, II koht Kristian Käreskile, III koht Kristiina Orasele. VIII-IX arvestuses läks I koht Katriin Altementile, II koht Indrek Jõele, III koht Linda Randojale. X-XII klasside arvestuses võitis Kaire Olesk, II koha saii Sten-Robert Pullerits ning III koha Katrin Ojalill

  4. Audentese koolid kolivad väärikatesse majadesse / Marika Karo

    Index Scriptorium Estoniae

    Karo, Marika

    2002-01-01

    Tartu linnavalitsus otsustas 9. mail 2002.a. müüa Tartus Puiestee tänaval asuva ajaloolise koolikompleksi ASile Audentes, kes kavatseb kinnistul olevatest kahest muinsuskaitse alla kuuluvast koolimajast, tööõpetuse majast, abihoonetest ja spordiplatsist välja arendada campus-tüüpi tänapäevase koolide kompleksi. Hooneid hakkavad kasutama Audentes Mainor Ülikooli Tartu filiaal ja alg- ja põhiharidust pakkuv Audentese Erakool. Koolihoonete kompleksi ajaloost

  5. Tööandjate unistuste seaduse autorid olid tegelikult sotsid / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2008-01-01

    Uue töölepingu seaduse eelnõust. Ilmunud ka Virumaa Teataja 29. jaan. 2008, lk. 11 ; Hiiu Leht 29. jaan. 2008, lk. 2 ; Pärnu Postimees 29. jaan. 2008, lk. 15 ; Vali Uudised 30. jaan. 2008, lk. 2, pealkiri kujul: uus orjaaeg ; Meie Maa 29. jaan. 2008, lk. 2 ; Põhjarannik 30. jaan. 2008, lk. 2 ; Lääne Elu 29. jaan. 2008, lk. 2 ; Elva Postipoiss 2. veeb. 2008, lk. 4, pealkiri kujul: Kas uus orjaaeg? ; Kesknädal 6. veeb. 2008, lk. 2 ; Vooremaa 14. veeb. 2008, lk. 2

  6. Precarisation, Social Work, and Social Ethics

    DEFF Research Database (Denmark)

    Zeller, Jörg

    2011-01-01

    Prækarisering af arbejds- og livsforhold stiller forøgede krav til socialarbejde og stiller socialarbejdere for individuelt uløselige dilemmaer.......Prækarisering af arbejds- og livsforhold stiller forøgede krav til socialarbejde og stiller socialarbejdere for individuelt uløselige dilemmaer....

  7. Public health assessment for Freeway Sanitary Landfill, Burnsville, Dakota County, Minnesota, Region 5. CERCLIS No. MND038384004. Final report

    International Nuclear Information System (INIS)

    1993-01-01

    The Freeway Sanitary Landfill National Priorities List (NPL) site in Burnsville, Minnesota is situated in the Lower Minnesota River Valley. Shallow groundwater beneath the site is contaminated with low levels of volatile organic hydrocarbons and heavy metals. Under current conditions, no human exposures to site-related contaminants are known to occur at levels of health concern. Based on currently available information, the Minnesota Department of Health concludes that the site poses an indeterminate public health hazard under current conditions because exposure to volatile gases released to the air is possible, but cannot be evaluated from the very limited information available. There are also a few physical hazards on the site which pose a risk of accident or injury if trespassing occurs. Otherwise, there are no indications that people have been, or are being, exposed to site-related contaminants at levels that would be of health concern. The Agency For Toxic Substances and Disease Registry (ATSDR) Health Activities Recommendation Panel has evaluated the Freeway Sanitary Landfill Public Health Assessment for appropriate follow-up activities. The Panel has recommended that health education be considered to assist site workers in better understanding their potential for exposure to landfill gases

  8. 22 tundi tõde ja õigust Anton Hansen Tammsaare moodi / Risto Berendson, Marika Rajamäe

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2008-01-01

    30. okt. kirjutati Anton Hansen Tammsaare sünniaastapäeva puhul alla lepingule, mis toob Vargamäele maratonetenduse kogu "Tõe ja õiguse" põhjal. Etendus toimub 21.-22. juunini. Kommenteerib Ülo Tonts

  9. Elu- ja mõtterännakud, minemised ja saatmised / Kaljo Põllu ; interv. Jonathan Roper, Marika Alver

    Index Scriptorium Estoniae

    Põllu, Kaljo, 1934-2010

    2007-01-01

    Kaljo Põllu oma kunstiõpingutest, loomingust, tööst Tartu Ülikooli kunstikabineti juhatajana, käikudest soomeugrilaste juurde, soome-ugri ekpeditsioonide korraldamisest kunstiinstituudis, ekspeditsioonide mõjust üliõpilaste mõtteviisile ja kunstile, rühmitusest Ydi, soomeugrilisusest eemaldumisest. Leedsi ülikooli inglise filoloogia lektor Jonathan Rops on käinud koos EKA üliõpilastega ekspeditsioonidel 1998., 1999. ja 2003. aastal

  10. Eesti merovingi- ja viikingiaegsed rinnanõelad - võõrapärased ja omad / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika

    1997-01-01

    Artiklis käsitletakse Eesti merovingi- ja viikingiaegsete ehtenõelte tüpoloogiat ja kandmisviise. Vaatluse alla on võetud rõngaspeaga, kolmnurkpeaga ja varasemad kaksikristpeaga nõelad, mille dateeringut ja tüpoloogilist arengut on varasemaga võrreldes täpsustatud. Joonised, diagrammid, fotod

  11. Žürii kommenteerib Kultuurkapitali arhitektuuripreemiaid 2008 / Marika Lõoke, Laila Põdra, Liina Jänes... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Peapreemia: Markus Kaasik, Andres Ojari, Ilmar Valdur, Mihkel Tüür, Kalle Komissarov (Pärnu Keskraamatukogu hoone), tegevuspreemia: Maarja Kask, Ralf Lõoke, Neeme Külm, Ingrid Ruudi (projekt Gaasitoru 11. Veneetsia arhitektuuribiennaalil), aastapreemia: Maarja Kask, Ralf Lõoke, Karli Luik (Tartu Kesklinna Kooli juurdeehitus) ja Peep Jänes (Raudna Põhikooli spordihoone), sisearhitektuuri preemia: Tea Tammelaan, Malle Jürgenson, Krista Lepland, restaureerimispreemia: Mari Hammer, Tiiu Lõhmus, Helve Ilves, Villu Kadakas (Vanalinna Hariduskolleegiumi hoone)

  12. Gurmaanlus ruulib / Marika Makarova ; kommenteerinud Anu Tali, René Uusmees, Tõnis Siigur, Hannes Võrno, Dimitri Demjanov

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    Tulevikutoidu konverentsil Tallinnas esinenud kuulsate kokkade Albert Adria, Fergus Hendersoni ja Claus Meyeri kokakunsti lähtekohtadest ja mõistet gurmaanlus mõtestavad lahti tuntud Eesti inimesed ja kokad

  13. Feng shui väärtus on vaimujõus / Marika Tomberg ; komment. Lea Eermann, komment. Rein Weber

    Index Scriptorium Estoniae

    Tomberg, Marika

    1999-01-01

    Feng shui järgi korraldatud Lea Eermanni kodust Nõmmel. Feng shui- ja geobioloogia-alase nõustamisega tegelev arhitekt Rein Weber keskkonna mõjust tervisele, magamistoast. Enda ja maja kaitsmisest halbade mõjude eest. 10 illustratsiooni

  14. HIV-i võib nakatunud olla iga sajas täiskasvanud eestlane / Marika Raiski

    Index Scriptorium Estoniae

    Raiski, Marika

    2005-01-01

    Vt. ka Nädaline 27. sept., lk. 7. Vastavalt Maailma Terviseorganisatsiooni (WHO) ja UNAIDS-i hinnangule on Eestis hulgaliselt registreerimata HIV-juhte ning tegelikult võib HIV-nakatunuid olla juba iga sajas täiskasvanud Eesti elanik

  15. Mis muutub Eesti Kunstimuuseumi elus, rollis ja tähenduses, kui Kumu valmis on saanud? / Marika Valk

    Index Scriptorium Estoniae

    Valk, Marika

    2004-01-01

    EKMi filiaalidest jäävad edasi tegutsema Kadrioru lossi väliskunstimuuseum (koos Mikkeli muuseumiga), Niguliste muuseum, Adamson-Ericu muuseum, Kristjan Raua majamuuseum, juurde tuleb Kumu, tegevuse lõpetavad Rüütelkonna hoone ja kunstimuuseumi näitusepind Rotermanni soolalaos

  16. 3- ja 4-aastaste laste intellektuaalne areng erinevates kasvukeskkondades / Merit Laane, Kristina Nugin, Ingrid Tuisk, Marika Veisson

    Index Scriptorium Estoniae

    2001-01-01

    Uuringust, mille eesmärgiks oli selgitada, milline on 3- ja 4-aastaste laste intellektuaalne areng erinevates kasvukeskkondades. Uuringus osalesid longituuduurimuses osalenud lapsed, tavarühma lapsed ja Hea Alguse rühma lapsed

  17. Taotlused ja tulemus / Rein Tootmaa

    Index Scriptorium Estoniae

    Tootmaa, Rein

    2002-01-01

    Helle Karise kavandatava portreefilmide sarja "Contra mortem" esimene film "Dr. Andres Ellamaa" : operaatorid Peter Murdmaa ja Marko Piirsoo : monteerija Eero Karis : produtsendid Helle Karis ja Maret Hirtentreu : kasutatud Carl Orffi muusikat : Myth Film 2002

  18. Tere taas, XIII sajand! / Kalle Käsper

    Index Scriptorium Estoniae

    Käsper, Kalle, 1952-

    2002-01-01

    Helle Karise portreefilm alternatiivse meditsiini abil ravitsejast Aleksander Heintalust alias Vigala Sassist : operaatorid Ago Ruus, Peter Murdmaa ja Madis Mihkelsoo : monteerija Eero Karis : kostüümid Mare Raidmalt : kasutatud Veljo Tormise ballaadi "Raua needmine" : Myth Film 2002

  19. Doktor Ellamaa elutants / Linnar Priimägi

    Index Scriptorium Estoniae

    Priimägi, Linnar, 1954-

    2002-01-01

    Helle Karise kavandatava portreefilmide sarja "Contra mortem" esimene film "Dr. Andres Ellamaa" : operaatorid Peter Murdmaa ja Marko Piirsoo : monteerija Eero Karis : produtsendid Helle Karis ja Maret Hirtentreu : kasutatud Carl Orffi muusikat : Myth Film 2002

  20. "Metsluiged" re-edited / S. T.

    Index Scriptorium Estoniae

    S. T.

    2005-01-01

    Helle Karise 1987.a. Hans Christian Anderseni muinasjutu järgi valminud lastefilm "Metsluiged" linastus edukalt Taanis 16. NatFilmi festivalil Anderseni juubeliprogrammis ning ringleb nüüd rahvusvahelistel festivalidel

  1. Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients

    Czech Academy of Sciences Publication Activity Database

    Dorosh, Andriy; Teplá, O.; Žatecká, Eva; Děd, Lukáš; Kočí, K.; Pěknicová, Jana

    2013-01-01

    Roč. 11, č. 42 (2013) ISSN 1477-7827 R&D Projects: GA ČR(CZ) GAP503/12/1834 Institutional research plan: CEZ:AV0Z50520701 Keywords : Non-obstructive azoospermia * Human test es * Biopsy * Spermatogenesis * gene expression * ICSI Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.409, year: 2013

  2. Experimental study and simulation of transformation induced plasticity, and multiphase behaviour of the 16MND5 vessel steel under aniso-thermal multiaxial loading

    International Nuclear Information System (INIS)

    Coret, M.

    2001-01-01

    This work deals with the aniso-thermal multiphase behaviour of the French vessel steel and more specially about the transformation plasticity in the cases of multiaxial non-proportional loadings paths. The first part of this report is devoted to the presentation of a high temperature tension-torsion experimental device enable of obtaining a large range of cooling rate. This experimental set-up is used to explore the transformation plasticity under proportional or non-proportional loading paths, during austenitic, bainitic and martensitic transformations. The results of the tests are compared to the Leblond's model. In the last part, we propose a two-scale behaviour model in which the type of each phase behaviour can be different. This meso-model is finally used to simulate two real tests on structures. (author) [fr

  3. Söömishäirete spetsialistid kaesid uusi ravivõimalusi / Anu Järv, Kirsti Akkerman ; interv. Marika Kusnets

    Index Scriptorium Estoniae

    Järv, Anu

    2005-01-01

    Vestlus TÜ kliinikumi psühhiaatriakliiniku söömishäirete keskuse juhataja Anu Järvega ja kliinilise psühholoogi Kirsti Akkermanniga, kes osalesid 27.-30. aprillini Kanadas toimunud Academy of Eating Disorders konverentsil

  4. 1930. aastad Kaukaasias "Edasi" kolhoosis põllumehe silme läbi ja ajalehe "Edasi" veergudel. IV-V / Marika Mikkor

    Index Scriptorium Estoniae

    Mikkor, Marika, 1963-

    2006-01-01

    Kaukaasias Eesti-Rohuaias elanud August Rootsi päevaraamatust 1929-1942 aastatest ja Leningradis ilmunud ajalehe "Edasi" kirjutistest stalinlike repressioonide, kollektiviseerimise ja eestlaste eluolu kohta Kaukaasias

  5. Ilmub raamat viikingiajast Saaremaal / Pamela Talzi

    Index Scriptorium Estoniae

    Talzi, Pamela

    2017-01-01

    Saaremaal viikingiaega uurinud arheoloogi, Tallinna ülikooli humanitaarteaduste instituudi ajaloo, arheoloogia ja kunstiajaloo keskuse vanemteaduri Marika Mägi sulest ilmub raamat "Viikingiaegne Eesti"

  6. Uusi võimalusi pakkuv kasulik bakter / Villu Päärt, Siim Sepp

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2008-01-01

    Äsja võitis Lactobacillus fermentum ME-3 avastaja Tartu Ülikooli professor Marika Mikelsaar koos kolleegidega Soulis ülemaailmsel naisleiutajate konkursil kuldmedali. Bakterite omaduste uurimine jätkub. Marika Mikelsaare juhtimisel katsetati kõhutüüfusesse nakatatud hiirte peal, millist mõju avaldab see, kui antibiootikumi ravi ajal anda hiirtele ka ME-3 sisaldavat probiootikumi

  7. Kriisiaasta - tasu tõusis 300 000krooni : Ülikoolid: rektorite sissetulek kasvab / Kadri Paas

    Index Scriptorium Estoniae

    Paas, Kadri, 1982-

    2010-01-01

    Eesti suuremate kõrgkoolide rektorite sissetulek on aastaid kerkinud, sõltumata sellest, kas majandus õitseb või langeb. Mullust edetabelit juhib Tallinna Tehnikaülikooli rektor Peep Sürje, kelle aastatasu kerkis 300 000 krooni võrra. Ka Tartu Ülikooli rektori Alar Karise ja Tallinna Ülikooli rektori Rein Raua palkadest

  8. Sozialarbeit, Ethik und Moral

    DEFF Research Database (Denmark)

    Zeller, Jörg

    2011-01-01

    Social prækarisering stiller den enkelte socialarbejder for problemer, der kun samfundet som helhed kunne løse. Det medfører, at socialarbejderen som individuel repræsentant af samfundsmoralen er konfronteret med et etisk dilemma....

  9. Vana-aasta filmiõhtu

    Index Scriptorium Estoniae

    2002-01-01

    Kanal2s oli sügisel telesari eesti tuntud arstidest, keda on filmitud aasta vältel. Helle Karise portreefilmide sarja "Contra mortem" näidatakse ka 30. detsembril Kinomajas filmiõhtul. Kohtuda saab ka arstide endiga

  10. Terroristlike rühmituste liikmete sihttapmiste õiguspärasus rahvusvahelises humanitaarõiguses : [magistritöö] / Marika Kütt ; Tartu Ülikool, õigusteaduskond ; juhendaja: Lauri Mälksoo

    Index Scriptorium Estoniae

    Kütt, Marika

    2011-01-01

    Sihttapmistest kui ametlikust vahendist terrorismivastases võitluses, inimõigustest selles kontekstis, relvakonflikti olemasolust kui eeldusest rahvusvahelise humanitaarõiguse kohaldumiseks, sihttapmiste legaalsusest mitterahvusvahelise relvastatud konflikti korral

  11. Pre-Viking and early Viking Age sacrifical place at Viidumäe, west Saaremaa / Marika Mägi, Indrek Jets, Riina Riiel, Raili Allmäe

    Index Scriptorium Estoniae

    2015-01-01

    Viidumäe ohverduskoht on eriti märkimisväärne selle poolest, et kuulub perioodi,millest Saaremaal muistised peaaegu puuduvad. Leiukoht osutab, et Eesti rannikukultuuri skandinaavitumine, mis on jälgitav alates 10. sajandist, sai alguse juba hiljemalt 8. sajandil

  12. Ööpäeva väldanud etendused keerasid näitlejate ja publiku elurütmi pea peale / Marika Rajamäe, Merili Nikkolo

    Index Scriptorium Estoniae

    Rajamäe, Marika, 1952-

    2008-01-01

    Vargamäel 22 tundi kestnud maratonetendusest Tammsaare "Tõe ja õiguse" põhjal - Elmo Nüganeni lavastused "Tõde ja õigus. Teine osa", "Karin. Indrek. Tõde ja õigus. 4" ja "Wargamäe Wabariik" (III osa) ning Jaanus Rohumaa lavastus "Vargamäe kuningriik" (I ja V osa). Reportaaž on tähtsamatest hetkedest alates 21. juuni kell 11.00 kuni 22. juuni 10.00-ni

  13. 21. X avati Kaunase kunstibiennaal "Textile 2005"

    Index Scriptorium Estoniae

    2005-01-01

    Eestist osalevad Mare Kelpmann, Marika Kööbi, Aet Ollisaar, Kadi Pajupuu, Ludmilla Svarzhevska, Hanna Tiidus, Helen Kauksi, Krista Leesi, Aune Taamal, Erika Tammpere, Milvi Thalheim ja Erle Võsa-Tangsoo

  14. Katrin Kuldma - obladatelnitsa "Zolotoi iglõ" / Olga Grigorjeva

    Index Scriptorium Estoniae

    Grigorjeva, Olga, 1983-

    2007-01-01

    FIBIT-i moepäevadest ja Kuldnõela galast. Kuldnõela nominendid olid Reet Aus, Katrin Kuldma, Marika Siska ja Tiiu Roosma. 2006. a. moepreemia "Kuldnõel" sai kollektsiooni "Chocolat" eest Katrin Kuldma

  15. Raamatututvustus

    Index Scriptorium Estoniae

    2008-01-01

    2007. a. Tallinnas kirjastuselt Varrak ilmunud raamatust "1001 maali, mida elu jooksul peab nägema" (peatoimetaja Stephen Farthing, eessõna Geoff Dyer, tõlkinud Ann Kitsnik, Marika Liivamägi ja Maarja Merivoo)

  16. Teaduse õpetamine kui missioon

    Index Scriptorium Estoniae

    2010-01-01

    Marika Mikelsaar pälvis teaduse elutöö preemia, millest osa kavatseb kasutada omanimelise fondi loomiseks noorte teadlaste jaoks. Hiljuti valiti ta ülemaailmse ühingu Society for Microbial Ecology and Disease (SOMED) presidendiks

  17. Kirev moepilt / Britt Rosen

    Index Scriptorium Estoniae

    Rosen, Britt, 1968-

    2007-01-01

    FIBITi moepäevadest Tallinnas Viru keskuses, stilistid Gerli Tinn, Liisi Eesmaa, Kirill Safonov. Kuldnõela auhinna pälvis Katrin Kuldma kollektsiooni Chocolat eest. Oma loomingut esitlesid Reet Aus, Tiiu Roosma, Marika Siska

  18. Trepp = Stair / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2006-01-01

    Rakvere Vallimäe trepist. Laste vestlus trepil. Projekt: Kavakava. Autorid: Heidi Urb, Siiri Vallner. Trepi valem: Taavi Vallner. Insener: Marika Stokkeby. Projekt 2004, valmis 2005. Ill.: joonis, 7 värv. fotot

  19. Tunnustame tõenduspõhise õendusabi edendajaid / Ester Öpik, Ilme Aro

    Index Scriptorium Estoniae

    Öpik, Ester

    2014-01-01

    Tunnustati meditsiiniõdesid Tiina Freimanni, Reet Urbanit, Marika Asbergi, Tiina Tõemetsa, Kersti Viitkarit ja Ireen Bruusi Eesti Õdede Liidu poolt 2011. aastani kaitstud õendusteaduslike uurimistööde eest

  20. The New Forekspank ئ Acclaimed Bank Architecture / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    1998-01-01

    Pangahoonete ehitamisest Eestis: Eesti Pank, Hansapank, Tallinna Pank (praegu Ühispank). Pikemalt Forekspanga (praegune Optivapank) hoone ehitamisest endisesse tehasehoonesse. Arhitektid Jüri Okas ja Marika Lõoke.. Sisekujundus Tõnu Veimer.

  1. Alushariduse kvaliteet rahvusvahelises arutelus / Tiia Õun

    Index Scriptorium Estoniae

    Õun, Tiia

    2013-01-01

    Rahvusvahelisest EECERA 23. konverentsist, mis ühendab Euroopa alushariduse uurijaid, juhte, õpetajaid ja üliõpilasi. Konverents toimus 28.-31. aug. Tallinna Ülikoolis, Eesti-poolne peakorraldaja oli Tallinna Ülikooli professor Marika Veisson

  2. Tallinnasse Rävala pst. 19 kavandatava Tallinna Muusikakeskkooli, Tallinna Balletikooli ning G. Otsa nimelise muusikakooli ühise õppehoone arhitektuurikonkurss = Architectural Competition for the Joint School Building of Tallinn Music-Specialised

    Index Scriptorium Estoniae

    Puusepp, Raivo

    2003-01-01

    I preemia - Andres Siim, Krister Ausing, II - Marika Lõoke, III - Maia Tüür, Andres Sevtshuk, Gabriel Evangelisti, ostupreemiad: Armin Valter, Vilen Künnapu ning Siiri Vallner, Katrin Koov, Veronika Valk

  3. Omamoodi ime - ilmunud on eesti-läti sõnaraamat / Lembit Vaba

    Index Scriptorium Estoniae

    Vaba, Lembit 1945-

    2015-01-01

    Arvustus: Igauņu-latviešu vārdnīca / Latviešu valodas aģentūra ; sastādītāji: Valts Ernštreits, Marika Muzikante, Maima Grīnberga = Eesti-läti sõnaraamat / Läti keele agentuur ; koostajad: Valts Ernštreits, Marika Muzikante, Maima Grīnberga. Rīga ; Tallinn : Eesti Keele Sihtasutus, 2015

  4. The assessment of minor neurological dysfunction in infancy using the Touwen Infant Neurological Examination : strengths and limitations

    NARCIS (Netherlands)

    Hadders-Algra, Mijna; Heineman, Kirsten R.; Bos, Arend F.; Middelburg, Karin J.

    Aim Little is known of minor neurological dysfunction (MND) in infancy. This study aimed to evaluate the inter-assessor reliability of the assessment of MND with the Touwen Infant Neurological Examination (TINE) and the construct and predictive validity of MND in infancy. Method Inter-assessor

  5. WAIS Digit Span-Based Indicators of Malingered Neurocognitive Dysfunction: Classification Accuracy in Traumatic Brain Injury

    Science.gov (United States)

    Heinly, Matthew T.; Greve, Kevin W.; Bianchini, Kevin J.; Love, Jeffrey M.; Brennan, Adrianne

    2005-01-01

    The present study determined specificity and sensitivity to malingered neurocognitive dysfunction (MND) in traumatic brain injury (TBI) for several Wechsler Adult Intelligence Scale (WAIS) Digit Span scores. TBI patients (n = 344) were categorized into one of five groups: no incentive, incentive only, suspect, probable MND, and definite MND.…

  6. MINOR NEUROLOGICAL DYSFUNCTION AFTER THE ONSET OF PUBERTY - ASSOCIATION WITH PERINATAL EVENTS

    NARCIS (Netherlands)

    SOORANILUNSING, RJ; HADDERSALGRA, M; HUISJES, HJ; TOUWEN, BCL

    In order to study the hypotheses that puberty is related to a decrease of minor neurological dysfunction (MND) and that persisting MND is associated with perinatal factors, two groups (174 normal, 172 MND) of the Groningen Perinatal Project were followed from 12 to 14 years. At 14 years almost all

  7. Motor Neurone Disease: Disability Profile and Service Needs in an Australian Cohort

    Science.gov (United States)

    Ng, Louisa; Talman, Paul; Khan, Fary

    2011-01-01

    Motor neurone disease (MND) places considerable burden upon patients and caregivers. This is the first study, which describes the disability profile and healthcare needs for persons with MND (pwMND) in an Australian sample from the perspective of the patients and caregivers to identify current gaps in the knowledge and service provision. A…

  8. A Dutch family with autosomal recessively inherited lower motor neuron predominant motor neuron disease due to optineurin mutations

    NARCIS (Netherlands)

    Beeldman, Emma; van der Kooi, Anneke J.; de Visser, Marianne; van Maarle, Merel C.; van Ruissen, Fred; Baas, Frank

    2015-01-01

    Approximately 10% of motor neuron disease (MND) patients report a familial predisposition for MND. Autosomal recessively inherited MND is less common and is most often caused by mutations in the superoxide dismutase 1 (SOD1) gene. In 2010, autosomal recessively inherited mutations in the optineurin

  9. "Anything that makes life's journey better." Exploring the use of digital technology by people living with motor neurone disease.

    Science.gov (United States)

    Hobson, Esther V; Fazal, Saima; Shaw, Pamela J; McDermott, Christopher J

    2017-08-01

    Our aim was to explore the attitudes of those living with motor neuron disease towards digital technology. Postal and online questionnaires surveyed 83 people with MND (pwMND) and 54 friends and family members (fMND). Five pwMND and five fMND underwent semi-structured interviews. 82% of pwMND and 87% of fMND use technology every day with iPads and laptops being the devices most commonly used. pwMND used technology to help them continue to participate in everyday activities such as socialising, entertainment and accessing the internet. The internet provided peer support and information about MND but information could be distressing or unreliable. Participants preferred information from professionals and official organisations. Participants were generally supportive of using of technology to access medical care. Barriers to technology, such as lack of digital literacy skills and upper limb dysfunction, and potential solutions were identified. More challenging barriers included language and cognitive difficulties, and the fear of becoming dependent on technology. Addressing the barriers identified in this research could help pwMND access technology. However, as healthcare delivery becomes more reliant on digital technology, care should be taken to ensure that those who are unable or unwilling to use technology continue to have their needs met in alternative ways.

  10. Heavy metals in locus ceruleus and motor neurons in motor neuron disease.

    Science.gov (United States)

    Pamphlett, Roger; Kum Jew, Stephen

    2013-12-12

    The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to look for AMG-stainable heavy metals (inorganic mercury and bismuth) in LC and motor neurons of 24 patients with MND (18 with SALS and 6 with familial MND) and in the LC of 24 controls. Heavy metals in neurons were found in significantly more MND patients than in controls when comparing: (1) the presence of any versus no heavy metal-containing LC neurons (MND 88%, controls 42%), (2) the median percentage of heavy metal-containing LC neurons (MND 9.5%, control 0.0%), and (3) numbers of individuals with heavy metal-containing LC neurons in the upper half of the percentage range (MND 75%, controls 25%). In MND patients, 67% of remaining spinal motor neurons contained heavy metals; smaller percentages were found in hypoglossal, nucleus ambiguus and oculomotor neurons, but none in cortical motor neurons. The majority of MND patients had heavy metals in both LC and spinal motor neurons. No glia or other neurons, including neuromelanin-containing neurons of the substantia nigra, contained stainable heavy metals. Uptake of heavy metals by LC and lower motor neurons appears to be fairly common in humans, though heavy metal staining in the LC, most likely due to inorganic mercury, was seen significantly more often in MND patients than in controls. The LC innervates many cell types that are affected in MND, and it is possible that MND is triggered by toxicant-induced interactions between LC and motor neurons.

  11. Heavy metals in locus ceruleus and motor neurons in motor neuron disease

    Science.gov (United States)

    2013-01-01

    Background The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to look for AMG-stainable heavy metals (inorganic mercury and bismuth) in LC and motor neurons of 24 patients with MND (18 with SALS and 6 with familial MND) and in the LC of 24 controls. Results Heavy metals in neurons were found in significantly more MND patients than in controls when comparing: (1) the presence of any versus no heavy metal-containing LC neurons (MND 88%, controls 42%), (2) the median percentage of heavy metal-containing LC neurons (MND 9.5%, control 0.0%), and (3) numbers of individuals with heavy metal-containing LC neurons in the upper half of the percentage range (MND 75%, controls 25%). In MND patients, 67% of remaining spinal motor neurons contained heavy metals; smaller percentages were found in hypoglossal, nucleus ambiguus and oculomotor neurons, but none in cortical motor neurons. The majority of MND patients had heavy metals in both LC and spinal motor neurons. No glia or other neurons, including neuromelanin-containing neurons of the substantia nigra, contained stainable heavy metals. Conclusions Uptake of heavy metals by LC and lower motor neurons appears to be fairly common in humans, though heavy metal staining in the LC, most likely due to inorganic mercury, was seen significantly more often in MND patients than in controls. The LC innervates many cell types that are affected in MND, and it is possible that MND is triggered by toxicant-induced interactions between LC and motor neurons. PMID:24330485

  12. Relationship between 3-Methyl-2,4-nonanedione Concentration and Intensity of Light-induced Off-odor in Soy Bean Oil.

    Science.gov (United States)

    Sano, Takashi; Iwahashi, Maiko; Imagi, Jun; Sato, Toshiro; Yamashita, Toshiyuki; Fukusaki, Eiichiro; Bamba, Takeshi

    2016-05-01

    A beany and green off-odor is developed in soy bean oil (SBO) under light-induced oxidative conditions. 3-Methyl-2,4-nonanedione (3-MND) was inferred as the compound responsible for the off-odor. In this study, we designed a simple quantification method for 3-MND in SBO, and evaluated the relationship between the 3-MND concentration and the intensity of the off-odor. 3-MND was analyzed by GC/MS with a thermal desorption unit system. By our method, the 3-MND concentration was found to increase with storage days and the SBO content under light exposure, and there was a high correlation between the measured 3-MND concentration and the intensity of the light-induced off-odor in SBO (R = 0.9586).

  13. Two Studies on Twitter Networks and Tweet Content in Relation to Amyotrophic Lateral Sclerosis (ALS): Conversation, Information, and 'Diary of a Daily Life'.

    Science.gov (United States)

    Hemsley, Bronwyn; Palmer, Stuart

    2016-01-01

    To date, there is no research examining how adults with Amyotrophic Lateral Sclerosis (ALS) or Motor Neurone Disease (MND) and severe communication disability use Twitter, nor the use of Twitter in relation to ALS/MND beyond its use for fundraising and raising awareness. In this paper we (a) outline a rationale for the use of Twitter as a method of communication and information exchange for adults with ALS/MND, (b) detail multiple qualitative and quantitative methods used to analyse Twitter networks and tweet content in the our studies, and (c) present the results of two studies designed to provide insights on the use of Twitter by an adult with ALS/MND and by #ALS and #MND hashtag communities in Twitter. We will also discuss findings across the studies, implications for health service providers in Twitter, and directions for future Twitter research in relation to ALS/MND.

  14. Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis.

    Science.gov (United States)

    Statland, Jeffrey M; Barohn, Richard J; McVey, April L; Katz, Jonathan S; Dimachkie, Mazen M

    2015-11-01

    When approaching a patient with suspected motor neuron disease (MND), the pattern of weakness on examination helps distinguish MND from other diseases of peripheral nerves, the neuromuscular junction, or muscle. MND is a clinical diagnosis supported by findings on electrodiagnostic testing. MNDs exist on a spectrum, from a pure lower motor neuron to mixed upper and lower motor neuron to a pure upper motor neuron variant. Amyotrophic lateral sclerosis (ALS) is a progressive mixed upper and lower motor neuron disorder, most commonly sporadic, which is invariably fatal. This article describes a pattern approach to identifying MND and clinical features of sporadic ALS. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Nonmotor symptoms in patients suffering from motor neuron diseases

    Directory of Open Access Journals (Sweden)

    Rene Günther

    2016-07-01

    Full Text Available Background: The recently postulated disease spreading hypothesis has gained much attention, especially for Parkinson’s disease (PD. The various nonmotor symptoms (NMS in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND is primarily known as a group of diseases with a selective loss of motor function. Recent evidence, however, suggests disease spreading into nonmotor brain regions also in MND. The aim of this study was to comprehensively detect NMS in patients suffering from MND.Methods: We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric and sleep complaints (NMSQuest which is an established tool in PD patients. 90 MND patients were included and compared to 96 controls.Results: In total, MND patients reported significantly higher NMS scores (median: 7 points in comparison to controls (median: 4 points. Dribbling, impaired taste/smelling, impaired swallowing, weight loss, loss of interest, sad/blues, falling and insomnia were significantly more prevalent in MND patients compared to controls. Interestingly excessive sweating was more reported in the MND group. Correlation analysis revealed an increase of total NMS score with disease progression.Conclusions: NMS in MND patients seemed to increase with disease progression which would fit with the recently postulated disease spreading hypothesis. The total NMS score in the MND group significantly exceeded the score for the control group, but only 8 of the 30 single complaints of the NMSQuest were significantly more often reported by MND patients. Dribbling, impaired swallowing, weight loss and falling could primarily be connected to motor neuron degeneration and declared as motor symptoms in MND.

  16. Non-Motor Symptoms in Patients Suffering from Motor Neuron Diseases.

    Science.gov (United States)

    Günther, René; Richter, Nicole; Sauerbier, Anna; Chaudhuri, Kallol Ray; Martinez-Martin, Pablo; Storch, Alexander; Hermann, Andreas

    2016-01-01

    The recently postulated "disease spreading hypothesis" has gained much attention, especially for Parkinson's disease (PD). The various non-motor symptoms (NMS) in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND) is primarily known as a group of diseases with a selective loss of motor function. However, recent evidence suggests disease spreading into non-motor brain regions also in MND. The aim of this study was to comprehensively detect NMS in patients suffering from MND. We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric, and sleep complaints [NMS questionnaire (NMSQuest)], which is an established tool in PD patients. 90 MND patients were included and compared to 96 controls. In total, MND patients reported significantly higher NMS scores (median: 7 points) in comparison to controls (median: 4 points). Dribbling, impaired taste/smelling, impaired swallowing, weight loss, loss of interest, sad/blues, falling, and insomnia were significantly more prevalent in MND patients compared to controls. Interestingly, excessive sweating was more reported in the MND group. Correlation analysis revealed an increase of total NMS score with disease progression. NMS in MND patients seemed to increase with disease progression, which would fit with the recently postulated "disease spreading hypothesis." The total NMS score in the MND group significantly exceeded the score for the control group, but only 8 of the 30 single complaints of the NMSQuest were significantly more often reported by MND patients. Dribbling, impaired swallowing, weight loss, and falling could primarily be connected to motor neuron degeneration and declared as motor symptoms in MND.

  17. Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.

    Science.gov (United States)

    Takeda, Takahiro; Seilhean, Danielle; Le Ber, Isabelle; Millecamps, Stéphanie; Sazdovitch, Véronique; Kitagawa, Kazuo; Uchihara, Toshiki; Duyckaerts, Charles

    2017-09-01

    TDP-43-positive inclusions are present in the amygdala in frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND) including amyotrophic lateral sclerosis. Behavioral abnormalities, one of the chief symptoms of FTLD, could be, at least partly, related to amygdala pathology. We examined TDP-43 inclusions in the amygdala of patients with sporadic FTLD/MND (sFTLD/MND), FTLD/MND with mutation of the C9ORF72 (FTLD/MND-C9) and FTLD with mutation of the progranulin (FTLD-GRN). TDP-43 inclusions were common in each one of these subtypes, which can otherwise be distinguished on topographical and genetic grounds. Conventional and immunological stainings were performed and we quantified the numerical density of inclusions on a regional basis. TDP-43 inclusions in amygdala could be seen in 10 out of 26 sFTLD/MND cases, 5 out of 9 FTLD/MND-C9 cases, and all 4 FTLD-GRN cases. Their numerical density was lower in FTLD/MND-C9 than in sFTLD/MND and FTLD-GRN. TDP-43 inclusions were more numerous in the ventral region of the basolateral nucleus group in all subtypes. This contrast was apparent in sporadic and C9-mutated FTLD/MND, while it was less evident in FTLD-GRN. Such differences in subregional involvement of amygdala may be related to the region-specific neuronal connections that are differentially affected in FTLD/MND and FTLD-GRN. © 2017 American Association of Neuropathologists, Inc. All rights reserved.

  18. Archaeological excavations at a bronze age grave and a 6th - 10 th century cult site at Aunamägi in Tõnija-Põlluküla village, southern Saaremaa / Marika Mägi, Raili Allmäe, Riina Riiel ... [jt.

    Index Scriptorium Estoniae

    2015-01-01

    Kaevamised Saunamäel korraldati Tallinna Ülikooli üliõpilaste seminarkaevamistena. Kogu kaevamiste ala moodustas umbes 170 m2. Märkimisväärne Tuulingumäe ja Saunamäe kompleksi juures on see, et need olid mõeldud suhteliselt piiratud hulgale. Sellised väikesed pühapaigad viitavad rituaalidele, mida sooritasid üksikud valitud isikud. Kõik artiklis mainitud kultusekohad jäävad Läänemere põhjaosa rannikualadele, kus eelviikingiajal kujunes ühine kultuurisfäär

  19. TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations.

    NARCIS (Netherlands)

    Seelaar, H.; Schelhaas, H.J.; Azmani, A.; Kusters, B.; Rosso, S.; Majoor-Krakauer, D.F.; Rijik, M.C. de; Rizzu, P.; Brummelhuis, M. Ten; Doorn, P.A. van; Kamphorst, W.; Willemsen, R.; Swieten, J. van

    2007-01-01

    Frontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in approximately 10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal

  20. TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations

    NARCIS (Netherlands)

    H. Seelaar (Harro); H. Jurgen Schelhaas; A. Azmani (Asma); B. Küsters (Benno); S.M. Rosso (Sonia); D.F. Majoor-Krakauer (Danielle); M.C. de Rijik (Maarten); P. Rizzu (Patrizia); M. ten Brummelhuis (Ming); P.A. van Doorn (Pieter); W. Kamphorst (Wouter); R. Willemsen (Rob); J.C. van Swieten (John)

    2007-01-01

    textabstractFrontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in ∼10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal

  1. NEUROBEHAVIORAL RELATIONSHIPS AND PUBERTY - ANOTHER TRANSFORMATION

    NARCIS (Netherlands)

    SOORANILUNSING, RJ

    In a follow-up study of the Groningen Perinatal Project (GPP) on minor neurological dysfunction (MND) at 12 and 14 years the onset of puberty appeared to play a role. The children were selected on the presence (n = 185) and absence (n = 185) of MND at 9 years. Puberty was defined by the presence of

  2. Progressive Apraxia of Speech as a Sign of Motor Neuron Disease

    Science.gov (United States)

    Duffy, Joseph R.; Peach, Richard K.; Strand, Edythe A.

    2007-01-01

    Purpose: To document and describe in detail the occurrence of apraxia of speech (AOS) in a group of individuals with a diagnosis of motor neuron disease (MND). Method: Seven individuals with MND and AOS were identified from among 80 patients with a variety of neurodegenerative diseases and AOS (J. R. Duffy, 2006). The history, presenting…

  3. Computational Analysis of Pharyngeal Swallowing Mechanics in Patients with Motor Neuron Disease: A Pilot Investigation.

    Science.gov (United States)

    Garand, K L; Schwertner, Ryan; Chen, Amy; Pearson, William G

    2018-04-01

    Swallowing impairment (dysphagia) is a common sequela in patients with motor neuron disease (MND). The purpose of this retrospective, observational pilot investigation was to characterize how pharyngeal swallowing mechanics are impacted in patients with MND using a comparison with healthy, non-dysphagic control group. Computational analysis of swallowing mechanics (CASM) was used to determine covariate biomechanics of pharyngeal swallowing from videofluoroscopic assessment in 15 patients with MND and 15 age- and sex-matched healthy controls. Canonical variant analysis with post hoc discriminate function analysis (DFA) was performed on coordinate data mapping functional muscle groups underlying pharyngeal swallowing. Differences in swallowing mechanics associated with group (MND; control), motor neuron predominance (upper; lower), onset (bulbar; spinal), and swallow task (thin, pudding) were evaluated and visualized. Pharyngeal swallowing mechanics differed significantly in patients with MND compared with healthy controls (D = 2.01, p mechanics by motor neuron predominance (D = 5.03, p mechanics of patients with MND differ from and are more heterogeneous than healthy controls. These findings suggest patients with MND may compensate reductions in pharyngeal shortening and tongue base retraction by extending the head and neck and increasing hyolaryngeal excursion. This work and further CASM investigations will lead to further insights into development and evaluation of targeted clinical treatments designed to prolong safe and efficient swallowing function in patients with MND.

  4. Innovatsioon = Innovation

    Index Scriptorium Estoniae

    2008-01-01

    TÜ teadlased töötavad välja Philipsi tellimusel uut tomograafi; prof. Marika Mikelsaar pälvis bakteri ME-3 kasutamise eest Euroopa Liidu innovaatori auhinna; toruluude murdude fragmentide ühendamiseks koostatud leiutisele said patendi Aleks Lenzner ja Tiit Haviko TÜ-st ning Vladimir Andrianov EMÜ-st

  5. Mis on elus olulisim / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2002-01-01

    Sisu : Mitch Albom. Teisipäevad Morrie'ga; Santa Montefiore. Oota mind ombupuu all; Ridley Pearson. Tont teab kus; Sebastian Faulks. Linnulaul; Kerttu Rakke. Iluasjake; Merike Hanni. Kooliraha; Viivi Luik. Ajaloo ilu; Hermann Hesse. Stepihunt; Eesti luulet läbi aegade / [koostanud Marika Vingissar; Philip K. Dick. Ubik; Marion Zimmer Bradley. Avaloni udud; Kuus eesti luuletajat / koostanud Anne Lange

  6. Teenetemärgid

    Index Scriptorium Estoniae

    2005-01-01

    Tartu Ülikooli kollektiivi liikmetest saavad Eesti vabariigi 87. aastapäeva puhul riikliku autasu külalisprofessorid Stig Erik örjan Ohlsson ja Uno lõhmus, professorid mati Erelt, Volli kalm, kalle merusk, Aadu Must, Paul varul, Jaan Eha, bibliograaf Marika Meltsas

  7. Ülikool valis viis professorit ja nimetas emeriitprofessori (TPM)

    Index Scriptorium Estoniae

    2004-01-01

    Tartu Ülikooli nõukogu nimetas professoriteks tagasi Eesti ajaloo professori Tiit Rosenbergi, eesti keele kui võõrkeele professori Birute Klaasi, rakendusökoloogia professori Olevi Kulli ja majanduspoliitika professori Jüri Sepa. Balti poliitika professoriks sai Andres Kasekamp. Ülikooli mikrobioloogia instituudi juhatajale professor Marika Mikelsaarele anti emeriitprofessori nimetus

  8. Autotranspordi TOP aastal 2007

    Index Scriptorium Estoniae

    2008-01-01

    TOP 50. Vt. samas: Käibe TOP 10; Käibe kasvu TOP 10; Kasumi TOP 10; Kasumi kasvu TOP 10; Rentaabluse TOP 10; Omakapitali tootlikkuse TOP 10; Marika Roomere. Täisteenuse pakkumine kergitas tulemusi; Jupiter Plus otsib järjest uusi kasvuvõimalusi; EST-Trans Kaubaveod teenib kasumit toiduvedamisega

  9. Kuidas töötab teie kooli tugisüsteem? / Maria Tiro, Siiri Klasberg, Maarika Kongi ... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastasid Jüri gümnaasiumi direktor Maria Tiro, Tapa gümnaasiumi sotsiaalpedagoog Siiri Klasberg, Rakvere gümnaasiumi psühholoog Maarika Kongi, Kuressaare gümnaasiumi sotsiaalpedagoog Maret Martinson, Salme põhikooli direktor Marika Pütsep

  10. Lahkus juhmi Hundi ja kavala Jänese looja / Andri Maimets, Marko Lillemägi

    Index Scriptorium Estoniae

    Maimets, Andri, 1979-

    2006-01-01

    Suri vene animakunstnik, kuulsate tegelaskujude - Hundi ja Jänese looja joonisfilmisarjas (1969-1986) "Oota sa!" ("Nu, pogodi!") Svetozar Russakov (sünd. 3.04.1923). Filmi omaaegset mõju meenutab Rein Raamat. Kommenteerivad Raivo Järvi, Hendrik Normann, Ain Nurmela, Marika Korolev, Evelin Samuel

  11. Estconde büroohoone = Estconde Office Building / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2002-01-01

    Tallinnas Toompuiestee 33 asuva hoone rekonstrueerimine. Projekteerija: büroo J. Okas & M. Lõoke. Arhitektid Jüri Okas ja Marika Lõoke. Konstruktiivne osa: Neoprojekt. Ehituse peatöövõtt: Estconde-E. Projekt ja hoone valmisid 2001. 7 ill.: välis- ja sisevaated, II korruse plaan

  12. Poolsajandi õnnesoovid Jaak Aaviksoole / Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar...[jt.

    Index Scriptorium Estoniae

    2004-01-01

    Mõtteid Tartu Ülikooli rektorist tema 50. sünnipäeva puhul : Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar, Indrek Reimand, Toomas Kiho, Leelo Kriisa, Peeter Olesk, Risto Tammelo, Birute Klaas, Peeter Saari, Andrus Ansip, Mait Klaassen, Marika Kullamaa, Kaupo Bend

  13. 8. III esitleti Adamson-Ericu muuseumis ajakirja Muuseum 2005. aasta esimest numbrit

    Index Scriptorium Estoniae

    2005-01-01

    Tomislav Shola kirjutab "Kvaliteedist pärimusinstitutsioonides". Rahvusvaheliste konverentside kogemusi jagavad Toomas Abiline, Aino Lepp, Lea Sillart ja Karin Hallas-Murula. Eesti muuseumide olulistest tähtpäevadest kirjutavad Urmas Dresen, Mari-Ann Aimla, Marika Valk ja Merike Koppel

  14. Vanemuise teatri juurdeehituse kutsutud arhitektuurikonkurss = Invitational architecture competition for the addition to the Vanemuine theatre / Peeter Pere

    Index Scriptorium Estoniae

    Pere, Peeter, 1957-

    2009-01-01

    Arhitektuurikonkursi žürii liige Peeter Pere võistluse eesmärgist, konkursil 1. preemia pälvinud Jüri Okase ja Marika Lõokese (Okas & Lõoke) võistlustööst ja konkursil osalenud arhitektuuribüroode Kolm Pluss Üks, Kavakava ja Lunge & Ko võistlustöödest

  15. Arhitektuuribüroo Pluss = Pluss Architects

    Index Scriptorium Estoniae

    2009-01-01

    Büroohoones Delta Plaza (Pärnu mnt. 141, Tallinn) asuva AB Pluss ruumide sisekujundusest. Sisearhitektid Argo Vaikla, Katrin Vaikla ja Riin Luuk. Büroohoone arhitektid Jüri Okas ja Marika Lõoke. Kogu mööblikomplekt on erilahendusega. Sisearhitektide tähtsamate tööde loetelu

  16. Scheteligi büroo- ja laohoone = Schetelig's Office Building and Warehouse / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2000-01-01

    Kahekorruseline, minimalistliku kastja mahuga hoone. Peafassaadi kujunduses on kasutatud firma nime. Projekteerija Arhitektibüroo J. Okas & M. Lõoke. Arhitektid Jüri Okas, Marika Lõoke. Sisekujundaja Kristiina Voolaid. Projekt 1998, valmis 2000. 7 ill. Korruste plaanid, lõige, välisvaated

  17. Projektiivne arhitektuur / Leonhard Lapin

    Index Scriptorium Estoniae

    Lapin, Leonhard, 1947-

    2003-01-01

    Arhitekti loomeprotsess. Arhitekti ja helilooja loomemeetodi sarnasus. Omaruumi mõiste. Projektiivne arhitektuur. Jüri Okase ja Marika Lõokese projektiivne arhitektuur, nende 1996-2002. aastate 22 projekti 40 perspektiivvaadet esikaanel, lk. 1, 11-48. J. Okasele ja M. Lõokesele anti 2002. a. arhitektuuriloomingu eest Eesti Kultuurkapitali aastapreemia

  18. Eurohindu tuleb näidata enne kursi selgumist / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2010-01-01

    1. juulist tuleb avaldada kaupade ja teenuste hinnad nii kroonides kui ka eurodes. Arvamust avaldavad Eesti Kaupmeeste Liidu tegevdirektor Marika Merilai, ASi Rimi Eesti Food turundusjuht Evelin Mägioja ja OÜ Maxima Eesti brändi ja kommunikatsiooni osakonna direktor Ty Lehtmäe

  19. Salme Reegi nimelise auhinna nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Valiti järgmised nominendid : Taago Tubin - lavastus "Suur kuri hunt" Vanemuises, Marika Vaarik - õpetaja Klamm VAT Teatri lavastuses "Klammi sõda", Finn Poulsen - "Trollpoiss" Eesti Nukuteatris, Leino Rei - lavastused "Kuusepuu", "Karjatüdruk ja korstnapühkija", Taavi Tõnisson - Papageno "Võluflöödis" Eesti Nukuteatri lavastuses

  20. Kuldma, Aus, Roosma ja Siska

    Index Scriptorium Estoniae

    2007-01-01

    2006. aasta Kuldnõela võitja kuulutatakse välja Tallinnas Viru keskuses 9.03.2007. Kandidaadid Katrin Kuldma kollektsiooniga Chocolate, Reet Aus kaubamärgiga Re Use, Tiiu Roosma pesukollektsiooniga BonBon Lingerie ja Marika Siska kaubamärgiga Sangar

  1. Riik reklaamib Tallinna napsi ja naistega / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2005-01-01

    Ettevõtluse Arendamise Sihtasutuse makstud reklaamikampaania, mis valmis reklaamifirmas Brilliant Marketing Communication OÜ, kutsus turismiarendajates esile meelepaha. EAS Turismiarenduskeskuse direktori Marika Liivamäe hinnangul olid mõned kaadrid liiga julged ja ekstreemsed. Reklaamikampaania oli mõeldud Eesti tutvustamiseks Põhjamaa noortele

  2. Eesti Energia : investeerimata oleme varsti hädas / Krista Taim, Allar Viivik

    Index Scriptorium Estoniae

    Taim, Krista

    2004-01-01

    Eesti Energia nõukogu kinnitas ettevõtte investeeringutekava aastani 2018, 15 aasta jooksul tuleb investeerida 46 miljardit krooni, rahastamisallikatena nähakse välislaenu, riigi abi või hinnatõusu. Kommenteerivad Eiki Nestor ja Marika Tuus

  3. Valmib valus lavalugu perest : Athenas jõuab vaatajate ette Mart Kivastiku suhtedraama / Raimu Hanson

    Index Scriptorium Estoniae

    Hanson, Raimu, 1957-

    2008-01-01

    SA Eesti Teatri Festival esietendab 4. mail Athena keskuses Margus Kasterpalu lavastuses Mart Kivastiku näidendit "Meie isa, kes sa oled ..." Mängivad Vanemuise näitlejad Marika Aidla, Hannes Kaljujärv, Tanel Jonas ning Leino Rei

  4. Delta Plaza kohvik = The Delta Plaza Café / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Tallinnas Pärnu mnt. 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Hoone arhitektid Jüri Okas ja Marika Lõoke (AB J. Okas & M. Lõoke). Žürii liikme Mait Summataveti arvamus kohvikust

  5. Delta Plaza kohvik = Delta Plaza cafe

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Pärnu mnt 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Tiiu Truusi tähtsamate tööde loetelu. Büroohoone Delta Plaza arhitektid Marika Lõoke ja Jüri Okas (AB J. Okas & M. Lõoke)

  6. Häbi, professor, teil on Gefilus kapis / Eve Kruuse

    Index Scriptorium Estoniae

    Kruuse, Eve,d1959-

    2008-01-01

    Tartu Ülikooli professor Marika Mikelsaar võitis läinud kuul koos kolleegidega (Tiiu Kullisaar, Epp Songisepp, Hedi Annuk ja Mihkel Zilmer) Soulis ülemaailmse naisleiutajate konkursil ME-3 bakteri avastamise ja probiootikuks arendamise eest kuldmedali

  7. Naisleiutajad said suure tunnustuse

    Index Scriptorium Estoniae

    2008-01-01

    Ehtekunstnik Kärt Summatavet pälvis Soulis toimunud ülemaailmsel naisleiutajate konkursil hõbemedali metallehete valmistamise uudse meetodi eest. Marika Mikelsaar koos töörühmaga Lactobacillus fermentum ME-3 bakterit sisaldava piimatoodete sarja väljatöötamise eest

  8. Juustutööstur Muraka südamevalu / Heidit Kaio

    Index Scriptorium Estoniae

    Kaio, Heidit, 1971-

    2011-01-01

    Euroopa Toiduohutusamet (EFSA) ei tunnustanud Südamejuustu vererõhku langetavat toimet. Nii Südamejuustu tootva E-Piima juht Margus Murakas kui ka teadlane Marika Mikelsaar on otsusest nördinud. M. Mikelsaar räägib Tensia bakteri uuringutest. EFSA pole tunnustanud 99% talle esitatud väidetest mõne toiduaine kasulikkuse kohta

  9. Mamma Bakteri musketärid / Kati Murutar

    Index Scriptorium Estoniae

    Murutar, Kati, 1967-

    2006-01-01

    Tartu Ülikooli teadlase, 2004. Aasta Naiseks nimetatud meditsiinilise biotehnoloogia erakorralise professorr Marika Mikelsaare juhitav töörühm avastas ja tõi maailmakaardile probiootilise piimhappebaketri Lactobacillus fermentum ME-3, mis toimib tervistavalt, hävitades kahjulikke mikroobe

  10. Aesthetics of amalgamation / Francisco Martinez

    Index Scriptorium Estoniae

    Martínez, Francisco, 1982-

    2016-01-01

    Parandamise esteetika kontseptsioonist näituste „Ehitamata. Visioonid uuest ühiskonnast 1986–1994“ Eesti Arhitektuurimuuseumis (kuraator Ingrid Ruudi) ja “Parandamise esteetika tänapäeva Gruusias” (kuraator Marika Agu) Tartu Kunstimuuseum valgusel

  11. Hiigelämblik kanali kohal ehk Kuidas ERMi uus hoone lõi kired lõkkele / Tarmo Michelson

    Index Scriptorium Estoniae

    Michelson, Tarmo, 1975-

    2006-01-01

    Eesti Rahva muuseumi uue hoone arhitektuurikonkursi võidutööst "Memory Field" (autorid itaalia arhitekt Dan Dorell, liibanoni arhitekt Lina Ghotmeh, jaapani arhitekt Tsuyoshi Tane). Kommenteerivad Jaanus Plaat, Tõnis Lukas, Karin Hallas-Murula, Raivo Palmaru, Laine Jänes, Marika Valk

  12. Männikusse kasvatatud Rannametsa / Risto Kozer

    Index Scriptorium Estoniae

    Kozer, Risto

    2009-01-01

    Rannametsa elamukompleks (2 kortermaja, 4 ridaelamut, 3 eramut) Vääna-Jõesuus endise pioneerilaagri "Energia" alal. Arhitektid: Jüri Okas, Marika Lõoke, AB J. Okas & M. Lõoke. Ehitaja: AS YIT Ehitus. Projekt: 2005, valmis: 2007. Kompleks on valatud betoonist, mille juures on kasutatud puitlaudiseid ja alumiiniumviimistlust

  13. Turistid-sõjaõhutajad : dessant Iisraeli / Karin Hallas

    Index Scriptorium Estoniae

    Hallas, Karin, 1957-

    1999-01-01

    Kultuuridessandist Marika Valgu ja Helle Puusepaga Iisraeli. Jeruusalemma Yad Vashemist ئ Holocausti muuseumist. Arhitekt Moshe Safdie Laste Memoriaali ja Yad Vashemi memoriaali uue hoone lahendusest. Tel Avivi ja Jeruusalemma arhitektuurist ئ funktsionalismist, praegusest arhitektuurist, arhitekte. James Turrelli kunstiteosest "Ruum, mis näeb" Jeruusalemma muuseumi pargis

  14. Räägi nii, et pisarad voolaksid! Kuidas saab inimesi oma lugude abil juhtida / Taivo Paju

    Index Scriptorium Estoniae

    Paju, Taivo, 1968-

    2011-01-01

    Kuulajat puudutavate lugude rääkimine. Kuidas toimub lugude loomine inimese ajus. Termin "corporate storytelling". Noppeid Pärnu turunduskonverentsi firmalugude võisturääkimiselt, kus jutustasid Ants Lusti, Marika Pärn, Piret Järvan ja Matts Heijbel

  15. Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging

    Science.gov (United States)

    Yong, Ken-Tye

    2009-01-01

    This work presents a novel approach to producing manganese (Mn)-doped quantum dots (Mnd-QDs) emitting in the near-infrared (NIR). Surface functionalization of Mnd-QDs with lysine makes them stably disperse in aqueous media and able to conjugate with targeting molecules. The nanoparticles were structurally and compositionally characterized and maintained a high photoluminescence quantum yield and displayed paramagnetism in water. The receptor-mediated delivery of bioconjugated Mnd-QDs into pancreatic cancer cells was demonstrated using the confocal microscopy technique. Cytotoxicity of Mnd-QDs on live cells has been evaluated. The NIR-emitting characteristic of the QDs has been exploited to acquire whole animal body imaging with high contrast signals. In addition, histological and blood analysis of mice have revealed that no long-term toxic effects arise from MnD-QDs. These studies suggest multimodal Mnd-QDs have the potentials as probes for early pancreatic cancer imaging and detection.

  16. Trends in motor neuron disease: association with latitude and air lead levels in Spain.

    Science.gov (United States)

    Santurtún, Ana; Villar, Alejandro; Delgado-Alvarado, Manuel; Riancho, Javier

    2016-08-01

    Motor neuron diseases (MND) are a group of disorders characterized by motor neuron degeneration. Among them, amyotrophic lateral sclerosis (ALS) is by far the most common in adulthood. This paper assesses the trend and geographical pattern in MND incidence in Spain and the possible air lead levels effect on this pathology. To confirm this concept, we performed a retrospective analysis of the deaths due to MND in Spain during 2000 and 2013, determined the geographical differences, and explored the relationship between MND and the air levels of lead. Overall, between 2000 and 2013, 11,355 people died in Spain because of MND. Disease mortality significantly increased in recent years (2007-2013) when compared with the first time of the period. Spearman's rank correlation coefficient also showed a statistically significant positive trend (CC = 0.824, p = 0.0002). Among people over 65 years, mortality rates were higher in Northern provinces. Moreover, we found a significant association of MND mortality with higher air lead levels (CC = 0.457, p = 0.01). Our study confirms that MND mortality is increasing in Spain, with a significant latitude gradient, which suggests an important role of environmental exposures. This ecological study suggests that air lead levels may be implicated in ALS pathogenesis.

  17. Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds

    Directory of Open Access Journals (Sweden)

    Baron AV

    2010-01-01

    Full Text Available Abstract Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B1 (AfB1 alone and together with modified nanodiamonds (MND synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and somewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB1 alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB1 with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB1 or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB1 with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR was revealed in liver specimens of the rats that had received AfB1. Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB1 has adsorbed on MND.

  18. Communications Technology and Motor Neuron Disease: An Australian Survey of People With Motor Neuron Disease.

    Science.gov (United States)

    Mackenzie, Lynette; Bhuta, Prarthna; Rusten, Kim; Devine, Janet; Love, Anna; Waterson, Penny

    2016-01-25

    People with Motor Neuron Disease (MND), of which amyotrophic lateral sclerosis (ALS) is the most common form in adults, typically experience difficulties with communication and disabilities associated with movement. Assistive technology is essential to facilitate everyday activities, promote social support and enhance quality of life. This study aimed to explore the types of mainstream and commonly available communication technology used by people with MND including software and hardware, to identify the levels of confidence and skill that people with MND reported in using technology, to determine perceived barriers to the use of technology for communication, and to investigate the willingness of people with MND to adopt alternative modes of communication. An on-line survey was distributed to members of the New South Wales Motor Neuron Disease Association (MND NSW). Descriptive techniques were used to summarize frequencies of responses and cross tabulate data. Free-text responses to survey items and verbal comments from participants who chose to undertake the survey by telephone were analyzed using thematic analysis. Responses from 79 MND NSW members indicated that 15-21% had difficulty with speaking, writing and/or using a keyboard. Commonly used devices were desktop computers, laptops, tablets and mobile phones. Most participants (84%) were connected to the Internet and used it for email (91%), to find out more about MND (59%), to follow the news (50%) or for on-line shopping (46%). A third of respondents used Skype or its equivalent, but few used this to interact with health professionals. People with MND need greater awareness of technology options to access the most appropriate solutions. The timing for people with MND to make decisions about technology is critical. Health professionals need skills and knowledge about the application of technology to be able to work with people with MND to select the best communication technology options as early as possible

  19. Pain in Neurodegenerative Disease : Current Knowledge and Future Perspectives

    NARCIS (Netherlands)

    de Tommaso, Marina; Arendt-Nielsen, Lars; Defrin, Ruth; Kunz, Miriam; Pickering, Gisele; Valeriani, Massimiliano

    2016-01-01

    Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD),

  20. Minor neurological dysfunction and cognition in 9-year-olds born at term

    NARCIS (Netherlands)

    Kikkert, Hedwig K; de Jong, Corina; Hadders-Algra, Mijna

    BACKGROUND: In children with developmental disorders, motor problems often co-occur with cognitive difficulties. Associations between specific cognitive deficits underlying learning problems and minor neurological dysfunction (MND) are still unknown. AIMS: To assess associations between specific

  1. My NASA Data

    Data.gov (United States)

    National Aeronautics and Space Administration — MY NASA DATA (MND) is a tool that allows anyone to make use of satellite data that was previously unavailable.Through the use of MND’s Live Access Server (LAS) a...

  2. The current perception threshold test differentiates categories of mechanical neck disorder.

    Science.gov (United States)

    Uddin, Zakir; MacDermid, Joy C; Galea, Victoria; Gross, Anita R; Pierrynowski, Michael R

    2014-07-01

    Cross-sectional discriminative analysis. To determine whether current perception threshold (CPT) can differentiate between categories of patients with mechanical neck disorders (MNDs). Neck pain is the third most common musculoskeletal disorder and affects a third of all adults each year. It can present as neck pain without musculoskeletal signs, neck pain with musculoskeletal signs but no neurological signs, or neck pain with neurological signs. CPT testing can assess altered sensory perception that may reflect neurological changes. Patients with MNDs (n = 106) were classified into 3 groups, based on a standardized musculoskeletal examination process performed by an experienced physiotherapist who was blinded to CPT scores. The 3 groups were defined as neck pain without musculoskeletal signs (MND I) (n = 60), neck pain with musculoskeletal signs (MND II) (n = 29), and neck pain with neurological signs (MND III) (n = 17). A rapid protocol of CPT testing was performed at 3 frequencies (5, 250, and 2000 Hz), using 3 dermatomal locations on the hand. A 1-way analysis of variance with post hoc comparison and effect sizes was calculated to compare the mean CPT scores between the groups. A binary logistic-regression model was used to predict probability of higher CPT in MND III and to create a receiver-operating-characteristic curve. Mean CPT differed significantly across the 3 MND groups (MND I, 9.7; MND II, 10.6; and MND III, 11.8; Pabnormal CPT in MND III had an estimated 73% sensitivity and 81% specificity; the odds ratio was 11.5 (P = .001) for the differentiation capacity of CPT between MND II and III, with a cutoff of 11. The area under the receiver-operating-characteristic curve was 0.84 (95% confidence interval: 0.72, 0.96; P<.001). CPT testing has moderate discriminatory accuracy, specificity, and sensitivity for classification of MND categories into neck pain with or without neurological signs. J Orthop Sports Phys Ther 2014;44(7):532-540. Epub 10 May 2014

  3. Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis.

    Science.gov (United States)

    Muratori, Paolo; Granito, Alessandro; Ferri, Silvia; Pappas, Georgios; Volta, Umberto; Menichella, Rita; Bianchi, Francesco B; Lenzi, Marco; Muratori, Luigi

    2009-03-01

    Anti nuclear (ANA) immunomorphological patterns such as multiple nuclear dots (MND) and rim-like/membranous (RL/M) are considered highly specific but little sensitive for primary biliary cirrhosis (PBC) diagnosis. To evaluate frequency and clinical significance of MND and RL/M in PBC patients when investigated at the level of immunoglobulin G isotypes. MND and RL/M pattern have been tested in 141 PBC sera and 230 pathological controls using HEp-2 cells as substrate and anti- total IgG and individual IgG subclasses (IgG1, IgG2, IgG3, IgG4) as specific antisera. One hundred and fourteen of 141 (80%) PBC patients had RL/M or MND pattern when IgG subclasses were used as revealing reagents (vs. 34% when anti total IgG were used, p < 0.0001). The prevalent isotype was IgG1 for RL/M, and IgG2 for MND pattern. None of controls was positive. No clinical differences in terms of severity and outcome of disease have been observed in PBC patients positive for MND and RL/M when investigated with IgG isotypes. The research for RL/M and MND pattern at level of IgG isotype determines a wide gain in terms of sensitivity without a loss of specificity. In Italian PBC patients MND and RL/M pattern did not seem to characterize any subgroup of patients with a poorer prognosis.

  4. Feasibility, acceptability, and potential effectiveness of dignity therapy for people with motor neurone disease.

    Directory of Open Access Journals (Sweden)

    Brenda Bentley

    Full Text Available BACKGROUND: Motor neurone disease (MND practice guidelines suggest developing interventions that will promote hope, meaning, and dignity to alleviate psychological distress, but very little research has been done. This study begins to address this need by exploring the use of dignity therapy with people with MND. Dignity therapy is a brief psychotherapy that promotes hope, meaning and dignity, and enhances the end of life for people with advanced cancer. The aims of this study are to assess the feasibility, acceptability, and potential effectiveness of dignity therapy for people with MND. METHODS/DESIGN: This cross-sectional feasibility study used a one-group pre-test post-test design with 29 people diagnosed with MND. Study participants completed the following self-report questionnaires: Herth Hope Index, FACIT-sp, Patient Dignity Inventory, ALS Assessment Questionnaire, ALS Cognitive Behavioural Screen, and a demographic and health history questionnaire. Acceptability was measured with a 25-item feedback questionnaire. Feasibility was assessed by examining the length of time taken to complete dignity therapy and how symptoms common in MND affected the intervention. Generalised linear mixed models and reliable change scores were used to analyse the data. RESULTS: There were no significant pre-test post-test changes for hopefulness, spirituality or dignity on the group level, but there were changes in hopefulness on the individual level. The results of the feedback questionnaire indicates dignity therapy is highly acceptable to people with MND, who report benefits similar to those in the international randomised controlled trial on dignity therapy, a population who primarily had end-stage cancer. Benefits include better family relationships, improved sense of self and greater acceptance. Dignity therapy with people with MND is feasible if the therapist can overcome time and communication difficulties. CONCLUSIONS: Dignity therapy for people with

  5. Racial differences in motor neuron disease.

    Science.gov (United States)

    Gundogdu, Betul; Al-Lahham, Tawfiq; Kadlubar, Fred; Spencer, Horace; Rudnicki, Stacy A

    2014-03-01

    Our objective was to compare and contrast clinical features of black and white patients seen in the UAMS ALS/Motor Neuron Disease (MND) clinic from January 2001 to December 2010. Death certificate information was reviewed to determine race of Arkansans who died of ALS/MND between 1999 and 2006. We used a retrospective chart review of patients with ALS/MND seen at least once in our clinic and reviewed state death certificate data. Results showed that from 1999 to 2006, 466 Arkansas deaths were attributed (immediate or contributory) to ALS/MND; 17 (3.6%) were black, four (0.9%) other, and 445 (95.5%) white. During this period, the proportion of black Arkansans was 17%. From 2001 to 2010, we saw 330 patients with ALS/MND: 30 (9.1%) black, six (1.8%) other, 294 (89.1%) white. Average onset age for whites was 58.1 + 12.4 years, for blacks 52.8 + 13.0 (p = 0.038). Gender, onset site, time from symptom onset to first clinic visit and initial vital capacity were similar between the groups. Initial ALSFRS-R was 37.5 + 7.2 for whites and 30.8 + 8.5 (p = 0.004) for blacks. A first or second degree relative with ALS/MND was reported by 8.1% of whites and by none of the black patients (p = 0.15). Riluzole, PEG and non-invasive ventilation use was similar between the groups. Median tracheostomy-free survival was 36 months for white and 40 months for black patients (p = 0.475). In conclusion, although blacks appear relatively spared from ALS/MND, they present at an earlier age and are functionally worse at their first visit. Investigating the genetic make-up of blacks with the disease may help identify genes that modify risk of developing ALS/MND.

  6. Tubin: The Parson of Reigi / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1993-01-01

    Uuest heliplaadist "Tubin: The Parson of Reigi. Teo Maiste, Marika Eensalu, Ivo Kuusk, Annika Tõnuri, Urve Tauts, Leili Tammel, Tiit Tralla, Arvo Laid. Estonia Opera Company / Paul Mägi; Requiem for Fallen Soldiers. Urve Tauts, Talevaldis Deksnis, Urmas Leiten, Rein Tiido, Rein Roos. Estonian National Male Choir / Eri Klas. Ondine CD ODE 783-2 (2 discs: 116 min.). Recorded in association with the Estonian Cultural Foundation. Requiem - comparative version: Lund. Choral Soc., Järvi (9/88) CD 297

  7. 19.-25. IX toimub Rüütelkonna hoones Kumu pärlite nädal...

    Index Scriptorium Estoniae

    2005-01-01

    23. IX kõneleb Anu Allikvee teemal "Eestlane baltisaksa kunstnike vaatepiiris"; 24. IX tutvustab Mai Levin Eugen Dückeri maale, 25. IX Ene Lamp Konrad Mäge. Vt. ka lk. 24 Tähtede nädal 26. IX-2. X - kohtumisõhtutel esinevad Marika ja Heinz Valk, Jüri Kuuskemaa, Sirje Helme, Pekka Vapaavuori, Inge Teder, Rain Lõhmus

  8. "Habitarel" valitses kerge minimalism

    Index Scriptorium Estoniae

    2003-01-01

    17. mööbli- ja sisustusmess "Habitare" Helsingi Messikeskuses. Noorte sisekujundajate projektikonkursil "TILA+" parim Soome Kunstikõrgkooli õpilaste Marika Aro ja Nana Turuneni töö "Tulemüür". Eesti tootjate esindatus (TVMK kasevineerist tooli ja lauad, Toom Tekstiili villatekid ja padjad). Muljeid disainiüliõpilaselt Anni Kalmuselt, sisearhitekt Aili Aasojalt, TVMK reklaamijuhilt Viivi Rooselt. 4 ill

  9. Pansionaat Pärnus : Seedri 4 = Pension in Pärnu : Seedri 4 / Liina Jänes

    Index Scriptorium Estoniae

    Jänes, Liina, 1977-

    2008-01-01

    Arhitekt Kalle Vellevoog, kaasa töötas Margus Tamm. Sisearhitekt Tiiu Truus. Maastikuarhitekt Vaike Parker. Konstruktor Ahti Lääne. Peatöövõtja: YIT Ehitus AS. Eesti Kultuurkapitali arhitektuuri sihtkapitali 2007. a. arhitektuuripreemia. Žürii liikme Marika Lõokese arvamus. Asendi- ja II korruse plaan, lõige, 3 värv. välisvaadet, sisevaade

  10. Mida ootab lapsevanem? / Raivo Juurak

    Index Scriptorium Estoniae

    Juurak, Raivo, 1949-

    2009-01-01

    Eesti koostöö kogu programmijuht Mati Salundi ja Tallinna Ülikooli sotsiaaltöö instituudi dotsent Anne Tiko viisid möödunud kevadel läbi uuringu, kus selgitasid, mida ootavad 1. klassi astuvate laste vanemad lasteaialt, koolilt, õpetajalt, kohalikult omavalitsuselt. Uuringu tulemusi kommenteerisid vestlusringis Mati Salundi, Lastevanemate Liidu koolitusjuht Kristiine Vahtramäe ja uuringu retsensent, Tallinna Ülikooli kasvatusteaduse instituudi professor Marika Veisson

  11. Äripäev maakonnas : Pärnumaa / Jaana Pikalev

    Index Scriptorium Estoniae

    Pikalev, Jaana

    2007-01-01

    Pärnumaa edukamad firmad 2006. aastal. Vt. samas: Puuduvad töökäed tulevad kutsehariduskeskusest. Kommenteerivad Veljo Truudel, Marika Tettermann ja Tarmo Vanamõisa; Müügitulu headest kaubamärkidest; Menukuses kajastub emafirma edu; 2005. aasta edetabel; Tugeva meeskonnaga töörindel; Pärnumaa Gaselli TOPi juhib kinnisvarafirma. Küsimustele vastab Puls Brewery AS-i juht Aivo Varem

  12. The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design.

    Science.gov (United States)

    Hobson, Esther V; Baird, Wendy O; Partridge, Rebecca; Cooper, Cindy L; Mawson, Susan; Quinn, Ann; Shaw, Pamela J; Walsh, Theresa; Wolstenholme, Daniel; Mcdermott, Christopher J

    2018-08-01

    Attendance at a specialist multidisciplinary motor neurone disease (MND) clinic is associated with improved survival and may also improve quality of life and reduce hospital admissions. However, patients struggle to travel to clinic and may experience difficulties between clinic visits that may not be addressed in a timely manner. We wanted to explore how we could improve access to specialist MND care. We adopted an iterative, user-centered co-design approach, collaborating with those with experience of providing and receiving MND care including patients, carers, clinicians, and technology developers. We explored the unmet needs of those living with MND, how they might be met through service redesign and through the use of digital technologies. We developed a new digital solution and performed initial testing with potential users including clinicians, patients, and carers. We used these findings to develop a telehealth system (TiM) using an Android app into which patients and carers answer a series of questions about their condition on a weekly basis. The questions aim to capture all the physical, emotional, and social difficulties associated with MND. This information is immediately uploaded to the internet for review by the MND team. The data undergoes analysis in order to alert clinicians to any changes in a patient or carer's condition. We describe the benefits of developing a novel digitally enabled service underpinned by participatory design. Future trials must evaluate the feasibility and acceptability of the TiM system within a clinical environment.

  13. Cerebrospinal fluid neurofilament light concentration in motor neuron disease and frontotemporal dementia predicts survival.

    Science.gov (United States)

    Skillbäck, Tobias; Mattsson, Niklas; Blennow, Kaj; Zetterberg, Henrik

    2017-08-01

    To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls. Biomarker concentrations were analysed in relation to recorded cause of death and time of death. MND patients had significantly higher CSF NFL concentrations than FTD patients. Both groups had significantly higher concentrations than the healthy controls (mean 709% increase in MND and 307% increase in FTD). Higher concentrations of CSF NFL were associated with shorter survival in both MND and FTD. The results of this study strengthen the notion of CSF NFL as a useful tool for determining disease intensity in MND and FTD patients. Further studies in patient cohorts with clinically subtyped and genetically classified diagnoses are needed.

  14. Myonuclear domain size and myosin isoform expression in muscle fibres from mammals representing a 100,000-fold difference in body size.

    Science.gov (United States)

    Liu, Jing-Xia; Höglund, Anna-Stina; Karlsson, Patrick; Lindblad, Joakim; Qaisar, Rizwan; Aare, Sudhakar; Bengtsson, Ewert; Larsson, Lars

    2009-01-01

    This comparative study of myonuclear domain (MND) size in mammalian species representing a 100,000-fold difference in body mass, ranging from 25 g to 2500 kg, was undertaken to improve our understanding of myonuclear organization in skeletal muscle fibres. Myonuclear domain size was calculated from three-dimensional reconstructions in a total of 235 single muscle fibre segments at a fixed sarcomere length. Irrespective of species, the largest MND size was observed in muscle fibres expressing fast myosin heavy chain (MyHC) isoforms, but in the two smallest mammalian species studied (mouse and rat), MND size was not larger in the fast-twitch fibres expressing the IIA MyHC isofom than in the slow-twitch type I fibres. In the larger mammals, the type I fibres always had the smallest average MND size, but contrary to mouse and rat muscles, type IIA fibres had lower mitochondrial enzyme activities than type I fibres. Myonuclear domain size was highly dependent on body mass in the two muscle fibre types expressed in all species, i.e. types I and IIA. Myonuclear domain size increased in muscle fibres expressing both the beta/slow (type I; r = 0.84, P fast IIA MyHC isoform (r = 0.90; P muscle fibre type, independent of species. However, myosin isoform expression is not the sole protein determining MND size, and other protein systems, such as mitochondrial proteins, may be equally or more important determinants of MND size.

  15. Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.

    Science.gov (United States)

    Black, Holly A; Leighton, Danielle J; Cleary, Elaine M; Rose, Elaine; Stephenson, Laura; Colville, Shuna; Ross, David; Warner, Jon; Porteous, Mary; Gorrie, George H; Swingler, Robert; Goldstein, David; Harms, Matthew B; Connick, Peter; Pal, Suvankar; Aitman, Timothy J; Chandran, Siddharthan

    2017-03-01

    Genetic understanding of motor neuron disease (MND) has evolved greatly in the past 10 years, including the recent identification of association between MND and variants in TBK1 and NEK1. Our aim was to determine the frequency of pathogenic variants in known MND genes and to assess whether variants in TBK1 and NEK1 contribute to the burden of MND in the Scottish population. SOD1, TARDBP, OPTN, TBK1, and NEK1 were sequenced in 441 cases and 400 controls. In addition to 44 cases known to carry a C9orf72 hexanucleotide repeat expansion, we identified 31 cases and 2 controls that carried a loss-of-function or pathogenic variant. Loss-of-function variants were found in TBK1 in 3 cases and no controls and, separately, in NEK1 in 3 cases and no controls. This study provides an accurate description of the genetic epidemiology of MND in Scotland and provides support for the contribution of both TBK1 and NEK1 to MND susceptibility in the Scottish population. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  16. A Temporal Association between Accumulated Petrol (Gasoline Lead Emissions and Motor Neuron Disease in Australia

    Directory of Open Access Journals (Sweden)

    Mark A. S. Laidlaw

    2015-12-01

    Full Text Available Background: The age standardised death rate from motor neuron disease (MND has increased from 1.29 to 2.74 per 100,000, an increase of 112.4% between 1959 and 2013. It is clear that genetics could not have played a causal role in the increased rate of MND deaths over such a short time span. We postulate that environmental factors are responsible for this rate increase. We focus on lead additives in Australian petrol as a possible contributing environmental factor. Methods: The associations between historical petrol lead emissions and MND death trends in Australia between 1962 and 2013 were examined using linear regressions. Results: Regression results indicate best fit correlations between a 20 year lag of petrol lead emissions and age-standardised female death rate (R2 = 0.86, p = 4.88 × 10−23, male age standardised death rate (R2 = 0.86, p = 9.4 × 10−23 and percent all cause death attributed to MND (R2 = 0.98, p = 2.6 × 10−44. Conclusion: Legacy petrol lead emissions are associated with increased MND death trends in Australia. Further examination of the 20 year lag between exposure to petrol lead and the onset of MND is warranted.

  17. [Removal Kinetics and Mechanism of Aniline by Manganese-oxide-modified Diatomite].

    Science.gov (United States)

    Xiao, Shao-dan; Liu, Lu; Jiang, Li-ying; Chen, Jian-meng

    2015-06-01

    A novel rapid green one-step method was developed for the preparation of manganese modified diatomite (Mn-D) by treating roasted diatomite with an acidic permanganate solution. The effects of calcination temperature and mass ratio of KMnO4 and diatomite (p) on aniline removal efficiency of Mn-D were investigated. The removal kinetics and mechanism of aniline by Mn-D were also discussed. The results showed that when the optimal calcination temperature was 450 degrees C, p was 1.6, and the loading amounts of δ-MnO2 was 0.82 g x g(-1), Mn-D had a great performance for aniline removal, and more than 80% of aniline was adsorbed within 10 minutes, accompanied with the release of Mn2+. In acidic conditions, the adsorption process on Mn-D followed pseudo-second-order and was mainly controlled by intra-particle diffusion. The best fitting of the experimental adsorption data was given by the Freundlich equation. Gas chromatograph-mass spectrometer was applied to identify the reaction intermediates at different times, and azobenzene was found to be the main reaction intermediate in the degradation system. Based on the above observations, the possible degradation pathway of aniline by Mn-D was proposed.

  18. Effect of Furan Fatty Acids and 3-Methyl-2,4-nonanedione on Light-Induced Off-Odor in Soybean Oil.

    Science.gov (United States)

    Sano, Takashi; Okabe, Ryo; Iwahashi, Maiko; Imagi, Jun; Sato, Toshiro; Yamashita, Toshiyuki; Fukusaki, Eiichiro; Bamba, Takeshi

    2017-03-15

    Soybean oil is one of the most widely consumed vegetable oils. However, under photooxidative conditions, this oil develops a beany and green off-odor through a mechanism that has not yet been elucidated. Upon photooxidation, 3-methyl-2,4-nonanedione (3-MND) produces a strong aroma. In this study, the effect of furan fatty acids and 3-MND on odor reversion in soybean oil was investigated. Our findings suggest that the observed light-induced off-odor was likely attributable to the furan fatty acids present in the oil through the generation of 3-MND. While 3-MND may not be directly responsible for the development of light-induced off-odor, this compound appears to be involved because off-odor was detected in canola oil samples containing added 3-MND. In addition, in the present work, 3-hydroxy-3-methyl-2,4-nonanedione, which is derived from 3-MND, was identified for the first time in light-exposed soybean oil and shown to be one of the compounds responsible for odor reversion.

  19. The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma.

    Science.gov (United States)

    Ito, Yasuhiro; Miyauchi, Akira; Kudo, Takumi; Kihara, Minoru; Fukushima, Mitsuhiro; Miya, Akihiro

    2017-09-01

    The most frequent recurrence site of papillary thyroid carcinoma (PTC) is the cervical lymph nodes. The introduction of an electric linear probe for use with ultrasonography in 1996 improved preoperative lateral neck evaluations. Before 2006, however, our hospital routinely performed prophylactic modified neck dissection (p-MND) for N0 or N1a PTCs >1 cm to prevent node recurrence. In 2006, we changed our policy and the indications for p-MND to PTCs >3 cm and/or with significant extrathyroid extension. Here, we retrospectively compared lymph node recurrence-free survival between PTCs with/without p-MND. We examined the cases of N0 or N1 and M0 PTC patients who underwent initial surgery in 1992-2012. To compare lymph node recurrence-free survival between patients who did/did not undergo p-MND, we divided these patients into three groups (excluding those whose surgery was in 2006): the 2045 patients whose surgery was performed in 1992-1996 (Group 1), the 2989 with surgery between 1997 (post-introduction of ultrasound electric linear probes) and 2005 (Group 2), and the 5332 operated on in 2007-2012 (Group 3). The p-MND performance rate of Group 3 (9%) was much lower than that of Group 1 (80%), but the lymph node recurrence-free survival of the former was significantly better, probably due to differences in clinical features and neck evaluations by ultrasound between the two groups. Our analysis of the patients aged Abolishing routine p-MND for PTCs in 2006 did not decrease lymph node recurrence-free survival, probably due to improved ultrasound preoperative neck evaluations and clinical feature changes. Selective p-MND for high-risk cases improved lymph node recurrence-free survival.

  20. The MY NASA DATA Project: Preparing Future Earth and Environmental Scientists, and Future Citizens

    Science.gov (United States)

    Chambers, L. H.; Phelps, C. S.; Phipps, M.; Holzer, M.; Daugherty, P.; Poling, E.; Vanderlaan, S.; Oots, P. C.; Moore, S. W.; Diones, D. D.

    2008-12-01

    For the past 5 years, the MY NASA DATA (MND) project at NASA Langley has developed and adapted tools and materials aimed at enabling student access to real NASA Earth science satellite data. These include web visualization tools including Google Earth capabilities, but also GPS and graphing calculator exercises, Excel spreadsheet analyses, and more. The project team, NASA scientists, and over 80 classroom science teachers from around the country, have created over 85 lesson plans and science fair project ideas that demonstrate NASA satellite data use in the classroom. With over 150 Earth science parameters to choose from, the MND Live Access Server enables scientific inquiry on numerous interconnected Earth and environmental science topics about the Earth system. Teachers involved in the project report a number of benefits, including networking with other teachers nationwide who emphasize data collection and analysis in the classroom, as well as learning about other NASA resources and programs for educators. They also indicate that the MND website enhances the inquiry process and facilitates the formation of testable questions by students (a task that is typically difficult for students to do). MND makes science come alive for students because it allows them to develop their own questions using the same data scientists use. MND also provides educators with a rich venue for science practice skills, which are often overlooked in traditional curricula as teachers concentrate on state and national standards. A teacher in a disadvantaged school reports that her students are not exposed to many educational experiences outside the classroom. MND allows inner city students to be a part of NASA directly. They are able to use the same information that scientists are using and this gives them inspiration. In all classrooms, the MND microsets move students out of their local area to explore global data and then zoom back into their homes realizing that they are a part of the

  1. Structural and functional brain signatures of C9orf72 in motor neuron disease.

    Science.gov (United States)

    Agosta, Federica; Ferraro, Pilar M; Riva, Nilo; Spinelli, Edoardo Gioele; Domi, Teuta; Carrera, Paola; Copetti, Massimiliano; Falzone, Yuri; Ferrari, Maurizio; Lunetta, Christian; Comi, Giancarlo; Falini, Andrea; Quattrini, Angelo; Filippi, Massimo

    2017-09-01

    This study investigated structural and functional magnetic resonance imaging abnormalities in hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) motor neuron disease (MND) relative to disease severity-matched sporadic MND cases. We enrolled 19 C9orf72 and 67 disease severity-matched sporadic MND patients, and 22 controls. Sporadic cases were grouped in patients with: no cognitive/behavioral deficits (sporadic-motor); same patterns of cognitive/behavioral impairment as C9orf72 cases (sporadic-cognitive); shorter disease duration versus other sporadic groups (sporadic-early). C9orf72 patients showed cerebellar and thalamic atrophy versus all sporadic cases. All MND patients showed motor, frontal, and temporoparietal cortical thinning and motor and extramotor white matter damage versus controls, independent of genotype and presence of cognitive impairment. Compared with sporadic-early, C9orf72 patients revealed an occipital cortical thinning. C9orf72 patients had enhanced visual network functional connectivity versus sporadic-motor and sporadic-early cases. Structural cerebellar and thalamic damage and posterior cortical alterations are the brain magnetic resonance imaging signatures of C9orf72 MND. Frontotemporal cortical and widespread white matter involvement are likely to be an effect of the disease evolution rather than a C9orf72 marker. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Record linkage between hospital discharges and mortality registries for motor neuron disease case ascertainment for the Spanish National Rare Diseases Registry.

    Science.gov (United States)

    Ruiz, Elena; Ramalle-Gómara, Enrique; Quiñones, Carmen

    2014-06-01

    Our objective was to analyse the coverage of hospital discharge data and the mortality registry (MR) of La Rioja to ascertain motor neuron disease (MND) cases to be included in the Spanish National Rare Diseases Registry. MND cases that occurred in La Rioja during the period 1996-2011 were selected from hospital discharge data and the MR by means of the International Classification of Diseases. Review of the medical histories was carried out to confirm the causes of death reported. Characteristics of the population with MND were analysed. A total of 133 patients with MND were detected in La Rioja during the period 1996-2011; 30.1% were only recorded in the hospital discharges data, 12.0% only in the MR, and 57.9% were recorded by both databases. Medical records revealed a miscoding of patients who had been diagnosed with progressive supranuclear palsy but were recorded in the MR with an MND code. In conclusion, the hospital discharges data and the MR appear to be complementary and are valuable databases for the Spanish National Rare Diseases Registry when MNDs are properly codified. Nevertheless, it would be advisable to corroborate the validity of the MR as data source since the miscoding of progressive supranuclear palsy has been corrected.

  3. Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres.

    Science.gov (United States)

    Ross, Jacob A; Pearson, Adam; Levy, Yotam; Cardel, Bettina; Handschin, Christoph; Ochala, Julien

    2017-06-01

    Muscle fibres are multinucleated cells, with each nucleus controlling the protein synthesis in a finite volume of cytoplasm termed the myonuclear domain (MND). What determines MND size remains unclear. In the present study, we aimed to test the hypothesis that the level of expression of the transcriptional coactivator PGC-1α and subsequent activation of the mitochondrial biogenesis are major contributors. Hence, we used two transgenic mouse models with varying expression of PGC-1α in skeletal muscles. We isolated myofibres from the fast twitch extensor digitorum longus (EDL) and slow twitch diaphragm muscles. We then membrane-permeabilised them and analysed the 3D spatial arrangements of myonuclei. In EDL muscles, when PGC-1α is over-expressed, MND volume decreases; whereas, when PGC-1α is lacking, no change occurs. In the diaphragm, no clear difference was noted. This indicates that PGC-1α and the related mitochondrial biogenesis programme are determinants of MND size. PGC-1α may facilitate the addition of new myonuclei in order to reach MND volumes that can support an increased mitochondrial density. J. Cell. Physiol. 232: 1270-1274, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  4. Being Yourself and Thinking About the Future in People With Motor Neuron Disease: A Grounded Theory of Self-care Processes.

    Science.gov (United States)

    Bassola, Barbara; Sansone, Valeria Ada; Lusignani, Maura

    2018-06-01

    Self-care is a crucial aspect in the management of people with motor neuron disease (MND). Nurses and healthcare professionals must know the processes used by patients in performing self-care to identify problems and help them. Decision-making processes, self-understanding, and political and social support influence the self-care process in chronic diseases. Little is known about the self-care process in MND. The aim of this study was to gain insight on the self-care processes in people with MND. A grounded theory method was chosen for this study. Data from interviews were gathered, and a simultaneous comparative analysis was conducted to identify categories and codes. Twenty-one people with spinal muscular atrophy and amyotrophic lateral sclerosis participated in the study. Five categories were identified as grounded in the data. The process starts from "being yourself in the care," and it develops thanks to "growing and changing" and with a "thinking about the future" approach. "Family role" and "you and who helps you" categories affect the process itself. The self-care process in people with MND is not seen in a daily perspective but changes with the evolution of the disease. For the growing patients with MND, changing, accepting and controlling the disease while deciding autonomously are the foundations of the process.

  5. Sorption of Cr(III) ion from aqueous solution by two kinds of modified diatomite.

    Science.gov (United States)

    Li, Er; Zeng, Xiangying

    2012-01-01

    Raw diatomite modified by microemulsion (DMM) and manganese oxide (MnD) were used for the removal of Cr(III) ions from aqueous solution. The characteristics and performance of these two types of modified diatomite on Cr(III) ion adsorption were compared. The results indicate that the Cr(III) ion adsorption capacities of diatomite were considerably improved after modifications by manganese oxide (MnO) and microemulsion. The surface area of MnD was increased because of the formation of MnO on the diatomite surface, and that of DMM was promoted owing to the existence of the hydrolyzed aromatic acid. Because of the stronger surface ionized function, the adsorption performance of Cr(III) ions in DMM was better than that in MnD. Within the experimental range of pH (i.e. 2.2-6.3), the Cr(III) ion removal of DMM (35-70%) was higher than that of MnD (33-59%) owing to the different electrostatic forces between the Cr(III) ion and the surface of the modified diatomite. The Cr(III) ion removal in MnD and DMM was improved with the increase of synthetic solution concentration in volumes from 0 to 2,500 mL.

  6. Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy

    DEFF Research Database (Denmark)

    Gredal, O; Rosenbaum, S; Topp, S

    1997-01-01

    We performed proton magnetic resonance spectroscopy (1H-MRS) in patients with motor neuron disease (MND) to determine the absolute in vivo concentrations in the brain of the metabolites N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr/PCr). We examined the spectra acquired from a 20 x 20 x...... subjects. We estimated the concentrations of the metabolites using the water signal as an internal standard. The concentrations of Cho and Cr/PCr in both brain regions, as well as the concentration of NAA in the cerebellum, were unaltered in the MND patients compared with the controls. Only MND patients...... with both upper and lower motor neuron signs had a significantly decreased concentration of NAA (9.13 +/- 0.28 mM, mean +/- SEM) in the primary motor cortex when compared with healthy controls (10.03 +/- 0.22 mM). In conclusion, the slightly decreased concentration of NAA in the primary motor cortex from...

  7. Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?

    Science.gov (United States)

    Delva, Aline; Thakore, Nimish; Pioro, Erik P; Poesen, Koen; Saunders-Pullman, Rachel; Meijer, Inge A; Rucker, Janet C; Kissel, John T; Van Damme, Philip

    2017-12-01

    Disturbances of eye movements are infrequently encountered in motor neuron diseases (MNDs) or motor neuropathies, and there is no known syndrome that combines progressive muscle weakness with downbeat nystagmus. To describe the core clinical features of a syndrome of MND associated with downbeat nystagmus, clinical features were collected from 6 patients. All patients had slowly progressive muscle weakness and wasting in combination with downbeat nystagmus, which was clinically most obvious in downward and lateral gaze. Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles. Visual complaints were not always present. Electrodiagnostic testing showed signs of regional motor axonal loss in all patients. The etiology of this syndrome remains elusive. Because finger extension weakness and downbeat nystagmus are the discriminating clinical features of this MND, we propose the name FEWDON-MND syndrome. Muscle Nerve 56: 1164-1168, 2017. © 2017 The Authors Muscle & Nerve Published by Wiley Periodicals, Inc.

  8. Efficacy of kinesiology tape versus postural correction exercises on neck disability and axioscapular muscles fatigue in mechanical neck dysfunction: A randomized blinded clinical trial.

    Science.gov (United States)

    El-Abd, Aliaa M; Ibrahim, Abeer R; El-Hafez, Haytham M

    2017-04-01

    Mechanical neck dysfunction (MND), with axioscapular muscles fatigue, is highly prevalent worldwide. While postural correction is commonly used for its treatment, efficacy of kinesiology tape (KT) has received considerable attention. To determine the effectiveness of KT versus correction exercises on neck disability, and axioscapular muscles fatigue in MND patients. 46 MND patients were randomly assigned into 1 of 2 groups receiving 4 weeks treatment of either KT or correction exercises. Neck disability and axioscapular muscles fatigue as median frequency of electromyography (EMG-MF) were measured pre and post treatment. Group-by-time interaction was not significant in the multivariable test. Post hoc tests revealed that KT produced more disability reduction than the postural exercises. However, there was no significant interaction for EMG-MF. KT has been found to be more effective than postural exercises to reduce neck disability. However, both modalities have similar effects to reduce axioscapular muscles fatigue. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Comparison of Performance of the VIP and WMT in a Criminal Forensic Sample.

    Science.gov (United States)

    Fazio, Rachel L; Denney, Robert L

    2018-01-24

    To compare the efficacy of the Validity Indicator Profile (VIP) and Word Memory Test (WMT) in a criminal forensic population. Potential participants included 225 male evaluees from a maximum-security Federal prison referred for neuropsychological evaluation for either forensic purposes or for suspected neurocognitive dysfunction as part of a medical evaluation. Examinees were included in the analysis if administered the VIP (Verbal, Nonverbal, or both tests) and WMT along with at least two other freestanding PVTs; 74 satisfied these criteria. Participants were then categorized as having probable Malingered Neurocognitive Dysfunction (+MND) if they failed at least two freestanding validity indicators, negative for MND (-MND) if they passed all indicators, and Possible MND (pMND) if they failed one indicator. Groups were very demographically similar. There were significant differences in WMT scores and distribution of VIP profiles across groups. Whether using traditional or investigative cut scores, and whether using the WMT with or without consideration of a GMIP profile, the WMT demonstrated superior sensitivity and specificity on nearly every comparison. The VIP, when interpreted in the traditional fashion, and the WMT with GMIP, both had more than adequate psychometric properties when used with criminal forensic evaluees, strengthening the body of literature supporting their use for these types of evaluations. Counting a positive on either of the VIP subtests as an indication of +MND improves the psychometric properties of the VIP slightly, although the WMT had the better overall classification accuracy. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. Is dignity therapy feasible to enhance the end of life experience for people with motor neurone disease and their family carers?

    Directory of Open Access Journals (Sweden)

    Bentley Brenda

    2012-09-01

    Full Text Available Abstract Background Development of interventions that address psychosocial and existential distress in people with motor neurone disease (MND or that alleviate caregiver burden in MND family carers have often been suggested in the research literature. Dignity therapy, which was developed to reduce psychosocial and existential distress at the end of life, has been shown to benefit people dying of cancer and their families. These results may not be transferable to people with MND. The objectives of this study are to assess the feasibility, acceptability and potential effectiveness of dignity therapy to enhance the end of life experience for people with motor neurone disease and their family carers. Methods/design This is a cross-sectional study utilizing a single treatment group and a pre/post test design. The study population will comprise fifty people diagnosed with MND and their nominated family carers. Primarily quantitative outcomes will be gathered through measures assessed at baseline and at approximately one week after the intervention. Outcomes for participants include hopefulness, spirituality and dignity. Outcomes for family carers include perceived caregiver burden, hopefulness and anxiety/depression. Feedback and satisfaction with the intervention will be gathered through a questionnaire. Discussion This detailed research will explore if dignity therapy has the potential to enhance the end of life experience for people with MND and their family carers, and fill a gap for professionals who are called on to address the spiritual, existential and psychosocial needs of their MND patients and families. Trial registration ACTRN Trial Number: ACTRN12611000410954

  11. Spatially complex distribution of dissolved manganese in a fjord as revealed by high-resolution in situ sensing using the autonomous underwater vehicle Autosub.

    Science.gov (United States)

    Statham, P J; Connelly, D P; German, C R; Brand, T; Overnell, J O; Bulukin, E; Millard, N; McPhail, S; Pebody, M; Perrett, J; Squire, M; Stevenson, P; Webb, A

    2005-12-15

    Loch Etive is a fjordic system on the west coast of Scotland. The deep waters of the upper basin are periodically isolated, and during these periods oxygen is lost through benthic respiration and concentrations of dissolved manganese increase. In April 2000 the autonomous underwater vehicle (AUV) Autosub was fitted with an in situ dissolved manganese analyzer and was used to study the spatial variability of this element together with oxygen, salinity, and temperature throughout the basin. Six along-loch transects were completed at either constant height above the seafloor or at constant depth below the surface. The ca. 4000 in situ 10-s-average dissolved Mn (Mnd) data points obtained provide a new quasi-synoptic and highly detailed view of the distribution of manganese in this fjordic environment not possible using conventional (water bottle) sampling. There is substantial variability in concentrations (600 nM) and distributions of Mnd. Surface waters are characteristically low in Mnd reflecting mixing of riverine and marine end-member waters, both of which are low in Mnd. The deeper waters are enriched in Mnd, and as the water column always contains some oxygen, this must reflect primarily benthic inputs of reduced dissolved Mn. However, this enrichment of Mnd is spatially very variable, presumably as a result of variability in release of Mn coupled with mixing of water in the loch and removal processes. This work demonstrates how AUVs coupled with chemical sensors can reveal substantial small-scale variability of distributions of chemical species in coastal environments that would not be resolved by conventional sampling approaches. Such information is essential if we are to improve our understanding of the nature and significance of the underlying processes leading to this variability.

  12. Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool.

    Science.gov (United States)

    Baxter, Susan; McDermott, Christopher J

    2017-05-08

    The diagnosis of motor neurone disease (MND) is known to be challenging and there may be delay in patients receiving a correct diagnosis. This study investigated the referral process for patients who had been diagnosed with MND, and whether a newly-developed tool (The Red Flags checklist) might help General Practitioners (GPs) in making referral decisions. We carried out interviews with GPs who had recently referred a patient diagnosed with MND, and interviews/surveys with GPs who had not recently referred a patient with suspected MND. We collected data before the Red Flags checklist was introduced; and again one year later. We analysed the data to identify key recurring themes. Forty two GPs took part in the study. The presence of fasciculation was the clinical feature that most commonly led to consideration of a potential MND diagnosis. GPs perceived that their role was to make onward referrals rather than attempting to make a diagnosis, and delays in correct diagnosis tended to occur at the specialist level. A quarter of participants had some awareness of the newly-developed tool; most considered it useful, if incorporated into existing systems. While fasciculation is the most common symptom associated with MND, other bulbar, limb or respiratory features, together with progression should be considered. There is a need for further research into how decision-support tools should be designed and provided, in order to best assist GPs with referral decisions. There is also a need for further work at the level of secondary care, in order that referrals made are re-directed appropriately.

  13. Suicide in patients with motor neuron disease

    DEFF Research Database (Denmark)

    Bak, Søren; Stenager, E N; Stenager, Egon

    1994-01-01

    The aim of the present study was to assess, through an epidemiological study, whether suicide risk is increased in patients with motor neuron disease (MND). The study involved 116 patients with MND. In the study period 92 patients died, 47 males and 45 females. No patients committed suicide....... The number of expected suicides was 0.27 for males and 0.12 for females, a total of 0.38. The difference between observed and expected suicides was not statistically significant for males and females....

  14. Molecular nonlinear dynamics and protein thermal uncertainty quantification

    Science.gov (United States)

    Xia, Kelin; Wei, Guo-Wei

    2014-01-01

    This work introduces molecular nonlinear dynamics (MND) as a new approach for describing protein folding and aggregation. By using a mode system, we show that the MND of disordered proteins is chaotic while that of folded proteins exhibits intrinsically low dimensional manifolds (ILDMs). The stability of ILDMs is found to strongly correlate with protein energies. We propose a novel method for protein thermal uncertainty quantification based on persistently invariant ILDMs. Extensive comparison with experimental data and the state-of-the-art methods in the field validate the proposed new method for protein B-factor prediction. PMID:24697365

  15. 运动神经元病%Motor Neuron Disease

    Institute of Scientific and Technical Information of China (English)

    蒋雨平

    2014-01-01

    Motor neuron disease (MND) represents a group of sporadic or genetic neurodegenerative diseases which principally affect the motor neurons and result in progressive paralysis and death. The epidemiology, genetics, clinical manifestation, diagnostic criteria of MND were reviewed.%运动神经元病是一组散发或遗传的神经变性病。主要累及运动神经元,病程进展而死亡。文中就其临床表现和诊断标准、流行病学和遗传学进行综述。

  16. Racial differences in motor neuron disease

    Science.gov (United States)

    GUNDOGDU, BETUL; AL-LAHHAM, TAWFIQ; SPENCER, HORACE; RUDNICKI, STACY A.

    2014-01-01

    Our objective was to compare and contrast clinical features of black and white patients seen in the UAMS ALS/Motor Neuron Disease (MND) clinic from January 2001 to December 2010. Death certificate information was reviewed to determine race of Arkansans who died of ALS/MND between 1999 and 2006. We used a retrospective chart review of patients with ALS/MND seen at least once in our clinic and reviewed state death certificate data. Results showed that from 1999 to 2006, 466 Arkansas deaths were attributed (immediate or contributory) to ALS/MND; 17 (3.6%) were black, four (0.9%) other, and 445 (95.5%) white. During this period, the proportion of black Arkansans was 17%. From 2001 to 2010, we saw 330 patients with ALS/MND: 30 (9.1%) black, six (1.8%) other, 294 (89.1%) white. Average onset age for whites was 58.1 ± 12.4 years, for blacks 52.8 ± 13.0 (p = 0.038). Gender, onset site, time from symptom onset to first clinic visit and initial vital capacity were similar between the groups. Initial ALSFRS-R was 37.5 ± 7.2 for whites and 30.8 ± 8.5 (p = 0.004) for blacks. A first or second degree relative with ALS/MND was reported by 8.1% of whites and by none of the black patients (p = 0.15). Riluzole, PEG and non-invasive ventilation use was similar between the groups. Median tracheostomy-free survival was 36 months for white and 40 months for black patients (p = 0.475). In conclusion, although blacks appear relatively spared from ALS/MND, they present at an earlier age and are functionally worse at their first visit. Investigating the genetic make-up of blacks with the disease may help identify genes that modify risk of developing ALS/MND. PMID:24067242

  17. Study on antioxidant experiment on forged steel tube sheet and tube hole for steam generator

    International Nuclear Information System (INIS)

    Zong Hai; Wang Detai; Ding Yang

    2012-01-01

    Antioxidant experiment on forged steel tube sheet and tube hole for steam generator was studied and the influence of different simulated heat treatments on the antioxidant performance of tube sheet and tube hole was made. The influence of different antioxidant methods on the size of tube hole was drawn. Furthermore, the change of size and weight of 18MnD5 forged steel tube sheet on the condition of different simulated heat treatments was also studied. The analytical results have proved reference information for the use of 18MnD5 material and for key processes of processing tube hole and wearing and expanding U-style tube. (authors)

  18. Teatri aastaauhindade nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  19. 1970. aastatel alustas arhitektidest sõprade ja kolleegide rühm... / Mari Laanemets

    Index Scriptorium Estoniae

    Laanemets, Mari, 1975-

    2008-01-01

    27.VI avatakse Eesti Arhitektuurimuuseumis Rotermanni soolalaos 1970. ja 1980. alguse eksperimentaalset arhitektuuripraktikat käsitlev näitus "Keskkond, objektid, kontseptsioonid. Tallinna kooli arhitektid 1972-1985". Näha saab Ülevi Eljandi, Ignar Fjuki, Veljo Kaasiku, Tiit Kaljundi, Vilen Künnapu, Leonhard Lapini, Avo-Himm Looveere, Kristin-Mari Looveere, Marika Lõokese, Jüri Okase, Jaan Olliku, Ain Padriku, Toomas Reinu, Andres Ringo, Sirje Runge, Harry Sheini, Tõnis Vindi ja Matti Õunapuu töid. Näituse kuraatorid Andres Kurg ja Mari Laanemets. Samas: "Uue arhitektuuri näituse programm" (1972)

  20. Lugemis- ja kuulamissoovitusi lapsemeelsetele : [heliraamatud ja -plaadid lastele] / Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2010-01-01

    Arvustus: Jancis, Kaspar. Seiklus Salamandril, ehk, Morten Viksi uskumatud juhtumised lollide laevas. Tallinn : Menu Kirjastus, 2010 ; Kivirähk, Andrus. Kaka ja kevad [Helisalvestis] / loeb Ülle Kaljuste. Tallinn ; Varrak, 2010 ; Kivirähk, Andrus. Kaelkirjak [Helisalvestis] / loeb Harriet Toompere. Tallinn : Varrak, 2010 ; Tungal, Leelo. Hea lapse laulud [Helisalvestis]. Tallinn : Nõmmelill, 2010 ; Pajusaar, Priit. Lapsed, liblikad ja teised mutukad [Helisalvestis]. Tallinn : Varrak, 2010 ; Toman, Eduard. Gena ja teised : [Helisalvestis]. Tallinn : Greenroom Studio, 2010 ; Vilmusenaho, Marika. Tuulejutu viisid [Helisalvestis] / esitavad Meero Muusiku laululapsed. I.k. : Tempo Rubato, 2009 ; Raud, Eno. Sipsik : laste unejutud / loeb Salme Reek. Tallinn : Eesti Rahvusringhääling, 2010

  1. Hea teater lastele ja noortele / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2006-01-01

    22.-27. maini Tallinnas, Tartus, Pärnus, Narvas toimunud laste- ja noortetatrite festivalist "Draamake 2006". Nimetatud auhinnasaajad : lastelavastuse auhinna sai Vanemuise "Suur kuri hunt" (lavastaja Taago Tubin), noorsooteatri auhind määrati Vene Teatri lavastusele "Veerevad kivid ei sammaldu" (lavastaja Nikita Grinshpun), näitlejaauhinnaga pärjati Marika Vaarikut osatäitmise eest VAT Teatri lavastuses "Klammi sõda", publikupuudutuse auhinna sai ZUGA ühendatud tantsijate "ZUGA lastekas" ja sõnajõuauhind läks NO99 teatri lavastusele "Kaks päikest" (lavastaja Andres Noormets)

  2. Vanemuise "Suur kuri hunt" valiti parimaks lastelavastuseks / Brigitta Davidjants

    Index Scriptorium Estoniae

    Davidjants, Brigitta, 1983-

    2006-01-01

    27. mail lõppenud laste- ja noorteteatrite festivalist "Draamake 2006". Lastelavastuse auhinna sai Vanemuise "Suur kuri hunt" (lavastaja Taago Tubin), noorsooteatri auhind määrati Vene Teatri lavastusele "Veerevad kivid ei sammaldu" (lavastaja Nikita Grinshpun), näitlejaauhinnaga pärjati Marika Vaarikut osatäitmise eest VAT Teatri lavastuses "Klammi sõda", publikupuudutuse auhinna sai ZUGA ühendatud tantsijate "ZUGA lastekas" ja sõnajõuauhind läks NO99 teatri lavastusele "Kaks päikest"( lavastaja Andres Noormets)

  3. Tudengite küsitlus: kas Aruküla säilitab identiteedi või muutub Tallinna magalaks / Ere Uibo

    Index Scriptorium Estoniae

    Uibo, Ere

    2017-01-01

    Aruküla elaniku Cristina Kaska eestvedamisel tegid Tallinna Ülikooli tudengid Aruküla elukeskkonna teemal küsitluse ja uurimistöö. Cristina Kaska õpib Tallinna Ülikoolis magistriõppes haridustehnoloogiat, uurimisgrupis osalesid ka Marika Kundla, Elle Altmets, Kadi Kasepõld ja Heret Annus. Uuringuga selgitati välja elanike rahulolu Aruküla heakorra, korteriühistute ja vallavalitsuse tööga ning nende endi valmisolek panustada heakorra parandamisse

  4. Kolmene ülikool esitles professoreid ja kirjanduspreemia laureaate

    Index Scriptorium Estoniae

    2008-01-01

    Tallinna Ülikool esitles 3. aastapäeva aktusel aasta jooksul professoreiks valituid: Lorenzo Cañás Bottos, Jyrki Käkönen, Aaro Toomela, Airi Värnik, Marika Mägi, Priit Reiska, Eve Kikas ja Karsten Brüggemann. Selgusid ka tänavused Tallinna Ülikooli kirjanduspreemia laureaadid. Algupärase ilukirjanduse vallas pälvis auhinna romanist, luuletaja ja tõlkija, doktorant Maarja Kangro, tõlkepreemia sai kirjanik ja tõlkija Arvo Valton

  5. TÜ, TPÜ ja EHI uusi magistreid / Eda Tursk, Hille Roots, Heidi Meier

    Index Scriptorium Estoniae

    Tursk, Eda

    2004-01-01

    Tartu ülikooli eesti ja soome-ugri keeleteaduse osakonnas ning kirjanduse ja rahvaluule osakonnas kaitsesid 2003.a. magistritööd Niina Aasmäe, Piret Voll, Larissa Degel, Reet Hendrikson, Tiina Pai, Petar Kehayov, Anna Baidullina, Katrin Ennus, Kristi Jõesaar, Ell Vahtramäe, Lauri Sommer, Andreas Kalkun, Mirjam Hinrikus, Kristel Nõlvak. Tallinna Pedagoogikaülikoolis kaitsesid 2003.a. magistritööd Sirje Nootre, Merike Mägedi, Tiiu Koovit, Heidi Meier, Jaanika Stackhouse, Lilian Ossi, Annika Vamper, Marika Mikkor, Piret Õunapuu, Helin Puksand, Taimi Rosenberg. Eesti Humanitaarinstituudis kaitses 2003.a. magistritööd Merilin Miljan

  6. Teatri aastaauhindadele kandideerijad selgunud

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  7. 4 maja lugu / Tiina Kolk

    Index Scriptorium Estoniae

    Kolk, Tiina

    2006-01-01

    Keskaegses kaupmeheelamus Lai tänav 23 paikneb Tallinna Linnateater (taastamistööde juht Teddy Böckler). Endisesse raadiotehasesse Punane RET Tallinnas on ehitatud Sampo panga peakontor (arhitektid Jüri Okas ja Marika Lõoke). Tartus Munga tänaval Eesti Panga Tartu majas (arhitektid Arnold Matteus ja Karl Burman, uue ruumiprogrammi kavandajad Uko Künnap ja Aivar Roosaar) asub Eesti Vabariigi Haridusministeerium. Pärnus endises Herman Leopold Ammende eramus (Peterburi arhitektuuribüroo Mieritz & Gerassimov, renoveeris Aivar Roosaar) asub hotell

  8. Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.

    Science.gov (United States)

    Ng, Louisa; Khan, Fary; Young, Carolyn A; Galea, Mary

    2017-01-10

    Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. To summarise the evidence from Cochrane Systematic Reviews of all symptomatic treatments for MND. We searched the Cochrane Database of Systematic Reviews (CDSR) on 15 November 2016 for systematic reviews of symptomatic treatments for MND. We assessed the methodological quality of the included reviews using the Assessment of Multiple Systematic Reviews (AMSTAR) tool and the GRADE approach. We followed standard Cochrane study (review) selection and data extraction procedures. We reported findings narratively and in tables. We included nine Cochrane Systematic Reviews of interventions to treat symptoms in people with MND. Three were empty reviews with no included randomised controlled trials (RCTs); however, all three reported on non-RCT evidence and the remaining six included mostly one or two studies. We deemed all of the included reviews of high methodological quality. Drug therapy for painThere is no RCT evidence in a Cochrane Systematic Review exploring the efficacy of drug therapy for pain in MND. Treatment for crampsThere is evidence (13 RCTs, N = 4012) that for the treatment of cramps in MND, compared to placebo:- memantine and tetrahydrocannabinol (THC) are probably ineffective (moderate-quality evidence);- vitamin E may have little or no effect (low-quality evidence); and- the effects of L-threonine, gabapentin, xaliproden, riluzole, and baclofen are uncertain as the evidence is either very low quality or the trial specified the outcome but did not report numerical data.The review reported adverse effects of riluzole, but it is not clear whether other interventions had adverse effects. Treatment for spasticityIt is uncertain whether an endurance-based exercise programme improved spasticity or quality of life, measured at three months after the

  9. Hamilton Park Care Facility, Balrothery, Balbriggan, Co. Dublin.

    LENUS (Irish Health Repository)

    Galvin, Miriam

    2018-01-27

    Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and emotional impact of providing care in the home requires appropriate assistance and support. The objective of this analysis is to explore the needs of informal ALS caregivers across the caregiving course.

  10. Synthèse: Revue des Sciences et de la Technologie - Vol 17 (2008)

    African Journals Online (AJOL)

    Modélisation numérique d'un phénomène mécanique (TRIP) induit par une transformation martensitique dans l'acier 16MND5 · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Mefta, L Taleb, F Barbe, F Sidoroff, 73-84 ...

  11. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

    Directory of Open Access Journals (Sweden)

    Mina Mahdavi

    2016-07-01

    Full Text Available Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt % and medical grade nanodiamonds (MND (3 nm; up to 3 wt %. Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa−1·s−1·m−1. The nanodiamond-modified mats are potentially suitable for wound healing applications.

  12. Rupther: a simulation approach applied to a PWR vessel failure during a severe accident

    International Nuclear Information System (INIS)

    Mongabure, Ph.; Nicolas, L.; Devos, J.

    2000-01-01

    The Rupther program (Rupture Under Thermal Conditions) is a part of the international researches on severe accidents in the PWR type reactors. The aim of the program is the definition of failure simulation validated by experimental data on vessel steel 16MND5 mechanical properties. The paper presents the program and the first results. (A.L.B.)

  13. Analysis on energy consumption of drying process for dried Chinese noodles

    International Nuclear Information System (INIS)

    Wang, Zhenhua; Zhang, Yingquan; Zhang, Bo; Yang, Fuguang; Yu, Xiaolei; Zhao, Bo; Wei, Yimin

    2017-01-01

    Highlights: • Energy analysis of a tunnel dryer for dried Chinese noodles is completed. • Energy saving performance of dryers with different inlet air was compared. • MND was developed and evaluated, and the efficiency and throughput was improved. - Abstract: Drying is an important operation during the production of dried Chinese noodles, and the energy consumption from drying accounts for approximately 60% of the total energy consumption during the manufacturing process. To investigate the energy consumption and throughput of dryers for dried Chinese noodles, experiments were conducted using a new 130-m long tunnel dryer with two lines of noodles (ND) and an old 60-m long tunnel dryer with five lines of noodles (OD). The energy saving effects of a modified new 130-m long tunnel dryer (MND), which was only modified through the inclusion of automatic control for temperature and humidity without any modifications to the oil heater or ND dryer structure, were also compared. The energy saving effect was determined from the enthalpy difference between the inlet and outlet humid air of the ND and MND. Finally, the MND was found to be better than ND in terms of energy efficiency and throughput, and trends for the future of noodle drying were discussed.

  14. Amyotrophic lateral sclerosis presenting with orthopnea in a patient with COPD and obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    T.L.N. Swamy

    2011-01-01

    Full Text Available Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease (MND is a relentlessly progressive neurological disorder causing peripheral muscular weakness and resultant respiratory failure. In this article, we report a case of ALS with chronic obstructive pulmonary disease (COPD and obstructive sleep apnea (OSA with orthopnea as initial symptoms.

  15. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

    Science.gov (United States)

    Mahdavi, Mina; Mahmoudi, Nafiseh; Rezaie Anaran, Farzad; Simchi, Abdolreza

    2016-01-01

    Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa−1·s−1·m−1. The nanodiamond-modified mats are potentially suitable for wound healing applications. PMID:27399726

  16. Handwriting, visuomotor integration, and neurological condition at school age

    NARCIS (Netherlands)

    van Hoorn, Jessika F.; Maathuis, Carel G. B.; Peters, Lieke H. J.; Hadders-Algra, Mijna

    2010-01-01

    Aim The study investigated the relationships between handwriting, visuomotor integration, and neurological condition. We paid particular attention to the presence of minor neurological dysfunction (MND). Method Participants were 200 children (131 males, 69 females; age range 8-13y) of whom 118

  17. The Effects of Motor Neurone Disease on Language: Further Evidence

    Science.gov (United States)

    Bak, Thomas H.; Hodges, John R.

    2004-01-01

    It might sound surprising that Motor Neurone Disease (MND), regarded still by many as the very example of a neurodegenerative disease affecting selectively the motor system and sparing the sensory functions as well as cognition, can have a significant influence on language. In this article we hope to demonstrate that language dysfunction is not…

  18. Motor neuron disease: the impact of decreased speech intelligibility ...

    African Journals Online (AJOL)

    Background: The onset of motor neuron disease (MND), a neurodegenerative disease, results in physical and communication disabilities that impinge on an individual's ability to remain functionally independent. Multiple aspects of the marital relationship are affected by the continuously changing roles and responsibilities.

  19. Risk factors for motor neuron diseases : genes, environment and lifestyle

    NARCIS (Netherlands)

    Sutedja, N.A.

    2010-01-01

    The main focus of this thesis is to identify susceptibility factors in diseases affecting the motor neuron: both motor neuron disease (MND), in which primarily the cell body is affected, and multifocal motor neuropathy (MMN), in which primarily the axon is affected, are covered. Due to its

  20. Neurological condition assessed with the Hempel examination and cognition and behaviour at 4 years

    NARCIS (Netherlands)

    Schendelaar, Pamela; Seggers, Jorien; Heineman, Maas Jan; Hadders-Algra, Mijna

    Aim: To investigate associations between neurological condition, assessed with the Hempel examination, in terms of minor neurological dysfunction (MND) and neurological optimality, and cognition and behaviour at 4 years. Study design: Cross-sectional analyses within a prospective, assessor-blinded

  1. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Science.gov (United States)

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  2. An Exploratory Study of Software Cost Estimating at the Electronic Systems Division.

    Science.gov (United States)

    1976-07-01

    action’. to improve the software cost Sestimating proces., While thin research was limited to the M.nD onvironment, the same types of problema may exist...Methods in Social Science. Now York: Random House, 1969. 57. Smith, Ronald L. Structured Programming Series (Vol. XI) - Estimating Software Project

  3. A Framework for Failure? The Impact of Short Tour Lengths and Separate National Command and Control on British Operational Art and Coalition Warfare in Iraq, 2003-2009

    Science.gov (United States)

    2013-12-10

    frame the problem.54 This is a clear example of cognitive dissonance and highlights the intellectual confusion that had emerged in senior British...to explicitly express complete satisfaction with PJHQ and the command and control framework) came from LTG Riley, CG MND (SE) from Dec 04-Jun 05: LTG

  4. Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome.

    Science.gov (United States)

    Bak, T H; O'Donovan, D G; Xuereb, J H; Boniface, S; Hodges, J R

    2001-01-01

    We report six patients with clinically diagnosed and electrophysiologically confirmed motor neurone disease (MND), in whom communication problems were an early and dominant feature. All patients developed a progressive non-fluent aphasia culminating in some cases in complete mutism. In five cases, formal testing revealed deficits in syntactic comprehension. Comprehension and production of verbs were consistently more affected those that of nouns and this effect remained stable upon subsequent testing, despite overall deterioration. The classical signs of MND, including wasting, fasciculations and severe bulbar symptoms, occurred over the following 6-12 months. The behavioural symptoms ranged from mild anosognosia to personality change implicating frontal-lobe dementia. In three cases, post-mortem examination has confirmed the clinical diagnosis of MND-dementia. In addition to the typical involvement of motor and premotor cortex, particularly pronounced pathological changes were observed in the Brodmann areas 44 (Broca's area) and 45. The finding of a selective impairment of verb/action processing in association with the dementia/aphasia syndrome of MND suggests that the neural substrate underlying verb representation is strongly connected to anterior cortical motor systems.

  5. Interactions of Aging, Overload, and Creatine Supplementation in Rat Plantaris Muscle

    Directory of Open Access Journals (Sweden)

    Mark D. Schuenke

    2011-01-01

    Full Text Available Attenuation of age-related sarcopenia by creatine supplementation has been equivocal. In this study, plantaris muscles of young (Y; 5m and aging (A; 24m Fisher 344 rats underwent four weeks of either control (C, creatine supplementation (Cr, surgical overload (O, or overload plus creatine (OCr. Creatine alone had no effect on muscle fiber cross-sectional area (CSA or heat shock protein (HSP70 and increased myonuclear domain (MND only in young rats. Overload increased CSA and HSP70 content in I and IIA fibers, regardless of age, and MND in IIA fibers of YO rats. CSA and MND increased in all fast fibers of YOCr, and CSA increased in I and IIA fibers of AOCr. OCR did not alter HSP70, regardless of age. MND did not change in aging rats, regardless of treatment. These data indicate creatine alone had no significant effect. Creatine with overload produced no additional hypertrophy relative to overload alone and attenuated overload-induced HSP70 expression.

  6. Handwriting, Visuomotor Integration, and Neurological Condition at School Age

    Science.gov (United States)

    Van Hoorn, Jessika F.; Maathuis, Carel G. B.; Peters, Lieke H. J.; Hadders-Algra, Mijna

    2010-01-01

    Aim: The study investigated the relationships between handwriting, visuomotor integration, and neurological condition. We paid particular attention to the presence of minor neurological dysfunction (MND). Method : Participants were 200 children (131 males, 69 females; age range 8-13y) of whom 118 received mainstream education (mean age 10y 5mo, SD…

  7. Mutant ApoA-1 Amyloidosis in a Family of Five Siblings With Motor Neuron Disease and Dementia

    DEFF Research Database (Denmark)

    Vrethema, Magnus; Mucchiano, Gerd Ingrid

    2011-01-01

    We present a family of fi ve siblings in which three brothers died of motor neuron disease (MND) and in two of them concomitant with dementia. A fourth brother died of myocardial infarction and was found to have extensive aortic intimal apolipoprotein A-1 (ApoA-1) derived amyloid deposits and apo...

  8. Test-retest, inter-assessor and intra-assessor reliability of the modified Touwen examination

    NARCIS (Netherlands)

    Peters, Lieke H. J.; Maathuis, Karel G. B.; Kouw, Eva; Hamming, Marjolein; Hadders-Algra, Mijna

    Interest in the Touwen examination (1979) for the assessment of minor neurological dysfunction (MND) is growing. However, information on psychometric properties of this assessment is scarce. Therefore the present study aimed at assessing the test's test-retest, inter- and intra-assessor reliability.

  9. Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis.

    LENUS (Irish Health Repository)

    Galvin, Miriam

    2018-01-27

    Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and emotional impact of providing care in the home requires appropriate assistance and support. The objective of this analysis is to explore the needs of informal ALS caregivers across the caregiving course.

  10. Quality of general movements and the development of minor neurological dysfunction at toddler and school age

    NARCIS (Netherlands)

    Hadders-Algra, M; Mavinkurve-Groothuis, AMC; Stremmelaar, EF; Martijn, A; Butcher, PR; Groen, S.E

    Objective: To evaluate the reliability of assessing infants' general movements (GMs) using a new classification and its validity in predicting complex minor neurological dysfunction (MND) at toddler and at school age. Design: Prospective study of two groups of infants, each consisting of a mix of

  11. Negotiating the Nation in History: the Swedish State Approval Scheme for Textbooks and Teaching Aids from 1945 to 1983

    Science.gov (United States)

    Elmersjö, Henrik Åström

    2016-01-01

    This article explores the discussions concerning history textbooks that occurred within the Swedish State Approval Scheme for Textbooks (Statens läroboksnämnd) from 1945 to 1983. By focusing on the negotiation of nationhood and the process of textbook approval as an arena for the renegotiation of ways in which history was taught in schools, the…

  12. Aerobic exercise and congnitive behavioural therapy in ALS: optimzing quality of life

    NARCIS (Netherlands)

    van der Lans-van Groenestijn, A.C.

    2017-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal progressive adult-onset neurodegenerative motor neuron disease (MND). In the absence of an effective treatment, ALS care focuses on symptom treatment, optimizing functioning (daily activities and social participation) and maintaining quality of life

  13. Mechanical cough augmentation techniques in amyotrophic lateral sclerosis/motor neuron disease

    OpenAIRE

    Rafiq, M.K.; Bradburn, M.; Mustfa, N.; Mcdermott, C.J.; Annane, D.

    2016-01-01

    © 2016 The Cochrane Collaboration.This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of mechanical insufflator/exsufflator (MI-E) and the breath-stacking technique for reducing morbidity and mortality and enhancing quality of life in people with amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

  14. Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

    NARCIS (Netherlands)

    Gaastra, Benjamin; Shatunov, Aleksey; Pulit, Sara; Jones, Ashley R; Sproviero, William; Gillett, Alexandra; Chen, Zhongbo; Kirby, Janine; Fogh, Isabella; Powell, John F; Leigh, P Nigel; Morrison, Karen E; Shaw, Pamela J; Shaw, Christopher E; van den Berg, Leonard H; Veldink, Jan H; Lewis, Cathryn M; Al-Chalabi, Ammar

    2016-01-01

    Our objective was to identify whether rare genetic variation in amyotrophic lateral sclerosis (ALS) candidate survival genes modifies ALS survival. Candidate genes were selected based on evidence for modifying ALS survival. Each tail of the extreme 1.5% of survival was selected from the UK MND DNA

  15. A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

    Energy Technology Data Exchange (ETDEWEB)

    Salek, Reza M.; Pears, Michael R. [University of Cambridge, Department of Biochemistry and Cambridge Systems Biology Centre (United Kingdom); Cooper, Jonathan D. [King' s College London, Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry (United Kingdom); Mitchison, Hannah M. [Royal Free and University College Medical School, Department of Paediatrics and Child Health (United Kingdom); Pearce, David A. [Sanford School of Medicine of the University of South Dakota, Department of Pediatrics (United States); Mortishire-Smith, Russell J. [Johnson and Johnson PR and D (Belgium); Griffin, Julian L., E-mail: jlg40@mole.bio.cam.ac.uk [University of Cambridge, Department of Biochemistry and the Cambridge Systems Biology Centre (United Kingdom)

    2011-04-15

    The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in {gamma}-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.

  16. Millimeter Wave Attenuation in Moist Air: Laboratory Measurements and Analysis.

    Science.gov (United States)

    1984-03-01

    generation of incoherent noise, Mnd wavelengths. (e) scintillitions due to random fluctuations of the medium in space and time. The array of mathematical ...calculations are for observations in the zenith direction free air is very empty. The molecular radius r -1.5 x ICI-4 Lem. groud lvel Coaic aditio of

  17. TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

    NARCIS (Netherlands)

    Cairns, Nigel J.; Neumann, Manuela; Bigio, Eileen H.; Holm, Ida E.; Troost, Dirk; Hatanpaa, Kimmo J.; Foong, Chan; White, Charles L.; Schneider, Julie A.; Kretzschmar, Hans A.; Carter, Deborah; Taylor-Reinwald, Lisa; Paulsmeyer, Katherine; Strider, Jeffrey; Gitcho, Michael; Goate, Alison M.; Morris, John C.; Mishrall, Manjari; Kwong, Linda K.; Stieber, Anna; Xu, Yan; Forman, Mark S.; Trojanowski, John Q.; Lee, Virginia M.-Y.; Mackenzie, Ian R. A.

    2007-01-01

    TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) with or without motor neuron disease (MND). Thus, TDP-43 defines a novel class of neurodegenerative diseases called

  18. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins.

    Science.gov (United States)

    Mahdavi, Mina; Mahmoudi, Nafiseh; Rezaie Anaran, Farzad; Simchi, Abdolreza

    2016-07-07

    Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa(-1)·s(-1)·m(-1). The nanodiamond-modified mats are potentially suitable for wound healing applications.

  19. A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

    International Nuclear Information System (INIS)

    Salek, Reza M.; Pears, Michael R.; Cooper, Jonathan D.; Mitchison, Hannah M.; Pearce, David A.; Mortishire-Smith, Russell J.; Griffin, Julian L.

    2011-01-01

    The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in γ-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.

  20. Incidence of and risk factors for Motor Neurone Disease in UK women: a prospective study

    Directory of Open Access Journals (Sweden)

    Doyle Pat

    2012-05-01

    Full Text Available Abstract Background Motor neuron disease (MND is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors. Methods 1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models. Findings During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 – 2·7 to 12·5 (95% CI 10·2 – 15·3 per 100,000 women aged 50–54 to 70–74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03. There was a statistically significant reduction in risk of MND with increasing body mass index (pfor trend = 0·009: obese women (body mass index, 30 kg/m2 or more had a 20% lower risk than women of normal body mass index (20 to 2(RR 0·78 95% CI 0·65-0·94; p = 0·03. This effect persisted after exclusion of the first three years of follow-up. Interpretation MND incidence in UK women rises rapidly with age, and an estimated 1 in 575 women are likely to be affected between the ages of 50 and 75 years. Smoking slightly increases the risk of MND, and adiposity in middle age is associated with a lower risk of the disease.

  1. Deformed Fluvial Terraces of Little Rock Creek Capture Off-Fault Strain Adjacent to the Mojave Section of the San Andreas Fault

    Science.gov (United States)

    Moulin, A.; Scharer, K. M.; Cowgill, E.

    2017-12-01

    Examining discrepancies between geodetic and geomorphic slip-rates along major strike-slip faults is essential for understanding both fault behavior and seismic hazard. Recent work on major strike-slip faults has highlighted off-fault deformation and its potential impact on fault slip rates. However, the extent of off-fault deformation along the San Andreas Fault (SAF) remains largely uncharacterized. Along the Mojave section of the SAF, Little Rock Creek drains from south to north across the fault and has cut into alluvial terraces abandoned between 15 and 30 ka1. The surfaces offer a rare opportunity to both characterize how right-lateral slip has accumulated along the SAF over hundreds of seismic cycles, and investigate potential off-fault deformation along secondary structures, where strain accumulates at slower rates. Here we use both field observations and DEM analysis of B4 lidar data to map alluvial and tectonic features, including 9 terrace treads that stand up to 80 m above the modern channel. We interpret the abandonment and preservation of the fluvial terraces to result from episodic capture of Little Rock Creek through gaps in a shutter ridge north of the fault, followed by progressive right deflection of the river course during dextral slip along the SAF. Piercing lines defined by fluvial terrace risers suggest that the amount of right slip since riser formation ranges from 400m for the 15-ka-riser to 1200m for the 30-ka-riser. Where they are best-preserved NE of the SAF, terraces are also cut by NE-facing scarps that trend parallel to the SAF in a zone extending up to 2km from the main fault. Exposures indicate these are fault scarps, with both reverse and normal stratigraphic separation. Geomorphic mapping reveals deflections of both channel and terrace risers (up to 20m) along some of those faults suggesting they could have accommodated a component of right-lateral slip. We estimated the maximum total amount of strike-slip motion recorded by the

  2. Determinants of accepting non-invasive ventilation treatment in motor neurone disease: a quantitative analysis at point of need.

    Science.gov (United States)

    Cousins, Rosanna; Ando, Hikari; Thornton, Everard; Chakrabarti, Biswajit; Angus, Robert; Young, Carolyn

    2013-01-01

    Objectives : Motor neurone disease (MND) progressively damages the nervous system causing wasting to muscles, including those used for breathing. There is robust evidence that non-invasive ventilation (NIV) relieves respiratory symptoms and improves quality of life in MND. Nevertheless, about a third of those who would benefit from NIV decline the treatment. The purpose of the study was to understand this phenomenon. Design : A cross-sectional quantitative analysis. Methods : Data including age, sex, MND symptomatology, general physical and mental health and psychological measures were collected from 27 patients and their family caregivers at the point of being offered ventilatory support based on physiological markers. Results : Quantitative analyses indicated no difference in patient characteristics or symptomatology between those who tolerated ( n  = 17) and those who declined ( n  = 10) NIV treatment. A comparison of family caregivers found no differences in physical or mental health or in caregiving distress, emphasising that this was high in both groups; however, family caregivers supporting NIV treatment were significantly more resilient, less neurotic and less anxious than family caregivers who did not. Regression analyses, forcing MND symptoms to enter the equation first, found caregiver resilience:commitment the strongest predictor of uptake of NIV treatment adding 22% to the 56% explained variance. Conclusion : Patients who tolerated NIV treatment had family caregivers who cope through finding meaning and purpose in their situation. Psychological support and proactive involvement for family caregivers in the management of the illness situation is indicated if acceptance of NIV treatment is to be maximised in MND.

  3. Nutritional advice and treatment by dietitians to patients with amyotrophic lateral sclerosis/motor neurone disease: a survey of current practice in England, Wales, Northern Ireland and Canada.

    Science.gov (United States)

    Rio, A; Cawadias, E

    2007-02-01

    The management of amyotrophic lateral sclerosis/motor neurone disease (ALS/MND) has shifted from an attitude of nihilism to treatments that prolong survival and offer hope. Nutrition is an integral component of ALS/MND care requiring coordination among acute and community multi-disciplinary teams (MDT). Evidence-based nutrition guidelines exist for this patient group but their use among dietitians is unknown. The aim of this study was to survey the knowledge, practice and guideline use of dietitians working in ALS/MND centres/clinics across England, Wales, Northern Ireland (EWNI) and Canada. Dietetic contact details were obtained from the Motor Neurone Disease Association (MNDA) and the ALS Society of Canada (ALSSC) websites. Telephone interviews were conducted with 23 dietitians using a standardized questionnaire. Multi-disciplinary team membership was high (78%). Only 22% dietitians had >4-years experience in ALS/MND care. Dietitians reported using body weight, percentage weight loss (PWL) and body mass index (BMI) to assess nutritional status. Equations used to estimate energy and protein requirements differed. Most frequent dietary advice was high calorie, texture modification and prescription nutritional supplements. Artificial nutrition and hydration (ANH) was discussed when patients developed dysphagia, energy intake was inadequate, weight loss of 10% or forced vital capacity (FVC) was reduced. A percutaneous endoscopic gastrostomy (PEG) service was available at all clinics/centres. Nutritional assessment techniques and dietary advice should be standardized. Dietetic collaboration at national and international level is recommended to reduce professional isolation. Training and support in ALS/MND nutrition should be made available as part of post-dietetic registration. Further dietetic research is required to stimulate nutritional care.

  4. Experiences and reflections of patients with motor neuron disease on breaking the news in a two-tiered appointment: a qualitative study.

    Science.gov (United States)

    Seeber, Antje A; Pols, A Jeannette; Hijdra, Albert; Grupstra, Hepke F; Willems, Dick L; de Visser, Marianne

    2016-02-02

    Breaking bad news should be fine-tuned to the individual patient, contain intelligible information, include emotional support and offer a tailor-made treatment plan. To achieve this goal in motor neuron disease (MND), neurologists of the amyotrophic lateral sclerosis (ALS) centre Amsterdam deliver the message on 2 separate visits within 14 days. To evaluate how patients with MND react to and view disclosure of the diagnosis, in this 2-tiered approach. Non-participating observations and in-depth interviews with patients were conducted in 1 tertiary ALS referral centre. Qualitative analysis consisted of inductive analysis of observation reports and verbatim typed out interviews. 10 2-tiered appointments were observed and 21 Dutch patients with MND interviewed. They experienced the straightforward message to be suffering from a fatal disease as devastating, yet unavoidable. The prospect of a short-term second appointment offered structure for the period immediately following the diagnosis. The time between appointments provided the opportunity for a first reorientation on their changed perspective on their life. The second appointment allowed for detailed discussions about various aspects of MND and a tailor-made treatment plan. The 2-tiered approach fits well with the way in which Dutch patients with MND process the disclosure of their diagnosis, gather information and handle the changed perspective on their life. It may serve as a model for other life-limiting diseases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  5. Frontotemporal lobar degeneration with ubiquitin pathology: an autopsy case presenting with semantic dementia and upper motor neuron signs with a clinical course of 19 years.

    Science.gov (United States)

    Yokota, Osamu; Tsuchiya, Kuniaki; Itoh, Yoshinori; Ishizu, Hideki; Akiyama, Haruhiko; Ikeda, Manabu; Kuzuhara, Shigeki; Otomo, Eiichi

    2006-12-01

    We report a case of a right-handed 74-year-old man who showed semantic dementia with a disease duration of 19 years. He initially presented with excessive use of pronouns and semantic paraphasia at the age of 55 years. Impairment of object recognition developed 5 years after the onset. Face recognition impairment and stereotypic behaviors developed 11 years after onset, and pyramidal signs 2 years before death. Pathological examination disclosed circumscribed severe atrophy in not only the bilateral temporal tips but also in the left precentral gyrus and pars opercularis in a motor speech field. Pyramidal tract involvement and loss of Betz cells were also evident. On the other hand, neurons in the anterior horns and hypoglossal nuclei were spared in number, although astrocytes were mildly proliferated. Ubiquitin-positive lesions were observed in the hippocampus, and frontal and temporal cortices. Neither Bunina bodies nor Pick bodies were present. These features clinically fit the international diagnostic criteria of semantic dementia and, histopathologically, frontotemporal lobar degeneration with motor neuron disease (FTLD-MND). This case suggests that (1) the distribution of cortical lesions associated with language disturbance is not uniform in FTLD-MND. It may be that only some cases of FTLD with ubiquitin pathology develop semantic dementia despite the high incidence of language disturbance, and (2) the precentral gyrus can be severely affected in FTLD-MND. After reviewing previous cases of FTLD-MND with a clinical course of more than 10 years, we also noticed that (3) FTLD-MND cases with a long disease duration often show upper motor neuron-predominant involvement.

  6. Relationships between myonuclear domain size and fibre properties in the muscles of Thoroughbred horses.

    Science.gov (United States)

    Kawai, M; Kuwano, A; Hiraga, A; Miyata, H

    2010-11-01

    The myonuclear domain (MND) is the region of cytoplasm governed by a single myonucleus. Myonuclear domain size is an important factor for muscle fibre plasticity because each myonucleus has limitations in the capacity of protein synthesis. Previous studies have demonstrated that differences in MND size exist in different fibre types in several species, including horses. To understand the basic mechanism of muscle plasticity, the relationships between MND size, muscle fibre type population and metabolic properties of skeletal muscles throughout the whole body in Thoroughbred horses were examined. Post mortem samples were taken from 20 muscles in 3 Thoroughbred horses aged 3-5 years of age. Fibre type population was determined on serial cross sections of each muscle sample, stained for monoclonal antibodies to each myosin heavy chain isoform. Oxidative (succinic dehydrogenase; SDH) and glycolytic (phosphofructokinase; PFK) enzyme activities were determined spectrophotometrically in each muscle sample. Furthermore, 30 single fibres were isolated from each muscle under stereomicroscopy and then fibre volume and myonuclear number for a given length analysed under confocal microscopy. The MND size of each single fibre was measured after normalisation of sarcomere length to 2.8 µm by staining with membrane-specific dye. Immunohistochemical staining indicated that soleus, vastus lateralis and gluteus medius muscles had the highest percentage of type I, IIa and IIx muscle fibre, respectively. Biochemical analysis indicated highest activities of SDH and PFK in diaphragm and longissimus lumborum muscles, respectively. MNDs were largest in the splenius muscle and smallest in the soleus and masseter muscles. Myonuclear domain size is significantly related to type I muscle fibre population, but not to SDH activities of the muscles. The MND size of muscle fibre depends on fibre type population rather than mitochondrial enzyme activities. © 2010 EVJ Ltd.

  7. Ag/MnO₂ Nanorod as Electrode Material for High-Performance Electrochemical Supercapacitors.

    Science.gov (United States)

    Guo, Zengcai; Guan, Yuming; Dai, Chengxiang; Mu, Jingbo; Che, Hongwei; Wang, Guangshuo; Zhang, Xiaoliang; Zhang, Zhixiao; Zhang, Xiliang

    2018-07-01

    A one-dimensional hierarchical Ag nanoparticle (AgNP)/MnO2 nanorod (MND) nanocomposite was synthesized by combining a simple solvothermal method and a facile reduction approach in situ. Owing to its high electrical conductivity, the resulting AgNP/MND nanocomposite displayed a high specific capacitance of 314 F g-1 at a current density of 2 A g-1, which was much higher than that of pure MNDs (178 F g-1). Resistances of the electrolyte (Rs) and charge transportation (Rct) of the nanocomposite were much lower than that of pure MNDs. Moreover, the nanocomposite exhibited outstanding long-term cycling ability (9% loss of initial capacity after 1000 cycles). These results indicated that the nanocomposite could serve as a promising and useful electrode material for future energy-storage applications.

  8. The Genetics of Monogenic Frontotemporal Dementia

    Directory of Open Access Journals (Sweden)

    Leonel T. Takada

    Full Text Available ABSTRACTAround 10-15% of patients diagnosed with frontotemporal dementia (FTD have a positive family history for FTD with an autosomal dominant pattern of inheritance. Since the identification of mutations in MAPT(microtubuleassociated protein tau gene in 1998, over 10 other genes have been associated with FTD spectrum disorders, discussed in this review. Along with MAPT, mutations in GRN(progranulin and C9orf72(chromosome 9 open reading frame 72 are the most commonly identified in FTD cohorts. The association of FTD and motor neuron disease (MND can be caused by mutations in C9orf72and other genes, such as TARDBP(TAR DNA-binding protein, FUS(fused in sarcoma, UBQLN2(ubiquilin 2. Multisystem proteinopathy is a complex phenotype that includes FTD, Paget disease of the bone, inclusion body myopathy and MND, and can be due to mutations in VCP(valosing containing protein and other recently identified genes.

  9. EMG analysis in 78 cases with motor neuron disease

    Institute of Scientific and Technical Information of China (English)

    Zhang Qiubin

    2000-01-01

    This paper analysed the FMGs of 78 cases with the motor neuron disease(MND). The EMG of all patients showed following characteristics that the average duration of wave prolonged, the average voltage increased and it was found that fibrillation and fasciculatton potentials appeared spontaneously. The fibrillation potential of ENG waa related to course of disease. In the patients whose course of disease was short, the fibri llation potential increased obviously, while in the cases of chronic MND, It usually decreased. The motor nerve conduction velocity of most pa tients (41%) reduced, however, the sensory nerve conduction velocity was normal but two. We reviewed some references about EMG of the motor neuron disease and discussed their characteristics and mechanism

  10. Data Redistribution through MY NASA DATA: Striving to bring authentic NASA data into education

    Science.gov (United States)

    Lewis, P. M.; Oostra, D.; Oots, P.; Chambers, L. H.; Moore, S.; Crecelius, S.; Taylor, J.

    2012-12-01

    The Mentoring and inquirY using NASA Data on Atmospheric and Earth science for Teachers and Amateurs (MY NASA DATA or MND) project was launched in 2004 to bring authentic data into K-12 education. The MND website features a Live Access Server (LAS), an open source tool which allows users to customize data sets to suit their individual needs, choosing from among 200 global Level 3 data sets. Approximately 120 lesson plans that utilize the available parameters are offered to help teachers and students get started with data exploration. Grade appropriate data documentation is also provided (with continual efforts to improve it to better meet the needs of this target audience). Through inquiry and lesson utilization, educators have several connection points to the data. As classrooms shift to problem-based and inquiry learning, the need for a data visualizer/server increases. Through numerous and growing connections to NASA satellite missions, and with access to data as a built-in feature, MND effectively fills this niche to provide a first level of data re-use that is friendly to the K-12 community. Offering a wide variety of data sets allows MND to support many science topics within the K-12 curriculum while extending the use of scientific data from NASA Earth science satellites. Lessons, created by educators across the country, allow MND to connect with the classroom teacher and to meet their data needs. As technology continues to evolve, a second level of data re-use becomes both interesting and possible. Thus, the MND team is now exploring new web and mobile platforms that can be built and distributed on an accelerated time cycle to keep up with information technology developments. With implementation of these new platforms come challenges in promoting new items to the education community, the public, and other potential users. Included in the list of challenges are: ever-evolving technology, prediction of the market, web/mobile platforms, and time-to-market for

  11. Amyotrophic lateral sclerosis or not: Keys for the diagnosis.

    Science.gov (United States)

    Lenglet, T; Camdessanché, J-P

    2017-05-01

    Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease (MND) which prognosis is poor. Early diagnosis permit to set up immediately adapted treatment and cares. Available diagnostic criteria are based on the detection of both central and peripheral motor neuron injury in bulbar, cervical, thoracic and lumbar regions. Electrodiagnostic (EDX) tests are the key tools to identify peripheral motor neuron involvement. Needle examination records abnormal activities at rest, and looks for neurogenic pattern during muscle contraction. Motor unit potentials morphology is modified primary to recruitment. Motor evoked potentials remain the test of choice to identify impairment of central motor neurons. In the absence of diagnostic biomarker of ALS and among essential investigations of suspected MND, a careful clinical and neurophysiological work-up is essential to rule out the differential diagnosis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. Teatri aastaauhindade laureaadid 2007

    Index Scriptorium Estoniae

    2007-01-01

    Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind. Ka Kuressaares toimunud teatripeost

  13. Eesti teatri aastaauhinnad 2006. aasta loomingu eest

    Index Scriptorium Estoniae

    2007-01-01

    Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind

  14. Eesti teatri aastaauhinnad 2006

    Index Scriptorium Estoniae

    2007-01-01

    Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind

  15. The management of amyotrophic lateral sclerosis.

    LENUS (Irish Health Repository)

    Phukan, Julie

    2009-02-01

    The terms amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) refer to a condition characterized by motor system degeneration with relative preservation of other pathways. Although there have been advances in symptomatic treatment, ALS remains an incurable condition. Advances in ALS management prolong survival but simultaneously raise challenging ethical dilemmas for physicians, patients and their families. Here, we review current practice in the management of ALS including pharmacological treatment, nutritional management, respiratory care, and evolving strategies in the management of cognitive impairment.

  16. 75 FR 12802 - Notice of Availability of Calendar Year 2011 Competitive Grant Funds

    Science.gov (United States)

    2010-03-17

    ... administering Federal funds provided for civil legal services to low-income people. LSC hereby announces the...-2, NNM-4 New York NY-9 North Dakota ND-3, MND, NND-3 Ohio OH-20, OH-18, OH-21, OH-23, MOH Oklahoma NOK-1 Pennsylvania PA-1, PA-24, MPA Puerto Rico PR-2 South Dakota SD-2, SD-4, MSD, NSD-1 Tennessee TN...

  17. Estimating the ROI on Implementation of RFID at the Ammunition Storage Warehouse and the 40th Supply Depot: KVA as a Methodology

    Science.gov (United States)

    2009-12-01

    Balanced Scorecard CAPM Capital Asset Pricing Model DIS Defense Information System DoD Department of...Measurement Tool (PMT) is the Balanced Scorecard (BSC) based on critical success factors and key performance indicators. The MND has referred to Jung’s...authors can replicate the methodology for multiple projects to generate a portfolio of projects. Similar to the Capital Asset Pricing Model ( CAPM ) or

  18. Electron correlation effects in the half-metallic NiMnSb within a cluster-perturbation approach with ab-initio parameters

    Directory of Open Access Journals (Sweden)

    H. Allmaier

    2008-06-01

    Full Text Available  Using a combination of electronic-structure and many-body calculations, we investigate correlations effects in the halfmetallic ferromagnet NiMnSb. A realistic many-body Hamiltonian, containing only Mn-d orbitals shows the importance of non-quasiparticle states just above the Fermi level. Our results suggest that for a better description of low energy states around Fermi level, Ni-d orbitals should be explicitly included.

  19. Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort.

    Science.gov (United States)

    Berlowitz, David J; Howard, Mark E; Fiore, Julio F; Vander Hoorn, Stephen; O'Donoghue, Fergal J; Westlake, Justine; Smith, Anna; Beer, Fiona; Mathers, Susan; Talman, Paul

    2016-03-01

    Respiratory failure is associated with significant morbidity and is the predominant cause of death in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). This study aimed to determine the effect of non-invasive ventilatory (NIV) support on survival and pulmonary function decline across MND/ALS phenotypes. Cohort recruited via a specialist, multidisciplinary clinic. Patients were categorised into four clinical phenotypes (ALS, flail arm, flail leg and primary lateral sclerosis) according to site of presenting symptom and the pattern of upper versus lower motor neurone involvement. NIV was initiated according to current consensus practice guidelines. Between 1991 and 2011, 1198 patients diagnosed with ALS/MND were registered. 929 patients (77.5%) fulfilled the selection criteria and their data were analysed. Median tracheostomy free survival from symptom onset was 28 months in NIV-treated patients compared to 15 months in untreated (Univariate Cox regression HR=0.61 (0.51 to 0.73), pNIV persisted when the model was adjusted for age, gender, riluzole and percutaneous endoscopic gastrostomy use (HR=0.72 (0.60 to 0.88, p=0.001). In contrast with the only randomised controlled trial, NIV statistically significantly increased survival by 19 months in those with ALS-bulbar onset (Univariate HR=0.50 (0.36 to 0.70), multivariate HR=0.59 (0.41 to 0.83)). These data confirm that NIV improves survival in MND/ALS. The overall magnitude of benefit is 13 months and was largest in those with ALS-bulbar disease. Future research should explore the optimal timing of NIV initiation within phenotypes in order to optimise respiratory function, quality of life and survival. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  20. A self-care, problem-solving and mindfulness intervention for informal caregivers of people with motor neurone disease: A pilot study.

    Science.gov (United States)

    Ugalde, Anna; Mathers, Susan; Hennessy Anderson, Nicole; Hudson, Peter; Orellana, Liliana; Gluyas, Cathy

    2018-04-01

    Informal caregivers of people with motor neurone disease (MND) take on an extensive role. Caregivers are at increased risk of experiencing psychological distress and burden, yet, there is a lack of intervention programmes to support them. The aim of this study was to investigate the feasibility and acceptability of a therapeutic group intervention promoting self-care, problem-solving and mindfulness to informal caregivers of people with MND. Pilot study that utilised a one-arm pre- and post-design. Acceptability of the intervention was assessed 2 weeks post intervention with a questionnaire designed specifically for this study. Feasibility was assessed with consent, adherence and reasons for non-participation, refusal and attrition. Participants completed baseline and follow-up (6-week post intervention) questionnaires for psychological morbidity, burden, problem-solving, mindfulness and preparedness. Settings/participants: Caregivers of people with a diagnosis of MND within the past 12 months who were 18 years or older; who could speak, read and write in English and who were attending a progressive neurological diseases clinic were eligible. A total of 13 caregivers participated in one of three group intervention sessions which were focused on self-care, problem-solving and mindfulness. The intervention appeared to be feasible and acceptable. All participants stated that they would recommend the intervention to others. The group format appeared to be highly valued. There was no significant change in measures between pre-intervention and 6 weeks post intervention. This pilot serves as an initial step for examining interventions for MND caregivers, with the hope of identifying effective, efficient and sustainable strategies to best support this group.

  1. Multidecadal trends in the nesting phenology of Pacific and Atlantic leatherback turtles are associated with population demography

    OpenAIRE

    Robinson, Nathan J.; Valentine, Sara E.; Santidrián Tomillo, Pilar; Saba, Vincent S.; Spotila, James R.; Paladino, Frank V.

    2013-01-01

    Knowledge of the mechanisms influencing phenology can provide insights into the adaptability of species to climate change. Here, we investigated the factors influencing multidecadal trends in the nesting phenology of the leatherback turtle Dermochelys coriacea at Playa Grande, Costa Rica, in the eastern Pacific Ocean and at Sandy Point, US Virgin Islands, in the western Atlantic Ocean. Between 1993 and 2013, the median nesting date (MND) at Playa Grande occurred later, at a rate of ~0.3 d yr-...

  2. Supporting wellbeing in motor neurone disease for patients, carers, social networks, and health professionals: A scoping review and synthesis.

    Science.gov (United States)

    Harris, Melanie; Thomas, Geoff; Thomas, Mary; Cafarella, Paul; Stocks, Allegra; Greig, Julia; McEvoy, R Doug

    2018-04-01

    ABSTRACTObjective:Disease management in motor neurone disease (MND) is focused on preserving quality of life. However, the emphasis has so far been on physical symptoms and functioning and not psychosocial wellbeing. MND affects the wellbeing of carers, of family and social network members, and of healthcare providers, as well as of the patients. We therefore aimed to assess and synthesize the knowledge about maximizing MND-related psychosocial wellbeing across all these groups. We used a systematic search and selection process to assess the scope of the literature along with a narrative synthesis of recent high-quality reviews. The original studies were mainly observational studies of patients and, to a lesser extent, of carers. There were few interventional studies, mainly of patients. There were very few studies of any type on wellbeing in their wider social network or in healthcare professionals. All the review literature looked at MND patient or carer wellbeing, with some covering both. No reviews were found of wellbeing in other family members, patients' social networks, or their healthcare professionals. The reviews demonstrated wellbeing problems for patients linked to psychosocial issues. Carer wellbeing is also compromised. Psychotherapies, social supports, improved decision supports, and changes to healthcare delivery are among the suggested strategies for improved patient and carer wellbeing, but no proven interventions were identified for either. Early access to palliative care, also not well-tested but recommended, is poorly implemented. Work on interventions to deal with well-established wellbeing problems for patients and carers is now a research priority. Explicit use of current methods for patient and public involvement and for design and testing of interventions provide a toolkit for this research. Observational research is needed in other groups. There is a potential in considering needs across patients' social networks rather than looking

  3. Sialorrhoea: How to Manage a Frequent Complication of Motor Neuron Disease

    OpenAIRE

    Andrea Pellegrini; Christian Lunetta; Carlo Ferrarese; Lucio Tremolizzo

    2015-01-01

    Sialorrhoea, the unintentional loss of saliva through the mouth, is the frequent complication of neurological disorders affecting strength or coordination of oropharyngeal muscles, such as motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) or Parkinson’s disease. Sialorrhoea might affect up to 42% of ALS patients, with almost half of them having poorly managed symptoms. Sialorrhoea can impair patients’ social life, while dermatological complications, such as skin rashes, may arise d...

  4. Predictive value of general movements' quality in low-risk infants for minor neurological dysfunction and behavioural problems at preschool age.

    Science.gov (United States)

    Bennema, Anne N; Schendelaar, Pamela; Seggers, Jorien; Haadsma, Maaike L; Heineman, Maas Jan; Hadders-Algra, Mijna

    2016-03-01

    General movement (GM) assessment is a well-established tool to predict cerebral palsy in high-risk infants. Little is known on the predictive value of GM assessment in low-risk populations. To assess the predictive value of GM quality in early infancy for the development of the clinically relevant form of minor neurological dysfunction (complex MND) and behavioral problems at preschool age. Prospective cohort study. A total of 216 members of the prospective Groningen Assisted Reproductive Techniques (ART) cohort study were included in this study. ART did not affect neurodevelopmental outcome of these relatively low-risk infants born to subfertile parents. GM quality was determined at 2 weeks and 3 months. At 18 months and 4 years, the Hempel neurological examination was used to assess MND. At 4 years, parents completed the Child Behavior Checklist; this resulted in the total problem score (TPS), internalizing problem score (IPS), and externalizing problem score (EPS). Predictive values of definitely (DA) and mildly (MA) abnormal GMs were calculated. DA GMs at 2 weeks were associated with complex MND at 18 months and atypical TPS and IPS at 4 years (all ppredictive value of DA GMs at 2 weeks were rather low (13%-60%); specificity and negative predictive value were excellent (92%-99%). DA GMs at 3 months occurred too infrequently to calculate prediction. MA GMs were not associated with outcome. GM quality as a single predictor for complex MND and behavioral problems at preschool age has limited clinical value in children at low risk for developmental disorders. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  5. Ahp2 (Hop2) function in Arabidopsis thaliana (Ler) is required for stabilization of close alignment and synaptonemal complex formation except for the two short arms that contain nucleolus organizer regions.

    Science.gov (United States)

    Stronghill, P; Pathan, N; Ha, H; Supijono, E; Hasenkampf, C

    2010-08-01

    A cytological comparative analysis of male meiocytes was performed for Arabidopsis wild type and the ahp2 (hop2) mutant with emphasis on ahp2's largely uncharacterized prophase I. Leptotene progression appeared normal in ahp2 meiocytes; chromosomes exhibited regular axis formation and assumed a typical polarized nuclear organization. In contrast, 4',6'-diamidino-2-phenylindole-stained ahp2 pachytene chromosome spreads demonstrated a severe reduction in stabilized pairing. However, transmission electron microscopy (TEM) analysis of sections from meiocytes revealed that ahp2 chromosome axes underwent significant amounts of close alignment (44% of total axis). This apparent paradox strongly suggests that the Ahp2 protein is involved in the stabilization of homologous chromosome close alignment. Fluorescent in situ hybridization in combination with Zyp1 immunostaining revealed that ahp2 mutants undergo homologous synapsis of the nucleolus-organizer-region-bearing short arms of chromosomes 2 and 4, despite the otherwise "nucleus-wide" lack of stabilized pairing. The duration of ahp2 zygotene was significantly prolonged and is most likely due to difficulties in chromosome alignment stabilization and subsequent synaptonemal complex formation. Ahp2 and Mnd1 proteins have previously been shown, "in vitro," to form a heterodimer. Here we show, "in situ," that the Ahp2 and Mnd1 proteins are synchronous in their appearance and disappearance from meiotic chromosomes. Both the Ahp2 and Mnd1 proteins localize along the chromosomal axis. However, localization of the Ahp2 protein was entirely foci-based whereas Mnd1 protein exhibited an immunostaining pattern with some foci along the axis and a diffuse staining for the rest of the chromosome.

  6. Finding Effective Responses Against Cyber Attacks for Divided Nations

    Science.gov (United States)

    2015-12-01

    Coordination Center LTE Long Term Evolution MAC Media Access Control MCRC Master Control and Reporting Center MEI Ministry of Electronics...satellites that aid Internet connections. Individual users can access the Internet via not only a wired connection up to 1 Gbps, but also by 4G LTE ...operate air-gapped intranets with security measures such as cryptographic modules that correspond to security levels. The MND does maintain the public

  7. United States Air Force Statistical Digest, Fiscal Year 1976 and Transition Quarter (TQ). 31st Edition

    Science.gov (United States)

    1977-04-30

    JMM JMP JPB JlO J11 KBD KBK KCF KCG KCK KCM KCQ KDB KDC KDF KDM KDQ KDR KEA KEB KEC KFB KFC KFS KFU KGL KGM KGN KGX KHD KND LBM LED MBK ITEM DESCRIPTION...KDF KD1’! KDQ KDR KEA KEB KEC KFC KFS KFU KGL KGM KGN KGX KHO KND LBI’ LED MBK MBN 1’!CE MCF MOB MEA MEB MEC MGX MND RBC RED SFJ SFK YFB 474 475 490

  8. Chemical Genetic Screens for TDP-43 Modifiers and ALS Drug Discovery

    Science.gov (United States)

    2015-03-01

    Champagne , and Pierre Drapeau. 25th international symposium on ALS/MND (5-7 December 2014) Patten SA, Vaccaro A, Drapeau P, Kabashi E, Parker JA...transgenic mice produced with TDP- 43 genomic fragments. Brain 134, 2610-2626 (2011). 6 Kabashi, E., Champagne , N., Brustein, E. & Drapeau, P. In the...swim of things: recent insights to neurogenetic disorders from zebrafish. Trends Genet 26, 373-381 (2010). 7 Kabashi, E., Brustein, E., Champagne , N

  9. Differential regional cerebral glucose metabolism in clinical syndromes of frontotemporal lobar degeneration: a study with FDG PET

    International Nuclear Information System (INIS)

    Park, J. M.; Cho, S. S.; Na, D. L.; Lee, K. H.; Choi, Y.; Choe, Y. S.; Kim, B. T.; Kim, S. E.

    2001-01-01

    Frontotemporal lobar degeneration( FTLD) is the third most common dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neurobehavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patient with FTLD presented with four different clinical syndromes. We analysed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral premotor are was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical features of FTLD syndromes. These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD

  10. Regional cerebral glucose metabolism in frontotemporal lobar degeneration

    International Nuclear Information System (INIS)

    Park, J.M.; Cho, S.S.; Lee, K.-H.; Choi, Y.; Choe, Y.S.; Kim, B.-T.; Kim, S.E.; Kwon, J.C.; Na, D.L.

    2002-01-01

    Purpose: Frontotemporal lobar degeneration (FTLD) is the third most common cause of dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neuro behavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patients with FTLD presented with four different clinical syndromes. Methods: We analyzed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Results: Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral pre-motor area was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical and neuropsychological features of FTLD syndromes. Conclusion: These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD

  11. Experience of long-term use of non-invasive ventilation in motor neuron disease: an interpretative phenomenological analysis.

    Science.gov (United States)

    Ando, Hikari; Chakrabarti, Biswajit; Angus, Robert M; Cousins, Rosanna; Thornton, Everard W; Young, Carolyn A

    2014-03-01

    Although non-invasive ventilation (NIV) can promote quality of life in motor neuron disease (MND), previous studies have disregarded the impact of progression of illness. This study explored how patients' perceptions of NIV treatment evolve over time and how this was reflected in their adherence to NIV. Five patients with MND (male=4, mean age=59 years), from a bigger cohort who were prospectively followed, had multiple post-NIV semistructured interviews, covering more than 12 months, along with ventilator interaction data. The transcribed phenomenological data were analysed using qualitative methodology. Three themes emerged: experience of NIV, influence on attitudes and perceived impact of NIV on prognosis. The ventilator interaction data identified regular use of NIV by four participants who each gave positive account of their experience of NIV treatment, and irregular use by one participant who at interview revealed a negative attitude to NIV treatment and in whom MND induced feelings of hopelessness. This exploratory study suggests that a positive coping style, adaptation and hope are key factors for psychological well-being and better adherence to NIV. More studies are needed to determine these relationships.

  12. Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector

    Directory of Open Access Journals (Sweden)

    Swati Singh

    2017-03-01

    Full Text Available Wiskott-Aldrich syndrome (WAS is a life-threatening immunodeficiency caused by mutations within the WAS gene. Viral gene therapy to restore WAS protein (WASp expression in hematopoietic cells of patients with WAS has the potential to improve outcomes relative to the current standard of care, allogeneic bone marrow transplantation. However, the development of viral vectors that are both safe and effective has been problematic. While use of viral transcriptional promoters may increase the risk of insertional mutagenesis, cellular promoters may not achieve WASp expression levels necessary for optimal therapeutic effect. Here we evaluate a self-inactivating (SIN lentiviral vector combining a chromatin insulator upstream of a viral MND (MPSV LTR, NCR deleted, dl587 PBS promoter driving WASp expression. Used as a gene therapeutic in Was−/− mice, this vector resulted in stable WASp+ cells in all hematopoietic lineages and rescue of T and B cell defects with a low number of viral integrations per cell, without evidence of insertional mutagenesis in serial bone marrow transplants. In a gene transfer experiment in non-human primates, the insulated MND promoter (driving GFP expression demonstrated long-term polyclonal engraftment of GFP+ cells. These observations demonstrate that the insulated MND promoter safely and efficiently reconstitutes clinically effective WASp expression and should be considered for future WAS therapy.

  13. Multimodal structural MRI in the diagnosis of motor neuron diseases.

    Science.gov (United States)

    Ferraro, Pilar M; Agosta, Federica; Riva, Nilo; Copetti, Massimiliano; Spinelli, Edoardo Gioele; Falzone, Yuri; Sorarù, Gianni; Comi, Giancarlo; Chiò, Adriano; Filippi, Massimo

    2017-01-01

    This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND) patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS), 44 patients with predominantly upper motor neuron disease (PUMN), 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT) MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis. In the training set, precentral cortical thickness showed 0.86 and 0.89 accuracy in differentiating ALS and PUMN patients from controls, while DT MRI distinguished the two groups from controls with 0.78 and 0.92 accuracy. In ALS vs controls, the combination of cortical thickness and DT MRI metrics (combined model) improved the classification pattern (0.91 accuracy). In the validation cohort, the best accuracy was reached by DT MRI (0.87 and 0.95 accuracy in ALS and PUMN vs mimic disorders). The combined model distinguished ALS and PUMN patients from mimic syndromes with 0.87 and 0.94 accuracy. A multimodal MRI approach that incorporates motor cortical and white matter alterations yields statistically significant improvement in accuracy over using each modality separately in the individual MND patient classification. DT MRI represents the most powerful tool to distinguish MND from mimic disorders.

  14. In silico analysis of β-mannanases and β-mannosidase from Aspergillus flavus and Trichoderma virens UKM1

    Science.gov (United States)

    Yee, Chai Sin; Murad, Abdul Munir Abdul; Bakar, Farah Diba Abu

    2013-11-01

    A gene encoding an endo-β-1,4-mannanase from Trichoderma virens UKM1 (manTV) and Aspergillus flavus UKM1 (manAF) was analysed with bioinformatic tools. In addition, A. flavus NRRL 3357 genome database was screened for a β-mannosidase gene and analysed (mndA-AF). These three genes were analysed to understand their gene properties. manTV and manAF both consists of 1,332-bp and 1,386-bp nucleotides encoding 443 and 461 amino acid residues, respectively. Both the endo-β-1,4-mannanases belong to the glycosyl hydrolase family 5 and contain a carbohydrate-binding module family 1 (CBM1). On the other hand, mndA-AF which is a 2,745-bp gene encodes a protein sequence of 914 amino acid residues. This β-mannosidase belongs to the glycosyl hydrolase family 2. Predicted molecular weight of manTV, manAF and mndA-AF are 47.74 kDa, 49.71 kDa and 103 kDa, respectively. All three predicted protein sequences possessed signal peptide sequence and are highly conserved among other fungal β-mannanases and β-mannosidases.

  15. Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells

    Directory of Open Access Journals (Sweden)

    Gérard Manière

    2016-09-01

    Full Text Available Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs sense leucine and regulate insulin secretion is still poorly understood. In Drosophila, insulin-like peptides (DILP2 and DILP5 are produced by brain IPCs and are released in the hemolymph after leucine ingestion. Using Ca2+-imaging and ex vivo cultured larval brains, we demonstrate that IPCs can directly sense extracellular leucine levels via minidiscs (MND, a leucine transporter. MND knockdown in IPCs abolished leucine-dependent changes, including loss of DILP2 and DILP5 in IPC bodies, consistent with the idea that MND is necessary for leucine-dependent DILP release. This, in turn, leads to a strong increase in hemolymph sugar levels and reduced growth. GDH knockdown in IPCs also reduced leucine-dependent DILP release, suggesting that nutrient sensing is coupled to the glutamate dehydrogenase pathway.

  16. Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosis/motor neuron disease.

    Science.gov (United States)

    Mahajan, Kedar R; Bach, John Robert; Saporito, Lou; Perez, Nick

    2012-12-01

    Although it is known that continuous noninvasive ventilation (CNIV) can prolong life in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), in this study we explore similar claims for diaphragm pacing (DP). NIV and DP users' vital capacities (VCs) over time and duration of NIV and CNIV dependence were analyzed for 354 non-DP and 8 DP ALS/MND patients. Patients had a higher rate of monthly VC decline before NIV use (5.1 ± 7.6%) than during NIV use (2.5 ± 3.6%) (P NIV for 19.9 ± 27.6 months until tracheostomy/death, whereas 113 others used it for 10.9 ± 10.5 months until CNIV dependence for another 12.8 ± 16.2 months. After placement, 7 DP users were CNIV dependent in 8.0 ± 7.0 months, whereas 6 underwent tracheostomy/died in 18.2 ± 13.7 months. CNIV prolonged the survival of 113 of the 354 non-DP and 6 DP ALS/MND patients by 12.8 and 10.2 months, respectively. DP provided no benefit on VC or mechanical ventilation-free survival. Copyright © 2012 Wiley Periodicals, Inc.

  17. Voltage-Gated Potassium Channel Antibodies in Slow-Progression Motor Neuron Disease.

    Science.gov (United States)

    Godani, Massimiliano; Zoccarato, Marco; Beronio, Alessandro; Zuliani, Luigi; Benedetti, Luana; Giometto, Bruno; Del Sette, Massimo; Raggio, Elisa; Baldi, Roberta; Vincent, Angela

    2017-01-01

    The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND). We compared 11 patients affected by slow-progression MND with 9 patients presenting typical progression illness. Sera were tested for VGKC-complex Abs by radioimmunoassay. The distribution of VGKC-complex Abs was analyzed with the Mann-Whitney U test. The statistical analysis showed a significant difference between the mean values in the study and control groups. A case with long-survival MND harboring VGKC-complex Abs and treated with intravenous immunoglobulins is described. Although VGKC-complex Abs are not likely to be pathogenic, these results could reflect the coexistence of an immunological activation in patients with slow disease progression. © 2016 S. Karger AG, Basel.

  18. Attitudes towards euthanasia and physician-assisted suicide among Pakistani and Indian doctors: A survey

    Directory of Open Access Journals (Sweden)

    Syed Qamar Abbas

    2008-01-01

    Full Text Available Aim: This study attempts to assess the attitude of Pakistani and Indian doctors to euthanasia and physician-assisted suicide. Methods: We used a questionnaire survey that included one case history of a patient with cancer and another of one suffering from motor neurone disease (MND. Results: Fifty-two of 100 doctors from Pakistan returned the completed questionnaires. Eight of the 52 (15.3% doctors agreed with the concept of euthanasia being an acceptable option for the patient with MND. Six of the 52 (11.5% supported a similar approach for the cancer patient. From India, 60/100 doctors returned the completed questionnaires. Sixteen of the 60 (26.6% doctors supported euthanasia as an option for the patient with MND whereas 15 (25% supported a similar option for the cancer patient. Conclusion: We conclude that only a minority of the doctors support euthanasia. This group belongs to a younger age group. In Pakistan, they were more likely to be males. The religion of the doctors did not appear to be a determining factor.

  19. Differential regional cerebral glucose metabolism in clinical syndromes of frontotemporal lobar degeneration: a study with FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. M.; Cho, S. S.; Na, D. L.; Lee, K. H.; Choi, Y.; Choe, Y. S.; Kim, B. T.; Kim, S. E. [College of Medicine, Sungkyunkwan Univ., Seoul (Korea, Republic of)

    2001-07-01

    Frontotemporal lobar degeneration( FTLD) is the third most common dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neurobehavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patient with FTLD presented with four different clinical syndromes. We analysed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral premotor are was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical features of FTLD syndromes. These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD.

  20. Why don't they accept non-invasive ventilation?: insight into the interpersonal perspectives of patients with motor neurone disease.

    Science.gov (United States)

    Ando, Hikari; Williams, Carl; Angus, Robert M; Thornton, Everard W; Chakrabarti, Biswajit; Cousins, Rosanna; Piggin, Lucy H; Young, Carolyn A

    2015-05-01

    Although non-invasive ventilation (NIV) can benefit survival and quality of life, it is rejected by a substantial proportion of people with motor neurone disease (MND). The aim of this study was to understand why some MND patients decline or withdraw from NIV. Nine patients with MND (male = 7, mean age = 67 years) participated in this study. These patients, from a cohort of 35 patients who were offered NIV treatment to support respiratory muscle weakness, did not participate in NIV treatment when it was clinically appropriate. Semi-structured interviews and interpretative phenomenological analysis (IPA) were employed to explore these patient's experience of MND and their thoughts and understanding of NIV treatment. Using IPA, four themes were identified: preservation of the self, negative perceptions of NIV, negative experience with health care services, and not needing NIV. Further analysis identified the fundamental issue to be the maintenance of perceived self, which was interpreted to consist of the sense of autonomy, dignity, and quality of life. The findings indicate psychological reasons for disengagement with NIV. The threat to the self, the sense of loss of control, and negative views of NIV resulting from anxiety were more important to these patients than prolonging life in its current form. These findings suggest the importance of understanding the psychological dimension involved in decision-making regarding uptake of NIV and a need for sensitive holistic evaluation if NIV is declined. Statement of contribution What is already known on this subject? Non-invasive ventilation is widely used as an effective symptomatic therapy in MND, yet about a third of patients decline the treatment. Psychological disturbance generated by NIV use leads to negative experiences of the treatment. Decision-making about treatment potentials is complex and unique to each individual affected by perceived impact of disease. What does this study add? A decision concerning

  1. Standalone cool/freeze cluster driven by solar photovoltaic energy. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Katic, I.; Pedersen, Per Henrik; Jacobsen, Emil

    2010-12-15

    The objective of the project is to develop and demonstrate a grid-independent cold storage system for perishable food, medicine or other goods, with a special focus on the need for such systems in developing countries with a sparse and unreliable supply of electricity. The project is directly based on the result from the international SolarChill project where a unique battery less solar driven vaccine refrigerator was developed by Vestfrost in cooperation with Danish Technological Institute (DTI). The project partners are Danish Technological Institute (Project manager), Danfoss, Grundfos, Fresvik (Norway) and Karise Klejnsmedie. The refrigeration system is set up at the solar energy test area of DTI, where a PV array with a nominal power of 800 W has been established. The batteries and charge controller are purchased from a Danish PV system retailer. The inverter is a trapezoid 50 Hz 230 Vac inverter is a robust type with high surge current. The two AC cabinets are standard low energy household freezers, whereas the DC cabinet is a special ice-lined refrigerator (fresh food/middle temperature) with high thermal capacity in its walls. The selection of large chest type freezers gives low specific energy consumption due to a high volume/surface ratio and low air infiltration. The commercial low energy cabinets are relatively inexpensive, and can operate with an extremely low consumption if the thermostat is set to cooling mode. As part of this quite extensive project, there have been a number of contacts with associated activities as well as direct requests from companies operating in 3rd world countries. The two most important cases have been a milk-cooling project in Uganda and a World Bank GEF project regarding improved storage methods for vaccines. The current design of the PV driven refrigeration system could be modified to milk cooling, and this is actually being investigated by the Danish company Karise Klejnsmedie who are specialist in stainless steel

  2. Therapeutical aspect of trichomoniasis

    Directory of Open Access Journals (Sweden)

    Vukićević Jelica

    2003-01-01

    Full Text Available Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole according to protocol recommended by Center for Disease Control (CDC formerly called: Communicable Disease Center [19]. The resistance of Trichomonas vaginalis (TV strains to metronidazole (MND was described in USA in 1960, and later on in many European countries [8, 9, 10, 11, 12, 13]. In these cases, due to persistent trichomonas infection, it is necessary to repeat MND treatment with moderate modification of dose and/or length of its application. Nevertheless, oncogenic and toxic effects of MND have to be taken into consideration. OBJECT The aim of this study was to investigate and analyze the incidence of TV in STD and lower susceptibility of certain TV strains to MND were analyzed. MATERIAL AND METHODS In three-year period (1999-2001 612 patients (244 females and 368 males suspected of STD were examined clinically and microbiologically at the Institute of Dermatovenereology in Belgrade. The patients detected for TV were treated according to CDC protocol. The affected were considered cured if there was no manifest clinical infection, and no TV verified by microbiological test. Results TV was isolated in 216 patients (35.29 % of all subjects. Trichomonas infection was found in 90 (36.88 % out of 244 tested females and in 126 (32.34 % of 368 males. Clinically manifested infection, with extensive urethral and vaginal secretion, was recorded in 161 patients, while the asymptomatic form was found in 55 subjects. This result indicates the predominance of manifested trichomonas infections (75.54 % of cases. The difference of distribution of clinical forms of trichomoniasis, in relation to sex, was not statistically significant (c2=0.854; p>0.05. The patients with verified trichomonas infection were treated by metronidazole according to CDC protocol. The recommended therapeutical scheme consisted of three

  3. A mixed methods evaluation of the maternal-newborn dashboard in Ontario: dashboard attributes, contextual factors, and facilitators and barriers to use: a study protocol.

    Science.gov (United States)

    Dunn, Sandra; Sprague, Ann E; Grimshaw, Jeremy M; Graham, Ian D; Taljaard, Monica; Fell, Deshayne; Peterson, Wendy E; Darling, Elizabeth; Harrold, JoAnn; Smith, Graeme N; Reszel, Jessica; Lanes, Andrea; Truskoski, Carolyn; Wilding, Jodi; Weiss, Deborah; Walker, Mark

    2016-05-04

    There are wide variations in maternal-newborn care practices and outcomes across Ontario. To help institutions and care providers learn about their own performance, the Better Outcomes Registry & Network (BORN) Ontario has implemented an audit and feedback system, the Maternal-Newborn Dashboard (MND), for all hospitals providing maternal-newborn care. The dashboard provides (1) near real-time feedback, with site-specific and peer comparison data about six key performance indicators; (2) a visual display of evidence-practice gaps related to the indicators; and (3) benchmarks to provide direction for practice change. This study aims to evaluate the effects of the dashboard, dashboard attributes, contextual factors, and facilitation/support needs that influence the use of this audit and feedback system to improve performance. The objectives of this study are to (1) evaluate the effect of implementing the dashboard across Ontario; (2) explore factors that potentially explain differences in the use of the MND among hospitals; (3) measure factors potentially associated with differential effectiveness of the MND; and (4) identify factors that predict differences in hospital performance. A mixed methods design includes (1) an interrupted time series analysis to evaluate the effect of the intervention on six indicators, (2) key informant interviews with a purposeful sample of directors/managers from up to 20 maternal-newborn care hospitals to explore factors that influence the use of the dashboard, (3) a provincial survey of obstetrical directors/managers from all maternal-newborn hospitals in the province to measure factors that influence the use of the dashboard, and (4) a multivariable generalized linear mixed effects regression analysis of the indicators at each hospital to quantitatively evaluate the change in practice following implementation of the dashboard and to identify factors most predictive of use. Study results will provide essential data to develop knowledge

  4. Influence of extractable soil manganese on oxidation capacity of different soils in Korea

    Science.gov (United States)

    Chon, Chul-Min; Kim, Jae Gon; Lee, Gyoo Ho; Kim, Tack Hyun

    2008-08-01

    We examined the relationship between soil oxidation capacity and extractable soil manganese, iron oxides, and other soil properties. The Korean soils examined in this study exhibited low to medium Cr oxidation capacities, oxidizing 0.00-0.47 mmol/kg, except for TG-4 soils, which had the highest capacity for oxidizing added Cr(III) [>1.01 mmol/kg of oxidized Cr(VI)]. TG and US soils, with high Mn contents, had relatively high oxidation capacities. The Mn amounts extracted by dithionite-citrate-bicarbonate (DCB) (Mnd), NH2OH·HCl (Mnh), and hydroquinone (Mnr) were generally very similar, except for the YS1 soils, and were well correlated. Only small proportions of either total Mn or DCB-extractable Mn were extracted by NH2OH·HCl and hydroquinone in the YS1 soils, suggesting inclusion of NH2OH·HCl and hydroquinone-resistant Mn oxides, because these extractants are weaker reductants than DCB. No Cr oxidation test results were closely related to total Mn concentrations, but Mnd, Mnh, and Mnr showed a relatively high correlation with the Cr tests ( r = 0.655-0.851; P Mnh were better correlated with the Cr oxidation tests than was the Mnr concentration, suggesting that the oxidation capacity of our soil samples can be better explained by Mnd and Mnh than by Mnr. The first component in principal components analysis indicated that extractable soil Mn was a main factor controlling net Cr oxidation in the soils. Total soil Mn, Fe oxides, and the clay fraction are crucial for predicting the mobility of pollutants and heavy metals in soils. The second principal component indicated that the presence of Fe oxides in soils had a significant relationship with the clay fraction and total Mn oxide, and was also related to heavy-metal concentrations (Zn, Cd, and Cu, but not Pb).

  5. Pedigree with frontotemporal lobar degeneration – motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9

    Directory of Open Access Journals (Sweden)

    Loy Clement T

    2008-08-01

    Full Text Available Abstract Background Frontotemporal lobar degeneration (FTLD represents a clinically, pathologically and genetically heterogenous neurodegenerative disorder, often complicated by neurological signs such as motor neuron-related limb weakness, spasticity and paralysis, parkinsonism and gait disturbances. Linkage to chromosome 9p had been reported for pedigrees with the neurodegenerative disorder, frontotemporal lobar degeneration (FTLD and motor neuron disease (MND. The objective in this study is to identify the genetic locus in a multi-generational Australian family with FTLD-MND. Methods Clinical review and standard neuropathological analysis of brain sections from affected pedigree members. Genome-wide scan using microsatellite markers and single nucleotide polymorphism fine mapping. Examination of candidate genes by direct DNA sequencing. Results Neuropathological examination revealed cytoplasmic deposition of the TDP-43 protein in three affected individuals. Moreover, we identify a family member with clinical Alzheimer's disease, and FTLD-Ubiquitin neuropathology. Genetic linkage and haplotype analyses, defined a critical region between markers D9S169 and D9S1845 on chromosome 9p21. Screening of all candidate genes within this region did not reveal any novel genetic alterations that co-segregate with disease haplotype, suggesting that one individual carrying a meiotic recombination may represent a phenocopy. Re-analysis of linkage data using the new affection status revealed a maximal two-point LOD score of 3.24 and a multipoint LOD score of 3.41 at marker D9S1817. This provides the highest reported LOD scores from a single FTLD-MND pedigree. Conclusion Our reported increase in the minimal disease region should inform other researchers that the chromosome 9 locus may be more telomeric than predicted by published recombination boundaries. Moreover, the existence of a family member with clinical Alzheimer's disease, and who shares the disease

  6. Clinical profile of motor neuron disease patients with lower urinary tract symptoms and neurogenic bladder.

    Science.gov (United States)

    Vázquez-Costa, Juan Francisco; Arlandis, Salvador; Hervas, David; Martínez-Cuenca, Esther; Cardona, Fernando; Pérez-Tur, Jordi; Broseta, Enrique; Sevilla, Teresa

    2017-07-15

    Lower urinary tract symptoms (LUTS) are frequent in motor neuron disease (MND) patients, but clinical factors related to them are unknown. We describe differences in LUTS among MND phenotypes and their relationship with other clinical characteristics, including prognosis. For this study, we collected clinical data of a previously published cohort of patients diagnosed with classical amyotrophic lateral sclerosis (cALS), progressive muscular atrophy (PMA) or primary lateral sclerosis (PLS) with and without LUTS. Familial history was recorded and the C9ORF72 expansion was analysed in the entire cohort. Patients were followed-up for survival until August 2016. Fifty-five ALS patients (37 cALS, 10 PMA and 8 PLS) were recruited. Twenty-four reported LUTS and neurogenic bladder (NB) could be demonstrated in nine of them. LUTS were not influenced by age, phenotype, disability, cognitive or behavioural impairment, or disease progression, but female sex appeared to be a protective factor (OR=0.39, p=0.06). Neither family history nor the C9ORF72 expansion was linked to LUTS or NB. In the multivariate analysis, patients reporting LUTS early in the disease course tended to show poorer survival. In this study, LUTS appear to be more frequent in male MND patients, but are not related to age, clinical or genetic characteristics. When reported early, LUTS could be a sign of rapid disease spread and poor prognosis. Further prospective longitudinal and neuroimaging studies are warranted to confirm this hypothesis. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Age-Related Uptake of Heavy Metals in Human Spinal Interneurons.

    Directory of Open Access Journals (Sweden)

    Roger Pamphlett

    Full Text Available Toxic heavy metals have been implicated in the loss of spinal motoneurons in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND. Motoneuron loss in the spinal anterior horn is severe in ALS/MND at the time of death, making this tissue unsuitable for examination. We therefore examined spinal cords of people without muscle weakness to look for any presence of heavy metals that could make these neurons susceptible to damage. Spinal cord samples from 50 individuals aged 1-95 y who had no clinical or histopathological evidence of spinal motoneuron loss were studied. Seven μm formalin-fixed paraffin-embedded sections were stained for heavy metals with silver nitrate autometallography (AMGHM which detects intracellular mercury, silver or bismuth. Neurons in the spinal cord were classified as interneurons or α-motoneurons based on their site and cell body diameter. Spinal interneurons containing heavy metals were present in 8 of 24 people (33% aged 61-95 y, but not at younger ages. These AMGHM interneurons were most numerous in the lumbar spinal cord, with moderate numbers in the caudal cervical cord, few in the rostral cervical cord, and almost none in the thoracic cord. All people with AMGHM interneurons had occasional AMGHM staining in α-motoneurons as well. In one man AMGHM staining was present in addition in dorsomedial nucleus and sensory neurons. In conclusion, heavy metals are present in many spinal interneurons, and in a few α-motoneurons, in a large proportion of older people. Damage to inhibitory interneurons from toxic metals in later life could result in excitotoxic injury to motoneurons and may underlie motoneuron injury or loss in conditions such as ALS/MND, multiple sclerosis, sarcopenia and calf fasciculations.

  8. Studies on motor neuron disease with cranial magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Mitsui, Yoshiyuki; Takahashi, Mitsuo; Nakamura, Yusaku; Kitaguchi, Masataka; Yagi, Yuji (Kinki Univ., Osaka (Japan). School of Medicine)

    1992-05-01

    The present study was performed to examine the pyramidal tracts of the brain in both 51 normal subjects (21 male and 30 female subjects; mean age of 43.5[+-]16.1 years) and 12 patients with motor neuron disease (6 male and 6 female patients; mean age of 57.4[+-]7.9 years), using the magnetic resonance imaging (MRI). The 12 patients with motor neuron disease (MND) comprised 7 suffering from spinal progressive muscular atrophy (SPMA) and 5 from amyotrophic lateral sclerosis (ALS). The MRI used in this study was of both short spin echo and long spin echo sequence. Of the 52 normal subjects, 24 of them (47%) had the T2 prolonged small areas (high signal intensity areas) at the posterior limb of internal capsule. These findings were not found in the normal subjects over fifty years old. No similar finding was detected in the pyramidal tracts except the posterior limb of internal capsule. On the other hand, 8 patients with MND (67%) proved to have the high signal intensity areas in the pyramidal tracts. Moreover, these high intensity areas were extended from the crus cerebri to corona radiata in 7 patients (58%). In all patients with ALS, these areas were extended in whole areas of the pyramidal tracts, and the similar findings were also found in two patients with SPMA. These findings were demonstrated to be more extensive than those in the normal subjects. The results thus obtained warrant us to conclude that cranial MRI is useful to detect the degeneration of the pyramidal tracts of MND patients. (author).

  9. Studies on motor neuron disease with cranial magnetic resonance imaging

    International Nuclear Information System (INIS)

    Mitsui, Yoshiyuki; Takahashi, Mitsuo; Nakamura, Yusaku; Kitaguchi, Masataka; Yagi, Yuji

    1992-01-01

    The present study was performed to examine the pyramidal tracts of the brain in both 51 normal subjects (21 male and 30 female subjects; mean age of 43.5±16.1 years) and 12 patients with motor neuron disease (6 male and 6 female patients; mean age of 57.4±7.9 years), using the magnetic resonance imaging (MRI). The 12 patients with motor neuron disease (MND) comprised 7 suffering from spinal progressive muscular atrophy (SPMA) and 5 from amyotrophic lateral sclerosis (ALS). The MRI used in this study was of both short spin echo and long spin echo sequence. Of the 52 normal subjects, 24 of them (47%) had the T2 prolonged small areas (high signal intensity areas) at the posterior limb of internal capsule. These findings were not found in the normal subjects over fifty years old. No similar finding was detected in the pyramidal tracts except the posterior limb of internal capsule. On the other hand, 8 patients with MND (67%) proved to have the high signal intensity areas in the pyramidal tracts. Moreover, these high intensity areas were extended from the crus cerebri to corona radiata in 7 patients (58%). In all patients with ALS, these areas were extended in whole areas of the pyramidal tracts, and the similar findings were also found in two patients with SPMA. These findings were demonstrated to be more extensive than those in the normal subjects. The results thus obtained warrant us to conclude that cranial MRI is useful to detect the degeneration of the pyramidal tracts of MND patients. (author)

  10. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

    Science.gov (United States)

    Baldauf, Hanna-Mari; Stegmann, Lena; Schwarz, Sarah-Marie; Ambiel, Ina; Trotard, Maud; Martin, Margarethe; Burggraf, Manja; Lenzi, Gina M; Lejk, Helena; Pan, Xiaoyu; Fregoso, Oliver I; Lim, Efrem S; Abraham, Libin; Nguyen, Laura A; Rutsch, Frank; König, Renate; Kim, Baek; Emerman, Michael; Fackler, Oliver T; Keppler, Oliver T

    2017-03-07

    Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT. The accessory lentiviral protein X (Vpx) proteins from the major simian immunodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2) lineage packaged into virions target SAMHD1 for proteasomal degradation, increase intracellular dNTP pools, and facilitate HIV cDNA synthesis. We find that virion-packaged Vpx proteins from a second SIV lineage, SIV of red-capped mangabeys or mandrills (SIVrcm/mnd-2), increased HIV infection in resting CD4 T cells, but not in macrophages, and, unexpectedly, acted in the absence of SAMHD1 degradation, dNTP pool elevation, or changes in SAMHD1 phosphorylation. Vpx rcm/mnd-2 virion incorporation resulted in a dramatic increase of HIV-1 RT intermediates and viral cDNA in infected resting CD4 T cells. These analyses also revealed a barrier limiting HIV-1 infection of resting CD4 T cells at the level of nuclear import. Single amino acid changes in the SAMHD1-degrading Vpx mac239 allowed it to enhance early postentry steps in a Vpx rcm/mnd-2-like fashion. Moreover, Vpx enhanced HIV-1 infection of SAMHD1-deficient resting CD4 T cells of a patient with Aicardi-Goutières syndrome. These results indicate that Vpx, in addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level of RT that acts independently of dNTP concentrations and is specific to resting CD4 T cells.

  11. CSF glial markers correlate with survival in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Süssmuth, S D; Sperfeld, A D; Hinz, A; Brettschneider, J; Endruhn, S; Ludolph, A C; Tumani, H

    2010-03-23

    In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), CSF biomarkers are increasingly studied to evaluate their relevance for differential diagnosis, disease progression, and understanding of pathophysiologic processes. To identify a biomarker profile of neuronal and glial CSF proteins to discriminate ALS from other motor neuron diseases (MND) and to assess whether baseline levels of CSF measures in ALS are associated with the course of the disease. A total of 122 consecutive subjects with MND were included in this cross-sectional study (ALS, n = 75; lower motor neuron syndrome, n = 39; upper motor neuron diseases, n = 8). Clinical follow-up included 76 patients. We determined baseline levels of protein tau and astroglial S100beta in CSF and microglial sCD14 in CSF and serum in relation to diagnosis, duration of disease, and survival. CSF tau was significantly elevated in ALS and upper motor neuron diseases as compared to lower motor neuron diseases and controls. CSF S100beta levels were significantly lower in lower motor neuron diseases as compared to other MND. CSF concentrations of S100beta and sCD14 correlated with the survival time in patients with ALS. In motor neuron diseases, CSF tau elevation indicates the degeneration of upper motor neurons, while S100 beta and sCD14 may indicate the activation of CNS glial cells. Because S100beta and sCD14 concentrations correlate with survival in amyotrophic lateral sclerosis (ALS), we suppose that the combination of both markers may be useful to obtain prognostic information in patients with ALS.

  12. Multimodal structural MRI in the diagnosis of motor neuron diseases

    Directory of Open Access Journals (Sweden)

    Pilar M. Ferraro

    2017-01-01

    Full Text Available This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS, 44 patients with predominantly upper motor neuron disease (PUMN, 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis. In the training set, precentral cortical thickness showed 0.86 and 0.89 accuracy in differentiating ALS and PUMN patients from controls, while DT MRI distinguished the two groups from controls with 0.78 and 0.92 accuracy. In ALS vs controls, the combination of cortical thickness and DT MRI metrics (combined model improved the classification pattern (0.91 accuracy. In the validation cohort, the best accuracy was reached by DT MRI (0.87 and 0.95 accuracy in ALS and PUMN vs mimic disorders. The combined model distinguished ALS and PUMN patients from mimic syndromes with 0.87 and 0.94 accuracy. A multimodal MRI approach that incorporates motor cortical and white matter alterations yields statistically significant improvement in accuracy over using each modality separately in the individual MND patient classification. DT MRI represents the most powerful tool to distinguish MND from mimic disorders.

  13. Mood and quality of life among people with progressive neurological illnesses

    OpenAIRE

    Marita P. McCabe; Lucy Firth; Elodie O´Connor

    2009-01-01

    El presente estudio ex post facto fue diseñado para examinar el estado de ánimo y la calidad de vida (QQL) entre 423 personas con enfermedad neurológica progresiva. En particular, se ha investigado la relación entre las variables de la enfermedad y el estado de ánimo y calidad de vida de 120 personas con enfermedad de la neuronales motoras (MND), 48 con enfermedad de Huntington (HD), 143 con Parkinson y 112 con esclerosis múltiple (MS). Los resultados demostraron que las personas con HD co...

  14. The challenges of dysphagia in treating motor neurone disease.

    Science.gov (United States)

    Vesey, Siobhan

    2017-07-01

    Motor neurone disease (MND) is a relatively rare degenerative disorder. Its impacts are manifested in progressive loss of motor function and often accompanied by wider non-motor changes. Swallowing and speech abilities are frequently severely impaired. Effective management of dysphagia (swallowing difficulty) symptoms and nutritional care requires a holistic multidisciplinary approach. Care must be patient focused, facilitate patient decision making, and support planning towards end of life care. This article discusses the challenges of providing effective nutritional care to people living with motor neurone disease who have dysphagia.

  15. Defense at Low Force Levels: The Effect of Force to Space Ratios on Conventional Combat Dynamics

    Science.gov (United States)

    1991-08-01

    attempted falsification , or to answer the kinds of detailed questions that emerged once the policy community discovered the issue. How strong is the...Pat I," Milk =x.eview. September 1985, pp. 35-36.3 12CJ. Dick, ’Soviet Operational Art, Part I: The Fruits of Experience," IDR No. 7,1988, pp. 759-760...2,1989, p. 141. 3 14 DaiM M. Glantz, "Operational Art mnd Tactcs," Milk = Review, December 1988, pp. 37-38. 151bid, p. 39. 3 16 C.N. Donnelly, "The

  16. Multivokselska magnetno-rezonantna spektroskopija mozga kod HIV+ pacijenata

    OpenAIRE

    Boban, Jasmina

    2016-01-01

    UVOD: Neurokognitivni poremećaj udružen sa HIVinfekcijom (HIV associated neurocognitive disorder- HAND) javlja se u oko polovine pacijenata sa HIV-om. HAND obuhvata spektar neuroloških poremećaja koji variraju od asimptomatskog neurokognitivnog poremećaja(ANI), preko blagog kognitivnog oštećenja, koje se naziva blagi kognitivni poremećaj (MND) do demencije udružene sa HIV-om (HAD). U evaluaciji i dijagnostici ovog poremećaja koriste se razne laboratorijske, kliničke i metode imi...

  17. Outcomes of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease: a systematic review.

    Science.gov (United States)

    Morris, Meg E; Perry, Alison; Bilney, Belinda; Curran, Andrea; Dodd, Karen; Wittwer, Joanne E; Dalton, Gregory W

    2006-09-01

    This article describes a systematic review and critical evaluation of the international literature on the effects of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease (PwMND). The results were interpreted using the framework of the International Classification of Functioning, Disability and Health. This enabled us to summarize therapy outcomes at the level of body structure and function, activity limitations, participation restrictions, and quality of life. Databases searched included MEDLINE, PUBMED, CINAHL, PSYCInfo, Data base of Abstracts of Reviews of Effectiveness (DARE), The Physiotherapy Evidence data base (PEDro), Evidence Based Medicine Reviews (EMBASE), the Cochrane database of systematic reviews, and the Cochrane Controlled Trials Register. Evidence was graded according to the Harbour and Miller classification. Most of the evidence was found to be at the level of "clinical opinion" rather than of controlled clinical trials. Several nonrandomized small group and "observational studies" provided low-level evidence to support physical therapy for improving muscle strength and pulmonary function. There was also some evidence to support the effectiveness of speech pathology interventions for dysarthria. The search identified a small number of studies on occupational therapy for PwMND, which were small, noncontrolled pre-post-designs or clinical reports.

  18. A micromechanical interpretation of the temperature dependence of Beremin model parameters for French RPV steel

    International Nuclear Information System (INIS)

    Mathieu, Jean-Philippe; Inal, Karim; Berveiller, Sophie; Diard, Olivier

    2010-01-01

    Local approach to brittle fracture for low-alloyed steels is discussed in this paper. A bibliographical introduction intends to highlight general trends and consensual points of the topic and evokes debatable aspects. French RPV steel 16MND5 (equ. ASTM A508 Cl.3), is then used as a model material to study the influence of temperature on brittle fracture. A micromechanical modelling of brittle fracture at the elementary volume scale already used in previous work is then recalled. It involves a multiscale modelling of microstructural plasticity which has been tuned on experimental inter-phase and inter-granular stresses heterogeneities measurements. Fracture probability of the elementary volume can then be computed using a randomly attributed defect size distribution based on realistic carbides repartition. This defect distribution is then deterministically correlated to stress heterogeneities simulated within the microstructure using a weakest-link hypothesis on the elementary volume, which results in a deterministic stress to fracture. Repeating the process allows to compute Weibull parameters on the elementary volume. This tool is then used to investigate the physical mechanisms that could explain the already experimentally observed temperature dependence of Beremin's parameter for 16MND5 steel. It is showed that, assuming that the hypothesis made in this work about cleavage micro-mechanisms are correct, effective equivalent surface energy (i.e. surface energy plus plastically dissipated energy when blunting the crack tip) for propagating a crack has to be temperature dependent to explain Beremin's parameters temperature evolution.

  19. [History of hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)].

    Science.gov (United States)

    Takashima, Hiroshi

    2013-01-01

    We established a new disease autosomal dominant hereditary motor and sensory neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, Japan. This disease is characterized by proximal dominant neurogenic atrophy with fasciculations, painful muscle cramp, obvious sensory nerve involvement, areflexia, high incidence of elevated creatine kinase levels, hyperlipidemia and hyperglycemia. (MIM %604484). HMSNP is so called or HMSNO (HMSN OKINAWA type),. These clinical features resembled those of Kennedy-Alter-Sung syndrome. Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required. Therefore, we initially thought to classify HMSNP into a subtype of motor neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or spinal muscular atrophy (SMA). However, the general consensus for MND was no sensory involvement. Therefore, as the disease showed severe sensory involvement, we categorized HMSNP in subtype of HMSN at that time. We also reported the pathology of HMSNP, showing severely decreased anterior horn cells, decreased posterior horn cells, and loss of posterior funiculus in the spinal cord.

  20. New trace element determinations in the fingernails of ALS patients

    Energy Technology Data Exchange (ETDEWEB)

    Van Dalsem, D.J.; Ehmann, W.D. [Univ. of Kentucky, Lexington, KY (United States); Robinson, L. [Oak Ridge National Laboratory, TN (United States)

    1996-12-31

    Amyotrophic lateral sclerosis (ALS) afflicts 2 of every 100,000 people in the United States each year. A well-known example of ALS today is Stephen Hawking. He is a theoretical physicist, the author of A Brief History of Time, and is virtually immobilized by ALS. Diseases that cause progressive paralysis because of motor neuron degeneration in the central nervous system are termed motor neuron disorders (MND). Amyotrophic lateral sclerosis is a common form of MND. Pain-free, progressive muscular weakness is the most common clinical symptom. There is chronic weakness with atrophy of the affected muscles by the time the disease is diagnosed. Atrophy eventually results in wheelchair confinement and then only bed without the ability to speak or swallow. Death often occurs as a result of respiratory problems. Unlike other neurodegenerative diseases, in ALS the patient`s bladder and bowel control, eye movement, and mental faculties are preserved. The question today is whether or not certain trace elements are involved in the etiology or pathogenesis of ALS. A collaborative study was undertaken by the University of Kentucky and Oak Ridge National Laboratory (ORNL) using neutron activation analysis (NAA) to study trace element concentrations in ALS patients fingernails to determine if there existed statistically significant imbalances.

  1. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases

    Directory of Open Access Journals (Sweden)

    Holmerová Iva

    2011-05-01

    Full Text Available Abstract Background Frontotemporal lobar degeneration with ubiquitin and TDP-43 positive neuronal inclusions represents a novel entity (FTLD-TDP that may be associated with motor neuron disease (FTLD-MND; involvement of extrapyramidal and other systems has also been reported. Case presentation We present three cases with similar clinical symptoms, including Parkinsonism, supranuclear gaze palsy, visuospatial impairment and a behavioral variant of frontotemporal dementia, associated with either clinically possible or definite MND. Neuropathological examination revealed hallmarks of FTLD-TDP with major involvement of subcortical and, in particular, mesencephalic structures. These cases differed in onset and progression of clinical manifestations as well as distribution of histopathological changes in the brain and spinal cord. Two cases were sporadic, whereas the third case had a pathological variation in the progranulin gene 102 delC. Conclusions Association of a "progressive supranuclear palsy-like" syndrome with marked visuospatial impairment, motor neuron disease and early behavioral disturbances may represent a clinically distinct phenotype of FTLD-TDP. Our observations further support the concept that TDP-43 proteinopathies represent a spectrum of disorders, where preferential localization of pathogenetic inclusions and neuronal cell loss defines clinical phenotypes ranging from frontotemporal dementia with or without motor neuron disease, to corticobasal syndrome and to a progressive supranuclear palsy-like syndrome.

  2. Survival in the pre-senile dementia frontotemporal lobar degeneration with TDP-43 proteinopathy: effects of genetic, demographic and neuropathological variables

    Directory of Open Access Journals (Sweden)

    Richard A. Armstrong

    2016-06-01

    Full Text Available Factors associated with survival were studied in 84 neuropathologically documented cases of the pre-senile dementia frontotemporal dementia lobar degeneration (FTLD with transactive response (TAR DNA-binding protein of 43 kDa (TDP-43 proteinopathy (FTLD-TDP. Kaplan-Meier survival analysis estimated mean survival as 7.9 years (range: 1-19 years, SD = 4.64. Familial and sporadic cases exhibited similar survival, including progranulin (GRN gene mutation cases. No significant differences in survival were associated with sex, disease onset, Braak disease stage, or disease subtype, but higher survival was associated with lower post-mortem brain weight. Survival was significantly reduced in cases with associated motor neuron disease (FTLD-MND but increased with Alzheimer’s disease (AD or hippocampal sclerosis (HS co-morbidity. Cox regression analysis suggested that reduced survival was associated with increased densities of neuronal cytoplasmic inclusions (NCI while increased survival was associated with greater densities of enlarged neurons (EN in the frontal and temporal lobes. The data suggest that: (1 survival in FTLD-TDP is more prolonged than typical in pre-senile dementia but shorter than some clinical subtypes such as the semantic variant of primary progressive aphasia (svPPA, (2 MND co-morbidity predicts poor survival, and (3 NCI may develop early and EN later in the disease. The data have implications for both neuropathological characterization and subtyping of FTLD-TDP.

  3. Structure and DNA-binding of meiosis-specific protein Hop2

    Science.gov (United States)

    Zhou, Donghua; Moktan, Hem; Pezza, Roberto

    2014-03-01

    Here we report structure elucidation of the DNA binding domain of homologous pairing protein 2 (Hop2), which is important to gene diversity when sperms and eggs are produced. Together with another protein Mnd1, Hop2 enhances the strand invasion activity of recombinase Dmc1 by over 30 times, facilitating proper synapsis of homologous chromosomes. However, the structural and biochemical bases for the function of Hop2 and Mnd1 have not been well understood. As a first step toward such understanding, we recently solved the structure for the N-terminus of Hop2 (1-84) using solution NMR. This fragment shows a typical winged-head conformation with recognized DNA binding activity. DNA interacting sites were then investigated by chemical shift perturbations in a titration experiment. Information of these sites was used to guide protein-DNA docking with MD simulation, revealing that helix 3 is stably lodged in the DNA major groove and that wing 1 (connecting strands 2 and 3) transiently comes in contact with the minor groove in nanosecond time scale. Mutagenesis analysis further confirmed the DNA binding sites in this fragment of the protein.

  4. Host feeding pattern of Japanese encephalitis virus vector mosquitoes (Diptera: Culicidae) from Kuttanadu, Kerala, India.

    Science.gov (United States)

    Philip Samuel, P; Arunachalam, N; Hiriyan, J; Tyagi, B K

    2008-09-01

    Identification of blood meals of vector mosquitoes is an important tool in the epidemiological investigations of vector-borne diseases. The blood meals of three mosquito species involved in the transmission of Japanese encephalitis virus (JEV) from the Kuttanadu area, Kerala, were determined using the agarose gel diffusion technique. A total of 4959 blood smears belonging to Culex (Culex) tritaeniorhynchus Giles (3273), Cx. (Culex) gelidus Theobald (64), Mansonia (Mnd.) indiana Edwards (735) ,and Ma. (Mnd.) uniformis (Theobald) (887) were tested. Cx. tritaeniorhynchus had predominantly fed on bovids (46.4%), and a good proportion (29%) had fed on more than one host. Cx. tritaeniorhynchus was highly zoophagic, and human feeding accounted for only 1.5% of those individuals successfully tested. Cx. gelidus showed bovid feeding at 36% and pig feeding at 12.5%. The test results showed 42.3% Ma. indiana and 12.2% Ma. uniformis had fed on humans. Multiple feeding was observed in Ma. indiana and Ma. uniformis, and most of the double feedings were from bovids and ovids (7.9 and 20.1%, respectively). Pig feeding accounted for 4.8% of the feedings by Cx. tritaeniorhynchus, 5.3% of Ma. indiana, and 6.4% of Ma. uniformis. This study is significant because of the role played by these mosquitoes in the transmission of JEV in the Kuttanadu area of Kerala, India.

  5. Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

    Institute of Scientific and Technical Information of China (English)

    Manoj Kumar Jaiswal

    2017-01-01

    Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenera-tive diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord.The clinical phenotype is characterized by loss of motor neurons (MNs), mus-cular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3–5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro"disease in dish"and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

  6. Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.

    Science.gov (United States)

    Jaiswal, Manoj Kumar

    2017-05-01

    Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons (MNs), muscular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3-5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro " disease in dish " and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

  7. Design and implementation of a hybrid MPI-CUDA model for the Smith-Waterman algorithm.

    Science.gov (United States)

    Khaled, Heba; Faheem, Hossam El Deen Mostafa; El Gohary, Rania

    2015-01-01

    This paper provides a novel hybrid model for solving the multiple pair-wise sequence alignment problem combining message passing interface and CUDA, the parallel computing platform and programming model invented by NVIDIA. The proposed model targets homogeneous cluster nodes equipped with similar Graphical Processing Unit (GPU) cards. The model consists of the Master Node Dispatcher (MND) and the Worker GPU Nodes (WGN). The MND distributes the workload among the cluster working nodes and then aggregates the results. The WGN performs the multiple pair-wise sequence alignments using the Smith-Waterman algorithm. We also propose a modified implementation to the Smith-Waterman algorithm based on computing the alignment matrices row-wise. The experimental results demonstrate a considerable reduction in the running time by increasing the number of the working GPU nodes. The proposed model achieved a performance of about 12 Giga cell updates per second when we tested against the SWISS-PROT protein knowledge base running on four nodes.

  8. Systematic review of non-invasive positive pressure ventilation for chronic respiratory failure.

    Science.gov (United States)

    Hannan, Liam M; Dominelli, Giulio S; Chen, Yi-Wen; Darlene Reid, W; Road, Jeremy

    2014-02-01

    This systematic review examined the effect of non-invasive positive pressure ventilation (NIPPV) on patient reported outcomes (PROs) and survival for individuals with or at risk of chronic respiratory failure (CRF). Randomised controlled trials (RCTs) and prospective non-randomised studies in those treated with NIPPV for CRF were identified from electronic databases, reference lists and grey literature. Diagnostic groups included in the review were amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), Duchenne muscular dystrophy (DMD), restrictive thoracic disease (RTD) and obesity hypoventilation syndrome (OHS). Eighteen studies were included and overall study quality was weak. Those with ALS/MND had improved somnolence and fatigue as well as prolonged survival with NIPPV. For OHS, improvements in somnolence and fatigue, dyspnoea and sleep quality were demonstrated, while for RTD, measures of dyspnoea, sleep quality, physical function and health, mental and emotional health and social function improved. There was insufficient evidence to form conclusions regarding the effect of NIPPV for those with DMD. This review has demonstrated that NIPPV influences PROs differently depending on the underlying cause of CRF. These findings may provide assistance to patients and clinicians to determine the relative costs and benefits of NIPPV therapy and also highlight areas in need of further research. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Predictors of activity and participation across neurodegenerative conditions: a comparison of people with motor neurone disease, multiple sclerosis and Parkinson's disease.

    Science.gov (United States)

    Morley, David; Dummett, Sarah; Kelly, Laura; Fitzpatrick, Ray; Jenkinson, Crispin

    2018-02-17

    Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predictors of activity and participation in people with motor neurone disease (MND), people with multiple sclerosis (MS) and people with Parkinson's Disease (PD). The Oxford Participation and Activities Questionnaire (Ox-PAQ) and Medical Outcomes Study 36-Item Short Form Survey (MOS SF-36) were administered by postal survey to 386 people with a confirmed diagnosis of MND, MS or PD. Data analyses focused on stepwise regression analyses in order to identify predictors of activity and participation in the three conditions assessed. Three hundred and thirty four participants completed the survey, a response rate of 86.5%. Regression analyses identified multiple predictors of activity and participation dependent on Ox-PAQ domain and disease group, the most prominent being social and physical functioning as measured by the MOS SF-36. Results indicate that the physical and social consequences of neurological illness are of greatest relevance to people experiencing the conditions assessed. Whilst the largely inevitable physical implications of disease take hold, emphasis should be placed on the avoidance of social withdrawal and isolation, and the maintenance of social engagement should become a significant priority.

  10. Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant.

    Science.gov (United States)

    Melchionda, Laura; Fang, Mingyan; Wang, Hairong; Fugnanesi, Valeria; Morbin, Michela; Liu, Xuanzhu; Li, Wenyan; Ceccherini, Isabella; Farina, Laura; Savoiardo, Mario; D'Adamo, Pio; Zhang, Jianguo; Costa, Alfredo; Ravaglia, Sabrina; Ghezzi, Daniele; Zeviani, Massimo

    2013-05-01

    We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexander's disease (AOAD), suggesting different expression of the same, genetically determined, condition. Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells. Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated filamentous cytoskeletal meshwork of astrocytoma cells. To shed light on the different clinical features in the two patients, we sought for variants in other genes. The male patient had a mutation, absent in his half-sister, in X-linked histone deacetylase 6, a candidate MND susceptibility gene. Exome-NGS is an unbiased approach that not only helps identify new disease genes, but may also contribute to elucidate phenotypic expression.

  11. A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.

    Science.gov (United States)

    Mitne-Neto, M; Ramos, C R R; Pimenta, D C; Luz, J S; Nishimura, A L; Gonzales, F A; Oliveira, C C; Zatz, M

    2007-09-01

    Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset Motor Neuron Disease (MND), characterized by motor neurons death in the cortex, brainstem and spinal cord. Ten loci linked to Familial ALS have been mapped. ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-B/C (VAP-B/C). VAP-B belongs to a highly conserved family of proteins implicated in Endoplasmic Reticulum-Golgi and intra-Golgi transport and microtubules stabilization. Previous studies demonstrated that the P56S mutation disrupts the subcellular localization of VAP-B and that this position would be essential for Unfolded Protein Response (UPR) induced by VAP-B. In the present work we expressed and purified recombinant wild-type and P56S mutant VAP-B-MSP domain for the analysis of its interactions with other cellular proteins. Our findings suggest that the P56S mutation may lead to a less stable interaction of this endoplasmic reticulum protein with at least two other proteins: tubulin and GAPDH. These two proteins have been previously related to other forms of neurodegenerative diseases and are potential key points to understand ALS8 pathogenesis and other forms of MND. Understanding the role of these protein interactions may help the treatment of this devastating disease in the future.

  12. Amyotrophic lateral sclerosis-like presentation in a HIV-positive patient.

    Science.gov (United States)

    Anand, Kuljeet Singh; Wadhwa, Ankur; Garg, Jyoti; Mahajan, Rakesh Kumar

    2014-01-01

    There has been several reports of an MND like syndrome in HIV-1 infection, however the data is still sparse. Furthermore, HIV-associated amyotrophic lateral sclerosis (ALS) syndrome differs from the classical ALS in some key aspects.. A 44-year-old male presented with a history of insidious onset and gradually progressive asymmetric weakness of lower limbs. He also complained of thinning in both legs, the left leg more than the right since 1 year along with spontaneous twitching of muscles in both the thighs. On neurological examination, the assessment of higher mental functions was normal. There were no cranial nerve deficits. Motor power was grade 5/5 (Medical Research Council scale) in both the upper limbs and 4+ at hips and knees bilaterally, 5 at right ankle, and 4+ at left ankle. All the deep tendon reflexes were brisk with extensor planter responses. There were no cerebellar signs or sensory deficits. HIV-1 was reactive in enzyme-linked immunosorbent assay. Electrophysiological studies were conducted per the MND protocol.None of the nerves studied showed an abnormal drop in compound muscle action potential amplitude with proximal stimulation. There was evidence of diffuse spontaneous activity, which manifests as fibrillation and fasciculation potentials in most muscles tested . Overall there seems to be sufficient evidence to implicate HIV as a potential cause of an ALS-like disorder, but one must also consider the possibility of coincidental HIV infection in patients who have sporadic ALS. © The Author(s) 2014.

  13. iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development

    Directory of Open Access Journals (Sweden)

    Irene Faravelli

    2014-10-01

    Full Text Available Motor neuron diseases (MNDs are neuromuscular disorders affecting rather exclusively upper motor neurons (UMNs and/or lower motor neurons (LMNs. The clinical phenotype is characterized by muscular weakness and atrophy leading to paralysis and almost invariably death due to respiratory failure. Adult MNDs include sporadic and familial amyotrophic lateral sclerosis (sALS-fALS, while the most common infantile MND is represented by spinal muscular atrophy (SMA. No effective treatment is ccurrently available for MNDs, as for the vast majority of neurodegenerative disorders, and cures are limited to supportive care and symptom relief. The lack of a deep understanding of MND pathogenesis accounts for the difficulties in finding a cure, together with the scarcity of reliable in vitro models. Recent progresses in stem cell field, in particular in the generation of induced Pluripotent Stem Cells (iPSCs has made possible for the first time obtaining substantial amounts of human cells to recapitulate in vitro some of the key pathogenetic processes underlying MNDs. In the present review, recently published studies involving the use of iPSCs to unravel aspects of ALS and SMA pathogenesis are discussed with an overview of their implications in the process of finding a cure for these still orphan disorders.

  14. Kasvatusteaduslike tööde konkursi tulemused / Ulve Kala

    Index Scriptorium Estoniae

    Kala, Ulve, 1947-

    2002-01-01

    Eesti keeles publitseeritud teadustöö preemia anti Aleksander Elangole, Inger Kraavile ja Kristi Kõivule, diplom Ühiskondlikule Pedagoogika Uurimise Instituudile, Viivi Ekstale, Inger Kraavile, Inge Undile, Viivi Maansole. Võõrkeeles publitseeritud teadustöö preemia monograafiale "Integration als Problem in der Erziehungswissenschaft" (koostaja Airi Liimets, autorid Airi Liimets, Saila Anttonen, Gunnar Bergendal, Gerd-Bodo Reinert von Carlsburg, Helmut Wehr, Tiiu Kuurme, Pauli Siljander, Jüri Kruusvall, Sirje Priimägi, Ene-Silvia Sarv, Kristi Kõiv, Meri-Liis Laherand, Jaan Mikk, Hannele Niemi, Marika Veisson, Irina Würscher, Susanne Jena, Tiina Aunin, Reet Liimets, Heli Mattisen, Aivo Saar, Maie Vikat), diplom Aino Saarele ja Katrin Niglasele. Didaktilis-rakenduslike tööde preemia Eda Heinlale, Estelle Laanele ja Kalle Laanele, Tiiu Kadajasele. Populaarteadusliku töö preemia Maie Tuulikule, diplom Kristi Kõivule. H. Liimetsa nim magistritööde preemia Rain Mikserile, Margus Pedastele, Ülle Rannutile, Inger Kraavile, Tago Sarapuule, Martin Ehalale

  15. Capecitabine-induced cardiotoxicity: more evidence or clinical approaches to protect the patients' heart?

    Directory of Open Access Journals (Sweden)

    Fontanella C

    2014-09-01

    Full Text Available Caterina Fontanella,1 Marianna Aita,1 Marika Cinausero,1 Giuseppe Aprile,1 Maria Grazia Baldin,2 Veronica Dusi,3 Chiara Lestuzzi,4 Gianpiero Fasola,1 Fabio Puglisi1,5 1Department of Oncology, University Hospital of Udine, Udine, Italy; 2Department of Cardiology, Palmanova General Hospital, Palmanova, Italy; 3Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 4Department of Cardiology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy; 5Department of Medical and Biological Sciences, University of Udine, Udine, Italy Abstract: Fluoropyrimidines, such as capecitabine and 5-fluorouracil, may cause cardiac toxicity. In recent years, the incidence of this side effect has increased and it is expected to further rise due to the population aging and the disproportionate incidence of breast and gastrointestinal cancers in older individuals. The spectrum of cardiac manifestations includes different signs and symptoms and the diagnosis may be difficult. Here, we report the case of a 43-year-old woman with advanced breast cancer who was rechallenged with a capecitabine-based regimen after experiencing a cardiac adverse event during the first fluoropyrimidine exposure. This real-practice case serves as a springboard for discussion about the current evidence on differential diagnosis of capecitabine-related cardiac toxicity, its risk factors, and the underpinning mechanisms of early onset. Moreover, we discussed whether a rechallenge with fluoropyrimidines could be safe in patients who had experienced a previous cardiac adverse event. Keywords: risk factors, clinical manifestation, rechallenge

  16. Transition from the adiabatic to the sudden limit in core-electron photoemission

    Science.gov (United States)

    Hedin, Lars; Michiels, John; Inglesfield, John

    1998-12-01

    Experimental results for core-electron photoemission Jk(ω) are often compared with the one-electron spectral function Ac(ɛk-ω), where ω is the photon energy, ɛk is the photoelectron energy, and the optical transition matrix elements are taken as constant. Since Jk(ω) is nonzero only for ɛk>0, we must actually compare it with Ac(ɛk-ω)θ(ɛk). For metals Ac(ω) is known to have a quasiparticle (QP) peak with an asymmetric power-law [theories of Mahan, Nozières, de Dominicis, Langreth, and others (MND)] singularity due to low-energy particle-hole excitations. The QP peak starts at the core-electron energy ɛc, and is followed by an extended satellite (shakeup) structure at smaller ω. For photon energies ω just above threshold, ωth=-ɛc, Ac(ɛk-ω)θ(ɛk) as a function of ɛk (ω constant) is cut just behind the quasiparticle peak, and neither the tail of the MND line nor the plasmon satellites are present. The sudden (high-energy) limit is given by a convolution of Ac(ω) and a loss function, i.e., by the Berglund-Spicer two-step expression. Thus Ac(ω) alone does not give the correct photoelectron spectrum, neither at low nor at high energies. We present an extension of the quantum-mechanical (QM) models developed earlier by Inglesfield, and by Bardyszewski and Hedin to calculate Jk(ω). It includes recoil and damping, as well as shakeup effects and extrinsic losses, is exact in the high-energy limit, and allows calculations of Jk(ω) including the MND line and multiple plasmon losses. The model, which involves electrons coupled to quasibosons, is motivated by detailed arguments. As an illustration we have made quantitative calculations for a semi-infinite jellium with the density of aluminum metal and an embedded atom. The coupling functions (fluctuation potentials) between the electron and the quasibosons are related to the random-phase-approximation dielectric function, and different levels of approximations are evaluated numerically. The differences

  17. Medida da velocidade de condução nervosa motora em praticantes de três diferentes modalidades esportivas

    Directory of Open Access Journals (Sweden)

    Luís Paulo Nogueira Cabral Borges

    2013-10-01

    Full Text Available INTRODUÇÃO: Estudos da condução nervosa têm sido focados para o público em geral, porém não para atletas, havendo carência de informações sobre medidas da velocidade de condução nervosa motora (VCNM em indivíduos treinados, especialmente quando diferentes esportes são comparados. OBJETIVO: Medir a VCNM do nervo mediano e fibular comum, em três grupos de modalidades esportivas. Métodos: Foram analisados: um grupo de meio-fundistas (Gmf, n = 6, um grupo de velocistas (Gvel, n = 4 e um grupo de jogadores de handebol (Ghan, n = 5 e comparados com um grupo controle (Gcon, n = 9. Cada voluntário foi submetido a um único exame, no qual foram obtidos os dados para calcular a VCNM dos membros inferiores do Gmf e do Gvel, dos membros superiores do Ghan, e membros superiores e inferiores do Gcon. Os dados da pesquisa apresentaram distribuição normal e variâncias homogêneas, assim, utilizamos o teste t de Student para amostras independentes na comparação das médias da VCNM dos grupos de atletas com as do Gcon e as do Gvel com as do Gmf (comparações intergrupo. O teste t pareado foi usado para comparar as médias da VCNM entre membro dominante (Md e membro não dominante (Mnd (comparações intragrupo. RESULTADOS: Na análise intergrupo foram encontradas diferenças significativas nas comparações entre o Gvel e o Gcon e entre o Gmf e o Gcon (diferença apenas nas comparações entre os Md's. Por outro lado, a análise intragrupo, exibiu diferença significativa apenas nas comparações entre Md e Mnd do Ghan. CONCLUSÃO: O estudo sugere que a VCNM é beneficiada pelo esforço físico, principalmente em esportes com uso predominante dos membros inferiores, e que a maior utilização de um membro superior sobre outro pode levar a diferença significativa nos valores da VCNM do Md e Mnd.

  18. [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].

    Science.gov (United States)

    Serdiuk, A V; Levitskiĭ, G N; Miasoedov, N F; Skvortsova, V I

    2007-01-01

    The study of chronic partial denervation (CPD) and quality of life was carried out in 27 patients with definite, probable and possible diagnosis of motor neuron disease (MND) treated with semax (1% solution). The needle electromyography (EMG) was performed thrice with short-term 2 month interval (60 days before enrollment and on day 1 and day 48 of the study) in three muscles on bulbar, cervical and lumbosacral levels on the less affected side. According to Revised El-Escorial Criteria (1998) the needle EMG for diagnostic purposes was also performed in two muscles on the cervical and lumbosacral levels on the more affected side along with stimulation electroneuronmyography of motor and sensory fibers of the peripheral nerves of neck, upper and lower extremities. The open-label clinical trial of Semax (1% solution) was conducted in sequential groups of patients. The drug was administered intranasally in two 10-day-long courses with 2-weeks break in daily dose of 12 mg. Sixty days before enrollment, and on days 1, 10, 24, 34 and 48, patients were assessed by the Norris ALS, the ALS Functioning Rating Scale and the ALSAQ-40 quality of life in the ALS scale. It was shown that CPD on the early as well as on the late stages was characterized by forward-backward, but not unidirectional course, that did not allow to recommend the follow-up needle EMG with short-term interval for evaluation of drug efficacy monitoring. Early CPD stages were characterized by forward-backwards fluctuations reflecting the compensatory reinnervation process (a phenomenon of exchange of muscle fibers, more rational in view of reinnervation, between adjacent motor units) whereas on the late CPD stages these forward-backwards CPD fluctuations reflected the processes of progressive deterioration of muscle fibers and secondary demyelination of large motor axons. Semax (1% solution) does not influence either the course of CPD or the dynamics of clinical estimates, in particular the terms of ensuing

  19. HIV associated neurocognitive disorders (HAND in Malawian adults and effect on adherence to combination anti-retroviral therapy: a cross sectional study.

    Directory of Open Access Journals (Sweden)

    Christine M Kelly

    Full Text Available Little is known about the prevalence and burden of HIV associated neurocognitive disorder (HAND among patients on combination antiretroviral therapy (cART in sub-Saharan Africa. We estimated the prevalence of HAND in adult Malawians on cART and investigated the relationship between HAND and adherence to cART.HIV positive adults in Blantyre, Malawi underwent a full medical history, neurocognitive test battery, depression score, Karnofsky Performance Score and adherence assessment. The Frascati criteria were used to diagnose HAND and the Global Deficit Score (GDS was also assessed. Blood was drawn for CD4 count and plasma nevirapine and efavirenz concentrations. HIV negative adults were recruited from the HIV testing clinic to provide normative scores for the neurocognitive battery.One hundred and six HIV positive patients, with median (range age 39 (18-71 years, 73% female and median (range CD4 count 323.5 (68-1039 cells/µl were studied. Symptomatic neurocognitive impairment was present in 15% (12% mild neurocognitive disorder [MND], 3% HIV associated dementia [HAD]. A further 55% fulfilled Frascati criteria for asymptomatic neurocognitive impairment (ANI; however factors other than neurocognitive impairment could have confounded this estimate. Neither the symptomatic (MND and HAD nor asymptomatic (ANI forms of HAND were associated with subtherapeutic nevirapine/efavirenz concentrations, adjusted odds ratio 1.44 (CI. 0.234, 8.798; p = 0.696 and aOR 0.577 (CI. 0.09, 3.605; p = 0.556 respectively. All patients with subtherapeutic nevirapine/efavirenz levels had a GDS of less than 0.6, consistent with normal neurocognition.Fifteen percent of adult Malawians on cART had a diagnosis of MND or HAD. Subtherapeutic drug concentrations were found exclusively in patients with normal neurocognitive function suggesting HAND did not affect cART adherence. Further study of HAND requires more robust locally derived normative neurocognitive values and

  20. Organizational Structure in Korea's Nuclear Energy Development

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. H.; Lee, T. J. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    This paper explores the cross-sectional and dynamic analysis of nuclear related organizations in Korea to systemize them. Nuclear related organizations in Korea are classified into four large groups as commission, executive branch, public institution and private organization. Table 1 shows the nuclear related organizations in each group. AEC, NSC and their expert commission are all the commissions on nuclear energy. MEST, MKE, MFAT, MND etc. are executive branch related to nuclear energy. In addition, there are also government affiliated agencies, societies, associations and other different types of organizations carrying out tasks entrusted by the government concerning nuclear R and D and safety regulation. As for nuclear related private organizations, there are KEPCO, KHNP, KEPCO-ENC, KEPCO-NF etc

  1. Structural, electronic and magnetic properties of Mn{sub 3}N{sub 2}(0 0 1) surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero-Sánchez, J., E-mail: guerrero@ifuap.buap.mx [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Mandru, Andrada-Oana; Wang, Kangkang [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Takeuchi, Noboru [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Centro de Nanociencias y Nanotecnologia, Universidad Nacional Autónoma de México, Apartado Postal 14, Ensenada, Baja California, Codigo Postal 22800 (Mexico); Cocoletzi, Gregorio H. [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Smith, Arthur R. [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States)

    2015-11-15

    Graphical abstract: - Abstract: Spin-polarized first-principles total energy calculations have been performed to study the structural, electronic and magnetic properties of Mn{sub 3}N{sub 2}(0 0 1) surfaces. It is found that three surface terminations are energetically stable, in agreement with previous scanning tunneling microscopy experiments that have found three different electronic contrasts in their images. It is also found that in all three cases, the topmost layer has a MnN stoichiometry. Density of states calculations show a metallic behavior for all the stable structures with the most important contribution close to the Fermi level coming from the Mn-d orbitals. Our Tersoff–Hamann scanning tunneling microscopy simulations are in good agreement with previous experimental results.

  2. Estimation of stability of polynuclear rare earth complexes with EDTA in the presence of stable monocomplexonates

    International Nuclear Information System (INIS)

    Le Ba Tkhun; Kupriyanova, G.N.; Smirnova, N.S.; Martynenko, L.I.; Evseeva, A.M.

    1987-01-01

    Complexing in rare-earth-EDTA system at the mole ratio making up (M 3+ ):(H 2 A 2- )=1:1, 2:1, 5:1, (M=Nd, Yb), C H 2 A 2- =0.010, 0.015 mol/l, μ=0.5 (KCl) is studied in pH 1.6-3.0 interval by pH-metric titration technique using mathematical modelling method. A model containing MA - , MHA, M 2 A 2+ complexes for which stability constants, equalling respectively (lgK) to 15.66, 2.11, 1.06 (for neodymium complexes) and 18.70, 1.78, 0.45 (for ytterbium complexes) are determined by non-linear LSF, appears to be adequate. It is shown that binuclear complex concentration in solution with M 3+ excess is comparable to stable monocomplexonate concentration

  3. 运动神经元病认知功能损害研究现状

    Institute of Scientific and Technical Information of China (English)

    王文敏; Michael J. Strong

    2004-01-01

    目前认为运动神经元病(motor neuron diseases,MND),特别是肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是继Alzheimer病、帕金森病之后的第三种最常见的成年发病的进展性神经变性疾病。传统上认为,MND的变性过程仅限于运动神经元,临床表现为进行性致死性肌萎缩、肌无力和肢体僵硬。据流行病学资料ALS发生率1.0—1.8/10万,

  4. Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

    Directory of Open Access Journals (Sweden)

    Ágatha Oliveira-Giacomelli

    2018-04-01

    Full Text Available Since proving adenosine triphosphate (ATP functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system. In neurological disorders with associated motor symptoms, including Parkinson's disease (PD, motor neuron diseases (MND, multiple sclerosis (MS, amyotrophic lateral sclerosis (ALS, Huntington's Disease (HD, restless leg syndrome (RLS, and ataxias, alterations in purinergic receptor expression and activity have been noted, indicating a potential role for this system in disease etiology and progression. In neurodegenerative conditions, neural cell death provokes extensive ATP release and alters calcium signaling through purinergic receptor modulation. Consequently, neuroinflammatory responses, excitotoxicity and apoptosis are directly or indirectly induced. This review analyzes currently available data, which suggests involvement of the purinergic system in neuro-associated motor dysfunctions and underlying mechanisms. Possible targets for pharmacological interventions are also discussed.

  5. Earth Science Data for a Mobile Age

    Science.gov (United States)

    Oostra, D.; Chambers, L. H.; Lewis, P. M.; Baize, R.; Oots, P.; Rogerson, T.; Crecelius, S.; Coleman, T.

    2012-12-01

    Earth science data access needs to be interoperable and automatic. Recently, increasingly savvy data users combined with more complex web and mobile applications have placed increasing demands on how this Earth science data is being delivered to educators and students. The MY NASA DATA (MND) and S'COOL projects are developing a strategy to interact with the education community in the age of mobile devices and platforms. How can we provide data and meaningful scientific experiences to educational users through mobile technologies? This initiative will seek out existing technologies and stakeholders within the Earth Science community to identify datasets that are relevant and appropriate for mobile application development and use by the educational community. Targeting efforts within the educational community will give the project a better understanding of the previous attempts at data/mobile application use in the classroom and its problems. In addition, we will query developers and data providers on what successes and failures they've experienced in trying to provide data for applications designed on mobile platforms. This feedback will be implemented in new websites, applications and lessons that will provide authentic scientific experiences for students and end users. We want to create tools that help sort through the vast amounts of NASA data, and deliver it to users automatically. NASA provides millions of gigabytes of data that is publicly available through a large number of services spread across the World Wide Web. Accessing and navigating this data can be time consuming and problematic with variety of file types and methods for accessing this data. The MND project, through its' Live Access Server system, provides selected datasets that are relevant and targets National Standards of Learning for educators to easily integrate into existing curricula. In the future, we want to provide desired data to users with automatic updates, anticipate future data queries

  6. Formation mechanism of solute clusters under neutron irradiation in ferritic model alloys and in a reactor pressure vessel steel: clusters of defects; Mecanismes de fragilisation sous irradiation aux neutrons d'alliages modeles ferritiques et d'un acier de cuve: amas de defauts

    Energy Technology Data Exchange (ETDEWEB)

    Meslin-Chiffon, E

    2007-11-15

    The embrittlement of reactor pressure vessel (RPV) under irradiation is partly due to the formation of point defects (PD) and solute clusters. The aim of this work was to gain more insight into the formation mechanisms of solute clusters in low copper ([Cu] = 0.1 wt%) FeCu and FeCuMnNi model alloys, in a copper free FeMnNi model alloy and in a low copper French RPV steel (16MND5). These materials were neutron-irradiated around 300 C in a test reactor. Solute clusters were characterized by tomographic atom probe whereas PD clusters were simulated with a rate theory numerical code calibrated under cascade damage conditions using transmission electron microscopy analysis. The confrontation between experiments and simulation reveals that a heterogeneous irradiation-induced solute precipitation/segregation probably occurs on PD clusters. (author)

  7. Singularities in x-ray spectra of metals

    International Nuclear Information System (INIS)

    Mahan, G.D.

    1987-08-01

    The x-ray spectroscopies discussed are absorption, emission, and photoemission. The singularities show up in each of them in a different manner. In absorption and emission they show up as power law singularities at the thresholds frequencies. This review will emphasize two themes. First a simple model is proposed to describe this phenomena, which is now called the MND model after MAHAN-NOZIERES-DeDOMINICIS. Exact analytical solutions are now available for this model for the three spectroscopies discussed above. These analytical models can be evaluated numerically in a simple way. The second theme of this review is that great care must be used when comparing the theory to experiment. A number of factors influence the edge shapes in x-ray spectroscopy. The edge singularities play an important role, and are observed in many matals. Quantitative fits of the theory to experiment require the consideration of other factors. 51 refs

  8. Effects of regular physical activity on anthropometric and functional parameters in young and old women

    Directory of Open Access Journals (Sweden)

    Sebastião Gobbi

    2001-12-01

    Full Text Available The aim of the present study was to verify the strength levels and the arm cross-sectional-area (AMB of young and old women who practice physical activity regularly. Thirty female subjects were selected and distributed into two groups: young (G1 and old (G2. They were evaluated on maximal voluntary strength of elbow flexor muscle by 1RM (one-maximal repetition test (“biceps curl”, and the AMB, through the measures of arm circumference (CB and triceps skinfold (DCTr, which were then used with the equation proposed by Frisancho (1984: AMB (cm2 = [(CB - pDCTr2 / 4p] - 6.5, in both dominant (MD and non dominant (MND arms. Strength (kg and AMB (cm2 were analyzed by ANOVA to a significance level of 5%. The G2 strength level was significantly (p RESUMO O presente estudo teve como objetivo verificar os níveis de força e a área muscular do braço (AMB de mulheres jovens e idosas praticantes de atividade física regular. Para isso foram selecionados 30 sujeitos do sexo feminino, distribuídos em dois grupos: jovem (G1 e idoso (G2. Avaliou-se a força voluntária máxima dos músculos flexores do cotovelo pelo teste de 1RM (repetição máxima exercício “rosca unilateral” , e a AMB, através das medidas de circunferência de braço (CB e dobra cutânea tricipital (DCTr, que posteriormente foram incluídas na equação proposta por Frisancho (1984: AMB (cm = [(CB - pDCTr2 / 4p] - 6.5, em ambos os membros dominante (MD e não dominante (MND. Os valores de força (em kg e AMB (em cm2 foram analisados por ANOVA com nível de significância pré-estabelecido em 5%. O nível de força do G2 foi significativamente (p<0,01 menor que G1, tanto no MD quanto no MND. Em relação à AMB, o MND de G2 mostrou-se maior que G1, o que não ocorreu com o MD. A partir da análise dos resultados, concluiu-se que apesar do envelhecimento, a prática regular de atividade física pode prevenir a perda de massa muscular (MM. Contudo, a capacidade para gerar for

  9. Formation mechanism of solute clusters under neutron irradiation in ferritic model alloys and in a reactor pressure vessel steel: clusters of defects

    International Nuclear Information System (INIS)

    Meslin-Chiffon, E.

    2007-11-01

    The embrittlement of reactor pressure vessel (RPV) under irradiation is partly due to the formation of point defects (PD) and solute clusters. The aim of this work was to gain more insight into the formation mechanisms of solute clusters in low copper ([Cu] = 0.1 wt%) FeCu and FeCuMnNi model alloys, in a copper free FeMnNi model alloy and in a low copper French RPV steel (16MND5). These materials were neutron-irradiated around 300 C in a test reactor. Solute clusters were characterized by tomographic atom probe whereas PD clusters were simulated with a rate theory numerical code calibrated under cascade damage conditions using transmission electron microscopy analysis. The confrontation between experiments and simulation reveals that a heterogeneous irradiation-induced solute precipitation/segregation probably occurs on PD clusters. (author)

  10. Anterior cysts of the spine: a difficult differential diagnosis to amyotrophic lateral sclerosis.

    Science.gov (United States)

    Schmalbach, S; Petri, S; Götz, F; Dengler, R; Krampfl, K

    2008-11-01

    We describe three patients referred to our ALS/MND clinic with suspected diagnosis of amyotrophic lateral sclerosis (ALS). The patients were all male, middle aged, and their initial symptoms were weakness and fasciculations in upper limb muscles. Results of clinical and electrophysiological examination in all cases were in accordance with possible ALS according to the revised El Escorial criteria. Other conditions mimicking ALS appeared to be excluded by extensive technical examinations and laboratory tests. Only repeated MRI examinations revealed anterior spinal cysts several years after symptom onset. This report intends to highlight this rare and difficult differential diagnosis of ALS and underlines the value of the revised El Escorial criteria in conjunction with electrophysiology to asses the certainty of the diagnosis ALS.

  11. Assessment of performance validity in the Stroop Color and Word Test in mild traumatic brain injury patients: a criterion-groups validation design.

    Science.gov (United States)

    Guise, Brian J; Thompson, Matthew D; Greve, Kevin W; Bianchini, Kevin J; West, Laura

    2014-03-01

    The current study assessed performance validity on the Stroop Color and Word Test (Stroop) in mild traumatic brain injury (TBI) using criterion-groups validation. The sample consisted of 77 patients with a reported history of mild TBI. Data from 42 moderate-severe TBI and 75 non-head-injured patients with other clinical diagnoses were also examined. TBI patients were categorized on the basis of Slick, Sherman, and Iverson (1999) criteria for malingered neurocognitive dysfunction (MND). Classification accuracy is reported for three indicators (Word, Color, and Color-Word residual raw scores) from the Stroop across a range of injury severities. With false-positive rates set at approximately 5%, sensitivity was as high as 29%. The clinical implications of these findings are discussed. © 2012 The British Psychological Society.

  12. Nuclear morphometry in histological specimens of canine prostate cancer: Correlation with histological subtypes, Gleason score, methods of collection and survival time.

    Science.gov (United States)

    Di Donato, Guido; Laufer-Amorim, Renée; Palmieri, Chiara

    2017-10-01

    Ten normal prostates, 22 benign prostatic hyperplasia (BPH) and 29 prostate cancer (PC) were morphometrically analyzed with regard to mean nuclear area (MNA), mean nuclear perimeter (MNP), mean nuclear diameter (MND), coefficient of variation of the nuclear area (NACV), mean nuclear diameter maximum (MDx), mean nuclear diameter minimum (MDm), mean nuclear form ellipse (MNFe) and form factor (FF). The relationship between nuclear morphometric parameters and histological type, Gleason score, methods of sample collection, presence of metastases and survival time of canine PC were also investigated. Overall, nuclei from neoplastic cells were larger, with greater variation in nuclear size and shape compared to normal and hyperplastic cells. Significant differences were found between more (small acinar/ductal) and less (cribriform, solid) differentiated PCs with regard to FF (pnuclear morphometric analysis in combination with Gleason score can help in canine prostate cancer grading, thus contributing to the establishment of a more precise prognosis and patient's management. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Treatment of Motor Neuron Disease with Qi-invigorating Herbs—— A Report of 31 Cases

    Institute of Scientific and Technical Information of China (English)

    覃小兰; 杨志敏; 何德平; 刘旭生; 陈红霞; 黄燕; 张文青

    2002-01-01

    @@ The motor neuron disease (MND) refers to a group of progressive diseases with unknown reasons, which attacks the cells of the anterior horn of the spinal cord, the motor nuclei of the brain stem cranial nerves and the pyramidal cells of the cerebral motor cortex. It is characterized in clinic by atrophy of the muscles, myasthenia and even death due to paralysis of the respiratory muscle. Currently, there is still no any effective cure for this illness. 50-70% of the victims will die in 3 to 5 years, and the survival time for those with brain stem injuries is no more than two years.1 Since 1996, the authors have treated 31 cases of motor neuron disease with large dosage of qi-invigorating drugs in accordance with Prof. Liu Mocai's experience, and obtained certain therapeutic effects. A report follows.

  14. Correlations of volcanic ash texture with explosion earthquakes from vulcanian eruptions at Sakurajima volcano, Japan

    Science.gov (United States)

    Miwa, T.; Toramaru, A.; Iguchi, M.

    2009-07-01

    We compare the texture of volcanic ash with the maximum amplitude of explosion earthquakes ( Aeq) for vulcanian eruptions from Sakurajima volcano. We analyze the volcanic ash emitted by 17 vulcanian eruptions from 1974 to 1987. Using a stereoscopic microscope, we classify the glassy particles into smooth surface particles (S-type particles) and non-smooth surface particles (NS-type particles) according to their surface conditions—gloss or non-gloss appearance—as an indicator of the freshness of the particles. S-type particles are further classified into V-type particles (those including vesicles) and NV-type particles (those without vesicles) by means of examinations under a polarized microscopic of polished thin sections. Cross-correlated examinations against seismological data show that: 1) the number fraction of S-type particles (S-fraction) has a positive correlation with Aeq, 2) the number ratio of NV-type particles to V-type particles (the N/V number ratio) has a positive correlation with Aeq, and 3) for explosions accompanied with BL-type earthquake swarms, the N/V number ratio has a negative correlation with the duration of the BL-Swarms. BL-Swarms refer to the phenomenon of numerous BL-type earthquakes occurring within a few days, prior to an increase in explosive activity [Kamo, K., 1978. Some phenomena before the summit crater eruptions at Sakura-zima volcano. Bull. Volcanol. Soc. Japan., 23, 53-64]. The positive correlation between the N/V number ratio and Aeq could indicate that a large amount of separated gas from fresh magma results in a large Aeq. Plagioclase microlite textual analysis of NV-type particles from five explosive events without BL-Swarms shows that the plagioclase microlite number density (MND) and the L/ W (length/width) ratio have a positive correlation with Aeq. A comparison between textural data (MND, L/ W ratio, crystallinity) and the result of a decompression-induced crystallization experiment [Couch, S., Sparks, R

  15. How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

    Science.gov (United States)

    van Vliet, Liesbeth M; Gao, Wei; DiFrancesco, Daniel; Crosby, Vincent; Wilcock, Andrew; Byrne, Anthony; Al-Chalabi, Ammar; Chaudhuri, K Ray; Evans, Catherine; Silber, Eli; Young, Carolyn; Malik, Farida; Quibell, Rachel; Higginson, Irene J

    2016-05-10

    Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services interact. This study aimed to map the current level of connections and integration between these services. The mapping exercise was conducted in eight centres with neurology and palliative care services in the United Kingdom. The data were provided by the respective neurology and specialist palliative care teams. Questions focused on: i) catchment and population served; ii) service provision and staffing; iii) integration and relationships. Centres varied in size of catchment areas (39-5,840 square miles) and population served (142,000-3,500,000). Neurology and specialist palliative care were often not co-terminus. Service provisions for neurology and specialist palliative care were also varied. For example, neurology services varied in the number and type of provided clinics and palliative care services in the settings they work in. Integration was most developed in Motor Neuron Disease (MND), e.g., joint meetings were often held, followed by Parkinsonism (made up of Parkinson's Disease (PD), Multiple-System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), with integration being more developed for MSA and PSP) and least in Multiple Sclerosis (MS), e.g., most sites had no formal links. The number of neurology patients per annum receiving specialist palliative care reflected these differences in integration (range: 9-88 MND, 3-25 Parkinsonism, and 0-5 MS). This mapping exercise showed heterogeneity in service provision and integration between neurology and specialist palliative care services, which varied not only between sites but also between diseases. This highlights the need and opportunities for improved models of integration, which should be rigorously tested for effectiveness.

  16. Quantum many-body effects in x-ray spectra efficiently computed using a basic graph algorithm

    Science.gov (United States)

    Liang, Yufeng; Prendergast, David

    2018-05-01

    The growing interest in using x-ray spectroscopy for refined materials characterization calls for an accurate electronic-structure theory to interpret the x-ray near-edge fine structure. In this work, we propose an efficient and unified framework to describe all the many-electron processes in a Fermi liquid after a sudden perturbation (such as a core hole). This problem has been visited by the Mahan-Noziéres-De Dominicis (MND) theory, but it is intractable to implement various Feynman diagrams within first-principles calculations. Here, we adopt a nondiagrammatic approach and treat all the many-electron processes in the MND theory on an equal footing. Starting from a recently introduced determinant formalism [Phys. Rev. Lett. 118, 096402 (2017), 10.1103/PhysRevLett.118.096402], we exploit the linear dependence of determinants describing different final states involved in the spectral calculations. An elementary graph algorithm, breadth-first search, can be used to quickly identify the important determinants for shaping the spectrum, which avoids the need to evaluate a great number of vanishingly small terms. This search algorithm is performed over the tree-structure of the many-body expansion, which mimics a path-finding process. We demonstrate that the determinantal approach is computationally inexpensive even for obtaining x-ray spectra of extended systems. Using Kohn-Sham orbitals from two self-consistent fields (ground and core-excited state) as input for constructing the determinants, the calculated x-ray spectra for a number of transition metal oxides are in good agreement with experiments. Many-electron aspects beyond the Bethe-Salpeter equation, as captured by this approach, are also discussed, such as shakeup excitations and many-body wave function overlap considered in Anderson's orthogonality catastrophe.

  17. [Personalizing the reference level: gold standard to evaluate the quality of service perceived].

    Science.gov (United States)

    Rodrigo-Rincón, I; Reyes-Pérez, M; Martínez-Lozano, M E

    2014-01-01

    To know the cutoff point at which in-house Nuclear Medicine Department (MND) customers consider that the quality of service is good (personalized cutoff). We conducted a survey of the professionals who had requested at least 5 tests to the Nuclear Medicine Department. A total of 71 doctors responded (response rate: 30%). A question was added to the questionnaire for the user to establish a cutoff point for which they would consider the quality of service as good. The quality non-conformities, areas of improvement and strong points of the six questions measuring the quality of service (Likert scale 0 to 10) were compared with two different thresholds: personalized cutoff and one proposed by the service itself a priori. Test statistics: binomial and Student's t-test for paired data. A cutoff value of 7 was proposed by the service as a reference while 68.1% of respondents suggested a cutoff above 7 points (mean 7.9 points). The 6 elements of perceived quality were considered strong points with the cutoff proposed by the MND, while there were 3 detected with the personalized threshold. Thirteen percent of the answers were nonconformities with the service cutoff versus 19.2% with the personalized one, the differences being statistically significant (difference 95% CI 6.44%:0,83-12.06). The final image of the perceived quality of an in-house customer is different when using the cutoff established by the Department versus the personalized cutoff given by the respondent. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  18. Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis

    Science.gov (United States)

    Carney, Sile; Corr, Bernie; Mays, Iain; Pender, Niall; Hardiman, Orla

    2018-01-01

    Objectives Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and emotional impact of providing care in the home requires appropriate assistance and support. The objective of this analysis is to explore the needs of informal ALS caregivers across the caregiving course. Design In an open-ended question as part of a semistructured interview, caregivers were asked what would help them in their role. Interviews took place on three occasions at 4-month to 6-month intervals. Demographic, burden and quality of life data were collected, in addition to the open-ended responses. We carried out descriptive statistical analysis and thematic analysis of qualitative data. Setting and participants Home interviews at baseline (n=81) and on two further occasions (n=56, n=41) with informal caregivers of people with ALS attending the National ALS/MND Clinic at Beaumont Hospital, Dublin, Ireland. Results The majority of caregivers were family members. Hours of care provided and caregiver burden increased across the interview series. Thematic analysis identified what would help them in their role, and needs related to external support and services, psychological-emotional factors, patient-related behaviours, a cure and ‘nothing’. Themes were interconnected and their prevalence varied across the interview time points. Conclusion This study has shown the consistency and adaptation in what caregivers identified as helpful in their role, across 12–18 months of a caregiving journey. Support needs are clearly defined, and change with time and the course of caregiving. Caregivers need support from family, friends and healthcare professionals in managing their tasks and the emotional demands of caregiving. Identifying the specific needs of informal caregivers should enable health professionals to provide tailored supportive interventions

  19. Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder.

    Science.gov (United States)

    Mitchell, Alex J; Sheth, Bhavisha; Gill, John; Yadegarfar, Motahare; Stubbs, Brendon; Yadegarfar, Mohammad; Meader, Nick

    2017-07-01

    To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate. Depression was examined on 147 occasions from 2days to 7years after stroke (mean 6.87months, N=33 in acute, N=43 in rehabilitation and N=69 in the community/outpatients). Across 128 analyses involving 15,573 patients assessed for major depressive disorder (MDD), the point prevalence of depression was 17.7% (95% CI=15.6% to 20.0%) 0.65 analyses involving 9720 patients determined MnD was present in 13.1% in all settings (95% CI=10.9% to 15.8%). Dysthymia was present in 3.1% (95% CI=2.1% to 5.3%), adjustment disorder in 6.9% (95% CI=4.6 to 9.7%) and anxiety in 9.8% (95% CI=5.9% to 14.8%). Any depressive disorder was present in 33.5% (95% CI=30.3% to 36.8%). The relative risk of any depressive disorder was higher following left (dominant) hemisphere stroke, aphasia, and among people with a family history and past history of mood disorders. Depression, adjustment disorder and anxiety are common after stroke. Risk factors are aphasia, dominant hemispheric lesions and past personal/family history of depression but not time since stroke. Copyright © 2017. Published by Elsevier Inc.

  20. Nd(III) and Dy(III) coordination compounds based on 1H-tetrazolate-5-acetic acid ligands: Synthesis, crystal structures and catalytic properties

    Energy Technology Data Exchange (ETDEWEB)

    Li Qiaoyun; Chen Dianyu; He Minghua [Jiangsu Laboratory of Advanced Functional Materials, Department of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu (China); Yang Gaowen, E-mail: ygwsx@126.com [Jiangsu Laboratory of Advanced Functional Materials, Department of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu (China); Shen Lei; Zhai Chun; Shen Wei; Gu Kun; Zhao Jingjing [Jiangsu Laboratory of Advanced Functional Materials, Department of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu (China)

    2012-06-15

    Reactions of 1H-tetrazolate-5-acetic acid(H{sub 2}tza) with Nd(NO{sub 3}){sub 3}{center_dot}6H{sub 2}O or Dy(NO{sub 3}){sub 3}{center_dot}6H{sub 2}O with the presence of KOH under solvothermal conditions, produced two new coordination compounds, [M{sub 2}(tza){sub 3}(H{sub 2}O){sub 6}]{center_dot}2H{sub 2}O [M=Nd(1), Dy(2)]. Both compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compounds 1 and 2 reveal 1D structures via bridging tza as linker. Furthermore, the compounds 1 and 2 showed a specific and good catalytic behavior for the polymerization of styrene, and the polymerization showed controlled characteristics. - Graphical Abstract: Two new coordination compounds, [M{sub 2}(tza){sub 3}(H{sub 2}O){sub 6}]{center_dot}2H{sub 2}O [M=Nd(1), Dy(2)] have been synthesis. 1 and 2 reveal 1D structures via bridging tza as linker, and showed a specific and good catalytic behavior for the polymerization of styrene. Highlights: Black-Right-Pointing-Pointer we have reported two novel compounds formed by H{sub 2}tza and Nd(III) or Dy(III). Black-Right-Pointing-Pointer Compounds 1 and 2 were found to have catalysis property for the photo-polymerization of styrene. Black-Right-Pointing-Pointer The high molecular weight polymers with narrow molecular weight distributions were obtained.

  1. Mortality from multiple sclerosis in British military personnel.

    Science.gov (United States)

    Harris, E Clare; Palmer, Keith T; Cox, Vanessa; Darnton, Andrew; Osman, John; Coggon, David

    2017-08-01

    While analysing trends in occupational mortality in England and Wales, we noticed an unexpectedly elevated proportion of deaths from multiple sclerosis (MS) among men in the armed forces. To document and explore possible explanations for the observed excess. We analysed data on underlying cause of death and last full-time occupation for 3,688,916 deaths among men aged 20-74 years in England and Wales during 1979-2010, calculating proportional mortality ratios (PMRs) standardised for age. We compared PMRs for MS in the armed forces with those for each main social class, and in selected other occupations. We also compared PMRs for MS with those for motor neurone disease (MND). The overall PMR for MS in the armed forces during 1979-2010 was 243 (95%CI 203-288). The excess was apparent in each of three separate decades of study (PMRs, ranging from 220 to 259), and across the entire age range. PMRs for MS were not elevated to the same extent in comparator occupations, nor in any of the main social classes. There was no parallel increase in PMRs for MND. These findings suggest that the high proportional mortality from MS in British military personnel is unlikely to have occurred by chance, or as an artefact of the method of investigation. However, the only military cohort study with published results on MS does not support an increased risk. It would be useful to analyse data on MS from other established military cohorts, to check for evidence of a hazard. © The Author 2017. Published by Oxford University Press on behalf of the Society of Occupational Medicine.

  2. Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study

    Directory of Open Access Journals (Sweden)

    Eun-Joo Kim

    2014-07-01

    Full Text Available Background: We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD from the Clinical Research Center for Dementia of South Korea (CREDOS-FTD registry. Methods: A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive and functional assessments, a screening test for aphasia, behavioral questionnaires, motor assessments, and brain MRI or PET. Results: In our registry, 78 patients were classified as having been diagnosed with behavioral-variant FTD (bvFTD, 70 with semantic dementia (SD, 33 with progressive nonfluent aphasia (PNFA, and 8 with motor neuron disease plus syndrome (MND-plus. The patients with language variants of dementia were older than those with bvFTD. There were no differences in sex ratio, duration of illness, or level of education among the four subgroups. Overall, the patients with bvFTD showed a significantly better performance in cognitive tests. A higher frequency of motor symptoms and a lower frequency of behavioral symptoms were found in PNFA than in bvFTD and SD. The Global Language Index was significantly lower in SD than in bvFTD and PNFA. The MND-plus group had a poorer performance than all the others in all cognitive domains. Conclusion: The neuropsychological, behavioral, motor, and language characteristics of the four subtypes are comparable with those from other series. However, the proportion of SD (37.0%, which was similar to that of bvFTD (41.3%, was higher in our registry than in other series.

  3. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes

    Directory of Open Access Journals (Sweden)

    Kyoung-in Cho

    2017-05-01

    Full Text Available The pathogenic drivers of sporadic and familial motor neuron disease (MND, such amyotrophic lateral sclerosis (ALS, are unknown. MND impairs the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cause-effect mechanisms of Ran GTPase modulators in motoneuron pathobiology have remained elusive. The cytosolic and peripheral nucleoporin Ranbp2 is a crucial regulator of the Ran GTPase cycle and of the proteostasis of neurological disease-prone substrates, but the roles of Ranbp2 in motoneuron biology and disease remain unknown. This study shows that conditional ablation of Ranbp2 in mouse Thy1 motoneurons causes ALS syndromes with hypoactivity followed by hindlimb paralysis, respiratory distress and, ultimately, death. These phenotypes are accompanied by: a decline in the nerve conduction velocity, free fatty acids and phophatidylcholine of the sciatic nerve; a reduction in the g-ratios of sciatic and phrenic nerves; and hypertrophy of motoneurons. Furthermore, Ranbp2 loss disrupts the nucleocytoplasmic partitioning of the import and export nuclear receptors importin β and exportin 1, respectively, Ran GTPase and histone deacetylase 4. Whole-transcriptome, proteomic and cellular analyses uncovered that the chemokine receptor Cxcr4, its antagonizing ligands Cxcl12 and Cxcl14, and effector, latent and activated Stat3 all undergo early autocrine and proteostatic deregulation, and intracellular sequestration and aggregation as a result of Ranbp2 loss in motoneurons. These effects were accompanied by paracrine and autocrine neuroglial deregulation of hnRNPH3 proteostasis in sciatic nerve and motoneurons, respectively, and post-transcriptional downregulation of metalloproteinase 28 in the sciatic nerve. Mechanistically, our results demonstrate that Ranbp2 controls nucleocytoplasmic, chemokine and metalloproteinase 28 signaling, and proteostasis of substrates that are crucial to motoneuronal homeostasis and

  4. Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency.

    Science.gov (United States)

    Shaw, Kit L; Garabedian, Elizabeth; Mishra, Suparna; Barman, Provaboti; Davila, Alejandra; Carbonaro, Denise; Shupien, Sally; Silvin, Christopher; Geiger, Sabine; Nowicki, Barbara; Smogorzewska, E Monika; Brown, Berkley; Wang, Xiaoyan; de Oliveira, Satiro; Choi, Yeong; Ikeda, Alan; Terrazas, Dayna; Fu, Pei-Yu; Yu, Allen; Fernandez, Beatriz Campo; Cooper, Aaron R; Engel, Barbara; Podsakoff, Greg; Balamurugan, Arumugam; Anderson, Stacie; Muul, Linda; Jagadeesh, G Jayashree; Kapoor, Neena; Tse, John; Moore, Theodore B; Purdy, Ken; Rishi, Radha; Mohan, Kathey; Skoda-Smith, Suzanne; Buchbinder, David; Abraham, Roshini S; Scharenberg, Andrew; Yang, Otto O; Cornetta, Kenneth; Gjertson, David; Hershfield, Michael; Sokolic, Rob; Candotti, Fabio; Kohn, Donald B

    2017-05-01

    Autologous hematopoietic stem cell transplantation (HSCT) of gene-modified cells is an alternative to enzyme replacement therapy (ERT) and allogeneic HSCT that has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when combined with reduced intensity conditioning (RIC) and ERT cessation. Clinical safety and therapeutic efficacy were evaluated in a phase II study. Ten subjects with confirmed ADA-deficient SCID and no available matched sibling or family donor were enrolled between 2009 and 2012 and received transplantation with autologous hematopoietic CD34+ cells that were modified with the human ADA cDNA (MND-ADA) γ-retroviral vector after conditioning with busulfan (90 mg/m2) and ERT cessation. Subjects were followed from 33 to 84 months at the time of data analysis. Safety of the procedure was assessed by recording the number of adverse events. Efficacy was assessed by measuring engraftment of gene-modified hematopoietic stem/progenitor cells, ADA gene expression, and immune reconstitution. With the exception of the oldest subject (15 years old at enrollment), all subjects remained off ERT with normalized peripheral blood mononuclear cell (PBMC) ADA activity, improved lymphocyte numbers, and normal proliferative responses to mitogens. Three of nine subjects were able to discontinue intravenous immunoglobulin replacement therapy. The MND-ADA vector was persistently detected in PBMCs (vector copy number [VCN] = 0.1-2.6) and granulocytes (VCN = 0.01-0.3) through the most recent visits at the time of this writing. No patient has developed a leukoproliferative disorder or other vector-related clinical complication since transplant. These results demonstrate clinical therapeutic efficacy from gene therapy for ADA-deficient SCID, with an excellent clinical safety profile. ClinicalTrials.gov NCT00794508. Food and Drug Administration Office of Orphan Product Development award, RO1 FD003005; NHLBI awards, PO1 HL73104 and Z01 HG000122; UCLA

  5. Utilization of agrarian potentials'. Challenges for agriculturists and society; Agrar-Potenziale nutzen.. Herausforderung fuer Landwirte und Gesellschaft

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Within the scope of the meeting 'Utilization of agrarian potentials' held by Deutsche Landwirtschaftliche Gesellschaft e.V. at 8th to 10th January, 2008, in Muenster (Federal Republic of Germany) the following lectures were held: (a) The world markets move - challenges for production (Joachim von Braun); (b) Global markets - future terms of references for the agriculture: guidelines for future strategies under new objectives (Juergen Zeddies); (c) Structural change and globalization - challenges for cooperative societies as market partners of the agriculture (Andreas Schueren, Dieter Hake); (d) More efficient utilization of scarce resources - we need changed thought patterns and decision patterns (Carl-Albrecht Bartmer); (e) Optimal intensities in the agriculture - the requirement of the hour: Adjustment of production at optimal intensity (Theo Jachmann); (f) Growth potentials of selected locations for the agriculture - area productivity in the international comparison (Klaus Nehring); (g) Optimization of the intensities in the crop farming - new challenges, possible adjustments (Hubertus Paetow); (h) Considering inventory management? The fertilization of tomorrow (Klaus Muenchhoff); (i) Value added chain of grain - quality requirements from the view of the traceability: The test system grain (Petra Melisch); (j) Young farmers full of optimism - current results of interview for the estimation of the situation and future and to efficiency potentials (Marika Prasser-Strith); (k) The responsibility for the soil - challenges at technology for cultivation and tillage (Franz-Georg von Busse); (l) The sustainable use of the plough land is an obligation - plough land is precious. (Lothar Hoevelmann); (m) Development of milk cattle companies till 2015 - strategic future planning now necessarily (Johannes Thomsen); (n) The ethical responsibility for a sustainable and global development - agriculture and nutrition (Beatrice van Saan-Klein, Markus Vogt); (o) Ethical

  6. Foreword

    Directory of Open Access Journals (Sweden)

    Rafael Raffaelli

    2004-01-01

    Full Text Available It is with immense satisfaction that we introduce the opening issue of the INTERthesis Interdisciplinary International Journal, created with the aim of encouraging and contributing to the interdisciplinary discussion. In this first issue, we have included five articles which have an extremely wide-ranging subject matter .The article by Carlos Walter Porto Gonçalves argues the geopolitical question implied in the purported dichotomy between hunger and environment, analyzing the environmental - social consequences of the use of an agrarian and agricultural pattern incompatible with the populations' needs throughout several regions of the world, thus generating a contradiction between the increase of food production and the concomitant increase of hunger. Javier Bustamante Donas analyzes the educational parameters, which are essential for the conversion of the society of information into a society of knowledge, pondering that the lack of reflection upon the human dimensions of technology causes disarray that threatens its purposes of greatest reach. Marika Moisseeff examines the conjugal relationship and the autonomy, focusing the couple as an initiative experience, which is settled by the development of intimacy along their connubial life, taking into account the differentiation between the spouses and the learning of respect for each one's space. Paulo Henrique Battaglin Machado evaluates the impact of public policies on the society, by means of a methodology of life quality rates assessment, considering intraurban differentials, and analyzes the inequalities and inequities among regions in Curitiba, confronting the urban model and the city image. Finally, Salvador Giner highlights the importance of sociology in the study of the human condition, emphasizing its multidimensional characteristic and the need of a moral competence that searches the union between the rational intention and the human freedom evinced in the utopia. We hope these

  7. Sharing and Empathy in Digital Spaces: Qualitative Study of Online Health Forums for Breast Cancer and Motor Neuron Disease (Amyotrophic Lateral Sclerosis).

    Science.gov (United States)

    Hargreaves, Sarah; Bath, Peter A; Duffin, Suzanne; Ellis, Julie

    2018-06-14

    The availability of an increasing number of online health forums has altered the experience of living with a health condition, as more people are now able to connect and support one another. Empathy is an important component of peer-to-peer support, although little is known about how empathy develops and operates within online health forums. The aim of this paper is to explore how empathy develops and operates within two online health forums for differing health conditions: breast cancer and motor neuron disease (MND), also known as amyotrophic lateral sclerosis. This qualitative study analyzed data from two sources: interviews with forum users and downloaded forum posts. Data were collected from two online health forums provided by UK charities: Breast Cancer Care and the Motor Neurone Disease Association. We analyzed 84 threads from the breast cancer forum and 52 from the MND forum. Threads were purposively sampled to reflect varied experiences (eg, illness stages, topics of conversation, and user characteristics). Semistructured interviews were conducted with 14 Breast Cancer Care forum users and five users of the MND forum. All datasets were analyzed thematically using Braun and Clarke's six-phase approach and combined to triangulate the analysis. We found that empathy develops and operates through shared experiences and connections. The development of empathy begins outside the forum with experiences of illness onset and diagnosis, creating emotional and informational needs. Users came to the forum and found their experiences and needs were shared and understood by others, setting the empathetic tone and supportive ethos of the forum. The forum was viewed as both a useful and meaningful space in which they could share experiences, information, and emotions, and receive empathetic support within a supportive and warm atmosphere. Empathy operated through connections formed within this humane space based on similarity, relationships, and shared feelings. Users

  8. The Use of Social Media and Mobile applications in content delivery for the MY NASA DATA and SCOOL Projects in support of Education and Outreach Initiatives

    Science.gov (United States)

    Lewis, P. M.; Oostra, D.; Moore, S. W.; Crecelius, S. A.

    2011-12-01

    So you have a social media site for the project you are working on. Now what? How do you know if you are reaching your target audience? What are the demographics of those that you are reaching? These are just a few of the questions to ask when venturing into the social media world as a way to further your outreach opportunities. With this important information you will have the ability to make small changes "on the fly", or to switch focus to other Web 2.0 tools for the project. An important aspect to social media tools as an outreach strategy is the ease of development and implementation for use in reaching your targeted audience. They are also equally easy to remove from use. This allows a project to shift to a new method of communication should your metrics point you in that direction. The MY NASA DATA (MND) project enables K-12 teachers, students and citizen scientists to explore the large volumes of satellite data that NASA collects from space. With the large number of interactions that surround conference and outreach meetings, social media plays several important roles in the project. The main function of social media is to be an open channel for communication and discovery of the project. The other important role is as a vehicle to share new information, media and other useful educational tools. With a target age of middle school and older, the MY NASA DATA project is able to effectively utilize a wide variety of social media tools through proper monitoring of metrics and usage. Some of the social media tools utilized by the MY NASA DATA project include, Facebook, YouTube and the Observe Your World blog. Students' Clouds Observations On-Line (S'COOL) is a hands-on project, which supports NASA research on the Earth's climate. Students are engaged in identifying cloud-types and levels and sending that information to NASA. Since the topic of clouds is a popular one in many elementary curricula, the target age for the S'COOL project is younger than that of the

  9. Validation of the International HIV Dementia Scale as a Screening Tool for HIV-Associated Neurocognitive Disorders in a German-Speaking HIV Outpatient Clinic.

    Directory of Open Access Journals (Sweden)

    Victor Marin-Webb

    Full Text Available HIV-associated neurocognitive disorders (HAND are widely present among people living with HIV. Especially its milder forms, asymptomatic neurocognitive impairment (ANI and mild neurocognitive disorder (MND, remain highly prevalent worldwide. Diagnosing these conditions is subject to a time and resource consuming neuropsychological assessment. Selecting patients at a higher risk of cognitive impairment by using a simple but effective screening tool helps to organise access to further neuropsychological diagnosis. The International HIV Dementia Scale (IHDS has until now been a well-established screening tool in African and American countries, however these populations' demographics defer significantly from ours, so using the same parameters could be ineffective.To calculate the prevalence of this condition among people attending an HIV outpatient clinic in Berlin and to validate the use of the IHDS as a screening tool for HAND in a German-speaking population.We screened 480 HIV-infected patients using the IHDS, 89% of them were on a stable antiretroviral treatment. Ninety of them completed a standardised neuropsychological battery of tests and a specific cognitive complaints questionnaire. The same procedure was applied to a control group of 30 HIV-negative participants. HAND diagnosis was established according to the Frascati criteria.The overall prevalence of HAND in our cohort was 43% (20% ANI, 17% MND and 6% HIV-associated dementia. The optimal cut-off on the IHDS for detecting HAND cases was set at 11 and achieved both a sensitivity and a specificity of 80%. When specifically screening for the more severe form of HAND, HIV-associated dementia, a cut-off value of 10 offered an increase in both sensitivity (94% and specificity (86%. The Youden Index for diagnostic accuracy was 0.6 and 0.8, respectively.The prevalence of HAND was comparable to the reported by recent studies performed in countries with a similar economic development. The study

  10. Validation of the International HIV Dementia Scale as a Screening Tool for HIV-Associated Neurocognitive Disorders in a German-Speaking HIV Outpatient Clinic.

    Science.gov (United States)

    Marin-Webb, Victor; Jessen, Heiko; Kopp, Ute; Jessen, Arne B; Hahn, Katrin

    2016-01-01

    HIV-associated neurocognitive disorders (HAND) are widely present among people living with HIV. Especially its milder forms, asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorder (MND), remain highly prevalent worldwide. Diagnosing these conditions is subject to a time and resource consuming neuropsychological assessment. Selecting patients at a higher risk of cognitive impairment by using a simple but effective screening tool helps to organise access to further neuropsychological diagnosis. The International HIV Dementia Scale (IHDS) has until now been a well-established screening tool in African and American countries, however these populations' demographics defer significantly from ours, so using the same parameters could be ineffective. To calculate the prevalence of this condition among people attending an HIV outpatient clinic in Berlin and to validate the use of the IHDS as a screening tool for HAND in a German-speaking population. We screened 480 HIV-infected patients using the IHDS, 89% of them were on a stable antiretroviral treatment. Ninety of them completed a standardised neuropsychological battery of tests and a specific cognitive complaints questionnaire. The same procedure was applied to a control group of 30 HIV-negative participants. HAND diagnosis was established according to the Frascati criteria. The overall prevalence of HAND in our cohort was 43% (20% ANI, 17% MND and 6% HIV-associated dementia). The optimal cut-off on the IHDS for detecting HAND cases was set at 11 and achieved both a sensitivity and a specificity of 80%. When specifically screening for the more severe form of HAND, HIV-associated dementia, a cut-off value of 10 offered an increase in both sensitivity (94%) and specificity (86%). The Youden Index for diagnostic accuracy was 0.6 and 0.8, respectively. The prevalence of HAND was comparable to the reported by recent studies performed in countries with a similar economic development. The study confirms

  11. Avaliação isocinética em atletas da seleção brasileira de futebol de 5

    Directory of Open Access Journals (Sweden)

    Luis Felipe Castelli Correia de Campos

    2015-06-01

    Full Text Available INTRODUÇÃO: A força muscular (FM dos membros inferiores é um dos principais componentes exigidos para as ações específicas durante a prática do futebol de 5 e, quando apresentam níveis insuficientes, desequilíbrios bilaterais elevados ou acentuada diferença na razão agonista/antagonista (RAA são fatores que contribuem para o desenvolvimento de lesões musculoesqueléticas. OBJETIVO: A proposta deste estudo foi avaliar os níveis de torque máximo, a diferença bilateral na produção de força e a razão convencional das musculaturas flexoras e extensoras do joelho em diferentes velocidades de execução. MÉTODOS: Participaram do estudo 11 atletas deficientes visuais. Os atletas foram submetidos à avaliação antropométrica para determinação da composição corporal e submetidos à avaliação com dinamômetro isocinético para a mensuração dos níveis de desequilíbrio muscular e razão convencional. RESULTADOS: Nos movimentos concêntricos da musculatura flexora foram observadas diferenças significativas no pico de torque (PT entre os membros dominante (MD e não dominante (MND na velocidade de 60°.s-1 e 180°.s-1, no pico de torque normalizado (PTN a 60°.s-1 e na velocidade de 180°.s-1 para os músculos extensores. Na RAA, observou-se diferença significativa entre MD e MND, e níveis aceitáveis de RAA em ambas as pernas, de acordo com o proposto para o futebol convencional. CONCLUSÃO: Espera-se que os resultados do presente estudo possam contribuir para os processos de prevenção, treinamento e reabilitação de atleta de futebol de 5, como também, servirem como parâmetros para futuros estudos.

  12. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood

    International Nuclear Information System (INIS)

    Kanavouras, Konstantinos; Tzatzarakis, Manolis N.; Mastorodemos, Vasileios; Plaitakis, Andreas; Tsatsakis, Aristidis M.

    2011-01-01

    Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing progressive motor neuron disease, who was chronically exposed to pesticides and organic solvents. The patient presented with leg spasticity and developed gradually clinical signs suggestive of amyotrophic lateral sclerosis, which was supported by the neurophysiologic and radiological findings. Our report is an evidence based case of combined exposure to organochlorine (DDTs), organophosphate pesticides (OPs) and organic solvents as confirmed by laboratory analysis in samples of blood and hair confirming systematic exposure. The concentration of non-specific dialkylphosphates metabolites (DAPs) of OPs in hair (dimethyphopshate (DMP) 1289.4 pg/mg and diethylphosphate (DEP) 709.4 pg/mg) and of DDTs (opDDE 484.0 pg/mg, ppDDE 526.6 pg/mg, opDDD 448.4 pg/mg, ppDDD + opDDT 259.9 pg/mg and ppDDT 573.7 pg/mg) were considerably significant. Toluene and n-hexane were also detected in blood on admission at hospital and quantified (1.23 and 0.87 μg/l, respectively), while 3 months after hospitalization blood testing was found negative for toluene and n-hexane and hair analysis was provided decrease levels of HCHs, DDTs and DAPs. -- Highlights: ► Exposure to pesticides and organic solvents might be a risk factor for sporadic MND. ► We report a patient who developed progressive upper and lower motor neuron disease. ► The patient had a history of occupational exposure to pesticides and solvents. ► High DDTs’ levels and increased levels of DMP and DEP were measured in his hair. ► The patients’ exposure to chemicals might have played a role in MND development.

  13. Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres

    Science.gov (United States)

    Raffelt, David A.; Smith, Robert E.; Ridgway, Gerard R.; Tournier, J-Donald; Vaughan, David N.; Rose, Stephen; Henderson, Robert; Connelly, Alan

    2015-01-01

    by comparing apparent fibre density between motor neurone disease (MND) patients with control subjects. The MND results illustrate the benefit of fixel-specific statistical inference in white matter regions that contain crossing fibres. PMID:26004503

  14. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood

    Energy Technology Data Exchange (ETDEWEB)

    Kanavouras, Konstantinos [Department of Neurology, Medical School, University of Crete, Heraklion, Crete (Greece); Tzatzarakis, Manolis N. [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece); Mastorodemos, Vasileios; Plaitakis, Andreas [Department of Neurology, Medical School, University of Crete, Heraklion, Crete (Greece); Tsatsakis, Aristidis M., E-mail: aris@med.uoc.gr [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)

    2011-11-15

    Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing progressive motor neuron disease, who was chronically exposed to pesticides and organic solvents. The patient presented with leg spasticity and developed gradually clinical signs suggestive of amyotrophic lateral sclerosis, which was supported by the neurophysiologic and radiological findings. Our report is an evidence based case of combined exposure to organochlorine (DDTs), organophosphate pesticides (OPs) and organic solvents as confirmed by laboratory analysis in samples of blood and hair confirming systematic exposure. The concentration of non-specific dialkylphosphates metabolites (DAPs) of OPs in hair (dimethyphopshate (DMP) 1289.4 pg/mg and diethylphosphate (DEP) 709.4 pg/mg) and of DDTs (opDDE 484.0 pg/mg, ppDDE 526.6 pg/mg, opDDD 448.4 pg/mg, ppDDD + opDDT 259.9 pg/mg and ppDDT 573.7 pg/mg) were considerably significant. Toluene and n-hexane were also detected in blood on admission at hospital and quantified (1.23 and 0.87 {mu}g/l, respectively), while 3 months after hospitalization blood testing was found negative for toluene and n-hexane and hair analysis was provided decrease levels of HCHs, DDTs and DAPs. -- Highlights: Black-Right-Pointing-Pointer Exposure to pesticides and organic solvents might be a risk factor for sporadic MND. Black-Right-Pointing-Pointer We report a patient who developed progressive upper and lower motor neuron disease. Black-Right-Pointing-Pointer The patient had a history of occupational exposure to pesticides and solvents. Black-Right-Pointing-Pointer High DDTs' levels and increased levels of DMP and DEP were measured in his hair. Black-Right-Pointing-Pointer The patients' exposure to chemicals might

  15. Developmental Coordination Disorder, an umbrella term for motor impairments in children: nature and co-morbid disorders

    Directory of Open Access Journals (Sweden)

    Laurence eVaivre-Douret

    2016-04-01

    Full Text Available Background:Developmental Coordination Disorder (DCD defines a heterogeneous class of children exhibiting marked impairment in motor coordination as a general group of deficits in fine and gross motricity (subtype mixed group common to all research studies, and with a variety of other motor disorders that have been little investigated. No consensus about symptoms and aetiology has been established. Methods: Data from 58 children aged 6 to 13 years with DCD were collected on DSM-IV criteria, similar to DSM- 5 criteria. They had no other medical condition and inclusion criteria were strict (born full-term, no medication, no occupational /physical therapy. Multivariate statistical methods were used to evidence relevant interactions between discriminant features in a general DCD subtype group and to highlight specific co-morbidities. The study examined age-calibrated standardized scores from completed assessments of psychological, neuropsychological and neuropsychomotor functions, and more specifically the presence of minor neurological dysfunctions (MND including neurological soft signs (NSS, without evidence of focal neurological brain involvement. These were not considered in most previous studies. Results: Findings show the salient DCD markers for the mixed subtype (imitation of gestures, digital perception, digital praxia, manual dexterity, upper and lower limb coordination, versus surprising co-morbidities, with 33% of MND with mild spasticity from phasic stretch reflex (PSR, not associated with the above impairments but rather with sitting tone (p= .004 and dysdiadochokinesia (p= .011. PSR was not specific to a DCD subtype but was related to increased impairment of coordination between upper and lower limbs and manual dexterity. Our results highlight the major contribution of an extensive neuro-developmental assessment (mental and physical. Discussion: The present study provides important new evidence in favour of a complete physical

  16. Clinical efficacy of gene-modified stem cells in adenosine deaminase–deficient immunodeficiency

    Science.gov (United States)

    Shaw, Kit L.; Garabedian, Elizabeth; Mishra, Suparna; Barman, Provaboti; Davila, Alejandra; Carbonaro, Denise; Shupien, Sally; Silvin, Christopher; Geiger, Sabine; Nowicki, Barbara; Smogorzewska, E. Monika; Brown, Berkley; Wang, Xiaoyan; de Oliveira, Satiro; Choi, Yeong; Ikeda, Alan; Terrazas, Dayna; Fu, Pei-Yu; Yu, Allen; Fernandez, Beatriz Campo; Cooper, Aaron R.; Engel, Barbara; Podsakoff, Greg; Balamurugan, Arumugam; Anderson, Stacie; Muul, Linda; Jagadeesh, G. Jayashree; Kapoor, Neena; Tse, John; Moore, Theodore B.; Purdy, Ken; Rishi, Radha; Mohan, Kathey; Skoda-Smith, Suzanne; Buchbinder, David; Abraham, Roshini S.; Scharenberg, Andrew; Yang, Otto O.; Cornetta, Kenneth; Gjertson, David; Hershfield, Michael; Sokolic, Rob; Candotti, Fabio

    2017-01-01

    BACKGROUND. Autologous hematopoietic stem cell transplantation (HSCT) of gene-modified cells is an alternative to enzyme replacement therapy (ERT) and allogeneic HSCT that has shown clinical benefit for adenosine deaminase–deficient (ADA-deficient) SCID when combined with reduced intensity conditioning (RIC) and ERT cessation. Clinical safety and therapeutic efficacy were evaluated in a phase II study. METHODS. Ten subjects with confirmed ADA-deficient SCID and no available matched sibling or family donor were enrolled between 2009 and 2012 and received transplantation with autologous hematopoietic CD34+ cells that were modified with the human ADA cDNA (MND-ADA) γ-retroviral vector after conditioning with busulfan (90 mg/m2) and ERT cessation. Subjects were followed from 33 to 84 months at the time of data analysis. Safety of the procedure was assessed by recording the number of adverse events. Efficacy was assessed by measuring engraftment of gene-modified hematopoietic stem/progenitor cells, ADA gene expression, and immune reconstitution. RESULTS. With the exception of the oldest subject (15 years old at enrollment), all subjects remained off ERT with normalized peripheral blood mononuclear cell (PBMC) ADA activity, improved lymphocyte numbers, and normal proliferative responses to mitogens. Three of nine subjects were able to discontinue intravenous immunoglobulin replacement therapy. The MND-ADA vector was persistently detected in PBMCs (vector copy number [VCN] = 0.1–2.6) and granulocytes (VCN = 0.01–0.3) through the most recent visits at the time of this writing. No patient has developed a leukoproliferative disorder or other vector-related clinical complication since transplant. CONCLUSION. These results demonstrate clinical therapeutic efficacy from gene therapy for ADA-deficient SCID, with an excellent clinical safety profile. TRIAL REGISTRATION. ClinicalTrials.gov NCT00794508. FUNDING. Food and Drug Administration Office of Orphan Product

  17. Pregnancy and live birth after follicle-stimulating hormone treatment for an infertile couple including a male affected by Sertoli cell-only syndrome

    Directory of Open Access Journals (Sweden)

    Paulis G

    2017-10-01

    Full Text Available Gianni Paulis,1,2 Luca Paulis,3 Gennaro Romano,4 Carmen Concas,5 Marika Di Sarno,5 Renata Pagano,5 Antonio Di Filippo,5 Maria Luisa Di Petrillo5 1Andrology Center, Regina Apostolorum Hospital, Rome, Italy; 2Department of Uro-Andrology, Castelfidardo Medical Team, Peyronie’s Disease Care Center, Rome, Italy; 3Section of Pharmacology and Research, Department of Uro-Andrology, Castelfidardo Medical Team, Peyronie’s Disease Care Center, Rome, Italy; 4Department of Urologic Oncology, Italian League Against Cancer, Avellino, Italy; 5Department of Reproductive Medicine and Biology, Caran Center, Caserta, Italy Abstract: In males with nonobstructive azoospermia, one of the main histopathologic patterns of the testis is Sertoli cell-only syndrome (SCOS, in which no germ cells are present and only Sertoli cells are contained in the seminiferous tubules. There is not any formal treatment for this pathological condition. However, several studies reported the possibility to perform testicular sperm extraction in patients with SCOS, although, according to some authors, sperm retrieval is possible only in the presence of focal spermatogenesis. We report the case of an infertile couple in whom the 30-year-old male was azoospermic. After the diagnosis, the patient underwent multiple bilateral testicular biopsies, which showed a histological pattern corresponding to SCOS. We administered a cycle of hormone stimulation followed by medically assisted procreation procedures to the male patient. Therefore, the male patient was treated with follicle-stimulating hormone gonadotropin for a total of 7 months (150 IU recombinant human follicle stimulating hormone three times per week. After carrying out a new multiple testicular sperm extraction, several spermatozoa were microscopically observed, and it was then possible to perform an intracytoplasmic sperm injection with subsequent embryo transfer of the blastocyst into the wife’s uterus, and so pregnancy was

  18. Fishing for causes and cures of motor neuron disorders.

    Science.gov (United States)

    Patten, Shunmoogum A; Armstrong, Gary A B; Lissouba, Alexandra; Kabashi, Edor; Parker, J Alex; Drapeau, Pierre

    2014-07-01

    Motor neuron disorders (MNDs) are a clinically heterogeneous group of neurological diseases characterized by progressive degeneration of motor neurons, and share some common pathological pathways. Despite remarkable advances in our understanding of these diseases, no curative treatment for MNDs exists. To better understand the pathogenesis of MNDs and to help develop new treatments, the establishment of animal models that can be studied efficiently and thoroughly is paramount. The zebrafish (Danio rerio) is increasingly becoming a valuable model for studying human diseases and in screening for potential therapeutics. In this Review, we highlight recent progress in using zebrafish to study the pathology of the most common MNDs: spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP). These studies indicate the power of zebrafish as a model to study the consequences of disease-related genes, because zebrafish homologues of human genes have conserved functions with respect to the aetiology of MNDs. Zebrafish also complement other animal models for the study of pathological mechanisms of MNDs and are particularly advantageous for the screening of compounds with therapeutic potential. We present an overview of their potential usefulness in MND drug discovery, which is just beginning and holds much promise for future therapeutic development. © 2014. Published by The Company of Biologists Ltd.

  19. Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (Mandrillus sphinx).

    Science.gov (United States)

    Apetrei, Cristian; Sumpter, Beth; Souquiere, Sandrine; Chahroudi, Ann; Makuwa, Maria; Reed, Patricia; Ribeiro, Ruy M; Pandrea, Ivona; Roques, Pierre; Silvestri, Guido

    2011-12-01

    Simian immunodeficiency virus (SIV) infection in African nonhuman primate (NHP) natural hosts is usually nonpathogenic, despite high levels of virus replication. We have previously shown that chronic SIV infection in sooty mangabeys (SMs) and African green monkeys (AGMs) is associated with low levels of immune activation and bystander T cell apoptosis. To compare these features with those observed in another natural host, the mandrill (MND), we conducted a cross-sectional survey of the 23 SIV-infected and 25 uninfected MNDs from the only semifree colony of mandrills available worldwide. Viral loads (VLs) were determined and phenotypic and functional analysis of peripheral blood- and lymph node-derived lymphocytes was performed. We found that mandrills chronically infected with SIVmnd-1 or SIVmnd-2 have similar levels of viral replication, and we observed a trend toward lower CD4+ T cell counts in chronically SIVmnd-2-infected MNDs than SIVmnd-1-infected MNDs. No correlation between CD4+ T cell counts and VLs in SIV-infected MNDs could be established. Of note, the levels of T cell activation, proliferation, and apoptosis were comparable between SIVmnd-1- and SIVmnd-2-infected MNDs and to those observed in uninfected animals, with the only exception being an increase in tumor necrosis factor alpha-producing CD8+ T cells in SIVmnd-2-infected MNDs. Overall, these findings recapitulate previous observations in SIV-infected SMs and AGMs and lend further evidence to the hypothesis that low levels of immune activation protect natural SIV hosts from disease progression.

  20. Immunological alterations and associated diseases in mandrills (Mandrillus sphinx) naturally co-infected with SIV and STLV.

    Science.gov (United States)

    Souquière, Sandrine; Makuwa, Maria; Sallé, Bettina; Lepelletier, Yves; Mortreux, Franck; Hermine, Olivier; Kazanji, Mirdad

    2014-04-01

    Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4(+) and CD8(+) T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4(+) and CD8(+) T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Numerical generation and study of synthetic bainitic microstructures

    International Nuclear Information System (INIS)

    Osipov, N.; Gourgues-Lorenzon, A.F.; Cailletaud, G.; Diard, O.; Marini, B.

    2006-01-01

    Models classically used to describe the probability of brittle fracture in nuclear power plants are written on the macroscopic scale. Its is not easy to surely capture the physical phenomena in such a type of approach, so that the application of the models far from their identification domain (temperature history, loading path) may become questionable. To improve the quality of the prediction of resistance and life time, microstructural information, describing the heterogeneous character of the material and its deformation mechanisms has to be taken into consideration. This paper is devoted to 16MND5 bainitic steel. Bainitic packets grow in former austenitic grains, and are not randomly oriented. Knowing the macroscopic stress is thus not sufficient to describe the stress-strain state in ferrite. An accurate model must take into account the actual microstructure, in order to provide realistic local stress and strain fields, to be used as inputs of a new class of cleavage models based on the local behavior. The paper shows the approach used to generate a synthetic microstructure and demonstrates that the resulting morphologies present a quantitative agreement with the experimental images. (authors)

  2. Electronic structure and magnetism of Mn-doped GaSb for spintronic applications: A DFT study

    Energy Technology Data Exchange (ETDEWEB)

    Seña, N.; Dussan, A. [Departamento de Física, Grupo de Materiales Nanoestructurados y sus Aplicaciones, Universidad Nacional de Colombia, Bogotá (Colombia); Mesa, F. [Facultad de Ciencias Naturales y Matemáticas, Grupo NanoTech, Universidad del Rosario, Bogotá (Colombia); Castaño, E.; González-Hernández, R., E-mail: rhernandezj@uninorte.edu.co [Grupo de Investigación en Física Aplicada, Departamento de Física, Universidad del Norte, Barranquilla (Colombia)

    2016-08-07

    We have carried out first-principles spin polarized calculations to obtain comprehensive information regarding the structural, magnetic, and electronic properties of the Mn-doped GaSb compound with dopant concentrations: x = 0.062, 0.083, 0.125, 0.25, and 0.50. The plane-wave pseudopotential method was used in order to calculate total energies and electronic structures. It was found that the Mn{sub Ga} substitution is the most stable configuration with a formation energy of ∼1.60 eV/Mn-atom. The calculated density of states shows that the half-metallic ferromagnetism is energetically stable for all dopant concentrations with a total magnetization of about 4.0 μ{sub B}/Mn-atom. The results indicate that the magnetic ground state originates from the strong hybridization between Mn-d and Sb-p states, which agree with previous studies on Mn-doped wide gap semiconductors. This study gives new clues to the fabrication of diluted magnetic semiconductors.

  3. Frontotemporal dementias: Recent advances and current controversies

    Directory of Open Access Journals (Sweden)

    Leyton Cristian

    2010-10-01

    Full Text Available Frontotemporal dementia (FTD syndromes comprise a heterogeneous group of neurodegenerative conditions characterized by atrophy in the frontal and temporal lobes. Three main clinical variants are recognized: Behavioral variant (bv-FTD, Semantic dementia (SD, and Progressive nonfluent aphasia (PNFA. However, logopenic/phonological (LPA variant has been recently described, showing a distinctive pattern of brain atrophy and often associated to Alzheimer′s disease pathology. The diagnosis of FTD is challenging, since there is clinical, pathological, and genetic overlap between the variants and other neurodegenerative diseases, such as motoneuron disease (MND and corticobasal degeneration (CBD. In addition, patients with gene mutations (tau and progranulin display an inconsistent clinical phenotype and the correspondence between the clinical variant and its pathology is unpredictable. New cognitive tests based on social cognition and emotional recognition together with advances in molecular pathology and genetics have contributed to an improved understanding. There is now a real possibility of accurate biomarkers for early diagnosis. The present review concentrates on new insights and debates in FTD.

  4. Illustration of the WPS benefit through BATMAN test series: Tests on large specimens under WPS loading configurations

    International Nuclear Information System (INIS)

    Yuritzinn, T.; Ferry, L.; Chapuliot, S.; Mongabure, P.; Moinereau, D.; Dahl, A.; Gilles, P.

    2008-01-01

    To study the effects of warm pre-stressing on the toughness of reactor pressure vessel steel, the 'Commissariat a l Energie Atomique', in collaboration with 'Electricite de France' and AREVA-NP, has made a study combining modeling and a series of experiments on large specimens submitted to a thermal shock or isothermal cooling. The tests were made on 18MND5 ferritic steel bars, containing a short or large fatigue pre-crack. The effect of 'warm pre-stressing' was confirmed, in the two cases of a fast thermal shock creating a gradient across the thickness of the bar and for gradual uniform cooling. In both cases, no propagation was observed during the thermal transient. Fracture occurred under low temperature conditions, at the end of the test when the tensile load was increased. The failure loads recorded were substantially higher than during pre-stressing. To illustrate the benefit of the WPS effect, numerical interpretations were performed using either global approach or local approach criteria. WPS effect and capability of models to predict it were then clearly shown. (authors)

  5. Metabolomics in amyotrophic lateral sclerosis: how far can it take us?

    Science.gov (United States)

    Blasco, H; Patin, F; Madji Hounoum, B; Gordon, P H; Vourc'h, P; Andres, C R; Corcia, P

    2016-03-01

    Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. Alongside identification of aetiologies, development of biomarkers is a foremost research priority. Metabolomics is one promising approach that is being utilized in the search for diagnosis and prognosis markers. Our aim is to provide an overview of the principal research in metabolomics applied to ALS. References were identified using PubMed with the terms 'metabolomics' or 'metabolomic' and 'ALS' or 'amyotrophic lateral sclerosis' or 'MND' or 'motor neuron disorders'. To date, nine articles have reported metabolomics research in patients and a few additional studies examined disease physiology and drug effects in patients or models. Metabolomics contribute to a better understanding of ALS pathophysiology but, to date, no biomarker has been validated for diagnosis, principally due to the heterogeneity of the disease and the absence of applied standardized methodology for biomarker discovery. A consensus on best metabolomics methodology as well as systematic independent validation will be an important accomplishment on the path to identifying the long-awaited biomarkers for ALS and to improve clinical trial designs. © 2016 EAN.

  6. The SSVEP-Based BCI Text Input System Using Entropy Encoding Algorithm

    Directory of Open Access Journals (Sweden)

    Yeou-Jiunn Chen

    2015-01-01

    Full Text Available The so-called amyotrophic lateral sclerosis (ALS or motor neuron disease (MND is a neurodegenerative disease with various causes. It is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, and difficulty in speaking, swallowing, and breathing. The severe disabled always have a common problem that is about communication except physical malfunctions. The steady-state visually evoked potential based brain computer interfaces (BCI, which apply visual stimulus, are very suitable to play the role of communication interface for patients with neuromuscular impairments. In this study, the entropy encoding algorithm is proposed to encode the letters of multilevel selection interface for BCI text input systems. According to the appearance frequency of each letter, the entropy encoding algorithm is proposed to construct a variable-length tree for the letter arrangement of multilevel selection interface. Then, the Gaussian mixture models are applied to recognize electrical activity of the brain. According to the recognition results, the multilevel selection interface guides the subject to spell and type the words. The experimental results showed that the proposed approach outperforms the baseline system, which does not consider the appearance frequency of each letter. Hence, the proposed approach is able to ease text input interface for patients with neuromuscular impairments.

  7. Sialorrhoea: How to Manage a Frequent Complication of Motor Neuron Disease

    Directory of Open Access Journals (Sweden)

    Andrea Pellegrini

    2015-08-01

    Full Text Available Sialorrhoea, the unintentional loss of saliva through the mouth, is the frequent complication of neurological disorders affecting strength or coordination of oropharyngeal muscles, such as motor neuron disease/amyotrophic lateral sclerosis (MND/ALS or Parkinson’s disease. Sialorrhoea might affect up to 42% of ALS patients, with almost half of them having poorly managed symptoms. Sialorrhoea can impair patients’ social life, while dermatological complications, such as skin rashes, may arise due to constant exposure to moisture. Moreover, the excess mouth-retained saliva in ALS patients may lead to serious complications, such as choking, which causes anxiety, and aspiration with the consequent pneumonia. The inclusion of a sialorrhoea-related item in the ALS functional rating scale testifies both the incidence and importance of sialorrhoea during the ALS clinical course. Because of the progressive nature of ALS, presence and severity of sialorrhoea should be assessed at every visit and, when present, active treatment pursued. Available treatments include behavioural therapy, i.e. techniques to enhance periodic swallowing of saliva, systemic or local anticholinergic medications, botulinum toxin injection, electron beam irradiation, and surgical techniques. This review paper briefly describes the available options with related side-effects and current guideline recommendations for managing sialorrhoea in ALS patients.

  8. Fishing for causes and cures of motor neuron disorders

    Directory of Open Access Journals (Sweden)

    Shunmoogum A. Patten

    2014-07-01

    Full Text Available Motor neuron disorders (MNDs are a clinically heterogeneous group of neurological diseases characterized by progressive degeneration of motor neurons, and share some common pathological pathways. Despite remarkable advances in our understanding of these diseases, no curative treatment for MNDs exists. To better understand the pathogenesis of MNDs and to help develop new treatments, the establishment of animal models that can be studied efficiently and thoroughly is paramount. The zebrafish (Danio rerio is increasingly becoming a valuable model for studying human diseases and in screening for potential therapeutics. In this Review, we highlight recent progress in using zebrafish to study the pathology of the most common MNDs: spinal muscular atrophy (SMA, amyotrophic lateral sclerosis (ALS and hereditary spastic paraplegia (HSP. These studies indicate the power of zebrafish as a model to study the consequences of disease-related genes, because zebrafish homologues of human genes have conserved functions with respect to the aetiology of MNDs. Zebrafish also complement other animal models for the study of pathological mechanisms of MNDs and are particularly advantageous for the screening of compounds with therapeutic potential. We present an overview of their potential usefulness in MND drug discovery, which is just beginning and holds much promise for future therapeutic development.

  9. Recruitment of RecA homologs Dmc1p and Rad51p to the double-strand break repair site initiated by meiosis-specific endonuclease VDE (PI-SceI).

    Science.gov (United States)

    Fukuda, Tomoyuki; Ohya, Yoshikazu

    2006-02-01

    During meiosis, VDE (PI-SceI), a homing endonuclease in Saccharomyces cerevisiae, introduces a double-strand break (DSB) at its recognition sequence and induces homologous recombinational repair, called homing. Meiosis-specific RecA homolog Dmc1p, as well as mitotic RecA homolog Rad51p, acts in the process of meiotic recombination, being required for strand invasion and exchange. In this study, recruitment of Dmc1p and Rad51p to the VDE-induced DSB repair site is investigated by chromatin immunoprecipitation assay. It is revealed that Dmc1p and Rad51p are loaded to the repair site in an independent manner. Association of Rad51p requires other DSB repair proteins of Rad52p, Rad55p, and Rad57p, while loading of Dmc1p is facilitated by the different protein, Sae3p. Absence of Tid1p, which can bind both RecA homologs, appears specifically to cause an abnormal distribution of Dmc1p. Lack of Hop2, Mnd1p, and Sae1p does not impair recruitment of both RecA homologs. These findings reveal the discrete functions of each strand invasion protein in VDE-initiated homing, confirm the similarity between VDE-initiated homing and Spo11p-initiated meiotic recombination, and demonstrate the availability of VDE-initiated homing for the study of meiotic recombination.

  10. Interaction and dynamics of homologous pairing protein 2 (HOP2) and DNA studied by MD simulation

    Science.gov (United States)

    Moktan, Hem; Pezza, Roberto; Zhou, Donghua

    2015-03-01

    The homologous pairing protein 2 (Hop2) plays an important role in meiosis and DNA repair. Together with protein Mnd1, Hop2 enhances the strand invasion activity of recombinase Dmc1 by over 30 times, facilitating proper synapsis of homologous chromosomes. We recently determined the NMR structure of the N-terminal domain of Hop2 and proposed a model of Protein-DNA complex based on NMR chemical shift perturbations and mutagenesis studies (Moktan, J Biol Chem 2014 10.1074/jbc.M114.548180). However structure and dynamics of the complex have not been studied at the atomic level yet. Here, we used classical MD simulations to study the interactions between the N-terminal HOP2 and DNA. The simulated results indicate that helix3 (H3) interacts with DNA in major groove and wing1 (W1) interacts mostly in minor groove mainly via direct hydrogen bonds. Also it is found that binding leads to reduced fluctuations in both protein and DNA. Several water bridge interactions have been identified. The residue-wise contributions to the interaction energy were evaluated. Also the functional motion of the protein is analyzed using principal component analysis. The results confirmed the importance of H3 and W1 for the stability of the complex, which is consistent with our previous experimental studies.

  11. Structural stability and the electronic and magnetic properties of ferrimagnetic Mn_4N(0 0 1) surfaces

    International Nuclear Information System (INIS)

    Guerrero-Sánchez, J.; Takeuchi, Noboru

    2017-01-01

    Highlights: • Surface formation energy calculations demonstrate a N-dependent stability. • The magnetic alignment of these surfaces remains bulk-like, in a ferrimagnetic fashion. • A ferrimagnetic behavior in both structures is confirmed by density of states calculations. - Abstract: We have carried out spin-polarized first principles calculations to describe the surface stability and the electronic and magnetic properties of Mn_4N(0 0 1) surfaces. Results show two different surface terminations with different N content. The surface formation energies indicate that for manganese rich conditions the most stable structure is a MnN terminated surface. Whereas, from intermediate to nitrogen rich conditions, a MnN terminated surface with excess of nitrogen atoms is the most favorable. The stability of these surfaces can be traced to the formation of Mn–N bonds at the surface. The stable surfaces are Ferrimagnetic along the direction perpendicular to the surface, retaining a bulk-like behavior. However, there is a decrease in the Mn magnetic moments due to the presence of the surface. Density of states shows an asymmetric behavior, inherent of a Ferrimagnetic state. Finally, the surfaces are metallic with the main contributions around the Fermi level coming from the Mn-d orbitals. The knowledge about the atomic arrangements of the Mn_4N surfaces may serve to explain and understand the formation of more complex and technologically applicable ferromagnetic/ferrimagnetic and antiferromagnetic/ferrimagnetic heterostructures.

  12. Hormone replacement therapy improves contractile function and myonuclear organization of single muscle fibres from postmenopausal monozygotic female twin pairs.

    Science.gov (United States)

    Qaisar, Rizwan; Renaud, Guillaume; Hedstrom, Yvette; Pöllänen, Eija; Ronkainen, Paula; Kaprio, Jaakko; Alen, Markku; Sipilä, Sarianna; Artemenko, Konstantin; Bergquist, Jonas; Kovanen, Vuokko; Larsson, Lars

    2013-05-01

    Ageing is associated with a decline in muscle mass and strength leading to increased physical dependency in old age. Postmenopausal women experience a greater decline than men of similar age in parallel with the decrease in female sex steroid hormone production. We recruited six monozygous female twin pairs (55-59 years old) where only one twin pair was on hormone replacement therapy (HRT use = 7.8 ± 4.3 years) to investigate the association of HRT with the cytoplasmic volume supported by individual myonuclei (myonuclear domain (MND) size,) together with specific force at the single fibre level. HRT use was associated with a significantly smaller (∼27%; P muscle fibres expressing the type I but not the IIa myosin heavy chain (MyHC) isoform. In comparison to non-users, higher specific force was recorded in HRT users both in muscle fibres expressing type I (∼27%; P fibre-type dependent, i.e. the higher specific force in fast-twitch muscle fibres was primarily caused by higher force per cross-bridge while slow-twitch fibres relied on both a higher number and force per cross-bridge. HRT use had no effect on fibre cross-sectional area (CSA), velocity of unloaded shortening (V0) and relative proportion of MyHC isoforms. In conclusion, HRT appears to have significant positive effects on both regulation of muscle contraction and myonuclei organization in postmenopausal women.

  13. Cobalt products from real waste fractions of end of life lithium ion batteries.

    Science.gov (United States)

    Pagnanelli, Francesca; Moscardini, Emanuela; Altimari, Pietro; Abo Atia, Thomas; Toro, Luigi

    2016-05-01

    An innovative process was optimized to recover Co from portable Lithium Ion Batteries (LIB). Pilot scale physical pretreatment was performed to recover electrodic powder from LIB. Co was extracted from electrodic powder by a hydrometallurgical process including the following main stages: leaching (by acid reducing conditions), primary purification (by precipitation of metal impurities), solvent extraction with D2EPHA (for removal of metal impurities), solvent extraction with Cyanex 272 (for separation of cobalt from nickel), cobalt recovery (by precipitation of cobalt carbonate). Tests were separately performed to identify the optimal operating conditions for precipitation (pH 3.8 or 4.8), solvent extraction with D2EHPA (pH 3.8; Mn/D2EHPA=4; 10% TBP; two sequential extractive steps) and solvent extraction with Cyanex 272 (pH 3.8; Cyanex/Cobalt=4, 10% TBP, one extractive step). The sequence of optimized process stages was finally performed to obtain cobalt carbonate. Products with different degree of purity were obtained depending on the performed purification steps (precipitation with or without solvent extraction). 95% purity was achieved by implementation of the process including the solvent extraction stages with D2EHPA and Cyanex 272 and final washing for sodium removal. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs.

    Science.gov (United States)

    Levine, Timothy P; Daniels, Rachel D; Gatta, Alberto T; Wong, Louise H; Hayes, Matthew J

    2013-02-15

    Fronto-temporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, also called motor neuron disease, MND) are severe neurodegenerative diseases that show considerable overlap at the clinical and cellular level. The most common single mutation in families with FTD or ALS has recently been mapped to a non-coding repeat expansion in the uncharacterized gene C9ORF72. Although a plausible mechanism for disease is that aberrant C9ORF72 mRNA poisons splicing, it is important to determine the cellular function of C9ORF72, about which nothing is known. Sensitive homology searches showed that C9ORF72 is a full-length distant homologue of proteins related to Differentially Expressed in Normal and Neoplasia (DENN), which is a GDP/GTP exchange factor (GEF) that activates Rab-GTPases. Our results suggest that C9ORF72 is likely to regulate membrane traffic in conjunction with Rab-GTPase switches, and we propose to name the gene and its product DENN-like 72 (DENNL72).

  15. Balance evaluation in haemophilic preadolescent patients using Nintendo Wii Balance Board®.

    Science.gov (United States)

    Pérez-Alenda, S; Carrasco, J J; Aguilar-Rodríguez, M; Martínez-Gómez, L; Querol-Giner, M; Cuesta-Barriuso, R; Torres-Ortuño, A; Querol, F

    2017-01-01

    Alterations in the musculoskeletal system, especially in the lower limbs, limit physical activity and affect balance and walking. Postural impairments in haemophilic preteens could increase the risk of bleeding events and deteriorate the physical condition, promoting the progression of haemophilic arthropathy. This study aims to evaluate static postural balance in haemophilic children, assessed by means of the Wii Balance Board ® (WBB). Nineteen children with haemophilia and 19 without haemophilia aged 9-10 years, have participated in this study. Postural balance was assessed by performing four tests, each one lasting 15 s: bipodal eyes open (BEO), bipodal eyes closed (BEC), monopodal dominant leg (MD) and monopodal non-dominant leg (MND). Two balance indices, standard deviation of amplitude (SDA) and standard deviation of velocity (SDV) were calculated in the anterior-posterior (AP) and medial-lateral (ML) directions. Index values were higher in haemophilic group and the differences were statistically significant (P balance in the haemophilic cohort compared to the control group. Accordingly, physiotherapy programmes, physical activity and sports should be designed to improve the postural balance with the aim of preventing joint deterioration and improving quality of life. © 2016 John Wiley & Sons Ltd.

  16. Early diagnosis of amyotrophic lateral sclerosis mimic syndromes: pros and cons of current clinical diagnostic criteria.

    Science.gov (United States)

    Cortés-Vicente, Elena; Pradas, Jesús; Marín-Lahoz, Juan; De Luna, Noemi; Clarimón, Jordi; Turon-Sans, Janina; Gelpí, Ellen; Díaz-Manera, Jordi; Illa, Isabel; Rojas-Garcia, Ricard

    2017-08-01

    To describe the frequency and clinical characteristics of patients referred to a tertiary neuromuscular clinic as having amyotrophic lateral sclerosis (ALS) but who were re-diagnosed as having an ALS mimic syndrome, and to identify the reasons that led to the revision of the diagnosis. We reviewed the final diagnosis of all patients prospectively registered in the Sant Pau-MND register from 1 January 2004 to 31 December 2015. A detailed clinical evaluation and a clinically-guided electrophysiological study were performed at first evaluation. Twenty of 314 (6.4%) patients included were re-diagnosed as having a condition other than ALS, in 18 cases already at first evaluation. An alternative specific diagnosis was identified in 17 of those 20, consisting of a wide range of conditions. The main finding leading to an alternative diagnosis was the result of the electrophysiological study. Fifty per cent did not fulfil the El Escorial revised criteria (EECr) for ALS. The most common clinical phenotype at onset in patients with ALS mimic syndromes was progressive muscular atrophy (PMA). Misdiagnosing ALS is still a common problem. Early identification of ALS mimic syndromes is possible based on atypical clinical features and a clinically-guided electrophysiological study. Patients should be attended in specialised centres. The application of EECr helps to identify ALS misdiagnoses.

  17. Bainitic steels behavior at different temperatures: study of cementite using neutron and synchrotron radiations

    International Nuclear Information System (INIS)

    Ouahab, Razane

    2012-01-01

    The multi-scale experimental characterization of bainitic steels has been the subject of this research. Two two-phase steels ferrite-cementite were chosen: a 16MND5 steel used to design RPW reactors (Reactor Pressurized Water) and a 2C40 steel. In order to study the mechanical behavior of each phase individually, different thermomechanical characterization tools have been considered. The originality of this work comes from the use of two techniques: in situ tensile tests combined to synchrotron radiation and nano indentation. A major interest is given to the behavior of cementite. The stresses reached in this phase were determined by two methods. First, analyzes have been performed in ferritic phase by XRD and a mixture law has been used to estimate the stress values in cementite. Then, analyzes have been carried out directly in each phase using synchrotron radiation. The results show that the mixture law is a good tool to describe the stress distribution in each phase of the studied steels. However, it may be not enough because it doesn't take into account the morphology of the carbide and highly depends on the volume fraction of the cementite: an uncertainty of ± 0.2 % can lead to stress variation of ± 1000 MPa. The local properties of cementite were also analyzed by nano indentation. The primary results have confirmed that the carbide hardness is 2-3 times greater than the hardness of the matrix [fr

  18. Phenotypic and genotypic studies of ALS cases in ALS-SMA families.

    Science.gov (United States)

    Corcia, Philippe; Vourc'h, Patrick; Blasco, Helene; Couratier, Philippe; Dangoumau, Audrey; Bellance, Remi; Desnuelle, Claude; Viader, Fausto; Pautot, Vivien; Millecamps, Stephanie; Bakkouche, Salah; Salachas, FranÇois; Andres, Christian R; Meininger, Vincent; Camu, William

    2018-03-01

    Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most frequent motor neuron disorders in adulthood and infancy, respectively. There is a growing literature supporting common pathophysiological patterns between those disorders. One important clinical issue for that is the co-occurrence of both diseases within a family. To collect families in which ALS and SMA patients co-exist and describe the phenotype and the genotype of ALS patients. Nine families with co-occurrence of SMA and ALS have been gathered over the last 15 years. Epidemiological, phenotype and genetic status were collected. Out of the nine families, six corresponded to the criteria of familial ALS (FALS). Clinical data were available for 11 patients out of the 15 ALS cases. Mean age of onset was 58.5 years, site of onset was lower limbs in nine cases (81.8%), median duration was 22 months. Four ALS patients carried a mutation: three mutations in SOD1 gene (G147N in two cases and one with E121G) and one repeat expansion in the C9ORF72 gene. Three patients had abnormal SMN1 copy numbers. While the high proportion of familial history of ALS cases in these ALS-SMA pedigrees could have suggested that these familial clusters of the two most frequent MND rely on a genetic background, we failed to exclude that this occurred by chance.

  19. Structural stability and the electronic and magnetic properties of ferrimagnetic Mn{sub 4}N(0 0 1) surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero-Sánchez, J., E-mail: guerrero@cnyn.unam.mx; Takeuchi, Noboru

    2017-06-15

    Highlights: • Surface formation energy calculations demonstrate a N-dependent stability. • The magnetic alignment of these surfaces remains bulk-like, in a ferrimagnetic fashion. • A ferrimagnetic behavior in both structures is confirmed by density of states calculations. - Abstract: We have carried out spin-polarized first principles calculations to describe the surface stability and the electronic and magnetic properties of Mn{sub 4}N(0 0 1) surfaces. Results show two different surface terminations with different N content. The surface formation energies indicate that for manganese rich conditions the most stable structure is a MnN terminated surface. Whereas, from intermediate to nitrogen rich conditions, a MnN terminated surface with excess of nitrogen atoms is the most favorable. The stability of these surfaces can be traced to the formation of Mn–N bonds at the surface. The stable surfaces are Ferrimagnetic along the direction perpendicular to the surface, retaining a bulk-like behavior. However, there is a decrease in the Mn magnetic moments due to the presence of the surface. Density of states shows an asymmetric behavior, inherent of a Ferrimagnetic state. Finally, the surfaces are metallic with the main contributions around the Fermi level coming from the Mn-d orbitals. The knowledge about the atomic arrangements of the Mn{sub 4}N surfaces may serve to explain and understand the formation of more complex and technologically applicable ferromagnetic/ferrimagnetic and antiferromagnetic/ferrimagnetic heterostructures.

  20. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range

    International Nuclear Information System (INIS)

    Tanguy, B.

    2001-07-01

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

  1. Spectroscopy of selected metal-containing diatomic molecules

    Science.gov (United States)

    Gordon, Iouli E.

    Fourier transform infrared emission spectra of MnH and MnD were observed in the ground X7Sigma+ electronic state. The vibration-rotation bands from v = 1 → 0 to v = 3 → 2 for MnH, and from v = 1 → 0 to v = 4 → 3 for MnD were recorded at an instrumental resolution of 0.0085 cm-1. Spectroscopic constants were determined for each vibrational level and equilibrium constants were found from a Dunham-type fit. The equilibrium vibrational constant oe for MnH was found to be 1546.84518(65) cm-1, the equilibrium rotational constant Be was found to be 5.6856789(103) cm-1 and the equilibrium bond distance re was determined to be 1.7308601(47) A. New high resolution emission spectra of CoH and CoD molecules have been recorded in the 640 nm to 3.5 mum region using a Fourier transform spectrometer. Many bands were observed for the A'3phi- X3phi electronic transition of CoH and CoD. In addition, a new [13.3]4 electronic state was found by observing the [13.3]4-X3phi3 and [13.3]4- X3phi4 transitions in the spectrum of CoD. Analysis of the transitions with DeltaO = 0, +/-1 provided more accurate values of spin-orbit splittings between O = 4 and O = 3 components. The ground state for both molecules was fitted both to band and Dunham-type constants. The estimated band constants of the perturbed upper states were also obtained. The emission spectrum of gas-phase YbO has been investigated using a Fourier transform spectrometer. A total of 8 red-degraded bands in the range 9 800--11 300 cm-1 were recorded at a resolution of 0.04 cm-1. Because of the multiple isotopomers present in the spectra, only 3 bands were rotationally analyzed. Perturbations were identified in two of these bands and all 3 transitions were found to terminate at the X1Sigma+ ground electronic state. The electronic configurations that give rise to the observed states are discussed and molecular parameters for all of the analyzed bands are reported. Electronic spectra of the previously unobserved EuH and Eu

  2. Soil aggregate stability within the morphologically diverse area

    Science.gov (United States)

    Jaksik, Ondrej; Kodesova, Radka; Kubis, Adam; Klement, Ales; Fer, Miroslav

    2013-04-01

    This study evaluates the effect of soil erosion on properties of topsoil especially on soil aggregate stability. Study was performed on morphologically diverse study site (6 ha area) in loess region of Southern Moravia, Czech Republic. The region has been under uninterrupted agricultural use since the middle of the Holocene. Haplic Chernozem is an original dominant soil unit in the area, nowadays progressively transformed into different soil units along with intensive soil erosion. There are eroded phases of Chernozem, Regosol (the steepest and heavily eroded parts of the study area), colluvial Chernozem and Colluvial soil (base slope). Sampling spots were selected in order to represent diverse soil units and morphological units. Soil samples were taken from the topsoil, carefully transported to the laboratory and consequently air dried. Following soil properties were measured: pH_KCl, pH_CaCl2, soil organic matter content (SOM), carbonate content (CO3), content of iron and manganese (in ammonium oxalate extract, Feo and Mn_o, and dithionite-citrate extract, Fed and Mn_d), and stability of soil aggregates using two different methods. The indexes of water stable aggregates (WSA) were determined using the procedure presented by Nimmo and Perkins (2002). The three methods proposed by Le Bissonnais (1996) were also used to study various destruction mechanisms. The fast wetting test (KV1) was applied to study aggregate slaking due to the compression of the entrapped air (mechanism similar to the WSA test). The slow wetting test (KV2) was used to evaluate aggregate disintegration caused by the micro cracking due to the different swelling, and physico-chemical dispersion due to the osmotic stress. The shaking after prewetting test (KV3) was utilized to study the mechanical aggregate breakdown. Terrain attributes were evaluated from digital terrain model. In general the lowest soil aggregate stability was observed on steep slopes, which were highly impacted by soil erosion

  3. PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis.

    Science.gov (United States)

    Granito, Alessandro; Yang, Wei-Hong; Muratori, Luigi; Lim, Mark J; Nakajima, Ayako; Ferri, Silvia; Pappas, Georgios; Quarneti, Chiara; Bianchi, Francesco B; Bloch, Donald B; Muratori, Paolo

    2010-01-01

    Some patients with primary biliary cirrhosis (PBC) have antinuclear antibodies (ANAs). These ANAs include the "multiple nuclear dots" (MND) staining pattern, targeting promyelocytic leukemia protein (PML) nuclear body (NB) components, such as "speckled 100-kD" protein (Sp100) and PML. A new PML NB protein, designated as Sp140, was identified using serum from a PBC patient. The aim of this study was to analyze the immune response against Sp140 protein in PBC patients. We studied 135 PBC patients and 157 pathological controls with type 1 autoimmune hepatitis, primary sclerosing cholangitis, and systemic lupus erythematosus. We used indirect immunofluorescence and a neuroblastoma cell line expressing Sp140 for detecting anti-Sp140 antibodies, and a commercially available immunoblot for detecting anti-Sp100 and anti-PML antibodies. Anti-Sp140 antibodies were present in 20 (15%) PBC patients but not in control samples, with a higher frequency in antimitochondrial antibody (AMA)-negative cases (53 vs. 9%, P<0.0001). Anti-Sp140 antibodies were found together with anti-Sp100 antibodies in all but one case (19 of 20, 90%) and with anti-PML antibodies in 12 (60%) cases. Anti-Sp140 positivity was not associated with a specific clinical feature of PBC. Our study identifies Sp140 as a new, highly specific autoantigen in PBC for the first time. The very frequent coexistence of anti-Sp140, anti-Sp100 and anti-PML antibodies suggests that the NB is a multiantigenic complex in PBC and enhances the diagnostic significance of these reactivities, which are particularly useful in AMA-negative cases.

  4. FE-simulation of the viscoplastic behaviour of different RPV steels in the frame of in-vessel melt retentions scenarios

    International Nuclear Information System (INIS)

    Altstadt, E.; Willschuetz, H.G.; Mueller, G.

    2004-01-01

    Assuming the hypothetical scenario of a severe accident with subsequent core meltdown and formation of a melt pool in the reactor pressure vessel (RPV) lower plenum of a Light Water Reactor (LWR) leads to the question about the behavior of the RPV. One accident management strategy could be to stabilize the in-vessel debris configuration in the RPV as one major barrier against uncontrolled release of heat and radio nuclides. To get an improved understanding and knowledge of the melt pool convection and the vessel creep and possible failure processes and modes occurring during the late phase of a core melt down accident the FOREVER-experiments (Failure Of REactor VEssel Retention) have been performed at the Division of Nuclear Power Safety of the Royal Institute of Technology Stockholm. These experiments are simulating the behavior of the lower head of the RPV under the thermal loads of a convecting melt pool with decay heating, and under the pressure loads that the vessel experiences in a depressurization scenario. The geometrical scale of the experiments is 1:10 compared to a common LWR. This paper deals with the experimental, numerical, and metallographical results of the creep failure experiment EC-FOREVER-4, where the American pressure vessel steel SA533B was applied for the lower head. For comparison the results of the experiment EC-FOREVER-3B, build of the French 16MND5 steel, are discussed, too. Emphasis is put on the differences in the viscoplastic behaviour of different heats of the RPV steel. For this purpose, the creep tests in the frame of the LHF/OLHF experiments are reviewed, too. As a hypothesis it is stated that the sulphur content could be responsible for differences in the creep behaviour. (orig.)

  5. Understanding the stability of Fe incorporation within Mn_3N_2(0 0 1) surfaces: An ab-initio study

    International Nuclear Information System (INIS)

    Guerrero-Sánchez, J.; Mandru, Andrada-Oana; Takeuchi, Noboru; Cocoletzi, Gregorio H.; Smith, Arthur R.

    2016-01-01

    Graphical abstract: - Highlights: • The Fe incorporation into inner layers of the Mn_3N_2 surfaces is stable in all range of chemical potential. • Displaced Mn atoms forming cluster-like structures induce the stability of incorporated Fe atoms. • Antiferromagnetic alignment in the [0 0 1] direction and in-plane Ferromagnetic Fe–Fe and Fe–Mn alignments are the same as in Mn_3N_2 bulk structure. • Incorporated Fe layers contribute to the metallic character of these surfaces. - Abstract: We present first principles spin-polarized calculations of the adsorption and incorporation of iron in the Mn_3N_2(0 0 1) surfaces. By means of a surface formation energy criterion, it is demonstrated that Fe incorporation is energetically stable for all studied surfaces. An Fe bilayer formation is achieved after Fe atoms displace Mn atoms in the sub-surface N-vacancy layers. An analysis of the magnetic coupling shows an antiferromagnetic alignment along the [0 0 1] direction as in the clean, ideal surfaces. Also, the in-plane magnetic coupling between Fe–Fe and Fe–Mn shows a ferromagnetic tendency, similar to the clean, ideally terminated surfaces. These results clearly indicate that Fe behaves like Mn when adsorbed into the Mn_3N_2 surface. Density of states calculations of the stable structures show a slight deviation from the antiferromagnetic-like behavior, with the most important contribution around the Fermi level coming from the Fe-d and Mn-d orbitals.

  6. Understanding the stability of Fe incorporation within Mn{sub 3}N{sub 2}(0 0 1) surfaces: An ab-initio study

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero-Sánchez, J., E-mail: guerrero@ifuap.buap.mx [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570, México (Mexico); Centro de Nanociencias y Nanotecnologia, Universidad Nacional Autónoma de México, Apartado Postal 14, Ensenada, Baja California Codigo Postal 22800, México (Mexico); Mandru, Andrada-Oana [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Takeuchi, Noboru [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Centro de Nanociencias y Nanotecnologia, Universidad Nacional Autónoma de México, Apartado Postal 14, Ensenada, Baja California Codigo Postal 22800, México (Mexico); Cocoletzi, Gregorio H. [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570, México (Mexico); Smith, Arthur R. [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States)

    2016-02-15

    Graphical abstract: - Highlights: • The Fe incorporation into inner layers of the Mn{sub 3}N{sub 2} surfaces is stable in all range of chemical potential. • Displaced Mn atoms forming cluster-like structures induce the stability of incorporated Fe atoms. • Antiferromagnetic alignment in the [0 0 1] direction and in-plane Ferromagnetic Fe–Fe and Fe–Mn alignments are the same as in Mn{sub 3}N{sub 2} bulk structure. • Incorporated Fe layers contribute to the metallic character of these surfaces. - Abstract: We present first principles spin-polarized calculations of the adsorption and incorporation of iron in the Mn{sub 3}N{sub 2}(0 0 1) surfaces. By means of a surface formation energy criterion, it is demonstrated that Fe incorporation is energetically stable for all studied surfaces. An Fe bilayer formation is achieved after Fe atoms displace Mn atoms in the sub-surface N-vacancy layers. An analysis of the magnetic coupling shows an antiferromagnetic alignment along the [0 0 1] direction as in the clean, ideal surfaces. Also, the in-plane magnetic coupling between Fe–Fe and Fe–Mn shows a ferromagnetic tendency, similar to the clean, ideally terminated surfaces. These results clearly indicate that Fe behaves like Mn when adsorbed into the Mn{sub 3}N{sub 2} surface. Density of states calculations of the stable structures show a slight deviation from the antiferromagnetic-like behavior, with the most important contribution around the Fermi level coming from the Fe-d and Mn-d orbitals.

  7. Manganese Silylene Hydride Complexes: Synthesis and Reactivity with Ethylene to Afford Silene Hydride Complexes.

    Science.gov (United States)

    Price, Jeffrey S; Emslie, David J H; Britten, James F

    2017-05-22

    Reaction of the ethylene hydride complex trans-[(dmpe) 2 MnH(C 2 H 4 )] (1) with Et 2 SiH 2 at 20 °C afforded the silylene hydride [(dmpe) 2 MnH(=SiEt 2 )] (2 a) as the trans-isomer. By contrast, reaction of 1 with Ph 2 SiH 2 at 60 °C afforded [(dmpe) 2 MnH(=SiPh 2 )] (2 b) as a mixture of the cis (major) and trans (minor) isomers, featuring a Mn-H-Si interaction in the former. The reaction to form 2 b also yielded [(dmpe) 2 MnH 2 (SiHPh 2 )] (3 b); [(dmpe) 2 MnH 2 (SiHR 2 )] (R=Et (3 a) and Ph (3 b)) were accessed cleanly by reaction of 2 a and 2 b with H 2 , and the analogous reactions with D 2 afforded [(dmpe) 2 MnD 2 (SiHR 2 )] exclusively. Both 2 a and 2 b engaged in unique reactivity with ethylene, generating the silene hydride complexes cis-[(dmpe) 2 MnH(R 2 Si=CHMe)] (R=Et (4 a), Ph (4 b)). Compounds trans-2 a, cis-2 b, 3 b, and 4 b were crystallographically characterized, and bonding in 2 a, 2 b, 4 a, and 4 b was probed computationally. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Laser photoelectron spectroscopy of MnH - and FeH - : Electronic structures of the metal hydrides, identification of a low-spin excited state of MnH, and evidence for a low-spin ground state of FeH

    Science.gov (United States)

    Stevens, Amy E.; Feigerle, C. S.; Lineberger, W. C.

    1983-05-01

    The laser photoelectron spectra of MnH- and MnD-, and FeH- and FeD- are reported. A qualitative description of the electronic structure of the low-spin and high-spin states of the metal hydrides is developed, and used to interpret the spectra. A diagonal transition in the photodetachment to the known high-spin, 7Σ+, ground state of MnH is observed. An intense off-diagonal transition to a state of MnH, at 1725±50 cm-1 excitation energy, is attributed to loss of an antibonding electron from MnH-, to yield a low-spin quintet state of MnH. For FeH- the photodetachment to the ground state is an off-diagonal transition, attributed to loss of the antibonding electron from FeH-, to yield a low-spin quartet ground state of FeH. A diagonal transition results in an FeH state at 1945±55 cm-1; this state of FeH is assigned as the lowest-lying high-spin sextet state of FeH. An additional excited state of MnH and two other excited states of FeH are observed. Excitation energies for all the states are reported; vibrational frequencies and bond lengths for the ions and several states of the neutrals are also determined from the spectra. The electron affinity of MnH is found to be 0.869±0.010 eV; and the electron affinity of FeH is determined to be 0.934±0.011 eV. Spectroscopic constants for the various deuterides are also reported.

  9. Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange*

    Science.gov (United States)

    Borgogno, María V.; Monti, Mariela R.; Zhao, Weixing; Sung, Patrick; Argaraña, Carlos E.; Pezza, Roberto J.

    2016-01-01

    Recombination between homologous chromosomes is required for the faithful meiotic segregation of chromosomes and leads to the generation of genetic diversity. The conserved meiosis-specific Dmc1 recombinase catalyzes homologous recombination triggered by DNA double strand breaks through the exchange of parental DNA sequences. Although providing an efficient rate of DNA strand exchange between polymorphic alleles, Dmc1 must also guard against recombination between divergent sequences. How DNA mismatches affect Dmc1-mediated DNA strand exchange is not understood. We have used fluorescence resonance energy transfer to study the mechanism of Dmc1-mediated strand exchange between DNA oligonucleotides with different degrees of heterology. The efficiency of strand exchange is highly sensitive to the location, type, and distribution of mismatches. Mismatches near the 3′ end of the initiating DNA strand have a small effect, whereas most mismatches near the 5′ end impede strand exchange dramatically. The Hop2-Mnd1 protein complex stimulates Dmc1-catalyzed strand exchange on homologous DNA or containing a single mismatch. We observed that Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence. Our findings have important implications in understanding meiotic recombination. First, Dmc1 acts as an initial barrier for heterologous recombination, with the mismatch repair system providing a second level of proofreading, to ensure that ectopic sequences are not recombined. Second, Dmc1 stepping over infrequent mismatches is likely critical for allowing recombination between the polymorphic sequences of homologous chromosomes, thus contributing to gene conversion and genetic diversity. PMID:26709229

  10. Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange.

    Science.gov (United States)

    Borgogno, María V; Monti, Mariela R; Zhao, Weixing; Sung, Patrick; Argaraña, Carlos E; Pezza, Roberto J

    2016-03-04

    Recombination between homologous chromosomes is required for the faithful meiotic segregation of chromosomes and leads to the generation of genetic diversity. The conserved meiosis-specific Dmc1 recombinase catalyzes homologous recombination triggered by DNA double strand breaks through the exchange of parental DNA sequences. Although providing an efficient rate of DNA strand exchange between polymorphic alleles, Dmc1 must also guard against recombination between divergent sequences. How DNA mismatches affect Dmc1-mediated DNA strand exchange is not understood. We have used fluorescence resonance energy transfer to study the mechanism of Dmc1-mediated strand exchange between DNA oligonucleotides with different degrees of heterology. The efficiency of strand exchange is highly sensitive to the location, type, and distribution of mismatches. Mismatches near the 3' end of the initiating DNA strand have a small effect, whereas most mismatches near the 5' end impede strand exchange dramatically. The Hop2-Mnd1 protein complex stimulates Dmc1-catalyzed strand exchange on homologous DNA or containing a single mismatch. We observed that Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence. Our findings have important implications in understanding meiotic recombination. First, Dmc1 acts as an initial barrier for heterologous recombination, with the mismatch repair system providing a second level of proofreading, to ensure that ectopic sequences are not recombined. Second, Dmc1 stepping over infrequent mismatches is likely critical for allowing recombination between the polymorphic sequences of homologous chromosomes, thus contributing to gene conversion and genetic diversity. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Ab initio study of the structural, electronic, elastic and thermal properties of RMn{sub 2}Ge{sub 2} (R = Ca, Nd and Y) intermetallic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Miloud Abid, O.; Yakoubi, A. [Laboratoire d’Etudes des Matériaux et Instrumentations Expérimentales, Université Djilali Liabes de Sidi Bel-Abbes, 22000 (Algeria); Tadjer, A. [Modeling and Simulation in Materials Science Laboratory, Physics Department, University of Sidi Bel-Abbes, Sidi Bel-Abbes (Algeria); Khenata, R., E-mail: khenata_rabah@yahoo.fr [Laboratoire de Physique Quantique de la Modélisation Mathématique (LPQ3M), Université de Mascara, 29000 (Algeria); Ahmed, R. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, UTM Skudai, 81310 Johor (Malaysia); Murtaza, G. [Materials Modeling Laboratory, Department of Physics, Islamia College University, Peshawar (Pakistan); Bin Omran, S. [Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451 (Saudi Arabia); Azam, Sikander [New Technologies – Research Center, University of West Bohemia, Univerzitni 8, 306 14 Pilsen (Czech Republic)

    2014-12-15

    Highlights: • The calculated structural parameters of RMn{sub 2}Ge{sub 2} (R = Ca, Nd and Y) compounds are found in good agreement with the experimental data. • The structural and band structure calculation reveals that these compounds are ferromagnetic brittle metals. • The elastic and thermodynamic properties for the herein studied compounds are investigated for the first time. - Abstract: Intermetallic RMn{sub 2}Ge{sub 2} ternary compounds have attracted considerable attention from researchers in recent years because they show strong indications for novel magnetic characteristics and they have the potential to reveal the mechanism of superlattices. The study of the paramagnetic, ferromagnetic and antiferromagnetic phases affirms the strong dependence to the distance between atomic species in these compounds. In this study, we investigated the structural, elastic, electronic and thermodynamic properties of the intermetallic RMn{sub 2}Ge{sub 2} (R = Ca, Nd and Y) compounds. To carry out this study, we used the full potential (FP) linearized (L) augmented plane wave plus local orbitals (APW + lo), a scheme of calculations developed within the frame work of density functional theory (DFT). To incorporate the exchange correlation (XC) energy and corresponding potential into the total energy calculations, local density approximation (LDA) parameterized by Perdew and Wang is taken into account. Analysis of the density of states (DOS) profile illustrates the conducting nature of these intermetallic compounds; with a predominantly contribution from the R and Mn-d states. At ambient conditions, calculations for elastic constants (C{sub 11}, C{sub 12}, C{sub 13}, C{sub 44}, C{sub 33} and C{sub 66}) are also performed, which point to their brittle character. In addition, the quasi harmonic Debye model was used to predict the thermal properties, together with relative expansion coefficients and heat capacity.

  12. Ab-Initio Investigations of Magnetic Properties and Induced Half-Metallicity in Ga1-xMnxP (x = 0.03, 0.25, 0.5, and 0.75) Alloys.

    Science.gov (United States)

    Laref, Amel; AlMudlej, Abeer; Laref, Slimane; Yang, Jun Tao; Xiong, Yong-Chen; Luo, Shi Jun

    2017-07-07

    Ab-initio calculations are performed to examine the electronic structures and magnetic properties of spin-polarized Ga 1- x Mn x P ( x = 0.03, 0.25, 0.5, and 0.75) ternary alloys. In order to perceive viable half-metallic (HM) states and unprecedented diluted magnetic semiconductors (DMSs) such as spintronic materials, the full potential linearized augmented plane wave method is utilized within the generalized gradient approximation (GGA). In order to tackle the correlation effects on 3d states of Mn atoms, we also employ the Hubbard U (GGA + U) technique to compute the magnetic properties of an Mn-doped GaP compound. We discuss the emerged global magnetic moments and the robustness of half-metallicity by varying the Mn composition in the GaP compound. Using GGA + U, the results of the density of states demonstrate that the incorporation of Mn develops a half-metallic state in the GaP compound with an engendered band gap at the Fermi level ( E F ) in the spin-down state. Accordingly, the half-metallic feature is produced through the hybridization of Mn-d and P-p orbitals. However, the half-metallic character is present at a low x composition with the GGA procedure. The produced magnetic state occurs in these materials, which is a consequence of the exchange interactions between the Mn-element and the host GaP system. For the considered alloys, we estimated the X-ray absorption spectra at the K edge of Mn. A thorough clarification of the pre-edge peaks is provided via the results of the theoretical absorption spectra. It is inferred that the valence state of Mn in Ga 1- x Mn x P alloys is +3. The predicted theoretical determinations surmise that the Mn-incorporated GaP semiconductor could inevitably be employed in spintronic devices.

  13. Ab-Initio Investigations of Magnetic Properties and Induced Half-Metallicity in Ga1−xMnxP (x = 0.03, 0.25, 0.5, and 0.75 Alloys

    Directory of Open Access Journals (Sweden)

    Amel Laref

    2017-07-01

    Full Text Available Ab-initio calculations are performed to examine the electronic structures and magnetic properties of spin-polarized Ga1−xMnxP (x = 0.03, 0.25, 0.5, and 0.75 ternary alloys. In order to perceive viable half-metallic (HM states and unprecedented diluted magnetic semiconductors (DMSs such as spintronic materials, the full potential linearized augmented plane wave method is utilized within the generalized gradient approximation (GGA. In order to tackle the correlation effects on 3d states of Mn atoms, we also employ the Hubbard U (GGA + U technique to compute the magnetic properties of an Mn-doped GaP compound. We discuss the emerged global magnetic moments and the robustness of half-metallicity by varying the Mn composition in the GaP compound. Using GGA + U, the results of the density of states demonstrate that the incorporation of Mn develops a half-metallic state in the GaP compound with an engendered band gap at the Fermi level (EF in the spin–down state. Accordingly, the half-metallic feature is produced through the hybridization of Mn-d and P-p orbitals. However, the half-metallic character is present at a low x composition with the GGA procedure. The produced magnetic state occurs in these materials, which is a consequence of the exchange interactions between the Mn-element and the host GaP system. For the considered alloys, we estimated the X-ray absorption spectra at the K edge of Mn. A thorough clarification of the pre-edge peaks is provided via the results of the theoretical absorption spectra. It is inferred that the valence state of Mn in Ga1−xMnxP alloys is +3. The predicted theoretical determinations surmise that the Mn-incorporated GaP semiconductor could inevitably be employed in spintronic devices.

  14. First-principles calculations of the magnetic properties of (Cd,Mn)Te nanocrystals

    Science.gov (United States)

    Echeverría-Arrondo, C.; Pérez-Conde, J.; Ayuela, A.

    2009-04-01

    We investigate the electronic and magnetic properties of Mn-doped CdTe nanocrystals (NCs) with ˜2nm in diameter which can be experimentally synthesized with Mn atoms inside. Using the density-functional theory, we consider two doping cases: NCs containing one or two Mn impurities. Although the Mnd peaks carry five up electrons in the dot, the local magnetic moment on the Mn site is 4.65μB . It is smaller than 5μB because of the sp-d hybridization between the localized 3d electrons of the Mn atoms and the s - and p -type valence states of the host compound. The sp-d hybridization induces small magnetic moments on the Mn-nearest-neighbor Te sites, antiparallel to the Mn moment affecting the p -type valence states of the undoped dot, as usual for a kinetic-mediated exchange magnetic coupling. Furthermore, we calculate the parameters standing for the sp-d exchange interactions. Conduction N0α and valence N0β are close to the experimental bulk values when the Mn impurities occupy bulklike NCs’ central positions, and they tend to zero close to the surface. This behavior is further explained by an analysis of valence-band-edge states showing that symmetry breaking splits the states and in consequence reduces the exchange. For two Mn atoms in several positions, the valence edge states show a further departure from an interpretation based in a perturbative treatment. We also calculate the d-d exchange interactions |Jdd| between Mn spins. The largest |Jdd| value is also for Mn atoms on bulklike central sites; in comparison with the experimental d-d exchange constant in bulk Cd0.95Mn0.05Te , it is four times smaller.

  15. The effect of ventilatory muscle training on respiratory function and capacity in ambulatory and bed-ridden patients with neuromuscular disease.

    Science.gov (United States)

    Gross, D; Meiner, Z

    1993-08-01

    Most patients with neuromuscular disease develop muscle weakness, including the ventilatory muscles leading to respiratory difficulty and, at times, respiratory insufficiency. We studied the effect of ventilatory muscle training on the ventilatory function and capacity of patients with various types of neuromuscular disease. The ambulatory patients were divided into three major groups. Group I (n = 6) patients with motor neuron disease (MND), such as amyotrophic latera sclerosis; Group II (n = 11) patients with myoneural junction disease (MNJ), such as myasthenia gravis and: Group III (n = 7) patients with muscle diseases such as progressive muscular disease. Patients were evaluated for their neuromuscular diagnosis and status of the disease. A complete physical examination and the various neuromuscular tests were performed. A complete respiratory evaluation was applied: pulmonary function tests (PFT), maximum inspiratory pressure (MIP). Patients then started ventilatory muscle training by resistive breathing, as a prophylactic treatment, for 10 min, three times daily, with a resistance which would induce fatigue. All tests were repeated every six weeks, and the results were as follow: forced vital capacity (FVC) changed from 38.8 +/- 12.3 to 53.2 +/- 9.6% (NS) of predicted value in group I, from 49.8 +/- 8.7 to 66.1 +/- 7.5% (p < 0.002) in group II, and from 47.0 +/- 7.5 to 53.3 +/- 7.6% (p < 0.04) in group III. Forced expiratory volume in one second (FEV1) was 34.8 +/- 11.0, 46.3 +/- 5, and 45.1 +/- 9% for the three groups, respectively, and did not change with training.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. The extracellular domain of neurotrophin receptor p75 as a candidate biomarker for amyotrophic lateral sclerosis.

    Directory of Open Access Journals (Sweden)

    Stephanie R Shepheard

    Full Text Available Objective biomarkers for amyotrophic lateral sclerosis would facilitate the discovery of new treatments. The common neurotrophin receptor p75 is up regulated and the extracellular domain cleaved from injured neurons and peripheral glia in amyotrophic lateral sclerosis. We have tested the hypothesis that urinary levels of extracellular neurotrophin receptor p75 serve as a biomarker for both human motor amyotrophic lateral sclerosis and the SOD1(G93A mouse model of the disease. The extracellular domain of neurotrophin receptor p75 was identified in the urine of amyotrophic lateral sclerosis patients by an immuno-precipitation/western blot procedure and confirmed by mass spectrometry. An ELISA was established to measure urinary extracellular neurotrophin receptor p75. The mean value for urinary extracellular neurotrophin receptor p75 from 28 amyotrophic lateral sclerosis patients measured by ELISA was 7.9±0.5 ng/mg creatinine and this was significantly higher (p<0.001 than 12 controls (2.6±0.2 ng/mg creatinine and 19 patients with other neurological disease (Parkinson's disease and Multiple Sclerosis; 4.1±0.2 ng/mg creatinine. Pilot data of disease progression rates in 14 MND patients indicates that p75NTR(ECD levels were significantly higher (p = 0.0041 in 7 rapidly progressing patients as compared to 7 with slowly progressing disease. Extracellular neurotrophin receptor p75 was also readily detected in SOD1(G93A mice by immuno-precipitation/western blot before the onset of clinical symptoms. These findings indicate a significant relation between urinary extracellular neurotrophin receptor p75 levels and disease progression and suggests that it may be a useful marker of disease activity and progression in amyotrophic lateral sclerosis.

  17. Dynamic propagation and cleavage crack arrest in bainitic steel

    International Nuclear Information System (INIS)

    Hajjaj, M.

    2006-06-01

    In complement of the studies of harmfulness of defects, generally realized in term of initiation, the concept of crack arrest could be used as complementary analyses to the studies of safety. The stop occurs when the stress intensity factor becomes lower than crack arrest toughness (KIa) calculated in elasto-statics (KI ≤ KIa). The aim of this thesis is to understand and predict the stop of a crack propagating at high speed in a 18MND5 steel used in the pressure water reactor (PWR). The test chosen to study crack arrest is the disc thermal shock test. The observations under the scanning electron microscope of the fracture surface showed that the crack arrest always occurs in cleavage mode and that the critical microstructural entity with respect to the propagation and crack arrest corresponds to at least the size of the prior austenitic grain. The numerical analyses in elasto-statics confirm the conservatism of the codified curve of the RCC-M with respect to the values of KIa. The dynamic numerical analyses show that the deceleration of the crack measured at the end of the propagation is related to the global dynamic of the structure (vibrations). The transferability to components of crack arrest toughness obtained from tests analysed in static is thus not assured. The disc thermal shock tests were also modelled by considering a criterion of propagation and arrest of the type 'RKR' characterized by a critical stress sc which depends on the temperature. The results obtained account well for the crack jump measured in experiments as well as the shape of the crack arrest front. (author)

  18. FEM-calculation of different creep-tests with French and German RPV-steels

    International Nuclear Information System (INIS)

    Willschuetz, H.-G.; Altstadt, E.; Weiss, F.-P.; Sehgal, B.R.

    2003-01-01

    For calculations of Lower Head Failure experiments like FOREVER it is necessary to model creep and plasticity processes. Therefore a Finite Element Model is developed using a numerical approach which avoids the use of a single creep law employing constants derived from the data for a limited stress and temperature range. Instead of this a numerical creep data base (CDB) is developed where the creep strain rate is evaluated in dependence on the current total strain, temperature and equivalent stress. A main task for this approach is the generation and validation of the CDB. For an evaluation of the failure times a damage model according to an approach of Lemaitre is applied. The validation of the numerical model is performed by the simulation of and comparison with experiments. This is done in 3 levels: starting with the simulation of single uniaxial creep tests, which is considered as a 1D-problem. In the next level so called 'tube-failure-experiments' are modeled: the RUPTHER-14 and the 'MPA-Meppen'- experiment. These experiments are considered as 2D-problems. Finally the numerical model is applied to scaled 3D experiments, where the lower head of a PWR is represented in its hemispherical shape, like in the FOREVER experiments. An interesting question to be solved in this frame is the comparability of the French 16MND5 and the German 20MnMoNi55 RPV-steels, which are chemically nearly identical. If these 2 steels show a similar behavior, it should be allowed to transfer experimental and numerical data from one to the other. (author)

  19. The neuropathology of sport.

    Science.gov (United States)

    McKee, Ann C; Daneshvar, Daniel H; Alvarez, Victor E; Stein, Thor D

    2014-01-01

    The benefits of regular exercise, physical fitness and sports participation on cardiovascular and brain health are undeniable. Physical activity reduces the risk for cardiovascular disease, type 2 diabetes, hypertension, obesity, and stroke, and produces beneficial effects on cholesterol levels, antioxidant systems, inflammation, and vascular function. Exercise also enhances psychological health, reduces age-related loss of brain volume, improves cognition, reduces the risk of developing dementia, and impedes neurodegeneration. Nonetheless, the play of sports is associated with risks, including a risk for mild TBI (mTBI) and, rarely, catastrophic traumatic injury and death. There is also growing awareness that repetitive mTBIs, such as concussion and subconcussion, can occasionally produce persistent cognitive, behavioral, and psychiatric problems as well as lead to the development of a neurodegeneration, chronic traumatic encephalopathy (CTE). In this review, we summarize the beneficial aspects of sports participation on psychological, emotional, physical and cognitive health, and specifically analyze some of the less common adverse neuropathological outcomes, including concussion, second-impact syndrome, juvenile head trauma syndrome, catastrophic sudden death, and CTE. CTE is a latent neurodegeneration clinically associated with behavioral changes, executive dysfunction and cognitive impairments, and pathologically characterized by frontal and temporal lobe atrophy, neuronal and axonal loss, and abnormal deposits of paired helical filament (PHF)-tau and 43 kDa TAR deoxyribonucleic acid (DNA)-binding protein (TDP-43). CTE often occurs as a sole diagnosis, but may be associated with other neurodegenerative disorders, including motor neuron disease (CTE-MND). Although the incidence and prevalence of CTE are not known, CTE has been reported most frequently in American football players and boxers. Other sports associated with CTE include ice hockey, professional

  20. Variation in the mineral element concentration of Moringa oleifera Lam. and M. stenopetala (Bak. f.) Cuf.: Role in human nutrition.

    Science.gov (United States)

    Kumssa, Diriba B; Joy, Edward Jm; Young, Scott D; Odee, David W; Ander, E Louise; Broadley, Martin R

    2017-01-01

    Moringa oleifera (MO) and M. stenopetala (MS) (family Moringaceae; order Brassicales) are multipurpose tree/shrub species. They thrive under marginal environmental conditions and produce nutritious edible parts. The aim of this study was to determine the mineral composition of different parts of MO and MS growing in their natural environments and their potential role in alleviating human mineral micronutrient deficiencies (MND) in sub-Saharan Africa. Edible parts of MO (n = 146) and MS (n = 50), co-occurring cereals/vegetables and soils (n = 95) underneath their canopy were sampled from localities in southern Ethiopia and Kenya. The concentrations of seven mineral elements, namely, calcium (Ca), copper (Cu), iodine (I), iron (Fe), magnesium (Mg), selenium (Se), and zinc (Zn) in edible parts and soils were determined using inductively coupled plasma-mass spectrometry. In Ethiopian crops, MS leaves contained the highest median concentrations of all elements except Cu and Zn, which were greater in Enset (a.k.a., false banana). In Kenya, Mo flowers and MS leaves had the highest median Se concentration of 1.56 mg kg-1 and 3.96 mg kg-1, respectively. The median concentration of Se in MS leaves was 7-fold, 10-fold, 23-fold, 117-fold and 147-fold more than that in brassica leaves, amaranth leaves, baobab fruits, sorghum grain and maize grain, respectively. The median Se concentration was 78-fold and 98-fold greater in MO seeds than in sorghum and maize grain, respectively. There was a strong relationship between soil total Se and potassium dihydrogen phosphate (KH2PO4)-extractable Se, and Se concentration in the leaves of MO and MS. This study confirms previous studies that Moringa is a good source of several of the measured mineral nutrients, and it includes the first wide assessment of Se and I concentrations in edible parts of MO and MS grown in various localities. Increasing the consumption of MO and MS, especially the leaves as a fresh vegetable or in powdered form

  1. Development, effectiveness and cost-effectiveness of a new out-patient Breathlessness Support Service: study protocol of a phase III fast-track randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Bausewein Claudia

    2012-09-01

    Full Text Available Abstract Background Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim to provide comprehensive care for patients and their carers by a multiprofessional team but their effectiveness and cost-effectiveness have not yet been proven. The Breathlessness Support Service (BSS is a newly created multiprofessional and interdisciplinary outpatient service at a large university hospital in South East London. The aim of this study is to develop and evaluate the effectiveness and cost effectiveness of this multidisciplinary out–patient BSS for the palliation of breathlessness, in advanced malignant and non-malignant disease. Methods The BSS was modelled based on the results of qualitative and quantitative studies, and systematic literature reviews. A randomised controlled fast track trial (RCT comprising two groups: 1 intervention (immediate access to BSS in addition to standard care; 2 control group (standard best practice and access to BSS after a waiting time of six weeks. Patients are included if suffering from breathlessness on exertion or at rest due to advanced disease such as cancer, chronic obstructive pulmonary disease (COPD, chronic heart failure (CHF, interstitial lung disease (ILD or motor neurone disease (MND that is refractory to maximal optimised medical management. Both quantitative and qualitative outcomes are assessed in face to-face interviews at baseline, after 6 and 12 weeks. The primary outcome is patients' improvement of mastery of breathlessness after six weeks assessed on the Chronic Respiratory Disease Questionnaire (CRQ. Secondary outcomes for patients include breathlessness severity, symptom burden, palliative care needs, service use, and respiratory measures (spirometry

  2. In-vessel retention after relocation of corium into the lower plenum. Summary of the current project results. Technical report

    International Nuclear Information System (INIS)

    Altstadt, E.; Willschuetz, H.G.

    2003-03-01

    3D-experiments, where the lower head of a PWR is represented in its hemispherical shape, like in the FOREVER-experiments. In cooperation with the experimentators at the KTH in Stockholm pre- and post-test calculations of these unique experiments have been performed. The results are qualitatively and quantitatively quite satisfactory. An interesting question to be solved in this frame is the comparability of the French 16MND5 and the German 20MnMoNi5-5 RPV-steels, which are chemically nearly identical. Since these 2 steels show a similar behavior, it should be allowed on a limited scale to transfer experimental and numerical data from one to the other. (orig.)

  3. Simulation of creep tests with French or German RPV-steel and investigation of a RPV-support against failure

    International Nuclear Information System (INIS)

    Willschuetz, H.-G.; Altstadt, E.; Sehgal, B.R.; Weiss, F.-P.

    2003-01-01

    Investigating the hypothetical core melt down scenario for a light water reactor (LWR) a possible failure mode of the reactor pressure vessel (RPV) and its failure time has to be considered for a determination of the loadings on the containment. For pre- and post-test calculations of Lower Head Failure experiments like OLHF or FOREVER it is necessary to model creep and plasticity processes. Therefore a Finite Element Model is developed at the FZR using a numerical approach which avoids the use of a single creep law employing constants derived from the data for a limited stress and temperature range. Instead of this a numerical creep data base (CDB) is developed in which the creep strain rate is evaluated in dependence on the current total strain, temperature and equivalent stress. A main task for this approach is the generation and validation of the CDB. Additionally the implementation of all relevant temperature dependent material properties is performed. For the consideration of the tertiary creep stage and for the evaluation of the failure times a damage model according to an approach of Lemaitre is applied. The validation of the numerical model is performed by the simulation of and comparison with experiments. This is done in three levels: starting with the simulation of single uniaxial creep tests, which is considered as a 1D-problem. In the next level so called 'tube-failure-experiments' are modeled: the RUPTHER-14 and the 'MPA-Meppen'-experiment. These experiments are considered as 2D-problems. Finally the numerical model is applied to scaled 3D-experiments, where the lower head of a PWR is represented in its hemispherical shape, like in the FOREVER-experiments. An interesting question to be solved in this frame is the comparability of the French 16MND5 and the German 20MnMoNi5-5 RPV-steels, which are chemically nearly identical. Since these two steels show a similar behavior, it should be allowed to a limited extend to transfer experimental and numerical

  4. Frontotemporal dementia and its subtypes: a genome-wide association study

    Science.gov (United States)

    Ferrari, Raffaele; Hernandez, Dena G; Nalls, Michael A; Rohrer, Jonathan D; Ramasamy, Adaikalavan; Kwok, John B J; Dobson-Stone, Carol; Brooks, William S; Schofield, Peter R; Halliday, Glenda M; Hodges, John R; Piguet, Olivier; Bartley, Lauren; Thompson, Elizabeth; Haan, Eric; Hernández, Isabel; Ruiz, Agustín; Boada, Mercè; Borroni, Barbara; Padovani, Alessandro; Cruchaga, Carlos; Cairns, Nigel J; Benussi, Luisa; Binetti, Giuliano; Ghidoni, Roberta; Forloni, Gianluigi; Galimberti, Daniela; Fenoglio, Chiara; Serpente, Maria; Scarpini, Elio; Clarimón, Jordi; Lleó, Alberto; Blesa, Rafael; Waldö, Maria Landqvist; Nilsson, Karin; Nilsson, Christer; Mackenzie, Ian R A; Hsiung, Ging-Yuek R; Mann, David M A; Grafman, Jordan; Morris, Christopher M; Attems, Johannes; Griffiths, Timothy D; McKeith, Ian G; Thomas, Alan J; Pietrini, P; Huey, Edward D; Wassermann, Eric M; Baborie, Atik; Jaros, Evelyn; Tierney, Michael C; Pastor, Pau; Razquin, Cristina; Ortega-Cubero, Sara; Alonso, Elena; Perneczky, Robert; Diehl-Schmid, Janine; Alexopoulos, Panagiotis; Kurz, Alexander; Rainero, Innocenzo; Rubino, Elisa; Pinessi, Lorenzo; Rogaeva, Ekaterina; George-Hyslop, Peter St; Rossi, Giacomina; Tagliavini, Fabrizio; Giaccone, Giorgio; Rowe, James B; Schlachetzki, J C M; Uphill, James; Collinge, John; Mead, S; Danek, Adrian; Van Deerlin, Vivianna M; Grossman, Murray; Trojanowsk, John Q; van der Zee, Julie; Deschamps, William; Van Langenhove, Tim; Cruts, Marc; Van Broeckhoven, Christine; Cappa, Stefano F; Le Ber, Isabelle; Hannequin, Didier; Golfier, Véronique; Vercelletto, Martine; Brice, Alexis; Nacmias, Benedetta; Sorbi, Sandro; Bagnoli, Silvia; Piaceri, Irene; Nielsen, Jørgen E; Hjermind, Lena E; Riemenschneider, Matthias; Mayhaus, Manuel; Ibach, Bernd; Gasparoni, Gilles; Pichler, Sabrina; Gu, Wei; Rossor, Martin N; Fox, Nick C; Warren, Jason D; Spillantini, Maria Grazia; Morris, Huw R; Rizzu, Patrizia; Heutink, Peter; Snowden, Julie S; Rollinson, Sara; Richardson, Anna; Gerhard, Alexander; Bruni, Amalia C; Maletta, Raffaele; Frangipane, Francesca; Cupidi, Chiara; Bernardi, Livia; Anfossi, Maria; Gallo, Maura; Conidi, Maria Elena; Smirne, Nicoletta; Rademakers, Rosa; Baker, Matt; Dickson, Dennis W; Graff-Radford, Neill R; Petersen, Ronald C; Knopman, David; Josephs, Keith A; Boeve, Bradley F; Parisi, Joseph E; Seeley, William W; Miller, Bruce L; Karydas, Anna M; Rosen, Howard; van Swieten, John C; Dopper, Elise G P; Seelaar, Harro; Pijnenburg, Yolande AL; Scheltens, Philip; Logroscino, Giancarlo; Capozzo, Rosa; Novelli, Valeria; Puca, Annibale A; Franceschi, M; Postiglione, Alfredo; Milan, Graziella; Sorrentino, Paolo; Kristiansen, Mark; Chiang, Huei-Hsin; Graff, Caroline; Pasquier, Florence; Rollin, Adeline; Deramecourt, Vincent; Lebert, Florence; Kapogiannis, Dimitrios; Ferrucci, Luigi; Pickering-Brown, Stuart; Singleton, Andrew B; Hardy, John; Momeni, Parastoo

    2014-01-01

    Summary Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes—MAPT, GRN, and C9orf72—have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. Methods We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. All participants had European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10−8) and suggestive single-nucleotide polymorphisms. Findings We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10−8) that encompassed the HLA locus at 6p21.3 in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC, for the behavioural FTD subtype. Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation incis. Interpretation Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and possibly to shed light on the pathomechanisms contributing to FTD. Funding The National Institute of

  5. Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31].

    Science.gov (United States)

    Al-Chalabi, Ammar; Shaw, Pamela J; Young, Carolyn A; Morrison, Karen E; Murphy, Caroline; Thornhill, Marie; Kelly, Joanna; Steen, I Nicholas; Leigh, P Nigel

    2011-09-21

    Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate on survival. 44 patients were studied, with 16 randomly selected to take LiCO3 and riluzole and 28 allocated to take riluzole alone. In the group treated with lithium, no patients had died (i.e., 100% survival) at the end of the study (15 months from entry), compared to 71% surviving in the riluzole-only group. Although the trial can be criticised on several grounds, there is a substantial rationale from other laboratory studies that lithium is worth investigating therapeutically in amyotrophic lateral sclerosis. LiCALS is a multi-centre double-blind randomised parallel group controlled trial of the efficacy, safety, and tolerability of lithium carbonate (LiCO3) at doses to achieve stable 'therapeutic' plasma levels (0.4-0.8 mmol/L), plus standard treatment, versus matched placebo plus standard treatment, in patients with amyotrophic lateral sclerosis. The study will be based in the UK, in partnership with the MND Association and DeNDRoN (the Dementias and Neurodegnerative Diseases Clinical Research Network). 220 patients will be recruited. All patients will be on the standard treatment for ALS of riluzole 100 mg daily. The primary outcome measure will be death from any cause at 18 months defined from the date of randomisation. Secondary outcome measures will be changes in three functional rating scales, the ALS Functional Rating Scale-Revised, The EuroQOL (EQ-5D), and the Hospital Anxiety and Depression Scale.Eligible patients will have El Escorial Possible, Laboratory-supported Probable, Probable or Definite amyotrophic lateral sclerosis with disease duration between 6 months and 36 months (inclusive), vital capacity ≥ 60% of predicted within 1 month prior to

  6. Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic Lateral Sclerosis (LiCALS [Eudract number: 2008-006891-31

    Directory of Open Access Journals (Sweden)

    Kelly Joanna

    2011-09-01

    Full Text Available Abstract Background Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate on survival. 44 patients were studied, with 16 randomly selected to take LiCO3 and riluzole and 28 allocated to take riluzole alone. In the group treated with lithium, no patients had died (i.e., 100% survival at the end of the study (15 months from entry, compared to 71% surviving in the riluzole-only group. Although the trial can be criticised on several grounds, there is a substantial rationale from other laboratory studies that lithium is worth investigating therapeutically in amyotrophic lateral sclerosis. Methods/Design LiCALS is a multi-centre double-blind randomised parallel group controlled trial of the efficacy, safety, and tolerability of lithium carbonate (LiCO3 at doses to achieve stable 'therapeutic' plasma levels (0.4-0.8 mmol/L, plus standard treatment, versus matched placebo plus standard treatment, in patients with amyotrophic lateral sclerosis. The study will be based in the UK, in partnership with the MND Association and DeNDRoN (the Dementias and Neurodegnerative Diseases Clinical Research Network. 220 patients will be recruited. All patients will be on the standard treatment for ALS of riluzole 100 mg daily. The primary outcome measure will be death from any cause at 18 months defined from the date of randomisation. Secondary outcome measures will be changes in three functional rating scales, the ALS Functional Rating Scale-Revised, The EuroQOL (EQ-5D, and the Hospital Anxiety and Depression Scale. Eligible patients will have El Escorial Possible, Laboratory-supported Probable, Probable or Definite amyotrophic lateral sclerosis with disease duration between 6 months and 36 months (inclusive, vital

  7. Mechanical and thermal resistance of multi-material components for ITER

    International Nuclear Information System (INIS)

    Burlet, H.

    2013-01-01

    . It may be used for various applications such as test blanket module and divertor. It is also envisaged in PWR fission reactors, for instance to join 316 stainless steel onto 16MND5. (authors)

  8. Generation of a high temperature material data base and its application to creep tests with French or German RPV-steel. Technical report

    International Nuclear Information System (INIS)

    Willschuetz, H.G.; Altstadt, E.

    2002-08-01

    Considering the hypothetical core melt down scenario for a light water reactor (LWR) a possible failure mode of the reactor pressure vessel (RPV) and its failure time has to be investigated for a determination of the loadings on the containment. Numerous experiments have been performed accompanied with material properties evaluation, theoretical, and numerical work /REM 1993/, /THF 1997/, /CHU 1999/. For pre- and post-test calculations of Lower Head Failure experiments like OLHF or FOREVER it is necessary to model creep and plasticity processes. Therefore a Finite Element Model is developed at the FZR using a numerical approach which avoids the use of a single creep law employing constants derived from the data for a limited stress and temperature range. Instead of this a numerical creep data base (CDB) is developed where the creep strain rate is evaluated in dependence on the current total strain, temperature and equivalent stress. A main task for this approach is the generation and validation of the CDB. Additionally the implementation of all relevant temperature dependent material properties has been performed. For an evaluation of the failure times a damage model according to an approach of Lemaitre is applied. The validation of the numerical model is performed by the simulation of and comparison with experiments. This is done in 3 levels: starting with the simulation of single uniaxial creep tests, which is considered as a 1D-problem. In the next level so called ''tube-failure-experiments'' are modeled: the RUPTHER-14 and the ''MPA-Meppen''-experiment. These experiments are considered as 2D-problems. Finally the numerical model is applied to scaled 3D-experiments, where the lower head of a PWR is represented in its hemispherical shape, like in the FOREVER-experiments. This report deals with the 1D- and 2D-simulations. An interesting question to be solved in this frame is the comparability of the French 16MND5 and the German 20MnMoNi55 RPV-steels, which are

  9. Final Technical Report for Project 'Improving the Simulation of Arctic Clouds in CCSM3 (SGER Award)'

    International Nuclear Information System (INIS)

    Vavrus, Stephen J.

    2008-01-01

    clouds in the modern climate. This site was used extensively in the IARC summer school projects. This work has also led to a collaboration this year during a 4-month visit I made to NCAR through its Faculty Fellowship Program. I worked with scientists Marika Holland, David Bailey, Andrew Gettleman, and Jen Kay, who are researching polar climate and/or clouds. I met with this group frequently during my visit, leading to some fruitful interactions. This work led to the discovery of a tightly coupled response of clouds and sea ice during intervals of rapid sea ice loss in greenhouse simulations, as well as advising on the evolving CCSM3.5 to CCSM4 model development. This involvement with NCAR also led to a longer-term connection, as I have recently begun a two-year stint on the SSC for CCSM.

  10. Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

    Science.gov (United States)

    Ludolph, Albert C; Schuster, Joachim; Dorst, Johannes; Dupuis, Luc; Dreyhaupt, Jens; Weishaupt, Jochen H; Kassubek, Jan; Weiland, Ulrike; Petri, Susanne; Meyer, Thomas; Grosskreutz, Julian; Schrank, Berthold; Boentert, Matthias; Emmer, Alexander; Hermann, Andreas; Zeller, Daniel; Prudlo, Johannes; Winkler, Andrea S; Grehl, Torsten; Heneka, Michael T; Wollebæk Johannesen, Siw; Göricke, Bettina

    2018-06-18

    Rasagiline, a monoamine oxidase B inhibitor with neuroprotective potential in Parkinson's disease, has shown a disease-modifying effect in the SOD1-Gly93Ala low-expressing mouse model of amyotrophic lateral sclerosis, both alone and in combination with riluzole. We sought to test whether or not rasagiline 1 mg/day can prolong survival in patients with amyotrophic lateral sclerosis also receiving riluzole. Patients with possible, probable, or definite amyotrophic lateral sclerosis were enrolled to our randomised, placebo-controlled, parallel-group, double-blind, phase 2 trial from 15 German network for motor neuron diseases (MND-NET) centres (university hospitals or clinics). Eligible patients were aged at least 18 years, had onset of progressive weakness within the 36 months before the study, had disease duration of more than 6 months and less than 3 years, and had a best-sitting slow vital capacity of at least 50%. After a 4-week screening period, eligible patients were randomly assigned (1:1) to receive either rasagiline (1 mg/day) or placebo in addition to riluzole (100 mg/day), after stratification for site of onset (bulbar or spinal) and study centre. Patients and all personnel assessing outcome parameters were masked to treatment allocation. Patients were followed up 2, 6, 12, and 18 months after randomisation. The primary endpoint was survival time, defined as the time to death or time to study cutoff date (ie, the last patient's last visit plus 14 days). Analyses of primary outcome and safety measures were done in all patients who received at least one dose of trial treatment (intention-to-treat population). The trial is registered with ClinicalTrials.gov, number NCT01879241. Between July 2, 2013, and Nov 11, 2014, 273 patients were screened for eligibility, and 252 patients were randomly assigned to receive rasagiline (n=127) or placebo (n=125). 126 patients taking rasagiline and 125 taking placebo were included in the intention-to-treat analysis. For the

  11. X-linked spinal and bulbar muscular atrophy (Kennedy's disease with long-term electrophysiological evaluation: case report Atrofia muscular bulbo-espinal ligada ao cromossomo X (doença de Kennedy com seguimento eletrofisiológico de longo prazo: relato de caso

    Directory of Open Access Journals (Sweden)

    João Aris Kouyoumdjian

    2005-03-01

    Full Text Available X-linked spinal and bulbar muscular atrophy or Kennedy's disease is an adult-onset motor neuronopathy caused by a CAG repeat expansion within the first exon of an androgen receptor gene. We report the case of a 66-year-old man, previously diagnosed with motor neuron disease (MND, who presented acute and reversible left vocal fold (dysphonia and pharyngeal paresis, followed by a slowly progressive weakness and also bouts of weakness, wasting and fasciculation on tongue, masseter, face, pharyngeal, and some proximal more than distal upper limb muscles, associated to bilateral hand tremor and mild gynecomastia. There were 5 electroneuromyography exams between 1989 and 2003 that revealed chronic reinnervation, some fasciculations (less than clinically observed and rare fibrillation potentials, and slowly progressive sensory nerve action potentials (SNAP abnormality, leading to absent/low amplitude potentials. PCR techniques of DNA analysis showed an abnormal number of CAG repeats, found to be 44 (normal 11-34. Our case revealed an acute and asymmetric clinical presentation related to bulbar motoneurons; low amplitude/absent SNAP with mild asymmetry; a sub-clinical or subtle involvement of proximal/distal muscles of both upper and lower limbs; and a probable evolution with bouts of acute dennervation, followed by an efficient reinnervation.Atrofia muscular bulbo-espinal ligada ao cromossomo X (doença de Kennedy é uma neuronopatia motora em adultos causada por expansões na repetição CAG no gene do receptor andrógeno. Neste relato, descreve-se o caso de homem de 66 anos, com diagnóstico prévio de doença do neurônio motor (DNM que apresentou quadro agudo e reversível de paresia de prega vocal (disfonia e de músculos faríngeos à esquerda; posteriormente seguiram-se surtos de fraqueza lentamente progressiva, atrofia e fasciculações em língua, masseter, face, faringe e membros superiores predominantemente proximal, associada a tremor

  12. Frontotemporal dementia and its subtypes: a genome-wide association study.

    Science.gov (United States)

    Ferrari, Raffaele; Hernandez, Dena G; Nalls, Michael A; Rohrer, Jonathan D; Ramasamy, Adaikalavan; Kwok, John B J; Dobson-Stone, Carol; Brooks, William S; Schofield, Peter R; Halliday, Glenda M; Hodges, John R; Piguet, Olivier; Bartley, Lauren; Thompson, Elizabeth; Haan, Eric; Hernández, Isabel; Ruiz, Agustín; Boada, Mercè; Borroni, Barbara; Padovani, Alessandro; Cruchaga, Carlos; Cairns, Nigel J; Benussi, Luisa; Binetti, Giuliano; Ghidoni, Roberta; Forloni, Gianluigi; Galimberti, Daniela; Fenoglio, Chiara; Serpente, Maria; Scarpini, Elio; Clarimón, Jordi; Lleó, Alberto; Blesa, Rafael; Waldö, Maria Landqvist; Nilsson, Karin; Nilsson, Christer; Mackenzie, Ian R A; Hsiung, Ging-Yuek R; Mann, David M A; Grafman, Jordan; Morris, Christopher M; Attems, Johannes; Griffiths, Timothy D; McKeith, Ian G; Thomas, Alan J; Pietrini, P; Huey, Edward D; Wassermann, Eric M; Baborie, Atik; Jaros, Evelyn; Tierney, Michael C; Pastor, Pau; Razquin, Cristina; Ortega-Cubero, Sara; Alonso, Elena; Perneczky, Robert; Diehl-Schmid, Janine; Alexopoulos, Panagiotis; Kurz, Alexander; Rainero, Innocenzo; Rubino, Elisa; Pinessi, Lorenzo; Rogaeva, Ekaterina; St George-Hyslop, Peter; Rossi, Giacomina; Tagliavini, Fabrizio; Giaccone, Giorgio; Rowe, James B; Schlachetzki, Johannes C M; Uphill, James; Collinge, John; Mead, Simon; Danek, Adrian; Van Deerlin, Vivianna M; Grossman, Murray; Trojanowski, John Q; van der Zee, Julie; Deschamps, William; Van Langenhove, Tim; Cruts, Marc; Van Broeckhoven, Christine; Cappa, Stefano F; Le Ber, Isabelle; Hannequin, Didier; Golfier, Véronique; Vercelletto, Martine; Brice, Alexis; Nacmias, Benedetta; Sorbi, Sandro; Bagnoli, Silvia; Piaceri, Irene; Nielsen, Jørgen E; Hjermind, Lena E; Riemenschneider, Matthias; Mayhaus, Manuel; Ibach, Bernd; Gasparoni, Gilles; Pichler, Sabrina; Gu, Wei; Rossor, Martin N; Fox, Nick C; Warren, Jason D; Spillantini, Maria Grazia; Morris, Huw R; Rizzu, Patrizia; Heutink, Peter; Snowden, Julie S; Rollinson, Sara; Richardson, Anna; Gerhard, Alexander; Bruni, Amalia C; Maletta, Raffaele; Frangipane, Francesca; Cupidi, Chiara; Bernardi, Livia; Anfossi, Maria; Gallo, Maura; Conidi, Maria Elena; Smirne, Nicoletta; Rademakers, Rosa; Baker, Matt; Dickson, Dennis W; Graff-Radford, Neill R; Petersen, Ronald C; Knopman, David; Josephs, Keith A; Boeve, Bradley F; Parisi, Joseph E; Seeley, William W; Miller, Bruce L; Karydas, Anna M; Rosen, Howard; van Swieten, John C; Dopper, Elise G P; Seelaar, Harro; Pijnenburg, Yolande A L; Scheltens, Philip; Logroscino, Giancarlo; Capozzo, Rosa; Novelli, Valeria; Puca, Annibale A; Franceschi, Massimo; Postiglione, Alfredo; Milan, Graziella; Sorrentino, Paolo; Kristiansen, Mark; Chiang, Huei-Hsin; Graff, Caroline; Pasquier, Florence; Rollin, Adeline; Deramecourt, Vincent; Lebert, Florence; Kapogiannis, Dimitrios; Ferrucci, Luigi; Pickering-Brown, Stuart; Singleton, Andrew B; Hardy, John; Momeni, Parastoo

    2014-07-01

    Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72--have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. To reduce genetic heterogeneity, all participants were of European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10(-8)) single-nucleotide polymorphisms. We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10(-8)). Combined (joint) analyses of discovery and replication phases showed genome-wide significant association at 6p21.3, HLA locus (immune system), for rs9268877 (p=1·05 × 10(-8); odds ratio=1·204 [95% CI 1·11-1·30]), rs9268856 (p=5·51 × 10(-9); 0·809 [0·76-0·86]) and rs1980493 (p value=1·57 × 10(-8), 0·775 [0·69-0·86]) in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC (the transcripts of which are related to lysosomal biology), for the behavioural FTD subtype for which joint analyses showed suggestive association for rs302668 (p=2·44 × 10(-7); 0·814 [0·71-0·92]). Analysis of expression and methylation quantitative trait loci data

  13. Criterion of cleavage crack propagation and arrest in a nuclear PWR vessel steel

    International Nuclear Information System (INIS)

    Bousquet, Amaury

    2013-01-01

    The purpose of this PhD thesis is to understand physical mechanisms of cleavage crack propagation and arrest in the 16MND5 PWR vessel steel and to propose a robust predicting model based on a brittle fracture experimental campaign of finely instrumented laboratory specimens associated with numerical computations. First, experiments were carried out on thin CT25 specimens at five temperatures (-150 C, -125 C, -100 C, -7 C, -50 C). Two kinds of crack path, straight or branching path, have been observed. To characterize crack propagation and to measure crack speed, a high-speed framing camera system was used, combined with the development of an experimental protocol which allowed to observe CT surface without icing inside the thermal chamber and on the specimen. The framing camera (520 000 fps) has allowed to have a very accurate estimation of crack speed on the complete ligament of CT (∼ 25 mm). Besides, to analyse experiments and to study the impact of viscosity on the mechanical response around the crack tip, the elastic-viscoplastic behavior of the ferritic steel has been studied up to a strain rate of 104 s -1 for the tested temperatures.The extended Finite Element Method (X-FEM) was used in CAST3M FE software to model crack propagation. Numerical computations combine a local non linear dynamic approach with a RKR type fracture stress criterion to a characteristic distance. The work carried out has confirmed the form of the criterion proposed by Prabel at -125 C, and has identified the dependencies of the criterion on temperature and strain rate. From numerical analyzes in 2D and 3D, a multi-temperature fracture stress criterion, increasing function of the strain rate, was proposed. Predictive modeling were used to confirm the identified criterion on two specimen geometries (CT and compressive ring) in mode I at different temperatures. SEM observations and 3D analyzes made with optical microscope showed that the fracture mechanism was the cleavage associated

  14. Hydrogen diffusion and effect on degradation in welded microstructures of creep-resistant low-alloyed steels

    Energy Technology Data Exchange (ETDEWEB)

    Rhode, Michael

    2016-04-04

    with the permeation technique at room temperature and at elevated temperature ranges up to 400 C - It was investigated by interpreting the hydrogen effusion behavior with carrier gas hot extraction technique (CGHE). For realistic determination of the hydrogen diffusion coefficients, an improved method was developed encompassing accelerated specimen heating and hydrogen determination via mass spectrometer (MS). Simultaneously, the corresponding temperature dependent trapped and total hydrogen concentrations were determined. The determined experimental results showed increased susceptibility to the hydrogen affected degradation of the HAZ compared to the base material, which is independent of the investigated alloy composition. In particular, the martensitic coarse grain HAZ is the most susceptible microstructure to hydrogen-affected degradation. The results of the tensile tests allowed the definition of consistent microstructure specific failure criteria (envelope curves) versus quantified hydrogen concentrations for the reactor pressure vessel 16MND5 steel (20MnMoNi-5-5) and the creep-resistant T24 steel (7CrMoVTiB10-10). The procedure of quantifying hydrogen concentrations in HAZ microstructures is novel and supports a new method of analysis for hydrogen degradation effects. Further investigations with the T22 steel (10CrMo9-10), as compared to the creep-resistant T24 steel (7CrMoVTiB10-10), confirmed the beneficial effect of Vanadium as an alloying element to improve the resistance to degradation. In general, Mn-Mo-Ni base material grades show a higher resistance compared to Cr-Mo steels that do not include Vanadium alloying. The investigations showed the decreased diffusion coefficient of the HAZ microstructure compared to the base material microstructure. This is caused by the stronger trapping effects that are present which simultaneously increase the hydrogen solubility as well. In general, trapping effects above 100 C are negligible. It is noted that after

  15. Hydrogen diffusion and effect on degradation in welded microstructures of creep-resistant low-alloyed steels

    International Nuclear Information System (INIS)

    Rhode, Michael

    2016-01-01

    the permeation technique at room temperature and at elevated temperature ranges up to 400 C - It was investigated by interpreting the hydrogen effusion behavior with carrier gas hot extraction technique (CGHE). For realistic determination of the hydrogen diffusion coefficients, an improved method was developed encompassing accelerated specimen heating and hydrogen determination via mass spectrometer (MS). Simultaneously, the corresponding temperature dependent trapped and total hydrogen concentrations were determined. The determined experimental results showed increased susceptibility to the hydrogen affected degradation of the HAZ compared to the base material, which is independent of the investigated alloy composition. In particular, the martensitic coarse grain HAZ is the most susceptible microstructure to hydrogen-affected degradation. The results of the tensile tests allowed the definition of consistent microstructure specific failure criteria (envelope curves) versus quantified hydrogen concentrations for the reactor pressure vessel 16MND5 steel (20MnMoNi-5-5) and the creep-resistant T24 steel (7CrMoVTiB10-10). The procedure of quantifying hydrogen concentrations in HAZ microstructures is novel and supports a new method of analysis for hydrogen degradation effects. Further investigations with the T22 steel (10CrMo9-10), as compared to the creep-resistant T24 steel (7CrMoVTiB10-10), confirmed the beneficial effect of Vanadium as an alloying element to improve the resistance to degradation. In general, Mn-Mo-Ni base material grades show a higher resistance compared to Cr-Mo steels that do not include Vanadium alloying. The investigations showed the decreased diffusion coefficient of the HAZ microstructure compared to the base material microstructure. This is caused by the stronger trapping effects that are present which simultaneously increase the hydrogen solubility as well. In general, trapping effects above 100 C are negligible. It is noted that after testing

  16. 6th International Symposium on Molecular Allergology (ISMA

    Directory of Open Access Journals (Sweden)

    Christiane Hilger

    2016-10-01

    hypoallergenic variant of the major peanut allergen Ara h 2 for allergen-specific immunotherapy Angelika Tscheppe, Dieter Palmberger, Merima Bublin, Christian Radauer, Chiara Palladino, Barbara Gepp, Nina Lengger, Reingard Grabherr, Heimo Breiteneder P36 Mutagenesis of amino acids critical for calcium-binding leads to the generation of a hypoallergenic Phl p 7 variant Marianne Raith, Linda Sonnleitner, Doris Zach, Konrad Woroszylo, Margit Focke-Tejkl, Herbert Wank, Thorsten Graf, Annette Kuehn, Ines Swoboda P37 Are birch pollen allergen immunotherapy induced blocking antibodies protective for cross-reactive allergens? Claudia Asam, Sara Huber, Heidi Hofer, Roland Lang, Thomas Hawranek, Fátima Ferreira, Michael Wallner P38 High success of 58 subcutaneous immunotherapy for pets allergy in a polyallergic cohort of patients: a component resolved individually adapted treatment (CRIAT Fabienne Gay-Crosier P39 Neutrophils are potential antigen presenting cells in IgE- mediated allergy Dominika Polak, Birgit Nagl, Claudia Kitzmüller, Barbara Bohle P40 Characterization of allergen-specific CD8+ T cells in type I allergy Nazanin Samadi, Claudia Kitzmüller, Rene Geyeregger, Barbara Bohle, Beatrice Jahn-Schmid Poster Session 5: Molecular and cellular diagnostic tests P41 Nanofluidic-based biosensors allow quantification of total circulating IgE from a drop of blood in 5 minutes Aurélie Buchwalder, Ariel Gomez, Fabien Rebeaud, Iwan Märki P42 Allergen microarray for the analysis of serum IgE binding profile and allergenic activity Jaana Haka, Liisa Hattara, Marika Heikkinen, Merja H Niemi, Juha Rouvinen, Petri Saviranta, Pekka Mattila, Kristiina Takkinen, Marja-Leena Laukkanen P43 Generation of a well-characterized panel of periplaneta americana allergens for component resolved diagnosis Stephanie Eichhorn, Isabel Pablos, Bianca Kastner, Bettina Schweidler, Sabrina Wildner, Peter Briza, Jung-Won Park, Naveen Arora, Stefan Vieths, Gabriele Gadermaier, Fatima Ferreira P44 Improved