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Sample records for karim kanso2 faron

  1. karim chikh

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. KARIM CHIKH. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 36. Acid-activated bentonite (Maghnite-H + ) as a novel catalyst for the polymerization of decamethylcyclopentasiloxane · DJAMAL EDDINE KHERROUB MOHAMMED BELBACHIR ...

  2. Ere plastikupoeet Karim Rashid / Kadi Lehtmets

    Index Scriptorium Estoniae

    Lehtmets, Kadi

    2007-01-01

    Kairos 1960. a. sündinud disainerist Karim Rashidist, kelle lemmikmaterjaliks on plast. Tema raamatutest "Ma tahan muuta maailma" ja "Design Your Self" (2004), disainitud toodetest, Deutsche Bank VIP Lounge'i ja Ateena Semiramise hotelli (sai Sleep05 Euroopa hotellidisaini auhinna) kujundusest. 16 ill

  3. KRITIK ATAS KRITIK EPISTEMOLOGI TAFSIR M. ABIED AL JABIRI: Studi Kritis atas Madkhal ila al Quran al Karim

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    Ahmad Fawaid

    2015-12-01

    Full Text Available This paper critically views the epistemology of Muhammad Abid al Jabiri’s interpretation in his book, Madkhal ila al Quran al Karim. His latest work is projected to make the Quran relevant to mankind today and with certainly critiquing classical Quranic studies that have been constructed by previous scholars. Starting from Arab criticism, which is expected to synergize the gap between Turath and modernity, al Jabiri tried out his theory in the realm of Quranic studies oriented to maintain its originality and interpretation from sectarian influence. Focusing on al Jabiri’s review on the Quran, this paper examines and associates some of the problems with the epistemology of critique in Arab reasoning. Finally, it is inferred that the epistemologic offer of al Jabiri used in Turath is not fully applicable in Quranic studies for several reasons. First, the Quranic studies existed within the chain of sanad in its formation. Secondly, at the application stage, al Jabri often overlooked the sanad and narrations from the companions.

  4. A propósito de un caso de anquilobléfaron

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    Jorge Luis Díaz González

    Full Text Available Se presenta el caso de un neonato de 9 días, masculino y de piel negra, que es remitido a la Consulta de Oftalmología del Hospital Pediátrico "William Soler" de La Habana, por el pediatra de su área de salud debido a trastorno funcional del párpado. Al examen oftalmológico se detecta la fusión de los párpados superior e inferior del ojo izquierdo, principalmente en el ángulo externo, con limitación de la separación de estos y sus movimientos normales. Luego de descartar la existencia de otras malformaciones congénitas asociadas, a nivel ocular o sistémico, fue intervenido quirúrgicamente para reparar la anomalía con evolución favorable hasta el alta médica.

  5. Anquilobléfaron filiforme adherente y otras malformaciones Ankyloblepharon filiforme adnatum and other malformations

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    Josefa Rodríguez Vargas

    2003-06-01

    Full Text Available Se realizó un examen físico a un recién nacido con malformaciones presentadas en el momento del parto, de un embarazo valioso de la raza negra, presentó los párpados superior e inferior de ambos ojos unidos por finas bandas en número variable que impedían la separación y los movimientos normales. Además asociado a labio leporino y hendidura palatina. Luego de descartar otras malformaciones congénitas, fue intervenido para reparar la malformación. Su estado actual es normal, después de la recanalización de sus otras anomalías.A physical examination was made to a newborn of the black race with malformations at the time of delivery. His upper and lower eyelids were united by a variable number of fine bands that impeded the separation and the normal movements. It was also associated with cleft lip and palate. After discarding other congenital malformations, he was operated on to repair the malformation. His present state is normal after the recanalization of his other abnormalities.

  6. Traditional healers and AIDS prevention | Abdool Karim | South ...

    African Journals Online (AJOL)

    Her questionable beliefs included a Nazi conspiracy as the source of AIDS, a string ritual to prevent promiscuity and a conviction that she could treat AIDS. Notwithstanding the latter beliefs, her generally factual knowledge of AIDS indicated that she could be an important source of AIDS information in the community; she ...

  7. 579-IJBCS-Article-Dr Karim Traoré

    African Journals Online (AJOL)

    DR GATSING

    Au Burkina Faso, 86% de la population active travaille dans l'agriculture. Cependant la production .... chimiques et biologiques des sols et ces changements sont à la .... (WTW 521) dans une suspension compost-eau de ratio 1:2,5 Le C total, ...

  8. Allelopathic potential of selected rice varieties | Karim | African ...

    African Journals Online (AJOL)

    Average percent inhibition (API) in lettuce due to allelopathic effect of different rice varieties/lines was estimated. Under greenhouse conditions, double-pot technique was followed using barnyard grass (Echinochloa crusgalli L.) as indicator plant. The changes in barnyard grass plant charcters due to allelopathic effect of ...

  9. 2801-IJBCS-Article-Youssao Abdou Karim Issaka

    African Journals Online (AJOL)

    hp

    stratégies de lutte et de contrôle de la fièvre aphteuse varient d'une région à une autre. (Gorna et al., 2014) et ... d'Afrique de l'Est, ont adopté la stratégie de zones indemnes sans vaccin pour accéder aux commerces .... d'appareil photo numérique et de l'Herbier. National du Bénin. Méthodes d'enquête. Les données ont ...

  10. Pemikiran Filosofis Sadra Dalam Tafsir Al-Qur’an Al-Karim : Surah Al-’A‘la

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    Kerwanto Kerwanto

    2014-12-01

    Full Text Available Abstrak : Dalam tafsir atas Surah al-’A‘lā, Mulla Sadra, melalui karyanya Tafsīr al Qur’ān al-Karīm, mengajak jiwa kita berpetualang menuju lapisan makna terdalam untuk mengenali realitas ketauhidan (al- mabdā’, kenabian (shirāth atau nubuwwah dan kebangkitan (ma‘ād dan mengulasnya secara filosofis. Penelitian ini merupakan suatu upaya untuk menggali manfaat dari aspek-aspek penting dari sumber-sumber keagamaan yang tergali dari petunjuk al Qur’an yang berpadu dengan prinsip- prinsip rasional filosofis dan pengalaman mistik (intuitif Sadra. Setiap bab pada tafsir ini diberikan judul dengan tasbīḥ (pernyataan pemujian dan pensucian, dengan tetap memaparkan beragam pokok persoalan terkait metafisika al-Qur’an. Prinsip-prinsip filosofis yang digunakan dalam risalah tafsir ini bisa menjadi salah satu bukti ketidakberjarakan antara filsafat dengan teks-teks keagamaan. Sadra menggunakan metode tafsir yang tetap menerima sisi lahiriah al-Qur’an, dan selanjutnya mencari misteri-misteri, rahasia-rahasia, dan dengan bantuan intelek (akal, intuisi dan iluminasi Tuhan untuk memperoleh realitas-realitas dan makna- makna dibalik selaput ekternalnya (aspek literalnyaKata kunci : Ḥikmah Muta’āliyah, irfan, al-mabdā’, kebangkitan setelah mati, nubuwwah, takwīl, gerak substansial (ḥarakah jawhariyyah, denotasi utama (al-maqshūd al-ashlī, penyempurnaan diri (takammul, tasbīḥ.  Abstract : In his commentary on Surah al-’ A‘lā, Mulla Sadra, through his Tafsīr al-Qur’ān al-Karīm invites our souls to ventureinto the deepest layers of meaning to recognize the reality of Divinity (al- mabdā’, prophethood (Ṣirāṭ or nubuwwah and resurrection (ma‘ād and discusses it in a more philosophical manner. This study is an attempt to explore the benefits of these important aspects of religious sources unearthed from Qur’anic injunctions combined with rational principles of philosophical and mystical experiences (intuitive of Sadra. Each chapter in this commentary is assigned a title with tasbīḥ (glorification, while presenting various issues related to metaphysics of Qur’an.Thephilosophical principles used in the interpretation of this treatise could be a proof of harmony between philosophy and religious texts. This kind of interpretation accepts the literal meaning (ẓāhir of lafaẓ al Qur’ān, and then with the aid of reason, intuition and revelation uncover the reality behind them; the search for the secrets behind the literal sense.Keywords : Ḥikmah Muta’āliyah, irfān,  al-mabdā’, ma‘ād, nubuwwah, ta’wīl, substantial motion (ḥarakah jawhariyyah, original meaning (al-maqṣūd al-aṣlī, perfection (takammul, tasbīḥ.

  11. PEMIKIRAN HAJI ABDUL MALIK KARIM AMRULLAH (HAMKA TENTANG PARTISIPASI POLITIK PEREMPUAN DI INDONESIA TAHUN (1949 – 1963

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    Sarah Larasati Mantovani

    2015-06-01

    Full Text Available Since Mary Wollstonecraft demanded equal rights for women in all fields and denounced all forms of discrimination in her book A Vindication of the Rights of Women in 1792, feminist movements began to emerge and demand the same thing, including the right to participate in politics. Indonesia, which was still called the archipelago, then had given right to women to participate in politics. The motivation of political participation of women in Indonesia was different from that of the Westerners. The motivation of the former was based on a religious spirit, not the spirit of feminism as stated by Hamka in his book Tjemburu (Ghirah. Based on this, this research focuses on Hamka’s thought on Indonesian women political participation. The purpose of this study is to explore and analyze Hamka's thoughts, and construct them, and then associate them with the current Indonesian women political participation. This research is qualitative, based on library research, and done by reviewing, tracking, and analyzing data from the books and newspaper archives. This study uses historical and philosophical. The research data are derived from primary and secondary data sources. The primary data ones are divided into two: first, the primary data sources from Hamka's books that tell about women and women's political participation in general, and, second, the primary data sources from Hamka's books that specifically discuss about Indonesian women's political participation. Analysis of data uses deductive and reflective methods. Based on the results of this research, we can conclude that Hamka had underlined his political thought construction by making the divine revelation as the supreme law. Hamka strengthened the construction of his thought on women's political participation with the element of unity of I'tiqad. This I'tiqad unity was not only in women but also in men, so that they could work together to build a religious Muslim community. Hamka himself basically allowed women (especially a muslim woman to participate in politics as long as they had religious understanding, knowledge, and high Islamic morale, did not forget their main tasks as wives and mothers, were critical, and dare. Then it could be found as well, the two types of Indonesian women's political participation Hamka's thought, they were based on motivation and activities.

  12. Al-Isykaliyyat al-Lughawiyyah fi Tarjamah Ma'ani al-Qur'an al-Karim ila al-Lughah al-Indonisiyyah

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    Saifullah Kamalie

    2011-05-01

    Full Text Available Translating the Qur’an into Indonesian language, is a crucial issue, complicated and difficult. Because the Qur’an has a structure, pattern, and style of a particular language that can not be interpreted as translating Arabic books other. Although understand the Qur’an without going through the translation into Indonesian, is clearly more difficult. Recognizing the need for Qur’anic translation, the writer attempts to affirm the various aspects before translating to eliminate some errors, in terms of both language and content. From the translator qualifications he must understand well a few things; understand well the target and source language, semantics, and distinguish various linguistic structures such as synonyms, antonyms, and metaphor. According to Mildred L. Larsen, a translator must consider three aspects; a. differences in characteristics of language, b. sort out the confusion between the source language and its target, c. recognize the differences in the context of the uses of each word. Last but not least, the authors expect no results for translations of the Qur’an which maintained the validity – at least approached with the intention of the verses of the Qur’an – so it helps to understand the Qur’an properly. For that, the authors suggested, there needs to be a special team consisting of language experts and competent to translate the Qur’an in a collocation and groups.

  13. Sluglett Peter with Weber Stefan (éd., Syria and Bilad al-Sham under Ottoman Rule. Essays in honour of Abdul-Karim Rafeq, Leyde, Brill, 2010, 633 p.

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    Catherine Mayeur-Jaouen

    2013-10-01

    Full Text Available Un an avant le printemps arabe de 2011 qui coïncida avec son quatre-vingtième annniversaire, le grand historien syrien Abdulkarim Rafeq s’était vu offrir en 2010 ce beau volume de Mélanges, fruit d’un colloque tenu en 2004 à Damas et à Beyrouth. La cohérence de l’œuvre de Rafeq (l’histoire du Bilād al-Shām ottoman à travers les archives dont il est un connaisseur hors pair comme le caractère bilingue de sa formation (Collège américain à Alep, Université syrienne à Damas, un doctorat à la SOA...

  14. منهج النورسي في إحصاء أسماء الله الحسنى - ‘Abd al-Karim ‘Akiwi: Nursi’s Method of Enumerating the Divine Names

    OpenAIRE

    عكيوي, أ. د. عبد الكريم

    2010-01-01

    منهج النورسي في إحصاء أسماء الله الحسنى د. عبد الكريم عكيوي1 الحمد لله رب العالمين والصلاة والسلام على إمام المرسلين وخاتم النبيين، وعلى آله وأزواجه وذريته وأهل بيته، وعلى التابعين وتابعيهم بإحسان إلى يوم الدين. أما بعد، فإن الأسماء الحسنى ثابتة لله تعالى قطعا، وذلك بنص القرآن الكريم والسنة النبوية. وقد جعل الله تعالى معرفة أسمائه طريقا إلى معرفته، لأن معرفة الله بحقيقة ذاته متعذر في الحياة الدنيا لأن رؤية ذاته تعالى هي الجزاء الأوفى الذي أعده لمن فاز برضوانه، فرؤية وجه الله تعالى تحصل به ل...

  15. South African Medical Journal - Vol 79, No 3 (1991)

    African Journals Online (AJOL)

    Under-reporting in hepatitis B notifications · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S.S. Abdool Karim, Q Abdool Karim, 242-244 ... Non-cirrhotic portal hypertension entity in South Africa? A report of 6 cases · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  16. ORIGINAL ARTICLES

    African Journals Online (AJOL)

    . PARTNERSHIPS FOR STD. CONTROL IN SOUTH AFRICA-. PERSPECTIVES FROM THE. HLABISA EXPERIENCE. David Wilkinson, Salim S Abdool Karim, Mark Lurie,. Abigail Harrison. Sexually transmitted diseases (STDs) are epidemic in.

  17. Browse Title Index

    African Journals Online (AJOL)

    , L'effet de l'extubation precoce apres chirurgie cardiaque pour la rehabilitation post opératoire, Abstract PDF. Hichem Cheikhrouhou, Amine Kharrat, Rahma Derbel, Yesmine Ellouze, Karim Jmal, Hela Ben Jmaa, Mohamed Ali Elkamel, Imed ...

  18. The new survivors and a new era for trauma research.

    Science.gov (United States)

    Brohi, Karim; Schreiber, Martin

    2017-07-01

    Karim Brohi and Martin Schreiber, Guest Editors of the Special Issue on Trauma, describe a new era in exploration of the biology of injury response and translation of new opportunities into clinical practice.

  19. The new survivors and a new era for trauma research

    OpenAIRE

    Brohi, Karim; Schreiber, Martin

    2017-01-01

    Karim Brohi and Martin Schreiber, Guest Editors of the Special Issue on Trauma, describe a new era in exploration of the biology of injury response and translation of new opportunities into clinical practice.

  20. Article

    African Journals Online (AJOL)

    FDB

    of scholarly communication (Singeh, Abrizah & Karim, 2012; Dutta & Paul, 2014). The use of IR is ..... Self- archiving. Through the. Library staff. Through a colleague. No response. N (%). N. (%). N. (%) N ... work deposited in IR in a peer reviewed journal .... people from different organizations and countries. She is a member ...

  1. Development of somaclones in sugarcane genotype BF-162 and ...

    African Journals Online (AJOL)

    pris

    2012-02-21

    Feb 21, 2012 ... Baksha R, Alam R, Karim MZ, Paul SK, Hossain MA, Miah MAS,. Rahman ABMM (2002). In vitro Shoot Tip Culture of Sugarcane. (Saccharum officinarum) Variety Isd 28. Int. Quarterly J. Biotech. 1: 67-72. Brisibe E, Miyake AH, Taniguchi T, Maeda E (1994). Regulation of somatic embryogenesis in long-term ...

  2. Clinical application of sensory integration therapy for children with ...

    African Journals Online (AJOL)

    Nazurah Alwi

    skills in children with autism'' by Abdel Karim and. Mohammed [1]. Sensory integration therapy (SIT) is the most common interventions delivered to children with aut- ism spectrum disorder (ASD) who have atypical sensory behavior [2]. We applaud ... the author why they have not considered 6–9 year old chil- dren as they ...

  3. Preparation, characterization and photocatalytic activity of TiO2 ...

    Indian Academy of Sciences (India)

    Photocatalyst; TiO2 nanoparticle; polyaniline; conducting polymer; core-shell nanocomposite. 1. Introduction ..... tine TiO2 nanoparticles, HCl-doped PANI and PANI/TiO2 ..... Karim M R, Lim K T, Lee M S, Kim K and Yeum J H 2009 Synth. Met.

  4. African Journal of Biotechnology - Vol 12, No 19 (2013)

    African Journals Online (AJOL)

    Production and optimization of L-asparaginase by Bacillus sp. KK2S4 from corn cob · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. EA Makky, Jee Jian Ong, Md. Rezaul Karim, CM Lee ...

  5. Répartition et valorisation des macrophytes envahissantes dans la ...

    African Journals Online (AJOL)

    SARAH

    30 avr. 2016 ... showed that 2 species (Eichhornia crassipes and Panicum maximum) were the most represented. Sorensen ... d'E. crassipes apparaît comme un danger à juguler. (Karim et ... déséquilibre et la diminution voire l'extinction de.

  6. Case series

    African Journals Online (AJOL)

    abp

    19 oct. 2017 ... Traitement des amyloses AL systémiques: à propos de 25 cas. Treatment of systemic AL amyloidosis: about 25 cases. Hicham Eddou1,&, Ali Zinebi1, Hicham El Maaroufi2, Mohammed Karim Moudden1, Kamal Doghmi2, Mohammed Mikdame2,. Mohammed El Baaj1. 1Service de Médecine Interne, Hôpital ...

  7. (HIV) Infection in Pregnant Women in Amassoma, Nigeria.

    African Journals Online (AJOL)

    Bioline

    Karim et al 2002]. Because AIDS tend to strike young adults and workers in their prime, the AIDS epidemic is having devastating effects on social and economic structure in some countries. The World Health. Organization estimates that of 5 million ...

  8. Browse Title Index

    African Journals Online (AJOL)

    Mohammed Shimi, Hicham Mahdane, Atif Mechchat, Abedelhalim El Ibrahimi, Abedelmajid El Mrini. Vol 20, No ... Brahim Bouaity, Mehdi Chihani, Mohammed Touati, Youssef Darouassi, Karim Nadour, Haddou Ammar. Vol 27, No ... Kaouther Dimassi, Rim Sahnoun Moalla, Sami Abid, Bechir Zouari, Mohamed Faouzi Gara.

  9. African Journal of Urology

    African Journals Online (AJOL)

    Ktari Kamel, Sarhen Gassen, Mahjoub Mohamed, Ben Kalifa Bader, Klaii Rim, Karim Bouslam, Saidi Radhia, Jelled Anis, Saad Hamadi, 14-18 ... Two pelvises, one stone: A different approach for management of calculi in a duplex renal collecting system · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD ...

  10. African Journal of Urology - Vol 24, No 1 (2018)

    African Journals Online (AJOL)

    Ktari Kamel, Sarhen Gassen, Mahjoub Mohamed, Ben Kalifa Bader, Klaii Rim, Karim Bouslam, Saidi Radhia, Jelled Anis, Saad Hamadi, 14-18 ... Two pelvises, one stone: A different approach for management of calculi in a duplex renal collecting system · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD ...

  11. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Sensitivity in the trajectory of long-range -particle · P V Kunhikrishnan A Rajan Nambiar K P Santhosh · More Details Abstract Fulltext ... pp 471-481. Probing ultrafast carrier dynamics, nonlinear absorption and refraction in core–shell silicon nanowires · Sunil Kumar M Khorasaninejad M M Adachi K S Karim S S Saini A K ...

  12. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    The method of application of critical bed shear stress equations is also mentioned. Volume 29 Issue 1 February 2004 pp 35-56. Velocity and turbulence at a wing-wall abutment · Abdul Karim Barbhuiya Subhasish Dey · More Details Abstract Fulltext PDF. Experimental investigation of the 3D turbulent flow field around a 45° ...

  13. R : disaini alfabeet / Kai Lobjakas

    Index Scriptorium Estoniae

    Lobjakas, Kai, 1975-

    2007-01-01

    Tutvustatakse Ameerika graafilise disaini euroopalikumaks muutjat Paul Rand'i, sisearhitekti Toivo Raidmetsa, rahvusvahelise taustaga disainerit Karim Rashid'i, keraamikut ja pedagoogi Leo Rohlinit ja kunsti radikaalseks uuendamiseks asutatud rühmituse (1917.a.) De Stijl üht hilisemat liiget Gerrit Rietveldi

  14. Genetic diversity in Entamoeba histolytica

    Indian Academy of Sciences (India)

    C Graham Clark1 Mehreen Zaki2 Ibne Karim Md Ali1. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK; Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E ...

  15. Extending Methods: Using Bourdieu's Field Analysis to Further Investigate Taste

    Science.gov (United States)

    Dimick, Alexandra Schindel

    2015-01-01

    In this commentary on Per Anderhag, Per-Olof Wickman and Karim Hamza's article "Signs of taste for science," I consider how their study is situated within the concern for the role of science education in the social and cultural production of inequality. Their article provides a finely detailed methodology for analyzing the constitution…

  16. Mobile Advertising and Its Impact on the Customers Mind: Case of ...

    African Journals Online (AJOL)

    India). S Karim, SK Reddy. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/star.v2i1.98854 · AJOL African Journals Online.

  17. Browse Title Index

    African Journals Online (AJOL)

    Vol 16, No 2 (2012), Identification par coprologie des helminthes de python regius dans le département du zou au Bénin, Afrique de l'Ouest, Abstract. MN Assogba, IYA Karim, IT Akoiret, F Fagbohoun, EN Zannou. Vol 9, No 2 (2007), IGNAME, PLANTE ALIMENTAIRE COMMERCIALE ET CULTURELLE AU NORD BENIN ...

  18. Fulltext PDF

    Indian Academy of Sciences (India)

    SEARCHU

    of adult tissue. Abnormal Wnt signalling has been implicated in disorders such as cancers and degenerative diseases (Karim et al 2004; Logan and Nusse 2004; Moon et al 2004). Members of the hedgehog pathway play an important role in mammalian embryonic development as well as in oncogenic transformation ...

  19. Building a Flexible Nework Infrastructure for Moving Target Defense

    Science.gov (United States)

    2017-10-13

    testbed. We have published a paper in the CAN Workshop held in conjunction with the ACM CoNext 2016 conference [3]. ML implementations on OpenNetVM...Artificial Intelligence applications in the network Workshop held in conjunction with IEEE ICNP 2017 [4]. [1] Azeem Aqil, Karim Khalil, Ahmed Atya

  20. Bacterial enteropathogens associated with diarrhea in a rural population of Haiti

    Directory of Open Access Journals (Sweden)

    Jackson JC

    2011-09-01

    Full Text Available John C Jackson, Anthony L Farone, Mary B Farone Biology Department, Middle Tennessee State University, Murfreesboro, Tennessee, USA Purpose: Diarrheal disease is one of the leading causes of morbidity in developing countries. To further understand the epidemiology of diarrheal disease among a rural population surrounding Robillard, Haiti, fecal swabs from patients with diarrhea were screened for the presence of enteropathogenic bacteria. Patients and methods: Fecal swabs were collected from 34 patients with signs and symptoms of diarrhea and stored in BBLTM Cary-Blair transport medium (Becton, Dickinson and Company, Sparks, MD until transit to the USA. Swab material was inoculated on to different enrichment and selective agars for incubation. Fermenting and nonfermenting bacteria that grew on the enteric selection media were identified by the BBLTM CrystalTM Enteric/Nonferementing Identification system (Becton, Dickinson and Company. Organisms identified as Escherichia coli were further screened for the presence of virulence factors by polymerase chain reaction (PCR. Results: Of 34 patients, no Campylobacter, Shigella, Salmonella, or Vibrio spp. were isolated from swabs transported to the USA for culture. Of 73 E. coli isolates cultured from the swabs, one enteropathogenic strain of E. coli was identified by multiplex PCR. Escherichia fergusonii and Cronobacter sakazakii, both potential gastrointestinal pathogens, were also isolated from patient stools. Conclusion: This study was undertaken to determine if bacterial enteropathogens could be detected in the stools of patients suffering from diarrhea or dysentery and, in the absence of sufficient facilities, rectal swabs could be transported to the USA for culture. Although several genera of overt enteropathogens were not detected, one enteropathogenic E. coli and other pathogenic enterobacteriaceae were successfully cultured and identified. Keywords: Escherichia, Cronobacter, diarrheagenic, stool

  1. Sejarah Keberadaan Muhammadiyah di Minangkabau Perspektif Hamka dalam Karya “Ayahku”

    Directory of Open Access Journals (Sweden)

    Muhamad Ikbal

    2018-01-01

    Full Text Available This research is aimed to describe of the first origin of Muhamadiyah in Minangkabau beside on Hamka perspective on his book “Ayahku”, about whom lead Muhamadiyah to Minangkabau, what is the background of Muhamadiyah brought to Minangkabau, and what about the response of Minangkabau society regarding the arrival of Muhamadiyah. This research using history method, mean while for presentation the result of research using descriptive narrative. The Phase of this research method has four elements, such as heuristic (collecting data, critic, interpretative, and historiography (written. The result of this research shows that Muhamadiyah brought to Minangkabau individually where it brought by Haji Abdul Karim Amrullah in 1925. Known Men who spread Muhamdiyah in Minangkabau is Syekh Jamil Jambek, St. Mansur, Sj St Mangkuto and his brother Yusuf Amrullah. Support factor that makes Muhamdiyah accepted in Minangkabau society is because Abdul Karim Amrullah and founder of Muhamdiyah K.H Ahmad Dahlan is a student of Syekh Khatib al Minangkabaui when studying in Mecca also when H.Abdul Karim Amrullah goes to java and his art asked by K.H.Ahmad Dahlan for rewritten in java language. Keywords : History, Muhammadiyah, Minangkabau, Hamka.   Abstrak Penelitian ini bertujuan untuk mendeskripsikan sejarah awal keberadaan Muhammadiyah di Minangkabau perspektif Hamka dalam karyanya “Ayahku”, tentang siapa yang membawa Muhammadiyah ke Minangkabau, apa latarbelakang Muhammadiyah dibawa ke Minangkabau, dan bagaimana respon masyarakat Minangkabau pada saat Muhammadiyah datang.Penelitian ini mengunakan metode sejarah, sementara untuk penyajian hasil penelitian dilakukan dalam bentuk deskriptif – naratif. Hasil penelitian yang telah dilakukan menunjukkan bahwa Muhammadiyah dibawa ke Minangkabau secara individual, yaitu dibawa oleh H.Abdul Karim Amrullah pada tahun 1925. Beliau membawa Muhammadiyah ke Minangkabau adalah untuk memperbaiki Agama Islam di Minangkabau

  2. The Body As Cogito: A Certain Contemporary Film In The Light of Merleau-Ponty

    Directory of Open Access Journals (Sweden)

    Julio Bezerra

    2014-04-01

    Full Text Available Contemporary film is displaying a kind of "transnational new wave" that seems unique since the mid-60s. Filmmakers as diverse as Tsai Ming-Liang, Karim Aïnouz, and Apichatpong Weerasethakul, show a similar sensitivity towards the values of the world and of the cinema. What brings the work of these directors together is the taste for a realism more focused on the phenomenon of experience, on issues of skin and surface, and a different look at the body. Our hypothesis is that the phenomenology of Merleau-Ponty provides us with valuable tools to broaden the debate. The discussion will be carried out by an analysis of the work of Tsai Ming-Liang, Apichatpong Weerasethakul and Karim Aïnouz.

  3. The educational environment of the undergraduate medical curriculum at Kuwait University

    OpenAIRE

    Karim J; Al-Halabi B; Marwan Y; Sadeq H; Dawas A; Al-Abdulrazzaq D

    2015-01-01

    Jumanah Karim,1 Becher Al-Halabi,2 Yousef Marwan,3 Hussain Sadeq,4 Ahmed Dawas,5 Dalia Al-Abdulrazzaq5 1Department of Pediatrics, Al-Amiri Hospital, Kuwait City, Kuwait; 2Department of Surgery, Mubarak Al-Kabeer Hospital, Kuwait City, Kuwait; 3Department of Orthopaedic Surgery, Al-Razi Orthopaedic Hospital, Kuwait City, Kuwait; 4Department of Pediatrics, Al-Adan Hospital, Kuwait City, Kuwait; 5Department of Pediatrics, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait Cit...

  4. Advanced Prosthetic Gait Training Tool

    Science.gov (United States)

    2015-12-01

    modules to train individuals to distinguish gait deviations (trunk motion and lower-limb motion). Each of these modules help trainers improve their...AWARD NUMBER: W81XWH-10-1-0870 TITLE: Advanced Prosthetic Gait Training Tool PRINCIPAL INVESTIGATOR: Dr. Karim Abdel-Malek CONTRACTING...study is to produce a computer-based Advanced Prosthetic Gait Training Tool to aid in the training of clinicians at military treatment facilities

  5. Le Viséen supérieur d'Azarhare (Maroc central) : environnements de dépôt, datation et évolution diagánótique

    Science.gov (United States)

    Karim, Atika; Berkhli, Mostafa; Vachard, Daniel; Tribovillard, Nicolas; Orberger, Beate

    2005-04-01

    The unexplored area of Azarhare in central Morocco is studied thanks to three sections composed of five lithological facies Main biostratigraphical and sedimentological results concern (1) the identification of Late Visean biozones, with important presence of problematic algae Ungdarella, (2) the regional extension of deposit sequences SD5, SD6 and SD7 previously defined, (3) and an analysis of the diagenetic kaolinite. To cite this article: A. Karim et al., C. R. Geoscience 337 (2005).

  6. Kaks vastandit / Anneliis Aunapuu

    Index Scriptorium Estoniae

    Aunapuu, Anneliis

    2005-01-01

    Saksa disainerist Konstantin Grcic'ist (s. 1965), kes kasutab materjalidest palju plasti (üks kuulsamaid töid on sõrestiktool "stool one"). Egiptuses sündinud Kanadas üles kasvanud disainerist Karim Rashid'ist (s. 1960), kelle lemmikmaterjaliks on samuti plast. Ühistööna valminud ideaalkodu installatsioonist Kölni mööblimessil 2003. a.

  7. Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation

    OpenAIRE

    Abdulbaqi,Ibrahim M; Darwis,Yusrida; Abou Assi,Reem; Abdul Karim Khan,Nurzalina

    2018-01-01

    Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia Introduction: Colchicine is used for the treatment of gout, pseudo-gout, familial Mediterranean fever, and many other illnesses. Its oral administration is associated with poor bioavailability and severe gastrointestinal side effects. The drug is also known to have a low therapeutic index. Thus to overcome these drawbacks, the...

  8. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

    OpenAIRE

    Abdulbaqi, Ibrahim M; Darwis, Yusrida; Khan, Nurzalina Abdul Karim; Assi, Reem Abou; Khan, Arshad A

    2016-01-01

    Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi, Arshad A Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Abstract: Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone exte...

  9. Positivity Preserving Interpolation Using Rational Bicubic Spline

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    Samsul Ariffin Abdul Karim

    2015-01-01

    Full Text Available This paper discusses the positivity preserving interpolation for positive surfaces data by extending the C1 rational cubic spline interpolant of Karim and Kong to the bivariate cases. The partially blended rational bicubic spline has 12 parameters in the descriptions where 8 of them are free parameters. The sufficient conditions for the positivity are derived on every four boundary curves network on the rectangular patch. Numerical comparison with existing schemes also has been done in detail. Based on Root Mean Square Error (RMSE, our partially blended rational bicubic spline is on a par with the established methods.

  10. Computer-Assisted Communication Device for Botulinum-Intoxicated Patients

    Science.gov (United States)

    2008-01-01

    development of small molecule therapeutics for botulinum neurotoxin and on the development of nerve agent pretreatments and therapies . He has published...Souayah, N., Karim, H., Kamin, S.S., McArdle, J. and Marcus, S. (2006) ‘Severe botulism after focal injection of botulinum toxin’, Neurology , Vol...67, pp.1855–1856. Tacket, C.O., Shandera, W.X., Mann, J.M., Hargrett, N.T. and Blake, P.A. (1984) ‘ Equine antitoxin use and other factors that

  11. Constitutive modeling for uniaxial time-dependent ratcheting of SS304 stainless steel

    International Nuclear Information System (INIS)

    Kan Qianhua; Kang Guozheng; Zhang Juan

    2007-01-01

    Based on the experimental results of uniaxial time-dependent ratcheting behavior of SS304 stainless steel at room temperature and 973K, a new time-dependent constitutive model was proposed. The model describes the time-dependent ratcheting by adding a static/thermal recovery into the Abdel-Karim-Ohno non-linear kinematic hardening rule. The capability of the model to describe the time-dependent ratcheting was discussed by comparing the simulations with the corresponding experimental results. It is shown that the revised unified viscoplastic model can simulate the time-dependent ratcheting reasonably both at room and high temperatures. (authors)

  12. Detecting and Targeting Oncogenic Myc in Breast Cancer

    Science.gov (United States)

    2007-06-01

    JPO2, with transforming activity in medulloblastoma cells. Cancer Res 2005, 65(13), 5607–5619. 58. Osthus RC, Karim B, Prescott JE, et al. The Myc...59. Prescott JE, Osthus RC, Lee LA, et al. A novel c-Myc- responsive gene, JPO1, participates in neoplastic transformation. J Biol Chem 2001, 276(51...Department of Medical Genetics and Microbiology , University of Toronto, 112 College Street, Toronto ON M5G 1L6, Canada 3 The Wistar Institute, 3601 Spruce

  13. Soft Tectonics

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette

    2011-01-01

    Until recently, analysis of the future was left to forecasters and trend experts. Today, however, designers and architects are playing an increasingly important role, creating products and environments that will change the way we live. Design Futures is a thought-provoking exploration......, and how we experience the human body. Featuring interviews with renowned designers, architects and trend forecasters – among them Karim Rashid, Toyo Ito and Li Edelkoort – and over 250 illustrations of futuristic products and concepts, this is a unique guide to some of the twenty-first century’s most...

  14. Browse Author Index

    African Journals Online (AJOL)

    Items 1 - 38 of 38 ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. K. Kalk, E · Kambugu, A · Kao, KY · Kaplan, R · Kaplan, R · Kara, S · Karamchand, L · Karim, A · Karlstrom, S · Katusiime, C · Kayembe, M · Keegan, Marilyn · Kelley, J · Kendall, C · Kenyon, C · Kerschberger, B · Kesieme, EB · Khabo, Paul · Khamisa ...

  15. Malaysia: where big is still better. For Malays, large families are part of the plan.

    Science.gov (United States)

    1993-11-03

    The benefits of various-sized families in Malaysia were discussed by several women and supplemented with official statements on family planning (FP). The Director of the National Population and Family Development, Dr. Raj Karim, advised that maternal health is jeopardized when women have more than five children. About 30% of reproductive age women in Malaysia have five or more children. A Federation of FP Associations spokesperson agreed that women should be advised of the dangers of bearing over five children, of the importance of spacing births two to four years apart, and of the ideal age of childbearing (21-39 years). The government lacks an official policy on family size. The government position is, however, compatible with Islamic teachings on spacing in order to protect the health of the mother and child. Islamic law does not permit sterilization or abortion. The "fatwas" of Islamic teaching may have been misconstrued by those not using any form of contraception. Dr. Karim, who has five children, reported that having a large family can be difficult for a woman with a job, a career, and a husband or when both parents work. Most Malays desire large families. The average Malay family size was 4.1 children in 1990; Malaysian Chinese have fertility of 2.3 children and Malaysian Indians have 2.6 children. People say that the benefits outweigh the hardships of a large family.

  16. Chemical clocks, oscillations, and other temporal effects in analytical chemistry: oddity or viable approach?

    Science.gov (United States)

    Prabhu, Gurpur Rakesh D; Witek, Henryk A; Urban, Pawel L

    2018-05-31

    Most analytical methods are based on "analogue" inputs from sensors of light, electric potentials, or currents. The signals obtained by such sensors are processed using certain calibration functions to determine concentrations of the target analytes. The signal readouts are normally done after an optimised and fixed time period, during which an assay mixture is incubated. This minireview covers another-and somewhat unusual-analytical strategy, which relies on the measurement of time interval between the occurrences of two distinguishable states in the assay reaction. These states manifest themselves via abrupt changes in the properties of the assay mixture (e.g. change of colour, appearance or disappearance of luminescence, change in pH, variations in optical activity or mechanical properties). In some cases, a correlation between the time of appearance/disappearance of a given property and the analyte concentration can be also observed. An example of an assay based on time measurement is an oscillating reaction, in which the period of oscillations is linked to the concentration of the target analyte. A number of chemo-chronometric assays, relying on the existing (bio)transformations or artificially designed reactions, were disclosed in the past few years. They are very attractive from the fundamental point of view but-so far-only few of them have be validated and used to address real-world problems. Then, can chemo-chronometric assays become a practical tool for chemical analysis? Is there a need for further development of such assays? We are aiming to answer these questions.

  17. Bladder injuries frequently missed in polytrauma patients

    Directory of Open Access Journals (Sweden)

    Tanweer Karim

    2010-05-01

    Full Text Available Tanweer Karim, Margaret Topno, Vinod Sharma, Raymond Picardo, Ankur HastirSurgery, MGM Medical College, Kamothe, Navi Mumbai, IndiaAbstract: Bladder injuries are very common in patients who have had road traffic accidents. The method of diagnosis and management of such injuries is well established and accepted. However, trauma to the bladder can be associated with other life-threatening injuries which are frequently missed, and often diagnosed during laparotomy for other reasons. The aim of this study was to diagnose bladder injury in polytrauma patients as early as possible, taking into consideration the fact that these patients are hemodynamically unstable and require rapid evaluation and management. In order to achieve our objective, we used bedside sonography with retrograde instillation of normal saline to diagnose bladder injury in addition to use of the conventional retrograde cystogram.Keywords: bladder injury, bladder rupture, retrograde cystogram

  18. GENEALOGI DAN PENYEBARAN THARIQAH QADIRIYAH WA NAQSHABANDIYAH DI JAWA

    Directory of Open Access Journals (Sweden)

    Aly Mashar

    2016-11-01

    Full Text Available This article investigates the geneology and spread of Thariqah Qadiriyah wa Naqshabandiyah in Java. Based on the previous literatures (Dhofier, Martin van Bruinessen, Zulkifli, and Mulyati, it was found out that in Java the genealogy of the thariqah formed by Syekh Ahmad Khatib Sambas directed to the three primary khalifah, i.e. Syekh Abdul Karim Banten, Syekh Ahmad Thalhah Cirebon, and Syekh Muhammad Hasbullah Madura, then spread out across Java Island through the four centers (on 1970s, such as Suryalaya, Rejoso, Mranggen, and Pangentongan. However, the writer found out that there were four khalifahs, including Syekhona Kholil Bangkalan Madura; with the nine dissemination centers (in 1970s including Berjan Purworejo, Sawah Pulo Surabaya, Cukir Jombang, Kencong Kediri, and Dawe Kudus.

  19. PARIWISATA; ANTARA TUNTUTAN INDUSTRI DAN KEARIFAN LOKAL

    Directory of Open Access Journals (Sweden)

    Abuya Busro Karim

    2012-05-01

    Full Text Available     Abuya Busro Karim (Penulis, Bupati Sumenep periode 2010-2015. e-mail: busyrokarim@yahoo.com     Abstract This simple article reflects the condition of tourism in Madura, particularly in Sumenep region. The fact describes that it has not been easy to  develop tourism place as it demonstratess in Bali. Toursim development must be natural (sunnatullah, however it finds any handicaps that needs wise response. Madurese tourism development must consider the following: Islam as the major religion of Madurese and the human resource. Hence, tourism must protect the local people become the victim of tourism industry. A good tourism industry is not only economic oriented but also it must gives substantial challenge to Islamic and Madures culture to take role in tourism industry. Kata-kata kunci pariwisata, budaya, Madura, Sumenep

  20. Cravo, canela, bala e favela Clove and cinnamon, guns and slums

    Directory of Open Access Journals (Sweden)

    Simone Pereira Schmidt

    2009-12-01

    Full Text Available A partir da discussão sobre o lugar do corpo feminino subalterno, palco de conflitos onde se desdobram as tensões resultantes das relações desiguais de gênero, raça e classe no Brasil, este artigo se propõe a realizar uma leitura de textos ficcionais recentes - nomeadamente os romances As mulheres de Tijucopapo, de Marilene Felinto, e Ponciá Vicêncio, de Conceição Evaristo, e o filme O céu de Suely, de Karim Aïnouz -, inserindo-os no debate de um projeto de tradução da agenda pós-colonial para o português. Decorrentes dessa abordagem, temas como a viagem, o deslocamento e o exílio farão parte da experiência subjetiva ficcionalizada que se irá enfocar, e serão, portanto, também objeto de interpretaçãoBased on the discussion about the subaltern woman's body as a stage of conflicts where the tensions resulting from Brazil's unequal gender, class and race relations unfold, this article intends to analyze recent fictional works - specifically the novels: Marilene Felinto's As mulheres de Tijucopapapo and Conceição Evaristo's Ponciá Vicêncio, as well as the film O céu de Suely, by Karim Aïnouz - in order to place them within the debate of translation of the post-colonial agenda into Portuguese. Focusing the subjective experience represented in these fictional narratives, themes like travel, dislocation and exile will also be analyzed

  1. Effect of Mycorrhizal Symbiosis and Azotobacter Application on Wheat (Triticum aestivum L. Qualitative Traits under Dry Condition of Khorramabad

    Directory of Open Access Journals (Sweden)

    behroz amraei

    2017-12-01

    . Azotobacter in tow levels of A1= inoculation and A2= no inoculationwere studied on three different Cultivars of Rain-fed wheat (V1: Sardari, V2: Kouhdasht, V3: Karim. In order to determine the N content of the seeds, the Kjeldahl methodology was used, and by multiplication of the N content of each sample in 5.83, the protein content of each sample was measured. Also P and K content of seeds were measured with spectrophotometry and flame spread (with AOAC standards respectively. Results and Discussion As a result, Azotobacter and Mycorrhiza had a significant effect on P content of three studied varieties of wheat in this research. The highest seed P content was measured in Azotobacter inoculated treatments (36% that showed a 9% superiority in compare to control. Also the treatment of seed with mycorrhiza caused a 36%increasement in P content which showes 12% superiority in compare to control.In three different varieties studied in this research, the highest seed P content was related to Karim variety. The effect of Variety on seed K content was significant and the highest amount was related to Sardari variety (63%. The effects of Azotobacter, Mycorrhiza and Variety on seed N content was significant, and the highest amount of seed N was related to a1v3 (Azotobacter inoculation on Karim variety treatment that showed 38.65% superiority in compare to the control. Also, Azotobacter*mycorrhiza*variety and Azotobacter*variety interactions on seed protein content was significant and the highest amount of seed protein percentage was related to a1v3 treatment (Azotobacter*Kraim variety that showed 40.44% superiority in compare to control. Conclusion Positive impacts of biofertilizers was observed in most of the studied traits of wheat in this study. The biggest amount of association of Azotobacter and and symbiosis of mycorrhiza with wheat was related to Karim variety. Also application of biofertilizers increased the accumulation of organic matter in soil, increasing root development

  2. MEMBUKA TABIR SUMPAH DALAM AL-QUR’AN (Studi Analisis Penafsiran ‘A’isyah Bint Al-Syati’ Tentang Ayat-Ayat Sumpah

    Directory of Open Access Journals (Sweden)

    Muhammad Hasdin Has

    2016-01-01

    Full Text Available Abstract This study discusses al-Aqsam fi al-Qur'an (Interpretation of 'A'isyah bint al-Shati 'in Kitab al-Tafsir al-Baya ni li al -Qur'a al-Karim. This research conducted library research by using the hermeneutics, philology, sociology, historical, and psychological approach. Results of this study conclude that curse in Tafsir al-Bayani is composed two aspects, the etymology and terminology. In terms of etymology, curse is true meaning and earnest pronounced by the reciter. As for the aspects of terminology, curse is a verse by way of sensory reasoning. It is diverting attention (la fitah of something that can be felt (Hissi to something abstract. The forms of curse are two, the oath with the letter wau al-qasam and vows with the letter la. The function of curse in al-Tafsir al-Bayani has shifted from its original function of which is to exalt or glorify oath object into a rhetorical aged in which aims to analogize between muqsam bih with Javab al-qasam. Keyword: curse, Bint Syati, interpretation.   Abstrak Tulisan ini membahas topik al-Aqsam fi al-Qur’an (Studi Penafsiran ‘A’isyah bint al-Syati’ dalam Kitab al-Tafsir al-Bayani li al-Qur’an al-Karim tentang Ayat-ayat sumpah. Untuk menjawab permasalahan pokok di atas maka dilakukan penelitian kepustakaan (library research dengan menggunakan pendekatan ilmu tafsir, filologi, sosiologi, historis, dan psikologis. Hasil Penelitian ini menyimpulkan: 1 Hakikat qasam dalam al-Tafsir al-Bayani terdiri dari dua aspek, yaitu etimologi dan terminologi. Dari segi etimologi qasam bermakna sumpah yang benar berbeda dengan kata half yang mengandung arti kebohongan sumpah dan ketidaksungguhan si pengucapnya. Secara terminologi, qasam adalah gaya bahasa dalam al-Qur’an yang menjelaskan makna sebuah ayat dengan cara penalaran indrawi yaitu pengalihan perhatian (lafitah dari sesuatu yang dapat dirasakan (hissi kepada sesuatu yang abstrak. 2 Bentuknya ada dua, yaitu sumpah dengan huruf wau al-qasam dan

  3. Pruning affects the vegetative balance of the wine grape (Vitis vinifera L.

    Directory of Open Access Journals (Sweden)

    Pedro José Almanza-Merchán

    2014-08-01

    Full Text Available Grape cultivation for wine production at altitudes between 2,200 and 2,600 m a.s.l. started in the department of Boyaca in 1982. Quality wines are produced by the AinKarim Vineyard in Ricaurte High. Wine grapes have to possess suitable organoleptic compounds at harvest in order to guarantee quality grape must that can be converted into wine. Therefore, it is necessary to maintain a suitable ratio the sources and the sinks and to guarantee production, quality and vegetative sustainability over time, conserving the equilibrium and benefiting the productive potential of the vineyard. The aim of this study was to evaluate the productive and vegetative balance effect in the wine grape varieties Cabernet Sauvignon and Sauvignon Blanc in Sutamarchan-Boyaca, considering different pruning types (short, long, and mixed. A bifactorial, completely random statistical design was used. At the time of harvest, the fruit production and pruned wood were evaluated. The long-pruned vines showed the best behavior and the most balanced source/sink relationship,, while Sauvignon Blanc demonstrated a better productive yield. Meanwhile, the short and mixed prunings had the better values for the Ravaz index (balance between fruit production and vegetative growth, indicating that they are more suitable for the conditions of the region, allowing for sustainability during the productive cycles of the wine grapes.

  4. The importance of pruning to the quality of wine grape fruits (Vitis vinifera L. cultivated under high-altitude tropical conditions

    Directory of Open Access Journals (Sweden)

    Pedro José Almanza-Merchán

    2014-12-01

    Full Text Available Since 1998, the Ain-Karim Vineyard has been growing different grape varieties for the production of high-altitude tropical wines in the municipality of Sutamarchan, located in the Alto Ricaurte region of Boyaca (Colombia. Pruning is used to limit the number and length of branches, generating a suitable balance between plant vigor and production; thereby, regulating fruit quantity and quality and ensuring reserves for the subsequent production. This study aimed to evaluate the effect of three pruning types (short = two buds on two spurs; long = five buds on three spurs and mixed = combination of short and long pruning types on the fruit quality of V. vinifera, Cabernet Sauvignon and Sauvignon Blanc varieties. To accomplish this, a completely randomized two-factor design was used. Physicochemical variables of fruit quality (fresh cluster weight, water content, total soluble solids (TSS, total titratable acidity (TTA, technical maturity index (TMI, and pH were determined at harvest. The long pruning type presented the highest values for the fresh cluster weight and TSS of the fruits from both varieties and a higher TMI in the Cabernet Sauvignon variety. These results indicate that, under the conditions of the vineyard, long pruning is the most suitable.

  5. Phenological behavior of the grapevine (vitis vinifera l., cv cabernet sauvignon in Sutamarchán - Boyacá.

    Directory of Open Access Journals (Sweden)

    Diana Carolina Vargas Herrera

    2013-12-01

    Full Text Available In tropical cold weather, the grapevine presents phenological disorders, difficult agronomic disfavoring vintage quality. With the purpose of establishing phenological cycles determined the duration of the different phases of the development cycle of the grapevine, cv "Cabernet Sauvignon" (Vitis vinifera L. in the vineyard Ain-Karim (5º39` N, 73º95' W, 2110 masl. We determined the average duration of sprouting (SP, flowering (FL, veraison (VE and vintage (VI periods from pruning, and the total cycle of growth, according to the phenological scale Biologische Bundesanstalt Bundessortenamt Chemise (BBCH. To set the average of the process was considered when the plants reached 50% of each event. Determining growing degree days (GDD support the temperature record by a datalogger. Phenological data were subjected to a descriptive analysis as means and standard deviation. The duration of the period between pruning (PR and vintage (VI, with average temperature of 17.87 ° C, had a duration of 183 days after pruning (DAP, accumulating growing degree days 1458.1 (GDD. Flowering occurred at 50 days after pruning (DAP, accumulating 397.7 GDD. Veraison 122 was presented to the accumulation of 578.2 DAP with GDD. While from veraison to maturity 478.9 GDD accumulated in 62 days. Under Sutamarchán agro-climatic conditions, during the investigation, collects, on average, 7.98 degrees daily growth, which implies that for the Cabernet Sauvignon, the total duration of the phenological cycle is 184 days, accumulating 1458.1 GDD.

  6. Assessment of AquaCrop model in the simulation of durum wheat (Triticum aestivum L. growth and yield under different water regimes in Tadla- Morocco

    Directory of Open Access Journals (Sweden)

    Bassou BOUAZZAM

    2017-09-01

    Full Text Available Simulation models that clarify the effects of water on crop yield are useful tools for improving farm level water management and optimizing water use efficiency. In this study, AquaCrop was evaluated for Karim genotype which is the main durum winter wheat (Triticum aestivum L. practiced in Tadla. AquaCrop is based on the water-driven growth module, in that transpiration is converted into biomass through a water productivity parameter. The model was calibrated on data from a full irrigation treatment in 2014/15 and validated on other stressed and unstressed treatments including rain-fed conditions in 2014/15 and 2015/16. Results showed that the model provided excellent simulations of canopy cover, biomass and grain yield. Overall, the relationship between observed and modeled wheat grain yield for all treatments combined produced an R2 of 0.79, a mean squared error of 1.01 t ha-1 and an efficiency coefficient of 0.68. The model satisfactory predicted the trend of soil water reserve. Consequently, AquaCrop can be a valuable tool for simulating wheat grain yield in Tadla plain, particularly considering the fact that the model requires a relatively small number of input data. However, the performance of the model has to be fine-tuned under a wider range of conditions.

  7. Transcultural Hamlet: Representations of Ophelia and Gertrud in 21st-century Iran

    Directory of Open Access Journals (Sweden)

    Robabeh Jalayer

    2017-01-01

    Full Text Available Multitudes of intermedial Shakespearean adaptations, especially since 1975, have captured Iranian theatrical stage, cinema or radio as the Bard’s texts are frequently modernized, transfigured and indigenized in order to add to his globalization. Hamlet works well in the mechanisms of temporality, spatiality, power, control and sexuality, socio-political discourses, economic upheaval, female self and gender struggles even in the twentieth and twenty-first centuries. Hence, Iranian directors such as Varuzh Karim-Masihi and Arash Dadgar as well as the British director Gregory Doran have re-interpreted this text based on new ideological grounds in which the characters are at times similar or different. In this article, the transformation and characterization of major characters, especially female ones such as Gertrud/Mah-Tal’at and Ophelia/Mahtab, are analyzed based on Hutcheon’s Adaptation Theory to see how they are represented in an Asian society whose Islamic ideology necessitates a unique transcultural, transhistorical rendition.

  8. Neurosurgical strategies for Gilles de la Tourette’s syndrome

    Directory of Open Access Journals (Sweden)

    Karim Mukhida

    2008-09-01

    Full Text Available Karim Mukhida1,2, Matthew Bishop2, Murray Hong2, Ivar Mendez21Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; 2Departments, of Anatomy and Neurobiology and Surgery (Neurosurgery, Dalhousie University, Halifax, Nova Scotia, CanadaAbstract: Tourette’s syndrome (TS is a neurological disorder characterized by motor and vocal tics that typically begin in childhood and often are accompanied by psychiatric comorbidities. Symptoms of TS may be socially disabling and cause secondary medical complications. Pharmacological therapies remain the mainstay of symptom management. For the subset of patients in whom TS symptoms are medically recalcitrant and do not dissipate by adulthood, neurosurgery may offer an alternative treatment strategy. Greater understanding of the neuroanatomic and pathophysiologic basis of TS has facilitated the development of surgical procedures that aim to ameliorate TS symptoms by lesions or deep brain stimulation of cerebral structures. Herein, the rationale for the surgical management of TS is discussed and neurosurgical experiences since the 1960s are reviewed. The necessity for neurosurgical strategies to be performed with appropriate ethical considerations is highlighted.Keywords: tourette’s syndrome, neurosurgery, deep brain stimulation, thalamus

  9. Reducing the iron burden and improving survival in transfusion-dependent thalassemia patients: current perspectives

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    Bayanzay K

    2016-08-01

    Full Text Available Karim Bayanzay, Lama Alzoebie Department of Hematology, Gulf Medical University, Ajman, United Arab Emirates Abstract: Hypertransfusion regimens for thalassemic patients revolutionized the management of severe thalassemia; transforming a disease which previously led to early infant death into a chronic condition. The devastating effect of the accrued iron from chronic blood transfusions necessitates a more finely tuned approach to limit the complications of the disease, as well as its treatment. A comprehensive approach including carefully tailored transfusion protocol, continuous monitoring and assessment of total body iron levels, and iron chelation are currently the mainstay in treating iron overload. There are also indications for ancillary treatments, such as splenectomy and fetal hemoglobin induction. The main cause of death in iron overload continues to be related to cardiac complications. However, since the widespread use of iron chelation started in the 1970s, there has been a general improvement in survival in these patients. Keywords: hematology, chelators, deferoxamine, deferiserox, deferiprone, liver iron concentration, iron overload, serum ferritin concentration, hepatic iron storage, iron chelation therapy

  10. Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation

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    Abdulbaqi IM

    2018-04-01

    Full Text Available Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia Introduction: Colchicine is used for the treatment of gout, pseudo-gout, familial Mediterranean fever, and many other illnesses. Its oral administration is associated with poor bioavailability and severe gastrointestinal side effects. The drug is also known to have a low therapeutic index. Thus to overcome these drawbacks, the transdermal delivery of colchicine was investigated using transethosomal gels as potential carriers.Methods: Colchicine-loaded transethosomes (TEs were prepared by the cold method and statistically optimized using three sets of 24 factorial design experiments. The optimized formulations were incorporated into Carbopol 940® gel base. The prepared colchicine-loaded transethosomal gels were further characterized for vesicular size, dispersity, zeta potential, drug content, pH, viscosity, yield, rheological behavior, and ex vivo skin permeation through Sprague Dawley rats’ back skin.Results: The results showed that the colchicine-loaded TEs had aspherical irregular shape, nanometric size range, and high entrapment efficiency. All the formulated gels exhibited non-Newtonian plastic flow without thixotropy. Colchicine-loaded transethosomal gels were able to significantly enhance the skin permeation parameters of the drug in comparison to the non-ethosomal gel.Conclusion: These findings suggested that the transethosomal gels are promising carriers for the transdermal delivery of colchicine, providing an alternative route for drug administration. Keywords: transethosomes, ethosomal nanocarriers, colchicine, factorial design, skin permeation, rheology

  11. Hessian Fly, Mayetiola destructor (Say, Populations in the North of Tunisia: Virulence, Yield Loss Assessment and Phenological Data Poblaciones de Mosca de Hess, Mayetiola destructor (Say, en el Norte de Túnez: Virulencia, Evaluación de Pérdida de Producción y Datos Fenológicos

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    Hanem Makni

    2011-09-01

    Full Text Available Hessian fly, Mayetiola destructor (Say, is a destructive pest of wheat worldwide and an endemic pest in Tunisia. Two natural populations of this insect from the North of Tunisia were evaluated, in the field, for their virulence, based on response developed by bread wheat (Triticum aestivum L. cultivars carrying H3, H5, H6, H7H8, H11, H13 and H16 resistance genes. H11, H13 and H16 showed a high effectiveness against both populations; therefore, their implication in Hessian fly breeding programs would be of interest. The level of infestation, as well as the yield loss, was assessed, based on the percentage of infested plants and variation in growth parameters due to infestation. The percentage of infested plants, over a 2-yr period in Mateur, averaged 18.82% for durum wheat (Triticum turgidum L. subsp. durum (Desf. Husn. and 32.50% for bread wheat. For the improved durum wheat cv. Karim used as reference, the plant height, number of internodes, number of productive tillers per plant, and 100-seed weight were negatively affected by infestation, while the number of tillers per plant was positively affected. Aiming to update information about the annual number of the fly generations occurring on wheat, we surveyed infestation in Jédéida. At least three Hessian fly generations were detected on bread wheat and durum wheat. Continued regular surveying of Hessian fly populations in terms of virulence, impact on yield and annual generations is required for optimal deployment of resistance genes and integrated management of Hessian fly across all wheat production areas.La mosca de Hess, Mayetiola destructor (Say, es una plaga mundial destructiva del trigo y endémica en Túnez. Se evaluaron dos poblaciones naturales de este insecto desde el Norte de Túnez, en el campo, por su virulencia, basado en la respuesta desarrollada por cultivares de trigo panadero (Triticum aestivum L. portando los genes de resistencia H3, H5, H6, H7H8, H11, H13 y H16. H11, H13

  12. Medical and surgical ward rounds in teaching hospitals of Kuwait University: students’ perceptions

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    AlMutar S

    2013-09-01

    Full Text Available Sara AlMutar,1 Lulwa AlTourah,1 Hussain Sadeq,2 Jumanah Karim,2 Yousef Marwan3 1Department of Medicine, 2Department of Pediatrics, Mubarak Al-Kabeer Hospital, 3Department of Orthopedic Surgery, Al-Razi Orthopedic Hospital, Kuwait City, Kuwait Background: Teaching sessions for medical students during ward rounds are an essential component of bedside teaching, providing students with the opportunity to regard patients as actual people, and to observe their physical conditions directly, allowing a better understanding of illnesses to be developed. We aim to explore medical students’ perceptions regarding medical and surgical ward rounds within the Faculty of Medicine at Kuwait University, and to evaluate whether this teaching activity is meeting the expectation of learners. Methods: A pretested questionnaire was used to collect data from 141 medical students during the 2012–2013 academic year. They were asked to provide their current and expected ratings about competencies that were supposed to be gained during ward rounds, on a scale from 1 (lowest to 5 (highest. Mean scores were calculated, and the Student t-test was used to compare results. P < 0.05 was the cut-off level for significance. Results: Only 17 students (12.1% declined to participate in the study. The students' current competency scores (for competencies taught within both disciplines – medical and surgical were significantly lower than the scores indicating students’ expectations (P < 0.001. The best-taught competency was bedside examination, in both medical (mean: 3.45 and surgical (mean: 3.05 ward rounds. However, medical ward rounds were better than surgical rounds in covering some competencies, especially the teaching of professional attitude and approach towards patients (P < 0.001. Conclusion: Both medical and surgical ward rounds were deficient in meeting the students’ expectations. Medical educators should utilize the available literature to improve the bedside

  13. Sleep-Wake Differences in Relative Regional Cerebral Metabolic Rate for Glucose among Patients with Insomnia Compared with Good Sleepers

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    Kay, Daniel B.; Karim, Helmet T.; Soehner, Adriane M.; Hasler, Brant P.; Wilckens, Kristine A.; James, Jeffrey A.; Aizenstein, Howard J.; Price, Julie C.; Rosario, Bedda L.; Kupfer, David J.; Germain, Anne; Hall, Martica H.; Franzen, Peter L.; Nofzinger, Eric A.; Buysse, Daniel J.

    2016-01-01

    Study Objectives: The neurobiological mechanisms of insomnia may involve altered patterns of activation across sleep-wake states in brain regions associated with cognition, self-referential processes, affect, and sleep-wake promotion. The objective of this study was to compare relative regional cerebral metabolic rate for glucose (rCMRglc) in these brain regions across wake and nonrapid eye movement (NREM) sleep states in patients with primary insomnia (PI) and good sleeper controls (GS). Methods: Participants included 44 PI and 40 GS matched for age (mean = 37 y old, range 21–60), sex, and race. We conducted [18F]fluoro-2-deoxy-d-glucose positron emission tomography scans in PI and GS during both morning wakefulness and NREM sleep at night. Repeated measures analysis of variance was used to test for group (PI vs. GS) by state (wake vs. NREM sleep) interactions in relative rCMRglc. Results: Significant group-by-state interactions in relative rCMRglc were found in the precuneus/posterior cingulate cortex, left middle frontal gyrus, left inferior/superior parietal lobules, left lingual/fusiform/occipital gyri, and right lingual gyrus. All clusters were significant at Pcorrected sleep and wakefulness. Significant group-by-state interactions in relative rCMRglc suggest that insomnia is associated with impaired disengagement of brain regions involved in cognition (left frontoparietal), self-referential processes (precuneus/posterior cingulate), and affect (left middle frontal, fusiform/lingual gyri) during NREM sleep, or alternatively, to impaired engagement of these regions during wakefulness. Citation: Kay DB, Karim HT, Soehner AM, Hasler BP, Wilckens KA, James JA, Aizenstein HJ, Price JC, Rosario BL, Kupfer DJ, Germain A, Hall MH, Franzen PL, Nofzinger EA, Buysse DJ. Sleep-wake differences in relative regional cerebral metabolic rate for glucose among patients with insomnia compared with good sleepers. SLEEP 2016;39(10):1779–1794. PMID:27568812

  14. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

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    Abdulbaqi IM

    2016-05-01

    Full Text Available Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi, Arshad A Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Abstract: Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/ transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential, entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems. Keywords: ethosomes, transdermal, lipid-based vesicles, delivery systems

  15. Hummingbird Ecstasy footprint and cultural guide for vine and wine. The case of "Marqués of Villa de Leyva"

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    Fabio Aldemar Gómez Sierra

    2012-10-01

    Full Text Available In this article reflecting on viticulture in Boyacá, is analyzed from the project and its product Ain Karim wine Marqués de Villa de Leyva, located in the Valley of Zaquencipá, a structured system of meanings that this type of agriculture does unite in place where it is installed. Historically, viticultural practices have managed to involve substantial elements of cultural dynamics: belief systems, identity, health and disease, and ways to socialize economy ingesting fermented beverages. The wine "Marquis of Villa de Leyva" emerges in a context of climate, soil and subsoil, with potential for development characteristics, which however must be certified with specialized studies of tropical modern winemaking. In this Zaquencipá Valley, as it was called ancestrally, the religious geosmbólica was irradiated by Iguaquemountains, sacred space Muiscas. The conquest and colonization transformed it by the Christian geosimbólica, economic (production of wheat and military. Currently the town of Villa de Leyva and his environment is attractive to tourists, middle-class residents and significant capital, in this context arises the Vineyard founded in the early eighties by Mr. Pablo Toro, originally imported strains Cabernet Sauvignon, Chardonnay and Sauvignon Blanc. This replicates the culture of the vine and wine, which is also supported by a constant of aesthetics, hygiene and ethno-specific technical. its process leaves substantial perceive elements of cultural globalization, internationalization and localities need to analyze the ethno-regional production techniques.

  16. Comparing the effects of epidural methylprednisolone acetate injected in patients with pain due to lumbar spinal stenosis or herniated disks: a prospective study

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    Gharibi F

    2011-12-01

    Full Text Available Jafar Mobaleghi1, Faramarz Allahdini2, Karim Nasseri3, Behzad Ahsan3, Shoaleh Shami4, Mansour Faizi5, Fardin Gharibi51Department of Surgery, 2Department of Neurosurgery, 3Department of Anesthesia, 4Faculty of Nursing, 5Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Kurdistan, IranObjective: Satisfactory results have been seen with epidural steroid injections (ESI in patients with herniated disks (HD, but the role in lumbar spinal stenosis (LSS has been less investigated. We compared long-term effects of ESI in HD and LSS patients.Methods: In a prospective, single-blind uncontrolled study, 60 patients with radicular pain due to HD (n = 32 or LSS (n = 28 were enrolled over a 9-month period. Methylprednisolone acetate 80 mg plus 0.5% bupivacaine 10 mg were diluted in normal saline up to a total volume of 10 mL, and injected into the epidural space. The amount of pain based on numeric pain score, level of activity, and subjective improvement were reported by patients after 2 and 6 months by telephone. Demographic data were analyzed with the chi-square test. The differences in numeric pain scale scores between the two groups at different times were analyzed with the t-test.Results: There were no differences between HD and LSS patients regarding age, sex, and average duration of pain prior to ESI. The degree of pain was significantly higher in LSS patients in comparison with HD patients in the pre-injection period. The amount of pain was significantly reduced in both groups 2 months after injection. This pain reduction period lasted for 6 months in the HD group, but to a lesser extent in LSS patients (P < 0.05.Discussion: Epidural methylprednisolone injection has less analgesic effect in LSS, with less permanent effect in comparison with HD.Keywords: methylprednisolone acetate, lumbar spinal stenosis, herniated disk

  17. The impact of using musculoskeletal ultrasound imaging and other influencing factors on medication adherence in patients with rheumatoid arthritis: a qualitative study

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    Kumar K

    2016-06-01

    Full Text Available Kanta Kumar,1,2 Karim Raza,3,4 Paramjit Gill,1 Sheila Greenfield1 1Primary Care Clinical Sciences, University of Birmingham, Birmingham, 2Faculty of Medical and Human Sciences, University of Manchester, Manchester, 3Institute of Inflammation and Ageing, University of Birmingham, 4Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK Background: Medication can ease symptoms and limit disease progression in rheumatoid arthritis (RA. Despite this, nonadherence to medication is common in RA. We explored the determinants of high and low adherence to disease-modifying antirheumatic drugs (DMARDs in patients with RA and provide suggestions on approaches to improving adherence to DMARDs.Methods: Patients with RA were identified from those who had previously participated in a questionnaire measuring levels of medication adherence. Twenty patients participated (ten high and ten low adherers, as determined by responses to the Medication Adherence Report Scale. In-depth individual semistructured interviews were undertaken until data saturation was reached. Interviews were transcribed and analyzed using a constant comparative method.Results: Four main themes related to adherence were identified: 1 symptom severity; 2 illness perception; 3 perceived benefits and risks of DMARDs; and 4 the quality and quantity of information about RA and DMARDs. In addition, patients’ suggestions about strategies to optimize adherence to DMARDs were captured and they fell within the following themes: 1 musculoskeletal ultrasound to explain the disease process and to provide objective feedback about the extent to which their disease activity is being effectively controlled; 2 better explanations of the consequences of poorly controlled RA; and 3 a good relationship with the health professional.Conclusion: Patients’ beliefs about medicines, perceptions about RA, and level of satisfaction with information about DMARDs influenced their adherence to DMARDs. The use

  18. Effects of copper sulfate-oxidized or myeloperoxidase- modified LDL on lipid loading and programmed cell death in macrophages under hypoxia

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    Vlaminck B

    2014-09-01

    Full Text Available Benoit Vlaminck,1 Damien Calay,1 Marie Genin,1 Aude Sauvage,1 Noelle Ninane,1 Karim Zouaoui Boudjeltia,2 Martine Raes,1 Carine Michiels1 1Laboratory of Biochemistry and Cellular Biology (URBC, Namur Research Institute for Life Sciences (NARILIS, University of Namur, Namur, Belgium; 2Laboratory of Experimental Medicine (ULB 222 Unit, Universite Libre de Bruxelles, CHU de Charleroi, Charleroi, Belgium Abstract: Atheromatous plaques contain heavily lipid-loaded macrophages that die, hence generating the necrotic core of these plaques. Since plaque instability and rupture is often correlated with a large necrotic core, it is important to understand the mechanisms underlying foam cell death. Furthermore, macrophages within the plaque are associated with hypoxic areas but little is known about the effect of low oxygen partial pressure on macrophage death. The aim of this work was to unravel macrophage death mechanisms induced by oxidized low-density lipoproteins (LDL both under normoxia and hypoxia. Differentiated macrophages were incubated in the presence of native, copper sulfate-oxidized, or myeloperoxidase-modified LDL. The unfolded protein response, apoptosis, and autophagy were then investigated. The unfolded protein response and autophagy were triggered by myeloperoxidase-modified LDL and, to a larger extent, by copper sulfate-oxidized LDL. Electron microscopy observations showed that oxidized LDL induced excessive autophagy and apoptosis under normoxia, which were less marked under hypoxia. Myeloperoxidase-modified LDL were more toxic and induced a higher level of apoptosis. Hypoxia markedly decreased apoptosis and cell death, as marked by caspase activation. In conclusion, the cell death pathways induced by copper sulfate-oxidized and myeloperoxidase-modified LDL are different and are differentially modulated by hypoxia. Keywords: Ox-LDL, myeloperoxidase, hypoxia, UPR, apoptosis, autophagy, macrophages

  19. Generic Skills from Qur'anic Perspective

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    Siddig Ahmad

    2012-06-01

    Full Text Available Generic skills are defined as a set of skills that are directly related and needed for the working environment. Employers prefer to recruit officials who are competent in interpersonal communication, leadership skill, team work, oral and written skills. They are reluctant to employ graduates lacking certain necessary skills. This reveals the fact that there is a serious gap between the skills that are required by the employers and the skills that the graduates possess. Therefore, this research is focused on five aspects of generic skills namely; communication, team work, problem solving, lifelong learning and self-esteem. From Qur’anic perspective, the same terms have been used except minor differences in using various terms. The thematic approach is used when discussing these aspects from the Qur’an. The findings showed that the ways of effective communication are represented by terms of qawl sadid, qawl ma`ruf, qawl baligh, qawl maysur, qawl karim and qawl layyin. For collective work, ta`aruf and tafahum, as the pre-requisites, should be practiced via ta`awun and takaful. For problem solving, four methods are adapted from the Qur’an such as reflection of the past, observation, demonstration and asking questions. For lifelong learning, the establishment of learning institutions and the self-motivation of learners are two pre-requisites that should be undertaken for its accomplishment. They could be practiced through open learning system, consultation and hands-on learning. Last but not least, for personality development could be built up through physical training, spiritual training and mental training.

  20. Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma

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    Faiena I

    2018-01-01

    Full Text Available Izak Faiena,1,2 Amy L Cummings,3 Anna M Crosetti,3 Allan J Pantuck,1,2 Karim Chamie,1,2 Alexandra Drakaki1–3 1Department of Urology, 2Institute of Urologic Oncology, 3Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA Abstract: Our expanding knowledge of immunotherapy for solid tumors has led to an explosion of clinical trials aimed at urothelial carcinoma. The primary strategy is centered on unleashing the immune system by releasing the inhibitory signals propagated by programmed cell death-1 (PD-1 and its ligand programmed cell death ligand-1 (PD-L1. Many antibody constructs have been developed to block these interactions and are used in clinical trials. The Food and Drug Administration has already approved a number of checkpoint inhibitors such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4 monoclonal antibodies including ipilimumab; anti-PD-1 monoclonal antibodies including nivolumab and pembrolizumab; anti-PD-L1 antibodies including atezolizumab, avelumab, and durvalumab. One of the latest inhibitors is durvalumab, which is a high-affinity human immunoglobulin G1 kappa monoclonal antibody and blocks the interaction of PD-L1 with PD-1 and CD80. Currently, there are a number of ongoing trials in advanced urothelial carcinoma both using durvalumab monotherapy and in combination with other targeted therapies. In addition, durvalumab is being investigated in the non-muscle-invasive urothelial carcinoma, which is centered around intravenous formulations. These exciting developments have added a significant number of therapies in a previously limited treatment landscape. Keywords: durvalumab, checkpoint inhibitors, metastatic urothelial carcinoma

  1. Increased theta band EEG power in sickle cell disease patients

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    Case M

    2017-12-01

    Full Text Available Michelle Case,1 Sina Shirinpour,1 Huishi Zhang,1 Yvonne H Datta,2 Stephen C Nelson,3 Karim T Sadak,4 Kalpna Gupta,2 Bin He1,5 1Department of Biomedical Engineering, 2Department of Medicine, University of Minnesota, 3Pediatric Hematology-Oncology, Children’s Hospitals and Clinics of Minnesota, 4Pediatric Hematology-Oncology, University of Minnesota Masonic Children’s Hospital, 5Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN, USA Objective: Pain is a major issue in the care of patients with sickle cell disease (SCD. The mechanisms behind pain and the best way to treat it are not well understood. We studied how electroencephalography (EEG is altered in SCD patients. Methods: We recruited 20 SCD patients and compared their resting state EEG to that of 14 healthy controls. EEG power was found across frequency bands using Welch’s method. Electrophysiological source imaging was assessed for each frequency band using the eLORETA algorithm. Results: SCD patients had increased theta power and decreased beta2 power compared to controls. Source localization revealed that areas of greater theta band activity were in areas related to pain processing. Imaging parameters were significantly correlated to emergency department visits, which indicate disease severity and chronic pain intensity. Conclusion: The present results support the pain mechanism referred to as thalamocortical dysrhythmia. This mechanism causes increased theta power in patients. Significance: Our findings show that EEG can be used to quantitatively evaluate differences between controls and SCD patients. Our results show the potential of EEG to differentiate between different levels of pain in an unbiased setting, where specific frequency bands could be used as biomarkers for chronic pain. Keywords: sickle cell disease, electroencephalography, chronic pain, electrophysiological source imaging, thalamocortical dysrhythmia

  2. Inter-Faith Reading of Perfect Man With Mystical Approach

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    Fatemeh Musavi

    2010-12-01

    Full Text Available The expression Insan –e kamil (perfect man is often said to have first been used by Muhyiddin ibn 'Arabi (1165 -1240AD, though the concept of the term is much older. In his theosophical teaching, the doctrine of insan e- kamil, is held a prominent place. After him two other great Sufis, Aziz Nasafi (1300AD and 'Abd al- karim ibn Ibrahim al- Jili (1366 – 1424 AD, each wrote a work on this very issue. These works are regarded as explanations of Ibn Arabi’s teachings on human perfection. In Islamic mysticism, Perfect man is the one who within their soul possesses all God's names and attributes. Thus the perfect man’s existence, reality and inner might become a clear mirror and a complete reflection of the Perfection, Beauty and Glory of the Essence of the One, so that he becomes Godlike. However, the idea of human perfectibility going back to other religions and human schools even before Islam. In Abrahimic religions there are some joint teachings that could be considered as main statements for the doctrine of Perfect Man In Jewish scriptures the notion of human creation in God's image suggests that the human being is able to be God's like and the perfection is available to him. However, Jews do not believe a perfect man. They hold that even Moses is not a perfect man. In Christianity, Although Jesus encourages his followers to be perfect like their heavenly fathers, the doctrine of original sin to be considered as an obstacle for human perfectibility.This essay examines some significant element in human perfectibility from the view points of some scholars of Judaism, Christianity and Islam and presents some similarities and differences of their view points.

  3. Inter-Faith Reading of Perfect Man With Mystical Approach

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    Mohammadkazem Shaker

    2011-01-01

    Full Text Available   The expression Insan –e kamil (perfect man is often said to have first been used by Muhyiddin ibn 'Arabi (1165 -1240AD, though the concept of the term is much older. In his theosophical teaching, the doctrine of insan e- kamil, is held a prominent place. After him two other great Sufis, Aziz Nasafi (1300AD and 'Abd al- karim ibn Ibrahim al- Jili (1366 – 1424 AD, each wrote a work on this very issue. These works are regarded as explanations of Ibn Arabi’s teachings on human perfection. In Islamic mysticism, Perfect man is the one who within their soul possesses all God's names and attributes. Thus the perfect man’s existence, reality and inner might become a clear mirror and a complete reflection of the Perfection, Beauty and Glory of the Essence of the One, so that he becomes Godlike. However, the idea of human perfectibility going back to other religions and human schools even before Islam. In Abrahimic religions there are some joint teachings that could be considered as main statements for the doctrine of Perfect Man In Jewish scriptures the notion of human creation in God's image suggests that the human being is able to be God's like and the perfection is available to him. However, Jews do not believe a perfect man. They hold that even Moses is not a perfect man. In Christianity, Although Jesus encourages his followers to be perfect like their heavenly fathers, the doctrine of original sin to be considered as an obstacle for human perfectibility.This essay examines some significant element in human perfectibility from the view points of some scholars of Judaism, Christianity and Islam and presents some similarities and differences of their view points.

  4. Inter-Faith Reading of Perfect Man With Mystical Approach

    Directory of Open Access Journals (Sweden)

    Shaker, M.K

    2011-01-01

    Full Text Available The expression Insan –e kamil (perfect man is often said to have first been used by Muhyiddin ibn 'Arabi (1165 -1240AD, though the concept of the term is much older. In his theosophical teaching, the doctrine of insan e- kamil, is held a prominent place. After him two other great Sufis, Aziz Nasafi (1300AD and 'Abd al- karim ibn Ibrahim al- Jili (1366 – 1424 AD, each wrote a work on this very issue. These works are regarded as explanations of Ibn Arabi’s teachings on human perfection. In Islamic mysticism, Perfect man is the one who within their soul possesses all God's names and attributes. Thus the perfect man’s existence, reality and inner might become a clear mirror and a complete reflection of the Perfection, Beauty and Glory of the Essence of the One, so that he becomes Godlike. However, the idea of human perfectibility going back to other religions and human schools even before Islam. In Abrahimic religions there are some joint teachings that could be considered as main statements for the doctrine of Perfect Man In Jewish scriptures the notion of human creation in God's image suggests that the human being is able to be God's like and the perfection is available to him. However, Jews do not believe a perfect man. They hold that even Moses is not a perfect man. In Christianity, Although Jesus encourages his followers to be perfect like their heavenly fathers, the doctrine of original sin to be considered as an obstacle for human perfectibility.This essay examines some significant element in human perfectibility from the view points of some scholars of Judaism, Christianity and Islam and presents some similarities and differences of their view points.

  5. Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Nasseri K

    2017-04-01

    Full Text Available Karim Nasseri,1,2 Negin Ghadami,1 Bijan Nouri2 1Department of Anesthesiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran; 2Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran Background: Shivering is among the common troublesome complications of spinal anesthesia (SA, and causes discomfort and discontentment in parturients undergoing cesarean sections (CSs. The aim of this study was to investigate the effects of intrathecal dexmedetomidine in the prevention of shivering in those who underwent CS under SA.Subjects and methods: Fifty parturients planned for elective CSs under SA were enrolled in this prospective, double-blinded, controlled study and randomly divided into two equal groups. Spinal block was achieved with 12.5 mg 0.5% heavy bupivacaine plus 5 µg dexmedetomidine (BD group or 0.5 mL 0.9% normal saline (BN group. The incidence and intensity of shivering, peripheral and core body temperature, hemodynamic parameters, and adverse events was recorded.Results: The incidence of shivering was significantly higher in the BN group (52% than the BD group (24% (P=0.04. Likewise, the intensity of shivering was significantly higher in the BN group than the BD group (P=0.04. The incidence of adverse events, such as hypotension, nausea/vomiting, and bradycardia, was not significantly different between the two groups, although the grade of sedation was higher in the BD group than the BN group (P=0.004.Conclusion: We conclude that intrathecal dexmedetomidine is effective in lowering the incidence and intensity of shivering in parturients undergoing CSs under SA without major adverse effects. Keywords: dexmedetomidine, shivering, spinal anesthesia, cesarean sections, bupivacaine

  6. Echoes from a Dying Star

    Science.gov (United States)

    Kohler, Susanna

    2017-06-01

    When a passing star is torn apart by a supermassive black hole, it emits a flare of X-ray, ultraviolet, and optical light. What can we learn from the infrared echo of a violent disruption like this one?Stellar DestructionOptical (black triangles) and infrared (blue circles and red squares) observations of F010042237. Day 0 marks the day the optical emission peaked. The infrared emission rises steadily through the end of the data. [Dou et al. 2017]Tidal disruption events occur when a star passes within the tidal radius of a supermassive black hole. After tidal forces pull the star apart, much of the stellar matter falls onto the black hole, radiating briefly in X-ray, ultraviolet and optical as it accretes. This signature rise and gradual fall of emission has allowed us to detect dozens of tidal disruption events thus far.One of the recently discovered candidate events is a little puzzling. Not only does the candidate in ultraluminous infrared galaxy F010042237 have an unusual host most disruptions occur in galaxies that are no longer star-forming, in contrast to this one but its optical light curve also shows an unusually long decay time.Now mid-infrared observations of this event have beenpresented by a team of scientists led by Liming Dou (Guangzhou University and Department of Education, Guangdong Province, China), revealing why this disruption is behaving unusually.Schematic of a convex dusty ring (red bows) that absorbs UV photons and re-emits in the infrared. It simultaneously scatters UV and optical photons into our line of sight. The dashed lines illustrate the delays at lags of 60 days, 1, 2, 3, 4, and 5 years. [Adapted from Dou et al. 2017]A Dusty Solution?The optical flare from F010042237s nucleus peaked in 2010, so Dou and collaborators obtained archival mid-infrared data from the WISE and NEOWISE missions from 2010 to 2016. The data show that the galaxy is quiescent in mid-infrared in 2010 but in data from three years later, the infrared emission has

  7. Plantinga\\\\\\'s Internal and External Approach toRationality of Belief in God

    Directory of Open Access Journals (Sweden)

    Mahdi Farajipak

    2015-03-01

    Full Text Available Various views about the rationality/irrationality of believing in God have been suggested by western religious and secular thinners. The theory of "Basicalism" together with its similar views such as "Evidentialism", "Fideism" and"Pragmatism" is one of the epistemological views posed about the belief in God and seeks to prove its rationality. In general, based on this view, believing in God does not require any rational reasoning. Various versions of this view have been presented so far.One of its versions expressed by scholars like Swinburne, Alston and Plantinga is what is known as Experientialism. In his special exposition of Experientialism – which he refers to as "reformed epistemology" –Plantinga has had two different dictions in his works. In his early woks such as God and other Minds, "Is Belief in God Rational?", "Is Belief in God Properly Basic?" and"Reformed Epistemology and Christian Apologetics", he endeavored to prove the rationality and justificationof believing in God and tried to offer certain and compelling arguments to prove the existence of God. In these works, Plantinga has adopted an internal approach toward the rationality of believing in God and regards it as a basic belief. Criticizing classic foundationalism, he sought to expand a different version of foundationalism according to which God's existence is regarded as basic for a believer. Based on this approach, Palntinga, like other proponents of foundationalism, considers the knowledgea "True Justified Belief". His view is, however, different from other foundationalists in defining the nature of the third element of knowledge. According to Plantinga's early exposition of his theory, the criteria of rationality of believing in God include the principles of classic foundationalism(such as evident to senses, evident to reason and incorrigibility and other elements. He rejected the deductive-priori method concerning the criteria of determining basic belief and

  8. Plantinga's Internal and External Approach toRationality of Belief in God

    Directory of Open Access Journals (Sweden)

    Mahdi Farajipak

    2015-02-01

    Full Text Available Various views about the rationality/irrationality of believing in God have been suggested by western religious and secular thinners. The theory of "Basicalism" together with its similar views such as "Evidentialism", "Fideism" and"Pragmatism" is one of the epistemological views posed about the belief in God and seeks to prove its rationality. In general, based on this view, believing in God does not require any rational reasoning. Various versions of this view have been presented so far.One of its versions expressed by scholars like Swinburne, Alston and Plantinga is what is known as Experientialism. In his special exposition of Experientialism – which he refers to as "reformed epistemology" –Plantinga has had two different dictions in his works. In his early woks such as God and other Minds, "Is Belief in God Rational?", "Is Belief in God Properly Basic?" and"Reformed Epistemology and Christian Apologetics", he endeavored to prove the rationality and justificationof believing in God and tried to offer certain and compelling arguments to prove the existence of God. In these works, Plantinga has adopted an internal approach toward the rationality of believing in God and regards it as a basic belief. Criticizing classic foundationalism, he sought to expand a different version of foundationalism according to which God's existence is regarded as basic for a believer. Based on this approach, Palntinga, like other proponents of foundationalism, considers the knowledgea "True Justified Belief". His view is, however, different from other foundationalists in defining the nature of the third element of knowledge. According to Plantinga's early exposition of his theory, the criteria of rationality of believing in God include the principles of classic foundationalism(such as evident to senses, evident to reason and incorrigibility and other elements. He rejected the deductive-priori method concerning the criteria of determining basic belief and

  9. Prevalence of Listeria monocytogenes in traditional ice cream, Yazd, IRAN (1394 and compared to other studies in different parts of Iran

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    Negar Hamidian

    2017-07-01

    Full Text Available 1-Mortazavi S, Gods rohani M, Juyande H. milk and dairy products technology. The University Ferdowsi Mashhad; 1996. p. 266. 2-Azadnia P, Ghasemi M, Abbasi M, Taarof N, Jashni M. Microbial Quality of Traditional Ice Cream Produced by Small-Scale Manufacturers in Khormoj and Its Comparison with the Iranian National Standard. Journal of Animal and Veterinary Advances 2011;10(6:742-4. 3- Ziabari Mirnezami H. What do you know about milk (Milk chemical technology: Tehran University; 1996. 4-Movassagh MH, Movassagh A, Mahmoodi H, Servatkhah F, Sourorbakhsh MR. Microbiological contamination of the traditional chocolate Ice cream sold in the Northwest Region of Iran. Global Veterinaria 2011;6(3:269-71. 5-Karim G, Razavilar V, Akhonndzade A. survey contamination of traditional ice cream to bacteria causing the infection and food poisoning[persian]. Tehran University Faculty of Veterinary 1374;50:71-8. 6-Kanbakan U, Con A, Ayar A. Determination of microbiological contamination sources during ice cream production in Denizli, Turkey. Food Control 2004;15(6:463-70. 7- Fallah AA, Saei-Dehkordi SS, Rahnama M, Tahmasby H, Mahzounieh M. Prevalence and antimicrobial resistance patterns of  Listeria  species isolated from poultry products marketed in Iran. Food Control 2012;28(2:327-32. 8-Farber J, Peterkin P. Listeria monocytogenes, a food-borne pathogen. Microbiological reviews 1991;55(3:476. 9-Navratilova P, Schlegelova J, Sustackova A, Napravnikova E, Lukasova J, Klimova E. Prevalence of Listeria monocytogenes in milk, meat and foodstuff of animal origin and the phenotype of antibiotic resistance of isolated strains. Veterinarni Medicina-UZPI 2004;49. 10-Williams SK, Roof S, Boyle EA, Burson D, Thippareddi H, Geornaras I, et al. Molecular ecology of Listeria monocytogenes and other Listeria species in small and very small ready-to-eat meat processing plants. J Food Prot 2011;74(1:63-77. 11-Halter E, Neuhaus K, Scherer S. Listeria weihenstephanensis sp. nov

  10. The educational environment of the undergraduate medical curriculum at Kuwait University

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    Karim J

    2015-04-01

    Full Text Available Jumanah Karim,1 Becher Al-Halabi,2 Yousef Marwan,3 Hussain Sadeq,4 Ahmed Dawas,5 Dalia Al-Abdulrazzaq5 1Department of Pediatrics, Al-Amiri Hospital, Kuwait City, Kuwait; 2Department of Surgery, Mubarak Al-Kabeer Hospital, Kuwait City, Kuwait; 3Department of Orthopaedic Surgery, Al-Razi Orthopaedic Hospital, Kuwait City, Kuwait; 4Department of Pediatrics, Al-Adan Hospital, Kuwait City, Kuwait; 5Department of Pediatrics, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait City, Kuwait Background: Educational environment of an institution affects the quality of learning. We aim to assess the educational environment of the undergraduate curriculum of Faculty of Medicine, Kuwait University (FOMKU. Methods: A cross-sectional study was carried out during April 2014. The validated Dundee Ready Education Environment Measure (DREEM questionnaire was e-mailed to 607 students. Mean scores of the main domains of the questionnaire, and for each item, were calculated, and their association with the students’ background information was measured using Student’s t-test (P-value of ≤0.05 was considered as the cut-off level of significance. Results: Of 607 students, 117 (19.3% completed the questionnaire. The total mean score for DREEM was 108.7/200 (54.3%. The mean score for students’ perception of teaching, perception of teachers, academic self-perception, perception of atmosphere, and social self-perception were 25.2/48 (52.5%, 24.6/44 (55.9%, 18.4/32 (57.5%, 26.2/48 (54.5%, and 14.3/28 (51.0%, respectively. The highest mean score for an item of DREEM questionnaire was for “my accommodation is pleasant” (3.48±0.75, while the lowest was for “there is a good support system for students who get stressed” (0.88±0.86. The total mean score was not significantly different between the two phases of the curriculum, or among males and females; however, few significant differences among the main domains and items were noted. Conclusion

  11. Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis

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    Karim R

    2013-06-01

    Full Text Available Rushmia Karim,1 Evripidis Sykakis,2 Susan Lightman,3 Samantha Fraser-Bell4 1Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia; 2Department of Ophthalmology, Whipps Cross University Hospital, 3UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, UK; 4University of Sydney, Clinical Ophthalmology and Eye Health, Sydney Adventist Hospital Clinical School, Sydney, NSW, Australia Background: Uveitic macular edema is the major cause of reduced vision in eyes with uveitis. Objectives: To assess the effectiveness of interventions in the treatment of uveitic macular edema. Search strategy: Cochrane Central Register of Controlled Trials, Medline, and Embase. There were no language or data restrictions in the search for trials. The databases were last searched on December 1, 2011. Reference lists of included trials were searched. Archives of Ophthalmology, Ophthalmology, Retina, the British Journal of Ophthalmology, and the New England Journal of Medicine were searched for clinical trials and reviews. Selection criteria: Participants of any age and sex with any type of uveitic macular edema were included. Early, chronic, refractory, or secondary uveitic macular edema were included. We included trials that compared any interventions of any dose and duration, including comparison with another treatment, sham treatment, or no treatment. Data collection and analysis: Best-corrected visual acuity and central macular thickness were the primary outcome measures. Secondary outcome data including adverse effects were collected. Conclusion: More results from randomized controlled trials with long follow-up periods are needed for interventions for uveitic macular edema to assist in determining the overall long-term benefit of different treatments. The only intervention with sufficiently robust randomized controlled trials for a meta-analysis was acetazolamide, which was shown to be ineffective in improving vision in eyes with uveitic

  12. A multicenter controlled study for dementia prevention through physical, cognitive and social activities – GESTALT-kompakt

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    Streber A

    2017-12-01

    Full Text Available Anna Streber, Karim Abu-Omar, Christian Hentschke, Alfred Rütten Department of Sport Science and Sport, Faculty of Humanities, Social Sciences, and Theology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany Abstract: Prevention of dementia is a public health priority. Physical activity (PA can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years. We hypothesized that an evidence-based PA intervention – GEhen, Spielen und Tanzen Als Lebenslange Tätigkeiten – kompakt [walking, playing and dancing as lifelong activities-compact] (GESTALT-kompakt – would lead to significantly larger improvements in PA levels (step counts/Fitbit Zip™, cognitive functions (DemTect and social activities (Social Activity Log, compared to an active control group. Data were collected at baseline and after 3 and 12 months. The intervention group received a 12-week (1/week multimodal and multicomponent PA program, which combined PA with cognitive and social activities. The control group received either regular gymnastics or cognitive training (1/week. A mixed linear model was chosen for analysis. A total of 87 older individuals were recruited in the GESTALT-kompakt study (68 females, average age =76.0 years, SD ±9.2, range 52–95 years. Marginally significant differences were observed in the intervention group (n=57 in comparison to the control group (n=30, regarding improvements in PA (difference of mean changes =866.4 steps, p=0.055 after 3 months. However, their PA decreased to the baseline score value after 12 months (-866.0 steps, p=0.061. GESTALT-kompakt did not cause significant differences in cognitive functioning (-0.8620, p=0.074 and social activities (-0.2428, p=0.288 in comparison to the control intervention from T0 to T1. Sixteen (24.2% study participants who finished T2 reported a negative life event during the follow-up period

  13. Clinical development of galunisertib (LY2157299 monohydrate, a small molecule inhibitor of transforming growth factor-beta signaling pathway

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    Herbertz S

    2015-08-01

    Full Text Available Stephan Herbertz,1 J Scott Sawyer,2 Anja J Stauber,2 Ivelina Gueorguieva,3 Kyla E Driscoll,4 Shawn T Estrem,2 Ann L Cleverly,3 Durisala Desaiah,2 Susan C Guba,2 Karim A Benhadji,2 Christopher A Slapak,2 Michael M Lahn21Lilly Deutschland GmbH, Bad Homburg, Germany; 2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 3Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK; 4Lilly Research Laboratories, Eli Lilly and Company, New York, NY, USA Abstract: Transforming growth factor-beta (TGF-β signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks of cancer, including tumor proliferation, invasion and metastasis, inflammation, angiogenesis, and escape of immune surveillance. There are several pharmacological approaches to block TGF-β signaling, such as monoclonal antibodies, vaccines, antisense oligonucleotides, and small molecule inhibitors. Galunisertib (LY2157299 monohydrate is an oral small molecule inhibitor of the TGF-β receptor I kinase that specifically downregulates the phosphorylation of SMAD2, abrogating activation of the canonical pathway. Furthermore, galunisertib has antitumor activity in tumor-bearing animal models such as breast, colon, lung cancers, and hepatocellular carcinoma. Continuous long-term exposure to galunisertib caused cardiac toxicities in animals requiring adoption of a pharmacokinetic/pharmacodynamic-based dosing strategy to allow further development. The use of such a pharmacokinetic/pharmacodynamic model defined a therapeutic window with an appropriate safety profile that enabled the clinical investigation of galunisertib. These efforts resulted in an intermittent dosing regimen (14 days on/14 days off, on a 28-day cycle of galunisertib for all ongoing trials. Galunisertib is being investigated either as monotherapy or in combination with standard antitumor regimens (including nivolumab

  14. Rationale, design, and cohort enrolment of a prospective observational study of the clinical performance of the new contraceptive implant (Femplant in Pakistan

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    Azmat SK

    2014-05-01

    Full Text Available Syed Khurram Azmat,1 Waqas Hameed,1 Anja Lendvay,2 Babar Tasneem Shaikh,3 Ghulam Mustafa,1 Muhammad Ahmed Siddiqui,1 Sajid Brohi,1 Asif Karim,1 Muhammad Ishaque,1 Wajahat Hussain,1 Mohsina Bilgrami,1 Paul J Feldblum2 1Research, Monitoring and Evaluation Department, Marie Stopes Society, Karachi, Pakistan; 2FHI 360, Durham, NC, USA; 3Health Services Academy, Islamabad, Pakistan Introduction: The use of hormonal implants has gained positive traction in family planning programs in recent times. Compared to other popular methods, such as long-term reversible intrauterine devices, the use of hormonal implants as a family planning method has distinct advantages in terms of long-term efficiency and better user compliance and availability. This paper presents a study protocol to document and evaluate the efficacy, safety, and acceptability of Femplant (contraceptive implant in Pakistan during the first year of its use among married women of reproductive age (18–44 years at clinics in two provinces of Pakistan (Sindh and Punjab. Materials and methods: A total of 724 married women were enrolled in a noncomparative prospective observational study. The study involved six government clinics from the Population Welfare Department in Sindh Province and 13 clinics run by the Marie Stopes Society (a local nongovernmental organization in both provinces. The participation of women was subject to voluntary acceptance and medical eligibility. All respondents were interviewed at baseline and subsequently at each scheduled visit during the study period. Side effects, complications and adverse events, if any, were recorded for every participant at each visit to the facility. Discussion: Over the next 5-year period (2013–2018, 27 million hormonal implants will be made available in lower- to middle-income countries by international donors and agencies. The evidence generated from this study will identify factors affecting the acceptability and satisfaction of end

  15. Radiation protection of workers in radiological emergency situation. Proceedings of the technical day

    International Nuclear Information System (INIS)

    Rannou, Alain; Gosset, Eric; Lahaye, Thierry; Foucher, Laurent; Couasnon, Olivier; Bouchery, Pascal; Gaillard-Lecanu, Emmanuelle; Pectorin, Xavier; Fusil, Laurence; Boudergui, Karim; Adhemar, Bruno; Devin, Patrick; Mace, Jean-Reynald; Chevallier, Michel; Leautaud, Jean-Marc; LANCE, Benoit

    2015-03-01

    interest group (Michel CHEVALLIER, Jean-Marc LEAUTAUD - groupe intra) 9 - ELECTRABEL: post-Fukushima improvements from the radiological approach to the emergency plan (Benoit LANCE, Electrabel); 10 - EDF: innovation at the service of intervenors in crisis situation (Emmanuelle GAILLARD-LECANU, EDF); 11 - CEA: new crisis management tools and the related radiation protection sensors (Karim BOUDERGUI, CEA); 12 - AREVA: R and D at the service of interventions in crisis situation (Jean-Reynald MACE); 13 - ISOE works (Olivier COUASNON, ASN)

  16. Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia

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    Salade L

    2017-11-01

    Full Text Available Laurent Salade,1 Nathalie Wauthoz,1 Magali Deleu,2 Marjorie Vermeersch,3 Carine De Vriese,1 Karim Amighi,1 Jonathan Goole1 1Laboratoire de Pharmacie Galénique et de Biopharmacie, Université libre de Bruxelles (ULB, Brussels, 2Laboratoire de Biophysique Moléculaire aux Interfaces, Gembloux Agro-Bio Tech, Université de Liège, Gembloux, 3Centre for Microscopy and Molecular Imaging (CMMI, Charleroi, Belgium Abstract: The aim of the present study was to develop a ghrelin-containing formulation based on liposomes coated with chitosan intended for nose–brain delivery for the treatment of cachexia. Among the three types of liposomes developed, anionic liposomes provided the best results in terms of encapsulation efficiency (56% and enzymatic protection against trypsin (20.6% vs 0% for ghrelin alone and carboxylesterase (81.6% vs 17.2% for ghrelin alone. Ghrelin presented both electrostatic and hydrophobic interactions with the anionic lipid bilayer, as demonstrated by isothermal titration calorimetry. Then, anionic liposomes were coated with N-(2-hydroxypropyl-3-trimethyl ammonium chitosan chloride. The coating involved a size increment from 146.9±2.7 to 194±6.1 nm, for uncoated and coated liposomes, respectively. The ζ-potential was similarly increased from -0.3±1.2 mV to 6±0.4 mV before and after coating, respectively. Chitosan provided mucoadhesion, with an increase in mucin adsorption of 22.9%. Enhancement of permeation through the Calu3 epithelial monolayer was also observed with 10.8% of ghrelin recovered in the basal compartment in comparison to 0% for ghrelin alone. Finally, aerosols generated from two nasal devices (VP3 and SP270 intended for aqueous dispersion were characterized with either coated or uncoated liposomes. Contrarily to the SP270 device, VP3 device showed minor changes between coated and uncoated liposome aerosols, as shown by their median volume diameters of 38.4±5.76 and 37.6±5.74 µm, respectively. Overall, the

  17. Confocal microscopy findings in deep anterior lamellar keratoplasty performed after Descemet's stripping automated endothelial keratoplasty

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    Pang A

    2014-01-01

    Full Text Available Audrey Pang,1,2 Karim Mohamed-Noriega,1 Anita S Chan,1,3–5 Jodbhir S Mehta1,3 1Singapore National Eye Centre, 2Department of Ophthalmology, Tan Tock Seng Hospital, 3Singapore Eye Research Institute, 4Department of Histopathology, Pathology, Singapore General Hospital, 5Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Background: This study describes the in vivo confocal microscopy findings in two patients who had deep anterior lamellar keratoplasty (DALK following Descemet's stripping automated endothelial keratoplasty (DSAEK. Methods: The study reviewed the cases of two patients who first underwent DSAEK followed by DALK when their vision failed to improve due to residual stromal scarring. In the first case, a DSAEK was performed for a patient with pseudophakic bullous keratopathy. After surgery, the patient's vision failed to improve satisfactorily due to residual anterior stromal opacity and irregularity. Subsequently, the patient underwent a DALK. The same two consecutive operations were performed for a second patient with keratoconus whose previous penetrating keratoplasty had failed and had secondary graft ectasia. In vivo confocal microscopy was performed 2 months after the DALK surgery in both cases. Results: At 3 months after DALK, the best-corrected visual acuity was 6/30 in case 1 and 6/24 in case 2. In vivo confocal microscopy in both cases revealed the presence of quiescent keratocytes in the stroma layers of the DSAEK and DALK grafts, which was similar in the central and peripheral cornea. There was no activated keratocytes or haze noted in the interface between the grafts. Conclusion: Our short-term results show that performing a DALK after a DSAEK is an effective way of restoring cornea clarity in patients with residual anterior stromal opacity. In vivo confocal microscopy showed that there were no activated keratocytes seen in the interface of the grafts, which suggests

  18. Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data

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    Biset N

    2018-01-01

    Full Text Available Natacha Biset,1,* Mélanie Lelubre,1–3,* Christelle Senterre,4 Karim Amighi,1 Olivier Bugnon,2,3 Marie P Schneider,2,3 Carine De Vriese1 1Department of Pharmacotherapy and Pharmaceutics, Faculté de Pharmacie, Université libre de Bruxelles (ULB, Brussels, Belgium; 2School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland; 3Community Pharmacy, Department of Ambulatory Care & Community Medicine, University of Lausanne, Lausanne, Switzerland; 4Research Center of Epidemiology, Biostatistics and Clinical Research, School of Public Health, Université libre de Bruxelles (ULB, Brussels, Belgium *These authors contributed equally to this work Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings and to evaluate the concomitant use of contraception and isotretinoin. Methods: Reimbursed prescription data from January 2012 to August 2015 of all patients in Belgium were received from Pharmanet–National Institute for Health and Disability Insurance. Medication adherence was measured according to the medication possession ratio. The influence of gender and age was analyzed using the Mann–Whitney test and the Spearman coefficient correlation. The independence between adherence to contraception and adherence to isotretinoin was analyzed using the Pearson chi-square test of independence. Persistence was defined as the number of days between initiation and presumed end of treatment. The Kaplan–Meier method was used to plot the medication persistence curves, and the log-rank test was used to compare the curves. The concomitant use of contraception and isotretinoin was analyzed using descriptive statistics. Results: The medication possession ratio was ≥0.8 for 46.1% of patients receiving isotretinoin and for 74.0% of women using contraception. For isotretinoin, this percentage decreased as the number of

  19. SHORT STORIES IN THE BALKANS AND CONTEMPORARYSHORT STORIES IN THE WORLD

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    Larisa Softic - Gasal

    2014-01-01

    Full Text Available A comparative analysis of selected short stories in the Balkan countries, as well as contemporary short stories of the world, will show us that the key themes of those stories are very similar to the short stories written during the period of transition in Bosnia and Herzegovina (1995-2010. For example, the story of the Soul Operation by an Iranian writer Mohsen Mahmalbafa, The Falcons by a Dutch writer Kader Abdolaha and On the Kitchen Stairs by a Polish writer Witold Gombrowic zinter connect with short stories by authors from Bosnia and Herzegovina, such as The Secret of Raspberry jam by Karim Zaimović or The Devilish work of Zoran Riđanović. A common thread manifests itself in the aforementioned stories, more specifically, a common theme which focuses on the need for eradication of the seeds of submission and compliance with the political system. Most authors focus on their domestic political systems; however, some portray and analyze systems in other countries as they see it, such as a Dutch narrator who focuses on a potential threat of infringement of human freedom. Moreover, Bellow Hubei by an Argentinian writer Anhelika Gorodis her underlines the importance of humanization within a political order. Faruk Šehić examines the political system in Bosnia and Herzegovina from a slightly different perspective. His collection of stories Under Pressure emphases the issue of pressure in the above war model of short stories in Bosnia and Herzegovina. These stories are the product of pressure and anxiety, with intent to latently promote new ways of spiritual survival, directly relating to the concept and the theme of the story The Past Age Man by Christian Karlson Stead. Further analysis of the alienation theme singled out short stories in Bosnia and Herzegovina, Plants are Something Else by Alma Lazarevska and Dialogues by Lamija Begagić, and pointed out their connection with some recent international short stories such as The Last Defence by

  20. Carbon Nanotubes Technology for Removal of Arsenic from Water

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    Ali Naghizadeh

    2012-08-01

    Full Text Available Please cite this article as: Naghizadeh A, Yari AR, Tashauoei HR, Mahdavi M, Derakhshani E, Rahimi R, Bahmani P. Carbon nanotubes technology for removal of arsenic from water. Arch Hyg Sci 2012;1(1:6-11. Aims of the Study: This study was aimed to investigate the adsorption mechanism of the arsenic removal from water by using carbon nanotubes in continuous adsorption column. Materials & Methods: Independent variables including carbon nanotubes dosage, contact time and breakthrough point were carried out to determine the influence of these parameters on the adsorption capacity of the arsenic from water. Results: Adsorption capacities of single wall and multiwall carbon nanotubes were about 148 mg/g and 95 mg/g respectively. The experimental data were analyzed using Langmuir and Freundlich isotherm models and equilibrium data indicate the best fit obtained with Langmuir isotherm model. Conclusions: Carbon nanotubes can be considered as a promising adsorbent for the removal of arsenic from large volume of aqueous solutions. References: 1. Lomaquahu ES, Smith AH. Feasibility of new epidemiology studies on arsenic exposures at low levels. AWWA Inorganic Contaminants Workshop. San Antonio; 1998. 2. Burkel RS, Stoll RC. Naturally occurring arsenic in sandstone aquifer water supply wells of North Eastern Wisconsin. Ground Water Monit Remediat 1999;19(2:114-21. 3. Mondal P, Majumder CB, Mohanty B. Laboratory based approaches for arsenic remediation from contaminated water: recent developments. J Hazard Mater 2006;137(1: 464-79. 4. Meenakshi RCM. Arsenic removal from water: a review. Asian J Water Environ Pollut 2006;3(1:133-9. 5. Wickramasinghe SR, Binbing H, Zimbron J, Shen Z, Karim MN. Arsenic removal by coagulation and filtration: comparison of ground waters from United States and Bangladesh. Desalination 2004;169:231-44. 6. Hossain MF. Arsenic contamination in Bangladesh-an overview. Agric Ecosyst Environ 2006;113(1-4:1-16. 7. USEPA, Arsenic. Final

  1. The SAWO (Small And Well Organized) avatar teaches the importance of the aggregates on the soil system and how to determine their stability

    Science.gov (United States)

    Mataix-Solera, Jorge; Cerdà, Artemi; Jordán, Antonio; Úbeda, Xavier; Pereira, Paulo

    2015-04-01

    Spanish Government for finance the POSTFIRE project (CGL2013- 47862-C2-1-R). The research projects GL2008-02879/BTE, LEDDRA 243857 and PREVENTING AND REMEDIATING DEGRADATION OF SOILS IN EUROPE THROUGH LAND CARE (RECARE)FP7-ENV-2013- supported this research. References Cerdà, A. 1996. Soil aggregate stability in three mediterranean environments. Soil Technology, 9, 129-133. Cerdà, A. 1998. Soil aggregate stability under different Mediterranean vegetation types. Catena, 32, 73-86. Cerdà, A. 2000. Aggregate stability against water forces under different climates on agriculture land and scrubland in southern Bolivia. Soil and Tillage Research, 36, 1- 8. Cerdà, A., Mataix-Solera, J., Arcenegui, V. (2012, April). Aggregate stability in citrus plantations. The impact of drip irrigation. In EGU General Assembly Conference Abstracts (Vol. 14, p. 3772). García-Orenes, F., Roldán, A., Mataix-Solera, J., Cerdà, A., Campoy, M., Arcenegui, V., Caravaca, F. 2012. Soil structural stability and erosion rates influenced by agricultural management practices in a semi-arid Mediterranean agro-ecosystem. Soil Use and Management 28(4): 571-579. DOI: 10.1111/j.1475-2743.2012.00451.x Gelaw, A. M., Singh, B. R., Lal, R. 2015. Organic carbon and nitrogen associated with soil aggregates and particle sizes under different land uses in Tigray, northern Ethiopia. Land Degradation & Development.DOI: 10.1002/ldr.2261 Hallett, P., Ogden, M., Karim, K., Schmidt, S., Yoshida, S. (2014, May). Beneath aggregate stability-quantifying thermodynamic properties that drive soil structure dynamics. In EGU General Assembly Conference Abstracts (Vol. 16, p. 10792). Jordán, A., Zavala, L. M., Mataix-Solera, J., Nava, A. L., Alanís, N. (2011). Effect of fire severity on water repellency and aggregate stability on Mexican volcanic soils. Catena, 84(3), 136-147. Jordan, M., Garcia-Orenes, F., Mataix-Solera, J., Garcia-Sanchez, E. (2012, April). Evaluation of the physical properties, bulk density and aggregate

  2. Editorial

    Directory of Open Access Journals (Sweden)

    AHM Zahirul Alam

    2018-06-01

    notes, and Letters to the editor (no page charge. Book reviews, reports of and/or call for papers of conferences, symposia and meetings, and advances in research equipment could also be published in IIUM Engineering Journal with minimum charges. REFEREES’ NETWORK All papers submitted to IIUM Engineering Journal will be subjected to a rigorous reviewing process through a worldwide network of specialized and competent referees. Each accepted paper should have at least two positive referees’ assessments. SUBMISSION OF A MANUSCRIPT A manuscript should be submitted online to the IIUM-Engineering Journal website: http://journals.iium.edu.my/ejournal. Further correspondence on the status of the paper could be done through the journal website and the e-mail addresses of the Executive Editor: zahirulalam@iium.edu.my Faculty of Engineering, International Islamic University Malaysia (IIUM, Jan Gombak, 53100, Kuala Lumpur, Malaysia. Phone: (603 6196 4529, Fax:(603 6196 4488.          INTERNATIONAL ADVISORY COMMITTEE   A. Anwar, United States Abdul Latif Bin Ahmad, Malaysia Farzad Ismail, USM, Pulau Pinang, Malaysia Hanafy Omar, Saudi Arabia Hany Ammar, United States Idris Mohammed Bugaje, Nigeria K.B. Ramachandran, India Kunzu Abdella, Canada Luis Le Moyne, ISAT, University of Burgundy, France M Mujtaba, United Kingdom Mohamed AI-Rubei, Ireland Mohamed B Trabia, United States Mohammad S. Alam, Texas A&M University-Kingsville, United States Nazmul Karim Ossama Abdulkhalik, Michigan Technological University, United States Razi Nalim, IUPUI, Indianapolis, Indiana, United States Syed Kamrul Islam, United States Tibor Czigany, Budapest University of Technology and Economics, Hungary Yiu-Wing Mai, The University of Sydney, Australia.               Published by: IIUM Press, International Islamic University Malaysia Jalan Gombak, 53100 Kuala Lumpur, Malaysia Phone (+603 6196-5014, Fax: (+603 6196-6298 Website: http://iiumpress.iium.edu.my/bookshop     Whilst every effort

  3. Innovations in the Poetry Form by Sheikh Sa'd od-Din Ahmad Ansari

    Directory of Open Access Journals (Sweden)

    Najaf Jowkar

    2016-05-01

    Full Text Available AbstractSheikh Sa'd od-Din Ahmad َ Ansari, the son of Mawlana Abd ol-Ghaffar Ibn Abd ol-Karim, is a mystic of the 12th and 13th centuries AH. Sa'd od-Din was born in Kabul in the village called Yahya Yahyaee in 1140 AH and died in the same place in 1225 AH (Ansari, 1374: 6. In his youth, he learned canonical law and theology from his father but was soon attracted to mysticism (Heravi, 1373, 43. After performing Hajj in between the years 1169-113 AH and getting permission to guide people from Naqshbandiyeh and Qaderiyeh mystic Sheikh Mohammad Saman Madani, he returned home and guided people untill the end of his life (Ansari, 1390: 3. Sheikh Sa'd od-Din was well learned in Islamic studies, Arabic language, rhetoric and sciences of his time. He was also familiar with the works of poets such as 'Attar, Rumi, Hafez, Ibn Arabi and other great names of mysticism. He was attached to Rumi and Hafez and has quoted them frequently in his works.Sheikh Sa'd od-Din wrote thirty six books and treatises including seven Divans and two Masnavis in Persian; He also wrote a book entitled The Mine of Unity and treatises  such as "Greetings Noble Tatar", "Habl ol-Matin" and "The Elite" in Arabic. He composed some poems in Arabic as well.At least from 1174 AH Sheikh Sa'd od-Din started to bring changes to the ancient Persian poetry; thus his deconstruction made poetical form much similar to contemporary Persian poetry. However, due to political and cultural distance between Iran and Afghanistan, we did not have a chance to get familiar with his innovations.His innovations consist of the following:1.      Refrained Masnavi (masnavi tarjee'band: He changed masnavi in a way that we can call it refrained masnavi, a sample of which is included in the paper. It consists of fifteen stanzas: The first stanza with eight lines, the second stanza fifty four lines, the twelfth stanza eleven lines and the other stanzas having equal lines. The line between

  4. The Emphasizing Metonymy and Its Relation Whit Ambiguity of Text

    Directory of Open Access Journals (Sweden)

    Amir Saleh Masoomi

    2016-05-01

    .   12. ------------------------------------------ (1998. Al-Izah fi Olum al-Balaghah. Beirut: House of Revival of science.   13. Matouq, Hussein (2005. Al-Insaf fi Masael al-Khilaf. Kuwait: library of Irfan.   14. Qutaiba son, Abdullah ibn Muslim, (2007. Ta'wil Mushkel al-Quran. Ibrahim Shams al-Din (Emend.. Beirut: House of scientific books.   15. Sabban, Mohammed ibn Ali (1997. Hashyat al-Sabban ala Sharh al-Oshmuni. Beirut: house of scientific books.   16. Sakkaki, Yusuf bin Mohammed (2000. Meftah al-Olum. Abdul Hamid Hindawi (Emend.. Beirut: House of scientific books.   17. Shahristani, Muhammad ibn Abd al-Karim (1983. Al-Milal va al-Nihal. Seyed Mohammed Kilani (Emend.. Beirut: House of knowledge.   18. Suyooti, Abdulrahman ibn Ibepkr (n.d.. Hama’ al-Hawame' fi Sharh Jam'e al-jame. Abdul Hameed Hindawi (Emend.. Egypt: Tafiqiah Library.   19. Taftazani, Masoud ibn Omar (2005. Al-Motawal, Sharh Talkhis al-Miftah. Ahmad Azv Enayah (Emend.. Beirut: House of Revival of Islamic Heritage.   20. Zahabi, Mohammed ibn Ahmad (1985. Siar A'alam al-Nubala. A group of investigators under the supervision of Shoaib Arnaout. Beirut: Al-Resalah Institute.   21. --------------------------------------- (2000. Al-Bahr al-Muhit fi Osul al-Fiqh. Mohamed Mohamed Tamer (Emend.. Beirut: House of scientific books.   Zrkashi, Mohammed ibn Bahadur (1957. Al-Borhan fi Olum al-Quaran. Abolfazl Mohammad Ibrahim (Emend.. Cairo: House of revival of Arabic books.

  5. FOREWORD: Computational methodologies for designing materials Computational methodologies for designing materials

    Science.gov (United States)

    Rahman, Talat S.

    2009-02-01

    084206 [7] Biswas P, Tafen D N, Inam F, Cai B and Drabold D A 2009 Materials modeling by design: applications to amorphous solids J. Phys.: Condens. Matter 21 084207 [8] Rossi G and Ferrando R 2009 Searching for low-energy structures of nanoparticles: a comparison of different methods and algorithms J. Phys.: Condens. Matter 21 084208 [9] Rogan J, Ramírez M, Muñoz V, Alejandro Valdivia J, García G, Ramírez R and Kiwi M 2009 Diversity driven unbiased search of minimum energy cluster configurations J. Phys.: Condens. Matter 21 084209 [10] Pedersen A, Pizzagalli L and Jónsson H 2009 Finding mechanism of transitions in complex systems: formation and migration of dislocation kinks in a silicon crystal J. Phys.: Condens. Matter 21 084210 [11] Trushin O, Jalkanen J, Granato E, Ying S C and Ala-Nissila T 2009 Atomistic studies of strain relaxation in heteroepitaxial systems J. Phys.: Condens. Matter 21 084211 [12] Fichthorn K A, Miron R A, Wang Y and Tiwary Y 2009 Accelerated molecular dynamics of thin-film growth with the bond-boost method J. Phys.: Condens. Matter 21 084212 [13] Kara A, Trushin O, Yildirim H and Rahman T S 2009 Off-lattice self-learning kinetic Monte Carlo: application to 2D cluster diffusion on the fcc(111) surface J. Phys.: Condens. Matter 21 084213 [14] Nandipati G, Shim Y, Amar J G, Karim A, Kara A, Rahman T S and Trushin O 2009 Parallel kinetic Monte Carlo simulations of Ag(111) island coarsening using a large database J. Phys.: Condens. Matter 21 084214 [15] Hamouda A, Stasevich T J, Pimpinelli A and Einstein T L 2009 Effects of impurities on surface morphology: some examples J. Phys.: Condens. Matter 21 084215 [16] Li M, Han Y, Thiel P A and Evans J W 2009 Formation of complex wedding-cake morphologies during homoepitaxial film growth of Ag on Ag(111): atomistic, step-dynamics, and continuum modeling J. Phys.: Condens. Matter 21 084216 [17] Uhlík F, Gatti R and Montalenti F 2009 A fast computational method for determining equilibrium concentration