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Sample records for kari hansen wagner

  1. Alfred Hansen

    DEFF Research Database (Denmark)

    Friis, Ib; Wind, Peter; Pedersen, Henrik Ærenlund

    2008-01-01

    Nekrolog over botanikeren Alfred Hansen, leder af Dansk Herbarium på Botanisk Museum, Københavns Universitet, med gennemgang af hans videnskabelige og formidlende publikationer og indsats som samler af videnskabeligt materiale.......Nekrolog over botanikeren Alfred Hansen, leder af Dansk Herbarium på Botanisk Museum, Københavns Universitet, med gennemgang af hans videnskabelige og formidlende publikationer og indsats som samler af videnskabeligt materiale....

  2. Penanggulangan Karies Rampan Serta Keluhannya Pada Anak

    Directory of Open Access Journals (Sweden)

    Heriandi Sutadi

    2015-09-01

    Full Text Available Karies rampan merupakan masalah yang sering ditemukan pada anak usia balita. Adanya karies rampan dapat menyebabkan berbagai masalah, terutama yang berhubungan dengan kesehatan umum anak yang sedang dalam masa pertumbuhan. Pada anak dengan karies rampan sering kali ditemukan keluhan seperti : anak sulit makan karena adanya rasa sakit bila mengunyah, makan sering diemut, bahkan lebih lanjut sering terjadi pembengkakan atau abses. Berbagai penyebab faktor terjadinya karies rampan, akan tetapi yang utama adalah kurangnya kebersihan mulut, struktur gigi yang kurang baik, seringnya makan makanan yang mengandung gula, serta adanya aktifitas bakteri seperti karies yang tinggi. Karies rampan harus segera ditanggulangi terutama untuk menghentikan keluhan yang dirasakan, menghilangkan faktor penyebab utama, menanggulangi akibat adanya patologis pada gigi dan jaringan mulut lainnya. Selanjutnya melakukan pencegahan secara berkesinambungan agar kesehatan gigi dan mulut dapat terjaga dengan baik.

  3. Peranan Matriks Metaloproteinases Pada Lesi Karies Dentin

    OpenAIRE

    Baru Fajriani, Baru Fajriani

    2016-01-01

    Karies gigi merupakan suatu demineralisasi yang terlokalisasi pada permukaan gigi yang disebabkan oleh metabolisme asam organik dari mikroorganisme dalam mulut. Proses karies dan faktor risiko terjadinya pada gigi tetap dan sulung tidak berbeda, namun proses karies gigi sulung lebih cepat menyebar, meluas dan lebih parah dibandingkan gigi permanen. Kerusakan gigi menunjukkan corak tertentu yang memperlihatkan urutan permukaan dan jenis gigi sulung serta tingkat keparahannya pada setiap gigi. ...

  4. Leprosy (Hansen's Disease)

    Science.gov (United States)

    ... with facebook share with twitter share with linkedin Leprosy (Hansen's Disease) Leprosy (Hansen's Disease) is a chronic ... as Mycobacterium leprae . Why Is the Study of Leprosy (Hansen's Disease) a Priority for NIAID? At the ...

  5. On Paradoxurus annulatus, Wagner

    NARCIS (Netherlands)

    Jentink, F.A.

    1886-01-01

    In »die Säugethiere Schreber’s, Supplementband II” we find on p. 353 the following description of a new Paradoxurus by J. E. Wagner: P. annulatus Wagn. Der geringelte Roller. P. supra. e nigro fulvoque mixtus, subtus e ferrugineo lutescens, cauda nigro-annulata, auriculis dense pilosis.

  6. Penghentian Karies Gigi Sulung Anterior (Laporan Penelitian

    Directory of Open Access Journals (Sweden)

    Titi Pratiwi Indra Yoga

    2015-10-01

    Full Text Available Salah satu cara menanggulangi karies pada gigi sulung anterior adalah dengan mengasah gigi menjadi bentuk self cleansing atau tapered dan kemudian mengolesnya dengan larutan SnF2 10%. Cara ini relatif mudah mengerjakannya serta murah biayanya. Keburukannya hanya pada masalah estetis, yaitu bentuk gigi menjadi lebih kecil, serta adanya staining kecoklatan karena pengendapan Sn. Penelitian ini dilakukan untuk mengetahui apakah cara ini dapat menghentikan karies pada gigi sulung anterior, serta sampai berapa lama pengaruh SnF2 10% dapat menghentikan karies. Sampel diambil dari murid TK yang berusia 2,5 sampai 5 tahun, gigi sulung anteriornya terkena karies email pada bagian proksimal satu atau dua sisi. Mengingat usia sampel yang masih muda, maka sampai akhir penelitian hanya didapat 20 orang anak yang memenuhi kriteria, dan hasil penelitian dihitung secara statistik dengan X2 – test. Hasil penelitian ternyata prosedur perawatan ini berhasil secara bermakna setelah 3-6 bulan (X2 = 0.056, df = 1, dan p < 0.05.

  7. Reply to Hansen

    Science.gov (United States)

    Leibert, Todd W.

    2012-01-01

    Hansen (2012a) and the author are both concerned about trends in the counseling culture toward oversimplification. Their disagreement is, principally, about the locus of debate. The author responds to Hansen's counterarguments with the ultimate hope of transferring the focus from scientific ideology to economic realities pervading professional…

  8. IDENTIFIKASI BAKTERI PADA KARIES GIGI PENDERITA DIABETES MELITUS

    OpenAIRE

    GUFRANI, NURUL

    2014-01-01

    2014 Diabetes melitus adalah penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Ada tiga keluhan khas dari penderita diabetes melitus yaitu poliuria, polidipsia, dan polifagia. Kasus diabetes melitus terus meningkat seiring berkembangnya zaman. Salah satu manifestasi oral yang ditemukan pada penderita diabetes melitus adalah karies gigi. Karies gigi merupakan penyakit yang mempunyai etiologi multifaktoral, ak...

  9. Lahkus Mihkel Hansen

    Index Scriptorium Estoniae

    2004-01-01

    20. nov. 2004 Torontos surnud advokaadi, poliitiku ja aktiivse rahvusliku tegelase nekroloog. M. Hansen oli nii Eesti Liidu Kanadas, Toronto Eesti Seltsi kui ka Eesti Abistamiskomitee Kanadas asutajaks ning esimeseks esimeheks

  10. Implementing Hansen's Proficiencies.

    Science.gov (United States)

    Carlson, J. Lon; Cohn, Raymond L.; Ramsey, David D.

    2002-01-01

    Describes an economics department framework that incorporates the William Lee Hansen curriculum proficiencies. Identifies tools students should be able to use to complete specific activities, significant prerequisite changes for upper division courses, and the development of a capstone project to employ student skills and knowledge. (JEH)

  11. Rejoinder to Hansen

    Science.gov (United States)

    Suthakaran, V.

    2012-01-01

    Hansen (2012b) reiterates his view that the humanities should form the ideological foundation of the counseling profession by challenging the validity of the central premises for the author's argument that the humanities and science should have equal ideological standing. The author attempts to explain the reasons for their conflicting ideas on…

  12. Poul Hansen Egede

    DEFF Research Database (Denmark)

    Andersen, Jan

    Grønlandsforskeren Poul Hansen Egede er med sin eksemplariske indsamling, bearbejdning og formidling af viden om grønlandsk kultur og sprog en central skikkelse i Grønlands tidlige videnskabshistorie. Skildringen af Poul Egedes liv og værk bygger på hans egne optegnelser samt på hidtil upåagtede...

  13. Statskonsulent K. Hansen

    DEFF Research Database (Denmark)

    Kristensen, Birgit Juul

    2011-01-01

    Beskrivelse af gammel bogsamling fra Ladelund Landbrugsskole (nu Syddansk Universitetsbibliotek i Esbjerg), samlet af Statskonsulent K. Hansen (1858-1941). Derudover en fremstilling af hans liv og virke som statskonsulent i planteavl for Øerne, leder af Dansk Landbrugsmuseum, forfatter af...

  14. Karo-kari: a form of honour killing in pakistan.

    Science.gov (United States)

    Patel, Sujay; Gadit, Amin Muhammad

    2008-12-01

    Karo-Kari is a type of premeditated honour killing, which originated in rural and tribal areas of Sindh, Pakistan. The homicidal acts are primarily committed against women who are thought to have brought dishonour to their family by engaging in illicit pre-marital or extra-marital relations. In order to restore this honour, a male family member must kill the female in question. We conducted a systematic review of the published literature other sources on karo-kari and related forms of honour killing or violence against women. Media and non-governmental organization reports were utilized for case studies and analysis. Although legally proscribed, socio-cultural factors and gender role expectations have given legitimacy to karo-kari within some tribal communities. In addition to its persistence in areas of Pakistan, there is evidence that karo-kari may be increasing in incidence in other parts of the world in association with migration. Moreover, perpetrators of ;honour killings' often have motives outside of female adultery. Analysis of the socio-cultural and psycho-pathological factors associated with the practice of karo-kari can guide the development of prevention strategies.

  15. [Diagnosis of Hansen's disease].

    Science.gov (United States)

    Yotsu, Rie Roselyne; Suzuki, Koichi; Mori, Shuichi; Ishii, Norihisa

    2011-02-01

    The Leprosy Mailing List (LML) is an e-mailing list open to whoever interested in the field from all over the world. It acts as a forum for exchanging information related to Hansen's disease. It was established in February 2001 in Italy, and the present moderator of the LML is Dr. Salvatore Noto. He and his colleague have recently introduced an atlas for diagnosing Hansen's disease which they brought together information and photos collected through the LML. The atlas is divided into three sections, (1) Introduction, (2) Cardinal signs, and (3) Diagnosis and the clinical spectrum of leprosy, and they are all accompanied with relevant photos. This time, Dr. Noto kindly permitted us to translate the atlas into Japanese to be published in the Japanese Journal of Leprosy and posted in the Japanese Leprosy Association homepage. This article includes the translation and some of the most informative photos. For more information, please refer to the homepage where you will find all photos in the atlas.

  16. [Kari Tarkiainen, Ülle Tarkiainen. Provinsen bortom havet : Estlands svenska historia 1561-1710; Kari Tarkiainen, Ülle Tarkiainen. Meretagune maa : Rootsi aeg Eestis 1561-1710] / Pärtel Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Pärtel, 1972-

    2015-01-01

    Arvustus: Tarkiainen Kari, Tarkiainen Ülle. Provinsen bortom havet : Estlands svenska historia 1561-1710 Verlag Atlantis. Stockholm 2013; Tarkiainen, Kari, Tarkiainen, Ülle. Meretagune maa : Rootsi aeg Eestis 1561-1710. verlag Varrak Tallinn 2014

  17. [Kari Tarkiainen, Ülle Tarkiainen. Provinsen bortom havet : Estlands svenska historia 1561-1710; Kari Tarkiainen, Ülle Tarkiainen. Meretagune maa : Rootsi aeg Eestis 1561-1710] / Pärtel Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Pärtel, 1972-

    2015-01-01

    Arvustus: Tarkiainen Kari, Tarkiainen Ülle. Provinsen bortom havet : Estlands svenska historia 1561-1710 Verlag Atlantis. Stockholm 2013; Tarkiainen, Kari, Tarkiainen, Ülle. Meretagune maa : Rootsi aeg Eestis 1561-1710. verlag Varrak Tallinn 2014

  18. Hansen's disease: a vanishing disease?

    Directory of Open Access Journals (Sweden)

    Sinésio Talhari

    2012-12-01

    Full Text Available The introduction, implementation, successes and failures of multidrug therapy (MDT in all Hansen's disease endemic countries are discussed in this paper. The high efficacy of leprosy treatment with MDT and the global reduction of prevalence led the World Health Organization, in 1991, to establish the goal of elimination of Hansen's disease (less than 1 patient per 10,000 inhabitants to be accomplished by the year 2000. Brazil, Nepal and East Timor are among the few countries that didn't reach the elimination goal by the year 2000 or even 2005. The implications of these aspects are highlighted in this paper. Current data from endemic and previously endemic countries that carry a regular leprosy control programme show that the important fall in prevalence was not followed by the reduction of the incidence. This means that transmission of Mycobacterium leprae is still an issue. It is reasonable to conclude that we are still far from the most important goal of Hansen's disease control: the interruption of transmission and reduction of incidence. It is necessary to emphasize to health managers the need of keeping Hansen's disease control activities to better develop control programmes in the future. The recent international proposal to interrupt the transmission of leprosy by the year 2020 seems to unrealistic and it is discussed in this paper. The possibility of epidemiological impact related to the human immunodeficiency virus/Hansen's disease coinfection is also considered.

  19. Hansen's disease: a vanishing disease?

    Science.gov (United States)

    Talhari, Sinésio; Grossi, Maria Aparecida de Faria; Oliveira, Maria Leide W D R de; Gontijo, Bernardo; Talhari, Carolina; Penna, Gerson Oliveira

    2012-12-01

    The introduction, implementation, successes and failures of multidrug therapy (MDT) in all Hansen's disease endemic countries are discussed in this paper. The high efficacy of leprosy treatment with MDT and the global reduction of prevalence led the World Health Organization, in 1991, to establish the goal of elimination of Hansen's disease (less than 1 patient per 10,000 inhabitants) to be accomplished by the year 2000. Brazil, Nepal and East Timor are among the few countries that didn't reach the elimination goal by the year 2000 or even 2005. The implications of these aspects are highlighted in this paper. Current data from endemic and previously endemic countries that carry a regular leprosy control programme show that the important fall in prevalence was not followed by the reduction of the incidence. This means that transmission of Mycobacterium leprae is still an issue. It is reasonable to conclude that we are still far from the most important goal of Hansen's disease control: the interruption of transmission and reduction of incidence. It is necessary to emphasize to health managers the need of keeping Hansen's disease control activities to better develop control programmes in the future. The recent international proposal to interrupt the transmission of leprosy by the year 2020 seems to unrealistic and it is discussed in this paper. The possibility of epidemiological impact related to the human immunodeficiency virus/Hansen's disease coinfection is also considered.

  20. [HANSEN'S DISEASE IN ISRAEL].

    Science.gov (United States)

    Gilead, Leon; Wexler, Ruth

    2016-10-01

    Hansen's disease (HD) is an anthropophylic, infectious, chronic disease, caused by Mycobacterium leprae. The systemic disease, affecting both males and females at any age, involves mainly the skin and the peripheral nerves located in the limbs close to the skin. Traditionally the treatment of HD patients was entrusted to dermatologists. Current drug therapy given at an early stage can prevent many of the complications, and enables patients to go on with life. In 95% of the population there is an innate immunity, which following exposure, enables the development of an effective immune response preventing the development of overt clinical disease. So far, there is neither an effective vaccination nor a simple test which can predict susceptibility to the infection. A long history of ignorance and stigmatization may add a social dimension to the physical ailment and suffering of HD patients. Despite the elimination campaign declared by the WHO in the early 1990s, the disease continues to exist. New patients are diagnosed each year, though in lower numbers and HD patients can be found all over the world. The relatively low prevalence of HD in non-endemic countries and the misconception that it has been eradicated long ago, make the awareness to the disease extremely poor. HD is usually not included in the differential diagnosis even when clear symptoms are present. This results in a very late diagnosis of new HD patients, thus missing the window of opportunity for early treatment which could prevent complications and disability. The purpose of this update is to raise awareness to the existence of HD in Israel and its diagnosis, to present updated epidemiological data for Israel and a glimpse at the global situation.

  1. Darwin and Wagner: Evolution and Aesthetic Appreciation

    Science.gov (United States)

    Ostergaard, Edvin

    2011-01-01

    Two of the most influential works of the Western nineteenth century were completed in 1859: Charles Darwin's "The Origin of Species" and Richard Wagner's opera "Tristan and Isolde." Although created within very different cultural traditions, these works show some striking similarities: both brought about a critical, long-lasting debate and caused…

  2. Darwin and Wagner: Evolution and Aesthetic Appreciation

    Science.gov (United States)

    Ostergaard, Edvin

    2011-01-01

    Two of the most influential works of the Western nineteenth century were completed in 1859: Charles Darwin's "The Origin of Species" and Richard Wagner's opera "Tristan and Isolde." Although created within very different cultural traditions, these works show some striking similarities: both brought about a critical, long-lasting debate and caused…

  3. K-MEANS UNTUK KLASIFIKASI PENYAKIT KARIES GIGI

    Directory of Open Access Journals (Sweden)

    Novita Meisida

    2016-04-01

    Full Text Available Oral health problems , a concern which is very important in health development. Results of Household Health Survey report in 2001 showed that oral health in Indonesia are things that need attention. Based on the report of Poly Teeth ITS Medical Center 2009 obtained data characteristics of dental caries and dental caries classes based on the anatomy of the JV Black. From these data can be classification using K - Means clustering method. K -Means clustering method is used for grouping data partitioning system, where data in one group have similar characteristics to each other, and have different characteristics with other groups. Classification results using K - Means Clustering method will be compared with the results of reports Poly Teeth ITS Medical Center 2009, to compare and get result from accuracy of the K - Means Clustering. Keywords: K-Means, Caries, Classification Masalah kesehatan gigi dan mulut, menjadi perhatian yang sangat penting dalam pembangunan kesehatan. Hasil laporan survei Kesehatan Rumah Tangga tahun 2001 menunjukkan bahwa kesehatan gigi dan mulut di Indonesia merupakan hal yang perlu diperhatikan. Berdasarkan hasil laporan Poli Gigi Medical Center ITS 2009 didapatkan data-data berupa data karakteristik karies gigi dan kelas-kelas karies gigi berdasarkan anatomi J. V. Black. Dari data-data tersebut dapat dilakukan pengklasifikasian dengan menggunakan metode Clustering K-Means. Metode Clustering K-Means digunakan karena K-Means melakukan pengelompokkan data dengan sistem partisi, dimana data dalam satu kelompok memiliki karakteristik yang sama satu sama lainnya, dan memiliki karekteristik berbeda dengan kelompok lainnya. Hasil pengklasifikasian metode ClusteringK-Means dibandingkan hasilnya dengan laporan Poli Gigi Medical Center ITS 2009, untuk membandingkan keakuratanClustering K-Means. Kata Kunci: K-Means, Karies Gigi, Klasifikasi

  4. The articulation of impressions An interview with Kari Martinsen

    Directory of Open Access Journals (Sweden)

    Christine Øye

    2016-05-01

    Full Text Available About Kari Martinsen Kari Martinsen is a psychiatric nurse and has a masters degree in philosophy and a PhD in history. She is currently Professor Emerita at the University of Tromsø and VID Specialized University, Bergen Campus. Martinsen has worked at the University of Bergen and University of Tromsø in Norway, and Aarhus University in Denmark. At Aarhus, she and fellow colleagues developed and started the masters and PhD programmes in nursing science in the early 1990s. Her academic thinking has been shaped and expressed in the academic settings she has been associated with and collaborated with, such as the Danish theological research group associated with K.E. Løgstrup’s thinking, a Nordic network of research on diaconal history, research on nursing, and not least a group working with M. Foucault’s thinking and texts. Martinsen’s authorship embraces phenomenology, ethics and social history. Currently she is working with architecture, philosophy of sensing and the sacred (Løgstrup in relation to heterotopic spaces and traditions of asceticism (Foucault. Martinsen’s style of writing is essay-like, explorative, wondering and unhurried. She has written several books and articles

  5. O jovem Nietzsche leitor de Wagner

    Directory of Open Access Journals (Sweden)

    Hélio Sochodolak

    2011-12-01

    Full Text Available Seguindo as pistas do jovem leitor Nietzsche em sua relação intensa e apaixonada com a música, abordamos historicamente seu envolvimento inicial com a causa wagneriana, no final da década de 1860 e inícios da década de 1870. Nas ideias e escritos de Richard Wagner os anseios nietzscheanos ecoaram em sua busca por um estilo, por uma sonoridade na palavra e por um arrebatamento do leitor. Em sua correspondência e em seus textos, percebemos um jovem filólogo(sofo empolgado, mas, às vezes, desconfiado: Wagner representaria uma alternativa para um novo modelo cultural aos alemães na segunda metade do XIX? O músico poderia ensinar a nação a estabelecer novas relações com a palavra? Poderia ensinar a ler artisticamente?

  6. Ocular manifestations of Hansen's disease.

    Science.gov (United States)

    Sekhar, G C; Vance, G; Otton, S; Kumar, S V; Stanley, J N; Rao, G N

    1994-01-01

    A detailed ophthalmic evaluation including slitlamp biomicroscopy, measurement of corneal sensitivity using Cochet and Bonnet aesthesiometer, Schirmer's test and Goldmann applanation tonometry was carried out in 89 patients of Hansen's disease attending the leprosy clinic with or without ocular symptoms and willing to undergo eye evaluation. Thirty-one patients had lepromatous leprosy (8 with erythema nodosum leprosum), 56 patients had borderline disease (13 with reversal reactions) and 2 had tuberculoid disease. In addition to the well documented changes of lagophthalmos (6.7%), uveitis (7.3%) and cataracts (19%), we noted prominent corneal nerves in 133 eyes (74.7%), beaded corneal nerves in 19 eyes (10.7%), corneal scarring in 10 eyes (5.6%), corneal hypoaesthesia in 51 eyes (28%) and dry eye in 18 eyes (13%). Beaded corneal nerves and/or stomal infiltrates occurred mainly in the lepromatous group (75%). Ocular hypotony (IOP less than 12 mm Hg) was not seen more frequently in Hansen's as compared to age and sex matched controls with refractive errors or cataracts (33.7%, vs. 37.8%, p = 0.33). Our study highlights the primary corneal involvement with corneal neuropathy as the predominant feature of Hansen's disease.

  7. The design, synthesis of amide KARI inhibitors and their biological activities

    Institute of Scientific and Technical Information of China (English)

    Baolei WANG; Yi MA; Yonghong LI; Suhua WANG; Zhengming LI

    2009-01-01

    Ketol-acid reductoisomerase(KARI) is a promising target for the design of herbicides yet there are only few reports on the molecular design of KARI inhibitors. In this paper, based on the reported 0.165 nm high resolution crystal structure of the spinach KARI complex, 279 molecules with low binding energy toward KARI were obtained from an MDL/ACD 3D database search using the program DOCK 4.0. According to the structural information of 279 molecules provided, some amide compounds have been designed and synthesized. The bioassay results show that most of these amides had inhibitory activity to rice KARI at a test concentration of 200 μg/mL. Among which eight amides, compounds 1 and 6 show 57.4% and 48.1% inhibitory activity to KARI. The herbicidal activities of these amides were further investigated on di-cotyledonous rape (Brassica campestris) and mono-cotyledonous bar-nyardgrass (Echinochloa crusgalli). Compounds 1 and 6 were more favorable than others and showed 52.0% and 72.6% inhibitory activity on rape root at 100 μg/mL concentration, respectively. These amides could be further optimized for finding more potent candidates.

  8. Klebsiella ozaenae Septicemia Associated with Hansen's Disease

    Science.gov (United States)

    Murray, Katherine A.; Clements, Bruce H.; Keas, Stephen E.

    1981-01-01

    Two cases of Klebsiella ozaenae septicemia from the National Hansen's Disease Center, Carville, La., are discussed: one fatal and one nonfatal. Although both patients had nasal complications of Hansen's disease (leprosy), the organism was grown initially from spinal fluid, blood, and wound cultures. This report confirms the potential pathogenicity of the K. ozaenae species and its widening disease spectrum. PMID:7037843

  9. Psychosocial aspects of Hansen's disease (leprosy).

    Science.gov (United States)

    Singh, Gurvinder Pal

    2012-09-01

    In general, the prevalence of psychiatric disorders among people with Hansen's disease has greatly increased to date. However, inadequate psychiatric care of people with Hansen's disease is an area of increasing concern. Many studies have been conducted in India and abroad to find out the prevalence of comorbid psychiatric disorders in patients suffering from Hansen's disease. Although efforts have been made by the government and international organizations to solve the medical problems among this group of patients, this disease still carries a number of psychosocial issues. The social stigma connected to these patients makes this disease completely different from others. Even nowadays people affected by Hansen's disease have to leave their village and are socially isolated. Depression is the most common psychiatric disorder found in these patients. Early detection and treatment of psychiatric disorders among Hansen's disease patients is a powerful psychotherapeutic measure. Integrated healthcare strategy will be beneficial to these patients. A comprehensive MEDLINE search and review of relevant literature was carried out and the data extracted and studied with particular reference to psychosocial issues in Hansen's disease. The focus of this research work is related to psychiatric and social aspects vis-à-vis stigma in these patients with Hansen's disease.

  10. Periodontal findings in patients with Hansen's disease.

    Science.gov (United States)

    Ranganathan, Aravindhan Thiruputkuzhi; Khalid, Waleed; Saraswathy, Ponnandai Krishnamurthy; Chandran, Chitraa Rama; Mahalingam, Lakshmiganthan

    2014-09-01

    To find out whether there are any relationship between leprosy and periodontitis as evidenced by clinical parameters. Fifteen diagnosed patients with Hansen's disease were selected and compared against 50 healthy individuals. Clinical parameters like probing pocket depth and clinical attachment level were evaluated for both the groups and the results were subjected to statistical analysis. Mean probing depth and attachment loss is seen more in patients with Hansen's disease than the healthy controls which are statistically significant. Patients with Hansen's disease tend to have more periodontal destruction than the healthy controls. Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  11. Hansen Solubility Parameters for Octahedral Oligomeric Silsesquioxanes

    Science.gov (United States)

    2012-08-28

    and thermal and electrical insulation enhancers. The inorganic core is both mechanically robust, resistant to oxidation, and thermally stable, and...Choi, P.; Kavassalis, T. A.; Rudin, A. Estimation of Hansen Solubility Parameters for (Hydroxyethyl)- Cellulose and (Hydroxypropyl) Cellulose through

  12. [Epidemiology of Hansen's disease in Israel].

    Science.gov (United States)

    Seidenbaum, M; Slater, P E; Ever-Hadani, P; Costin, C; Leviatan, A

    1993-08-01

    There are currently 200 patients with Hansen's disease in Israel who are being followed by the Hansen's Disease Government Hospital and the Ministry of Health (prevalence 4.4/100,000). Most of them immigrated from countries where the disease is endemic. Dermatological findings dominated the initial clinical picture, although 5% of patients are asymptomatic contacts of known cases. Age at onset of disease was less than 20 years in 1/4 of the cases. The incidence in Israel is falling: 0.4/100,000 in 1985-89 compared to 3.6/100,000 in 1950-54. Neurologic and dermatologic findings in an immigrant of any age originating from countries where Hansen's disease is endemic, should prompt appropriate diagnostic evaluation, even years after immigration to Israel. Contacts of known cases of Hansen's disease should be aggressively screened, even if asymptomatic.

  13. Organogel formation rationalized by Hansen solubility parameters.

    Science.gov (United States)

    Raynal, Matthieu; Bouteiller, Laurent

    2011-08-07

    Some organic compounds gelate particular solvents by forming a network of anisotropic fibres. We show that Hansen solubility parameters can be used to predict the range of solvents that are likely to be gelled by any given gelator.

  14. Kerttu Wagner. Die historischen romane von Jaan Kross / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    2001-01-01

    Arvustus: Wagner, Kerttu. Die historischen Romane von Jaan Kross : am Beispiel einer Untersuchung der deutschen und englischen Übersetzungen von "Professor Martensi ärasõit" (1984). Frankfurt am Main [etc.] : P. Lang, 2001.

  15. Kerttu Wagner. Die historischen romane von Jaan Kross / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    2001-01-01

    Arvustus: Wagner, Kerttu. Die historischen Romane von Jaan Kross : am Beispiel einer Untersuchung der deutschen und englischen Übersetzungen von "Professor Martensi ärasõit" (1984). Frankfurt am Main [etc.] : P. Lang, 2001.

  16. Gambaran Histopatologik Lesi Karies pada Email dengan Aplikasi Fluor In Vitro

    Directory of Open Access Journals (Sweden)

    Agoeng Tjahjani

    2015-11-01

    Full Text Available Tahap dini karies telah lama dikenal dengan istilah bercak putih. Untuk mengetahui terjadinya lesi karies di bawah permukaan email in vivo, maka dilakukan penelitian secara in vitro dengan merendam gigi Premolar dengan dan tanpa aplikasi fluor dalam perbenihan kuman Streptococcus mutans FA-1 (ATCC 16495. Enam puluh empat gigi Preolar tanpa karies dibagi dalam 2 kelompok. Pada kelompok perlakuan, gigi diaplikasi dengan fluor sedang pada kelompok kontrol gigi tanpa aplikasi fluor. Semua gigi dimasukkan dalam perbenihan tioglikolat air yang ke dalamnya telah ditanam Streptococcus mutans FA-4 (ATCC 16495 selama 4 dan 8 minggu. Pembentukan bercah putih diamati dengan mikroskop 'zoom-stereo'. Sedang besarnya porusitas di bawah permukaan email diaamti dengan mikroskop polarisasi. Pada akhir minggu ke-4 dan ke-8 pada kedua kelompok ditemukan peningkatan jumlah gigi dengan pembentukan bercak putih dan peningkatan nilai rata-rata kedalaman lapisan badan lesi. Uji statistik dengan chi-square test menunjukkan perbedaan bermakna pada p<0.05. Berdasarkan penelitian tersebut di atas disimpulkan bahwa (1 aplikasi NaF hanya menghambat sebagian pembentukan lesi karies dan (2 sistem perbenihan kuman yang digunakan tidak dapat mencerminkan keadaan mulut yang sebenarnya.

  17. Väitlus : vastuseks eelolevale / Enn Küng, Kari Tarkiainen, Ülle Tarkiainen

    Index Scriptorium Estoniae

    Küng, Enn, 1963-

    2015-01-01

    Väitlus Enn Küngi ning Kari ja Ülle Tarkiaineni vahel, mille aluseks on 2015. a. Akadeemia 8. numbris ilmunud Enn Küngi arvustis Tarkiainenite raamatule "Provinsen bortom havet. Estlands svenska historia 1561-1710" (Lk. 1491-1499)

  18. Väitlus : vastuseks eelolevale / Enn Küng, Kari Tarkiainen, Ülle Tarkiainen

    Index Scriptorium Estoniae

    Küng, Enn, 1963-

    2015-01-01

    Väitlus Enn Küngi ning Kari ja Ülle Tarkiaineni vahel, mille aluseks on 2015. a. Akadeemia 8. numbris ilmunud Enn Küngi arvustis Tarkiainenite raamatule "Provinsen bortom havet. Estlands svenska historia 1561-1710" (Lk. 1491-1499)

  19. Perception of Leitmotives in Richard Wagner's Der Ring des Nibelungen.

    Science.gov (United States)

    Baker, David J; Müllensiefen, Daniel

    2017-01-01

    The music of Richard Wagner tends to generate very diverse judgments indicative of the complex relationship between listeners and the sophisticated musical structures in Wagner's music. This paper presents findings from two listening experiments using the music from Wagner's Der Ring des Nibelungen that explores musical as well as individual listener parameters to better understand how listeners are able to hear leitmotives, a compositional device closely associated with Wagner's music. Results confirm findings from a previous experiment showing that specific expertise with Wagner's music can account for a greater portion of the variance in an individual's ability to recognize and remember musical material compared to measures of generic musical training. Results also explore how acoustical distance of the leitmotives affects memory recognition using a chroma similarity measure. In addition, we show how characteristics of the compositional structure of the leitmotives contributes to their salience and memorability. A final model is then presented that accounts for the aforementioned individual differences factors, as well as parameters of musical surface and structure. Our results suggest that that future work in music perception may consider both individual differences variables beyond musical training, as well as symbolic features and audio commonly used in music information retrieval in order to build robust models of musical perception and cognition.

  20. Perception of Leitmotives in Richard Wagner's Der Ring des Nibelungen

    Directory of Open Access Journals (Sweden)

    David J. Baker

    2017-05-01

    Full Text Available The music of Richard Wagner tends to generate very diverse judgments indicative of the complex relationship between listeners and the sophisticated musical structures in Wagner's music. This paper presents findings from two listening experiments using the music from Wagner's Der Ring des Nibelungen that explores musical as well as individual listener parameters to better understand how listeners are able to hear leitmotives, a compositional device closely associated with Wagner's music. Results confirm findings from a previous experiment showing that specific expertise with Wagner's music can account for a greater portion of the variance in an individual's ability to recognize and remember musical material compared to measures of generic musical training. Results also explore how acoustical distance of the leitmotives affects memory recognition using a chroma similarity measure. In addition, we show how characteristics of the compositional structure of the leitmotives contributes to their salience and memorability. A final model is then presented that accounts for the aforementioned individual differences factors, as well as parameters of musical surface and structure. Our results suggest that that future work in music perception may consider both individual differences variables beyond musical training, as well as symbolic features and audio commonly used in music information retrieval in order to build robust models of musical perception and cognition.

  1. Põllumajandusülikooli rektoriks sai ülekaalukalt Alar Karis / Anu Mõistlik, Jüri Saar

    Index Scriptorium Estoniae

    Mõistlik, Anu

    2002-01-01

    18. detsembril 2002. a. valis Eesti Põllumajandusülikool suure häälteenamusega uueks rektoriks senise Tartu Ülikooli erizooloogia professori Alar Karise, kes annab ametivande 19. detsembril 2002. a. Valimiskõnes nimetas Karis tähtsate eesmärkidena arendada põllumajandusülikoolist Läänemere regiooni arvestatav ülikool ning meelitada sinna õppima erialast tõeliselt huvitatud tudengid. Prorektorikandidaatide nimesid ei olnud Karis veel valmis nimetama

  2. Põllumajandusülikooli rektoriks sai ülekaalukalt Alar Karis / Anu Mõistlik, Jüri Saar

    Index Scriptorium Estoniae

    Mõistlik, Anu

    2002-01-01

    18. detsembril 2002. a. valis Eesti Põllumajandusülikool suure häälteenamusega uueks rektoriks senise Tartu Ülikooli erizooloogia professori Alar Karise, kes annab ametivande 19. detsembril 2002. a. Valimiskõnes nimetas Karis tähtsate eesmärkidena arendada põllumajandusülikoolist Läänemere regiooni arvestatav ülikool ning meelitada sinna õppima erialast tõeliselt huvitatud tudengid. Prorektorikandidaatide nimesid ei olnud Karis veel valmis nimetama

  3. A Reply to Hansen's Cultural Humanism

    Science.gov (United States)

    Lemberger, Matthew E.

    2012-01-01

    Hansen (2012b) responds to the author's (Lemberger, 2012) critique of his humanistic vision by dividing their arguments as either individual or cultural in design. In this reply, the author contends that the individual cannot be extracted from her or his culture and, therefore, what is sufficient for a humanistic counseling culture must also be…

  4. A Reply to Hansen's Cultural Humanism

    Science.gov (United States)

    Lemberger, Matthew E.

    2012-01-01

    Hansen (2012b) responds to the author's (Lemberger, 2012) critique of his humanistic vision by dividing their arguments as either individual or cultural in design. In this reply, the author contends that the individual cannot be extracted from her or his culture and, therefore, what is sufficient for a humanistic counseling culture must also be…

  5. Application of Yamaguchi's technique for the Rescorla-Wagner model.

    Science.gov (United States)

    Yamaguchi, Makoto

    2007-12-01

    Yamaguchi in 2006 solved for the first time a problem concerning a 1972 mathematical model of classical conditioning by Rescorla and Wagner. That derivation is not an isolated contribution. Here it is shown that the same line of derivation can be successfully applied to another experimental situation involving more stimuli.

  6. Transitioning Students out of College: The Senior LC in Psychology at Wagner College

    Science.gov (United States)

    Nolan, Laurence J.; Jenkins, Steve M.

    2012-01-01

    At Wagner College, students are required to participate in a series of three curriculum-based learning communities (C-BLCs) as the core of the undergraduate curriculum known as the Wagner Plan for the Practical Liberal Arts. This article describes the senior learning community (LC) in psychology at Wagner College, which is an example of a…

  7. [Immune response of Hansen's disease. Review].

    Science.gov (United States)

    Rada, Elsa; Aranzazu, Nacarid; Convit, Jacinto

    2009-12-01

    Hansen's disease presents a wide spectrum of clinical and histopathological manifestations that reflect the nature of the immunological response of the host towards diverse Mycobacterium leprae components. The immunological system, composed by both innate and adaptive immunology, offers protection towards infections of various etiologies, among them bacterial. Bacteria, of course, have developed multiple strategies for evading host defenses, based on either very complex or simple mechanisms, but with a single purpose: to "resist" host attacks and to be able to survive. We have tried to summarize some recent studies in Hansen's disease, with more emphasis in the inmunology area. We think that in the future, all illnesses should also be very strongly related to other important aspects such as the social, environmental and economic, and whose development is not solved in a laboratory.

  8. 42 CFR 32.91 - Purchase of services for Hansen's disease patients.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Purchase of services for Hansen's disease patients... MEDICAL CARE AND EXAMINATIONS MEDICAL CARE FOR PERSONS WITH HANSEN'S DISEASE AND OTHER PERSONS IN EMERGENCIES Persons with Hansen's Disease § 32.91 Purchase of services for Hansen's disease patients. Hansen's...

  9. Hansen's disease mimicking a systemic vasculitis.

    Science.gov (United States)

    Sampaio, L; Silva, L; Terroso, G; Pimenta, S; Brandão, F; Pinto, J; Prisca, A; Brito, J; Ventura, F

    2011-01-01

    Hansen's disease, caused by Mycobacterium leprae, classically presents with cutaneous and neurological manifestations. Rheumatologic manifestations present in 1 to 5% of the patients, and include arthritis, arthralgias, Charcot arthropathy, erythema nodosum and vasculitis. We report a case of a 86 year old woman with polyarthritis, subcutaneous nodules and leg ulcers whose differential diagnosis included primary vasculitis and diffuse connective tissue diseases and ended to be leprosy in a non endemic country.

  10. Perception of Leitmotives in Richard Wagner's Der Ring des Nibelungen

    OpenAIRE

    Baker, David J.; Müllensiefen, Daniel

    2017-01-01

    The music of Richard Wagner tends to generate very diverse judgments indicative of the complex relationship between listeners and the sophisticated musical structures in Wagner’s music. This paper presents findings from two listening experiments using the music from Wagner’s Der Ring des Nibelungen that explores musical as well as individual listener parameters to better understand how listeners are able to hear leitmotives, a compositional device closely associated with Wagner’s music. Resul...

  11. Use of Hansen Solubility Parameters in Fuel Treatment Processes

    Science.gov (United States)

    2014-03-17

    Charts 3. DATES COVERED (From - To) Jan 2014- Mar 2014 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER In-House Use of Hansen Solubility Parameters in...distribution is unlimited. AFRL Public Affairs Clearance # USE OF HANSEN SOLUBILITY PARAMETERS IN FUEL TREATMENT PROCESSES 17 March 2014 Andrew J...Treatment Needs – Hansen Solubility Parameters • Dyes – Experimental HSP Determination – Extrapolation to Other Dyes • Predictions for Extraction Fluids

  12. Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses.

    Science.gov (United States)

    Schwarz, O.; Strumpf, M.

    The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. The authors present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

  13. Pencegahan Karies pada Pit dan Fisura Gigi Molar Pertama Tetap dengan Semen Glass Ionomer Type III (Studi Pustaka

    Directory of Open Access Journals (Sweden)

    Titi Pratiwi Indra Yoga

    2015-11-01

    Full Text Available Gigi molar pertama tetap merupakan gigi yang penting untuk oklusi sehingga diharapkan dapat bertahan seumur hidup. Tetapi karena erupsi pada anak umur 5-6 tahun yang kemampuan untuk membersihkan gigi masih terbatas dan seringkali mempunyai pit dan fisura yang dalam sehingga sukar dibersihkan maka kemungkinan terserang karies lebih besar daripada gigi yang lain. Berbagai cara telah dilakukan untuk mencegah karies pada gigi molar pertama tetap, diantaranya dengan menutup pit dan fisura gigi tersebut dengan semen glass-ionomer. Keuntungan pemakaian semen glass-ionomer ialah selain menutup pit dan fisura gigi molar pertama tetap juga tidak mengiritasi pulpa karena tidak memakai teknik etsa email serta mempunyai sifat anti kariogenik.

  14. O Beethoven-Schrift: Richard Wagner teórico The Beethoven-Schrift: theoretical Richard Wagner

    Directory of Open Access Journals (Sweden)

    Henry Burnett

    2009-01-01

    Full Text Available Quando consideramos a extensão da obra dramática de Richard Wagner, não causa estranheza que seus textos teóricos sejam praticamente desconhecidos. No entanto, um de seus escritos, intitulado Beethoven, influenciou decisivamente a elaboração de um livro famoso, hoje considerado um capítulo importante da história da estética, O nascimento da tragédia. Este artigo pretende analisar este escrito de Wagner na intenção de desvendar o que pode ter sido tão determinante na leitura que Nietzsche fez dele, e que o levou ao ponto de citá-lo de modo efusivo no primeiro prefácio da sua obra de estréia, dedicado àquele que, até então, era seu grande mestre e amigo e, como veremos, uma influência não só musical, mas também teórica.If we consider the magnitude of the Richard Wagner's dramatic work, it will be not strange to realize that his theoretical texts are almost entirely unknown. However, one of his writings, entitled Beethoven, exercised decisive influence upon the composition of The birth of tragedy, a famous book regarded nowadays as an essential moment of the history of aesthetics. The purpose of this paper is to examine this Wagner's writing aiming to unriddle which determinative motive brought Nietzsche to mention it enthusiastically in the original foreword of his first work, dedicated to whom which, until that moment, were his master and friend and exercised upon him an influence both musical and theoretical.

  15. Förekomst av karies och parodontit hos personer med Morbus Crohn

    OpenAIRE

    Johansson, Annika; Olsson, Sara

    2012-01-01

    Syftet med litteraturstudien var att undersöka förekomsten av karies och parodontit hos personer med Morbus Crohn. Metoden som användes var en allmän litteraturstudie. Materialet till litteraturstudien samlades in genom sökning i databaserna Cinahl, PubMed och ScienceDirect. De sökord som användes vid litteratursökningen i samtliga databaser var ”caries”, ”Crohn’s disease”, ”periodontal disease” och ”periodontitis”. Vetenskapliga artiklar som fick ingå i litteraturstudien begränsades till ”En...

  16. GAMBARAN KARIES GIGI PERMANEN DI BEBERAPA PUSKESMAS KOTA DAN KABUPATEN BANDUNG, SUKABUMI SERTA BOGOR TAHUN 2002

    Directory of Open Access Journals (Sweden)

    Indirawati Tjahja N.

    2012-10-01

    Full Text Available Penyakit gigi dan mulut merupakan masalah utama yang diderita oleh 90% penduduk di Indonesia. Penyakit ini cenderung meningkat, bila tidak dilakukan perawatan maka akan semakin parah. Penyakit gigi dan mulut yang banyak ditemukan di masyarakat adalah penyakit karies gigi. Penelitian ini dilakukan selama 10 bulan, dengan disain penelitian cross sectional. Penelitian dilakukan di puskesmas kota dan kabupaten Bandung, kota dan kabupaten Sukabumi serta kota dan kabupaten Bogor. Jumlah sampel 240 orang, masing-masing puskesmas 40 orang. Pengumpulan data dilakukan pemeriksaan status kesehatan gigi dan mulut serta wawancara. Didapatkan nilai DMF-T bervariasi, pada usia 12 tahun, umumnya berkisar antara (5,5 -7,29 kecuali kota Bandung dan kota Bogor bemilai (2,00 dan 4,4. Dapat disimpulkan nilai DMF-T pada usia 12 tahun, di kabupaten Bandung, kota, kabupaten Sukabumi serta kabupaten Bogor bemilai tinggi, sedang nilai DMF-T di kota Bandung bemilai rendah, sedangkan kota Bogor nilai DMF-T nya bernilai sedang.   Kata kunci: karies, gigi dan mulut

  17. GAMBARAN PERILAKU MENGGOSOK GIGI TERHADAP KEJADIAN KARIES GIGI PADA ANAK USIA SEKOLAH DASAR DI WILAYAH KERJA PUSKESMAS SIDEMEN, KECAMATAN SIDEMEN, KABUPATEN KARANGASEM, PADA JUNI-JULI 2013

    Directory of Open Access Journals (Sweden)

    Desak Made Dwi Ambari Ningsih

    2015-04-01

    Full Text Available Kesehatan gigi masih menjadi masalah di Indonesia dilihat dari prevalensi karies gigi yang mencapai 73% dari jumlah penduduk. Di Puskesmas Sidemen, penyakit gigi, gusi dan pulpa merupakan urutan keempat dari 10 besar penyakit yang paling sering terjadi. Adanya fakta bahwa ketersediaan air bersih, sikat gigi dan pasta gigi di daerah Sidemen tidak sulit diperoleh, menunjukkan adanya faktor lain yang mempengaruhi tingginya kejadian karies gigi, misalnya perilaku menggosok gigi dan juga pengetahuan  orang tua dan anak terhadap karies gigi.  Penelitian ini bertujuan untuk mengetahui prevalensi karies gigi, perilaku menggosok gigi, dan gambaran perilaku menggosok gigi terhadap kejadian karies gigi pada siswa usia sekolah dasar di wilayah Puskesmas Sidemen, Kecamatan Sidemen, Kabupaten Karangasem. Penelitian ini merupakan penelitian deskriptif potong-lintang yang dilakukan pada bulan Juni sampai dengan Juli 2013. Penelitian ini menggunakan 68 orang sampel yang ditentukan secara purposive random sampling pada siswa usia 7 hingga 12 tahun di SD Negeri 1 Telagatawang. Pada penelitian ini, didapatkan prevalensi karies gigi pada anak usia sekolah dasar di wilayah kerja Puskesmas Sidemen  masih tinggi (58,8%. Sebanyak 58 orang (85,3% belum menerapkan perilaku menggosok gigi yang memenuhi standar dan hanya 10 orang (14,7% yang perilaku menggosok gigi sudah memenuhi standar. Karies gigi lebih banyak dialami oleh anak-anak yang tidak memenuhi standar dalam perilaku menggosok gigi, yaitu sebanyak 63,8% (37 orang dari total 58 orang yang perilaku menggosok gigi tidak memenuhi standar. Sedangkan dari 10 orang yang memenuhi standar perilaku menggosok ternyata didapatkan sebagian besar, yaitu 7 orang (70% tidak karies. Sehingga secara umum dari penelitian ini dapat ditarik simpulan bahwa terdapat kecenderungan peningkatan presentase kejadian karies gigi pada anak dengan perilaku menggosok gigi yang salah dibandingkan yang benar.    

  18. Closed loop identification using a modified Hansen scheme

    DEFF Research Database (Denmark)

    Sekunda, André Krabdrup; Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2015-01-01

    in closed loop [4], and one such method is the Hansen scheme [1]. Standard identification using Hansen scheme demands generating the identification signals indirectly. In this paper it is instead proposed to use the relationship between the Youla factorization of a plant and its stabilizing controller...

  19. How much Schopenhauer is there really in Wagner?

    Directory of Open Access Journals (Sweden)

    Alessandro Pinzani

    2012-09-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2012v11nesp1p211 The paper aims at analyzing some Wagnerian figures in order to show that the influence of Schopenhauer’s philosophy on Wagner is not as strong as commonly held – at least not in his operas. The figures that shall be considered are: Wotan and Brünnhilde, Tristan and Isolde, and finally Parsifal, who appears to be the only Schopenhauerian character of all.

  20. A synopsis of the history of Hansen's disease.

    Science.gov (United States)

    Couto Dal Secco, Raissa Gonçalves; França, Katlein; Castillo, David; AlHarbi, Mana; Lotti, Torello; Fioranelli, Massimo; Roccia, Maria Grazia

    2017-08-11

    Leprosy is a contagious infectious disease caused by the bacillus Mycobacterium leprae. This microorganism was discovered by Dr. Gerhard Hansen, and the illness was then baptized as Hansen's disease. For a long time, Hansen's disease was thought to be hereditary-a curse or a punishment from God. The disease affects skin and nerves and can cause severe damage. Due to its destructive effects, leprosy has caused fear, segregation, and prejudice in all societies since Biblical times. Patients with Hansen's disease have not been treated humanely around the world throughout the ages. This article is a summary of curious and interesting facts about the history and cultural aspects of Hansen's disease, which has chastised humanity for centuries. These facts are about the discovery of the disease, its propagation, the evolution of treatments, and the prejudice of society towards patients.

  1. Faktor Risiko Terjadinya Karies Baru dengan Pendekatan Kariogram pada Pasien Anak di Klinik Kedokteran Gigi Anak RSGMP Prof. Soedomo Yogyakarta

    Directory of Open Access Journals (Sweden)

    Putri Kusuma Wardani

    2012-12-01

    Full Text Available Latar belakang. Faktor risiko karies adalah faktor yang berhubungan dengan kejadian karies pada individu dan populasi. Faktor risiko karies berbeda antar individu. Untuk menggambarkan interaksi antara faktor-faktor yang berhubungan dengan karies digunakan kariogram. Tujuan. Penelitian ini adalah untuk mendapatkan gambaran urutan faktor risiko karies dengan pendekatan kariogram pada pasien anak di klinik Kedokteran Gigi Anak RSGMP Prof. Soedomo. Metode. Subjek terdiri dari 26 anak dalam periode gigi-geligi bercampur. Dilakukan pemeriksaan tentang pengalaman karies, riwayat penyakit sistemik, frekuensi makan, skor plak, aktivitas Streptococcus mutans, volume sekresi saliva, pH saliva dan program fluoridasi. Hasil pemeriksaan dianalisis menggunakan program kariogram. Hasil. Penelitian menunjukkan bahwa rerata persentase faktor bakteri adalah 21,1%, faktor pola makan: 18,1%, faktor kerentanan gigi: 16,1% dan faktor lain-lain: 9,5%. Kesimpulan. Dapat disimpulkan bahwa urutan faktor risiko karies dengan pendekatan kariogram adalah bakteri, pola makan, kerentanan gigi dan faktor lain-lain.   Background. Caries risk factor is factor related with caries incidence in individu and population. The caries risk factor is different between individu. For illustrating the interaction between caries related factors may be used cariogram. Aim. The aim of this research was to find out the sequence of caries risk factors from cariogram on children patients at the Clinic of Pediatric Dentistry Prof. Soedomo dental hospital. Method. Subjects were comprised 26 children in the periode of mixed dentition. Examinations were included: experience of caries, the history of systemic disease, daily meal frequency, plaque scoring, activity of Streptococcus mutans, the volume of saliva secretion, pH of saliva, and the participations of fluoridation program. The examination result were analyzed with programme cariogram. Result. The result showed that the mean of percentage

  2. HUBUNGAN STATUS SOSIAL EKONOMI ORANG TUA DENGAN KARIES PADA GIGI SULUNG ANAK UMUR 4 DAN 5 TAHUN

    Directory of Open Access Journals (Sweden)

    Susi Susi

    2012-05-01

    Full Text Available AbstrakKaries merupakan masalah utama di rongga mulut anak. Kerusakan gigi sulung lebih cepat menyebar, meluas dan lebih parah dari pada gigi permanen. Karies lebih banyak ditemukan pada orang dengan status sosial ekonomi rendah. Tujuan dari penelitian ini adalah untuk mengetahui hubungan status sosial ekonomi dengan kejadian karies pada gigi sulung anak usia 4 dan 5 tahun pada murid TK Adzkia II, TK Lillah, dan TK Mutiara Ananda di Kota Padang.Penelitian ini bersifat observasi analitik menggunakan metode cross sectional. Populasi penelitian ini adalah murid TK Adzkia II, TK Lillah, dan TK Mutiara Ananda yang berumur 4-5 tahun atau murid lokal A yang berjumlah sebanyak 59 orang, sampel yang diteliti 57 orang. Metode pengambilan data primer yaitu dengan melakukan wawancara dengan orang tua dan pemeriksaan status karies responden.Hasil penelitian menunjukkan status sosial ekonomi orang tua dari responden 75,4% tidak miskin dan status karies responden 50,9% baik. Dari responden yang tidak miskin, 46,5% memiliki status karies yang buruk, 53,5% memiliki status karies yang baik. Hasil uji statistik diperoleh tidak ada hubungan yang bermakna dari proporsi status karies responden dengan pendapatan orang tua responden.Dari penelitian ini dapat disimpulkan bahwa responden dengan status sosial ekonomi tidak miskin dan status karies baik lebih dominan. Disarankan kepada sekolah agar memberikan pengetahuan tentang kesehatan gigi dan mulut secara rutin kepada murid – murid dan bagi orang tua lebih memperhatikan jajanan yang dikonsumsi oleh anaknya.Kata Kunci : karies, status sosial ekonomiAbstractCaries is a major issue in the oral cavity of children. Damage spreading deciduous teeth faster, more widespread and severe than in permanent teeth. Caries are more common in people with low socioeconomic status. The purpose of this study was to determine the relationship of socioeconomic parents status with the incidence of caries in primary teeth of kindergarten

  3. W. W. Hansen, Microwave Physics, and Silicon Valley

    Science.gov (United States)

    Leeson, David

    2009-03-01

    The Stanford physicist W. W. Hansen (b. 1909, AB '29 and PhD '32, MIT post-doc 1933-4, Prof. physics '35-'49, d. 1949) played a seminal role in the development of microwave electronics. His contributions underlay Silicon Valley's postwar ``microwave'' phase, when numerous companies, acknowledging their unique scientific debt to Hansen, flourished around Stanford University. As had the prewar ``radio'' companies, they furthered the regional entrepreneurial culture and prepared the ground for the later semiconductor and computer developments we know as Silicon Valley. In the 1930's, Hansen invented the cavity resonator. He applied this to his concept of the radio-frequency (RF) linear accelerator and, with the Varian brothers, to the invention of the klystron, which made microwave radar practical. As WWII loomed, Hansen was asked to lecture on microwaves to the physicists recruited to the MIT Radiation Laboratory. Hansen's ``Notes on Microwaves,'' the Rad Lab ``bible'' on the subject, had a seminal impact on subsequent works, including the Rad Lab Series. Because of Hansen's failing health, his postwar work, and MIT-Stanford rivalries, the Notes were never published, languishing as an underground classic. I have located remaining copies, and will publish the Notes with a biography honoring the centenary of Hansen's birth. After the war, Hansen founded Stanford's Microwave Laboratory to develop powerful klystrons and linear accelerators. He collaborated with Felix Bloch in the discovery of nuclear magnetic resonance. Hansen experienced first-hand Stanford's evolution from its depression-era physics department to corporate, then government funding. Hansen's brilliant career was cut short by his death in 1949, after his induction in the National Academy of Sciences. His ideas were carried on in Stanford's two-mile long linear accelerator and the development of Silicon Valley.

  4. The diagnostic challenge of Hansen's disease.

    Science.gov (United States)

    Chambers, James A; Baffi, Cynthia W; Nash, Kevin T

    2009-06-01

    Hansen's disease (HD), formerly referred to as leprosy, actively infects more than 250,000 persons worldwide, with over 2 million currently being treated for sequelae. Over 150 cases are annually reported in the U.S. Although transmission of Hansen's disease to military personnel is rare, physicians caring for those who deploy abroad should be aware of the diagnostic challenges and therapeutic aspects of the disease, as well as its implication for continued military service. Additionally, with U.S. involvement in humanitarian efforts abroad, many military physicians will encounter this condition in indigenous populations. Because of its relative rarity in the U.S. and its protean manifestations, diagnosis is generally delayed 6-12 months, leading to potentially irreversible sequelae. Therefore the clinician should be aware of the presentation of HD as well as the key steps to procuring a diagnosis. This paper reports a case of HD encountered in an active duty, native-born U.S. Air Force aviator.

  5. Muusikamaailm : Lihavõttemuusikat siit ja sealt. Los Angelese Ooperi plaanid. Bayreuthi tuleb Eva Wagner

    Index Scriptorium Estoniae

    2001-01-01

    Salzburgi lihavõttefestivalist, lihavõttekavast New Yorgi Metropolitan Operas ja Roomas. Tulevikukavadest Los Angelese Ooperis. Bayreuthi ooerpifestivali uueks kunstiliseks juhiks valiti E.Wagner-Pasquier

  6. Muusikamaailm : Lihavõttemuusikat siit ja sealt. Los Angelese Ooperi plaanid. Bayreuthi tuleb Eva Wagner

    Index Scriptorium Estoniae

    2001-01-01

    Salzburgi lihavõttefestivalist, lihavõttekavast New Yorgi Metropolitan Operas ja Roomas. Tulevikukavadest Los Angelese Ooperis. Bayreuthi ooerpifestivali uueks kunstiliseks juhiks valiti E.Wagner-Pasquier

  7. Von Tondern nach Gotha. Der Astronom Peter Andreas Hansen, 1795 - 1874.

    Science.gov (United States)

    Strumpf, M.; Pehlemann, E.; Wolfschmidt, G.

    This companion booklet to an exposition in honor of Peter Andreas Hansen's 200th birthday contains three papers. Contents: 1. Peter Andreas Hansen - Leben und Wirken in Gotha (M. Strumpf). 2. Peter Andreas Hansens wissenschaftliches Werk (E. Pehlemann). 3. Beobachtungsinstrumente der Sternwarte Gotha zur Zeit Hansens (G. Wolfschmidt).

  8. Perbedaan status oral higiene dan pengalaman karies gigi pada penderita dan bukan penderita asma usia 20-30 tahun di RSUP H.Adam Malik Medan

    OpenAIRE

    Balakrishnan, Tirumagal

    2015-01-01

    Asma merupakan penyakit inflamasi kronis pada saluran pernafasan yang ditandai rasa sesak di dada akibat penyumbatan saluran pernafasan. Asma merupakan salah satu penyakit yang dapat berperan sebagai faktor risiko karies gigi. Penelitian ini bertujuan untuk mengetahui status oral higiene dan pengalaman karies pada penderita asma. Rancangan penelitian adalah case-control. Populasi penelitian ini adalah penderita asma yang sedang berobat di Poli Pulmonologi (Asma) sedangkan sebagai kontrol, yai...

  9. Kommentar til Illum-Hansen og Misfeldt

    DEFF Research Database (Denmark)

    Holst, Finn

    2014-01-01

    Illum-Hansen and Misfeldt compare the role of ICT-didactics within subject-specific domains. They demonstrate that different school subjects (here native language and mathematics) seem to be dominated by different paradigms and prototypes related to ICT didactics. A comparative subject-didactic...... approach is seen as a possibility to develop the understanding of different forms of integration of ICT and subject didactics. I suggest that a further investigation along this line could be based on a closer analysis of different combinations and integrations of subject, technology and pedagogics. Subject-didactics......’ makes it considerably more complicated to develop an integrated ICT-subject-didactics. In order to meet this challenge, the construction of an analytical typology is suggested in which forms of combinations and integrations are based on this triad. As a contribution to comparative subject-didactics...

  10. Hansen's disease associated with erythromelalgia mimicking Lupus erythematosus.

    Science.gov (United States)

    Damodar, Shenoi Shrutakirthi; Smitha, Prabhu; Nirmal, Balakrishnan; Sudhir, Nayak U K; Ballambat, Pai Sathish

    2014-01-01

    Hansen's disease, though considered to be at the verge of elimination in many countries including India, still continues to surprise patients and dermatologists alike. This is mainly due to its varying and unconventional presentations which may lead to initial misdiagnosis and prolongation of treatment. Here we describe an unusual case presenting with erythematous photosensitive facial lesions associated with erythromelalgia of the finger tips, provisionally diagnosed as SLE. A subsequent histopathology examination proved it to be Hansens' disease Borderline Tuberculoid variety. Hansen's disease can be termed as the modern great imitator, displacing the traditional great imitator, syphilis.

  11. A Teutonic ethnologist in the Windhoek district : rethinking the anthropology of Guenther Wagner

    NARCIS (Netherlands)

    Gewald, J.B.; LeBeau, D.; Gordon, R.J.

    2002-01-01

    This chapter reviews the history of anthropology in Namibia, focusing on the work of Guenther Kurt F. Wagner, who was appointed as Assistant Government Anthropologist for South West Africa in 1949. Wagner's unpublished work, 'Ethnographic survey of the Windhoek district' (1951), shows that Windhoek

  12. Kadar leptin saliva dan kejadian karies gigi anak obesitas (Salivary leptin levels and caries incidence in obese children

    Directory of Open Access Journals (Sweden)

    Elfrida Atzmaryanni

    2013-09-01

    Full Text Available Background: Children with obesity have a lower incidence of caries. Salivary leptin levels of obese children is higher than normal children. Leptin is protein hormone, contained in saliva. Salivary proteins maintain the balance of the ecosystem in the mouth. Purpose: The article was aimed to study the correlation of salivary leptin levels with caries incidence in obese children. Review: Mouth is reflection of the health status and so many changes occur as a weight gain. Child with obesity has a low incidence of caries than normal. This condition is associated with changes in oral cavity, especially the increase in salivary leptin. Caries is a disease of hard tissues cause by the activty of microorganisms, especially Streptococcus mutans. Salivary proteins maintain the balance of the ecosystem in the mouth. Leptin is a protein saliva, produced predominantly in adipose tissue and conduct active transport to saliva. Salivary leptin works in two ways: as an antimicrobial which prevents the attachment of bacteria on tooth surface or by inducing cytokine that affect the immune system in oral cavity. Conclusion: Salivary leptin is higher in obese children than in normal children. The low incidence of caries on obesity is associated with salivary leptin. Alteration in salivary composition and flow rate also decreased caries in obesity.Latar belakang: Anak yang mengalami obesitas memiliki insiden karies yang rendah. Kadar leptin saliva anak obesitas lebih tinggi dari anak normal. Leptin merupakan salah satu protein hormon yang terdapat di saliva. Protein saliva berfungsi untuk menjaga keseimbangan ekosistem di mulut. Tujuan: Artikel ini bertujuan mempelajari hubungan antara kadar leptin di dalam saliva dengan kejadian karies anak obesitas. Tinjauan pustaka: Rongga mulut merupakan cerminan dari status kesehatan dan banyak perubahan yang terjadi seiring peningkatan berat badan seseorang. Anak Obesitas memiliki insiden karies yang rendah jika dibandingkan

  13. Die doppelte Triade: Wotan - Loge - Erda/Wagner - Freud - Butler

    Directory of Open Access Journals (Sweden)

    Simone Fohr-Manthey

    2012-05-01

    Full Text Available This essay offers a reading of Richard Wagner’s Rhinegold as a work in which important tendencies of modernity are prefigured in the opera’s narratological and vocal dispositions. These tendencies are, first of all, the destabilization of an intact identity and, second, the Freudian-based concept of the three aspects of the psyche, the id, the ego, and the super-ego, which govern the individual self. A third focus is on Wagner’s ideas of an androgynous system beyond the dualism of maleness/femaleness, as described by Judith Butler. With these premises, an analysis of the opera’s dramatic function and vocal parts for the characters Wotan, Loge, and Erda shows whether Richard Wagner, as an author-composer of the late nineteenth century, can be regarded as a protomodernist and thus a pacesetter for modernity.

  14. On Global Stability for Lifschitz-Slyozov-Wagner like equations

    CERN Document Server

    Conlon, Joseph G

    2011-01-01

    This paper is concerned with the stability and asymptotic stability at large time of solutions to a system of equations, which includes the Lifschitz-Slyozov-Wagner (LSW) system in the case when the initial data has compact support. The main result of the paper is a proof of weak global asymptotic stability for LSW like systems. Previously strong local asymptotic stability results were obtained by Niethammer and Vel\\'{a}zquez for the LSW system with initial data of compact support. Comparison to a quadratic model plays an important part in the proof of the main theorem when the initial data is critical. The quadratic model extends the linear model of Carr and Penrose, and has a time invariant solution which decays exponentially at the edge of its support in the same way as the infinitely differentiable self-similar solution of the LSW model.

  15. Influences of ancient Greek spirit on music romanticism as exemplifies in Richard Wagner's Gesamtkunstwerk

    Directory of Open Access Journals (Sweden)

    Siopsi Anastasia

    2005-01-01

    Full Text Available The romantics' ideal of the arts' collaboration (Mischgedichte finds its most substantial equivalent in Richard Wagner's (1813-1883 "total work of art" (Gesamtkunstwerk. This theory for the restoration of the 'lost' unity of arts was elaborated in many theoretical essays of Wagner and 'applied' in his music dramas. Unity of arts, as well as unity of arts with nature existed according to Wagner in Ancient Greece while drama was the epitome of all expressive elements of nature. This "new art of the future", which Wagner envisaged, would restore the 'wholeness' of ancient Greek drama. It is the purpose, therefore, of this study to analyze mainly from an aesthetic point of view the influences of ancient Greek spirit on romantic thought, by focusing on Wagner's work.

  16. Genética e hanseníase

    Directory of Open Access Journals (Sweden)

    Bernardo Beiguelman

    Full Text Available As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e estudos genéticos sobre a reação de Mitsuda.

  17. Kõik on võimalik! / Mae Hansen ; interv. Jaana Liigand

    Index Scriptorium Estoniae

    Hansen, Mae

    2006-01-01

    Sampo Panga Lõuna-Eesti regiooni juht oma finantsalase hariduse omandamisest USA-s, Ameerika ja Eesti ühiskondade erinevustest, eduka juhtimise vahenditest, eeskujudest ning tulevikuplaanidest. Lisa: Mae Hansen

  18. Hansen's disease with McCune-Albright syndrome.

    Science.gov (United States)

    Kumar, Kvs Hari; Dhull, P; Bisht, Ys

    2012-10-01

    McCune-Albright syndrome (MAS) comprises a triad of fibrous dysplasia of bone, café-au-lait macule, and endocrinopathy. The disease is due to activating mutation of G protein-coupled receptor leading to hyperfunction of glands. Hansen's disease is caused by infection with Mycobacterium leprae and is seen with underlying immunosuppressed conditions in genetically predisposed individuals. We recently encountered a patient with Hansen's disease along with underlying MAS and report the same in this report.

  19. Peter Andreas Hansen and the astronomical community - a first investigation of the Hansen papers. (German Title: Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses. )

    Science.gov (United States)

    Schwarz, Oliver; Strumpf, Manfred

    The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. We present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

  20. Símbolo y forma: los hermanos Grimm en Richard Wagner

    OpenAIRE

    Miguel Salmerón Infante

    2015-01-01

    This paper examines how and why Grimm´s Tales are present in Richard Wagner´s works. Providing with a more specific approach to this reflection, this analysis focusses on Siegfried, the densest Wagner´s Musical drama according fairy tales atmosphere in his opera omnia, and the influences and the thematical, formal and linguistical appropiations from the KHM, already studied. The article gives for granted that there are two elements used by Wagner in his musical dramas: symbols for the articul...

  1. Símbolo y forma: los hermanos Grimm en Richard Wagner

    OpenAIRE

    Miguel Salmerón Infante

    2015-01-01

    This paper examines how and why Grimm´s Tales are present in Richard Wagner´s works. Providing with a more specific approach to this reflection, this analysis focusses on Siegfried, the densest Wagner´s Musical drama according fairy tales atmosphere in his opera omnia, and the influences and the thematical, formal and linguistical appropiations from the KHM, already studied. The article gives for granted that there are two elements used by Wagner in his musical dramas: symbols for the articul...

  2. Statistical ultrasonics: the influence of Robert F. Wagner

    Science.gov (United States)

    Insana, Michael F.

    2009-02-01

    An important ongoing question for higher education is how to successfully mentor the next generation of scientists and engineers. It has been my privilege to have been mentored by one of the best, Dr Robert F. Wagner and his colleagues at the CDRH/FDA during the mid 1980s. Bob introduced many of us in medical ultrasonics to statistical imaging techniques. These ideas continue to broadly influence studies on adaptive aperture management (beamforming, speckle suppression, compounding), tissue characterization (texture features, Rayleigh/Rician statistics, scatterer size and number density estimators), and fundamental questions about how limitations of the human eye-brain system for extracting information from textured images can motivate image processing. He adapted the classical techniques of signal detection theory to coherent imaging systems that, for the first time in ultrasonics, related common engineering metrics for image quality to task-based clinical performance. This talk summarizes my wonderfully-exciting three years with Bob as I watched him explore topics in statistical image analysis that formed a rational basis for many of the signal processing techniques used in commercial systems today. It is a story of an exciting time in medical ultrasonics, and of how a sparkling personality guided and motivated the development of junior scientists who flocked around him in admiration and amazement.

  3. Trypanosoma cruzi Infection in an Indigenous Kariña Community in Eastern Venezuela

    Directory of Open Access Journals (Sweden)

    Mariolga Berrizbeitia

    2012-01-01

    Full Text Available We investigated the seroprevalence of Trypanosoma cruzi infection in an indigenous Kariña population in eastern Venezuela. A total of 175 serum samples were collected in the community of Piñantal during February 2009. Interviews targeting socioeconomic and environmental factors associated with the T. cruzi transmission were also conducted. Samples were evaluated using trypomastigote excreted/secreted antigens (TESAs in an ELISA format. TESA-ELISA positive samples were confirmed by indirect haemagglutination (HAI (Wiener. A nonsystematic collection of vectors was also undertaken. T. cruzi seroprevalence was 7.43% according to both assays, and the mean age of infected patients was 48.61±10.40 years (range 34 to 73 years. The vector infection rate was 20.00% (2/10. T. cruzi seropositivity was associated with a history of triatomine bites, the ability to recognize the vector and poor knowledge about Chagas disease, but no associations were found with gender, house type, knowledge of how the disease is transmitted, or the presence of vectors or animals inside dwellings. To our knowledge, this is the first study of the seroprevalence of T. cruzi in an indigenous population in eastern Venezuela. All of the epidemiological variables required for the establishment of active vectorial transmission of T. cruzi were present in this community.

  4. [The etiology of leprosy and Gerhard Henrik Armauer Hansen: what does "Armauer" mean?].

    Science.gov (United States)

    Hundeiker, M

    2014-09-01

    Hansen discovered the bacteria in 1873 in unstained material and is therefore recognized as the discoverer of the leprosy pathogen. Hansen is a very common surname but in contrast Armauer is a very rare surname. Gerhard Henrik Hansen added the maiden name of his grandmother on his mother's side to his name early on. This happened not only out of family attachments but also as a physician and aspiring scientist to set himself apart from other Hansens.

  5. [Armauer Hansen (1841-1912), portrait of a Nordic pioneer].

    Science.gov (United States)

    Hansen, Willy; Freney, Jean

    2002-01-01

    Desending from a Danish family, Gerhard Henrik Armauer Hansen was born in Bergan, Norway, on 29 July, 1841. Graduated in medicine in 1866 from the University at Christiana (the former name of Oslo), he started his medical career as an assistant physician at the National Hospital of Oslo for one year, working afterwards as a medical officer for a fishing company outside the Arctic Circle. Taking not well his routine job, he soon returned to Bergen where he began his work on a disease known as leprosy at the age of 26 and as an assistant of D.C. Danielssen at the Lungegaarden Hospital. There he engaged in research and investigations on the nature of the disease. Studying the various types of leprosy (skin, nerve and visceral lesions), he was awarded, one year after beginning his work, the gold metal of the University for his first publication on the disease. While Danielssen leaned toward heredity as a dominant factor in leprosy, Hansen's conviction was that the disease must have an infectious causal agent. In about 1871, Hansen began to observe tiny little rods in tissue specimens and considered they could be the ethiologic agent of leprosy, the more he found these rods in all the infiltrated nodular lesions in his patients. Finally, he proposed on February 28, 1873, that the rods were bacilli, responsible of leprosy. Promoted to the rank of Chief of the Leprosy Service in 1875, he held his job for 37 years; Hansen's entire adult life was spent at work in leprosy. He edited the journal . Hansen was also an eminent zoologist engaged in studies involving mollusks and worms; Since 1874, he was president of the Bergen Museum of Natural History. Armauer Hansen died on February 12, 1912, and the funeral ceremonies took place in the Museum of Bergen where his ashes are still kept.

  6. Problems of millipound thrust measurement. The "Hansen Suspension"

    Energy Technology Data Exchange (ETDEWEB)

    Carta, David G.

    2014-03-31

    Considered in detail are problems which led to the need and use of the 'Hansen Suspension'. Also discussed are problems which are likely to be encountered in any low level thrust measuring system. The methods of calibration and the accuracies involved are given careful attention. With all parameters optimized and calibration techniques perfected, the system was found capable of a resolution of 10 {mu} lbs. A comparison of thrust measurements made by the 'Hansen Suspension' with measurements of a less sophisticated device leads to some surprising results.

  7. Hansen's disease with HIV: a case of immune reconstitution disease.

    Science.gov (United States)

    Chow, Dominic; Okinaka, Leila; Souza, Scott; Shikuma, Cecilia; Tice, Alan

    2009-03-01

    Immune reconstitution inflammatory syndrome (IRIS) is an acute symptomatic expression of a latent infection during the recovery of the immune system usually as a response to antiretroviral therapy (ART). Opportunistic infections can trigger IRIS. Hansen's disease is an infection caused by Mycobacterium leprae (M. leprae). There have been a limited number of case reports reporting the presentation of the co-infection of HIV and M. leprae. We report an unique case of IRIS in a patient co-infected with HIV and M. leprae presenting as an exacerbation of his Hansen's Disease where the patient's skin lesions progressed from borderline tuberculoid to lepromatous leprosy following ART administration.

  8. Ocular manifestation in treated multibacillary Hansen's disease.

    Science.gov (United States)

    Parikh, Rajul; Thomas, Saju; Muliyil, Jayaprakash; Parikh, Shefali; Thomas, Ravi

    2009-11-01

    To report the prevalence of ocular morbidity in patients with treated multibacillary Hansen's disease (HD) using modern ophthalmic diagnostic techniques in a rural community endemic for HD. Cross-sectional, observation study. All patients with multibacillary HD who had completed their multidrug therapy and who resided in 4 defined geographical areas in Vellore, Tamil Nadu, India. All participants underwent a complete eye examination that included slit-lamp examination, esthesiometry, gonioscopy, applanation tonometry, and dilated fundus examination, including a stereobiomicroscopic examination of the fundus at an ophthalmic center set up for that purpose. Glaucoma suspects underwent automated perimetry using a Humphrey Field Analyzer (Humphrey Instruments, San Leandro, CA). The prevalence of various ocular disease parameters were reported as mean value with 95% confidence interval. The difference of disease prevalence between various leprosy groups was compared using an unpaired t test. The association between eye symptoms and potentially sight-threatening complications was analyzed using the chi-square test. Three hundred eighty-six of the 446 patients with multibacillary HD residing in the defined areas were evaluated. Four patients (1.04%; 95% confidence interval [CI], 0.0%-2.0%) were bilaterally blind; 33 (8.55%; 95% CI, 5.8%-11.3%) had unilateral blindness. Mean intraocular pressure was 12 mmHg (standard deviation, 4.1 mmHg), and prevalence of glaucoma was 3.6% (95% CI, 1.8%-5.5%). Potentially sight-threatening (PST) pathologic features (corneal anesthesia, lagophthalmos, uveitis, scleritis, and advanced glaucoma) were present in 10.4% (95% CI, 7.4%-13.4%) of patients. Significant cataracts occurred 3 times more frequently in those with polar lepromatous leprosy. The odds ratio for PST pathology in the presence of patient-reported symptoms (pain, redness, inability to close eye, burning, and irritation) was 2.9 (95% CI, 1.34-6.26). Patients who have completed

  9. Guillain-Barre syndrome: A rare manifestation of Hansen's disease

    National Research Council Canada - National Science Library

    Rakshith, K; Pai, Shivanand; Mittal, Saumya; Misri, Z; Shenoy, Nisha

    2017-01-01

    ... 5 days. The weakness was distal as well as proximal. The patient also turned out to be a case of Hansen's disease. This was detected approximately 2 months before his presentation to the hospital as a result of ulceration of the foot. He was off treatment because of gastric ulcerations. There was no other significant medical history. The pati...

  10. Hansen's disease and HIV coinfection with facial nerve palsy.

    Science.gov (United States)

    Yadav, Nidhi; Kar, Sumit; Madke, Bhushan; Gangane, Nitin

    2015-01-01

    There are very few published reports of HIV leprosy co infection in India in spite of having a large burden of both leprosy and HIV. Herein we are reporting a case of co-infection of Hansen's disease and HIV with facial nerve palsy.

  11. The Trail Inventory of Julia Butler Hansen Refuge [Cycle 1

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Julia Butler Hansen Refuge for the Columbian White-Tailed Deer. Trails in...

  12. Extended Hansen solubility approach: naphthalene in individual solvents.

    Science.gov (United States)

    Martin, A; Wu, P L; Adjei, A; Beerbower, A; Prausnitz, J M

    1981-11-01

    A multiple regression method using Hansen partial solubility parameters, delta D, delta p, and delta H, was used to reproduce the solubilities of naphthalene in pure polar and nonpolar solvents and to predict its solubility in untested solvents. The method, called the extended Hansen approach, was compared with the extended Hildebrand solubility approach and the universal-functional-group-activity-coefficient (UNIFAC) method. The Hildebrand regular solution theory was also used to calculate naphthalene solubility. Naphthalene, an aromatic molecule having no side chains or functional groups, is "well-behaved', i.e., its solubility in active solvents known to interact with drug molecules is fairly regular. Because of its simplicity, naphthalene is a suitable solute with which to initiate the difficult study of solubility phenomena. The three methods tested (Hildebrand regular solution theory was introduced only for comparison of solubilities in regular solution) yielded similar results, reproducing naphthalene solubilities within approximately 30% of literature values. In some cases, however, the error was considerably greater. The UNIFAC calculation is superior in that it requires only the solute's heat of fusion, the melting point, and a knowledge of chemical structures of solute and solvent. The extended Hansen and extended Hildebrand methods need experimental solubility data on which to carry out regression analysis. The extended Hansen approach was the method of second choice because of its adaptability to solutes and solvents from various classes. Sample calculations are included to illustrate methods of predicting solubilities in untested solvents at various temperatures. The UNIFAC method was successful in this regard.

  13. A hanseníase no laboratório Hansen's disease in the laboratory

    Directory of Open Access Journals (Sweden)

    Euzenir Nunes Sarno

    2003-01-01

    Full Text Available Médica, doutora em patologia, Euzenir Sarno é estudiosa da imunopatologia da hanseníase, infecção crônica das mais antigas que constitui uma doença exclusivamente humana. Integrante de um dos ambulatórios de referência sobre a doença no Brasil, no qual são diagnosticados de 220 a 250 pacientes novos/ano, ressalta que uma das conseqüências da impossibilidade de se cultivar o Mycobacterium leprae é a permanência das mesmas questões seculares a respeito da transmissão e a suscetibilidade à doença. Há, também, muitas interrogações no terreno epidemiológico que permanecem sem resposta. Estima-se que entre as pessoas que mantêm contato com pacientes multibacilares, 90% são infectados mas apenas 8% mais ou menos ficam doentes. O índice elevado de infecção de quem convive com doentes multibacilares, sem que a doença se manifeste, indica que apenas um pequeno número de indivíduos não tem resistência ao Mycobacterium leprae. Essa é uma das questões que a imunologia não consegue responder: por que algumas pessoas têm resistência e outras não. A proporção é menor se o contato ocorrer com pacientes paucibacilares, uma forma de manifestação com poucos bacilos. A hanseníase é conhecida como uma doença dermatológica, mas a especialista destaca que a primeira lesão é anestésica: o nervo é atingido. Além dos nervos sensitivos da pele, há danos que determinam lesões motoras e deformidades irreversíveis, que levam à amputação de extremidades. O Mycobacterium leprae foi uma das primeiras bactérias patogênicas que tiveram o genoma completamente seqüenciado, em 2000. Agora é que se está começando a ter realmente condições para obter testes mais precisos. A doença não é hereditária e apenas em 1986 os serviços de saúde no Brasil passaram a se organizar para combatê-la, pois durante os vinte anos de ditadura militar o sistema foi desmantelado. Em 1991, o tratamento de um ano que inclui tr

  14. Die Musik Richard Wagners im Banat und in Rumänien. Eine Rezeptionsgeschichte

    Directory of Open Access Journals (Sweden)

    Franz Metz

    2015-12-01

    Full Text Available Richard Wagner – an ihm schieden sich die Geister schon während seines Lebens. Dies geschah nicht nur in seinen deutschen Wirkungsorten, sondern auch im Südosten Europas. Schon früh fanden seine Werke auch im Banat und in Bukarest eine weite Verbreitung und das musikliebende Publikum mischte sich damals bereits in Pro- oder Kontra-Wagner-Diskussionen ein. In einem multikulturellen Raum wie das Banat, mit jahrhundertalten multiethnischen Erfahrungen und Traditionen, stieß der Wagnerkultus zuerst auf Ablehnung, später, ab 1930, wurden seine antisemitischen Anschauungen von den faschistischen Kreisen Rumäniens demagogisch missbraucht – ähnlich wie im restlichen Europa. Doch diese besondere Seite der Richard-Wagner-Rezeption hat auch eine faszinierende Auswirkung auf das allgemeine Musikleben in Rumänien und im Banat hinterlassen.

  15. Antonín Dvořák and Richard Wagner

    Directory of Open Access Journals (Sweden)

    Gabrijelova Jarmila

    2006-01-01

    Full Text Available The essay deals with the relation of prominent Czech composer Antonín Dvořák (1841–1904 to the personality and work of Richard Wagner (1813–1883. As opposed to the common opinions linking Dvořák’s name with Wagner‘s ideological opponents and placing his ‘Wagnerian’ period in the early phase of his career only, our examination shows that Dvořák’s interest in Wagner and his music was of deep and lasting nature and was significant for him throughout the whole of his life.

  16. Redescriptions of Oratosquilla indica (Hansen) and Clorida verrucosa (Hansen), with accounts of a new genus and two new species (Crustacea, Stomatopoda)

    NARCIS (Netherlands)

    Manning, Raymond B.

    1976-01-01

    Examination of the syntypes of Oratosquilla indica (Hansen) and Clorida verrucosa (Hansen), originally described from materials collected by the “Siboga” Expedition, has revealed that each of these species is based on two distinct species. A new genus is erected for O. indica and two previously unde

  17. Imunologia da hanseníase Immunology of leprosy

    Directory of Open Access Journals (Sweden)

    Vanessa Amaral Mendonça

    2008-08-01

    Full Text Available A hanseníase é doença crônica infecciosa que se caracteriza por apresentar formas clínicas contrastantes, que são dependentes da interação do bacilo com a resposta imune do hospedeiro. O estudo dos processos imunológicos torna-se fundamental para o entendimento dos mecanismos envolvidos na apresentação e no desenvolvimento da doença. Neste artigo, é revisada a imunopatogênese da hanseníase.Leprosy is a chronic infectious disease characterized by contrasting clinical forms that are dependent on the interactions between the bacillus and the host immune response. Thus, the study of the immunological process is extremely relevant for the comprehension of the mechanisms involved in leprosy presentation and development. In this paper, the immunopathogenesis of leprosy is reviewed.

  18. Hansen's disease in association with immune reconstitution inflammatory syndrome.

    Science.gov (United States)

    George, Anju; Vidyadharan, Suja

    2016-01-01

    Immune reconstitution inflammatory syndrome is characterized by a paradoxical worsening of an existing infection or disease process, soon after initiation of highly active antiretroviral therapy. The first case of leprosy presenting as immune reconstitution inflammatory syndrome was published in 2003. Here we report a case of Hansen's disease borderline tuberculoid presenting with type 1 lepra reaction 5 months after initiation of highly active antiretroviral therapy.

  19. A note on Hansen's coefficients in satellite theory

    Science.gov (United States)

    Giacaglia, G. E. O.

    1976-01-01

    General formulas for Hansen's coefficients in satellite theory are derived along with expressions for the eccentricity functions G and H. Recurrence relations for the eccentricity functions and their derivatives are obtained which are valid for all values of the parameter p. It is noted that the recurrence relations obtained by Challe and Laclaverie (1969) as well as by Balmino (1973) do not satisfy certain parity conditions and therefore involve coefficients outside the range of usage.

  20. [Hansen's disease, social conditions, and deforestation in the Brazilian Amazon].

    Science.gov (United States)

    Silva, Diego Ricardo Xavier; Ignotti, Eliane; Souza-Santos, Reinaldo; Hacon, Sandra de Souza

    2010-04-01

    To analyze the association between social and environmental indicators and the Hansen's disease new case detection rate (HNCDR) in the Brazilian Amazon. This ecological study was based on the new cases of Hansen's disease reported to the Brazilian Disease Surveillance System SINAN in 2006. Analyses were performed considering 105 micro-regions formed by adjacent municipalities with economic and social similarities. HNCDRs per 10 000 people were calculated. Independent variables were total area deforested (km(2)) in each micro-region until 2006; proportion of people living in households with rudimentary septic tanks; proportion of people living in households with water supply from wells; and human development index (HDI) in 2000. Local empirical Bayes smoothing was applied to HNCDR. Analyses were carried out to determined correlations and differences between means (analysis of variance) for a significance level of 5%. The Kernel technique was used to investigate the geographic distribution of events of interest for all the study indicators. A positive correlation was observed between HNCDR and total deforested area (r = 0.50; P Hansen's disease new case detection rate, which reflects the magnitude of disease, is associated with social conditions and land settlement practices in the Brazilian Amazon.

  1. Closed loop identification using a modified Hansen scheme

    Science.gov (United States)

    Sekunda, A.; Niemann, H.; Kjølstad Poulsen, N.; Santos, I.

    2015-11-01

    It is often not feasible or even impossible to identify a plant in open loop. This might be because the plant contains unstable poles, or it is simply too expensive to remove the plant from its intended operation, among other possibilities. There are several methods for identifying a plant in closed loop [4], and one such method is the Hansen scheme [1]. Standard identification using Hansen scheme demands generating the identification signals indirectly. In this paper it is instead proposed to use the relationship between the Youla factorization of a plant and its stabilizing controller to directly measure the signals used for identification. A simulation example and identification of a gas bearing is given to show the method in action. Rotors supported by controllable gas bearings are open loop stable systems. However as the rotational speed is increased feedback control is necessary in order to keep the system stable. Furthermore because the dynamics of such a system depends on the rotational speed it is needed to conduct an identification while the system is part of a closed loop scheme. The authors believe the paper able to contribute towards a simpler and more direct way of identifying closed loop plants using Hansen scheme.

  2. Conflict en compassie: een hedendaagse blik op Wagner en een wagneriaanse blik op onszelf

    NARCIS (Netherlands)

    Keestra, M.; Helmers, R.; Westbroek, P.

    2014-01-01

    Richard Wagner was niet alleen een uitzonderlijke componist en auteur maar ook een activist die zijn ogen op de toekomst gericht had. Dat lijkt verbazingwekkend gezien het feit dat zijn opera’s veelal plaatsvinden in historische en zelfs mythologische tijden. Zijn activisme blijkt bijvoorbeeld uit d

  3. Extending Firth and Wagner's (1997) Ontological Perspective to L2 Classroom Praxis and Teacher Education

    Science.gov (United States)

    Lantolf, James P.; Johnson, Karen E.

    2007-01-01

    In this article, we extend Firth and Wagner's (1997) call for an ontological perspective that (re)unites the individual and the social by proposing some fundamental implications that this call has for second language (L2) classroom praxis and teacher education. We propose that the (re)unification of language and culture (re)establishes the unity…

  4. Learning the Rescorla-Wagner Model of Pavlovian Conditioning: An Interactive Simulation

    Science.gov (United States)

    Renner, Michael J.

    2004-01-01

    The Rescorla-Wagner model is one of the cornerstones of learning theory. However, many students in undergraduate courses find the model's concepts difficult to grasp, and the model is often the students' first exposure to computational models in psychology. This article describes an interactive simulation based on an Excel(r) spreadsheet program…

  5. Símbolo y forma: los hermanos Grimm en Richard Wagner

    Directory of Open Access Journals (Sweden)

    Miguel Salmerón Infante

    2015-05-01

    Full Text Available Este escrito estudia el cómo y el porqué de la presencia de los Cuentos de los Hermanos Grimm en la obra de Richard Wagner. Para dar un enfoque más concreto a esta reflexión el análisis se centra en Sigfrido, el drama musical de Wagner con más atmósfera de cuento, y las influencias y préstamos temáticos, formales y lingüísticos que le aportan los KHM. El artículo entiende que hay dos elementos que aprovecha Wagner de los Grimm para sus dramas musicales. El símbolo para su proyecto de tejido de la identidad alemana. Y la forma del cuento con sus temas y fórmulas recurrentes que el aplicó a su música y muy concretamente al Leitmotiv. Todo ello sin olvidar la muy frecuente presencia de la figura del huérfano tanto en Wagner como en los Grimm.

  6. Advective and Conductive Heat Flow Budget Across the Wagner Basin, Northern Gulf of California

    Science.gov (United States)

    Neumann, F.; Negrete-Aranda, R.; Contreras, J.; Müller, C.; Hutnak, M.; Gonzalez-Fernandez, A.; Harris, R. N.; Sclater, J. G.

    2015-12-01

    In May 2015, we conducted a cruise across the northern Gulf of California, an area of continental rift basin formation and rapid deposition of sediments. The cruise was undertaken aboard the R/V Alpha Helix; our goal was to study variation in superficial conductive heat flow, lateral changes in the shallow thermal conductivity structure, and advective transport of heat across the Wagner basin. We used a Fielax heat flow probe with 22 thermistors that can penetrate up to 6 m into the sediment cover. The resulting data set includes 53 new heat flow measurements collected along three profiles. The longest profile (42 km) contains 30 measurements spaced 1-2 km apart. The western part of the Wagner basin (hanging wall block) exhibit low to normal conductive heat flow whereas the eastern part of the basin (foot wall block) heat flow is high to very high (up to 2500 mWm-2). Two other short profiles (12 km long each) focused on resolving an extremely high heat flow anomaly up to 15 Wm-2 located near the intersection between the Wagner bounding fault system and the Cerro Prieto fault. We hypothesize that the contrasting heat flow values observed across the Wagner basin are due to horizontal water circulation through sand layers and fault pathways of high permeability. Circulation appears to be from west (recharge zone) to east (discharge zone). Additionally, our results reveal strong vertical advection of heat due to dehydration reactions and compaction of fine grained sediments.

  7. Some Words in Defense of the Psycholinguistic Approach: A Response to Firth and Wagner.

    Science.gov (United States)

    Poulisse, Nanda

    1997-01-01

    Responds to some of the arguments in Firth and Wagner's (F&W's) article appearing in this issue. Argues that whether one uses a psychological or sociological paradigm, it makes sense to follow the practice of assigning preference to experimental rather than naturalistic settings and agrees with F&W that other factors besides one's proficiency in…

  8. [The religious imaginary of Hansen's disease patients: a comparative study of former inmates of the asylums of São Paulo and current Hansen's disease patients].

    Science.gov (United States)

    Mellagi, André Gonçalves; Monteiro, Yara Nogueira

    2009-01-01

    The article analyzes the religiosity of Hansen's disease patients who lived during two distinct treatment periods of the sick: that of internment in asylums and the current practice. Ten semi-structured interviews focused on health, religion and Hansen's disease, broaching the ways the two groups faced religion. In the former inmate group, the presence of institutionalized religion was noted, which served the purposes of vigilance and isolationist therapeutics. Present day Hansen's disease patients still feel the stigmatic weight of'leprosy" in certain situations. Five questionnaires were also given to DHDS health professionals, who presented their considerations concerning the patient's religion and the treatment.

  9. Durand, Gaudet e Wagner. L'evoluzione del metodo compositivo tra XIX e XX secolo / Durand, Gaudet and Wagner. The evolution of the compositive method in modernity

    Directory of Open Access Journals (Sweden)

    Andrés Caballero Lobera

    2017-01-01

    Full Text Available Il XIX secolo fu un’epoca convulsa per quanto riguarda l’evoluzione del pensiero architettonico. In quanto apice del pensiero illuminista del secolo precedente, tale epoca si manifestò nelle forme dell’architettura storica e allo stesso tempo divenne l’immagine della modernità, stabilendo le basi di quel razionalismo, che avrebbe costruito, ai margini della storia, la sua idea di forma. Tre dei maggiori protagonisti di questo sviluppo, sia per quanto riguarda il loro lavoro di architetti, che come insegnanti, furono Jean-Nicolas-Louis Durand, Julien Guadet e Otto Wagner. / The 19th century was a time of upheaval in the development of architectonic thinking. As culmination of the enlightened thinking of the previous century it expressed itself through historical form, and as a reflection of modernity, it established the bases for a rationalist-based architecture that would construct its wish for form outside the margins of history. We highlight the teaching work of three professors and architects in the construction of that thinking: Durand, Guadet and Wagner.

  10. Hansen solubility parameters for a carbon fiber/epoxy composite

    DEFF Research Database (Denmark)

    Launay, Helene; Hansen, Charles M.; Almdal, Kristoffer

    2007-01-01

    In this study, the physical affinity between an epoxy matrix and oxidized, unsized carbon fibers has been evaluated using Hansen solubility (cohesion) parameters (HSP). A strong physical compatibility has been shown, since their respective HSP are close. The use of a glassy carbon substrate...... as a model for unsized carbon fiber has been demonstrated as appropriate for the study of interactions between the materials in composite carbon fiber-epoxy systems. The HSP of glassy carbon are similar to those of carbon fibers and epoxy matrix. (C) 2007 Elsevier Ltd. All rights reserved....

  11. Richard Wagner, Louis de Fourcaud, and a Path for French Opera in the 1880s

    Directory of Open Access Journals (Sweden)

    Marie-Hélène Benoit-Otis

    2012-05-01

    Full Text Available In a much-quoted interview with Richard Wagner conducted by the French critic Louis de Fourcaud in 1879, and published in different versions in 1880, 1884, and 1886, the composer allegedly advised the French to write operas drawing on their own legendary sources. Contemporary works such as d’Indy’s Fervaal, Chausson’s Le Roi Arthus, and Massenet’s Esclarmonde suggest that Fourcaud’s interview did indeed have a profound impact on the Wagnerian movement in France. However, a close examination of the sources reveals that his text owes much less to Wagner than scholars have previously assumed: in fact, evidence suggests that the most important part of the interview (that is, the advice to French composers was added by Fourcaud himself after Wagner’s death.

  12. Alpine meteorology: translations of classic contributions by A. Wagner, E. Ekhart, and F. Defant

    Energy Technology Data Exchange (ETDEWEB)

    Whiteman, C.D.; Dreiseitl, E. (eds.)

    1984-06-01

    The English translations of four classic research papers in Alpine meteorology, originally published in German and French in the 1930s and 1940s are presented in this report. The papers include: A. Wagner's 1938 paper entitled Theory and Observation of Periodic Mountain Winds; E. Ekhart's 1944 paper entitled Contributions to Alpine Meteorology; E. Ekhart's 1948 paper entitled On the Thermal Structure of the Mountain Atmosphere; and F. Defant's 1949 paper entitled A Theory of Slope Winds, Along with Remarks on the Theory of Mountain Winds and Valley Winds. A short introduction to these translations summarizes four recent Alpine meteorology field experients, emphasizing ongoing research that extends the research of Wagner, Ekhart, and Defant. The four experiments include the Innsbruck Slope Wind Experiment of 1978, the MESOKLIP Experiment of 1979, the DISKUS Experiment of 1980, and the ALPEX/MERKUR Experiment of 1982.

  13. Co-morbid infections in Hansen's disease patients in the United States: considerations for treatment.

    Science.gov (United States)

    Bilodeau, Madeline; Burns, Stephanie; Gawoski, John; Moschella, Samuel; Ooi, Winnie

    2013-10-01

    120 patients attending a Hansen's disease public health satellite clinic were evaluated for selected latent co-morbidities, consisting of strongyloidiasis, Chagas disease, hepatitis B, HIV, and tuberculosis, and potential exacerbation by immunosuppressive therapy. Implications for treatment of Hansen's disease are discussed.

  14. Extending the Dialogue about Science and Humanities in Counseling: A Reply to Hansen

    Science.gov (United States)

    Martin, Clayton V.; Guterman, Jeffrey T.; Kopp, David M.

    2012-01-01

    This is a reply to Hansen's (2012b) rejoinder to the authors (Guterman, Martin, & Kopp, 2012), which is a response to Hansen's (2012a) keystone article about the relationship between humanities and science in counseling. In this reply, the authors provide remaining clarifications, points of disagreement, and suggestions for future directions in…

  15. A Return to the Human in Humanism: A Response to Hansen's Humanistic Vision

    Science.gov (United States)

    Lemberger, Matthew E.

    2012-01-01

    In his extension of the humanistic vision, Hansen (2012) recommends that counseling practitioners and scholars adopt operations that are consistent with his definition of a multiple-perspective philosophy. Alternatively, the author of this article believes that Hansen has reduced the capacity of the human to interpret meaning through quantitative…

  16. The Value of Social Constructionism for the Counseling Profession: A Reply to Hansen

    Science.gov (United States)

    Rudes, James; Guterman, Jeffrey T.

    2007-01-01

    The authors reply to J. T. Hansen's (2005) call for the profession to revalue the inner subjective experiences (ISE) of clients. Hansen argued that social constructionism has influenced the decline of the counseling profession by obscuring its unique focus on ISE. The authors maintain that social constructionism is a useful framework for…

  17. On Local convergence of Hansen-Patrick's iteration methods%Hansen Patrick 迭代的局部收敛性

    Institute of Scientific and Technical Information of China (English)

    陆建芳

    2001-01-01

    The local characteristics of Hansen-Patrick's iterative methods are discussed.We introduce a function T(t),use recurrence induction method to prove the local convergence theorems of Hansen-Patrick's one parameter family of iterative methods for finding fhe zeros of an analytic function equation f(z)=0.%讨论了Hansen-Patrick迭代的局部特征关系式,引入函数T(t),利用逐步归纳技巧,证明了在α为一定条件下Hansen-Patrick迭代过程对方程f(z)=0零点的局部收敛性.

  18. The future of welfare services: How worried should we be about Wagner, Baumol and Ageing?

    OpenAIRE

    Bergh, Andreas

    2016-01-01

    Welfare services are an important part of the Nordic welfare states both financially and for welfare state redistribution. Baumol's cost disease, Wagner's law, and population ageing are often said to bring challenges for the future provision of welfare services. While none of the three poses an immediate threat against the financial sustainability of the welfare state, they have important implications for distribution and for the political support for the welfare state. The combination demogr...

  19. The Diva and the Beast: Susan Strong and the Wagnerism of Aleister Crowley

    OpenAIRE

    Allis, MJ

    2014-01-01

    Although the occultist Aleister Crowley (1875-1947) remains a fascinating and controversial figure, his connections with Richard Wagner have not been fully explored. In identifying several of Crowley’s literary works from c.1900 onwards (poetry, prose, drama) that make overt reference to Wagner’s compositions, this article suggests one possible catalyst for this burst of activity – the American soprano Susan Strong (1870-1946), to whom Crowley was briefly ‘engaged’ (according to his autohagio...

  20. Revolutionary Art – Nationalism – Anti-Semitism: The Case of Wagner

    Directory of Open Access Journals (Sweden)

    Goran Gretić

    2015-05-01

    Full Text Available The article deals with the political aspects of revolutionary art of Richard Wagner. Through reading of Wagner’s artistic-philosophical project by his most influential interpreters – Friedrich Nietzsche, Thomas Mann and Theodor Adorno – author offers intellectual history of the reception of this project. Discourse on Wagner’s revolutionary art leads to the assessment of the influence Wagner’s cultural anti-Semitism and nationalism had on European politics in 20th century.

  1. 75 FR 49516 - Lewis and Clark National Wildlife Refuge and the Julia Butler Hansen Refuge for the Columbian...

    Science.gov (United States)

    2010-08-13

    ... Fish and Wildlife Service Lewis and Clark National Wildlife Refuge and the Julia Butler Hansen Refuge... Refuge and the Julia Butler Hansen Refuge for the Columbian White-tailed Deer (refuge or collectively... Butler Hansen Final CCP/EIS'' in the subject line of the message. Mail: Willapa National Wildlife...

  2. Structure of the Wagner Basin in the Northern Gulf of California From Interpretation of Seismic Reflexion Data

    Science.gov (United States)

    Gonzalez, M.; Aguilar, C.; Martin, A.

    2007-05-01

    The northern Gulf of California straddles the transition in the style of deformation along the Pacific-North America plate boundary, from distributed deformation in the Upper Delfin and Wagner basins to localized dextral shear along the Cerro Prieto transform fault. Processing and interpretation of industry seismic data adquired by Petroleos Mexicanos (PEMEX) allow us to map the main fault structures and depocenters in the Wagner basin and to unravel the way strain is transferred northward into the Cerro Prieto fault system. Seismic data records from 0.5 to 5 TWTT. Data stacking and time-migration were performed using semblance coefficient method. Subsidence in the Wagner basin is controlled by two large N-S trending sub-parallel faults that intersect the NNW-trending Cerro Prieto transform fault. The Wagner fault bounds the eastern margin of the basin for more than 75 km. This fault dips ~50° to the west (up to 2 seconds) with distinctive reflectors displaced more than 1 km across the fault zone. The strata define a fanning pattern towards the Wagner fault. Northward the Wagner fault intersects the Cerro Prieto fault at 130° on map view and one depocenter of the Wagner basin bends to the NW adjacent to the Cerro Prieto fault zone. The eastern boundary of the modern depocenter is the Consag fault, which extends over 100 km in a N-S direction with an average dip of ~50° (up to 2s) to the east. The northern segment of the Consag fault bends 25° and intersects the Cerro Prieto fault zone at an angle of 110° on map view. The acoustic basement was not imaged in the northwest, but the stratigraphic succession increases its thickness towards the depocenter of the Wagner basin. Another important structure is El Chinero fault, which runs parallel to the Consag fault along 60 km and possibly intersects the Cerro Prieto fault to the north beneath the delta of the Colorado River. El Chinero fault dips at low-angle (~30°) to the east and has a vertical offset of about 0

  3. Podometry: a critical evaluation of its use in Hansen's disease

    Directory of Open Access Journals (Sweden)

    Júlia Maria D'Andréa Greve

    Full Text Available The aim of this paper is to evaluate the effectiveness of podometry to measure the pressure developed over the feet and the value of these findings to help in the prevention of the plantar neuropathic ulcer in patients bearing Hansen's disease. We evaluated 13 patients with impaired plantar pain and touch sensations and 17 normal patients. All the patients were submitted to static evaluation using the podometer. The system employed was the "Midcapteur" commercial podometer composed of a platform for acquisition of analogic data capable of registering the segmental pressures applied to the feet. These data are read by a 386 IBM/PC compatible computer that registers the graphic patterns obtained from the pressures developed and also calculates the modes of pressure distribution in the four quadrants of the foot. These data obtained by means of static podometry were compared to the clinical evaluation of pain and touch sensation of the feet in hansenian patients. The results demonstrate that podometery is an efficient method for evaluating the pressure in impaired feet in Hansen's disease and is a progression of neuropathic ulcer; it is sensitive in the identification of the spots of increased pressure in anesthetic and anomalous areas, asymmetries and in correlating the presence of ulcers with increased pressure.

  4. Incidence of Hansen's Disease--United States, 1994-2011.

    Science.gov (United States)

    Nolen, Leisha; Haberling, Dana; Scollard, David; Truman, Richard; Rodriguez-Lainz, Alfonso; Blum, Laura; Blaney, David

    2014-10-31

    Hansen's disease (HD), or leprosy, is caused by the bacterium Mycobacterium leprae and is reportable in many states. It is a chronic disease affecting the skin and nerves, commonly presenting as pale or reddish skin patches with diminished sensation. Without treatment, it can progress to a severely debilitating disease with nerve damage, tissue destruction, and functional loss. An important factor in limiting HD morbidity is early diagnosis and prompt initiation of therapy. Because HD is rare, clinicians in the United States are often unfamiliar with it; however, HD continues to cause morbidity in the United States. To better characterize at-risk U.S. populations, HD trends during 1994-2011 were evaluated by reviewing records from the National Hansen's Disease Program (NHDP). When the periods 1994-1996 and 2009-2011 were compared, a decline in the rate for new diagnoses from 0.52 to 0.43 per million was observed. The rate among foreign-born persons decreased from 3.66 to 2.29, whereas the rate among U.S.-born persons was 0.16 in both 1994-1996 and 2009-2011. Delayed diagnosis was more common among foreign-born persons. Clinicians throughout the United States should familiarize themselves with the signs and symptoms of HD and understand that HD can occur in the United States.

  5. Hanseníase borderline virchowiana Borderline lepromatous leprosy

    Directory of Open Access Journals (Sweden)

    Christiane Matsuo

    2010-12-01

    Full Text Available É apresentado caso de hanseníase borderline virchowiana com quatro anos de evolução e lesões cutâneas de difícil diagnóstico na rede de saúde. O exame histopatológico mostrando estruturas granulomatosas desorganizadas e múltiplos bacilos álcool-ácido resistentes foi essencial para o diagnóstico. Casos como o descrito possibilitam a contaminação dos conviventes e o surgimento de novos casos de hanseníase no futuro.It is presented a case of borderline lepromatous leprosy with 4 years of evolution and cutaneous lesions of difficult diagnosis in the National Health System. The histopathological evaluation, which was essential for the diagnosis, showed disorganized granulomatous structures and multiple alcohol -acid resistant bacilli. Cases like the one described here are responsible for the contamination of cohabitants and the appearance of new cases of leprosy.

  6. NILAI KARIES GIGI USIA 15 TAHUN DENGAN PEMERIKSA DOKTER GIGI DAN NON DOKTER GIGI DI PROVINSI KALIMANTAN BARAT TAHUN 2010

    Directory of Open Access Journals (Sweden)

    Indirawati Tjahja N

    2013-03-01

    Full Text Available ABSTRACT Background: Dental caries are usual/y caused by poor oral hygiene, resulting in the accumulation of plaque that contains a variety of bacteria. Method: This study uses diagnostic test research design. The study was conducted at the health center Kedondong, Ketapang district of West Kalimantan. Subjects numbered 30 children, consisting of men and women aged 15 years, each subject wil/ be examined by 10 dentists and 10 non-dentists. Non-dentists include nursing academy, academy of nutrition, pharmaceutical academy, academy of enviromental health and public health scholers. The research objective was to compare the results of the DMF- T (Decay Missing Fil/ing Treatment between a dentist and non-dentist. Result: The results obtained, the smal/est difference mean DMF- T with the dentist examiner was between 3.8000-3.8667, while the non-dentist examiner is 3.1333. Conclusion: The measurement of non-dentists is lower than the measurement of the dentist. Key words: dental caries, DMF- T, dentist and non-dentist, aged 15 years ABSTRAK Latar Belakang: Karies gigi umumnya disebabkan, karena kebersihan mulut yang buruk, sehingga terjadi akumulasi plak yang mengandung berbagai macam bakteri. Penelitian ini menggunakan desain penelitian uji Diagnostik. Metode: Penelitian dilakukan di Puskesmas Kedondong kabupaten Ketapang Kalimantan Barat. Subjek penelitian berjumlah 30 anak, yang terdiri dari laki-laki dan perempuan yang berusia 15 tahun, Masing-masing subjek akan diperiksa oleh 10 orang dokter gigi dan 10 orang non-dokter gigi. Non-dokter gigi meliputi Akademi Keperawatan, Akademi Gizi, Akademi Farmasi, Akademi Kesehatan Lingkungan, dan Sarjana Kesahatan Masyarakat. Tujuan penelitian adalah membandingkan hasil pemeriksaan DMF- T (Decay Missing Fil/ing Treatment antara dokter gigi dengan non-dokter gigi. Hasil: Hasil penelitian didapatkan, beda mean yang terkecil DMF- T dengan pemeriksa dokter gigi adalah diantara 3.8000-3.8667, sedang pemeriksa non

  7. Nietzsche against Wagner: artist’s levity, décadence, and asceticismNietzsche contra Wagner: veleidade de artista, décadence e ascetismo

    Directory of Open Access Journals (Sweden)

    Rodrigo C. Rabelo

    2010-09-01

    Full Text Available O artigo visa analisar a presença de Richard Wagner no contexto da crítica do velho Nietzsche ao ascetismo, nomeadamente na Terceira Dissertação de “Para a genealogia da moral” (1887. Para tanto, recorro também à idéia de gaia ciência e a elementos contidos em “O caso Wagner” (1888. O objetivo final é contribuir para um melhor entendimento não apenas da crítica ao ascetismo - que se dá desde o bojo da tarefa maior de uma revaloração de todos os valores, pautada quase sempre pela idéia de vontade de poder—, mas também, e mais especialmente, do conceito de arte e seus usos, na derradeira filosofia nietzscheana.The article aims to analyze the presence of Richard Wagner in the context of old Nietzsche’s critique of asceticism, namely in the Third Inquire of "Toward the genealogy of morals" (1887. To do so, I also apply the idea of gay science and elements from “The case of Wagner” (1888. In the end I hope to contribute not only for a better understanding of that critique —which transpires from within the bigger task of a revaluation of all values based, almost always, on the idea of will to power— but also, and more especially, of the concept of art and its uses, in the last nietzschean philosophy.

  8. Hanseníase no Brasil Leprosy in Brazil

    Directory of Open Access Journals (Sweden)

    Marcelo Grossi Araújo

    2003-06-01

    Full Text Available A hanseníase é doença infecciosa crônica causada pelo Mycobacterium leprae. A predileção pela pele e nervos periféricos confere características peculiares a esta moléstia, tornando o seu diagnóstico simples. O Brasil continua sendo o segundo país em número de casos no mundo, após a Índia. Aproximadamente 94% dos casos conhecidos nas Américas e 94% dos novos diagnosticados são notificados pelo Brasil. A doença manifesta-se em dois pólos estáveis e opostos (virchowiano e tuberculóide e dois grupos instáveis (indeterminado e dimorfo. Em outra classificação a doença é dividida em forma tuberculóide, borderline ou dimorfa que são subdivididos em dimorfa-tuberculóide, dimorfa-dimorfa e dimorfa-virchowiana, e virchowiana. A baciloscopia é o exame complementar mais útil no diagnóstico. O tratamento da hanseníase compreende: quimioterapia específica, supressão dos surtos reacionais, prevenção de incapacidades físicas, reabilitação física e psicossocial. A poliquimioterapia com rifampicina, dapsona e clofazimina revelou-se muito eficaz e a perspectiva de controle da doença no Brasil é real no curto prazo.Leprosy or Hansen's disease is a chronic infectious disease caused by the Mycobacterium leprae. The skin and nervous manifestations of the disease present a singular clinical picture that is easily recognized. After India, Brazil still is the second country with the greatest number of cases in the world. Around 94% of the known cases and 94% of the new cases reported in America, come from Brazil. The disease presents itself in two well-defined stable and opposite poles (lepromatous and tuberculoid and two unstable groups (indeterminate and dimorphic. The spectrum of presentation of the disease may also be classified as: tuberculoid tuberculoid (TT, borderline tuberculoid (BT, borderline borderline (BB, borderline lepromatous (BL and lepromatous lepromatous (LL. The finding of acid fast bacillus in tissue is the

  9. Hansen's disease (leprosy) complicated by secondary mycobacterial infection.

    Science.gov (United States)

    Scollard, David M; Stryjewska, Barbara M; Prestigiacomo, John F; Gillis, Thomas P; Waguespack-Labiche, Jennifer

    2011-03-01

    A patient with Hansen's disease received corticosteroids for a type 1 leprosy reaction and subsequently developed a new cutaneous lesion at the original biopsy site from which Mycobacterium fortuitum was cultured. A review of the literature found only two other cases of coinfection with atypical mycobacteria and Mycobacterium leprae, although there are many reports of pulmonary tuberculosis in patients with leprosy. This case highlights the diagnostic difficulties encountered when a patient has two different mycobacterial infections of the skin. The published experience emphasizes that such coinfection is remarkably uncommon in leprosy, despite the frequent use of high doses of corticosteroids for leprosy reactions. Copyright © 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  10. Tinea Barbae: In Released from Treatment (RFT) Hansen's Disease Patient.

    Science.gov (United States)

    Thangaraju, Pugazhenthan; Giri, Vc; Singh, Hosanna; Kumar, Vinod; Ali, Showkath

    2014-07-01

    Hansen Disease (leprosy) is a chronic inflammatory infectious disease that primarily targets skin, nerves and other internal organs (testis, liver etc.) caused by the acid fast intracellular bacilli, Mycobacterium leprae. Clinical presentation occurs with a wide spectrum including hypo pigmented anaesthetic patches, raised erythematous plaques and nodules and thickened peripheral nerves showing tenderness. The most important complication is the disability and deformity. The diagnosis of leprosy is frequently delayed because of its similarity with other more common skin conditions prevailing in some non endemic areas. We present a rare case report of tinea barbae in an old treated case of leprosy. This case is one of the rarest fungal infection in leprosy patient searched in PUBMED as there were other more tinea infection involving various sites in body which sometimes misdiagnosed as leprosy.

  11. Hypnotherapy: A Useful Adjunctive Therapeutic Modality in Hansen's Disease.

    Science.gov (United States)

    Abdul Latheef, En; Riyaz, Najeeba

    2014-03-01

    Hypnotherapy is a useful adjunctive psychotherapeutic procedure used in various conditions such as pain disorders, atopic dermatitis, and alopecia areata. However, it is less utilized in the field of dermatology. Only limited data exist on its role in the management of various skin diseases. There is dearth of literature on the role of hypnotherapy in Hansen's disease (HD). We report two cases of HD, one with very resistant neuralgia and the other with recurrent erythema nodosum leprosum (ENL). Both the patients were assessed using hospital anxiety and depression scale, dermatology life quality index and the neuralgia was assessed using the visual analog scale. Three sessions of hypnotherapy were given to both the patients. There was dramatic improvement in the incidence of ENL and neuralgia and we could rapidly reduce the dose of drugs used for both conditions.

  12. 詹姆斯·汉森%James Hansen

    Institute of Scientific and Technical Information of China (English)

    何勖

    2010-01-01

    @@ 詹姆斯·汉森(James Hansen ),美国气候科学家.1941年3月出生于美国艾奥瓦州.1967年在爱荷华大学获得物理学博士学位,目前为哥伦比亚大学兼职教授.1981年起汉森担任美国航天局戈达德航天研究所所长.早在1988年.汉森就在美国国会听证会上向议员们警示燃烧化石燃料等人类活动可能导致的全球变暖风险.

  13. Role of Hansen solubility parameters in solid phase extraction.

    Science.gov (United States)

    Bielicka-Daszkiewicz, K; Voelkel, A; Pietrzyńska, M; Héberger, K

    2010-08-27

    The sorbent-eluent systems combined from eight polymeric sorbents and seven solvents as eluents were used for the extraction of phenol and its oxidation products from water samples. The individual interactions between sorbents, eluents and analytes were characterized by Hansen solubility parameters. Principal components analysis (PCA) was used for revealing the dominant interactions (dispersive, polar, and hydrogen bonding type) in sorbent-analyte-eluent systems. The importance of solubility parameters was also determined by a novel procedure based on sum of ranking differences (SRD). Although PCA and ranking by SRD are based on different principles and calculations, they have provided very similar results. The recovery in a given system has been predicted from the magnitudes of mutual interactions (sorbent-analyte, sorbent-eluent, analyte-eluent) by multiple linear regression.

  14. Hansen solubility parameters for polyethylene glycols by inverse gas chromatography.

    Science.gov (United States)

    Adamska, Katarzyna; Voelkel, Adam

    2006-11-03

    Inverse gas chromatography (IGC) has been applied to determine solubility parameter and its components for nonionic surfactants--polyethylene glycols (PEG) of different molecular weight. Flory-Huggins interaction parameter (chi) and solubility parameter (delta(2)) were calculated according to DiPaola-Baranyi and Guillet method from experimentally collected retention data for the series of carefully selected test solutes. The Hansen's three-dimensional solubility parameters concept was applied to determine components (delta(d), delta(p), delta(h)) of corrected solubility parameter (delta(T)). The molecular weight and temperature of measurement influence the solubility parameter data, estimated from the slope, intercept and total solubility parameter. The solubility parameters calculated from the intercept are lower than those calculated from the slope. Temperature and structural dependences of the entopic factor (chi(S)) are presented and discussed.

  15. Determination of Hansen solubility parameters of fatty ethyl esters

    OpenAIRE

    Matheus Maciel Batista

    2010-01-01

    Resumo: Os parâmetros de solubilidade tridimensional definidos por Hansen são baseados em forças de dispersão entre as unidades estruturais, interações entre os grupos polares e de ligação de hidrogênio. Para compostos, tais como ésteres graxos que apresentam longas cadeias carbônicas, essa abordagem foi utilizada para obter as três coordenadas de parâmetros de solubilidade em termos de: uma parte de dispersão, uma parte polar e uma parte de ligação de hidrogênio. Está presente neste trabalho...

  16. Extended Hansen approach: calculating partial solubility parameters of solid solutes.

    Science.gov (United States)

    Wu, P L; Beerbower, A; Martin, A

    1982-11-01

    A multiple linear regression method, known as the extended Hansen solubility approach, was used to estimate the partial solubility parameters, delta d, delta p, and delta h for crystalline solutes. The method is useful, since organic compounds may decompose near their melting points, and it is not possible, to determine solubility parameters for these solid compounds by the methods used for liquid solvents. The method gives good partial and total solubility parameters for naphthalene; with related compounds, less satisfactory results were obtained. At least three conditions, pertaining to the regression equation and the solvent systems, must be met in order to obtain reasonable solute solubility parameters. In addition to providing partial solubility parameters, the regression equations afford a calculation of solute solubility in both polar and nonpolar solvents.

  17. Surface state of carbon nanotubes and Hansen solubility parameters.

    Science.gov (United States)

    Detriche, S; Nagy, J B; Mekhalif, Z; Delhalle, J

    2009-10-01

    Carbon nanotubes (CNTs) are often described as insoluble or poorly soluble in organic solvents. In a recent study, we have reported that nonfunctionalized CNTs can be solubilized in suitably chosen organic solvents. Furthermore, their solubility could be understood in terms of the Hansen Solubility Parameters (HSPs). The present work addresses further the question of the CNTs solubility by considering a larger range of solvents. A second part is devoted to the application of the HSPs to two types of functionalized CNTs: oxidized and silanized. These results stress the critical role played by the surface state of the CNTs, on the one hand, and the interest in using the HSPs to guide solubility investigations, on the other hand.

  18. Gallium scintigraphy in Hansen's disease

    Energy Technology Data Exchange (ETDEWEB)

    Braga, F.J.H.N. (Hopital Henri-Mondor, 75 - Paris (France). Service de Biophysique de Medecine Nucleaire Sao Paulo Univ., SP (Brazil). Centro de Medicina Nuclear); Araejo, E.B.; Camargo, E.E. (Sao Paulo Univ., SP (Brazil). Centro de Medicina Nuclear); Tedesco-Marchesi, L.C.M.; Rivitti, M.C.M. (Sao Paulo Univ., SP (Brazil). Servicio de Dermatologia); Bouladour, H.; Galle, P. (Hopital Henri-Mondor, 75 - Paris (France). Service de Biophysique de Medecine Nucleaire)

    1991-11-01

    Gallium 67 imaging was used in 12 patients with documented Hansen's disease undergoing treatment or not in an attempt to determine the pattern of the disease. Diagnosis was confirmed by histopathology in all patients. The Mitsuda reaction was seen in all patients. Specific nuclear studies were performed when needed to evaluate particular organs better. Gallium 67 images show homogeneous, diffuse and moderate accumulation over the entire skin surface (except for the face) of untreated patients with multibacillary disease. The face skin in these cases presented homogeneous, diffuse but very marked uptake of gallium. Internal organ involvement was variable. There was a very good correlation among clinical, scintigraphical, immunological and histopathological data. The pattern of the body skin ('skin outlining') and face skin ('beard distribution') may be distinct for untreated patients with multibacillary leprosy. (orig.).

  19. Hypertrophic Neuropathy Secondary to Hansen's Disease. A Case Report

    Directory of Open Access Journals (Sweden)

    María Octavina Rodríguez Roque

    2016-08-01

    Full Text Available We present the case 49-year-old unmarried woman treated at the hospital of Cienfuegos. The patient complained of weakness in the lower limbs and "numbness" (paresthesia of all four extremities, which improved slightly after treatment. A year later, the muscle weakness and paresthesia worsened, particularly in the upper limbs. She also developed hypopigmented skin lesions on the chest and abdomen. The investigation was initiated due to suspicion of hypertrophic polyneuropathy. A biopsy of the hypochromic lesions was performed, which led to the conclusion that the patient suffered from a hypertrophic polyneuropathy secondary to tuberculoid Hansen's disease. We decided to present this case since a neuropathy is usually slow, insidious and has a long course in these patients; however, leprosy reactions can lead to acute nerve damage, resulting in disabilities and deformities. Consequently, it is important to act quickly in order to avoid them.

  20. Chronicles of Gerhard-Henrik Armauer Hansen's Life and Work.

    Science.gov (United States)

    Ghosh, Sangita; Chaudhuri, Soumik

    2015-01-01

    Gerhard-Henrik Armauer Hansen, a Norwegian scientist, discovered Mycobacterium leprae as the causative organism for leprosy, defying the hereditary affliction theory of the disease. He was born in Bergen, Norway in 1841 in a Danish family. After acquiring his medical degree in 1866 from the University of Oslo, he joined as an assistant physician in a leprosy hospital in Bergen. In 1873, he published his report claiming leprosy to be an infectious disease with a description of the infectious material in leprous tissue. His conviction of belief and an unstinted devotion to a lifetime of scientific research changed the way leprosy was approached as a disease. It was the fruit of his untiring work that the amended act of 1885 was passed, which resulted in steady decline in leprosy burden in Norway. In February 1912 he breathed his last, leaving behind an inspirational story of a brave heart scientist who fought all odds to unveil the truth for the benefit of mankind.

  1. Indigenous Cases of Leprosy (Hansen's Disease) in Southern Mississippi.

    Science.gov (United States)

    Marcos, Luis A; Dobbs, Thomas; Walker, Sue; Waller, William; Stryjewska, Barbara M

    2015-07-01

    Hansen's disease or leprosy is a chronic infection of the skin and peripheral nerves caused by Mycobacterium leprae. In the U.S., leprosy is mainly reported in immigrants, but indigenous leprosy cases have been also reported in this country, especially in semitropical southern states (i.e., Texas, Louisiana). The objective of this series of cases is to describe indigenous leprosy cases reported in southern Mississippi (MS) during the period 2012-2014. Information was collected from medical records at Hattiesburg Clinic and the MS Department of Health. Four cases were reported during the period of study (3 Caucasian males, 1 African-American woman). Non of visited endemic leprosy country. The age ranged from 60 to 83 years (median: 75.5 years). Of the four cases, three presented with a slowly progressive erythematous rash disseminated mainly on the thorax and abdomen, with a lesser degree on the extremities. The time between onset of rash until the diagnosis ranged from 5 to 16 months (median: 7 months). Only one case had direct contact with armadillos (blood exposure). Non of these patients had a history of immunosuppression. The most common symptoms were neuropathic pain (n=2), generalized pruritus (n=2) and loss of sensation in extremities (n=2). One case had severe peripheral neuropathy with muscle weakness, atrophy in left arm, and wasting on left hand. Skin biopsies showed diffuse granulomatous infiltrate with foamy histiocytes along with acid fast bacilli by Fite stain. By Ridley-Jopling classification system, three cases were diagnosis as lepromatous leprosy, and one, borderline lepromatous. Treatment included clofazimine, dapsone and rifampin that was offered free of charge by the National Hansen's Diseases Program, Baton Rouge, L.A. One patient did not tolerate therapy. In conclusion, a slowly progressive disseminated erythematous skin rash on the trunk should raise suspicion for leprosy in the elderly population in south MS.

  2. The Effect of Richard Wagner's Music and Beliefs on Hitler's Ideology

    Directory of Open Access Journals (Sweden)

    Carolyn S. Ticker

    2016-09-01

    Full Text Available The Holocaust will always be remembered as one of the most horrific and evil events in all of history. One question that has been so pervasive in regards to this historical event is the question of why. Why exactly did Hitler massacre the Jewish people? Why did he come to the conclusion that the Jews were somehow lesser than him, and that it was okay to kill them? What and who were his influences and how did they help form Hitler’s opinions leading up to the Holocaust? Although more than one situation or person influenced Hitler, I believe that one man in particular really helped contribute to Hitler’s ideas, especially about the Jewish people. This man is the famous musician Richard Wagner. While musicologists admit that Wagner was a musical genius, one aspect of his career that is hard to ignore is his strong antisemitism. In addition to speaking about his hatred for the Jews, he also wrote about it in his music, making it hard to glance over. Hitler had been close to the Wagner family, and had an obsessive, cult-like infatuation with Wagner’s music beginning in his childhood. This infatuation with Wagner’s music and his closeness to his later family helped facilitate and solidify his negative views about the Jewish people. In this paper I will explore the antisemitism that is within Wagner’s music and writing, and then I will discuss how Wagner’s antisemitism helped inform, influence, and shape Hitler’s ideas, indirectly assisting in the propagation of the Holocaust.

  3. Tectonoestratigraphic and Thermal Models of the Tiburon and Wagner Basins, northern Gulf of California Rift System

    Science.gov (United States)

    Contreras, J.; Ramirez Zerpa, N. A.; Negrete-Aranda, R.

    2014-12-01

    The northern Gulf of California Rift System consist sofa series faults that accommodate both normal and strike-slip motion. The faults formed a series of half-greens filled with more than 7 km of siliciclastic suc­cessions. Here, we present tectonostratigraphic and heat flow models for the Tiburón basin, in the southern part of the system, and the Wag­ner basin in the north. The models are constrained by two-dimensional seis­mic lines and by two deep boreholes drilled by PEMEX­-PEP. Analysis of the seismic lines and models' results show that: (i) subsidence of the basins is controlled by high-angle normal faults and by flow of the lower crust, (ii) basins share a common history, and (iii) there are significant differences in the way brittle strain was partitioned in the basins, a feature frequently observed in rift basins. On one hand, the bounding faults of the Tiburón basin have a nested geometry and became active following a west-to-east sequence of activation. The Tiburon half-graben was formed by two pulses of fault activity. One took place during the protogulf extensional phase in the Miocene and the other during the opening of Gulf of California in the Pleistocene. On the other hand, the Wagner basin is the result of two fault generations. During the late-to middle Miocene, the west-dipping Cerro Prieto and San Felipe faults formed a domino array. Then, during the Pleistocene the Consag and Wagner faults dissected the hanging-wall of the Cerro Prieto fault forming the modern Wagner basin. Thermal modeling of the deep borehole temperatures suggests that the heat flow in these basins in the order of 110 mW/m2 which is in agreement with superficial heat flow measurements in the northern Gulf of California Rift System.

  4. The use of the Wagner function to describe poled-order relaxation processes in electrooptic polymers

    Science.gov (United States)

    Verbiest, T.; Burland, D. M.

    1995-04-01

    The Wagner (lognormal) time decay function is used to describe decay of the second harmonic signal due to electric field poled-order relaxation in the guest—host polymer system 20 wt% lophine 1 in Ultem ®. This function can be related to a Gaussian distribution of Arrhenius activation energies. From the temperature dependence of the relaxation process one can determine the average value for the activation energy. In the present case a value of 40 kcal/mol is found consistent with experimental values obtained for a variety of other thermally activated processes in polymers.

  5. Leptopsyllines from Madagascar (Insecta: Siphonaptera: Ceratophyllidae: description of five new species of Paractenopsyllus Wagner, 1938

    Directory of Open Access Journals (Sweden)

    Duchemin J.B.

    2004-03-01

    Full Text Available Five new species of the malagasy endemic genus Paractenopsyllus Wagner, 1938, are described. Paractenopsyllus rouxi, P. ratovonjatoi, P. duplantieri, P. juliamarinus and P. gemelli have been collected on endemic small mammals and the black rat. Biotopes are mid-elevation rain-forests of the central highlands or the northern mountains of Madagascar. Morphological affinities between these new species and those already known provide taxonomic links within the genus. Differences in the spatial and altitudinal distributions and host ranges allow discussion of the potential factors important in the species distribution of this genus.

  6. Uma encruzilhada estético-musical: “Música do futuro” de Richard Wagner

    Directory of Open Access Journals (Sweden)

    Marcos Mesquita

    2015-06-01

    Full Text Available O ensaio “Música do futuro” de Richard Wagner foi escrito em um momento crítico na vida do compositor. Ele procurava se afastar de conceitos divulgados por ele em textos anteriores e percebia claramente a distância entre seus ideais teóricos da década de 1840 sobre a obra de arte total (Gesamtkunstwerk e sua prática composicional da década de 1850. O texto aqui apresentado investiga as contradições entre reflexão e prática wagnerianas durante o período mencionado.

  7. Panorama sobre a hanseníase: quadro atual e perspectivas A panorama of Hansen's disease: present status and perspectives

    Directory of Open Access Journals (Sweden)

    Tadiana Alves Moreira

    2003-01-01

    Full Text Available A entrevistada fala sobre a endemia no Brasil, atualmente com 4.4 casos por dez mil habitantes, sendo o segundo país em número de doentes. Ao discorrer sobre o engajamento do Brasil no programa lançado pela Organização Mundial de Saúde, Tadiana explica que o objetivo da OMS é eliminar a hanseníase até 2005. No entanto, ela diz que a meta brasileira é, neste prazo, reduzir a incidência da doença a até menos de um caso por dez mil pessoas. Em nosso país, a estrutura e organização de tal programa, que engloba desde a formação e especialização de profissionais para garantir o diagnóstico precoce, ao acompanhamento do paciente durante o tratamento, é realizado pelo Sistema Único de Saúde (SUS, implantado em todos os estados da federação. O tratamento poliquimioterápico dura, em média, um ano, se for seguido à risca. Em muitos casos, a doença volta a se manifestar posteriormente. Ela comenta as diferenças de incidência da hanseníase, dependendo da região: já foi eliminada em dois dos três estados do Sul do país, ao passo que em estados do Norte e Centro-Oeste atinge índices hiperendêmicos. Trabalhando em estreita articulação com as associações de pacientes e ex-pacientes, inicialmente como enfermeira e, depois, na implantação das políticas de atenção ao hanseniano, Tadiana Alves Moreira fala sobre a importância do diagnóstico precoce visando evitar seqüelas físicas que a doença provoca quando alcança estágios avançados, e assim, reduzir o estigma que recai sobre os seus portadores.The interviewee speaks about the endemic disease, which at present contaminates 4.4 out of ten thousand inhabitants in Brazil, the country with the second highest number of patients. When Tadiana speaks about the Brazilian participation in the program launched by the World Health Organization, she explains that WHO's objective is to extinguish Hansen's disease on the planet until 2005. However, she says that Brazilian

  8. Julia Butler Hansen NWR: Initial Survey Instructions for Climate Change: Ground Water Level Monitoring

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Julia Butler Hansen Refuge for Columbian White-tailed Deer (JBH) manages over 5,600 acres of pastures, forested tidal swamps, brushy woodlots, marshes, and...

  9. Truth and opinion in climate change discourse: the Gore-Hansen disagreement.

    Science.gov (United States)

    Russill, Chris

    2011-11-01

    In this paper, I discuss the "inconvenient truth" strategy of Al Gore. I argue that Gore's notion of truth upholds a conception of science and policy that narrows our understanding of climate change discourse. In one notable exchange, Gore and NASA scientist, James Hansen, disagreed about whether scientific statements based on Hansen's computer simulations were truth or opinion. This exchange is featured in An Inconvenient Truth, yet the disagreement is edited from the film and presented simply as an instance of Hansen speaking "inconvenient truth". In this article, I compare the filmic representation of Hansen's testimony with the congressional record. I place their exchange in a broader historical perspective on climate change disputation in order to discuss the implications of Gore's perspective on truth.

  10. Julia Butler Hansen NWR: Initial Survey Instructions for Nocturnal Owl Surveys

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Nocturnal owl surveys are part of a larger effort on the Julia Butler Hansen Refuge (JBH) to track long-term changes in wildlife occurrence. Six owl species are on...

  11. Julia Butler Hansen NWR: Initial Survey Instructions for Multispecies Monitoring Survey

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Julia Butler Hansen Refuge for the Columbian White-tailed Deer (JBH) is a varied and dynamic system, much of which is still changing from the effects of levee...

  12. [Activity of daily living and life quality of patients with Hansen's disease in Taiwan].

    Science.gov (United States)

    Wu, Li-Ling; Cheng, Shun-Ping; Lee, Nie-Sue; Chen, I-Ju

    2010-10-01

    Hansen's Disease incidence in Taiwan has declined to the goal set by the World Health Organization. However, this population does not receive adequate attention due to the stigma attached to the disease. The purpose of this study was to investigate the demographic characteristics, activities of daily living, and quality of life of patients with Hansen's Disease in Taiwan. A cross-sectional design was used. A structured questionnaire that incorporated a personal data survey form, basic activity of daily living (BADL) form, instrument ability of daily activity of living (IADL) form and quality of life (QOL) survey was used to collect data. Patients with Hansen's Disease in Taiwan who lived in the institution, rural villages, and communities were invited to participate. Four hundred and ninety-seven participants with an average age of 71.93 (± 12.8) years participated in this study. Institutionalized participants (76.97 ± 7.41) were older than those in the other two groups. Participants were found to have in general more than one chronic disease (2.05 ± 1.33), with more chronic diseases found amongst institutionalized subjects (2.70 ± 1.23). Activities of daily living scores were generally higher for urban community dwellers than those who were institutionalized. Relatively low BADL scores for personal hygiene, bathing, walking and climbing stairs were noted, as were poor IADL scores for cooking, shopping, washing clothes and riding public transportation. Results found that activities of daily living declined with participant age (p Hansen's Disease patients with age. In order to promote quality of life among patients with Hansen's Disease, several suggestions for health policy with regard to Hansen's Disease patients are raised in this paper, including helping maintain daily living activity functions in Hansen's Disease patients, hiring more assistants and nurses to help Hansen's Disease patients maintain daily living activities and personal hygiene, and

  13. Combination of Hansen Robotic system with cryocatheter in a challenging parahisian accessory pathway ablation

    Directory of Open Access Journals (Sweden)

    Moisés Rodríguez-Mañero

    2015-11-01

    Full Text Available A perceived distinctive feature of cryoablation is the stability (cryoadherence of the catheter tip during cold temperatures at the desired location, even during tachycardia. We report the case report of a young patient with a parahisian accessory pathway where stability of the ablation catheter was not achieved despite using the cryocatheter with a steerable sheath. Ultimately, stability at the desired location was achieved robotically by means of Hansen system (Hansen Medical, Mountain View, CA, USA.

  14. Study on Absorption of Controlled/Sustained- Release Dosage Forms Evaluated Properly by Wagner-Nelson Method%正确使用Wagner-Nelson法评价缓释、控释制剂吸收度

    Institute of Scientific and Technical Information of China (English)

    张继稳; 李川

    2007-01-01

    @@ Wagner-Nelson法是Wagner与Nelson建立的用于评价单室模型药物吸收动力学的经典方法[1].该法较简便,且既不要求以静脉给药做参比,也不需要对吸收的机制与动力学模式进行限制,随着以缓释、控释制剂为主的给药系统的普及,Wagner-Nelson法得到了广泛应用[2].Wagner-Nelson法的应用如此之广,以致于人们可能会想当然地使用该法,而现有的常规药物动力学软件,如3P97,TopFit(R)和Kinetica(R)等,尚没有直接给出方便的评价缓释制剂吸收度的软件,导致在采用该法评价缓释、控释制剂时容易产生误用,即在形式上符合Wagner-Nelson法,而在具体参数的数值确定上有错误.作为官方接受的评价缓释、控释制剂吸收动力学的标准方法之一,Wagner-Nelson法用于评价该类制剂的体内吸收度,并据此评价缓释、控释制剂体内吸收和体外释放的相关性[3-5],不当使用Wagner-Nelson法得出的体内外相关性结论容易产生误导.

  15. Molecular orbital studies on the Wagner-Meerwein migration in some acyclic pinacol-pinacolone rearrangements

    Indian Academy of Sciences (India)

    Zodinpuia Pachuau; R H Duncan Lyngdoh

    2004-03-01

    The semi-empirical PM3 SCF-MO method is used to investigate the Wagner-Meerwein migration of various groups during the pinacol-pinacolone rearrangement of some acyclic systems. Pinacol first protonates and dehydrates to form a carbocation that undergoes a 1,2-migration to form a protonated ketone, which then deprotonates to yield the pinacolone product. We study the Wagner-Meerwein migration of hydride, methyl, ethyl, isopropyl, t-butyl, phenyl and heterocylic 2-, 3- and 4-pyridyl groups in various acyclic 1,2-diol (pinacol) systems as they rearrange to pinacolones. This 1,2-migration involves a three-centred moiety in the cationic transition state. The migratory aptitude predicted here follows the order: hydride -butyl > isopropyl > ethyl > methyl > phenyl, which accords well with available experimental data and/or chemical intuition, reflecting also on the ability of the group involved to carry positive charge in the transition state. The structure of the migrating group (whether aliphatic or aromatic) within the transition state also supports the stabilising role of delocalisation of positive charge for reaction feasibility. Geometrical and thermodynamic considerations coincide in assigning the following order to relative ``earliness” of the transition state along the reaction pathway: -butyl > isopropyl > phenyl > methyl > 2-pyridyl > 4-pyridyl.

  16. Long-term results of femoral revision with the Wagner Self-Locking stem.

    Science.gov (United States)

    Regis, Dario; Sandri, Andrea; Bonetti, Ingrid

    2013-09-01

    Femoral revision total hip arthroplasty may be a complex procedure due to extensive periprosthetic bone loss. Fluted, tapered stems provide secure axial and rotational stability in the distal femur. We retrospectively evaluated the long-term outcome of the cementless Wagner Self-Locking prosthesis (Sulzer Orthopedics Ltd, Winterthur, Switzerland). From 1992 to 1998, 68 consecutive femoral revisions were performed in 66 patients using the Wagner tapered stem. Twenty-five patients deceased for unrelated causes without additional surgery. The studied group consisted of 41 hips in 41 patients, 12 males and 29 females, aged from 29 to 80 years (mean 61 years). Thirty-five hips (85.4%) included severe deficiency of bone stock. A transfemoral approach was carried out in 32 cases (78%). Bone grafting was never supplemented. Average follow-up was 13.9 years (range 10.4 to 15.8 years). Clinical evaluation was performed using Harris Hip Score (HHS). Osseointegration of the stem and progression of periprosthetic bone remodelling were assessed radiographically. Five stems required rerevision because of deep infection (2), progressive subsidence (2) complicated by hip instability and head-neck disassembly, and old dislocation following acetabular component failure (1). Four hips (9.7%) dislocated, and 8 stems (19.5%) subsided significantly. Average HHS improved from 33 points preoperatively to 75 points at the latest follow-up examination (p risk complications (dislocation, subsidence) should be minimized by the development of modular stems.

  17. Active surveillance of Hansen's Disease (leprosy): importance for case finding among extra-domiciliary contacts.

    Science.gov (United States)

    Moura, Maria L N; Dupnik, Kathryn M; Sampaio, Gabriel A A; Nóbrega, Priscilla F C; Jeronimo, Ana K; do Nascimento-Filho, Jose M; Miranda Dantas, Roberta L; Queiroz, Jose W; Barbosa, James D; Dias, Gutemberg; Jeronimo, Selma M B; Souza, Marcia C F; Nobre, Maurício L

    2013-01-01

    Hansen's disease (leprosy) remains an important health problem in Brazil, where 34,894 new cases were diagnosed in 2010, corresponding to 15.3% of the world's new cases detected in that year. The purpose of this study was to use home visits as a tool for surveillance of Hansen's disease in a hyperendemic area in Brazil. A total of 258 residences were visited with 719 individuals examined. Of these, 82 individuals had had a previous history of Hansen's disease, 209 were their household contacts and 428 lived in neighboring residences. Fifteen new Hansen's disease cases were confirmed, yielding a detection rate of 2.0% of people examined. There was no difference in the detection rate between household and neighbor contacts (p = 0.615). The two groups had the same background in relation to education (p = 0.510), household income (p = 0.582), and the number of people living in the residence (p = 0.188). Spatial analysis showed clustering of newly diagnosed cases and association with residential coordinates of previously diagnosed multibacillary cases. Active case finding is an important tool for Hansen's disease control in hyperendemic areas, enabling earlier diagnosis, treatment, decrease in disability from Hansen's disease and potentially less spread of Mycobacterium leprae.

  18. Active surveillance of Hansen's Disease (leprosy: importance for case finding among extra-domiciliary contacts.

    Directory of Open Access Journals (Sweden)

    Maria L N Moura

    Full Text Available Hansen's disease (leprosy remains an important health problem in Brazil, where 34,894 new cases were diagnosed in 2010, corresponding to 15.3% of the world's new cases detected in that year. The purpose of this study was to use home visits as a tool for surveillance of Hansen's disease in a hyperendemic area in Brazil. A total of 258 residences were visited with 719 individuals examined. Of these, 82 individuals had had a previous history of Hansen's disease, 209 were their household contacts and 428 lived in neighboring residences. Fifteen new Hansen's disease cases were confirmed, yielding a detection rate of 2.0% of people examined. There was no difference in the detection rate between household and neighbor contacts (p = 0.615. The two groups had the same background in relation to education (p = 0.510, household income (p = 0.582, and the number of people living in the residence (p = 0.188. Spatial analysis showed clustering of newly diagnosed cases and association with residential coordinates of previously diagnosed multibacillary cases. Active case finding is an important tool for Hansen's disease control in hyperendemic areas, enabling earlier diagnosis, treatment, decrease in disability from Hansen's disease and potentially less spread of Mycobacterium leprae.

  19. 正确使用Wagner-Nelson法评价缓释、控释制剂吸收度

    Institute of Scientific and Technical Information of China (English)

    张继稳; 李川

    2007-01-01

    Wagner-Nelson法是Wagner与Nelson建立的用于评价单室模型药物吸收动力学的经典方法[1].该法较简便,且既不要求以静脉给药做参比,也不需要对吸收的机制与动力学模式进行限制,随着以缓释、控释制剂为主的给药系统的普及,Wagner-Nelson法得到了广泛应用[2].Wagner-Nelson法的应用如此之广,以致于人们可能会想当然地使用该法,而现有的常规药物动力学软件,如3P97,TopFit(R)和Kinetica(R)等,尚没有直接给出方便的评价缓释制剂吸收度的软件,导致在采用该法评价缓释、控释制剂时容易产生误用,即在形式上符合Wagner-Nelson法,而在具体参数的数值确定上有错误.作为官方接受的评价缓释、控释制剂吸收动力学的标准方法之一,Wagner-Nelson法用于评价该类制剂的体内吸收度,并据此评价缓释、控释制剂体内吸收和体外释放的相关性[3-5],不当使用Wagner-Nelson法得出的体内外相关性结论容易产生误导.……

  20. Chronicles of Gerhard-Henrik Armauer Hansen's Life and Work

    Science.gov (United States)

    Ghosh, Sangita; Chaudhuri, Soumik

    2015-01-01

    Gerhard-Henrik Armauer Hansen, a Norwegian scientist, discovered Mycobacterium leprae as the causative organism for leprosy, defying the hereditary affliction theory of the disease. He was born in Bergen, Norway in 1841 in a Danish family. After acquiring his medical degree in 1866 from the University of Oslo, he joined as an assistant physician in a leprosy hospital in Bergen. In 1873, he published his report claiming leprosy to be an infectious disease with a description of the infectious material in leprous tissue. His conviction of belief and an unstinted devotion to a lifetime of scientific research changed the way leprosy was approached as a disease. It was the fruit of his untiring work that the amended act of 1885 was passed, which resulted in steady decline in leprosy burden in Norway. In February 1912 he breathed his last, leaving behind an inspirational story of a brave heart scientist who fought all odds to unveil the truth for the benefit of mankind. PMID:26120145

  1. Repullic OF FRITZ HANSEN 北欧传奇

    Institute of Scientific and Technical Information of China (English)

    张思懿

    2016-01-01

    Republic of Fritz Hansen,北欧历史最悠久、网罗最多北欧建筑设计大师的家居设计品牌。纵观它的历史,俨然一出精彩的戏剧——经营者是杰出的导演,带领品牌进行着顺应时代的发展,宛如戏剧,幕起幕落渐入佳境;设计师则是这部戏中的灵魂演员,他们划时代的作品,变成了这出戏剧中的一个个经典的"形象",耐人咀嚼,历久弥新。戏剧开场Republic of Fritz Hansen这个名字,蕴合着长达138年悠久历史的专业传承。故事的起源,耍追溯到1872年。1872年,时年25岁的橱柜工匠Fritz Hansen离开了位于丹麦Nakskov的家乡,

  2. Hansen solubility parameter as a tool to predict cocrystal formation.

    Science.gov (United States)

    Mohammad, Mohammad Amin; Alhalaweh, Amjad; Velaga, Sitaram P

    2011-04-04

    The objective of this study was to investigate whether the miscibility of a drug and coformer, as predicted by Hansen solubility parameters (HSPs), can indicate cocrystal formation and guide cocrystal screening. It was also our aim to evaluate various HSPs-based approaches in miscibility prediction. HSPs for indomethacin (the model drug) and over thirty coformers were calculated according to the group contribution method. Differences in the HSPs between indomethacin and each coformer were then calculated using three established approaches, and the miscibility was predicted. Subsequently, differential scanning calorimetry was used to investigate the experimental miscibility and cocrystal formation. The formation of cocrystals was also verified using liquid-assisted grinding. All except one of the drug-coformers that were predicted to be miscible were confirmed experimentally as miscible. All tested theoretical approaches were in agreement in predicting miscibility. All systems that formed cocrystals were miscible. Remarkably, two new cocrystals of indomethacin were discovered in this study. Though it may be necessary to test this approach in a wide range of different coformer and drug compound types for accurate generalizations, the trends with tested systems were clear and suggest that the drug and coformer should be miscible for cocrystal formation. Thus, predicting the miscibility of cocrystal components using solubility parameters can guide the selection of potential coformers prior to exhaustive cocrystal screening work.

  3. Hansen solubility parameter analysis on the dispersion of zirconia nanocrystals.

    Science.gov (United States)

    Wang, Sho-Hsun; Liu, Jia-Hong; Pai, Chin-Tung; Chen, Chien-Wei; Chung, Pao-Tang; Chiang, Anthony Shiaw-Tseh; Chang, Shinn-Jen

    2013-10-01

    Nanoparticle dispersible in a broad range of solvents is desirable when preparing an organic/inorganic nanocomposite. In this report, the dispersion behavior of carboxylate-grafted zirconia nanoparticle in 25 solvents covering a wide range of polarity was analyzed based on their Hansen solubility parameters (HSP). Particles grafted with alkyl-chain longer than four carbons could only be dispersed in non-polar solvents, while that grafted with acetic acid was dispersible in polar ones. However, particle modified with methacrylic acid (MA) was compatible with both types of solvents, which was rather unexpected. Further NMR analysis showed that the carboxylate-grafted samples contained a trace amount of triethanolamine (TEA) due to the particular ZrO2 synthesis process employed. The combination of the hydrophilic TEA ligand with the short hydrophobic tail of methacrylate broadened the range of compatible solvents from benzene to methanol. Such an extended solvent compatibility was observed previously only for nanoparticles covered with large polymer surfactants having both hydrophilic and hydrophobic groups. Achieving this with two small molecules having separate functional groups is crucial when one needs to maximize the inorganic content in a composite.

  4. Correlation of polymer performance and Hansen solubility parameters

    Science.gov (United States)

    Mania, Daniel Jobse

    Ready-to-use (RTU) grout is becoming more important to the finish and remodeling construction industry. Market research shows it to be a fast-growing product that not only is creating its own space but also is beginning to supplant existing technology. The original intent of this research was to investigate formulation parameters and how they affect grout performance. It was learned that particle size and oil absorption (OA) value are important filler properties that affect performance as much as adequate packing density and optimal pigment volume concentration (PVC) without going beyond critical PVC (CPVC). Polymer architecture was also determined to be extremely important, but difficult to predict. Properties such as tensile strength and elongation can be adequately modeled by polymer Tg, however, Tg alone is not a good predictor of hydrophobicity or stain repellency performance. This conundrum led to research into Hansen solubility parameters (HSP) and whether these could be used as performance predictive tools. Since HSP of polymers cannot be directly measured, Group Contribution Theory (GCT) had to be employed to estimate polymer HSP. It was determined that HSP is not as good of a performance predictor for physical strength properties, like tensile strength, as polymer Tg: but HSP does have utility for relative performance prediction of wet state properties such as hydrophobicity, stain repellency, or solvent resistance. It was further discovered that HSP may be useful with predicting relative performance of wet state properties such as wet tensile strength and elongation.

  5. [Some immunological aspects in the reaccional states of Hansen disease].

    Science.gov (United States)

    Rada, Elsa; Nacarid, Aranzazu; Convit, Jacinto

    2005-12-01

    The crucial clinical problem in leprosy is represented by episodes of intense inflammation that produce nerve damage. When Mycobacterium leprae has been eliminated by means of antibiotics, the death of the bacteria is not a complete solution to the damage caused in nerves. Two of the more frequent immunopathological phenomena in Hansen's disease are Type I, reactions, known as Reversal Reactions (RR), and Type II reactions, of which the most frequent and well known are those called Erythema Nodosum Leprosum (ENL). Type II reactions have been defined as an immunologic complication in multibacillary patients. Both types of reactions are accompanied mainly by the increase of pro-inflammatory cytokines TNF-alpha, IL-1, IL-2, IL-4, IL-6, IL-8, INF-gamma, IL-10, IL-12, among others. In a retrospective analysis of a population of 150 patients of the Central Service of Dermatology, Institute of Biomedicine, where these patients were subjected to Multidrug Therapy (MDT) and MDT + inmunotherapy (IMT), both groups presented type II reactions, but the group that additionally received inmunotherapy also presented type I reactions. In the group of patients that presented ENL, it appeared to be associated with the large amount of bacilli in their lesions.

  6. Bayo Azteca, primera variedad mejorada de frijol con resistencia a Apion godmani Wagner Bayo Azteca, first improved bean variety with resistance to Apion godmani Wagner

    Directory of Open Access Journals (Sweden)

    Ramón Garza-García

    2010-12-01

    Full Text Available Bayo Azteca, la primera variedad mejorada de frijol (Phaseolus vulgaris L., con resistencia a una plaga insectil, ha sido obtenida por el programa de frijol del Campo Experimental Valle de México, del Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias por cruzas múltiples, esto involucró un largo proceso de mejora genética. Bayo Azteca es la primera variedad mejorada resistente al picudo del ejote (Apion godmani Wagner, un curculiónido que ataca al frijol en las zonas templadas de los valles altos de la Mesa Central de México, causando pérdidas que varían desde 50% hasta 90%. Al igual que otras variedades es también resistente a antracnosis [Colletotrichum lindemuthianum (Sacc & Magn. Briosi & Cav.] y tizón común [Xanthomonas campestris pv phaseoli (Smith Dye]. La nueva variedad fue desarrollada para los Valles Altos de la mesa central desde 1 800 a 2 300 m de altitud. Su hábito de crecimiento es indeterminado tipo III, guías cortas y flor blanca, las vainas son de tamaño mediano a grandes con 5 a 6 granos medianos, tiene alto potencial de rendimiento y plasticidad fenológica. En los Valles Altos, es de precocidad intermedia (102 a 118 días a madurez; Bayo Azteca es además de rápida cocción y con alto contenido de proteína.Bayo Azteca, the first improved bean variety (Phaseolus vulgaris L., with resistance to an insect plague, has been obtained via multiple crossing by bean program of the Valley of Mexico Experimental Station (CEVAMEX, of the National Research Forestry, Agriculture and Livestock Institute (INIFAP, which required a long process of genetic improvement. Bayo Azteca is the first improved variety resistant to bean pod weevil (Apion godmani Wagner, which is a curculionidae that attacks beans in template zones of the Central Highlands of Mexico and causes 50-90% losses. Similar to other varieties, the Bayo Azteca is resistant to anthracnose [Colletotrichum lindemuthianum (Sacc & Magn. Briosi

  7. MAPEAMENTO DA SUSCEPTIBILIDADE A DESLIZAMENTOS NA BACIA HIDROGRÁFICA DO CAETÉ, ALFREDO WAGNER/SC

    Directory of Open Access Journals (Sweden)

    Leandro Redin Vestena

    2010-01-01

    Full Text Available Este artículo tiene como objetivo identifi car y mapear la susceptibilidad de deslizamientos de tierra en la cuenca hidrográfi ca del municipio de Caeté Alfredo Wagner/SC, región montañosa del Estado de Santa Catarina. Se utilizó el modelo SINMAP (Stability Index Mapping para determinar el indice de estabilidad de taludes por medio de la combinación de un modelo hidrológico con un de estabilidad de taludes. Los resultados obtenidos mostran la presencia de zonas con elevado grado de inestabilidad de las laderas y con grado de estabilidad intermedia, que pueden ser fácilmente alteradas por actividades humanas, principalmente por la eliminación de la cubertura vegetal. El conocimiento previo de las zonas susceptibles a deslizamientos y resbalos subvencionan acciones de prevención y mitigación.

  8. Digital scenography and the mimetic aporia of Richard Wagner's Ring Cycle

    Directory of Open Access Journals (Sweden)

    Jason R. D’Aoust

    2015-12-01

    Full Text Available This article explores the visual friction between the concealment of technology and the need to stage mimetic scenes in Richard Wagner's Der Ring des Nibelungen. The article relies on the critical reception of the Wagnerian Gesamtkunstwerk in musicology, as well as in media, performance, and theatre studies. Drawing on productions and commentaries critical of the iconic Gesamtkunstwerk's attempted retrieval of a lost natural state, the article examines correlations between phantasmagoria, special effects, movement detection technology, and the interactive devices of multimedia and digital scenography. These correlations are framed within a theoretical methodology of historical discourse and media archaeologies. Three specific productions of the Ring are discussed, namely the inaugural and centenary productions at the Bayreuth Festspielhaus, as well as Robert Lepage's production for the Metropolitan Opera of New York in 2010–2012.

  9. Maxwell-Wagner-Silars relaxations due to glass occlusions in a thermoset composite

    Science.gov (United States)

    Aldrich, P. D.; McGee, R. L.; Yalvaç, S.; Bonekamp, J. E.; Thurow, S. W.

    1987-12-01

    Maxwell-Wagner-Silars (MWS) dielectric relaxations have been studied in thermoset composites made with hollow glass microspheres and reinforced with aramid fiber. Over the temperature range reported (140-230 °C) the glass microspheres show a conductivity of 10-10-10-5 (Ω cm)-1 so that MWS loss peaks fall in the 102-105 Hz frequency range. The apparent activation energy for the relaxation is about 20 kcal/mole. The observed MWS relaxation times depend only on temperature and not on volume fraction of microspheres as predicted by MWS theory. Also, the enhancement of activation energy for the relaxation over the activation energy for conduction of the glass seems to be explainable from the standpoint of the frequency and temperature dependence of the glass dielectric constant.

  10. Rapid Communication. Tamarixia monesus (Walker (Hym.: Eulophidae parasitoid of Bactericera tremblayi (Wagner, 1961 (Hemiptera: Triozidae in Iran

    Directory of Open Access Journals (Sweden)

    Lotfalizadeh Hossein

    2016-08-01

    Full Text Available Bactericera tremblayi (Wagner, 1961 (Hemiptera: Triozidae is reported on Brassica oleracea var. capitata (Brassicaceae in northwestern Iran. Tamarixia monesus (Walker (Hymenoptera: Chalcidoidea, Eulophidae was reared for the first time on B. tremblayi, and compared with Tamarixia tremblayi, another parasitoid of B. tremblayi. This is a new record of T. monesus from the Middle East.

  11. Efficient Nazarov cyclization/Wagner-Meerwein rearrangement terminated by a Cu(II)-promoted oxidation: synthesis of 4-alkylidene cyclopentenones.

    Science.gov (United States)

    Lebœuf, David; Theiste, Eric; Gandon, Vincent; Daifuku, Stephanie L; Neidig, Michael L; Frontier, Alison J

    2013-04-08

    The discovery and elucidation of a new Nazarov cyclization/Wagner-Meerwein rearrangement/oxidation sequence is described that constitutes an efficient strategy for the synthesis of 4-alkylidene cyclopentenones. DFT computations and EPR experiments were conducted to gain further mechanistic insight into the reaction pathways. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. REACTIONAL STATES IN MULTIBACILLARY HANSEN DISEASE PATIENTS DURING MULTIDRUG THERAPY

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    José A.C. NERY

    1998-11-01

    Full Text Available It is well known that reactions are commonplace occurrences during the course of leprosy disease. Stigmatization may even be attributable to reactions which are also responsible for the worsening of neural lesions. A cohort of 162 newly-diagnosed baciloscopically positive patients from the Leprosy Care Outpatient Clinic of the Oswaldo Cruz Foundation (FIOCRUZ was selected for this study. While 46% of the multibacillary (MB patients submitted to the 24 fixed-dose multidrug therapy (MDT regimen suffered reactions during treatment, it was found that all MBs were susceptible and that constant attention and care were required at all times. Fourteen per cent were classified as BB, 52% as BL, and 33% as LL. None of the variables under study, such as, sex, age, clinical form, length of illness, length of dermatological lesions, baciloscopic index (BI, or degree of disability proved to be associate with reaction among the patients studied. Reversal Reaction (RR occurred in 45%, and Erythema Nodosum Leprosum (ENL occurred in 55%. Among BB patients who developed reactions (15 patients, 93% presented RR; while among the LL patients who developed reactions (34 patients, 91% presented ENL. Likewise, ENL was very frequent among those with disseminate lesions, while RR was most often observed in patients with segmentary lesions. RR was also most likely to occur during the initial months of treatment. It was demonstrated that the recurrence rate of ENL was significantly higher than that of RR. Neither grade of disability nor BI was shown to be associated with RR and ENL reaction. However, the RR rate was significantly higher among patients showing BI 3.Reações são ocorrências comuns no curso da hanseníase e são responsáveis pelo agravamento das lesões neurais. Uma coorte de 162 pacientes recém-diagnosticados, baciloscopicamente positivos, em acompanhamento no Ambulatório de Hanseníase da Fundação Oswaldo Cruz (FIOCRUZ foi selecionada para estudo

  13. Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions.

    Science.gov (United States)

    Legendre, Davey P; Muzny, Christina A; Swiatlo, Edwin

    2012-01-01

    Hansen's disease, also known as leprosy, remains an important public health problem throughout the world, including North America. The causative microbe in Hansen's disease is Mycobacterium leprae, an acid-fast organism that is difficult to grow in vitro. The nine-banded armadillo is the major animal reservoir in the United States. Manifestations of disease vary based on host immune response and can range from tuberculoid to lepromatous leprosy (paucibacillary to multibacillary disease). Hansen's disease typically affects the skin, nerves, and eyes, and patients may present with skin lesions, weakness, numbness, eye pain, or loss of vision. Definitive diagnosis is based on a combination of physical examination findings and skin biopsy and/or smear. Modern antibacterial therapy typically consists of combinations of dapsone and rifampin with or without clofazimine. Clofazimine is available only as an investigational drug through the National Hansen's Disease Program. Other options include moxifloxacin, ofloxacin, minocycline, and clarithromycin. Hansen's disease is associated with type 1 (reversal) and type 2 (erythema nodosum leprosum) immunologic reactions, during which the disease process appears to worsen dramatically. These reactions may occur at any time before, during, or after treatment. Antibacterial therapy should usually be continued during these reactions. Treatment options for these reactions differ based on clinical manifestations and include corticosteroids, thalidomide, pentoxiphylline, tumor necrosis factor inhibitors, and T cell inhibitors. Prompt diagnosis, antimicrobial therapy, and treatment of reactions dramatically reduce complications of the disease. © 2012, Pharmacotherapy Publications, Inc.

  14. Hansen's disease recoverers as agents of change: a case study in Japan.

    Science.gov (United States)

    Hosoda, Miwako

    2010-03-01

    This manuscript addresses the role and contribution of people affected by Hansen's disease (leprosy), especially through the efforts of Zen-Ryo-Kyo, the National Hansen's Disease Sanatoria Residents' Association, in changing laws and attitudes in Japan since the 1950's. Health social movements are discussed in the Japanese context and more broadly. An important contribution of this manuscript is the explanatory description of the activities of Zen-Ryo-Kyo in achieving change through addressing issues related to social stigma and discrimination. The argument is made for expanding the scope of social movements to include all stigmatised illnesses and disabilities. Another significant point discussed is the need to move beyond defining Hansen's disease in medical and legal terms, and to redefine it as a public health and social issue to be solved.

  15. Treatment of leprosy/Hansen's disease in the early 21st century.

    Science.gov (United States)

    Worobec, Sophie M

    2009-01-01

    Leprosy, or Hansen's disease (HD), is caused by Mycobacterium leprae, a slowly dividing mycobacterium that has evolved to be an intracellular parasite, causing skin lesions and nerve damage. Less than 5% of people exposed to M. leprae develop clinical disease. Host cell-mediated resistance determines whether an individual will develop paucibacillary or multibacillary disease. Hansen's disease is a worldwide disease with about 150 new cases reported annually in the United States. Effective anti-mycobacterial treatments are available, and many patients experience severe reversal and erythema nodosum leprosum reactions that also require treatment. Leprosy has been the target of a World Health Organization multiple drug therapy campaign to eliminate it as a national public health problem in member countries, but endemic regions persist. In the United States, the National Hansen's Disease Program has primary responsibility for medical care, research, and information.

  16. Anterior segment optical coherence tomography findings of iris granulomas in Hansen's disease: a case report.

    Science.gov (United States)

    Mahendradas, Padmamalini; Avadhani, Kavitha; Ramachandran, Sarika; Srinivas, Sahana; Naik, Madhavi; Shetty, K Bhujang

    2013-02-11

    A 50-year-old male was diagnosed to have a right eye sclerouveitis and left eye granulomatous anterior uveitis due to Hansen's disease. We are reporting the anterior segment optical coherence tomography (ASOCT) findings of iris granuloma in this case. Skin biopsy revealed plenty of acid fast bacilli with a bacteriological index of 5 suggestive of multibacillary polar lepromatous leprosy. ASOCT revealed well-demarcated smooth-surfaced nodular lesion with internal hyporeflectivity corresponding to the areas of granuloma which decreased in size following treatment with antileprosy drugs and systemic and topical steroids. ASOCT is a non-invasive technique to assess the extent of involvement of anterior segment in Hansen's disease and is a useful tool in follow-up. This is also the first report on ASOCT findings of iris granuloma in Hansen's disease.

  17. [The compulsory isolation of Hansen's disease patients: memories of the elderly].

    Science.gov (United States)

    de Castro, Selma Munhoz Sanches; Watanabe, Helena Akemi Wada

    2009-01-01

    From 1924 to 1962, Brazil used compulsory internment of Hansen's disease patients as one of the ways of controlling the disease in the community. After this policy ended, many patients continued to live in these units. The former Asilo Pirapitingui, now the Hospital Dr. Francisco Ribeiro Arantes, is the only old-style asylum for the socially determined internment of those suffering from Hansen's disease. Through recorded and transcribed interviews of eight of those remaining, we sought to learn their history and the meaning of this isolation in their lives. The thematic analysis of the discourse enabled identification of the following analysis categories: Hansen's disease; internment day-to-day life; the institution; current health conditions; and staying in the institution after the end of compulsory internment.

  18. Hansen's disease in the state of Amazonas: policy and institutional treatment of a disease.

    Science.gov (United States)

    Schweickardt, Julio Cesar; Xerez, Luena Matheus de

    2015-12-01

    This article discusses the historical aspects of the policies for controlling Hansen's disease in the state of Amazonas from the second half of the nineteenth century until the dismantling of this model in 1978. We present the historical changes in the local institutions and policies, and their relationship with national policies. The history and policies related to Hansen's disease in the state of Amazonas are analyzed through the following institutions: Umirisal, the Oswaldo Cruz Dispensary, the Paricatuba Leprosarium, the Antônio Aleixo Colony, and the Gustavo Capanema Preventorium. We seek to show that these institutions cared for the people who suffered from Hansen's disease and those related to them, and were also responsible for carrying out the policies for fighting and controlling the disease.

  19. [What Hansen's disease research learned from tuberculosis research: from molecular biological aspect].

    Science.gov (United States)

    Suzuki, Yasuhiko; Yamaguchi, Tomoyuki; Kim, Hyun; Yokoyama, Kazumasa; Nakajima, Chie

    2014-12-01

    As for the Mycobacterium leprae which is a causative agent of Hansen's disease, many studies had been done since it was identified in 1873. However, those studies, at the same time, experienced many struggles because of the difficulty of culture of M. leprae on the artificial growth media. Hence, the study of Hansen's disease progressed by taking the knowledge from the study of tuberculosis caused by the bacteria belonging to the same genus, genus Mycobacterium. For instance, the knowledge of mutations in specific genes responsible for rifampicin- and quinolone-resistance in M. tuberculosis led the elucidation of drug-resistant acquisition mechanism of M. leprae. Similarly, it is necessary for the researcher of Hansen's disease to get important information from the latest topic of the tuberculosis study and utilize them to the study of the disease.

  20. [History for animal model of Hansen's disease and characteristics of leprosy in hypertensive nude rat].

    Science.gov (United States)

    Yogi, Yasuko; Fujimura, Takao; Suzuki, Koichi

    2008-09-01

    The long search of an animal model for leprosy were carried out as many researchers since the Mycobacterium leprae discovery by Dr. Hansen in 1874. The remarkable results were left after the development of the foot-pad method by Dr. Shepard in 1960. The introduction of the T-R mouse and athymic (nude) mouse for leprosy research, alsospontaneity examples of Hansen's disease was reported to armadillo, chimpanzee and mangabay monkey, and it was confirmed that Hansen's disease was the zoonosis. Although, We have established a congenic hypertensive nude rat, SHR/NCrj-rnu (SHR.F344-Foxn(rnu)), carrying nude (rnu) and hypertension genes. SHR/NCrj-rnu rats obtained showed high susceptibility to M. leprae and showed a characteristic disease with a progressive pattern of leproma formation. Also this hypertensive nude rat strain produce high level of IL-10. Therefore, congenic hypertensive nude rat may be useful for an animal model to leprosy.

  1. Social representation of Hansen's disease thirty years after the term 'leprosy' was replaced in Brazil

    Directory of Open Access Journals (Sweden)

    Oliveira Maria Leide Wand-del-Rey de

    2003-01-01

    Full Text Available Based on the theories of social representation (SC and Central Core (CC, a structural study was undertaken regarding the neologism hanseníase (Hansen's disease, the term adopted by Brazil's Ministry of Health in the 1970s. Carried out during 2001, this study interviewed eight hundred housewives residing in the Rio de Janeiro and Duque de Caxias municipalities. It found that Hansen's disease is part of a process of modernization of common thinking, anchored in the traditional representation of leprosy. This finding is understandable from the perspective that the central structure of a social representation has a historical determination, so short- and middle-term changes are not to be expected. Furthermore, there has been no ongoing investment in social marketing to make the new terminology more widely known. The authors discuss the relation between social representation and the concept of the history of mentalities.

  2. Prediction of Hansen Solubility Parameters with a New Group-Contribution Method

    Science.gov (United States)

    Stefanis, Emmanuel; Panayiotou, Costas

    2008-04-01

    A group-contribution method for the estimation of Hansen solubility parameters of pure organic compounds is presented. It uses two kinds of characteristic groups: first-order groups that describe the basic molecular structure of compounds and second-order groups, which are based on the conjugation theory and improve the accuracy of predictions. A large variety of characteristic groups ensure the prediction of Hansen solubility parameters for a broad series of organic compounds, including those having complex multi-ring, heterocyclic, and aromatic structures. The predictions are exclusively based on the molecular structure of compounds, and no experimental data are needed. The predicted values permit a fairly reliable selection of solvents based on the radius of a Hansen solubility parameter sphere or on a Teas parameter ternary plot. Especially designed algorithms permit the preparation of a list of new molecular structures which, if synthesized, could be the ideally suited solvents for a series of corresponding applications.

  3. O imaginário religioso de pacientes de hanseníase: um estudo comparativo entre ex-internos dos asilos de São Paulo e atuais portadores de hanseníase The religious imaginary of Hansen's disease patients: a comparative study of former inmates of the asylums of São Paulo and current Hansen's disease patients

    Directory of Open Access Journals (Sweden)

    André Gonçalves Mellagi

    2009-06-01

    Full Text Available Analisa a religiosidade de pacientes portadores de hanseníase que viveram dois períodos distintos da história do tratamento dos doentes: o do internamento em asilos e o da prática atual. Dez entrevistas semiestruturadas focalizaram saúde, religião e hanseníase, abordando os meios de enfrentamento religioso nos dois grupos. No grupo de ex-internos, constatou-se a presença da religião institucionalizada, que atendia aos propósitos de vigilância e da terapêutica isolacionista. Os atuais portadores de hanseníase ainda sentem o peso do estigma da 'lepra' em determinadas situações. Foram aplicados também cinco questionários a profissionais de saúde do DHDS, que apresentam suas considerações sobre a religião do paciente e o tratamento.The article analyzes the religiosity of Hansen's disease patients who lived during two distinct treatment periods of the sick: that of internment in asylums and the current practice. Ten semi-structured interviews focused on health, religion and Hansen's disease, broaching the ways the two groups faced religion. In the former inmate group, the presence of institutionalized religion was noted, which served the purposes of vigilance and isolationist therapeutics. Present day Hansen's disease patients still feel the stigmatic weight of 'leprosy" in certain situations. Five questionnaires were also given to DHDS health professionals, who presented their considerations concerning the patient's religion and the treatment.

  4. Portador de hanseníase: impacto psicológico do diagnóstico

    OpenAIRE

    2014-01-01

    A hanseníase, na atualidade, ainda representa um problema de saúde pública que pode causar no indivíduo consequências psicossociais. Objetiva-se, neste trabalho, identificar os impactos psicológicos provocados no paciente após o diagnóstico da hanseníase. Os sujeitos envolvidos constituem-se por cinco indivíduos em tratamento no CREDEN-PES de Governador Valadares-MG, com faixa etária entre 36 e 70 anos. Realizaram-se entrevistas não estruturadas e gravadas. Os dados foram analisados segundo A...

  5. 42 CFR 22.1 - Duty at a station of the Service devoted to the care of Hansen's disease patients; additional pay.

    Science.gov (United States)

    2010-10-01

    ... care of Hansen's disease patients; additional pay. 22.1 Section 22.1 Public Health PUBLIC HEALTH... Hansen's Disease Duty by Personnel Other Than Commissioned Officers § 22.1 Duty at a station of the Service devoted to the care of Hansen's disease patients; additional pay. (a) Non-commissioned officers...

  6. Estudo do roedor Akodon arviculoides, Wagner, 1842 (Cricetidae: importância nos focos pestosos no Brasil The rodent Akodon arviculoides, Wagner, 1842 (Cricetidae: importance in plague focus of Brazil

    Directory of Open Access Journals (Sweden)

    Célio Rodrigues de Almeida

    1986-12-01

    Full Text Available Relata-se a ocorrência do roedor Akodon arviculoides (Wagner, 1842 no foco pestoso do Agreste pernambucano, sua capacidade de sobrevivência, reprodução e o desenvolvimento no cativeiro, a susceptibilidade à infecção pela Yersinia pestis e a importãncia desse roedor nos focos pestosos do Brasil.The occurrence of the rodent Akodon arviculoides Wagner, 1842 in the plague focus of the "Agreste" region of the State of Pernambuco and a report on its ability for survival, reproduction and development in captivity, its susceptibility to Yersinia pestis infection and the role of this rodent species in Brazilian plague foci are reported.

  7. Helenduvad nobelistid / Alar Karis

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2012-01-01

    Nobeli keemiapreemia saanud Columbia ülikooli bioloogi Martin Chalfie, California ülikooli teadlase Roger Tsieni ja Jaapani päritolu Woods Hole'i merebioloogialaboratooriumi emeriitprofessori Osamu Shimomura meduusi-uuringutest

  8. Geenide vaigistajad / Alar Karis

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2012-01-01

    2007. a. Nobeli meditsiini- ja füsioloogiapreemia pälvinud Mario Capecchi, Oliver Smithiesi ja Martin Evansi uurimistööde mõjust teaduse arengule ning Tartu Ülikooli transgeense tehnoloogia labori tegevusest

  9. Geenide vaigistajad / Alar Karis

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2007-01-01

    2007. a. Nobeli meditsiini- ja füsioloogiapreemia pälvinud Mario Capecchi, Oliver Smithiesi ja Martin Evansi uurimistööde mõjust teaduse arengule ning Tartu Ülikooli transgeense tehnoloogia labori tegevusest

  10. Helenduvad nobelistid / Alar Karis

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2012-01-01

    Nobeli keemiapreemia saanud Columbia ülikooli bioloogi Martin Chalfie, California ülikooli teadlase Roger Tsieni ja Jaapani päritolu Woods Hole'i merebioloogialaboratooriumi emeriitprofessori Osamu Shimomura meduusi-uuringutest

  11. Helenduvad nobelistid / Alar Karis

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2008-01-01

    Nobeli keemiapreemia saanud Columbia ülikooli bioloogi Martin Chalfie, California ülikooli teadlase Roger Tsieni ja Jaapani päritolu Woods Hole'i merebioloogialaboratooriumi emeriitprofessori Osamu Shimomura meduusi-uuringutest

  12. Surprise! Neural Correlates of Pearce-Hall and Rescorla-Wagner Coexist within the Brain

    Science.gov (United States)

    Roesch, Matthew R; Esber, Guillem R; Li, Jian; Daw, Nathaniel D; Schoenbaum, Geoffrey

    2011-01-01

    Learning theory and computational accounts suggest that learning depends on errors in outcome prediction as well as changes in processing of or attention to events. These divergent ideas are captured by models, such as Rescorla-Wagner (RW) and temporal difference (TD) learning on one hand, which emphasize errors as directly driving changes in associative strength, versus models such Pearce-Hall (PH) and more recent variants on the other hand, which propose that errors promote changes in associative strength by modulating attention and processing of events. Numerous studies have shown that phasic firing of midbrain dopamine neurons carries a signed error signal consistent with RW or TD learning theories, and recently we have shown that this signal can be dissociated from attentional correlates in the basolateral amygdala and anterior cingulate. Here we will review this data along with new evidence 1) implicating habenula and striatal regions in supporting error signaling in midbrain dopamine neurons and 2) suggesting that central nucleus of the amygdala and prefrontal regions process the amygdalar attentional signal. However while the neural instantiations of the RW and PH signals are dissociable and complementary, they may be linked. Any linkage would have implications for understanding why one signal dominates learning in some situations and not others and also for appreciating the potential impact on learning of neuropathological conditions involving altered dopamine or amygdalar function, such as schizophrenia, addiction, or anxiety disorders. PMID:22487047

  13. Nonmonotonic dynamics in Lifshitz-Slyozov-Wagner theory: Ostwald ripening in nanoparticle catalysts

    Science.gov (United States)

    Rinaldo, Steven G.; Lee, Wendy; Stumper, Jürgen; Eikerling, Michael

    2012-10-01

    Nanoparticle catalysts dispersed on high-surface-area electronic support materials are used in a wide range of applications. Nano-sized particles afford a high active surface area per unit volume of an electrocatalytic medium. However, the gain in active surface area for desired surface reactions is offset in part by enhanced rates of degradation processes that cause losses in catalyst mass, catalyst surface area, and electrocatalytic activity. A dynamic model of surface-area-loss phenomena based on the theories of Lifshitz and Slyozov [J. Phys. Chem. Solids0022-369710.1016/0022-3697(61)90054-3 19, 35 (1961)], Wagner [Z. Elektrochem. 65, 581 (1961)], and Smoluchowski [Z. Phys. Chem. 92, 129 (1917)] is presented. A population balance equation in particle space accounts for nanoparticle dissolution, redeposition, and coagulation. It relates kinetic rates of these processes to the evolution of the particle-size distribution and its moments. Our analysis of the temporal dynamics of the number density, mean radii, surface area, and mass moments focuses on the important case of reaction-limited Ostwald ripening. Transient solutions reveal unique scaling relationships between the moments of the evolving distribution. Diagnostic criteria established from the scaling relationships are applied to previously published experimental degradation data for supported nanoparticle catalysts in polymer electrolyte fuel cells.

  14. Purkinje cell activity during classical conditioning with different conditional stimuli explains central tenet of Rescorla–Wagner model [corrected].

    Science.gov (United States)

    Rasmussen, Anders; Zucca, Riccardo; Johansson, Fredrik; Jirenhed, Dan-Anders; Hesslow, Germund

    2015-11-10

    A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond to two distinct conditional stimuli and to a compound stimulus, we provide evidence that could potentially help explain the somewhat counterintuitive overexpectation phenomenon, which was derived from the Rescorla-Wagner model.

  15. La ley de Wagner versus la hipótesis keynesiana: el caso de México, 1950-2009

    Directory of Open Access Journals (Sweden)

    Domingo Rodríguez Benavides

    2013-01-01

    Full Text Available Se examina la ley de Wagner y la hipótesis keynesiana para el caso de México durante el periodo 1950-2009. La primera establece que el crecimiento del gasto público se explica como resultado de la actividad económica, mientras que la segunda postula lo contrario. Para tal fin se estiman tres diferentes especificaciones propuestas, respectivamente, por: 1 Peacock y Wiseman (1961, 2 Musgrave (1969 y 3 Gupta (1967 y Michas (1975. Los resultados encontrados revelan que las dos primeras especificaciones muestran evidencia a favor de la ley de Wagner, lo cual tiende a reforzarse por la dirección de las pruebas de causalidad efectuadas a los modelos de vectores autorregresivos (VAR estimados.

  16. Use of the theory of Lifshitz-Slyosov-Wagner for the evaluation of the aqueous solubility of dodecane

    CERN Document Server

    Espinoza, Loredana; Rivas, Issarly; Urbina-Villalba, German

    2016-01-01

    The solubility of dodecane was determined using the theory of Lifshitz-Slyosov-Wagner for the Ostwald ripening phenomenon. For this purpose, a set of dodecane in water nanoemulsions stabilized with sodium dodecylsulfate was prepared. The average cubic radius of the dispersions was followed as a function of time for volume fractions between 0.001 and 0.00001. The correct solubility (5.5 x 10-9 m3/m3) was only reproduced by the most dilute system.

  17. Tundmatud kohad ja asjade loomus / Katrine Gram Sloth, Johna Hansen ; intervjueerinud Laura Põld

    Index Scriptorium Estoniae

    Gram Sloth, Katrine, 1983-

    2016-01-01

    Taani kunstnik Katrine Gram Sloth ja Rootsi arhitekt Johna Hansen räägivad oma lapsepõlvest, kunstnikuteest, loomingust. Johna Hanseni jaapanipärasest einelaua installatsioonist "Laud" (2015-2016), Katrine Gram Slothi Islandil loodud teosest "Vista Revisited" (2015)

  18. Memories and history of Hansen's disease in Brazil told by witnesses (1960-2000

    Directory of Open Access Journals (Sweden)

    Maciel Laurinda Rosa

    2003-01-01

    Full Text Available This report is a preliminary result of a survey on memories and history of Hansen's disease, or 'hanseniasis', prepared by the Fundação Oswaldo Cruz (Fiocruz and the Universidade Federal do Rio de Janeiro (UFRJ using statements from those who have been afflicted by the disease or those that have fought against it. It outlines the methodology used by the authors and gives a succinct history of Hansen's disease in Brazil, together with information on the stage of the survey with extracts from our archives of statements. The founding and the role of Movement for the Reintegration of People Afflicted by Hansen's Disease (Morhan are explained in the testimony of Thomas Frist, a social scientist who worked in Brazil in the 1970s and 1980s, when the country's old colonies were being restructured, and Cristiano Torres, a former patient who spent time in prevention centers and leproseries in Pará state and who is now active in proposing new policy for the control of Hansen's disease.

  19. [Life experiences of Korean patients with Hansen's disease in Sorok Island Hospital].

    Science.gov (United States)

    Yang, Ya Ki

    2014-12-01

    The purpose of this study was to identify life experiences of Korean patients with Hansen's disease (leprosy). For this study, 5 participants from Sorok Island Hospital were purposively chosen. Data were collected through in-depth individual interviews from June to July 2014. Data analysis method was based on Colaizzi's approach. The study results showed that experiences of patients with Hansen's disease consisted of 14 themes and six theme clusters: 1) Bad disease approaching as fate; 2) Family breakup and far from the village; 3) New life in Sorok Island Hospital; 4) Treatment of Hansen's disease and disability; 5) Life in the disease community; 6) Comfort and hope of life. The findings of this study indicate that health care professionals should pay attention to patients with Hansen's disease not only to reduce their physical and psychological suffering, but also to help the community and public culture to reduce the social stigma surrounding this disease and causing suffering for the patients. The results of the present study can help us to have a better understanding of various aspects of patients' lived experiences.

  20. Comment on "K. Hansen, Int. J. Mass Spectrom. 399-400 (2016)51"

    CERN Document Server

    Holmlid, Leif

    2016-01-01

    The comment by K. Hansen suggests that the time-of-flight mass spectrometry data in one table in our paper from 2103 in IJMS should be due to a proton contamination and correspond to protons p instead of deuterons D. The evidence for such a suggestion is a re-plotting of our data, giving a bond distance of 5.0 pm instead of 2.3 pm, corresponding to state s = 3 instead of s = 2 in the ultra-dense hydrogen. However, protium has indeed been studied on the next pages in our paper, giving shorter time-of-flights as expected. A replotting of our protium results as suggested by Hansen gives a best fit mass of 0.6 u, showing that the suggested procedure gives consistently too small mass. Hansen also rejects the rotational energy transfer model as due to our use of D in the analysis of the data. However, this model has been applied successfully in two previous publications, including experiments using protium. Hansen also suggests that the protium is due to a contamination of the source; however, the gas feed (H2 or D...

  1. Reaffirming the Role of Science and Diversity in Counseling: A Reply to Hansen

    Science.gov (United States)

    Brady-Amoon, Peggy

    2012-01-01

    Overall, Hansen (2012a) and the author (Brady-Amoon, 2012) share a humanistic vision for the future of counseling. In this continued dialogue, the author argues that a broad-based philosophy of science that encompasses renewed respect for diversity remains essential for the future of the profession.

  2. Gerhard Henrik Armauer Hansen (1841-1912)--100 years anniversary tribute.

    Science.gov (United States)

    Grzybowski, Andrzej; Kluxen, Guido; Pótorak, Klaudia

    2014-05-01

    2012 marks the 100th year of death of Gerhard Henrik Armauer Hansen (1841-1912), who discovered Mycobacterium leprae, but also gave the first systematic scientific work on the leprosy of the eye. The article reviews his life and scientific achievements with special regard to eye and ophthalmology.

  3. Surviving the "School of Slavery": Acculturation in Sharon Draper's "Copper Sun" and Joyce Hansen's "The Captive"

    Science.gov (United States)

    Chandler, Karen Michele

    2016-01-01

    Although children's literature has long alluded to cultural connections between Africans and African Americans, very few texts establish clear lines of influence between particular African ethnic groups and African American characters and communities. Joyce Hansen's "The Captive" (1994) and Sharon Draper's "Copper Sun" (2006)…

  4. Further Extending the Humanistic Vision for the Future of Counseling: A Response to Hansen

    Science.gov (United States)

    Brady-Amoon, Peggy

    2012-01-01

    This article offers additional support for Hansen's (2012) position that humanism and a renewed respect for human complexity are essential to counseling. In the article, the author also speaks to the critical importance of continuing to ground the profession in art and science. Implications for the future of humanism and counseling are presented.

  5. An Interview with Sunny Hansen: Pioneer and Innovator in Counseling and Career Development

    Science.gov (United States)

    Skovholt, Thomas S.; Hage, Sally M.; Kachgal, Mera M.; Gama, Elizabeth Pinheiro

    2007-01-01

    During her 45-year career, Sunny Hansen was a pioneer and innovator in counseling and career development. She has lived the holistic life about which she writes and teaches. In this interview, she discussed the major influences on her life, the evolution of her professional career from English and journalism teacher to counselor and counselor…

  6. Cheiridium tetrophthalmum Daday, a new synonym of Larca lata (Hansen (Pseudoscorpiones, Larcidae

    Directory of Open Access Journals (Sweden)

    Harvey, Mark S.

    2011-07-01

    Full Text Available Cheiridium tetrophthalmum Daday, 1889 is removed from the synonymy of Geogarypus minor (L. Koch, 1873, and treated as a junior synonym of Larca lata (Hansen, 1884. The distribution of Larca lata and Geogarypus minor is documented, and L. lata is recorded from Hungary for the first time.

  7. Tundmatud kohad ja asjade loomus / Katrine Gram Sloth, Johna Hansen ; intervjueerinud Laura Põld

    Index Scriptorium Estoniae

    Gram Sloth, Katrine, 1983-

    2016-01-01

    Taani kunstnik Katrine Gram Sloth ja Rootsi arhitekt Johna Hansen räägivad oma lapsepõlvest, kunstnikuteest, loomingust. Johna Hanseni jaapanipärasest einelaua installatsioonist "Laud" (2015-2016), Katrine Gram Slothi Islandil loodud teosest "Vista Revisited" (2015)

  8. [The value of methods of bone regeneration evaluation in limb lengthening by the Wagner, Ilizarov methods and by physeal distraction].

    Science.gov (United States)

    Tesiorowski, Maciej; Kacki, Wojciech; Jasiewicz, Barbara; Rymarczyk, Adrian; Sebastianowicz, Piotr

    2005-01-01

    Limb lengthening is a long-lasting process, and during new bone formation different complications may occur. Due to this, early diagnosis of disturbances of new bone formation leading to such complications is of importance. The goal of this study is to analyze already used methods of regenerate evaluation. Material consists of retrospective data of 237 patients, who underwent limb lengthening between 1983 and 2002 by one of three methods: Wagner method, Ilizarow method and physeal distraction. During femoral lengthening by Wagner method appropriate shape of regenerate according to Hamanishi was observed in 9 cases (29.0%), and during tibia lengthening--only in 1 case (6.7%). During femoral lengthening by physeal distraction appropriate shape of regenerate (A or B according to Hamanishi) was observed in 24 cases (77.4%), and during tibia lengthening--in 11 cases (78.6%). During femoral lengthening by Ilizarow method appropriate shape of regenerate was observed in 51 cases (72.9%), and during tibia lengthening--in 46 cases (66.7%). Only in Wagner method a correlation between abnormal regenerate shape and bone consolidation complications was noted. Methods of evaluation of bone regeneration during distraction osteogenesis give only descriptive assessment. So far parameters applied for evaluation of distraction osteogenesis in Ilizarow method and physeal distraction do not allow for detailed assessment of bone regeneration process.

  9. [Prevalence of dry eye in Hansen's disease patients from a colony hospital in Goiânia, Brazil].

    Science.gov (United States)

    Frazão, Karys Carvalho; Picolo, Naira Bernardes; Hanouche, Rosana Zacarias; Santos, Procópio Miguel dos; Santos, Regina Cândido Ribeiro dos

    2005-01-01

    To determine the prevalence of dry eye in Hansen's disease patients from the "Hospital de Dermatologia Sanitária de Goiânia". The sample of the present study included 70 patients with Hansen's disease, from the "Hospital de Dermatologia Sanitária de Goiânia", and 30 controls, from the "Fundação Banco de Olhos de Goiás", both located in Goiânia-GO, Brazil. Ophthalmologic examination and Schirmer I, break-up time (BUT) and rose Bengal staining tests were carried out for all patients in a single evaluation. For the diagnosis of dry eye the Schirmer I equal or less than 5 mm and rose Bengal grade II or III, in at least one eye were considered. Forty-four (63.0%) patients with Hansen's disease were male and 22 (73.3%) controls were female (p=0.001). The mean age of the patients with Hansen's disease was 61.1+/-12.5 years and in the control group, it was 55.7+/-9.6 years. Fifteen (21.4%) patients with Hansen's disease and four (13.3%) controls presented with dry eye diagnosis (p=0.429). The lepromatous type (74.2%) of Hansen's disease was the most prevalent and dry eye (66.7%) was more frequent in this clinical form of the disease. The dry eye disease was more prevalent in patients with Hansen's disease, although the difference was not statistically significant.

  10. A revision of Megagraphydrus Hansen (Coleoptera, Hydrophilidae): synonymization with Agraphydrus Régimbart and description of seven new species.

    Science.gov (United States)

    Minoshima, Yûsuke N; Komarek, Albrecht; Ôhara, Masahiro

    2015-03-10

    The genus Megagraphydrus Hansen, 1999 is revised. Eleven of the twelve previously described species are recognized as valid, with Megagraphydrus wangi Hebauer, 2000 syn. nov. found to be a junior synonym of M. politus Hansen, 1999. Most significantly, Megagraphydrus itself is found to be a junior synonym of Agraphydrus Régimbart, 1903. The species are assigned to the subgenus Agraphydrus. This nomenclatural act results in the following new combinations: Agraphydrus (Agraphydrus) anhuianus (Hebauer, 2000) comb. nov., A. (A.) attenuatus (Hansen, 1999) comb. nov., A. (A.) jaechi (Hansen, 1999) comb. nov., A. (A.) luteilateralis (Minoshima & Fujiwara, 2009) comb. nov., A. (A.) malayanus (Hebauer, 2000) comb. nov., A. (A.) politus (Hansen, 1999) comb. nov., A. (A.) puzhelongi (Jia, 2010) comb. nov., A. (A.) regularis (Hansen, 1999) comb. nov., A. (A.) siamensis (Hansen, 1999) comb. nov., A. (A.) superans (Hebauer, 2000) comb. nov., and A. (A.) uvaensis (Hebauer, 2000) comb. nov. All species are redescribed with the exclusion of A. superans, A. luteilateralis, and A. puzhelongi. Seven new species are described: Agraphydrus (Agraphydrus) biprojectus sp. nov., A. (A.) coronarius sp. nov., A. (A.) decipiens sp. nov., A. (A.) insidiator sp. nov., A. (A.) masatakai sp. nov., A. (A.) montanus sp. nov., A. (A.) thaiensis sp. nov. Digital and SEM photographs are provided, and the male and female genital segments are illustrated and described.

  11. Uudised : RAMi lauljad Iisraelis. Lauluvõistlus Pärnus. Wagner, ka Eestis. Juuniküüditamise mälestuskontsert / Joosep Sang

    Index Scriptorium Estoniae

    Sang, Joosep

    2001-01-01

    Osa RAMi lauljaist osaleb Tel Avivis Iisraeli Uue Ooperi etendustel, B.Britteni ooperi "Billy Budd" lavastuses. Pärnus 2.-6. mail toimunud II Klaudia Taevi nim. noorte lauljate konkursi tulemustest. 17. mail EMAs toimuvast teaduskonverentsist "Richard Wagner, ka Eestis", 18. mail toimuvast galakontserdist ja näituse "Wagner Eesti laval" avamisest Estonia kontserdisaalis. 15. mail Narvas ja 16. mail Rakveres toimuvast Mozarti "Reekviemi" ettekandest juuniküüditamise mälestuseks

  12. Uudised : RAMi lauljad Iisraelis. Lauluvõistlus Pärnus. Wagner, ka Eestis. Juuniküüditamise mälestuskontsert / Joosep Sang

    Index Scriptorium Estoniae

    Sang, Joosep

    2001-01-01

    Osa RAMi lauljaist osaleb Tel Avivis Iisraeli Uue Ooperi etendustel, B.Britteni ooperi "Billy Budd" lavastuses. Pärnus 2.-6. mail toimunud II Klaudia Taevi nim. noorte lauljate konkursi tulemustest. 17. mail EMAs toimuvast teaduskonverentsist "Richard Wagner, ka Eestis", 18. mail toimuvast galakontserdist ja näituse "Wagner Eesti laval" avamisest Estonia kontserdisaalis. 15. mail Narvas ja 16. mail Rakveres toimuvast Mozarti "Reekviemi" ettekandest juuniküüditamise mälestuseks

  13. Der Schluss von Wagners Götterdämmerung und sein Zusammenhang mit der barocken ‘Licenza’

    Directory of Open Access Journals (Sweden)

    Büttner, Fred

    2011-12-01

    Full Text Available When Pietro Metastasio, at the beginning of the 1750s, reworked his famous libretto Didone abbandonata from 1724 for a performance in Madrid, he added a licenza, which is introduced by a detailed stage direction. To this stage direction the finale of Richard Wagner’s Götterdämmerung corresponds in a striking way, suggesting a dependence of the newer on the older piece. However, Wagner was not concerned with paying homage to an aristocratic leadership, which is what characterises the baroque licenza, but on the contrary with symbolically representing the end of the old society of gods by referring to an historic element.Cuando Pietro Metastasio, al comienzo de la década de 1750, reelaboró para una representación en Madrid su famoso libreto Dido abandonada de 1724, le añadió una licencia, que introdujo mediante una amplia didascalia escénica. El desarrollo del final del Crepúsculo de los dioses de Richard Wagner corresponde de forma evidente a esta didascalia escénica, lo que sugiere que el más reciente drama wagneriano depende del libreto precedente de Metastasio. Sin embargo, Wagner no consideró exaltar el poder aristocrático, típico de la licencia barroca, sino que, antes al contrario, se sirvió de un elemento histórico, característico de la antigua tradición del melodrama, para simbolizar el final de la vieja sociedad de los dioses mitológicos. [ge] Als Pietro Metastasio sein berühmtes Libretto Didone abbandonata von 1724 zu Beginn der 1750er Jahre für eine Aufführung in Madrid überarbeitete, fügte er eine Licenza an, die durch eine ausführliche Szenenanweisung eingeleitet wird. Mit dieser Szenenanweisung stimmt in auffälliger Weise der Schluss von Richard Wagners Götterdämmerung überein, so dass mit einer bewussten Anlehnung des neueren an das ältere Stück gerechnet werden darf. Jedoch geht es Wagner nicht um die Huldigung an ein aristokratisches Herrschertum, das die barocke Licenza kennzeichnet, sondern im

  14. Surprise! Neural correlates of Pearce-Hall and Rescorla-Wagner coexist within the brain.

    Science.gov (United States)

    Roesch, Matthew R; Esber, Guillem R; Li, Jian; Daw, Nathaniel D; Schoenbaum, Geoffrey

    2012-04-01

    Learning theory and computational accounts suggest that learning depends on errors in outcome prediction as well as changes in processing of or attention to events. These divergent ideas are captured by models, such as Rescorla-Wagner (RW) and temporal difference (TD) learning on the one hand, which emphasize errors as directly driving changes in associative strength, vs. models such as Pearce-Hall (PH) and more recent variants on the other hand, which propose that errors promote changes in associative strength by modulating attention and processing of events. Numerous studies have shown that phasic firing of midbrain dopamine (DA) neurons carries a signed error signal consistent with RW or TD learning theories, and recently we have shown that this signal can be dissociated from attentional correlates in the basolateral amygdala and anterior cingulate. Here we will review these data along with new evidence: (i) implicating habenula and striatal regions in supporting error signaling in midbrain DA neurons; and (ii) suggesting that the central nucleus of the amygdala and prefrontal regions process the amygdalar attentional signal. However, while the neural instantiations of the RW and PH signals are dissociable and complementary, they may be linked. Any linkage would have implications for understanding why one signal dominates learning in some situations and not others, and also for appreciating the potential impact on learning of neuropathological conditions involving altered DA or amygdalar function, such as schizophrenia, addiction or anxiety disorders. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.

  15. The New Apostolic Reformation: The critical reflections of the ecclesiology of Charles Peter Wagner

    Directory of Open Access Journals (Sweden)

    Kelebogile Resane

    2016-04-01

    Full Text Available Charles Peter Wagner is a well-known missiologist and ecclesiologist of the latest era. He is the author, trainer and prayer warrior who founded the New Apostolic Reformation (NAR that seeks to establish a fourth house. The NAR is a heterodox movement in Protestant Christianity sometimes known as the apostolic-prophetic movement, commonly associated with both the Pentecostal and Charismatic churches worldwide since the beginnings of the 1990s. Central to their theology is their locus of dogma that the task of the church, under the leadership of the apostles and prophets, is to take dominion of the earth within Christendom (distinct from Catholicism, Protestantism and Orthodox Christianity. The ekklesia is the people of God, whether they are gathered in their congregations on Sunday as the nuclear Church, or scattered in the workplace Monday through Saturday as the extended Church. The extended Church, just like the nuclear Church, is founded on apostles and prophets, but in the extended Church these are the different people who operate differently under a different rule book. It is these extended church leaders who will be most effective in transforming society. Workplace apostles are called to take dominion in business, government, arts and entertainment, media, family and education. Panoramically, Wagner’s ecclesiology, like mainstream evangelical ecclesiology, is trinitarian, communal, missiological and eschatological in nature and character. The weaknesses on his ecclesiology include the notions of polity based on fivefold ministries, balance of power and authority on church leadership, phenomenological approach to texts, exegetical shortcomings, and secular models in ecclesiastical governance.

  16. Seismic reflection-based evidence of a transfer zone between the Wagner and Consag basins: implications for defining the structural geometry of the northern Gulf of California

    Science.gov (United States)

    González-Escobar, Mario; Suárez-Vidal, Francisco; Hernández-Pérez, José Antonio; Martín-Barajas, Arturo

    2010-12-01

    This study examines the structural characteristics of the northern Gulf of California by processing and interpreting ca. 415 km of two-dimensional multi-channel seismic reflection lines (data property of Petróleos Mexicanos PEMEX) collected in the vicinity of the border between the Wagner and Consag basins. The two basins appear to be a link between the Delfín Superior Basin to the south, and the Cerro Prieto Basin to the north in the Mexicali-Imperial Valley along the Pacific-North America plate boundary. The seismic data are consistent with existing knowledge of four main structures (master faults) in the region, i.e., the Percebo, Santa María, Consag Sur, and Wagner Sur faults. The Wagner and Consag basins are delimited to the east by the Wagner Sur Fault, and to the west by the Consag Sur Fault. The Percebo Fault borders the western margin of the modern Wagner Basin depocenter, and is oriented N10°W, dipping (on average) ˜40° to the northeast. The trace of the Santa María Fault located in the Wagner Basin strikes N19°W, dipping ˜40° to the west. The Consag Sur Fault is oriented N14°W, and dips ˜42° to the east over a distance of 21 km. To the east of the study area, the Wagner Sur Fault almost parallels the Consag Sur Fault over a distance of ˜86 km, and is oriented N10°W with an average dip of 59° to the east. Moreover, the data provide new evidence that the Wagner Fault is discontinuous between the two basins, and that its structure is more complex than previously reported. A structural high separates the northern Consag Basin from the southern Wagner Basin, comprising several secondary faults oriented NE oblique to the main faults of N-S direction. These could represent a zone of accommodation, or transfer zone, where extension could be transferred from the Wagner to the Consag Basin, or vice versa. This area shows no acoustic basement and/or intrusive body, which is consistent with existing gravimetric and magnetic data for the region.

  17. Achados fonoaudiológicos na hanseníase: considerações teóricas Speech-language findings on Hansen's disease: theoretical considerations

    Directory of Open Access Journals (Sweden)

    Victor Gandra Quintas

    2009-01-01

    Full Text Available A hanseníase é uma doença que tem altos níveis de incidência no Brasil. De origem bacteriana crônica, com alta infectividade e baixa patogenicidade, tem como hospedeiro primário o homem e como agente etiológico o Mycobacterium leprae. O bacilo de Hansen, como também é conhecido o agente, se acumula principalmente na pele, nos nervos periféricos e pares cranianos, levando a diversas lesões cutâneas, também à perda da condução neural e, consequentemente, a severas alterações anatômicas e funcionais nas extremidades do corpo, como membros e região orofacial. De acordo com estas premissas, foi realizada uma revisão da literatura com intuito de mostrar a fisiopatologia da doença e sua classificação de acordo com as suas manifestações. Desta forma, a literatura, por intermédio de alguns estudos, mostrou que esta doença pode provocar alterações que comprometem significativamente a voz, a audição, os órgãos fonoarticulatórios e as funções estomatognáticas, tornando-se assim, de grande relevância à Fonoaudiologia.Hansen's disease is a malady that has high incidence levels in Brazil. It has a chronic bacterial origin, with high infectivity and low pathogenicity, having the man as its primary host, and the Mycobacterium leprae as its etiological agent. The Hansen's bacillus, as it is known, accumulates mainly in the skin, the peripheral nerves and the cranial nerves pairs, causing many skin lesions, as well as loss of neural conduction and, consequently, severe anatomical and functional changes in the ends of the body, such as members and the orofacial region. Based on these premisses, it was carried out a literature review in order to show the pathophysiology of the disease and its classification according to its manifestations. The literature review showed, through some studies, that the disease might cause alterations that significantly compromise the voice, the hearing, the phonoarticulatory organs, and the

  18. 22 tundi tõde ja õigust Anton Hansen Tammsaare moodi / Risto Berendson, Marika Rajamäe

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2008-01-01

    30. okt. kirjutati Anton Hansen Tammsaare sünniaastapäeva puhul alla lepingule, mis toob Vargamäele maratonetenduse kogu "Tõe ja õiguse" põhjal. Etendus toimub 21.-22. juunini. Kommenteerib Ülo Tonts

  19. Prevalence of musculoskeletal disorders and rheumatic disease in the Warao, Kari'ña, and Chaima indigenous populations of Monagas State, Venezuela.

    Science.gov (United States)

    Granados, Ysabel; Rosillo, Celenia; Cedeño, Ligia; Martínez, Yanira; Sánchez, Gloris; López, Geovalis; Pérez, Fernando; Martínez, Damarys; Maestre, Gabriela; Berbin, Sol; Chacón, Rosa; Stekman, Iván; Valls, Evart; Peláez-Ballestas, Ingris

    2016-07-01

    This study aimed to estimate the prevalence of musculoskeletal disorders and rheumatic diseases in the Warao, Kari'ña, and Chaima indigenous populations of Monagas State, Venezuela. A cross-sectional, analytical, community-based study was conducted in 1537 indigenous subjects ≥18 years old (38.6 % male, mean age 41.4 ± 17.5 years). The cross-culturally validated Community Oriented Program for the Control of Rheumatic Diseases (COPCORD) diagnostic questionnaire was applied. Subjects with a positive COPCORD diagnosis (either historic or current pain) were evaluated by primary care physicians and rheumatologists. A descriptive analysis was performed and comparisons made using analysis of variance and the chi-square test. Pain in the last 7 days was reported by 32.9 %, with pain intensity, according to a Likert-type scale [no pain, 195 (38.5 %); minimal pain, 231 (45.6 %); strong pain, 68 (13.4 %); intense pain, 5 (0.9 %)], 38.0 % reported historical pain, and 641 (41.7 %) had either historic or current pain. Of the COPCORD-positive subjects, pain most frequently occurred in the knee, back, and hands. Musculoskeletal and rheumatic diseases included osteoarthritis (14.1 %), back pain (12.4 %), rheumatic regional pain syndromes (RRPS) (9.7 %), undifferentiated arthritis (1.5 %), rheumatoid arthritis (1.1 %), and fibromyalgia (0.5 %). Chaima (18.3 %) and Kari'ña (15.6 %) subjects had a high prevalence of osteoarthritis, and Warao subjects had a high prevalence of low back pain (13.8 %). The prevalence of RRPS was high in all three ethnic groups. The Chaima group had the highest prevalence of rheumatic diseases, with 2.0 % having rheumatoid arthritis. This study provides useful information for health care policy-making in indigenous communities.

  20. Archaeology of the Recent Past at Kalawao: Landscape, Place, and Power in a Hawaiian Hansen's Disease Settlement

    OpenAIRE

    Flexner, James Lindsey

    2010-01-01

    Historical archaeology often focuses on the study of dispossessed, subaltern, or marginalized groups in the modern world. One such group is the community of the Hansen's disease (leprosy) settlement at Kalawao, Moloka`i, which was established by the Kingdom of Hawaii in 1865. The first people diagnosed by the state with Hansen's disease arrived in Kalawao in 1866, and around 1900 settlement shifted to the other side of Kalaupapa peninsula. Hawaii would not end its quarantine policy until 196...

  1. Efeito adverso do uso intermitente de rifampicina para tratamento de hanseníase

    Directory of Open Access Journals (Sweden)

    Priscila Maria de Oliveira Papaiordanou

    1988-10-01

    Full Text Available Os autores apresentam um caso de insuficiência renal aguda, hemólise aguda e trombocitopenia relacionada ao uso intermitente de Rifampicina para tratamento da Hanseníase. Estas reações adversas são observadas com extrema raridade na literatura mundial. A evolução da paciente foi benigna havendo recuperação total da função renal e regressão completa das alterações hematológicas. Este foi o primeiro registro no Brasil dos efeitos adversos da Rifampicina no tratamento de Hanseníase. São discutidos os principais aspectos patogênicos das alterações apresentadas e fez-se revisão da literatura existente sobre o assunto.

  2. [Hansen's disease in children under fifteen years-old in Jequitinhonha Valley, Minas Gerais, Brazil].

    Science.gov (United States)

    Lana, Francisco Carlos Félix; Amaral, Evaldo Pinheiro; Lanza, Fernanda Moura; Lima, Paula Lamounier; de Carvalho, Ana Cláudia Nascimento; Diniz, Letícia Gonçalves

    2007-01-01

    Hansen's disease has a slow evolution, which mostly affects the adult population. Detecting cases in children shows that the endemic continues and there is early exposure of the population to the bacillus. This is an ecological study with the objective of analyzing the occurrence of Hansen's disease in children under fifteen in the Jequitinhonha Valley through epidemiological and operational indicators. The results show that the endemic continues in the region, demonstrating that the health services are not proactive and must implement specific prevention and control measures for this age group in order to reduce the transmission of the disease and the possible damage it can bring to the life of individuals, especially when it affects them in their childhood.

  3. Iatrogenic stigma in outpatient treatment for Hansen's disease (leprosy) in Brazil.

    Science.gov (United States)

    White, Cassandra

    2008-02-01

    This paper explores how iatrogenic stigma, or stigma that is produced through a patient's encounter with physicians or with biomedicine in general, might emerge in outpatient treatment for Hansen's disease, or leprosy. Based on in-depth interviews with people affected by Hansen's disease and observations conducted at several public health clinics in Rio de Janeiro, Brazil, this research identified several aspects of the biomedical encounter that generated or contributed to stigma, either felt or enacted. Also noted in the research were positive examples of techniques used by physicians and health care workers for minimizing or circumventing stigma. The paper touches upon several topics, such as culturally mediated responses to medication side effects and communication between health care workers and patients, that might be salient or useful for health educators and others who are attempting to reduce health-related stigma.

  4. Fatal Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease.

    Science.gov (United States)

    Gopal, Vani; Mangaiyarkarasi, T; Gopal, R

    2014-01-01

    Klebsiella is a Gram-negative bacterium that causes different types of health care-associated infections including pneumonia, bloodstream infections, surgical site infections and meningitis. We report here a case of Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease. A middle-aged man with a known case of diabetes mellitus and Hansen's disease presented with the complaints of blurred vision in the left eye and the patient was found to have cataract. Patient was operated for cataract and Intraocular lens implanted. Patient developed headache and vomiting on the 4th post-operative day. Lumbar puncture was carried out and gram stain of cerebrospinal fluid showed Gram-negative bacilli in the direct smear and culture yielded a heavy growth of K. pneumoniae. The patient was treated with antimicrobials according to the susceptibility pattern. He initially showed improvement but later on developed altered sensorium and hypotension. Patient succumbed to infection in spite of all medical attention.

  5. Oral myiasis in an adult associated with filariasis and Hansen's disease.

    Science.gov (United States)

    Candamourty, Ramesh; Venkatachalam, Suresh; Yuvaraj, Vaithilingam; Sujee, Chembilary

    2013-01-01

    Oral myiasis is a common parasitic infestation of live human and animals caused by species of dipteran fly larvae known as maggots which may be secondary to medical disease. This case involves a 51-year-old female, poorly debilitated with advanced periodontal disease infected by the dipteral larvae in the anterior maxillary region which belonged to the family Calliphoridae and Chrysomya bezziana species. This lady was neglected from her family and presented oral myiasis with the previous history of filariasis and Hansen's disease. Secondary infestations may occur in cancrum oris, oral extraction wounds, jaw bone wounds, oral leprosy lesion, filariasis, and carcinoma. Hansen's disease (leprosy) is bacterial in origin whereas filariasis (elephantiasis) is parasitic in origin like-myiasis. The treatment consisted of manual removal of the larvae by topical application of turpentine oil, oral therapy, and surgical debridement of the oral wound.

  6. Kinetics of 12-Hydroxyoctadecanoic Acid SAFiN Crystallization Rationalized Using Hansen Solubility Parameters.

    Science.gov (United States)

    Rogers, Michael A; Marangoni, Alejandro G

    2016-12-06

    Changes in solvent chemistry influenced kinetics of both nucleation and crystallization of 12-hydroxyoctadecenoic, as determined using differential scanning calorimetry and applying a modified Avrami model to the calorimetric data. Altering solvent properties influenced solvent-gelator compatibility, which in turn altered the chemical potential of the system at the onset of crystallization, the kinetics of gelation, and the resulting 12HOA crystal fiber length. The chemical potential at the onset of crystallization was linearly correlated to both the hydrogen-bonding Hansen solubility parameter and the solvent-gelator vectorial distance in Hansen space, Ra. Our work suggests that solvent properties can be modulated to affect the solubility of 12HOA, which in turn influences the kinetics of crystallization and the self-assembly of this organogelator into supramolecular crystalline structures. Therefore, modulation of solvent properties during organogelation can be used to control fiber length and thus engineer the physical properties of the gel.

  7. Social representation of Hansen's disease thirty years after the term "leprosy" was replaced in Brazil.

    Science.gov (United States)

    Oliveira, Maria Leide Wand-del-Rey; Mendes, Carla Maria; Tardin, Rachel Tebaldi; Cunha, Mônica Duarte; Arruda, Angela

    2003-01-01

    Based on the theories of social representation (SC) and Central Core (CC), a structural study was undertaken regarding the neologism hanseniase (Hansen's disease), the term adopted by Brazil's Ministry of Health in the 1970s. Carried out during 2001, this study interviewed eight hundred housewives residing in the Rio de Janeiro and Duque de Caxias municipalities. It found that Hansen's disease is part of a process of modernization of common thinking, anchored in the additional representation of leprosy. This finding is understandable from the perspective that the central structure of a social representation has a historical determination, so short -and middle-term changes are not to be expected. Furthermore, there has been no ongoing investment in social marketing to make the new terminology more widely known. The authors discuss the relation between social representation and the concept of the history of mentalities.

  8. Eccentric first post-Newtonian waveforms for compact binaries in frequency domain with Hansen coefficients

    CERN Document Server

    Mikóczi, Balázs; Vasúth, Mátyás

    2015-01-01

    The inspiral and merger of supermassive black hole binary systems with high orbital eccentricity are among the promising sources of the advanced gravitational wave observatories. In this paper we derive analytic ready-to-use first post-Newtonian eccentric waveform in Fourier domain with the use of Hansen coefficients. Introducing generic perturbations of celestial mechanics we have generalized the Hansen expansion to the first post-Newtonian order which are then used to express the waveforms. Taking into account the high eccentricity of the orbit leads to the appearance of secular terms in the waveform which are eliminated with the introduction of a phase shift. The waveforms have a systematic structure and as our main result these are expressed in a tabular form.

  9. Extensive sonographic ulnar nerve enlargement above the medial epicondyle is a characteristic sign in Hansen's neuropathy.

    Science.gov (United States)

    Bathala, Lokesh; N Krishnam, Venkataramana; Kumar, Hari Kishan; Neladimmanahally, Vivekananda; Nagaraju, Umashankar; Kumar, Himanshu M; Telleman, Johan A; Visser, Leo H

    2017-07-01

    Earlier studies have shown sonographic enlargement of the ulnar nerve in patients with Hansen's neuropathy. The present study was performed to determine whether sonography or electrophysiological studies can detect the specific site of ulnar nerve pathology in leprosy. Eighteen patients (thirty arms) with Hansen's disease and an ulnar neuropathy of whom 66% had borderline tuberculoid (BT), 27% lepromatous leprosy (LL) and 7% mid-borderline (BB) leprosy were included in the study. Cross-sectional area (CSA) of ulnar nerve was measured every two centimeters from wrist to medial epicondyle and from there to axilla. All patients underwent standard motor and sensory nerve conduction studies of the ulnar nerve. Thirty age and sex matched controls underwent similar ulnar nerve CSA measurements and conduction studies. Ulnar nerve was clinically palpable in 19 of the 30 arms of patients. Motor and sensory nerve conduction studies of the ulnar nerve showed a reduced compound motor action potential and sensory nerve action potential amplitude in all patients. Motor Conduction Velocity (MCV) in patients were slower in comparison to controls, especially at the elbow and upper arm, but unable to exactly locate the site of the lesion. In comparison to controls the ulnar nerveCSA was larger in the whole arm in patients and quite specific the maximum enlargement was seen between nulnar sulcus and axilla, peaking at four centimeters above the sulcus. A unique sonographic pattern of nerve enlargement is noted in patients with ulnar neuropathy due to Hansen's disease, while this was not the case for the technique used until now, the electrodiagnostic testing. The enlargement starts at ulnar sulcus and is maximum four centimeters above the medial epicondyle and starts reducing further along the tract. This characteristic finding can help especially in diagnosing pure neuritic type of Hansen's disease, in which skin lesions are absent, and alsoto differentiate leprosy from other

  10. Hansen's disease control in the State of São Paulo: a historical analysis.

    Science.gov (United States)

    Opromolla, Paula Araujo; Laurenti, Ruy

    2011-02-01

    Leprosy is an infectious contagious disease known since Biblical times. Global effort for disease control reveals intricate convergences of national history and of medical, governmental, and international policies. The study describes the history of Hansen's disease and control actions undertaken in the state of São Paulo starting in the 19th century and its connection with the development of public health in that state, by means of a bibliographic and documental analysis.

  11. Solution of macromodels with Hansen-Sargent robust policies: Summary and some extensions

    OpenAIRE

    Giordani, Paolo; Söderlind, Paul

    2002-01-01

    We summarize some methods useful in formulating and solving Hansen-Sargent robust control problems, and suggest extensions to discretion and simple rules. Matlab, Octave, and Gauss software is provided. We illustrate these extensions with applications to the term structure of interest rates, the time inconsistency of optimal monetary policy, the effects of expectations on the variances of inflation and output, and on whether central banks should make their forecasts public.

  12. Solution of Macromodels with Hansen-Sargent Robust Policies: Some Extensions

    OpenAIRE

    Giordani, Paolo; Söderlind, Paul

    2004-01-01

    We summarize some methods useful in formulating and solving Hansen-Sargent robust control problems, and suggest extensions to discretion and simple rules. Matlab, Octave, and Gauss software is provided. We illustrate these extensions with applications to the term structure of interest rates, the time inconsistency of optimal monetary policy, the effects of expectations on the variances of inflation and output, and on whether central banks should make their forecasts public.

  13. A Modified Hansen's Theory as Applied to the Motion of Artificial Satellites

    Science.gov (United States)

    Musen, Peter

    1960-01-01

    This report presents a theory of oblateness perturbations of the orbits of artificial satellites based on Hansen's theory, with modification for adaptation to fast machine computation. The theory permits the easy inclusion of any gravitational terms and is suitable for the deduction of geo-physical and geodetic data from orbit observations on artificial satellites. The computations can be carried out to any desired order compatible with the accuracy of the geodetic parameters.

  14. Organogel formation rationalized by Hansen solubility parameters: dos and don'ts

    OpenAIRE

    Bonnet, Julien; Suissa, Gad; Raynal, Matthieu; Bouteiller, Laurent

    2014-01-01

    International audience; Some organic compounds gelate liquids by forming a network of anisotropic fibres. Hansen solubility parameters can be used to predict the range of liquids that are likely to be gelled by any given gelator. We critically review the various approaches recently proposed in the literature. In particular, we discuss the shape of the gelation domain, the relevance of the Teas plot representation and the use of group contribution calculations. We also propose an improved sche...

  15. Linfoma não Hodgkin simulando hanseníase virchowiana

    OpenAIRE

    Rocha Vanessa Barreto; Carvalho Saôny Victor de; Araújo Marcelo Grossi; Guedes Antônio Carlos Martins

    2003-01-01

    Os autores relatam caso de linfoma não Hodgkin em paciente do sexo feminino, de 28 anos, ressaltando o diagnóstico diferencial com formas multibacilares de hanseníase. Além de achados clínicos passíveis de confusão, a histologia mostrava, de modo não usual, infiltrado inflamatório mononuclear perineural e perianexial.

  16. Sleep, Hansen's disease and the immune system--a not so harmonic triad.

    Science.gov (United States)

    Albuquerque, Rachel Gimenes; Okazaki, Keity Mey; Hirotsu, Camila; Tomimori, Jane; Tufik, Sergio; Andersen, Monica Levy

    2015-05-01

    Hansen's disease is one of the oldest skin diseases in the world characterized by a spectrum of clinical manifestations that are associated with stigmatization and poor quality of life. It is also considered a model disease for investigating the human immune system because of its association with immune reactions, which are thought to be a reflection of the host's immunological response, promoting intense cellular activity or humoral secretion. This relationship between the cellular and microbial components of skin and their regulation by local immune responses may be modulated by a currently neglected behavior: sleep. Recent studies have demonstrated that sleep deprivation may aggravate the progression of chronic dermatological diseases, which in turn can lead to a non-restorative sleep pattern. Indeed, sleep is essential for immune and skin integrity. Thus, we propose here a hypothesis linking Hansen's disease, sleep and immunity in a bidirectional relationship. Hansen's disease patients may demonstrate a worse sleep quality than the general population through the modulation of immunological environment; and sleep restriction, a hallmark of modern society, being a possible predictor of the disease progression. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Optimization of subcritical fluid extraction of bioactive compounds using Hansen solubility parameters.

    Science.gov (United States)

    Srinivas, K; King, J W; Monrad, J K; Howard, L R; Hansen, C M

    2009-08-01

    Process engineering operations in food and nutraceutical industries pertaining to the design of extraction of value-added products from biomass using pressurized liquids involve a careful selection of the solvent and optimal temperature conditions to achieve maximum yield. Complex molecular structure and limited physical property data in the literature of biological solutes extracted from biomass compounds have necessitated the process modeling of such operations. In this study, we have applied the Hansen 3-dimensional solubility parameter concept to optimize the extraction of molecularly complex solutes using subcritical fluid solvents. Hansen solubility spheres characterized by the relative energy differences (RED) have been used to characterize and quantify the solute-subcritical solvent interactions as a function of temperature. The solvent power of subcritical water and compressed hydroethanolic mixtures above their boiling points has been characterized using the above-mentioned method. The use of group contribution methods in collaboration with computerized algorithms to plot the Hansen spheres provides a quantitative prediction tool for optimizing the design of extraction conditions. The method can be used to estimate conditions for solute-solvent miscibility, an optimum temperature range for conducting extractions under pressurized conditions, and approximate extraction conditions of solutes from natural matrices.

  18. A Quantum Mermin-Wagner Theorem for a Generalized Hubbard Model

    Directory of Open Access Journals (Sweden)

    Mark Kelbert

    2013-01-01

    Full Text Available This paper is the second in a series of papers considering symmetry properties of bosonic quantum systems over 2D graphs, with continuous spins, in the spirit of the Mermin-Wagner theorem. In the model considered here the phase space of a single spin is ℋ1=L2(M, where M is a d-dimensional unit torus M=ℝd/ℤd with a flat metric. The phase space of k spins is ℋk=L2sym(Mk, the subspace of L2(Mk formed by functions symmetric under the permutations of the arguments. The Fock space H=⊕k=0,1,…ℋk yields the phase space of a system of a varying (but finite number of particles. We associate a space H≃H(i with each vertex i∈Γ of a graph (Γ,ℰ satisfying a special bidimensionality property. (Physically, vertex i represents a heavy “atom” or “ion” that does not move but attracts a number of “light” particles. The kinetic energy part of the Hamiltonian includes (i -Δ/2, the minus a half of the Laplace operator on M, responsible for the motion of a particle while “trapped” by a given atom, and (ii an integral term describing possible “jumps” where a particle may join another atom. The potential part is an operator of multiplication by a function (the potential energy of a classical configuration which is a sum of (a one-body potentials U(1(x, x∈M, describing a field generated by a heavy atom, (b two-body potentials U(2(x,y, x,y∈M, showing the interaction between pairs of particles belonging to the same atom, and (c two-body potentials V(x,y, x,y∈M, scaled along the graph distance d(i,j between vertices i,j∈Γ, which gives the interaction between particles belonging to different atoms. The system under consideration can be considered as a generalized (bosonic Hubbard model. We assume that a connected Lie group G acts on M, represented by a Euclidean space or torus of dimension d'≤d, preserving the metric and the volume in M. Furthermore, we suppose that the potentials U(1, U(2, and V are G-invariant. The result

  19. [Social rehabilitation experiences of people with a history of Hansen's disease: interviews of readmitted residents in a sanatorium].

    Science.gov (United States)

    Sashida, Momoe; Nagata, Satoko; Murashima, Sachiyo; Haruna, Megumi

    2005-02-01

    This study focused on the reflections of people with a history of Hansen's disease who once experienced social life and then returned to their sanatorium again. The purpose was to clarify what they think about their experiences of social life outside of institutions. Study participants were people with a history of Hansen's disease who had experienced social life outside of the sanatorium and are now living in a national sanatorium with good ADL. The study was based on a semi-structured interview, the data being categorized with the focus on "situations or topics affect by Hansen's disease". Thirteen people agreed to participate in the study. Six categories were abstracted: "maintaining a good condition," "anxiety about relapse or illness," "medical service," "coping with Hansen's disease in social life," "relationships with others," and "means of livelihood." Hansen's disease affected their lives in 2 aspects; one was "sawagu (recurrence of the disease)" and the other "kakusu (concealing the disease)." "Sawagu" was related to "anxiety of the disease" and "intention of maintaining a good condition." "Kakusu" affected the way of "coping with the disease in social life" and "the relationship with others." "Medical service" was important for both "sawagu" and "kakusu." Patients were visiting hospitals and taking medicine to avoid "sawagu," while trying to "kakusu" when they consulted with physicians. Similarly, both "sawagu" and "kakusu" interacted with each other when the participants needed to work and earn a living. All participants looked back at their social life as a "good experience" because they were satisfied with the sense of accomplishment or fulfillment the experience had given them. Participants of the study looked back at their social life as a "good experience." Hansen's disease affected their social life in 2 aspects; "sawagu" and "kakusu." It is necessary to alleviate difficulties with both of these so that people with stigmatized disease such as

  20. Evaluating the Reliability and Reproducibility of the AO and Lauge-Hansen Classification Systems for Ankle Injuries.

    Science.gov (United States)

    Yin, Meng-Chen; Yuan, Xue-Fei; Ma, Jun-Ming; Xia, Ye; Wang, Tao; Xu, Xiao-Li; Yan, Yin-Jie; Xu, Jin-Hai; Ye, Jie; Tong, Zheng-Yi; Feng, Yan-Qi; Wang, Hong-Bo; Wu, Xue-Qun; Mo, Wen

    2015-07-01

    Ankle injuries are responsible for more than 5 million emergency department visits each year. The AO and Lauge-Hansen classification systems are widely used in the clinical diagnosis of ankle injuries. This study aimed to analyze the intraobserver reliability and interobserver reproducibility of the AO and Lauge-Hansen classification systems. In addition, the authors explored the differences among physicians' classification responses and evaluated the clinical value for diagnosis. Fifty-six patients with an ankle injury with complete clinical and radiologic data were enrolled. The definition of injury type, the index score typing methods, and the specific study criteria were explained in detail. Five observers, who were orthopedic surgeons, determined the classifications according to both the AO and Lauge-Hansen systems. The classification was repeated 1 month later. Cronbach's alpha and Cohen's kappa test were used to determine interobserver reliability and intraobserver reproducibility. The physicians conducted 560 classifications (56 cases × 5 physicians × 2 times per patient). Average inter- and intraobserver kappa values for the AO system were 0.708 and 0.608, respectively. Average inter- and intraobserver kappa values for the Lauge-Hansen system were 0.402 and 0.398, respectively. Cronbach's alpha coefficient was 96.7% for the AO system and 76.0% for the Lauge-Hansen system. The Lauge-Hansen classification system is a comprehensive yet cumbersome system. Comparatively, the AO classification system is easier to understand. This study shows that the AO classification system has more reliability and reproducibility, and thus has more value in clinical practice, than the Lauge-Hansen classification system.

  1. A geometria fractal da rede de drenagem da bacia hidrográfica do Caeté, Alfredo Wagner-SC Fractal geometry of the drainage network of the Caeté river watershed, Alfredo Wagner-SC

    Directory of Open Access Journals (Sweden)

    Leandro Redin Vestena

    2010-08-01

    Full Text Available Os objetivos deste trabalho foram estimar e avaliar a dimensão fractal da rede de drenagem da bacia hidrográfica do Caeté, em Alfredo Wagner, SC, a partir de diferentes métodos, com o propósito de caracterizar as formas geomorfológicas irregulares. A rede de drenagem apresenta propriedades multifractais. As dimensões fractais para os segmentos individuais (df e para a rede de drenagem inteira (Df foram determinadas por métodos que se fundamentaram nas razões de Horton e pelo método da contagem de caixas (Box-Counting. A rede de drenagem tem característica de autoafinidade. A dimensão fractal proveniente da relação de parâmetros obtidos pelas Leis de Horton apresentou resultados dentro dos limiares da teoria da geometria fractal.The objective of the present work was to evaluate the fractal dimensions of the drainage network of the Caeté river watershed, Alfredo Wagner/SC, with different methods in order to characterize the irregular geomorphologic forms. The drainage network possesses multi-fractal properties. That is why the fractal dimensions for the individual segments (df and for the entire network (Df were evaluated with Horton's Laws and the Box-Counting method. The drainage network has self-affinity characteristics. The fractal dimension obtained through the parameters relationship of Horton's Laws showed the results within the thresholds of the fractal geometry theory.

  2. Relationship between swelling of hydroxypropylmethylcellulose and the Hansen and Karger partial solubility parameters.

    Science.gov (United States)

    Navarro-Lupión, Francisco-Javier; Bustamante, Pilar; Escalera, Begoña

    2005-07-01

    A model that relates the equilibrium swelling of hydroxypropylmethylcellulose to the partial solubility parameters of both the polymer and the solvents is proposed to interpret and correlate the experimental data. The non-specific interactions are expressed as the dispersion delta(d) and polar delta(p) solubility parameters of Hansen, or as a combination of both. Hydrogen bonding is represented by the acidic delta(a) and the basic delta(b) Karger solubility parameters. The results are compared with models including the same parameters for non-specific interactions (delta(d) and delta(p)) and the Hansen hydrogen bonding parameter delta(h). Equilibrium swelling of this hydrophilic polymer that is widely used in drug formulation is measured in pure solvents covering a wide polarity range. In a qualitative way, swelling increases in solvents with higher Hildebrand solubility parameters and stronger hydrogen bonding capability, and it decreases in non-polar solvents. Single polarity indexes, such as the Hildebrand solubility parameter or the partition coefficient (PC), do not fit well the overall experimental data. The best correlations were obtained with the proposed model, providing at the same time an interpretation consistent with the physical meaning of the terms included in the equation. Swelling increases as the non-specific interactions of the polymer and the solvents become alike, and as the Lewis acid-base interactions of the polymer (1) and the solvent (2) represented by the products delta(1a)delta(2b) and delta(1b)delta(2a) become greater. Conversely, hydrogen bonding self association of the solvents (the product delta(1a)delta(1b)) lowers swelling. The results show that the Karger hydrogen bonding parameters provide a better approach than the Hansen hydrogen bonding parameter to correlate the swelling behavior of a hydrophilic polymer. (c) 2005 Wiley-Liss, Inc.

  3. Isolamento compulsório de portadores de hanseníase: memória de idosos The compulsory isolation of Hansen's disease patients: memories of the elderly

    Directory of Open Access Journals (Sweden)

    Selma Munhoz Sanches de Castro

    2009-06-01

    Full Text Available De 1924 a 1962 o Brasil utilizou a internação compulsória de pacientes de hanseníase como controle da doença na comunidade. Com o final dessa política, muitos pacientes continuaram a viver nessas unidades. O Asilo Pirapitingui, hoje Hospital Dr. Francisco Ribeiro Arantes, é a única retaguarda asilar para internação de portadores de hanseníase por indicação social. Obtivemos o relato da história de vida de oito de seus remanescentes, que foram gravados e transcritos. A análise temática desses relatos permitiu a identificação das seguintes categorias: hanseníase; internação; vida cotidiana; a instituição; condições atuais de saúde; e permanência na instituição após a extinção da internação compulsória.From 1924 to 1962, Brazil used compulsory internment of Hansen's disease patients as one of the ways of controlling the disease in the community. After this policy ended, many patients continued to live in these units. The former Asilo Pirapitingui, now the Hospital Dr. Francisco Ribeiro Arantes, is the only old-style asylum for the socially determined internment of those suffering from Hansen's disease. Through recorded and transcribed interviews of eight of those remaining, we sought to learn their history and the meaning of this isolation in their lives. The thematic analysis of the discourse enabled identification of the following analysis categories: Hansen's disease; internment; day-to-day life; the institution; current health conditions; and staying in the institution after the end of compulsory internment.

  4. Primary Neuritic Hansen's Disease presenting as Ulnar Nerve Abscess in a Human Immunodeficiency Virus Positive Patient.

    Science.gov (United States)

    Karjigi, S; Herakal, K; Murthy, S C; Bathina, A; Kusuma, M R; Nikhil, K R Y

    2015-01-01

    Leprosy has been increasingly known to have an enigmatic relationship with human immunodeficiency virus infection. Co-infection may result in atypical manifestations of leprosy. A 45-year old human immunodeficiency virus-positive male; agricultural laborer presented with a swelling over right elbow, right hand deformity, generalized itching and recurrent vesicles overthe perinasal area. Clinical and investigational findings were consistent with mononeuritic type of Hansen's disease with right sided silent ulnar nerve abscess, partial claw hand. CD4+ count of the patientwas 430 cells/cmm. This patient also hadherpes simplex labialis, with HIV-associated pruritus. To the best of our knowledge such an atypical presentation has not been reported earlier.

  5. Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease.

    Science.gov (United States)

    Okonta, Patrick I; Mofon, Chukwuemeke

    2014-01-01

    Mature ovarian cystic teratomas are common benign ovarian neoplasm derived from germ cells. With increasing availability of ultrasound services even in developing countries, the diagnosis of benign ovarian tumour is made earlier and the size of the ovarian tumour at diagnosis is relatively small. It is unusual to find an ovarian cystic teratoma larger than 10 cm. We report a huge mature ovarian cystic teratoma in a multipara with a history of Hansen's disease. We conclude that, in circumstances where women have restricted access to health care, the unusual finding of mature ovarian cystic teratoma larger than 10 cm is possible due to delayed presentation for diagnosis and treatment.

  6. The effect of different initial density onAmphidinium carterae Hulburt and Kreniamikimotoi Hansen

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    The experimental study of the interaction between Amphidinium carterae Hulburt and Krenia mikim otoi Hansen is carried in ecologicalconditions.. The results showed tha in single culture system, A.carterae and K.mikimotoi growth curves Karen Logistic growth model, different initial densityratio could have a significant impact on the growth of two microalgae : With the initial density increases, the exponential phase and stationary phase is due to comeearlier, and instantaneous population growth rate (r) and environmental carrying capacity (K) decreased.

  7. First order post-Newtonian gravitational waveforms of binaries on eccentric orbits with Hansen coefficients

    Science.gov (United States)

    Mikóczi, Balázs; Forgács, Péter; Vasúth, Mátyás

    2015-08-01

    The inspiral and merger of supermassive black hole binary systems with high orbital eccentricity are among the promising sources of the advanced gravitational wave observatories. In this paper we compute gravitational waveforms in the frequency domain to the first post-Newtonian order, emitted by compact binary systems with arbitrary eccentricity. Our results are fully analytic, ready-to-use expressions of the waveforms in terms of a suitable generalization of Hansen coefficients known from celestial mechanics. Secular terms induced by the eccentricity are eliminated by introducing a suitable phase shift. The obtained waveforms have a rather simple structure, greatly facilitating their use in applications.

  8. Morphologies in Solvent-Annealed Clotrimazole Thin Films Explained by Hansen-Solubility Parameters.

    Science.gov (United States)

    Ehmann, Heike M A; Zimmer, Andreas; Roblegg, Eva; Werzer, Oliver

    2014-03-05

    The induction of different crystal morphologies is of crucial importance for many applications. In this work, the preparation of various crystal morphologies within clotrimazole films on glass substrates is demonstrated. Amorphous clotrimazole thin films were transformed via vapor annealing into crystalline structures; highly monodisperse/multidisperse crystallites, spherulite, or dendritic structures were obtained as the solvent was exchanged. X-ray diffraction experiments reveal that the same polymorph is present for all samples but with varying texture. The achieved morphologies are explained in terms of Hansen-solubility parameters and vapor pressures; thus, the different morphologies and crystal orientations can be explained by solvent-solid interaction strengths within the thin film samples.

  9. Effect of Surface Modification on the Hansen Solubility Parameters of Single-Walled Carbon Nanotubes

    DEFF Research Database (Denmark)

    Ma, Jing; Larsen, Mikael

    2013-01-01

    In this work, seven types of surface-modified single-walled carbon nanotubes (SWNTs) were studied by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy to investigate the functional groups and extent of functionalization. Hansen solubility parameters were determined based on observations...... of the sedimentation and swollen states of the SWNTs in solvents after ultrasonication, and the results were compared with the hydrodynamic sizes of the SWNTs evaluated by the dynamic light scattering method. We found that the solubility of SWNTs is related to their functional groups and degree of functionalization...

  10. Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy.

    Science.gov (United States)

    Veiga, Andreia; Costa, Alexandre; Taipa, Ricardo; Guimarães, António; Pires, Manuel Melo

    2015-01-01

    Introdução: A lepra continua a ser uma das causas mais frequentes de neuropatia periférica. Apesar de tida como erradicada em Portugal, ainda se documenta no estudo neuropatológico de doentes com clínica de neuropatia periférica sem diagnóstico etiológico definido.Material e Métodos: Revisão dos casos neuropatia por doença de Hansen diagnosticados na Unidade de Neuropatologia do Centro Hospitalar do Porto no período de 1978 e 2013 atendendo ao género, idade, manifestações clínicas e achados neuropatológicos.Resultados: Foram identificados 21 doentes com diagnóstico neuropatológico de neuropatia por doença de Hansen, com predomínio do sexo masculino. A idade média ao diagnóstico foi de 52 anos, sendo a sintomatologia sensitiva predominante. O intervalo entre sintomatologia e diagnóstico oscilou entre 1 a 38 anos. Na maioria foi identificada forma tuberculoide em biópsia de nervo e detetados bacilos em pele e nervo em 44% dos casos.Discussão: A mononeurite é a forma mais comum de apresentação de hanseníase, podendo cursar com outras manifestações clínicas incluindo lesões cutâneas. A infeção pelo M. leprae lesiona fibras mielinizadas e não mielinizadas, com substituição do tecido nervoso por colagénio resultando em fibrose. O diagnóstico da lepra é apenas conseguido por estudo neuropatológico das lesões cutâneas e/ou nervo periférico, adjuvado pela identificação do bacilo.Conclusão: A doença de Hansen continua a ser um problema de saúde pública em áreas tropicais e, apesar de rara, ainda descrita em países ocidentais, devendo ser considerada como uma hipótese de diagnóstico na investigação de neuropatia periférica.

  11. Isometry group and geodesics of the Wagner lift of a riemannian metric on two-dimensional manifold

    CERN Document Server

    B., José Ricardo Arteaga

    2010-01-01

    In this paper we construct a functor from the category of two-dimensional Riemannian manifolds to the category of three-dimensional manifolds with generalized metric tensors. For each two-dimensional oriented Riemannian manifold $(M,g)$ we construct a metric tensor $\\hat g$ (in general, with singularities) on the total space $SO(M,g)$ of the principal bundle of the positively oriented orthonormal frames on $M$. We call the metric $\\hat g$ the Wagner lift of $g$. We study the relation between the isometry groups of $(M,g)$ and $(SO(M,g),\\hat g)$. We prove that the projections of the geodesics of $(SO(M,g),\\hat g)$ onto $M$ are the curves which satisfy the equation \\begin{equation*} \

  12. Maxwell-Wagner-Sillars effects on the thermal-transport properties of polymer-dispersed liquid crystals

    Science.gov (United States)

    Kuriakose, M.; Longuemart, S.; Depriester, M.; Delenclos, S.; Sahraoui, A. Hadj

    2014-02-01

    We present the depolarization field effects (Maxwell-Wagner-Sillars effect) for the thermal transport properties of polymer dispersed liquid crystal composites under a frequency-dependent electric field. The experiments were conducted on polystyrene/4-Cyano-4'-pentylbiphenyl (PS/5CB) PDLCs of 73 vol.% and 85 vol.% liquid crystal (LC) concentrations. A self-consistent field approximation model is used to deduce the electrical properties of polymer and LC materials as well as the threshold electric field. Electric field-varying (at constant frequency) experiments were also conducted to calculate the interfacial thermal resistance between the LC droplets and polymer matrix as well as to find the elastic constant of LCs in droplet form.

  13. Olfactory response of predatory Macrolophus caliginosus Wagner (Heteroptera: Miridae) to the odours host plant infested by Bemisia tabaci

    Science.gov (United States)

    Saad, Khalid A.; Roff, M. N. Mohamad; Salam, Mansour; Hanifah Mohd, Y.; Idris, A. B.

    2014-09-01

    Plant infested with herbivores, release volatile that can be used by natural enemies to locate their herbivorous prey. Laboratory studies were carried out to determine the olfactory responses of predator Macrolophus caliginosus Wagner (Heteroptera: Miridae), to chili plant infected with eggs, nymphs of Bemisia tabaci, using Y-tube olfactometer. The results shown that predator, M. caliginosus has ability to discriminate between non-infested and infested plant by B. tabaci. Moreover, the predator preferred plants with nymphs over plants with eggs. This suggested that M. caliginous uses whitefly-induced volatile as reliable indicators to distinguish between infested chili plants by nymphs, eggs and non-infested plants. These results enhance our understanding of the olfactory cues that guide foraging by M. caliginosus to plant with and without Bemisia tabaci.

  14. Modèle de diélectrique associant les effets Poole-Frenkel et Maxwell-Wagner

    OpenAIRE

    1992-01-01

    Le modèle présenté associe les effets Poole-Frenkel (PF) et Maxwell-Wagner (MW) dans la détermination de la conductivité équivalente σ d'un diélectrique plan à deux couches. L'effet PF y est introduit sous sa forme usuelle (statistique de Boltzmann), puis sous une forme plus générale (statistique de Fermi-Dirac). Les courbes log σ en fonction du champ électrique $(\\sqrt{F})$ présentent généralement une ou deux parties linéaires, la pente en bas champs étant toujours supérieure à la pente en h...

  15. [Study of ocular fungal microbiota in patients with Hansen's disease and in individuals who deal with them].

    Science.gov (United States)

    Santos, Procópio Miguel dos; Melo, Cinthia Mendonça de; Martins, Suy Anne Rebouças; Chaves, Adriano de Almeida; Sá, Débora Silva Pires de; Santos, Regina Cândido Ribeiro dos

    2006-01-01

    To study the conjunctival fungal flora of patients with leprosy who live in the colony hospital and of those who deal with "Hansen" patients. Sixty-one eyes (61 patients) with Hansen's disease and twenty-five healthy eyes (25 individuals) of individuals who deal with patients were investigated. Conjunctival fungi growth occurred in 19.67% and 20% of the patients and healthy individuals, respectively. There was no significant difference (p<0.05) regarding fungi percentage of fungi isolated from the conjunctiva between both groups. Candida ssp was the most frequent fungus isolated from the conjunctiva of patients with Hansen's disease, whereas Penicillium spp was the most frequent fungus isolated from the group of people who deal with these patients. The most frequent yeast isolated from conjunctival samples of leprosy patients was Candida, which could be explained by cellular immunodeficiency of these patients, associated with dry eye and the prolonged use of antibiotics.

  16. Glosas marginais ao “Tratado de Economia Política” de Adolfo Wagner - Karl Marx

    Directory of Open Access Journals (Sweden)

    Evaristo Emigdo Colman

    2011-12-01

    Full Text Available   Estas glosas marginais são o último trabalho econômico de Marx. foram encontradas num caderno de extratos de leituras dos anos 1881-82 intitulado “Coisas econômicas em geral (X”. As glosas que publicamos aqui são uma seleção traduzida da edição de O Capital preparada e publicada pelo “Instituto Marx-Engels-Lênin” de Moscou (Verlag für Literatur und Politik, Viena-Berlin, pp. 841-853 (Apêndice. Para facilitar a compreensão destas glosas (que não foram redigidas por Marx para serem publicadas, pois, se trata só de notas-comentários de leituras, os redatores alemães desta edição interpolaram no texto algumas palavras esclarecedoras, entre colchetes. Também da mesma edição alemã foram tomadas as notas que aqui figuram com a indicação (Ed.. O título exato do livro à que se referem as glosas de Marx é: Adolf Wagner, Allgemeine oder theoretische Volkswirstschaftslehre, Ester Teil. Grundlegung. Grundlagen der Volkswirstschaft Volkswirstschaft und Recht, besonders Vermörensrecht. Segunda edição notavelmente corrigida e aumentada, Liepzig e Heldberg, 1879. Publicado como o Tomo I do Lehrbuch der politischen Oekonomic in einzelnen selsbständugen Abteilungen, reed. por A. Wagner e E. Natze. (Ed..  

  17. 20 CFR 661.240 - How do the unified planning requirements apply to the five-year strategic WIA and Wagner-Peyser...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How do the unified planning requirements apply to the five-year strategic WIA and Wagner-Peyser plan and to other Department of Labor plans? 661... ACT State Governance Provisions § 661.240 How do the unified planning requirements apply to the...

  18. A new species of the stilt bug genus Gampsocoris from Senegal and a new generic combination for Gampsocoris gomeranus Wagner (Heteroptera: Berytidae: Gampsocorinae)

    Science.gov (United States)

    The relationships the African gampsocorine (Gampsocorinae) genera Gampsoacantha Josifov and Štusak, Gampsocoris Fuss, and Micrometacanthus are discussed. Gampsocoris gomeranus Wagner, having a median anterior spine, three basal processes on the pronotum, and a short, round antennal segment IV, is t...

  19. Gerhard Henrik Armauer Hansen (1841-1912)--the 100th anniversary of the death of the discoverer of Mycobacterium leprae.

    Science.gov (United States)

    Grzybowski, Andrzej; Sak, Jarosław; Pawlikowski, Jakub; Iwanowicz-Palus, Grażyna

    2013-01-01

    The year 2012 marked the 100th anniversary of the death of Gerhard Henrik Armauer Hansen (1841-1912), a Norwegian physician known for his identification of Mycobacterium leprae as the causative agent of leprosy. In the second half of the 19th century, the medical community believed leprosy had a noninfectious etiology, and it was not until Hansen uncovered the relationship between M leprae and the clinical manifestations of this disease did that belief begin to change. Strengthening of the late 19th and early 20th century beliefs of the infectious etiology of leprosy made it possible to develop an effective treatment for this still terrible disease.

  20. Depression impacts prognosis of the patients with Wagner grades 3 diabetic foot ulcers%抑郁情绪对Wagner3级糖尿病足溃疡住院患者预后的影响

    Institute of Scientific and Technical Information of China (English)

    刘倩; 李代清; 柳雷; 孙茜; 杨蔚; 张达; 褚月颉; 王鹏华

    2013-01-01

    Objective To evaluate the impact of depression on prognosis of Wagner grade 3 diabetic foot ulcer patients by a psychological assessment.Methods One hundred and sixty-eight patients suffered from Wagner grade 3 diabetic foot ulcers hospitalized in the Tianjin Metabolic Diseases Hospital from June 2010 to May 2011 were included in the study.Their psychological disorders were evaluated by a self-rating depression scale (SDS) to identify depression.Patients complicated with depression or not were divided into two groups accordingly.Unhealing rate and amputation risk of the patients in the two groups were compared using Chi-square test and logistic regression,respectively.Results Ninety-five out of 168 patients (56.5%) were identified as depression and the others (73 out of 168,43.5%) were not.The unhealing rate of the patients complicated with depression was significantly higher than that of the patients without depression analyzed by Chi-square test (18.9% and 6.8% respectively,OR =2.779,95% CI:1.120-9.023).Logistic regression analysis indicated that depression was a risk factor of unhealed ulcers (OR =3.569,95% CI:1.220-10.442) after the factors related to prognosis of diabetic foot ulcer were adjusted step-by-step,including infection,arterial disease,age,glycosylated hemoglobin A1e and Charlson grading of complications.Healed patients were further analyzed by logistic regression analysis.Healing after amputation rate is higher among the patients complicated with depression than that of the patients without depression after the adjustment mentioned above (OR =2.793,95% CI:1.361-5.732).Conclusion Depression is common among patients with Wagner grade 3 diabetic foot ulcers and has adverse effects on the prognosis of the patients.It implies that identification of depressed should be a routine process for diabetic foot ulcer patients to improve wound healing and reduce amputation rate.%目的 通过对糖尿病足溃疡住院患者进行心理评估,探

  1. Adesão ao tratamento da Hanseníase: dificuldades inerentes aos portadores

    Directory of Open Access Journals (Sweden)

    Izaildo Tavares Luna

    2010-12-01

    Full Text Available Esta pesquisa, realizada em Guaiúba, CE, Brasil, objetivou identificar as dificuldades de adesão ao tratamento pelos portadores de hanseníase, relacionando os fatores associados. Estudo qualitativo, cujos dados foram coletados a partir de uma visita domiciliária com roteiro de entrevista contendo sete questões norteadoras. Participaram pacientes com diagnóstico de hanseníase e histórico de não adesão ao tratamento. Utilizou-se o Modelo de Atividade de Vida de Roper, Logan e Tierney. As falas dos sujeitos foram categorizadas de acordo com as doze atividades de vida. A utilização do modelo possibilitou uma abordagem holística sobre as barreiras vivenciadas pelo hanseniano na adesão ao tratamento medicamentoso, de modo a conhecer as atividades de vida destes pacientes para possível adequação de ações voltadas a essa clientela.

  2. Dorsal sensory impairment in hands and feet of people affected by Hansen's disease in Israel.

    Science.gov (United States)

    Wexler, Ruth; Melchior, Hanna

    2007-12-01

    Sensory testing in people affected by Hansen's disease is usually performed on palms and soles only. In Israel, both palmar/plantar and dorsal aspects of limbs are routinely tested. The aim of this study was to describe the magnitude of dorsal sensory impairment (SI) in limbs and compare the frequency of SI on palms and soles with that on the dorsum of hands and feet. In a cross-sectional study, limbs of 140 patients registered at The Israel Hansen's Disease Centre during the years 1999-2003 were tested for their sensory status. Both palmar/plantar and dorsal aspects were tested using Semmes-Weinstein monofilaments. SI was defined as not feeling stimuli applied with the 2 g monofilament. SI was detected on the dorsum in 43% of sites on hands and only in 27% on palms. 64% of sites on dorsum of feet had SI compared to 53% on the soles. SI was detected in up to 18% in hands with no palmar SI, and in 6% of feet with no plantar SI. Furthermore, SI on palms and soles was found to be accompanied by dorsal SI in all hands and in 97% of feet. SI on dorsum of limbs occurs more frequently than SI on palms and soles. Therefore sensory testing should also consider inclusion of the dorsal aspect of hands and feet.

  3. Hildebrand and Hansen solubility parameters from molecular dynamics with applications to electronic nose polymer sensors.

    Science.gov (United States)

    Belmares, M; Blanco, M; Goddard, W A; Ross, R B; Caldwell, G; Chou, S-H; Pham, J; Olofson, P M; Thomas, Cristina

    2004-11-30

    We introduce the Cohesive Energy Density (CED) method, a multiple sampling Molecular Dynamics computer simulation procedure that may offer higher consistency in the estimation of Hildebrand and Hansen solubility parameters. The use of a multiple sampling technique, combined with a simple but consistent molecular force field and quantum mechanically determined atomic charges, allows for the precise determination of solubility parameters in a systematic way (sigma = 0.4 hildebrands). The CED method yields first-principles Hildebrand parameter predictions in good agreement with experiment [root-mean-square (rms) = 1.1 hildebrands]. We apply the CED method to model the Caltech electronic nose, an array of 20 polymer sensors. Sensors are built with conducting leads connected through thin-film polymers loaded with carbon black. Odorant detection relies on a change in electric resistivity of the polymer film as function of the amount of swelling caused by the odorant compound. The amount of swelling depends upon the chemical composition of the polymer and the odorant molecule. The pattern is unique, and unambiguously identifies the compound. Experimentally determined changes in relative resistivity of seven polymer sensors upon exposure to 24 solvent vapors were modeled with the CED estimated Hansen solubility components. Predictions of polymer sensor responses result in Pearson R2 coefficients between 0.82 and 0.99.

  4. Perspectivas da participação dos hospitais gerais na assistência aos doentes de hanseníase A general outlook as to the participation of general hospital's regarding attention to patients with Hansen's disease

    Directory of Open Access Journals (Sweden)

    Cid Guimarães

    1975-09-01

    Full Text Available Uma síntese histórica demonstra que o hospital tem voltado sua assistência para os aspectos da medicina curativa, para o que muito têm contribuído os progressos de diagnóstico e terapêutica. Os lazaretos e sua versão posterior, os hospitais de isolamento, por sua vez, colaboraram para que o hospital geral se mantivesse afastado, até recentemente, da assistência às doenças infecto-contagiosas e até o presente, ao mal de Hansen, sendo referidas as exceções de hospitais escolas de São Paulo. É destacada a importância da educação do corpo clínico, administração e pacientes dos hospitais, bem como do público em geral, como meio de tornar factível, a curto prazo, a integração da assistência dos portadores de hanseníase nos hospitais gerais. Como solução, é proposto o enfoque sistêmico, sendo ressaltado o valor da hanseníase ser considerada como componente normal da problemática geral de saúde e não como um aspecto isolado. As vantagens da adoção desse enfoque são apontadas, situando o hanseniano na multidão assistida pelos hospitais, de forma a torná-lo um paciente qualquer.A historical synthesis shows that the hospital has turned its attention towards the curative aspects of medicine. Diagnosis and therapeutic progress have much contributed towards this, in especial. The lazarets and their later version, the isolation hospitals, have helped in maintaining the general hospitals away, until very recently, from Hansen's disease. The medical school hospitals of São Paulo are exceptions. The importance of the education of the medical and administrative staff, the patients of the hospital, as well as the general public is stressed as being the only way of integrating assistance to the bearers of Hansen's disease in the general hospitals within a short period. A systematic approach is proposed as the solution, as Hansen's disease ought to be considered as a normal component of the general health programme. The

  5. Estudo da microbiota fúngica da conjuntiva ocular em portadores de hanseníase e seus comunicantes Study of ocular fungal microbiota in patients with Hansen's disease and in individuals who deal with them

    Directory of Open Access Journals (Sweden)

    Procópio Miguel dos Santos

    2006-12-01

    Full Text Available OBJETIVO: Investigar a microbiota fúngica de pacientes portadores de hanseníase residentes no hospital-colônia e seus comunicantes. MÉTODOS: Foram estudados por meio da cultura em meio de ágar-Saboraud-dextrose, o material do fórnice conjuntival, de sessenta e um pacientes portadores de hanseníase, residentes no hospital-colônia de Goiânia e 25 indivíduos que residiam ou trabalhavam com os referidos pacientes, no mínimo há cinco anos. RESULTADOS: Nos portadores de hanseníase foram isolados fungos da conjuntiva de 12 pacientes (19,67%, sendo o gênero Candida o mais isolado, e no grupo controle de 5 indivíduos (20%, em que o gênero mais isolado foi Penicillium spp. CONCLUSÃO: Candida foi o gênero predominante na flora conjuntival dos portadores de hanseníase: fato que poderia ser explicado pela imunodeficiência celular que estes pacientes apresentam, além do olho seco e uso prolongado de antibiótico.PURPOSE: To study the conjunctival fungal flora of patients with leprosy who live in the colony hospital and of those who deal with "Hansen" patients. METHODS: Sixty-one eyes (61 patiets with Hansen's disease and twenty-five heathy eyes (25 individuals of individuals who deal with patients were investigated. RESULTS: Conjunctival fungi growth occurred in 19.67% and 20% of the patients and healthy individuals, respectively. There was no significant difference (p<0.05 regarding fungi percentage of fungi isolated from the conjunctiva between both groups. Candida ssp was the most frequent fungus isolated from the conjunctiva of patients with Hansen's disease, whereas Penicillium spp was the most frequent fungus isolated from the group of people who deal with these patients. CONCLUSION: The most frequent yeast isolated from conjunctival samples of leprosy patients was Candida, which could be explained by cellular immunodeficiency of these patients, associated with dry eye and the prolonged use of antibiotics.

  6. Autologous Platelet-rich Fibrin Matrix in Non-healing Trophic Ulcers in Patients with Hansen's Disease.

    Science.gov (United States)

    Nagaraju, Umashankar; Sundar, Priya K; Agarwal, Priyanka; Raju, Belliappa P; Kumar, Mahesh

    2017-01-01

    Non-healing trophic ulcers in Hansen's disease patients is one of the major causes for disability. It has been shown that autologous platelet-rich fibrin matrix (PRFM) is effective in healing chronic non-healing leg ulcers. The objective of this study is to demonstrate the efficacy of autologous platelet-rich fibrin matrix (PRFM) in non-healing trophic ulcers in patients treated for Hansen's disease. A prospective study. An institution-based clinic. Seven treated patients with Hansen's disease, with a mean age of 38.33 years, with nine non-healing trophic ulcer of more than 6 weeks duration. Photographs were taken before treatment and at every subsequent sitting. Area and volume were calculated at baseline and every subsequent sitting till the closure was achieved. The healthy ulcers were treated with PRFM at weekly intervals, repeated once a week for a maximum of five sittings as per requirement. The mean percentage improvement in the area was 93.52%, and volume was 97.74% at the end of the second sitting. All ulcers closed by a maximum of five sittings. No adverse events were noted. PRFM for the treatment of trophic ulcers in treated patients with Hansen's disease is a feasible, safe, simple and inexpensive method.

  7. Autologous platelet-rich fibrin matrix in non-healing trophic ulcers in patients with Hansen's disease

    Directory of Open Access Journals (Sweden)

    Umashankar Nagaraju

    2017-01-01

    Full Text Available Background: Non-healing trophic ulcers in Hansen's disease patients is one of the major causes for disability. It has been shown that autologous platelet-rich fibrin matrix (PRFM is effective in healing chronic non-healing leg ulcers. Aim: The objective of this study is to demonstrate the efficacy of autologous platelet-rich fibrin matrix (PRFM in non-healing trophic ulcers in patients treated for Hansen's disease. Design: A prospective study. Setting: An institution-based clinic. Participants: Seven treated patients with Hansen's disease, with a mean age of 38.33 years, with nine non-healing trophic ulcer of more than 6 weeks duration. Measurements: Photographs were taken before treatment and at every subsequent sitting. Area and volume were calculated at baseline and every subsequent sitting till the closure was achieved. Materials and Methods: The healthy ulcers were treated with PRFM at weekly intervals, repeated once a week for a maximum of five sittings as per requirement. Results: The mean percentage improvement in the area was 93.52%, and volume was 97.74% at the end of the second sitting. All ulcers closed by a maximum of five sittings. No adverse events were noted. Conclusion: PRFM for the treatment of trophic ulcers in treated patients with Hansen's disease is a feasible, safe, simple and inexpensive method.

  8. The Trail Inventory of Julia Butler Hansen Refuge For The Columbian White-tailed Deer [Cycle 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Julia Butler Hansen Refuge for the Columbian White-Tailed Deer. Trails in...

  9. From Paris to Lyon, and from simple to complex liquids: a view on Jean-Pierre Hansen's contribution

    Science.gov (United States)

    Barrat, Jean-Louis; Biben, Thierry; Bocquet, Lydéric

    2015-09-01

    We present a short perspective on some of the contributions made by Jean-Pierre Hansen to our theoretical understanding of soft matter static structure and dynamics, using the tools developed for simple liquids within the rigorous framework of statistical physics.

  10. Metsanduse kommunikatsioonile tuleb kasuks inimeste metsa toomine / Mari-Liis Kitter, Toomas Kelt, Regina Hansen ; intervjueerinud Kertu Kärk

    Index Scriptorium Estoniae

    Kitter, Mari-Liis

    2014-01-01

    Metsanduse kommunikatsiooni suurimatest väljakutsetest ja saavutustest räägivad vestlusringis RMK kommunikatsioonijuht Mari-Liis Kitter, Eesti Metsaseltsi kommunikatsioonijuht Toomas Kelt ja Erametsakeskuse, Eesti Metsa- ja Puidutööstuse Liidu ja Eesti Erametsaliidu kommunikatsioonijuht Regina Hansen

  11. Family Health Strategy professionals' view on the effects of Hansen's disease training

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Alves de Souza

    2015-08-01

    Full Text Available OBJECTIVEEvaluating how professionals of family health teams from three municipalities of Pernambuco perceive and interpret the effects of Hansen's disease training.METHODSA qualitative study using the perspective of Habermas. Six focus groups, totaling 33 nurses and 22 doctors were formed. The guide consisted of: reactions to training, learning, transfer of knowledge and organizational results.RESULTSThere were recurrent positive opinions on instructor performance, course materials, and an alert attitude to the occurrence of cases; the negative points were about lack of practical teaching, a lot of information in a short period of time and little emphasis on basic content. Low perceived self-efficacy and low locus of control, ambiguity, conflict of skills and the lack of support for the learning application. Nurses showed greater dissatisfaction with the organizational support.CONCLUSIONThe low effectiveness of training reveals the need to negotiate structured training from work problematization, considering performance conditions.

  12. Necrose de canto medial associado a hanseníase virchowiana: relato de caso

    Directory of Open Access Journals (Sweden)

    Leiser Franco

    2010-12-01

    Full Text Available O caso em relato aborda uma etiologia rara para necrose de canto medial da pálpebra com comprometimento do sistema canalicular em uma paciente em tratamento para hanseníase virchowiana. O exame histopatológico da lesão necrótica evidenciou reação inflamatória granulomatosa com acúmulo de histiócitos e presença de bacilos álcool-ácido resistentes. Após tratamento medicamentoso a paciente apresentou uma evolução favorável com recuperação espontânea da arquitetura do canto medial, porém com destruição total do sistema canalicular.

  13. [Family Health Strategy professionals' view on the effects of Hansen's disease training].

    Science.gov (United States)

    Souza, Ana Lúcia Alves de; Feliciano, Katia Virginia de Oliveira; Mendes, Marina Ferreira de Medeiros

    2015-08-01

    Evaluating how professionals of family health teams from three municipalities of Pernambuco perceive and interpret the effects of Hansen's disease training. A qualitative study using the perspective of Habermas. Six focus groups, totaling 33 nurses and 22 doctors were formed. The guide consisted of: reactions to training, learning, transfer of knowledge and organizational results. There were recurrent positive opinions on instructor performance, course materials, and an alert attitude to the occurrence of cases; the negative points were about lack of practical teaching, a lot of information in a short period of time and little emphasis on basic content. Low perceived self-efficacy and low locus of control, ambiguity, conflict of skills and the lack of support for the learning application. Nurses showed greater dissatisfaction with the organizational support. The low effectiveness of training reveals the need to negotiate structured training from work problematization, considering performance conditions.

  14. Atypical Hansen's disease presenting as florid verrucous plaques on the lower extremities: a case report.

    Science.gov (United States)

    Yuchua-Guillen, Angela; Dofitas, Belen L

    2012-06-01

    Verrucous leprosy is rare, with only 18 cases reported in the literature. Visceral involvement is frequent but often overlooked, causing significant morbidity and mortality. A 45-year-old Filipino male with a 16-year history of hyperpigmented, hypoesthetic plaques, amputated digits, enlarged ulnar nerve, and cardiovascular congestion was diagnosed with Hansen's disease-lepromatous type. He had multiple cauliflower-like nodules and plaques with foul-smelling discharge on the lower extremities presenting a diagnostic dilemma. After an exhaustive search, the causative agent for these verrucous nodules was confirmed to still be Mycobacterium leprae. In addition, he had glomerulonephritis, hypertension, congestive heart failure, deep venous thrombosis, neuritis, keratitis, and glaucoma, which are all complications of advanced leprosy and multiple attacks of erythema nodosum leprosum reactions. He was treated with a multibacillary regimen of Rifampicin, Dapsone, Clofazimine, and systemic corticosteroids, with remarkable improvement. © 2012 The International Society of Dermatology.

  15. Nerve abscess in Hansen's disease as part of immune reconstitution inflammatory syndrome: a case report.

    Science.gov (United States)

    Ali, Neema M; Nayak, Kashinath; Kumar, Pramod

    2017-02-01

    Immune reconstitution inflammatory syndrome is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy resulting from restored immunity to specific infectious or non-infectious antigens. A 36-year-old male patient on highly active antiretroviral therapy of six months duration, presented with reddish, tender lesions over medial aspect of arm and a single, anaesthetic patch. Tender fluctuant swellings were seen on the medial aspect of left forearm. A few of them had ruptured spontaneously discharging pus. A skin biopsy from the anaesthetic patch showed caseating epitheloid granulomas. A diagnosis of Hansen's disease borderline tuberculoid in type 1 reversal reaction, with formation of nerve abscess due to Immune Reconstitution Inflammatory Syndrome was made. The patient was started on multibacillary multidrug therapy as per WHO guidelines and highly active antiretroviral therapy was continued.

  16. The Exile of Hansen's Disease Patients to Moloka'i: A Diffusion of Innovations Perspective.

    Science.gov (United States)

    Pitman Harris, Adrea; Matusitz, Jonathan

    2016-07-01

    This article analyzes the exile of patients with Hansen's disease (leprosy) to Moloka'i (Hawaii) by applying the diffusion of innovations (DoI) theory. Developed by Rogers, DoI posits that an innovation (i.e., idea, movement, or trend) is initiated within a culture. Then, it is diffused via particular channels across diverse cultures. Instead of evolving independently, innovations diffuse from one culture to another through various forms of contact and communication. In the context of this analysis, the objective is to examine how the diffusion of certain ideas, namely, abolishing the stigma associated with leprosy, could have improved the lives of Hawaiians. An important premise of this article is that the Hawaiian government barely applied the tenets of DoI, which is the reason why many people lost their lives. So, this article seeks to explore what could have been done to improve their situation and what pitfalls should be avoided in the future.

  17. Squamous cell carcinoma masquerading as a trophic ulcer in a patient with Hansen's disease.

    Science.gov (United States)

    Venkatswami, Sandhya; Anandan, S; Krishna, Nikilesh; Narayanan, C D

    2010-12-01

    Nonhealing trophic ulcers in leprosy are a common phenomenon, but acute malignant transformations of the same are relatively rare. This study reports on a 35-year-old man previously treated for Hansen's disease with a squamous cell carcinoma involving the right foot with rapid lymphatic spread. He was being treated as a benign trophic ulcer for more than 12 months until he started developing huge inguinal lymph nodes and the ulcer rapidly increased in size. Squamous cell carcinomas are known to occur in ulcers of considerable duration but such rapid growth in such a short duration and rapid lymphatic spread is unusual in Marjolin's ulcer as the lymphatics are usually destroyed because of previous inflammation and scarring.

  18. Hansen Disease among Micronesian and Marshallese Persons Living in the United States

    Science.gov (United States)

    Woodall, Patricia; Rajan, Latha

    2011-01-01

    An increasing proportion of Hansen disease cases in the United States occurs among migrants from the Micronesian region, where leprosy prevalence is high. We abstracted surveillance and clinical records of the National Hansen’s Disease Program to determine geographic, demographic, and clinical patterns. Since 2004, 13% of US cases have occurred in this migrant population. Although Hawaii reported the most cases, reports have increased in the central and southern states. Multibacillary disease in men predominates on the US mainland. Of 49 patients for whom clinical data were available, 37 (75%) had leprosy reaction, neuropathy, or other complications; 17 (37%) of 46 completed treatment. Comparison of data from the US mainland with Hawaii and country-of-origin suggests under-detection of cases in pediatric and female patients and with paucibacillary disease in the United States. Increased case finding and management, and avoidance of leprosy-labeled stigma, is needed for this population. PMID:21762573

  19. 蒙拉德(IB Monrad Hansen)的小岛

    Institute of Scientific and Technical Information of China (English)

    王彤

    2010-01-01

    与地球上大多数国家相比较,丹麦都是一个小国,我们的主人公伊勃蒙拉德(IB Monrad Hansen)就住在丹麦的406个岛屿中的一个小岛上。有艺术家曾对我说蒙拉德不喜欢与人类交往,但以我与他交往的经验来说,我从没有感到由于我的出现而使他受到非人道的心理压力。频繁活动于美术馆画廊的艺术家大多受过丹麦皇家美术学院的洗礼,蒙拉德自然也不例外。在皇家美术学院读书

  20. Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs.

    Science.gov (United States)

    Paseta, Lorena; Potier, Grégory; Abbott, Steven; Coronas, Joaquín

    2015-02-14

    Hansen solubility parameters (HSP) have found their greatest use in the evaluation of solvent-polymer chemical interactions. Given their great interest among the scientific community, host-guest interactions in metal-organic frameworks (MOFs), with organic and inorganic moieties, could benefit from a HSP approach. In this work we have initiated the application of HSP to the study of caffeine encapsulation in MOFs ZIF-8 and NH2-MIL-88B(Fe). However, the availability of HSP for MOFs is nearly zero. As a first step to evaluating the potential of HSP for rational design we have made the simplifying assumption that the HSP distance of the caffeine-ligand interaction (i.e. ignoring the metal and the MOF structure) dominates the ability to form a MOF host-guest system. Although much work remains to be done, the first indications are that this approach has much potential.

  1. New procedure for the determination of Hansen solubility parameters by means of inverse gas chromatography.

    Science.gov (United States)

    Adamska, K; Bellinghausen, R; Voelkel, A

    2008-06-27

    The Hansen solubility parameter (HSP) seems to be a useful tool for the thermodynamic characterization of different materials. Unfortunately, estimation of the HSP values can cause some problems. In this work different procedures by using inverse gas chromatography have been presented for calculation of pharmaceutical excipients' solubility parameter. The new procedure proposed, based on the Lindvig et al. methodology, where experimental data of Flory-Huggins interaction parameter are used, can be a reasonable alternative for the estimation of HSP values. The advantage of this method is that the values of Flory-Huggins interaction parameter chi for all test solutes are used for further calculation, thus diverse interactions between test solute and material are taken into consideration.

  2. Hansen's disease: the need for increased healthcare provider awareness and re-training.

    Science.gov (United States)

    Ojinmah, U R; Onyekonwu, C L; Ozoh, G A; Onyekonwu, G C

    2012-01-01

    Leprosy continues to be a challenge worldwide. In 2009, the World Health Organisation (WHO) reported 244,796 new cases worldwide. Of this, South East Asia, South Americas and Africa have the highest number of new cases. To highlight misdiagnosis of Hansen's disease as a drawback to eradication of leprosy. A retrospective study of cases of Hansen's disease misdiagnosed by clinicians who were seen in the skin clinics of two tertiary institutions in South-East Nigeria over a one year period. Of the nine misdiagnosed cases, three were females while six were males. Apart from one child of six years old, the rest of the patients were adults. Referring diagnoses included chronic osteomyelitis, acromegaly, dermatitis and depression. One of the patients presented with a reversal reaction (erythema nodosum leprosum) following treatment in a peripheral health facility. Confirmation of the diagnosis was based on slit skin smears for Acid Fast Bacilli carried out in the side laboratory of skin clinic UNTH, Ituku-Ozalla, Enugu state (four patients) and mile four hospital, Abakaliki, Ebonyi State( three patients). All the smears were positive. Patients were commenced on multi drug therapy and all showed marked clinical improvement following drug therapy. Eradication of leprosy may not be feasible if health care providers are ignorant of the different presentations of the disease. A high index of suspicion for leprosy is needed among health care workers in endemic areas. Development of tools for early diagnosis and detection of infection, improvement in existing tools for data collection, provision of guidelines and training materials on vital information for leprosy control will all contribute to the continued success of the National Tuberculosis and Leprosy Control Programme in Nigeria.

  3. Edema na hanseníase: aspectos clínicos e terapêuticos

    Directory of Open Access Journals (Sweden)

    Valentini Attilio

    1999-01-01

    Full Text Available Durante o curso da hanseníase, o edema comumente descrito como um sintoma de estados reacionais, pode ocorrer. Tanto o diagnóstico como a terapêutica adequada são, freqüentemente, difíceis de conseguir e assim podem acarretar permanente dano aos membros inferiores. Em um ano de acompanhamento, pacientes hansenianos - 10 multibacilares e 1 paucibacilar -, que foram submetidos a um protocolo clínico para o diagnóstico e classificação histopatológica, apresentaram clinicamente edema, localizado ou sistêmico. Entre estes pacientes, cinco apresentaram simultaneamente outros sintomas de reação, 4 foram classificados como reação Tipo I e um como reação tipo II. Por outro lado, três pacientes não apresentaram reação no momento do diagnóstico, mas desenvolveram alguns aspectos de reação posteriormente (2 tiveram neurite e um teve reação tipo I. Os edemas observados precedendo ou associados a quadros reacionais apresentaram ótima resposta clínica às drogas de ação anti-inflamatória (corticóide, talidomida e pentoxifilina utilizadas para o tratamento dos estados reacionais, na ausência de qualquer outro tratamento normalmente usado para edema. Embora necessitem ser confirmados por estudos controlados, estes dados sugerem fortemente que mecanismos imunológicos estejam envolvidos na fisiopatologia dos edemas na hanseníase.

  4. Controle da hanseníase no Estado de São Paulo: análise histórica Control de la hanseníasis en el Estado de Sao Paulo, Brasil: análisis histórico Hansen's disease control in the State of São Paulo: a historical analysis

    Directory of Open Access Journals (Sweden)

    Paula Araujo Opromolla

    2011-02-01

    Full Text Available Para controle da hanseníase, doença infectocontagiosa conhecida desde os tempos bíblicos, são mostradas as intrincadas convergências de histórias nacionais, de políticas médicas, governamentais e internacionais. O estudo descreve a história e as ações de controle da hanseníase, a partir do começo do século XIX, no estado de São Paulo, e sua conexão com o desenvolvimento da saúde pública, utilizando análises bibliográficas e documentais.Para control de la hanseníasis, enfermedad infectocontagiosa conocida desde los tiempos bíblicos, se muestran las intrincadas convergencias de historias brasileñas, de políticas médicas, gubernamentales e internacionales. El estudio describe la historia y las acciones de control de la hanseníasis, a partir del comienzo del siglo XIX, en el estado de Sao Paulo, y su conexión con el desarrollo de la salud pública, utilizando análisis bibliográficas y documentales.Leprosy is an infectious contagious disease known since Biblical times. Global effort for disease control reveals intricate convergences of national history and of medical, governmental, and international policies. The study describes the history of Hansen's disease and control actions undertaken in the state of São Paulo starting in the 19th century and its connection with the development of public health in that state, by means of a bibliographic and documental analysis.

  5. The generalization of the Mermin-Wagner theorem and the possibility of long-range order in the isotropic discrete one-dimensional quantum Heisenberg model

    Energy Technology Data Exchange (ETDEWEB)

    Rudoy, Yu.G., E-mail: rudikar@mail.ru [Department of Theoretical Physics, People' s Friendship University of Russia, ul. Miklukho-Maclaya 6, 117981 Moscow (Russian Federation); Kotelnikova, O.A. [Department of Magnetism, Physical Faculty, Lomonosov Moscow State University, Vorobievy Gory, 119991 Moscow (Russian Federation)

    2012-10-15

    The problem of existence of long-range order in the isotropic quantum Heisenberg model on the D=1 lattice is reconsidered in view of the possibility of sufficiently slow decaying exchange interaction with infinite effective radius. It is shown that the macrosopic arguments given by Landau and Lifshitz and then supported microscopically by Mermin and Wagner fail for this case so that the non-zero spontaneous magnetization may yet exist. This result was anticipated by Thouless on the grounds of phenomenological analysis, and we give its microscopic foundation, which amounts to the generalization of Mermin-Wagner theorem for the case of the infinite second moment of the exchange interaction. Two well known in lattice statistics models - i.e., Kac-I and Kac-II - illustrate our results.

  6. Methanetrisulfonic Acid: A Highly Efficient Strongly Acidic Catalyst for Wagner-Meerwein Rearrangement, Friedel-Crafts Alkylation and Acylation Reactions. Examples from Vitamin E Synthesis

    Directory of Open Access Journals (Sweden)

    Francesco Pace

    2009-04-01

    Full Text Available Methanetrisulfonic acid had been prepared for the first time over 140 years ago, but it was used only scarcely in chemical transformations. In the course of our activities dealing with key-steps of industrial syntheses of vitamins, e.g. economically important vitamin E (acetate, we found that methanetrisulfonic acid is an extremely effective catalyst in a variety of reactions. Examples of its applications are Wagner-Meerwein rearrangements, Friedel-Crafts alkylations and ring closures, as well as acylation reactions. Use of this catalyst in truly catalytic amounts (0.04-1.0 mol% resulted in highly selective transformations and yields over 95%. (Remark by the authors: We are describing only one example each for the various types of reactions. Therefore, it would be more appropriate to write (here and in the Introduction and in the Conclusion sections: “Wagner-Meerwein rearrangement, Friedel-Crafts alkylation and ring closure, as well as acylation reactions”

  7. The pre-Anschluss Vienna School of Medicine - the physicians: Sigmund Freud (1856-1939), Julius Wagner-Jauregg (1857-1940) and Karel Wenckebach (1864-1940).

    Science.gov (United States)

    Shaw, Lily Bzl; Shaw, Robert A

    2016-05-01

    Three physicians are discussed. Sigmund Freud, probably the best-known member of the Vienna School of Medicine, was the path-breaking pioneer in psychoanalysis and psychotherapy. Julius Wagner-Jauregg was a psychiatrist who discovered the link between iodine deficiency and goitre and also developed malaria therapy to treat progressive paralysis caused by syphilis for which he was awarded the Nobel Prize. Karel Wenckebach, the pioneering Dutch cardiologist, is best known for the Wenckebach block. After the Anschluss, fate dealt very different hands to these three physicians. Freud fled to London where he soon died. Wagner-Jauregg, who had some pan-Germanic sympathies as well as views on eugenics, left a controversial legacy. The Dutch cardiologist Wenckebach died in Vienna shortly after his homeland had been invaded in 1940 by that of his hosts. © IMechE 2014.

  8. Modelo natural de dicotomía TH1-TH2: La enfermedad de Hansen Th1-TH2 balance. Natural model: Hansen'disease

    Directory of Open Access Journals (Sweden)

    N. L Vaquero

    2010-09-01

    Full Text Available La enfermedad de Hansen producida por el Mycobacterium leprae, es una enfermedad infecciosa cuyo amplio espectro clínico e inmunopatológico se correlaciona con los diferentes patrones de respuesta Th1/Th2. La activación preferencial de esas subpoblaciones de linfocitos T CD4 juega un rol importante en su patogenia y constituye un modelo natural de esa dicotomía de la respuesta inmune. Ambas formas polares de la lepra presentan un perfil definido de secreción de citoquinas: Th1 (IL2 e IFN? en el polo tuberculoide y Th2 (IL4, IL5, IL10 en el polo lepromatoso. En el primer caso, la respuesta celular adecuada estimula la activación macrofágica y lleva a la destrucción del bacilo. Las lesiones son escasas y limitadas a la piel y nervios periféricos. En el segundo en cambio, la respuesta celular es casi nula y los bacilos se multiplican descontroladamente dentro de los macrófagos, llevando a la diseminación de las lesiones y afectación de otros órganos. La inmunidad humoral está exacerbada y hay un alto nivel de anticuerpos que no pueden eliminar el germen intracelular. Los factores que determinan la diferenciación hacia una respuesta Th1 ó Th2 no se han esclarecido totalmente. Se han postulado varias hipótesis que hacen referencia a factores genéticos, prevalencia de citoquinas en el microambiente celular, disfunción macrofágica; alteración en los receptores Toll de la inmunidad innata, en la expresión de moléculas coestimulatorias, etc En los últimos años se han descubierto nuevas subpoblaciones de linfocitos, (CD4+ CD25+, Tr1, Th3 y Th17 que estarían implicadas en la desregulación de estas respuestas inmunes.Hansen' disease, caused by Mycobacterium leprae, is an infectious illness whose wide clinical and immunopathologic spectrum correl with different Th1/Th2 responses patterns. The prefferencial activation of the CD4 T cells subset play an important rol in it's pathogenia and provides a natural model of that balance

  9. Het testament van Richard Wagner: Nederlandse tijdschriften in het fin de siècle en de toekomst van de muziek

    Directory of Open Access Journals (Sweden)

    Josine Meurs

    1997-12-01

    Full Text Available Richard Wagner (1813-1883 was tijdens zijn leven al de meest spraakmakende componist. Dit had alles te maken met zijn ambitie de gehele kunst hoogstpersoonlijk een nieuwe, revolutionaire richting te geven. Het verzekerde hem van de gespannen aandacht van verschillende Nederlandse tijdschriften, maar had eveneens tot gevolg dat zijn grootste aanhangers, in Nederland verzameld rond het Maandblad voor Muziek, na zijn dood het spoor bijster raakten.

  10. Maxwell-Wagner relaxation and magnetodielectric properties of Bi0.5La0.5MnO3 ceramics

    Science.gov (United States)

    Turik, A. V.; Pavlenko, A. V.; Reznichenko, L. A.

    2016-08-01

    The complex permittivity ɛ = ɛ'- iɛ″ of manganite bismuth-lanthanum Bi0.5La0.5MnO3 ceramics has been measured at temperature T = 78 K in the frequency range f = 200-105 Hz and in the magnetic induction range B = 0-5 T. Dielectric relaxation and the pronounced magnetodielectric effect have been detected. The explanation based on the superposition of Maxwell-Wagner relaxation and the magnetoresistance effect has been proposed.

  11. Scientific Fellow of Max Planck Institute of Plasma Physics (IPP) and European Physical Society President Elect F. Wagner at ATLAS experiment with Collaboration Spokesperson P. Jenni on 22 September 2006.

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    Scientific Fellow of Max Planck Institute of Plasma Physics (IPP) and European Physical Society President Elect F. Wagner at ATLAS experiment with Collaboration Spokesperson P. Jenni on 22 September 2006.

  12. Violência e profilaxia: os preventórios paulistas para filhos de portadores de hanseníase

    Directory of Open Access Journals (Sweden)

    Yara Nogueira Monteiro

    1998-07-01

    Full Text Available Esse artigo analisa como que a prática do isolamento compulsório dos pacientes de hanseníase no Estado de São Paulo contribuiu para que o estigma da hanseníase atingisse pessoas que nunca portaram a doença, como foi o caso das crianças sadias filhas de portadores de hanseníase. Discute como que os ideais eugênicos contribuíram para a formação de uma postura médica que, mesmo a revelia dos progressos científicos e das recomendações internacionais, perpetuaram medidas de discriminação e segregação dessas crianças. Demonstra como estas acabaram por se tornar portadoras de um "estigma congênito" que as acompanharia por toda a vida e como isto resultou na diminuição de possibilidades de vida, obrigando-as a esconder sua situação de internas ou egressas de Preventório se quisessem competir em igualdade de condições quando da procura de emprego ou no estabelecimento de relações sociais. Analisa ainda a vida dentro dos Preventórios, a separação da família e o quotidiano de centenas de vidas moldadas dentro de estruturas de controle, nas quais a violência e o arbítrio se faziam em nome de uma visão distorcida de profilaxia.This work analyses how the compulsory isolation practice of Hansen's disease patients in the State of São Paulo has contributed for the Hansen's stigma affecting people that never had the disease - the case of healthy children of Hansen's disease carriers. The present article discusses how eugenic ideals have contributed for the formation of a medical posture that even despite scientific advances and international recommendations has perpetuated discriminatory and segregational measures against these children. The paper shows how such children ended up by carrying life long "inborn stigma" that has resulted in the hindering of their life possibilities that made them hide their former condition of interns or egresses of preventive centers to compete in society under equal conditions for jobs and

  13. Physical and meteorological data from HELLAND-HANSEN from the Kara Sea from 08 June 1966 to 21 June 1966 (NODC Accession 9600035)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical and meteorological data from HELLAND-HANSEN from the Kara Sea. Data were collected by the University of Bergen Geophysical Institute from 08 June 1966 to 21...

  14. Lewis and Clark National Wildlife Refuge and Julia Butler Hansen Refuge for the Columbian White-tailed Deer: Comprehensive Conservation Plan and Environmental Impact Statement

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Lewis and Clark NWR and Julia Butler Hansen Refuge for the Columbian White-tailed Deer...

  15. Praktek Preventive untuk Menanggulangi Karies

    Directory of Open Access Journals (Sweden)

    Edi Hartini Sundoro

    2015-10-01

    Full Text Available Treatment that emphasize preventive aspects and less invasive has been recommended by the WHO since 1992. Therefore with the advancement of science and technology of caries treatment this recommendation should be developed. Clinical and radiological examination to determine the diagnosis of caries lesion, evaluation of risk f actors, treatment of caries lesion and maintenance programme will be reviewed.

  16. Lest we forget Hansen's disease (leprosy): an unusual presentation with an acute onset of inflammatory polyarthritis and the rheumatology experience.

    Science.gov (United States)

    Sheetal, Salvi; Arvind, Chopra

    2009-04-01

    Several forms of arthritis and rheumatism can sometimes complicate leprosy. However, its presentation as an acute onset arthritis is unusual. We report two adult male naïve patients who presented to our rheumatology outpatient clinic with acute onset inflammatory polyarthritis, skin rash and mild sensory neurodeficit. Borderline lepromatous leprosy (in type I lepra reaction) was diagnosed. We also refer to 19 case records of Hansen arthritis in the clinic database (1998-2007) from approximately 35,000 patients and a community study to highlight the missed diagnosis of Hansen's disease and its unusual association with rheumatoid arthritis. In countries like India where leprosy is endemic, this disease also merits attention in rheumatology clinics.

  17. Prevenção de incapacidades em hanseníase: realidade numa unidade sanitária

    Directory of Open Access Journals (Sweden)

    Sâmia Amire Maluf

    1985-12-01

    Full Text Available Na hanseníase, 1/3 dos casos avançados ou não tratados apresenta algum tipo de incapacidade física, além dos preconceitos e crenças que são gerados pelas deformidades que o paciente pode vir a apresentar, se não tratado adequadamente. Tendo por base esta problemática da doença, um grupo de profissionais formado por enfermeiros, fisioterapeuta, terapeuta ocupacional, médicos e assistente social, realizou um estudo das incapacidades dos pacientes de hanseníase, detectadas através do exame físico. Este estudo objetivou identificar o comprometimento sensitivo e motor dos membros superiores e inferiores e da face. Apresenta também o desenvolvimento da pesquisa como necessidade para sistematizar a assistência a ser prestada numa unidade sanitária.

  18. AVALIAÇÃO DOS PARÂMETROS DE SOLUBILIDADE DE HANSEN DO PARACETAMOL E DE ÓLEOS ESSENCIAIS

    OpenAIRE

    GLICIANE RAMOS AZEVEDO

    2013-01-01

    Os parâmetros de solubilidade de Hansen baseiam-se na teoria de que a energia coesiva total pode ser dividida em três componentes individuais: forças de dispersão, energias polares e ligações de hidrogênio. São parâmetros utilizados, geralmente, para avaliar a compatibilidade e solubilidade entre materiais. Para determinação desses parâmetros, utilizou-se a metodologia de Hansen, uma técnica fácil, de baixo custo e que não requer conhecer as características físico-químicas das substâncias. Te...

  19. Identificando barreiras para aderência ao tratamento de hanseníase Obstacles to compliance with treatment for Hansen's disease

    Directory of Open Access Journals (Sweden)

    Zoica Bakirtzief

    1996-12-01

    Full Text Available Esta investigação visa a identificar alguns fatores associados à não-aderência ao tratamento poliquimioterápico da hanseníase. O trabalho utiliza o referencial teórico das representações sociais como base de sustentação metodológica da investigação. Foram entrevistados dois grupos de pacientes ambulatoriais em tratamento poliquimioterápico: "aderentes" e "não-aderentes" ao tratamento, provenientes de dois serviços de saúde distintos. Nas entrevistas, foi observada a presença de uma representação comum entre os discursos empregada como metáfora para explicar o tratamento: a figura de uma batalha em que o bacilo é retratado como uma ameaça, o doente como vítima, o medicamento como a principal arma de combate e os profissionais da saúde como os heróis ou santos. Foi observado também que o medicamento é representado por ambos os sujeitos como sendo algo ora benéfico ora maléfico ao bem-estar do paciente. Além disso, a relação médico-paciente parece representar um ponto importante, pois nota-se que a confiança depositada na capacidade do médico para solucionar o problema divide sujeitos "aderentes" dos "não-aderentes" entrevistados.This research project aimed at identifying some of the factors related to leprosy patient compliance with the multidrug treatment regimen. The methodological framework of the Social Representations Theory was used. Two groups of patients were interviewed: compliant and non-compliant with treatment and those coming from two different health services. We observed a common understanding about treatment in the various interviews, expressed as a metaphor to describe the treatment experience: the figure of a battle in which the bacillus is portrayed as a threat, the patient as a victim, the medication as a weapon and the health professional as a hero or saint. Still, the medication is represented as being both good and bad for the patient's well-being. Finally, quality of the physician

  20. Saladused ja narri kuju Anton Hansen Tammsaare poeetikas. Secrets and the Figure of the Fool in Anton Hansen Tammsaare’s Poetics

    Directory of Open Access Journals (Sweden)

    Maarja Vaino

    2012-04-01

    Full Text Available This article examines the poetics of Anton Hansen Tammsaare’s texts with a focus on the manifestation and function of the irrational. Tammsaare has been regarded first and foremost as the author of earthy, realistic novels about the peasantry; as a writer he has been deemed a rationalist and a skeptic. However, the criticism of the 1930s also recognizes a dimension of irrationality in his works. A variety of features are listed through which Tammsaare communicates the non-realistic aspects of his characters` perception of the world: the creation of a mysterious quality in the text; paradoxical situations and trains of thought; impulsive and intuitive behaviour on the part of the characters. This line of research was interrupted after World War II: in Soviet literary scholarship, topics that diverged from realism, or „closeness to life” were frowned upon. Therefore the dimension of irrationality in Tammsaare’s works has yet to receive in-depth consideration. This article seeks to develop the insights of earlier, pre-war Tammsaare critics and carry them further. Closer examination is devoted to the secret as an impetus for events in Tammsaare’s texts, as well as to that dimension of the irrational in Tammsaare which is expressed through the archetype of the fool. Though secrets in the abstract sense could be seen as an aspect influencing interpersonal relations between characters, Tammsaare uses the figure of the fool to bring characters into his works whose strange and incomprehensible behaviour keeps events „going”, creating more and more complicated or insoluble situations, and throwing the well-ordered world into chaos. Tammsaare characteristically constructs his fictional world in such a way that externally plausible circumstances underscore the behaviour patterns of characters in a state of psychological tension, thereby bringing their internal and unconscious worlds into view. What emerges out of this process is a particular

  1. Hanseníase tuberculóide em paciente com Aids Tuberculoid leprosy in aids patient

    Directory of Open Access Journals (Sweden)

    Régio José Santiago Girão

    2005-12-01

    Full Text Available Relata-se o caso de uma criança de oito anos, portadora de Aids, que desenvolveu hanseníase tuberculóide antes do início da terapia anti-retroviral. Apresentava lesões ulceradas nos membros, Mitsuda de 8,5mm, hipoestesia em perna esquerda, e o diagnóstico de hanseníase foi definido pela imuno-histoquímica antiproteína S-100, que mostrou fragmentos de ramos nervosos no interior dos granulomas. A incidência da hanseníase não aumentou com o advento da Aids, e não há modificações na apresentação clínica ou na resposta terapêutica nos casos de hanseníase associados à Aids. Também não se observou neste caso o desenvolvimento da reação tipo 1 como resultado da reconstituição imunológica devido ao tratamento anti-retroviral.The authors present a 8 year-old child with AIDS who developed tuberculoid leprosy prior the beginning of the anti-retroviral treatment. The pacient presented ulcered lesions in arms and legs, the Mitsuda reaction was 8,5 mm, there was hypostesia of the left leg and the leprosy diagnosis was reached mainly supported by the anti-S100 protein immunohistochemistry staining that showed fragments of nerve branches inside granulomas. The incidence of leprosy has not increased because of AIDS. There haven’t been changes in the clinical presentation and in the response to therapy in cases of leprosy associated with AIDS. We haven’t also observed development of type 1 reaction in this patient resulting from restoring of the immune response after the anti-retroviral treatment.

  2. Fatores associados à recidiva em hanseníase em Mato Grosso

    Directory of Open Access Journals (Sweden)

    Silvana Margarida Benevides Ferreira

    2011-08-01

    Full Text Available OBJETIVO: Analisar fatores associados à ocorrência de recidiva em hanseníase. MÉTODOS: Estudo retrospectivo caso-controle com 159 pacientes maiores de 15 anos diagnosticados com hanseníase em cinco municípios do estado de Mato Grosso, cujas unidades de saúde eram consideradas de referência para o atendimento. O grupo de casos incluiu 53 indivíduos com recidiva de 2005 a 2007 e foi comparado ao grupo controle (106 com alta por cura em 2005, pareados por sexo e classificação operacional. Foram usados dados do Sistema de Informação de Agravos de Notificação, prontuários e entrevistas. Utilizou-se regressão logística condicional e abordagem hierárquica. RESULTADOS: Após análise ajustada, mostraram-se associados à ocorrência de recidiva: indivíduos residentes em casas alugadas (OR = 4,1; IC95%:1,43;12,04, em domicílio de madeira/taipa (OR = 3,2; IC95%: 1,16;8,76, que moravam com mais de cinco pessoas (OR = 2,1; IC95% : 1,03;4,36, com transtorno de uso de álcool (OR = 2,8; IC95%: 1,17;6,79, irregularidade do tratamento (OR = 3,8;IC95%: 1,44;10,02, sem esclarecimento sobre a doença/tratamento (OR = 2,6; IC95%: 1,09;6,13, que usavam transporte coletivo para o acesso à unidade de saúde (OR = 5,5; IC95%: 2,36;12,63, forma clínica da doença (OR = 7,1; IC95%: 2,48;20,52 e esquema terapêutico (OR = 3,7; IC95%: 1,49;9,11. CONCLUSÕES: Os fatores preditivos de recidiva relacionam-se com condições de moradia, hábitos de vida, organização dos serviços de saúde, formas clínicas e esquemas terapêuticos. Cabe aos serviços de saúde oferecer orientações adequadas aos pacientes, bem como garantir a regularidade do tratamento.

  3. Flying a Wagner Kite

    DEFF Research Database (Denmark)

    Parly, Nila Charlotte

    2010-01-01

    A meditation on the process of rehearsing the final scene of Das Rheingold at The Danish Royal Theatre......A meditation on the process of rehearsing the final scene of Das Rheingold at The Danish Royal Theatre...

  4. ANTI M. leprae IgM ANTIBODY DETERMINATION BY ULTRAMICROIMMUNOENZYMATIC (UMELISA HANSEN FOR THE DIAGNOSIS AND MONITORING LEPROSY

    Directory of Open Access Journals (Sweden)

    Adriana TORRELLA

    1998-05-01

    Full Text Available The relationship between the IgM antibody response, antigenic load as well as the clinical improvement after chemotherapy was studied in order to obtain useful data for the early diagnosis and monitoring leprosy. A level of 82% (94/115 agreement was obtained between IgM UMELISA HANSEN and slitskin smear examination. Discrepant results were observed in 16 patients who showed positive IgM response despite negative by the skin smear examination. In these patients, the IgM response was seen to be associated to the early signal for bacilli recurrence in the skin. In one of these patients the presence of bacilli was demonstrated in the skin, two months after IgM antibodies being detected by UMELISA HANSEN. Also in one of the treated patients positive by both diagnostic techniques, a remarkable decrease in the IgM antibody levels was seen, correlating with a significant clinical improvement. Moreover it was found a direct relationship between the IgM antibody response and bacterial antigenic load, regardless the time elapsed in the disease's evolution.El UMELISA HANSEN en el diagnostico y seguimiento de la lepra. Se analizó la relación entre la carga antigénica y la respuesta de anticuerpos IgM, el comportamiento de dicha respuesta y la utilidad de su detección para el diagnóstico y seguimiento de la lepra. Se obtuvo un 82% de coincidencia entre los resultados del UMELISA HANSEN y los de la baciloscopía. Este valor se vio afectado fundamentalmente por 16 pacientes con respuesta positiva a IgM y baciloscopía negativa. En estos pacientes de acuerdo a lo reportado, la respuesta IgM puede indicar la reaparición de bacilos, precediendo a su detección en la piel. En uno de estos pacientes se demostró la presencia de bacilos, dos meses después de resultar positivo por el UMELISA HANSEN. Entre los pacientes coincidentes en IgM y baciloscopía positivas con tratamiento quimioterapéutico, se apreció en uno de ellos una notable disminución en los

  5. Hansen Re-Visited: Alternative Methodology for Istanbul Land Use Pattern

    Directory of Open Access Journals (Sweden)

    Kerem Yavuz Arslanlı

    2016-12-01

    Full Text Available In this paper, Hansen model applied to Istanbul districts and increasing the distribution of the population of 3 million were calculated. Istanbul, population and income growth, the service sector, based in the city's development as a result of advances in transportation and telecommunications, the restructuring of the city, and this encourages residential, commercial and office create opportunities for investments. Land-use decision-making process is a very complex includes site selection. Estimates of population growth, starting from the development potential on the one hand, depending on the location of the settlements, and the physical, socio-economic, legal and political characteristics of the functional needs of the city overlaps with each other to create the most effective form is required. In addition, the sub-centers produced a gradual effect of the interaction and the environment as a result of a lot of alternatives for the purpose of evaluating the size of the new centers and, instead, may be decided taking into account the dimension of time. Thus, the development of the whole city and the economic development of the system to provide the most effective when planned. By investing just as it is today, at certain points, and the creation of high-quality urban services bringing the speculation, raising the quality of life of city-wide, but can provide a healthy socio-economic development.

  6. [Children born to Hansen's disease patients in Amami-Oshima, Kagoshima, Japan].

    Science.gov (United States)

    Moriyama, Kazutaka; Kikuch, Ichiro; Ishii, Norihisa

    2009-09-01

    In the Japanese leprosaria, it was very difficult or almost impossible for leprosy patients to give birth to their children. There were various reasons for this situation. Leprosy in the women mostly worsened in pregnancy and some of the children developed leprosy. Because of the chronic nature of the disease, marriage was encouraged in Japanese leprosaria, so that vasectomy was usually enforced in men who were wed, while artificial abortion was enforced in pregnant women. The only one exception was the situation of the Amami Wako-en Leprosarium. The Wako-en Leprosarium was started in 1943, and between 1946 and 1953, it was under American rule. Later it was transferred to Japanese rule. Religions such as Buddhism, Christianity and other religions greatly helped with leprosy patients, and in the Wakoen, it was Catholicism which prevailed. Catholic believer Joan Matsubara (later the secretary of Wako-en), Father Patrick Finn, Kaoru Ohira (director) outlined how children born to Hansen's disease patients would be grown up and made the internal rules of the couples' dormitory, while this was impossible in other leprosaria. Between 1953 and 1954, children were brought up by Matsubara's family or nurses. And since November 1954, children were brought up at nurseries (firstly named "Children's House" and later at "Naze Engel House" and children between 2 and 3 years went to "White Lily House". The children could meet their parents at times and now they are full-fledged grown-up citizens.

  7. Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic.

    Science.gov (United States)

    Leon, Kristoffer E; Salinas, Jorge L; McDonald, Robert W; Sheth, Anandi N; Fairley, Jessica K

    2015-11-01

    In non-endemic countries, leprosy, or Hansen's disease (HD), remains rare and is often underrecognized. Consequently, the literature is currently lacking in clinical descriptions of leprosy complications in the United States. Immune-mediated inflammatory states known as reactions are common complications of HD. Type 1 reactions are typical of borderline cases and occur in 30% of patients and present as swelling and inflammation of existing skin lesions, neuritis, and nerve dysfunction. Type 2 reactions are systemic events that occur at the lepromatous end of the disease spectrum, and typical symptoms include fever, arthralgias, neuritis, and classic painful erythematous skin nodules known as erythema nodosum leprosum. We report three patients with lepromatous leprosy seen at a U.S. HD clinic with complicated type 2 reactions. The differences in presentations and clinical courses highlight the complexity of the disease and the need for increased awareness of unique manifestations of lepromatous leprosy in non-endemic areas. © The American Society of Tropical Medicine and Hygiene.

  8. Recurrence of strongyloides stercoralis infection in a patient with Hansen's disease: a case report.

    Science.gov (United States)

    De Souza, Joelma Nascimento; Machado, Paulo Roberto Lima; Teixeira, Márcia Cristina Aquino; Soares, Neci Matos

    2014-03-01

    In patients with immunosuppressive disorders, S. stercoralis infection may develop into a hyperinfection syndrome which, on rare occasions, may be a life-threatening condition. Therapy of S. stercoralis infection with thiabendazole has been limited, due to its numerous side effects, and has been replaced by albendazole and ivermectin. The present case report describes a case of Strongyloides Hyperinfection Syndrome (SHS) in a patient with Hansen's disease and lack of response to first-line anthelmintic treatment. A 38 year-old man was diagnosed as having borderline lepromatous leprosy. He developed Erythema Nodosum Leprosum and was treated with thalidomide and prednisone. In May 2010 he was diagnosed with S. stercoralis infection and was treated with albendazole. One year later, the stool examination showed continued presence of S. stercoralis larvae. He was treated with ivermectin (6 mg) in a double dose (given 1 month apart) which resulted in larvae excretion clearance. The absence of infection was confirmed three times during a 1 year followup period by stool examination and non-detection of anti-S. stercoralis IgG levels.

  9. Application of Hansen solubility parameters for understanding and prediction of drug distribution in microspheres.

    Science.gov (United States)

    Vay, Kerstin; Scheler, Stefan; Friess, Wolfgang

    2011-09-15

    In an emulsion solvent extraction/evaporation process for the preparation of microspheres the employed solvents have a tremendous influence on the characteristics of the resulting particles. Nevertheless the solvent selection is often based on empirical data rather than on calculated values. The purpose of this investigation was to use the concept of solubility parameters for interpretation and improved understanding of solvent effects in the process of microparticle preparation. Partial solubility parameters of 3-{2-[4-(6-Fluor-1,2-benzisoxazol-3-yl)piperidino]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-on, which was used as a model drug, were determined experimentally using an extended Hansen regression model. Poly(lactide-co-glycolide) microparticles were prepared with an emulsion solvent removal process employing methylene chloride and its mixtures with benzyl alcohol and n-butanol. It could be shown, that the encapsulation efficiency was influenced by the change of the solvent composition during the extraction process. Furthermore the solvent selection had an essential influence on the morphological state of the drug and it could be shown and explained, that by a decrease of the dissolving power a completely amorphous product was obtained.

  10. The expanded Hansen approach to solubility parameters. Paracetamol and citric acid in individual solvents.

    Science.gov (United States)

    Barra, J; Lescure, F; Doelker, E; Bustamante, P

    1997-07-01

    In this study two solubility-parameter models have been compared using as dependent variables the logarithm of the mole fraction solubility, lnX2e, and ln(alpha)/U (originally used in the extended Hansen method), where alpha is the activity coefficient and U is a function of the molar volume of the solute and the volume fraction of the solvent. The results show for the first time the proton-donor and -acceptor hydrogen-bonding capacities of paracetamol, as measured by the acidic and basic partial-solubility parameters. The influence of solvents on the differential scanning calorimetry (DSC) pattern of the solid phases was also studied in relation to the solubility models tested. Citric acid was chosen as a test substance because of its high acidity and its proton donor capacity to form hydrogen bonds with basic solvents. The partial acidic and basic solubility parameters obtained from multiple regression were consistent with this property, validating the model chosen. The results show that the more direct lnX2e variable was more suitable for fitting both models, and the four-parameter model seemed better for describing the interactions between solvent and solute.

  11. Hansen solubility parameters of surfactant-capped silver nanoparticles for ink and printing technologies.

    Science.gov (United States)

    Petersen, Jacob B; Meruga, Jeevan; Randle, James S; Cross, William M; Kellar, Jon J

    2014-12-30

    Optimal ink formulations, inclusive of nanoparticles, are often limited to matching the nanoparticle's capping agent or surface degree of polarity to the solvent of choice. Rather than relying on this single attribute, nanoparticle dispersibility was optimized by identifying the Hansen solubility parameters (HSPs) of decanoic-acid-capped 5 nm silver nanoparticles (AgNPs) by broad spectrum dispersion testing and a more specific binary solvent gradient dispersion method. From the HSPs, solvents were chosen to disperse poly(methyl methacrylate) (PMMA) and nanoparticles, give uniform evaporation profiles, and yield a phase-separated microstructure of nanoparticles on PMMA via film formation by solvent evaporation. The goal of this research was to yield a film that is reflective or transparent depending on the angle of incident light (i.e., optically variable). The nanoparticle HSPs were very close to alkanes with added small polar and hydrogen-bonding components. This led to two ink formulations: one of 90:10 vol % toluene/methyl benzoate and one containing 80:10:10 vol % toluene/p-xylene/mesitylene, both of which yielded the desired final microstructure of a nanoparticle layer on a PMMA film. This approach to nanoparticle ink formulation allows one to obtain an ink that has desirable dispersive qualities, rheology, and evaporation to give a desired printed structure.

  12. Inheritance of resistance to the bean-pod weevil (Apion godmani Wagner) in common beans from Mexico.

    Science.gov (United States)

    Garza, R; Cardona, C; Singh, S P

    1996-03-01

    The bean-pod weevil (BPW), Apion godmani Wagner, often causes heavy losses in crops of common bean (Phaseolus vulgaris L.). Farmers need resistant bean cultivars to minimize losses, cut production costs, stabilize seed yield, and reduce pesticide use and consequent health hazards. To design effective breeding methods, breeders need new and better sources of resistance and increased knowledge of their modes of inheritance. We therefore: (1) compared sources of resistance to BPW, (2) studied the inheritance of resistance, and (3) determined whether the sources possess similar or different genes for BPW resistance. The following sources of resistance, originating from the Mexican highlands, were evaluated for 3 years at INIFAP-Santa Lucía de Prias, Texcoco, Mexico: 'Amarillo 153', 'Amarillo 169', 'Hidalgo 58', 'J 117', 'Pinto Texcoco', 'Pinto 168', and 'Puebla 36'. All except 'Puebla 36' were crossed with the susceptible cultivar 'Jamapa'. 'Amarillo 153' and 'Puebla 36' were crossed with another susceptible cultivar, 'Bayo Mex'. The parents, F1 hybrids, and F2 populations were evaluated for BPW damage in 1992. Backcrosses of the F1 of Jamapa/Pinto 168 to the respective susceptible and resistant parents were also evaluated in 1992. All seven resistant accessions were crossed in all possible combinations, excluding reciprocals. The resulting 21 F1 hybrids and 21 F2 populations were evaluated for BPW damage in 1994. 'J 117' had the highest level of resistance to BPW. 'Pinto Texcoco' and 'Puebla 36' had the highest mean damage score of all seven sources of resistance. The F1 hybrids between susceptible parents and resistant sources were generally intermediate. Two genes segregating independently controlled the BPW resistance in each accession. One gene, Agm, has no effect when present alone, whereas the other gene, Agr, alone conferred intermediate resistance. When both genes were present, resistance to BPW was higher. Based on mean BPW damage scores, all 21 F1 hybrids

  13. Clinico-pathological Correlation in Diagnosis of Hansen's Disease: A Histopathologist's Perspective

    Directory of Open Access Journals (Sweden)

    Reshma Gopal Kini

    2017-06-01

    Full Text Available Objectives: Hansens’s disease follows a chronic course and though curable causes considerable degree of disability and deformity. Key to managing leprosy is it’s early diagnosis and treatment with multidrug regimen. Histopathological evaluation of skin biopsies play crucial role in the correct diagnosis of clinically ambiguous cases. Moreover classifying lesions by the Ridley-Jopling(RJ system gives personalized information about the immulogical status of the individual and also aids in placing the patient in the correct treatment category. Materials and methods: Skin biopsies obtained from newly diagnosed cases of leprosy were included. Paraffin embedded sections stained with hematoxylin- eosin and Fite-Farracco were evaluated for features confirming leprosy and further categorized as per the RJ system. Sensitivity, specificity and concordance rates were looked for. Results: A total of 93 cases were studied after excluding those which had a component of reaction. Among the clinically suspected cases 93% of the biopsies were positive for leprosy. Sensitivity of clinical diagnosis ranged from 60% for borderline(BB to 100% for histioid leprosy. Specificity ranged from 84.5% for borderline tuberculoid (BT to 100% for neuritic leprosy. The agreement between histopathological and clinical diagnosis was more than 90% in all the subclasses except for BT which showed agreement in about 82% of the cases. Two of the cases were recategorized into multibacillary type of leprosy based histopathological evaluation. Conclusion: Confirmation of leprosy by examination of skin biopsy before starting the patient on long term multidrug therapy is invaluable. Experience of the leprologists and adherence to histopathological criteria as per the Ridley Jopling classification yield excellent concordance rates. [J Interdiscipl Histopathol 2017; 5(2.000: 48-54

  14. Perception of social exclusion, neuropathy, and quality of life among Hansen's disease patients.

    Science.gov (United States)

    Borges-de-Oliveira, Roberta; Rocha-Leite, Clarissa I; Araujo-de-Freitas, Lucas; Queiroz, Dermival A; Machado, Paulo R L; Quarantini, Lucas C

    2015-01-01

    Leprosy subjects are strongly affected not only by physical issues such as peripheral neuropathy but also by massive social exclusion that may be related to quality of life (QoL) impairment. However, there are as yet no studies evaluating the impact of perceived stigma in conjunction with neuropathy on QoL and the respective role of each one on QoL. The present study aims to investigate the variations in clinical and socio-demographic profile of Hansen's disease patients with/without perception of social exclusion (PSE) and neuropathy as the impact of both conditions on their QoL. A sample of 160 consecutive leprosy outpatients seeking treatment in two reference centers for leprosy in Brazil was recruited. Patients were assessed using a socio-demographic questionnaire, M.I.N.I. PLUS and SF-36. Data from medical records were also collected. Participants were divided into four groups: control group, perceived stigma, neuropathy, and stigma neuropathy. Of the 160 patients who consented to participate, 78.75% completed the survey. All four groups were similar in terms of demographic parameters, except for occupational status, which was compensated statistically. The group with neuropathy and PSE reported the worst QoL in half of the evaluated domains. The cross-sectional design does not allow cause and effect to be established between variables, and the relatively small sample size may limit the ability to demonstrate a relative decrease in QoL scores from the isolated variables analyzed. The results of this survey show that the presence of both neuropathy and PSE significantly increases impairment in QoL, especially in some specific domains. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  15. [Intraepidermal mass of M. leprae in a case of seborrheic keratosis due to Hansen's disease (LLs)].

    Science.gov (United States)

    Yajima, M; Suzuki, K; Wen, M; Yamada, N; Asano, G

    1995-11-01

    A 67-year-old patient has had exanthema in the lower right limb since 51 years ago (16 years old at onset), which underwent repeated remission and recurrence. At present, he has bilateral symmetrical widespread infiltrating exanthema and asymmetrical marked neuralhypertrophy, and has been diagnosed typical LLs (His father had the same disease). The exanthema recurred several years ago, and the patient is being treated for Hansen's disease. He had a dark brown flat elevation with a rough surface and the size of a small finger tip in his right abdominal skin for approximately 20 years. A biopsy was performed, and the specimen was fixed in 10% formalin and paraffin sections were prepared for histopathologic examination. A part of the specimen was processed forscanning electron microscopic examination. Seborrheic keratosis was diagnosed by H & E staining. Acid-fast (FITE) staining, immunohistochemical staining (keratin, S-100 protein, anti-PGL antibody and anti-BCG antibody) and scanning electron microscopy revealed the presence of bacteria (M. leprae) in the dermal foam cells, the matrix with a banded structure and the squamous epithelial cells which normally lack phagocytosis function. Compared to the basal cells of normal epidermis, the basal cells located adjacent to the dermis affected with seborrheic keratosis showed increased proliferation and more marked characteristics of a germinative cell. The degree of differentiation of the basal cells appeared regressed, and they probably possessed augmented phagocytic activity. The phagocytosed bacteria were probably carried by the epidermal cell cycle toward the surface layer. However, bacteria could not be found in the stratum corneum, probably due to an association with the lysosome.

  16. Aspectos epidemiológicos da mortalidade entre doentes de hanseníase no Estado de São Paulo (1931-1980 Epidemiological aspects of mortality among sufferers from Hansen's disease in S. Paulo State (1931-1980

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    Clovis Lombardi

    1984-04-01

    Full Text Available A partir dos dados do universo de pacientes de hanseníase (n=27.260 falecidos no Estado de São Paulo (Brasil no período entre 1931 e 1980, estuda-se a tendência temporal de alguns caracteres epidemiológicos ligados a atributos pessoais desses pacientes, como: idade, sexo, forma clínica final da doença, bem como do local de ocorrência do óbito, tempo de doença até o óbito. A tendência temporal dos coeficientes de letalidade específica por hanseníase é analisada em confronto com os dados de mortalidade proporcional por hanseníase e de mortalidade geral no Estado de São Paulo, no período. É estudada ainda a tendência temporal do perfil de causas básicas de óbito neste universo, segundo todas as Seções da Classificação Internacional de Doenças, Lesões e Causas de Óbito (Nona revisão - 1975 e, também, segundo algumas de suas Categorias e Subcategorias classicamente conhecidas como relevantes na patologia da hanseníase. No subgrupo de pacientes cuja causa básica de óbito foi a hanseníase (n = 9.907 discute-se a distribuição temporal de alguns caracteres considerados importantes, como: idade, forma clínica final da doença, tempo de doença até a matrícula e tempo de doença até o óbito, cotejando-se os valores observados neste subgrupo com aqueles encontrados para o universo pesquisado. Os resultados obtidos revelam, basicamente: a tendência à melhora do padrão de saúde no universo pesquisado, paralela à observada para o Estado de São Paulo como um todo, porém influenciada por fatores específicos, como a terapêutica sulfônica; b a existência de duas fases nitidamente distintas na tendência das curvas específicas de mortalidade, antes e depois de 1950; c o baixo padrão sócio-econômico e a existência de fenômenos de estigmatização social no grupo estudado.The study comprehends the patients (n=27,260 of Hansen's disease (leprosy deceased in the State of S. Paulo, Brazil, from 1931 to 1980

  17. Considerações acerca dos estados reacionais do portador de hanseníase no município de Itajaí Considerations on reactional states of Itajai's hansen's carriers

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    Jucelene Marchi Blatt

    2001-07-01

    Full Text Available A presente pesquisa teve por objetivo, compreender e avaliar os estados reacionais de pacientes portadores de hanseníase e o tratamento das reações. O método de abordagem do estudo foi indutivo, tendo como base o referencial bibliográfico, tomou-se como fonte de dados os prontuários dos portadores de hanseníase, disponíveis no programa de controle de hanseníase da Secretaria Municipal de Saúde de Itajaí. Através deste trabalho com os 78 pacientes inscritos no programa sujeitos da pesquisa, observou-se que: 60,3% tem de 15-49 anos; 65,4% são do sexo masculino; 70,5% manifestam a forma Virchowiana da doença; 60,3% apresentam estados reacionais durante tratamento; metade destes aproximadamente apresentaram quadro clínico de neurite, tendo sido tratados com prednisona, também se observou outros sintomas clínicos em escala menor como o eritema nodoso hansênico, e o tratamento de escolha sempre que possível é a talidomida; e 11,5% apresentaram para efeitos ao tratamento com multidrogas. A avaliação dos estados reacionais indica que, mais da metade dos portadores em tratamento apresentam esta manifestação imunológica. É julgada pela literatura como conseqüência da doença e possível reação ao esquema poliquimioterápico.The present research had as objetive to undestand and to evaluate the reactional episodes of pacients who had hansen disease and the treatment of the reactions. The method of the approach of the study was made by indicement base the referential bibliografhy, it was taken as data the reports of pacients of hanse's avaible the control program of leprosy in the control of Itajaí. Through this work with the 78 pacients enrolled and subjects of this search it was observed that: 60,3% is between 15-49 years of age; 65,4% presents reactional episodes during treatment, half of these approximatly presented clinic symptons of neuritis, have being treates with prednisona, it was also observed other smaller clinic

  18. Revisões femorais de artroplastias totais do quadril com afrouxamentos assépticos e fraturas periprotéticas: análise de 49 casos tratados com haste de Wagner Femoral revision total hip arthroplasties with aseptic loosening and periprosthetic fractures: analysis of 49 cases treated with Wagner stem

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    Sergio Nogueira Drumond

    2007-07-01

    Full Text Available OBJETIVO: Avaliar 49 quadris em 48 pacientes submetidos a revisão de artroplastia total do quadril usando a haste de Wagner. MÉTODOS: De abril de 1999 a janeiro de 2005, foram tratados 49 quadris em pacientes portadores de afrouxamento femoral (39 quadris ou fratura periprotética do fêmur (10 quadris com revisão da artroplastia com a prótese de Wagner. O seguimento médio foi de 35 meses e a média de idade, de 63,4 anos. As revisões do componente femoral foram realizadas em 49 quadris e, simultaneamente, no componente acetabular em 36 quadris. RESULTADOS: A avaliação dos resultados pelo índice de D'Aubignè-Postel-Charnley apresentou melhora estatisticamente significante no pós-operatório em relação ao pré-operatório (p OBJECTIVE: To evaluate 49 hips in 48 patients submitted to revision total hip arthroplasty using Wagner stem. METHODS: From April 1999 to January 2005, 49 hips were treated in patients with femoral loosening (39 hips or periprosthetic fracture of the femur (10 hips with revision arthroplasty using the Wagner prosthesis. Mean follow-up lasted 35 months and mean age was 63.4 years. Revisions of the femoral component were performed in 49 hips, with concomitant acetabular component revision in 36 hips. RESULTS: Results evaluation according to the D'Aubignè-Postel-Charnley index presented a statistically significant improvement in the post-operative period in comparison to the pre-operative period (p < 0.001. The most important problems seen were the high rate of dislocations (three hips and dislocations associated to the deepening of the stem (two hips. The four unsatisfactory results were due to loosening (two hips, infection (one hip, and acetabular loosening (one hip. All of the unsatisfactory results occurred in the group of aseptic loosening, but this finding was not statistically significant (p = 0.569. Restoration of bone stock (radiographic evaluation was seen consistently in most cases, without correlation

  19. Techniques used in the exploration of turbidite reservoirs in a frontier setting - Helland Hansen setting, Voering Basin, offshore Mid Norway

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Ferrer, F.; James, S.D.; Lak, B.; Evans, A.M.

    1998-12-31

    In the 15th Norwegian licensing round there was awarded operation of the Helland Hansen deep water license. Subsurface interpretation commenced towards the end of 1996, following completion of a 1540 km{sup 2} 3-D seismic survey. The main exploration target comprise Turonian to Coniacian turbidite sands within a large fault-bound dip closure. This presentation describes various techniques applied in the exploration of this new turbidite play, with emphasis on the study of the reservoir potential. A methodology of integrated analysis is presented. Through these efforts, a greater understanding of the lithological and depositional models in this non-calibrated area has progressively been achieved. 5 refs., 11 figs.

  20. An??lise da implanta????o do programa de elimina????o da hansen??ase em Manaus

    OpenAIRE

    2005-01-01

    Hansen??ase ?? uma doen??a infecto-contagiosa cr??nica causada pelo Mycobacterium leprae, atinge a pele e os nervos, quando n??o diagnosticada e tratada precocemente pode causar incapacidades f??sicas graves. O contagio ocorre atrav??s do contato entre pessoas sadias com casos contagiantes. Hoje a doen??a ?? de f??cil diagn??stico e tratamento. Os esquemas de Poliquimioterapia da Organiza????o Mundial de Sa??de levam a cura em per??odos relativamente curtos, ?? realizado em regime ambulatoria...

  1. Hansen versus Neisser: controvérsias científicas na 'descoberta' do bacilo da lepra Hansen versus Neisser: scientific controversies over the 'discovery' of the bacillus of leprosy

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    Reinaldo Guilherme Bechler

    2012-09-01

    Full Text Available Analisa o conturbado processo científico que levou à 'descoberta' do bacilo causador da lepra, na Europa, na segunda metade do século XIX, e que envolveu alguns dos principais nomes da ciência médica do período, como Robert Koch, Rudolf Virchow e Armauer Hansen. Compreendida como paradigma científico, tal 'descoberta' será aqui reexaminada historicamente através de fontes primárias ainda pouco trabalhadas na América Latina. Objetiva-se oferecer novos instrumentos de análise e de reflexão para a historiografia das ciências, posto que serão identificados aspectos culturais, sociais e mesmo nacionalistas na construção desse paradigma.This paper analyzes the turbulent scientific process that led to the 'discovery' of the bacillus that causes leprosy, which occurred in Europe in the second half of the nineteenth century and which involved some of the leading names in medical science of the period, such as Robert Koch, Rudolf Virchow and Armauer Hansen. Understood as a scientific paradigm, this 'discovery' is reexamined here based on primary sources as yet only partially researched in Latin America. The scope of this paper is to provide new instruments for analysis and reflection for the historiography of the sciences, as the cultural, social and even nationalist aspects are identified in the construction of this paradigm.

  2. Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City.

    Science.gov (United States)

    Lobo, A C; Pai, R R; Gautam, K; Kuruvila, M

    2014-01-01

    Hansen's Disease (HD) presents itself in different forms depending on the individual's immune status, and based on this Ridley-Jopling classified the disease into five sub-groups. The aim of this study was to evaluate the role of histopathology and bacteriological index (BI) in accurate staging of HD with clinical correlation. Fifty HD patients with clinical diagnosis confirmed by histopathology were included. Patients in reaction and on treatment were excluded. Case records and histopathological slides were viewed and BI was recorded. In 10/50 cases, a diagnosis of HD was made or suspected, but were not clinically classified. In these, histopathology proved useful in diagnosis and classification. Indeterminate HD was the most common histopathological diagnosis (6 cases). The remaining 40 patients, were clinically classified using the Ridley-Jopling classification, as Indeterminate Leprosy (IL) in 10/40 (25%), Tuberculoid Leprosy (TT) 5/40 (12.5%), Borderline Tuberculoid (BT) 16/40 (40%), Borderline Lepromatous (BL) 4/40 (10%) and Lepromatous Leprosy (LL) 5 (12.5%). HD was common in males with male to female ratio of 1.66:1 and affected the younger individuals (maximum in 21 to 30 years). On histopathology BT was the most common type (40%) followed by IL (27.5%), BL (12.5%), TT (10%) and LL (10%). No case of Mid-Borderline (BB) type was diagnosed clinically or histopathologically. Overall concordance between clinical and histopathological diagnosis was 65% (26/40 cases) and for each type was IL = 80%, TT = 20%, BT = 75%, BL = 50% and LL = 60%. Where classification seemed difficult as in cases of BT and BL, II played an important role. The overall concordance between clinical classification and histopathological diagnosis of DO is 65% in this study. Th *discordance that is observed is between BT and TT, the paucibacillary type and BL andILL the multibacillary type and hence the treatment is not affected. Overall, IL was a common diagnosis on histopathology in this

  3. [Cement-free diaphyseal fixation principle for hip shaft exchange in large bone defects--analysis of 12 years experience with the Wagner revision shaft].

    Science.gov (United States)

    Böhm, P; Bischel, O

    2001-01-01

    Considering the increasing incidence of revision for failed total hip arthroplasty, we evaluated if the principle of uncemented diaphyseal fixation which is realised with the Wagner SL revision stem, can solve the technical problems of significant bone loss of the proximal femur and can offer good preconditions for bony restoration in the medium term. A consecutive series of 129 femoral revisions with the Wagner SL revisions stem was evaluated. In 87 cases, the acetabular component was revised simultaneously. The revision was indicated in 97 cases of aseptic loosening, in 13 periprosthetic fractures (12 aseptic and 1 septic hip), in 16 cases of septic loosening and in 3 Girdlestone-hips after chronic deep infection. At the time of revision, the mean age of the patients was 64.9 (36.7-86.3) years. For classification of the preoperative defects, both the classification system proposed by Pak et al. and our own classification system were used. The mean period of time between operation and latest follow-up examination, rerevision, or death of the patient was 5.4 years (0.13-11.7 years). Six revision stems required rerevision because of malpositioning (1), significant subsidence (1), periprosthetic fracture (1), and deep infection (3). The mean Merle d'Aubigné score improved from preoperatively 7.7 points to 14.8 at follow-up. Cumulative survival (end point removal of the stem for any cause) was 94.4 percent at 11.7 years. A clear, good, or excellent bony restoration of the proximal femur was seen in 87.6 percent of the cases. The cumulative survival of the revised acetabular components was 97.7 percent at 11.7 years and for the non-revised cups it was 86.9 percent at 10.9 years. Due to the encouraging results with the Wagner revision stem, the principle of uncemented diaphyseal fixation seems to us to be able to solve most of the technical problems in cases of significant bone loss and obviously offers good preconditions for bony restoration. Our own classification

  4. Os efeitos da hanseníase em homens e mulheres: um estudo de gênero

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    Oliveira Maria Helena Pessini de

    1998-01-01

    Full Text Available Por meio das representações sociais, detectamos diferentes experiências de viver a hanseníase no contexto familiar e individual de uma população constituída por 202 hansenianos (132 homens e 70 mulheres, inscritos no programa de controle e tratamento dos serviços de saúde de Ribeirão Preto. Duas etapas para coletas de informaç��es foram realizadas. Na primeira, os hansenianos responderam a um questionário com perguntas estruturadas; na segunda, foram ouvidos relatos de situações vividas no cotidiano de dez homens e mulheres. Os dados revelaram que a doença mobilizou representações diferentes entre os homens e mulheres nos diferentes grupos sociais. A hanseníase representou um desequilíbrio entre os gêneros, acentuando as desigualdades já existentes no campo sócio-cultural e criando novos problemas responsáveis pelos prejuízos bio-psico-sociais e econômicos, além dos estigmas que pesam sobre os indivíduos. Tais resultados devem reorientar os programas de controle e tratamento, visando à recuperação social dos hansenianos, e também servir de paradigma a novas investigações.

  5. Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen's Disease Seen at a United States Clinic.

    Science.gov (United States)

    Leon, Kristoffer E; Jacob, Jesse T; Franco-Paredes, Carlos; Kozarsky, Phyllis E; Wu, Henry M; Fairley, Jessica K

    2016-03-01

    Background.  Hansen's disease (HD), or leprosy, is uncommon in the United States. We sought to describe the characteristics of patients with HD in a US clinic, including an assessment of delays in diagnosis and HD reactions, which have both been associated with nerve damage. Methods.  A retrospective chart review was conducted on patients seen at an HD clinic in the southern United States between January 1, 2002 and January 31, 2014. Demographic and clinical characteristics were summarized, including delays in diagnosis, frequency of reactions, and other complications including peripheral neuropathy. Results.  Thirty patients were seen during the study time period. The majority of patients were male (73%) and had multibacillary disease (70%). Brazil, Mexico, and the United States were the most frequent of the 14 countries of origin. Hansen's disease "reactions", severe inflammatory complications, were identified among 75% of patients, and nerve damage was present at diagnosis in 36% of patients. The median length of time between symptom onset and diagnosis was long at 12 months (range, 1-96), but no single factor was associated with a delay in diagnosis. Conclusions.  The diagnosis of HD was frequently delayed among patients referred to our US clinic. The high frequency of reactions and neuropathy at diagnosis suggests that further efforts at timely diagnosis and management of this often unrecognized disease is needed to prevent the long-term sequelae associated with irreversible nerve damage.

  6. [Rheumatoid arthritis diagnosis based on the detection of a pulmonary rheumatoid nodule in a patient with Hansen's disease].

    Science.gov (United States)

    Matsui, Yoshinori; Akagawa, Shinobu; Masuda, Kimihiko; Matsui, Hirotoshi; Hebisawa, Akira; Nakajima, Yoshiki

    2010-01-01

    A 77-year-old man with Hansen's disease was referred to our hospital because of a small nodular lesion detected adjacent to the pleura in the right lower lobe (S10) on chest CT. He had lost all ten fingers due to Hansen's disease and was using a prosthetic limb after amputation of the right lower leg. Although the patient had an 11-year history of shoulder and back pain and was suspected of having interstitial pneumonia 6 years previously, no detailed examination had been conducted. Bronchoscopy did not yield a definitive diagnosis, and a lung biopsy was performed under thoracoscopic guidance. Histological examination of the resected nodule with colliquative necrosis revealed palisading granulomas with multinucleated giant cells and plasma cell infiltration with formation of lymphoid follicles. Since serum levels of both anti-MMP3 and anti CCP antibodies were elevated, rheumatoid arthritis (RA) with rheumatoid lung was diagnosed. Therefore, the nodule was considered a rheumatoid nodule. Since diagnosis of rheumatoid arthritis is difficult when lacking characteristic joint manifestations, it is important to include rheumatoid nodules as a differential diagnosis and to measure RA specific autoantibodies, to make a comprehensive diagnosis for non-specific necrotizing granulomas.

  7. Neurolymphomatosis in Primary Cutaneous CD4+ Pleomorphic Small/Medium-sized T-cell Lymphoma Mimicking Hansen's Disease.

    Science.gov (United States)

    Khader, Anza; Vineetha, Mary; George, Mamatha; Manakkad, Shiny Padinjarayil; Balakrishnan, Sunitha; Rajan, Uma

    2017-01-01

    Neurolymphomatosis (NL) refers to nerve infiltration by neurotropic neoplastic cells in the setting of a known or an unknown hematological malignancy. It typically presents as painful or painless peripheral mononeuropathy, mononeuritis multiplex, polyneuropathy, polyradiculopathy, or cranial neuropathy. A 32-year-old male presented with a hyperpigmented hypoesthetic plaque over the anterolateral aspect of the right leg with thickening of the right common peroneal nerve and foot drop clinically diagnosed as Hansen's disease. Biopsy taken from skin showed infiltrates of pleomorphic small and medium sized lymphocytes in the dermis and subcutis. On immunohistochemistry, the cells were positive for CD3, CD4 and negative for CD8, CD20, and CD30. Ultrasonography-guided fine-needle aspiration of the thickened nerve showed infiltrates of atypical lymphoid cells. Based on these findings, a diagnosis of NL in primary cutaneous CD4+ pleomorphic small/medium-sized T-cell lymphoma was made. The disease responded to systemic chemotherapy and localized radiotherapy with no evidence of relapse during 3 years follow-up. NL in primary cutaneous CD4+ pleomorphic small/medium-sized T-cell lymphoma presenting with manifestations redolent of Hansen's disease is not described in available literature. This case also demonstrates the utility of fine needle aspiration of nerve, a minimally invasive procedure in the diagnosis of NL.

  8. Application of Hansen Solubility Parameters to predict drug-nail interactions, which can assist the design of nail medicines.

    Science.gov (United States)

    Hossin, B; Rizi, K; Murdan, S

    2016-05-01

    We hypothesised that Hansen Solubility Parameters (HSPs) can be used to predict drug-nail affinities. Our aims were to: (i) determine the HSPs (δD, δP, δH) of the nail plate, the hoof membrane (a model for the nail plate), and of the drugs terbinafine HCl, amorolfine HCl, ciclopirox olamine and efinaconazole, by measuring their swelling/solubility in organic liquids, (ii) predict nail-drug interactions by comparing drug and nail HSPs, and (iii) evaluate the accuracy of these predictions using literature reports of experimentally-determined affinities of these drugs for keratin, the main constituent of the nail plate and hoof. Many solvents caused no change in the mass of nail plates, a few solvents deswelled the nail, while others swelled the nail to varying extents. Fingernail and toenail HSPs were almost the same, while hoof HSPs were similar, except for a slightly lower δP. High nail-terbinafine HCl, nail-amorolfine HCl and nail-ciclopirox olamine affinities, and low nail-efinaconazole affinities were then predicted, and found to accurately match experimental reports of these drugs' affinities to keratin. We therefore propose that drug and nail Hansen Solubility Parameters may be used to predict drug-nail interactions, and that these results can assist in the design of drugs for the treatment of nail diseases, such as onychomycosis and psoriasis. To our knowledge, this is the first report of the application of HSPs in ungual research.

  9. Atuação do enfermeiro no controle epidemiológico da hanseníase

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    Sara Augusta dos Santos

    1992-09-01

    Full Text Available Analisou-se seníase, na Seção de Dermatologia Sanitária do Hospital Universitário Pedro Ernesto, UERJ. Pretendeu-se alcançar três objetivos entre eles comparar a qualidade do controle epidemiológico dos casos novos de hanseníase em registro ativo de 1986, com os mesmos casos relativos ao período de 1987. Aplicou-se o método descritivo e análise de documentos dos prontuários desses clientes. Utilizou-se um formulário com questões de múltipla escolha e preenchimento de claros, totalizando 27 itens. Constatou-se que o enfermeiro interfere nas variáveis: exames para firmar diagnóstico, exames de contatos e educação para saúde, contribuindo para a melhoria da qualidade assistencial do hanseniano. Conclui-se que há diferença significativa na qualidade do controle epidemiológico da hanseníase entre os grupos constituídos.

  10. Estudio de 124 vástagos femorales de Wagner en cirugía de revisión de la cadera

    OpenAIRE

    2000-01-01

    Se presenta una serie de 124 prótesis de cadera tipo Wagner implantadas entre 1990-1997. Se analiza un grupo de 81 prótesis con un seguimiento mínimo de dos años. Se describe la técnica quirúrgica y se analizan las complicaciones intra y postoperatorias. El resultado hallado indica que se trata de una prótesis versátil en los casos en que existe un gran deterioro de la metáfisis femoral, y que la vía transfemoral constituye una buena técnica tanto para la extracción de la prótesis primaria y ...

  11. Estudio de 124 vástagos femorales de Wagner en cirugía de revisión de la cadera

    OpenAIRE

    Palau, J.; Díez, E. (Emeterio); Carballo, A.; Girvent Montllor, Ramón; Puente, C.

    2000-01-01

    Se presenta una serie de 124 prótesis de cadera tipo Wagner implantadas entre 1990-1997. Se analiza un grupo de 81 prótesis con un seguimiento mínimo de dos años. Se describe la técnica quirúrgica y se analizan las complicaciones intra y postoperatorias. El resultado hallado indica que se trata de una prótesis versátil en los casos en que existe un gran deterioro de la metáfisis femoral, y que la vía transfemoral constituye una buena técnica tanto para la extracción de la prótesis primaria y ...

  12. Physical disabilities resulting from hansen's disease in Vale do Jequitinhonha/State of Minas Gerais, Brazil Desarrollo de incapacidades físicas resultantes de la enfermedad de hansen en el Valle de Jequitiñoña, MG Desenvolvimento de incapacidades físicas decorrentes da hanseníase no Vale do Jequitinhonha, MG

    Directory of Open Access Journals (Sweden)

    Francisco Carlos Félix Lana

    2008-12-01

    Full Text Available Leprosy is potentially debilitating. The present study aims at describing and assessing the occurrence of physical disabilities in cases of leprosy in the population of the Vale do Jequitinhonha/MG, in the period 1998-2006. It is an epidemiological descriptive study and the data were collected from the Leprosy Notification Forms. This information was processed using EPI-INFO and analyzed, based on the indicators recommended by the Ministry of Health and the force of association between variables. Of the 1461 cases notified, 46.2% were diagnosed with some kind of physical disability (12.1% degree II. Of these, 59.1% were male; 96.9% of the people were over 15 years old, and 93.2% were multibacillary (p La lepra, enfermedad de Hansen, es conocida por producir, potencialmente, incapacidades. Se tuvo como objetivo describir y analizar la ocurrencia de incapacidades físicas en los casos de lepra de la población residente en el Valle del Jequitiñoña, MG, en el período de 1998-2006. Se trata de un estudio epidemiológico descriptivo. Los datos fueron recolectados de las Fichas de Notificación de Lepra. Las informaciones fueron procesadas en el software EPI-INFO, analizadas usando como referencia los indicadores recomendados por el Ministerio de la Salud y la fuerza de asociación entre las variables (razón de prevalencias. De los 1.461 casos notificados en el período, 46,2% fueron diagnosticados con alguna incapacidad física (12,1% en el grado II. De esos, 59,1% eran del sexo masculino; 96,9% mayores de 15 años y 93,2% eran multibacilares (valor de pA hanseníase é doença potencialmente incapacitante. Objetivou-se descrever e analisar a ocorrência de incapacidades físicas nos casos de hanseníase da população residente no Vale do Jequitinhonha, MG, no período de 1998-2006. Trata-se de estudo epidemiológico descritivo. Os dados foram coletados das Fichas de Notificação de Hanseníase. As informações foram processadas no software

  13. The rare mantis shrimp Areosquilla indica (Hansen, 1976) (Crustacea, Stomatopoda) from the Great Barrier Reef: first Australian records of the genus and species.

    Science.gov (United States)

    Ahyong, Shane T; Wassenberg, Theodore J

    2015-08-18

    The rare mantis shrimp genus Areosquilla is recorded from Australia for the first time based on nine specimens of A. indica (Hansen, 1926) collected from the Great Barrier Reef. Morphological variation beyond that observed in previous accounts is reported. The present record and other recent discoveries bring the Australian stomatopod fauna to 152 species and 68 genera.

  14. The Function of Scientific and Humanistic Ideologies in the Counseling Profession from the Perspective of Cognitive-Experiential Self-Theory: A Response to Hansen

    Science.gov (United States)

    Suthakaran, V.

    2012-01-01

    In this response, the author addresses Hansen's (2012) call for the counseling profession to substitute science with humanities as its primary ideology. The author uses Epstein's (1994) cognitive-experiential self-theory to show that an equal appreciation for science and humanities is more congruent with a holistic humanistic vision for…

  15. Pure neural leprosy: steroids prevent neuropathy progression Corticosteróides previnem a neuropatia na hanseníase

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    Márcia R. Jardim

    2007-12-01

    Full Text Available Multidrug therapy (MDT, with rifampicin, dapsone, and clofazimine, treats leprosy infection but is insufficient in arresting or preventing the nerve damage that causes impairments and disabilities. This case-series study evaluates the benefits of the combined use of steroids and MDT in preventing nerve damage in patients with pure neural leprosy (PNL. In addition to MDT, 24 patients (88% male aged 20-79 years, median=41 received a daily morning dose of 60 mg prednisone (PDN that was gradually reduced by 10 mg during each of the following 5 months. PNL was clinically diagnosed and confirmed by nerve histopathology or PCR. A low prevalence (8.3% of reaction was observed after release from treatment. However, most of the clinical parameters showed significant improvement; and a reduction of nerve conduction block was observed in 42% of the patients. The administration of full-dose PDN improved the clinical and electrophysiological condition of the PNL patients, contributing to the prevention of further neurological damage.A poliquimioterapia (PQT, com rifampicina, dapsona, e clofazimina, trata a infecção na hanseníase, mas é insuficiente para interromper ou prevenir o comprometimento neurológico que causa as incapacidades e desabilidades, nesta enfermidade. Este estudo de série de casos avalia o benefício do uso combinado de prednisona e PQT na prevenção do dano neurológico em pacientes com a forma neural pura da hanseníase (FNP. Além do PQT, 24 pacientes (88% homens, com idade variando entre 20-79, mediana=41 receberam uma dose diária de 60 mg prednisona que foi reduzida gradualmente na dose de 10 mg durante cada um dos 5 meses subseqüentes. FNP foi diagnosticada clinicamente e confirmada através do estudo histopatológico ou PCR. Baixa prevalência de reação (8,3% foi observada apenas após o final do tratamento. A maioria dos parâmetros clínicos mostrou melhora significativa e redução do bloqueio de condução foi observada

  16. Hanseníase, exclusão e preconceito: histórias de vida de mulheres em Santa Catarina Hansen's disease, exclusion and prejudice: life histories of women at Santa Catarina State

    Directory of Open Access Journals (Sweden)

    Patrícia Vieira Martins

    2010-06-01

    Full Text Available Este artigo consta de notas históricas sobre a hanseníase, desde a descoberta do bacilo até o tratamento realizado nos dias atuais. Busca analisar a percepção de algumas mulheres, ex-pacientes de hanseníase, moradoras do Hospital Santa Teresa, localizado em São Pedro de Alcântara, Santa Catarina, sobre o estigma, preconceito e exclusão que elas sofreram e ainda sofrem nos dias atuais. Utilizamos a história oral de três mulheres para a realização dessa pesquisa e constatamos como a consequência deste tratamento "excludente" ao longo dos anos construiu um certo repúdio em torno da doença. A busca e a afirmação da identidade do sujeito estigmatizado tornou-se uma constante. O modelo de aceitação social almejado e o fato de ser reconhecido como diferente e não discriminado é a grande questão.This article describes historical notes about leprosy, from the discovery of the bacillus to the treatment done today. In this text we try to analyze the perception of some women, former leprosy patients, residents of Santa Teresa Hospital, located in the city of São Pedro de Alcântara, Santa Catarina State, on the stigma, prejudice and exclusion they suffered and still suffer today. We used the oral history of three women for research purposes and we found as a result of this "excluding" treatment over the years, that it built some kind of rejection about the disease. The search and affirmation of the identity of the stigmatized subject has become a constant. The model of social acceptance and the fact of being recognized as different and not discriminated is the main issue.

  17. Desigualdade social, crescimento urbano e hanseníase em Manaus: abordagem espacial Desigualdad social, crecimiento urbano y hanseníasis en Manaus (Norte de Brasil: abordaje espacial Social inequality, urban growth and leprosy in Manaus: a spatial approach

    Directory of Open Access Journals (Sweden)

    Elsia Nascimento Belo Imbiriba

    2009-08-01

    Full Text Available OBJETIVO: Analisar a epidemiologia de hanseníase segundo a distribuição espacial e condições de vida da população. MÉTODOS: Estudo ecológico baseado na espacialização da hanseníase em Manaus (AM, entre 1998 e 2004. Os 4.104 casos obtidos do Sistema de Informações de Agravos de Notificação foram georreferenciados de acordo com a localização dos endereços em 1.536 setores censitários urbanos, por meio de quatro técnicas: correios (73,7% dos endereços encontrados; Programa de Cadastro de Logradouros (7,3%; Programa Saúde da Família (2,1% e folhas de coleta do Instituto Brasileiro de Geografia e Estatística (1,5%. Para cálculo do coeficiente de detecção utilizou a população de 2001. Na análise espacial foi aplicado o método bayesiano empírico local para produzir uma estimativa do risco da hanseníase, suavizando o efeito da flutuação das taxas, quando calculadas para pequenas áreas. Para análise da associação entre espacialização e fatores de risco empregou-se a regressão logística, tendo como variáveis explicativas a ocorrência de casos em menores de 15 anos (indicador de gravidade e o Índice de Carência Social construído a partir das variáveis do Censo 2000. RESULTADOS: O coeficiente de detecção apresentou-se hiperendêmico em 34,0% dos setores e muito alto em 26,7%. A medida de associação (odds ratio referente às variáveis explicativas foi significativa. A combinação de baixa condição de vida e ocorrência em menores de 15 anos foi adotada para identificar as áreas prioritárias para intervenção. CONCLUSÕES: A análise espacial da hanseníase mostrou que a distribuição da doença é heterogênea, atingindo mais intensamente as regiões habitadas por grupos em situação de maior vulnerabilidade.OBJETIVO: Analizar la epidemiología de hanseníasis según la distribución espacial y condiciones de vida de la población. MÉTODOS: Estudio ecológico basado en la especialización de la

  18. Hanseníase: conhecimentos e mudanças na vida das pessoas acometidas Hanses's disease: knowledge and changes in the life of wounded people

    Directory of Open Access Journals (Sweden)

    Joyce Mazza Nunes

    2011-01-01

    Full Text Available A hanseníase é uma doença milenar, caracterizada como problema de saúde pública. Este estudo objetiva averiguar o conhecimento de pessoas com hanseníase sobre sua doença e tratamento e investigar possíveis mudanças na vida, como consequência da doença. Realizamos entrevistas com pessoas em tratamento para hanseníase multibacilar em uma Unidade Básica de Saúde do Município de Sobral (CE, em 2005. Percebemos que o conhecimento sobre a doença é rudimentar, geralmente expresso pela própria experiência, envolta de sentimentos negativos. Alguns portadores manifestaram conhecimentos condizentes com a literatura, adquirido através da Internet, livros e informações de profissionais, amigos e familiares. As principais alterações na vida após o diagnóstico estavam relacionadas ao tratamento medicamentoso, quando alguns relataram melhora dos sintomas e outros, um agravamento, interferindo nas atividades diárias.Hanses's disease is a millenary illness, characterized as a public health issue. This study aims to verify the knowledge of people with Hansen's disease about their problem and its treatment and point out possible changes in their lives as a consequence. We conducted interviews with people in treatment for multi-bacillary Hansen's disease in a Basic Health Unit of Sobral, Ceará State, in 2005. We realized that the knowledge about the disease is elementary, usually expressed by people's own experience, involving negative feelings. Some bearers showed to have appropriate knowledge according to the literature, acquired through the internet, books and information from friends and relatives. The main changes in their lives after the diagnosis was related to the use of medicines, as some people related improvement in their symptoms and others worsening, interfering in their daily activities.

  19. Quality of life of patients with paucibacillary leprosy Qualidade de vida em pacientes com hanseníase paucibacilar

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    Iza Maria Corrêa Bottene

    2012-06-01

    Full Text Available BACKGROUND: Leprosy, an infectious disease caused by Mycobacterium leprae, can affect the skin and the peripheral nervous system and, depending on the level of involvement, it can lead to severe deformities. Leprosy is classified into two major groups: paucibacillary (up to five lesions and multibacillary (more than five lesions. The deformities that appear during the progress of the disease can affect the quality of life. OBJECTIVE: To assess quality of life of patients with paucibacillary leprosy diagnosed and treated early in the outpatients' clinic. METHODS: The Dermatology Life Quality Index questionnaire and ShortForm36 were applied to 49 outpatients undergoing treatment at the Leprosy Multidisciplinary Group of the Hospital das Clínicas of the Faculdade de Medicina of the Universidade de São Paulo. RESULTS: The majority of the patients (63% did not show impairment of the quality of life, according to the results obtained by the Dermatology Life Quality Index questionnaire. In the questionnaire Short Form-36, the scores assessed showed slight impairment of the quality of life. CONCLUSION: On this study, we can conclude that this group of patients, with paucibacillary leprosy, did not show important impairment of the quality of life. Therefore we can conclude that the earlier the diagnosis and the treatment the lesser the influence on the quality of life.FUNDAMENTOS: A hanseníase, doença infecciosa causada pelo Mycobacterium leprae, pode acometer a pele e o sistema nervoso periférico e de acordo com o grau de acometimento, levar a graves deformidades. É classificada em dois grandes grupos: paucibacilar (até cinco lesões e multibacilar (mais de cinco lesões. As deformidades que podem ocorrer durante a evolução da doença levam ao comprometimento da qualidade de vida. OBJETIVO: Avaliar a qualidade de vida nos pacientes com hanseníase, do grupo paucibacilar, diagnosticados e tratados precocemente e em tratamento ambulatorial. M

  20. Isolated case of mucosal histoid Hansen's disease of the nasal cavity in a post-global elimination era.

    Science.gov (United States)

    Swain, Santosh K; Jena, Ajay K; Panda, Maitreyee; Mohapatra, Debahuti; Patro, Nibedita; Sahu, Mahesh C

    2015-01-01

    Histoid Hansen's disease is a rare form of multibacillary leprosy with distinct clinical and histopathological features. This type of leprosy is a variant of lepromatous leprosy with a very high bacterial reserve. Of alarming concern is the discovery of an isolated mucosal histoid leprotic lesion inside the nasal cavity of a patient in the post-global leprosy elimination era. Our case had no history of leprosy or exposure to dapsone/multidrug therapy but had a heavy bacillary index. We are reporting this case to highlight the rarity of mucosal lesions due to histoid leprosy and involvement of the nasal cavity, as well as to create awareness and avoid misdiagnosis. This will help facilitate prompt treatment to minimize the complications and deformities of the patient and prevent its spread throughout the community. Copyright © 2015 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.

  1. Severe form of type 2 reaction in patients of Hansen's disease after withdrawal of thalidomide: case reports.

    Science.gov (United States)

    Rattan, R; Shanker, V; Tegta, G R; Verma, G K

    2009-01-01

    Thalidomide, a racemic glutamic acid analogue, was first developed in 1954 and subsequently marketed in Europe, Australia and Canada as a sedative and anti-emetic. It was approved by the Food and Drug Administration (FDA) in the USA in 1998 for the treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and suppression of the cutaneous manifestations of ENL recurrences. It is a good choice for management in patients who are dependent on corticosteroids. Common side effects of thalidomide are teratogenicity, peripheral neuropathy, sedation and constipation. We report 4 cases of Hansen's disease with recurrent ENL who were adequately managed on thalidomide. On sudden withdrawal of thalidomide, they relapsed with severe type 2 reaction including necrotic ENL.

  2. O processo de adaptação estratégica da Cia. Hansen Industrial, de 1941 a 1981

    OpenAIRE

    Vieira, Adalberto José Tavares

    2000-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Esta dissertação descreve e analisa o processo de adaptação estratégica, possibilitando a compreensão da transformação organizacional da empresa pertencente ao setor de plásticos, a partir da década de 40. É estudado o caso da Cia. Hansen Industrial, no período de 1941 a 1981. Na fundamentação teórica, contempla-se aspectos relativos ao processo de adaptação estratégica, mais especificamente escolha estrat...

  3. Development and Psychometric Evaluation of the Hansen Research Services Matrix Adaptive Test: A Measure of Nonverbal IQ.

    Science.gov (United States)

    Hansen, John A

    2016-10-13

    Assessment of individuals on the autism spectrum often includes a measure of nonverbal IQ. One such measure is the Raven's Standard Progressive Matrices (RSPM). For large research studies with participants distributed nationally it is desirable for assessments to be available online. Because time is a premium, it is ideal that the measure produces accurate scores quickly. The Hansen Research Services Matrix Adaptive Test (HRS-MAT) addresses these needs and with similar psychometric properties of the RSPM. Scores based on the HRS-MAT correlated at r = .81 with those of the RSPM. In adult-child pairs, HRS-MAT scores correlated at approximately r = .50. Details from respondents in a national sample and psychometric properties including reliability and validity are discussed.

  4. Comparative study on dispersion and interfacial properties of single walled carbon nanotube/polymer composites using Hansen solubility parameters.

    Science.gov (United States)

    Ma, Jing; Larsen, Raino Mikael

    2013-02-01

    Dispersion and interfacial strain transfer of single walled carbon nanotubes (SWNTs) are two major challenges for the utilization of SWNTs as reinforcements in polymer composites. Surface modifications could help change the dispersion and interfacial properties. In this study, nanocomposites were fabricated by solution blending 1 wt % SWNTs with various modification (nonmodified, nitric acid functionalized, and amine functionalized SWNTs) and three kinds of polymeric materials (polycarbonate, polyvinylidene fluoride, and epoxy). Chemical compatibilities between SWNTs and solvents or polymers are calculated by the Hansen solubility parameters (HSP) method. The dispersion of the SWNTs in solvents is evaluated by dynamic light scattering. The dispersion of SWNTs in polymers evaluated by a light optical microscope (LOM) generally agrees with the HSP prediction. The strain transfer from the matrix to SWNTs is mainly related to the dispersion, the bundle size, the residual thermal stresses on the sample, and, to lesser degree, the HSP.

  5. Comparative Study on Dispersion and Interfacial Properties of Single Walled Carbon Nanotube/Polymer Composites Using Hansen Solubility Parameters

    DEFF Research Database (Denmark)

    Ma, Jing; Larsen, Mikael

    2013-01-01

    Dispersion and interfacial strain transfer of single walled carbon nanotubes (SWNTs) are two major challenges for the utilization of SWNTs as reinforcements in polymer composites. Surface modifications could help change the dispersion and interfacial properties. In this study, nanocomposites were...... fabricated by solution blending 1 wt % SWNTs with various modification (nonmodified, nitric acid functionalized, and amine functionalized SWNTs) and three kinds of polymeric materials (polycarbonate, polyvinylidene fluoride, and epoxy). Chemical compatibilities between SWNTs and solvents or polymers...... are calculated by the Hansen solubility parameters (HSP) method. The dispersion of the SWNTs in solvents is evaluated by dynamic light scattering. The dispersion of SWNTs in polymers evaluated by a light optical microscope (LOM) generally agrees with the HSP prediction. The strain transfer from the matrix...

  6. An evaluation of the Sinan health information system as used by the Hansen's disease control programme, Pernambuco State, Brazil.

    Science.gov (United States)

    Galvão, Paulo Roberto Silva; Ferreira, Andréa Torres; Maciel, Maria Das Graças Galvão; De Almeida, Rejane Pereira; Hinders, Duane; Schreuder, Pieter A M; Kerr-Pontes, Lígia Regina S

    2008-06-01

    Since the introduction of the national notifiable diseases information system (SINAN) in Pernambuco State, Brazil, in 1994, many problems have been encountered. The aim of this study was to evaluate the SINAN software, quality of data input, the transfer of the computerised data from the municipality to state levels, human resources and other factors associated with the health information system infrastructure (HIS). A cross-sectional study was carried out in Pernambuco state, North-eastern Brazil, in 2005. A sample of health regions and municipalities was chosen. SINAN forms from those municipalities were analysed and the flow of notifications followed from municipal level to the regional and finally to the state. Professionals from health units, district, municipal and regional Hansen's Disease Control Programme (HDCP) and Epidemiological Surveillance System (ESS) coordinators, health secretaries and managers of the municipalities and health regions selected were interviewed. SINAN software is functioning up to expectation. However, at all levels of the health system, serious weaknesses not related to the SINAN software were found, varying from lack of human resources (limited number of staff and staff development), lack of infrastructure (office space, computers, supplies, etc.) to an absence of effective coordination, management and supervision of the HIS. Lack of reliable, complete and timely information, and especially the lack of widespread analysis and use of available information in planning and management of health services were the main weaknesses found. Many areas need urgent attention: the quality of patient examination, recording and reporting, the timely processing of quality data, the coordination and management of disease control programmes, and the use of HIS reports by the health services and health managers. Regular feedback, supportive supervision visits and annual reviews are essential to monitor the system and make sure that essential

  7. Developmental hip dysplasia treated by total hip arthroplasty using a cementless Wagner cone stem in young adult patients with a small physique.

    Science.gov (United States)

    Zhen, Ping; Liu, Jun; Lu, Hao; Chen, Hui; Li, Xusheng; Zhou, Shenghu

    2017-05-15

    Developmental hip dysplasia (DDH) may lead to severe acetabular and femoral abnormalities that can render total hip arthroplasty (THA) challenging, especially in DDH patients with a small physique. Most conventional cemented or cementless femoral components are often difficult to implant in the narrow femoral canal and require slight version correction during surgery. The aim of this study was to present the mid-term results of THA in the treatment of DDH patients with a small physique using a cementless Wagner cone prosthesis (Zimmer®, US). Between January 2006 and March 2010, we retrospectively reviewed 50 patients who were treated at our center. A total of 50 patients (52 hips; 45 women, five men; mean age 32.5 years; range 27 to 38 years) who underwent THA were observed. The mean femoral medullary canal dimension at the isthmus was 7.6 mm (range 6.0 to 8.7). According to the Crowe classification, 19 hips presented dysplasia of grade I, while 33 presented dysplasia of grade II. All patients were treated with THA using a cementless Wagner cone prosthesis. Clinical and radiologic evaluations were performed on all patients. The mean duration of follow-up was 7.7 years (range 5.4 to 10.5). The Harris hip score (HHS) improved from 63 ± 9 (range 55 to 70) pre-operatively to 92 ± 8 (range 88 to 100) at the last follow-up. The HHS at the most recent follow-up was excellent in 66% of patients (34 hips), good in 26% (14 hips), fair in 6% (3 hips), and poor in 2% (1 hip). Radiographic evaluation demonstrated excellent osteointegration of the implants. Stem subsidence was present in three stems, and the range of stem subsidence was 2 mm in two stems (3.9%) and 3 mm in one stem (1.9%). Femoral osteolysis was observed in nine hips (18%) in the proximal zones, and no distal osteolysis was noted. Heterotopic ossification was observed in three hips (5.8%); of these, two were classified as Brooker's grade 1, and one was classified as Brooker's grade 2 at the most

  8. Application of the Maxwell-Wagner-Hanai effective medium theory to the analysis of the interfacial polarization relaxations in conducting composite films

    Energy Technology Data Exchange (ETDEWEB)

    Adohi, B J-P [UFR-SSMT, Universite de Cocody, 22 BP 582 Abidjan 22, Ivory Coast (Cote d' Ivoire); Bouanga, C Vanga; Fatyeyeva, K; Tabellout, M [Laboratoire de Physique de l' Etat Condense, UMR CNRS 6087, Universite du Maine, Avenue Olivier Messiaen, 72085 Le Mans Cedex 9 (France)], E-mail: mohamed.tabellout@univ-lemans.fr

    2009-01-07

    A new approach to explain the interfacial polarization phenomenon in conducting composite films is proposed. HCl-doped poly(ethylene terephthalate) (PET) and polyamide-6 (PA-6) matrices with embedded polyaniline (PANI) particles as filler were investigated and analysed, combining dielectric spectroscopy and AFM electrical images with the effective medium theory analysis. Up to three relaxation peaks attributed to the interfacial polarization phenomena were detected in the studied frequency range (0.1 Hz-1 MHz). The AFM electrical images revealed that the doped PA-6/PANI composite can be modelled as a single-type particle medium and the PET/PANI one as a two-type particle medium. A simple dielectric loss expression was derived from the Maxwell-Wagner-Hanai mixture equation and was applied to the experimental data to identify the interfaces involved in each of the relaxation peaks. The parameter values (permittivity, conductivity, volume fraction of the PANI particles) were found to agree well with the measured one, hence validating the models.

  9. Rare diploid females coexist with rare males: a novel finding in triploid parthenogenetic populations in the psyllid Cacopsylla myrtilli (W. Wagner, 1947) (Hemiptera, Psylloidea) in northern Europe.

    Science.gov (United States)

    Nokkala, C; Kuznetsova, V G; Nokkala, S

    2015-10-01

    Using a cytological approach, diploid females were found coexisting with rare males in triploid apomictic parthenogenetic populations of the psyllid Cacopsylla myrtilli (W. Wagner, 1947) in Norway, Sweden, Finland and northwest Russia. Diploid females were easily distinguished from triploid apomictic females by the presence of 13 chiasmate bivalents instead of 39 univalent chromosomes at metaphase I. Abundance equaled that of males, but the proportion of males and diploid females was significantly greater in high altitude compared with low altitude populations. Males mated with females but showed no mating preference for diploid females. Lack of genuine bisexual reproduction owing to either asynaptic meiosis in males, or rarity of males with normal meiosis, suggests that diploids are produced in every generation by parthenogenetic females as reversals from triploidy, with their production being enhanced by environmental factor(s) associated with high altitude. This is further supported by the observation that within a population the COI haplotype found in rare males was the same as that in parthenogenetic triploid females. Thus, in northern Europe parthenogenesis in C. myrtilli is obligate, geographic parthenogenesis. Bisexual populations of C. myrtilli should be looked for in Central and Southern Europe. From the evolutionary point of view, the presence of males and diploid females with normal meiosis in parthenogenetic populations could be significant as they exhibit the potential to re-evolve either a new sexual species of parthenogenetic ancestry or a new parthenogenetic species by contagious parthenogenesis.

  10. Cost and mortality data of a regional limb salvage and hyperbaric medicine program for Wagner Grade 3 or 4 diabetic foot ulcers.

    Science.gov (United States)

    Eggert, J V; Worth, E R; Van Gils, C C

    2016-01-01

    We obtained costs and mortality data in two retrospective cohorts totaling 159 patients who have diabetes mellitus and onset of a diabetic foot ulcer (DFU). Data were collected from 2005 to 2013, with a follow-up period through September 30, 2014. A total of 106 patients entered an evidence-based limb salvage protocol (LSP) for Wagner Grade 3 or 4 (WG3/4) DFU and intention-to-treat adjunctive hyperbaric oxygen (HBO₂) therapy. A second cohort of 53 patients had a primary lower extremity amputation (LEA), either below the knee (BKA) or above the knee (AKA) and were not part of the LSP. Ninety-six of 106 patients completed the LSP/HBO₂with an average cost of USD $33,100. Eighty-eight of 96 patients (91.7%) who completed the LSP/HBO₂had intact lower extremities at one year. Thirty-four of the 96 patients (35.4%) died during the follow-up period. Costs for a historical cohort of 53 patients having a primary major LEA range from USD $66,300 to USD $73,000. Twenty-five of the 53 patients (47.2%) died. The difference in cost of care and mortality between an LSP with adjunctive HBO₂therapy vs. primary LEA is staggering. We conclude that an aggressive limb salvage program that includes HBO₂ therapy is cost-effective.

  11. Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner's dual-process memory model

    Science.gov (United States)

    Sanderson, David J.; McHugh, Stephen B.; Good, Mark A.; Sprengel, Rolf; Seeburg, Peter H.; Rawlins, J. Nicholas P.; Bannerman, David M.

    2010-01-01

    Genetically modified mice, lacking the GluA1 AMPA receptor subunit, are impaired on spatial working memory tasks, but display normal acquisition of spatial reference memory tasks. One explanation for this dissociation is that working memory, win-shift performance engages a GluA1-dependent, non-associative, short-term memory process through which animals choose relatively novel arms in preference to relatively familiar options. In contrast, spatial reference memory, as exemplified by the Morris water maze task, reflects a GluA1-independent, associative, long-term memory mechanism. These results can be accommodated by Wagner's dual-process model of memory in which short and long-term memory mechanisms exist in parallel and, under certain circumstances, compete with each other. According to our analysis, GluA1−/− mice lack short-term memory for recently experienced spatial stimuli. One consequence of this impairment is that these stimuli should remain surprising and thus be better able to form long-term associative representations. Consistent with this hypothesis, we have recently shown that long-term spatial memory for recently visited locations is enhanced in GluA1−/− mice, despite impairments in hippocampal synaptic plasticity. Taken together, these results support a role for GluA1-containing AMPA receptors in short-term habituation, and in modulating the intensity or perceived salience of stimuli. PMID:20350557

  12. Estimation of rhG-CSF absorption kinetics after subcutaneous administration using a modified Wagner-Nelson method with a nonlinear elimination model.

    Science.gov (United States)

    Hayashi, N; Aso, H; Higashida, M; Kinoshita, H; Ohdo, S; Yukawa, E; Higuchi, S

    2001-05-01

    The clearance of recombinant human granulocyte-colony stimulating factor (rhG-CSF) is known to decrease with dose increase, and to be saturable. The average clearance after intravenous administration will be lower than that after subcutaneous administration. Therefore, the apparent absolute bioavailability with subcutaneous administration calculated from the AUC ratio is expected to be an underestimate. The absorption pharmacokinetics after subcutaneous administration was examined using the results of the bioequivalency study between two rhG-CSF formulations with a dose of 2 microg/kg. The analysis was performed using a modified Wagner-Nelson method with the nonlinear elimination model. The apparent absolute bioavailability for subcutaneous administration was 56.9 and 67.5% for each formulation, and the ratio between them was approximately 120%. The true absolute bioavailability was, however, estimated to be 89.8 and 96.9%, respectively, and the ratio was approximately 108%. The absorption pattern was applied to other doses, and the predicted clearance values for subcutaneous and intravenous administrations were then similar to the values for several doses reported in the literature. The underestimation of bioavailability was around 30%, and the amplification of difference was 2.5 times, from 8 to 20%, because of the nonlinear pharmacokinetics. The neutrophil increases for each formulation were identical, despite the different bioavailabilities. The reason for this is probably that the amount eliminated through the saturable process, which might indicate the amount consumed by the G-CSF receptor, was identical for each formulation.

  13. O diálogo da tradição e da renovação sobre a montagem de Tristão e Isolda de Richard Wagner por Peter Konwitschny

    Directory of Open Access Journals (Sweden)

    Alexandre Sobreira Martins

    2006-12-01

    Full Text Available A presente comunicação busca fazer uma leitura da montagem de Peter Konwitschny do drama musical Tristan und Isolde, do compositor alemão Richard Wagner encenada no Teatro Nacional de Munique durante o Festival de Ópera de Munique de 1998, considerando-o como uma revisão pós-moderna que busca romper com a tradição de encenações wagnerianas, trazendo o conteúdo do drama de Wagner para nosso contexto atual; essa leitura será feita à luz das propostas de Christopher Innes e Artaud sobre a representação teatral e as leituras de Homi Bhabha e Michel Foucault sobre a pós-modernidade.

  14. The influence of increased access to basic healthcare on the trends in Hansen's disease detection rate in Brazil from 1980 to 2006.

    Science.gov (United States)

    Penna, Maria Lucia Fernandes; Oliveira, Maria Leide W; Carmo, Eduardo Hage; Penna, Gerson Oliveira; Temporão, José Gomes

    2008-01-01

    Brazilian Hansen's disease detection rate rose during the 80s and 90s of the 20th century. The Brazilian health system reform happened during the same period. Detection rate is a function of the real incidence of cases and the diagnostic agility of the health system. Coverage of BCG immunization in infants was used as a proxy variable for primary healthcare coverage. A log-normal regression model of detection rate as a function of BCG coverage, time and time square was adjusted to data. The detection rate presents an upward trend throughout the period and with a downturn beginning in 2003. The model showed a statistically significant positive regression coefficient for BCG coverage, suggesting that detection rate behavior reflects the improvement of access to health care. The detection rate began a trend towards decline in 2003, indicating a new phase of Hansen's disease control.

  15. Mal de Hansen, anticorpos antifosfolípides e obstrução das artérias fibulares Leprosy, antiphospholipid antibodies and bilateral fibular arteries obstruction

    Directory of Open Access Journals (Sweden)

    Liz Wallin

    2009-04-01

    Full Text Available Pacientes com Mal de Hansen (MH podem se apresentar com quadro clínico e laboratorial sugestivo de doenças reumáticas, o que exige um exercício cuidadoso de diagnósticos diferenciais. Descreve-se aqui o caso de uma jovem com MH que se apresentou com lesões cutâneas sugestivas de vasculite, obstrução de vasos fibulares, FAN e anticorpos antifosfolípides positivos sem muitos estigmas da doença cutânea, ilustrando essa dificuldade.Patients with Hansen's disease (HD may present themselves with clinical and laboratorial features that resemble rheumatic disorders. This requires a careful exercise of differential diagnosis. We describe here a case of a young woman with HD that presented with vasculitic like lesions, fibular vessels obstruction, ANA and antiphospholipid antibodies without typical signs of cutaneous disease, illustrating this clinical difficulty.

  16. [Hansen's disease in Maranhão in the 1930s: on the way to Colônia do Bonfim].

    Science.gov (United States)

    Leandro, José Augusto

    2009-01-01

    Some aspects of Hansen's disease and the health policy for those having it in Maranhão in the 1930s are pointed out. The resolution of the disease in that state followed the precept imposed by the centralizing national health policies developed in the Vargas period: greater sanitary vigilance of those having the disease and the construction of a compulsory isolation colony for the contagiously ill largely characterized the decade regarding the prophylaxis of what was then called leprosy. The discourses of Achilles Lisboa, the doctor who best expressed this period, are highlighted here, since they contributed to aggressively mold the public policies of exclusion directed to those having Hansen's disease in Maranhão.

  17. “拯救”瓦格纳——尼采《瓦格纳事件》疏解%Save Wagner——Areading of Nietzsche's the Case of Wagner

    Institute of Scientific and Technical Information of China (English)

    郭熙明

    2011-01-01

    This article is a reading of Nietzsche's the Case of Wagner,dealing with the relationship of Nietzsche and Wagner.In this book,Nietzsche regarded Wagner not only as a decadent patient,but also as an sign of decadent sickness prevailing over the whole west world.To cure this decadent sickness,Wagner sought treatment to the love and salvation of Christianity;however,Nietzsche thought Wagner's effort must destory the noble music and arts;corresponding with it,Nietzsche took himself as a simple of recovery from the decadent sickness,declaring there was another salvation in classic noblility and cruelty.%本文以疏解《瓦格纳事件》为纲要,对尼采和瓦格纳的关系进行了一次清理。尼采既把瓦格纳看作"颓废"的病人,还把他看作是席卷整个西方的"颓废"疾病之征兆;为了疗治"颓废"疾病,瓦格纳向基督教的"爱"与"拯救"寻求药方,尼采对此大加攻伐,认为其结果势必毁灭"高贵"的艺术和音乐;与之相应,尼采以自己摆脱"颓废"的经历为例,认为在古典的"高贵"和"残酷"中还有另一种"拯救"。

  18. Tendências da hanseníase no Tocantins, um estado hiperendêmico do Norte do Brasil, 2001-2012

    Directory of Open Access Journals (Sweden)

    Lorena Dias Monteiro

    2015-05-01

    Full Text Available A hanseníase é hiperendêmica no Estado do Tocantins, Brasil. O objetivo do estudo foi analisar as tendências dos indicadores da hanseníase no Tocantins em 2001-2012. Análise de dados advindos do Sistema de Informação de Agravos de Notificação (SINAN. Incluíram-se casos novos de residentes no Tocantins. Calcularam-se os indicadores da hanseníase e analisaram-se as tendências temporais por meio de regressão polinomial. Houve tendência significativa e decrescente para a detecção geral (R2 = 0,40; p 0,05, detecção de casos com grau 2 de incapacidade física (R2 = 0,37; p > 0,05 e proporção de casos com grau 2 (R2 = 0,49; p > 0,05. Houve aumento significativo para a proporção de casos com grau 1 de incapacidade (R2 = 0,82; p < 0,05 e proporção de casos multibacilares (R2 = 0,81; p < 0,05. O Tocantins apresenta regiões com alta transmissão e diagnóstico tardio da hanseníase, apontando a expansão da doença de forma heterogênea na análise temporal.

  19. Amiloidose e insuficiência renal crônica terminal associada à hanseníase Amyloidosis and end-stage renal disease associated with leprosy

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    Geraldo Bezerra da Silva Júnior

    2010-08-01

    Full Text Available O envolvimento renal na hanseníase é diverso, incluindo glomerulonefrites, amiloidose e nefrite túbulo-intersticial. Um homem de 58 anos foi admitido com edema de membros inferiores e dispnéia. Na admissão, havia retenção de escórias nitrogenadas, anemia, hipercalemia e acidose metabólica, com necessidade de hemodiálise. Referia história de hanseníase virchoviana. Foi realizada biopsia renal, compatível com amiloidose. O paciente evoluiu estável, sem recuperação da função renal, permanecendo em tratamento hemodialítico. A hanseníase deve ser investigada em todo paciente com perda de função renal, sobretudo naqueles que apresentam lesões cutâneas ou outras manifestações sugestivas de hanseníase.Renal involvement in leprosy includes glomerulonephritis, amyloidosis and tubulointerstitial nephritis. A 58-year-old man was admitted with complaints of lower limb edema and dyspnea. At admission, nitrogen retention, anemia, hyperkalemia and metabolic acidosis were observed, requiring hemodialysis. The patient had a history of lepromatous leprosy. A renal biopsy was performed that was compatible with amyloidosis. The patient had a stable outcome, but without renal function recovery and remained on regular hemodialysis. Leprosy should be investigated in every patient with renal function loss, particularly in those with cutaneous lesions or other manifestations suggestive of leprosy.

  20. Integrated Weber and Lauge-Hansen classification of ankle injuries%踝关节损伤Weber与Lauge-Hansen综合分型分度读片法

    Institute of Scientific and Technical Information of China (English)

    刘经武; 谭利华; 田雨; 刘翠丽; 屈长征; 高劲松

    2014-01-01

    目的:介绍Danis-Weber与Lauge-Hansen综合分型分度法对踝关节损伤平片诊断的应用。方法:应用Danis-Weber与Lauge-Hansen综合分型分度法对287例踝关节创伤的平片重新读片,总结综合分型分度法对踝关节骨折与韧带损伤的诊断价值。结果:287例踝关节损伤照片常规平片共报告骨折343处,韧带损伤176处,应用综合分型分度法读片新发现骨折19处,新发现韧带损伤36处。结论:应用Danis-Weber与Large-Hansen综合分型分度读片法有利于提高影像学医师对踝关节损伤平片诊断的病变发现率。%To intrduce the integrated Danis-Weber and Lauge-Hansen classification of ankle injuries Methods:287 digital ra-diographies with ankle injuries were reviewed and sorted again with integrated Weber and Lauge -Hansen classification.Results:343 fractures and 176 ligamental injuries were found on the conventional ankle digital radiographic reports, and other 19 fractures and 36 ligamental injuries were confirmed with integrated Weber and Lauge-Hansen classification.Conclusion:It would increase the findings of the fractures and ligamen-tal injuries of the ankle joint when the imaging doctors report the injuries with the integrated Weber and Lauge-Hansen classification.

  1. Application of VCS 920+ in Hansen Expander Control System%VCS920+在汉莎发泡机控制系统的应用

    Institute of Scientific and Technical Information of China (English)

    凌时雨

    2001-01-01

    主要介绍使用VCS920+可编程调节器替代进口TELEPERM D型调节器(德国),及其在汉莎发泡机控制系统的应用。%The main idea in this paper is discussing how to replace the foreign TELEPERMD controller with VCS 920+ PLC and its applicaton in Hansen expander control system.

  2. Perfil clínico-epidemiológico da hanseníase em menores de 15 anos no município de Juazeiro-BA

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    Igara Cavalcanti Feitosa Luna

    2013-06-01

    Full Text Available Objetivo: Descrever o perfil epidemiológico e clínico dos casos novos de hanseníase em menores de 15 anos notificados à Secretaria Municipal de Saúde (SMS de Juazeiro-BA, no período de 2001 a 2010. Métodos: Trata-se de um estudo quantitativo, de natureza exploratória e descritiva, realizado a partir da análise dos dados contidos no Sistema de Informação de Agravos de Notificação (SINAN municipal. Resultados: Os resultados mostraram que145 (7,94% casos novos de hanseníase ocorreram em menores de 15 anos. Verificaram-se taxas de detecção altas para essa faixa etária, com predominância no sexo feminino (n=81; 55,86% e maior acometimento na faixa etária entre 10 e 14 anos (n=85; 58,62%. As formas paucibacilares (n=107; 74,48% da doença predominaram sobre as formas multibacilares (n=37; 25,52%, sendo a forma clínica tuberculoide (n=80; 55,17% a mais prevalente. As incapacidades atingiram 18 (12,41% dos pacientes avaliados no diagnóstico e 15 (10,34% na alta. Uma grande parte de casos (n=58; 40,07% deixou de ser avaliada ou foi ignorada. Conclusão: O perfil epidemiológico e clínico da ocorrência de casos novos de hanseníase no município de Juazeiro-BA evidenciou que os coeficientes de detecção geral de hanseníase e em menores de 15 anos se mantiveram em nível hiperendêmico no período avaliado.

  3. Partial solubility parameters of lactose, mannitol and saccharose using the modified extended Hansen method and evaporation light scattering detection.

    Science.gov (United States)

    Peña, M A; Daali, Y; Barra, J; Bustamante, P

    2000-02-01

    The modified extended Hansen method was tested for the first time to determine partial solubility parameters of non-polymeric pharmaceutical excipients. The method was formerly tested with drug molecules, and is based upon a regression analysis of the logarithm of the mole fraction solubility of the solute against the partial solubility parameters of a series of solvents of different chemical classes. Two monosaccharides and one disaccharide (lactose monohydrate, saccharose and mannitol) were chosen. The solubility of these compounds was determined in a series of solvents ranging from nonpolar to polar and covering a wide range of the solubility parameter scale. Sugars do not absorb at the UV-vis region, and the saturated solutions were assayed with a recent chromatographic technique coupled to an evaporative light scattering detector. This technique was suitable to determine the concentration dissolved in most solvents. The modified extended Hansen method provided better results than the original approach. The best model was the four parameter equation, which includes the dispersion delta d, dipolar delta p, acidic delta a and basic delta b partial solubility parameters. The partial solubility parameters obtained, expressed as MPa1/2, were delta d = 17.6, delta p = 28.7, delta h = 19, delta a = 14.5, delta b = 12.4, delta T = 32.8 for lactose, delta d = 16.2, delta p = 24.5, delta h = 14.6, delta a = 8.7, delta b = 12.2, delta T = 32.8 for mannitol and delta d = 17.1, delta p = 18.5, delta h = 13, delta a = 11.3, delta b = 7.6, delta T = 28.4 for saccharose. The high total solubility parameters delta T obtained agree with the polar nature of the sugars. The dispersion parameters delta d are quite similar for the three sugars indicating that the polar delta p and hydrogen bonding parameters (delta h, delta a, delta b) are responsible for the variation in the total solubility parameters delta T obtained, as also found for drugs. The results suggest that the method

  4. Geographic information systems and applied spatial statistics are efficient tools to study Hansen's disease (leprosy) and to determine areas of greater risk of disease.

    Science.gov (United States)

    Queiroz, José Wilton; Dias, Gutemberg H; Nobre, Maurício Lisboa; De Sousa Dias, Márcia C; Araújo, Sérgio F; Barbosa, James D; Bezerra da Trindade-Neto, Pedro; Blackwell, Jenefer M; Jeronimo, Selma M B

    2010-02-01

    Applied Spatial Statistics used in conjunction with geographic information systems (GIS) provide an efficient tool for the surveillance of diseases. Here, using these tools we analyzed the spatial distribution of Hansen's disease in an endemic area in Brazil. A sample of 808 selected from a universe of 1,293 cases was geocoded in Mossoró, Rio Grande do Norte, Brazil. Hansen's disease cases were not distributed randomly within the neighborhoods, with higher detection rates found in more populated districts. Cluster analysis identified two areas of high risk, one with a relative risk of 5.9 (P = 0.001) and the other 6.5 (P = 0.001). A significant relationship between the geographic distribution of disease and the social economic variables indicative of poverty was observed. Our study shows that the combination of GIS and spatial analysis can identify clustering of transmissible disease, such as Hansen's disease, pointing to areas where intervention efforts can be targeted to control disease.

  5. Hanseníase históide de localização restrita Histoid leprosy of restricted location

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    Antônio Pedro Mendes Schettini

    2008-10-01

    Full Text Available A hanseníase permanece importante problema de saúde pública, e os técnicos de unidades básicas de saúde devem estar capacitados para reconhecer as diversas formas de apresentação clínica da doença. Relata-se caso de paciente com lesões pouco habituais, cujo diagnóstico foi importante por se tratar de doente multibacilar, principal elo da cadeia de transmissão da doença. O diagnóstico e tratamento oportuno desses casos contribuem para atingir as metas de eliminação da doença no país.Leprosy remains a public health problem in Brazil. Every health professional at the primary health care level should be able to detect all presentation forms of leprosy. We report the case of a multibacillary patient with unusual lesions, whose diagnosis was important to interfere in the transmission chain. Diagnosis and adequate treatment contribute to reach the leprosy elimination goal in our country.

  6. [Power of music that moves mind and body--music therapy in the Hansen's disease sanatorium in Japan].

    Science.gov (United States)

    Fukamizu, Yuu; En, Junichiro; Kano, Tatsuo; Arikawa, Isao

    2009-02-01

    Average age of residents living in National sanatorium Hoshizuka-Keiaien where people have past history of Hansen disease is around 80 years old at present, and many of them spend their whole days in watching TV or sleeping almost alone in their rooms. Therefore music therapy was introduced in order to improve their daily activities in our sanatorium. Singing, listening to music, playing the musical instruments, and dancing were performed, either in a group or individually. Reactivation of their brain function such as recollection, sense of unity and relaxation were expected. Improvement of cardiopulmonary function was also expected. Solidarity and relaxed state were observed by being with the other participants in the group therapy. For example, when using musical instruments, some participants with hesitation tried to use their instruments, and had good performance. They seemed to be satisfied and became confident with the musical instruments. Then their confidence and satisfaction activated the group. After the sessions, mutual conversation increased. These processes obtained a synergy effect, which means that a group affects of individuals at first and next alteration of individual behavior influences the group. We could observe a better effect in their motivation and activity in their daily life in the individual therapy. The music therapy was applied to the senior participants by the music therapist in this study. The participants could easily reinforce their mind and body through this therapy. Music therapy will be continued for the improvement of quality of life of residents in the sanatorium.

  7. Interview with a quality leader: Carol Wagner on Washington State Hospital Association (WSHA) and their statewide improvement. Interview by Susan V. White.

    Science.gov (United States)

    Wagner, Carol

    2012-01-01

    Carol Wagner, RN, MBA is the Vice President for Patient Safety at the Washington State Hospital Association (WSHA). She is recognized nationally as an innovative patient safety leader. She led the development of WSHA's Patient Safety Program and Rural Healthcare Quality Network. Under Carol's leadership, the WSHA received the 2010 John Eisenberg Patient Safety and Quality Award for national innovation given by The Joint Commission and the National Quality Forum. The association also received the 2011 Dick Davidson Award for Allied Association Leadership. These national awards are two of the highest honors an organization can receive for patient safety and quality. Through close working relationships with national and state regulatory bodies and professional organizations, Carol designs programs to improve quality and safety in every hospital in Washington State. Under Carol's leadership, all hospitals in Washington participated in the Institute for Healthcare Improvement's (IHI) 5 Million Lives Campaign. The effort led to implementation of the largest number of rapid response teams in a geographic area. Carol also created the first statewide learning collaborative to reduce hospital-acquired infections. Carol is a registered nurse with an MBA focusing on finance and operations. She worked clinically in a variety of settings, provided leadership as a nursing administrator, and transitioned to lead hospital strategic planning, budgeting, and cost accounting. She studied management and system change at The Wharton School at the University of Pennsylvania. Her quality training was with Dr. W. Edwards Deming and at Intermountain Health Care with Dr. Brent James. Her experience includes work in for-profit and not-for-profit environments and supporting community, tertiary, and academic medical centers. This includes Huntington Hospital in Pasadena, California and a national for-profit hospital system with more than 100 hospitals. © 2011 National Association for

  8. Un hito en la legislación laboral estadounidense : la Ley Nacional de Relaciones Laborales o la Ley Wagner (1935

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    María Luz Arroyo Vázquez

    2002-01-01

    Full Text Available Durante el New Deal, la legislación laboral adquiere una especial importancia política. Este artículo aborda uno de los principales hitos legislativos sindicales en los Estados Unidos: la ley nacional de relaciones laborales o ley Wagner Atiora bien, mientras que el título de la ley nos incita a pensar en un ámbito extenso de regulación de las relaciones entre patronos y trabajadores, ésta se limita a proteger y garantizar la libertad de sindicarse, el proceso de la negociación colectiva y el derecho a la huelga. En este ensayo se analizan los antecedentes, el desarrollo, los objetivos, y el impacto que tiene esta ley en el mundo laboral estadounidense. Finalmente, se incluye una reflexión sobre la visión que presenta la prensa española coetánea sobre esta medida.During the New Deal, labor legislation acquires a special political importance. This article tackies one oí the main legislative landmarks in the New Deal: the National Labor Relations Act. However, whereas the title oí the law leads us to think of a very extended sphere in the regulation of the relationship between employers and workers, the law is limited to protecting and guaranteeing the freedom to enter a unión, the process of collective bargaining and the right to go on strike. This essay analyses the background, the development, the objectives, and the impact that this law has on the American worid of labor. Finally, a reflection on the visión presented by the coetaneous Spanish press upon this measure is included.

  9. The Maastricht-Duke bridge: An era of mentoring in clinical research - A model for mentoring in clinical research - A tribute to Dr. Galen Wagner.

    Science.gov (United States)

    Meijs, Loek; Zusterzeel, Robbert; Wellens, Hein Jj; Gorgels, Anton Pm

    With the passing of Dr. Galen Wagner, an exceptional collaboration between Maastricht University Medical Center, The Netherlands, and Duke Clinical Research Institute, USA, has come to an end. This article focuses on the background of what Galen coined the Maastricht-Duke bridge (MD-bridge), its merits, limitations and development throughout the years, and his special role. Between 2004 and 2015, 23 Maastricht University medical students and post-graduate students were enrolled in the 4-month research elective, mentored by Galen and the Maastricht co-mentor. They were asked to complete a survey about their MD-bridge experience. Sixteen out of the 23 students responded. None but 1 participant had prior research experience. Following their MD bridge-program most participants published 1 or more manuscripts and/or presented their research in an international setting. They felt they had full responsibility as a leader of their project with all participants developing meaningful skills useful in their current job. Fourteen out of 16 would recommend the MD-bridge experience to others. Participants considered the program of great value for their personal growth and independence, giving a feeling of achievement. In addition, for some participants it led to careers in foreign countries including medical practice and research, or obtaining PhDs. With Galen's impressive career of mentoring students, including the 23 MD-bridge participants, he has left behind an amazing concept of self-development in research and personal life. The successes of the MD-bridge prove that it is possible for students to be young investigators during or just after medical school with the potential to contribute to developing meaningful skills and noteworthy careers. Collaborations between international universities, such as the MD-bridge, are feasible and should be embraced by other institutions. Published by Elsevier Inc.

  10. Preoperative medical treatment in patients undergoing diabetic foot surgery with a Wagner Grade-3 or higher ulcer: a retrospective analysis of 52 patients

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    Murat Korkmaz

    2012-08-01

    Full Text Available Diabetic foot ulcers (DFU are one of the most important complications in people with diabetes mellitus. The present study was aimed to retrospectively review the efficacy of at least 1-week medical treatment before any surgical intervention in patients with Grade-3 and higher DFU according to Wagner's classification. A total of 52 patients (36 males and 16 females hospitalized and treated between June 2006 and February 2009 and had initially received therapeutic treatment (local wound care, antibiotic therapy and blood glucose regulation for a period of at least 1 week were included in the study. The level of amputation, rates of reulceration and mortality in both groups were recorded in the following period of 2 years. Group 1 (did not respond to preoperative medical intervention included 16 patients where a surgical debridement, flap or skin graft surgery was performed in 2 (12.5% patients, major amputation was performed in another 2 (12.5% patients and minor amputation was performed in the remaining 12 (75% patients. Of 36 patients in Group 2 (did respond to preoperative medical intervention, 5 (13.9% patients underwent the surgical debridement, flap or skin graft surgery, 8 (22.2% patients had a major amputation and the remaining 23 (63.9% patients lead to a minor amputation. The ulcer recurrence and mortality rates were obtained as 2 (12.5% and 2 (12.5% in Group 1 and 2 (5.6% and 1 (2.8% in Group 2, respectively. Despite the lower rates of ulcer recurrence and mortality in patients having adequate responses to initial treatment before surgical procedures were performed, no statistically significant difference was observed between the 2 groups. In addition, there was no statistically significant difference between the levels of amputation in both groups.

  11. Validação do questionário de avaliação funcional das mãos em hanseníase

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    Telma Leonel Ferreira

    2012-06-01

    Full Text Available OBJETIVO: Validar as propriedades psicométricas do questionário de avaliação funcional das mãos em hanseníase. MÉTODOS: Estudo realizado com amostra de conveniência de 101 pacientes consecutivos em Brasília, DF, de junho de 2008 a julho de 2009. As pessoas eram adultas afetadas pela hanseníase, com comprometimento nos nervos ulnar, mediano e radial. Foi analisada a reprodutibilidade interobservadores e intraobservador com entrevistas sucessivas e a validade do constructo com associação entre idade, forma clínica da hanseníase, tempo de lesão do nervo, forças de preensão e pinças realizadas com dinamômetro, teste de sensibilidade realizado com monofilamentos de Semmes-Weinstein e avaliação da habilidade manual, utilizando o teste de função manual de Jebsen. Calcularam-se os valores do índice kappa ponderado e construiu-se um gráfico Bland-Altman para avaliar a reprodutibilidade do instrumento. Para a consistência interna, utilizou-se o coeficiente alfa de Cronbach. Foi calculado o coeficiente de correlação de Pearson e usado modelo de regressão múltipla. RESULTADOS: Os valores de kappa ponderado para as avaliações interobservadores e intraobservador variaram de 0,86 a 0,97 e de 0,85 a 0,97, respectivamente. O valor do coeficiente alfa de Cronbach foi de 0,967. O coeficiente de correlação de Pearson mostrou associação (p < 0,001 entre tempo de lesão do nervo, forças de preensão e pinças, sensibilidade cutânea e escore médio do teste de Jebsen. O escore médio do questionário de avaliação funcional das mãos em hanseníase associou-se com classificação operacional da hanseníase, tempo de lesão do nervo, força de preensão, sensibilidade cutânea e habilidade manual (p < 0,0001 para o conjunto do modelo. CONCLUSÕES: O questionário de avaliação funcional das mãos em hanseníase apresenta reprodutibilidade quase perfeita interobservadores e intraobservador, alta consistência interna e correla

  12. SBD-RESP na busca ativa de casos de hanseníase SBD-RESP in active search for leprosy cases

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    Joel Carlos Lastória

    2011-06-01

    Full Text Available FUNDAMENTOS: A Sociedade Brasileira de Dermatologia Regional do Estado de São Paulo (SBD-RESP, apoiada pela Fundação Paulista Contra a Hanseníase, e em ação conjunta com os Serviços de Dermatologia do estado de São Paulo, credenciados pela Sociedade Brasileira de Dermatologia, lançou a campanha "SBD-RESP na Busca Ativa de Casos de Hanseníase". OBJETIVOS: Auxiliar o Programa Nacional de Controle da Hanseníase no controle da doença. MÉTODO: Todos os Serviços de Dermatologia do estado de São Paulo, credenciados pela Sociedade Brasileira de Dermatologia, foram convidados e os 17 que participaram receberam uma planilha de dados e modelos de materiais informativos sobre a doença. A campanha foi realizada entre os meses de maio e julho de 2010. Ao término do período, cada serviço encaminhou a planilha de dados para análise estatística. RESULTADOS: Foram examinadas 1718 pessoas e diagnosticados, no total, 90 casos de hanseníase, a maioria do gênero masculino e da cor branca, com percentuais semelhantes de multibacilares e de paucibacilares. Doze por cento apresentavam história familiar de hanseníase. O maior número de casos detectados foi na capital, seguido, no interior, pela região de Presidente Prudente. O índice de detecção em menores de 15 anos foi 4%. CONCLUSÕES: Os resultados da campanha mostram a importância desta iniciativa da SBD-RESP. Sugere-se que ações semelhantes sejam repetidas e que se estendam a outras regionais da Sociedade Brasileira de DermatologiaBACKGROUND: The Brazilian Society of Dermatology of the State of Sao Paulo (SBD-RESP, supported by the Sao Paulo State Foundation Against Leprosy and acting jointly with Sao Paulo State Services of Dermatology, accredited by the Brazilian Society of Dermatology, launched the campaign "SBD-RESP in active search for leprosy cases". OBJECTIVES: To assist the National Leprosy Control Program in eliminating Hansen's disease. METHODS: All of the Sao Paulo State

  13. Significados e usos de materiais educativos sobre hanseníase segundo profissionais de saúde pública do Município do Rio de Janeiro, Brasil Meanings and use of educational materials on Hansen disease according to public health officials in the Municipality of Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Adriana Kelly-Santos

    2009-04-01

    Full Text Available O artigo objetiva refletir sobre os processos comunicativos de Programas de Controle de Hanseníase (PCH do Sistema Único de Saúde (SUS, por meio da análise da recepção de materiais educativos por profissionais de dois serviços de saúde pública no Rio de Janeiro, Brasil. O trabalho discute em que medida a análise de impressos favorece a negociação dos sentidos e das práticas sobre hanseníase vigentes nos PCH. Foram analisados 38 materiais produzidos entre 1993 a 2005, por instituições governamentais e não-governamentais e realizados dois grupos focais com profissionais atuantes no PCH. Durante os grupos focais 6 materiais foram examinados. Os resultados revelaram a verticalidade e fragmentação nos processos comunicativos, expressas pela: ênfase em campanhas, produção centralizada, homogeneização dos públicos e conteúdos e privilégio dado ao saber biomédico. As atividades horizontais e participativas não eram comuns. Foi identificada uma lacuna entre a institucionalização do discurso da hanseníase, como alternativa à terminologia da lepra, e a sua circulação e consumo entre os diferentes atores sociais.This article reflects on the communications processes in the Hansen Disease Control Programs under the Unified National Health System (SUS in Brazil, analyzing how professionals at two public health services in Rio de Janeiro perceive the educational materials on the disease. The article discusses how analysis of printed materials favors negotiation of prevailing meanings and practices on Hansen disease in the programs. Thirty-eight different educational materials were analyzed (produced from 1993 to 2005 by governmental and nongovernmental institutions through two focus groups with program staff. Six materials were examined during the focus groups. The findings showed the communications processes are vertical and fragmented, with an emphasis on campaigns, centralized production of materials, homogenization of

  14. Achieving concentrated graphene dispersions in water/acetone mixtures by the strategy of tailoring Hansen solubility parameters

    Science.gov (United States)

    Yi, Min; Shen, Zhigang; Zhang, Xiaojing; Ma, Shulin

    2013-01-01

    Although exfoliating graphite to give graphene paves a new way for graphene preparation, a general strategy of low-boiling-point solvents and high graphene concentration is still highly required. In this study, using the strategy of tailoring Hansen solubility parameters (HSP), a method based on exfoliation of graphite in water/acetone mixtures is demonstrated to achieve concentrated graphene dispersions. It is found that in the scope of blending two mediocre solvents, tailoring the HSP of water/acetone mixtures to approach the HSP of graphene could yield graphene dispersions at a high concentration of up to 0.21 mg ml-1. The experimentally determined optimum composition of the mixtures occurs at an acetone mass fraction of ˜75%. The trend of concentration varying with mixture compositions could be well predicated by the model, which relates the concentration to the mixing enthalpy within the scope of HSP theory. The resultant dispersion is highly stabilized. Atomic force microscopic statistical analysis shows that up to ˜50% of the prepared nanosheets are less than 1 nm thick after 4 h sonication and 114g centrifugation. Analyses based on diverse characterizations indicate the graphene sheets to be largely free of basal plane defects and oxidation. The filtered films are also investigated in terms of their electrical and optical properties to show reasonable conductivity and transparency. The strategy of tailoring HSP, which can be easily extended to various solvent systems, and water/acetone mixtures here, extends the scope for large-scale production of graphene in low-boiling-point solutions.

  15. Freqüência das alterações oftalmológicas em pacientes com hanseníase residentes em hospital-colônia Frequency of ocular changes in patients with Hansen's disease living in a colony hospital

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    Francineide Sadala de Souza

    2005-06-01

    Full Text Available OBJETIVOS: Identificar a freqüência das alterações oculares em pacientes hansenianos residentes em hospital-colônia; comprovar a predileção pelo segmento anterior do olho em relação ao posterior. MÉTODOS: Fez-se estudo transversal de 115 olhos de 58 pacientes internados no abrigo João Paulo II, em Marituba - Pará, no período de agosto a outubro de 1999. Os dados epidemiológicos da pesquisa foram obtidos da ficha de cada paciente e de dados colhidos durante o exame oftalmológico. Todos os pacientes estudados estavam curados da hanseníase segundo as normas do Ministério da Saúde. RESULTADOS: Em 114 olhos (99,1% foi observado envolvimento ocular, sendo a maioria (77,2% pertencente à forma virchowiana. Os achados oculares mais freqüentes nos anexos oculares foram a madarose ciliar parcial (70,4% e a madarose superciliar parcial (59,1%. Quanto ao bulbo ocular, o achado mais freqüente relacionado à hanseníase foi a diminuição e/ou ausência de sensibilidade corneana observada em 42,6% dos olhos, seguida da midríase paralítica (16,5% encontrada no pós-operatório dos pacientes submetidos a facectomia, achado ligado intimamente à atrofia de íris (8,7%, comumente observada nestes pacientes. Não foi encontrada nenhuma alteração à fundoscopia que pudesse ser atribuída à hanseníase. CONCLUSÕES: A alta prevalência de alterações do bulbo ocular e anexos em pacientes portadores de hanseníase, principalmente na forma virchowiana, indicam a necessidade da assistência contínua a esses pacientes mesmo após a cura da doença.PURPOSE: To identify the frequency of ocular changes in patients with Hansen's disease, living in a colony hospital; to confirm the predilection for the anterior segment of the eye instead of the posterior segment. METHODS: Transversal study of 115 eyes of 58 in-patients at João Paulo II colony, Marituba - Pará, from August to October 1999. The epidemiologic data of this research were obtained from

  16. Prevalência de olho seco em portadores de hanseníase de um hospital-colônia em Goiânia Prevalence of dry eye in Hansen's disease patients from a colony hospital in Goiânia, Brazil

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    Karys Carvalho Frazão

    2005-08-01

    Full Text Available OBJETIVO: Determinar a prevalência de olho seco em hansenianos do Hospital de Dermatologia Sanitária de Goiânia. MÉTODOS: A amostra do presente estudo incluiu 70 hansenianos, do Hospital de Dermatologia Sanitária de Goiânia, e 30 controles, da Fundação Banco de Olhos de Goiás, ambos localizados em Goiânia-GO. Foram realizados exame oftalmológico e testes de Schirmer I, "break-up time" (BUT e rosa bengala em todos estes indivíduos em uma única avaliação. Para o diagnóstico de olho seco foi considerado o teste de Schirmer I menor ou igual a 5 mm e o rosa bengala grau II ou III, em pelo menos um olho. RESULTADOS: Quarenta e quatro (63,0% hansenianos eram do sexo masculino e 22 (73,3% controles, do sexo feminino (p=0,001. A idade média dos hansenianos foi de 61,1±12,5 anos e no grupo controle, 55,7±9,6 anos. Quinze (21,4% hansenianos e quatro (13,3% controles apresentaram diagnóstico de olho seco (p=0,429. A forma virchowiana (HV (74,2% da hanseníase foi a mais prevalente e o olho seco (66,7% foi mais freqüente nesta forma clínica da doença. CONCLUSÃO: A prevalência de olho seco foi maior no grupo de hansenianos, apesar de não ter havido diferença significativa.PURPOSE: To determine the prevalence of dry eye in Hansen's disease patients from the "Hospital de Dermatologia Sanitária de Goiânia". METHODS: The sample of the present study included 70 patients with Hansen's disease, from the "Hospital de Dermatologia Sanitária de Goiânia", and 30 controls, from the "Fundação Banco de Olhos de Goiás", both located in Goiânia-GO, Brazil. Ophthalmologic examination and Schirmer I, break-up time (BUT and rose Bengal staining tests were carried out for all patients in a single evaluation. For the diagnosis of dry eye the Schirmer I equal or less than 5 mm and rose Bengal grade II or III, in at least one eye were considered. RESULTS: Forty-four (63.0% patients with Hansen's disease were male and 22 (73.3% controls were female

  17. EVALUASI DAN PENGENDALIAN FAKTOR RISIKO KARIES

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    Narlan Sumawinata

    2015-08-01

    Full Text Available Dental caries is a multifactorial disease that it is a preventable one. The assessment and control of the risk factors, therefore, plays a significant role in evading the development of caries. Risk factors include medical and dental history, clinical, radiographic, and laboratory factors. Medical and dental history factors consist of social-economic status of the patients, age, gender, oral hygiene, fluoride exposure, the dietary carbohydrate, civilizaiton, general health, and medicaiton. Clinical factors to be assessed are dental plaque, the susceptible site of the tooth, the existing restoration, and orthodontic appliances. The laboratory factors evaluate the conditions of the saliva i.e. the buffer capacity, flow rate, and the presence of caries-related microorganisms such as mutans streptococci, lactobacilli, or yeast. As caries is caused by three main factors (host, cariogenic substrate, and microflora the control of the above mentioned factors consist of increasing the resistance of the host, evading the cariogenic substrate and microflora, and suppressing the modulator that increasing caries activity.

  18. PERANAN KEBIASAAN MEROKOK TERHADAP INSIDENSI KARIES

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    Widijanto Sudhana

    2015-08-01

    Full Text Available Cigarette smoking has long been suspected to be associated with a variety of oral conditions including dental caries. However, the association between habitual smoking with the caries incidence have to be further elucidated. The caries epidemiological data were reported significantly higher among smokers compared to non-smokers. Further, a retrospective study on the relationship between habitual cigarette smoking and specific pattern of dental decay has been reported that a specific type of decay occurs in term of form, location, and pathology. Although there are still controversial data, in the respect of oral hygiene, plaque index reported greater in smokers, while smokers showed decreased levels of salivary IgA, buffer capacity, and pH when compared with non-smokers. It can be concluded, there are relationship between smoking and the caries incidence indicated by several epidemiological data. However, further biomedical and studies on the influence of smoking on the caries development are still needed.

  19. Hanseníase: a realidade do ser adolescente Lepra: la realidad para el adolescente Leprosy: the reality for the adolescent

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    Keila Maria de Azevedo Ponte

    2005-06-01

    Full Text Available A hanseníase é uma doença contagiosa, estigmatizante, de grande potencial incapacitante, e os adolescentes por estarem numa fase de mudanças e de adaptação, esta doença pode interferir na construção de sua vida. O estudo objetiva caracterizar os adolescentes portadores de hanseníase segundo aspectos sócio-demograficos; realizar análise epidemiológico-operacional da hanseníase; verificar o conhecimento dos adolescentes sobre a hanseníase e as reações manifestadas pelos mesmos após sua descoberta; Identificar as mudanças ocorridas após a doença na vida do adolescente e as dificuldades vivenciadas pelo mesmo após a da doença. Trata-se de uma pesquisa exploratória e descritiva, constituída de 31 adolescentes portadores de hanseníase, assistido pela Estratégia Saúde da Família no Município de Sobral- Ceará. Os resultados sinalizam a necessidade de uma assistência integral e continuada ao adolescente portador de hanseníase, evitando que essa doença provoque mudanças significativas em sua vida, dificultando na construção de sua nova identidade.La lepra es una enfermedad contagiosa, de un gran potencial incapacitante y los adolescentes por estaren viviendo en una fase de cambios e adaptación esta enfermedad puede interferir en la construcción de sus vidas. Esta investigación apunta caracterizar los adolescentes portadores de lepra según aspectos sociales-demográficos; hacer un análisis epidémico-operacional de la enfermedad lepra; verificar el conocimiento de los adolescentes sobre la lepra y las relaciones manifestadas por los mismos después de su descubierta; identificar los cambios ocurridos en la vida del adolescente después de la descubierta de la enfermedad. Tratase de una investigación exploratoria y descriptiva donde participarón 31 adolescentes portadores de lepra ayudados por la Estrategia Salud de la Familia en el municipio de Sobral - Ceará. Los resultados señalan la necesidad de una

  20. Análise epidemiológica da hanseníase em um estado endêmico do nordeste brasileiro

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    Karen Krystine Gonçalves de Brito

    Full Text Available RESUMO Objetivo Caracterizar a tendência, segundo indicadores epidemiológicos e operacionais, de endemia da hanseníase no Estado da Paraíba no período de 2001-2011, com projeções para os anos de 2012-2014. Métodos Estudo epidemiológico de série temporal, retrospectivo e documental, realizado com 10.476 casos notificados de hanseníase, diagnosticados entre 2001-2011, nos 223 municípios do Estado paraibano. Utilizou-se para composição e análise dos resultados dois indicadores epidemiológicos e um indicador operacional além de software estatístico. Resultados Para o coeficiente de detecção anual de casos novos, verificou-se inclinação ascendente entre os anos de 2001 a 2005, com tendência de queda a partir de 2006. Quanto à incapacidade física, visualizou-se variação cíclica, com tendência à inclinação descendente, com classificação considerada de média efetividade. Conclusão Os resultados apontaram continuidade da endemia no Estado, existindo a necessidade de avaliações mais curtas voltadas aos programas e estratégias em saúde utilizadas no combate à hanseníase.

  1. [Hansen's disease-associated disabilities in sanatoria residents. A study of the actual situation in three sanatoria located in the Setouchi area].

    Science.gov (United States)

    Aoki, Yoshinori

    2004-09-01

    Clarification of details of Hansen's disease in Japan is important for obtaining an adequate understanding of the present circumstances regarding control and for formulation of specific suggestions for future measures. The average age of residents in national Hansen's disease sanatoria reached 74.9 in May 2002 and most of these suffer from serious disabilities caused by the disease. In order to implement measures facilitating their return to society or secure living in sanatoria, a proper understanding of the residents' physical situation is essential. Therefore, the present study was conducted of residents suffering from Hansen's disease in Japan. A direct interview was conducted with all 1282 residents of three sanatoria, located in the Setouchi area: Nagashima-aiseien, Oku-komyoen, and Oshima-seishoen. An investigator visited the rooms of the residents, interviewed them using a questionnaire, which consisted of about 100 items including the OPCS scale, and filled out an answer form. The reply rate was 64%. The average age of the residents was found to be 72.8 years, their average age when they entered the sanatoria was 26.0 years, and the average period of residence was 52.4 years. The damage they suffer as a result of the isolation policy is physical, mental, economical and social. That is to say, their entire life is harmed as a direct result of the Leprosy Prevention Law or the Eugenic Protection Law with discrimination in society and negative effects on their families. Their physical condition features serious disabilities in the use of fingers, as well as in walking and seeing caused by peripheral nerve damage. Such disabilities are related to their age and period of residence, and in addition, these in use of their fingers are related to the work which residents were forced to do in sanatoria. The results indicate that patients' physical condition is related to their age, how long they have had the disease and their work in sanatoria. It is clear that

  2. Dielectric Enhancement and Maxwell-Wagner Effect in Polycrystalline BaTiO3/Ba0.2Sr0.8TiO3 Multilayered Thin Films

    Institute of Scientific and Technical Information of China (English)

    葛水兵; 沈明荣; 宁兆元

    2002-01-01

    Polycrystalline BaTiO3/Ba0.2Sr0.sTiO3 multilayer thin films were fabricated by pulsed laser deposition onto Pt/Ti/SiO2/Si substrates with various stacking periodicities. The dielectric constant of the films was obviously enhanced with the decrease of the individual layer thickness, while the dielectric loss was kept at a low level comparable to that of the pure Ba0.6Sr0.4TiO3 thin films. The Maxwell-Wagner model is used to explain the experimental data.

  3. En torno al arte europeo de la segunda mitad del siglo XIX. Aspectos de las relaciones forma–contenido o forma–función en la obra de Lawrence Alma–Tadema, Gottfried Semper y Richard Wagner

    OpenAIRE

    Moreno Dopazo, Ángel

    2011-01-01

    El trabajo se plantea como una reflexión sobre la dificultad actual para apreciar los valores, a menudo denostados, de los ya supuestamente lejanos arte y cultura del siglo XIX. De aquel rico mundo de referentes y asociaciones se destacan aquí las figuras del pintor realista Alma-Tadema, los arquitectos del Ring de Viena, con Semper como singular protagonista, y el músico Richard Wagner. Junto al análisis del complejo universo pictórico del artista holandés afincado en Inglaterra se presenta ...

  4. Insights into organogelation and its kinetics from Hansen solubility parameters. Toward a priori predictions of molecular gelation.

    Science.gov (United States)

    Diehn, Kevin K; Oh, Hyuntaek; Hashemipour, Reza; Weiss, Richard G; Raghavan, Srinivasa R

    2014-04-21

    Many small molecules can self-assemble by non-covalent interactions into fibrous networks and thereby induce gelation of organic liquids. However, no capability currently exists to predict whether a molecule in a given solvent will form a gel, a low-viscosity solution (sol), or an insoluble precipitate. Gelation has been recognized as a phenomenon that reflects a balance between solubility and insolubility; however, the distinction between these regimes has not been quantified in a systematic fashion. In this work, we focus on a well-known gelator, 1,3:2,4-dibenzylidene sorbitol (DBS), and study its self-assembly in various solvents. From these data, we build a framework for DBS gelation based on Hansen solubility parameters (HSPs). While the HSPs for DBS are not known a priori, the HSPs are available for each solvent and they quantify the solvent's ability to interact via dispersion, dipole-dipole, and hydrogen bonding interactions. Using the three HSPs, we construct three-dimensional plots showing regions of solubility (S), slow gelation (SG), instant gelation (IG), and insolubility (I) for DBS in the different solvents at a given temperature and concentration. Our principal finding is that the above regions radiate out as concentric shells: i.e., a central solubility (S) sphere, followed in order by spheres corresponding to SG, IG, and I regions. The distance (R0) from the origin of the central sphere quantifies the incompatibility between DBS and a solvent-the larger this distance, the more incompatible the pair. The elastic modulus of the final gel increases with R0, while the time required for a super-saturated sol to form a gel decreases with R0. Importantly, if R0 is too small, the gels are weak, but if R0 is too large, insolubility occurs-thus, strong gels fall within an optimal window of incompatibility between the gelator and the solvent. Our approach can be used to design organogels of desired strength and gelation time by judicious choice of a

  5. Conhecimento e prática dos enfermeiros sobre hanseníase: ações de controle e eliminação

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    Francisco Feitosa Rodrigues

    2015-04-01

    Full Text Available RESUMO Objetivo: avaliar o conhecimento e a prática de enfermeiros da atenção primária de saúde quanto às ações de controle e eliminação da hanseníase. Método: estudo avaliativo, com abordagem qualitativa, utilizando o Discurso do Sujeito Coletivo, cujos dados foram obtidos por meio de entrevista semiestruturada, realizada com 16 enfermeiros. Resultados: os dados coletados revelaram que os profissionais de saúde possuem conhecimento suficiente sobre a Política Nacional de Controle e Eliminação da Hanseníase (PNCEH e que as principais ações preconizadas foram executadas, porém, a notificação de casos suspeitos ou confirmados e a reinserção social do doente não foram citadas. Conclusão: manter os doentes em tratamento, sobrecarga de trabalho, falta de interdisciplinaridade e tratamento realizado em outros locais fora da comunidade foram dificuldades relatadas pelos profissionais. Os enfermeiros conhecem as ações direcionadas à assistência ao hanseniano, entretanto, o estudo aponta para a necessidade de uma prática mais alinhada ao que preconiza a PNECH.

  6. Vasculite na hanseníase mimetizando doenças reumáticas Vasculitis in leprosy mimicking rheumatic diseases

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    Sandra Lúcia Euzébio Ribeiro

    2007-04-01

    Full Text Available Os autores alertam para o múltiplo espectro de apresentação clínica da hanseníase, destacando as lesões cutâneas necrosantes e manifestações articulares simulando doenças reumáticas, confundindo o diagnóstico e o tratamento correto. Nesses aspectos, são relatados dois casos do sexo feminino com hanseníase virchowiana e dimorfa cujas manifestações iniciais foram de lesões eritêmato-violáceas, necróticas e ulceradas, livedo reticular, oligoartrite, poliartralgias, mialgias e edema de membros inferiores, que mimetizaram algumas doenças reumáticas como o lúpus eritematoso sistêmico e a vasculite sistêmica (poliarterite nodosa.Leprosy has a large spectrum of clinical manifestations, including necrotizing skin lesions and joint complaints that sometimes mimic a primary rheumatic disease, confounding the correct diagnosis and treatment. Herein, the authors report two cases of women with leprosy, respectively virchowian and dimorphic forms, presenting initially with purple-reddish skin lesions, evolving with necrosis and ulceration, livedo reticularis, joint pain, oligoarthritis, myalgia, and leg edema. The differential diagnosis with systemic lupus erythematosus (SLE and systemic vasculitis such as polyarteritis nodosa (PAN is discussed.

  7. Mineviku pantvangid / Vootele Hansen

    Index Scriptorium Estoniae

    Hansen, Vootele, 1962-

    2001-01-01

    Kommunistliku režiimi kuritegelikkusest. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Severnoje Poberezhje, 16. juuni 2001, lk. 2; Meie Maa, 16. juuni 2001, lk. 2; Võrumaa Teataja, 19. juuni 2001, lk. 2; Sakala, 20. juuni 2001, lk. 2; Lääne Elu, 19. juuni 2001, lk. 4

  8. [Hansen disease in Mercosur].

    Science.gov (United States)

    Vazquez, F A; Varela, N N; Antola, M C; Wand-Del-Rey, M L; Leguizamón, O R

    1996-01-01

    In the context of the important changes of a political economic, social and health order upon which the Argentina, Brazil, Paraguay and Uruguay have now embarked in the framework of the commitment undertaken to create instruments for the Common Market of the South America (MERCOSUR), the importance of leprosy for public health in this new region is analysed. In this connection a description is given of the background and reasons which led to the creation of the MERCOSUR Committee for technical cooperation on leprosy, composed of the heads of the national leprosy control programmes of the countries in question, for the purpose of implementing the Protocol of Intention signed by the representatives of the Ministers of member countries, with the object of establishing policies of technical cooperation in activities to control this disease, with a view to attaining the goal proposed by WHO of eliminating leprosy as a public health problem by the year 2000. Using the data contributed by the different programmes, the epidemiological situation existing in this region in December 1995 is outlined, with analysis of certain epidemiological, demographic and operational variables, showing that MERCOSUR has a prevalence of 6.03 per 10,000 population, one of the highest rates in comparison with other WHO regions; a high percentage of cases lost to view (abandons); and a low rate of coverage with multidrug therapy. In this region a total of 33,654 new cases were detected during 1995, of which more than 50% were multibacillary forms, while nearly 10% of them were youngsters of less of 15 years of age. The action carried out jointly among the four countries, the successes achieved and the results to be achieved in the short term are also described.

  9. Eelarvamustest lahti / Katt Hansen

    Index Scriptorium Estoniae

    Hansen, Katt

    2003-01-01

    PÖFFi naistekeskseid mängufilme : taanlase Morten Arnfredi "Õnne tänav", tšehh Michaela Pavlatova "Truudusetud mängud", prantsuse filmid "29 Palms" (Bruno Dumont) ja "Väike Lili" (Claude Miller) ning prantsuse-tuneesia "Satin Rouge" (Raja Amari)

  10. Mineviku pantvangid / Vootele Hansen

    Index Scriptorium Estoniae

    Hansen, Vootele, 1962-

    2001-01-01

    Kommunistliku režiimi kuritegelikkusest. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Severnoje Poberezhje, 16. juuni 2001, lk. 2; Meie Maa, 16. juuni 2001, lk. 2; Võrumaa Teataja, 19. juuni 2001, lk. 2; Sakala, 20. juuni 2001, lk. 2; Lääne Elu, 19. juuni 2001, lk. 4

  11. Contrapontos da história da hanseníase no Brasil: cenários de estigma e confinamento Contrapuntos de la historia de la enfermedad de Hansen en Brasil: escenarios de estigma y confinamiento Counterpoints in the history of Hansen's disease in Brazil: situations of stigma and seclusion

    Directory of Open Access Journals (Sweden)

    Luiz Antonio de Castro Santos

    2008-06-01

    Full Text Available Ao discutir a luta contra a hanseníase no Brasil, em especial em São Paulo e no Maranhão, o trabalho focaliza as múltiplas formas da história institucional e da "cultura de reclusão" dos hansenianos. Critica-se a visão corrente de um cenário único de disciplina e vigilância para, ao contrário, sugerir a existência de cenários cambiantes, marcados por conflitos, negociações e distintas propostas de prevenção ou de combate à doença. O texto aborda as diferentes concepções médicas e "profanas" da lepra, bem como as propostas e práticas de intervenção social no Brasil e, em particular, nos estados de São Paulo e do Maranhão, desde os primeiros tempos da República até as primeiras décadas da Era Vargas. O combate à doença sempre desafiou conceitos e convicções sobre tratamento, propagação, confinamento e regeneração, sob múltiplos significados epidemiológicos, médicos, culturais e sociais, referidos ao estigma da doença, do pecado e da impureza. O texto procura estabelecer alguns cenários brasileiros nos quais se revelam as identidades coletivas deterioradas, a exclusão social e as políticas de confinamento institucional e de regeneração dos doentes.Al discutir la lucha contra la enfermedad de Hansen en Brasil, en especial en San Pablo y en Maranhão, el trabajo enfocará las múltiples formas de la historia institucional y de la "cultura de reclusión" de los hansenianos (leprosos. Se critica la visión corriente de un escenario único de disciplina y vigilancia para, al contrario, sugerirse la existencia de escenarios cambiantes, marcados por conflictos, negociaciones y distintas propuestas de prevención o de combate a la enfermedad. El texto abordará las diferentes concepciones médicas y 'profanas' de la lepra, así como las propuestas y prácticas de intervención social en Brasil y, en particular, en los estados de San Pablo y de Maranhão, desde los primeros tiempos de la República hasta las

  12. Os efeitos da hanseníase em homens e mulheres: um estudo de gênero The effects of Leprosy on men and women: a gender study

    Directory of Open Access Journals (Sweden)

    Maria Helena Pessini de Oliveira

    1998-01-01

    Full Text Available Por meio das representações sociais, detectamos diferentes experiências de viver a hanseníase no contexto familiar e individual de uma população constituída por 202 hansenianos (132 homens e 70 mulheres, inscritos no programa de controle e tratamento dos serviços de saúde de Ribeirão Preto. Duas etapas para coletas de informações foram realizadas. Na primeira, os hansenianos responderam a um questionário com perguntas estruturadas; na segunda, foram ouvidos relatos de situações vividas no cotidiano de dez homens e mulheres. Os dados revelaram que a doença mobilizou representações diferentes entre os homens e mulheres nos diferentes grupos sociais. A hanseníase representou um desequilíbrio entre os gêneros, acentuando as desigualdades já existentes no campo sócio-cultural e criando novos problemas responsáveis pelos prejuízos bio-psico-sociais e econômicos, além dos estigmas que pesam sobre os indivíduos. Tais resultados devem reorientar os programas de controle e tratamento, visando à recuperação social dos hansenianos, e também servir de paradigma a novas investigações.On the basis of social representations, we detected gender differences in family and individual living experiences for people with Hansen's disease (HD, or leprosy in a sample of 202 HD patients (132 men and 70 women enrolled in a public treatment and control program in Ribeirão Preto, São Paulo State. Information was gathered in two stages. First, the HD patients responded to a structured questionnaire, and second, the authors heard reports from 10 men and 10 women on their daily living situations. Data indicated that the disease receives different representations by men as compared to women in the different social groups. HD was found to be a source of gender imbalance, further aggravating existing sociocultural inequalities and creating new sources of biopsychosocial and economic harm, in addition to the stigmata weighing on individual

  13. 应用 Lauge-Hansen分型手术治疗踝关节骨折%Application of Lauge-Hansen classification for surgical treatment of ankle fractures

    Institute of Scientific and Technical Information of China (English)

    赵广超; 薛双桃; 桂召柳; 吴天亮; 林志祥; 曹松松; 夏太保

    2016-01-01

    目的:探讨应用Lauge-Hansen分型手术治疗踝关节骨折的临床疗效。方法对30例踝关节骨折患者按Lauge-Hansen分型行手术治疗。术中按分型的损伤机制进行复位,根据骨折特征选择合适内固定。对踝关节术后疗效使用Baird-Jackson评分标准评价。结果术后X线片显示骨折复位良好,踝穴形态恢复正常,内固定位置满意。患者均获得随访,时间3~46个月。按踝关节Baird-Jackson评分标准评价:优20例,良7例,可2例,差1例,优良率90%。结论应用Lauge-Hansen分型手术治疗踝关节骨折,可指导术中骨折复位,选择合适内固定,判断下胫腓联合损伤情况,提高手术疗效。%Objective To evaluate the clinical efficacy of surgical treatment of ankle fracture by Lauge -Hansen classi-fication.Methods Thirty cases of ankle fractures underwent surgical treatment according to Lauge -Hansen classifi-cation.Intraoperative reduction according to fractural mechanism of damage , the internal fixation was selected accord-ing to the fracture characteristic .The ankle postoperative curative effect was evaluated by Baird-Jackson criteria .Re-sults The postoperative X-ray film showed good fracture reduction , the ankle mortise shape was recoved to normal , internal fixation position satisfaction .All patients were followed up for 3~46 months.According to ankle Baird-Jack-son score criteria, the result was excellent in 20 cases, good in 7, fair in 2, and poor in 1, with the excellent-good rate of 90%.Conclusions Surgical treatment of ankle fracture by Lauge-Hansen classification can guide fracture re-duction of operation , select the appropriate internal fixation , judge the joint injury of the lower tibia and fibula , and improve surgery efficacy .

  14. Aplicação de modelo bayesiano empírico na análise espacial da ocorrência de hanseníase

    Directory of Open Access Journals (Sweden)

    Souza Wayner Vieira

    2001-01-01

    Full Text Available OBJETIVO: Analisar a distribuição espacial da hanseníase, identificar áreas de possível sub-registro de casos ou de provável alta transmissão (risco e verificar a associação dessa distribuição à existência de casos de formas multibacilares. MÉTODOS: O estudo foi realizado em Recife, PE, de acordo com 94 bairros analisados. A fonte de coleta de dados foi o Sistema de Informações sobre Agravos de Notificação do Ministério da Saúde. Foi adotada uma abordagem ecológica com utilização do método bayesiano empírico para suavização local de taxas, a partir de informações de bairros vizinhos por adjacência. RESULTADOS: A ocorrência média anual foi de 17,3% de casos novos em menores de 15 anos (28,3% de formas multibacilares, indicando um processo de intensa transmissão da doença. A análise da distribuição espacial de hanseníase apontou três áreas onde se concentram bairros com taxas de detecção elevadas e que possuem baixa condição de vida. CONCLUSÕES: O emprego do modelo bayesiano, baseado em informações de unidades espaciais vizinhas, permitiu estimar novamente indicadores epidemiológicos. Foi possível identificar áreas prioritárias para o programa de controle de hanseníase no município, tanto pelo elevado número de ocorrências correlacionado �� presença de formas multibacilares de doença em menores de 15 anos quanto pela existência de subnotificação.

  15. Estudo comparativo das médias móveis, dos índices baciloscópico e morfológico, em pacientes de hanseníase virchoviana tratados pela rifampicina e pela diamino-difenil-sulfona A comparative study of the variable averages of the bacilloscopic and morphologic indexes in virchowian hansen patients treated with rifampicin and with diamine-diphenyl-sulfone

    Directory of Open Access Journals (Sweden)

    Walter Belda

    1979-06-01

    Full Text Available São apresentados resultados clínicos e baciloscópicos obtidos, em estudo comparativo, na experimentação terapêutica da ação da rifampicina e diamino-difenil-sulfona na hanseníase virchoviana. Respectivamente 24 e 23 pacientes, relativamente homogeneizados, foram observados por um período mínimo de 12 meses e máximo de 24. É ressaltada a superioridade da ação da rifampicina, nos primeiros meses, em termos clínicos, e de redução do número de bacilos viáveis. É recomendado, pelo menos como etapa inicial do tratamento, o emprego da rifampicina na terapêutica da hanseníase virchoviana.The clinical and bacilloscopic results obtained in a comparative study of the therapeutic action of rifampicin and DDS in the treatment of the virchow form of Hansen's disease are presented. Two relatively homogeneous groups of 24 and 23 patients were observed during periods ranging from 12 to 24 months. The results demonstrated the superiority of the action of rifampicin during the first months of treatment, both in clinical aspects and in relation to the reduction of viable bacilli. Rifampicin is recommended for treatment of the virchow form of Hansen's disease, at least at the begining of the treatment.

  16. Hanseníase, preconceito e parrhesía: contribuições para se pensar saúde, educação e educação em saúde Hansen's disease, prejudice and parrhesia: reflective contributions on health, education and health education

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    Marcia Bastos de Sá

    2013-01-01

    Full Text Available Considerando que os campos profissionais da educação, da saúde e da educação em saúde implicam práticas destinadas ao governo das condutas dos indivíduos, desenvolvemos reflexão que visa contribuir para a problematização da formação profissional nesses campos. A partir de depoimento extraído de vídeo educativo que apresenta o tema do preconceito e do isolamento compulsório para portadores de hanseníase, tecemos considerações sobre a peculiaridade dos mecanismos de exclusão, conforme postulado por Michel Foucault, e apresentamos exemplos que evidenciam até que ponto esses mecanismos funcionaram, ainda recentemente, sobre os portadores da doença no Brasil. Retomando o fio dos eventos que levaram à mudança da denominação da doença - de lepra para hanseníase -, analisamos a luta empreendida por médico brasileiro contra o preconceito, alcançando uma reflexão de caráter ético, seguindo pistas das últimas investigações foucaultianas sobre o tema da constituição do sujeito moral e ativo, soberano de si mesmo.We consider that the professional fields of education, health and health education have practices that govern the conduct of individuals so we developed a reflection that aims to contribute towards problematizing professional training in these fields. Based on a testimony extracted from an educational video that presents the theme of prejudice and compulsory isolation for people with Hansen's disease, we discuss the peculiarity of the exclusion mechanisms, as postulated by Michel Foucault, and present examples that show to what extent these mechanisms have still functioned recently with those who have the disease in Brazil. Revisiting the events that led to the change of the disease's name - from leprosy to Hansen's disease - we analyzed the struggle of a Brazilian doctor against prejudice, making an ethical reflection following the clues of the Foucaultian investigations on the theme of the constitution of the

  17. Diagnóstico do dano físico e social após a alta medicamentosa das pessoas que tiveram hanseníase.

    OpenAIRE

    Nardi,Susilene Maria Tonelli

    2012-01-01

    Introdução: A hanseníase é uma doença crônica, infecto-contagiosa, insidiosa, tratável e crônica que provoca afecções dermatoneurológicas. As complicações decorrentes do comprometimento neurológico provocam seqüelas que freqüentemente atingem olhos, nariz, mãos e pés e se não tratados precocemente, evolui para deficiências físicas, por vezes irreversíveis e funcionalmente desastrosas para o indivíduo. No Brasil, o coeficiente de deficiências físicas graves e visíveis (Grau 2) no diagnóstico é...

  18. Caracterização dos macrófagos presentes nas lesões cutâneas da hanseníase: estudo por monoclonais

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    Euzenir Nunes Sarno

    1988-02-01

    Full Text Available As lesões cutâneas de 16 pacientes com hanseníase foram estudadas por imunofluorescência com anticorpos monoclonais anti-monócitos (OKM1 e anti-MO e anti-Ia (OKIa. Foi avaliada a atividade de fosfatase ácida utilizando-se naftol AS-B1 fosfato como substrato. Os macrófagos parecem constituir uma população heterogênea em relação aos antigenos estudados neste trabalho e quanto a atividade enzimática. Em todas as formas estudadas um grande número de células eram OKIa positivas.

  19. Meeting the privacy requirements for the development of a multi-centre patient registry in Canada: the Rick Hansen Spinal Cord Injury Registry.

    Science.gov (United States)

    Noonan, Vanessa K; Thorogood, Nancy P; Joshi, Phalgun B; Fehlings, Michael G; Craven, B Catharine; Linassi, Gary; Fourney, Daryl R; Kwon, Brian K; Bailey, Christopher S; Tsai, Eve C; Drew, Brian M; Ahn, Henry; Tsui, Deborah; Dvorak, Marcel F

    2013-05-01

    Privacy legislation addresses concerns regarding the privacy of personal information; however, its interpretation by research ethics boards has resulted in significant challenges to the collection, management, use and disclosure of personal health information for multi-centre research studies. This paper describes the strategy used to develop the national Rick Hansen Spinal Cord Injury Registry (RHSCIR) in accordance with privacy statutes and benchmarked against best practices. An analysis of the regional and national privacy legislation was conducted to determine the requirements for each of the 31 local RHSCIR sites and the national RHSCIR office. A national privacy and security framework was created for RHSCIR that includes a governance structure, standard operating procedures, training processes, physical and technical security and privacy impact assessments. The framework meets a high-water mark in ensuring privacy and security of personal health information nationally and may assist in the development of other national or international research initiatives.

  20. Meeting the Privacy Requirements for the Development of a Multi-Centre Patient Registry in Canada: The Rick Hansen Spinal Cord Injury Registry

    Science.gov (United States)

    Noonan, Vanessa K.; Thorogood, Nancy P.; Joshi, Phalgun B.; Fehlings, Michael G.; Craven, B. Catharine; Linassi, Gary; Fourney, Daryl R.; Kwon, Brian K.; Bailey, Christopher S.; Tsai, Eve C.; Drew, Brian M.; Ahn, Henry; Tsui, Deborah; Dvorak, Marcel F.

    2013-01-01

    Privacy legislation addresses concerns regarding the privacy of personal information; however, its interpretation by research ethics boards has resulted in significant challenges to the collection, management, use and disclosure of personal health information for multi-centre research studies. This paper describes the strategy used to develop the national Rick Hansen Spinal Cord Injury Registry (RHSCIR) in accordance with privacy statutes and benchmarked against best practices. An analysis of the regional and national privacy legislation was conducted to determine the requirements for each of the 31 local RHSCIR sites and the national RHSCIR office. A national privacy and security framework was created for RHSCIR that includes a governance structure, standard operating procedures, training processes, physical and technical security and privacy impact assessments. The framework meets a high-water mark in ensuring privacy and security of personal health information nationally and may assist in the development of other national or international research initiatives. PMID:23968640

  1. Electronic conductivity of Ce(0.9)Gd(0.1)O(1.95-δ) and Ce(0.8)Pr(0.2)O(2-δ): Hebb-Wagner polarisation in the case of redox active dopants and interference

    DEFF Research Database (Denmark)

    Chatzichristodoulou, Christodoulos; Hendriksen, Peter Vang

    2011-01-01

    The electronic conductivity of Ce(0.9)Gd(0.1)O(1.95-δ) and Ce(0.8)Pr(0.2)O(2-δ) under suppressed ionic flow was measured as a function of pO(2) in the range from 10(3) atm to 10(-17) atm for temperatures between 600 °C and 900 °C by means of Hebb-Wagner polarisation. The steady state I-V curve...... of Ce(0.9)Gd(0.1)O(1.95-δ) could be well described by the standard Hebb-Wagner equation [M. H. Hebb, J. Chem. Phys., 1952, 20, 185; C. Wagner, Z. Elektrochem., 1956, 60, 4], yielding expressions for the n- and p-type conductivity as a function of pO(2). On the other hand, significant deviation...... of the steady state I-V curve from the standard Hebb-Wagner equation was observed for the case of Ce(0.8)Pr(0.2)O(2-δ). It is shown that the I-V curve can be successfully reproduced when the presence of the redox active dopant, Pr(3+)/Pr(4+), is taken into account, whereas even better agreement can be reached...

  2. Situação da endemia da hanseníase no município de São Paulo, Brasil (1976-1977 The situation of endemic Hansen's disease in the county of S. Paulo, Brazil (1976-1977

    Directory of Open Access Journals (Sweden)

    Clovis Lombardi

    1979-12-01

    Full Text Available Descreve-se e avalia-se a situação da endemia da hanseníase no município de São Paulo no biênio 1976/1977, caracterizando-a como problema de saúde pública, através da apresentação e discussão dos coeficientes de prevalência e de incidência, por local de residência nos diversos distritos e subdistritos e nas zonas Central, Intermediária e Periférica do município. Os recursos sanitários existentes são descritos e avaliados segundo os mesmos critérios de localização, tentando-se relacionar sua distribuição com a dos índices endêmicos verificados.The situation of endemic Hansen's disease in the county of S. Paulo, Brazil during 1976 and 1977 is described and analyzed and also characterized as a public health problem through the presentation and discussion of prevalence and incidence rates according to the location of the homes in the different districts and subdistricts of the city including the central, intermediary, and outlying zones of the citycounty. The specific medical resources available are described and evaluated according to the same criteria. An attempt was made to relate the distribution of the resources to the distribution of the endemic rates found.

  3. Representações sociais e hanseníase em São Domingos do Capim: um estudo de caso na Amazônia Social representations and hansen's disease in São Domingos do Capim, state of Pará: a study in brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Anete Umbelina Ferreira de Almeida Lins

    2010-01-01

    Full Text Available Este estudo analisa as representações sociais da hanseníase em São Domingos do Capim-PA, a partir da perspectiva da antropologia da doença. As representações são compreendidas como estruturas dinâmicas socialmente construídas que fundamentam as ações dos sujeitos e dos grupos na resolução dos episódios de doença e na produção de sentido para as experiências de adoecimento. Para compreender a lógica das interpretações da doença, foram reconstituídos os itinerários terapêuticos dos doentes, a partir de dados coletados na observação de campo, realizada ao longo de quatro anos, e entrevistas narrativas com doentes, familiares e agentes comunitários de saúde. Foram deduzidas quatro categorias nosológicas êmicas referentes aos sintomas da hanseníase - "manchas", "lepra", "feitiço" e "hanseníase" -, que constituem o repertório a partir do qual as interpretações e práticas são formuladas. O uso das diferentes categorias ocorre segundo esquemas locais que permitem a avaliação dos contextos pessoal e social de irrupção da doença numa dinâmica que articula as percepções do doente e de seus familiares, as interpretações e diagnósticos de curadores tradicionais e a abordagem dos profissionais da Biomedicina. O estudo mostra que o repertório interpretativo e os meios terapêuticos da Biomedicina são reinterpretados, pelos doentes, segundo a lógica das representações e das práticas locais de saúde, e que o controle da endemia hansênica pressupõe a compreensão das dinâmicas sociais implicadas nas interpretações e práticas da doença, de forma a possibilitar o estabelecimento de uma relação dialógica entre os profissionais de saúde e os atores locais.This study analyzes the social representations of Hansen's disease in São Domingos do Capim-PA, from the perspective of the anthropology of disease. The representations are understood as socially constructed dynamic structures that underlie the

  4. Avaliação dos parâmetros de solubilidade de Hildebrand/Hansen na seleção de solventes para a extração de pesticidas organoclorados do solo

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    Ricardo D Villa

    2011-09-01

    Full Text Available This work evaluated the use of the Hildebrand/Hansen solubility parameters for selection of solvents for extraction of the organochlorine pesticides pp' DDT, pp' DDE, Aldrin and a-Endossulfan from soil using columns packed with Al2O3. The mixtures hexane:dichloromethane (7:3; v/v, hexane:acetonitrile (1:1; v/v, hexane:acetone (1:1; v/v and pure hexane were chosen as extracting solutions. In the addition and recovery tests, different extraction solutions provided high recoveries percentages (>75% with coefficients of variation below 15%. The recoveries are in agreement with the Hildebrand/Hansen parameters, demonstrating its applicability in the selection of extracting solution and in the replacement of toxic solvents, as dichloromethane

  5. Dapsone hypersensitivity syndrome in an adolescent during treatment during of leprosy Síndrome de hipersensibilidade à dapsona em uma adolescente durante tratamento de hanseníase

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    Fábio Bucaretchi

    2004-04-01

    Full Text Available A 12 y old girl was admitted 24 days after start a WHO multidrug therapy scheme for multibacillary leprosy (dapsone, clofazimine and rifampicin with intense jaundice, generalized lymphadenopathy, hepatoesplenomegaly, oral erosions, conjunctivitis, morbiliform rash and edema of face, ankles and hands. The main laboratory data on admission included: hemoglobin, 8.4 g/dL; WBC, 15,710 cells/mm³; platelet count, 100,000 cells/mm³; INR = 1.49; increased serum levels of aspartate and alanine aminotransferases, gamma-glutamyl transpeptidase, alkaline phosphatase, direct and indirect bilirubin. Following, the clinical conditions had deteriorated, developing exfoliative dermatitis, shock, generalized edema, acute renal and hepatic failure, pancytopenia, intestinal bleeding, pneumonia, urinary tract infection and bacteremia, needing adrenergic drugs, replacement of fluids and blood product components, and antibiotics. Ten days after admission she started to improve, and was discharged to home at day 39th, after start new supervised treatment for leprosy with clofazimine and rifampicin, without adverse effects. This presentation fulfils the criteria for the diagnosis of dapsone hypersensitivity syndrome (fever, generalized lymphadenopathy, exfoliative rash, anemia and liver involvement with mixed hepatocellular and cholestatic features. Physicians, mainly in geographical areas with high prevalence rates of leprosy, should be aware to this severe, and probably not so rare, hypersensitivity reaction to dapsone.Menina, 12 anos, foi admitida referindo o uso de esquema de poliquimioterapia preconizado pela OMS para tratamento de hanseníase forma multicibacilar (dapsona, rifampicina e clofazimina há 24 dias, apresentando icterícia, linfadenomegalia generalizada, hepatoesplenomegalia, conjuntivite, úlceras orais, exantema morbiliforme e edema de face, mãos e tornozelo. Os principais achados laboratoriais à admissão incluíam: hemoglobina, 8,4 g

  6. Conhecimento e experiências do cirurgião-dentista sobre hanseníase em Cáceres, MT, Brasil = Dentists’ knowledge and experiences related to leprosy in Cáceres, MT, Brazil

    Directory of Open Access Journals (Sweden)

    Cortela, Denise da Costa Boamorte

    2008-01-01

    Full Text Available Objetivo: Analisar o conhecimento e a experiência dos cirurgiões-dentistas (CDs do município de Cáceres-MT relativos a suspeita diagnóstica e encaminhamento de casos de hanseníase. Metodologia: Estudo transversal de inquérito com 60 CDs. Utilizou-se um questionário auto-aplicado com variáveis relacionadas à formação do profissional, ao conhecimento e à experiência em relação à hanseníase. Os dados foram analisados por regressão logística com intervalo de confiança (IC de 95%. Resultados: A maioria dos CDs sentiu pouca segurança em relação a seus conhecimentos sobre hanseníase, 43% realizaram suspeita de casos e/ou encaminhamento. A probabilidade de um profissional com tempo de exercício maior que 5 anos realizar suspeita de casos e/ou encaminhamento foi 4 vezes àquela observada entre os CDs com menor tempo de residência na cidade (ORajust = 4,39; IC 95%: 1,26-15,23. Tal probabilidade para profissionais especialistas foi 7 vezes à observada entre nãoespecialistas (ORajust = 7,73; IC 95%: 1,51-39,64. Conclusão: Quase metade dos CDs realizou encaminhamento de casos suspeito de hanseníase, principalmente aqueles com mais de cinco anos de exercício profissional na cidade ou que possuíam alguma especialidade. No entanto, esses vêm contribuindo timidamente e com práticas isoladas, pois apresentaram limitações de conhecimentos específicos relativos à doença

  7. Prophylaxis and exclusion: compulsory isolation of Hansen's disease patients in São Paulo Profilaxia e exclusão: o isolamento compulsório dos hansenianos em São Paulo

    Directory of Open Access Journals (Sweden)

    Yara Nogueira Monteiro

    2003-01-01

    Full Text Available This article aims to retrieve the history of Hansen's disease in Brazil, analyzing the medical thinking of the time and the shaping of health policies that permitted the implementation, in São Paulo, of a prophylactic policy of compulsory exclusion for all Hansen's disease patients. It also analyzes how the structuring and implementation of this policy led to a 'São Paulo model' that strongly influenced the rest of the country. It addresses the creation of the state's network of leper colonies, their characteristics and the emergence of a veritable 'parallel state' that endured until 1967, with complete disregard of all the changes taking place in both national and international prophylactic policymaking.Este artigo busca resgatar a história da hanseníase no Brasil, analisando o pensamento médico e o direcionamento das políticas de saúde que possibilitaram a implantação, em São Paulo, de uma política profilática centrada na exclusão compulsória de todos os portadores de hanseníase. Analisa ainda como a estruturação e implantação dessa política resultou no 'modelo paulista', que exerceu forte influência no país. Estuda a formação da rede asilar, as suas características e o surgimento de um verdadeiro 'Estado paralelo', que subsistiu até 1967, à revelia das descobertas terapêuticas e das modificações havidas no direcionamento das formas de tratamento e prevenção nacional e internacional.

  8. Sorologia da hanseníase utilizando PGL-I: revisão sistemática Leprosy serology using PGL-I: a systematic review

    Directory of Open Access Journals (Sweden)

    Rodrigo Scaliante de Moura

    2008-01-01

    Full Text Available A sorologia utilizando o antígeno espécie-específico do Mycobacterium leprae, PGL-I, pode ser um marcador de carga bacteriana em pacientes com hanseníase. Estudos identificaram potencial de uso da sorologia na classificação de pacientes para fins de tratamento, monitoramento de terapia, risco de recidiva e na seleção dos contatos com maior risco de adoecer. Foi realizada uma revisão sistemática e 26 artigos foram incluídos na análise comparativa. Avaliamos os resultados do uso da sorologia PGL-I em diferentes situações, suas limitações e possíveis aplicações. Estudos mostraram eficácia da sorologia PGL-I na classificação de pacientes, monitoramento da terapia, e nas reações hansênicas como teste preditivo. Para diagnóstico precoce e seguimento de população de alto risco, as metodologias utilizadas ainda não demonstraram custo-benefício favorável, porém estudos indicam que a utilização do teste poderá influenciar positivamente nos programas de controle da hanseníase. Com técnicas simples e robustas, o uso da sorologia PGL-I é viável.Serology using a species-specific antigen for Mycobacterium leprae, PGL-I, could be a marker for the bacterial load of patients with leprosy. Various studies have identified the potential use of serology in the classification of patients for treatment purposes, case monitoring, identification of the risk of relapse and selection of household contacts with a higher risk of contracting the disease. A systematic review of the literature was conducted and 26 articles were included in this comparative analysis. The results of the use of PGL-I serology in different situations, its limitations and possible applications were evaluated. Studies show the efficacy of PGL-I serology in the classification of patients, treatment monitoring and as a predictive test for leprosy reactions. To improve early diagnosis and follow-up of the population at greatest risk of developing leprosy, the

  9. Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study.

    Science.gov (United States)

    Mukhopadhyay, Somnath; Sen, Swarnali; Datta, Himadri

    2015-01-01

    To compare the role of topically applied serum therapy with preservative-free artificial tear (AT) drops in patients with moderate to severe dry eye in Hansen's disease along with change in tear protein profile. 144 consecutive patients were randomly divided into three groups. After a baseline examination of clinical parameters, each of the patients received designated modality of topical therapy six times a day for 6 weeks. Post-treatment documentation of clinical parameters was done at 6 weeks, and then at 12 weeks after discontinuation of topical therapy. Analysis of three tear proteins using gel electrophoresis (sodium dodecyl sulfate polyacrylamide gel electrophoresis) was done at baseline, at the first and second post-treatment visits. In the cord blood serum (CBS) group, except for McMonnies score and staining score, all other clinical parameters showed continued improvement in the first and second post-treatment analyses. In the autologous serum (ALS) group, all the clinical parameters except Schirmer's I showed significant improvement in the first post-treatment analysis .This was sustained at a significant level in the second analysis except for tear film break-up time (TBUT) and conjunctival impression cytology grading. In the AT group, all the parameters improved at a non-significant level except for TBUT in the first analysis. In the next analysis, apart from McMonnies score and TBUT, other clinical parameters did not improve. In the ALS and CBS groups, tear lysozyme, lactoferrin levels improved in both post-treatment measurements (statistically insignificant).Total tear protein continued to increase at statistically significant levels in the first and second post-treatment analyses in the CBS group and at a statistically insignificant level in the ALS group. In the AT group, the three tear proteins continued to decrease in both the analyses. In moderate to severe dry eye in Hansen's disease, serum therapy in comparison with AT drops, improves

  10. Early postoperative active mobilisation versus immobilisation following tibialis posterior tendon transfer for foot-drop correction in patients with Hansen's disease.

    Science.gov (United States)

    Rath, Santosh; Schreuders, Ton A R; Selles, Ruud W

    2010-03-01

    After tibialis posterior tendon transfer surgery for foot-drop correction, the foot is traditionally immobilised for several weeks. To test the feasibility of early mobilisation after this procedure in patients with Hansen's disease, 21 consecutive patients received active mobilisation of the transfer starting on the 5th postoperative day. Transfer insertion strength was enhanced by Pulvertaft weave. The results were compared with a historical cohort of 21 patients receiving 4 weeks of immobilisation. The primary outcomes were active dorsiflexion, active plantar flexion and total active motion at the ankle, tendon-insertion pullout and time until discharge from rehabilitation with independent walking without aid. Assessments at discharge from rehabilitation and the last clinical follow-up at more than 1 year were compared between both groups. The Student's t-test was used to compare data between the groups, and 95% confidence interval of the difference between groups was determined. A p-value of 0.05 was considered statistically significant. The average follow-up was 22 months for both groups. There was no incidence of insertion pullout of the tendon transfer in either group. In addition, there was no difference in active dorsiflexion angle between the groups at discharge (mean difference: 2.2 degrees, p=0.22) and final assessment (mean difference: 2.3 degrees, p=0.42). The plantar flexion angles were similar in both groups at discharge (mean difference: 0.5 degrees, p=0.86) and final assessment (mean difference: 0.5 degrees, p=0.57). In addition, there was no difference in total active motion between the groups at discharge (mean difference: 2 degrees, p=0.54) and final assessment (mean difference: 1 degrees, p=0.49). The patients were discharged from rehabilitation with independent walking at 44.04+/-7.9 days after surgery in the mobilisation group compared to 57.07+/-2.3 days in the immobilisation group. This indicates a significant difference in morbidity (mean

  11. Baciloscopia da conjuntiva no diagnóstico e acompanhamento de pacientes portadores de hanseníase Conjunctival bacilloscopy in leprosy diagnosis and follow-up

    Directory of Open Access Journals (Sweden)

    Adriana Souza Moreira

    2006-12-01

    Full Text Available OBJETIVO: Estudar a presença do Mycobacterium leprae na conjuntiva ocular e validar a baciloscopia de conjuntiva como teste diagnóstico e de acompanhamento da hanseníase. MÉTODOS: Foi realizado raspado de conjuntiva tarsal superior em 52 pacientes portadores de hanseníase recém-diagnosticados (26 multibacilares e 26 paucibacilares no período de julho a setembro de 2004 na clínica Oculistas Associados de Brasília e foram analisados os resultados da baciloscopia de conjuntiva a fim de compará-la com a baciloscopia da linfa (padrão-ouro. RESULTADOS: A avaliação da correlação entre o índice baciloscópico da conjuntiva (IBC e índice baciloscópico da linfa (IBL medida pelo coeficiente de correlação linear de Pearson é 76,3% (pPURPOSE: To identify Mycobacterium leprae in ocular conjunctivae and evaluate conjunctival bacilloscopy as leprosy diagnosis and follow-up test. METHODS: We used the superior tarsal conjunctiva scraping technique in 52 newly diagnosed leprosy patients between July and September 2004 at the "Oculistas Associados de Brasília", in Brasília, DF, Brazil, and compared the conjunctival bacilloscopy with skin bacilloscopy. RESULTS: Both the conjunctival bacilloscopy index (CBI and skin bacilloscopy index (SBI showed correlation since Pearson's r and Cohen kappa measure of agreement were respectively 76.3% (p<0.01 and 0.615 (p<0.01. Pearson chi-square also evidenced the correlation (p<0.01. Comparison of CBI and SBI (17 cases of positive CBI out of 26 SBI gives a sensitivity of 65.4% (CI95% - 0.519-0.690; 25 cases of positive CBI out of 26 cases of negative SBI give a specificity of 96.2% (CI95% - 0.826-0.998; positive predictive value of 94.4%; negative predictive value of 73.5%, and accuracy of 80.8%. Likelihood ratio was 17. Mean time to eliminate the bacilli from conjunctiva was 5 months (CI95% - 3.57-6.43. CONCLUSION: We suggest the use of conjunctival bacilloscopy in addition with skin bacilloscopy to confirm

  12. Hanseníase em menores de 15 anos no Vale do Jequitinhonha, Minas Gerais, Brasil Lepra en menores de 15 años en el Vale del Jequitinhonha, Minas Gerais, Bra Hansen's Disease in children under fifteen years-old in Jequitinhonha Valley, Minas Gerais, Brazil

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    Francisco Carlos Félix Lana

    2007-12-01

    Full Text Available A hanseníase é uma doença de evolução lenta que acomete principalmente a população adulta. A detecção de casos em crianças indica a manutenção da endemia e a precocidade da exposição da população ao bacilo. Este é um estudo ecológico cujo objetivo é analisar a ocorrência da hanseníase em menores de 15 anos no Vale do Jequitinhonha através de indicadores epidemiológicos e operacionais. Os resultados apontam para a manutenção da endemia na região, evidenciando uma passividade dos serviços de saúde e a necessidade de implementação de medidas de prevenção e controle específicas para essa faixa etária, a fim de diminuir a transmissão da doença e os eventuais prejuízos que ela pode acarretar à vida do indivíduo, principalmente, ao acometê-lo na infância.La Lepra es una enfermedad de evolución lenta que acomete principalmente a la población adulta. La detección de casos en niños indica el mantenimiento de la endemia y la precocidad de la exposición de la población al bacilo. Éste es un estudio ecológico cuyo objetivo es analizar la ocurrencia de lepra en menores de 15 años en el Valle del Jequitinhonha a través de indicadores epidemiológicos y operacionales. Los resultados apuntan para el mantenimiento de la endemia en la región, evidenciando una pasividad de los servicios de salud y la necesidad de implementación de medidas de prevención y control específicas para esafaja etaria , a fin de disminuir la transmisión de la enfermedad y los eventuales perjuicios que ella puede acarrearle a la vida del individuo, principalmente, al acometerlo en la infancia.Hansen's disease has a slow evolution, which mostly affects the adult population. Detecting cases in children shows that the endemic continues and there is early exposure of the population to the bacillus. This is an ecological study with the objective of analyzing the occurrence of Hansen's disease in children under fifteen in the Jequitinhonha

  13. Culturas de bacilos ácido-álcool resistentes isolados de hematófagos infectados em leprosos: evidências de se tratar do bacilo de Hansen Isolation and cultures of acid-fast bacilli from Hematophagi infected in lepers: evidences that the Hansen bacillus is in cause

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    H. C. de Souza-Araújo

    1944-02-01

    Full Text Available The A. summarises the history of his first culture of acidfast bacillus isolated directly from leprosy lesions (Sample José and refers about two samples recovered from guinea pig and white rat inoculated with said culture. Then the A. completes his previous descriptions of four cultures of acidfast bacilli isolated by him from ticks (Amblyomma cajaennense and Boophilus microplus, two cultures from each species infected experimentally in lepers. The A. having found specimens of two species of Triatomidae (Triatoma infestans and Panstrongylus megistus naturally infected with HANSEN bacillus in huts habited by lepers in the State of Minas Gerais (Dec. 1942, started a series of experiments, using larvae and nymphs of T. infestans bred in laboratory at the Instituto Oswaldo Cruz, to infect in active cases of leprosy, in the city of Rio de Janeiro, could obtain two new samples of cultures of acid-fast bacilli (Ns. 6 and 7 of his set. In this papaer the A. studies the biological properties of said cultures, proving that Penicilin has not effect upon them, like other substances. The sulphuric and acetic acids were used to purify some of the cultures, with good results, the cultures becoming more rich and growing faster. Potassium hydroxide Sodium (10% solution was also used with success to isolate and to purify the cultures, but it seems that it affects the bacilli in some way. In flud glycerinated media the majority of such cultures produce velum suitable for the preparation of antigens for skin tests and for therapeutical use. At last the A. says that he is becoming convinced that the HANSEN bacillus is in cause, especially after thee evidences of culturing the bacillus from one patient, in different opportunities.

  14. Táticas cotidianas e ação coletiva: a resistência das pessoas atingidas pela hanseníase Everyday tactics and collective action: how the people affected with Hansen's disease (leprosy politically resisted to the disease

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    Ricardo Fabrino Mendonça

    2012-06-01

    Full Text Available Apesar da existência de uma considerável literatura sobre a história da hanseníase, predominam os estudos que enfocam a opressão e a dominação a que os antigos pacientes foram submetidos. Permanecem pouco estudadas as formas de resistência e as lutas políticas geradas por esses sujeitos. O presente artigo é um esforço nessa direção, abordando como a própria vida cotidiana e as lutas organizadas permitiram o questionamento de sentidos e práticas opressoras. O estudo está embasado em um processo de observação em antigos hospitais-colônia brasileiros, 12 grupos de conversação com moradores dessas instituições, entrevistas não-estruturadas com lideranças do Movimento de Reintegração das Pessoas Atingidas pela Hanseníase (Morhan e 45 edições do Jornal do Morhan.Despite the existence of a considerable literature about the history of leprosy, most studies focus on the oppression and domination to which former patients were subjected. The resistance and political struggles produced by these individuals remain underexplored. This paper is an attempt to introduce this issue, by discussing how everyday life and organized collective struggles have allowed the systematic challenge of oppressive meanings and social practices. The study is based on a observation process in former leprosy colonies, 12 conversation groups with colony dwellers, non-structured interviews with highly ranked activists from Morhan (Movement for the Reintegration of People Affected by Leprosy, and 45 editions of Morhan's newsletter.

  15. Supercritical Fluid Extraction of Direct Coal Liquefaction Residue Basing on Hansen Solubility Parameters%基于Hansen溶度参数的煤直接液化残渣超临界萃取

    Institute of Scientific and Technical Information of China (English)

    姜广策; 林雄超; 张生娟; 王中奇; 王永刚; 陈强; 朱豫飞

    2015-01-01

    以丙酮、异丙醇和苯为溶剂在超临界状态下对煤直接液化残渣进行萃取,应用溶度参数分析了超临界萃取环境中溶剂和萃取原料的变化;基于Hansen拓展方法建立了关联Hansen溶度参数和萃取收率的理论方程。结果表明,临界温度较高。以色散力溶度参数为主的苯的萃取收率明显高于其它2种溶剂;液化残渣中可萃出组分的理想溶解度随温度的升高而增大,该效应也是超临界溶剂萃取重质组分时萃取收率提高的重要原因;萃取收率与Hansen溶度参数之间的回归模型与实验结果具有较好的一致性,证明Hansen溶度参数理论和Hansen拓展方法适用于描述煤直接液化残渣的超临界萃取过程。%The supercritical fluid extraction( SFE) of direct coal liquefaction residue using acetone, isopro-panol and benzene as solvents was investigated. The Hansen solubility parameters were used to clarify the variations of both solvent and the solute in SFE process. An empirical equation in terms of the extended Hansen approach was proposed to correlate the extraction capacity with the Hansen solubility parameters of solvents. The results show that the extraction yield using supercritical benzene, of which the dispersive compo-nent is the major in total solubility parameters, obtained the highest extraction yield. The ideal solubility on organic components in direct coal liquefaction residue improved with the extraction temperature increasing. The empirical equation shows high consistency with experimental results. As a consequence, the theory of Hansen solubility parameter and extended Hansen approach are applicable to the study on supercritical fluid extraction of direct coal liquefaction residue.

  16. Fundamentos epidemiológicos y perfil de la situación de discapacidad de la población con enfermedad Hansen del Valle del Cauca.

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    María Nora Hurtado

    2009-11-01

    Full Text Available El presente estudio identificó el perfil sociodemográfico y necesidades de la población de personas con condición de salud derivada de la enfermedad de Hansen. Para definir el perfil de discapacidad se usaron los conceptos desarrollados por la Organización Mundial de la Salud en la Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud. Los resultados definen los parámetros de la población: a nivel de las deficiencias, se encuentran alteraciones funcionales y estructurales del sistema nervioso periférico, piel y del movimiento. La limitación en la actividad se presenta para la ejecución de tareas y demandas generales, movilidad, autocuidado y vida doméstica. La restricción de la participación varía dependiendo de la zona, urbana o rural. Las recomendaciones apuntan al establecimiento de programas de rehabilitación integral, donde se articule la promoción de la salud, la prevención de la discapacidad, la rehabilitación funcional, profesional y social.

  17. Programa de Controle da Hanseníase: uma avaliação da implantação no nível distrital

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    Danielle Rodrigues Leal

    Full Text Available RESUMO Constitui objetivo deste estudo o de avaliar a implantação das ações do Programa de Controle da Hanseníase (PCH em nível distrital no município de Recife, Pernambuco. Trata-se de avaliação normativa, baseada em critérios e parâmetros orientados pela construção de um modelo lógico. O grau de implantação do PCH no distrito foi classificado como parcialmente adequado. Os critérios pior avaliados quanto à estrutura foram os recursos humanos e o espaço físico e quanto ao processo, o acolhimento, a educação permanente e a cogestão. A avaliação evidenciou que avanços ainda são necessários na descentralização das ações do PCH para o nível local.

  18. Hanseníase virchowiana em cardiopata chagásico: relato de necropsia Generalized hanseniasis in Chagas' myocardiopathy: necropsy study

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    Marcus Aurelho de Lima

    1998-08-01

    Full Text Available Relata-se caso de hanseníase virchowiana diagnosticada à necropsia, com alterações cardíacas causadas diretamente por micobactérias, em homem de 34 anos portador de miocardiopatia crônica chagásica. Enfatiza-se o possível papel de mediadores inflamatórios na gênese da disfunção miocárdica; bem como a possibilidade de que fatores associados à insuficiência cardíaca, como esplenomegalia congestiva e infartos esplênicos, possam causar imunodepressão, predispondo à infecção generalizada.This is a case report of lepromatous infection diagnosed at necropsy, with cardiac alterations directly caused by mycobacteria, in a 34-year old black male with the cardiac form of Chagas' disease. The possible role of inflammatory mediators on cardiac dysfunction, and the possibility that immunedepression may be due to factors associated with heart failure, as congestive splenomegaly and splenic infarctions, are emphasized.

  19. Perfil dos pacientes acometidos pela hanseníase atendidos no Ambulatório de Dermatologia do Hospital Evangélico de Curitiba Profile of patients affected by Hansen's disease seen at the Outpatient Clinic of Dermatology at Hospital Evangélico de Curitiba

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    Anelise Roskamp Budel

    2011-10-01

    Full Text Available FUNDAMENTOS: A hanseníase é uma enfermidade infecto-contagiosa, com distribuição mundial. Apesar de curável, permanece como um problema de saúde pública, sendo o Brasil o segundo país mais endêmico do mundo. As lesões cutâneas e o acometimento neural, que levam às principais incapacidades físicas, pioram a autoestima dos doentes, levam a uma queda da qualidade de vida e interferem na vida dos mesmos. OBJETIVO: Traçar um perfil dos pacientes acometidos pela hanseníase, atendidos no Ambulatório de Dermatologia do Hospital Evangélico de Curitiba, e caracterizar os níveis de qualidade de vida da amostra na semana prévia à pesquisa, por meio do questionário Dermatology Life Quality Index. MÉTODO: Aplicação do Dermatology Life Quality Index em 22 pacientes diagnosticados com hanseníase no período de maio a outubro de 2009. RESULTADOS: Em meio aos 22 pacientes que participaram do estudo, encontraram-se 55% do sexo masculino e 45% do sexo feminino, com idade média de 50,2 anos. Os escores obtidos na aplicação do Dermatology Life Quality Index variaram de 1 a 25 pontos, sendo a média 10,23. A maioria dos pacientes (50% apresentou escore na dimensão do grave ou muito grave; 31,8% dos pacientes, do leve ao moderado, e 18,2% dos pacientes informaram que não houve comprometimento da qualidade de vida. CONCLUSÃO: O perfil de pacientes acometidos pela hanseníase encontrado neste estudo foram homens, com idade média de 50 anos e com forma multibacilar. A aplicação do Dermatology Life Quality Index permitiu verificar que o escore de comprometimento de qualidade de vida grave ou muito grave foi predominante na amostra, tendo mais impacto nas mulheres e não apresentando diferença em relação à hanseníase pauci ou multibacilar.BACKGROUND: Leprosy or Hansen's disease is a chronic infectious disease with worldwide distribution. Although it is a curable disease, it remains as a public health problem, with Brazil being the

  20. Epidemiologia da hanseníase em coorte de contatos intradomiciliares no Rio de Janeiro (1987-1991 Leprosy epidemiology in a cohort of household contacts in Rio de Janeiro (1987-1991

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    Haroldo José de Matos

    1999-09-01

    Full Text Available Este trabalho foi desenvolvido para estudar os fatores que influem no adoecimento dos contatos intradomiciliares de hanseníase. Foi estabelecida uma coorte de contatos intradomiciliares de hanseníase no setor de Hanseníase da Fiocruz, no Rio de Janeiro. Entre 1987 e 1991, em que foram acompanhados 670 contatos saudáveis, a taxa de incidência por pessoa-ano de follow-up foi de 0,01694. Porém, houve variação com o tempo de acompanhamento de cada indivíduo, sendo de 0,06385 ao final do primeiro ano, de 0,03299 ao final do segundo, 0,02370 ao final do terceiro, 0,018622 ao final do quarto e 0,01694 ao final do período. Foi especificado um modelo de regressão logística para os indivíduos acompanhados nos primeiros cinco anos, envolvendo 758 contatos, incluindo nessa situação os casos co-prevalentes. O risco de incidência de hanseníase está relacionado com a negatividade do teste de Mitsuda, com OR de 3,093 (IC95% = 1,735-5,514, com a vacinação pelo BCG, OR de 0,3802 (IC95% = 0,2151-0,66719, e com a forma multibacilar do caso-índice, OR de 2,547 (IC95% = 1,249-5,192. Os resultados indicam que a incidência da hanseníase em contatos está associada à forma multibacilar da doença e aos fatores imunes dos contatos.This study aimed to identify factors influencing the development of leprosy (Hansen's disease in household contacts. A dynamic cohort was analyzed from 1987 to 1991 at the Hansen's Disease Department of the Oswaldo Cruz Foundation in Rio de Janeiro. The incidence rate was 0.01694 person-years of follow-up. Nevertheless, for subjects at the end of the first year of follow-up the incidence rate was 0.06385 (end of second year, 0.03299; end of third year, 0.02370; end of fourth year, 0.018622; and end of observation period, 0.01694. A stepwise multivariate logistic regression model was proposed to study the risk of developing leprosy, including co-prevalent cases, totaling 758 contacts. In the final model, the risk was

  1. Deficiências após a alta medicamentosa da hanseníase: prevalência e distribuição espacial

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    Susilene Maria Tonelli Nardi

    2012-12-01

    Full Text Available OBJETIVO: Estimar a frequência das deficiências físicas em pacientes tratados de hanseníase após alta medicamentosa e analisar sua distribuição espacial. MÉTODOS: Estudo descritivo transversal com 232 pessoas tratadas de hanseníase de 1998 a 2006. As deficiências físicas foram avaliadas pelo Grau de Incapacidades da Organização Mundial da Saúde (GI/OMS e pelo Eye-Hand-Foot (EHF. Os ex-pacientes foram geocodificados pelo endereço de residência e os serviços de reabilitação pelo endereço de sua sede. Foram apresentadas as frequências para o total e para os grupos grau 0, grau 1 e grau 2 do GI-OMS, considerando-se as variáveis clínicas e sociodemográficas na análise descritiva. Foram utilizados os testes t de Student, qui-quadrado (χ2 ou de Fisher, conforme apropriado, considerando-se significativos p < 0,05. RESULTADOS: Cerca de 51,6% era do sexo feminino, com média de idade de 54 anos (dp15,7; 30,5% tinha menos de dois anos de educação formal; 43,5% trabalhava e 26,9% estava aposentado; a forma dimorfa predominou (39,9%. As deficiências avaliadas pelo GI-OMS e pelo EHF atingiram 32% dos ex-pacientes. A presença de deficiências foi maior com o aumento da idade (p = 0,029, em casos multibacilares (p = 0,005 e com julgamento ruim do paciente sobre sua saúde física (p < 0,001. Os que necessitavam de prevenção/reabilitação percorreram distância média de 5,5 km até o serviço de reabilitação. As pessoas com deficiência física estavam distribuídas em todo o município, mas concentravam-se na área mais populosa e de maior carência socioeconômica. CONCLUSÕES: A frequência de deficiências é elevada após a alta medicamentosa. Os ex-pacientes mais velhos, os que tiveram formas multibacilares da doença, os de baixa escolaridade e os que julgam mal a própria saúde física merecem atenção especial para a prevenção e reabilitação de deficiências. A distância entre os serviços de reabilitação e

  2. Profile of patients affected by Hansen's disease seen at the Outpatient Clinic of Dermatology at Hospital Evangélico de Curitiba.

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    Budel, Anelise Roskamp; Raymundo, Anelise Rocha; Costa, Carla Fabiane da; Gerhardt, Cristina; Pedri, Lucas Eduardo

    2011-01-01

    Leprosy or Hansen's disease is a chronic infectious disease with worldwide distribution. Although it is a curable disease, it remains as a public health problem, with Brazil being the second most endemic country in the world. The skin lesions and neural damage, which lead to physical disabilities, affect the patients' self-esteem, cause a decrease in quality of life and interfere in the patients' lives. Identify the profile of the patients affected by leprosy seen at the Outpatient Clinic of Dermatology of Hospital Evangélico de Curitiba and characterize the levels of quality of life of the sample in the week prior to the survey by means of the Dermatology Life Quality Index questionnaire. Application of the Dermatology Life Quality Index to 22 patients diagnosed with leprosy in the period from May to October 2009. Among the 22 patients who participated in the study, 55% were male and 45% were female, with a mean age of 50.2 years. The scores obtained with the Dermatology Life Quality Index ranged from 1 to 25 points, with a mean of 10.23. Most of the patients (50%) had scores in the range severe or very severe; 31.8% of the patients obtained scores in the range mild or moderate, and 18.2% of the patients reported that there was no impairment of their quality of life. The profile of the patients affected by leprosy in this study were men, with a mean age of 50 years and presenting the multibacillary form of the disease. The application of the Dermatology Life Quality Index questionnaire allowed us to verify that the score severe or very severe for quality of life was predominant in the sample, with higher impact on women and no significant difference concerning pauci or multibacillary leprosy.

  3. O doente de hanseníase em Campinas: uma perspectiva antropológica People with leprosy in Campinas, Brazil: an anthropological perspective

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    Marcos S. Queiroz

    1995-09-01

    Full Text Available Este artigo estuda a experiência de vida de doentes e comunicantes de hanseníase em Campinas, Brasil, a partir da análise de suas representações sobre saúde, doença e terapêutica. Trata-se de captar no interior das condições de vida e de trabalho destes indivíduos as estratégias que permitam adaptação ao meio social e familiar, subsistência e convivência com a doença. Atenção especial é dada à maneira pela qual estes indivíduos enfrentam o problema de manutenção e recuperação da saúde, assim como avaliam os serviços e as práticas oficiais e não-oficiais de saúde.This article studies the life experiences of people with leprosy and their intra-domiciliary families in Campinas, Brazil, based on an analysis of their representations concerning health, disease, and treatment. Taking their living and working conditions as the background, the study sheds light on the strategies that allow them to adapt to social and family life, to obtain a livelihood, and to establish familiarity with the disease process. The article focuses particularly on the way such individuals deal with the problems of regaining their health, in addition to evaluating governmental and nongovernmental health services.

  4. Características clínico-laboratoriais no retratamento por recidiva em hanseníase Clinical and laboratory characteristics in the retreatment of leprosy relapse

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    Silvana Margarida Benevides Ferreira

    2012-09-01

    Full Text Available OBJETIVO: Comparar as características clínico-laboratoriais dos doentes de hanseníase durante o tratamento inicial e no retratamento por recidiva diagnosticada em unidades de saúde de referência no Estado de Mato Grosso MÉTODO: Estudo transversal de casos diagnosticados de recidiva em hanseníase em unidades de referência de 2005 a 2007 em cinco municípios do Estado. O tratamento inicial foi considerado t1 e a recidiva t2. Fontes de dados: Sistema de Informação de Agravos de Notificação, prontuários, exames laboratoriais, ficha de notificação individual e de avaliação de incapacidade física. Utilizou-se para a comparação e cálculo de proporções o teste do Qui-quadrado (c² ao nível de significância de 5%. RESULTADOS: Verificou-se predomínio da forma clínica dimorfa em t2 quando comparada a t1 (39,6% versus 11,3%; p = 0,003; 20,8%, dos casos em recidivas apresentaram índice baciloscópico ≥ 4+ se comparados aqueles em t1 (p = 0,034; aumento (17% dos casos de recidiva com grau zero de incapacidade quando comparados aos pacientes avaliados no momento do diagnóstico (58,5% versus 41,5%; aumento (7,5% de recidivas com incapacidades grau 2 quando comparadas a t1 (9,4% versus 1, 9%; predomínio de casos não avaliados quanto a incapacidade física entre t1 (45,3% e t2 (22,6%; (p = 0,040. CONCLUSÃO: Os casos de recidiva caracterizam o agravamento da doença indicadas pelo aumento do índice baciloscópico e do grau de incapacidade física. Recomenda-se maior atenção à confirmação diagnóstica de recidiva por meio de exames baciloscópicos, em especial nos multibacilares, e da avaliação neurológica sistemática de todos os pacientes de hanseníase.OBJECTIVE: To compare clinical and laboratory data of leprosy patients diagnosed in specialized services in the State of Mato Grosso, Brazil, during the initial treatment and the retreatment of relapse. METHODS: A cross-sectional study of patients with diagnosis of

  5. Avaliação do programa de controle da hanseníase em um município hiperendêmico do Estado do Maranhão, Brasil, 1991-1995

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    Aquino Dorlene Maria Cardoso de

    2003-01-01

    Full Text Available Estudo descritivo, objetivando avaliar o programa de controle da hanseníase do Município de Buriticupu, Maranhão. Foram analisados 214 prontuários de pacientes portadores das diversas formas clínicas de hanseníase, atendidos na unidade de saúde da Universidade Federal do Maranhão, localizada no referido município. A população de estudo foi constituída de 110 casos de hanseníase das formas paucibacilares (PB e 104 das formas multibacilares (MB registrados no período de janeiro de 1991 a dezembro de 1995. As informações referentes à forma clínica, número de contatos registrados, examinados e avaliados, grau de incapacidade no início e final do tratamento e situação de registro, foram coletadas num formulário específico. A análise dos resultados foi baseada nos parâmetros dos indicadores operacionais definidos pelo Ministério da Saúde. Houve um discreto predomínio da forma PB da doença. Observou-se baixos percentuais em relação aos pacientes com grau de incapacidade física avaliada no início e final do tratamento, a alta por cura e contatos examinados. O percentual de abandono foi elevado. O programa foi considerado "precário" em todos os indicadores utilizados para o estudo.

  6. Reação reversa atípica em paciente com hanseníase dimorfa co-infectado pelo HIV Atypical reversal reaction in a borderline leprosy patient co-infected with HIV

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    Rafaela de Lima Caruso

    2007-12-01

    Full Text Available A infecção pelo HIV não altera a história natural da hanseníase. Observa-se maior incidência de estados reacionais nos pacientes co-infectados, além de casos mais graves de neurite. Paciente soropositiva com hanseníase dimorfa tuberculóide manifestou reação reversa exuberante. Lesões cutâneas atípicas e raras surgiram após a introdução da terapia anti-retroviral que promoveu o início da recuperação imunológica com aumento de linfócitos T CD4+ e queda da carga viral. A restauração da imunidade celular nos pacientes soropositivos pode precipitar reações reversas, descritas recentemente como uma das manifestações da síndrome inflamatória de reconstituição imunológica associada à hanseníase.HIV infection does not modify the natural course of leprosy. However, HIV co-infection seems to be associated with an increased rate of reactional states and more severe cases of neuritis. The authors describe a case of borderline tuberculoid leprosy in a HIV-positive patient who developed a marked reversal reaction. Atypical and rare skin manifestations, such as verrucous lesions and ulcers, appeared after highly active antiretroviral therapy, which resulted in increased CD4+ T-lymphocyte count and drop in viral load. The restoration of the cellular immunity in HIV-seropositive patients can trigger reversal reactions that are one of the manifestations of the immune reconstitution inflammatory syndrome. Only recently the syndrome has been associated with leprosy.

  7. Aspectos da doença de hansen relevantes para o cirurgião-dentista: revisão da literatura = Relevant aspects of hansen’s disease to dentists: literature review

    Directory of Open Access Journals (Sweden)

    Russo, Michelle Pereira

    2005-01-01

    Full Text Available Tendo em vista o elevado número de casos de Doença de Hansen no Brasil, caracterizando um problema de saúde pública, o presente trabalho teve como objetivo realizar uma revisão bibliográfica visando informar o cirurgião-dentista sobre a situação atual da DH no Brasil, suas manifestações bucais, seqüelas que repercutem na saúde bucal e dar subsídios para que o profissional participe do diagnóstico desta doença

  8. Avaliação dos parâmetros de solubilidade de Hildebrand/Hansen na seleção de solventes para a extração de pesticidas organoclorados do solo

    OpenAIRE

    Ricardo D. Villa; Adriana P. Oliveira; Raquel F. Pupo Nogueira

    2011-01-01

    This work evaluated the use of the Hildebrand/Hansen solubility parameters for selection of solvents for extraction of the organochlorine pesticides pp' DDT, pp' DDE, Aldrin and a-Endossulfan from soil using columns packed with Al2O3. The mixtures hexane:dichloromethane (7:3; v/v), hexane:acetonitrile (1:1; v/v), hexane:acetone (1:1; v/v) and pure hexane were chosen as extracting solutions. In the addition and recovery tests, different extraction solutions provided high recoveries percentages...

  9. Validation of the Monte Carlo criticality program KENO IV and the Hansen-Roach sixteen-energy-group-cross sections for high-assay uranium systems. [KENO IV criticality code

    Energy Technology Data Exchange (ETDEWEB)

    Handley, G. R.; Masters, L. C.; Stachowiak, R. V.

    1981-04-10

    Validation of the Monte Carlo criticality code, KENO IV, and the Hansen-Roach sixteen-energy-group cross sections was accomplished by calculating the effective neutron multiplication constant, k/sub eff/, of 29 experimentally critical assemblies which had uranium enrichments of 92.6% or higher in the uranium-235 isotope. The experiments were chosen so that a large variety of geometries and of neutron energy spectra were covered. Problems, calculating the k/sub eff/ of systems with high-uranium-concentration uranyl nitrate solution that were minimally reflected or unreflected, resulted in the separate examination of five cases.

  10. Subtipos do antígeno Austrália (HBsAg em doentes de hanseníase de São Paulo, Brasil Subtypes of Australia antigen (HBsAg in leprosy

    Directory of Open Access Journals (Sweden)

    Sandra Ottati

    1979-12-01

    Full Text Available Foram examinados 135 soros de pacientes com hanseníase para identificação dos subtipos ad e ay de HB sAg, tendo-se encontrado somente 3 casos positivos para o antígeno Austrália, todos eles do subtipo ad (2,2%.One hundred and thirty five sera from patients with leprosy were tested for the ad and ay subtypes of HBsAg. Only three (2,2% had HBsAg and all were ad positive.

  11. Hanseníase em menores de 15 anos: a importância do exame de contato Enfermedad de Hansen en menores de 15 años: la importancia del examen de contacto Leprosy in children under 15 years: the importance of early diagnosis

    Directory of Open Access Journals (Sweden)

    Carla Andrea A. Pires

    2012-06-01

    Full Text Available OBJETIVO: Descrever dois casos de hanseníase em menores de 15 anos, sendo um de paciente com 18 meses de idade e outro de 13 anos, diagnosticados por modos de detecção diferentes, ressaltando a importância de examinar os contatos. DESCRIÇÃO DO CASO: Um dos casos foi diagnosticado precocemente por meio do exame de contatos intradomiciliares, enquanto o outro foi diagnosticado por demanda espontânea após quatro anos de aparecimento das lesões e, apesar de ser contato de um ex-paciente, não foi examinado na época. COMENTÁRIOS: Em países endêmicos, a alta detecção da hanseníase em menores de 15 anos revela a persistência na transmissão do bacilo e as dificuldades dos programas de saúde para o controle da doença. O maior tempo para diagnóstico ocasiona sequelas e deformidades e, dessa forma, a busca dos contatos constitui importante método para o diagnóstico precoce da doença na infância, quando os sinais clínicos nem sempre são fáceis de serem identificados e há grande diversidade de formas clínicas em que a doença pode se apresentar.OBJETIVO: Describir dos casos de enfermedad de Hansen en menores de 15 años, siendo uno de paciente con 18 meses de edad y otro de 13 años, diagnosticados por modos de detección distintos, subrayando la importancia de examinar a los contactos. DESCRIPCIÓN DEL CASO: Uno de los casos tuvo diagnóstico temprano mediante examen de contactos intradomiciliares, mientras que el otro fue diagnosticado por demanda espontánea después de cuatro años de surgimiento de las lesiones y, a pesar de ser contacto de un ex-paciente, no fue examinado en la época. COMENTARIOS: En países endémicos, la alta detección de enfermedad de Hansen en menores de 15 años revela la persistencia en la transmisión del bacilo y las dificultades de los programas de salud para el control de la enfermedad. El mayor tiempo para diagnóstico ocasiona secuelas y deformidades y, de ese modo, la búsqueda por los

  12. A New Economic and Political State of Play in the Energy Sector: On Jean-Pierre Hansen and Jacques Percebois, Energy. Economy and politics; Energie: nouvelle donne economique et politique. A propos du livre de Jean-Pierre Hansen et Jacques Percebois, Energie. Economie et politiques

    Energy Technology Data Exchange (ETDEWEB)

    Lesourne, J. [Association Futuribles International, 75 - Paris (France)

    2011-04-15

    If there is one sector in which the state of play has changed radically over a few decades, it is the energy sector. It has been affected simultaneously by the prospect that the main fossil fuels will become exhausted, by the impact on our planet's climate of the consumption of this fossil energy (implying increased recourse to renewable sources) and by the rapid economic development of large nations consuming increasing quantities of energy. Energy-related policies (particularly economic and technological policies) are, in fact, being developed in an increasingly complex and international context, which is, at times, very difficult to grasp. Fortunately, two specialists in energy matters, Jean-Pierre Hansen and Jacques Percebois, have published a very comprehensive survey of this new economic and political state of play in the energy field: 'Energie. Economie et politiques' [Energy: Economics and Policies] (Brussels: De Boeck, 2010). It clearly is not possible here to go into all the questions they confront, but in this review Jacques Lesourne, who has read the book for Futuribles, clearly demonstrates its importance and presents the reader with the main facets of the work that make it a reference tool for all involved in this sector, including the most highly specialized. (author)

  13. Perfil dos pacientes com hanseníase em área hiperendêmica da Amazônia do Maranhão, Brasil

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    Aquino Dorlene Maria Cardoso de

    2003-01-01

    Full Text Available Estudo transversal, realizado de agosto/1998 a novembro/2000, envolvendo 207 pacientes hansenianos com o objetivo de analisar o perfil socioeconômico, demográfico e ambiental e as incapacidades físicas em decorrência da doença. O estudo foi desenvolvido em Buriticupu, área hiperendêmica em hanseníase, localizado na Amazônia do Maranhão. O grau de incapacidade foi determinado de acordo com o Ministério da Saúde do Brasil. A avaliação clínica e os resultados do exame físico foram registrados em uma ficha padronizada. Observou-se predomínio de pessoas casadas (45,9%, com escolaridade de 1masculine grau (56%, lavradores (40,1%, com renda familiar inferior a um salário mínimo (76,3%, na faixa etária de 14 a 44 anos (63,3%, do gênero masculino (60,9% e da cor parda (67,6%. 44% residiam em casa de taipa, 82,6% destinavam os dejetos em fossa negra, 63,8% lançavam o lixo a céu aberto, 58% utilizavam água proveniente de poço e 51,7% não tratavam a água utilizada para ingestão. A maioria (75,4% apresentava algum grau de incapacidade física, sendo predominante o Grau I (67,6%. Os segmentos mais afetados foram pés (62,3%, olhos (51,2% e mãos (7,2%, sendo o maior percentual de incapacidades físicas observado entre os da forma dimorfa (93% principalmente em mãos e pés, e na forma virchowiana maior freqüência de incapacidades oculares. Conclui-se que a hiperendemicidade associada a precárias condições socioeconômicas e ao elevado índice de incapacidades físicas podem interferir na qualidade de vida dos pacientes.

  14. Instrumento para avaliação das ações de controle da hanseníase na Atenção Primária

    Directory of Open Access Journals (Sweden)

    Fernanda Moura Lanza

    2014-06-01

    Full Text Available O estudo teve como objetivo construir e validar um instrumento de avaliação das ações de controle da hanseníase na atenção primária na perspectiva dos agentes comunitários de saúde (ACS. Trata-se de um estudo metodológico para validação de instrumentos, fundamentado na Teoria Clássica dos Testes. O instrumento foi aplicado a 380 ACS de três municípios do estado de Minas Gerais, no período de julho a dezembro de 2012. Na etapa de validação de face e conteúdo foram reduzidos 17 itens do instrumento. A análise fatorial extraiu oito fatores que responderam por um percentual de 35,7% da variância total. A análise dos componentes principais permitiu a eliminação de oito itens que não apresentaram adequação aos fatores definidos. O alfa de Cronbach geral para os 57 itens foi de 0,858. Conclui-se que o instrumento é válido para avaliar o desempenho da atenção primária no controle da hanseníase segundo a experiência dos ACS.

  15. Ação educativa sobre hanseníase na população usuária das unidades básicas de saúde de Uberaba-MG

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    Ana Jotta Moreira

    Full Text Available O objetivo do estudo foi o de avaliar o efeito de uma intervenção educativa sobre o conhecimento acerca da hanseníase em usuários das Unidades Básicas de Saúde de Uberaba-MG. Trata-se de pesquisa de intervenção de natureza descritiva, com abordagem quantitativa. Aplicou-se questionário antes e após a intervenção educativa, que abordou sinais e sintomas, meios de transmissão, complicações e tratamento da hanseníase. Participaram 88 mulheres e oito homens com idade média de 57,06±1,79 anos. Observou-se que ainda é grande a desinformação da população. No entanto, a importância da estratégia de educação em saúde pôde ser confirmada pelo satisfatório acréscimo de conhecimento, favorecendo a prevenção e diagnóstico precoce.

  16. Luta pela sobrevivência: a vida de um hanseniano através da correspondência com Adolpho Lutz Fight for survival: the life of a Hansen's disease sufferer through his correspondence with Adolpho Lutz

    Directory of Open Access Journals (Sweden)

    Jaime Larry Benchimol

    2003-01-01

    Full Text Available O presente trabalho apresenta a série completa da correspondência da família de um portador do mal de Hansen residente no Maranhão, Nordeste do Brasil, com o médico e bacteriologista Adolpho Lutz. Fabrício Caldas de Oliveira e Numa Pires de Oliveira, pai e filho, mantiveram durante mais de vinte anos intensa troca de cartas com o cientista na busca da cura da doença que vitimava Numa desde criança. As 24 cartas aqui reunidas retratam, de maneira única, o drama médico-social enfrentado por esta família, os resultados do uso do chalmugra e outros medicamentos, a busca de tratamentos alternativos.This project presents the complete set of letters between the family of a Hansen's disease (leprosy sufferer in the state of Maranhão, in the northeast of Brazil, and the doctor and bacteriologist Adolpho Lutz. For more than twenty years Fabrício Caldas de Oliveira and Numa Pires de Oliveira, father and son, exchanged a steady flow of letters with the scientist in pursuit of a cure for the disease that had assailed Numa since childhood. The 24 letters compiled here paint a unique portrait of the medical and social drama confronted by this family, and the results of the use of chaulmoogra oil and other medications in their search for alternative treatments.

  17. Perfil epidemiológico da hanseníase em um município brasileiro, no período de 2000 a 2006 Epidemiological profile of leprosy in a Brazilian municipality between 2000 and 2006

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    Sybelle de Souza Castro Miranzi

    2010-02-01

    Full Text Available INTRODUÇÃO: A hanseníase é considerada um grande problema de saúde pública nos países em desenvolvimento. Estima-se que somente 1/3 dos doentes sejam notificados e que, dentre esses, muitos fazem tratamento irregular ou o abandonam, aumentando o impacto da doença. Assim o objetivo desse artigo foi descrever o perfil epidemiológico da população com diagnóstico de hanseníase, no município de Uberaba, Estado de Minas Gerais, Brasil, no período de 2000 a 2006. MÉTODOS: Trata-se de um estudo retrospectivo, que utilizou os dados secundários de notificação de casos hanseníase do Sistema de Informação de Agravos de Notificação do Ministério da Saúde do Brasil. RESULTADOS: Foram registrados 455 casos da doença, sendo 55,4% do sexo masculino, a faixa etária dos 34 a 49 anos (31,4 % foi a mais afetada, houve registro de nove (2% casos de hanseníase em menores de 15 anos. A forma clínica prevalente foi a dimorfa (69,1% e a classe operacional foi a multibacilar (87%. Tais achados são preocupantes, considerando-se que são de faixa etária economicamente ativa e potencialmente, os principais disseminadores da doença. CONCLUSÕES: O relato de que a maioria dos casos eram multibacilares, indica diagnósticos tardios, assim, torna-se necessário descentralizar o serviço de hanseníase e capacitar mais profissionais para possibilitar diagnóstico e tratamentos mais precoces.INTRODUCTION: Leprosy is considered to be a major public health problem in developing countries. It is estimated that notifications are issued only in relation to 1/3 of the patients and that, among these patients, many undergo irregular treatment or drop out, thus increasing the impact of the disease. The objective this paper was to describe the epidemiological profile of the population with a diagnosis of leprosy in the municipality of Uberaba, State of Minas Gerais, Brazil, between 2000 and 2006. METHODS: This was a retrospective study using data from

  18. Various faces of Hansen's disease.

    Science.gov (United States)

    Raval, R C

    2012-01-01

    Leprosy is a chronic granulomatous disease caused by Mycobacterium leproe. Leprosy once considered a taboo is still misdiagnosed and underdiagnosed. In many cases leprosy is treated as common disorders like psoriasis, pyoderma, angioedema, pre vitiligo. Leprosy can present in many diverse ways which can be confused with many treatable and non treatable, infectious and non infectious forms. Leprosy is considered on the verge of elimination. But Leprosy cases are being newly diagnosed day by day. Here we are presenting 4 atypical cases of leprosy which did not seem to have classical presentation but were diagnosed as leprosy when investigated.

  19. Humoral immunity in Hansen's Disease

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    Waldenise Cossermelli-Messina

    Full Text Available For many years immune response in leprosy has been studied. Since 1960 several reports dealing with humoral immunity have been described in the literature. Different autoantibody rates occur in leprosy. There is an increase in the prevalence of autoantibodies in elderly patients with long standing disease, in lepromatous leprosy and in those with reactional states. The diferences in rates among various studies are attributed to different methods and variations among patient samples concerning age, gender, polar forms, therapy and other elements. The prevalence of numerous antibodies, immune complexes, cryoglobulins and complement levels have been studied by many authors. This also highlights the importance of the more recent reviews of anti-Mycobacterium leprae glycolipid antibodies such as the anti-phenolic glycolipid-I antibodies in which titers are variable and depend on genetic factors.

  20. Presidendi kahtlased ettepanekud / Vootele Hansen

    Index Scriptorium Estoniae

    Hansen, Vootele, 1962-

    2002-01-01

    Autor kommenteerib president Arnold Rüütli mõtteavaldust, et Eesti elanikud võiks oma säästud suunata põlevkivi kütvate elektrijaamade uuendamisse. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik

  1. Hansen Cleaning Solvent Research Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Environmental regulation will force current baseline  precision cleaning solvent (AK-225) to be phased out starting 2015. We plan to develop  a new...

  2. Unnatural Narratology. Basic Concepts and Recent Work [Jan Alber / Rüdiger Heinze: Unnatural Narratives – Unnatural Narratology. Berlin 2011. Per Krogh Hansen / Stefan Iversen / Henrik Skov Nielsen / Rolf Reitan (Eds.: Strange Voices in Narrative Fiction. Berlin 2011. David Herman / James Phelan / Peter Rabinowitz / Brian Richardson / Robyn Warhol: Narrative Theory: Core Concepts and Critical Debates. Columbus 2012

    Directory of Open Access Journals (Sweden)

    Brian Richardson

    2012-12-01

    Full Text Available Rezension zu / Review of:Jan Alber / Rüdiger Heinze: Unnatural Narratives – Unnatural Narratology. Berlin 2011. Per Krogh Hansen / Stefan Iversen / Henrik Skov Nielsen / Rolf Reitan (Eds.: Strange Voices in Narrative Fiction. Berlin  2011. David Herman / James Phelan / Peter Rabinowitz / Brian Richardson / Robyn Warhol: Narrative Theory: Core Concepts and Critical Debates. Columbus 2012.

  3. 30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

  4. Fatores associados à recidiva em hanseníase em Mato Grosso Factores asociados a recidiva en hanseníasis en Mato Grosso, Centro-oeste de Brasil Factors associated to relapse of leprosy in Mato Grosso, Central-Western Brazil

    Directory of Open Access Journals (Sweden)

    Silvana Margarida Benevides Ferreira

    2011-08-01

    Full Text Available OBJETIVO: Analisar fatores associados à ocorrência de recidiva em hanseníase. MÉTODOS: Estudo retrospectivo caso-controle com 159 pacientes maiores de 15 anos diagnosticados com hanseníase em cinco municípios do estado de Mato Grosso, cujas unidades de saúde eram consideradas de referência para o atendimento. O grupo de casos incluiu 53 indivíduos com recidiva de 2005 a 2007 e foi comparado ao grupo controle (106 com alta por cura em 2005, pareados por sexo e classificação operacional. Foram usados dados do Sistema de Informação de Agravos de Notificação, prontuários e entrevistas. Utilizou-se regressão logística condicional e abordagem hierárquica. RESULTADOS: Após análise ajustada, mostraram-se associados à ocorrência de recidiva: indivíduos residentes em casas alugadas (OR = 4,1; IC95%:1,43;12,04, em domicílio de madeira/taipa (OR = 3,2; IC95%: 1,16;8,76, que moravam com mais de cinco pessoas (OR = 2,1; IC95% : 1,03;4,36, com transtorno de uso de álcool (OR = 2,8; IC95%: 1,17;6,79, irregularidade do tratamento (OR = 3,8;IC95%: 1,44;10,02, sem esclarecimento sobre a doença/tratamento (OR = 2,6; IC95%: 1,09;6,13, que usavam transporte coletivo para o acesso à unidade de saúde (OR = 5,5; IC95%: 2,36;12,63, forma clínica da doença (OR = 7,1; IC95%: 2,48;20,52 e esquema terapêutico (OR = 3,7; IC95%: 1,49;9,11. CONCLUSÕES: Os fatores preditivos de recidiva relacionam-se com condições de moradia, hábitos de vida, organização dos serviços de saúde, formas clínicas e esquemas terapêuticos. Cabe aos serviços de saúde oferecer orientações adequadas aos pacientes, bem como garantir a regularidade do tratamento.OBJETIVO: Analizar factores asociados a la ocurrencia de recidiva en hanseníasis. MÉTODOS: Estudio retrospectivo caso-control con 159 pacientes mayores de 15 años diagnosticados con hanseníasis en cinco municipios del Estado de Mato Grosso, Centro-oeste de Brasil, cuyas unidades de salud eran

  5. Distribuição espacial da hanseníase no município de Mossoró/RN, utilizando o Sistema de Informação Geográfica - SIG Spatial Distribuition of hansen disease in the municipality of Mossoró/RN, using the Geographic Infromation System - (GIS

    Directory of Open Access Journals (Sweden)

    Márcia Célia Freitas de Souza Dias

    2005-12-01

    Full Text Available FUNDAMENTOS/OBJETIVO: O município de Mossoró, no Estado do Rio Grande do Norte, tem um elevado coeficiente de detecção de hanseníase, que passou de 2,78 em 1998 para 5,08 casos novos por 10.000 habitantes em 2002. O registro de casos vem ocorrendo em toda a zona urbana, porém com maior concentração em alguns bairros. Esse trabalho foi realizado utilizando-se o Sistema de Informações Geográficas (SIG com o objetivo de determinar a localização espacial da doença, buscando um melhor entendimento da endemia no município. MATERIAL E MÉTODOS/CASUÍSTICA: O estudo foi realizado na área urbana de Mossoró e utilizou como bases cartográficas o mapa cadastral da cidade e imagem de satélite Ikonos, além do banco de dados do SINAN (Sistema de Informação de Agravos de Notificação. Foram selecionados 358 casos novos da doença diagnosticados entre 1998 e 2002 para georreferenciamento dos seus endereços usando-se um aparelho GPS (Magellan 320. A análise geográfica foi feita através do ArcView 9.0. RESULTADOS/DISCUSSÃO: Foram localizados os endereços de 281 pacientes (78,5% do total com grande concentração nos bairros de Barrocas, Santo Antônio, Bom Jardim e Paredões. O mapeamento serviu de base para a realização de campanha para diagnóstico, especialmente direcionada para áreas mais endêmicas, levando ao diagnóstico de 30 casos novos da doença em apenas uma semana (ou 27% de todos os casos novos do município em 2004. CONCLUSÃO: O uso do SIG na hanseníase se mostrou extremamente eficaz, proporcionando o entendimento espacial da distribuição da doença no município e direcionando a execução de ações de controle com importante redução de custos.BACKGROUND / OBJECTIVES: The Municipality of Mossoró, in Rio Grande do Norte State in Brazil, has a high incidence of Hansen's disease (HD. New case detection rate has increased from 2.78 in 1998 to 5.08 new cases per 10.000 population in 2002. New patients have been

  6. Clinical and epidemiological study of leprosy cases in the University Hospital of Brasília: 20 years - 1985 to 2005 Estudo clínico-epidemiológico dos casos de hanseníase do Hospital Universitário de Brasília: 20 anos - 1985 a 2005

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    Gerson Oliveira Penna

    2008-12-01

    Full Text Available Hansen's disease, also known as leprosy, is an infectious disease still prevalent in Brazil. It is a chronic illness with acute immunological phenomena known as leprosy reactions. In the Federal District of Brazil, the University Hospital of Brasília is the reference centre for leprosy care. The study aimed to characterize the clinical and epidemiological profile of Hansen's disease patients at the University Hospital of Brasília, by descriptive, retrospective analysis of 1,124 patients over the period from 1985 to 2005. The pattern of leprosy in this study demonstrated that type 2 leprosy reactions were common, especially in the lepromatous form and presented a direct correlation with the bacilloscopic index. The prevalence and frequency of severe complications, such as leprosy reactions, emphasize the importance of the ongoing study of leprosy and the need for continual improvement in the scope of knowledge concerning its treatment.Hanseníase, também conhecida como lepra, é doença infecciosa prevalente no Brasil. Caracteriza-se por curso crônico, com fenômenos imunológicos agudos denominados episódios reacionais. No Distrito Federal, o Hospital Universitário de Brasília é referência na assistência da hanseníase. O objetivo do estudo foi caracterizar o perfil clínico-epidemiológico dos doentes portadores de hanseníase do Hospital Universitário de Brasília. Foi realizada análise descritiva e retrospectiva de 1124 doentes portadores de hanseníase no período de 1985 a 2005. O padrão da hanseníase no nosso estudo concretizou-se por apresentar maior prevalência de reações do tipo 2, especialmente na forma lepromatosa e correlacionando-se diretamente com o índice baciloscópico. A significativa prevalência e freqüência de complicações graves como os episódios reacionais ressaltam a importância do estudo da doença e a necessidade de aprimoramento contínuo dos conhecimentos sobre a mesma.

  7. A Via Sacra da Hanseníase de Veganin La Via Sacra de la Lepra de Vaganin Veganin's Leprosy Via Sacra

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    Nadja Cristiane Lappann Boti

    2008-11-01

    Full Text Available Foi realizada pesquisa histórica com análise documental e história oral objetivando descrever a biografia e analisar a pintura de Veganin. Luiz Carlos de Souza nasceu em 1950 em Aimorés (MG e aos 16 anos foi trabalhar na enfermagem na Santa Casa de Misericórdia de Belo Horizonte. Com 20 anos foi internado na Colônia Santa Isabel (MG e passou a ser conhecido como " Veganin" . Na Colônia trabalhou na enfermagem, marcenaria e pintura. Pintou no estilo da Pop Art os quadros da Via Sacra onde mostra a Paixão de Cristo com originalidade e crítica social. Nos quadros apresenta sua resiliência frente à hanseníase e ao tratamento. Faleceu na Colônia Santa Fé (MG em 1997.La investigación histórica se llevó a cabo con análisis documental y la historia oral con el objetivo de describir la biografía y la revisión de la pintura de Veganin. Luiz Carlos de Souza nació en 1950 en Aimorés (MG y a la edad de 16 años estaba trabajando en enfermería en la Santa Casa de Misericordia de Belo Horizonte. Con 20 años fue hospitalizado en Colônia Santa Isabel y que ahora se conoce como " Veganin" . En Colônia trabajado en enfermería, carpintería y pintura. Pintó en el estilo Pop Art de los cuadros del Vía Sacra, donde se muestra la Pasión de Cristo con la originalidad y la crítica social.Los cuadros muestran su resistencia en relación la enfermedad y el tratamiento. Muerto en Colônia Santa Fé (MG en 1997.Historical research was carried out with documentary analysis and oral history aiming at describing the biography and reviewing the painting of Veganin. Luiz Carlos de Souza was born in 1950 in Aimorés (MG and at age of 16 years he was working in nursing at the Santa Casa de Misericórdia in Belo Horizonte. With 20 years he was hospitalized in Colônia Santa Isabel and is now known as " Veganin" . In Colônia worked in nursing, carpentry and painting. He painted in the style of Pop Art the tables's Via Sacra where shows the Passion of

  8. Neuropatia silenciosa em portadores de hanseníase na cidade de Fortaleza, Ceará, Brasil Silent neuropathy in patients with leprosy in the city of Fortaleza, Ceará State, Brazil

    Directory of Open Access Journals (Sweden)

    Vyna Maria Cruz Leite

    2011-04-01

    Full Text Available Uma das formas da hanseníase é a neuropatia silenciosa que consiste em perda progressiva da função motora ou sensorial na ausência de dor e hipersensibilidade dos nervos. Realizou-se um estudo transversal em Fortaleza, Ceará, Brasil, o qual estimou a proporção de neuropatia silenciosa e fatores associados. O paciente foi interrogado sobre a presença de dor, dormência, alteração da sensibilidade, e foi realizada palpação de nervos para identificar espessamento, abscesso e dor. Amostras de linfa foram obtidas para exames parasitológicos. Foi medida a força de músculos voluntários dos membros e a sensibilidade de pontos das mãos e dos pés por meio de monofilamentos de Semmes-Weinstein. De uma amostra de 233 portadores de hanseníase, a proporção de pacientes com neuropatia silenciosa foi 5,6% (IC95%: 3,0-9,4, e a ocorrência de neuropatia silenciosa esteve significativamente associada à idade (p = 0,011 e à incapacidade (p One of the clinical forms of Hansen's disease is silent neuropathy, which consists of progressive nerve damage in the absence of pain and hypersensitivity to palpation. This study estimated the proportion of silent neuropathy and associated factors. A cross-sectional study was performed in Fortaleza, Ceará State, Brazil. Patients were asked about the presence of decreased sensation involving touch, heat, pain, and numbness. Nerves were palpated to identify thickness, abscess, and pain. Lymph samples were drawn for parasitological tests. Strength of voluntary muscles in the feet and hands was evaluated. The sensitivity of specific points on the feet and hands was measured using Semmes-Weinstein monofilament. The sample included 233 patients. The proportion of silent neuropathy was 5.6% (95%CI: 3.0-9.4, and factors significantly associated with silent neuropathy were: age (p = 0.011 and disability (p < 0.000. These results will help identify cases of silent neuropathy, targeting patients at higher risk.

  9. Late Holocene earthquake history of the Brigham City segment of the Wasatch fault zone at the Hansen Canyon, Kotter Canyon, and Pearsons Canyon trench sites, Box Elder County, Utah

    Science.gov (United States)

    DuRoss, Christopher B.; Personius, Stephen F.; Crone, Anthony J.; McDonald, Greg N.; Briggs, Richard W.

    2012-01-01

    Of the five central segments of the Wasatch fault zone (WFZ) having evidence of recurrent Holocene surface-faulting earthquakes, the Brigham City segment (BCS) has the longest elapsed time since its most recent surface-faulting event (~2.1 kyr) compared to its mean recurrence time between events (~1.3 kyr). Thus, the BCS has the highest time-dependent earthquake probability of the central WFZ. We excavated trenches at three sites––the Kotter Canyon and Hansen Canyon sites on the north-central BCS and Pearsons Canyon site on the southern BCS––to determine whether a surface-faulting earthquake younger than 2.1 ka occurred on the BCS. Paleoseismic data for Hansen Canyon and Kotter Canyon confirm that the youngest earthquake on the north-central BCS occurred before 2 ka, consistent with previous north-central BCS investigations at Bowden Canyon and Box Elder Canyon. At Hansen Canyon, the most recent earthquake is constrained to 2.1–4.2 ka and had 0.6–2.5 m of vertical displacement. At Kotter Canyon, we found evidence for two events at 2.5 ± 0.3 ka and 3.5 ± 0.3 ka, with an average displacement per event of 1.9–2.3 m. Paleoseismic data from Pearsons Canyon, on the previously unstudied southern BCS, indicate that a post-2 ka earthquake ruptured this part of the segment. The Pearsons Canyon earthquake occurred at 1.2 ± 0.04 ka and had 0.1–0.8 m of vertical displacement, consistent with our observation of continuous, youthful scarps on the southern 9 km of the BCS having 1–2 m of late Holocene(?) surface offset. The 1.2-ka earthquake on the southern BCS likely represents rupture across the Weber–Brigham City segment boundary from the penultimate Weber-segment earthquake at about 1.1 ka. The Pearsons Canyon data result in a revised length of the BCS that has not ruptured since 2 ka (with time-dependent probability implications), and provide compelling evidence of at least one segment-boundary failure and multi-segment rupture on the central WFZ. Our

  10. On Melody and Poetry——an Analysis of the Inherent "Language" of Music in Wagner's Creative Theory%论旋律与诗歌——解析瓦格纳创作理论中音乐自身的“语言”元素

    Institute of Scientific and Technical Information of China (English)

    赵青

    2012-01-01

    瓦格纳戏剧性的艺术风格是语言的描述力在歌剧音乐里的具体体现,他发现了音乐自身的"语言"元素,并且用音乐作品证明了音乐与语言所具有的要素是通用的,证明了如果使用这些要素可以使音乐达到戏剧性的效果。可以从语言与情感、音调语言和词字语言、旋律与诗歌即诗歌与旋律的合理关系三个方面来解析瓦格纳创作理论中音乐自身的语言问题。%Wagner's dramatic artistic style is the concrete embodiment of linguistic description in opera music who discovered the inherent language of music and proved that the elements in music and language can be communal and the music would get a dramatic effect if these elements are applied.This paper analyzes the inherent "language" of music in Wagner's creative theory from three aspects as that of language and sentiment,tonal language and pictographic language,and melody and poetry.

  11. Kariogram dan Peranannya dalam Meramalkan Kemungkinan Terjadinya Karies

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    Safrida Hoesin

    2015-08-01

    Full Text Available Cariogram is an instrument which was prepared to estimate caries occurrence among the 18 years old (Branthall et al. 1996. In the Cariogram, parameters of caries interation were consist of diet, susceptible tooth, bacteria and circumstances. However, some of the points in parameters such as colony count and topical fluoride or water fluoridation were not widely known in Indonesia. The aim of this report is to modify a Cariogram for the 12 year old children based on an epidemiological observation which subjects were selected in a randomized stratified sampling. The data were analysed in a multiple logistic regression technique. As a result of the study revealed that new parameters of a modified Cariogram model were slightly different from the original: however, it could be introduced as a model of caries reduction to support the national promotive and preventice program.

  12. Google Forms aitab treeningpäevikut luua / Karis Niisuke

    Index Scriptorium Estoniae

    Niisuke, Karis

    2015-01-01

    1.09.2015 riigigümnaasiumina alustanud Jõhvi Gümnaasium seadis õpetajad uude olukorda, tuli leida toimivad lahendused muutunud õppekorraldusega toimetulekuks. Nii sündis veebipõhise treeningpäeviku lahendus Google’i vormi näol, millele lisandus ka My Music Memory - õpilaste isiklikud veebipõhised päevikud aineoskuste väljaselgitamiseks, tegevuste ja teadmiste arhiveerimiseks, reflekteerimiseks ja analüüsimiseks õpetaja veebipõhisel toel ning suunamisel

  13. POLA KARIES PENDERITA KARSINOMA NASOFARING YANG MEMPEROLEH TERAPI RADIASI

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    Ratna Meidyawati

    2015-07-01

    Full Text Available Therapy of radiation is chosen therapy for oral cancer especially Carcininoma Nasopharynx, however, often caused changes in normal tissue in the oral cavity. Based on the anamneses of the patient, they have dry mouth since the disturbance of the function of parotid salivary gland has causing the saliva amount become lower. This condition can encourage the caries process. From all of the five cases occurred after the radiation between one month until six years the time, extended damage is seen, demineralization with a small cavity, and discoloring teeth color into brown.

  14. TERAPI PENGGANTIAN STRAIN SEBAGAI ALTERNATIF PENCEGAHAN KARIES GIGI

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    Retno Indrawati Roestamadji

    2015-07-01

    Full Text Available Dental caries is a unique multifactorial infectious disease. In recent years, the prevalence of dental caries in most western countries has steadily declined. By contrast study done in some developing countries such as Zambia, Nigeria, Thailand and Indonesia showed a marked increase in dental caries. Streptococcus mutans (S. mutans is the most important agent of human caries. Cariogenic feature of these bacteria include synthesis intracellular polysaccharide, extracellular polysaccharide, lactic acid production and ability to survive in low pH levels. Potentially, caries can be reduced by interfering with transmission of S . mutans, eliminating established S. mutanspopulations from the oral cavity, increasing the acid resistance of the teeth and control and control of the carbohydrate composition of the diet. Oral anti mutans vaccines have been demonstrated in the laboratory, the costs involved in the development for human are relatively high. Studies Strain replacement therapy is a great promise in implantation of benign oral microbial strain capable of successfully competing with S. mutans.

  15. Google Forms aitab treeningpäevikut luua / Karis Niisuke

    Index Scriptorium Estoniae

    Niisuke, Karis

    2015-01-01

    1.09.2015 riigigümnaasiumina alustanud Jõhvi Gümnaasium seadis õpetajad uude olukorda, tuli leida toimivad lahendused muutunud õppekorraldusega toimetulekuks. Nii sündis veebipõhise treeningpäeviku lahendus Google Forms näol

  16. Wina bez kary – o bezkarności manipulatora

    OpenAIRE

    Łukowski, Piotr

    2015-01-01

    Wielu wybitnych psychologów, takich jak Philip Zimbardo czy Simon Baron-Cohen, stawia fundamentalne pytanie: Jak dobrzy ludzie mogą skłaniać się do zła? Odpowiedź na nie powinna być przedmiotem zainteresowania i stanowić ważny temat również dla prawników. Oczywiście czasami istnieją takie sytuacje, kiedy tzw. dobrzy ludzie stają się sprawcami przestępstwa. Niektóre z tych sytuacji wcale nie są przypadkowe, lecz kreowane przez kogoś, kto dobrze zna metody manipulowania innymi ludźmi. Wówczas m...

  17. Google Forms aitab treeningpäevikut luua / Karis Niisuke

    Index Scriptorium Estoniae

    Niisuke, Karis

    2015-01-01

    1.09.2015 riigigümnaasiumina alustanud Jõhvi Gümnaasium seadis õpetajad uude olukorda, tuli leida toimivad lahendused muutunud õppekorraldusega toimetulekuks. Nii sündis veebipõhise treeningpäeviku lahendus Google Forms näol, millele lisandus ka My Music Memory - õpilaste isiklikud veebipõhised päevikud aineoskuste väljaselgitamiseks, tegevuste ja teadmiste arhiveerimiseks, reflekteerimiseks ja analüüsimiseks õpetaja veebipõhisel toel ning suunamisel

  18. Van Wijngaarden grammars, metamorphism and K-ary malwares

    CERN Document Server

    Gueguen, Geoffroy

    2010-01-01

    Grammars are used to describe sentences structure, thanks to some sets of rules, which depends on the grammar type. A classification of grammars has been made by Noam Chomsky, which led to four well-known types. Yet, there are other types of grammars, which do not exactly fit in Chomsky's classification, such as the two-level grammars. As their name suggests it, the main idea behind these grammars is that they are composed of two grammars. Van Wijngaarden grammars, particularly, are such grammars. They are interesting by their power (expressiveness), which can be the same, under some hypotheses, as the most powerful grammars of Chomsky's classification, i.e. Type 0 grammars. Another point of interest is their relative conciseness and readability. Van Wijngaarden grammars can describe static and dynamic semantic of a language. So, by using them as a generative engine, it is possible to generate a possibly infinite set of words, while assuring us that they all have the same semantic. Moreover, they can describe...

  19. Attitudes towards English in Ghana Kari Dako Millicent Akosua ...

    African Journals Online (AJOL)

    high schools and colleges of education suggests that Oral English is no longer part of the ... variety markers are recurrent in almost all genres of written discourse. ... handicap, but that bilingualism in English and a local language(s) might be ...

  20. Prevenção de incapacidade na hanseníase com apoio em um manual de autocuidado para pacientes Disability prevention in leprosy using a self-care manual for patients

    Directory of Open Access Journals (Sweden)

    Fernanda Carvalho Batista Rodini

    2010-06-01

    Full Text Available A hanseníase é uma doença infectocontagiosa, de evolução lenta, que se manifesta por sinais e sintomas dermatoneurológicos, com lesões na pele e nos nervos periféricos. O objetivo deste estudo foi avaliar o status físico e funcional de olhos, mãos e pés de pacientes com hanseníase, em relação ao aparecimento e evolução de deficiências sensitivo-motoras, grau de incapacidade e qualidade de vida, tendo os pacientes recebido e utilizado durante um ano um manual especialmente elaborado, com orientações de autocuidados para prevenção de incapacidade. Foram realizadas e comparadas avaliações fisioterapêuticas inicial e após 12 meses de uso do manual, de 26 pacientes com hanseníase: palpação de nervos periféricos, teste de sensibilidade da córnea, teste de sensibilidade cutânea, teste manual de função muscular e dinamometria isométrica de preensão e pinças dos dedos, sendo aplicado ainda o questionário de qualidade de vida SF-36 e classificado o grau de incapacidade. Os nervos mais acometidos foram o ulnar e o tibial posterior. Embora o grau de incapacidade e as deformidades preexistentes tenham persistido, houve melhora significativa nos domínios dor e aspectos sociais do questionário SF-36, bem como na função muscular das mãos e dos pés e no ressecamento da pele. Como estas últimas são diretamente relacionadas ao autocuidado, sugere-se que o manual de orientações pode ter importante papel coadjuvante na melhora de sintomas dos pacientes com hanseníase.Leprosy is an infectious disease of slow evolution, manifested by dermatoneurological signs and symptoms, with skin and peripheral nerve injuries. The aim of this study was to assess physical and functional status of eyes, hands and feet of patients with leprosy, as well as to assess evolution of sensory-motor disabilities, degree of disability and quality of life, having specially produced and handed the patients an illustrated self-care manual for

  1. Aspectos estomatológicos das lesões específicas e não-específicas em pacientes portadores da moléstia de Hansen

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    SANTOS Geraldo Gomes dos

    2000-01-01

    Full Text Available Considerando a moléstia de Hansen um problema de saúde pública, propusemo-nos a examinar a mucosa bucal de doentes hansenianos com o objetivo de detectar possíveis alterações específicas e não-específicas. Examinamos 175 pacientes submetidos a poliquimioterapia, sendo 134 (76,57% multibacilares, dos quais 93 (53,13% na forma virchowiana (MHV e 41 (23,43% paucibacilares. Nenhum dos 175 pacientes examinados apresentou lesões específicas, sendo observadas 76 alterações não-específicas em 65 pacientes representadas por 23 tipos diferentes.

  2. The modified extended Hansen method to determine partial solubility parameters of drugs containing a single hydrogen bonding group and their sodium derivatives: benzoic acid/Na and ibuprofen/Na.

    Science.gov (United States)

    Bustamante, P; Pena, M A; Barra, J

    2000-01-20

    Sodium salts are often used in drug formulation but their partial solubility parameters are not available. Sodium alters the physical properties of the drug and the knowledge of these parameters would help to predict adhesion properties that cannot be estimated using the solubility parameters of the parent acid. This work tests the applicability of the modified extended Hansen method to determine partial solubility parameters of sodium salts of acidic drugs containing a single hydrogen bonding group (ibuprofen, sodium ibuprofen, benzoic acid and sodium benzoate). The method uses a regression analysis of the logarithm of the experimental mole fraction solubility of the drug against the partial solubility parameters of the solvents, using models with three and four parameters. The solubility of the drugs was determined in a set of solvents representative of several chemical classes, ranging from low to high solubility parameter values. The best results were obtained with the four parameter model for the acidic drugs and with the three parameter model for the sodium derivatives. The four parameter model includes both a Lewis-acid and a Lewis-base term. Since the Lewis acid properties of the sodium derivatives are blocked by sodium, the three parameter model is recommended for these kind of compounds. Comparison of the parameters obtained shows that sodium greatly changes the polar parameters whereas the dispersion parameter is not much affected. Consequently the total solubility parameters of the salts are larger than for the parent acids in good agreement with the larger hydrophilicity expected from the introduction of sodium. The results indicate that the modified extended Hansen method can be applied to determine the partial solubility parameters of acidic drugs and their sodium salts.

  3. Mycobacterium leprae in the periodontium, saliva and skin smears of leprosy patients = Mycobacterium leprae no periodonto, saliva e raspados intradérmicos de sujeitos com hanseníase

    Directory of Open Access Journals (Sweden)

    Abdalla, Ligia Fernandes

    2010-01-01

    Full Text Available Objetivo: verificar através da baciloscopia e da reação em cadeia da polimerase (PCR a presença do M. leprae no periodonto, saliva e raspados intradérmicos de pacientes com hanseníase. Metodologia: Realizou-se um estudo transversal do tipo detecção de casos numa instituição referência de hanseníase no Amazonas. Resultados: Foram avaliados 48 pacientes, sendo 15 multibacilares (MB e 33 paucibacilares (PB. Os pacientes MB tiveram o diagnóstico confirmado pela baciloscopia e PCR dos raspados intradérmicos, enquanto que 16 (48,5% dos PB foram positivos apenas na PCR. Quatro pacientes PB negativos na PCR de raspados intradérmicos foram positivos no periodonto e na saliva, 1 positivo na saliva e 2 no periodonto. Nenhuma amostra do periodonto e da saliva foi positiva na baciloscopia. Conclusão: Não houve relação entre a doença periodontal e a presença do M. leprae; a baciloscopia não mostrou ser uma técnica eficiente para análise da saliva e periodonto; a técnica de PCR de raspado dérmico mostrou ser um método mais eficaz no diagnóstico dos PB do que a baciloscopia; a positividade da PCR para detecção do M. leprae nos PB pode ser aumentada coletando raspado intradérmico, periodonto e saliva

  4. EFEKTIFITAS PENCEGAHAN KARIES DENGAN A TRAUMATIC RESTORATIVE TREATMENT DAN TUMPATAN GLASS IONOMER CEMENT DALAM PENGENDALIAN KARIES DI BEBERAPA NEGARA

    Directory of Open Access Journals (Sweden)

    Magdarina Destri Agtini

    2012-12-01

    Full Text Available Worldwide caries is still mainly problem in oral and dental diseases. In developing countries 30%-90% of 12-years old children do not get oral and dental treatment. In Indonesia, several programs have been implemented to improve oral and dental health status for all age groups. How over, a few reports/National dental health profile showed that mean DMF-T tend to increase, year 1970 DMF-T=0,70, 1980 DMF-T= 2,30, 1990 DMF-T=2,70, and National Health Research (Riskesdas 2007 DMFT=4,8. In National Health Research 2007, it was revealed 29,8% of active caries found in 12-years old children. If the active caries are not managed further complication will occure that may cause teeth extraction. An early teeth extraction can influence mastication and general health. Atraumatic Restorative Treatment (ART is a preventive and restorative approach for managing carious lesions ofthe teeth. It constitutes of hand instruments only (no electric drills used for widening cavity openings and for excavating soft decayed tissue from within the cavity, followed by the application of an adhesive dental material, usually a high-viscosity glass-ionomer (GIC filling material, into the cavity and over the adjacent pits and fissures. ART-GIC consepts are minimally invasive, inhibit further progression ofdental caries., preventive, as well as curative. Effectiveness of ART-GIC can be determined by successrate of ART-GIC fillings (F and effect of ART-GIC on both Decayed (D and Performance Treatment Index (PTI. Several studies showed that success rate ART-GIC are varies, around 71%-85%. There is no significant difference of success rate ART-GIC between dentis and dental nurses. The highest rate of Fluor release occurred on the first day after ART-GIC filling. Further more ART-GIC also inhibit new caries, as well as inhibit increased DMF-T. The increasing of F, may influence improvement of PTI (PTI around 50%-52%. Additional can improve dental health services. It is suggested that implementation of ART-GIC is needed in outreach areas with limited facilities; in all primary schools,all health services, under-5 years children, geriatric groups (Panti Wreda. As an alternative way to conduct ART-GIC development through dental nurses. More over suggested, although it is a simple method, a careful implementation of ART-GIC are need to be concern. Thus sustainability of continuing ART-GIC education and training is needed. Key words: Atraumatic Restorative Treatment (ART, Glass lonomer Cement (GiC, Efektifitas ART dan GIC

  5. Perbandingan Jumlah Koloni Bakteri Saliva pada Anak-Anak Karies dan Non Karies Setelah Mengkonsumsi Minuman Berkarbonasi

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    Rendra Chriestedy Prasetya

    2013-07-01

    Full Text Available Dental caries and periodontal disease are well established and common in Indonesia, and both of these diseases are major concerns for the oral and dental health. The objective of this study was to compare the differences in children with and without caries in terms of colony bacteria in the saliva, and the changes before and after consumption of carbonated drink. The study was conducted on Al-Qodiri elementary school students who were 10-12 years old. Saliva was collected before and after consumption (for 2 min of a carbonated drink. T-test was used to analyze the results. The results of the study showed that there was a significant difference (p<0.05 between the caries and non-caries groups.DOI: 10.14693/jdi.v15i1.86

  6. Avaliação das capacitações de hanseníase: opinião de médicos e enfermeiros das equipes de saúde da família Evaluación de las capacitaciones de Hanseníasis: la visión de médicos y enfermeros de los equipos de salud de la familia Evaluation of training programs in Hansen's Disease: opinion of physicians and nurses of family health teams

    Directory of Open Access Journals (Sweden)

    Cléa Maria da Costa Moreno

    2008-11-01

    Full Text Available A hanseníase é uma doença milenar, infectocontagiosa, causada pelo Mycobacterium leprae; manifesta-se em células cutâneas e nervos periféricos. Na década de 1990, as ações de controle foram descentralizadas, passando do estado para o município. Um estado do nordeste brasileiro elaborou, então, uma série de treinamentos em hanseníase para capacitar os profissionais da rede básica. O objetivo deste estudo foi avaliar esses treinamentos a partir da opinião de médicos e enfermeiros das equipes de saúde da família. Os resultados indicam que os profissionais avaliaram os treinamentos positivamente quanto à sua implementação e ao objetivo de capacitá-los para a detecção da doença. Conclui-se que os treinamentos precisam ser continuados e lançam-se algumas reflexões para os próximos.La Lepra es una enfermedad milenaria, infectocontagiosa, provocada por el Mycobacterium leprae; se manifiesta en células cutáneas y nervios periféricos. En la década del 1990, las acciones de control fueron descentralizadas, pasando de la provincia para el municipio. Una provincia del nordeste brasileño elaboró, entonces, una serie de entrenamientos en hanseniasis para capacitar a los profesionales de la red básica. El objetivo de este estudio fue evaluar esos entrenamientos, a partir de la opinión de médicos y enfermeros de los equipos de salud de la familia. Los resultados indican que los profesionales evaluaron los entrenamientos positivamente en cuanto a su implementación y el objetivo de capacitarlos para la detección de la enfermedad. Se concluye que los entrenamientos necesitan ser continuados y se lanzan algunas reflexiones para los próximos.Hansen's Disease is a contagious, milenar disease caused by the Mycobacterium leprae that manifests itself in the cutaneal cells and the peripheral nerves. In the decade of 1990, the control for the disease was descentralized from the state to the municipality level. A northeastern state in

  7. A relação entre soroprevalência de anticorpos contra o glicolipídeo fenólico-I entre crianças em idade escolar e endemicidade da hanseníase no Brasil The relation between seroprevalence of antibodies against phenolic glycolipid-I among school children and leprosy endemicity in Brazil

    Directory of Open Access Journals (Sweden)

    Samira Bührer-Sékula

    2008-01-01

    Full Text Available Os programas de controle da hanseníase se beneficiariam de um método fácil para estimar prevalência e avaliar o impacto das ações de controle na prevalência da doença. A determinação da soroprevalência de anticorpos contra PGL-I através de estudos com crianças em idade escolar foi sugerida como indicador útil da taxa de prevalência da hanseníase a nível municipal.Para investigar se a soropositividade estaria associada aos coeficientes de detecção da hanseníase e se poderia ser usada como indicador da prevalência em outras áreas, 7.073 crianças em três estados endêmicos de hanseníase no Brasil foram testadas. Resultados mostram uma considerável variação da distribuição de soropositividade nas comunidades, independente do número de casos de hanseníase detectados. A soroprevalência foi significativamente menor nos colégios. Nenhuma diferença na distribuição da soropositividade determinada por ELISA ou dipstick foi observada. Nenhuma correlação entre o coeficiente de detecção da hanseníase e soropositividade pôde ser estabelecida.Leprosy control programs would benefit expressively from an easy method to estimate disease prevalence and to assess the effect of leprosy control measures on disease prevalence. Determination of the seroprevalence of antibodies to PGL-I through school children surveys might be a useful indicator of leprosy prevalence at the district level. To investigate whether seropositivity rates could be related to leprosy detection rates and whether seropositivity could be used as a proximal indicator to predict the leprosy incidence in other areas, 7,073 school children in three different leprosy-endemic states in Brazil were tested. The results show a widely varying distribution of seropositivity in the communities independent of the number of leprosy cases detected. Seroprevalence was significantly lower at private schools. No differences in the patterns of seropositivity between ELISA

  8. Qualidade de vida relacionada à saúde avaliada pelo Inventário Pediátrico de Qualidade de Vida 4.0 em pacientes pediátricos com hanseníase e manifestações musculoesqueléticas

    Directory of Open Access Journals (Sweden)

    Luciana Neder

    2015-10-01

    Full Text Available RESUMOObjetivo:Avaliar a qualidade de vida relacionada à saúde (QVRS em pacientes pediátricos com hanseníase.Métodos:Estudo transversal com 47 pacientes com hanseníase e 45 indivíduos saudáveis. A QVRS foi mensurada pelo Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0 e os domínios físico, emocional, social e escolar foram avaliados. Os pacientes com hanseníase foram classificados pelos critérios de Ridley e Jopling e avaliados de acordo com manifestações clínicas musculoesqueléticas, laboratoriais e exames radiográficos.Resultados:A média de idade atual foi similar em pacientes com hanseníase e controles [12(6-18 vs. 15(5-18 anos, p = 0,384], assim como frequências do sexo feminino (p = 0,835 e classes socioeconômicas brasileiras média/baixa (p = 1,0. De acordo com a autoavaliação da criança relacionada com as atividades escolares, esse domínio foi significativamente menor nos pacientes com hanseníase em relação aos controles de 13-18 anos [75(45-100 vs. 90(45-100, p = 0,021]. Os outros domínios foram semelhantes em ambos os grupos (p > 0,05. Pelo menos uma manifestação musculoesquelética (artralgia, artrite e/ou mialgia foi observada em 15% dos pacientes com hanseníase e nenhuma nos controles (p = 0,012. Uma comparação mais detalhada entre pacientes com hanseníase mostrou que a mediana do domínio de capacidade física [81,25(50-100 vs. 98,44(50-100, p = 0,036] e de atividades escolares pela autoavaliação da criança [60(50-85 vs. 80(45-100, p = 0,042] era significantemente menor nos pacientes com manifestações musculoesqueléticas em comparação com a dos pacientes sem essas manifestações. (1 Nenhuma diferença foi evidenciada entre os outros parâmetros de QVRS em ambos os grupos relatados pelos pacientes e pais (p > 0,05.Conclusões:Diminuições dos domínios capacidade física e escolar foram observadas em pacientes com hanseníase pediátrica e manifestações musculoesqueléticas.

  9. Epidemiological Profile of Leprosy in the Brazilian state of Piauí between 2003 and 2008 Perfil epidemiológico da hanseníase no estado do Piauí, período de 2003 a 2008

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    Manoel Wilkley Gomes de Sousa

    2012-06-01

    Full Text Available BACKGROUND: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It is considered a major public health issue in developing countries. OBJECTIVES: To evaluate the clinical and epidemiological profile of leprosy patients between 2003 and 2008 in the state of Piauí, to analyze detection and prevalence rates in the general population and in the population of children under 15 years of age, and to evaluate the predominant clinical forms. METHODS: Data were obtained from the notifiable diseases database of the State Health Department, Piauí, Brazil. Medical records are retrieved from patients' charts using a specific questionnaire and the collected data is then entered into the database system. RESULTS: Of the 12,238 cases of leprosy reported in this period, 85% represented new cases. The mean overall annual detection rate was 54 cases/100,000 habitants. The rate for children under 15 years of age was 15.3 cases/100,000 habitants. Overall, 52.18% of the patients were male; 64.66% were between 20 and 59 years of age; and 53.53% had the paucibacillary form of leprosy. Nevertheless, in 88.82% of cases of the paucibacillary form of the disease, more than five lesions were present, while in 10.55% of cases of the multibacillary form of the disease, no lesions were present. Over 20% of patients had some degree of disability. CONCLUSION: These indicators point to a high circulation of bacilli in the community and highlight the extreme difficulty experienced by the primary healthcare network in organizing itself in order to ensure that patients with this complex disease receive an accurate and early diagnosis.FUNDAMENTOS: A hanseníase é uma doença infecciosa crônica, causada pelo Mycobacterium leprae, sendo considerada um grande problema de saúde pública nos países em desenvolvimento. OBJETIVOS: Objetivou-se estudar o perfil clinicoepidemiológico dos pacientes com hanseníase no período de 2003 a 2008, no estado do Piau

  10. Avaliação da dor em portadores de hanseníase submetidos à mobilização neural Pain in leprosy patients undergoing neural mobilisation treatment

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    Larissa Sales Téles Véras

    2011-03-01

    Full Text Available Este estudo tem como objetivo avaliar o efeito da técnica de mobilização neural sobre a percepção da dor em portadores de hanseníase. A amostra de 56 indivíduos portadores de hanseníase foi randomizada em: grupo experimental (GMN composto por 29 indivíduos submetidos ao tratamento com mobilização neural e grupo controle (GC composto por 27 indivíduos que foram submetidos ao tratamento convencional. A percepção da dor foi avaliada através da Escala Visual Analógica, indicando-se em uma extremidade a marcação de ausência de dor e na outra, pior dor imaginável. O GMN foi submetido ao tratamento utilizando a técnica de mobilização neural, que consistiu de dezoito atendimentos (seis semanas, três vezes por semana. O GC foi submetido ao tratamento convencional com exercícios de flexibilidade, fortalecimento, com uso de exercitadores de tornozelo ou de recursos eletroterápicos. O GMN apresentou redução significativa (p=0,000 na percepção da dor ao comparar o pré e o pós-teste e na comparação com o GC no pós-teste. O GC não apresentou diferença significativa (p=0,520. Conclui-se que a utilização da técnica de mobilização neural promoveu redução nos níveis de dor em portadores de hanseníase.This Study aimed to evaluate the effect of the neural mobilisation technique on pain in patients with leprosy. A sample of 56 individuals with leprosy was randomised into an experimental group (GMN, composed of 29 individuals undergoing treatment with neural mobilisation, and the control group (CG of 27 individuals who underwent conventional treatment. We evaluated the perception of pain by Visual Analogue Scale - EVA. The GMN underwent treatment using the neural mobilisation technique, which consisted of eighteen treatments (six weeks, at three times per week. The CG was subjected to conventional treatment. The GMN showed a significant reduction (p = 0.000 in pain perception when comparing the pre and post-test for the

  11. Fatores de risco para transmissão da Hanseníase Factores de riesgo para la transmisión de la Lepra Risk factors for Leprosy transmission

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    Andréia Soprani dos Santos

    2008-11-01

    Full Text Available Estudo caso controle que objetivou identificar fatores individuais de risco relacionados à transmissão da doença. O grupo caso, composto por 90 pacientes de hanseníase notificados no SINAN entre 2003 e 2006; o grupo controle, constituído por 270 indivíduos sadios, pareados por sexo e faixa etária. Houve associação significativa entre a ocorrência da doença e a presença atual (OR= 2,9 e antiga (OR=5,0 de hanseníase entre parentes co-sangüíneos. Sabendo-se que o exame único dos contatos, no ato do diagnóstico, detecta uma parcela mínima dos casos, propõe-se a realização de exames periódicos dos contatos de hansenianos a fim de detectar os novos casos.Estudio caso controle que objetivó identificar factores individuales del riesgo relacionados a transmisión de la enfermedad. El grupo caso, compuesto por 90 pacientes con lepra notificados en el SINAN entre 2003 y 2006; y el grupo controle, constituido por 270 individuos saludables, pareados por sexo y edad. Hubo asociación significativa entre la ocurrencia de la enfermedad y la presencia actual (OR= 2,9 y antigua (OR=5,0 de la lepra entre parientes co-sanguíneos. Sabiéndose que el examen único de los contactos en el acto del diagnóstico detecta una parcela mínima de los casos, se propone a la realización del examen periódico de los contactos de leprosos a fin de detectar los nuevos casos.This case-control study aimed to identify individual risk factors regarding the transmission of leprosy. The group case represented by 90 cases of leprosy sick people pontificated at SINAN during 2003 and 2006 and a group control constituted by 270 healthy people, paired by gender and age. There was significant statistical between occurrence of the disease and its current presence (OR: 2,9 and old cases (OR= 5,0 of leprosy among co-sanguine relatives. Knowing that the only exam of the contact in the act of the diagnostic detects a minimum part of the new cases, it is proposed to

  12. Estudo comparativo preliminar entre os alongamentos proprioceptivo e estático passivo em pacientes com seqüelas de hanseníase Preliminary comparative study between proprioceptive and passive static stretching in patients with leprosy sequelae

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    Augusto Floricel Diaz

    2008-12-01

    Full Text Available A proposta deste estudo foi comparar a aplicação de alongamento estático passivo e alongamento proprioceptivo no tratamento de seqüelas de hanseníase. Doze pacientes com essas seqüelas participaram da pesquisa, separados aleatoriamente em dois grupos: o grupo FNP, tratado com facilitação neuromuscular proprioceptiva, e o grupo AEP, com alongamento estático passivo. Ambos realizaram dez sessões de alongamentos, sendo submetidos à avaliação inicial e final nas quais foram aplicados o questionário SF-36, mensuradas a amplitude de movimento (ADM do punho e tornozelo, testados os reflexos e a sensibilidade. No grupo FNP foi observada melhora na ADM do tornozelo e em três domínios do SF-36; no grupo AEP, em cinco domínios do SF-36. Quando comparados os grupos, o FNP obteve melhora significativa na extensão do punho, dorsiflexão e plantiflexão em relação ao AEP. A facilitação neuromuscular proprioceptiva parece ser um método mais eficaz para ganhar alongamento muscular e ADM de tornozelo e punho em pacientes com seqüelas de hanseníase. Não foi observada relação entre acréscimo na ADM e melhora na qualidade de vida relacionada à saúde nos pacientes dos dois grupos.The purpose of this study was to compare the effects of two kinds of stretching - passive, static stretching, and proprioceptive neuromuscular facilitation (PNF - in patients with leprosy sequel. Twelve patients were randomly assigned into two groups: the PNF group and the SS group, that was submitted to static stretching. Both groups attended ten stretching sessions, being submitted to initial and final evaluations in which were assessed: health-related quality of life, by means of he SF-36 questionnaire; ankle and wrist range of motion (ROM; and sensitivity and reflex testing. Improvements in ankle movement and in three SF-36 domains were observed in PNF group; and in five SF-36 domains in SS group. PNF group showed better improvement in wrist extension and

  13. Hanseníase no município de Fortaleza, CE, Brasil: aspectos epidemiológicos e operacionais em menores de 15 anos (1995-2006 La Lepra en el municipio de Fortaleza, CE, Brasil: aspectos epidemiológicos y operacionales en menores de 15 años (1995-2006 Hansen's Disease in the municipality of Fortaleza, CE, Brazil: epidemiological and operational aspects in children under 15-years-old (1995-2006

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    Carlos Henrique Morais de Alencar

    2008-11-01

    Full Text Available Estudo transversal que objetiva analisar a ocorrência de casos de hanseníase em menores de 15 anos de idade residentes no Município de Fortaleza e notificados no SINAN. Os indicadores epidemiológicos nesta população mostram hiperendemicidade. Operacionalmente observa-se a manutenção da concentração de atendimento em algumas unidades de referência, apesar de alguns avanços. Diagnóstico tardio, elevado grau de incapacidade no diagnóstico e baixo grau de avaliação de contatos registrados revelam a fragilidade das ações de controle. Ressalta-se a possibilidade de erro diagnóstico frente às características da infecção nesta população. A ocorrência de casos de hanseníase nesta população representa um indicador epidemiológico de grande relevância e sua análise amplia a discussão sobre problemas operacionais na rede de serviços de saúde.Estudio transversal con el objetivo de analizar las ocurrencias de los casos de lepra en menores de 15 años de edad sitiados en la ciudad de Fortaleza y enterados en el SINAN. Los indicadores epidémicos en ésta población se presentaron hiperendémicos. En la operacinalización, se observa el mantenimiento de la concentración de atención en algunas unidades recomendables, a pesar de algunos avances. Diagnósticos muy tardes, gran grado de incapacidad en el diagnóstico y bajo grado de evaluación de contactos registrados, muestran la fragilidad de las acciones de control. Se resalta así la posibilidad de error de diagnóstico delante de las características de la infección en ésta población. La ocurrencia de casos de lepra en ésta población representa un indicador epidémico de gran importancia y su análisis amplia la discusión sobre los problemas operacionales en la red de servicios públicos.This is a sectional study that aims to analyze the occurrence of Hansen's disease cases in 15 year-old minors in the Municipality of Fortaleza and notified in SINAN. The

  14. Detection of Mycobacterium leprae DNA for 36kDa protein in urine from leprosy patients: a preliminary report Detecção do DNA do Mycobacterium leprae para proteína 36 kDa na urina de pacientes com hanseníase: relato preliminar

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    Om Parkash

    2004-10-01

    Full Text Available We have searched for Mycobacterium leprae DNA for 36kDa protein in urine using a M. leprae specific PCR technique. A limited number of 16 patients (of which 11 belonged to lepromatous leprosy and five to tuberculoid leprosy and eight healthy individuals were included for the present study. The number of urine samples positive by PCR were 36.4% (4/11 in lepromatous patients and 40% (2/5 in tuberculoid patients. None of the samples from healthy individuals was positive. To our knowledge, the results indicate, for the first time, the presence of M. leprae DNA in urine from leprosy patients. Another important finding obtained out of the study is that amongst treated patients 66.6% (4/6 were positive whereas amongst untreated only 20% (2/10 were positive. From the present indicative data it appears that treatment improves the PCR results with urine as a sample. Thus, the approach could prove to be useful for monitoring the treatment response of individual patients and needs to be further evaluated with a large number of patients.Pesquisamos o DNA do Mycobacterium leprae para proteína 36 kDa na urina usando a técnica do PCR específica para M. leprae. Um número limitado de 16 pacientes (dos quais 11 tinham hanseníase multibacilar e cinco hanseníase paucibacilar e oito indivíduos saudáveis foram incluídos neste estudo. O número de amostras de urina positivas pelo PCR foi de 36,4% (4/11 em pacientes com hanseníase multibacilar e 40% (2/5 em pacientes com hanseníase paucibacilar. Nenhuma das amostras de indivíduos saudáveis foi positiva. Até onde chega o nosso conhecimento, os resultados indicam, pela primeira vez, a presença de DNA do M. leprae na urina de pacientes com hanseníase. Outro fato importante obtido através do exame é que entre os pacientes tratados 66.6% (4/6 eram positivos enquanto entre os não tratados somente 20% (2/10 foram positivos. Pelos presentes dados indicativos parece que o tratamento melhora os resultados do

  15. Efeitos adversos da poliquimioterapia em pacientes com hanseníase: um levantamento de cinco anos em um Centro de Saúde da Universidade Federal de Uberlândia Adverse effects of multidrug therapy in leprosy patients: a five-year survey at a Health Center of the Federal University of Uberlândia

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    Isabela Maria Bernades Goulart

    2002-10-01

    Full Text Available A implementação da poliquimioterapia (PQT/OMS - composta pelas drogas dapsona, clofazimina e rifampicina - possibilitou a cura da hanseníase, porém não foram priorizados o manejo dos efeitos adversos pelas equipes de saúde. Objetivando determinar a magnitude dos efeitos adversos da poliquimioterapia para hanseníase e relacioná-los como possível causa de não adesividade do paciente ao tratamento, revisou-se prontuários de 187 pacientes tratados com PQT, de 1995 a 2000, no Centro de Saúde Escola (CSE -UFU, com registro de efeitos colaterais em 71 pacientes (37,9%. Dentre os 113 efeitos adversos, 80 (70,7% relacionaram-se à dapsona, 7 (6,2% à rifampicina, 26 (20,5% à clofazimina. Esses efeitos levaram à mudança de esquema terapêutico em 28 (14,9% dos 187 pacientes ou 39,4% dos 71 com efeitos adversos. Discute-se a importância de considerar os efeitos adversos da PQT na capacitação das equipes de saúde para maior adesão do paciente ao tratamento, colaborando para eliminar a hanseníase como problema de saúde pública.The introduction of multidrug therapy (WHO/MDT - composed by the drugs dapsone, clofazimine and rifampicin has enabled the cure of Hansen's disease, however, the adverse effects of these drugs were not given priority by the health team. Aiming to determine MDT's adverse effects' magnitude and relate them to the non-adhesion of patients to the treatment, a study of 187 charts of patients treated with MDT from January of 1995 to May 2000, was carried out at a Health Center of the Federal University of Uberlândia. Side effects were recorded in 71 patients' charts. Among the 113 side effects found, 80 (70.7% were related to dapsone, 7 (6.2% were caused by rifampicin and 26 (20.5% were attributed to clofazimine. These effects induced 28 (14.9%, patients to change the therapeutic scheme, representing 39.4% from the 71 patients with adverse effects. Throughout this study, the importance is discussed of considering MDT

  16. O “drama” da hanseníase: Governador Valadares, as políticas públicas de saúde e suas implicações territoriais na década de 1980

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    Patrícia Falco Genovez

    Full Text Available Resumo A incidência da hanseníase em Governador Valadares nos anos 1980 propiciou à cidade tornar-se uma das pioneiras na introdução da poliquimioterapia. O objetivo aqui é compreender as relações entre os diversos “atores” inseridos nesse contexto, especialmente os funcionários da Fundação Serviço Especial de Saúde Pública e os pacientes. Para a identificação dos territórios que essas relações necessariamente constituíam, foram utilizados diversos instrumentos teóricos, como o “dramatismo” (Burke e a performance (Turner. Buscou-se, com a metáfora teatral, uma dinâmica na qual os diversos atores não só se apresentassem, mas também estabelecessem as suas relações mais significativas, num processo dinâmico de constituições e reconstituições de territórios.

  17. Autoanticorpos em pacientes com hanseníase, com e sem comprometimento articular, no Estado do Amazonas Autoantibodies in leprosy patients, with and without joint involvement, in the state of Amazonas

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    S.L.E Ribeiro

    2009-10-01

    Full Text Available OBJETIVOS: Determinar a frequência do fator reumatoide (FR-IgM, anticorpos antipeptídeos citrulinados cíclicos (anti-CCP, antinucleares (AAN, anticitoplasma de neutrófilos (ANCA, anticardiolipina (aCL e anti-β2 glicoproteína I (anti-β2GPI em pacientes com hanseníase, com e sem comprometimento articular, avaliando a possível associação entre estes autoanticorpos e as manifestações articulares, a forma clínica, a reação hansênica, o tratamento com poliquimioterapia (PQT e a alta. PACIENTES E MÉTODOS: 158 pacientes com hanseníase foram distribuídos em dois grupos; 73 pacientes com (Grupo I e 82 sem comprometimento articular (Grupo II. Compuseram o Grupo III 129 indivíduos saudáveis. MÉTODOS: aglutinação com partículas de látex para FR-IgM, imunofluorescência indireta para AAN e ANCA, e, ELISA para anti-CCP, aCL e anti-β2GPI. RESULTADOS: Dentre 158 pacientes com hanseníase, 56 apresentavam a forma virchowiana (VV. A frequência de anticorpos anti-CCP, FR e AAN nos Grupos I e II foi semelhante à do Grupo III. ANCA não foi detectado em nenhum dos grupos. Anticorpos aCL foram mais frequentes nos pacientes com hanseníase (Grupos I e II que em controles sadios (15,8% vs. 3,1%; P OBJECTIVE: Determine the frequency of rheumatoid factor (IgM-RF and anti-cyclic citrullinated peptide antibodies (anti-CCP, antinuclear antibodies (ANA, antineutrophil cytoplasmic antibodies (ANCA, anticardiolipin antibodies (aCL, and anti-β2 glycoprotein I antibodies (anti-β2GPI in leprosy patients, with and without joint involvement, and to evaluate the possible association among those antibodies and articular manifestations, clinical type, reactional episodes, polychemotherapic treatment (PCT, and discharge from PCT. PATIENTS AND METHODS: One hundred and fifty-eight leprosy patients were divided in two groups of 73 patients (Group I and 82 patients (Group II. Group III was composed of 129 healthy individuals. Methods: Semi-quantitative latex

  18. Hanseníase em menores de quinze anos no município de Paracatu, MG (1994 a 2001 Leprosy in patients under fifteen years of age in the city of Paracatu-MG (1994 to 2001

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    Isaias Nery Ferreira

    2005-03-01

    Full Text Available O Município de Paracatu-MG é considerado prioritário para ações de controle da hanseníase devido às suas taxas de detecção e prevalência desta nosologia, sobretudo em menores de quinze anos. Nos anos de 1998 e 1999, realizou-se um trabalho de esclarecimento sobre sinais e sintomas da doença para uma população de cerca de oito mil escolares, o que contribuiu para o incremento da taxa de detecção da doença em menores de quinze anos, sendo o município classificado como hiperendêmico entre os anos de 1997 e 2001. Realizou-se também um trabalho de desenho descritivo de quarenta e cinco pacientes diagnosticados e tratados no município de Paracatu entre 1994 e 2001. Cinqüenta e três por cento dos diagnósticos foram em crianças do sexo masculino, 75,5% dos casos se situavam entre dez e catorze anos de idade e a escolaridade da população deste estudo está defasada em relação à idade, sendo que 84% da clientela morava em zona urbana. Todos os inscritos (100% foram casos novos, 56,0% de forma multibacilar, forma clínica Dimorfa, e 44% de formas paucibacilares, como a forma clinica Indeterminada (30,8% e a Tuberculóide (13,2%. Todos foram tratados segundo esquema padrão, com 100% de cura. Vinte e quatro por cento dos doentes apresentaram reações no diagnóstico e durante o tratamento, e 9% apresentaram reações no pós-alta. Vinte e dois por cento dos doentes apresentavam algum grau de incapacidade no diagnóstico e 13% apresentavam algum grau de incapacidade na alta (índice considerado alto. Verificou-se que 62% dos pacientes tinham contatos intradomiciliares portadores de hanseníase, sendo que somente em 15,5% destes contatos foram verificadas as duas cicatrizes da vacina BCG. A hanseníase é um sério problema de saúde pública no município estudado, e o trabalho realizado com escolares foi fundamental para o aumento da detecção dos casos.The city of Paracatu-MG is considered a priority for leprosy control

  19. Hanseníase virchowiana associada ao uso de inibidor do fator de necrose tumoral α: relato de caso Lepromatous leprosy associated with the use of anti-TNF α therapy: case report

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    Daniele S Freitas

    2010-06-01

    Full Text Available A terapia anti-TNFα tem sido amplamente utilizada em diversas artropatias inflamatórias crônicas, em especial artrite reumatoide (AR. No entanto, há preocupações quanto à segurança e ao risco de doenças infecciosas nos pacientes. O objetivo deste artigo é descrever um caso de hanseníase, forma virchowiana, em paciente com AR em uso de terapia anti-TNFα. Dessa forma, a vigilância dos eventos adversos deve ser rigorosa, especialmente no que diz respeito às doenças infecciosas. É recomendada investigação apropriada de lesões cutâneas em paciente recebendo terapia anti-TNFα, visto que o quadro clínico inicial pode ser inespecífico, especialmente em regiões endêmicas como o Brasil.TNF blockers have been used in the treatment of several types of chronic inflammatory arthritis, especially rheumatoid arthritis. However, many doubts regarding the safety and high risk of infectious diseases in these patients remain. The main objective of this report was to present a case of lepromatous leprosy in a rheumatoid arthritis patient using TNF blockers. The development of adverse events should be rigorously observed, especially those related to infectious agents. Thus, appropriate investigation of skin lesions in patients receiving anti-TNFa therapy is recommended, as the initial clinical manifestation may be unusual, particularly in endemic regions in Brazil.

  20. Comparison of the cohesion-adhesion balance approach to colloidal probe atomic force microscopy and the measurement of Hansen partial solubility parameters by inverse gas chromatography for the prediction of dry powder inhalation performance.

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    Jones, Matthew D; Buckton, Graham

    2016-07-25

    The abilities of the cohesive-adhesive balance approach to atomic force microscopy (AFM) and the measurement of Hansen partial solubility parameters by inverse gas chromatography (IGC) to predict the performance of carrier-based dry powder inhaler (DPI) formulations were compared. Five model drugs (beclometasone dipropionate, budesonide, salbutamol sulphate, terbutaline sulphate and triamcinolone acetonide) and three model carriers (erythritol, α-lactose monohydrate and d-mannitol) were chosen, giving fifteen drug-carrier combinations. Comparison of the AFM and IGC interparticulate adhesion data suggested that they did not produce equivalent results. Comparison of the AFM data with the in vitro fine particle delivery of appropriate DPI formulations normalised to account for particle size differences revealed a previously observed pattern for the AFM measurements, with a slightly cohesive AFM CAB ratio being associated with the highest fine particle fraction. However, no consistent relationship between formulation performance and the IGC data was observed. The results as a whole highlight the complexity of the many interacting variables that can affect the behaviour of DPIs and suggest that the prediction of their performance from a single measurement is unlikely to be successful in every case.

  1. Avaliação da Hanseníase: relato de experiência de acadêmicos de enfermagem Evaluación de la Lepra: relato de experiencia de estudiantes de enfermería Leprosy assessment: experience report of nursing students

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    Sandra Valéria Martins Pereira

    2008-11-01

    Full Text Available O Brasil é o segundo no mundo em novos casos de hanseníase. O controle da doença continua sendo uma meta desafiante. Buscou-se descrever o perfil morfológico de lesões cutâneas e outras seqüelas e analisar a conduta adotada no cuidado de feridas de um grupo de pessoas com seqüelas de hanseníase asiladas em uma instituição não governamental. A experiência de ensino-aprendizagem foi longitudinal, fundamentada na Metodologia Científica da Assistência de Enfermagem, envolvendo pessoas com seqüelas de Hanseníase asilados em uma instituição não governamental do estado de Goiás. O perfil morfológico das lesões foi: déficit visual, madarose, desabamento da pirâmide nasal, reabsorção de dedos e artelhos, amputação de membros, mal perfurante plantar e garra ulnar. Detectou-se prejuízo da cicatrização devido à aplicação direta e rotineira de sabões abrasivos e anti-sépticos nas lesões.Brasil es el segundo país en el mundo en nuevos casos de Enfermedad de Hansen (Lepra. La eliminación continúa siendo una meta desafiadora. Buscamos describir el perfil morfológico de lesiones cutáneas y secuelas y analizar la conducta adoptada para cuidado de las heridas de un grupo de personas con secuelas de Enfermedad de Hansen de un asilo no gubernamental. La experiencia de enseñanza-aprendizaje se longitudinal, fundamentado en la Metodología Científica de la Asistencia de Enfermería, incluyendo personas con lesiones y secuelas de lepra, internadas en una institución del Estado de Goiás. Todos los internos presentaban lesiones y secuelas de incapacidad asociadas a la lepra: déficit visual, madarosis; caída de la pirámide nasal, reabsorción total de dedos y dedos de los pies, amputación de ambas piernas, mal perforante plantar y garra ulnar. Jabones abrasivos y antisépticos tóxicos eran aplicados directamente en las lesiones, causando prejuicios a la cicatrización.Brazil is the second in the world in new cases of

  2. Assistência de enfermagem ao portador de Hanseníase: abordagem transcultural Asistencia de enfermería al portador de Lepra: abordaje transcultural Nursing assistance to a Leprosy-infected patient: transcultural approach

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    Fernando José Guedes da Silva Júnior

    2008-11-01

    Full Text Available Trata-se de um estudo de caso, desenvolvido em um Centro de Saúde em Teresina - PI, que abordou a problemática da assistência de enfermagem prestada a uma paciente com Hanseníase Multibacilar, enfocando o cuidado de Enfermagem Transcultural, Diagnósticos e Intervenções de Enfermagem segundo a Taxonomia II da NANDA. Realizou-se a entrevista semi-estruturada e observação participante, que possibilitaram a coleta dos dados, os quais foram tratados baseados nos padrões normativos, valores e prática diárias, modos de cuidado popular e cuidados requeridos no sistema profissional. Neste estudo, constatou-se que o planejamento da assistência de enfermagem visou, principalmente, contribuir para a adesão ao tratamento da doença, diminuindo os riscos potenciais e utilizando a preservação, negociação e re-padronização do sistema profissional. Observou-se também a adesão ao tratamento e a realização de autocuidado voltado para a hanseníase de forma culturalmente satisfatória.Es un estudio de caso, desarrollado en un centro de salud en Teresina-PI, que abordó la problemática de la asistencia de enfermería dada a una paciente con lepra multibacilar, enfocando el cuidado de Enfermería Transcultural, Diagnósticos, e Intervenciones de Enfermería segundo la Taxonomía II de NANDA. Se realizó una entrevista semi-estructurada y observación participante, que posibilitaron la colecta de los datos, los cuales fueron tratados basados em los padrones normativos, valores y prácticas diárias, modos de cuidado popular y cuidados requeridos en el sistema profesional. En este estudio, se constató que el planeamiento de la asistencia de enfermería objetivó, principalmente, contribuir para la adhesión al tratamiento de la enfermidad, disminuyendo los riscos potenciales y utilizando la preservación, negociación y repradonización del sistema profesional. Se observó también la adhesión al tratamiento y la realización del auto cuidado

  3. A mucosa oral na hanseníase: um estudo clínico e histopatológico The oral mucosa in leprosy: a clinical and histopathological study

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    Marilda Aparecida Milanez Morgado de Abreu

    2006-06-01

    Full Text Available INTRODUÇÃO: a anseníase multibacilar pode causar comprometimento da mucosa oral, com ou sem lesões aparentes. Há poucos estudos que tratam deste assunto na era da multidrogaterapia. OBJETIVO: Verificar a freqüência do comprometimento da mucosa oral em pacientes de hanseníase multibacilar. CASUÍSTICA E MÉTODOS: Foi realizado um estudo transversal em vinte pacientes de hanseníase multibacilar, não-tratados, atendidos consecutivamente em Dracena, São Paulo, entre o período de 2000 e 2002. Foi realizado exame clínico completo da mucosa oral. Os pacientes foram submetidos a biópsias na mucosa jugal, na língua e no palato mole, em alteração ou em pontos pré-estabelecidos. Os cortes foram corados pelas técnicas da hematoxilina-eosina e Ziehl-Neelsen. O encontro de granuloma e bacilos álcool-ácido-resistentes ao exame histopatológico determinou o comprometimento específico. RESULTADOS: O estudo envolveu 19 pacientes multibacilares com tempo médio de evolução de 2,5 anos. Ocorreu comprometimento histopatológico específico em apenas um paciente virchowiano, com mucosa oral clinicamente normal, na língua e no palato mole. CONCLUSÕES: 1. Alteração clínica na mucosa oral não implica em comprometimento pela doença, é necessário confirmação histopatológica. 2. Alterações clínicas específicas aparentes são raras. 3. A mucosa oral clinicamente normal pode exibir comprometimento histopatológico específico.INTRODUCTION: Multibacillary leprosy may involve the oral mucosa, with or without apparent lesions. There are few studies that deal with this issue in the era of multidrug therapy. AIM: To assess the frequence of oral mucosa involvement in multibacillary leprosy patients. PATIENTS AND METHODS: A transversal study with twenty non-treated multibacillary leprosy patients. The patients were treated in Dracena, São Paulo, between 2000 and 2002. Clinical examination of the oral mucosa was carried out. All patients were

  4. Maternidade e hanseníase: as vivências de separação devido ao isolamento compulsório Being a mother with leprosy: the experiences of separation due to compulsory isolation

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    Suellen Santos Lima de Almeida

    2012-08-01

    Full Text Available As mulheres portadoras de hanseníase, durante grande parte do século XX, não puderam exercer a maternidade devido à política de isolamento compulsório dos doentes adotada para controlar a doença. Os filhos ao nascerem eram levados para os preventórios e o contato com estes era realizado pelo olhar. Visando compreender a experiência da maternidade no hospital colônia foi realizada pesquisa narrativa com três mães que viveram o período de internação compulsória. Os discursos revelam dois momentos distintos da vivência de maternidade: a separação dos filhos com sua posterior volta para casa e a adoção de crianças para realizar a maternidade. Considera-se que a adoção promoveu o encontro com o sentido da existência que havia sido rompido e possibilitou a experiência de ser-mãe.In the twentieth century, women with leprosy could not carry on their maternity because of the statement of compulsory isolation of patients, adopted to control the disease. Their children were taken at birth to prevention centers and the contact of mothers with their babies was only visual. In order to understand the experience of maternity in the leprosaria it was carried out an investigated narrative research with three mothers who lived through the period of compulsory internment. The speeches reveal two distinct moments in the experience of motherhood: the separation of the children with their subsequent return to home and the adoption of other children to achieve motherhood. It is considered that the adoption has promoted the meeting with the meaning of existence that had been broken and allowed the experience of being a parent.

  5. Estudo de 20 focos familiares de hanseníase no município de Duque de Caxias, Rio de Janeiro Study of 20 families with leprosy cases from Duque de Caxias - Rio de janeiro - Brazil

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    Sandra Maria Barbosa Durães

    2005-12-01

    Full Text Available FUNDAMENTOS: O conhecimento da transmissão da hanseníase ainda apresenta lacunas devido ao longo período de incubação e ao fato de poucas pessoas expostas adoecerem. Além da exposição ao M. leprae, a susceptibilidade genética é um importante fator de risco para o adoecimento. OBJETIVO: Caracterizar a transmissão da hanseníase em focos familiares de área endêmica urbana no segundo distrito de Duque de Caxias, Rio de Janeiro, RJ. MÉTODOS: Estudo de 20 famílias, a partir de 20 casos índices (CI, diagnosticados no segundo distrito de Duque de Caxias que apresentaram mais de um caso de hanseníase (co-prevalência, com intervalo de até 10 anos entre os diagnósticos. Foi realizado inquérito domiciliar com preenchimento de questionário estruturado e exame dermatoneurológico. RESULTADOS: Houve predominância da consangüinidade entre os que adoeceram (69/75. A possibilidade de adoecer entre os consangüíneos foi 2,8 vezes maior do que a verificada entre os não consangüíneos. Apenas três cônjuges foram acometidos entre os seis doentes não consangüíneos contra 14 filhos. Em duas famílias os casos foram restritos a uma única geração, em cinco houve acometimento de três gerações, e em 13, de duas gerações. CONCLUSÃO: Embora existam outros fatores de risco envolvidos na transmissão da doença (ambientais, sociais, epidemiológicos, não abordados neste estudo, a consangüinidade mostra associação estatística positiva e reforça a importância da vigilância do núcleo familiar, intra e extradomiciliar, considerando as diferentes situações de convivência. São apresentados aqui dados preliminares do estudo de 70 famílias. A inclusão de um maior número de famílias e o estudo do polimorfismo genético deverá aproximar os estudiosos da complexidade desse tema.BACKGROUND: The transmission of leprosy has issues not understood due to the long incubation period and the fact that only a few of the exposed subjects

  6. Análise espacial da Hanseníase na microrregião de Almenara, MG, Brasil Análisis espacial de la Lepra en la microregión de Almenara, MG, Brasil Spacial analysis of Leprosy in the microregion of Almenara, MG, Brazil

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    Evaldo Pinheiro Amaral

    2008-11-01

    Full Text Available A hanseníase ainda é considerada um problema de saúde pública no Brasil. O objetivo deste estudo é analisar a situação epidemiológica da hanseníase na microrregião de Almenara/MG segundo sua distribuição espacial e suas relações com as condições socioeconômicas da população. Trata-se de um estudo ecológico. Os resultados colocam a microrregião como uma área hiperendêmica e indicam que os serviços de saúde não estão sendo capazes de detectar todos os casos existentes, contribuindo para manter a cadeia de transmissão da doença. A análise espacial identificou dois clusters, sendo um com coeficientes de detecção acima e outro abaixo do esperado. Acredita-se que os resultados obtidos servirão para balizar a elaboração e implementação de medidas de prevenção e controle da hanseníase na região.En Brasil, la hanseniasis todavía sigue siendo un problema de salud pública. El presente estudio ecológico tiene por objeto analizar la situación epidemiológica de la Hanseniasis en la microregión de Almenara, Estado de Minas Gerais, según su distribución espacial y su relación con las condiciones socioeconómicas de la población. Los resultados sitúan a la microregión en calidad de área híper endémica e indican que como los servicios de salud no logran detectar todos los casos existentes persiste la cadena de transmisión de la enfermedad. El análisis espacial identificó dos clusters: uno con coeficientes de detección por arriba y otro por debajo de lo esperado. Los resultados obtenidos podrán servir de base para elaborar y poner en práctica medidas de prevención y control de la hanseniasis en la región.Hansen's disease is still considered a public health problem in Brazil. The objective of this ecological study is to analyze the epidemiological status of Hansen's disease in the microregion of Almenara, State of Minas Gerais, according to its spatial distribution and its relations with the

  7. Mensuração do ângulo articular do cotovelo no teste de tensão neural em indivíduos com hanseníase Mensuration of elbow joint angle in the application of the neural tension test in individuals with leprosy

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    Débora Scheibe

    2012-06-01

    Full Text Available A hanseníase é uma patologia crônica e granulomatosa, que atinge a pele e o sistema nervoso periférico pela invasão no sistema imune do Mycobacterium leprae. O objetivo deste estudo foi mensurar o ângulo articular do cotovelo com a aplicação do teste de tensão neural do nervo ulnar em pacientes com hanseníase. Na aplicação do teste de tensão neural, foram utilizadas a goniometria e a fotometria para a mensuração do ângulo articular do cotovelo, sendo que para a realização da fotometria foi utilizada uma câmera Samsung de 12.1 Mega pixels, e os dados foram analisados pelo software Corel Draw X5 (Microsoft®. Foram selecionados 44 indivíduos da Fundação Pró-Hansen, com média de idade de 48,13±12,55 anos, divididos em três grupos: G1, G2 e G3. O G1 compreende voluntários com hanseníase e sensibilidade preservada; o G2, aqueles com hanseníase e com perda de sensibilidade; e o G3, o controle. Na goniometria, foi encontrada diferença significativa (pLeprosy is a chronic and granulomatous disease, which affects skin and peripheral nervous system by invasion of Mycobacterium leprae in the immune system. The objective of this study was to evaluate the ulnar neural tension test in leprosy patients. In applying the test of neural tension, it was done goniometry and photometry to measure the angle of the elbow joint, and to perform the photometry we used a Samsung camera, 12.1 Mega pixels, and the data were analyzed using Corel Draw Software X5 (Microsoft®. We selected 44 individuals of Pro-Hansen Foundation, with an average age of 48.13±12.55 years, divided in three groups: G1, G2 and G3. G1 consisted of leprosy volunteers with preserved sensibility; the G2, the ones with leprosy and with no sensibility; and G3 was control group. In goniometry, it was found significant difference (p<0.05 when comparing the G1 and G2 with control of both the right and left limb, but no difference was found when comparing the two leprosy

  8. Aplicação de métodos de estimativa da prevalência de hanseníase no Estado de Mato Grosso Application of estimation methods for the hidden prevalence of leprosy in the State of Mato Grosso

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    Eliane Ignotti

    2004-06-01

    Full Text Available Uma questão desafiadora para a eliminação da hanseníase como problema de saúde pública é o conhecimento da sua real prevalência. Este estudo tem por objetivo comparar os resultados de dois métodos publicados como propostas de estimativa de prevalência oculta de hanseníase, a tendência definida pelo Ministério da Saúde, e a estimativa realizada pela Secretaria de Estado de Saúde de Mato Grosso (SES/MT para a implantação do programa "Tolerância Zero: Mato Grosso sem hanseníase", tendo como parâmetro o número de casos novos detectados em 2001. Fez-se a aplicação dos métodos e da tendência, utilizando-se a série de casos de hanseníase detectados no período de 1996 a 2000 para todos os municípios do Estado. Definiu-se como nível endêmico a média aritmética ajustada aos casos novos detectados no mesmo período. Verificou-se que todas as estimativas mostraram associação positiva maior que 75% com o número de casos detectados em 2001. A maior associação foi verificada entre a meta ou estimativa da SES/MT (r²=0,895, que por outro lado não é observada com a exclusão do nível endêmico. Concluímos que os métodos publicados apenas sugerem a presença de reservatórios de casos em áreas com detecção tardia. Operacionalmente, parece mais adequado basear-se em séries históricas segundo idade, classificação operacional, grau de incapacidade física e número de lesões no momento do diagnóstico para a identificação de áreas de risco e, conseqüentemente, eliminação da hanseníase.One of the challenges to eliminate leprosy as a public health problem is to know its real prevalence. This study compares the results of two published methods which propose to estimate the hidden prevalence of leprosy, the trends defined by the Ministry of Health and the estimate made by the State Secretary of Health of Mato Grosso (SES/MT to implement the program "Tolerância Zero: Mato Grosso sem hanseníase" (Zero Tolerance

  9. Breve história da hanseníase: sua expansão do mundo para as Américas, o Brasil e o Rio Grande do Sul e sua trajetória na saúde pública brasileira Trajectory in the Brazilian Public Health

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    Letícia Maria Eidt

    2004-08-01

    Full Text Available Este trabalho faz uma revisão sobre a história da hanseníase através dos tempos, desde sua provável origem na Antigüidade até a sua vinda para as Américas, o Brasil e o Rio Grande do Sul. Relata, também, a evolução das políticas de saúde pública brasileiras adotadas para o seu controle e descreve algumas atitudes da sociedade para com os doentes de hanseníase no passado. Este retrospecto histórico contribui para o conhecimento da doença, para a detecção de fatores predisponentes do binômio saúde-doença e auxilia na compreensão dos sentimentos dos pacientes com relação a sua doença na atualidade.This work makes a review about the history of the Hansen's disease through the time, since its beginning until its arrival in Americas, in Brazil and in Rio Grande do Sul State. Reports the evolution of the public health policies for its control and describes some attitudes of the society with these patients in the past. This history helps to the knowledge of the disease, to the detection of the predisponent factors of the phenomenon health and disease and to understand the feelings of the patients about their disease in the present days.

  10. Avaliação da expressão de interleucina 1 beta (IL-1β e antagonista do receptor de interleucina 1 (IL-1Ra em pacientes com hanseníase Evaluation of the expression of interleukin 1 beta(IL-1β and interleukin 1 receptor antagonist (IL-1Ra in leprosy patients

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    Rosane Dias Costa

    2008-01-01

    Full Text Available A hanseníase é uma doença infectocontagiosa espectral que acompanha-se por uma série de eventos imunológicos desencadeados pela resposta do hospedeiro frente ao agente etiológico, o Mycobacterium leprae. Evidências sugerem que a indução e manutenção da resposta imune/inflamatória na hanseníase estão vinculadas a interações de múltiplas células e fatores solúveis, particularmente através da ação de citocinas. Nesse estudo, foram mensurados níveis de IL-1β e IL-1Ra de 37 casos novos de hanseníase acompanhados ao longo do tratamento e 30 controles sadios pelo teste ELISA. A coleta de sangue periférico foi realizada em quatro tempos para os casos de hanseníase (pré-tratamento com PQT, 2ª dose, 6ª dose e pós-PQT e em único momento para os controles. Na comparação dos níveis das moléculas de casos no pré-PQT e controles, houve diferença estatisticamente significativa somente para IL-1β. Nossos resultados sugerem a participação dessa citocina no processo imune/inflamatório.Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1β and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT, and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1β. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.

  11. O uso da sorologia como ferramenta adicional no apoio ao diagnóstico de casos difíceis de hanseníase multibacilar: lições de uma unidade de referência The use of serology as an additional tool to support diagnosis of difficult multibacillary leprosy cases: lessons from clinical care

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    Maria Leide W. Oliveira

    2008-01-01

    Full Text Available Sete casos de hanseníase multibacilar (MB e dois casos com suspeição de hanseníase atendidos em situações distintas do atendimento clínico-dermatológico na Universidade Federal do Rio de Janeiro são descritos. Todos apresentaram dificuldades no diagnóstico visto que não tinham sinais e sintomas cardinais da hanseníase. Um teste sorológico utilizado como ferramenta auxiliar foi útil no processo de diagnóstico ou exclusão de cada caso e facilitou as discussões acadêmicas na hora do exame clínico. A sorologia e baciloscopia de linfa são consideradas como os únicos instrumentos rápidos e de baixo custo para a confirmação de casos MB atípicos, e as vantagens e desvantagens de cada exame são discutidas. Ambos os testes complementam o processo diagnóstico e classificação dos casos para fins terapêuticos. A vantagem da baciloscopia está na sua capacidade de confirmação do diagnóstico. As vantagens da sorologia são: (a sua aplicabilidade para uso direto por profissionais de saúde no momento da consulta, visto que os resultados são imediatos, (b a possibilidade da participação dos pacientes no processo, e (c oferece uma oportunidade para melhor ensino da patogênese da hanseníase.Seven multibacillary leprosy and two suspected cases assisted in different situations during clinical care activities at the university in Rio de Janeiro city are described. All cases presented some difficulties for diagnosis, since they evolved with few or no cardinal signs or symptoms of leprosy. A serological test used as an auxiliary tool was helpful in the diagnosis or exclusion procedure of each case, facilitating academic discussions at the time of case examination. Considering serology and bacilloscopy (skin smear as the only rapid and relatively cheap available tests for confirmation of atypical MB leprosy, the advantages and disadvantages of their use were discussed. Both tests support the diagnostic procedure and the

  12. Hanseníase no Município de Buriticupu, Estado do Maranhão: busca ativa de casos na população adulta Leprosy in Buriticupu, State of Maranhão: active search for cases in the adult population

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    Antonio Rafael da Silva

    2010-12-01

    Full Text Available INTRODUÇÃO: O estudo foi desenvolvido com o objetivo de avaliar a situação da hanseníase na população adulta do Município de Buriticupu, MA. MÉTODOS: Foi empregado o método de busca ativa na identificação de casos novos, no período de 2005 a 2007. Baciloscopia de raspado intradérmico foi feita em todos os pacientes com lesões de pele compatíveis com hanseníase, enquanto exame histopatológico foi feito naqueles em que havia dúvidas na definição da forma clínica. RESULTADOS: Participaram do estudo 15.409 indivíduos, tendo o exame clínico definido o diagnóstico de hanseníase em 62 pacientes, o que representa um coeficiente de detecção de 40,23/10.000. A baciloscopia foi positiva em seis pacientes, sendo predominante a forma clínica tuberculóide, em 31 casos, seguida da forma indeterminada em 20, dimorfa em 10 e virchowiana em um. O estudo permitiu, ainda, a identificação de outras doenças da pele, tais como pitiríase versicolor, dermatofitose, escabiose, vitiligo e carcinoma de pele. CONCLUSÕES: O elevado coeficiente de detecção define o município como hiperendêmico para a hanseníase. A busca ativa de casos é um método importante para o controle da doença.INTRODUCTION: This study aimed to analyze the leprosy situation, focusing on the adult population of the town of Buriticupu, State of Maranhão. METHODS: An active search was conducted to identify new cases from 2005 to 2007. All patients with injuries suggestive of leprosy were submitted to cutaneous bacilloscopy and biopsies were performed when defining the clinical presentation was difficulty. RESULTS: 15,409 individuals participated in the study and 62 were diagnosed with leprosy which represents a detection coefficient of 40.23/10,000. Bacilloscopy showed positive results in six patients. The predominant clinical form was tuberculoid, 31 cases, followed by the indeterminate form (20 cases, the dimorphous form (10 cases and the lepromatous form (1

  13. Avaliação por imagem do comprometimento osteoarticular e de nervos periféricos na hanseníase Imaging methods evaluation in osteoarticular and peripheral nerves involvement in leprosy

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    Helena Lúcia Alves Pereira

    2006-06-01

    Full Text Available Na hanseníase, lesões ósseas por invasão direta do bacilo são de baixa incidência, e os achados radiológicos destas lesões são de osteomielite aguda ou crônica similares aos de outras infecções granulomatosas. As lesões ósseas mais comuns são devidas ao trauma e a infecção secundária nos tecidos denervados. Radiograficamente, são observados vários graus de reabsorção das extremidades distais envolvendo mãos e pés, ocasionando perda dos dígitos e osteoartropatia neuropática de pequenas articulações. Os achados radiológicos são semelhantes às outras condições nas quais há déficit sensorial, como esclerodermia, siringomielia e diabetes mellitus. A ultra-sonografia (US e a ressonância magnética (RM podem ser úteis na avaliação do comprometimento dos nervos periféricos auxiliando no diagnóstico das neurites, abscessos e no diagnóstico diferencial das síndromes compressivas.In leprosy, bone lesions due direct invasion of bacilli are low in incidence and these lesions exhibit radiologic findings of acute and chronic osteomyelitis similar to those of other granulomatous infectious agents. The more common bone lesions are those due to injurious effects of trauma and infection imposed upon denervated tissues. Radiographycally are seen various degrees of reabsorption of the extremities involving hands and feet with the loss of digits and disorganizing arthropathies in small joints. The radiologic appearance are similar to other conditions in which there is sensory impairment like scleroderma, syringomielia and diabetes mellitus. The ultrasonography and magnetic resonance imaging (MRI can be helpful in evaluation of the involvement of the peripheral nerves helping in the diagnosis of the neuritis, abscess and differential diagnosis in compressive syndromes.

  14. Near nerve potencial of sural nerve in leprosy Estudo da condução do nervo sural com a técnica de eletrodos justa-nervo em pacientes com moléstia de Hansen

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    Ana Paula M. Arruda

    2004-09-01

    Full Text Available Leprosy neuropathy is characterized by initial involvement of the small nerve fibers, later followed by involvement of the large fibers, when routine nerve conduction studies become abnormal. To increase the diagnostic yield and precocity of these studies, we applied the near nerve technique to the sural nerve of 8 leprosy patients. Contrary to our expectations, the main component of the sural nerve sensory action potential was abnormal in all patients, but the minimum conduction velocity originating from small 3-6 mm fibers was normal or only mildly involved in three patients. Also, although Schwann cells are the first to be involved in leprosy, the results are suggestive of axonal degeneration instead of demyelination. To better understand the neurophysiology and physiology of leprosy and to increase the accuracy and precocity of the diagnosis, it will be necessary to investigate patients in the very early stages of the disease and to correlate these findings with the corresponding nerve pathology.Na hanseníase, as fibras de pequeno calibre são acometidas antes que as fibras mais grossas, ocasião em que o estudo da condução torna-se anormal. Neste estudo, utilizou-se a técnica de registro com eletrodos justa-nervo com a finalidade de aumentar a precocidade e a acurácia diagnóstica, devido à sua capacidade de detectar potenciais oriundos de fibras com cerca de 3-6 mm. Contrário às nossas expectativas, o componente principal do potencial sensitivo do nervo sural foi anormal em todos os pacientes, enquanto a velocidade de condução mínima foi normal ou discretamente alterada em 3 pacientes. Além disso, os resultados são sugestivos de degeneração axonal e não mielinopatia, como seria esperado em uma doença que compromete inicialmente a bainha de mielina. Para um melhor entendimento da fisiologia e fisiopatologia, e para aumentar a precocidade diagnóstica, é fundamental estudar casos bem precoces e correlacionar os dados

  15. Fatores associados ao domicílio e à família na determinação da hanseníase, Rio de Janeiro, Brasil Factors associated with household and family in leprosy transmission in Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Vera Lúcia G. de Andrade

    Full Text Available O objetivo deste estudo foi analisar algumas características dos domicílios e dos chefes de família como possíveis fatores de determinação da hanseníase. Compararam-se unidades domiciliares onde existiam casos de hanseníase com dois grupos de domicílios de não hansenianos. Como grupos de domicílios sem casos de hanseníase, estudaram-se os domicílios vizinhos dos doentes e os domicílios fora dos focos ou áreas sem casos de hanseníase. Todos os domicílios localizam-se no município de São Gonçalo, área endêmica urbana na periferia da região metropolitana do Rio de Janeiro. Em um mapa aerofotogramétrico, contendo a descrição dos 584 setores censitários, marcaram-se todos os 2412 casos diagnosticados residentes. Compararam-se os domicílios com casos de hanseníase, Grupo I, com os seus respectivos vizinhos (Grupo II e com os domicílios fora do foco (Grupo III. Os domicílios do Grupo I foram pareados com os seus respectivos vizinhos (Grupo II e processados pelo método condicional. Para a comparação entre os grupos I e grupo III, usou-se o método incondicional. O Grupo I comparado com o II apresentou associação entre idade e nível de escolaridade do chefe da família. A comparação das características dos chefes de família e dos domicílios com casos de hanseníase em relação aos localizados fora do foco mostrou, como fatores diferenciais, idade, tipo de casa e disponibilidade de pontos de água intradomiciliar. Os autores discutem que os contrastes da área fora do foco são indicativos de um assentamento populacional mais recente e não de fatores associados à hanseníase. Somente na análise pareada dos doentes com seus vizinhos, estando então os fatores ambientais da área de foco controlados, confirmou-se a associação da idade e do grau de escolaridade. Com os determinantes do nível particular próprio do grupo social, interagem, no nível individual, a idade e o grau de escolaridade como fatores que

  16. Atenção básica de saúde e a assistência em Hanseníase em serviços de saúde de um município do Estado de São Paulo La atención básica a la salud y la asistencia a la Lepra en servicios de salud de un municipio del Estado de São Paulo The basic health and assistance to Hansen's Disease in health care services of a municipality of São Paulo State

    Directory of Open Access Journals (Sweden)

    Adriana Jimenez Pereira

    2008-11-01

    Full Text Available Este é um estudo descritivo desenvolvido em um município do Estado de São Paulo. Objetivo: identificar e caracterizar as ações do Programa de Controle da Hanseníase nos serviços de saúde municipais. Metodologia: entrevistas gravadas com gestor municipal de saúde e profissionais da assistência à hanseníase. Resultados: a política pública municipal em saúde prioriza o desenvolvimento da atenção básica com ênfase na saúde pública. As ações são realizadas por profissionais capacitados e experientes em hanseníase. Ve rificou-se a não realização da busca ativa dos casos, necessária para o real conhecimento da situação epidemiológica, e das ações de educação em saúde, importante para a redução do estigma e aproximação do sujeito à nova situação de vida e enfrentamento de limitações.Este estudio descriptivo es una investigación que analizó la situación de la atención de la Lepra en un municipio del Estado de Sao Paulo. Objetivo: identificar y caracterizar las acciones del Programa de Control de Lepra de los servicios de salud de ese municipio. Metodología: se entrevistaron a los profesionales encargados de la atención de lepra y al director municipal de políticas de salud. Resultados: las políticas públicas municipales de salud priorizaron el desarrollo de la atención básica, con énfasis en la salud pública tradicional. Las acciones de control de lepra son realizadas por trabajadores capacitados y con significativa experiencia profesional. Se resalta la ausencia de busca activa de los casos, necesaria para un conocimiento real de la situación epidemiológica y la importancia de educación en salud, para reducir el estigma y aproximar el sujeto a las adaptaciones necesarias en la nueva situación de vida para afrontar las limitaciones.This descriptive study was carried out in a municipality of Sao Paulo State. The objective was to identify and to characterize the Leprosy Control Program in

  17. Estudo da mucosa nasal de contatos de hanseníase, com positividade para o antígeno glicolipídio fenólico 1 Nasal mucosa study of leprosy contacts with positive serology for the phenolic glycolipid 1 antigen

    Directory of Open Access Journals (Sweden)

    Ana Cristina da Costa Martins

    2010-10-01

    Full Text Available A hanseníase é uma doença infecciosa de evolução crônica causada pelo Mycobacterium leprae que acomete com maior frequência a mucosa nasal. Esse acometimento independe da forma clínica da doença e pode ocorrer mesmo antes do aparecimento de lesões na pele ou em outras partes do corpo. Faz-se necessário a vigilância epidemiológica dos contatos de casos novos de hanseníase para o diagnóstico precoce da doença. OBJETIVOS: Identificar lesões específicas e precoces de hanseníase por meio de exame endoscópico, baciloscópico, histopatológico e da reação em cadeia da polimerase em Tempo Real da mucosa das cavidades nasais dos contatos domiciliares e peridomiciliares com sorologia positiva para o antígeno glicolipídio fenólico. MATERIAL E MÉTODOS: Estudo prospectivo transversal em 31 contatos de pacientes de hanseníase com sorologia positiva (PGL-1, 05 controles negativos e 01 positivo no período de 2003 a 2006. RESULTADOS: Entre os contatos soropositivos a PCR-RT foi positiva para a presença de DNA de M. leprae em 06 (19,35% destes e o maior número de cópias do genoma do bacilo foi encontrado no contato que adoeceu. CONCLUSÃO: Isoladamente os exames da mucosa nasal não permitiram o diagnóstico precoce da hanseníase, mas com a combinação de vários métodos, o exame dos contatos pôde ajudar na identificação da infecção subclínica e monitoramento daqueles que poderiam ter papel importante na transmissão da doença.Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The disease more frequently affects the nasal mucosa and can occur independently of its clinical form or even before lesions on the skin or on other parts of the body. It is necessary to employ epidemiological surveillance of household contacts with new leprosy cases for early disease diagnosis. AIM: identify specific and early leprosy lesions through endoscopic, baciloscopy, histopathology exams, and real time polymerase chain

  18. Estudo epidemiológico de 107 focos familiares de hanseníase no município de Duque de Caxias - Rio de Janeiro, Brasil Epidemiologic study of 107 cases of families with leprosy in Duque de Caxias, Rio de Janeiro, Brazil

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    Sandra Maria Barbosa Durães

    2010-06-01

    Full Text Available FUNDAMENTOS - Os pacientes multibacilares (MB são a principal fonte de infecção na hanseníase e esse risco é maior nos contatos domiciliares dos pacientes MB do que nos contatos dos paucibacilares (PB e na população em geral. Entretanto, os contatos domiciliares são os mais próximos do caso-índice (CI, em termos genéticos. OBJETIVO: Analisar dados epidemiológicos das variáveis: sexo, idade, anos de estudo, grau de parentesco com o CI e tipo de contato residencial (intradomiciliar ou peridomiciliar com o CI em 107 famílias de hanseníase. MÉTODOS: Foram realizadas visitas domiciliares para exame clínico dos familiares. Os prontuários dos CIs e de seus coprevalentes (contatos familiares que também tiveram hanseníase foram revistos. RESULTADOS: A análise controlada das variáveis tipo de contato e grau de parentesco revelou que o contato domiciliar e o parentesco de primeiro grau estão independentemente associados a uma probabilidade maior de adoecer. CONCLUSÃO: Os contatos domiciliares, em geral, são os mais próximos do caso, em termos genéticos, e aferir a magnitude desses riscos separadamente tem sido um desafio nos estudos de vigilância de contatos em hanseníase. Os resultados deste estudo confirmam os dados da literatura, demonstrando a influência genética no desfecho da hanseníase per se.BACKGROUNDS: ultibacillary patients are the major source of infection in leprosy. Nevertheless, the risk is higher in household contacts between multibacillary patients than paucibacillary patients and in the general population. Household contacts are in close genetic relationship with the index case-patient. OBJECTIVE: To evaluate epidemiological data of the following variables: age, gender, education level, genetic proximity, and type of contact with the index case-patient (household or not in 107 families with leprosy. METHODS: Home visits were conducted to clinically examine family members. The medical charts of index case

  19. Unilateral demodicidosis of face mimicking Hansens disease

    National Research Council Canada - National Science Library

    Vashisht, Deepak; Singh, Jatinder; Baveja, Sukriti; Tiwari, Rohit; Bhatnagar, Anuj

    2016-01-01

    .... We report a case of facial Demodicosis which presented like atypical rosacea with a gradually progressing swelling and redness on right side of face which was initially diagnosed as a case of Hansen’s disease...

  20. [Migration and Hansen's disease in Mato Grosso].

    Science.gov (United States)

    Magalhães, Maria da Conceição Cavalcanti; dos Santos, Emerson Soares; de Queiroz, Maria de Lourdes; de Lima, Messias Lucas; Borges, Rita Christina Martins; Souza, Maria Silva; Ramos, Alberto Novaes

    2011-09-01

    Studies on medical geography about leprosy discuss the role of the detailed report of the occupation of the territories as a basis of the permanence of leprosy focus. In Brazil, the states that present the highest rates of detection historically are in the Amazon region, which shows an uneven regional evolution of the disease. This paper analyzes the evolution of leprosy contextualizing the migratory processes that occurred in the State of Mato Grosso since the second half of the 20th century. The economic dynamism that occurred in the State in the 1970s, 1980s and 1990s caused population growth rates higher than the national average. The data analyzed permitted an association between the evolution of leprosy and the process of occupation of the mato-grossense territory. However, the permanence of leprosy in the municipalities of the Baixada Cuiabana, as well as in other municipalities that lost population, seem to point to the existence of geographic contexts of different vulnerability to the social production of the disease in the tate. The migration would explain the appearance and evolution of leprosy. However, we consider that the maintenance of the endemic can be associated to contextual factors related to environment.