WorldWideScience

Sample records for karen evans edmond

  1. Karen voices on resettlement

    Directory of Open Access Journals (Sweden)

    The Karen Women’s Organisation

    2008-04-01

    Full Text Available With little support and often under threat, members of theKaren Women’s Organisation have conducted research,provided programmes and support, and challenged thewisdom of international NGOs and UNHCR.

  2. a Few Lines about Karen

    Science.gov (United States)

    Smorodinskaya, Noemi

    2013-06-01

    Karen had tons of amazing students, and it's unfortunate that they could not contribute to this collection. They would have a lot of marvelous stories to tell, since they spent so many days and nights at Karen's house, enjoying Bella Artemievna'sREFID="9789814436571_0023FN001"> hospitality and kindness. Karen was a difficult person, with many eccentricities, but at the same time he was very kind and forgiving. When people he knew had troubles, he always did whatever he could to help them. I should add, however, that due to the many tragedies he had experienced in his family life, Karen's threshold for what counted as troubles was unusually high, and what others perceived as major problems struck him as the minor complications of everyday life...

  3. 100 maja Veneetsias / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2010-01-01

    Eesti väljapanekust "100 maja / houses" (komissar Ülar Mark, kuraator Karen Jagodin, autorid Kalle Vellevoog, Tiiu Truus, Martin Pedanik, Karen Jagodin) 12. Venezia arhitektuuribiennaalil "Inimesed kohtuvad arhitektuuris" (üldkuraator Kazuyo Sejima). Lisaks 21. sajandi eramutele on ekspositsioonis valik märgilise tähendusega eramuid Eesti Vabariigi ajast aastatel 1918-1940 ja nõukogude ajajärgust

  4. 100 maja Veneetsias / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2010-01-01

    Eesti väljapanekust "100 maja / houses" (komissar Ülar Mark, kuraator Karen Jagodin, autorid Kalle Vellevoog, Tiiu Truus, Martin Pedanik, Karen Jagodin) 12. Venezia arhitektuuribiennaalil "Inimesed kohtuvad arhitektuuris" (üldkuraator Kazuyo Sejima). Lisaks 21. sajandi eramutele on ekspositsioonis valik märgilise tähendusega eramuid Eesti Vabariigi ajast aastatel 1918-1940 ja nõukogude ajajärgust

  5. Independent identification of meteor showers in EDMOND database

    CERN Document Server

    Rudawska, R; Tóth, J; Kornoš, L

    2014-01-01

    Cooperation and data sharing among national networks and International Meteor Organization Video Meteor Database (IMO VMDB) resulted in European viDeo MeteOr Network Database (EDMOND). The current version of the database (EDMOND 5.0) contains 144 751 orbits collected from 2001 to 2014. In our survey we used EDMOND database in order to identify existing and new meteor showers in the database. In the first step of the survey, using Dsh criterion we found groups around each meteor within similarity threshold. Mean parameters of the groups were calculated and compared using a new function based on geocentric parameters (solar longitude, right ascension, declination, and geocentric velocity). Similar groups were merged into final clusters (representing meteor showers), and compared with IAU Meteor Data Center list of meteor showers. This paper presents the results obtained by the proposed methodology.

  6. Obituary: Edmond M. Reeves, 1934-2008

    Science.gov (United States)

    Noyes, Robert; Parkinson, William

    2009-01-01

    With great sadness we report that Edmond (Ed) M. Reeves, a former leader of solar space research projects at Harvard College Observatory [HCO] and the Harvard-Smithsonian Center for Astrophysics [CfA], died on 8 August 2008, in Arlington, Virginia, after a long and heroic struggle with cancer. Ed was born in London, Ontario, Canada, on 14 January 1934. During his undergraduate and graduate years at the University of Western Ontario [UWO], he was in the Royal Canadian Navy (Reserve) as a Cadet (1952-1956), then as Instructing Officer, HMCS Prevost (1956-1959), and Lieutenant, Royal Canadian Navy (Reserve) retired. He received a Ph.D. in 1959 from the UWO, specializing in atomic and molecular physics. After two years of postdoctoral research in ultraviolet atomic spectroscopy at the Department of Physics, Imperial College, London, England, Ed joined the HCO Solar Satellite project, working with Leo Goldberg, Director of HCO, and pioneer in solar spectroscopy. In 1968, Ed was appointed Senior Research Associate at HCO, and in 1973 he received a joint appointment as Physicist at the Smithsonian Astrophysical Observatory [SAO] when the CfA was initiated under George Field. During his seventeen years at the Observatory, Ed led a large and vibrant group of engineers and scientists in the Solar Satellite Project, developing a series of space missions to explore the extreme ultraviolet emission from the Sun. Ed also maintained his interest and research in laboratory atomic and molecular astrophysics and enjoyed a vigorous involvement in the HCO Shock Tube Laboratory. In the early 1960s, in the area of molecular spectroscopy, Ed and Bill Parkinson photographed the vacuum ultraviolet absorption spectrum of CO (the Fourth Positive system), which was produced at high temperature in a shock tube. This laboratory spectrum shortly led to the discovery of CO as an important source of opacity in the solar ultraviolet. Goldberg, who first identified CO vibration-rotation bands in the

  7. Rejoinder to Karen Lutfey Spencer

    NARCIS (Netherlands)

    Wild, V.; Drewniak, D.P.; Sauer, C.G.; Krones, T.

    2017-01-01

    Refers to: Karen Lutfey Spencer, What is the future of research on medical decision making? (And is it bright?): A response to Drewniak and colleagues, Social Science & Medicine, Volume 168, November 2016, Pages 175-177. http://dx.doi.org/10.1016/j.socscimed.2016.09.017

  8. Talking about Books: Karen Hesse.

    Science.gov (United States)

    Beck, Cathy; Gwyn, Linda; Koblitz, Dick; O'Connor, Anne; Pierce, Kathryn Mitchell; Wolf, Susan

    1999-01-01

    Presents an interview with Karen Hesse, author of 12 books of fiction for young, middle, and older readers, and winner of the 1998 Newbery Award. Offers an overview of Hesse's books, organized into picture books, transition chapter books, and novels. Presents a discussion of the themes found in her books, highlighting children's discussion…

  9. Karen Hesse: The Rest Is History

    Science.gov (United States)

    Pierpont, Katherine

    2004-01-01

    This article presents a profile of Newbery Award-winning author Karen Hesse, who is best known for her knack for recovering the little-known stories of the past and making them resonate once again in her books. As a meticulous researcher and lover of things from the past, some of Karen Hesse's most well-loved stories have tugged at her sleeve (and…

  10. Obituary: David Stanley Evans, 1916-2004

    Science.gov (United States)

    Bash, Frank N.

    2005-12-01

    distances. This relation between angular diameters and a V-R color index is called the Barnes-Evans Relation. Tom Barnes gives most of the credit to Evans, but said that David insisted that the authors be listed in alphabetical order. This work was greeted with initial skepticism but it stimulated an enormous amount of interest and has been used to measure distances to 100 Cepheid variable stars in our galaxy. The method gives a distance to one of them, Delta Cephei, that agrees closely with recently measured parallaxes using HST. The Barnes-Evans method yields distances which are accurate to a few percent and is applicable to Cepheids in nearby galaxies. Before coming to Texas, David Evans had never given a large lecture course at a university, and his efforts met with mixed success especially in introductory classes for freshmen facing a "science requirement." David had considerably more success supervising PhD dissertations. He was supervisor for four. He was promoted to the position of Jack S. Josey Centennial Professor of Astronomy in 1984, which is the position he held until his retirement in 1986. He was awarded the Gill Medal of the Astronomical Society of South Africa in 1988. David Evans had a remarkable facility for language, especially English. He was an author of eight books including a 1966 edition of "Teach Yourself Astronomy", which was an introduction to astronomy and an inspiration to a number of currently active astronomers. He also loved history, especially of Southern Hemisphere astronomy but also of the McDonald Observatory. In fact, David continued to be very active after retirement and when he died he had completed a book (with Karen Winget) on the eclipse expedition to Mauritania, which is not yet printed.

  11. Lyn Evans decelerates!

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    After more than 40 years at CERN, 15 of which were dedicated to ensuring that the LHC comes to completion, Lyn Evans is retiring. The Imperial College Professor and recently-elected Fellow of the British Royal Society has set himself new challenges, but plans to keep strong links with CERN. His big thank you goes to the many hundreds of people who built one of the most complex scientific instruments ever conceived by mankind. Note from the Editor: It is unusual for the Bulletin to adopt a question-and-answer style. However, we recognise that, with someone of Lyn’s stature, the appropriate thing to do is simply to give him the floor. Bulletin: Lyn, are you really leaving CERN? I am retiring but I will not completely lose contacts with CERN and the LHC. It’s time to slow down for me now but I will join the CMS Collaboration. I will help with the link between the experiment and the machine. Bulletin: After many years as LHC Project Manager...

  12. [Dr. Edmond Locard (1877-1966), the Sherlock Holmes of Lyons].

    Science.gov (United States)

    Maze, Michel; Stagnara, Denise; Fischer, Louis-Paul

    2007-01-01

    Doctor Edmond Locard (1877-1966), a French forensic scientist, a disciple of famous Professor Alexandre Lacassagne, created in Lyons, in 1910, the first French laboratory of technical police. During more than fourty years, he used and developed new scientific techniques (fingerprint identification, study of marks and dust...) in order to help the policemen and judges to solve the most horrible crimes.

  13. Karen Blixen i øst og vest

    DEFF Research Database (Denmark)

    Heede, Dag

    2014-01-01

    Anmeldelser af Ivo Holmqvist (red.): Den främmande förförerskan. Svenska synpunkter på Karen Blixen og Marianne T. Stecher: The Creative Dialectic in Karen Blixen’s Essays. On Gender, Nazi Germany, and Colonial Desire......Anmeldelser af Ivo Holmqvist (red.): Den främmande förförerskan. Svenska synpunkter på Karen Blixen og Marianne T. Stecher: The Creative Dialectic in Karen Blixen’s Essays. On Gender, Nazi Germany, and Colonial Desire...

  14. 基于Edmonds-Karp算法的输入排队调度%Input-queued Crossbar Scheduling Based on Edmonds-Karp Algorithm

    Institute of Scientific and Technical Information of China (English)

    法拉

    2005-01-01

    输入排队Crossbar调度算法是以获得交换机的输入端口和输出端口最大匹配,从而得到高吞吐量为目的.因而在调度算法理论研究中把应用了二部图最大匹配的Maximum Size Matching和 Maximum Weight Matching算法作为目前各种调度算法性能评价标准.Edmonds-Karp算法是图论中求解网络最大流的经典算法之一.该文介绍了如何使用Edmonds-Karp算法求解二部图的最大匹配问题,并且应用算法于输入排队调度算法仿真中,得出经典MSM和MWM算法的性能仿真曲线,为进一步研究调度算法打下了理论基础.

  15. Evans Syndrome: A case report

    Directory of Open Access Journals (Sweden)

    F. Porcaro

    2014-08-01

    Full Text Available We describe a case of a 14-years old caucasian female affected by autoimmune hemolytic anemia and thrombocytopenia successfully treated with intravenous immunoglobulin and steroids. Nevertheless, neutropenia occurred during follow-up period. Positivity of direct antiglobulin test and sieric anti-neutrophil antibodies suggested the diagnosis of Evans syndrome trilineage.

  16. Keystone characteristics that support cultural resilience in Karen refugee parents

    Science.gov (United States)

    Harper, Susan G.

    2015-08-01

    This participatory action research study used the conceptual framework of social-ecological resilience to explore how Karen (pronounced Ka·rén) refugee parents re-construct cultural resilience in resettlement. The funds of knowledge approach helped to define essential knowledge used by Karen parents within their own community. Framing this study around the concept of resilience situated it within an emancipatory paradigm: refugee parents were actors choosing their own cultural identity and making decisions about what cultural knowledge was important for the science education of their children. Sustainability science with its capacity to absorb indigenous knowledge as legitimate scientific knowledge offered a critical platform for reconciling Karen knowledge with scientific knowledge for science education. Photovoice, participant observation, and semi-structured interviews were used to create visual and written narrative portraits of Karen parents. Narrative analysis revealed that Karen parents had constructed a counter-narrative in Burma and Thailand that enabled them to resist assimilation into the dominant ethnic culture; by contrast, their narrative of life in resettlement in the U.S. focused on the potential for self-determination. Keystone characteristics that contributed to cultural resilience were identified to be the community garden and education as a gateway to a transformed future. Anchored in a cultural tradition of farming, these Karen parents gained perspective and comfort in continuity and the potential of self-determination rooted in the land. Therefore, a cross-cultural learning community for Karen elementary school students that incorporates the Karen language and Karen self-sustaining knowledge of horticulture would be an appropriate venue for building a climate of reciprocity for science learning.

  17. Keystone characteristics that support cultural resilience in Karen refugee parents

    Science.gov (United States)

    Harper, Susan G.

    2016-12-01

    This participatory action research study used the conceptual framework of social-ecological resilience to explore how Karen (pronounced Ka·rén) refugee parents re-construct cultural resilience in resettlement. The funds of knowledge approach helped to define essential knowledge used by Karen parents within their own community. Framing this study around the concept of resilience situated it within an emancipatory paradigm: refugee parents were actors choosing their own cultural identity and making decisions about what cultural knowledge was important for the science education of their children. Sustainability science with its capacity to absorb indigenous knowledge as legitimate scientific knowledge offered a critical platform for reconciling Karen knowledge with scientific knowledge for science education. Photovoice, participant observation, and semi-structured interviews were used to create visual and written narrative portraits of Karen parents. Narrative analysis revealed that Karen parents had constructed a counter-narrative in Burma and Thailand that enabled them to resist assimilation into the dominant ethnic culture; by contrast, their narrative of life in resettlement in the U.S. focused on the potential for self-determination. Keystone characteristics that contributed to cultural resilience were identified to be the community garden and education as a gateway to a transformed future. Anchored in a cultural tradition of farming, these Karen parents gained perspective and comfort in continuity and the potential of self-determination rooted in the land. Therefore, a cross-cultural learning community for Karen elementary school students that incorporates the Karen language and Karen self-sustaining knowledge of horticulture would be an appropriate venue for building a climate of reciprocity for science learning.

  18. Macromolecules and Enzymes: The Geneva Heritage from Kurt H. Meyer and Edmond H. Fischer.

    Science.gov (United States)

    Fischer, Edmond H; Piguet, Alfred

    2009-12-01

    On the 26th May 2009, Edmond Fischer, winner with Ed Krebs of the Nobel prize in physiology or medicine in 1992, and his colleague at the time of his research activities at the Ecole de chimie of the University of Geneva, Alfred Piguet, met with Andreas Hauser, Claude Piguet and Howard Riezman of the Section de chimie et biochimie of the University of Geneva to talk about how they became scientists under the impetus of Kurt H. Meyer and what became of them thereafter.

  19. Size fractionation of trace metals in the Edmond hydrothermal plume, Central Indian Ocean

    Science.gov (United States)

    Sands, C. M.; Connelly, D. P.; Statham, P. J.; German, C. R.

    2012-02-01

    The investigation of the distribution of trace elements between the dissolved, colloidal and particulate phases within a hydrothermal plume is key to understanding plume processes. Particulate and colloidal size fractions of four trace elements (iron, manganese, copper and phosphorus) along with the dissolved size fraction of iron, manganese and copper have been determined in the hydrothermal plume overlying the Edmond vent-site in the Central Indian Ocean. Dissolved iron and manganese are the most heavily enriched metals in hydrothermal fluids emerging from vents and iron plays a significant role in subsequent dissolved-particulate interactions within hydrothermal plumes. Copper and phosphorus are each representative members of discrete groups of tracers (chalcophile elements and oxyanions, respectively) that are known to exhibit distinct patterns of behaviour, relative to iron, within hydrothermal plumes. Here we show that iron is present in all three hydrothermal plume fractions (dissolved, colloidal and particulate), being least abundant in dissolved form. Manganese resides predominantly in the dissolved fraction, copper resides primarily in the particulate phase and phosphorus is abundant in both the colloidal and coarser particulate phases, but not the dissolved fraction. The correlation of phosphorus to iron in the Edmond hydrothermal plume is both (i) constant across the colloidal and coarser particulate phases and (ii) matches well to broader inter-ocean trends reported previously from the Atlantic and Pacific Oceans. These results demonstrate a mechanism whereby plume-height P:Fe ratios are established during the very earliest stages of dissolved Fe(II) oxidation, followed by aggregation into coarser hydrothermal plume particles. This provides a strong argument for the study of P:Fe ratios in hydrothermal sediments as potential paleotracers of deep-water dissolved phosphate distributions and, hence, past deep-ocean circulation patterns.

  20. Trace Element Distributions and Size Fractionation in the Edmond Hydrothermal Plume, Central Indian Ridge

    Science.gov (United States)

    Sands, C. M.; Connelly, D. P.; Green, D.; German, C. R.; Statham, P. J.; Gallant, R.; von Damm, K.

    2004-12-01

    Because cycling of the entire ocean volume through hydrothermal plumes is rapid relative to thermohaline circulation (order 103 years), understanding the processes active within these plumes is crucial if we are to assess their impact on global geochemical cycles. Preliminary results from hydrothermal plume particle analyses at the Kairei and Edmond systems (Indian Ocean) have indicated that key processes, previously identified to be important in the Atlantic Ocean, also appear broadly applicable to the Indian Ocean. This was not immediately expected because parallel work has shown that the rate of dissolved iron (II) oxidation in hydrothermal plumes decreases systematically from the Atlantic to the Indian and Pacific Oceans. Here, we examine dissolved-particulate trace metal distributions in greater detail within one Indian Ocean plume (Edmond), together with the complementary vent-fluid data, to investigate these processes further. Upon oxidation, dissolved iron (II) initially forms colloidal iron (III) which then aggregates to form particulate iron (III) - the oxyhydroxide particles which apparently co-precipitate and adsorb dissolved metals from the surrounding seawater. What has remained unstudied, however, is the role that colloidal rather than aggregated particulate Fe may play in these systems. To investigate this we have combined studies of large-volume plume-particle samples (1.0μ m filters) with a series of dissolved, colloidal and finer-grained particles collected using a CTD-rosette. Here, we will discuss the distributions of Fe and the relative fractionations of Mn, Cu (representative of the chalcophile elements) and P (representative of the oxyanions) within and between different hydrothermal "pools": dissolved, colloidal, fine particles and coarse particles as determined from filtration through 0.1, 0.4 and 1.0μ m filters.

  1. November 2011 DMM Podcast: an interview with Karen Steel

    Science.gov (United States)

    2011-01-01

    SUMMARY Excerpts from an interview with Karen Steel, of the Wellcome Trust Sanger Institute, in which she explains how she got hooked on studying deafness in mouse mutants and discusses the importance of mouse genetics for advancing biomedical research. Narrated by Sarah E. Allan. To listen to this podcast, visit http://www.biologists.com/DMM/podcasts/index.html.

  2. Plain and Integral: An Interview with Karen Kho

    Directory of Open Access Journals (Sweden)

    Jonathan Reams

    2006-06-01

    Full Text Available Karen Kho describes her work in the Alameda County Green Building Program. She covers the application of an integral framework to working with a variety of stakeholders in the residential building industry. This work includes a stakeholder analysis, rating program, educational materials and guidelines. How the program expanded beyond Alameda County is also covered.

  3. Karen Gehrt named associate director of Virginia Cooperative Extension

    OpenAIRE

    Sutphin, Michael D.

    2006-01-01

    Karen Gehrt of Champaign, Ill., has been named the associate director of Family and Consumer Sciences programs for Virginia Cooperative Extension. In her new position at Virginia Tech, Gehrt will serve as a state program leader for the development and delivery of educational programs that meet the needs of Virginia's families and communities.

  4. Karen Hesse: From Grade School Writer to Newbery Medalist.

    Science.gov (United States)

    Brodie, Carolyn S.

    2001-01-01

    Discusses author Karen Hesse's books for children and young adults; suggests ideas for related activities that include appropriate Web sites; and presents an annotated bibliography for books for young readers, books for older readers, audio, video, Web biographical information, print biographical information, and additional sources. (LRW)

  5. Evans Functions, Jost Functions, and Fredholm Determinants

    Science.gov (United States)

    Gesztesy, Fritz; Latushkin, Yuri; Makarov, Konstantin A.

    2007-12-01

    The principal results of this paper consist of an intrinsic definition of the Evans function in terms of newly introduced generalized matrix-valued Jost solutions for general first-order matrix-valued differential equations on the real line, and a proof of the fact that the Evans function, a finite-dimensional determinant by construction, coincides with a modified Fredholm determinant associated with a Birman-Schwinger-type integral operator up to an explicitly computable nonvanishing factor.

  6. 76 FR 7589 - Bob Evans Farms, Inc., an Ohio Corporation, a Subsidiary of Bob Evans Farms, Inc., a Delaware...

    Science.gov (United States)

    2011-02-10

    ... Employment and Training Administration Bob Evans Farms, Inc., an Ohio Corporation, a Subsidiary of Bob Evans... Assistance (TAA), applicable to workers and former workers of Bob Evans Farms, Inc., an Ohio Corporation, a subsidiary of Bob Evans Farms, Inc., a Delaware Corporation, Galva, Illinois. The negative determination...

  7. Modern Aspects of Halophilism: The Edmond de Rothschild School in Molecular Biophysics (12th) Held in Israel on March 26-April 5, 1989. Program and Abstracts

    Science.gov (United States)

    1989-04-01

    Cellulare, UniversitA di Roma, Roma, Italy ’Centro de Biologia Molecular , CSIC -UAM, Cantoblanco, Madrid 34, Spain The ribosomes of extremely halophilic...JD-A275 842 THE TWELFTH EDMOND DE ROTHSCHILD SCHOOL IN MOLECULAR BIOPHYSICS MODERN ASPECTS DTIC OF 0 ELECTEOFFEB 0 3,1994 HALOPHILISM SFE’, PROGRAM...Copy THE TWELFTH EDMOND DE ROTHSCHILD SCHOOL IN MOLECULAR BIOPHYSICS MODERN ASPECTS I CRAMSDTIC TAB 1 OF HALOPHILISM u .............. PROGRAM Dist

  8. Post-arrival health screening in Karen refugees in Australia.

    Directory of Open Access Journals (Sweden)

    Georgia A Paxton

    Full Text Available OBJECTIVE: To document the prevalence of nutritional deficiencies, infectious diseases and susceptibility to vaccine preventable diseases in Karen refugees in Australia. DESIGN: Retrospective audit of pathology results. SETTING: Community based cohort in Melbourne over the period July 2006-October 2009. PARTICIPANTS: 1136 Karen refugee children and adults, representing almost complete local area settlement and 48% of total Victorian Karen humanitarian intake for the time period. MAIN OUTCOME MEASURES: Prevalence of positive test results for refugee health screening, with breakdown by age group (<6 years, 6-11 years, 12-17 years, 18 years and older. RESULTS: Overall prevalence figures were: anaemia 9.2%, microcytosis 19.1%, iron deficiency 13.1%, low vitamin B(12 1.5%, low folate 1.5%, abnormal thyroid function tests 4.4%, vitamin D<50 nmol/L 33.3%, hypocalcaemia 7.4%, raised alkaline phosphatase 5.2%, abnormal liver transaminases 16.1%, hepatitis B surface antigen positive 9.7%, hepatitis B surface antibody positive 49.5%, isolated hepatitis B core antibody positive 9.0%, hepatitis C positive 1.9%, eosinophilia 14.4%, Schistosoma infection 7%, Strongyloides infection 20.8%, malaria 0.2%, faecal parasites 43.4%. Quantiferon-gold screening was positive in 20.9%. No cases of syphilis or HIV were identified. Serological immunity to vaccine preventable diseases was 87.1% for measles, 95% for mumps and 66.4% for rubella; 56.9% of those tested had seroimmunity to all three. CONCLUSIONS: Karen refugees have high rates of nutritional deficiencies and infectious diseases and may be susceptible to vaccine preventable diseases. These data support the need for post-arrival health screening and accessible, funded catch-up immunisation.

  9. The body in adolescent diaries. The case of Karen Horney.

    Science.gov (United States)

    Seiffge-Krenke, Inge; Kirsch, Hiltrud Susanna

    2002-01-01

    The role of the body and its functions in the psychic life of the individual has occupied a central place in psychoanalytic thinking and writing. Developmentally, the body and the ego as a psychic organization have an integral, mutual relationship which becomes particularly important during adolescence, when the body matures physically while at the same time cognition, self-reflection, and social relations develop. This contribution presents results of the content analyses, focusing on the body, of 40 diaries written by twenty women during their adolescent years, compared with Karen Horney's adolescent diaries. In contrary to these diaries of the other young women, Karen Horney's adolescent diaries lack a focus on the body. Instead, idealized relationships with teachers are frequently mentioned. Only in the last diary, written at the transition to young adulthood, is the body, with a focus on sexual relations, more prominent. This discrepancy between Horney and female age-mates in normative samples is noteworthy. It is discussed here with emphasis on theoretical approaches about the body in adolescence in psychoanalysis, the importance of body and sexuality in Karen Horney's later life, Horney's contributions to female psychoanalysis, and her relationship with her father.

  10. Awards for Lyn Evans and Philippe Lebrun

    CERN Multimedia

    2007-01-01

    Lyn Evans has received the American Physical Society’s Robert R. Wilson Prize, while Philippe Lebrun has been awarded an honorary doctorate by the Wrocław University of Technology in Poland. Lyn Evans in front of an LHC dipole magnet. Philippe Lebrun (centre) with the Dean of the Faculty of mechanical and power engineering of the Wrocław University during the ceremony (courtesy of Laurent Tavian).Numerous honours are going to the LHC and those behind it even before this exceptional machine begins operation. The LHC Project Leader, Lyn Evans, has recently been awarded the "Robert R. Wilson Prize for Achievement in the Physics of Particle Accelerators" by the American Physical Society (APS). According to the citation, the prize was awarded "for a sustained career of technical innovation and leadership in the SPS proton-antiproton collider, culminating in the construction and commissioning of the LHC&am...

  11. [Edmond Sergent (1876-1969) and the Pasteur Institute of Algeria].

    Science.gov (United States)

    de la Tribonnière, X

    2000-01-01

    Edmond Sergent, supported by a distinguished team of colleagues, directed the Pasteur Institute of Algeria for over 60 years, from 1900 to 1963. As a student of Emile Roux, Sergent had received a Pasteurian training. His institute devoted extensive study to malaria. Sergent defined the concept of prevention and extended it to other pathologies. For many years, the Institute persevered in carrying out successful antimalarial campaigns such that Algeria was freed of the disease. In 1916-1917, Sergent and his brother were called upon to organise anti-malarial efforts for the Armée d'Orient. By way of systematic and energetic curative and prophylactic measures, they were able to eradicate the disease. In 1908, the Sergent brothers were the first to discover the role of the louse in the transmission of another disease, relapsing fever. The Pasteur Institute team also discovered the sand fly vector which transmits the parasite causing leishmaniasis. The Sergents found a new form of oculonasal myiasis, called "Thimni". In addition, they led effective campaigns against tuberculosis based on BCG vaccination administered throughout Algeria. The Pasteur Institute of Algeria conducted important research in plant and animal diseases. For example, they detected a trypanosome agent causing dromedary "debab", as well as its vector, the horsefly. They also studied in depth bovine piroplasmosis, which causes widespread and destructive disease, and demonstrated the role of the tick in promoting transmission generally. Their work in botany included the discovery that a Fusarium-type fungus was the causal agent for "baïoudh", the main disease of date palms. They also demonstrated the basic role of the fruit fly in alcoholic grape fermentation.

  12. Saniba nom. nov. para Sabina Evans (Lepidoptera, Hesperiidae, Hesperiinae

    Directory of Open Access Journals (Sweden)

    Mielke Olaf H. H.

    2003-01-01

    Full Text Available Saniba nom. nov. for Sabina Evans, 1955 (Lepidoptera, Hesperiidae, Hesperiinae. Sabina Evans, 1955 is preoccupied by Williams (1851 (Annelida, Polychaeta; a new replacement name is proposed: Saniba Mielke & Casagrande.

  13. Síndrome de Evans en lactantes

    National Research Council Canada - National Science Library

    Olivia Alejandra Flores-Montes; Martha Cecilia Escobar-Orduño; Mónica Lozano-Garcidueñas; Jaime Guadalupe Valle-Leal

    2017-01-01

    ...% y una mortalidad del 10% de este síndrome. Casos clínicos: Se presenta la información clínica y la evolución del síndrome de Evans en dos pacientes lactantes que inicialmente fueron diagnosticados con trombocitopenia inmune primaria...

  14. Entrevue guidée avec Karen Messing

    Directory of Open Access Journals (Sweden)

    Ana-Maria Seifert

    2009-02-01

    Full Text Available Karen Messing nous a accordé une entrevue pour la rubrique des Défricheurs de PISTES de la revue. Dans son cas nous devons plutôt parler d’une défricheuse de pistes. En effet, tout au long de sa vie professionnelle elle s’est intéressée aux particularités reliées à la question du genre dans le travail et plus particulièrement au travail des femmes et à ses conséquences sur leur santé. Elle était professeure à l’Université du Québec à Montréal, elle vient tout juste de prendre sa retraite « officielle ». Elle est détentrice d’un doctorat en biologie et elle s’est graduellement intéressée à la question de l’environnement de travail et à ses effets sur la santé des personnes. Au début des années 90, elle est allée se perfectionner en ergonomie afin de se doter d’outils d’analyse du travail. Ses recherches ont porté sur plusieurs métiers (préposés aux bénéficiaires, préposés au nettoyage, caissières, etc.. Karen Messing a publié plusieurs livres et articles scientifiques sur la question qui sont importants. Nous vous invitons à la connaître un peu mieux.Karen Messing granted us an interview for the magazine’s Défricheurs de PISTES section. In her case, she is a groundbreaker. In fact, throughout her professional life, she has been interested in the specific issues related to the subject of gender in work, and particularly to women’s work and its impacts on their health. She was a professor at the Université du Québec à Montréal, and has just begun her “official” retirement. She has a doctorate in biology and gradually became interested in the subject of the work environment and its effects on people’s health. In the early 1990s, she refined her skills in ergonomics in order to have the necessary work analysis tools. Her research has investigated several professions (orderlies, cleaning workers, cashiers, etc.. Karen Messing has published several important scientific books and

  15. Lessons Learned: Insights into One Teacher’s Experience Working with Karen Refugee Students in the United States

    Directory of Open Access Journals (Sweden)

    Daniel J. Gilhooly

    2015-01-01

    Full Text Available This study is informed by funds of knowledge and culturally responsive teaching studies that aim to explore and legitimize the cultural knowledge immigrant children bring to their communities and schools. Consequently, this paper specifically addresses issues related to the educational experiences of Karen children and their parents from one American teacher/researcher who has worked with the Karen for the past four years. In aggregate, this paper addresses issues germane to Karen education including; (1 background information on Karen educational experiences prior to resettlement, including a review of their journey from Thailand to the U.S.; (2 important characteristics of Karen culture; (3 Karen names; (4 Sgaw Karen language characteristics; (5 the language divide between parents and children; (6 parental involvement in their children’s schooling; (7 American teacher perceptions of Karen students; (8 issues over grading and, finally; (9 gender issues.

  16. Radio Astronomy Data Transfer and eVLBI using KAREN

    CERN Document Server

    Weston, Stuart; Gulyaev, Sergei

    2011-01-01

    Kiwi Advanced Research and Education Network (KAREN) has been used to transfer large volumes of radio astronomical data between the Radio Astronomical Observatory at Warkworth, New Zealand and various international organizations involved in joint projects and VLBI observations. Here we report on the current status of connectivity and on the results of testing different data transfer protocols. We investigate new UDP protocols such as 'tsunami' and UDT and demonstrate that the UDT protocol is more efficient than 'tsunami' and 'ftp'. We also report on the tests on direct data streaming from the radio telescope receiving system to the correlation centre without intermediate buffering or recording (real-time eVLBI).

  17. Assessment of the Psychosocial Development of Children Attending Nursery Schools in Karen Refugee Camps in Thailand

    Science.gov (United States)

    Tanaka, Akiko

    2013-01-01

    The Karen, an ethnic minority group in Burma, have experienced a prolonged state of exile in refugee camps in neighboring Thailand because of ethnic conflict in their home country. Nursery schools in the three largest Karen refugee camps aim to promote the psychosocial development of young children by providing a child-centered, creative,…

  18. Honoring the Complexities of Our Lives: An Interview with Karen Hesse.

    Science.gov (United States)

    Bryant, Ellen Huntington

    1997-01-01

    Presents an interview with award-winning author Karen Hesse, discussing her writing for children and young adults. Discusses how ideas for particular books arose, as well as the research and writing processes that went into them. Appends reviews of nine books by Karen Hesse. (SR)

  19. Assessment of the Psychosocial Development of Children Attending Nursery Schools in Karen Refugee Camps in Thailand

    Science.gov (United States)

    Tanaka, Akiko

    2013-01-01

    The Karen, an ethnic minority group in Burma, have experienced a prolonged state of exile in refugee camps in neighboring Thailand because of ethnic conflict in their home country. Nursery schools in the three largest Karen refugee camps aim to promote the psychosocial development of young children by providing a child-centered, creative,…

  20. A strange case of Evans syndrome

    Directory of Open Access Journals (Sweden)

    Manuel Monti

    2013-12-01

    Full Text Available Evans syndrome is a rare autoimmune disease presenting hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. It can have an extremely serious disease course and, in rare cases, this can even be life-threatening. First-line treatment consists of steroids and/or immunoglobulin. Further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We report a case of Evans syndrome in a 54-year old woman admitted to the Emergency Department (ED for asthenia. Etiopathogenic, clinical, therapeutic and evolutive aspects are discussed. In contrast to many cases described in the literature, our patient had a satisfactory response to corticoids. We also discuss how to make a specific diagnosis, even in a suburban ED with limited resources, in order to admit patients to the appropriate hospital department and allow the correct therapy to be started as early as possible.

  1. Síndrome de Evans en lactantes

    OpenAIRE

    Olivia Alejandra Flores-Montes; Martha Cecilia Escobar-Orduño; Mónica Lozano-Garcidueñas; Jaime Guadalupe Valle-Leal

    2017-01-01

    Introducción: El síndrome de Evans se caracteriza por la disminución de, al menos, dos líneas celulares en ausencia de otros diagnósticos. Anteriormente, se definía como el desarrollo simultáneo o secuencial de trombocitopenia inmune primaria y anemia hemolítica autoinmune sin etiología específica. Se ha reportado una incidencia del 37% y una mortalidad del 10% de este síndrome. Casos clínicos: Se presenta la información clínica y la evolución del síndrome de Evans en dos pacientes lactant...

  2. A strange Evans syndrome: a case report

    OpenAIRE

    Le Scanff, Julie; Durupt, Stéphane; Bailly, François,; Rode, Agnès; Sève, Pascal

    2009-01-01

    Hepatic angiosarcoma is a rare malignant vascular tumor, which accounts for up to 2% of all primary liver tumors. The most frequent symptoms on presentation are weight loss, weakness and abdominal pain. Diagnosis of diffuse hepatic angiosarcoma can be challenging. We report an original case of diffuse liver angiosarcoma revealed by haematological abnormalities initially diagnosed as an Evans syndrome. Anaemia and thrombocytopenia are rarely the first manifestations of this pathology. They are...

  3. Radio Astronomy and eVLBI using KAREN

    CERN Document Server

    Weston, Stuart; Gulyaev, Sergei

    2010-01-01

    Kiwi Advanced Research and Education Network (KAREN) has been used to transfer large volumes of radio astronomical data between the AUT Radio Astronomical Observatory at Warkworth, New Zealand and the international organisations with which we are collaborating and conducting observations. Here we report on the current status of connectivity and on the results of testing different data transfer protocols. We investigate new UDP protocols such as "tsunami" and UDT and demonstrate that the UDT protocol is more efficient than "tsunami" and ftp. We report on our initial steps towards real-time eVLBI and the attempt to directly stream data from the radio telescope receiving system to the correlation centre without intermediate buffering/recording.

  4. Domestication and Mistranslation of Oriental Jewelries and Music in Edmond O’Donovan’s The Merv Oasis

    Directory of Open Access Journals (Sweden)

    Ahmad Gholi

    2017-03-01

    Full Text Available From the perspective of a translation scholar like Susan Bassnett, travel writing is not dissimilar to translation. Like a translator, travel writer translates his traversed culture (i.e., target culture for the consumption of his/her home readership. Similar to textual translation, this cultural translation can be either successful or doomed, contingent on the travel writer cum cultural translator’s translation: does he/she translate on the basis of foreignization or domestication or mistranslate? The current article draws on Bassett’s cultural translation theory as its analytical tool and applies to Edmond O’Donovan’s travelogue, The Merv Oasis to illustrate how this travel writer as a cultural translator in his journey to Oriental locus both domesticates and mistranslate his encountered culture in particular his female travelees’ jewelries as well as their very indigenous music.

  5. Nostalgia Arhitektuurimuuseumis : kuldsed kuuekümnendad / Karen Jagodin ; interv. Ellu Maar

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Näitusest "Kuuekümnendad. Eesti moodne arhitektuur" ja sisearhitektide Väino Tamme ning Vello Asi loomingu näitusest Eesti Arhitektuurimuuseumis. Kuraatorid Karin Hallas-Murula ja Karen Jagodin. Eesti 1960. aastate sisearhitektuurist

  6. Nostalgia Arhitektuurimuuseumis : kuldsed kuuekümnendad / Karen Jagodin ; interv. Ellu Maar

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Näitusest "Kuuekümnendad. Eesti moodne arhitektuur" ja sisearhitektide Väino Tamme ning Vello Asi loomingu näitusest Eesti Arhitektuurimuuseumis. Kuraatorid Karin Hallas-Murula ja Karen Jagodin. Eesti 1960. aastate sisearhitektuurist

  7. Validation of a brief mental health screener for Karen refugees in primary care.

    Science.gov (United States)

    Brink, Darin R; Shannon, Patricia J; Vinson, Gregory A

    2016-02-01

    Karen refugees from Burma are one of the largest refugee groups currently resettling in the USA. Karen people have endured decades of civil war and human rights violations, leaving them more likely to develop serious mental health disorders. There is a noted lack of brief, culturally validated tools present in primary care settings for detecting posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) in Karen refugees. To create the Karen Mental Health Screener, a five-question screening tool used to identify depression and PTSD and to validate it against a clinical reference standard. This validation study was conducted during a primary care visit. Participants completed a 20-item questionnaire using a 4-point visual aid and the PTSD and MDD portions of the Structured Clinical Interview for DSM Disorders (SCID-CV for DSM-IV) as the reference standard. Both the questionnaire and the relevant sections of the SCID-IV were rigorously translated and administered by trained researchers along with a trained Karen interpreter. Logistic regression models and receiver operating characteristic curve analyses were used to determine a subset of items that could be used to construct a screener to identify Karen patients who were most likely to have PTSD and/or MDD. A final five-question screener was created with very strong performance characteristics. With a clinical cut score of 4, these items displayed very strong performance characteristics with sensitivity = 0.96, specificity = 0.97, positive predicted value = 0.83 and negative predicted value = 0.99. The Karen Mental Health Screener is a valid measure for detecting PTSD and major depression in Karen people from refugee backgrounds presenting in a primary care setting. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. Two Versions of Buddhist Karen History of the Late British Colonial Period in Burma:

    Directory of Open Access Journals (Sweden)

    Kazuto Ikeda

    2012-12-01

    Full Text Available The majority of the Karen people in Burma are in fact Buddhist, in spite of their widespread image as Christian, pro-British, anti-Burman, and separatist. In the last decade of British rule, two Buddhist interpretations of Karen history—virtually the first ethnic self-assertion by the Buddhist Karens—were published along with the first Christian version. Writing in Burmese for Burmese readers, the authors of these Buddhist versions sought to prove that the Karen were a legitimate people (lumyo comparable to the Burman and Mon in the Buddhist world, with dynastic lineages of their own kingship (min reaching back into the remote past, and a group faithful to their religious order (thathana. This linkage of ethnicity=kingship=religion was presented in order to persuade skeptical readers who believed that the Karen, lacking the tradition of Buddhist min, were too primitive to constitute an authentic lumyo of the thathana world. Analysis of these texts will shed light on the social formation of Karen identity among the Buddhists from the 1920s to the 1930s. This will also lead us to consider the historical processes whereby the quasi-ethnic idioms and logic innate to the Burmese-speaking world were transformed in the face of modern and Western notions of race and nation, and consequently the mutation of Burma into an ethnically articulated society.

  9. EVANS FUNCTIONS AND ASYMPTOTIC STABILITY OF TRAVELING WAVE SOLUTIONS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper studies the asymptotic stability of traveling wave solutions of nonlinear systems of integral-differential equations. It has been established that linear stability of traveling waves is equivalent to nonlinear stability and some “nice structure” of the spectrum of an associated operator implies the linear stability. By using the method of variation of parameter, the author defines some complex analytic function, called the Evans function. The zeros of the Evans function corresponds to the eigenvalues of the associated linear operator. By calculating the zeros of the Evans function, the asymptotic stability of the travling wave solutions is established.

  10. The Case of Three Karen Refugee Women and Their Children: Literacy Practices in a Family Literacy Context

    Science.gov (United States)

    Quadros, Sabrina; Sarroub, Loukia K.

    2016-01-01

    The lack of research about the Karen, one of 135 ethnic groups from Myanmar limits literacy educators charged with educating this refugee population in public schools. In this case study the authors explore the literacy practices of Karen families when at school and in their homes and within an ESL family literacy program. The case of these…

  11. An assessment of Evans' unified field theory I

    CERN Document Server

    Hehl, F W

    2007-01-01

    Evans developed a classical unified field theory of gravitation and electromagnetism on the background of a spacetime obeying a Riemann-Cartan geometry. This geometry can be characterized by an orthonormal coframe theta and a (metric compatible) Lorentz connection Gamma. These two potentials yield the field strengths torsion T and curvature R. Evans tried to infuse electromagnetic properties into this geometrical framework by putting the coframe theta to be proportional to four extended electromagnetic potentials A; these are assumed to encompass the conventional Maxwellian potential in a suitable limit. The viable Einstein-Cartan(-Sciama-Kibble) theory of gravity was adopted by Evans to describe the gravitational sector of his theory. Including also the results of an accompanying paper by Obukhov and the author, we show that Evans' ansatz for electromagnetism is untenable beyond repair both from a geometrical as well as from a physical point of view. As a consequence, his unified theory is obsolete.

  12. Soul / Randy Becker, Bill Evans, Evelin Samuel ; interv. Sven Sapelson

    Index Scriptorium Estoniae

    Becker, Randy

    2007-01-01

    The Soulbop Bandi rajajad Randy Becker ja Bill Evans ning meie Evelin Samuel gospeli ja rhytmblues'i juurtega soulist. Lk. 72-73 Inessa Josingu ja Ande Kaalepi souliteemaline fotolavastusega ruumikujundus

  13. Soul / Randy Becker, Bill Evans, Evelin Samuel ; interv. Sven Sapelson

    Index Scriptorium Estoniae

    Becker, Randy

    2007-01-01

    The Soulbop Bandi rajajad Randy Becker ja Bill Evans ning meie Evelin Samuel gospeli ja rhytmblues'i juurtega soulist. Lk. 72-73 Inessa Josingu ja Ande Kaalepi souliteemaline fotolavastusega ruumikujundus

  14. Parcels and Land Ownership, Published in 2011, Evans County Government.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Parcels and Land Ownership dataset as of 2011. The extent of these data is generally Evans County, GA. This metadata was auto-generated through the Ramona GIS...

  15. 76 FR 7832 - Evans Solutions, LLC; Notice of Declaration of Intention and Soliciting Comments, Protests, and...

    Science.gov (United States)

    2011-02-11

    ... Energy Regulatory Commission Evans Solutions, LLC; Notice of Declaration of Intention and Soliciting... Intention. b. Docket No: DI10-20-000. c. Date Filed: September 21, 2010. d. Applicant: Evans Solutions, LLC...). h. Applicant Contact: Reginald Evans, Evans Solutions, LLC, P.O. Box 1303, Sumter, SC...

  16. Computerized tomographic study of normal Evans index in adult Nigerians

    Directory of Open Access Journals (Sweden)

    Ahmed Umdagas Hamidu

    2015-01-01

    Full Text Available Background: The evaluation of degree of ventricular enlargement should be based on established indices rather than on personal experience as this is highly subjective. Our aim was to establish normal values for Evans index in a Nigerian adult population as none has been found in the Nigerian medical literature. Materials and Methods: Axial computerized tomographic brain scans of 488 normal subjects were reviewed retrospectively. Of them, 319 (65.36% of the patients were males and 169 (34.63% were females; their ages ranged from 18 to 84 years with a mean age of 37.26 years. The images were acquired using a multi-slice GE Sigma excite scanner. Evans index was measured as the linear ratio of the total width of the frontal horns of the cerebral lateral ventricles to the maximum intracranial diameter. Results: The mean value for Evans index for the studied population was 0.252 ± 0.04. The EI increased with age and it was slightly higher among males. The difference in Evans value in males and females was not statistically significant. Individuals above 60 years old had the highest Evans values in both sexes. Conclusion: This study has established ranges of normal value for Evans index in a Nigerian population. It agrees with the diagnostic cut-off value of > 0.3 for hydrocephalus and it compares well with that of the Caucasians.

  17. Declinations in the Almagest: An Evaluation and Comments on their Use by Tycho Brahe and Edmond Halley

    Science.gov (United States)

    Brandt, John C.; Zimmer, P.; Jones, P. B.

    2011-01-01

    The Almagest (Book VII, Chapter 3: Toomer 1998) gives 54 stellar declinations attributed to Timocharis, Aristyllus, Hipparchus, and Ptolemy (“As found by us”). We evaluate these declinations (δ) by comparing them to precessed modern positions (d) obtained by using U.S. Naval Observatory software. A recent HIPPARCOS catalogue is the source of positions, proper motions, and parallaxes, and radial velocities come from the Yale Bright Star Catalog. The standard deviation (σ) is computed for Δ = δ-d for a plausible range of years for each observer. The minimum standard deviation, σmin , determines the accuracies and epochs of observation assuming that an observer’s observations were taken at approximately the same time. The results are: Timocharis, σmin = 0.135° and = +0.022° at 295 BC: Aristyllus, σmin = 0.089° and = -0.004° at 258 BC; Hipparchus, σmin = 0.113° and = +0.010° at 128 BC; and Ptolemy, σmin = 0.199° and = +0.005° at 115 AD. The precisions (σmin) are remarkable, the mean errors () are small, and the dates are compatible with the historical evidence except for Ptolemy. The Δs for individual observers are approximately Gaussian except Timocharis’s value for Arcturus at 5.6σminwhich appears to be erroneous; our results are based on 53 declinations. The study of Almagest declinations by Maeyama (1984) uses the same approach and input data from the catalogue by Boss (1910). The results of the two studies are close, but with differences. Our values should be an improvement because of improved input data. We comment on the use of Almagest declinations by Tycho Brahe and Edmond Halley.

  18. Engaged Teaching and Learning with Adult Karen Refugees in a Service-Learning Site

    Science.gov (United States)

    Smolen, Lynn Atkinson; Zhang, Wei; Detwiler, Stephen

    2013-01-01

    This article describes a case study of a service-learning project connected to a TESOL (teaching English to speakers of other languages) teacher preparation program. The case study explored the teacher candidates' experiences teaching English to Karen refugees from Myanmar (Burma) in a midwestern city in the United States. The teacher candidates'…

  19. Nations Within. American Indian Scholar Karen Gayton Swisher Envisions Effective Education for All Indian Children.

    Science.gov (United States)

    Sheets, Rosa Hernandez

    1997-01-01

    An interview with American Indian educator Karen Gayton Swisher explores the learning styles of American Indian children and the application of ideas about these learning styles in the programs at Haskell Indian Nations University. Native American children should be taught from a constructivist, rather than a deficit, point of view. (SLD)

  20. Engaged Teaching and Learning with Adult Karen Refugees in a Service-Learning Site

    Science.gov (United States)

    Smolen, Lynn Atkinson; Zhang, Wei; Detwiler, Stephen

    2013-01-01

    This article describes a case study of a service-learning project connected to a TESOL (teaching English to speakers of other languages) teacher preparation program. The case study explored the teacher candidates' experiences teaching English to Karen refugees from Myanmar (Burma) in a midwestern city in the United States. The teacher candidates'…

  1. Doing belonging: Meanings of home and settlement among the Karen Community in Brisbane, Australia

    Directory of Open Access Journals (Sweden)

    Jessica Nancy Bird

    2016-07-01

    Full Text Available The phenomenon of belonging allows diasporic people to negotiate socio-cultural terrains that go beyond singular attachments to “here” or “there”.  This paper interrogates doing belonging amongst members of the Karen refugee community from Burma settling in Brisbane, Australia.  We use data collected over twelve months of ethnographic fieldwork using the methods of participant observation and semi-structured interviews.  This paper presents an interpretation of challenges faced by Karen community members as they grapple with local and transnational complexities of belonging within their own community, whilst also establishing belonging to Australian social environments.  We argue that Karen participants’ lived experiences of settlement challenge bounded notions of belonging, thereby allowing us to extend dominant constructions of settlement and social inclusion and give way to a more nuanced representation of an emerging diasporic community.  We thus reposition a resettled refugee community away from disempowering and exclusionary notions that dominant constructions of belonging and inclusion tend to impose. Keywords: Karen, belonging, settlement, refugee, transnational

  2. Nations Within. American Indian Scholar Karen Gayton Swisher Envisions Effective Education for All Indian Children.

    Science.gov (United States)

    Sheets, Rosa Hernandez

    1997-01-01

    An interview with American Indian educator Karen Gayton Swisher explores the learning styles of American Indian children and the application of ideas about these learning styles in the programs at Haskell Indian Nations University. Native American children should be taught from a constructivist, rather than a deficit, point of view. (SLD)

  3. Consider the Source: Feminism and Point of View in Karen Hesse's "Stowaway" and "Witness."

    Science.gov (United States)

    Glenn, Wendy J.

    2003-01-01

    Notes how Karen Hesse strays from her typical pattern of exploring gender issues to provide a look at patriarchal culture from within, in one case, and from multiple points of view in the other, ultimately strengthening the feminist pulse that beats within her earlier works. Concludes that in "Stowaway" and "Witness," the voice of a boy and the…

  4. Newbery Medal Winner Karen Hesse Brings Billie Jo's Voice "Out of the Dust."

    Science.gov (United States)

    Hendershot, Judy; Peck, Jackie

    1999-01-01

    Describes an interview with children's author Karen Hesse, discussing such things as how she chose writing as a career, her use of figurative language and her skillful crafting of dialog, where her book ideas come from, and her latest projects. (SR)

  5. Pregnancy and Evans´ syndrome: case report

    Directory of Open Access Journals (Sweden)

    Santiago Artucio

    2015-12-01

    Full Text Available Evans´ syndrome is the coexistence of autoimmune thrombocytopenia with autoimmune hemolytic anemia. It is rarely found during the course of a pregnancy. This makes treatment options more difficult, since some therapeutic drugs are teratogenic. The effects of Evans´ syndrome in the fetus and newborn are unknown given the low number of reported cases. We report the case of a patient with preconceptional diagnosis of Evans´ syndrome, who develops a hemolytic crisis during the course of a pregnancy, and diagnosis of intrauterine growth restriction (IUGR, treated at Clínica Ginecotocológica “A” at the Pereira Rossell Hospital Center, in Montevideo, Uruguay. Treatment options and evolution are analyzed, as well as previous reports.

  6. Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology

    DEFF Research Database (Denmark)

    Pors, Niels Ole

    2010-01-01

    Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4......Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4...

  7. Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology

    DEFF Research Database (Denmark)

    Pors, Niels Ole

    2010-01-01

    Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4......Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4...

  8. Pojetí úzkostnosti z pohledu teorie Karen Horneyové

    OpenAIRE

    STRŽÍNKOVÁ, Kateřina

    2013-01-01

    This thesis focuses on the verification of relationship between anxiety and early attachment patterns in a population of young adults. Additionally, it serves as a pilot research for a set of unfinished sentences, which was created by the thesis author, and is based on theoretical constructs Karen Horney and is used to detect neurotic attitudes. In the theoretical part of the thesis, there are several topics specified, such as anguish, anxiety neurosis and views of psychological theories on t...

  9. Communication practices of the Karen in Sheffield: Seeking to navigate their three zones of displacement

    OpenAIRE

    Green, Geff; Lockley, Eleanor

    2012-01-01

    This study investigates communication practices of a newly arrived Karen refugee community in the UK who, as well as establishing themselves in a strange country, seek to keep in touch, campaign politically and maintain identity collectively through communication and contact with their global diaspora. We look at the technologies, motivations and inhibiting factors applying to the communication by adult members of this community and construct the idea of three zones of displacement which help...

  10. Drainage effects on the transient, near-surface hydrologic response of a steep hillslope to rainfall: implications for slope stability, Edmonds, Washington, USA

    Directory of Open Access Journals (Sweden)

    G. Biavati

    2006-01-01

    Full Text Available Shallow landslides on steep (>25° hillsides along Puget Sound have resulted in occasional loss of life and costly damage to property during intense or prolonged rainfall. As part of a larger project to assess landslide hazards in the Seattle area, the U.S. Geological Survey instrumented two coastal bluff sites in 2001 to observe the subsurface hydrologic response to rainfall. The instrumentation at one of these sites, near Edmonds, Washington, consists of two rain gauges, two water-content probes that measure volumetric water content at eight depths between 0.2 and 2.0 m, and two tensiometer nests that measure soil-water suction at six depths ranging from 0.2 to 1.5 m. Measurements from these instruments are used to test one- and two-dimensional numerical models of infiltration and groundwater flow. Capillary-rise tests, performed in the laboratory on soil sample from the Edmonds site, are used to define the soil hydraulic properties for the wetting process. The field observations of water content and suction show an apparent effect of porosity variation with depth on the hydraulic response to rainfall. Using a range of physical properties consistent with our laboratory and field measurements, we perform sensitivity analyses to investigate the effects of variation in physical and hydraulic properties of the soil on rainfall infiltration, pore-pressure response, and, hence, slope stability. For a two-layer-system in which the hydraulic conductivity of the upper layer is at least 10 times greater than the conductivity of the lower layer, and the infiltration rate is greater than the conductivity of the lower layer, a perched water table forms above the layer boundary potentially destabilizing the upper layer of soil. Two-dimensional modeling results indicate that the addition of a simple trench drain to the same two-layer slope has differing effects on the hydraulic response depending on the initial pressure head conditions. For slope

  11. Drainage effects on the transient, near-surface hydrologic response of a steep hillslope to rainfall: implications for slope stability, Edmonds, Washington, USA

    Science.gov (United States)

    Biavati, G.; Godt, J. W.; McKenna, J. P.

    2006-05-01

    Shallow landslides on steep (>25°) hillsides along Puget Sound have resulted in occasional loss of life and costly damage to property during intense or prolonged rainfall. As part of a larger project to assess landslide hazards in the Seattle area, the U.S. Geological Survey instrumented two coastal bluff sites in 2001 to observe the subsurface hydrologic response to rainfall. The instrumentation at one of these sites, near Edmonds, Washington, consists of two rain gauges, two water-content probes that measure volumetric water content at eight depths between 0.2 and 2.0 m, and two tensiometer nests that measure soil-water suction at six depths ranging from 0.2 to 1.5 m. Measurements from these instruments are used to test one- and two-dimensional numerical models of infiltration and groundwater flow. Capillary-rise tests, performed in the laboratory on soil sample from the Edmonds site, are used to define the soil hydraulic properties for the wetting process. The field observations of water content and suction show an apparent effect of porosity variation with depth on the hydraulic response to rainfall. Using a range of physical properties consistent with our laboratory and field measurements, we perform sensitivity analyses to investigate the effects of variation in physical and hydraulic properties of the soil on rainfall infiltration, pore-pressure response, and, hence, slope stability. For a two-layer-system in which the hydraulic conductivity of the upper layer is at least 10 times greater than the conductivity of the lower layer, and the infiltration rate is greater than the conductivity of the lower layer, a perched water table forms above the layer boundary potentially destabilizing the upper layer of soil. Two-dimensional modeling results indicate that the addition of a simple trench drain to the same two-layer slope has differing effects on the hydraulic response depending on the initial pressure head conditions. For slope-parallel flow conditions

  12. Drainage effects on the transient, near-surface hydrologic response of a steep hillslope to rainfall: Implications for slope stability, Edmonds, Washington, USA

    Science.gov (United States)

    Biavati, G.; Godt, J.W.; McKenna, J.P.

    2006-01-01

    Shallow landslides on steep (>25??) hillsides along Puget Sound have resulted in occasional loss of life and costly damage to property during intense or prolonged rainfall. As part of a larger project to assess landslide hazards in the Seattle area, the U.S. Geological Survey instrumented two coastal bluff sites in 2001 to observe the subsurface hydrologic response to rainfall. The instrumentation at one of these sites, near Edmonds, Washington, consists of two rain gauges, two water-content probes that measure volumetric water content at eight depths between 0.2 and 2.0 m, and two tensiometer nests that measure soil-water suction at six depths ranging from 0.2 to 1.5m. Measurements from these instruments are used to test one- and two-dimensional numerical models of infiltration and groundwater flow. Capillary-rise tests, performed in the laboratory on soil sample from the Edmonds site, are used to define the soil hydraulic properties for the wetting process. The field observations of water content and suction show an apparent effect of porosity variation with depth on the hydraulic response to rainfall. Using a range of physical properties consistent with our laboratory and field measurements, we perform sensitivity analyses to investigate the effects of variation in physical and hydraulic properties of the soil on rainfall infiltration, pore-pressure response, and, hence, slope stability. For a two-layer-system in which the hydraulic conductivity of the upper layer is at least 10 times greater than the conductivity of the lower layer, and the infiltration rate is greater than the conductivity of the lower layer, a perched water table forms above the layer boundary potentially destabilizing the upper layer of soil. Two-dimensional modeling results indicate that the addition of a simple trench drain to the same two-layer slope has differing effects on the hydraulic response depending on the initial pressure head conditions. For slope-parallel flow conditions

  13. Robley Evans and what physics can do for medicine.

    Science.gov (United States)

    Adelstein, S J

    2001-06-01

    When asked, in 1936 by J. Howard Means, Chief of Medicine at Massachusetts General Hospital, whether radioiodine could be produced for thyroid studies, Karl T. Compton, President of the Massachusetts Institute of Technology, referred the question to Robley Evans of the physics department. In response, Evans formed a team from the fields of physics and medicine that produced 128I for animal studies and, subsequently on a cyclotron dedicated to medical purposes, 130I for human uptake measurements and the treatment of hyperthyroidism. Much of what we have learned about iodine kinetics and the radioiodine therapy of Graves's disease stems from these early seminal reports. The cooperation between physicists and physicians that made their accomplishments possible stands as a model example for interdisciplinary collaboration.

  14. Closet addiction in fiction: the search for Christiana Evans.

    Science.gov (United States)

    Sibley, Gay

    2007-01-01

    Mary Ann Evans, who would later become the great nineteenth-century novelist George Eliot, takes up in her first three works of fiction a discussion of the use of alcohol in her own culture. However, it is in "Adam Bede" (1859) that a significant portion of the discussion (the alcoholism of one female character in particular) is so deliberately closeted -- so backgrounded -- that the structure of the text becomes a slippery portrait, not only of the extent to which the culturally pervasive alcoholism of women was persistently denied, but of Eliot's own mother's hidden substance abuse. An important minor character in "Adam Bede," identified by more than one biographer as having a kinship to Eliot's mother Christiana Evans, shows all the signs and symptoms of alcoholism, a phenomenon which even the story's narrator appears to be hiding from the reader.

  15. Experience with Evans syndrome in an academic referral center

    Directory of Open Access Journals (Sweden)

    José Carlos Jaime-Pérez

    2015-08-01

    Full Text Available OBJECTIVE: To document the experience of one referral service with patients diagnosed with Evans syndrome, the treatment and response and to briefly review current treatment strategies and results.METHODS: Patients enrolled in this study fulfilled criteria for Evans syndrome. Data were retrieved from the clinical files and electronic databases of the Department of Hematology, Hospital Universitario "Dr. José Eleuterio González". Treatment modalities and response and the use of additional therapies were evaluated. The literature was reviewed in the context of the clinical course of the studied patients.RESULTS: Six patients were diagnosed with Evans syndrome in the study period. Patient 1 was treated with steroids, relapsed twice and was again treated with steroids. Patient 2 treated initially with steroids plus intravenous immunoglobulin was subsequently lost to follow-up. A good response was achieved in Patients 3 and 4, who were treated with steroids plus rituximab; patient 4 also received danazol as a second-line therapy. However both relapsed and subsequently underwent splenectomy at ten and nine months, respectively. One patient, number 5, treated with steroids, danazol and rituximab did not relapse within four years of follow-up and Patient 6, who received steroids plus danazol did not relapse within three years of follow-up.CONCLUSION: Evans syndrome is an uncommon hematologic condition rarely diagnosed and not widely studied. Clinicians must have it in mind when evaluating a patient with a positive direct antiglobulin test, anemia and thrombocytopenia, since prognosis depends on its early recognition and opportune therapy, but even this leads to variable results.

  16. Burma/Myanmar: Challenges of a Ceasefire Accord in Karen State Burma/Myanmar: Herausforderungen eines Waffenstillstandsabkommens im Karen-Staat

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    Paul Core

    2009-10-01

    Full Text Available Burma (Myanmar has seen some of the longest-running insurgencies in the world, which have had a devastating effect on local populations and the country as a whole. While the Karen National Union (KNU, which has fought successive Burmese governments since 1949, is in a critical phase of its life, the KNU/KNLA Peace Council (KPC is experiencing life under a ceasefire accord with the Burmese government, the State Peace and Development Council (SPDC. Major challenges have occurred since the ceasefire and future developments are uncertain. Like all ceasefire groups in the country, the KPC has come under immense pressure to follow the government’s “seven-step road map” to democracy, compete in the 2010 elections, and transform its troops into a border guard force under the control of the Burmese military or face disarmament. This article seeks to provide some insights into a ceasefire group, to analyse the failures and successes of the ceasefire accord, and to outline future challenges to the country. Myanmar (Burma ist bis heute Schauplatz von anhaltenden ethnischen Konflikten, welche einen erheblichen Einfluss auf lokale Bevölkerungen und das ganze Land haben. Während die Karen National Union, die seit dem Jahr 1949 gegen die burmesische Regierung kämpft, sich in einer kritischen Phase befindet, hat das KNU/KNLA Peace Council seinen eigenen Frieden mit der Militärregierung geschlossen. Seit dem Waffenstillstand haben sich erhebliche Herausforderungen aufgetan und zukünftige Entwicklungen sind ungewiss. Wie alle Waffenstillstandsgruppen im Land steht die Gruppe unter dem Druck der Regierung, dem „Sieben-Punkte-Fahrplan zur disziplinierten Demokratie“ zu folgen und damit eine politische Partei zu gründen sowie seine Truppen in eine Grenztruppe unter Kontrolle des burmesischen Militärs zu transformieren. Dieser Artikel gibt einen Einblick in eine Waffenstillstandsgruppe, analysiert die Erfolge sowie Misserfolge des

  17. The meaning and value of traditional occupational practice: a Karen woman's story of weaving in the United States.

    Science.gov (United States)

    Smith, Yda J; Stephenson, Stephanie; Gibson-Satterthwaite, Michelle

    2013-01-01

    This case study sought to understand the meaning of restoring traditional weaving as an occupation among Karen women from Burma who now live in an urban city in the United States and to examine the impact of weaving on their daily lives in terms of identity, empowerment, social support, and opportunities for entrepreneurship. The story of one Karen woman, Paw Law Eh, is described. Her story exemplifies the negative consequences of restricted access to familiar and meaningful daily activities, or "occupations", the relationship between occupation and self-identity, how participation in valued occupations can enhance social networks, and the restorative effects that are possible when engagement in meaningful occupations are maintained or restored. Her story demonstrates that occupational therapists have the skills and opportunity to contribute significantly to the well-being of Karen women by supporting the restoration of the occupation of weaving.

  18. "I'm Telling You ... The Language Barrier Is the Most, the Biggest Challenge": Barriers to Education among Karen Refugee Women in Australia

    Science.gov (United States)

    Watkins, Paula G.; Razee, Husna; Richters, Juliet

    2012-01-01

    This article examines factors influencing English language education, participation and achievement among Karen refugee women in Australia. Data were drawn from ethnographic observations and interviews with 67 participants between 2009 and 2011, collected as part of a larger qualitative study exploring the well-being of Karen refugee women in…

  19. Double Consciousness in Helen Oyeyemi and Diana Evans

    OpenAIRE

    Cuder Domínguez, María Pilar

    2009-01-01

    The first novels published by Helen Oyeyemi and Diana Evans feature twins of mixed-race parentage--a Nigerian mother and an English father--, growing up in Britain. Eight-year-old Jessamy in Oyeyemi’s The Icarus Girl is unaware that she was born a twin, but on travelling to Nigeria she encounters a troublesome girl she seems unable to shake off, TillyTilly. Georgia and Bessi in Evans’s 26a are identical twins who share all their experiences until a visit to their mother’s homeland of Nigeria ...

  20. Re-development of the Mount Evans Womble Observatory

    Science.gov (United States)

    Stencel, Robert E.

    2017-01-01

    Mount Evans in the Colorado Front Range hosts one of the highest altitude observatories in the USA, at an elevation of 14,148 ft (4,312 m). The observatory is operated under a Forest Service use permit, recently renewed for another 30 years. At times, observing conditions (seeing, water vapor column, etc.) can be as good as anywhere. The existing twin 0.72 m f/21 R-C telescopes are solar powered and internet connected. However, jet stream winds in 2012 destroyed the 15 year old, 22.5 ft diameter Ash dome. The replacement, custom dome design/install was rushed, and suffers from a number of flaws. Given that, plus the aging telescope and operating system, we are planning, and seeking partners and investor funds, to re-develop the facility. Facets of this may include replacing the twin apertures with a single full-aperture telescope for remote operations and sky monitoring, replacing the flawed dome with an innovative dome design, renewable power upgrades, and outreach programs for the many thousands of mountain visitors seasonally. As elsewhere, we are grappling with increases in atmospheric water vapor and out-of-control regional light pollution growth, but believe that the site continues to hold great potential. Interested parties are invited to contact the first author for further information. Website: http://www.du.edu/~rstencel/MtEvans .

  1. Weaving Colors into a White Landscape: Unpacking the Silences in Karen Hesse's Children's Novel "Out of the Dust"

    Science.gov (United States)

    Simon, Lisa

    2008-01-01

    The children's novel "Out of the Dust" (Hesse, 1997) is an evocative portrayal of the drought and dust storms that devastated Midwestern farms in the 1930s. Through the voice of her 13-year-old narrator, Karen Hesse intertwines history and free verse poetry to create what many readers find to be a moving depiction of the Oklahoma…

  2. War trauma and torture experiences reported during public health screening of newly resettled Karen refugees: a qualitative study.

    Science.gov (United States)

    Cook, Tonya L; Shannon, Patricia J; Vinson, Gregory A; Letts, James P; Dwee, Ehtaw

    2015-04-08

    Karen refugees have suffered traumatic experiences that affect their physical and mental health in resettlement. The United States Centers for Disease Control and Prevention recommends assessing traumatic histories and mental health symptoms during initial public health screening. This article reports the traumatic experiences that Karen refugees were able to describe during a short screening and contributes knowledge to existing human rights documentation systems. Four semi-structured and open-ended items asked about lifetime experiences of war trauma and torture. Interviews were completed with adult, Karen refugees during their initial public health screening. Experiences of war trauma and torture were coded using the extensive Human Rights Information and Documentation (HURIDOCS) Micro-thesauri coding system. Additional codes were created to describe experiences not captured by existing codes. Over 85% of 179 Karen people interviewed experienced life-threatening war trauma. All participants who reported war trauma or torture stories were able to describe at least one event. New war trauma codes proposed include: widespread community fear, systematic destruction/burning of house or village, exposure to dead bodies, orphaned in the context of war, injury caused by a landmine, fear of Thai police or deportation from Thailand, and harm or killings in the context of war. New torture codes include: forced portering; forced to be a human landmine sweep; forced to be a soldier, including child soldier; forced contact with a dead body; and removal of the eyes. Karen refugees were able to report traumatic experiences in the context of a brief health screening. The findings confirm existing reports of human rights violations against Karen people and suggest that additional codes be added to the HURIDOCS Micro-thesauri system that is used by torture treatment centers. Understanding the nature of traumatic experiences of this group is important for health providers working

  3. Tosta Evans, 1953 (Lepidoptera: Hesperiidae): a new species from northeast Brazil, first description of the female of Tosta tosta Evans, 1953, and placement of the genus within Achlyodini.

    Science.gov (United States)

    Siewert, Ricardo Russo; Mielke, Olaf Hermann Hendrik; Casagrande, Mirna Martins

    2015-08-11

    A new species of Tosta Evans, 1953 from northeast Brazil is described: T. pseudospeculum Siewert, Mielke & Casagrande, sp. nov. Additionally, the female of Tosta tosta Evans, 1953, the type species of the genus, is described for the first time. Illustrations of adults and male and female genitalia for all studied species are provided, as well as a discussion of the placement of the genus within the tribe Achlyodini.

  4. Preliminary psychometric properties of a measure of Karen Horney's Tridimensional theory in children and adolescents.

    Science.gov (United States)

    Coolidge, Frederick L; Segal, Daniel L; Estey, Alisa J; Neuzil, Paula J

    2011-04-01

    This study established the psychometric properties of a child and adolescent version of the Horney-Coolidge Tridimensional Inventory (HCTI), which assesses psychoanalyst Karen Horney's theory of neurotic types. Parents of 302 children (ages 5 to 17 years; median age = 12.0 years) completed the new 45-item version of the HCTI and the Coolidge Personality and Neuropsychological Inventory (CPNI) about their children. The three main scales (Compliance, Aggression, and Detachment) had good internal scale reliability and excellent test-retest reliability. Principal components analysis supported Horney's three dimensions and a six-component substructure. There was also sufficient construct validity with personality disorder scales from the CPNI with the three HCTI dimensions and their six components. The implications of the findings are discussed for Horneyan theory. © 2010 Wiley Periodicals, Inc.

  5. Karen Horney's "resigned person" heralds DSM-III-R's borderline personality disorder.

    Science.gov (United States)

    Muller, R J

    1993-01-01

    It is shown here that what Karen Horney called the resignation solution to the problem of basic anxiety leads to psychopathology very similar to DSM-III-R's borderline personality disorder (BPD). Both the "resigned person" and the borderline personality show instability of self-image, social relationships, and mood, and live out the associated deficits with similar styles. While not specifically using the term "splitting", Horney showed how alternating expansive and self-effacing trends can coexist in the resigned person, and how these oscillations in self-other-world constitution influence the resigned person's behavior in a way similar to borderline splitting. Horney's descriptive and psychodynamic analysis of the resignation phenomenon elaborates and gives additional credibility to DSM-III-R's BPD as a diagnostic category.

  6. Reasons patients leave their nearest healthcare service to attend Karen Park Clinic, Pretoria North

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    Agnes T. Masango- Makgobela

    2013-01-01

    Full Text Available Background: Many patients move from one healthcare provider or facility to another, disturbing the continuity that enhances holistic patient care.Objectives: To investigate the reasons given by patients for attending Karen Park Clinic rather than the clinic nearest to their homes.Methods: A cross-sectional descriptive study was conducted during 2010. Three hundred and fifty patients attending Karen Park Clinic were given questionnaires to complete, with the following variables: place of residence; previous attendance at the clinic nearest their home; services available at their nearest clinic; and their willingness to attend their nearest clinic in future.Results: Respondents were from Soshanguve (153; 43.7%, Mabopane (92; 26.3%, Garankuwa (29; 8.3% and Hebron (20; 5.7% and most were women (271; 77.4% aged 26–45 (177; 50.6%. Eighty per cent (281 of the patients had visited their nearest clinic previously and 54 of these (19.2% said they would not return. The reasons for this were: long waiting time (88; 25.1%; long queues (84; 24%; rude staff (60; 17%; and no medication (39; 11.1%.Conclusion: The majority of patients who had attended their nearest clinic were adamant that they would not return. It is necessary to reduce waiting times, thus reducing long queues. This can be achieved by having adequate, satisfied healthcare providers to render a quality service and by organising training for management. Patients can thus be redirected to their nearest clinic and the health centre’s capacity can be increased by procuring adequate drugs. There is a need to follow up on patients’ complaints about staff attitudes.

  7. Sacred Spaces of Karen Refugees and Humanitarian Aid Across the Thailand-Burma Border

    Directory of Open Access Journals (Sweden)

    Alexander Horstmann

    2011-01-01

    Full Text Available In this article, I demonstrate that the Karen National Union (KNU was able to manipulate and politicise humanitarian aid in the Thailand-Burma borderland. I contend that in the context of the civil war in eastern Burma, Protestant Christianity provides a crucial vehicle for political mobilisation. The article shows that refugee camps in the Thai borderland become centres of proselytisation, and that Protestant evangelical and missionary networks open up passages across the Thai-Burmese border. The article thus considers a case where a homeland is constructed in the liminal space between two nations. Illegal emergency aid that doubles as missionary project reinforces the image of a helpless victim being vandalized by evil Burmese army. ----- Dieser Artikel zeigt auf, wie es der Karen National Union (KNU gelungen ist, die humanitäre Hilfe im Grenzgebiet zwischen Thailand und Burma für eigene Ziele zu manipulieren und zu politisieren. Ich argumentiere, dass das protestantische Christentum ein entscheidendes Vehikel zur politischen Mobilisierung im Kontext des Bürgerkriegs in Ost-Burma darstellt. Der Artikel zeigt, dass die Flüchtlingslager im thailändischen Grenzgebiet als Zentren der Missionierung dienen und dass die protestantisch-evangelikalen und missionarischen Netzwerke territoriale Korridore durch die thailändisch-burmesische Grenze öffnen. Wir sehen hier ein Fallbeispiel, wie eine imaginierte Nation in der Grenzerfahrung zweier Nationen konstruiert wird. Soforthilfe, die mit protestantischer Mission doppelt, verstärkt das Bild hilfloser Opfer, die von der burmesischen Armee vandalisiert werden.

  8. [Dermatomiositis and evans syndrome associated with HTLV-1 infection].

    Science.gov (United States)

    Loja-Oropeza, David; Zavala-Flores, Ernesto; Vilca-Vasquez, Maricela

    2016-03-01

    A 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Upon admission, she was drowsy, with a poor overall status, marked weight loss, dehydration, with presence of livedo reticularis in her lower extremities, and onychodystrophy and onycholysis on the toes of both feet. Western blot test was positive for human T-lymphotropic virus type 1 (HTLV-1). The patient evolved with recurrent hypoglycemia. Therefore, we report a case of dermatomyositis and Evans syndrome in the context of an HTLV-1 infection.

  9. A New Species of Mesoptychia (Lindb. A. Evans from California

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    Crandall-Stotler Barbara

    2013-07-01

    Full Text Available A small, endemic leafy liverwort found in the coastal redwood forests of Santa Cruz and Monterey Counties of California is described as a new species of Mesoptychia (Lindb. A. Evans, i.e., Mesoptychia polymorpha Stotler, Crand.-Stotl. & Bakalin, sp. nov. This new taxon is morphologically related to the suite of small-leafed species of the genus, including M. badensis (Gottsche ex Rabenh. L. Söderstr. & Váňa and M. morrisoncola (Horik. L. Söderstr. & Váňa, but is unique within the genus in having mature vegetative leaves and bracts that are undivided and apically rounded to emarginate, with bilobed to retuse leaves of restricted occurrence. Although this polymorphic species is paroicous, perianths expand without fertilization and sporophytes are unknown.

  10. The pivotal role of chelation as a stereochemical control element in non-Evans anti aldol product formation.

    Science.gov (United States)

    Shinisha, C B; Sunoj, Raghavan B

    2010-06-18

    The origin of stereoselective formation of Evans syn and non-Evans anti aldol products in the reaction between titanium enolate derived from N-succinyloxazolidinone and benzaldehyde is established by using transition-state modeling. The chelated transition-state model is found to hold the key to otherwise less likely non-Evans anti aldol product, whereas the nonchelated model offers a convincing rationalization toward Evans syn aldol product. The computed results are in agreement with the reported experimental observations.

  11. Assessing awareness and knowledge of hypertension in an at-risk population in the Karen ethnic rural community, Thasongyang, Thailand

    Directory of Open Access Journals (Sweden)

    Aung MN

    2012-06-01

    Full Text Available Myo Nyein Aung,1,2 Thaworn Lorga,2 Janthila Srikrajang,2 Nongluk Promtingkran,2 Suchart Kreuangchai,2 Wilawan Tonpanya,2 Phatchanan Vivarakanon,2 Puangpet Jaiin,2 Nara Praipaksin,3 Apiradee Payaprom41Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan; 2Boromarajonani College of Nursing Nakhon Lampang (BCNLP, Lampang, Thailand; 3Baan Rekati Health Station, Thasongyang, Thailand; 4Thasongyang Hospital, ThailandBackground: Hypertension is currently a global health concern. Rural and minority populations are increasingly exposed to risk factors as a result of urbanization, leading to hypertension and cardiovascular disease. We conducted a survey in the rural Karen community in Thasongyang District, Tak Province, Thailand, with the aims of determining: the distribution of blood pressure across different age groups; the prevalence of hypertension and other risk factors for cardiovascular diseases (CVDs, including diabetes, smoking, sedentary lifestyle, and excess alcohol use; knowledge and awareness of hypertension as a disease; and knowledge and awareness of risk factors for hypertension among the population at risk.Methods: This was a community-based, cross-sectional survey of 298 rural Karen residents. A set of questionnaires assessing lifestyle-related health risk behaviors and awareness and knowledge of hypertension were used. Blood pressure, fasting plasma glucose, weight, height, and waist circumference were measured.Results: Median systolic and diastolic blood pressures were 110 (range 100–120 mmHg and 70 (range 60–80 mmHg, respectively. High blood pressure was observed in more than 27% of the population, with 15% being hypertensive and 12% being prehypertensive. Multinomial logistic regression analysis showed that people in the Karen community who were aware of hypertension were less likely to be current smokers (odds ratio [OR] 0.53, confidence interval [CI] 0.29–0.97 and those with primary

  12. Embarazo y Síndrome de Evans: a propósito de un caso

    OpenAIRE

    Artucio, Santiago; Silva Ledesma, Rosina; Ben, Sebastián; Fiol, Verónica; Cóppola, Francisco; Clínica Ginecotocológica "A" Prof. Dr. Briozzo, Facultad de Medicina, Universidad de la República. Centro Hospitalario Pereira Rossell, Montevideo, Uruguay.

    2015-01-01

    El síndrome de Evans es la coexistencia de trombocitopenia autoinmune con anemia hemolítica autoinmune. Raramente se presenta durante el curso de un embarazo. Esto dificulta las opciones terapéuticas, dado que algunos de los agentes utilizados para el tratamiento son teratogénicos. Los efectos del síndrome de Evans en el feto y recién nacido se desconocen dado el escaso número de casos publicados.Presentamos el caso de una paciente con diagnóstico preconcepcional de síndrome de Evans, que pre...

  13. Hashimoto's thyroiditis associated Evans syndrome: A rare case report on the clustered autoimmune disease triad.

    Science.gov (United States)

    Koti, Kalyan; Thumma, Rayapa Reddy; Nagarajan, Swathanthra; Mathi, Atchyuta

    2013-07-01

    Evans syndrome is a rare combination of autoimmune hemolytic anemia and immune thrombocytopenia. Their association with autoimmune thyroid diseases has been reported by few authors; however, a sequential development of the Evans syndrome in cases of Hashimoto's thyroiditis is extremely rare. The clustering of these autoimmune diseases might share a common pathogenic pathway. We present the fourth such case in world literature, of a 34-year-old female diagnosed with Hashimoto's thyroiditis in 2006, who has been taking synthetic thyroid hormone since then. Her condition is now clinically complicated with the development of the Evans syndrome.

  14. Embarazo y Síndrome de Evans: a propósito de un caso

    OpenAIRE

    Artucio, Santiago; Silva Ledesma, Rosina; Ben, Sebastián; Fiol, Verónica; Cóppola, Francisco; Clínica Ginecotocológica "A" Prof. Dr. Briozzo, Facultad de Medicina, Universidad de la República. Centro Hospitalario Pereira Rossell, Montevideo, Uruguay.

    2015-01-01

    El síndrome de Evans es la coexistencia de trombocitopenia autoinmune con anemia hemolítica autoinmune. Raramente se presenta durante el curso de un embarazo. Esto dificulta las opciones terapéuticas, dado que algunos de los agentes utilizados para el tratamiento son teratogénicos. Los efectos del síndrome de Evans en el feto y recién nacido se desconocen dado el escaso número de casos publicados.Presentamos el caso de una paciente con diagnóstico preconcepcional de síndrome de Evans, que pre...

  15. Teratogenic effects of trichloroacetonitrile in the Long-Evans rat

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.K.; Randall, J.L.; Tocco, D.R.; York, R.G.; Stober, J.A.; Read, E.J.

    1988-08-01

    Trichloroacetonitrile (TCAN) is among a number of contaminants found in drinking water produced by reactions of chlorine with background organic material. Long-Evans rats were intubated with TCAN (0, 1, 7.5, 15, 35, 55 mg/kg) in a tricaprylin vehicle on gestation days 6-18. The highest dose tested (55 mg/kg) was lethal in 21% of the dams and produced 100% resorptions in two-thirds of the survivors. Only one maternal death was seen at the next-lower dose; however, fetal weight and viability were decreased in a dose-related manner. The percentage of embryolethality was 13.9% at the lowest dose and 78.4% at the high dose, with resorption of entire litters seen at 7.5 mg/kg and above. At all doses, cardiovascular (interventricular septal defect, levocardia, common carotid, and right-sided aortic arch and ductus arteriosus) and urogenital (hypoplastic, missing, misplaced and fused kidneys, and hypoplastic uterine horns) malformations were seen in the offspring. Frequency of these malformations was dose related, ranging from 8% to 35% at the 1.0- and 35-mg/kg doses, respectively. The incidence of total soft tissue malformations was statistically significant at 15 and 35 mg/kg. There were no significant treatment-related changes in the incidence of skeletal malformations. The no-effect dose was established by statistical analysis to be 1.0 mg/kg/day.

  16. Revisão de Elbella Evans e gêneros afins (Lepidoptera, Hesperiidae, Pyrrhopyginae Revision of Elbella Evans and related genera (Lepidoptera, Hesperiidae, Pyrrhopyginae

    Directory of Open Access Journals (Sweden)

    Olaf H. H Mielke

    1994-01-01

    Full Text Available A systematic study of the genera Microceris Watson, 1893, Elbella Evans, 1951, Parelbella. gen.n. (type species: Hesperia polyzona [Latreille, 1824], Pseudocroniades. gen.n. (type species: Ericides (sic machaon Westwood, [1852] and Protelbella, gen.n. (type species: Pyrrhopyga (sic alburna Mabille, 1891, a natural group of the Pyrrhopyginae, here called "Elbella Complex", is presented. The following are spp.n. and sspp.n.: Elbella intersecta paraensis, Brazil: Pará; Elbella intersecta rufitegula, Brazil: Pernambuco, Bahia, Minas Gerais, Espírito Santo and Rio de Janeiro State; Elbella viriditas boliviana, Bolivia: La Paz; Elbella lampra albociliata, Brazil: São Paulo, Paraná and Santa Catarina: Elbella azeta giffordi, Brazil: Distrito Federal and São Paulo; Elbella patrobas mexicana, Mexico: Chiapas and Quintana Roo; Elbella patrobas evansi, Colombia: Cauca, Caldas and Boyaca; Elbella patrobas tingo, Brazil: Rondonia and Peru: Huanuco and Madre de Dios; Elbella patrobas amazonica, Brazil: Amazonas; Parelbella peruana, Peru: Junin; Pseudocroniades machaon seabrai, Brazil: Rio de Janeiro State; Protelbella alburna brasiliensis, Brazil: Amazonas, Rondonia and Mato Grosso, and French Guiana: Montagne aux Cheveaux. The following genus is a syn.n.: Hegesippe Evans, 1951 of Elbella Evans, 1951. The following species and subspecies are syn.n.: Pyrrhopyga (sic semidentata Mabille, 1877 and Elbella intersecta ilona Evans, 1951 of Elbella intersecta intersecta (Herrich-Schäffer, 1869: Pyrrhopyge carriae Bell, 1931 of Elbella viriditas viriditas (Skinner, 1920; Pyrrhopyga (sic menecrates Mabille, 1878 and Pyrrhopyge margimmiscus Hayward, 1935 of Elbella lampra lampra (Hopffer, 1874; Elbella etna moda Evans, 1951 of Elbella etna Evans, 1951; Jemadia umbrata Mabille & Boullet, 1908 of Elbella patroclus patroclus (Plötz, 1879; Pyrrhopyga (sic jamina Butler, 1870 and Pyrrhopyga (sic zimra Hewitson, 1871 of Parelbella ahira ahira (Hewitson, 1857; Elbella

  17. Jung, Evans-Wentz and various other gurus.

    Science.gov (United States)

    McGuire, William

    2003-09-01

    How did Jung become deeply concerned with Asian religions and particularly with the Tibetan Buddhism of a Welshman from Trenton, New Jersey? Could that man be considered one of Jung's gurus? This essay begins six years after Jung, at twenty, was admitted to the medical school of Basel University and became a member of the Zofingiaverein, a student society. The next year he gave the first of a series of lectures on the interpretation of Christ as the model of the 'god-man', like the Apostle Paul, Confucius, Zoroaster and the Buddha, who was 'drummed into the Hindu boy'. (Jung's Zofingia Lectures were discovered only after his death, in 1961, and were published in English in 1983). The present essay discusses Jung's early Buddhist interest as displayed in The Psychology of the Unconscious (finally, in a revision, entitled Symbols of Transformation), in Psychological Types and later in his foreword of the Wilhelm translation of the I Ching. Jung was influenced by the gurus Richard Wilhelm and his son Hellmut, the scholar J. W. Hauer (with whom he later broke off relations because of Hauer's Nazi politics), the indologist Heinrich Zimmer, and the Zen master D. T. Suzuki. Walter Yeeling Wentz was born in Trenton in 1878 and brought up in his family's theosophist faith. The Wentzes moved to San Diego in 1900, and Walter added his mother's Celtic surname, Evans, to the German Wentz. He was educated at Stanford University and travelled in Europe, studying Celtic folklore, and widely in the Near East, Tibet, India, and Oxford--studying religions everywhere and editing Tibetan books. He lived his last decades in San Diego and conducted a correspondence with Jung, while living in a cheap hotel, or in an ashram.

  18. Household ecology and out-migration among ethnic Karen along the Thai-Myanmar border

    Directory of Open Access Journals (Sweden)

    Daniel M. Parker

    2014-04-01

    Full Text Available Background: Local migration in developing-world settings, particularly among rural populations, is an important yet understudied demographic process. Research on migration in such populations can help us test and inform anthropological and demographic theory. Furthermore, it can lead to a better understanding of modern population distributions and epidemiologic landscapes. Objective: The purpose of this study was to investigate the potential relationships between household- and individual-level factors on out-migration among Karen villagers along the Thai-Myanmar border. Methods: We used a random effects hazard model to investigate the relationship of household consumer-producer (C/P ratios, the number of household members, and an individual's sex on the odds of outmigration. We then used simulations in order to test the sensitivity of our model to our C/P ratio weighting scheme. Results: We found that the number of household members is predictive of increased out-migration. Household C/P ratios were positively associated with out-migration in children but negatively associated with out-migration in working age adults. Finally, adult males were much more likely to move out of the household than were adult females. Conclusions: While household-level factors are important with regard to out-migration, the relationships between such household-level factors and out-migration are complex and vary by the individual's age and sex. Our study offers two novel concepts to household demography and migration studies. First, this study offers a new approach to evaluating weighting schemes for C/P ratios. Second, we show that household level factors are important at units of time (two-week intervals that are not normally studied by demographers.

  19. Knowledge of communicable and noncommunicable diseases among Karen ethnic high school students in rural Thasongyang, the far northwest of Thailand

    Directory of Open Access Journals (Sweden)

    Lorga T

    2013-07-01

    Full Text Available Thaworn Lorga,1 Myo Nyein Aung,1,2 Prissana Naunboonruang,1 Piyatida Junlapeeya,1 Apiradee Payaprom31Boromarajonani College of Nursing Nakhon Lampang (BCNLP, Lampang, Thailand; 2Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan; 3Thasongyang Hospital, Thasongyang, Tak, ThailandBackground: The double burden of communicable and noncommunicable diseases (NCD is an increasing trend in low- and-middle income developing countries. Rural and minority populations are underserved and likely to be affected severely by these burdens. Knowledge among young people could provide immunity to such diseases within a community in the long term. In this study we aimed to assess the knowledge of several highly prevalent NCDs (diabetes, hypertension, and chronic obstructive pulmonary disease [COPD] and several highly incident communicable diseases (malaria and diarrheal diseases among Karen high school students in a rural district in far northwest of Thailand. The aim of the study is to explore information for devising life-course health education that will be strategically based in schools.Method: A cross-sectional survey approved by the ethics committee of Boromarajonani College of Nursing Nakhon Lampang (BCNLP, Lampang, Thailand was conducted in Thasongyang, Tak province, from September 2011 to January 2012. Questionnaires for assessing knowledge regarding diabetes, hypertension, COPD, malaria, and diarrheal diseases were delivered to all 457 Karen high school students attending Thasongyang high school. A total of 371 students returned the questionnaires. Experts' validation and split-half reliability assessment was applied to the instrument.Results: Students' main sources of health information were their teachers (62%, health care workers (60%, television (59%, and parents (54%. Familial risk factors of diabetes and hypertension were not known to more than two thirds of the students. Except obesity and physical

  20. Molecular characterization of hereditary persistence of fetal hemoglobin in the Karen people of Thailand.

    Science.gov (United States)

    Trachoo, Objoon; Sura, Thanyachai; Sakuntabhai, Anavaj; Singhasivanon, Pratap; Krudsood, Srivicha; Phimpraphi, Waraphon; Krasaesub, Somporn; Chanjarunee, Suporn; Looareesuwan, Sornchai

    2003-05-01

    Hereditary persistence of fetal hemoglobin (HPFH) is the condition whereby a continuously active gamma-globin gene expression leads to elevated fetal hemoglobin (Hb F) levels in adult life [Stamatoyannopoulos G, Grosveld F. Hemoglobin switching. In: Stamatoyannopoulos G, Majerus PW, Perlmutter RM, Varmus H, eds. The Molecular Basis of Blood Diseases. Philadelphia: W.B. Saunders, 2001:135-182; Wood WG. Hereditary persistence of fetal hemoglobin and delta(beta) thalassemia. In: Steinberg MH, Forget BG, Higgs DR, Nagel RL, eds. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. Cambridge: Cambridge University Press, 2001:356-388; and Weatherall DJ, Clegg JB. Hereditary persistence of fetal hemoglobin. In: Weatherall DJ, Clegg JB, eds. The Thalassaemia Syndromes. Oxford: Blackwell Scientific Publishers, 1981:450-507]. The condition is caused either by mutation of the beta- and gamma-globin genes, or the gamma-gene controlled region on other chromosomes. Several families with this condition have been reported from Vietnam, Cambodia and China, and the Southeast Asian mutation (or HPFH-6), a 27 kb deletion, was demonstrated. Here we report on a mother and her daughter of the Karen ethnic group with high levels of Hb F, living in the Suan Pueng District on the border of Thailand and Myanmar. Genotyping showed a heterozygosity for the 27 kb deletion of the beta-globin gene. Their conditions have been confirmed by gap polymerase chain reaction (PCR) with three oligonucleotide primers recently developed by Xu et al. [Xu X-M, Li Z-Q, Liu Z-Y, Zhong X-L, Zhao Y-Z, Mo Q-H. Molecular characterization and PCR detection of a deletional HPFH: application to rapid prenatal diagnosis for compound heterozygotes of this defect with beta-thalassemia in a Chinese family. Am J Hematol 2000; 65:183-188.], and a DNA sequencing method. Thus far there has been no official report of the HPFH-6 anomaly from Thailand. The compound heterozygosity of beta-thalassemia (thal

  1. Complications of Evans' syndrome in an infant with hereditary spherocytosis: a case report

    Directory of Open Access Journals (Sweden)

    Kuwana Masataka

    2009-09-01

    Full Text Available Abstract Hereditary spherocytosis (HS is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice and splenomegaly. Evans' syndrome is a clinical syndrome characterized by autoimmune hemolytic anemia (AIHA accompanied by immune thrombocytopenic purpura (ITP. It results from a malfunction of the immune system that produces multiple autoantibodies targeting at least red blood cells and platelets. HS and Evans' syndrome have different mechanisms of pathophysiology one another. We reported the quite rare case of an infant who had these diseases concurrently. Possible explanations of the unexpected complication are discussed.

  2. Síndrome de Evans de aparición súbita en el embarazo

    OpenAIRE

    Jorge Barboza-Retana; Pilar Bogantes-Ledezma; William Carballo-Gutiérrez; Jorge Díaz-Camacho

    2011-01-01

    La trombocitopenia complica hasta el 10% de los embarazos. El síndrome de Evans es la coexistencia de la trombocitopenia inmune con anemia hemolítica autoinmune. Se presenta un caso de síndrome de Evans durante el embarazo, complicado por preclampsia y neutropenia fetal. Una mujer de 20 años de edad, previamente sana, primigesta, que presentó a las 34 semanas de gestación dolor epigástrico, trombocitopenia y pre eclampsia. Se le realizó parto por cesárea, por presentar síndrome de HELLP. A lo...

  3. Modified Evans peroneus brevis lateral ankle stabilization for balancing varus ankle contracture during total ankle replacement.

    Science.gov (United States)

    Roukis, Thomas S

    2013-01-01

    Lateral ankle instability is frequently encountered when performing total ankle replacement and remains a challenge. In the present techniques report, I have described a modification of the Evans peroneus brevis tendon lateral ankle stabilization harvested through limited incisions using simple topographic anatomic landmarks. The harvested peroneus brevis is then transferred either to the anterior distal tibia concomitantly with total ankle replacement or through the tibia when performed after total ankle replacement and secured with plate and screw fixation. This modified Evans peroneus brevis tendon is useful in providing lateral ankle stability during or after primary and revision total ankle replacement.

  4. Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome

    Directory of Open Access Journals (Sweden)

    Piero Farruggia

    2011-05-01

    Full Text Available Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening; thus it represents a excellent treatment challenge for the pediatric hematologist. First line treatment consists of steroids and/or immunoglobulin; further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We describe a baby with refractory Evans Syndrome that was cured by prolonged administration of mycophenolate mofetil and remained disease-free for 4 years after the discontinuation of treatment.

  5. Revisão de Elbella Evans e gêneros afins (Lepidoptera, Hesperiidae, Pyrrhopyginae) Revision of Elbella Evans and related genera (Lepidoptera, Hesperiidae, Pyrrhopyginae)

    OpenAIRE

    Mielke,Olaf H.H.

    1994-01-01

    A systematic study of the genera Microceris Watson, 1893, Elbella Evans, 1951, Parelbella. gen.n. (type species: Hesperia polyzona [Latreille, 1824]), Pseudocroniades. gen.n. (type species: Ericides (sic) machaon Westwood, [1852]) and Protelbella, gen.n. (type species: Pyrrhopyga (sic) alburna Mabille, 1891), a natural group of the Pyrrhopyginae, here called "Elbella Complex", is presented. The following are spp.n. and sspp.n.: Elbella intersecta paraensis, Brazil: Pará; Elbella intersecta ru...

  6. The Armenian minister for trade and economic development Karen Chshmaritian, visited CERN on 4 July and toured the ATLAS experimental cavern and assembly hall

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Armenian Minister for Trade and Economic Development, K. Chshmaritian third from right with from left to right : Aram Kotzinian, JINR, Dubna; Dr Marzio Nessi, ATLAS, Zohrad Mnatsakanian, Ambassador at the Permanent Mission of the Republic of Armenia in Geneva, Karen Chshmaritian, Armenian Minister for Trade and Economic Development, Alexey Sissakian, Vice-Director of JINR and Peter Jenni, ATLAS Spokesperson.

  7. EVALUATION OF SENSORY EVOKED POTENTIALS IN LONG EVANS RATS GESTATIONALLY EXPOSED TO MERCURY (HGO) VAPOR.

    Science.gov (United States)

    Human exposure to mercury vapor (Hg0) has been reported to result in sensory disturbances. Developmental exposure to toxicants may result in long-lasting changes in neural function. This manuscript describes the lack of effect of gestational exposure of Long Evans rats to Hg0 on ...

  8. Perturbations to the Lower Ionosphere by Tropical Cyclone Evan in the South Pacific Region

    DEFF Research Database (Denmark)

    Kumar, Sushil; Amor, Samir Nait; Chanrion, Olivier

    2017-01-01

    ) observed during tropical cyclone (TC) Evan, 9-16 December 2012 when TC was in the proximity of the transmitter-receiver links. We observed a maximum amplitude perturbation of 5.7dB on JJI transmitter during 16 December event. From Long Wave Propagation Capability model applied to three selected events we...

  9. Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate

    Directory of Open Access Journals (Sweden)

    Makoto Nakajima

    2011-06-01

    Full Text Available Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral b-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic b-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.

  10. BROMATE-INDUCED TRANSCRIPTIONAL CHANGES IN LONG-EVANS RAT KIDNEYS

    Science.gov (United States)

    Bromate-Induced Transcriptional Changes in Long-Evans Rat Kidneys.Ozone disinfection of surface waters containing bromide ion (Br-) results in the oxidation of bromide to bromate, which can be found in finished drinking water as a by-product. Potassium bromate (KBrO3)...

  11. On the behavior of Brønsted-Evans-Polanyi relations for transition metal oxides

    DEFF Research Database (Denmark)

    Vojvodic, Aleksandra; Vallejo, Federico Calle; Guo, Wei

    2011-01-01

    Versatile Brønsted-Evans-Polanyi (BEP) relations are found from density functional theory for a wide range of transition metal oxides including rutiles and perovskites. For oxides, the relation depends on the type of oxide, the active site, and the dissociating molecule. The slope of the BEP...

  12. Splenic marginal zone lymphoma with Evans' syndrome, autoimmunity, and peripheral gamma/delta T cells

    OpenAIRE

    2008-01-01

    Splenic marginal zone lymphoma with Evans? syndrome, autoimmunity, and peripheral gamma/delta T cells (Garcia-Mu?oz, Ricardo) Hematology Service, Clinica Universitaria, University of Navarra - Pamplona - SPAIN (Garcia-Mu?oz, Ricardo) Hematology Service, Clinica Universitaria, University of Navarra - Pamplona - SPAIN (Rodriguez-Otero, Paula) Hematology Service, Clinica Universitaria, University of Navarra - Pamplona - SPAIN (Pegenaute, Carlota) Department of...

  13. Autoimmune hemolytic anemia, as part of Evans' syndrome, caused by cold reactive IgG autoantibodies

    NARCIS (Netherlands)

    Jaarsma, AS; Muis, N; DeGraaf, SSN

    1996-01-01

    We describe a boy with Evans' syndrome, consisting of immune thrombocytopenic purpura at age 2 and autoimmune hemolytic anemia (AIHA) at age 4. AIHA was caused by cold Ige autoantibodies. This is unusual because AIHA is generally associated with either warm IgG antibodies or cold IgM antibodies. Tre

  14. Sows' Ears and Silk Purses: A Rejoinder to Evans and Saxe.

    Science.gov (United States)

    Grant, S. G.; Tzetzo, Kathryn

    1998-01-01

    Relates questions that the authors' asked when reviewing Ronald Evans and David Saxe's "Handbook on Teaching Social Education." Extends points from the original review: (1) the "Handbook" sends mixed messages about the nature of issues-centered teaching; and (2) it leaves unanswered questions concerning the relationship between…

  15. Síndrome de Evans de aparición súbita en el embarazo Evans Syndrome of Sudden onset in Pregnancy

    Directory of Open Access Journals (Sweden)

    Jorge Barboza-Retana

    2011-12-01

    Full Text Available La trombocitopenia complica hasta el 10% de los embarazos. El síndrome de Evans es la coexistencia de la trombocitopenia inmune con anemia hemolítica autoinmune. Se presenta un caso de síndrome de Evans durante el embarazo, complicado por preclampsia y neutropenia fetal. Una mujer de 20 años de edad, previamente sana, primigesta, que presentó a las 34 semanas de gestación dolor epigástrico, trombocitopenia y pre eclampsia. Se le realizó parto por cesárea, por presentar síndrome de HELLP. A los 25 días de postparto, reingresó al Hospital con trombocitopenia severa, plaquetas 2000 x mm³, anemia, hemoglobina 5,3 g/dl y fiebre. El Coombs directo fue positivo y el análisis posterior demostró la presencia de anticuerpos anti-plaquetarios, y anticardiolipina. Recibió transfusiones de sangre y plaquetas. Se le trató con prednisona, plasmaferesis, azatioprina y finalmente, resolvió su cuadro clínico después de 10 días de internamiento en una unidad de cuidado intensivo.Thrombocytopenia complicates up to 10% of pregnancies. Evans syndrome is the coexistence of immune thrombocytopenia with autoimmune hemolytic anemia. We report a case of Evans syndrome during pregnancy complicated by preeclampsia and fetal neutropenia. A 20year-old primigravida, previously healthy, presented at 34 weeks of gestation epigastric pain, thrombocytopenia and preeclampsia. She underwent cesarean delivery for HELLP syndrome. In the 25th postpartum day, she was readmitted to the hospital with severe thrombocytopenia, platelet count in 2000x mm³, anemia, hemoglobin 5.3 g/dl and fever. The direct Coombs was positive and subsequent analysis showed the presence of platelet antibodies, and anticardiolipin. She received blood and platelet transfusions. She was treated with prednisone, plasmapheresis, azathioprine, and finally recovered 10 days in an intensive care unit.

  16. Automated method to compute Evans index for diagnosis of idiopathic normal pressure hydrocephalus on brain CT images

    Science.gov (United States)

    Takahashi, Noriyuki; Kinoshita, Toshibumi; Ohmura, Tomomi; Matsuyama, Eri; Toyoshima, Hideto

    2017-03-01

    The early diagnosis of idiopathic normal pressure hydrocephalus (iNPH) considered as a treatable dementia is important. The iNPH causes enlargement of lateral ventricles (LVs). The degree of the enlargement of the LVs on CT or MR images is evaluated by using a diagnostic imaging criterion, Evans index. Evans index is defined as the ratio of the maximal width of frontal horns (FH) of the LVs to the maximal width of the inner skull (IS). Evans index is the most commonly used parameter for the evaluation of ventricular enlargement. However, manual measurement of Evans index is a time-consuming process. In this study, we present an automated method to compute Evans index on brain CT images. The algorithm of the method consisted of five major steps: standardization of CT data to an atlas, extraction of FH and IS regions, the search for the outmost points of bilateral FH regions, determination of the maximal widths of both the FH and the IS, and calculation of Evans index. The standardization to the atlas was performed by using linear affine transformation and non-linear wrapping techniques. The FH regions were segmented by using a three dimensional region growing technique. This scheme was applied to CT scans from 44 subjects, including 13 iNPH patients. The average difference in Evans index between the proposed method and manual measurement was 0.01 (1.6%), and the correlation coefficient of these data for the Evans index was 0.98. Therefore, this computerized method may have the potential to accurately compute Evans index for the diagnosis of iNPH on CT images.

  17. Transition state models for probing stereoinduction in Evans chiral auxiliary-based asymmetric aldol reactions.

    Science.gov (United States)

    Shinisha, C B; Sunoj, Raghavan B

    2010-09-08

    The use of chiral auxiliaries is one of the most fundamental protocols employed in asymmetric synthesis. In the present study, stereoselectivity-determining factors in a chiral auxiliary-based asymmetric aldol reaction promoted by TiCl(4) are investigated by using density functional theory methods. The aldol reaction between chiral titanium enolate [derived from Evans propionyl oxazolidinone (1a) and its variants oxazolidinethione (1b) and thiazolidinethione (1c)] and benzaldehyde is examined by using transition-state modeling. Different stereochemical possibilities for the addition of titanium enolates to aldehyde are compared. On the basis of the coordination of the carbonyl/thiocarbonyl group of the chiral auxiliary with titanium, both pathways involving nonchelated and chelated transition states (TSs) are considered. The computed relative energies of the stereoselectivity-determining C-C bond formation TSs in the nonchelated pathway, for both 1a and 1c, indicate a preference toward Evans syn aldol product. The presence of a ring carbonyl or thiocarbonyl group in the chiral auxiliary renders the formation of neutral TiCl(3)-enolate, which otherwise is energetically less favored as compared to the anionic TiCl(4)-enolate. Hence, under suitable conditions, the reaction between titanium enolate and aldehyde is expected to be viable through chelated TSs leading to the selective formation of non-Evans syn aldol product. Experimentally known high stereoselectivity toward Evans syn aldol product is effectively rationalized by using the larger energy differences between the corresponding diastereomeric TSs. In both chelated and nonchelated pathways, the attack by the less hindered face of the enolate on aldehyde through a chair-like TS with an equatorial disposition of the aldehydic substituent is identified as the preferred mode. The steric hindrance offered by the isopropyl group and the possible chelation are identified as the key reasons behind the interesting

  18. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease.

    OpenAIRE

    Li, Y; Togashi, Y; S. Sato; Emoto, T; J. H. Kang; TAKEICHI N.; Kobayashi, H; Y. Kojima; Une, Y.; Uchino, J

    1991-01-01

    Long-Evans Cinnamon (LEC) rats, an inbred strain of a mutant rat isolated from Long-Evans rats, develop hereditary hepatitis. To elucidate the role of copper metabolism in the development of the hepatitis in LEC rats, we examined the copper concentration in the tissues and serum levels of copper and ceruloplasmin. Copper concentration in the liver of LEC rats was over 40 times that of normal Long-Evans Agouti (LEA) rats, while the serum ceruloplasmin and copper concentrations in LEC rats decr...

  19. Therapeutic management of evans syndrome in a pregnancy with maternal systemic lupus erythematosus.

    Science.gov (United States)

    Nause, S L; Spiegler, J; Weichert, J; Hartge, D R

    2015-08-01

    A 31-year-old 2 G 1 P was referred to our unit of prenatal medicine at 35+3 weeks of gestation with a spontaneously conceived singleton pregnancy of a female fetus without detectable anomalies. Maternal hematological evaluation revealed an Evans-syndrome-related thrombocytopenia based on a lupus erythematosus. The former delivery was aggravated by a severe hemorrhage several years before. Anti-autoimmunologic therapy was started and maternal platelets count increased to physiological values. Uneventful ceasarean section was performed at 37 weeks of gestation with favourable outcome for mother and child. This case is the first report of a successful therapy in maternal Evans syndrome in pregnancy combined with a lupus erythematosus.

  20. Reverse Evans peroneus brevis medial ankle stabilization for balancing valgus ankle contracture during total ankle replacement.

    Science.gov (United States)

    Roukis, Thomas S; Prissel, Mark A

    2014-01-01

    Medial ankle instability secondary to deltoid ligament insufficiency is frequently encountered when performing total ankle replacement and remains a challenge. In the present techniques report, we describe a "reverse" Evans peroneus brevis tendon nonanatomic deltoid ligament reconstruction for medial ankle stabilization harvested through limited incisions using simple topographic anatomic landmarks. The harvested peroneus brevis tendon is brought through a drill hole in the talus from laterally to medially, aiming for the junction of the talar neck and body plantar to the midline. The tendon is the brought superiorly and obliquely to the anterior medial aspect of the distal tibia where it is secured under a plate and screw construct. This modified Evans peroneus brevis tendon nonanatomic deltoid ligament reconstruction is useful in providing medial ankle stability during or after primary and revision total ankle replacement.

  1. Distribution of albumin in the normal monkey eye as revealed by Evans blue fluorescence microscopy.

    Science.gov (United States)

    Radius, R L; Anderson, D R

    1980-03-01

    Since intravenously injected Evans blue binds irreversibly to serum albumin, its distribution reflects albumin exchange between the intravascular and extravascular tissue compartments. In histologic specimens examined by fluorescence, microscopy, extravasated Evans blue--albumin complex was identified within the ciliary body and trabecular meshwork of normal monkey eyes. In eyes fixed by intra-arterial perfusion of fixative, no dye was identified in the choroid, retina, or optic nerve. With immersion fixation, however, some extravasation was seen in the choroid and adjacent optic nerve. In some specimens, the optic nerve was stained not only with material apparently leaking from the choroid but also from a breakdown of the blood-brain barrier in the major disc vasculature during the interval before fixative penetrates into the tissue. Perfusion fixation must be used to avoid this artifact, and freezing techniques would be even better.

  2. Enantioselective Synthesis of Antiepileptic Agent, (−-Levetiracetam, through Evans Asymmetric Strategy

    Directory of Open Access Journals (Sweden)

    K. Chandra Babu

    2013-01-01

    Full Text Available A practical and efficient enantioselective synthesis of antiepileptic drug, (−-Levetiracetam, has been described in five steps (33.0% overall yield and high optical purity (99.0% ee, using Evans asymmetric strategy for α-alkylation of carbonyl functionality as the key step. The simplicity of the experimental procedures and high stereochemical outcome make this method synthetically attractive for preparing the target compound on multigram scales.

  3. Enantioselective Synthesis of Antiepileptic Agent, (−)-Levetiracetam, through Evans Asymmetric Strategy

    OpenAIRE

    Chandra Babu, K.; Buchi Reddy, R.; Mukkanti, K.; Suresh, K.; Madhusudhan, G.; Satish Nigam

    2013-01-01

    A practical and efficient enantioselective synthesis of antiepileptic drug, (−)-Levetiracetam, has been described in five steps (33.0% overall yield) and high optical purity (99.0% ee), using Evans asymmetric strategy for α-alkylation of carbonyl functionality as the key step. The simplicity of the experimental procedures and high stereochemical outcome make this method synthetically attractive for preparing the target compound on multigram scales.

  4. ATRAZINE INCREASES DIMETHYLBENZ[A]ANTHRACENE-INDUCED MAMMARY TUMOR INCIDENCE IN LONG EVANS OFFSPRING EXPOSED IN UTERO

    Science.gov (United States)

    ATRAZINE INCREASES DIMETHYLBENZ[A]ANTHRACENE-INDUCED MAMMARY TUMOR INCIDENCE IN LONG EVANS OFFSPRING EXPOSED IN UTERO.SE Fenton and CC DavisReproductive Toxicology Division, NHEERL, ORD, USEPA, Durham, NC, USARecently, we found that ATR exposure during ma...

  5. The moreau-evans hydrodynamic model applied to actual hall-héroult cells

    Science.gov (United States)

    Moreau, René J.; Ziegler, Donald

    1988-10-01

    An extension of the Moreau-Evans[1] model for Hall-Héroult cells hydrodynamics is presented. Numerical techniques are used to solve the Moreau-Evans model equations with realistic electromagnetic force fields; the predicted results are compared with those of another model which is the property of Kaiser Aluminum Company and whose results are considered as in fairly good agreement with available measurements (velocity in aluminum, for instance). The main input in this hydrodynamic model, i.e., the electromagnetic force field throughout the two liquids, was previously computed. For a given cell design these data were calculated using the electromagnetic program of Lympany and Evans.[2] For actual cells the forces were deduced from measurements of the magnetic field provided by Kaiser Aluminum Company. As expected, the cryolite flow is found to be governed by the large channels, and to be strongly dependent on the presence of such a channel between the two files of anodes. The use of numerical solution has made possible the analysis of new effects as the interfacial drag and the influence of small channels between anode blocks.

  6. Comorbid presentation of severe novel influenza A (H1N1) and Evans syndrome: a case report

    Institute of Scientific and Technical Information of China (English)

    CHEN Hui; JIA Xin-lei; GAO Heng-miao; QIAN Su-yun

    2011-01-01

    One 22-month-old boy who was admitted for a fever lasting 6 days as well as a cough and wheezing lasting 2 days was reported. He was diagnosed with influenza A (H1N1, severe type), severe pneumonia, acute respiratory distress syndrome (ARDS), Evans syndrome and multiple organ failure. This is the first case of novel influenza A (H1N1) and Evans syndrome. The pathogenesis is still unknown.

  7. Assis, Machado de. Ressurrection by Machado de Assis. Trad. Karen Sherwood Sotelino. Pittsburgh: Latin American Literary Review Press, 2013. 162 p.

    Directory of Open Access Journals (Sweden)

    Cynthia Beatrice Costa

    2015-12-01

    Full Text Available Resenha crítica da primeira e única tradução para o inglês do romance machadiano Ressurreição, publicado em 1872. Lançada em 2013, a tradução da professora da Universidade de Stanford Karen Sherwood Sotelino chamou a atenção de estudiosos de Machado por mostrar como a obra do autor brasileiro desperta interesse atual no mundo anglófono.

  8. Public knowledge of diabetes in Karen Ethnic rural residents: a community-based questionnaires study in the far north-west of Thailand

    Directory of Open Access Journals (Sweden)

    Lorga T

    2012-09-01

    Full Text Available Thaworn Lorga,1 Kannapatch Srithong,1 Pratumpan Manokulanan,1 Thin Nyein Nyein Aung,2 Myo Nyein Aung1,31Boromrajonani College of Nursing Nakhon Lampang (BCNLP, Lampang, Thailand; 2University of Medicine, Mandalay, Myanmar; 3Department of Public Health, Graduate School of Medicine Juntendo University, Tokyo, JapanBackground and purpose: The public knowledge of diabetes is important for prevention of disease. This study aimed to evaluate knowledge of diabetes, risk factors, and the common warning signs of diabetes and complications among community participants in a rural Karen ethnic community.Methods: Participants were asked to answer a questionnaire regarding their knowledge of diabetes. Fasting blood glucose testing, blood pressure measurement, and body mass index (BMI assessment were provided to the participants. The study was conducted at Thasongyang district, Tak province, Thailand.Results: A total of 299 Karen rural residents were included in the study. The median age was 45 years and median fasting blood glucose was 88 mg/dL. The response rate to the questionnaires was 91.97%. Half of the participants knew diabetes is a noncommunicable disease needing lifelong treatment. Overall, one-third of the community participants could correctly answer the knowledge assessment questions regarding risk factors and common features of diabetes. Whereas the other two-thirds either gave a wrong answer or were “not sure”. Female participants had poorer diabetes knowledge than the males.Conclusion: The public knowledge of diabetes, as represented by this sample of the Karen ethic community, is alarmingly low. There is significant gender difference in knowledge level. Culturally tailored and gender-sensitive diabetes health education interventions are urgently needed in this minority ethnic community.Keywords: health education, gender differences, ethnic minority, diabetes, Karen

  9. Sacred Networks and Struggles among the Karen Baptists across the Thailand-Burma Border Réseaux sacrés et conflits parmi les Baptistes karen de part et d’autre de la frontière birmano-thaïlandaise

    Directory of Open Access Journals (Sweden)

    Alexander Horstmann

    2012-10-01

    Full Text Available In this article, I provide a case study of a moving border between Thailand and Burma. Emphasizing the agency of people who become refugees, the article is concerned to point out the important role of religious networks in providing humanitarian assistance, shelter and mobility to stateless Karen refugees. I argue that Christian and Buddhist literate networks- realigned in political exile, develop competing visions of a Karen “homeland.” Arguing that membership in the network is crucial for survival, the article follows the social organization and religious practices in Baptist networks. I examine how the Baptist church network in close partnership with the Karen National Union is able or not able to mobilize refugees for proselytization. Karen refugee leaders and KNU-pastors find analogies in the bible to find an explanation to the suffering of the Karen civil population in the war. The article is interested in the nexus and overlap of humanitarian ideology, Christianity and nationalism in the transitional space between Thailand and Burma. Providing case-studies of individual refugees, the article gives ethnographic sketches from the refugee camp, the countryside and humanitarian assistance to the internally displaced.Cet article est une étude de cas d’une frontière mouvante entre la Thaïlande et la Birmanie. Insistant sur l’agency (action de personnes devenues des réfugiés, l’article souligne le rôle important des réseaux religieux qui apportent une assistance humanitaire, des abris et de la mobilité à des réfugiés karen dépourvus d’État. Je soutiens que les réseaux intellectuels chrétiens et bouddhistes, recomposés dans l’exil, développent des visions concurrentes d’une « mère-patrie » karen. Soutenant que la participation au réseau est cruciale pour la survie, l’article développe plus particulièrement l’organisation sociale et les pratiques religieuses en vigueur dans les réseaux baptistes. J

  10. Vascular aldosterone production at the pre-diabetic stage of young Otsuka Long-Evans Tokushima Fatty (OLETF) rats, compared with Long-Evans Tokushima Otsuka (LETO) rats.

    Science.gov (United States)

    Matsuzawa, Yoko; Suematsu, Sachiko; Saito, Jun; Omura, Masao; Nishikawa, Tetsuo

    2013-12-13

    We examined the ability of aortic smooth muscle cells (AoSMC) prepared from spontaneously diabetic rats to produce aldosterone (Aldo) and the regulatory mechanism that controls their Aldo production. AoSMC of 6 week-old Long-Evans Tokushima Otsuka (LETO: the control group) and 6 week-old Otsuka Long-Evans Tokushima Fatty (OLETF: the type 2 diabetes group) rats were used in the present experiments. CYP11B2 (Aldo synthetase) mRNA expression was detected in both the LETO and OLETF AoSMC. Basal Aldo production was significantly greater (4-5 fold higher) in the OLETF AoSMC culture medium than in the LETO AoSMC culture medium. When AoSMC were co-incubated with high-density lipoproteins (HDL), supplying cholesterol as a substrate for steroidogenesis in rats, angiotensin II (AII) significantly increased greater Aldo production in the OLETF AoSMC than in the LETO AoSMC. The present data suggested that future onset of diabetic vascular dysfunction is partly caused by excess Aldo production by AoSMC in young OLETF rats. Concomitant stimulation by HDL and AII resulted in elevated Aldo production in the OLETF and the LETO AoSMC, and also demonstrated that AII-induced Aldo production is greatly enhanced by HDL in OLETF, rather than in LETO. In conclusion, our data clearly demonstrated that Aldo production in the OLETF AoSMC was significantly higher than in the LETO AoSMC, suggesting possible future onset of vascular dysfunction in diabetes, induced by local Aldo production in the AoSMC.

  11. A ética ecofeminista de Karen J. Warren: um modelo de ética ambiental genuína?

    Directory of Open Access Journals (Sweden)

    Daniela Rosendo

    2015-07-01

    Full Text Available http://dx.doi.org/10.5007/1807-1384.2015v12n1p16 Karen J. Warren apresenta uma proposta ética ecofeminista, segundo a qual os contextos precisam ler levados em consideração na análise de situações e problemas morais, rejeitando-se o monismo ético das correntes principais de ética animal. O objetivo deste artigo é mostrar, à luz da noção de vulnerabilidade, critério de considerabilidade moral proposto por Paul Taylor, que a ética sensível ao cuidado de Warren pode não ser considerada uma ética ambiental genuína, à medida que se aproxima do biorregionalismo de Gary Snyder e não esclarece de que forma a consideração moral é atribuída aos animais individualmente. Quanto ao relativismo, segundo os critérios de James Rachels e Peter Singer, a proposta de Warren parece não cumprir com os requisitos de uma ética imparcial e geral, e pode incorrer nos problemas do relativismo, uma vez que a concepção de cuidado da autora é limitada.

  12. Methamphetamine use and correlates in two villages of the highland ethnic Karen minority in northern Thailand: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Ono-Kihara Masako

    2009-05-01

    Full Text Available Abstract Background The prevalence of methamphetamine use and human immunodeficiency virus (HIV incidence are high in lowland Thai society. Despite increasing social and cultural mixing among residents of highland and lowland Thai societies, however, little is known about methamphetamine use among ethnic minority villagers in the highlands. Methods A cross-sectional survey examined Karen villagers from a developed and a less-developed village on February 24 and March 26, 2003 to evaluate the prevalence and social correlates of methamphetamine use in northern Thailand. Data were collected in face-to-face interviews using a structured questionnaire. Results The response rate was 79.3% (n = 548. In all, 9.9% (males 17.6%, females 1.7% of villagers reported methamphetamine use in the previous year. Methamphetamine was used mostly by males and was significantly related to primary or lower education; to ever having worked in town; to having used opium, marijuana, or heroin in the past year; and to ever having been diagnosed with a sexually transmitted infection (STI. Conclusion Since labor migration to towns is increasingly common among ethnic minorities, the prevention of methamphetamine use and of HIV/STI infection among methamphetamine users should be prioritized to prevent HIV in this minority population in Thailand.

  13. Evans blue staining of cardiomyocytes induced by myocardial contrast echocardiography in rats: evidence for necrosis instead of apoptosis.

    Science.gov (United States)

    Miller, Douglas L; Li, Peng; Dou, Chunyan; Armstrong, William F; Gordon, David

    2007-12-01

    High mechanical index (MI) echocardiography with contrast agent has been shown to induce Evans blue staining of cardiomyocytes, seen 1 d after exposure, in addition to contraction band necrosis, seen immediately after exposure. This research examined the roles of necrosis vs. apoptosis in these bioeffects. Myocardial contrast echocardiography at high MI with 1:4 electrocardiogram triggering was performed in anesthetized rats at 1.5 MHz. Histologically observable cell injury was accumulated by infusing a high dose of 50 microL/kg ultrasound contrast media via tail vein for 5 min at the start of 10 min of scanning. Evans blue dye or propidium iodide was injected as an indicator of cardiomyocyte plasma membrane integrity. Histologic sections were stained using the terminal dUTP nick-end labeling (TUNEL) method for labeling nuclei with DNA degradation (e.g., apoptosis). Evans blue fluorescent cells were counted on frozen sections or on hematoxylin-stained and TUNEL-labeled paraffin sections. In addition, transmission electron microscopy was used to assess potential apoptotic nuclei. Hypercontraction and propidium iodide staining were observed immediately after imaging exposure. Although TUNEL-positive cells were evident after 4 h, these also had indications of contraction band necrosis, and features of apoptosis were not confirmed by electron microscopy. Inflammatory cell infiltration was evident after 24 h. A second, more subtle injury was recognized by Evans blue staining, with minimal inflammatory cell infiltration at the morphologically intact stained cells after 24 h. Apoptosis was not detected by the TUNEL method in the cardiomyocytes stained with Evans blue at 24 h. However, Evans blue-stained cell numbers declined after 48 h, with continued inflammatory cell infiltration. The initial insult for Evans blue-stained cardiomyocytes apparently induced partial permeability of the plasma membrane, which led to gradual degeneration (but not apoptosis) and necrosis

  14. Evans Syndrome Presented with Marginal Zone Lymphoma and Duodenal Neuroendocrine Tumor in an Elderly Woman

    Directory of Open Access Journals (Sweden)

    Daniele D'Ambrosio

    2016-12-01

    Full Text Available Evans syndrome (ES is an autoimmune disorder characterized by simultaneous or sequential development of autoimmune hemolytic anemia, immune thrombocytopenia, and/or neutropenia. ES can be classified as a primary (idiopathic or secondary (associated with an underlying disease syndrome. We report a case of ES in an elderly patient in the presence of multiple trigger factors such as recent influenza vaccine, marginal zone lymphoma, and neuroendocrine tumor G1. Whether this association is casual or causal remains a matter of speculation. It is however necessary to have a thorough work-up in a newly diagnosed ES and a more accurate search of miscellaneous factors especially in elderly patients.

  15. Moniliophthora roreri (Cif y Par Evans et al. in the crop of cocoa

    Directory of Open Access Journals (Sweden)

    Fernando David Sánchez Mora

    2012-09-01

    Full Text Available More than a century, cacao (Theobroma cacao L. in Ecuador has been an important source of income for farmers and currency for the country, becoming one of the biggest exporters worldwide. Then, gradually lost that status due to the attack of diseases, including moniliasis caused by [Moniliophthora roreri (Cif and Par Evans et al.]. It can cause damage of up to 80% in production. Currently there is little scientific date information on its occurrence, symptoms, etiology, epidemiology, life cycle management or control strategies of that disease, by performing this review both these important topics, bringing with it to this area of knowledge.

  16. Síndrome de Evans de aparición súbita en el embarazo

    Directory of Open Access Journals (Sweden)

    Jorge Barboza-Retana

    2011-12-01

    Full Text Available La trombocitopenia complica hasta el 10% de los embarazos. El síndrome de Evans es la coexistencia de la trombocitopenia inmune con anemia hemolítica autoinmune. Se presenta un caso de síndrome de Evans durante el embarazo, complicado por preclampsia y neutropenia fetal. Una mujer de 20 años de edad, previamente sana, primigesta, que presentó a las 34 semanas de gestación dolor epigástrico, trombocitopenia y pre eclampsia. Se le realizó parto por cesárea, por presentar síndrome de HELLP. A los 25 días de postparto, reingresó al Hospital con trombocitopenia severa, plaquetas 2000 x mm³, anemia, hemoglobina 5,3 g/dl y fiebre. El Coombs directo fue positivo y el análisis posterior demostró la presencia de anticuerpos anti-plaquetarios, y anticardiolipina. Recibió transfusiones de sangre y plaquetas. Se le trató con prednisona, plasmaferesis, azatioprina y finalmente, resolvió su cuadro clínico después de 10 días de internamiento en una unidad de cuidado intensivo.

  17. Joint reproductive autonomy: does Evans v Amicus Healthcare Ltd provide for a gender-neutral approach to assisted reproductive rights?

    Science.gov (United States)

    Allin, Michael J

    2015-06-01

    Assisted reproductive technology encompasses methods of achieving pregnancy by artificial or partially artificial means. Whilst these methods are more commonly used by couples suffering from problems of infertility, some forms of assistance are employed by fertile couples, for example pre-implantation genetic diagnosis. The overall regulatory framework in the UK is predominantly found in the Human Fertilisation and Embryology Act 1990. The usual rules relating to consent and autonomy apply and were discussed in depth in Evans v Amicus Healthcare Ltd and later in Evans v United Kingdom. This paper considers whether the Evans litigation envisages the possibility of further encouraging joint autonomy in the use of zygotes and whether there is a continuing right to autonomy by the party not bearing the pregnancy.

  18. EL CASO KAREN ATALA: LA CONJUGACIÓN DE LA ORIENTACIÓN SEXUAL Y EL PRINCIPIO DEL INTERÉS SUPERIOR DEL MENOR

    OpenAIRE

    Sonia RODRÍGUEZ JIMÉNEZ

    2012-01-01

    Las presentes líneas abordan el caso Karen Atala vs. Chile, planteado como un nuevo reto tanto para la Comisión Interamericana de Derechos Humanos como para la Corte Interamericana de Derechos Humanos, al determinar el principio del interés superior del menor cuando uno de los progenitores tiene una orientación sexual diferente . El caso presenta la necesidad de encontrar el balance adecuado entre tres principios fundamentales: la no discriminación por orientación sexual, la igualdad, y e...

  19. Interview with a quality leader--Karen Davis, executive director of The Commonwealth Fund. Interview by Lecia A. Albright.

    Science.gov (United States)

    Davis, Karen

    2009-01-01

    Karen Davis is president of The Commonwealth Fund, a national philanthropy engaged in independent research on health and social policy issues. Dr. Davis is a nationally recognized economist, with a distinguished career in public policy and research. Before joining the Fund, she served as chairman of the Department of Health Policy and Management at The Johns Hopkins School of Public Health, where she also held an appointment as professor of economics. She served as deputy assistant secretary for health policy in the Department of Health and Human Services from 1977 to 1980, and was the first woman to head a U.S. Public Health Service agency. Before her government career, Ms. Davis was a senior fellow at the Brookings Institution in Washington, DC; a visiting lecturer at Harvard University; and an assistant professor of economics at Rice University. A native of Oklahoma, she received her PhD in economics from Rice University, which recognized her achievements with a Distinguished Alumna Award in 1991. Ms. Davis is the recipient of the 2000 Baxter-Allegiance Foundation Prize for Health Services Research. In the spring of 2001, Ms. Davis received an honorary doctorate in human letters from John Hopkins University. In 2006, she was selected for the Academy Health Distinguished Investigator Award for significant and lasting contributions to the field of health services research in addition to the Picker Award for Excellence in the Advancement of Patient Centered Care. Ms. Davis has published a number of significant books, monographs, and articles on health and social policy issues, including the landmark books HealthCare Cost Containment, Medicare Policy, National Health Insurance: Benefits, Costs, and Consequences, and Health and the War on Poverty. She serves on the Board of Visitors of Columbia University, School of Nursing, and is on the Board of Directors of the Geisinger Health System. She was elected to the Institute of Medicine (IOM) in 1975; has served two

  20. Taxonomic review of Gallio Evans, 1955 (Lepidoptera, Hesperiidae, Hesperiinae: one less monotypic genus of Moncini

    Directory of Open Access Journals (Sweden)

    Eduardo Carneiro

    2015-12-01

    Full Text Available ABSTRACT Moncini is the tribe of Hesperiidae that comprises the greatest diversity of small, brown, hard to identify skippers. The group is peculiarly classified as having many monotypic genera, thus offering low informative value to its systematics. This study presents a review of the genus Gallio Evans, 1955, a genus formerly recognized as monotypic, and describes three new species, Gallio imperatriz sp. nov. from Maranhão, Brazil, Gallio furtadoi sp. nov. from Mato Grosso, Brazil and Gallio eti sp. nov. from Madre de Díos, Peru and Acre, Brazil (type locality. A lectotype for Vehilius carasta Schaus, 1902 is designated. Gallio is therefore redescribed and illustrations and diagnosis to its species are provided.

  1. Spectroscopic study of the competitive interaction between streptomycin and Evans blue to bovine serum albumin

    Science.gov (United States)

    Huang, Jü-qin; Lv, Qing-luan; Wang, Huai You

    2011-12-01

    The mechanism of the competitive interaction of streptomycin and Evans blue (EB) to bovine serum albumin (BSA) has been studied by using both fluorimetry and spectrophtometry. Effects of pH, streptomycin and concentration of EB on the competitive interaction of streptomycin and EB were examined. A static fluorescence quenching process was confirmed in the light of Stern-Volmer plot. The test result showed that there were strong and weak binding sites on BSA molecule and the binding constant of EB-BSA complex and the number of binding site n were obtained. These facts revealed that the competitive interaction was occurred between EB and streptomycin, which can possibly provide useful message in investigation of the interaction of antibiotic with BSA.

  2. Measurement of vascular permeability in spinal cord using Evans Blue spectrophotometry and correction for turbidity.

    Science.gov (United States)

    Warnick, R E; Fike, J R; Chan, P H; Anderson, D K; Ross, G Y; Gutin, P H

    1995-05-01

    Vascular permeability can be visualized by Evans Blue (EB) extravasation and quantified by spectrophotometry after formamide extraction of the tissue. However, formamide extracts show significant turbidity, which may contribute to the total optical density at the wavelength of measurement (e.g., 620 lambda). We developed a simple method for estimating the component of the total optical density of a dyed specimen contributed by turbidity. Our method, which uses a determination of turbidity made at another point of the light spectrum (740 lambda), was more precise than two other EB quantification techniques. We therefore recommend it for individual correction of formamide extracts of spinal cord specimens. The application of this technique to the brain remains to be determined.

  3. Endogenous mycotic endophthalmitis in a dog with candiduria and Evans syndrome.

    Science.gov (United States)

    Enders, Andrew; van der Woerdt, Alexandra; Donovan, Taryn

    2017-01-01

    This report describes the clinical presentation, diagnosis, histologic lesions, and outcome of endogenous mycotic endophthalmitis secondary to candiduria in a three-year-old female spayed Dachshund. The dog was being treated for Evans syndrome for one month prior to being diagnosed with candiduria and fibrinous uveitis OS. The left eye was enucleated due to secondary glaucoma, and the fungal urinary tract infection was treated successfully. Uveitis developed in the contralateral eye with relapse of the urinary tract infection in the following weeks. The right eye was medically managed until secondary glaucoma developed and was subsequently enucleated. Histopathology of both eyes showed evidence of endophthalmitis with intralesional fungal organisms, consistent with Candida spp. Ocular candidiasis is rare in dogs. To the authors' knowledge, this is the first report of endogenous mycotic endophthalmitis with concurrent candiduria in a dog. © 2016 American College of Veterinary Ophthalmologists.

  4. On the behavior of Bronsted-Evans-Polanyi Relations for Transition Metal Oxides

    Energy Technology Data Exchange (ETDEWEB)

    Vojvodic, Aleksandra

    2011-08-22

    Versatile Broensted-Evans-Polanyi (BEP) relations are found from density functional theory for a wide range of transition metal oxides including rutiles and perovskites. For oxides, the relation depends on the type of oxide, the active site and the dissociating molecule. The slope of the BEP relation is strongly coupled to the adsorbate geometry in the transition state. If it is final state-like the dissociative chemisorption energy can be considered as a descriptor for the dissociation. If it is initial state-like, on the other hand, the dissociative chemisorption energy is not suitable as descriptor for the dissociation. Dissociation of molecules with strong intramolecular bonds belong to the former and molecules with weak intramolecular bonds to the latter group. We show, for the prototype system La-perovskites, that there is a 'cyclic' behavior in the transition state characteristics upon change of the active transition metal of the oxide.

  5. A Gallavotti-Cohen-Evans-Morriss Like Symmetry for a Class of Markov Jump Processes

    Science.gov (United States)

    Barato, Andre Cardoso; Chetrite, Raphaël; Hinrichsen, Haye; Mukamel, David

    2012-01-01

    We investigate a new symmetry of the large deviation function of certain time-integrated currents in non-equilibrium systems. The symmetry is similar to the well-known Gallavotti-Cohen-Evans-Morriss-symmetry for the entropy production, but it concerns a different functional of the stochastic trajectory. The symmetry can be found in a restricted class of Markov jump processes, where the network of microscopic transitions has a particular structure and the transition rates satisfy certain constraints. We provide three physical examples, where time-integrated observables display such a symmetry. Moreover, we argue that the origin of the symmetry can be traced back to time-reversal if stochastic trajectories are grouped appropriately.

  6. Public Lecture | The long road to the LHC | Prof. Lyn Evans, Dr. Daniel Treille and Prof. Peter Jenni | 9 October

    CERN Multimedia

    2014-01-01

    “The long road to the LHC” by Prof. Lyn Evans, Dr. Daniel Treille and Prof. Peter Jenni. Thursday 9 October, 7.30 p.m. in the Globe of Science and Innovation. Talk in English with simultaneous interpreting into French.  Entrance free. Limited number of seats. Reservation essential: +41 22 767 76 76 or cern.reception@cern.ch   Lyn Evans. Lecture by Lyn Evans Abstract The key to the discovery of the Higgs boson has been the development of particle accelerators at CERN over the years. I will explain how a particle accelerator works and will follow the path from the construction of the Proton Synchrotron in the 1950s to the world’s most powerful colliding beam machine, the Large Hadron Collider. Biography Born in 1945, Lyn Evans has spent his whole career in the field of high energy physics and particle accelerators, participating in all the great projects of CERN. From 1993 he led the team that designed, built and commissioned the LHC. He is currently ...

  7. Ann Hutchinson (as subject), Dr. Joan Vernikos (R), Dee O'Hara (L), J. Evans and E. Lowe pose for

    Science.gov (United States)

    1993-01-01

    Ann Hutchinson (as subject), Dr. Joan Vernikos (R), Dee O'Hara (L), J. Evans and E. Lowe pose for pictures in the NASA Magazine aritcle 'How it Feels to be a Human Test Subject' as they prepare for a bed rest study to simulate the efects of microgravity on the human body.

  8. Mammary gland development and response to prenatal atrazine exposure in the Sprague Dawley and Long-Evans rats.

    Science.gov (United States)

    Mammary gland (MG) tumor development in Sprague Dawley (SD) rats is increased by longterm dietary exposure to the chlorotriazine herbicide atrazine (ATR). ATR is proposed to cause these changes in the adult SD rat by altering hormonally-regulated estrous cyclicity. In Long-Evans...

  9. Increase in osteoclastogenesis in an obese Otsuka Long-Evans Tokushima fatty rat model.

    Science.gov (United States)

    Ootsuka, Tomoyo; Nakanishi, Atsuko; Tsukamoto, Ikuyo

    2015-09-01

    In the present study, the effects of obesity on bone metabolism were investigated using a hyperphagic and obese rat model, the Otsuka Long‑Evans Tokushima fatty (OLETF) rat, which exhibits normal glycemic control at 8 weeks of age. Body weight, food intake, fat mass, markers of bone resorption, the activities of tartrate‑resistant acid phosphatase (TRAP) and cathepsin K, the number of osteoclasts in the proximal tibia, and the serum C‑terminal crosslinking telopeptide level were higher in OLETF rats than those in control rats (Long‑Evans Tokushima Otsuka; LETO). However, no differences in markers of bone formation, alkaline phosphatase activity, the number of osteoblasts in the proximal tibia or the serum osteocalcin level were observed. mRNA and protein levels of c‑fms, receptor for activation of nuclear factor‑κB (RANK), RANK ligand (RANKL), TRAP and cathepsin K were significantly increased in OLETF rats, although those levels of macrophage colony‑stimulating factor (M‑CSF) and osteoprotegerin (OPG) were similar to those in LETO rats. The level of serum tumor necrosis factor α (TNFα), and that of TNFα mRNA in bone, increased in association with the activation of NFκB. Furthermore, a frequency analysis and a colony formation assay respectively showed that the number of osteoclast precursors and the number of colony‑forming cells induced by M‑CSF each increased in OLETF rats compared with the control group. These results suggested that hyperphagia‑induced obesity with normal glycemic control induces the upregulation of osteoclastogenesis that is associated with an increase in the expression of c‑fms, RANK and RANKL, which is induced by TNFα, via the activation of NFκB.

  10. Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats

    Directory of Open Access Journals (Sweden)

    Lee Jung Eun

    2012-09-01

    Full Text Available Abstract Background Hyperglycemia leads to cardiac oxidative stress and an imbalance in glucose homeostasis. Diabetic cardiomyopathy is characterised by cardiac hypertrophy and fibrosis. However, the underlying mechanisms of diabetic cardiomyopathy are not fully understood. This study aimed to investigate the effects of alpha-lipoic acid (ALA on cardiac energy metabolism, antioxidant effect, and fibrosis in the hearts of Otsuka Long-Evans Tokushima fatty (OLETF rats. Methods Animals were separated into non-diabetic Long-Evans Tokushima Otsuka (LETO rats and diabetes-prone OLETF rats with or without ALA (200 mg/kg/day administration for 16 weeks. Diabetic cardiomyopathy was assessed by staining with Sirius Red. The effect of ALA on AMPK signalling, antioxidant enzymes, and fibrosis-related genes in the heart of OLETF rats were performed by Western blot analysis or immunohistochemistry. Results Western blot analysis showed that cardiac adenosine monophosphate-activated kinase (AMPK signalling was lower in OLETF rats than in LETO rats, and that ALA treatment increased the signalling in OLETF rats. Furthermore, the low antioxidant activity in OLETF rats was increased by ALA treatment. In addition to increased Sirius red staining of collagen deposits, transforming growth factor-β1 (TGF-β1 and connective tissue growth factor (CTGF were expressed at higher levels in OLETF rat hearts than in LETO rat hearts, and the levels of these factors were decreased by ALA. Conclusions ALA enhances AMPK signalling, antioxidant, and antifibrogenic effect. Theses findings suggest that ALA may have beneficial effects in the treatment of diabetic cardiomyopathy.

  11. 704-IJBCS-Article-Hien Edmond

    African Journals Online (AJOL)

    DR GATSING

    climatic zone with an annual rainfall average ... room temperature. Samples ... measured in 1: 2.5 soil/H2O volume ratio ..... municipal solid wastes inputs modified the .... Biochemistry, 19: 159-164. Qiu S, McComb AJ, Bell RW. 2008. Ratios of.

  12. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Vaateplatvorm Grand Canyoni kohal. Francis Soleri ministeeriumihoone Pariisis. Eduardo Souto de Moura projekteeritud eramu basseiniga Portugalis. Jaapani arhitekti Shinichi Ogawa ühekorruseline betoonist eramu. Britta ja Francesco Buzzi villa Itaalias. Inglise REID Arhitektuuribüroos kavandatud büroode ja lukskorteritega maja Thamesi kaldal

  13. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Soome arhitekti Sami Rintala park Lõuna-Koreas Anyang'is ja hotell Põhja-Norras Kirkenes. Prantsuse arhitekti Edouard Francois' sotsiaalmaja Normandia väikelinnas Louviers'is. Kopenhaagenis ehitati silotornid ümber korterelamuteks (Hollandi arhitektuuribüroo MVRDV koos Taani büroo JJW Arkitekteriga). Energiasäästlik büroohoone Hollandis (büroo RAU). Johnston Marklee & Associatesi projekteeritud eramu Los Angelese lähedal

  14. Viin! / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Näitused austria kaasaegsest arhitektuurist Eesti Arhitektuurimuuseumis kuni 21. V: "Viin: linnaehitus ja uusim arhitektuur" suures saalis (kuraator Leopold Dungl), kaasneb kataloog; "Elamuehitus Viinis: arhitektuur igaühele" galeriil (näituse idee: Wolfgang Förster, Dietmar Steiner, Alexandra Viehhauser, kuraator A. Viehhauser, kujundus - Span-Arhitektid: Matias del Campo, Sandra Manninger, Sebastian Michalski)

  15. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Vaateplatvorm Grand Canyoni kohal. Francis Soleri ministeeriumihoone Pariisis. Eduardo Souto de Moura projekteeritud eramu basseiniga Portugalis. Jaapani arhitekti Shinichi Ogawa ühekorruseline betoonist eramu. Britta ja Francesco Buzzi villa Itaalias. Inglise REID Arhitektuuribüroos kavandatud büroode ja lukskorteritega maja Thamesi kaldal

  16. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Sardiinia Kunstimuuseum (Zaha Hadid), kortermaja Madridis (German de Sol), kunstimuuseum Riiga (Rem Koolhaas ja Reinier de Graaf), Tietgeni ühiselamu Kopenhaagenis (arhitektuuribüroo Lundgaard&Tranberg), büroohoone Baselis (Herzog&Meuron), eramu Washingtoni osariigis

  17. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Chiba Manabu surfajate rannamaja Tokyo lähedal, Fausto Forni ja Stefano Gueli eramu Šveitsi mägedes, Daniel Libeskindi Denveri muuseumi laiendus (arhitekt Gio Ponti), automuuseumitest, NU Arhitektuuriateljee kavandatud bürooga elamu Hollandis, Arhitektuuribüroo Cukrowicz Nachbaur Architekten projekteeritud kortermaja väljanägemisega kahepereelamu Saksamaal

  18. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Sardiinia Kunstimuuseum (Zaha Hadid), kortermaja Madridis (German de Sol), kunstimuuseum Riiga (Rem Koolhaas ja Reinier de Graaf), Tietgeni ühiselamu Kopenhaagenis (arhitektuuribüroo Lundgaard&Tranberg), büroohoone Baselis (Herzog&Meuron), eramu Washingtoni osariigis

  19. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Austria büroo Coop Himmelb(l)au projekteeritud eramu, mis mõjub skulpturaalse vormina (sisekujundus Virginia Moedelt), uus raamatukoguhoone Prahas, mille projekteeris Jan Kaplicky, juurdeehitus vanale majale Šveitsi Alpides, Sebastian Irarrazavali metallist eramu, mägimaja Bosnias ja betoonist joogikiosk Austrias (projekt Wellmann Ladingerilt), mis pakub ka ööbimisvõimalust

  20. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Mari Cucinella päikesepaneelidel töötav Pekingi uus ülikoolihoone. Arhitektuuristuudio Van der Merwe Miszewski projekteeritud eramu, mis koosneb kolmest, üksteisega risti asetsevast hooneosast, maastiku kujundaja Tarba Klitzner. Hiroaki Ohtani ribimaja 34 m2 suurusel krundil Kobes. AB Verstas Arkkitehdit Oy projekteeritud lahtise vahekäiguga saun. Gernot Hertli kuupjas eramaja romantilises Austria vanalinnas Waidhofen an der Ybbs. Pekka Mäki suvevilla Turu saarestiku kaljusel rannikul

  1. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Elamurajoon Witbrant (Jacq de Brouwer, Erna van Sambeek) Tilburgis Lõuna-Hollandis. Kaubakonteineritest kokkuopandav reisimuuseum (Shigeru Ban). Säästlik, kerge, transporditav ja vähese materjalikuluga näidismaja (Richard Horden, saksa AB Haack + Höpfner). Ristikujuline maja (Bevk Perovic Arhitektid) Ljubljanas. Onnist inspireeritud pargikeskus (Chris Thurlbourne) Taani Rahvuspargis. Eestile ja muuseumidele pühendatud Soome arhitektuuriajakirja Arkkitehti 2006. a. 3. numbrist. Autoritest nimetatud Jorma Mukala, Pekka Vapaavuori, Leonhard Lapin, Triin Ojari, Tarja Nurmi (retsensioon Karin Hallas-Murula raamatule "Soome-Eesti : sajand arhitektuurisuhted)

  2. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Klaasist müramüür ja autosalong Hollandis (arhit. büroo ONL). Elamuarhitektuur Pariisi eeslinnades (arh. Marini ja Trottini). Kasutatud paneelidest ökoeramud Saksamaal (arh. Herve Biele ja insener Claus Asam). Eramud Austria ja Jaapanis. Automuuseum Stuttgardis (arh.Ben van Berkel ja Caroline Bos). USA arhitekti Lorcan O'Herlihy rannamaja. Plastfassaad Hamburgis

  3. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    1928. aastal Stockholmis valminud linnaraamatukogule kavandatud juurdeehituse konkursist. Melbourne'i ökobüroo, arhitekt Mick Pearce. Kengo Kuma projekteeritud villa Tokios. Nils Holger Moormanni kavandatud kaasaskantav kuur-aiamaja

  4. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Jun Aoki projekteeritud Vuittoni glamuuripesa ja pulmakabel Tokios, Toyo Ito kaubanduskeskus Singapuris, Lorcan O'Herlihy projekteeritud Mill Valley villa San Francisco lahe ääres, Zaha Hadidi projekteeritud vinoteek Barcelonas, mis on vanast paviljonist ümber ehitatud, Dietmar Fiechtingeri projekteeritav sild ühendamaks maismaad Mont-Saint-Micheli kloostri saarega ja Cino Zucchini projekteeritud kortermajad Milano tööstuspiirkonda

  5. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Eramu Jaapanis (arh. büroo TNA Arhitektid) ja Itaalias (arh. Massimo Curzi). Elektrijaama territooriumi ümberplaneerimine Soomes Hanasaaris. Berliini Spandau linnaossa rajatud lasteaed "Pipi paradiis" (arh. büroo Baupiloten). Restoran Inglismaal Littlehamptoni rannikul (arh. Thomas Heatherwick ja Jane Wood)

  6. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Trossidega majale kinnitatud rippuv tuba (autor Stefan Eberstadt); disainikooli hoone Saksamaa tööstuspiirkonnas (arhitektid Kazuyo Sejima ja Ryue Nishizawa); hiidlille kujuline elamu Hollandis (arhitektid Ben Huygen ja Jasper Jägers); Fuji mäe kujuline eramu Jaapanis (arhitekt Yuko Nagayama); AR Arhitektuuriauhinnad noorele arhitektile; laeva ja püramiidi hübriidi vormiga elamu (arhitekt Katsuhiro Miyamoto)

  7. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Jackson Clements Borrowsi projekteeritud eramu Melbourne'is. Dominic Stevensi eramu Iirimaal. Büroo Soeters Van Eldonki kortermajad Amsterdamis. Le Corbusier' visandatud kirik Prantsusmaal Firminy-Vert'is. Ameerika arhitektuuribüroo Morphosis projekteeritud Phare Tower Pariisis

  8. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Chiba Manabu surfajate rannamaja Tokyo lähedal, Fausto Forni ja Stefano Gueli eramu Šveitsi mägedes, Daniel Libeskindi Denveri muuseumi laiendus (arhitekt Gio Ponti), automuuseumitest, NU Arhitektuuriateljee kavandatud bürooga elamu Hollandis, Arhitektuuribüroo Cukrowicz Nachbaur Architekten projekteeritud kortermaja väljanägemisega kahepereelamu Saksamaal

  9. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Itaalia arhitekti Raimondo Guidacci kortermajad Orsara di Puglias. Paadikujuline eramu Jaapanis. Saksa arhitekti Titus Bernhardi projekteeritud eramu Augsburgis. Hamburgi Hafencity projektist. Suvepaviljon Londoni Hyde Park'is. Pilvelõhkujad Tiranas

  10. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Mario Garzaniti korrusmaja Brüsselis, Ryue Nishizawa kortermaja Tokyos, Hamburgi arhitektuuribüroo Blauraum loomingust, Michael P. Johnsoni eramu Phoenixis, jaapani arhitekti Kei'ichi Irie ja Power Unit Studio loodud monoliitbetoonist eramu Chita linnas, hollandi arhitektuuribüroo OMA loomingust, inglise büroo Peter Barber Architects lahendus Londoni ühe eeslinna kvartalile

  11. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Stirlingi preemia Enric Mirallesele. Soome puitkirikutest. Sotsiaalmajad Sloveenias. Santa Caterina turuhoone Barcelonas. Ujuv maja Hollandis. Kalju küljes rippuv maja Jaapanis. Eesti arhitektuurist kataloogis "Emerging Identities - East" ja tšehhi ajakirjas "Stauba" 2005, nr. 6 Triin Ojari ajalooline ülevaade

  12. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Richard Rogersi Madridi lennujaam, prantsuse arhitektide odavad mudelmajad, jaapani arhitektide lükandseintega eramu nn. räästamaja, Saksamaal korraldatud multifunktsionaalsete ühiselamu/hostelitubade arhitektuurikonkursi tulemustest, arhitekt Carme Pinose kontorihoone Torre Cube Mehhikos, Sean Godselli projekteeritud eramu Austraalias, arhitektuuribüroo Alphaville projekteeritud eramu Jaapanis, Stefan Hauseri (kunstnikunimega Placed To Ride) projekteeritud Malmö rulapark

  13. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Radikaalne kortermaja Itaalias Bolzanos, kus terrassid ja korteri vahelduvad fassaadil ja lähevad sujuvalt üksteiseks üle. Pouya Khazaeli Parsa projekteeritud villa Teherani lähedal, mis valminud Le Corbusier' loomingu eeskujul. Bitumi ja Pekka Manneri ülimoodne avalik tualett Suomenlinnas. Wolfgang Feyferliki ja Susi Fritzeri projekteeritud eramu, mis sobitub edukalt tammede vahele. Mätaskatusega pargipaviljon Lääne-Holsteinis. Šveitsi Alpidesse projekteeritud elamiskompleks, kus leitud vanaeuroopalik tasakaal vana ja uue vahel

  14. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Itaalia arhitekti Raimondo Guidacci kortermajad Orsara di Puglias. Paadikujuline eramu Jaapanis. Saksa arhitekti Titus Bernhardi projekteeritud eramu Augsburgis. Hamburgi Hafencity projektist. Suvepaviljon Londoni Hyde Park'is. Pilvelõhkujad Tiranas

  15. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Mario Garzaniti korrusmaja Brüsselis, Ryue Nishizawa kortermaja Tokyos, Hamburgi arhitektuuribüroo Blauraum loomingust, Michael P. Johnsoni eramu Phoenixis, jaapani arhitekti Kei'ichi Irie ja Power Unit Studio loodud monoliitbetoonist eramu Chita linnas, hollandi arhitektuuribüroo OMA loomingust, inglise büroo Peter Barber Architects lahendus Londoni ühe eeslinna kvartalile

  16. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Jun Aoki projekteeritud Vuittoni glamuuripesa ja pulmakabel Tokios, Toyo Ito kaubanduskeskus Singapuris, Lorcan O'Herlihy projekteeritud Mill Valley villa San Francisco lahe ääres, Zaha Hadidi projekteeritud vinoteek Barcelonas, mis on vanast paviljonist ümber ehitatud, Dietmar Fiechtingeri projekteeritav sild ühendamaks maismaad Mont-Saint-Micheli kloostri saarega ja Cino Zucchini projekteeritud kortermajad Milano tööstuspiirkonda

  17. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Eramu Jaapanis (arh. büroo TNA Arhitektid) ja Itaalias (arh. Massimo Curzi). Elektrijaama territooriumi ümberplaneerimine Soomes Hanasaaris. Berliini Spandau linnaossa rajatud lasteaed "Pipi paradiis" (arh. büroo Baupiloten). Restoran Inglismaal Littlehamptoni rannikul (arh. Thomas Heatherwick ja Jane Wood)

  18. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Elamurajoon Witbrant (Jacq de Brouwer, Erna van Sambeek) Tilburgis Lõuna-Hollandis. Kaubakonteineritest kokkuopandav reisimuuseum (Shigeru Ban). Säästlik, kerge, transporditav ja vähese materjalikuluga näidismaja (Richard Horden, saksa AB Haack + Höpfner). Ristikujuline maja (Bevk Perovic Arhitektid) Ljubljanas. Onnist inspireeritud pargikeskus (Chris Thurlbourne) Taani Rahvuspargis. Eestile ja muuseumidele pühendatud Soome arhitektuuriajakirja Arkkitehti 2006. a. 3. numbrist. Autoritest nimetatud Jorma Mukala, Pekka Vapaavuori, Leonhard Lapin, Triin Ojari, Tarja Nurmi (retsensioon Karin Hallas-Murula raamatule "Soome-Eesti : sajand arhitektuurisuhted)

  19. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    1928. aastal Stockholmis valminud linnaraamatukogule kavandatud juurdeehituse konkursist. Melbourne'i ökobüroo, arhitekt Mick Pearce. Kengo Kuma projekteeritud villa Tokios. Nils Holger Moormanni kavandatud kaasaskantav kuur-aiamaja

  20. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Mari Cucinella päikesepaneelidel töötav Pekingi uus ülikoolihoone. Arhitektuuristuudio Van der Merwe Miszewski projekteeritud eramu, mis koosneb kolmest, üksteisega risti asetsevast hooneosast, maastiku kujundaja Tarba Klitzner. Hiroaki Ohtani ribimaja 34 m2 suurusel krundil Kobes. AB Verstas Arkkitehdit Oy projekteeritud lahtise vahekäiguga saun. Gernot Hertli kuupjas eramaja romantilises Austria vanalinnas Waidhofen an der Ybbs. Pekka Mäki suvevilla Turu saarestiku kaljusel rannikul

  1. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Trossidega majale kinnitatud rippuv tuba (autor Stefan Eberstadt); disainikooli hoone Saksamaa tööstuspiirkonnas (arhitektid Kazuyo Sejima ja Ryue Nishizawa); hiidlille kujuline elamu Hollandis (arhitektid Ben Huygen ja Jasper Jägers); Fuji mäe kujuline eramu Jaapanis (arhitekt Yuko Nagayama); AR Arhitektuuriauhinnad noorele arhitektile; laeva ja püramiidi hübriidi vormiga elamu (arhitekt Katsuhiro Miyamoto)

  2. Viin! / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Näitused austria kaasaegsest arhitektuurist Eesti Arhitektuurimuuseumis kuni 21. V: "Viin: linnaehitus ja uusim arhitektuur" suures saalis (kuraator Leopold Dungl), kaasneb kataloog; "Elamuehitus Viinis: arhitektuur igaühele" galeriil (näituse idee: Wolfgang Förster, Dietmar Steiner, Alexandra Viehhauser, kuraator A. Viehhauser, kujundus - Span-Arhitektid: Matias del Campo, Sandra Manninger, Sebastian Michalski)

  3. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Tate Moderni juurdeehitus Londonis, arhitektid Jacques Herzog ja Pierre de Meuron. Šveitsi arhitektuuribüroos Geninasca Delefortrie projekteeritud eramu. Konkursist Vockerode elektrijaama rekonstrueerimiseks Saksamaal. Portugali arhitekti Alvaro Leite Siza Viera projekteeritud eramu. VIP paviljon Valencias 2007. aasta purjeregatiks, arhitekt David Chipperfild. Berliini uus raudteejaama peahoone. Madridi lennujaama Barajas uus terminal, büroo Richard Rogers Partnership, võitis RIBA Stirling Prize'i

  4. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Austria büroo Coop Himmelb(l)au projekteeritud eramu, mis mõjub skulpturaalse vormina (sisekujundus Virginia Moedelt), uus raamatukoguhoone Prahas, mille projekteeris Jan Kaplicky, juurdeehitus vanale majale Šveitsi Alpides, Sebastian Irarrazavali metallist eramu, mägimaja Bosnias ja betoonist joogikiosk Austrias (projekt Wellmann Ladingerilt), mis pakub ka ööbimisvõimalust

  5. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Richard Rogersi Madridi lennujaam, prantsuse arhitektide odavad mudelmajad, jaapani arhitektide lükandseintega eramu nn. räästamaja, Saksamaal korraldatud multifunktsionaalsete ühiselamu/hostelitubade arhitektuurikonkursi tulemustest, arhitekt Carme Pinose kontorihoone Torre Cube Mehhikos, Sean Godselli projekteeritud eramu Austraalias, arhitektuuribüroo Alphaville projekteeritud eramu Jaapanis, Stefan Hauseri (kunstnikunimega Placed To Ride) projekteeritud Malmö rulapark

  6. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Klaasist müramüür ja autosalong Hollandis (arhit. büroo ONL). Elamuarhitektuur Pariisi eeslinnades (arh. Marini ja Trottini). Kasutatud paneelidest ökoeramud Saksamaal (arh. Herve Biele ja insener Claus Asam). Eramud Austria ja Jaapanis. Automuuseum Stuttgardis (arh.Ben van Berkel ja Caroline Bos). USA arhitekti Lorcan O'Herlihy rannamaja. Plastfassaad Hamburgis

  7. Mustvalge linnavilla / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2013-01-01

    Emil Urbeli ja Andrus Margi projekteeritud ning Kristiina Tuulbergi ja Jaanika Sokmani (Boreal OÜ) sisekujundusega villast Tallinnas. Kalle Pruuden on kujundanud baaripukid köögis ning sepispiirded treppidel. Aknakatted-riputussüsteemid ning padjad valmisid koostöös disainer Ange Saarega. Ehitusaeg: 2012 sügis. Elamispind: 454 m²

  8. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Jackson Clements Borrowsi projekteeritud eramu Melbourne'is. Dominic Stevensi eramu Iirimaal. Büroo Soeters Van Eldonki kortermajad Amsterdamis. Le Corbusier' visandatud kirik Prantsusmaal Firminy-Vert'is. Ameerika arhitektuuribüroo Morphosis projekteeritud Phare Tower Pariisis

  9. Alumiiniummaja / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2011-01-01

    2010. a. Tallinna merelähedasel krundil valminud eramu arhitektuursest lahendusest. Arhitektid Indrek Tiigi, Ülar Mark, Matthias Klitzsch (Urban Mark / Allianss Arhitektid), sisearhitektid Tiiu Truus, Marja Viltrop (Stuudio Truus). Projekt: 2008

  10. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Stirlingi preemia Enric Mirallesele. Soome puitkirikutest. Sotsiaalmajad Sloveenias. Santa Caterina turuhoone Barcelonas. Ujuv maja Hollandis. Kalju küljes rippuv maja Jaapanis. Eesti arhitektuurist kataloogis "Emerging Identities - East" ja tšehhi ajakirjas "Stauba" 2005, nr. 6 Triin Ojari ajalooline ülevaade

  11. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Tate Moderni juurdeehitus Londonis, arhitektid Jacques Herzog ja Pierre de Meuron. Šveitsi arhitektuuribüroos Geninasca Delefortrie projekteeritud eramu. Konkursist Vockerode elektrijaama rekonstrueerimiseks Saksamaal. Portugali arhitekti Alvaro Leite Siza Viera projekteeritud eramu. VIP paviljon Valencias 2007. aasta purjeregatiks, arhitekt David Chipperfild. Berliini uus raudteejaama peahoone. Madridi lennujaama Barajas uus terminal, büroo Richard Rogers Partnership, võitis RIBA Stirling Prize'i

  12. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Soome arhitekti Sami Rintala park Lõuna-Koreas Anyang'is ja hotell Põhja-Norras Kirkenes. Prantsuse arhitekti Edouard Francois' sotsiaalmaja Normandia väikelinnas Louviers'is. Kopenhaagenis ehitati silotornid ümber korterelamuteks (Hollandi arhitektuuribüroo MVRDV koos Taani büroo JJW Arkitekteriga). Energiasäästlik büroohoone Hollandis (büroo RAU). Johnston Marklee & Associatesi projekteeritud eramu Los Angelese lähedal

  13. Arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Radikaalne kortermaja Itaalias Bolzanos, kus terrassid ja korteri vahelduvad fassaadil ja lähevad sujuvalt üksteiseks üle. Pouya Khazaeli Parsa projekteeritud villa Teherani lähedal, mis valminud Le Corbusier' loomingu eeskujul. Bitumi ja Pekka Manneri ülimoodne avalik tualett Suomenlinnas. Wolfgang Feyferliki ja Susi Fritzeri projekteeritud eramu, mis sobitub edukalt tammede vahele. Mätaskatusega pargipaviljon Lääne-Holsteinis. Šveitsi Alpidesse projekteeritud elamiskompleks, kus leitud vanaeuroopalik tasakaal vana ja uue vahel

  14. O fantasma de Evans-Pritchard: diálogos da antropologia com a sua história The ghost of Evans-Pritchard: anthropology’s dialogues with its own history

    Directory of Open Access Journals (Sweden)

    Frederico Delgado Rosa

    2011-06-01

    Full Text Available Tomando como estudo de caso a monografia de Sharon Hutchinson sobre os nuer, o presente artigo explora os quiproquós do diálogo entre a antropologia contemporânea e os clássicos, procurando detetar certas genealogias invisíveis que remontam aos funcionalistas britânicos, e nomeadamente a Evans-Pritchard. Procede a um esbatimento de certas oposições explícitas entre o presente e o passado da antropologia, revelando que as noções clássicas perpassam de forma subterrânea o discurso daqueles que dizem rejeitá-las e que muitas das preocupações atuais já tinham expressão nas etnografias modernas. É demonstrado que as abordagens estáticas - como a de Evans-Pritchard - tinham uma componente histórica e que a antropologia social britânica teve as suas respostas teóricas e metodológicas para as transformações dos contextos africanos sob domínio colonial.Through the reading of Sharon Hutchinson’s monograph on the Nuer, this article explores the misunderstandings between contemporary anthropology and the modern classics. It tries to identify invisible genealogies that go back to the British functionalists, particularly to Evans-Pritchard, and minimizes the explicit oppositions between the present and the past of anthropology. It reveals that some classical notions are detectable in non-explicit ways among those who claim to reject them and, at the same time, that contemporary concerns have their roots in modern ethnographies. The author shows that static approaches - as the one by Evans-Pritchard on the Nuer - had a historical meaning and recalls that British social anthropology had its own theoretical and methodological answers to the transformations of African contexts under colonial rule.

  15. Challenging Expertise: Paul Feyerabend vs. Harry Collins & Robert Evans on democracy, public participation and scientific authority: Paul Feyerabend vs. Harry Collins & Robert Evans on scientific authority and public participation.

    Science.gov (United States)

    Sorgner, Helene

    2016-06-01

    This paper compares Feyerabend's arguments in Science in a Free Society to the controversial theory of expertise proposed by Harry Collins and Robert Evans as a Third Wave of Science Studies. Is the legitimacy of democratic decisions threatened by the unquestioned authority of scientific advice? Or does, on the contrary, science need protection from too much democratic participation in technical decisions? Where Feyerabend's political relativism envisions democratic society as inherently pluralist and demands equal contribution of all traditions and worldviews to public decision-making, Collins and Evans hold a conception of elective modernism, defending the reality and value of technical expertise and arguing that science deserves a privileged status in modern democracies, because scientific values are also democratic values. I will argue that Feyerabend's political relativism provides a valuable framework for the evaluation of Collins' and Evans' theory of expertise. By constructing a dialog between Feyerabend and this more recent approach in Science and Technology Studies, the aim of this article is not only to show where the two positions differ and in what way they might be reconciled, but also how Feyerabend's philosophy provides substantial input to contemporary debate.

  16. Clinical Features of Systemic Lupus Erythematosus Complicated with Evans Syndrome%系统性红斑狼疮合并 Evans 综合征临床特点

    Institute of Scientific and Technical Information of China (English)

    王来芳; 赵清; 王立; 郑文洁; 赵岩; 曾小峰; 张奉春

    2014-01-01

    目的:总结系统性红斑狼疮(systemic lupus erythematosus,SLE)合并 Evans 综合征患者的临床特点。方法回顾性分析北京协和医院2004年1月至2012年7月 SLE 合并 Evans 患者的临床表现及实验室特点及治疗和预后。结果 SLE 并发 Evans 综合征患者22例,占同期 SLE 住院患者3400例的0.65%。其中男3例,女19例,平均35.1岁(16~53岁)。22例患者中以血液系统受累[特发性血小板减少性紫癜(idiopathic thrombocytopenic purpura,ITP)或自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)]为首发表现的11例(50%),确诊 SLE 后诊断 Evans 综合征者6例,二者同时诊断的5例。SLE 并发 Evans 综合征时,患者往往有多系统受累,表现为肾脏受累13例(59.1%),皮肤黏膜受累、关节炎各9例(40.9%),神经系统受累4例(18.2%),胃肠道、肺部受累各2例等。Evans 综合征多发生于 SLE 活动期,患者平均狼疮活动指数评分(11.45±7.6)分(3~30分)。伴发其他结缔组织病5例(22.7%)。经激素联合免疫抑制剂治疗后,20例好转,2例无效者应用利妥昔单抗后好转。结论 SLE 合并 Evans 综合征罕见,发生于 SLE 多系统受累及活动期。部分患者以ITP 或 AIHA 为 SLE 首发表现,应及时筛查多种自身抗体,并定期随访密切观察,以期早期诊治。%Objective To analyze the clinical features of Evans syndrome in systemic lupus erythematosus (SLE) patients.Methods Clinical and laboratory manifestations occurring during the disease course,as well as concomitant diseases,treatment and outcomes was carefully reviewed.Results There were 22 SLE patients with Evans Syndrome accounted for 0.65% of the 3 400 hospitalized SLE patients.Nineteen were female and 3 were male,with the mean age of 35.1 year.Evans syndrome was diagnosed prior to SLE in 11 patients,after SLE in 6 patients

  17. Henri Cartier-Bresson / Walker Evans : Photographier l’Amérique (1929-1947

    Directory of Open Access Journals (Sweden)

    François Brunet

    2009-08-01

    Full Text Available Dans un mot adressé en 2001 à Peter Galassi, conservateur de la photographie au MOMA, Henri Cartier-Bresson, alors âgé de quatre-vingt-treize ans, écrivait plaisamment — mais non pas complaisamment : « If it had not been for the challenge of the work of Walker Evans, I don’t think I would have remained a fotographer » (« sans le défi constitué par le travail de Walker Evans, je ne crois pas que je serais resté fotographe ». Pour fêter le centenaire de Cartier-Bresson, c’est ce défi — plutôt ...

  18. Ovariectomized Sprague-Dawley and Long-Evans rats release prolactin differently in response to estrogen

    Energy Technology Data Exchange (ETDEWEB)

    Lawson, D.M.; Sensui, N.; Gala, R.R.

    1984-01-30

    Mature female Sprague-Dawley (SD) and Long-Evans (LE) rats were ovariectomized (OVX), and given a single sc injection of either 25 or 100 ..mu..g polyestradiol phosphate (PEP); seven days later blood samples were withdrawn at two hour intervals from 1100 to 2100 hours to detect the presence of an afternoon surge of prolactin (PRL). Other groups of OVX rats of both strains also treated with PEP were sampled before and at 2, 5, 10 and 30 min after iv administration of 1 ..mu..g synthetic thyrotropin releasing hormone (TRH). Pituitary (AP) and uterine weights were determined following sacrifice one day after TRH treatment. The AP homogenates and plasma samples were assayed for PRL by radioimmunoassay. Rats of both strains had afternoon PRL surges and in both strains the magnitude and/or duration of the surges were enhanced by the higher dose of PEP. However, within each PEP dose LE rats released significantly more PRL during the surge than did SD drats. Rats of both strains also rleased PRL in response to TRH and this response was enhanced in both strains by the higher of the two doses of PEP. These data not only show that strain differences exist in estrogen-induced or mediated PRL release in the rat but also indicate that the differences are not uniform.

  19. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.

    Science.gov (United States)

    Stepensky, Polina; Rensing-Ehl, Anne; Gather, Ruth; Revel-Vilk, Shoshana; Fischer, Ute; Nabhani, Schafiq; Beier, Fabian; Brümmendorf, Tim H; Fuchs, Sebastian; Zenke, Simon; Firat, Elke; Pessach, Vered Molho; Borkhardt, Arndt; Rakhmanov, Mirzokhid; Keller, Bärbel; Warnatz, Klaus; Eibel, Hermann; Niedermann, Gabriele; Elpeleg, Orly; Ehl, Stephan

    2015-01-29

    Autoimmune cytopenia is a frequent manifestation of primary immunodeficiencies. Two siblings presented with Evans syndrome, viral infections, and progressive leukopenia. DNA available from one patient showed a homozygous frameshift mutation in tripeptidyl peptidase II (TPP2) abolishing protein expression. TPP2 is a serine exopeptidase involved in extralysosomal peptide degradation. Its deficiency in mice activates cell death programs and premature senescence. Similar to cells from naïve, uninfected TPP2-deficient mice, patient cells showed increased major histocompatibility complex I expression and most CD8(+) T-cells had a senescent CCR7-CD127(-)CD28(-)CD57(+) phenotype with poor proliferative responses and enhanced staurosporine-induced apoptosis. T-cells showed increased expression of the effector molecules perforin and interferon-γ with high expression of the transcription factor T-bet. Age-associated B-cells with a CD21(-) CD11c(+) phenotype expressing T-bet were increased in humans and mice, combined with antinuclear antibodies. Moreover, markers of senescence were also present in human and murine TPP2-deficient fibroblasts. Telomere lengths were normal in patient fibroblasts and granulocytes, and low normal in lymphocytes, which were compatible with activation of stress-induced rather than replicative senescence programs. TPP2 deficiency is the first primary immunodeficiency linking premature immunosenescence to severe autoimmunity. Determination of senescent lymphocytes should be part of the diagnostic evaluation of children with refractory multilineage cytopenias.

  20. Reframing violence against women as a human rights violation: Evan Stark's Coercive Control.

    Science.gov (United States)

    Libal, Kathryn; Parekh, Serena

    2009-12-01

    Evan Stark claims that partner-perpetrated physical abuse and other forms of violence against women ought to be understood as a human rights violation. The authors engage Stark's rhetorically powerful political and analytical innovation by outlining one theoretical and one practical challenge to shifting the paradigm that researchers, advocates, and policy makers use to describe, explain, and remedy the harms of coercive control from misdemeanor assault to human rights violation. The theoretical challenge involves overcoming the public/ private dichotomy that underpins liberal conceptions of human rights.The practical challenge involves using the human rights framework in the United States, given public indifference to human rights rhetoric or law, reluctance of U.S. policy makers to submit to scrutiny or justice-oriented processes under international law on issues of human rights and especially war crimes, and the consequent U.S. legacy of refusal to participate meaningfully in the international human rights process. The authors conclude that employing a human rights framework holds potential in the United States, but the paradigm shift Stark advocates will not materialize without widespread mobilization of interest in and understanding of human rights among domestic violence advocates and the society in general.

  1. Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).

    Science.gov (United States)

    Teachey, David T; Manno, Catherine S; Axsom, Kelly M; Andrews, Timothy; Choi, John K; Greenbaum, Barbara H; McMann, Joseph M; Sullivan, Kathleen E; Travis, Susan F; Grupp, Stephan A

    2005-03-15

    Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of disrupted lymphocyte homeostasis. Clinical manifestations of ALPS vary but typically include autoimmune cytopenias, organomegaly, lymphadenopathy, and increased risk of malignancies. A similar spectrum of symptoms may be seen in some patients with Evans syndrome (ES), a hematologic disorder defined by autoimmune destruction of at least 2 hematologic cell types. We hypothesized that a subset of patients diagnosed with ES may have ALPS. We screened 12 children with ES by flow cytometric analysis for CD4-/CD8- (double negative) T cells (DNTs) and with the definitive test for ALPS, defective in vitro Fas-mediated apoptosis. Six of the patients had elevated DNTs, suggestive of ALPS and also had defective Fas-mediated apoptosis. The other 6 patients displayed normal T-cell apoptosis; 5 of whom had normal DNTs, and 1 had a borderline result. Thus, 7 (58%) of 12 patients with ES had elevated DNTs suggestive of ALPS, with functional confirmation in 6 of 7. This suggests that analysis of DNTs may be a sensitive first-line screening test, serving as a marker of patients who should undergo definitive testing for ALPS. Our data further suggest that a number of patients with ES may have ALPS, a novel finding with important therapeutic implications.

  2. Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats.

    Science.gov (United States)

    Solanki, Naimesh; Atrooz, Fatin; Asghar, Saman; Salim, Samina

    2016-01-26

    Earlier, we reported that elevated anxiety-like behavior and high aggression in aged retired breeder Long-Evans (L-E) rats was associated with increased plasma corticosterone and elevated oxidative stress levels. In the present study, we examined how this aged aggressive and anxious rat strain responds to acute sleep deprivation (24h) and whether their behaviors can be modulated via antioxidant tempol treatment. Four groups of L-E rats were utilized: naïve control (NC), tempol treated control (T+NC), sleep deprived (SD), tempol treated and sleep deprived (T+SD). Thus, two groups were treated with tempol (1mM in drinking water for 2 weeks) while the other two were not. Two groups were subjected to acute sleep deprivation (24h) using the columns-in-water model while the other two were not. Sleep deprivation induced anxiety-like behavior, led to significant depression-like behavior and short-term memory impairment in SD rats. And, decision-making behavior also was compromised in SD rats. These behavioral and cognitive impairments were prevented with tempol treatment in T+SD rats. Tempol treatment also reduced SD-induced increase in corticosterone and oxidative stress levels in T+SD rats. These results suggest potential involvement of oxidative stress mechanisms in regulation of sleep deprivation induced behavioral and cognitive deficits in male aged-aggressive rats.

  3. Obesity in the Otsuka Long Evans Tokushima Fatty Rat: Mechanisms and Discoveries

    Directory of Open Access Journals (Sweden)

    Sheng Bi

    2016-07-01

    Full Text Available Understanding the neural systems underlying the controls of energy balance has been greatly advanced by identifying the deficits and underlying mechanisms in rodent obesity models. The current review focuses on the Otsuka Long Evans Tokushima Fatty (OLETF rat obesity model. Since its recognition in the 1990’s significant progress has been made in identifying the causes and consequences of obesity in this model. Fundamental is a deficit in the cholecystokinin (CCK 1 receptor gene resulting in the absence of CCK 1 receptors in both the gastrointestinal track and the brain. OLETF rats have a deficit in their ability to limit the size of meals and in contrast to CCK1 receptor knock-out mice, do not compensate for this increase in the size of their spontaneous meals, resulting in hyperphagia. Prior to becoming obese and in response to pair feeding, OLETF rats have increased expression of neuropeptide Y (NPY in the compact region of the dorsomedial hypothalamus (DMH and this over-expression contributes to their overall hyperphaigia. Study of the OLETF rats has revealed important differences in the organization of the DMH in rats and mice and elucidated previously unappreciated roles for DMH NPY in energy balance and glucose homeostasis.

  4. [Relapse of autoimmune hemolytic anemia in Evans syndrome after thymectomy for pure red cell aplasia].

    Science.gov (United States)

    Higuchi, Masakazu; Osaki, Koichi; Yamano, Yujiro

    2007-06-01

    A 81-year-old woman was referred to our hospital with pure red cell aplasia (PRCA) associated with a thymoma in May 2005. She had previously suffered from Evans syndrome which had been improved by prednisolone in 1999. She underwent a thymectomy, however her anemia subsequently got worse. Reticulocytopenia was noted and a marrow erythroid series was aplastic. Furthermore, both direct and indirect Coombs tests were positive, and the serum haptoglobin level was low. Based on these findings, the patient was diagnosed as having PRCA complicated with relapsed autoimmune hemolytic anemia (AIHA). The PRCA and AIHA were successfully treated with prednisolone and cyclosporine. To our knowledge, only one case of the PRCA complicated with AIHA after thymectomy has been reported. FoxP3 positive regulatory T-cells (Treg), which maintain immunological self-tolerance, were readily detectable in the excised thymoma. Thus, thymectomy resulted in removal of the Treg pool and might explain the autoimmune activation, believed to be one of the mechanisms of the post-thymectomy recurrence of the AIHA in this case.

  5. Evans syndrome in children. Long-term outcome in a prospective French national observational cohort.

    Directory of Open Access Journals (Sweden)

    Nathalie eAladjidi

    2015-09-01

    Full Text Available Evans syndrome (ES is a rare autoimmune disorder whose long-term follow-up characteristics are unknown. Patients under 18 at the time of diagnosis of a first autoimmune cytopenia have been included since 2004 in a national prospective observational cohort. In 2014, 156 children diagnosed between 1981 and 2014 with ES, were analyzed. The median age at initial cytopenia was 5.4 (0.2-17.2 years old. For 85 sequential cases, the median delay between the episodes of AIHA and ITP was 2.4 years (0.1–16.3. The median follow-up since ES diagnosis was 6.5 years (0.1-28.8. ES revealed underlying diseases in 10% of children; in 60% of patients, various associated immune manifestations were observed, and ES remained primary in 30%. Five-year ITP and AIHA relapse-free survival were respectively 25% and 61%. In all, 69% of children required one or more than one second-line immune treatment and 15 patients (10% died at a median age of 14.3 years (1.7-28.1.This national work provides the first consistent clinical description for ES and underscores the high percentage of associated immune manifestations, the long-term complications, and treatment toxicities. Current challenges include the identification of underlying genetic immune dysregulations and better characterization of subgroups of patients and of second-line therapy strategies.

  6. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model.

    Science.gov (United States)

    Manaenko, Anatol; Chen, Hank; Kammer, Jerome; Zhang, John H; Tang, Jiping

    2011-02-15

    Intracerebral hemorrhage is one of the most devastating subtypes of stroke, leaving survivors with severe neurological deficits. Disruption of the blood brain barrier (BBB) following hemorrhage results in the development of vasogenic brain edema, a most life-threatening event after such events as intracerebral hemorrhage (ICH). The Evans Blue assay is a popular method for the quantification of BBB disruption. Although this method is in common use, there are several protocols of the assay in the literature which vary in the route of administration, as well as the circulation time of the stain. In this study, we compared the amounts of accumulated stain in brain tissue following intraperitoneal versus intravenous injection at 0.5, 3 and 24h of circulation time. 58 CD-1 mice were used. Animals were divided into ICH (N=42), sham groups (N=6) and naïve (N=10). ICH animals received stereotactic injection of collagenase type VII into the right basal ganglia. Sham animals received only needle trauma. Evans Blue stain was injected 24h after collagenase injection or needle trauma. The consistency of ICH produced was characterized by estimation of hematoma volume via hemoglobin assay and neurological evaluation. The produced hematoma and neurological deficits were well comparable between different experimental groups. There was no statistically significant difference in the results of the Evans Blue assay with regard to administration route. The amount of Evans Blue stain accumulated in the brains of mice after ICH produced by collagenase injection was independent of the stain administration route. © 2010 Elsevier B.V. All rights reserved.

  7. Evans Blue fluorescence permits the rapid visualization of non-intact cells in the perilesional rim of cold-injured rat brain

    National Research Council Canada - National Science Library

    Rákos, Gabriella; Kis, Zsolt; Nagy, Dávid; Lür, György; Farkas, Tamás; Hortobágyi, Tibor; Vécsei, László; Toldi, József

    2007-01-01

    .... The early membrane dysfunction allows extravasated serum proteins to enter the injured cells, which can be readily visualized if the plasma albumin was previously bound to fluorescent tracers, such as Evans Blue (EB...

  8. Advances on treatment of Evans syndrome%Evans综合征治疗的研究进展

    Institute of Scientific and Technical Information of China (English)

    朱立平

    2012-01-01

    Evans综合征是一种少见的自身免疫性疾病,其临床表现主要为不同程度的出血、溶血.治疗分为一线、二线和三线治疗,即糖皮质激素、免疫球蛋白;免疫抑制剂、脾切除术;干细胞移植、罗米司亭等.难治性Evans综合征是治疗难点,研究发现联合应用免疫抑制剂和干细胞移植对其治疗有效.该文就Evans综合征治疗研究进展作一综述.%Evans syndrome is a rare autoimmune disease.Clinical presentation are the different degrees of bleeding and hemolysis,similar to immune thrombocytopenia and autoimmune hemolytic anemia.The treatments are divided into first-line therapy,second-line therapy and third-line therapy,including corticosteroids,intravenous immunoglobulin; immunosuppressive agents,splenectomy; haemopoietic stem cell transplantation,romiplostim and so on.The treatment of refractory Evans syndrome is difficult.Immunosuppressive agents and haemopoietic stem cell transplantation are effective.This review focuses on recent developments in the treatment of Evans syndrome.

  9. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease.

    Science.gov (United States)

    Li, Y; Togashi, Y; Sato, S; Emoto, T; Kang, J H; Takeichi, N; Kobayashi, H; Kojima, Y; Une, Y; Uchino, J

    1991-05-01

    Long-Evans Cinnamon (LEC) rats, an inbred strain of a mutant rat isolated from Long-Evans rats, develop hereditary hepatitis. To elucidate the role of copper metabolism in the development of the hepatitis in LEC rats, we examined the copper concentration in the tissues and serum levels of copper and ceruloplasmin. Copper concentration in the liver of LEC rats was over 40 times that of normal Long-Evans Agouti (LEA) rats, while the serum ceruloplasmin and copper concentrations in LEC rats decreased significantly. The hepatocytes of LEC rats show steatosis in cytoplasm and pleomorphism of mitochondria, resembling the histologic features of the liver in Wilson's disease. These findings suggest that the hereditary hepatitis in LEC rats is closely associated with copper toxicity, and may be dealing with a rat form of Wilson's disease. Thus the LEC rats will provide a unique and useful animal model for clarifying the mechanism and for developing treatment strategies for Wilson's disease and other abnormal copper metabolism in humans.

  10. Evans blue as a simple method to discriminate mosquitoes' feeding choice on small laboratory animals.

    Science.gov (United States)

    Maciel, Ceres; Fujita, André; Gueroni, Daniele I; Ramos, Anderson D; Capurro, Margareth L; Sá-Nunes, Anderson

    2014-01-01

    Temperature, humidity, vision, and particularly odor, are external cues that play essential roles to mosquito blood feeding and oviposition. Entomological and behavioral studies employ well-established methods to evaluate mosquito attraction or repellency and to identify the source of the blood meal. Despite the efficacy of such methods, the costs involved in the production or acquisition of all parts, components and the chemical reagents involved are unaffordable for most researchers from poor countries. Thus, a simple and relatively low-cost method capable of evaluating mosquito preferences and the blood volume ingested is desirable. By using Evans blue (EB) vital dye and few standard laboratory supplies, we developed and validated a system capable of evaluating mosquito's choice between two different host sources of blood. EB-injected and PBS-injected mice submitted to a number of situations were placed side by side on the top of a rounded recipient covered with tulle fabric and containing Aedes aegypti mosquitoes. Homogenates from engorged mosquitoes clearly revealed the blood source (EB- or PBS-injected host), either visually or spectrometrically. This method was able to estimate the number of engorded mosquitoes, the volume of blood ingested, the efficacy of a commercial repellent and the attractant effects of black color and human sweat. Despite the obvious limitations due to its simplicity and to the dependence of a live source of blood, the present method can be used to assess a number of host variables (diet, aging, immunity, etc) and optimized for several aspects of mosquito blood feeding and vector-host interactions. Thus, it is proposed as an alternative to field studies, and it could be used for initial screenings of chemical compound candidates for repellents or attractants, since it replicates natural conditions of exposure to mosquitoes in a laboratory environment.

  11. Evans Blue as a Simple Method to Discriminate Mosquitoes’ Feeding Choice on Small Laboratory Animals

    Science.gov (United States)

    Maciel, Ceres; Fujita, André; Gueroni, Daniele I.; Ramos, Anderson D.; Capurro, Margareth L.; Sá-Nunes, Anderson

    2014-01-01

    Background Temperature, humidity, vision, and particularly odor, are external cues that play essential roles to mosquito blood feeding and oviposition. Entomological and behavioral studies employ well-established methods to evaluate mosquito attraction or repellency and to identify the source of the blood meal. Despite the efficacy of such methods, the costs involved in the production or acquisition of all parts, components and the chemical reagents involved are unaffordable for most researchers from poor countries. Thus, a simple and relatively low-cost method capable of evaluating mosquito preferences and the blood volume ingested is desirable. Principal Findings By using Evans blue (EB) vital dye and few standard laboratory supplies, we developed and validated a system capable of evaluating mosquito’s choice between two different host sources of blood. EB-injected and PBS-injected mice submitted to a number of situations were placed side by side on the top of a rounded recipient covered with tulle fabric and containing Aedes aegypti mosquitoes. Homogenates from engorged mosquitoes clearly revealed the blood source (EB- or PBS-injected host), either visually or spectrometrically. This method was able to estimate the number of engorded mosquitoes, the volume of blood ingested, the efficacy of a commercial repellent and the attractant effects of black color and human sweat. Significance Despite the obvious limitations due to its simplicity and to the dependence of a live source of blood, the present method can be used to assess a number of host variables (diet, aging, immunity, etc) and optimized for several aspects of mosquito blood feeding and vector-host interactions. Thus, it is proposed as an alternative to field studies, and it could be used for initial screenings of chemical compound candidates for repellents or attractants, since it replicates natural conditions of exposure to mosquitoes in a laboratory environment. PMID:25333369

  12. "Nice guys finish last": influence of mate choice on reproductive success in Long-Evans rats.

    Science.gov (United States)

    Winland, C; Bolton, J L; Ford, B; Jampana, S; Tinker, J; Frohardt, R J; Guarraci, F A; Zewail-Foote, M

    2012-02-01

    The present study was designed to determine if male physiology and male reproductive behavior predict reproductive success in Long-Evans rats. Mating behavior was observed in sexually naïve, naturally cycling female rats during behavioral estrous that were given the opportunity to mate with two males simultaneously. DNA analysis of offspring born following these mating encounters was used to identify the paternity of each pup. In order to assess the effect of mate choice during these mating encounters on reproductive success, one male rat in each pair was categorized as the preferred mate if the female spent more time (>50%) with him during the mating test of the present study. Furthermore, each male in the pairs was categorized as "attractive" or "non-attractive" by computing the number of females that preferred each male across many mating tests. Similar to results reported in Lovell et al. (2007), during 76% of these mating tests the same male rat in each pair was preferred by different female rats. Overall attractiveness of individual male rats predicted reproductive success in the present study. Interestingly, "attractive" males sired significantly FEWER pups than "non-attractive" males. Neither behavioral (e.g., latency to first sexual stimulation, number of sexual stimulations) nor physiological measures (e.g., body weight, urinary testosterone levels) of male rats predicted their reproductive success. In conclusion, the present results indicate that certain features of some males are more attractive to females, but attractive males are at a reproductive disadvantage (as measured by the number of pups sired). Although basal urinary testosterone levels did not differ between males that sired the majority of pups in a litter and males that sired few or none of the pups in a litter, aggression and/or other physiological measures of fertility (e.g., penile reflexes) may differ between males that are attractive to females and those that have a reproductive

  13. [Overgrowth and DNA synthesis of neuroepithelium in embryonic stages of induced Long-Evans rat myeloschisis].

    Science.gov (United States)

    Chono, Y

    1993-01-01

    Overgrowth of the myeloschisis, namely the excessive amount of the neural plate tissue, has been reported in the human myeloschisis. However, it is still debatable how the overgrowth develops and whether the overgrowth is the cause, or the secondary effect of spinal dysraphism. The author induced myeloschisis in the fetuses of Long-Evans rats by the administration of ethylenethiourea (ETU) to pregnant rats on day 10 of gestation. The fetuses were removed 1 hour after the treatment with bromodeoxyuridine (BrdU) to the dams on day 14 and 21. The fetuses were fixed in alcohol and embedded in paraffin. H-E staining and the immunohistologic examination were performed on the staining patterns to anti-neurofilament (NFP), anti-glial fibrillary acidic protein (GFAP) and anti-BrdU antibody by ABC method. On day 14, the lateral portion of everted neural plate showed a loose arrangement of cells and there was rosette formation in the mesoderm. On day 21, cell necrosis was observed at the dorsolateral portion of myeloschisis, although the ventral portion showed almost normal cytoarchitecture and was positive to NFP and GFAP. The cause of myeloschisis in this model is supposed to be the local and direct cytotoxic effect of ETU to neuro-ectodermal junction. On day 14, control animals contained few BrdU-incorporated cells at the basal plate of neural tube. In contrast, everted neural plate showed an active uptake of BrdU diffusely in the subependymal matrix layer cells. Overgrowth was not yet identified. On day 21, overgrowth of myeloschisis was found in spite of a few positive cells to BrdU which was identical to the control animals. These findings seem to suggest that cells in the myeloschisis retain their ability of DNA synthesis for longer periods of development and overgrowth found on day 21 is possibly a secondary effect of spinal dysraphism in this model.

  14. Evans blue as a simple method to discriminate mosquitoes' feeding choice on small laboratory animals.

    Directory of Open Access Journals (Sweden)

    Ceres Maciel

    Full Text Available BACKGROUND: Temperature, humidity, vision, and particularly odor, are external cues that play essential roles to mosquito blood feeding and oviposition. Entomological and behavioral studies employ well-established methods to evaluate mosquito attraction or repellency and to identify the source of the blood meal. Despite the efficacy of such methods, the costs involved in the production or acquisition of all parts, components and the chemical reagents involved are unaffordable for most researchers from poor countries. Thus, a simple and relatively low-cost method capable of evaluating mosquito preferences and the blood volume ingested is desirable. PRINCIPAL FINDINGS: By using Evans blue (EB vital dye and few standard laboratory supplies, we developed and validated a system capable of evaluating mosquito's choice between two different host sources of blood. EB-injected and PBS-injected mice submitted to a number of situations were placed side by side on the top of a rounded recipient covered with tulle fabric and containing Aedes aegypti mosquitoes. Homogenates from engorged mosquitoes clearly revealed the blood source (EB- or PBS-injected host, either visually or spectrometrically. This method was able to estimate the number of engorded mosquitoes, the volume of blood ingested, the efficacy of a commercial repellent and the attractant effects of black color and human sweat. SIGNIFICANCE: Despite the obvious limitations due to its simplicity and to the dependence of a live source of blood, the present method can be used to assess a number of host variables (diet, aging, immunity, etc and optimized for several aspects of mosquito blood feeding and vector-host interactions. Thus, it is proposed as an alternative to field studies, and it could be used for initial screenings of chemical compound candidates for repellents or attractants, since it replicates natural conditions of exposure to mosquitoes in a laboratory environment.

  15. Methylphenidate alters flash-evoked potentials, body temperature, and behavior in Long-Evans rats.

    Science.gov (United States)

    Hetzler, Bruce E; Meckel, Katherine R; Stickle, Bruce A

    2014-01-01

    This experiment examined the effects of methylphenidate hydrochloride on flash-evoked potentials (FEPs) recorded from the visual cortex (VC) and superior colliculus (SC) of chronically implanted male Long-Evans rats, as well as on body temperature and open field behavior. FEPs were recorded at 10, 20 and 40 min following intraperitoneal injections of saline, and of doses of 0.7, 2.9, and 11.6 mg/kg methylphenidate on separate days. The 0.7 mg/kg dose did not produce significant effects. In the VC, following administration of the 11.6 mg/kg dose of methylphenidate the amplitude of components P83, N146, and P232 decreased, the amplitude of component N64 briefly increased and components P23, N30, N40, and P48 were unchanged in amplitude. In the SC, component P29 was unaffected, while components P38 and N51 were reduced in amplitude by the 11.6 mg/kg dose of methylphenidate. Peak latencies of components N40, P48, P83, and N146 in the VC and component P38 in the SC were increased by the 11.6 mg/kg dose of methylphenidate. When body temperature was recorded 45 min after drug administration, a mild dose-dependent hypothermia was found with the 2.9 and 11.6 mg/kg methylphenidate doses, suggesting that this may have contributed to the increased latencies. In subsequent open field observations, both line crossings and rearings were significantly increased by the 11.6 mg/kg dose. Increased movement into the center of the testing area was also observed, which could be a sign of increased exploration and reduced anxiety following methylphenidate.

  16. Metallothionein and antioxidant enzymes in Long-Evans Cinnamon rats treated with zinc.

    Science.gov (United States)

    Medici, Valentina; Santon, Alessandro; Sturniolo, Giacomo Carlo; D'Incà, Renata; Giannetto, Sabrina; Albergoni, Vincenzo; Irato, Paola

    2002-09-01

    The Long-Evans Cinnamon (LEC) rat is a mutant animal model for Wilson's disease. It is known that an abnormal accumulation of Cu and Fe in the liver and low concentrations of both ceruloplasmin and Cu in the serum occur in these rats. The accumulation of Cu is explained by the defective expression of the Cu-transporting P-type ATPase gene, homologous to the gene for Wilson's disease (ATP7B). The aim of this work was to clarify the action mechanism of Zn, and to verify the role that this metal plays in LEC rats in short-term treatment experiments (1 and 2 weeks) on concentrations of Cu, Zn, Fe, metallothionein (MT), 8-hydroxy-2'-deoxyguanosine (oh(8)dG) and on the activity of antioxidant enzymes. It is well known that Zn induces MT and has the ability to prevent redox-active metals, Cu and Fe, binding to and causing oxidative damage at active sites of Zn metalloenzymes and nonspecific binding sites on proteins. Zn administration reduces Cu and Fe transport from mucosal to serosal intestinal sides through competitive mechanisms. Our findings show that treatment with zinc acetate increases tissue Zn and MT contents and decreases Cu and Fe concentrations in the liver and kidneys, even if hepatic Zn and MT concentrations decrease with treatment period. Induction of MT synthesis by Zn contributes to the reduction in free radicals produced by Cu and Fe. We also observed that the superoxide dismutase (SOD)activity in liver decreases with treatment duration in association with the Cu and Fe liver decrease. However, the SOD activity in kidney increases in untreated rats at 2 weeks relative to those untreated for 1 week.

  17. Mechanisms contributing to the regional haemodynamic effects of neurotensin in conscious, unrestrained Long Evans rats.

    Science.gov (United States)

    Bachelard, H; Gardiner, S M; Kemp, P A; Bennett, T

    1992-01-01

    1. The regional haemodynamic effects of i.v. bolus doses of neurotensin (10-1000 ng) were assessed in conscious, unrestrained Long Evans rats chronically instrumented with miniaturized, pulsed Doppler probes. 2. Neurotensin caused increases in blood pressure, together with dose-related tachycardias and constrictions in the renal, superior mesenteric and hindquarters vascular beds. The tachycardia elicited by the 1000 ng dose of neurotensin was preceded by a transient bradycardia. 3. In the presence of phentolamine, the pressor effect of neurotensin (1000 ng) was converted into a hypotensive effect, accompanied by reduced tachycardic and constrictor responses in the renal, superior mesenteric and hindquarters vascular beds. The tachycardia was not preceded by a bradycardia. 4. In the presence of phentolamine and propranolol, the pressor and bradycardic responses to neurotensin were unaffected, whereas the tachycardia was abolished. The renal vasconstrictor effect was smaller, while the constrictions in the superior mesenteric and hindquarters vascular beds were not different from those in untreated rats. 5. In rats neonatally treated with capsaicin (50 mg kg-1, s.c.), the pressor effects elicited by neurotensin (300 and 1000 ng) were reduced as were the constrictor responses in the renal (at the dose of 300 ng), superior mesenteric (at the dose of 300 ng) and hindquarters (at both doses) vascular beds. The bradycardia elicited by neurotensin (1000 ng) was absent, whereas the tachycardia was potentiated. 6. The results indicate that in conscious, intact rats neurotensin appears to exert cardiovascular influences through activation of sympathoadrenal mechanisms and also through non-adrenergic effects on the heart, renal, superior mesenteric and hindquarters vascular beds. The latter effects appear to involve capsaicin-sensitive nerves.

  18. Dietary isoflavones alter regulatory behaviors, metabolic hormones and neuroendocrine function in Long-Evans male rats

    Directory of Open Access Journals (Sweden)

    Bu Lihong

    2004-12-01

    Full Text Available Abstract Background Phytoestrogens derived from soy foods (or isoflavones have received prevalent usage due to their 'health benefits' of decreasing: a age-related diseases, b hormone-dependent cancers and c postmenopausal symptoms. However, little is known about the influence of dietary phytoestrogens on regulatory behaviors, such as food and water intake, metabolic hormones and neuroendocrine parameters. This study examined important hormonal and metabolic health issues by testing the hypotheses that dietary soy-derived isoflavones influence: 1 body weight and adipose deposition, 2 food and water intake, 3 metabolic hormones (i.e., leptin, insulin, T3 and glucose levels, 4 brain neuropeptide Y (NPY levels, 5 heat production [in brown adipose tissue (BAT quantifying uncoupling protein (UCP-1 mRNA levels] and 6 core body temperature. Methods This was accomplished by conducting longitudinal studies where male Long-Evans rats were exposed (from conception to time of testing or tissue collection to a diet rich in isoflavones (at 600 micrograms/gram of diet or 600 ppm vs. a diet low in isoflavones (at approximately 10–15 micrograms/gram of diet or 10–15 ppm. Body, white adipose tissue and food intake were measured in grams and water intake in milliliters. The hormones (leptin, insulin, T3, glucose and NPY were quantified by radioimmunoassays (RIA. BAT UCP-1 mRNA levels were quantified by PCR and polyacrylamide gel electrophoresis while core body temperatures were recorded by radio telemetry. The data were tested by analysis of variance (ANOVA (or where appropriate by repeated measures. Results Body and adipose tissue weights were decreased in Phyto-600 vs. Phyto-free fed rats. Food and water intake was greater in Phyto-600 animals, that displayed higher hypothalamic (NPY concentrations, but lower plasma leptin and insulin levels, vs. Phyto-free fed males. Higher thyroid levels (and a tendency for higher glucose levels and increased uncoupling

  19. Ethanol seeking by Long Evans rats is not always a goal-directed behavior.

    Directory of Open Access Journals (Sweden)

    Regina A Mangieri

    Full Text Available BACKGROUND: Two parallel and interacting processes are said to underlie animal behavior, whereby learning and performance of a behavior is at first via conscious and deliberate (goal-directed processes, but after initial acquisition, the behavior can become automatic and stimulus-elicited (habitual. With respect to instrumental behaviors, animal learning studies suggest that the duration of training and the action-outcome contingency are two factors involved in the emergence of habitual seeking of "natural" reinforcers (e.g., sweet solutions, food or sucrose pellets. To rigorously test whether behaviors reinforced by abused substances such as ethanol, in particular, similarly become habitual was the primary aim of this study. METHODOLOGY/PRINCIPAL FINDINGS: Male Long Evans rats underwent extended or limited operant lever press training with 10% sucrose/10% ethanol (10S10E reinforcement (variable interval (VI or (VR ratio schedule of reinforcement, or with 10% sucrose (10S reinforcement (VI schedule only. Once training and pretesting were complete, the impact of outcome devaluation on operant behavior was evaluated after lithium chloride injections were paired with the reinforcer, or unpaired 24 hours later. After limited, but not extended instrumental training, lever pressing by groups trained under VR with 10S10E and under VI with 10S was sensitive to outcome devaluation. In contrast, responding by both the extended and limited training 10S10E VI groups was not sensitive to ethanol devaluation during the test for habitual behavior. CONCLUSIONS/SIGNIFICANCE: Operant behavior by rats trained to self-administer an ethanol-sucrose solution showed variable sensitivity to a change in the value of ethanol, with relative insensitivity developing sooner in animals that received time-variable ethanol reinforcement during training sessions. One important implication, with respect to substance abuse in humans, is that initial learning about the

  20. Dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model

    Institute of Scientific and Technical Information of China (English)

    Ramsi Siaj; Vanessa Sauer; Sandra St(o)ppeler; Hans-Ullrich Spiegel; Gabriele K(o)hler; Andree Zibert

    2012-01-01

    To investigate the impact of dietary copper given at different time paints on the onset of fulminant hepatitis.METHODS:The Long-Evans cinnamon (LEC) rat model of Wilson's disease (WD) was used to study the impact of high dietary copper (hCu) on the induction of fulminant hepatitis at early or late time points of life.High Cu diet was started in rat pups or in adults (month5) for three months.Animals that received reduced dietary copper (rCu) throughout their lifetime served as a control.Hepatitis-associated serum markers (alanine aminotransferase,aspartate transaminase,bilirubin)were analyzed in animal groups receiving hCu or rCu.Liver copper content and liver histology were revealed at sacrifice.A set of 5 marker genes previously found to be affected in injured liver and which are related to angiogenesis (Vegfa),fat metabolism (Srebf1),extracellular matrix (Timp1),oxidative stress (Hmox1),and the cell cycle (Cdkn1a) were analyzed by real-time polymerase chain reaction.RESULTS:Regardless of the time point when hCu wasstarted,LEC rats (35/36) developed fulminant hepatitis and died.Animals receiving rCu (36/36) remained healthy,did not develop hepatitis,and survived long term without symptoms of overt disease,although liver copper accumulated in adult animals (477 ± 75 lg/g).With regard to start of hCu,onset of fulminant hepatitis was significantly (P < 0.001) earlier in adults (35 ± 9d)that showed pre-accumulation of liver copper as compared to the pup group (77 ± 15 d).Hepatitis-associated serum markers,liver copper and liver histology,as well as gene expression,were affected in LEC rats receiving hCu.However,except for early and rapid onset of hepatitis,biochemical and molecular markers were similar at the early and late time points of disease.CONCLUSION:Rapid onset of fulminant hepatitis in asymptomatic LEC rats with elevated liver copper suggests that there is a critical threshold of liver copper which is important to trigger the course of WD.

  1. Vitamin B12 and ketorolac on pain in Long Evans rats

    Directory of Open Access Journals (Sweden)

    Mizanur Rahman

    2016-12-01

    Full Text Available Background: Effects of vitamin B12 on pain have been demonstrated in different animal and humanstudies. But comparison of these effects with similar effects of ketorolac tromethamine (KT and theircombination have not been established. Objective: To assess the effects of vitamin B12 on pain andalso to compare them with those of the combinations of vitamin B12 with KT in rat models. Methods:This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh MujibMedical University (BSMMU, Dhaka, from March 2015 to February 2016. For this, 20 (twentyLong Evans rats (215±35 gm of both sexes were divided into control (A, with 5 ml/kg normal salineand experimental (B1, with 15 mg/kg B12; B2, with 10 mg/kg KT; B3, with B12+KT groups with 5rats in each group. All the drugs and vitamin were administered intraperitoneally in a single dose justone hour before formalin test. To evaluate the treatments’ effect on nociceptive pain, early phase (1st-5th minutes; on central analgesic system, interphase (6th-15th minutes; and on inflammatory pain,late phase (16th-60th minutes of the formalin test, were observed. In all phases, total frequency ofjerking and total duration of flexing and licking of the right hind paw were counted after administrationof subcutaneous formalin (50 μl, 2.5% injection. Statistical analysis was done by ANOVA, followedby Bonferroni post hoc test. In the interpretation of results, p≤0.05 was considered as significant.Results: B12 lowered only the jerking frequency and KT lowered both jerking frequency and flexinglicking duration significantly (p≤0.001 in the late phase of formalin test. On the other hand, combinationof B12 and KT significantly (p≤0.001 lowered both the study variables in all 3 phases of formalintest. Conclusion: From this study it may be concluded that, vitamin B12 possess analgesic effects andcombination of B12 with KT is more effective than those of their individual administration.

  2. Modeling Ethanol Decomposition on Transition Metals: A Combined Application of Scaling and Bronsted-Evans-Polanyi Relations

    DEFF Research Database (Denmark)

    Ferrin, P.; Simonetti, D.; Kandoi, S.

    2009-01-01

    calculations necessary to describe trends in activity and selectivity across metal and alloy surfaces, thus extending the reach of DFT to more complex systems. In-this work, the well-known family of Bronsted-Evans-Polanyi (BEP) correlations, connecting minima with maxima in the potential energy surface...... on a subset of these surfaces are calculated. Experiments on supported catalysts verify that this simple model is reasonably accurate in describing reactivity trends across metals, suggesting that the combination of BEP and scaling relations may substantially reduce the cost of DFT calculations required...

  3. Changes in plasma glucose in Otsuka Long-Evans Tokushima Fatty rats after oral administration of maple syrup.

    Science.gov (United States)

    Nagai, Noriaki; Yamamoto, Tetsushi; Tanabe, Wataru; Ito, Yoshimasa; Kurabuchi, Satoshi; Mitamura, Kuniko; Taga, Atsushi

    2015-01-01

    We investigate whether maple syrup is a suitable sweetener in the management of type 2 diabetes using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The enhancement in plasma glucose (PG) and glucose absorption in the small intestine were lower after the oral administration of maple syrup than after sucrose administration in OLETF rats, and no significant differences were observed in insulin levels. These data suggested that maple syrup might inhibit the absorption of glucose from the small intestine and preventing the enhancement of PG in OLETF rats. Therefore, maple syrup might help in the prevention of type 2 diabetes.

  4. Hesperiidae of Rondônia, Brazil: Cephise Evans (Pyrginae), with descriptions of new species from Mexico and Brazil

    OpenAIRE

    Austin,George T; Mielke,Olaf H.H.

    2000-01-01

    The species of Cephise Evans, 1953 are divided in two groups: "cephise" group (hind wing without long tails) and "procerus" group (hind wing with long tails). In the "cephise" group the following species are included: Cephise cephise (Herrich-Schäffer, 1869) with his synonyms Thymele hydarnes Mabille, syn.n., Eudamus zopyrus Plötz, 1881, Telennades injuncta Plötz, 1882, nom. nud., Eudamus maneros Mabille, 1883, syn.n., Nascus orima Schaus, 1902, syn.n., Nascus orita Schaus, 1902; Cephise impu...

  5. Evans syndrome and antibody deficiency: an atypical presentation of chromosome 22q11.2 deletion syndrome

    Directory of Open Access Journals (Sweden)

    Gloria Colarusso

    2010-06-01

    Full Text Available We report a case of an 8-year-old male patient with Evans syndrome and severe hypogammaglobulinemia, subsequently in whom the 22q11.2 deletion syndrome (22q11.2 DS was diagnosed. No other clinical sign of 22q11.2 DS was present with the exception of slight facial dysmorphism. The case is of particular interest because it suggests the need to research chromosome 22q11.2 deletion in patients who present with autoimmune cytopenia and peculiar facial abnormalities, which could be an atypical presentation of an incomplete form of 22q11.2 DS.

  6. Evans syndrome and antibody deficiency: an atypical presentation of chromosome 22q11.2 deletion syndrome.

    Science.gov (United States)

    Colarusso, Gloria; Gambineri, Eleonora; Lapi, Elisabetta; Casini, Tommaso; Tucci, Fabio; Lippi, Francesca; Azzari, Chiara

    2010-09-06

    We report a case of an 8-year-old male patient with Evans syndrome and severe hypogammaglobulinemia, subsequently in whom the 22q11.2 deletion syndrome (22q11.2 DS) was diagnosed. No other clinical sign of 22q11.2 DS was present with the exception of slight facial dysmorphism. The case is of particular interest because it suggests the need to research chromosome 22q11.2 deletion in patients who present with autoimmune cytopenia and peculiar facial abnormalities, which could be an atypical presentation of an incomplete form of 22q11.2 DS.

  7. S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism.

    Science.gov (United States)

    Takemura, Shigekazu; Minamiyama, Yukiko; Kodai, Shintaro; Shinkawa, Hiroji; Tsukioka, Takuma; Okada, Shigeru; Azuma, Hideki; Kubo, Shoji

    2013-09-01

    It is important to prevent and improve diabetes mellitus and its complications in a safe and low-cost manner. S-Allyl cysteine, an aged garlic extract with antioxidant activity, was investigated to determine whether S-allyl cysteine can improve type 2 diabetes in Otsuka Long-Evans Tokushima Fatty rats with nonalcoholic fatty liver disease. Male Otsuka Long-Evans Tokushima Fatty rats and age-matched Long-Evans Tokushima Otsuka rats were used and were divided into two groups at 29 weeks of age. S-Allyl cysteine (0.45% diet) was administered to rats for 13 weeks. Rats were killed at 43 weeks of age, and detailed analyses were performed. S-Allyl cysteine improved hemoglobinA1c, blood glucose, triglyceride, and low-density lipoprotein cholesterol levels. Furthermore, S-allyl cysteine normalized plasma insulin levels. S-Allyl cysteine activated the mRNA and protein expression of both peroxisome proliferator-activated receptor α and γ, as well as inhibiting pyruvate dehydrogenase kinase 4 in Otsuka Long-Evans Tokushima Fatty rat liver. Sterol regulatory element-binding protein 1c and forkhead box O1 proteins were normalized by S-allyl cysteine in Otsuka Long-Evans Tokushima Fatty rat liver. In conclusions, these findings support the hypothesis that S-allyl cysteine has diabetic and nonalcoholic fatty liver disease therapeutic potential as a potent regulating agent against lipogenesis and glucose metabolism.

  8. Contemporary perspectives on psychosomatics in Germany: A commentary on Karen Gubb's paper, "Psychosomatics today: a review of contemporary theory and practice".

    Science.gov (United States)

    Frommer, Jörg

    2013-02-01

    Karen Gubb's (2013) review focuses on contemporary developments in psychoanalytic theory and practice in relation to psychosomatics, starting with some historical remarks, and Paris School with the Attachment approach. This paper examines the question of how the German scene fits into the issues raised in Gubb's discussion. From a historical point of view, psychosomatic thinking had already come into existence at the beginning of the twentieth century in internal medicine, influenced not only by Freud's ideas, but also by holistic philosophical approaches, anthropology, and semiotic systems theory as well. Psychosomatics is still under the influence of psychodynamic thinking, but as a required subject for all medical students, it is currently more involved in inpatient treatment settings than in psychoanalyses in the classical couch setting. Research projects using standardized questionnaires, neuroimaging, and other empirical methods have also proved that these treatments are as effective as therapy based on psychoanalytic concepts like alexithymia or the Attachment approach. In addition, qualitative methods have been implemented to grasp the fine-grained conscious and unconscious processes in the inner life of patients and in the verbal and nonverbal interaction phenomena of therapies. To sum up: Recent developments in psychoanalytic theory, which begin to overcome the differences among psychoanalytic schools in favor of re-erecting a common psychoanalytic understanding like that demonstrated in Gubb's article, fit together in bridging the gap between insights from classical psychoanalyses and results from empirical research.

  9. The Junkyard in the Jungle: Transnational, Transnatural Nature in Karen Tei Yamashita’s Through the Arc of the Rain Forest

    Directory of Open Access Journals (Sweden)

    Begoña Simal

    2010-03-01

    Full Text Available In this new millennium the relatively young field of ecocriticism has had to face important transdisciplinary, transnational, and transnatural challenges. This article attempts to demonstrate how two of the major changes that environmental criticism is currently undergoing, the transnational turn and the transnatural challenge, have both been encoded in Through the Arc of the Rain Forest (1990, the first novel published by Karen Tei Yamashita. I particularly focus on a significant episode in Through the Arc of the Rain Forest, when a peculiar anthropogenic ecosystem is discovered, and interpret it according to Leo Marx’s classic paradigm of “the machine in the garden.” I intend to prove that Yamashita’s novel not only revisits the old master theory but also revamps it by destabilizing the classic human-nature divide inherent in first-wave ecocriticism and by adding the transnational ingredient. Thus, the machine-in-the-garden paradigm is updated in order to incorporate the broadening of current environmental criticism, both literally (globalization and conceptually (transnatural nature. While at times Marx’s paradigm may metamorphose in intriguing ways, the old trope also corroborates its continuing validity. Though filtered by the sieve of globalization and shaken by the emergence of cyborg ecosystems, “the machine in the garden” has survived as a compelling ecocritical framework, even if it occasionally mutates into a junkyard in the jungle.

  10. The Junkyard in the Jungle: Transnational, Transnatural Nature in Karen Tei Yamashita’s Through the Arc of the Rain Forest

    Directory of Open Access Journals (Sweden)

    Begoña Simal

    2010-03-01

    Full Text Available

    In this new millennium the relatively young field of ecocriticism has had to face important transdisciplinary, transnational, and transnatural challenges. This article attempts to demonstrate how two of the major changes that environmental criticism is currently undergoing, the transnational turn and the transnatural challenge, have both been encoded in Through the Arc of the Rain Forest (1990, the first novel published by Karen Tei Yamashita. I particularly focus on a significant episode in Through the Arc of the Rain Forest, when a peculiar anthropogenic ecosystem is discovered, and interpret it according to Leo Marx’s classic paradigm of “the machine in the garden.” I intend to prove that Yamashita’s novel not only revisits the old master theory but also revamps it by destabilizing the classic human-nature divide inherent in first-wave ecocriticism and by adding the transnational ingredient. Thus, the machine-in-the-garden paradigm is updated in order to incorporate the broadening of current environmental criticism, both literally (globalization and conceptually (transnatural nature. While at times Marx’s paradigm may metamorphose in intriguing ways, the old trope also corroborates its continuing validity. Though filtered by the sieve of globalization and shaken by the emergence of cyborg ecosystems, “the machine in the garden” has survived as a compelling ecocritical framework, even if it occasionally mutates into a junkyard in the jungle.

  11. Effects of Moderate Alcohol Intake in the Bladder of the Otsuka Long Evans Tokushima Fatty Diabetic Rats.

    Science.gov (United States)

    Bae, Woong Jin; Choi, Yong Sun; Kim, Su Jin; Cho, Hyuk Jin; Hong, Sung Hoo; Kim, Sae Woong; Hwang, Tae-Kon; Kim, Dai Jin; Lee, Ji Youl

    2015-09-01

    Diabetes is related with a number of cystopathic complications. However, there have been no studies about the influence of alcohol consumption in the bladder of type 2 diabetes. Thus, we investigated the effect of moderate alcohol intake in the bladder of the Otsuka Long Evans Tokushima Fatty (OLETF) diabetic rat. The non-diabetic Long-Evans Tokushima Otsuka (LETO, n=14) and the OLETF control group (n=14) were fed an isocaloric diet; the LETO (n=14) and the OLETF ethanol group (n=14) were fed 36% ethanol 7 g/kg/day. After ten weeks, muscarinic receptors, RhoGEFs, myogenic change, and the level of oxidative stress were evaluated. Moderate alcohol intake significantly decreased excessive muscarinic receptor and Rho kinase expressions in the OLETF rats compared with the LETO rats. In addition, iNOS and collagen expression were not changed in the OLETF rats in spite of alcohol consumption. Superoxide dismutase levels, which is involved in antioxidant defense, in the LETO rats were significantly decreased after alcohol consumption, however those in the OLETF rats were similar. Moderate alcohol consumption reduces the oxidative stress, and may prevent molecular and pathologic changes of the bladder of rats with type 2 diabetes.

  12. Troglitazone prevented the development of fatty liver under obese and diabetic condition in Otsuka Long-Evans Tokushima fatty rats

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We aimed to clarify the effects of troglitazone to prevent the development of fatty liver in Otsuka Long-Evans Tokushima fatty (OLETF) rats, an obese type2 diabetes model. Treatment of 0.2% troglitazone for 16 weeks significantly decreased blood glucose, serum insulin and free fatty acid (FFA) concentration (P<0.05 for each) in the OLETF rats leaving their food intake, body weight and general fat pad weight unaffected compared with those of their lean littermates, Long-Evans Tokushima Otsuka (LETO) rats. Troglitazone restored increase in liver weight and hepatic triglyceride(TG) content of the OLETF rats (P<0.05 for each). These findings were accertained by histological examination which showed that fat deposition, necrosis and vacuolization of hepatocyte, markers for fatty liver, were diminished by troglitazone treatment. Messenger RNA expression of microsomal triglyceride transfer protein in the liver, a marker for hepatic TG output, was not significantly different between OLETF and LETO rats with or without troglitazone treatment. Fatty acid composition such as C18∶1(oleic acid) showed no remarkable change after troglitazone treatment in OLETF rats, indicating no dietary influence to hepatic lipogenesis. These indicate that reduction in circulating FFA level may be one of the main mechanisms for troglitazone to prevent the development of insulin resistance and fatty liver.

  13. Absence of diurnal variation in visceromotor response to colorectal distention in normal Long Evans rats [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Sara Botschuijver

    2016-01-01

    Full Text Available Background: Enhanced colorectal sensitivity (i.e. visceral hypersensitivity is thought to be a pathophysiological mechanism in irritable bowel syndrome (IBS. In healthy men a circadian variation in rectal perception to colonic distention was described. Disturbed day and night rhythms, which occur in shift work and trans meridian flights, are associated with the prevalence of IBS. This raises the question whether disruptions of circadian control are responsible for the observed pathology in IBS. Prior to investigating altered rhythmicity in relation to visceral hypersensitivity in a rat model for IBS, it is relevant to establish whether normal rats display circadian variation similar to healthy men.  Methodology and findings: In rodents colorectal distension leads to reproducible contractions of abdominal musculature. We used quantification of this so called visceromotor response (VMR by electromyography (EMG to assess visceral sensitivity in rats. We assessed the VMR in normal male Long Evans rats at different time points of the light/dark cycle. Although a control experiment with male maternal separated rats confirmed that intentionally inflicted (i.e. stress induced changes in VMR can be detected, normal male Long Evans rats showed no variation in VMR along the light/dark cycle in response to colorectal distension. Conclusions: In the absence of a daily rhythm of colorectal sensitivity in normal control rats it is not possible to investigate possible aberrancies in our rat model for IBS.

  14. Mechanism of enhanced lipid peroxidation in the liver of Long-Evans cinnamon (LEC) rats.

    Science.gov (United States)

    Yamamoto, H; Hirose, K; Hayasaki, Y; Masuda, M; Kazusaka, A; Fujita, S

    1999-11-01

    The Long-Evans Cinnamon (LEC) rat is a mutant strain of rats that accumulate copper (Cu) in the liver in much the same way as individuals who suffer from Wilson's disease (WD) and has been suggested as a model for this disease. Lipid peroxidation (LPO) is considered to be involved in the toxic action of Cu in the livers of LEC rats. We investigated the mechanism of LPO in the livers of LEC rats showing apparent signs of hepatitis. Several-fold higher LPO levels were observed in post-mitochondrial supernatant (S-9) fraction of livers from hepatitic LEC rats than in those from Wistar rats. To mimic living cells, we introduced NADPH-generating system (NADPH-gs) into the S-9 incubation system. Thus was ensured a constant supply of NADPH to vital enzymes that may be directly or indirectly involved in the generation and/or elimination of reactive oxygen species (ROSs), such as glutathione reductase (GSSG-R), which require NADPH for their reactions. The levels of LPO in liver S-9 from hepatitic LEC rats were further increased by incubating liver S-9 at 37 degrees C in the presence of NADPH-gs. This increase was inhibited by EDTA, butylated hydroxytoluene (BHT), and catalase (CAT), suggesting that some metal, most likely the accumulated Cu, and ROSs derived from hydrogen peroxide (H2O2) are involved in the increased levels of LPO in the livers of hepatitic LEC rats. The requirement of NADPH-gs for enhanced LPO in the livers of hepatitic LEC rats indicates the consumption of NADPH during reactions leading to LPO. It is known that H2O2, and consequently hydroxyl radical are generated during Cu-catalyzed glutathione (GSH) oxidation. The cyclic regeneration of GSH from GSSG by NADPH-dependent GSSG-R in the presence of NADPH-gs may cause sustained generation of hydroxyl radical in the presence of excess free Cu. The generation of H2O2 in S-9 fraction of livers from hepatitic LEC rats was observed to be significantly higher than that in S-9 fraction of livers from non

  15. Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats.

    Science.gov (United States)

    Lin, Lung-Chang; Juan, Chun-Ting; Chang, Hsueh-Wen; Chiang, Ching-Tai; Wei, Ruey-Chang; Lee, Mei-Wen; Mok, Hin-Kiu; Yang, Rei-Cheng

    2013-05-01

    Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n=5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±12.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. OTSUKA-LONG-EVANS-TOKUSHIMA FATTY 糖尿病大鼠周围神经的结构蛋白改变%STRUCTURAL PROTEIN ALTERATIONS IN PERIPHERAL NERVE OF OTSUKA-LONG-EVANS-TOKUSHIMA FATTY DIABETIC RATS

    Institute of Scientific and Technical Information of China (English)

    李建萍; 吕传真

    2004-01-01

    为了解Otsuka-Long Evans-Tokushima Fatty(OLETF)糖尿病大鼠周围神经的结构蛋白改变,使用OLETF大鼠10只/Long Evans-Tokushima Otsuka(LETO对照大鼠6只,于糖尿病发病后6个月取坐骨神经,制成冰冻切片和单纤维贴片,进行神经结构蛋白的免疫组织化学染色.在光镜下观察到OLETF大鼠周围神经部分区域有结构异常.轴索结构中,Ranvier结区的钠离子通道蛋白密度降低并向结旁区移位,近结旁段的钾离子通道蛋白(Kv1.1)向Ranvier结区和节间段弥散,神经丝着色浅淡且不均匀.髓鞘结构中,结旁段的髓鞘相关糖蛋白着色不均匀并向节间段弥散,致密髓鞘层的髓鞘碱性蛋白和Schwann细胞表面的半乳糖脑苷脂基本正常.上述结果提示Ranvier结区的轴膜和结旁段的髓鞘是OLETF糖尿病大鼠周围神经的起始损害位点.

  17. Review of Financial Intelligence for Entrepreneurs: What You Really Need to Know about the Numbers by Karen Berman and Joe Knight, with John Case

    Directory of Open Access Journals (Sweden)

    H.L. Vacher

    2014-01-01

    Full Text Available Berman, Karen and Knight, Joe, with John Case. Financial Intelligence for Entrepreneurs: What You Really Need to Know about the Numbers, (Boston MA: Harvard Business Press, 2008. 285 pp. ISBN 978-1-4221-1915-0. From “The art of finance (and why it matters” (Part One through “Creating a financially intelligent company” (Part Eight, Financial Intelligence for Entrepreneurs is an engaging explanation and appreciation of financial statements and financial ratios. Short, easily digested chapters; just-in-time boxes to introduce terminology; easy, direct, in-text calculations from bare-bones, hypothetical financial statements to illustrate concepts; a 44-page appendix of crafted exercises on the income statement, balance sheet, cash-flow statement, and financial ratios from two public companies for deeper understanding; a detailed 19-page index for quick, after-you’ve-read-it navigation – all make for an efficient learning opportunity for readers who want a painless way to know about the numbers used in the world of business. Two quantitative literacy principles emerge as themes. The first is the “art of finance” (social construction: that is, the numbers are not totally objective; to varying extents, they reflect decisions, assumptions, and estimates in the accounting. The second is that ratios provide a window into the story that financial statements are able to tell. Written for entrepreneurs and company owners, the book ends with OBM (open-book management—a management philosophy based on financial literacy. The vision of this book is businesses in which all employees are financially literate and managers and owners are financially intelligent.

  18. Myths and verities in protein folding theories: From Frank and Evans iceberg-conjecture to explanation of the hydrophobic effect

    Science.gov (United States)

    Ben-Naim, Arieh

    2013-10-01

    Starting from the seminal article by Frank and Evans where the "iceberg formation" idea was first expressed, we follow the evolution of this idea to the explanation of the hydrophobic effect. We show that the idea of iceberg formation can provide an explanation to the entropy, and enthalpy of solvation of non-polar solutes in water, provided one first explains why a simple non-polar solute would form icebergs in the first place. Having done that, the questions regarding the outstanding large hydrophobic solvation Gibbs energy remains unexplained. This conclusion follows from the exact entropy-enthalpy-compensation pertaining to any structural changes induced in the solvent. We also comment on some misinterpretation of the partial molar heat capacity of non-polar solutes in water.

  19. Autoimmune hepatitis-primary biliary cirrhosis overlap syndrome concomitant with immune hemolytic anemia and immune thrombocytopenic purpura (Evans syndrome).

    Science.gov (United States)

    Korkmaz, Huseyin; Bugdaci, Mehmet Sait; Temel, Tuncer; Dagli, Mehmet; Karabagli, Pinar

    2013-04-01

    Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) associated with Evans syndrome; combination of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) has rarely been reported. We report the case of a 53-year-old patient who presented with weakness, myalgia, arthralgia, shortness of breath and purpura. Initial laboratory investigations revealed liver dysfunction, anemia and thrombocytopenia. Anti-nuclear (ANA) and antimitochondrial M2 (AMA M2) antibodies were positive. Diagnose of PBC-AIH overlap was made by clinical, serological and histological investigations. AIHA and ITP was identified with clinical-laboratory findings and bone marrow puncture. She was treated with IVIG followed by prednisolone and ursodeoxycholic acid. Hemoglobin-thrombocytes increased rapidly and transaminases improved at day 8. We have reported the first case in the literature with AIH-PBC overlap syndrome concurrent by ITP and AIHA which suggest the presence of shared genetic susceptibility factors in multiple autoimmune conditions including AIH, PBC, ITP and AIHA.

  20. Dermatomiositis y síndrome de evans asociado a infección por HTLV-1

    Directory of Open Access Journals (Sweden)

    David Loja-Oropeza

    2016-01-01

    Full Text Available Paciente mujer de 55 años de edad, natural de Ayacucho, con antecedente de dermatomiositis desde hace 3 años, recibió tratamiento irregular con prednisona. Dos meses antes del ingreso presenta anemia hemolítica autoinmune y púrpura trombocitopénica idiopática, recibió pulsos de metilprednisolona y transfusión de paquetes globulares. Al ingreso, soporosa, mal estado general, marcada pérdida ponderal, deshidratada, livedo reticularis en miembros inferiores, onicodistrofia y onicolisis múltiple en los dedos de ambos pies. Western Blot positivo para HTLV-1. Evoluciona con hipoglicemia recurrente. Reportamos un caso de dermatomiositis y síndrome de Evans presentados en el contexto de una infección por virus linfotrópico humano tipo 1.

  1. Effects of prenatal exposure to a low dose atrazine metabolite mixture onpubertal timing and prostate development of male Long-Evans rats

    Science.gov (United States)

    Atrazine (ATR) is a chlorotriazine herbicide extensively used in the US and other countries. Studies examining the effects of adult or developmental ATR exposure on the mammary gland (MG) have used either the Sprague Dawley (SD) or Long-Evans (LE) rat, but no strain comparisons h...

  2. Strain Differences in Dimethylbenz[a]anthracene-Induced Mammary Tumor Incidence in Long Evans and Sprague Dawley Rat Offspring Following Prenatal Atrazine Exposure

    Science.gov (United States)

    It has been shown that prenatal exposure to the chlorotriazine herbicide atrazine (ATR) during mammary bud outgrowth (late gestation) delays postnatal mammary epithelial progression in Long Evans (LE) rats. Our laboratory has recently found that prenatal exposure to ATR also effe...

  3. THE EFFECT OF TARGETED KNOCKOUT MUTATION ON THE TRANSCRIPTIONAL PROFILE OF THE KIDNEY IN TSC2 MUTANT LONG-EVANS (EKER) RATS.

    Science.gov (United States)

    The effect of a targeted knockout mutation on the transcriptional profile of the kidney inTsc2 mutant Long-Evans (Eker) rats. Renal cell carcinoma (RCC) is the most common tumor of the adult kidney, accounting for up to 80% of malignant renal neoplasms. Hereditary...

  4. Effects of prenatal exposure to a low dose atrazine metabolite mixture onpubertal timing and prostate development of male Long-Evans rats

    Science.gov (United States)

    Atrazine (ATR) is a chlorotriazine herbicide extensively used in the US and other countries. Studies examining the effects of adult or developmental ATR exposure on the mammary gland (MG) have used either the Sprague Dawley (SD) or Long-Evans (LE) rat, but no strain comparisons h...

  5. Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat.

    Directory of Open Access Journals (Sweden)

    Françoise Schmitt

    Full Text Available BACKGROUND: Wilson's disease (WD is an inherited disorder of copper metabolism leading to liver failure and/or neurological impairment. Its diagnosis often remains difficult even with genetic testing. Relative exchangeable copper (REC has recently been described as a reliable serum diagnostic marker for WD. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this study was to validate the use of REC in the Long Evans Cinnamon (LEC rat, an animal model for WD, and to study its relevance under different conditions in comparison with conventional markers. Two groups of LEC rats and one group of Long-Evans (LE rats were clinically and biologically monitored from 6 to 28 weeks of age. One group of LEC rats was given copper-free food. The other groups had normal food. Blood samples were collected each month and different serum markers for WD (namely ceruloplasmin oxidase activity, exchangeable copper (CuEXC, total serum copper and REC and acute liver failure (serum transaminases and bilirubinemia were tested. Every LEC rat under normal food developed acute liver failure (ALF, with 40% global mortality. Serum transaminases and bilirubinemia along with total serum copper and exchangeable copper levels increased with the onset of acute liver failure. A correlation was observed between CuEXC values and the severity of ALF. Cut-off values were different between young and adult rats and evolved because of age and/or liver failure. Only REC, with values >19%, was able to discriminate LEC groups from the LE control group at every time point in the study. REC sensitivity and specificity reached 100% in adults rats. CONCLUSIONS/SIGNIFICANCE: REC appears to be independent of demographic or clinical data in LEC rats. It is a very simple and reliable blood test for the diagnosis of copper toxicosis owing to a lack of ATP7B function. CuEXC can be used as an accurate biomarker of copper overload.

  6. Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.

    Science.gov (United States)

    Karmahapatra, Soumendra Krishna; Saha, Tapas; Adhikari, Sanjay; Woodrick, Jordan; Roy, Rabindra

    2014-03-01

    The Long-Evans Cinnamon (LEC) rat is an animal model for Wilson's disease. This animal is genetically predisposed to copper accumulation in the liver, increased oxidative stress, accumulation of DNA damage, and the spontaneous development of hepatocellular carcinoma. Thus, this animal model is useful for studying the relationship of endogenous DNA damage to spontaneous carcinogenesis. In this study, we have investigated the apurinic/apyrimidinic endonuclease 1 (APE1)-mediated excision repair of endogenous DNA damage, apurinic/apyrimidinic (AP)-sites, which is highly mutagenic and implicated in human cancer. We found that the activity was reduced in the liver extracts from the acute hepatitis period of LEC rats as compared with extracts from the age-matched Long-Evans Agouti rats. The acute hepatitis period had also a heightened oxidative stress condition as assessed by an increase in oxidized glutathione level and loss of enzyme activity of glyceraldehyde 3-phosphate dehydrogenase, a key redox-sensitive protein in cells. Interestingly, the activity reduction was not due to changes in protein expression but apparently by reversible protein oxidation as the addition of reducing agents to extracts of the liver from acute hepatitis period reactivated APE1 activity and thus, confirmed the oxidation-mediated loss of APE1 activity under increased oxidative stress. These findings show for the first time in an animal model that the repair mechanism of AP-sites is impaired by increased oxidative stress in acute hepatitis via redox regulation which contributed to the increased accumulation of mutagenic AP-sites in liver DNA.

  7. Novel "Add-On" Molecule Based on Evans Blue Confers Superior Pharmacokinetics and Transforms Drugs to Theranostic Agents.

    Science.gov (United States)

    Chen, Haojun; Jacobson, Orit; Niu, Gang; Weiss, Ido D; Kiesewetter, Dale O; Liu, Yi; Ma, Ying; Wu, Hua; Chen, Xiaoyuan

    2017-04-01

    One of the major design considerations for a drug is its pharmacokinetics in the blood. A drug with a short half-life in the blood is less available at a target organ. Such a limitation dictates treatment with either high doses or more frequent doses, both of which may increase the likelihood of undesirable side effects. To address the need for additional methods to improve the blood half-life of drugs and molecular imaging agents, we developed an "add-on" molecule that contains 3 groups: a truncated Evans blue dye molecule that binds to albumin with a low micromolar affinity and provides a prolonged half-life in the blood; a metal chelate that allows radiolabeling for imaging and radiotherapy; and maleimide for easy conjugation to drug molecules. Methods: The truncated Evans blue molecule was conjugated with the chelator NOTA or DOTA, and the resulting conjugate was denoted as NMEB or DMEB, respectively. As a proof of concept, we coupled NMEB and DMEB to c(RGDfK), which is a small cyclic arginine-glycine-aspartic acid (RGD) peptide, for targeting integrin αvβ3 NMEB and DMEB were radiolabeled with (64)Cu and (90)Y, respectively, and tested in xenograft models. Results: The resulting radiolabeled conjugates showed a prolonged circulation half-life and enhanced tumor accumulation in integrin αvβ3-expressing tumors. Tumor uptake was markedly improved over that with NOTA- or DOTA-conjugated c(RGDfK). Tumor radiotherapy experiments in mice with (90)Y-DMEB-RGD showed promising results; existing tumors were eliminated. Conclusion: Conjugation of our novel add-on molecule, NMEB or DMEB, to potential tracers or therapeutic agents improved blood half-life and tumor uptake and could transform such agents into theranostic entities. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

  8. Anti-obesity effects of granulocyte-colony stimulating factor in Otsuka-Long-Evans-Tokushima fatty rats.

    Directory of Open Access Journals (Sweden)

    Yonggu Lee

    Full Text Available Granulocyte-colony stimulating factor (G-CSF has molecular structures and intracellular signaling pathways that are similar to those of leptin and ciliary neurotropic factor (CNTF. It also has immune-modulatory properties. Given that leptin and CNTF play important roles in energy homeostasis and that obesity is an inflammatory condition in adipose tissue, we hypothesized that G-CSF could also play a role in energy homeostasis. We treated 12 38-week-old male Otsuka-Long-Evans-Tokushima fatty rats (OLETF, diabetic and 12 age-matched male Long-Evans-Tokushima rats (LETO, healthy with 200 µg/day G-CSF or saline for 5 consecutive days. Body weight reduction was greater in G-CSF-treated OLETF (G-CSF/OLETF than saline-treated OLETF (saline/OLETF following 8 weeks of treatment (-6.9±1.6% vs. -3.1±2.2%, p<0.05. G-CSF treatment had no effect on body weight in LETO or on food intake in either OLETF or LETO. Body fat in G-CSF/OLETF was more reduced than in saline/OLETF (-32.2±3.1% vs. -20.8±6.2%, p<0.05. Energy expenditure was higher in G-CSF/OLETF from 4 weeks after the treatments than in saline/OLETF. Serum levels of cholesterol, triglyceride, interleukin-6 and tumor necrosis factor-α were lower in G-CSF/OLETF than in saline/OLETF. Uncoupling protein-1 (UCP-1 expression in brown adipose tissue (BAT was higher in G-CSF/OLETF than in saline/OLETF, but was unaffected in LETO. Immunofluorescence staining and PCR results revealed that G-CSF receptors were expressed in BAT. In vitro experiments using brown adipocyte primary culture revealed that G-CSF enhanced UCP-1 expression from mature brown adipocytes via p38 mitogen-activated protein kinase pathway. In conclusion, G-CSF treatment reduced body weight and increased energy expenditure in a diabetic model, and enhanced UCP-1 expression and decreased inflammatory cytokine levels may be associated with the effects of G-CSF treatment.

  9. Tamm ja Asi / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Näitus "Sisearhitektid Väino Tamm & Vello Asi" Eesti Arhitektuurimuuseumis kuni 2. IX. Kuna valminud objektidest ei ole enam ühtegi originaalkujul alles, on eksponeeritud võimalikult suurel hulgal valmimisjärgseid fotosid, millest enamiku on teinud Rein Vainküla

  10. Tamm ja Asi / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Näitus "Sisearhitektid Väino Tamm & Vello Asi" Eesti Arhitektuurimuuseumis kuni 2. IX. Kuna valminud objektidest ei ole enam ühtegi originaalkujul alles, on eksponeeritud võimalikult suurel hulgal valmimisjärgseid fotosid, millest enamiku on teinud Rein Vainküla

  11. Uued koolid 2006 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Viimsi kool (arhitektid Illimar Truverk, Raul Järg, Priit Pent, Eero Endjärv; sisearhitektid Kristi Lents, Hannelore Pihlak), Rakvere eragümnaasiumi algklasside maja (arhitektid Laur Pihel, Tauno Aadma), Tallinna Rahumäe põhikool (arhitektid Maaja Nummert, Triinu Nurmik), Tabasalu Ühisgümnaasium (arhitekt Veljo Kaasik), Jüri gümnaasium (arhitekt Katrin Tomberg Tohter)

  12. Karen Blixen. The Devil's Advocate

    DEFF Research Database (Denmark)

    Bunch, Mads

    en række modfortællinger gør Blixen op med denne forestilling bl.a. i ”Carnival”, ”Drømmerne” og ”Ehrengard”. Ph.d.en påviser også, at Blixen allerede i 1920erne havde indgående kendskab til det meste af Kierkegaards æstetisk-pseudonyme forfatterskab (1843-46), og at den relativt ukendte...

  13. 2006. aasta arhitektuurikonkursid / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Toodud ka 2006. a. konkursside tulemused: Eesti Rahva Muuseumi uus hoone, Tartu Ida t. lastead, Kiviõli linnaväljak, Tartu Lutsu t. korterelamu fassaadilahendus, Paide spordihall, Pärnu piirivalvekordoni hoone, Tartu Rebase t. kortermajade kompleks, Viljandi Maagümnaasiumi juurdeehitus, Veneetsia X arhitektuuribiennaali Eesti kuraatorinäitus, betoonehitis 2005, Estonia Seltsi vana teatrimaja asukoha tähistamine, TTÜ uus raamatukogu, Maakri kvartali arhitektuurikonkursi I etapp, Viljandi Uku t. 1A Lidli kauplusehoone ja südalinna kvartali detailplaneering, Pärnu jõeäärse keskuse ideeplaneering, Karksi-Nuia keskväljak ja roheala, terasehitis 2006, Edela-Eesti loodus- ja keskkonnahariduskeskuse ehk ökomaja eskiisprojekt, puitehitis 2006

  14. Uued koolid 2006 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Viimsi kool (arhitektid Illimar Truverk, Raul Järg, Priit Pent, Eero Endjärv; sisearhitektid Kristi Lents, Hannelore Pihlak), Rakvere eragümnaasiumi algklasside maja (arhitektid Laur Pihel, Tauno Aadma), Tallinna Rahumäe põhikool (arhitektid Maaja Nummert, Triinu Nurmik), Tabasalu Ühisgümnaasium (arhitekt Veljo Kaasik), Jüri gümnaasium (arhitekt Katrin Tomberg Tohter)

  15. 2006. aasta arhitektuurikonkursid / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Toodud ka 2006. a. konkursside tulemused: Eesti Rahva Muuseumi uus hoone, Tartu Ida t. lastead, Kiviõli linnaväljak, Tartu Lutsu t. korterelamu fassaadilahendus, Paide spordihall, Pärnu piirivalvekordoni hoone, Tartu Rebase t. kortermajade kompleks, Viljandi Maagümnaasiumi juurdeehitus, Veneetsia X arhitektuuribiennaali Eesti kuraatorinäitus, betoonehitis 2005, Estonia Seltsi vana teatrimaja asukoha tähistamine, TTÜ uus raamatukogu, Maakri kvartali arhitektuurikonkursi I etapp, Viljandi Uku t. 1A Lidli kauplusehoone ja südalinna kvartali detailplaneering, Pärnu jõeäärse keskuse ideeplaneering, Karksi-Nuia keskväljak ja roheala, terasehitis 2006, Edela-Eesti loodus- ja keskkonnahariduskeskuse ehk ökomaja eskiisprojekt, puitehitis 2006

  16. Karen Blixen. The Devil's Advocate

    DEFF Research Database (Denmark)

    Bunch, Mads

    Denne Ph.d. er en artikel-Ph.d. og består af tre artikler, der er integreret i en længere baggrundssektion, der indeholder 1) en forskningsoversigt over Blixen Kierkegaard forskningen fra 1934 til i dag, 2) refleksioner over den teori og metode, der er anvendt i hver af artiklerne, 3) en række su...

  17. Edasiminek Afganistanis / Karen B. Decker

    Index Scriptorium Estoniae

    Decker, Karen B.

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 7. veebr. 2008, lk. 9. Afganistani kaitseministri Abdul Rahim Wardaki visiit rõhutab Eesti rolli rahvusvahelise julgeolekuabimissiooni liikmena Afganistanis

  18. Muhu majakavahi maja / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2012-01-01

    Taivo Pilleri ja Mart Haberi maakodust Muhu saarel. 1905. aastal ehitatud majakavahi maja taastati aastatel 2009-2012. Rekonstruktsiooni arhitekt Laila Põdra, sisearhitektid Taivo Piller, Mart Haber, Pille Lausmäe

  19. Muhu majakavahi maja / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2012-01-01

    Taivo Pilleri ja Mart Haberi maakodust Muhu saarel. 1905. aastal ehitatud majakavahi maja taastati aastatel 2009-2012. Rekonstruktsiooni arhitekt Laila Põdra, sisearhitektid Taivo Piller, Mart Haber, Pille Lausmäe

  20. Consumption of pork-liver protein hydrolysate reduces body fat in Otsuka Long-Evans Tokushima Fatty rats by suppressing hepatic lipogenesis.

    Science.gov (United States)

    Shimizu, Muneshige; Tanabe, Soichi; Morimatsu, Fumiki; Nagao, Koji; Yanagita, Teruyoshi; Kato, Norihisa; Nishimura, Toshihide

    2006-01-01

    This study was performed to examine the effect of consumption of pork-liver protein hydrolysate (PLH) on body fat accumulation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats as a non-insulin-dependent diabetes mellitus model and in Long-Evans Tokushima Otsuka (LETO) rats as a control. Male 20-week-old OLETF and LETO rats were pair-fed either PLH or casein containing diet for 14 weeks. In the OLETF rats, dietary PLH significantly reduced the growth and weight of fat pad including perirenal and epididymal adipose tissues. Consumption of PLH markedly suppressed hepatic activities of lipogenesis enzymes such as glucose-6-phosphate dehydrogenase and fatty acid synthase and slightly elevated fecal excretion of total fat. In the LETO rats, growth and adipose tissue weight were unaffected by dietary treatment. The results suggest that PLH is a novel ingredient suppressing body fat in genetically obese rats by reducing lipogenesis.

  1. Hyperthermia of magnetic nanoparticles allows passage of sodium fluorescein and Evans blue dye across the blood-retinal barrier.

    Science.gov (United States)

    Tabatabaei, Seyed Nasrollah; Tabatabaei, Maryam Sadat; Girouard, Hélène; Martel, Sylvain

    2016-09-01

    The blood-retina barrier (BRB) is a biological barrier consisting of tightly interconnected endothelial cells inside the retinal vascular network that protects the neural tissue from harmful pathogens and neurotoxic molecules circulating in the bloodstream. Unfortunately, with regard to retinoblastoma, this barrier also prevents systemically administered therapeutics reaching the retinal tissue. In this study we introduce a novel technique to locally and transiently increase BRB permeability for drug delivery using hyperthermia of magnetic nanoparticles (MNPs). An alternating current (AC) magnetic field was used to induce hyperthermia of locally injected MNPs in the left ophthalmic artery of a rat model. To improve adherence on the surface of the endothelium, commercially available MNPs coated with human transferrin glycoproteins were used. After hyperthermia we assessed the extravasation of systemically injected sodium fluorescein (NaF) as well as Evans blue dye (EBD) into the retinal tissue. Spectrofluorometry and fluorescent microscopy image analysis show a significant increase of dye penetration in the retina where hyperthermia of MNPs was applied. Our proposed new technique can allow both small and large dye molecules to cross the BRB. While the results are preliminary and thorough evaluation of the retinal tissue following hyperthermia is necessary, this technique has the potential to be an effective mean for the treatment of various diseases such as retinoblastoma.

  2. Ex vivo Evans blue assessment of the blood brain barrier in three breast cancer brain metastasis models.

    Science.gov (United States)

    Do, John; Foster, Deshka; Renier, Corinne; Vogel, Hannes; Rosenblum, Sahar; Doyle, Timothy C; Tse, Victor; Wapnir, Irene

    2014-02-01

    The limited entry of anticancer drugs into the central nervous system represents a special therapeutic challenge for patients with brain metastases and is primarily due to the blood brain barrier (BBB). Albumin-bound Evans blue (EB) dye is too large to cross the BBB but can grossly stain tissue blue when the BBB is disrupted. The course of tumor development and the integrity of the BBB were studied in three preclinical breast cancer brain metastasis (BCBM) models. A luciferase-transduced braintropic clone of MDA-231 cell line was used. Nude mice were subjected to stereotactic intracerebral inoculation, mammary fat pad-derived tumor fragment implantation, or carotid artery injections. EB was injected 30 min prior to euthanasia at various timepoints for each of the BCBM model animals. Serial bioluminescent imaging demonstrated exponential tumor growth in all models. Carotid BCBM appeared as diffuse multifocal cell clusters. EB aided the localization of metastases ex vivo. Tumor implants stained blue at 7 days whereas gross staining was not evident until day 14 in the stereotactic model and day 28 for the carotid model. EB assessment of the integrity of the BBB provides useful information relevant to drug testing in preclinical BCBM models.

  3. Catastrophic relapse of Evans syndrome five years after allogeneic BMT notwithstanding full donor chimerism. Terminal hemolytic-uremic syndrome.

    Science.gov (United States)

    Marmont, A M; Gualandi, F; Occhini, D; Morandi, F; Ferretti, E; Pezzolo, A; Strada, P; Ravetti, J L; Pistoia, V; Falanga, A; Bacigalupo, A

    2006-09-01

    A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic anemia recurred with rapid increase of serum bilirubin to over 50 mg%: he responded to combined therapy, but died on day +17 from admission of an acute hemolytic uremic syndrome (HUS). All circulating blood cells, including erythrocytes, were 100% donor. Ex vivo cultured and expanded T and B cells from the peripheral blood were also 100% donor. The supernatants from B cell cultures, containing either IgM or IgG, did not react with a panel of erythrocytes. Thus in this typical autoimmune disease with a predominant B cell pathogenesis the donor immune system resulted "innocent of autoimmunity". The persistence of long-lived recipient autoreactive plasma-cell lines in survival niches, still producing autoantibodies, may be hypothesized for this and similar cases. The postulated graft-versus-autoimmunity (GVA) effect was apparently not sufficient to eradicate autoimmunity in this patient.

  4. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats.

    Science.gov (United States)

    Kato, J; Kobune, M; Kohgo, Y; Sugawara, N; Hisai, H; Nakamura, T; Sakamaki, S; Sawada, N; Niitsu, Y

    1996-08-15

    Several clinical studies have suggested that excess hepatic iron accumulation is a progressive factor in some liver diseases including chronic viral hepatitis and hemochromatosis. However, it is not known whether iron-induced hepatotoxicity may be directly involved in hepatitis, cirrhosis, and liver cancer. The Long-Evans Cinnamon (LEC) rat, which accumulates excess copper in the liver as in patients with Wilson's disease, is of a mutant strain displaying spontaneous hemolysis, hepatitis, and liver cancer. We found previously that LEC rats harbored an additional abnormality: accumulation of as much iron as copper in the liver. In the present study, we compared the occurrence of hepatitis and liver cancer in LEC rats fed an iron-deficient diet (ID) with those in rats fed a regular diet (RD). The RD group showed rapid increments of hepatic iron concentrations as the result of hemolysis, characteristics of fulminant hepatitis showing apoptosis, and a 53% mortality rate. However, no rats in the ID group died of fulminant hepatitis. Hepatic iron, especially "free" iron concentration and the extent of hepatic fibrosis in the ID group were far less than those of the RD group. At week 65, all rats in the RD group developed liver cancer, whereas none did in the ID group. These results suggest that the accumulation of iron, possibly by virtue of synergistic radical formation with copper, plays an essential role in the development of fulminant hepatitis, hepatic fibrosis, and subsequent hepatocarcinogenesis in LEC rats.

  5. Barnes-Evans relations for dwarfs with an application to the determination of distances to cataclysmic variables

    CERN Document Server

    Beuermann, K

    2006-01-01

    Barnes-Evans type relations provide an empirical relationship between the surface brightness of stars and their color. They are widely used for measuring the distances to stars of known radii, as the Roche-lobe filling secondaries in cataclysmic variables (CVs). The calibration of the surface brightness of field dwarfs of near-solar metalicity with spectral types A0 to L8 covers all secondary spectral types detectable in CVs and related objects and will aid in the measurement of their distances. The calibrations are based on the radii of field dwarfs measured by the Infrared Flux Method and by interferometry. Published photometry is used and homogenized to the Cousins Rc and Ic and the CIT JHK photometric systems. The narrow band surface brightness at 7500A is based on our own and published spectrophotometry. Care is taken to select the dwarfs for near-solar metalicity, appropriate to CVs, and to avoid errors caused by unrecognized binarity. Relations are provided for the surface brightness in V, Rc, Ic, J, H...

  6. Mechanism of hepatorenal syndrome in rats of Long-Evans Cinnamon strain, an animal model of fulminant Wilson's disease.

    Science.gov (United States)

    Nomiyama, K; Nomiyama, H; Kameda, N; Tsuji, A; Sakurai, H

    1999-02-15

    Rats of Long-Evans Cinnamon (LEC) strain were used as a hepatorenal syndrome model of fulminant Wilson's disease. Copper levels in the kidneys increased markedly from 16 to 126 microg Cu/g from 12 to 16 weeks, and remained at the same level at 16 and 19 weeks when the rats suffered from severe renal dysfunction and also at 20 weeks in some other normal rats. The above findings imply that the renal dysfunction may have been induced independently of the copper level in the kidneys. The present study suggested the following mechanism: immediately after copper-induced hepatic dysfunction, plasma copper-metallothionein (CuMT), which was released from the liver, became elevated. The elevation was closely related to the increases in alkaline phosphatase, glucose and amino acids, all in the urine. The above findings suggest that plasma CuMT, which was released from the liver into the blood upon copper-induced hepatic dysfunction, was subsequently filtered at the glomeruli due to its smaller molecular weight, and then caused dysfunction of the brush border membrane of the renal proximal tubules probably after splitting into radical copper and amino acids in acidic vesicles close to the membrane. The critical concentration of plasma CuMT required to induce renal dysfunction was estimated as 1 microg Cu/l.

  7. Book Review: Evans, Arthur V. 2014. Beetles of Eastern North America. Princeton University Press, Princeton, New Jersey, U.S.A. 560 pp. ISBN 978-0-691-13304-1 (paperback). Price: US $35.00

    Science.gov (United States)

    A book review is presented for “Beetles of Eastern North America” by Arthur V. Evans. This 560 page book was published in 2014 and treats over 1,400 species of beetles distributed in eastern North America....

  8. Quantitative assessment of mammary gland development in female Long Evans rats following in utero exposure to atrazine.

    Science.gov (United States)

    Hovey, Russell C; Coder, Pragati Sawhney; Wolf, Jeffrey C; Sielken, Robert L; Tisdel, Merrill O; Breckenridge, Charles B

    2011-02-01

    In this study, we quantified the effects of in utero exposure to the herbicide atrazine on subsequent mammary gland development. Atrazine was administered to pregnant female Long Evans rats from gestation days 13-19 at doses of 0, 6.5, 50, or 100 mg/kg/day. A pair-fed control group was yoked to the high-dose atrazine-treated group. Litter size was standardized to 10 pups on postnatal day (PND) 4. Whole mounts of the left fourth mammary gland and histologic sections of the right fourth gland were obtained from a subgroup of offspring on PND1, 21, 33, on day of vaginal opening (VO), or around PND65 at diestrus. A blinded, quantitative analysis of key morphological features in mammary gland whole mounts (ductal elongation, ductal network area, epithelial area, terminal end bud [TEB] incidence, and epithelial density) as well as epithelial proliferation within different parenchymal structures was conducted. There was no effect of atrazine exposure on any of the measures of mammary gland development at the maternal dose of 6.5 mg/kg/day. On PND1, ductal elongation was increased by approximately 20% (p < 0.05) in the female offspring born to dams exposed to 50 and 100 mg/kg/day atrazine, coincident with decreased epithelial proliferation in the 100 mg/kg/day group at this age. These differences were not present on PND21, or thereafter. An increased incidence of TEB in the mammary glands from females that were born to both the pair-fed and 50 mg/kg/day-treated dams at the time of VO indicated that this response was a specific result of maternal caloric restriction. Collectively, these data indicate that maternal atrazine exposure has no long-term effects on mammary gland development in female offspring beyond a transitory response to high doses at PND1.

  9. Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats.

    Science.gov (United States)

    Morales, Melissa; McGinnis, Molly M; McCool, Brian A

    2015-12-01

    The current experiment examined the effects of 10 days of chronic intermittent ethanol (CIE) exposure on anxiety-like behavior and home cage ethanol intake using a 20% intermittent access (M, W, F) paradigm in male and female Long-Evans rats. Withdrawal from alcohol dependence contributes to relapse in humans and increases in anxiety-like behavior and voluntary ethanol consumption in preclinical models. Our laboratory has shown that 10 days of CIE exposure produces both behavioral and neurophysiological alterations associated with withdrawal in male rats; however, we have yet to examine the effects of this exposure regime on ethanol intake in females. During baseline, females consumed more ethanol than males but, unlike males, did not show escalations in intake. Rats were then exposed to CIE and were again given intermittent access to 20% ethanol. CIE males increased their intake compared to baseline, whereas air-exposed males did not. Ethanol intake in females was unaffected by CIE exposure. Notably, both sexes expressed significantly elevated withdrawal-associated anxiety-like behavior in the plus maze. Finally, rats were injected with the cannabinoid CB1 receptor antagonist, SR141716A (0, 1, 3, 10mg/kg, i.p.) which reduced ethanol intake in both sexes. However, females appear to be more sensitive to lower doses of this CB1 receptor antagonist. Our results show that females consume more ethanol than males; however, they did not escalate their intake using the intermittent access paradigm. Unlike males, CIE exposure had no effect on drinking in females. It is possible that females may be less sensitive than males to ethanol-induced increases in drinking after a short CIE exposure. Lastly, our results demonstrate that males and females may have different pharmacological sensitivities to CB1 receptor blockade on ethanol intake, at least under the current conditions.

  10. Stress facilitates late reversal learning using a touchscreen-based visual discrimination procedure in male Long Evans rats.

    Science.gov (United States)

    Bryce, Courtney A; Howland, John G

    2015-02-01

    The stress response is essential to the survival of all species as it maintains internal equilibrium and allows organisms to respond to threats in the environment. Most stress research has focused on the detrimental impacts of stress on cognition and behavior. Reversal learning, which requires a change in response strategy based on one dimension of the stimuli, is one type of behavioral flexibility that is facilitated following some brief stress procedures. The current study investigated a potential mechanism underlying this facilitation by blocking glucocorticoid receptors (GRs) during stress. Thirty-seven male Long Evans rats learned to discriminate between two images on a touchscreen, one of which was rewarded. Once a criterion was reached, rats received stress (30 min of restraint stress or no stress) and drug (GR antagonist RU38486 or vehicle) administration prior to each of the first 3 days of reversal learning. We expected that stress would facilitate reversal learning and RU38486 (10 mg/kg) would prevent this facilitation in both early (50% correct in one session) stages of reversal learning. Results showed that stressed rats performed better than unstressed rats (fewer days for late reversal, fewer correction trials, and fewer errors) in the late but not early stage of reversal learning. RU38486 did not block the facilitation of RL by stress, although it dramatically increased response, but not reward, latencies. These results confirm the facilitation of late reversal by stress in a touchscreen-based operant task in rats and further our understanding of how stress affects higher level cognitive functioning and behavior.

  11. Hesperiidae of Rondônia, Brazil: Cephise Evans (Pyrginae, with descriptions of new species from Mexico and Brazil

    Directory of Open Access Journals (Sweden)

    George T. Austin

    2000-09-01

    Full Text Available The species of Cephise Evans, 1953 are divided in two groups: "cephise" group (hind wing without long tails and "procerus" group (hind wing with long tails. In the "cephise" group the following species are included: Cephise cephise (Herrich-Schäffer, 1869 with his synonyms Thymele hydarnes Mabille, syn.n., Eudamus zopyrus Plötz, 1881, Telennades injuncta Plötz, 1882, nom. nud., Eudamus maneros Mabille, 1883, syn.n., Nascus orima Schaus, 1902, syn.n., Nascus orita Schaus, 1902; Cephise impunctus sp.n. from Rondônia, Brazil; Cephise glarus (Mabille, 1888, sp. reval.; Cephise nuspesez Burns, 1996; Cephise malesedis sp.n. from Rondônia, Brazil; Cephise maculatus sp.n. from Rondônia, Brazil; Cephise burnsi sp.n. from Espírito Santo, Brazil; Cephise mexicanus sp.n. from Oaxaca and San Luis Potosi, Mexico. In the "procerus" group are included: Cephise procerus (Plötz, 1880; Cephise aelius (Plötz, 1880 sp. reval.. comb.n.. with its synonyms Eudamus auginulus Godman & Salvin, 1893, syn.n. and Eudamus callicina Schaus, 1902, syn.n.; Cephise callias (Mabille, 1888; and Cephise guatemalaensis (Freeman, 1977. Lectotypes are designated for Eudamus cephise Herrich-Schäffer, 1869, Thymele hydarnes Mabille, 1877, Telegonus glarus Mabille, 1988, Eudamus callias Mabille, 1888, Goniurus procerus Plötz, 1888, and Goniurus aelius Plötz, 1880. Neotypes are designated for Eudamus zopyrus Plötz, 1881, and Thymele maneros Mabille, 1883. A pseudotype of Thymele hydarnes is identified, this is actually a female of Cephise impunctus sp.n. Six species of Cephise occur sympatrically in Rondônia, Brazil.

  12. Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders.

    Directory of Open Access Journals (Sweden)

    Katherine M Ku

    Full Text Available The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD, allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD and Long-Evans (LE, between the ages of postnatal day (PND 26-56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii the testing environment may profoundly influence the expression of strain-specific social behavior and (iii simple, automated measures of sociability may not capture the complexities of rat social interactions.

  13. Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders

    Science.gov (United States)

    Ku, Katherine M.; Weir, Ruth K.; Silverman, Jill L.; Berman, Robert F.; Bauman, Melissa D.

    2016-01-01

    The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD) and Long-Evans (LE), between the ages of postnatal day (PND) 26–56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i) commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii) the testing environment may profoundly influence the expression of strain-specific social behavior and (iii) simple, automated measures of sociability may not capture the complexities of rat social interactions. PMID:27351457

  14. Strain-dependent effects of acute caffeine on anxiety-related behavior in PVG/c, Long-Evans and Wistar rats.

    Science.gov (United States)

    Hughes, Robert N; Hancock, Nicola J

    2016-01-01

    To assess the possibility that acute caffeine's behavioral action might depend on rats' strain, effects of 50mg/kg of the drug were observed on activity, anxiety-related behavior and habituation learning in male and female rats from three different strains, namely PVG/c, Long-Evans and Wistar. All subjects were tested in an open field, an elevated plus maze and a light-dark box. For the three strains combined, increased occupancy of the center of the open field and entries of the open plus-maze arms with caffeine suggested caffeine-induced anxiolysis, whereas increased grooming in the open field, decreased rearing in the plus maze and increased risk assessment in the light-dark box were consistent with anxiogenesis. Caffeine also reduced open-field rearing only for PVG/c rats, and entries into and occupation of the light side of the light-dark box only for Long-Evans rats, and increased total defecation in the three types of apparatus for all three strains combined. Overall, caffeine appeared to be mainly anxiogenic. The drug also increased open-field ambulation for PVG/c rats and walking for all rats, but decreased open-field ambulation and entries into the plus maze closed arms for Wistar rats alone. In general, Wistar rats appeared to be the least and Long-Evans the most anxious of the three strains investigated. Caffeine also decreased within-session habituation of open-field ambulation for PVG/c rats alone, thereby suggesting strain-dependent interference with non-associative learning and short-term memory. Several overall sex differences were also observed that supported female rats being more active and less anxious than males.

  15. Clinical Features of Systemic Lupus Erythematosus Patients Complicated With Evans Syndrome: A Case-Control, Single Center Study.

    Science.gov (United States)

    Zhang, Lili; Wu, Xiuhua; Wang, Laifang; Li, Jing; Chen, Hua; Zhao, Yan; Zheng, Wenjie

    2016-04-01

    The aim of the study was to investigate the clinical features of systemic lupus erythematous (SLE) complicated with Evans syndrome (ES). We conducted a retrospective case-control study to compare the clinical and laboratory features of age- and gender-matched lupus patients with and without ES in 1:3 ratios. In 5724 hospitalized SLE patients, we identified 27 (0.47%, 22 women and 5 men, average age 34.2 years) SLE patients complicated with ES. Fifteen patients (55.6%) presented with hematologic abnormalities initially, including 6 (22.2%) cases of isolated ITP, 4 (14.8%) cases of isolated AIHA, and 5 (18.5%) cases of classical ES. The median intervals between hematological presentations the diagnosis of SLE was 36 months (range 0-252). ES developed after the SLE diagnosis in 4 patients (14.8%), and concomitantly with SLE diagnosis in 8 patients (29.6%). Systemic involvements are frequently observed in SLE patients with ES, including fever (55.6%), serositis (51.9%), hair loss (40.7%), lupus nephritis (37%), Raynaud phenomenon (33.3%), neuropsychiatric (33.3%) and pulmonary involvement (25.9%), and photosensitivity (25.9%). The incidence of photosensitivity, hypocomplementemia, elevated serum IgG level, and lupus nephritis in patients with ES or without ES was 25.9% vs 6.2% (P = 0.007), 88.9% vs 67.1% (P = 0.029), 48.1% vs 24.4% (P = 0.021), and 37% vs 64.2% (P = 0.013), respectively. Twenty-five (92.6%) patients achieved improvement following treatment of glucocorticoids and immunosuppressants as well as splenectomy, whereas 6 patients experienced the relapse and 1 patient died from renal failure during the follow-up. ES is a relatively rare complication of SLE. Photosensitivity, hypocomplementemia, and elevated serum IgG level were frequently observed in ES patients, but lupus nephritis was less observed. More than half of patients presented with hematological manifestation at onset, and progress to typical lupus over months to years. Therefore

  16. Removal of Evans Blue and Yellow thiazole dyes from aqueous solution by Mg-Al-CO3 Layered Double Hydroxides as anion-exchanger

    OpenAIRE

    Mohamed Bouraada; Louis Charles de Ménorval; Hassiba Bessaha

    2014-01-01

    Mg-Al-CO3 Layered double hydroxide (LDH) was prepared by co-precipitation method at constant pH, and subsequently used to remove Evans Blue (EB) and Yellow thiazole (YT) dyes from aqueous solutions. The obtained material was characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), thermal analysis and BET. The kinetic and equilibrium aspects of sorption of the anionic dyes from aqueous solution by Mg-Al-CO3 were investigated in batch mode. The sorp...

  17. Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease

    OpenAIRE

    Shimada, Hideaki; Takahashi, Makiko; SHIMADA, Akinori; Okawara, Tadashi; Yasutake, Akira; Imamura, Yorishige; Kiyozumi, Morio; シマダ, ヒデアキ; タカハシ, マキコ; シマダ, アキノリ; オオカワラ, タダシ; ヤスタケ, アキラ; イマムラ, ヨリシゲ; キヨズミ, モリオ; 島田, 秀昭

    2005-01-01

    The Long-Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson’s disease in humans. We compared the effects of three metal chelating agents, N-benzyl-D-glucamine dithiocarbamate (BGD), D-penicillamine (D-PEN), and triethylenetetramine (TETA) on the biliary and urinary excretions of Cu using LEC rats. The animals were treated ip with each chelating agent (1 mmol/kg body weight) and then the...

  18. Successful treatment of life-threatening Evans syndrome due to antiphospholipid antibody syndrome by rituximab-based regimen: a case with long-term follow-up.

    Science.gov (United States)

    Rückert, A; Glimm, H; Lübbert, M; Grüllich, C

    2008-08-01

    An association of antiphospholipid antibody syndrome with antibodies directed against either phospholipids or plasma proteins strongly suggest that B-cell dysfunction may be involved in its pathogenesis. Antiphospholipid antibody syndrome with autoimmune cytopenias shows a poor response rate to conventional treatment with anticoagulants, glucocorticosteroids, immunosuppressive agents, intravenous immunoglobulin or plasmapheresis. We report a case of life-threatening antiphospholipid antibody syndrome with Evans syndrome receiving successful multimodal treatment including anti-CD20 monoclonal antibody rituximab with long-term follow-up.

  19. Rootsi saamid võitlevad õiguse eest maale / Sarah Edmonds

    Index Scriptorium Estoniae

    Edmonds, Sarah

    2007-01-01

    Rootsi saamide parlamendil on 1. jaanuarist õigus määrata kohalikud piirid ja jagada abiraha loomasööda ostmiseks ja kompensatsioonide maksmiseks. Nüüd soovivad saamid maaga seotud küsimuste lahendamist. Lisa: Rootsi tõrjub põlisasukate konventsiooni

  20. Kui seks tekitab šoki / Patricia Edmonds

    Index Scriptorium Estoniae

    Edmonds, Patricia

    2016-01-01

    Saare-salehundlase vastsed söövad saarepuu niint ja põhjustavad puu surma. Kahjurite püüdmiseks on putukateadlane Michael Domingue töörühmaga loonud patareidega töötava valeemase, mis annab tema otsa roninud isasele surmava elektrilöögi

  1. Rootsi saamid võitlevad õiguse eest maale / Sarah Edmonds

    Index Scriptorium Estoniae

    Edmonds, Sarah

    2007-01-01

    Rootsi saamide parlamendil on 1. jaanuarist õigus määrata kohalikud piirid ja jagada abiraha loomasööda ostmiseks ja kompensatsioonide maksmiseks. Nüüd soovivad saamid maaga seotud küsimuste lahendamist. Lisa: Rootsi tõrjub põlisasukate konventsiooni

  2. Removal of Evans Blue and Yellow thiazole dyes from aqueous solution by Mg-Al-CO3 Layered Double Hydroxides as anion-exchanger

    Directory of Open Access Journals (Sweden)

    Mohamed Bouraada

    2014-06-01

    Full Text Available Mg-Al-CO3 Layered double hydroxide (LDH was prepared by co-precipitation method at constant pH, and subsequently used to remove Evans Blue (EB and Yellow thiazole (YT dyes from aqueous solutions. The obtained material was characterized by powder X-ray diffraction (PXRD, Fourier transform infrared spectroscopy (FTIR, thermal analysis and BET. The kinetic and equilibrium aspects of sorption of the anionic dyes from aqueous solution by Mg-Al-CO3 were investigated in batch mode. The sorption kinetic data were found to be consistent with the pseudo-second-order model. Data for YT and EB sorption by Mg-Al-CO3 were fitted better by the Langmuir equation than by the Freundlich equation based on the determination coefficient values R2 . The maximum adsorption capacities of 222.2 mgg-1 for Yellow thiazole and 107.5 mgg-1 for Evans blue. The thermodynamic parameters including Gibbs free energy (G°, standard enthalpy change (H°, and standard entropy change (S° for the process were calculated. The negative G° value indicates the spontaneity of the removal process.

  3. Synthesis and radioiodination of di-iodo-Evan's blue via isotopic exchange reaction in the molten state and evaluation of the kinetics

    Energy Technology Data Exchange (ETDEWEB)

    El-Azony, K.M. [Research Center Juelich (Germany). Inst. of Nuclear Chemistry]|[Hot Lab. Center, Cairo (Egypt). Radioactive Isotopes and Generators Dept.; Bier, D.; Coenen, H.H. [Research Center Juelich (Germany). Inst. of Nuclear Chemistry

    2004-07-01

    Many aryl halides were synthesized from aryl amines such as iodo-trypan, iodo-methylene blue and iodo-toluidine. Methylene blue and toludine blue are phenothiazinium dyes and were used to localize parathyroid glands visually during surgery. Radioiodination of these compounds by using iodine-123 analogues for scintgraphic localization of parathyroids was reported. Radiolabelled dyes administered may also localize in tumor tissues. Evan's blue dye was used to study altered sarcolemmal permeability in dystrophic muscle fibers, and in animals to study muscular dystrophy. In this work Diiodo-Evan's blue was synthesized via Sandmeyer reaction and characterized by mass spectrum analysis. A procedure for labelling DIEB with Na{sup 131}I via isotopic exchange in molten medium was developed. The labelling conditions studied for the isotopic exchange of {sup 131}I-for-I in DIEB included the effect of temperature and solvents (melt of acetamide, benzoic and pivalic acid). Kinetic studies were performed to obtain [{sup 131}I] DIEB with more reliable reaction conditions. Quality control for the final product ([{sup 131}I] DIEB) was performed by HPLC. (orig.)

  4. Development of mixed-type autoimmune hemolytic anemia and Evans' syndrome following chicken pox infection in a case of low-titer cold agglutinin disease.

    Science.gov (United States)

    Tanaka, Yumi; Masuya, Masahiro; Katayama, Naoyuki; Miyata, Eri; Sugimoto, Yuka; Shibasaki, Tetsunori; Yamamura, Kentaro; Ohishi, Kohshi; Minami, Nobuyuki; Shiku, Hiroshi; Nobori, Tsutomu

    2006-10-01

    We describe a patient with low-titer cold agglutinin disease (CAD) who developed mixed-type autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenia following chicken pox infection. At least 1 year before admission to hospital, the patient had mild hemolytic anemia associated with low-titer cold agglutinins. A severe hemolytic crisis and thrombocytopenia (Evans' syndrome) occurred several days after infection with chicken pox, and the patient was referred to our hospital. Serological findings revealed the presence of both cold agglutinins and warm-reactive autoantibodies against erythrocytes, and the diagnosis was mixed-type AIHA. Following steroid therapy, the hemoglobin (Hb) level and platelet count improved. The patient was closely followed over a 10-year period with recurrent documented hemolysis after viral or bacterial infections. Warm-reactive autoantibodies have not been detected in the last 2 years, and only the immunoglobulin M anti-I cold agglutinins with a low titer and wide thermal amplitude have remained unchanged. Therefore, the patient has received at least 10 mg prednisolone daily to maintain a Hb level of 10 g/dL. To the best of our knowledge, no adult case of low-titer CAD that has evolved into mixed-type AIHA and Evans' syndrome after chicken pox infection has been previously reported in the literature.

  5. Evans-Showell-Type Polyoxometalates Constructing High-Dimensional Inorganic-Organic Hybrid Compounds with Copper-Organic Coordination Complexes: Synthesis and Oxidation Catalysis.

    Science.gov (United States)

    An, Haiyan; Hou, Yujiao; Wang, Lin; Zhang, Yumeng; Yang, Wei; Chang, ShenZhen

    2017-10-02

    Four new hybrid architectures containing a [Co2Mo10H4O38](6-) polyoxoanion, (en)[Cu3(ptz)4(H2O)4][Co2Mo10H4O38]·24H2O (1), (Hbim)2[{Cu(bim)2(H2O)2}2{Co2Mo10H4O38}]·5H2O (2), H2[Cu(dpdo)3(H2O)4][{Cu2(dpdo)3(H2O)4(CH3CN)}2{Co2Mo10H4O38}2]·9H2O (3), and (H2bpp)4[{Cu(H2O)2}{NaCo2Mo10H4O38}2]·10H2O (4), where ptz = 5-(4-pyridyl)-1H-tetrazole, en = ethylenediamine, bim = benzimidazole, dpdo = 4,4'-bipyridine-N,N'-dioxide, and bpp = 1,3-bis(4-pyridyl)propane, have been prepared and characterized through elemental analysis, thermogravimetric analysis, IR spectroscopy, and powder and single-crystal X-ray diffraction. Compound 1 shows a 3D host-guest framework composed of 3D Cu-ptz as the host and Evans-Showell-type polyoxoanion [Co2Mo10H4O38](6-) as the guest. Compound 2 is constructed from [Co2Mo10H4O38](6-) polyoxoanions and Cu-bim coordination complexes to form a 2D covalent layer. Compound 3 also exhibits a 2D hybrid network based on [Co2Mo10H4O38](6-) polyoxoanions linked by Cu-dpdo coordination groups. Compound 4 is a 1D double-chain structure composed of [Co2Mo10H4O38](6-) polyoxoanions joined together by Na(+) and Cu(2+) cations. As far as we know, compound 1 is the first host-guest compound with an Evans-Showell-type polyoxometalate as the guest, and compounds 2 and 3 are the first 2D inorganic-organic hybrid architectures constructed from Evans-Showell-type polyoxometalates. Compounds 1-4 are redox catalysts that heterogeneously prompt sulfide and alcohol oxidation with excellent efficiency.

  6. Maternal behavior priming in virgin and caesarean-delivered Long-Evans rats: effects of brief contact or continuous exteroceptive pup stimulation.

    Science.gov (United States)

    Stern, J M

    1983-12-01

    The effects of 8 days of prior exposure to pups (Priming) in the form of continuous exteroceptive (smell, sight and sound), or 15 min/day physical access (taste and touch possible) stimulation on the subsequent latency to become maternal during cohabitation with pups (concaveation) was studied in Long-Evans female rats. Brief daily access was effective in hastening the onset of maternal behavior only in those virgins which engaged in pup licking during Priming and in maintaining short-latency maternal responsiveness only in those day 21 pregnancy-terminated, thelectomized rats which initiated maternal behavior during Priming. Exteroceptive stimulation was ineffective in both virgins and caesarean-sectioned rats. These findings stress the importance of physical interactions with pups (unrelated to nipple stimulation) for the development of nurturance.

  7. Multiple (/sup 3/H)imipramine binding sites in brains of male and female Fawn-Hooded and Long-Evans rats

    Energy Technology Data Exchange (ETDEWEB)

    Ieni, J.R.; Zukin, S.R.; Praag, H.M. van; Tobach, E.; Barr, G.A.

    1985-06-07

    Comparisons of high- and low-affinity (/sup 3/H)imipramine binding to whole brain homogenates from adult male and female rats of the Fawn-Hooded and Long-Evans strains were performed. Most strikingly, no significant differences were observed between the two strains in any of the binding parameters, indicating that brain (/sup 3/H)imipramine binding sites, which may be related to the serotonergic uptake process, appear normal in a strain of rats with serotonin platelet storage pool disease. However, a significant sex difference in high- but not low-affinity whole brain (/sup 3/H)imipramine Bsub(max) values was observed, with females of both strains having higher densities than males.

  8. Four weeks' inhalation exposure of Long Evans rats to 4-tert-butyltoluene: Effect on evoked potentials, behaviour and brain neurochemistry

    DEFF Research Database (Denmark)

    Lam, Henrik Rye; Ladefoged, Ole; Østergaard, Grete

    2000-01-01

    Long-lasting central nervous system (CNS) neurotoxicity of 4-tert-butyltoluene (TBT) has been investigated using electrophysiology, behaviour, and neurochemistry in Long Evans rats exposed by inhalation to 0, 20, or 40 p.p.m. TBT 6 hr/day, 7 days/week for 4 weeks. Flash evoked potentials...... and somatosensory evoked potentials were not affected by TBT In Auditory Brain Stem Response there was no shift in hearing threshold, but the amplitude of the first wave was increased in both exposed groups at high stimulus levels. Three to four months after the end of exposure, behavioural studies in Morris water...... maze and eight-arm maze failed to demonstrate any TBT induced effects. Exposure was followed by a 5 months exposure-free period prior to gross regional and subcellular (synaptosomal) neurochemical investigations of the brain. TBT reduced the NA concentration in whole brain minus cerebellum...

  9. Evans Blue Staining Reveals Vascular Leakage Associated with Focal Areas of Host-Parasite Interaction in Brains of Pigs Infected with Taenia solium

    Science.gov (United States)

    Paredes, Adriana; Cangalaya, Carla; Rivera, Andrea; Gonzalez, Armando E.; Mahanty, Siddhartha; Garcia, Hector H.; Nash, Theodore E.

    2014-01-01

    Cysticidal drug treatment of viable Taenia solium brain parenchymal cysts leads to an acute pericystic host inflammatory response and blood brain barrier breakdown (BBB), commonly resulting in seizures. Naturally infected pigs, untreated or treated one time with praziquantel were sacrificed at 48 hr and 120 hr following the injection of Evans blue (EB) to assess the effect of treatment on larval parasites and surrounding tissue. Examination of harvested non encapsulated muscle cysts unexpectedly revealed one or more small, focal round region(s) of Evans blue dye infiltration (REBI) on the surface of otherwise non dye-stained muscle cysts. Histopathological analysis of REBI revealed focal areas of eosinophil-rich inflammatory infiltrates that migrated from the capsule into the tegument and internal structures of the parasite. In addition some encapsulated brain cysts, in which the presence of REBI could not be directly assessed, showed histopathology identical to that of the REBI. Muscle cysts with REBI were more frequent in pigs that had received praziquantel (6.6% of 3736 cysts; n = 6 pigs) than in those that were untreated (0.2% of 3172 cysts; n = 2 pigs). Similar results were found in the brain, where 20.7% of 29 cysts showed histopathology identical to muscle REBI cysts in praziquantel-treated pigs compared to the 4.3% of 47 cysts in untreated pigs. Closer examination of REBI infiltrates showed that EB was taken up only by eosinophils, a major component of the cellular infiltrates, which likely explains persistence of EB in the REBI. REBI likely represent early damaging host responses to T. solium cysts and highlight the focal nature of this initial host response and the importance of eosinophils at sites of host-parasite interaction. These findings suggest new avenues for immunomodulation to reduce inflammatory side effects of anthelmintic therapy. PMID:24915533

  10. Evans blue staining reveals vascular leakage associated with focal areas of host-parasite interaction in brains of pigs infected with Taenia solium.

    Science.gov (United States)

    Marzal, Miguel; Guerra-Giraldez, Cristina; Paredes, Adriana; Cangalaya, Carla; Rivera, Andrea; Gonzalez, Armando E; Mahanty, Siddhartha; Garcia, Hector H; Nash, Theodore E

    2014-01-01

    Cysticidal drug treatment of viable Taenia solium brain parenchymal cysts leads to an acute pericystic host inflammatory response and blood brain barrier breakdown (BBB), commonly resulting in seizures. Naturally infected pigs, untreated or treated one time with praziquantel were sacrificed at 48 hr and 120 hr following the injection of Evans blue (EB) to assess the effect of treatment on larval parasites and surrounding tissue. Examination of harvested non encapsulated muscle cysts unexpectedly revealed one or more small, focal round region(s) of Evans blue dye infiltration (REBI) on the surface of otherwise non dye-stained muscle cysts. Histopathological analysis of REBI revealed focal areas of eosinophil-rich inflammatory infiltrates that migrated from the capsule into the tegument and internal structures of the parasite. In addition some encapsulated brain cysts, in which the presence of REBI could not be directly assessed, showed histopathology identical to that of the REBI. Muscle cysts with REBI were more frequent in pigs that had received praziquantel (6.6% of 3736 cysts; n = 6 pigs) than in those that were untreated (0.2% of 3172 cysts; n = 2 pigs). Similar results were found in the brain, where 20.7% of 29 cysts showed histopathology identical to muscle REBI cysts in praziquantel-treated pigs compared to the 4.3% of 47 cysts in untreated pigs. Closer examination of REBI infiltrates showed that EB was taken up only by eosinophils, a major component of the cellular infiltrates, which likely explains persistence of EB in the REBI. REBI likely represent early damaging host responses to T. solium cysts and highlight the focal nature of this initial host response and the importance of eosinophils at sites of host-parasite interaction. These findings suggest new avenues for immunomodulation to reduce inflammatory side effects of anthelmintic therapy.

  11. The effect of subcutaneous tetrathiomolybdate administration on copper and iron metabolism, including their regional redistribution in the brain, in the Long-Evans Cinnamon rat, a bona fide animal model for Wilson's disease.

    Science.gov (United States)

    Sugawara, N; Ikeda, T; Lai, Y R; Sugawara, C

    1999-05-01

    The present work was performed to examine the effect of tetrathiomolybdate on Cu and Fe metabolism, especially redistribution of Cu and Fe in the brains of Long-Evans Cinnamon rats, with inherently abnormal Cu deposition in the liver. The drug was injected subcutaneously at 5 mg/kg of body weight twice a week for 65 days (total dose of 20 mg) into 40-day-old Long-Evans Cinnamon rats. In Long-Evans Cinnamon rats treated with tetrathiomolybdate, the hepatic Cu concentration was 60 microg/g wet weight, compared to 170 microg/g in untreated rats. In seven brain regions (cerebellum, medulla oblongata, hypothalamus, striatum, midbrain, hippocampus and cortex) of the Long-Evans Cinnamon rats treated with tetrathiomolybdate. the Cu concentration (1.5 to 2.3 microg/g) was slightly lower (1.6 to 2.7 microg/g) than in untreated rats. A significant difference between the two groups was found only in the midbrain. Brain Fe concentrations in regions other than the striatum were not changed significantly by the tetrathiomolybdate injections. The hepatic Fe concentration was about 120 microg/g in Long-Evans Cinnamon rats without tetrathiomolybdate. Tetrathiomolybdate injection further increased the concentration to about 250 microg/g. Our results indicated that subcutaneous tetrathiomolybdate injection did not have an effect that stimulated redistribution of Cu and Fe in the seven brain regions examined, although hepatic Cu was markedly decreased and the removed Cu was deposited in kidneys, spleen and testes. The increased hepatic Fe level should be taken into account when considering side effects of the compound.

  12. El método de Evans & Mcgreevy como herramienta para el estudio aloídico in vivo y post mortem. Una aplicación en caballos (The Evans & Mcreevy method as a tool to the profile study in vivo and post mortem. An application to horses

    Directory of Open Access Journals (Sweden)

    Parés i Casanova, Pere-Miquel

    2007-09-01

    Full Text Available ResumenNo existe un método objetivo para la cuantificación del perfil cefálico equino. Este estudio propone un método basado en una publicación previa de Evans y McGreevy (2006, que es válido tanto para caballos muertos como vivos, y que permite la obtención de diferentes áreas de perfil cefálico, que pueden tener un importante valor en etnología animal. Como ejemplo de esta metodología, introducimos los valores obtenidos in vivo de algunos machos y hembras de la raza equina Agrupació Hipermètrica Pirinenca. AbstractThere is a lack of an objective method for quantifying equine skull profile.This study proposes a method based on a previous publication by Evans and McGreevy (2006. This method is valid for using on both living and deceased horses and it allows obtaining different cephalic profile areas, which have an important value in animal ethnology. As an example of this methodology, we introduce the values obtained in vivo from some males and females belonging to the Agrupació Hipermètrica Pirinenca equine breed.

  13. Competition between copper and silver in Fischer rats with a normal copper metabolism and in Long-Evans Cinnamon rats with an abnormal copper metabolism

    Energy Technology Data Exchange (ETDEWEB)

    Sugawara, N.; Sugawara, C. [Sapporo Medical Univ. (Japan). Dept. of Public Health

    2000-07-01

    Long-Evans Cinnamon (LEC) rats inherently lacking in serum ceruloplasmin (CP) activity and biliary Cu excretion were established from a closed colony of Long-Evans rats. These deficiencies, linked to a dysfunction of P-type ATPase, stimulate deposition of Cu and then of Cu metallothionein (MT) in the liver. Male LEC and Fischer rats were injected subcutaneously with Ag (AgNO{sub 3}), which is an antagonist to Cu. They were operated on 24 h after the injection while under anesthesia. Total uptake of Ag into the liver was not stimulated, but its uptake into the MT fraction increased significantly in the LEC rats. Ag injection notably decreased the activity of serum CP in the Fischer rats, but not in the LEC rats. The decrease was accompanied by a reduction of serum Cu. In Fischer rat serum treated with Ag, Ag was detected mainly in the albumin region and partly in the CP fraction. In LEC rat serum, however, the Ag concentration was about 1/20 of that in the Fischer rats, and Ag was not detected in the CP fraction. Ag injection decreased the biliary excretion of Cu in the Fischer rats (0.183-0.052 {mu}g Cu/20 min sampling), but not in the LEC rats (0.014-0.014 {mu}g Cu/20 min sampling). On the other hand, biliary excretion of Ag was much greater in the Fischer rats (1.25 {mu}g Ag/20 min) than in the LEC rats (0.04 {mu}g Ag/20 min). Our results suggest that uptake of Ag into the liver is not dependent on the hepatic Cu content and status, but that biliary excretion of Ag from the liver is affected by these. Hepatic MT is not a transporter of hepatobiliary excretion of Cu and Ag. It seems likely that, unlike Cu excretion, Ag is excreted by not only the CP route but also by another route into the serum. Ag may compete with Cu in the uptake into CP (conversion of apo-CP to holo-CP). (orig.)

  14. Effects of granulocyte-colony stimulating factor (G-CSF on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats

    Directory of Open Access Journals (Sweden)

    Kim Jung-Hyun

    2011-10-01

    Full Text Available Abstract Background Diabetic cardiomyopathy (CMP is a common and disabling disease in diabetic patients, however no effective treatments have been developed. Although granulocyte-colony stimulating factor (G-CSF improves heart function in myocardial infarction, its effect on non-ischemic CMP such as diabetic CMP is unknown. In the present study, we investigated the effects of G-CSF on diabetic CMP in a rat model of type II diabetes. Methods Twenty 7-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF: a rat model of diabetes rats and 10 male Long-Evans Tokushima Otsuka (LETO: normal controls rats were used. All of the LETO and 8 OLETF rats were fed on tap water while the rest were fed on sucrose-containing water. After 10 weeks, saline or recombinant human G-CSF (100 μg/kg/day was injected intraperitoneally for 5 days. Blood levels of glucose, total cholesterol and triglyceride, and Doppler echocardiograms for diastolic dysfunction were obtained just before and 4 weeks after the saline or G-CSF treatment. Light microscopy, electron microscopy (EM and immunohistochemistry for transforming growth factor-β were employed to examine myocardial histology 4 weeks after the saline or G-CSF treatment. Results Diastolic dysfunction developed at 17 weeks (before the saline or G-CSF treatment in the OLETF rats whether or not they were fed sucrose water, but were more severe in those fed sucrose water. Four weeks after saline or G-CSF treatment, diastolic function had recovered in the G-CSF-treated group regardless of sucrose water feeding, and perivascular and/or interstitial fibrosis in the G-CSF-treated group had decreased significantly. TGF-β immunoreactivity in the interstitial and perivascular tissue was also reduced in the G-CSF-treated group, and EM studies revealed less severe disruption of myofilaments and mitochondrial cristae, and decreased collagen deposition. Conclusions G-CSF can ameliorate cardiac diastolic dysfunction and morphological

  15. Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes

    Science.gov (United States)

    Oh, Da Hee; Kim, Jung Yeon; Lee, Bong Gn; You, Jeong Soon; Chang, Kyung Ja; Chung, Hyunju; Yoo, Myung Chul; Yang, Hyung-In; Kang, Ja-Heon; Hwang, Yoo Chul; Ahn, Kue Jeong; Chung, Ho-Yeon

    2012-01-01

    This study aimed to determine whether taurine supplementation improves metabolic disturbances and diabetic complications in an animal model for type 2 diabetes. We investigated whether taurine has therapeutic effects on glucose metabolism, lipid metabolism, and diabetic complications in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term duration of diabetes. Fourteen 50-week-old OLETF rats with chronic diabetes were fed a diet supplemented with taurine (2%) or a non-supplemented control diet for 12 weeks. Taurine reduced blood glucose levels over 12 weeks, and improved OGTT outcomes at 6 weeks after taurine supplementation, in OLETF rats. Taurine significantly reduced insulin resistance but did not improve β-cell function or islet mass. After 12 weeks, taurine significantly decreased serum levels of lipids such as triglyceride, cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol. Taurine significantly reduced serum leptin, but not adiponectin levels. However, taurine had no therapeutic effect on damaged tissues. Taurine ameliorated hyperglycemia and dyslipidemia, at least in part, by improving insulin sensitivity and leptin modulation in OLETF rats with long-term diabetes. Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients. PMID:23114424

  16. Role of p38 Mapk in development of acute hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model of human Wilson's disease.

    Science.gov (United States)

    Kadowaki, Shingo; Meguro, Saori; Imaizumi, Yoshitaka; Sakai, Hiroshi; Endoh, Daiji; Hayashi, Masanobu

    2013-12-30

    The Long-Evans Cinnamon (LEC) rat, an animal model of human Wilson's disease, spontaneously develops fulminant hepatitis associated with severe jaundice at about 4 months of age. In this study, we examined the changes in gene expression during progression of acute hepatic injury. When levels of gene expression in the liver of LEC rats at 13 weeks of age were compared to those in rats at 4 weeks of age using oligonucleotide arrays, 1,620 genes out of 7,700 genes analyzed showed more than 2-fold differences. Expression levels of 11 of 29 genes related to stress-activating protein kinase (SAPK) changed by more than 2-fold in the liver of LEC rats, but none of the SAPK-related genes showed changes in expression levels in the liver of control rats. Activity of p38 mapk in the liver of LEC rats at 13 weeks of age was about 8.1-fold higher than that in rats at 4 weeks of age. When LEC rats were administered SB203580, a p38 mapk-specific inhibitor, by s.c. injection twice a week from 10 to 13 weeks of age, activities of p38 mapk in the liver, activities of AST and ALT and concentrations of bilirubin in sera of rats administered SB203580 significantly decreased compared to those in rats not administered. These results showed that the increase in activities of p38 mapk was related to the occurrence of acute hepatic injury in LEC rats.

  17. New Perspectives for Old Clusters: Anderson-Evans Anions as Building Blocks of Large Polyoxometalate Frameworks in a Series of Heterometallic 3 d-4 f Species.

    Science.gov (United States)

    Artetxe, Beñat; Reinoso, Santiago; San Felices, Leire; Lezama, Luis; Gutiérrez-Zorrilla, Juan M; Vicent, Cristian; Haso, Fadi; Liu, Tianbo

    2016-03-18

    A series of nine [Sb7W36O133Ln3M2(OAc)(H2O)8](17-) heterometallic anions (Ln3M2; Ln=La-Gd, M=Co; Ln=Ce, M=Ni and Zn) have been obtained by reacting 3 d metal disubstituted Krebs-type tungstoantimonates(III) with early lanthanides. Their unique tetrameric structure contains a novel {MW9O33} capping unit formed by a planar {MW6O24} fragment to which three {WO2} groups are condensed to form a tungstate skeleton identical to that of a hypothetical trilacunary derivative of the ɛ-Keggin cluster. It is shown, for the first time, that classical Anderson-Evans {MW6O24} anions can act as building blocks to construct purely inorganic large frameworks. Unprecedented reactivity in the outer ring of these disk-shaped species is also revealed. The Ln3M2 anions possess chirality owing to a {Sb4O4} cluster being encapsulated in left- or right-handed orientations. Their ability to self-associate in blackberry-type vesicles in solution has been assessed for the Ce3Co2 derivative.

  18. Disturbance of response to acute thermal pain in naturally occurring cholecystokinin-a receptor gene knockout Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

    Science.gov (United States)

    Miyasaka, Kyoko; Nomoto, Shigeki; Ohta, Minoru; Kanai, Setsuko; Kaneko, Takao; Tahara, Shoichi; Funakoshi, Akihiro

    2006-08-01

    Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack cholecystokinin-A receptor (CCK-AR) because of a genetic abnormality. We observed that body temperature homeostasis in response to changes in ambient temperature was deteriorated in OLETF rats, while the functions of the signal outputs from the hypothalamus to effectors were not impaired. Deteriorated homeostasis was also seen in CCK-AR deficient (-/-) mice. In the present study, we examined whether the sensory pathway involved in transmitting signals about temperature from the skin to the brain was impaired in OLETF rats. To elucidate the involvement of CCK-AR function, we conducted the same experiment in CCK-AR(-/-) mice. Responses to thermal pain were assessed using the Hargreaves' plantar test apparatus. Shortening of withdrawal latency was observed in OLETF rats compared to control rats, indicating thermal hyperalgesia. Behavioral responses following paw withdrawal were disturbed in OLETF rats. The 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid contents in the hippocampus and frontal cortex of OLETF rats were significantly higher than in those of the controls. CCK-AR(-/-) mice did not show any differences from wild-type mice. In conclusion, OLETF rats showed thermal hyperalgesia and disturbed responses to thermal pain, and an alteration of 5-HT function might have a role in this disturbance.

  19. Investigation of DNA synthesis in experimentally induced Long-Evans rat myeloschisis by the BrdU/antiBrdU technique.

    Science.gov (United States)

    Chono, Y; Abe, H; Iwasaki, Y; Nagashima, K

    1994-04-01

    The volume and DNA synthesis of the neuroepithelium in induced myeloschisis in Long-Evans rats as shown by hematoxylin-eosin and BrdU/antiBrdU immunohistochemical staining patterns were examined at different stages of embryonal development. On day 14 of gestation, control animals contained BrdU-incorporating cells mainly at the alar plate of the closed neural tube. On the same day, the everted neural plate of rats with myeloschisis showed active, diffuse uptake of BrdU in the cells of the matrix layer, although an increase in the volume of the everted neural plate was not yet identifiable. On day 21 of gestation, rats with myeloschisis showed a marked increase in the volume of the neuroepithelium compared with controls. Our investigations suggest that, in myeloschisis, more neuroepithelial cells than normal retain their capability for DNA synthesis on day 14 of gestation, and the overgrowth of the neuroepithelium found on day 21 is possibly a secondary effect of failure of neural tube closure.

  20. Protection from spontaneous hepatocellular damage by N-benzyl-d-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease.

    Science.gov (United States)

    Shimada, Hideaki; Takahashi, Makiko; Shimada, Akinori; Okawara, Tadashi; Yasutake, Akira; Imamura, Yorishige; Kiyozumi, Morio

    2005-01-01

    The Long-Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson's disease in humans. We compared the effects of three metal chelating agents, N-benzyl-d-glucamine dithiocarbamate (BGD), d-penicillamine (D-PEN), and triethylenetetramine (TETA), on the biliary and urinary excretions of Cu using LEC rats. The animals were treated ip with each chelating agent (1 mmol/kg body weight) and then the bile and urine samples were collected for 3 h. Because single treatment with BGD markedly stimulated biliary excretion of Cu, the protective effect of repeated BGD injection on spontaneous hepatocellular damage was further examined. Separate groups received two weekly injections of BGD starting at 11 weeks of age and were compared to saline-injected controls. Serum alanine aminotransferase (ALT) activity and bilirubin level were significantly increased in control LEC rats by 19 weeks of age and histopathological analysis demonstrated extensive hepatic damage in these rats. However, repeated BGD injections prevented the increases in serum ALT and bilirubin and blocked the histopathological changes in the liver. Furthermore, although Cu rapidly accumulated in the liver, kidney, spleen, and serum of control LEC rats during the test period, repeated BGD injection largely prevented these increases. These results indicate that BGD treatment is effective in blocking excessive Cu accumulation in LEC rats that, in turn, provides protection from spontaneous liver damage.

  1. Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral administration of sucrose or maple syrup.

    Science.gov (United States)

    Nagai, Noriaki; Ito, Yoshimasa; Taga, Atsushi

    2013-01-01

    Maple syrup is used as a premium natural sweeter, and is known for being good for human health. In the present study, we investigate whether maple syrup is suitable as a sweetener in the management of type 2 diabetes using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type 2 diabetes mellitus. OLETF rats develop type 2 diabetes mellitus by 30 weeks of age, and 60-week-old OLETF rats show hyperglycemia and hypoinsulinemia via pancreatic β-cell dysfunction. The administration of sucrose or maple syrup following an OGT test increased plasma glucose (PG) levels in OLETF rats, but the enhancement in PG following the oral administration of maple syrup was lower than in the case of sucrose administration in both 30- and 60-week-old OLETF rats. Although, the insulin levels in 30-week-old OLETF rats also increased following the oral administration of sucrose or maple syrup, no increase in insulin levels was seen in 60-week-old OLETF rats following the oral administration of either sucrose or maple syrup. No significant differences were observed in insulin levels between sucrose- and maple syrup-administered OLETF rats at either 30 or 60 weeks of age. The present study strongly suggests that the maple syrup may have a lower glycemic index than sucrose, which may help in the prevention of type 2 diabetes.

  2. Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF Rats with a Combination of Chinese Herbs (Tangshen Formula

    Directory of Open Access Journals (Sweden)

    Haojun Zhang

    2011-01-01

    Full Text Available Diabetic nephropathy is one of the most significant microvascular complications in patients with type 2 diabetics. The concise mechanism of diabetic nephropathy is unknown and there is no successful treatment. The objective of study was to investigate effects of Chinese herbs (Tangshen Formula on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF rats. OLETF rats and LETO rats were divided into four groups: LETO control, OLETF diabetics, OLETF diabetics treated with Tangshen Formula, and OLETF diabetics treated with Monopril. Body weight, blood glucose, and 24 h urinary proteins were measured once every four weeks. Blood samples and kidney tissues were obtained for analyses of total cholesterol, triglyceride, whole blood viscosity, plasma viscosity, and pathohistological examination at 36 and 56 weeksrespectively. Untreated OLETF rats displayed diabetic nephropathy over the study period. Treatment of OLETF rats with Tangshen Formula attenuated the increases in blood glucose, body weight, 24 h urinary protein content, serum total cholesterol, whole blood viscosity and plasma viscosity at certain time. Treatment with Tangshen Formula also reduced glomerulosclerotic index and interstitial fibrotic index seen in OLETF rats. In conclusion, Tangshen Formula could attenuate the development of diabetic nephropathy in OLETF rat diabetic model.

  3. Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

    Science.gov (United States)

    Saunders, Norman R; Dziegielewska, Katarzyna M; Møllgård, Kjeld; Habgood, Mark D

    2015-01-01

    In recent years there has been a resurgence of interest in brain barriers and various roles their intrinsic mechanisms may play in neurological disorders. Such studies require suitable models and markers to demonstrate integrity and functional changes at the interfaces between blood, brain, and cerebrospinal fluid. Studies of brain barrier mechanisms and measurements of plasma volume using dyes have a long-standing history, dating back to the late nineteenth-century. Their use in blood-brain barrier studies continues in spite of their known serious limitations in in vivo applications. These were well known when first introduced, but seem to have been forgotten since. Understanding these limitations is important because Evans blue is still the most commonly used marker of brain barrier integrity and those using it seem oblivious to problems arising from its in vivo application. The introduction of HRP in the mid twentieth-century was an important advance because its reaction product can be visualized at the electron microscopical level, but it also has limitations. Advantages and disadvantages of these markers will be discussed together with a critical evaluation of alternative approaches. There is no single marker suitable for all purposes. A combination of different sized, visualizable dextrans and radiolabeled molecules currently seems to be the most appropriate approach for qualitative and quantitative assessment of barrier integrity.

  4. Reduced hippocampal dendritic spine density and BDNF expression following acute postnatal exposure to di(2-ethylhexyl phthalate in male Long Evans rats.

    Directory of Open Access Journals (Sweden)

    Catherine A Smith

    Full Text Available Early developmental exposure to di(2-ethylhexyl phthalate (DEHP has been linked to a variety of neurodevelopmental changes, particularly in rodents. The primary goal of this work was to establish whether acute postnatal exposure to a low dose of DEHP would alter hippocampal dendritic morphology and BDNF and caspase-3 mRNA expression in male and female Long Evans rats. Treatment with DEHP in male rats led to a reduction in spine density on basal and apical dendrites of neurons in the CA3 dorsal hippocampal region compared to vehicle-treated male controls. Dorsal hippocampal BDNF mRNA expression was also down-regulated in male rats exposed to DEHP. No differences in hippocampal spine density or BDNF mRNA expression were observed in female rats treated with DEHP compared to controls. DEHP treatment did not affect hippocampal caspase-3 mRNA expression in male or female rats. These results suggest a gender-specific vulnerability to early developmental DEHP exposure in male rats whereby postnatal DEHP exposure may interfere with normal synaptogenesis and connectivity in the hippocampus. Decreased expression of BDNF mRNA may represent a molecular mechanism underlying the reduction in dendritic spine density observed in hippocampal CA3 neurons. These findings provide initial evidence for a link between developmental exposure to DEHP, reduced levels of BDNF and hippocampal atrophy in male rats.

  5. Reduced hippocampal dendritic spine density and BDNF expression following acute postnatal exposure to di(2-ethylhexyl) phthalate in male Long Evans rats.

    Science.gov (United States)

    Smith, Catherine A; Holahan, Matthew R

    2014-01-01

    Early developmental exposure to di(2-ethylhexyl) phthalate (DEHP) has been linked to a variety of neurodevelopmental changes, particularly in rodents. The primary goal of this work was to establish whether acute postnatal exposure to a low dose of DEHP would alter hippocampal dendritic morphology and BDNF and caspase-3 mRNA expression in male and female Long Evans rats. Treatment with DEHP in male rats led to a reduction in spine density on basal and apical dendrites of neurons in the CA3 dorsal hippocampal region compared to vehicle-treated male controls. Dorsal hippocampal BDNF mRNA expression was also down-regulated in male rats exposed to DEHP. No differences in hippocampal spine density or BDNF mRNA expression were observed in female rats treated with DEHP compared to controls. DEHP treatment did not affect hippocampal caspase-3 mRNA expression in male or female rats. These results suggest a gender-specific vulnerability to early developmental DEHP exposure in male rats whereby postnatal DEHP exposure may interfere with normal synaptogenesis and connectivity in the hippocampus. Decreased expression of BDNF mRNA may represent a molecular mechanism underlying the reduction in dendritic spine density observed in hippocampal CA3 neurons. These findings provide initial evidence for a link between developmental exposure to DEHP, reduced levels of BDNF and hippocampal atrophy in male rats.

  6. Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats

    Energy Technology Data Exchange (ETDEWEB)

    Stanko, Jason [National Institute of Environmental Health Sciences (NIEHS); Enoch, Rolondo [North Carolina Central University, Durham; Rayner, Jennifer L [ORNL; Davis, Christine [U.S. Environmental Protection Agency; Wolf, Douglas [U.S. Environmental Protection Agency; Malarkey, David [University of North Carolina, Chapel Hill; Fenton, Suzanne [National Institute of Environmental Health Sciences (NIEHS)

    2010-12-01

    The present study examines the postnatal reproductive development of male rats following prenatal exposure to an atrazine metabolite mixture (AMM) consisting of the herbicide atrazine and its environmental metabolites diaminochlorotriazine, hydroxyatrazine, deethylatrazine, and deisopropylatrazine. Pregnant Long-Evans rats were treated by gavage with 0.09, 0.87, or 8.73 mg AMM/kg body weight (BW), vehicle, or 100 mg ATR/kg BW positive control, on gestation days 15 19. Preputial separation was significantly delayed in 0.87 mg and 8.73 mg AMM-exposed males. AMM-exposed males demonstrated a significant treatment-related increase in incidence and severity of inflammation in the prostate on postnatal day (PND) 120. A dose-dependent increase in epididymal fat masses and prostate foci were grossly visible in AMM-exposed offspring. These results indicate that a short, late prenatal exposure to mixture of chlorotriazine metabolites can cause chronic prostatitis in male LE rats. The mode of action for these effects is presently unclear.

  7. Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用

    OpenAIRE

    座間味, 義人; 藤原, 弘喜; 細田, 美穂; 日野, 隼人; 平井, 和浩; 岡本, 和明; 金, 鑫; 高取, 真吾; 高木, 志真; 川﨑, 博己

    2010-01-01

    Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Ins...

  8. An iron-deficient diet stimulates the onset of the hepatitis due to hepatic copper deposition in the Long-Evans Cinnamon (LEC) rat

    Energy Technology Data Exchange (ETDEWEB)

    Sugawara, Naoki; Sugawara, Chieko [Sapporo Medical Univ. (Japan). Dept. of Public Health

    1999-09-01

    To study effects of dietary Cu and Fe levels on the onset of hepatitis in Long-Evans Cinnamon (LEC) rats, female rats (40 days old) were fed a semipurified diet containing 0.1 or 10 mg Cu/kg and 1.5 or 150 mg Fe/kg in a 2 x 2 factorial arrangement for 35 days. At 75 days after birth, LEC rats (+Cu-Fe) fed a Cu-sufficient but Fe-deficient diet (Cu, 10 mg/kg; Fe, 1.5 mg/kg) showed jaundice, with lethargy, anorexia, and malaise. The biochemical variables relating to liver function were significantly increased compared to three other groups, a Cu- and Fe-deficient (-Cu-Fe) group, a Cu-deficient but Fe-sufficient (-Cu+Fe) group, and a Cu and Fe sufficient (+Cu+Fe) group. Furthermore, the +Cu-Fe rat liver showed massive necrosis with huge nuclei. The other three groups presented no biochemical and histological findings of hepatitis. Hepatic Cu and metallothionein concentrations were 289 {+-} 87 (mean {+-} SD) {mu}g/g liver and 8.7 {+-} 1.8 mg/g liver, respectively, in the +Cu-Fe rats. However, in the +Cu+Fe group the values were 196 {+-} 28 {mu}g Cu/g liver and 10.8 {+-} 1.0 mg/g liver. Hepatic Fe deposition was not influenced significantly by the dietary Cu level. The +Cu-Fe group with jaundice showed the highest free Cu concentration in the liver among the four groups, but the hepatic free Fe concentration was similar to those in the -Cu+Fe and +Cu+Fe groups. Our results indicate that an Fe-deficient diet enhances the deposition of hepatic Cu due to increased absorption of Cu from the gastrointestinal tract. This deposition stimulated the onset of hepatitis. (orig.)

  9. Inactivating the infralimbic but not prelimbic medial prefrontal cortex facilitates the extinction of appetitive Pavlovian conditioning in Long-Evans rats.

    Science.gov (United States)

    Mendoza, J; Sanio, C; Chaudhri, N

    2015-02-01

    The infralimbic medial prefrontal cortex (IL) has been posited as a common node in distinct neural circuits that mediate the extinction of appetitive and aversive conditioning. However, appetitive extinction is typically assessed using instrumental conditioning procedures, whereas the extinction of aversive conditioning is customarily studied using Pavlovian assays. The role of the IL in the extinction of appetitive Pavlovian conditioning remains underexplored. We investigated the involvement of the IL and prelimbic medial prefrontal cortex (PrL) in appetitive extinction in Pavlovian and instrumental conditioning assays in male, Long-Evans rats. Following acquisition, a gamma-aminobutyric acid agonist solution (0.03 nmol muscimol; 0.3 nmol baclofen; 0.3 μl/side) was bilaterally microinfused into the IL or PrL to pharmacologically inactivate each region before the first extinction session. Compared to saline, PrL inactivation did not affect the acquisition of extinction or the recall of extinction memory 24-h later. IL inactivation caused a more rapid extinction of Pavlovian conditioning, but had no effect on the extinction of instrumental conditioning or extinction recall. IL inactivation during a Pavlovian conditioning session in which conditioned stimulus (CS) trials were paired with sucrose did not affect CS-elicited behaviour, but increased responding during intervals that did not contain the CS. The same manipulation did not impact lever pressing for sucrose. These findings suggest that the IL may normally maintain Pavlovian conditioned responding when an anticipated appetitive CS is unexpectedly withheld, and that this region has distinct roles in the expression of Pavlovian conditioning when an appetitive unconditioned stimulus is either presented or omitted.

  10. Perilesional Inflammation in Neurocysticercosis - Relationship Between Contrast-Enhanced Magnetic Resonance Imaging, Evans Blue Staining and Histopathology in the Pig Model

    Science.gov (United States)

    Bustos, Javier A.; Calcina, Juan; Vargas-Calla, Ana; Suarez, Diego; Gonzalez, Armando E.; Chacaltana, Juan; Guerra-Giraldez, Cristina; Mahanty, Siddhartha; Nash, Theodore E.; García, Hector H.

    2016-01-01

    Background Disease manifestations in neurocysticercosis (NCC) are frequently due to inflammation of degenerating Taenia solium brain cysts. Exacerbated inflammation post anthelmintic treatment is associated with leakage of the blood brain barrier (BBB) using Evans blue (EB) staining. How well EB extravasation into the brain correlates with magnetic resonance imaging (MRI) using gadolinium (Gd) enhancement as a contrast agent and pericystic inflammation was analyzed in pigs harboring brain cysts of Taenia solium. Methodology/Principal Findings Three groups of 4 naturally infected pigs were assessed. The first and second groups were treated with both praziquantel plus albendazole and sacrificed two and five days post treatment, respectively. A third untreated group remained untreated. Pigs were injected with EB two hours prior to evaluation by Gd-enhanced T1-MRI, and euthanized. The EB staining for each cyst capsule was scored (EB grades were 0: 0%; 1: up to 50%; 2: over 50% but less than 100%; 3: 100%). Similarly, the Gd enhancement around each cyst was qualitatively and quantitatively scored from the MRI. The extent of pericystic inflammation on histology was scored in increasing severity as IS1, IS2, IS3 and IS4. Grade 3 EB staining and enhancement was only seen in treated capsules. Also, treated groups had higher Gd intensity than the untreated group. Grades of enhancement correlated significantly with Gd enhancement intensity. EB staining was correlated with Gd enhancement intensity and with IS4 in the treated groups. These correlations were stronger in internally located cysts compared to superficial cysts in treated groups. Significance EB staining and Gd enhancement strongly correlate. The intensity of enhancement determined by MRI is a good indication of the degree of inflammation. Similarly, EB staining highly correlates with the degree of inflammation and may be applied to study inflammation in the pig model of NCC. PMID:27459388

  11. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats.

    Science.gov (United States)

    Yamamoto, H; Watanabe, T; Mizuno, H; Endo, K; Fukushige, J; Hosokawa, T; Kazusaka, A; Fujita, S

    2001-01-01

    The Long-Evans Cinnamon (LEC) rats, due to a genetic defect, accumulate excess copper (Cu) in the liver in a manner similar to patients with Wilson's disease and spontaneously develop acute hepatitis with severe jaundice. In this study we examined the protective effect of DL-alpha-Lipoic acid (LA) against acute hepatitis in LEC rats. LA was administered to LEC rats by gavage in doses of 10, 30 and 100 mg/kg five times per week, starting at 8-weeks-old and continuing till 12-weeks-old. Although LA had little effect against the increases in serum transaminase activities, it suppressed the loss of body weight and prevented severe jaundice in a dose-dependent manner. Antioxidant system analyses in liver showed that LA treatment significantly suppressed the inactivations of catalase and glutathione peroxidase, and the induction of heme oxygenase-1, an enzyme which is inducible under oxidative stress. Furthermore, LA showed dose-dependent suppressive effect against increase in nonheme iron contents of both cytosolic and crude mitochondrial fractions in a dose-dependent manner. Although at the highest dose, LA slightly suppressed the accumulation of Cu in crude mitochondrial fraction, it had no effect on the accumulation of Cu in cytosolic fraction. While LA completely suppressed the increase in lipid peroxidation (LPO) in the microsomal fraction at the highest dose, the suppressive effect against LPO in crude mitochondrial fractions was slight. From these results, it is concluded that LA has antioxidant effects at the molecular level against the development of Cu-induced hepatitis in LEC rats. Moreover, mitochondrial oxidative damage might be involved in the development of acute hepatitis in LEC rats.

  12. Breeder and batch-dependent variability in the acquisition and performance of a motor skill in adult Long-Evans rats.

    Science.gov (United States)

    O'Bryant, Amber J; Allred, Rachel P; Maldonado, Monica A; Cormack, Lawrence K; Jones, Theresa A

    2011-10-10

    Reaching tasks are popular tools for investigating the neural mechanisms of motor skill learning and recovery from brain damage in rodents, but there is considerable unexplained variability across studies using these tasks. We investigated whether breeder, batch effects, experimenter, time of year, weight and other factors contribute to differences in the acquisition and performance of a skilled reaching task, the single pellet retrieval task, in adult male Long-Evans hooded rats. First, we retrospectively analyzed task acquisition and performance in rats from different breeding colonies that were used in several studies spanning a 3 year period in our laboratory. Second, we compared reaching variables in age-matched rats from different breeders that were trained together as a batch by the same experimenters. All rats had received daily training on the reaching task until they reached a criterion of successful reaches per attempt. We found significant breeder-dependent differences in learning rate and final performance level. This was found even when age-matched rats from different breeders were trained together by the same experimenters. There was also significant batch-to-batch variability within rats from the same breeder trained by the same experimenter. Other factors, including weight, paw preference and the experimenter, were not as strong or consistent in their contributions to differences across studies. The breeder and batch effects found within the same rat strain may reflect genetic and environmental influences on the neural substrates of motor skill learning. This is an important consideration when comparing baseline performance across studies and for controlling variability within studies.

  13. Perilesional Inflammation in Neurocysticercosis - Relationship Between Contrast-Enhanced Magnetic Resonance Imaging, Evans Blue Staining and Histopathology in the Pig Model.

    Directory of Open Access Journals (Sweden)

    Carla Cangalaya

    2016-07-01

    Full Text Available Disease manifestations in neurocysticercosis (NCC are frequently due to inflammation of degenerating Taenia solium brain cysts. Exacerbated inflammation post anthelmintic treatment is associated with leakage of the blood brain barrier (BBB using Evans blue (EB staining. How well EB extravasation into the brain correlates with magnetic resonance imaging (MRI using gadolinium (Gd enhancement as a contrast agent and pericystic inflammation was analyzed in pigs harboring brain cysts of Taenia solium.Three groups of 4 naturally infected pigs were assessed. The first and second groups were treated with both praziquantel plus albendazole and sacrificed two and five days post treatment, respectively. A third untreated group remained untreated. Pigs were injected with EB two hours prior to evaluation by Gd-enhanced T1-MRI, and euthanized. The EB staining for each cyst capsule was scored (EB grades were 0: 0%; 1: up to 50%; 2: over 50% but less than 100%; 3: 100%. Similarly, the Gd enhancement around each cyst was qualitatively and quantitatively scored from the MRI. The extent of pericystic inflammation on histology was scored in increasing severity as IS1, IS2, IS3 and IS4. Grade 3 EB staining and enhancement was only seen in treated capsules. Also, treated groups had higher Gd intensity than the untreated group. Grades of enhancement correlated significantly with Gd enhancement intensity. EB staining was correlated with Gd enhancement intensity and with IS4 in the treated groups. These correlations were stronger in internally located cysts compared to superficial cysts in treated groups.EB staining and Gd enhancement strongly correlate. The intensity of enhancement determined by MRI is a good indication of the degree of inflammation. Similarly, EB staining highly correlates with the degree of inflammation and may be applied to study inflammation in the pig model of NCC.

  14. Effects of Evans Blue and amiloride on anti-diuretic hormone (ADH)-induced sodium transport across frog (Rana hexadactyla) skin.

    Science.gov (United States)

    Jared, Silviya Rajakumari; Rao, Jonakuty Prakasa

    2013-05-01

    The epithelial sodium channel (ENaC) has four subunits, namely α (alpha), β (beta), γ (gamma) and δ (delta). The functional ENaC is formed by the combination of either αβγ or δβγ subunits. The aim of the present study is to determine the combination of ENaC subunits predominant on the apical side of the frog skin, and the effect of ADH on sodium transport though these two ENaCs subunit combinations. The ventral abdominal skin of the frog, Rana hexadactyla was mounted in an Ussing-type chamber. The voltage-clamp method was performed to measure the ionic transport across the frog skin with normal Ringer solution (NR) on both sides. Evans blue (300 µM) and amiloride (100 µM) were added to the NR on the apical side and ADH (40 nM) was added on the serosal side. Statistical significance was analyzed by Student's paired t-test and repeated-measures ANOVA, P < 0.05 was considered significant. This study suggests that the ENaC of the frog skin consist of both αβγ and δβγ subunit combinations on the apical side. Though both types of subunit combination are present, the αβγ type was found to be more common than δβγ. ADH increases the sodium transport across the frog skin. The effect of ADH on sodium transport is achieved through the combination of δ-subunits, not through the combination of a-subunits in the skin of Pana hexadactyla.

  15. Effect of magnesium ion supplementation on obesity and diabetes mellitus in Otsuka Long-Evans Tokushima Fatty (OLETF) rats under excessive food intake.

    Science.gov (United States)

    Nagai, Noriaki; Ito, Yoshimasa

    2013-01-01

    Several epidemiologic studies have found that magnesium ion (Mg²⁺) is related to obesity and type 2 diabetes mellitus. However, there have been almost no reports on the effects of a combination of excessive food intake and Mg²⁺ supplementation on metabolic syndrome and various blood tests values for diabetes mellitus. In this study, we investigated changes in body weight and blood test values for diabetes mellitus of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model for human type 2 diabetes mellitus via metabolic syndrome, under conditions of combined excessive food intake and Mg²⁺ supplementation. The rats received Mg²⁺ supplementation by drinking magnesium water (Mg²⁺; 200 mg/l). No significant differences were observed in the levels of food or water intake between OLETF rats drinking purified water (PW) or magnesium water (MW). Type 2 diabetes mellitus with metabolic syndrome developed at 30 weeks of age, and the body weights and plasma insulin levels of OLETF rats at 60 weeks of age were lower than those of normal rats. The plasma glucose (PG) levels in 38-week-old OLETF rats drinking MW were significantly lower than in those of rats drinking PW, while the body weights and the levels of triglycerides (TG) and insulin of 38-week-old MW-drinking OLETF rats were significantly higher than those of their PW-drinking counterparts. On the other hand, the decreases in body weight and insulin levels in 60-week-old OLETF rats were suppressed by MW supplementation. The present study demonstrates that Mg²⁺ supplementation delays the development of diabetes mellitus in OLETF rats under conditions of excessive food intake. In addition, obesity and high blood TG levels were observed in OLETF rats receiving Mg²⁺ supplementation in conjunction with excessive food intake.

  16. Decreased sexual motivation and heightened anxiety in male Long-Evans rats are correlated with the memory for a traumatic event.

    Science.gov (United States)

    Hawley, Wayne R; Grissom, Elin M; Belkin, Mark N; James, Thomas F; Dohanich, Gary P

    2013-05-01

    Individuals suffering from posttraumatic stress disorder (PTSD) frequently report disturbances in sexual functioning in addition to alterations in their affective behaviors. Notably, maladaptive cognitions and dysfunctional behaviors are perpetuated by the emergence of the intrusive thoughts that characterize the disorder. In rats, reminders of a traumatic event designed to simulate intrusive thoughts are associated with impairments in affective, social, and sexual behaviors. The current study examined the relationship between the memory for a traumatic event and changes in sexual and affective behaviors in male Long-Evans rats (N = 36). The trauma featured a combination stressor consisting of simultaneous exposure to a footshock and the odor of soiled cat litter. Memory for the trauma was reactivated by re-exposures to the context of the trauma in the absence of stressors and confirmed by assessing the percentage of time spent freezing. Following the second and final reminder, traumatized males exhibited reduced sexual motivation and increased anxiety, signified by longer latencies to achieve their first mount on a post-stress test of sexual behavior, and longer latencies to begin feeding in a novel environment, respectively. Correlational analyses revealed that decreased sexual motivation and heightened anxiety were predicted by the memory for the trauma as indicated by the time spent freezing during the re-exposures. The findings from the current study have implications for understanding the relationship between stress and sexual functioning and indicate that the impairments in sexual behavior that often occur in individuals with PTSD may be impacted by their memory for the trauma.

  17. El polisulfuro de calcio en el manejo de la moniliasis Moniliophthora roreri (Cif & Par. Evans et al. del cacao Theobroma cacao L.

    Directory of Open Access Journals (Sweden)

    Sandra Ramírez González

    2011-05-01

    Full Text Available El cacao es severamente afectado por el hongo Moniliophthora roreri (Cif & Par. Evans et al., el cual daña los frutos y puede ocasionar pérdidas totales y su control es principalmente cultural. El objetivo del trabajo es determinar la efectividad del polisulfuro de calcio (PC como alternativa para su manejo. El patógeno fue aislado y cultivado in vitro y se evaluó el efecto del PC sobre la germinación y formación de conidias; en el campo, sobre frutos se asperjó PC antes y después de la inoculación con M. roreri y se determinó la incidencia e índices de severidad interna y externa. En una plantación de cacao se asperjó PC y se determinó su incidencia y producción. El PC in vitro inhibió el crecimiento y la formación de conidias; la aplicación de PC antes o después de la inoculación artificial con M. roreri sobre frutos inhibe completamente el desarrollo de la enfermedad; con aspersiones de PC en plantaciones de cacao la incidencia de la enfermedad fue de 0,53%, mientras que fue de 21% con manejo cultural y del 69,6% con testigo de inoculación natural; la producción de cacao seco/año fue de un 90,6% más con PC que en el testigo de inoculación natural, por lo que resulta viable integrar PC en el manejo deM. roreri.

  18. Eesti Sisearhitektuur aastal 2007 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Eesti Kultuurkapitali arhitektuuri sihtkapitali ja Eesti Sisearhitektide Liidu 2006. a. preemiate laureaatidest ja nominentidest: Viimsi Keskkoolist (ESLi ühiskondliku ruumi preemia, H. Pihlak, K. Lents), restoranidest "Gianni" (P. Lausmäe) ja "Vertigo" (J. Roos, A. Labi), Foorumi kaubanduskeskusest (H. Praks, M. Tammik), Vene teatrist (A. Oja, R. Luuk), Koger &Partnerid büroost Fahle majas (ESLi ajaloolise intrejööri preemia, L. A. Tork), Skype'i büroost (arhitektuuri sihtkapitali sisearhitektuuri preemia, T. Piirmets) ning Velvet Creative Alliance (ESLi büroointerjööri preemia (T. Aunre) Tallinnas, Koordi mõisa peahoonest (R. Vaiksoo, K. Aren), diivanikompletist "Black" (ESLi esemepreemia, T. Mang), valgustitest "Saturn" ja "Mr. Note" (T. Luisk), lambiseeriast "Taara" (J. Roos, A. Labi)

  19. Eesti Sisearhitektuur aastal 2007 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Eesti Kultuurkapitali arhitektuuri sihtkapitali ja Eesti Sisearhitektide Liidu 2006. a. preemiate laureaatidest ja nominentidest: Viimsi Keskkoolist (ESLi ühiskondliku ruumi preemia, H. Pihlak, K. Lents), restoranidest "Gianni" (P. Lausmäe) ja "Vertigo" (J. Roos, A. Labi), Foorumi kaubanduskeskusest (H. Praks, M. Tammik), Vene teatrist (A. Oja, R. Luuk), Koger &Partnerid büroost Fahle majas (ESLi ajaloolise intrejööri preemia, L. A. Tork), Skype'i büroost (arhitektuuri sihtkapitali sisearhitektuuri preemia, T. Piirmets) ning Velvet Creative Alliance (ESLi büroointerjööri preemia (T. Aunre) Tallinnas, Koordi mõisa peahoonest (R. Vaiksoo, K. Aren), diivanikompletist "Black" (ESLi esemepreemia, T. Mang), valgustitest "Saturn" ja "Mr. Note" (T. Luisk), lambiseeriast "Taara" (J. Roos, A. Labi)

  20. Karakteriga kodu / Karen Jagodin ; kommenteerinud Enn Rajasaar

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    2008. aastal valminud 2-korruseline eramu Mähel. Arhitekt Enn Rajasaar. Sisearhitekt Aet Seire. Välisviimistluses on kombineeritud tumedat tellist ja heledat krohvi. Sisekujundust läbivad värvid punane ja must. Osa mööbliesemeid (raamatukapid, söögitoa laud) valmisid sisearhitekti erilahendusena

  1. Roostetav legomaja / Karen Jagodin ; kommenteerinud Laila Põdra

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Betoonelementidest eramu (267 m²) Tabasalus. Arhitekt Laila Põdra, insener Indrek Laul. Sisekujundus: Laila Põdra koos omanikega. Projekt: 2005-2007, valmis: 2008. Betoon on viimistluspinnaks ka interjööris. Läbivaks tooniks sise- ja välisviimistluses on roostepunane, teiseks põhitooniks on valge. Konkursil "Aasta Betoonehitis 2008" pälvis tellija eripreemia

  2. Noorte sisearhitektide leiutised Tallinna Disainigaleriis / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2005-01-01

    Eesti Kunstiakadeemia 2005. a. lõpetanud sisearhitektide diplomitööde väljapanekust Tallinnas Disaini- ja Arhitektuurigaleriis juunis 2005. Linda Anstali, Elo Liina Kaivo, Helen Rebase, Maris Kerge, Mari Tosmini, Triinu Kuub'i, Kaarel Künnapu, Kard Männili, Kärt Kukkuri, Karmen Vettiku ja Galina Burnakova diplomitöödest

  3. Välismaa arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Jean Nouveli projekteeritud 142 m kõrgune hoone Barcelonas. Sotsiaalmajad Madridis. Villa Berliinis (Pott Arhitektid). Kortermaja Amsterdamis (arhit. büroo MVRDV). Trammide ootepaviljon Alicantes Hispaanias

  4. Värskeid noppeid Kopenhaagenist / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Orestadist, mida asuti kavandama 1992. a. Korterelamust VM Huset (büroode PLOT+BIG+JDS ühistöö). Silotornidest rekonstrueeritud korterelamutest (Hollandi büroo MVRDV, Taani büroo JJW Arkitekter), kus korterid on ehitatud torni välisseinte külge. Tietgeni ühiselamust (Lundgaard & Tranberg), mis on esitatud 2007. a. Mies van der Rohe arhitektuuriauhinna nominendiks

  5. Hispanos en la EPA: Karen Milians

    Science.gov (United States)

    La diversidad de la fuerza laboral es importante para la Agencia de Protección Ambiental de EE.UU. (EPA, por sus siglas en inglés). Los empleados hispanos de la EPA contribuyen diariamente hacia la protección de la salud y el medio ambiente.

  6. Roostetav legomaja / Karen Jagodin ; kommenteerinud Laila Põdra

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Betoonelementidest eramu (267 m²) Tabasalus. Arhitekt Laila Põdra, insener Indrek Laul. Sisekujundus: Laila Põdra koos omanikega. Projekt: 2005-2007, valmis: 2008. Betoon on viimistluspinnaks ka interjööris. Läbivaks tooniks sise- ja välisviimistluses on roostepunane, teiseks põhitooniks on valge. Konkursil "Aasta Betoonehitis 2008" pälvis tellija eripreemia

  7. Välismaa arhitektuuriuudised / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Jean Nouveli projekteeritud 142 m kõrgune hoone Barcelonas. Sotsiaalmajad Madridis. Villa Berliinis (Pott Arhitektid). Kortermaja Amsterdamis (arhit. büroo MVRDV). Trammide ootepaviljon Alicantes Hispaanias

  8. Noorte sisearhitektide leiutised Tallinna Disainigaleriis / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2005-01-01

    Eesti Kunstiakadeemia 2005. a. lõpetanud sisearhitektide diplomitööde väljapanekust Tallinnas Disaini- ja Arhitektuurigaleriis juunis 2005. Linda Anstali, Elo Liina Kaivo, Helen Rebase, Maris Kerge, Mari Tosmini, Triinu Kuub'i, Kaarel Künnapu, Kard Männili, Kärt Kukkuri, Karmen Vettiku ja Galina Burnakova diplomitöödest

  9. Karakteriga kodu / Karen Jagodin ; kommenteerinud Enn Rajasaar

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    2008. aastal valminud 2-korruseline eramu Mähel. Arhitekt Enn Rajasaar. Sisearhitekt Aet Seire. Välisviimistluses on kombineeritud tumedat tellist ja heledat krohvi. Sisekujundust läbivad värvid punane ja must. Osa mööbliesemeid (raamatukapid, söögitoa laud) valmisid sisearhitekti erilahendusena

  10. Obituary: Lynne Karen Deutsch, 1954-2004

    Science.gov (United States)

    Sprague, Ann L.

    2004-12-01

    It is with deep sadness and regret that we note the passing of our dear friend and colleague Prof. Lynne K. Deutsch. Lynne died on 2 April 2004 after a protracted illness and lengthy battle with complications caused by the blood disease Polycythaemia Vera. Lynne was born in Chicago on 26 November 1956 to Victor and Ailsa Deutsch. She lived with her family in the town of Morton Grove, IL until she was 8 years old, when they moved to Beverly Hills, CA. She was an outgoing child who played basketball and excelled in her studies. She graduated from Beverly Hills High School at the age of 16 after completing all high school requirements in only three years. Lynne had a beautiful singing voice, and was in the chorus in high school and college. Lynne earned her first bachelor's degree in philosophy from the University of California at Berkeley in 1977. She then returned to Berkeley and received a second bachelor's degree, this time in physics, in 1981. She was a graduate student and teaching assistant at MIT and earned an MS in physics from MIT in 1983. Lynne then attended the astronomy graduate program at Harvard University, where she earned her MA in 1985 and PhD in 1990. During her degree studies she began crafting mid-infrared instrumentation. These instruments were destined to be used by a host of eager observers to discover, identify, and study many emissions from the Solar System, and galactic and extragalactic sources. Lynne was a National Research Council Post-doctoral Fellow at NASA Ames Research Center from 1990 - 1992, where she played an important role in the development of the Smithsonian Astrophysical Observatory/University of Arizona Mid-Infrared Array Camera (MIRAC), a well-known and much sought after instrument frequently used in studies of Mercury, Jupiter, the Moon, planetary nebulae, star formation regions, galactic center, young stellar objects, and extragalactic objects. After leaving NASA Ames Research Center, Lynne taught for several years (1993-96) at Smith College where she had a significant impact on undergraduate research, especially for women, whom she enjoyed mentoring. Lynne joined the faculty in the Astronomy Department of Boston University in 1996 where she taught instrumentation principles and techniques to undergraduate and graduate students. Over the course of her faculty career, she received numerous research grants and fellowships that were used to support her research, her students, and her postdoctoral associates. She was the principal investigator of Boston University's advanced technologies and instrumentation program MIRABU: A Mid-Infrared Array. As her health declined and the rigors of a full teaching schedule became unacceptably taxing, Lynne took a leave of absence from Boston University and returned to Harvard University and the Center for Astrophysics in 2001. There she became a very active member of the Infrared Group in the OIR Division and a member of the IRAC/Spitzer Space Telescope team. Her research in infrared astronomy covered many areas including star formation, planetary and protoplanetary nebulae, solar system objects, the interstellar medium and infrared-luminous galaxies. Her most recent research with the Infrared Array Camera (IRAC) on the Spitzer Space Telescope concentrated on high-mass star formation and the related evolution of the interstellar medium. In her short life, Lynne made many devoted friends and colleagues and was active in encouraging school-age girls to pursue their interests in the sciences. In her short career, she published more than seventy-five articles. She was an outstanding observer and instrumentalist, whose promising career was tragically cut short. Lynne was also a devoted mother and wife, and, while still well, she found the time to be an active participant in her son's elementary school. She is very greatly missed by her family. She is survived by her husband Douglas Sondak, PhD and her son Reed Deutsch-Sondak who live in Acton, MA, and her parents and sister Judith who reside in California. Lynne will be forever missed by her family, friends, colleagues, and the astronomical community. Her contributions will continue to benefit the community for many years to come. We only wish she were here to share them with us. She will be remembered as a dear friend, colleague, accomplished scientist, and dedicated family member.

  11. Liiga palju raha / Karen Lowry Miller

    Index Scriptorium Estoniae

    Miller, Karen Lowry

    2003-01-01

    Ilmunud ka: Spekter (vene k.) nr. 2, lk. 20-23. Autor kirjeldab, kuidas investorid rahanappusest üleküllusesse sattunud maailmas pidevalt uusi investeerimisvõimalusi otsivad ja juhib tähelepanu investorite poolt tekitatud majandusbuumides peituvatele ohtudele. Kaart: Seebimullide maakaart. Diagrammid: Raha kasvab kiiremini; Ülemaailmselt liikuv kapital

  12. Vaidlus vananemise üle / Karen Weintraub

    Index Scriptorium Estoniae

    Weintraub, Karen

    2011-01-01

    Sirtris Pharmaceuticals, kes tegeleb vananemisvastaste uuringute läbiviimise ja vastavatoimeliste medikamentide väljatöötamisega, on suurt tähelepanu pälvinud vanamisvastaseid geene mõjutavate ensüümide sirtuiinide leidmisega. Lühidalt ka ratamütsiini eluiga pikendava toime mehhanismist

  13. Vintage-puudutusega korter / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2012-01-01

    Tallinna kesklinna kivist kortermajas 2011. aastal valminud korteris on koha leidnud Skandinaaviamaade 1950.-1960. aastate peenikeste jalgadega disainmööbel. Vineerist raamaturiiuli kavandas disainer Veiko Liis

  14. Arhitektuurivõistlused 2007 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Tulemused: Eesti Rahvusringhäälingu hoone arhitektuurse idee konkurss (I - E. Nobel), Paide kutsekeskkoolide uue hoonekompleksi arhitektuurivõistlus (I - M. Tüür, V. Tomiste, O. Kadarik, Kosmos), Prantsuse Lütseumi spordihoone ideekonkurss (I - T. Laigu, K. Ojaliiv, M. Rass, EMP A&I), Volta kvartali kutsutud osalejatega ideevõistlus (I - AW2 Arkkitehtit), aasta betoonehitis 2006 - Luku-Experdi büroohoone (H. Kesler), Eesti Vabadussõja võidusamba võistlus (I - R. Sternfeld, A. Laidre, K. Kiho, A. Savi), Tabasalu alevikukeskuse hoonestuse kutsutud osalejatega ideevõistlus (I - T. Laigu, K. Ojaliiv, QP Arhitektid), Tamsalu linna keskosa ruumilise planeerimise avalik arhitektuurivõistlus (I - T. Skolimowski, K. Süda, A. Vaher, R. Parve, ASE), Eesti Vabaõhumuuseumi külastuskeskuse, ennistuskoja Kanut ja Tallinna muuseumide ühishoidla arhitektuurse idee võistlus (I - S. Vallner, I. Peil), Patarei ja lennusadama ala mahulise planeerimise rahvusvaheline ideevõistlus (I - I. Lubjak, S. Laanjärv), parim puitehitis 2007 - eramu Kiili vallas (K. Tõra, A. Sokk, T. Peipman), Keila Tuula tee 5 planeeringu võistlus (I - A. Uogintas, M. Podagelyte, M. Cirtautas)

  15. Arhitektuurivõistlused 2007 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Tulemused: Eesti Rahvusringhäälingu hoone arhitektuurse idee konkurss (I - E. Nobel), Paide kutsekeskkoolide uue hoonekompleksi arhitektuurivõistlus (I - M. Tüür, V. Tomiste, O. Kadarik, Kosmos), Prantsuse Lütseumi spordihoone ideekonkurss (I - T. Laigu, K. Ojaliiv, M. Rass, EMP A&I), Volta kvartali kutsutud osalejatega ideevõistlus (I - AW2 Arkkitehtit), aasta betoonehitis 2006 - Luku-Experdi büroohoone (H. Kesler), Eesti Vabadussõja võidusamba võistlus (I - R. Sternfeld, A. Laidre, K. Kiho, A. Savi), Tabasalu alevikukeskuse hoonestuse kutsutud osalejatega ideevõistlus (I - T. Laigu, K. Ojaliiv, QP Arhitektid), Tamsalu linna keskosa ruumilise planeerimise avalik arhitektuurivõistlus (I - T. Skolimowski, K. Süda, A. Vaher, R. Parve, ASE), Eesti Vabaõhumuuseumi külastuskeskuse, ennistuskoja Kanut ja Tallinna muuseumide ühishoidla arhitektuurse idee võistlus (I - S. Vallner, I. Peil), Patarei ja lennusadama ala mahulise planeerimise rahvusvaheline ideevõistlus (I - I. Lubjak, S. Laanjärv), parim puitehitis 2007 - eramu Kiili vallas (K. Tõra, A. Sokk, T. Peipman), Keila Tuula tee 5 planeeringu võistlus (I - A. Uogintas, M. Podagelyte, M. Cirtautas)

  16. Ettevõtluskeskkonna uuring / Karen Veidik

    Index Scriptorium Estoniae

    Veidik, Karen

    2003-01-01

    AS Ülo Siinmaa Grupp viis koostöös aktiivsete tudengitega erinevatest kõrgkoolidest läbi ettevõtluskeskkonna uuringu. Oma osalemisest räägivad ka kaks EBS-i üliõpilast Astrid Raja ja Gerli Sirk

  17. Vaidlus vananemise üle / Karen Weintraub

    Index Scriptorium Estoniae

    Weintraub, Karen

    2011-01-01

    Sirtris Pharmaceuticals, kes tegeleb vananemisvastaste uuringute läbiviimise ja vastavatoimeliste medikamentide väljatöötamisega, on suurt tähelepanu pälvinud vanamisvastaseid geene mõjutavate ensüümide sirtuiinide leidmisega. Lühidalt ka ratamütsiini eluiga pikendava toime mehhanismist

  18. 西北地区赫刺螨亚科和鼠刺螨亚科小志%Small-sinica of Hirstionyssinae Evans et Till and Myonyssinae Tiraboschi in northwest China

    Institute of Scientific and Technical Information of China (English)

    刘增加; 张继军

    2011-01-01

    目的 研究西北地区厉螨科的种类与地理分布.方法 宿主体检螨法、巢穴检螨法和文献资料收集.结果 记述了西北地区赫刺螨亚科和鼠刺螨亚科2亚科2属28种:其中赫刺螨亚科1属27种,赫刺螨属27种;鼠刺螨亚科1属1种,鼠刺螨属1种.结论 明确了西北地区赫刺螨亚科和鼠刺螨亚科的种类与分布,为深入研究与防控提供了科学依据.%Objective To study features of species and the geographical distribution of Laelapidae Berlese in northwest China.Methods Using the methods of mite inspection of host surface and nest.Results Hirstionyssinae Evans et Till and Myonyssinae Tiraboschi in the northwest China belonging to 2 genera and a total of 28 species had been recorded, of which 27 species of Genus Hirstionyssus Fonseca in Hirstionyssinae Evans et Till and 1 species of Genus Myonyssus Tiraboschi in Myonyssinae Tiraboschi of Laelapidae Berlese.Conclusion The results provide scientific basis for more study and preventing and controlling by grasping Hirstionyssinae Evans et Till and Myonyssinae Tiraboschi of Laelapidae Berlese in the northwest China.

  19. In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning

    Energy Technology Data Exchange (ETDEWEB)

    Gallagher, M. [Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC (United States); Bizon, J.L. [Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC (United States); Nicolle, M.M. [Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC (United States)

    1996-08-02

    Using in vitro autoradiography, we investigated [{sup 3}H]{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, [{sup 3}H]kainate and [{sup 3}H]N-methyl-d-aspartate binding in two forebrain regions, the hippocampus and striatum, of young (four months of age) and aged (24-25 months of age) Long-Evans rats that had previously been tested for spatial learning ability in the Morris water maze. Although there was substantial preservation of binding in the aged rats, reductions in binding were present in the aged rats that were specific to ligand and anatomical region. In the hippocampus of aged rats, [{sup 3}H]{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate binding in CA1 and [{sup 3}H]kainate binding in CA3 were reduced. In contrast, N-methyl-d-aspartate binding was not significantly different between age groups. There was evidence of sprouting in the dentate gyrus molecular layer of aged rats, indicated by changes in the topography of [{sup 3}H]kainate binding. Binding density was analysed with respect to patch/matrix compartmentalization in the striatum. The most striking result was a large decrease in N-methyl-d-aspartate binding in aged rats that was not limited to any dorsal/ventral or patch/matrix area of the striatum. Additionally, [{sup 3}H]kainate binding in striatal matrix was modestly reduced in aged rats. Of these age effects, only N-methyl-d-aspartate binding in the striatum and [{sup 3}H]kainate binding in the CA3 region of the hippocampus were correlated with spatial learning, with lower binding in the aged rats associated with better spatial learning ability.Age-related alterations in ionotropic glutamate receptors differ with respect to the receptor subtype and anatomical region examined. The age effects were not neccessarily indicative of cognitive decline, as only two age-related binding changes were correlated with spatial learning. Interestingly, in these instances, lower binding in the aged rats was associated with preserved spatial

  20. Operant self-administration of sweetened ethanol and time course of blood ethanol levels in adolescent and adult male Long-Evans rats.

    Science.gov (United States)

    Doherty, James M; Gonzales, Rueben A

    2015-03-01

    Little is known regarding mechanisms regulating ethanol (EtOH) self-administration during adolescence or if the mechanisms differ from adults. One of the best models of abuse liability is operant self-administration. Therefore, we characterized operant sweetened EtOH self-administration behavior in adolescent and adult rats. Adolescent (36 days old at first EtOH exposure) and adult male Long-Evans rats were first trained to self-administer 10% sucrose (10S) in an appetitive/consummatory operant model for 1 week, and then the drinking solution was switched to 10% sucrose plus 10% EtOH (10S10E) for 2 weeks. Next, rats were switched to a fixed ratio 2 schedule, and this was followed by 1 session using a progressive ratio schedule of reinforcement. Last, rats were tested for cue-induced reinstatement of lever-pressing behavior under extinction conditions after 13 days of abstinence. Blood EtOH concentration (BEC) of sweetened EtOH (self-administered or intragastric [IG] administration of 1 g/kg) was determined via gas chromatography. Control rats drank only 10S. Consumption of sweetened EtOH was not different between adolescents and adults under any schedule tested, reaching 1 g/kg in 20 minutes in the appetitive/consummatory model. Appetitive behavior directed at sweetened EtOH was less focused in adolescents versus adults. No age differences were found in motivation for sweetened EtOH. Cue-induced reinstatement of EtOH-seeking behavior after abstinence also did not differ by age. In control groups, no age difference was found in appetitive behavior or the amount of sucrose consumed, although adults exhibited greater cue-induced reinstatement. BEC after self-administration or IG administration of sweetened EtOH was higher in adults than adolescents. Consumption and motivation for sweetened EtOH are similar in adolescents and adults, although adolescents are more vulnerable to the effects of EtOH consumption on appetitive behavior. The IG results suggest larger volume

  1. Assessment of ZnO and SiO2 nanoparticle permeability through and toxicity to the blood-brain barrier using Evans blue and TEM.

    Science.gov (United States)

    Shim, Kyu Hwan; Jeong, Kyeong-Hoon; Bae, Sun Oh; Kang, Min O; Maeng, Eun Ho; Choi, Cheol Soo; Kim, Yu-Ri; Hulme, John; Lee, Eun Kyu; Kim, Meyoung-Kon; An, Seong Soo A

    2014-01-01

    As increasing variants of nanoparticles (NPs) are being used in various products, it has become apparent that size alone can no longer adequately explain the variety of generated toxic profiles. Recent studies with NPs have suggested that various sizes of NPs could determine in vitro toxicity. In an attempt to address concerns regarding neurotoxicity of zinc oxide (ZnO) and silica (SiO2) NPs, these were examined after exposing them via oral, dermal, and intravenous administrations of NPs and their toxicological effects on the brain over a prescribed period of time were assessed. After 28 days of repeated oral administrations of ZnO or SiO2 independently, possibly due to damages to the blood brain barrier (BBB), neurotoxicity, were investigated by Evans blue technique. Next, in order to assess whether ZnO NPs could compromise the BBB, ZnO NPs were intravenously injected on day 0, 7, 14, 21 and 28 no further treatment was administered for 62 days. Deposition of SiO2 in brain from repeated dermal and oral administrations for 90 days were evaluated by transmission electron microscopy coupled with scanning energy-dispersive X-ray spectroscopy. Physiochemical profiles were principally determined on particle size at the beginning of the current toxicity investigations on ZnO and SiO2 NPs. The BBB was found to be intact after independent repeated oral administrations of ZnO or SiO2 NPs for 28 days, suggesting no significant damage. Neuronal death was also not observed after the intravenous administrations of ZnO NPs. After 90 days of repeated dermal and oral administration of SiO2 NPs, no deposition of NPs was observed in hippocampus, striatum, and cerebellum regions using transmission electron microscope analyses. These observations suggest that the BBB was not compromised and was able to block penetration of ZnO and SiO2 NPs, resulting in significant neurotoxic effects. Moreover, absence of SiO2 in three regions of brain after dermal and oral administrations for 90 days

  2. Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring.

    Science.gov (United States)

    Salazar, Veronica; Castillo, Carmen; Ariznavarreta, Carmen; Campón, Rocío; Tresguerres, Jesús A F

    2004-12-01

    To investigate the influence of dibutyl phtalate (DBP) given in a soy-free rat chow on pre-pubertal development, 46 Long Evans female rats 2-month-old were divided into three experimental groups and fed three different chows: (1) control; (2) DP 0.61 g/kg chow (12 mg/kgrat/day); (3) DP 2.5 g/kg chow (50 mg/kg rat/day) for 2 months. While under this treatment, they were mated and their offspring studied. Litter size and female:male ratio were recorded. At 14 days of age 6, male pups of each group were sacrificed and testis and thymus were excised and weighed. Pups were weaned at 22 days of age and continued into three experimental groups according to diet. From day 22 onwards, vaginal opening, occurrence of first estrous, and pre-putial separation were recorded. The percent of pregnancies showed a marked decrease in group 3, while no difference was observed between groups 1 and 2. Sex prevalence and litter size were not affected by the different diets. Pup survival showed a decrease when mothers were fed diet 2, but it was similar in diets 1 and 3. Pup weights on day 2 showed an evident (P < 0.05) reduction in groups 2 and 3, the decrease being more marked (P < 0.001) in group 3. On day 6, pups of group 2 showed lower weights (P < 0.01) as compared with the other groups. Weight gain was significantly higher in pups of group 3. Eye opening was not affected by the different diets. Fourteen-day-old male pups' relative weight of thymus and testis showed a decrease in animals whose mothers had been fed diets 2 and 3. Vaginal opening and occurrence of first estrous showed an evident delay (P < 0.05; P < 0.01) in females fed diets 2 and 3. Significant differences (P < 0.001) in pre-putial separation were observed between treated and untreated groups. Offspring pre-pubertal development seems to be affected by oral intake of DBP by their mothers during pregnancy, the effects being more evident in the reproductive development of male pups.

  3. Hair breakage by combing and brushing--a comment on: T. A. Evans and K. Park, A statistical analysis of hair breakage. II. Repeated grooming experiments, J. Cosmet. Sci., 41, 439-456 (2010).

    Science.gov (United States)

    Kamath, Y K; Robbins, C

    2011-01-01

    Literature dealing with the mechanisms of hair breakage in combing and brushing published so far has been reviewed as a background for the critical evaluation of the method and data analysis of the paper "Statistical Analysis of Hair Breakage. II" by Evans and Park (1). Accumulated knowledge about hair breakage in these grooming processes indicates that hair breakage in combing and brushing results from tangling, looping, knotting, and impact loading. Fatiguing, though responsible for some weakening of the fiber in the grooming process, it is unlikely to be a significant factor in hair breakage in combing and brushing.

  4. Niebiali, niemężczyźni i inni nieprawdziwi obywatele. O reprodukcji społecznych nierówności w książce Karen Brodkin „How Jews Became White Folks and What That Says about Race in America”

    Directory of Open Access Journals (Sweden)

    Agnieszka Pasieka

    2014-06-01

    Full Text Available Non-whites, non-males and other non-genuine citizens. The reproduction of social inequalities as seen in Karen Brodkin’s 'How Jews Became White Folks and What That Says about America' The article offers a review of Karen Brodkin’s How Jews Became White Folks and What That Says about America. Brodkin analyses the social and political transformations in America and puts the analysis in the context of her own autobiography. The first issue that Brodkin investigates are the processes that led to the change in the social status of Jews and other immigrants from Eastern and Southern Europe in the 20th century. Second, Brodkin tries to understand her own origins, as well as different life styles and ways of perceiving the Jewish identity present in her family. Beside the analysis itself, Brodkin also offers many interesting remarks on the construction of racial and ethnic categories, discrimination, and the interactions between the ethnic, class and gender aspects of one’s identity.   Niebiali, niemężczyźni i inni nieprawdziwi obywatele. O reprodukcji społecznych nierówności w książce Karen Brodkin „How Jews Became White Folks and What That Says about Race in America” Artykuł ten stanowi recenzję książki amerykańskiej antropolożki Karen Brodkin, zatytułowanej How Jews Became White Folks and What That Says about Race in America (‘Jak Żydzi stali się białymi i co mówi to o zjawisku rasy w Ameryce’, która łączy analizę przemian społeczno-politycznych w Stanach Zjednoczonych z autobiograficznym studium własnych doświadczeń autorki. Tym samym Brodkin podejmuje dwa zasadnicze problemy. Pierwszym z nich jest próba zrozumienia procesów, które doprowadziły do zmiany statusu społecznego Żydów oraz innych imigrantów ze wschodniej i południowej Europy w dwudziestowiecznej Ameryce. Drugą analizowaną kwestią jest próba zrozumienia przez autorkę jej własnego pochodzenia, sytuacji rodzinnej, obowiązujących w

  5. ‘Historical narratives and historical desires: re-evaluating American art criticism of the mid-nineteenth century’: Karen Georgi, Critical Shift: Rereading Jarves, Cook, Stillman, and the Narratives of Nineteenth-Century American Art, The Pennsylvania State University Press, 2013

    Directory of Open Access Journals (Sweden)

    Emily Gephart

    2014-12-01

    Full Text Available Striving to distinguish their authority as and demonstrate their professionalism, art critics James Jackson Jarves, Clarence Cook, and William James Stillman wrote exhibition reviews, essays, and increasingly self-conscious histories of American art and artists in the mid-nineteenth century. Whereas their writing has often been employed to establish a model of opposed pre- and post-war periodization in American art, Karen Georgi challenges this view, re-evaluating the rhetorical structures through which they set forth their opinions. Despite apparent differences and transformations in their categorical classifications, she finds commonalities in their definitions of art, as well as deeper commitments to the enduring belief in art’s truthfulness, and its moral and didactic purpose.

  6. Antihyperglycemic, insulin-sensitivity and anti-hyperlipidemic potential of Ganoderma lucidum, a dietary mushroom, on alloxan- and glucocorticoid-induced diabetic Long-Evans rats

    Directory of Open Access Journals (Sweden)

    Md. Moklesur Rahman Sarker

    2015-12-01

    Full Text Available Background: Reishi (Ganoderma lucidum is a well-known and popular edible mushroom eaten as vegetables all over the world. It has been used as alternative medicine for long years in China, Korea, Japan, Malaysia, and in eastern Russia. It is reported to exhibit a number of medicinal properties including antitumor, antioxidant, immunomodulating, anti-inflammatory, hepatoprotective, and hypoglycemic activities due to the presence of bioactive polysaccharide. Glucocorticoids, prescribed for the treatment of arthritis to protect inflammation and reduce pain, can induce hyperglycemia or aggravate the hyperglycemic condition reaching to very high glucose levels in diabetic patients. However, no report has been published for its activity on glucocorticoid-induced diabetes. Objective: To investigate the effect of Ganoderma lucidum on alloxan- and glucocorticoid- induced diabetes in Long-Evans rats. Methods: Alloxan monohydrate (150 mg/kg was intraperitoneally administered to Long-Evans rats as a single dose. The same volume of normal saline was injected to control rats. Three days after alloxan injection, rats with plasma glucose levels higher than 12 mmoL /L were considered as diabetic and they were included in the study. Reishi mushroom was collected from the Mushroom Development Institute, Ministry of Agriculture, Savar, Dhaka, Bangladesh, where it was identified by a Taxonomist. Petroleum ether extract (PEE Methanol extract (ME were prepared by maceration and distillation techniques. The extracts were orally administered once in a day at doses of 200, 400, 600 and 800 mg/kg, respectively for 7 days. Metformin (150 mg/kg was orally administered as a standard antidiabetic drug. Glucose levels were measured at 0 and 7th days of treatment. The rats were allowed to rest for 1 week without treatment. The animals were again injected with dexamethasone (2 mg/kg through intra-muscular route for 3 days and glucose levels were monitored regularly. Rats were

  7. Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action.

    Science.gov (United States)

    Vaidya, A H; Rosenthal, D I; Lang, W; Crooke, J J; Benjamin, D; Ilyin, S E; Reitz, A B

    2005-05-01

    Most studies concerning the effects of oral buspirone in the rat elevated plus-maze (EPM) test, spontaneous motor activity (SMA) test, and Vogel conflict (VC) test have used Sprague-Dawley or Wistar rats. Although it has been documented that the behavior of Long-Evans rats is more sensitive to detection of anxiolytics when compared to the aforementioned strains, the effects of oral buspirone have not been fully characterized in the Long-Evans strain in the EPM and VC tests. Thus, we studied the effects of orally administered buspirone (0.03-10.0 mg/kg) in the EPM, SMA, and VC (0.3-60.0 mg/kg) tests in Long-Evans rats. In a separate experiment, brain and plasma concentrations of buspirone and 1-(2-pyrimidinyl)-piperazine (1-PP) were determined after oral administration of buspirone (0.3 and 10 mg/kg) to relate the behavioral effects of buspirone with brain and plasma concentrations of buspirone and 1-PP. Our results showed that buspirone exhibited an inverted-U-shaped dose-response curve in both the EPM and the VC tests. In the EPM, buspirone produced anxiolytic activity in a low, narrow dose-range (0.03, 0.1, 0.3 mg/kg, p.o.) with maximum efficacy at 0.3 mg/kg, whereas in the VC test, significant anxiolytic activity was observed in a high, narrow dose-range (10, 30 mg/kg, p.o.) with maximum efficacy occurring at 10 mg/kg. In the SMA test, buspirone (10 mg/kg, p.o.) significantly decreased horizontal activity and vertical movements suggestive of sedation. Also, one hour following oral doses of buspirone (0.3 and 10 mg/kg), both buspirone and 1-PP concentrations were higher in brain when compared with those in plasma. Additionally, the concentrations of 1-PP were always higher in brain and in plasma compared with the concentrations of buspirone. Of particular interest is our finding of the shift in the dose-response curve between the EPM and VC tests. This shift in the dose-response curve is discussed in relation to brain levels of buspirone and 1-PP levels and their

  8. University of Geneva honours LHC project leader Lyn Evans at 450th anniversary ceremony. The honorary degrees, which recognize endeavours in human rights and in fostering dialogue between nations, were also awarded to Mary Robinson, Desmond Tutu, as well as Pascal Lamy .

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    University of Geneva honours LHC project leader Lyn Evans at 450th anniversary ceremony. The honorary degrees, which recognize endeavours in human rights and in fostering dialogue between nations, were also awarded to Mary Robinson, Desmond Tutu, as well as Pascal Lamy .

  9. Investigation of Metabolism of Exogenous Glucose at the Early Stage and Onset of Diabetes Mellitus in Otsuka Long-Evans Tokushima Fatty Rats Using [1, 2, 3-13C]Glucose Breath Tests.

    Science.gov (United States)

    Kawagoe, Naoyuki; Kano, Osamu; Kijima, Sho; Tanaka, Hideki; Takayanagi, Masaaki; Urita, Yoshihisa

    2016-01-01

    This study aimed to evaluate changes in glucose metabolism at the early stage and onset of diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Specifically, after the oral administration of [1, 2, 3-13C]glucose, the levels of exhaled 13CO2, which most likely originated from pyruvate decarboxylation and tricarboxylic acid, were measured. Eight OLETF rats and eight control rats (Long-Evans Tokushima Otsuka [LETO]) were administered 13C-glucose. Three types of 13C-glucose breath tests were performed thrice in each period at 2-week intervals. [3-13C]glucose results in a 13C isotope at position 1 in the pyruvate molecule, which provides 13CO2. The 13C at carbons 1 and 2 of glucose is converted to 13C at carbons 2 and 1 of acetate, respectively, which produce 13CO2. Based on metabolic differences of the labeled sites, glucose metabolism was evaluated using the results of three breath tests. The increase in 13CO2 excretion in OLETF rats was delayed in all three breath tests compared to that in control rats, suggesting that OLETF rats had a lower glucose metabolism than control rats. In addition, overall glucose metabolism increased with age in both groups. The utilization of [2-13C]glucose was suppressed in OLETF rats at 6-12 weeks of age, but they showed higher [3-13C]glucose oxidation than control rats at 22-25 weeks of age. In the [1-13C]glucose breath test, no significant differences in the area under the curve until 180 minutes (AUC180) were observed between OLETF and LETO rats of any age. Glucose metabolism kinetics were different between the age groups and two groups of rats; however, these differences were not significant based on the overall AUC180 of [1-13C]glucose. We conclude that breath 13CO2 excretion is reduced in OLETF rats at the primary stage of prediabetes, indicating differences in glucose oxidation kinetics between OLETF and LETO rats.

  10. 新生Long Evans大鼠初级视皮层神经元的培养和鉴定%Identification and culture of visual cortex neurons in newborn Long Evans rats

    Institute of Scientific and Technical Information of China (English)

    姚军平; 侯文生; 刘慧; 陈丽峰; 阴正勤

    2012-01-01

    目的 建立新生Long Evans大鼠视皮层神经元原代培养方法.方法 采用钝性分离1d龄Long Evans大鼠双侧视皮层,2.5 g· L-1胰蛋白酶消化法获得细胞悬液,在无血清培养基中进行培养,7~14d后行免疫组织化学及膜片钳鉴定.结果 用该方法培养的视皮层神经细胞存活率高,生长状态良好,存活可达1个月左右,β-Ⅲ tubulin免疫组织化学染色阳性神经元占培养细胞中的80%以上,膜片钳成功记录了180个细胞,静息膜电位在- 50 ~ - 70 mV,存在内向、外向电流,脉冲恒流刺激可诱发多个动作电位.结论 本研究所采用的分离及原代培养方法是一种简单、高效的视皮层神经元培养方法.%Objective To establish the protocol for culturing visual cortex neurons derived from newborn Long Evans rats in vitro. Methods Tissues from visual cortex of one day aged Long Evans rats were harvested and digested into cell suspension by 2. 5 g · L-1 trypsogen. Those cells were then cultured with serum free medium, the cultured cells were identified by immunochemical staining and patch clamp recording after cultured from 7 days to 14 days. Results The neurons from visual cortex had high survival rate and good conditions during growth, some cells could survive one month. The positive cells staining of β-III tubulin were more than 80% ,180 cultured visual cortex neurons were successful recorded by patch clamp, the resting membrane potentials were between -50 mV and -70 mV, inward current and outward current were existed, several action potentials could be elicited by constant current stimulation. Conclusion This method is simple and effective for the culture of visual cortex neurons.

  11. Utilidad de la Técnica de inmunofluorescencia indirecta en ratas Long Evans nutridas, desnutridas, infectadas con T. spiralis e inmunizadas con el inmunógeno de 45kDa

    Directory of Open Access Journals (Sweden)

    M. en C. José Jesús Muñoz Escobedo

    2011-02-01

    Full Text Available ResumenLa Trichinellosis es una zoonosis endémica, cosmopolita, sus huéspedes son: rata, cerdo y otros mamíferos entre ellos el hombre, la presencia de Trichinellosis se debe a la ingestión de carne de cerdo insuficientemente cocida, afecta a países con bajos recursos económicos. Se han caracterizado Inmunógenos, siendo el inmunodominante el de 45 kDa, efectivo contra T. spiralis, Se han descrito efectos de desnutrición (DN sobre órganos linfáticos. Los mecanismos de defensa del huésped son alterados con DN proteico-calórico (DPC.SummaryThe Trichinellosis is an endemic zoonosis, which cosmopolitan guests are: rat, pig and other mammals including humans. Immunogens have beencharacterized, with the inmunodominant of 45kDa, effective against T.spiralis. Have described effects of malnutrition on lymphatic organs. The host's defense mechanisms are altered by caloric DN protein (DCP.Objective: To evaluate the indirect immunofluorescence technic in LongEvans rats and DN OUR infected immunized with T. spiralis and theimmunogenicity of 45 kDa.

  12. Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage.

    Science.gov (United States)

    Hutter-Paier, B; Reininger-Gutmann, B; Wronski, R; Doppler, E; Moessler, H

    2015-01-01

    Aging is associated with morphological and functional changes in the brain, resulting in the deterioration of cognitive performance. Growth factors like BDNF are suggested to be involved in the regulation of age-related processes in the brain. A novel dietary supplement produced from purified nerve cell proteins, N-PEP-12, has shown to share properties with naturally occurring peptide growth factors by stimulating neurite outgrowth and beneficial effects on neuronal survival and protection against metabolic stress in cell cultures. The current study investigates the effects of long-term intake on age-dependent memory decline by assessing cognitive performance and synaptic density. All the experiments were performed in aged Long Evans rats randomly assigned to saline or N-PEP-12 once daily by gavage over a period of three months. Behavioral tests were performed in the Morris Water Maze after one, two and three months of treatment. Histological examinations were performed in the hippocampal formation and in the entorhinal cortex by measuring the synaptic density. This study shows that the oral intake of N-PEP-12 has beneficial effects on the cognitive performance of aged animals and that these effects go along with an increase in the synaptic density. Thus, N-PEP-12 may help maintain memory and learning performance during the aging process.

  13. 从语言顺应论看伊文・金《骆驼祥子》的英译%On Evan King's English Version of Luotuo Xiangzi from the Perspective of Language Adaptation Theory

    Institute of Scientific and Technical Information of China (English)

    潘雪莱

    2012-01-01

      Verschueren's Language Adaptation Theory assumes that language used to be a continuous making of linguistic choices with different degrees of salience for the purpose of adaptation .This paper analyzes Evan King's English Version of Luotuo Xiangzi and points out that the choice of text adapts the need of American society of the time and the translation tactics depends on the translation purpose and the reading expectation .%  维索尔伦的语言顺应论指出语言的使用是在不同意识程度下为了顺应交际的需要而不断做出选择的过程。对伊文・金《骆驼祥子》的英译作出分析,指出其在文本的选择上顺应了当时美国社会的需要,而其翻译策略取决于翻译目的并且顺应了读者的阅读期待。

  14. A new species of Dermopristis Kearn, Whittington & Evans-Gowing, 2010 (Monogenea: Microbothriidae), with observations on associations between the gut diverticula and reproductive system and on the presence of denticles in the nasal fossae of the host Glaucostegus typus (Bennett) (Elasmobranchii: Rhinobatidae)

    OpenAIRE

    Whittington, ID; Kearn, GC

    2011-01-01

    Dermopristis cairae n. sp. (Microbothriidae) is described from the skin and possibly from the nasal fossae of the giant shovelnosed ray Glaucostegus typus (Bennett). The new species is distinguished from D. paradoxus Kearn, Whittington & Evans-Gowing, 2010 by its larger size, body shape, lack of transverse ridges on the ventral surface and absence of a seminal receptacle. Extensive short gut branches lie dorsal to the testes and adjacent to the coiled region of the vas deferens and the oo¨typ...

  15. Effects of GLP-1 treatment on protection of B cells in Otsuka Long-Evans Tokushima fatty rats%胰升糖素样多肽-1对OLETF大鼠胰腺的保护作用

    Institute of Scientific and Technical Information of China (English)

    王昱; 郭晓蕙

    2006-01-01

    目的:观察胰升糖素样多肽-1(glucagon like peptide-1, GLP-1)对OLETF(Otsuka Long-Evans Tokushima fatty)大鼠血糖和糖耐量的影响,及其对胰腺B细胞的保护作用.方法:将12周雄性OLETF大鼠分为GLP-1治疗和未治疗组,并以同种系非糖尿病LETO(Long-Evans Tokushima Otsuka)大鼠为正常对照.于12,14及20周时,对所有大鼠进行口服葡萄糖耐量试验(OGTT)试验,饲养至20周时处死.对胰腺病理切片分别进行HE染色、胰岛素染色、增殖细胞核抗原染色(proliferation cell nuclear antigen, PCNA)及凋亡细胞染色,测量胰岛B细胞的增殖率和凋亡率.用电镜观察胰岛内细胞超微结构.结果:(1)14及20周OLETF大鼠GLP-1治疗组血糖曲线下面积低于OLETF未治疗组,分别为(29.93±3.15 vs. 34.99±4.30, P<0.01)和(38.37±3.18 vs. 42.38±2.37,P<0.01).(2)14及20周OLETF大鼠 GLP-1治疗组胰岛素曲线下面积高于OLETF未治疗组,分别为(10.86±1.56 vs. 9.07±1.28,P<0.01)和(13.00±1.50 vs. 10.35±0.86,P<0.01).(3)20周龄GLP-1治疗组OLETF大鼠胰岛内胰岛素含量以及胰岛中B细胞数量增加,B细胞超微结构改善.胰岛B细胞的增殖率增加(48.9±39.6 vs. 39.6±9.3,P<0.05),凋亡率下降(24.8±4.2 vs. 30.8±5.8,P<0.01).结论:GLP-1能够通过促进胰岛B细胞增殖抑制其凋亡,增加胰岛B细胞数目,改善B细胞内分泌颗粒的形态,从而改善2型糖尿病大鼠的糖耐量.

  16. 求同存异和求异存同:同性婚姻的宪法之纬%Commentary on Evan Gerstmann's Same-sex Marriage and the Constitution

    Institute of Scientific and Technical Information of China (English)

    郭晓飞

    2005-01-01

    每个人都有和同性别的人结婚的权利,并且是受宪法保护的基本权利,即使是在美国,即使是对于一些支持同性婚姻的人,这样的观点也显得激进。不过《同性婚姻和宪法》这本书的作者伊凡·杰斯特曼(Evan Gerstmann)拒绝了寻求更审慎目标的进路.诉诸于最高大法挑战传统婚姻模式,可谓是“一竿子捅到底”了。所以在汉语语境中,这本书不可避免会显得惊世骇俗,甚至这篇评论也可能会有横空出世的感觉。笔者抱着“一事不知,儒人之耻”的态度来介绍这本书,以期待避免学术视野中的盲区和“少见多怪”.更重要的是,对此一议题的讨论牵涉到对法院在社会中角色的反思、民主和宪政的冲突,

  17. Herbal composition Gambigyeongsinhwan (4) from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats.

    Science.gov (United States)

    Roh, Jong Sung; Lee, Hyunghee; Woo, Sangee; Yoon, Miso; Kim, Jeongjun; Park, Sun Dong; Shin, Soon Shik; Yoon, Michung

    2015-08-02

    Adipocyte lipid accumulation due to impaired fatty acid oxidation causes adipocyte hypertrophy and adipose tissue increment, leading to obesity. The aim of this study was to determine the antiobesity effects of the herbal composition Gambigyeongsinhwan (4) (GGH(4)) composed of Curcuma longa L. (Zingiberaceae), Alnus japonica (Thunb.) Steud. (Betulaceae), and the fermented traditional Korean medicine Massa Medicata Fermentata. The effects of GGH(4) and the individual components on lipid accumulation in 3T3-L1 adipocytes and body weight gain in Otsuka Long-Evans Tokushima Fatty (OLETF) rats were examined using Oil red O staining, hematoxylin and eosin staining, quantitative real-time PCR, and peroxisome proliferator-activated receptor α (PPARα) transactivation assay. GGH(4), individual components, and an active principle of Curcuma longa curcumin inhibited lipid accumulation and mRNA levels of adipocyte-specific genes (PPARγ, aP2, and C/EBPα) in 3T3-L1 adipocytes compared with control cells. Treatment with GGH(4), the individual components or curcmumin increased mRNA levels of mitochondrial (CPT-1, MCAD, and VLCAD) and peroxisomal (ACOX and thiolase) PPARα target genes. GGH(4) and the individual components also increased PPARα reporter gene expression compared with control cells. These effects were most prominent in GGH(4)-treated cells. However, the PPARα antagonist GW6471 reversed the inhibitory effects of GGH(4) on adipogenesis. An in vivo study showed that GGH(4) decreased body weight gain, adipose tissue mass, and visceral adipocyte size with increasing mRNA levels of adipose tissue PPARα target genes in OLETF rats. These results demonstrate that GGH(4) has an antiobesity effects through the inhibition of adipocyte lipid accumulation, and this process may be mediated in part through adipose PPARα activation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. 78 FR 44577 - Senior Executive Service Performance Review Board

    Science.gov (United States)

    2013-07-24

    ..., Scott K. Farley, Evan T. Farmer, Robert A. Fenton, Robert J. Fisher, Michael J. Fitzgerald, Karen Flinn... Palmer, David J. Parent, Wayne Paschall, Robert Patrick, Connie L Patterson, Leonard Peavy, Sandy H. Penn.... Beers, Rand Benda, Francis Bersin, Alan Bester, Margot Bibo, David R. Borkowski, Mark S. Borras, Rafael...

  19. Síndrome de Evans en lactantes

    Directory of Open Access Journals (Sweden)

    Olivia Alejandra Flores-Montes

    2017-03-01

    Conclusiones: En el abordaje del paciente pediátrico con trombocitopenia se deben buscar alteraciones de otra línea celular. En los casos reportados se detectó la presencia de anemia hemolítica y monocitosis, por lo que se deben incluir estudios infecciosos e inmunológicos. El tratamiento de primera línea es con esteroides, y debe considerarse la administración de inmunoglobulina si existe trombocitopenia severa asociada, como se observó en estos casos.

  20. Craniofacial form is altered by chronic adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD in Han/Wistar and Long–Evans rats with different aryl hydrocarbon receptor (AhR structures

    Directory of Open Access Journals (Sweden)

    Sabrina B. Sholts

    2015-01-01

    Full Text Available Mammalian bone has shown a variety of responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD exposure in experimental and wildlife studies. Although many responses have been well characterized in the postcranial skeleton, dioxin-induced effects on the cranium are largely unknown. In this study, we investigated the effects of chronic adult exposure to TCDD on cranial size and shape in dioxin-resistant Han/Wistar (H/W and dioxin-sensitive Long–Evans (L–E rat strains. Three-dimensional landmark configurations for the face, vault, and base of the cranium were recorded and analyzed using geometric morphometrics (GM and dose–response modeling. The strongest effects were shown by L–E and H/W rats with daily exposures of 100 and 1000 ng TCDD/kg bw/day, respectively, resulting in significant reductions in centroid size (CS in all three cranial modules for both strains except for the vault in H/W rats. Consistent with previous evidence of intraspecific variation in TCDD resistance, the benchmark doses (CEDs for cranial size reduction in L–E rats were roughly 10-fold lower than those for H/W rats. For both strains, the face showed the greatest size reduction from the highest doses of TCDD (i.e., 3.6 and 6.3% decreases in H/W and L–E rats, respectively, most likely related to dose-dependent reductions in limb bone size and body weight gain. However, intrinsic morphological differences between strains were also observed: although the control groups of H/W and L–E rats had vaults and bases of comparable size, the face was 6.4% larger in L–E rats. Thus, although H/W rats possess an altered aryl hydrocarbon receptor (AhR that appears to mediate and provides some resistance to TCDD exposure, their smaller reductions in facial size may also relate to strain-specific patterns of cranial development and growth. Future research will be aimed at understanding how ontogenetic factors may modulate toxic effects of prenatal and lactational exposure on

  1. Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Mori Y

    2014-06-01

    Full Text Available Yutaka Mori,1,2 Shizuka Aritomi,3 Kazumi Niinuma,3 Tarou Nakamura,3 Kenichi Matsuura,1 Junichi Yokoyama,1 Kazunori Utsunomiya1 1Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Japan; 2Department of Clinical Research, National Hospital Organization, Utsunomiya National Hospital, Utsunomiya, Japan; 3Research Center, Ajinomoto Pharmaceuticals Co, Ltd, Kanagawa, Japan Abstract: Cilnidipine (Cil, which is an L-/N-type calcium channel blocker (CCB, has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS and the renin–angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml, which is an L-type CCB, with an angiotensin (Ang II receptor blocker on diabetic cardiorenal damage in spontaneously type 2 diabetic rats. Seventeen-week-old Otsuka Long-Evans Tokushima Fatty rats were randomly assigned to receive Cil, Aml, valsartan (Val, Cil + Val, Aml + Val, or a vehicle (eight rats per group for 22 weeks. Antihypertensive potencies were nearly equal among the CCB monotherapy groups and the combination therapy groups. The lowering of blood pressure by either treatment did not significantly affect the glycemic variables. However, exacerbations of renal and heart failure were significantly suppressed in rats administered Cil or Val, and additional suppression was observed in those administered Cil + Val. Although Val increased the renin–Ang system, Aml + Val treatment resulted in additional increases in these parameters, while Cil + Val did not show such effects. Furthermore, Cil increased the ratio of Ang-(1–7 to Ang-I, despite the fact that Val and Aml + Val decreased the Ang-(1–7 levels. These actions of Cil + Val might be due to their synergistic inhibitory effect on the activity of the SNS, and on aldosterone secretion through N-type calcium channel antagonism and Ang II

  2. Maya Children. Helpers at the Farm (Karen L. Kramer

    Directory of Open Access Journals (Sweden)

    Gema Campos Hernando

    2007-01-01

    Full Text Available Los habitantes de Xculoc, una aldea maya en la península de Yucatán, viven de sus cultivos de maíz y mantienen una agricultura de subsistencia sin haber entrado a formar parte del mercado laboral ni de la economía regional. La aldea, en la que viven 316 habitantes distribuidos en 55 casas familiares, está a cinco horas de camino de cualquier vía asfaltada, sin electricidad ni agua corriente. Los habitantes de Xculoc tienen de particular una tasa de natalidad muy alta y una mortalidad infantil muy baja, en parte por la ausencia de aguas contaminadas en los alrededores del poblado, llegando a conformarse el núcleo familiar por la madre, el padre y hasta ocho hijos. Esta estructura familiar no se podría mantener con el exclusivo trabajo de los padres , las necesidades de consumo son cubiertas por todos los miembros de la familia, dependiendo sus aportaciones no sólo del tamaño de la familia sino también de la estructura de la misma según edades.

  3. Health and Human Rights in Karen State, Eastern Myanmar.

    Science.gov (United States)

    Davis, William W; Mullany, Luke C; Shwe Oo, Eh Kalu; Richards, Adam K; Iacopino, Vincent; Beyrer, Chris

    2015-01-01

    Decades of conflict in eastern Myanmar have resulted in high prevalence of human rights violations and poor health outcomes. While recent ceasefire agreements have reduced conflict in this area, it is unknown whether this has resulted in concomitant reductions in human rights violations. We conducted a two-stage cluster survey of 686 households in eastern Myanmar to assess health status, access to healthcare, food security, exposure to human rights violations and identification of alleged perpetrators over the 12 months prior to January 2012, a period of near-absence of conflict in this region. Household hunger (FANTA-2 scale) was moderate/high in 91 (13.2%) households, while the proportion of households reporting food shortages in each month of 2011 ranged from 19.9% in December to 47.0% in September, with food insecurity peaking just prior to the harvest. Diarrhea prevalence in children was 14.2% and in everyone it was 5.8%. Forced labor was the most common human rights violation (185 households, 24.9%), and 210 households (30.6%) reported experiencing one or more human rights violations in 2011. Multiple logistic regression analysis identified associations between human rights violations and poor health outcomes. Human rights violations and their health consequences persist despite reduced intensity of conflict in eastern Myanmar. Ceasefire agreements should include language that protects human rights, and reconciliation efforts should address the health consequences of decades of human rights violations.

  4. Ettevõttel lasub ühiskondlik vastutus / Karen Schmidt

    Index Scriptorium Estoniae

    Schmidt, Karen

    2011-01-01

    Terve Eesti SA algatusel Eesti ettevõtete poolt moodustatud koalitsioonist "Ettevõtted HIV vastu", kuhu kuuluvad Hill & Knowlton, Nordecon, Swedbank, TNS Emor, Coca-Cola, Johnson & Johnson, Rimi Eesti Food, DHL Estonia, Boehringer Ingelheim, Radisson BLU Hotell Tallinn ja TBWA/Guvatrak. Koalitsiooni töös osales kolm aastat ka Statoil

  5. Karen Blixen's "The Poet" and Søren Kierkegaard's 'Gjentagelsen'

    DEFF Research Database (Denmark)

    Bunch, Mads

    2014-01-01

    attention to a reoccurring character in Kierkegaard’s production: the elderly bachelor esthete (Constantin Constantius), whom Blixen in “The Poet” exposes as a demonic, yet comical character. I will conclude by pointing out that repetition should be acknowledged as an integral part of Blixen’s poetics...

  6. Ettevõttel lasub ühiskondlik vastutus / Karen Schmidt

    Index Scriptorium Estoniae

    Schmidt, Karen

    2011-01-01

    Terve Eesti SA algatusel Eesti ettevõtete poolt moodustatud koalitsioonist "Ettevõtted HIV vastu", kuhu kuuluvad Hill & Knowlton, Nordecon, Swedbank, TNS Emor, Coca-Cola, Johnson & Johnson, Rimi Eesti Food, DHL Estonia, Boehringer Ingelheim, Radisson BLU Hotell Tallinn ja TBWA/Guvatrak. Koalitsiooni töös osales kolm aastat ka Statoil

  7. Köök - meelte ateljee / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2008-01-01

    2008. a. valminud õppeköögist "Köök" Tallinnas Pikk t. 42. Sisekujundus: Indrek Kasela, Sikke Sumari (omanikud). Paekivi- ja punasetest tellistest seintega ruumi kaunistab moodne kunst. Skulpturaalse veini- ja raamaturiiuli on kavandanud Edith Karlson ja Flo Kasearu, lühtri autor on Anna Roomet

  8. Jaani kiriku savipead ajavad juttu Nigulistes / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Niguliste muuseum-kontserdisaalis eksponeeritavatest Tartu Jaani kiriku 14. sajandi terrakotaskulptuuridest. Eksponeeritakse ka arhitektuurseid elemente - kapiteele, konsoole, päiskive. Jaani kiriku ajaloost

  9. Hoolega valitud värvilaik / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Korter Rannamõisas. Korteri on kujundanud omanik pereliikmetega, kellest üks on arhitekt Pelle-Sten Viiburg, kes kavandas ka köögilaua. Kolmetoaline korter muudeti kahetoaliseks. Põhiideeks oli tekitada monokroomne ruum, kus aktsendi looksid üksikud värvilised mööbliesemed

  10. Kiasma-mees Perttu Rastas jagas kogemusi / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Kiasma meediakonsultandi ja kuraatori Perttu Rastase ettekanne Tartus Lutsu teatrimajas muuseumi toimimisest kunstitegemise võimalikkuseni. Teksti illustreerimiseks näidati Roi Vaara, Erkki Kurenniemi, Eija Liisa Ahtila videosid. Juttu oli ka Teemu Mäki kassitapmist kujutavast videost

  11. Valge villa / Karen Jagodin ; kommenteerinud Krista Aren, Emil Urbel

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Villa (623 m² + kelder) Merirahu elamurajoonis Tallinnas. Arhitektid: Emil Urbel, Andrus Mark (AB Emil Urbel OÜ). Sisearhitektid: Krista Aren, Mati Veermets. Inseneriosad: AS Meistri Projekt. Haljastaja: Piret Kukk. Projekt: 2005-2008, valmis: 2009. Villa madalamat osa katab murtud pinnaga graniit, kõrgemat valge krohv

  12. Jaani kiriku savipead ajavad juttu Nigulistes / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Niguliste muuseum-kontserdisaalis eksponeeritavatest Tartu Jaani kiriku 14. sajandi terrakotaskulptuuridest. Eksponeeritakse ka arhitektuurseid elemente - kapiteele, konsoole, päiskive. Jaani kiriku ajaloost

  13. Hoolega valitud värvilaik / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Korter Rannamõisas. Korteri on kujundanud omanik pereliikmetega, kellest üks on arhitekt Pelle-Sten Viiburg, kes kavandas ka köögilaua. Kolmetoaline korter muudeti kahetoaliseks. Põhiideeks oli tekitada monokroomne ruum, kus aktsendi looksid üksikud värvilised mööbliesemed

  14. Köök - meelte ateljee / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2008-01-01

    2008. a. valminud õppeköögist "Köök" Tallinnas Pikk t. 42. Sisekujundus: Indrek Kasela, Sikke Sumari (omanikud). Paekivi- ja punasetest tellistest seintega ruumi kaunistab moodne kunst. Skulpturaalse veini- ja raamaturiiuli on kavandanud Edith Karlson ja Flo Kasearu, lühtri autor on Anna Roomet

  15. Valge villa / Karen Jagodin ; kommenteerinud Krista Aren, Emil Urbel

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Villa (623 m² + kelder) Merirahu elamurajoonis Tallinnas. Arhitektid: Emil Urbel, Andrus Mark (AB Emil Urbel OÜ). Sisearhitektid: Krista Aren, Mati Veermets. Inseneriosad: AS Meistri Projekt. Haljastaja: Piret Kukk. Projekt: 2005-2008, valmis: 2009. Villa madalamat osa katab murtud pinnaga graniit, kõrgemat valge krohv

  16. Kiasma-mees Perttu Rastas jagas kogemusi / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Kiasma meediakonsultandi ja kuraatori Perttu Rastase ettekanne Tartus Lutsu teatrimajas muuseumi toimimisest kunstitegemise võimalikkuseni. Teksti illustreerimiseks näidati Roi Vaara, Erkki Kurenniemi, Eija Liisa Ahtila videosid. Juttu oli ka Teemu Mäki kassitapmist kujutavast videost

  17. Mies van der Rohe preemia 2011 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2011-01-01

    20. juunil antakse Barcelonas inglise arhitektile Sir David Chipperfieldile Berliini Neues Museumi restaureerimise eest üle 2011. aasta Mies van der Rohe arhitektuuripreemia. Nimetatud võidutöö viis suuremat konkurenti, varem preemia pälvinud hooneid ja nende autoreid. Sir David Chipperfieldist, Berliini Neues Muuseumi restaureerimisest. Loetletud preemia nominendid Eestist

  18. CERT tribal internship program. Final intern report: Karen Sandoval, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The purpose of the project was to: create a working relationship between CERT and Colorado State University (CSU); involve and create relationships among individuals and departments at CSU; empower Native communities to run their own affairs; establish programs for the benefit of Tribes; and create Native American Program Development Office at CSU. The intern lists the following as the project results: revised a Native American Program Development document; confirmation from 45 departments across campus for Summit attendance [Tribal Human Resource Development Summit]; created initial invitee list from CSU departments and colleges; and informed CERT and CSU staff of results. Much of the response from the campus community has been positive and enthusiastic. They are ready to develop new Native American programs on campus, but need the awareness of what they can do to be respectful of Tribal needs.

  19. Health and Human Rights in Karen State, Eastern Myanmar.

    Directory of Open Access Journals (Sweden)

    William W Davis

    Full Text Available Decades of conflict in eastern Myanmar have resulted in high prevalence of human rights violations and poor health outcomes. While recent ceasefire agreements have reduced conflict in this area, it is unknown whether this has resulted in concomitant reductions in human rights violations.We conducted a two-stage cluster survey of 686 households in eastern Myanmar to assess health status, access to healthcare, food security, exposure to human rights violations and identification of alleged perpetrators over the 12 months prior to January 2012, a period of near-absence of conflict in this region. Household hunger (FANTA-2 scale was moderate/high in 91 (13.2% households, while the proportion of households reporting food shortages in each month of 2011 ranged from 19.9% in December to 47.0% in September, with food insecurity peaking just prior to the harvest. Diarrhea prevalence in children was 14.2% and in everyone it was 5.8%. Forced labor was the most common human rights violation (185 households, 24.9%, and 210 households (30.6% reported experiencing one or more human rights violations in 2011. Multiple logistic regression analysis identified associations between human rights violations and poor health outcomes.Human rights violations and their health consequences persist despite reduced intensity of conflict in eastern Myanmar. Ceasefire agreements should include language that protects human rights, and reconciliation efforts should address the health consequences of decades of human rights violations.

  20. Mies van der Rohe preemia 2011 / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2011-01-01

    20. juunil antakse Barcelonas inglise arhitektile Sir David Chipperfieldile Berliini Neues Museumi restaureerimise eest üle 2011. aasta Mies van der Rohe arhitektuuripreemia. Nimetatud võidutöö viis suuremat konkurenti, varem preemia pälvinud hooneid ja nende autoreid. Sir David Chipperfieldist, Berliini Neues Muuseumi restaureerimisest. Loetletud preemia nominendid Eestist

  1. Health and Human Rights in Karen State, Eastern Myanmar

    Science.gov (United States)

    Davis, William W.; Mullany, Luke C.; Shwe Oo, Eh Kalu; Richards, Adam K.; Iacopino, Vincent; Beyrer, Chris

    2015-01-01

    Background Decades of conflict in eastern Myanmar have resulted in high prevalence of human rights violations and poor health outcomes. While recent ceasefire agreements have reduced conflict in this area, it is unknown whether this has resulted in concomitant reductions in human rights violations. Methods and Findings We conducted a two-stage cluster survey of 686 households in eastern Myanmar to assess health status, access to healthcare, food security, exposure to human rights violations and identification of alleged perpetrators over the 12 months prior to January 2012, a period of near-absence of conflict in this region. Household hunger (FANTA-2 scale) was moderate/high in 91 (13.2%) households, while the proportion of households reporting food shortages in each month of 2011 ranged from 19.9% in December to 47.0% in September, with food insecurity peaking just prior to the harvest. Diarrhea prevalence in children was 14.2% and in everyone it was 5.8%. Forced labor was the most common human rights violation (185 households, 24.9%), and 210 households (30.6%) reported experiencing one or more human rights violations in 2011. Multiple logistic regression analysis identified associations between human rights violations and poor health outcomes. Conclusion Human rights violations and their health consequences persist despite reduced intensity of conflict in eastern Myanmar. Ceasefire agreements should include language that protects human rights, and reconciliation efforts should address the health consequences of decades of human rights violations. PMID:26308850

  2. ...Da ne sudimõ budete / Karen Drambjan

    Index Scriptorium Estoniae

    Drambjan, Karen

    2008-01-01

    Autor analüüsib, millised on võimaliku vene parteide kandidaadi Georgi Bõstrovi võimalused saada valituks Euroopa Parlamenti. Vt. ka Mihhail Petrov. Tjomna voda v oblatsehh, Vesti Dnja 2. juuni 2008 lk. 4

  3. Evans calcaneal lengthening osteotomy for treatment of symptomatic pes planovalgus in children%采用Evans跟骨延长术治疗儿童特发性痛性扁平足

    Institute of Scientific and Technical Information of China (English)

    闫桂森; 朱振华; 张建立; 杨征; 董轶非; 郭源

    2009-01-01

    目的 评价儿童痛性扁平足Evans跟骨延长术的矫正作用和效果.方法 患儿入选标准:负重及非负重情况下足内侧纵弓均降低或消失且合并疼痛症状者.本组自2006年1月至2008年7月共治疗18人23足,男11人,女7人,年龄11~14岁,平均12岁8个月,采用Evans跟骨截骨延长术进行治疗,平均随诊2年5个月,范围7个月至3年3个月,均为特发性病例,以前均进行过保守治疗且无效.术前、术后均拍照负重下前后位及侧位X线片,临床评价采用Dogan标准,X线评价包括7个参数,对术前、术后各项均值进行成组的t检验,P<0.05被认为差异有统计学意义.结果 临床评价优22足(96%),良1足(4%).术前与术后、术前与末次随访时各项X线参数的均值差异都存在统计学意义,且术后各项指标均数都在相应年龄段的正常值范围内.术后8周跟骨延长处开始愈合,术后1年塑形完成.跟骨平均延长8.0 mm(范围5~10 mm).未发生植骨块移动,无过度矫正,术后所有患儿均恢复正常跖行足负重行走.结论 对于有症状的儿童扁平足,保守治疗无效时,采用跟骨截骨延长术可以从临床和X线两个方面有效地矫正后足和前足畸形并缓解疼痛.%Objective To evaluate the results of modified Evans osteotomy technique for treatment of symptomatic pes planovalgus in children. Methods Criteria for inclusion in the study were the symptomatic patients whose loot's medial longitudinal arch was lowered or lost. Caleaneal lengthening osteotomy was performed using the modified Evans technique in 23 feet of 18 patients (11 males, 7 females) during Jan. of 2006 to Jul. of 2008, five patients had bilateral involvement. The mean followup was 2 years 5 months (range 7 months to 3 years and 3 months). All were idiopathic, and received long-term conservative therapy preoperatively. Anteroposterior and lateral radiographs of the feet with weight bearing were made at the time of presentation

  4. OLETF大鼠肺泡上皮细胞基板的超微结构改变与定量检测%Ultrastrucural characteristics and morphometry of the alveolar epithelial basal lamina in Otsuka Long-Evans Tokushima fatty rats

    Institute of Scientific and Technical Information of China (English)

    汤秀英; 王书合; 柴立军

    2009-01-01

    目的 观察自发性2型糖尿病OLETF(Otsuka Long-Evans Tokushima Fatty)大鼠肺泡上皮细胞基板的超微结构改变.方法 用透射电镜观察、图像分析仪及形态计量学方法计算OLETF及对照的LETO(Long-Evans Tokushima Otsuka)大鼠肺泡上皮细胞基板的超微结构及厚度.结果 与LETO组大鼠相比,OLETF组大鼠肺泡毛细血管内皮细胞基板与Ⅰ型肺泡上皮细胞基板融合部及Ⅱ型肺泡上皮细胞基板均增厚(分别为110.6±14.14 vs.57.3±11.08和116.4±10.22 vs.71.89±7.68,P<0.01).结论 OLETF大鼠肺泡上皮细胞基板增厚,提示可能与糖尿病高血糖环境引起毛细血管基板成分发生改变有关.

  5. A new species of Dermopristis Kearn, Whittington & Evans-Gowing, 2010 (Monogenea: Microbothriidae), with observations on associations between the gut diverticula and reproductive system and on the presence of denticles in the nasal fossae of the host Glaucostegus typus (Bennett) (Elasmobranchii: Rhinobatidae).

    Science.gov (United States)

    Whittington, Ian D; Kearn, Graham C

    2011-09-01

    Dermopristis cairae n. sp. (Monogenea: Microbothriidae) is described from the skin and possibly from the nasal fossae of the giant shovel-nosed ray Glaucostegus typus (Bennett). The new species is distinguished from D. paradoxus Kearn, Whittington & Evans-Gowing, 2010 by its larger size, body shape, lack of transverse ridges on the ventral surface and absence of a seminal receptacle. Extensive short gut branches lie dorsal to the testes and adjacent to the coiled region of the vas deferens and the oötype, possibly reflecting high metabolic demand in these areas. Denticles are present in the lining of the nasal fossae of G. typus, providing a firm substrate for the cement-based attachment of a microbothriid. However, confirmation that D. cairae inhabits the nasal fossae of G. typus is required.

  6. Effects of Rosiglitazone on Transforming Growth Factor-β1 and its Signaling Pathway Genes Expressions in Pulmonary Tissue of Otsuka Long-Evans Tokushima Fattv Rats%罗格列酮对OLETF大鼠肺组织转化生长因子β1及其信号转导分子的影响

    Institute of Scientific and Technical Information of China (English)

    刘佳; 赵伟; 宋旭臣; 郝久营; 张雅静; 张宏

    2012-01-01

    目的 探讨罗格列酮对自发性糖尿病OLETF( Otsuka Long-Evans Tokushima Fatty)大鼠肺组织纤维化的影响及其机制.方法 30周龄雄性OLETF大鼠16只,随机分为糖尿病组(DM组)和罗格列酮组(RGT组,予罗格列酮3 mg· kg-1·d-1灌胃12周),对照组为LETO (Long Evans Tokushima Otsuka)大鼠8只.HE、Masson染色观察各组大鼠肺组织结构及其胶原沉积变化,免疫印迹( Western blotting)方法检测肺组织Smad3 、Smad7和Ⅲ型胶原表达,ELISA检测肺组织转化生长因子β1(transforming growth factor-β1,TGF-β1)的表达.结果 与对照组大鼠相比,DM组大鼠肺组织TGF-β1、Smad3和Ⅲ型胶原表达增加,Smad7表达减少,差异均有统计学意义(P<0.05),肺组织胶原沉积增加,呈纤维化趋势;罗格列酮治疗可使RGT组大鼠上述指标逆转.结论 罗格列酮对OLETF大鼠肺组织有抗纤维化作用,可能通过下调TGF-β1/Smad信号转导通路发挥作用.%Objective To explore effects and its mechanism of Rosiglitazone treatment on transforming growth factor-β1/ SmadCTGF-β1Smad) signaling pathways in Otsuka Long-Evans Tokushima Fatty(OLETF) rats. Methods Sixteen OLETF rats were divided into two groups: DM group and rosiglitazone-treated group (RGT group) , and 8 of Long Evans Tokushima Otsuka (LETO) rats as control (N group). RGT group rats were treated with rosiglitazone (3 mg/kg/day, in drinking water) for 12 weeks, starting at the age of 30 weeks. The structural and collagen deposition changes of pulmonary tissue in three groups rats were observed by HE and Masson staining; the expression of Smad7 and collagen type III in lung tissues were examined by western blotting; the expression of TGF-β1 of lung tissues were examined by ELISA. Results The expression of TGF-pi, Smad3 and collagen type III increased in pulmonary tissues of OLETF rats, which higher than those of LETO rats (P<0.05). The expression of Smad7 decreased in OLETF group(P<0.05). Pulmonary interstitial

  7. Effects of rosiglitazone treatment on TGF-β1/Smad signaling pathways in Otsuka Long-Evans Tokushima Fatty rat lungs%罗格列酮对OLETF大鼠肺组织TGF-β1/Smad信号转导途径的影响

    Institute of Scientific and Technical Information of China (English)

    赵伟; 姜丽娟; 朱梦瑜; 刘佳; 张雅静; 陈晓琴; 张宏

    2011-01-01

    目的 探讨罗格列酮对自发性2型糖尿病Otsuka Long-Evans Tokushima Fatty(OLETF)大鼠肺组织转化生长因子(TGF)-β1 /Smad信号转导途径的影响.方法 OLETF大鼠16只,分为未治疗的OLETF组和接受罗格列酮治疗组(OLETF/L组)各8只,设Long Evans Tokushima Otsuka(LETO)大鼠8只为对照组.免疫组织化学分析各组大鼠肺组织TGF-β1、Smad2、Smad3、Smad7、纤维连接蛋白(FN)和Ⅲ型胶原表达.结果与LETO组大鼠相比,OLETF组大鼠肺组织TGF-β1、Smad2、Smad3、FN和Ⅲ型胶原表达均显著增加 (P<0.01),Smad7表达显著减少(P<0.01);OLETF/L组比OLETF组大鼠肺组织TGF-β1、Smad2、Smad3、FN和Ⅲ型胶原表达均显著减少(P<0.01),Smad7表达显著增加(P<0.01).结论罗格列酮可能通过调控TGF-β1/Smad信号转导途径抗糖尿病肺纤维化.%Objective To approach the effects of rosiglitazone treatment on transforming growth factor-β1/Smad (TGF-β1/Smad) signaling pathways in Otsuka Long-Evans Tokushima Fatty(OLETF) rats.Methods Experimental rats were divided into three groups: OLETF group, rosiglitazone-treated group( OLETF/L group) and Long Evans Tokushima Otsuka rats (LETO group) as control, 8 rats in each group.The expression of TGF-β1, Smad2, Smad3, Smad7,fibronectin(FN), and collagen type Ⅲ in rat lungs were examined by immunohistochemistry.Results The expressions of TGF-β1, Smad2, Smad3, FN and collagen type Ⅲ increased in OLETF rat lungs than those of LETO rats(P < 0.O1 ),while the expression of Smad7 decreased in OLETF group( P < 0.01 ).The expressions of TGF-β1, Smad2, Smad3, FN and collagen type Ⅲ decreased in OLETF/L group than those of the OLETF group ( P < 0.01 ), and the expression of Smad7 increased in OLETF/L group ( P < O.01 ).Conclusion Rosiglitazone may improve diabetic pulmonary fibrosis probably by regulating TGF-β1/ Smad signaling pathways.

  8. 自发性肝癌的LEC大鼠的GST-P异常表达和p53基因突变%p53 gene mutations and unusual expression of GST-P in spontaneous hepatocellular carcinoma of Long Evans Cinnamon rats

    Institute of Scientific and Technical Information of China (English)

    李兴华; 徐云虹; 许爱芳; 龚燕芳; 屠振兴; 李兆申

    2005-01-01

    原发性肝癌的发病原因及机制尚未完全清楚,可能与多种因素的综合作用有关,一般采用肝癌的手术标本或化学致癌的动物进行研究,但标本成分复杂,同质性差,影响因素多,从遗传学角度看,人体基因的高度杂合性,个体暴露于致癌物质的种类和量也不同,结果缺乏客观的评价。本实验采用自发性发生癌的实验动物LEC(Long Evans Cinnamon)鼠。

  9. Effects of glucagon like peptide-1 treatment on the alveolar capillary basal lamina in Otsuka Long-Evans Tokushima Fatty rats%胰高血糖素样多肽-1对OLETF大鼠肺泡毛细血管基板的影响

    Institute of Scientific and Technical Information of China (English)

    汤秀英; 王昱; 郭晓蕙; 王书合; 柴立军; 张烨

    2008-01-01

    目的:电镜观察并定量分析胰高血糖素样多肽-1(glucagon like peptide-1, GLP-1)对自发性2型糖尿病OLETF(Otsuka Long-Evans Tokushima Fatty)大鼠肺泡毛细血管基板的影响.方法:将OLETF大鼠分为未治疗的OLETF组及GLP-1治疗组(OLETF/G组),对照为LETO(Long-Evans Tokushima Otsuka)组大鼠.用透射电镜观察及形态计量学方法测量肺泡毛细血管基板的超微结构及厚度.结果:与LETO组大鼠相比,OLETF大鼠肺泡毛细血管内皮细胞基板与Ⅰ型肺泡上皮细胞基板融合部(F-BL)及肺泡毛细血管内皮细胞基板(Cap-BL)均增厚,分别为 (110.60±14.14) nm vs (57.30±11.08) nm和 (118.40±19.12) nm vs (66.80±8.63) nm (P<0.01).OLETF/G组大鼠肺F-BL及Cap-BL均比OLETF组大鼠明显变薄,分别为 (79.70±5.44) nm vs (110.60±14.14) nm和 (69.80±3.32) nm vs (118.40±19.12) nm (P<0.01).结论:OLETF大鼠肺泡毛细血管基板发生明显的超微结构变化;GLP-1治疗能减轻OLETF大鼠肺泡毛细血管基板损伤.

  10. Successors to Cause of Sino-US Friendship

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    <正>The 92-year-old Dr. Charles M. Grossman, president of Evans F. Carlson’s Friends of the People’s Republic of China, arrived at the Beijing International Airport with his son-in-law Mark Johnson on August 31, 2005. The 85-year-old Jeanne, daughter-in-law of Evans F. Carlson, and Karen Loving, granddaughter of Carlson arrived in Beijing 15 minutes later on the same day. It was quite meaningful that they met in Beijing as they had never met in the United States. They had come to China on the occasion of the 60th anniversary of

  11. Dualistlikud juhid : edukas toimetulek paradoksidega / Paul A. L Evans

    Index Scriptorium Estoniae

    Evans, Paul A. L

    2001-01-01

    INSEAD'i juhtimisprofessor väidab, et juhtidele esitatud väljakutse seisneb vastandite vahel manööverdamises. Juhtimise 11 paradoksi. Artikkel tõlgitud raamatust "Management 21C: Someday we'll all manage this way", 2000

  12. Potential antifungal activity of Cladonia aff. rappii A. Evans

    Directory of Open Access Journals (Sweden)

    Claudia M. Plaza

    2017-10-01

    Full Text Available Context: Lichen is a self-supporting symbiotic organism composed of a fungus and an algal partner. They have manifold biological activities like antiviral, antibiotic, antioxidant, antitumor, allergenic and inhibition of plant growth. Species of Cladonia, have been studied by its antifungal activity. Aims: To evaluate the antifungal activity determination of Cladonia aff. rappii against five yeasts, four of genus Candida and one Cryptococcus, using water, ethanol and dichloromethane extracts. Methods: The evaluation of the antifungal activity was developed by three diffusion methods such as spot-on-a-lawn, disc diffusion and well diffusion. Additionally, the values of minimal inhibitory concentration (MIC and the minimum fungicidal concentration (MFC were determined. Results: Based on the experimental results obtained, the best antifungal activity was using ethanol extract at 20 mg/mL against Candida albicans, applying the three diffusion methods above mentioned. With ethanol extract, the lower MIC was against Candida glabrata and the lower MFC were with Candida glabrata, C. krusei, C. parapsilosis and C. tropicalis. The dichloromethane extract presented the lowest MIC and MFC against C. neoformans. Not activity was observed with aqueous extract. Conclusions: The present study revealed antifungal and fungicidal activity in the extract of lichen Cladonia aff. rappii.

  13. OrthoImagery Submission for Evans County, GA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — NAIP imagery is available for distribution within 60 days of the end of a flying season and is intended to provide current information of agricultural conditions in...

  14. Effects of Fipronil on the EEG of Long Evans Rats

    Science.gov (United States)

    We have reported that the non-stimulus driven EEG is differentially altered by deltamethrin or permethrin (Lyke and Herr, Toxicologist, 114(S-1):265, 2010). In the current study, we examined the ability to detect changes in EEG activity produced by fipronil, a phenylpyrazole pest...

  15. Effects of Fipronil on the EEG of Long Evans Rats

    Science.gov (United States)

    We have reported that the non-stimulus driven EEG is differentially altered by deltamethrin or permethrin (Lyke and Herr, Toxicologist, 114(S-1):265, 2010). In the current study, we examined the ability to detect changes in EEG activity produced by fipronil, a phenylpyrazole pest...

  16. Meie igapäevane paanika / Ott Karulin

    Index Scriptorium Estoniae

    Karulin, Ott, 1980-

    2007-01-01

    Kahest Vanemuise teatri lavastusest Tartus - Saksa Kultuuri Instituudis etendunud Ingvar Ambjornseni-Axel Hellsteniuse "Elling" Ain Mäeotsa lavastuses ja Laura Cunninghami "Beautiful Bodies" Vanemuises, lavastaja Jüri Lumiste

  17. Dualistlikud juhid : edukas toimetulek paradoksidega / Paul A. L Evans

    Index Scriptorium Estoniae

    Evans, Paul A. L

    2001-01-01

    INSEAD'i juhtimisprofessor väidab, et juhtidele esitatud väljakutse seisneb vastandite vahel manööverdamises. Juhtimise 11 paradoksi. Artikkel tõlgitud raamatust "Management 21C: Someday we'll all manage this way", 2000

  18. DCS Terrain for Evans County GA MapMod08

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix M: Data Capture Standards, describes the digital topographic data that was used to create...

  19. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, EVANS COUNTY, GEORGIA, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk Information And supporting data used to develop the risk data. The primary risk;...

  20. SINK OR SWIM? DEBT REVIEW'S AMBIVALENT "LIFELINE" ---- A SECOND SEQUEL TO "… A TALE OF TWO JUDGMENTS" NEDBANK V ANDREWS (240/2011 2011 ZAECPEHC 29 (10 May 2011; FIRSTRAND BANK LTD V EVANS 2011 4 SA 597 (KZD AND FIRSTRAND BANK LTD V JANSE VAN RENSBURG 2012 2 All SA 186 (ECP

    Directory of Open Access Journals (Sweden)

    L Steyn

    2012-11-01

    Full Text Available The interface between the National Credit Act 34 of 2005 and the Insolvency Act 24 of 1936 has been the object of our courts' attention in a number of recent cases including Ex parte Ford and Two Similar Cases 2009 3 SA 376 (WCC, Investec Bank Ltd v Mutemeri 2010 1 SA 265 (GSJ, Naidoo v ABSA Bank Ltd 2010 4 SA 597 (SCA and, more recently, Nedbank v Andrews (240/2011 2011 ZAECPEHC 29 (10 May 2011, FirstRand Bank Ltd v Evans 2011 4 597 (KZD and FirstRand Bank Ltd v Janse van Rensburg 2012 2 All SA 186 (ECP. The question raised in all of the three most recent cases was whether or not a debtor's application for debt review in terms of the National Credit Act constitutes an "act of insolvency" in terms of section 8 of the Insolvency Act, upon which a creditor may rely in an application for the compulsory sequestration of the debtor's estate. If it does, it would mean that by resorting to the debt relief measures provided by the National Credit Act a debtor commits the very act on which a creditor may base an application for a sequestration order which, if granted, will render the debtor's estate insolvent and bring about the liquidation of his assets. From the debtor's perspective, this is probably precisely the situation that he seeks to avert by applying for debt review. Further, sequestration would frustrate the stated purpose of the National Credit Act, which is that debtors should take responsibility for their debts by satisfying them in full. Concurrent creditors might also ultimately receive a dividend which falls far short of what is due to them. The question of whether a debtor's resorting to debt review may or should be the very act that triggers his estate's sequestration and its attendant consequences is an important issue, the treatment of which impacts significantly on the efficacy of the South African consumer debt relief system. This article analyses the most recent judgments and considers whether or not statutory regulation of the

  1. Effects of rosiglitazone treatment on TGF-β1/JNK signaling pathways in otsuka long-evans tokushima fatty ratspulmonary%罗格列酮对OLETF大鼠肺组织TGF-β1/JNK信号转导途径的影响

    Institute of Scientific and Technical Information of China (English)

    赵伟; 陈晓琴; 朱梦瑜; 张宏

    2011-01-01

    Objective To approach effects of rosiglitazone treatment on transforming growth factor-β1/c-Jun NH2-terminal kinases(TGF-β1/JNK) signaling pathways in otsuka long-evans tokushima fatty(OLETF) rats. Methods Experimental rats were divided into three groups: OLETF group, rosiglitazone-treated group(OLETF/L group), and long evans tokushima otsuka(LETO group) as control. The expression of TGF-β1, p-JNK, collagen type Ⅰ in pulmonary of rats were examined by immunohistochemistry. Results The expression of TGF-β1, p-JNK and mean optical density, the ratio of positive area and total area of, collagen type Ⅰ were increased in pulmonary of OLETF rats than those of LETO rats(7.4438±0.6397 vs 1.1844±0.2066,5.7025±0.5530 vs 1.5875±0.1727 and 0.1195±0.0183 vs 0.0154±0.0016,0.0322±0.0058 vs 0.0033±0.0010;0.2628±0.0279 vs 0.0831±0.0096,0.0909±0.0138 vs 0.0385±0.0082, P<0.01). The expression of TGF-β1,p-JNK and mean optical density, the ratio of positive area and total area of, collagen type Ⅰ were decreased in OLETF/L group as compared with OLETF group(1.8398±0.3591 vs 7.4438±0.6397,1.7500±0.1690 vs 5.7025±0.5530 and 0.0223±0.0053 vs 0.1195±0.0183,0.0052±0.0019 vs 0.0322±0.0058;0.1152±0.0313 vs 0.2628±0.0279,0.0535±0.0119 vs 0.0909±0.0138, P<0.01). Conclusions Rosiglitazone may improve diabetic pulmonary fibrosis probably by regulating TGF-β1/JNK signaling pathways.%目的 探讨罗格列酮对自发性2型糖尿病OLETF 大鼠肺组织转化生长因子-β1(TGF-β1)/c-Jun氨基末端激酶(JNK)信号转导途径的影响.方法 将16只30周龄成模OLETF大鼠分为OLETF组和罗格列酮治疗组(OLETF/L组),设LETO大鼠8只为对照组.免疫组织化学分析肺组织TGF-β1、磷酸化(p)-JNK、Ⅰ型胶原表达.结果 与LETO组大鼠相比,OLETF组大鼠肺组织TGF-β1、p-JNK表达(7.4438±0.6397 vs 1.1844±0.2066、5.7025±0.5530 vs 1.5875±0.1727)及Ⅰ型胶原的阳性面积比、平均光密度(0.1705±0.0110 vs 0.0550±0.0048

  2. Expression of aquaporin 7 in perirenal adipose tissue of Otsuka Long-Evans Tokushima Fatty diabetic rats%自发2型糖尿病模型OLETF大鼠肾周脂肪组织水通道蛋白7的表达

    Institute of Scientific and Technical Information of China (English)

    段玉敏; 袁振芳; 姚军; 张婷婷; 陈程; 郭晓蕙

    2011-01-01

    目的:观察自发2型糖尿病动物模型OLETF(Otsuka Long-Evans Tokushima Fatty)大鼠不同糖尿病病程阶段肾周脂肪组织水通道蛋白7 mRNA和蛋白表达的变化,探讨其在肥胖和糖尿病发生中的作用.方法:以OLETF大鼠30只为实验组,同种系非糖尿病LETO(Long-Evans Tokushima Otsuka)大鼠18只为正常对照.8周(基线)时两组大鼠各处死6只.随后OLETF大鼠分为末治疗组(OLETF组)12只及盐酸二甲双胍治疗组(OLETF/M组)12只.观察各组大鼠8、18、28周时的体重、血清甘油三酯、胆固醇、丙三醇、葡萄糖耐量试验的血糖与胰岛素水平以及肾周脂肪组织水通道蛋白7(aquaporin7,AQP7)mRNA和AQP7蛋白含量的变化.用Real-time PCR测定AQP7mRNA水平,Western blotting测定AQP7蛋白含量.结果:(1)OLETF组18周均发展为糖尿病[60分钟血糖(25.67±6.78)mmol/L,120分钟血糖(16.19±2.98)mmoL/L].OLETF组大鼠随周龄增加,其体重、血糖、胰岛素、血清甘油三酯均明显增加.血清丙三醇水平先增高后下降,8、18和28周的水平分别为(52.61±11.80)、(156.03±39.56)和(130.84±25.46)μmol/L.(2)OLETF/M组18周时达糖尿病标准[60分钟血糖(18.64±6.67)mmol/L,120分钟血糖(14.13±5.21)mmoL/L],但血糖水平低于OLETF组;28周时血糖下降均恢复为糖耐量异常[60分钟血糖(11.72 ±3.06)mmol/L,120分钟血糖(12.42±2.30)mmol/L].OLETF/M组的甘油三酯、胆固醇和丙三醇浓度较OLETF组降低.OLETF/M组与OLEFT组比较具体值为:甘油三酯18周(0.88±0.14)vs.(1.09 ±0.44)mmol/L,28周(1.06±0.51)vs.(2.20±1.51)mmol/L;胆同醇18周(2.18±0.14)vs.(2.30±0.21)mmol/L,28周(1.90±0.19)vs.(2.36±0.35)mmol/L,P<0.05;丙三醇18周(77.28±9.06)vs.(156.03±39.56)μmol/L,P<0.05,28周(58.44±14.03)vs.(130.84±25.46)μmol/L,P<0.01.(3)增加肾周脂肪组织AQP7 mRNA及蛋白表达:随周龄及肥胖增加,18及28周OLETF组AQP7 mRNA表达较同组8周龄大鼠分别上调了67.5%和41.7%,AQP7蛋白表达较同组8

  3. Intra-acting with Karen Barad in Psychology – and across Disciplines

    DEFF Research Database (Denmark)

    Søndergaard, Dorte Marie

    With my work situated in social psychology and employing empirical analytics brought together across the social sciences and humanities, I will contribute to this line of ideas of ways of working analytically with agential realism by offering three brief examples of empirical analyses from my...... realist conceptualizations help complicate common-sense understandings of the effects of aggression as played out in digital dimensions of everyday life among children and young people. In relation to this example, I discuss how to communicate analytical points without losing complexity as the basic...

  4. Sisearhitekt Pille Lausmäe - Tallinna töö- ja toidukultuuri looja / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Omanimelise arhitektuuribüroo omanik sisearhitekt Pille Lausmäe oma elust ja tööst, isast sisearhitekt Väino Tammest. Eesti Kunstiakadeemias õpib sisearhitektuuri ka Pille poeg Ville Lausmäe ja töötab ema büroos. Pillet iseloomustavad Priit Põldme, Riina Sildots, Rein Tallermo, Mari Kaljuste

  5. Uus kunstikool näitab oma nägu ja hambaid / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Positivistliku Kunsttööstuskooli kampaaniapäevad algasid Performance Week'iga Ku galeriis. Avamisel esines Mari Sobolev performance'iga "Lost in the system". Kampaaniapäevad kulmineeruvad Paide tegevuskunstifestivaliga "Aeg. Ruum. Liikumine: unplugged". Festivali kuraator on Mari Sobolev

  6. Moodne kortermaja miljööväärtuslikul alal / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2005-01-01

    Korterelamu Tallinnas Kalamajas Vabriku t. 33. Arhitektid: Raivo Kotov, Tõnis Kimmel, AB KOKO. Sisearhitektid: Raili Paling, Liis Lindvere. Ehitaja: Celander Ehitus OÜ. Valmis 2005. Ill.: 3 värv. välis- ja 3 sisevaadet

  7. Puhkus moodsas kalurikülas / Karen Jagodin ; kommenteerinud Indrek Mikk, Raivo Kotov

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    GoSpa residentsid Kuressaares. Arhitektid: Indrek Mikk, Raivo Kotov (KOKO Arhitektid). Sisearhitekt: Kätlin Ölluk. Projekt: 2007, valmis: 2009. Suvitajatele mõeldud viiest kahekorruselisest hoonest koosnev ansambel on liigendatud mahtude ja lehisepuidust-betoonist fassaadidega. Terrassid ja rõdud avanevad peamiselt suunaga merele. Kortereid saab endale osta või üürida

  8. Arhitekti ilumeel väljendub just nüanssides / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Eesti Arhitektide Liidu korraldatud väikevormide arhitektuurivõistlusest "Väike 2002-2006" ja näitusest Eesti Arhitektuurimuuseumis. Avatud 9.05.-3.06.2007. Konkursi esimest-teist kohta jagasid Tiit Kaljundi ja Ivo-Martin Veelma loodud Saka trepistik ning Ülar Margi ja Kaja Pae kujundatud Eesti Panga galerii

  9. Raikküla mõisa ait-kuivatist ja selle taastamisest / Karen Klandorf

    Index Scriptorium Estoniae

    Klandorf, Karen

    2014-01-01

    Täpne valmimisaeg ei ole teada, kuid 1864. aastal on mainitud seda kui vana hoonet. 1909. aastal ehitati juurde kuivati. Mõisa ait-kuivati on traditsiooniline ehitis, mille muudavad erandlikuks pikkkaaristu ja hoone katusel ilutsev kellatorn. Kuivati esindab üht levinumat kuivatitüüpi. Restaureerimistööd kestsid 2008-2013.

  10. Puhkus moodsas kalurikülas / Karen Jagodin ; kommenteerinud Indrek Mikk, Raivo Kotov

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    GoSpa residentsid Kuressaares. Arhitektid: Indrek Mikk, Raivo Kotov (KOKO Arhitektid). Sisearhitekt: Kätlin Ölluk. Projekt: 2007, valmis: 2009. Suvitajatele mõeldud viiest kahekorruselisest hoonest koosnev ansambel on liigendatud mahtude ja lehisepuidust-betoonist fassaadidega. Terrassid ja rõdud avanevad peamiselt suunaga merele. Kortereid saab endale osta või üürida

  11. Sisearhitekt Pille Lausmäe - Tallinna töö- ja toidukultuuri looja / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Omanimelise arhitektuuribüroo omanik sisearhitekt Pille Lausmäe oma elust ja tööst, isast sisearhitekt Väino Tammest. Eesti Kunstiakadeemias õpib sisearhitektuuri ka Pille poeg Ville Lausmäe ja töötab ema büroos. Pillet iseloomustavad Priit Põldme, Riina Sildots, Rein Tallermo, Mari Kaljuste

  12. Arhitekti ilumeel väljendub just nüanssides / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2007-01-01

    Eesti Arhitektide Liidu korraldatud väikevormide arhitektuurivõistlusest "Väike 2002-2006" ja näitusest Eesti Arhitektuurimuuseumis. Avatud 9.05.-3.06.2007. Konkursi esimest-teist kohta jagasid Tiit Kaljundi ja Ivo-Martin Veelma loodud Saka trepistik ning Ülar Margi ja Kaja Pae kujundatud Eesti Panga galerii

  13. Uus kunstikool näitab oma nägu ja hambaid / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Positivistliku Kunsttööstuskooli kampaaniapäevad algasid Performance Week'iga Ku galeriis. Avamisel esines Mari Sobolev performance'iga "Lost in the system". Kampaaniapäevad kulmineeruvad Paide tegevuskunstifestivaliga "Aeg. Ruum. Liikumine: unplugged". Festivali kuraator on Mari Sobolev

  14. Moodne kortermaja miljööväärtuslikul alal / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2005-01-01

    Korterelamu Tallinnas Kalamajas Vabriku t. 33. Arhitektid: Raivo Kotov, Tõnis Kimmel, AB KOKO. Sisearhitektid: Raili Paling, Liis Lindvere. Ehitaja: Celander Ehitus OÜ. Valmis 2005. Ill.: 3 värv. välis- ja 3 sisevaadet

  15. Walking and Mapping: Artists as Cartographers. By Karen O’Rourke. Cambridge, MA. MIT Press, 2013.

    Directory of Open Access Journals (Sweden)

    Joel Weishaus

    2014-06-01

    Full Text Available While there is a long well-documented tradition of poets walking and writing about the landscape, for at least the past fifty years visual artists have been laying out walks as various kinds of artwork. More recently, with the technology of mapping morphing into electronic devices, artists have begun using these tools to develop entirely new genres.

  16. Freud, females, childbirth, and dissidence: Margarete Hilferding, Karen Horney, and Otto Rank.

    Science.gov (United States)

    Balsam, Rosemary

    2013-10-01

    These three early psychoanalysts, who differed in important ways from Freud, each tried to shift his fundamental beliefs about women's bodies in basic developmental theory. This paper illustrates this point by elaborating their materials concerning the centrality of childbirth. One thematic aspect of Freud's disruptive fights with colleagues lay in his loyalty to phallocratic certainties. These problems still affect us, a century later, even in today's clinically pluralistic climate.

  17. Tarneahela tulude jagamine ja tarneahela juhtimise mõju firmale / Joel D Wisner, Karen Spens

    Index Scriptorium Estoniae

    Wisner, Joel D

    2007-01-01

    Ülevaade 2005. aastal Nevada ülikooli ja Helsingis asuva majanduskooli HANKEN poolt läbi viidud uuringust, mille eesmärgiks oli välja selgitada ja hinnata tarneahela juhtimistegevust Soome ja USA firmades. Lisa: Uuringus osalenud firmade kirjeldus

  18. Autopsia : [arvustatakse eelmises Marduses ilmunud originaaljutte ja tõlkeid] / Karen Orlau

    Index Scriptorium Estoniae

    Orlau, Karen, pseud., 1975-

    2000-01-01

    Arvustatavad jutud: Smith, Clark Ashton. Öised koletised; Kalevipoeg, pseud. Purpurvalgus; Brown, Molly. Valel ajal; Belials, Veiko. Kunagi. Kuskil. Eikuskil; Lindsay, David. Swaylone'i saar; Hargla, Indrek. Obernoni apokrüüf

  19. Kino Kosmos Imax = Kosmos Imax cinema / Pille Lausmäe ; kommenteerinud Karen Jagodin

    Index Scriptorium Estoniae

    Lausmäe, Pille, 1958-

    2015-01-01

    Kino Kosmos Imax Tallinnas Pärnu mnt 45. 1964. aastal valminud hoone arhitekt Ilmar Laasi. Renoveeritud interjööri autorid Pille Lausmäe, Kerli Lepp (Pille Lausmäe Sisearhitektuuri büroo). Projekti autorid Urmas Lõoke, Riina Poopuu (Urmas Lõokese Arhitektibüroo)

  20. Euroopa ühtlustab magistriõppe nõudeid / Karen Voolaid

    Index Scriptorium Estoniae

    Voolaid, Karen

    2003-01-01

    Helsingis, Bologna protsessi raames peetud magistritaseme hariduse teemalisel konverentsil töötati välja dokument, milles on kirjas magistriõppe peamised tunnusjooned Euroopa Ühtses Kõrgharidussüsteemis

  1. Euroopa ühtlustab magistriõppe nõudeid / Karen Voolaid

    Index Scriptorium Estoniae

    Voolaid, Karen

    2003-01-01

    2003. a. Helsingis Bologna protsessi raames peetud magistritaseme hariduse teemalisel konverentsil töötati välja dokument, milles on kirjas magistriõppe peamised tunnusjooned Euroopa Ühtses Kõrgharidussüsteemis

  2. Kuidas planeerida elamisväärset korterit? / Aet Piel ; intervjueerinud Karen Jagodin

    Index Scriptorium Estoniae

    Piel, Aet, 1966-

    2011-01-01

    Sisearhitekt Aet Piel halva planeeringuga vana korteri planeeringu muutmisest ja korteri kujundamisest. Hruštšovka-tüüpi korteri ümberplaneerimise võimalustest. Muudatuste tegemisest uues korteris. Köökidest

  3. Kino Kosmos Imax = Kosmos Imax cinema / Pille Lausmäe ; kommenteerinud Karen Jagodin

    Index Scriptorium Estoniae

    Lausmäe, Pille, 1958-

    2015-01-01

    Kino Kosmos Imax Tallinnas Pärnu mnt 45. 1964. aastal valminud hoone arhitekt Ilmar Laasi. Renoveeritud interjööri autorid Pille Lausmäe, Kerli Lepp (Pille Lausmäe Sisearhitektuuri büroo). Projekti autorid Urmas Lõoke, Riina Poopuu (Urmas Lõokese Arhitektibüroo)

  4. Neonatal intensive care in a Karen refugee camp: a 4 year descriptive study.

    Directory of Open Access Journals (Sweden)

    Claudia Turner

    Full Text Available BACKGROUND: A third of all deaths in children aged <5 years occur in the neonatal period. Neonatal intensive care is often considered too complex and expensive to be implemented in resource poor settings. Consequently the reductions that have been made in infant mortality in the poorest countries have not been made in the neonatal period. This manuscript describes the activities surrounding the introduction of special care baby unit (SCBU in a refugee setting and the resulting population impact. METHODS: A SCBU was developed in Maela refugee camp on the Thailand-Myanmar border. This unit comprised of a dedicated area, basic equipment, drugs and staff training. Training was built around neonatal guidelines, comprising six clinical steps: recognition, resuscitation, examination, supportive medical care, specialised medical care, and counselling of parents with sick newborns. RESULTS: From January 2008 until December 2011, 952 infants were admitted to SCBU. The main admission diagnoses were early onset neonatal sepsis, jaundice and prematurity. Early prematurity (<34 weeks carried the highest risk of mortality (OR 9.5, 95% CI 5.4-16.5, p<0.001. There was a significant decrease in mortality from 19.3% (2008 to 4.8% (2011 among the infants admitted for prematurity (p=0.03. The neonatal mortality in Maela camp as a whole declined by 51% from 21.8 to 10.7 deaths per 1000 live births over the corresponding period (p=0.04. Staff expressed more confidence in their ability to take care of neonates and there was a more positive attitude towards premature infants. CONCLUSION: Neonatal mortality can be reduced in a resource poor setting by introduction of a simple low cost unit specialising in care of sick neonates and run by local health workers following adequate training. Training in recognition and provision of simple interventions at a high standard can increase staff confidence and reduce fatalistic attitudes towards premature neonates.

  5. IP Tallinn 2003 - ühendab teadmised ja meelelahutuse / Karen Veidik, Katrin Tedder

    Index Scriptorium Estoniae

    Veidik, Karen

    2003-01-01

    EBSi eestvedamisel toimuvast rahvusvahelisest intensiivprogrammist, mille raames jagatakse üheksa ülikooli tudengitele teadmisi turundusest, läbirääkimise meetoditest ja kultuurieripäradest suhtlemises

  6. Autopsia : [arvustatakse eelmises Marduses ilmunud originaaljutte ja tõlkeid] / Karen Orlau

    Index Scriptorium Estoniae

    Orlau, Karen, pseud., 1975-

    2000-01-01

    Arvustatavad jutud: Smith, Clark Ashton. Öised koletised; Kalevipoeg, pseud. Purpurvalgus; Brown, Molly. Valel ajal; Belials, Veiko. Kunagi. Kuskil. Eikuskil; Lindsay, David. Swaylone'i saar; Hargla, Indrek. Obernoni apokrüüf

  7. Kuidas planeerida elamisväärset korterit? / Aet Piel ; intervjueerinud Karen Jagodin

    Index Scriptorium Estoniae

    Piel, Aet, 1966-

    2011-01-01

    Sisearhitekt Aet Piel halva planeeringuga vana korteri planeeringu muutmisest ja korteri kujundamisest. Hruštšovka-tüüpi korteri ümberplaneerimise võimalustest. Muudatuste tegemisest uues korteris. Köökidest

  8. Malaria and enterobiasis among Karen Long-neck tribe in Mae Hong Son Province.

    Science.gov (United States)

    Nithikathkul, Choosak; Polseela, Panida; Poodendan, Wilawan; Brodsky, Marc; Rakprapapant, Derek; Chadchatreechan, Suparp; Phethleart, Aree; Sukthana, Yaowalark; Leemingsawat, Somjai

    2003-01-01

    In Thailand, Mae Hong Son Province is highly endemic for malaria. Knowing this, the local Health Department has introduced a program to educate local residents about the risk factors, in particular the dangers and symptoms of malaria. This study was conducted to evaluate these efforts, by determining the number of malaria infections in a segment of the population, and also by testing for enterobiasis among a group of its children. Two villages in Mae Hong Son Province were chosen for this purpose with a combined population of about 300. Of these, 195 were screened for malaria. Two subjects were diagnosed positive for malaria by microscopy. One of these two villages was chosen to screen for Enterobius vermicularis infection in children as well. Out of 69 stool samples, five (7%) showed infection with E. vermicularis: three with a low number of eggs (1-50), and two with a high number of eggs (>100). Compared with infection rates in similar studies, the results of this study indicate that the Health Department's efforts are meeting with relative success. The low prevalence of infection indicates that the villagers are using the information they have received to help combat infection.

  9. Modernistlik ruumikontseptsioon ja nõukogude ideoloogia kohtuvad Viru hotellis / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Ajavahemikul 1964-1968 arhitektide Henno Sepmanni ja Mart Pordi poolt projekteeritud ning 1972. a. valminud Viru hotellist Tallinnas, põhjalikum ülevaade hoone interjöörist. Sisearhitektid Väino Tamm, Vello Asi, Taevo Gans, Mait Summatavet ja Loomet Raudsepp. II korruse naiste juuksuri ruumid kujundas Kirsti Laanemaa. II korruse banketisaalis oli Mari Adamsoni gobelään "Tare", suures restoranisaalis Aet Andresma-Tamme ja Mare Soovik-Lobjakase klaaskompositsioon "Pilved", Viru väljakul Edgar Viiese skulptuur "Merepiiga" (1981)

  10. MM Arimi, B.Sc, Institute of Primate Research, PO Box 24481, Karen ...

    African Journals Online (AJOL)

    2006-02-02

    Feb 2, 2006 ... This fusion process is associated with the ... with the following monoclonal antibodies: anti-ERV3 env (a), anti-HERV-Kenv (b), anti-Vimentin (positive control, ..... Characterization of antigens expressed in normal baboon.

  11. IP Tallinn 2003 - ühendab teadmised ja meelelahutuse / Karen Veidik, Katrin Tedder

    Index Scriptorium Estoniae

    Veidik, Karen

    2003-01-01

    EBSi eestvedamisel toimuvast rahvusvahelisest intensiivprogrammist, mille raames jagatakse üheksa ülikooli tudengitele teadmisi turundusest, läbirääkimise meetoditest ja kultuurieripäradest suhtlemises

  12. Raikküla mõisa ait-kuivatist ja selle taastamisest / Karen Klandorf

    Index Scriptorium Estoniae

    Klandorf, Karen

    2014-01-01

    Täpne valmimisaeg ei ole teada, kuid 1864. aastal on mainitud seda kui vana hoonet. 1909. aastal ehitati juurde kuivati. Mõisa ait-kuivati on traditsiooniline ehitis, mille muudavad erandlikuks pikkkaaristu ja hoone katusel ilutsev kellatorn. Kuivati esindab üht levinumat kuivatitüüpi. Restaureerimistööd kestsid 2008-2013.

  13. Diplomaatiline asüül : [bakalaureusetöö] / Karen Tikenberg ; Tartu Ülikool, õigusteaduskond ; juhendaja: Raul Narits

    Index Scriptorium Estoniae

    Tikenberg, Karen

    2002-01-01

    Asüüli ja asüüliõiguse terminoloogia ning olemus, diplomaatilise asüüli ajalooline areng, asüül diplomaatilises esinduses ja diplomaatilise asüüli printsiibid, õigus diplomaatilisele asüülile

  14. Laiahaardeline maailma rahvaste klaaskäsitöö näitus on Tallinnas / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Näitus maailma rahvaste klaashelmestest Eesti Tarbekunsti- ja Disainimuuseumis. Näitusel on ka klaashelmestega tarbeesemeid ja tänapäevaseid autorihelmeid Eestist, USA-st, Saksamaalt, Rootsist, Soomest ja Itaaliast. Näituseeksponaate Taani erakollektsionääri Torben Sode kogust

  15. An application of the interpersonal models developed by Karen Horney and Timothy Leary to type A-B behavior patterns.

    Science.gov (United States)

    Roemer, W W

    1987-01-01

    Using Horney's clinical concepts and Leary's circle matrix procedures, this study investigated the Type A and B patterns of personality. Significant findings showed the Type A-B continuum to represent two distinct poles, with the Type A direction reflecting the expansive personality pattern (power and aggressiveness) and the Type B direction reflecting the self-effacing pattern (helplessness and affiliation) for self-perceived roles. For behavioral roles, the power-versus-helplessness traits described the two contrasting directions of personality involvement. Three subgroups were identified for behavioral role in each A and B extreme group. The shift in affect between the ACL and MMPI instruments may reflect two factors: the degree of ambiguity set up by the nature of the tests and the responding "pull" of the individual, which was described as an "active" or "quiescent" form of the A and B patterns. Hence, it may be more effective to diagnose individuals in terms of a specific behavioral subtype and active or quiescent enactments. Three maladjustment indicators were investigated. Significant findings showed the A2 group as exhibiting increasing rigidity of behavioral role with lower Type A scores and the A1 group as exhibiting greater discrepancies with increasing Type A scores. The lack of discrepancy for the Type B groups may reflect a dysfunction in that these individuals may be stagnated in their work situations and complacent in the docile-dependent role. The three findings of behavioral subgroups, rigidity of role, and discrepancy were discussed as possible mediating psychosocial factors associated with coronary heart disease. Since this was the first major examination and use of Leary's model (to the author's knowledge) since the late 1950s, it is important to consider these results tentative and heuristic, until replications can be conducted. It is hoped that representative norms from diverse samples can be obtained for developing standard scores on Leary's circle matrix axes. The present study was limited by the narrow demographic characteristics of its subjects, who were mostly white-collar workers in professional, technical, or management positions.

  16. Diplomaatiline asüül : [bakalaureusetöö] / Karen Tikenberg ; Tartu Ülikool, õigusteaduskond ; juhendaja: Raul Narits

    Index Scriptorium Estoniae

    Tikenberg, Karen

    2002-01-01

    Asüüli ja asüüliõiguse terminoloogia ning olemus, diplomaatilise asüüli ajalooline areng, asüül diplomaatilises esinduses ja diplomaatilise asüüli printsiibid, õigus diplomaatilisele asüülile

  17. Barnkonventionens föregångare. Anteckningar om den polske barnläkaren och pedagogen Janusz Korczak

    Directory of Open Access Journals (Sweden)

    Sven G Hartman

    2001-01-01

    Full Text Available The Polish paediatrician and educationalist Janusz Korczak ( Henryk Goldszmit 1878-1942 is one of the great names in the progressive wave in the decades around the First World War. International interest in Korczak is focusing on his many-sided work as an author, physician, educationalist and advocate of children’s rights. He was also one of the martyrs of the Holocaust. His work is one of the inspirations of the UN Convention on the Rights of Children. This paper focuses on different professional dimensions of educational work as described by Korczak: practice, basic values and educational science. It also deals with Korczak as a typical representative of modernity in medicine and education. Zygmunt Bauman’s view on modernity and Holocaust is applied on Korczak’s work. You can find similarities between Korczak and the Nazi doctors, for instance. But there is also a crucial difference connected to the moral dimensions of professional work. Respect for humanity and respect for children is a fundamental principal in the writings of Korczak. His thoughts about children’s right to respect are original and still worth reading.

  18. Laiahaardeline maailma rahvaste klaaskäsitöö näitus on Tallinnas / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Näitus maailma rahvaste klaashelmestest Eesti Tarbekunsti- ja Disainimuuseumis. Näitusel on ka klaashelmestega tarbeesemeid ja tänapäevaseid autorihelmeid Eestist, USA-st, Saksamaalt, Rootsist, Soomest ja Itaaliast. Näituseeksponaate Taani erakollektsionääri Torben Sode kogust

  19. ZELIZER, Barbie y TENENBOIM-WEINBLATT, Karen (Edit. (2014, Journalism and Memory, Croydon, Palgrave MacMillan, 2014

    Directory of Open Access Journals (Sweden)

    Manuel Javier Callejo Gallego

    2015-01-01

    Full Text Available El periodismo vuelto del revés, mirando hacia atrás, como repositorio de lo que ha pasado. Reflexionar sobre tal reversión es el objetivo del libro editado por Zelizer y Tenenboim-Weinblatt. Un juego oportuno que permite, en su estado actual, la diversidad de miradas que presenta este texto y, por lo tanto, la desigualdad en los enfoques.

  20. Unustage töö ja eraelu tasakaal - seda pole olemas / Karen Schmidt ; kommenteerinud Adrian Furnham, Milvi Tepp

    Index Scriptorium Estoniae

    Schmidt, Karen

    2014-01-01

    Viimaste uuringute kohaselt ei eksisteeri tänapäeva maailmas tasakaalu töö ja eraelu vahel, töö ja eraelu on põimunud - töööajal aetakse isiklikke asju, vaba aega kasutatakse töö tegemiseks. Üle-euroopalisest Samsungi töötajate uuringust

  1. Unustage töö ja eraelu tasakaal - seda pole olemas / Karen Schmidt ; kommenteerinud Adrian Furnham, Milvi Tepp

    Index Scriptorium Estoniae

    Schmidt, Karen

    2014-01-01

    Viimaste uuringute kohaselt ei eksisteeri tänapäeva maailmas tasakaalu töö ja eraelu vahel, töö ja eraelu on põimunud - töööajal aetakse isiklikke asju, vaba aega kasutatakse töö tegemiseks. Üle-euroopalisest Samsungi töötajate uuringust

  2. Miks sa nii palju ostad? Igapäevane turundus / Tuuli Elstrok

    Index Scriptorium Estoniae

    Elstrok, Tuuli

    2011-01-01

    Tarbimine kui emotsionaalne tegevus tingib turunduskommunikatsiooni ja reklaami keskendumise emotsioonidele. Loo aluseks on TÜ majandusteaduskonna doktorandi ja turunduse õppejõu Tanel Mehise ettekanne

  3. Tänapäevane ostukampaania ei narri klienti / Kaidi Laur

    Index Scriptorium Estoniae

    Laur, Kaidi

    2008-01-01

    Allahindluskampaaniates kasutatavatest turundusvõtetest. Autori hinnangul peaksid kaubanduskeskused oma kampaaniates kasutama ausamat ja kliendisõbralikumat kontseptsiooni, mis väärtustavad klienti ja pakuvad kvaliteetseid ning vajalikke kaupu soodsa hinnaga

  4. Hypertension during chronic exposure to cold: Comparison between Sprague Dawley (SD) and Long Evans (LE) strains

    Energy Technology Data Exchange (ETDEWEB)

    Riesselmann, A.; Baron, A.; Fregly, M.J. (Univ. of Florida, Gainesville (United States))

    1991-03-11

    Hypertension accompanies chronic exposure of SD rats to cold (5-6C), including elevation of systolic, diastolic, and mean blood pressures and cardiac hypertrophy. The renin-angiotensin system may play an important role. Earlier studies suggested that the LE strain may have a decrease in angiotensin I converting enzyme (ACE) activity. Measurement of ACE activity in plasmas of SE and LE strains revealed that basal activity of ACE in the plasma of the LE strain was significantly less than that of the SD strain. A second study was carried out in which both strains were exposed to cold for 7 weeks. There were clear differences between strains. Rats of the SD strain had a significant elevation in their blood pressure; a significantly increased urinary output of norepinephrine (NE) and epinephrine (E); and significant increases in weights of heart, kidneys, adrenals, and brown adipose tissue (IBAT) compared to their controls maintained at 26C. In contrast, rats of the LE strain were less responsive to cold in that blood pressure failed to rise as sharply and to attain as high a level; NE and E outputs, as well as weights of heart and IBAT were significantly less than those of rats of the cold-treated SD strain. Thus, the lower ACE activity in plasma of LE strain, as well as a reduced secretion of catecholamines, may protect these rats against the rise of blood pressure characteristically observed when rats of the SD strain are exposed to cold.

  5. Exposure to Novelty Weakens Conditioned Fear in Long-Evans Rats

    Science.gov (United States)

    Anderson, Matthew J.; Burpee, Tara E.; Wall, Matthew J.; McGraw, Justin J.

    2013-01-01

    The present study sought to determine whether post-training exposure to a novel or familiar object, encountered in either the location of the original fear conditioning (black compartment of a passive avoidance {PA} chamber) or in a neutral setting (open field where initial object training had occurred) would prove capable of reducing fear at…

  6. Ajaleheturul on 70% allahindlus igapäevane / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Selle asemel, et ametlikult reklaamihinda langetada pakuvad ajalehed reklaamiandjatele ülisuuri soodustusi. Kommenteerivad Enn Parel, Aavo Kokk, Andrus Vaher, Priit Leito, Erik Roose, Ruta Kallaspoolik, Toomas Tiivel, Lauri-Hillar Talve

  7. Utilization Management of Orthopedic Services by Fitzsimons Army Medical Center and Evans Army Community Hospital

    Science.gov (United States)

    1993-08-01

    Nerve & Other Nerve System Proc w CC 1 2.72 2.0 -10.0 -10 209 Major Joint & Limb reattachment Procedures, lower Extremity 18 2.37 13.6 3.6 65 216...106 3.0 1.0 108 209 Major Joint & Limb Reattachment Procedures Lower Extremity 101 20.9 10.9 1105 243 Medica. Back Problems 65 9.0 4.0 261 231 Local...231 Local Excision & Removal of Int. Fix Devices exc Hip & Femur 74 4.6 0.6 41 209 Major Joint & Limb Reattachment Procedures Lower Extremity 70 22.3

  8. Proteins Associated with the Termination of Ocular Dominance Column Plasticity in Long Evans Rats

    Institute of Scientific and Technical Information of China (English)

    Junping Yao; Zhengqin Yin; Shijun Wang

    2007-01-01

    Purpose: To investigate the mechanism of the termination of ocular dominance column plasticity by electrophysiologic analysis and 2-dimensional electrophoresis-mass spectrography (2-DE/MS).Methods: The changes in ocular dominance columns following monocular deprivation were electrophysiologically detected in 22-day-old, 100-day-old and chondroitinaseperfused 100-day-old rats. Total protein of grey matter of the primary visual cortex was extracted and studied by 2-DE/MS from the three groups of rats.Results: Monocular deprivation may lead to shifts in ocular dominance columns in 22-day-old and chondroitinase-perfused 100-day-old rats, but not in 100-day-old rats. Four protein spots present in grey matter of the primary visual cortex in 100-day-old, but not in that of 22-day-old and chondroitinase-perfused rats, and mass spectrography identified two of these proteins.Conclusions: The electrophysiologic results show that ocular dominance column plasticity presents in 22-day-old rats, ends up in 100-day-old rats and restored in chondroitinaseperfused 100-day-old rats. 2-DE/MS results show that phosphatidylethanolamine binding protein and glial fibrillary acidic protein delta may be associated with the termination of ocular dominance column plasticity in the rat, but need more evidence to confirm it.

  9. Absence of diurnal variation in visceromotor response to colorectal distention in normal Long Evans rats

    NARCIS (Netherlands)

    Botschuijver, Sara; Yu, Zhumei; Welting, Olaf; Cailotto, Cathy; Kalsbeek, A.; van den Wijngaard, Rene

    2016-01-01

    BACKGROUND: Enhanced colorectal sensitivity (i.e. visceral hypersensitivity) is thought to be a pathophysiological mechanism in irritable bowel syndrome (IBS). In healthy men a circadian variation in rectal perception to colonic distention was described. Disturbed day and night rhythms, which occur

  10. A word from Lyn Evans:
    A sprint to the finish

    CERN Multimedia

    2008-01-01

    Most people consider that the starting point for the LHC was a meeting organised by the European Committee for Future Accelerators in Lausanne in March 1984, even though quite a few of us at CERN had already begun work on the design in 1981. Since that time this truly unique machine has moved from a dream to a reality. With its ‘two in one’ magnet structure cooled by superfluid helium for operation at 1.9 K, the LHC is like no other particle collider. In a very real sense, the LHC is its own prototype. Other colliders have either consisted of two rings to accelerate and store two beams of particles, as in the Intersecting Storage Rings (ISR) here at CERN, or they have stored particles and their antiparticles travelling in opposite directions with a single ring, as we did with the Large Electron-Positron (LEP) collider. In addition, the LHC is the first accelerator in which the superconducting magnets have been cooled as low as 1...

  11. Ülev ja igapäevane = The sublime and the everyday / Kaja Pae

    Index Scriptorium Estoniae

    Pae, Kaja

    2015-01-01

    Eesti linnade suurima elanike tihedusega piirkonnad on vabaplaneeringu alad. Paneelelamupiirkondade avalik ruum on jäänud lõpetamata, valmis on ehitatud kortermajad, koolid ja lasteaiad ning suurem infrastruktuur, kuid majadevahelise vaba ruumi täpsema läbimõtestamiseni pole jõutud.Tartu linnavalitsus korraldas 2014. aastal Annelinna visioonikonkursi, et planeeringulisi võimalusi edasi arendada ja avalikku ruumi parandada.

  12. Acute triadimefon-induced changes in the EEG of Long-Evans Rats

    Science.gov (United States)

    We have reported that the non-stimulus driven EEG is altered differently by acute treatment with deltamethrin, permethrin, fipronil, or imidacloprid (Lyke and Herr, Lyke et al., Toxicologist, 2010, 2011, 2012) in non-restrained animals. In the current study, we examined the abili...

  13. Effects produced by single and repeated dosages of Fipronil on the EEG of Long Evans Rats

    Science.gov (United States)

    We have previously reported that various classes of pesticides have different effects on the non- stimulus driven EEG after acute treatment, including fipronil (25 or 50 mg/kg) (Lyke et a!., Toxicologist, 2010, 2011, 2012, 2013). In this study, we compared the effects of single a...

  14. IMIDACLOPRID PRODUCES MINIMAL CHANGES IN THE EEG OF LONG-EVANS RATS

    Science.gov (United States)

    We have reported that the non-stimulus driven EEG is differentially altered by deltamethrin or permethrin (Lyke and Herr, Toxicologist, 114(S-1) :265, 2010) as well as fipronil (Lyke and Herr, Toxicologist, 120(S-2) :290, 2011). In the current study, we examined the ability to de...

  15. Effects produced by single and repeated dosages of Fipronil on the EEG of Long Evans Rats

    Science.gov (United States)

    We have previously reported that various classes of pesticides have different effects on the non- stimulus driven EEG after acute treatment, including fipronil (25 or 50 mg/kg) (Lyke et a!., Toxicologist, 2010, 2011, 2012, 2013). In this study, we compared the effects of single a...

  16. DCS Hydrology Submission for Evans County GA MapMod08

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  17. Thermoregulatory deficits in adult long evans rat offspring exposed perinatally to the antithyroidal drug, propylthiouracil

    Science.gov (United States)

    Developmental exposure to endocrine disrupting toxicants has been shown to alter a variety of physiological processes in mature offspring. Body (core) temperature (Tc) is a tightly regulated homeostatic system but is susceptible to disruptors of the hypothalamic-pituitary-thyroid...

  18. Inpatient Behavioral Health Recapture A Busiess Case Analysis at Evans Army Community Hospital Fort Carson, Colorado

    Science.gov (United States)

    2009-07-20

    68 Appendix B: Personnel Data 70 Automated Staffing Assessment Model ( ASAM ) 70 Fort Hood MEPRS 73 Salary.com Rates 77 Appendix C: Financial...health units. The closest information available comes from the Automated Staffing Assessment Model ( ASAM ), which considers this service largely a nursing...function. Therefore, the ASAM model utilizes the Workload Management System for Nursing (WMSN) to assist in determining suggested nursing staffing

  19. Ülev ja igapäevane = The sublime and the everyday / Kaja Pae

    Index Scriptorium Estoniae

    Pae, Kaja

    2015-01-01

    Eesti linnade suurima elanike tihedusega piirkonnad on vabaplaneeringu alad. Paneelelamupiirkondade avalik ruum on jäänud lõpetamata, valmis on ehitatud kortermajad, koolid ja lasteaiad ning suurem infrastruktuur, kuid majadevahelise vaba ruumi täpsema läbimõtestamiseni pole jõutud.Tartu linnavalitsus korraldas 2014. aastal Annelinna visioonikonkursi, et planeeringulisi võimalusi edasi arendada ja avalikku ruumi parandada.

  20. PLA Philosophy, Policy, and Practice Implications: Revisiting the 2009 Hoffman, Travers, Evans, and Treadwell Study

    Science.gov (United States)

    Travers, Nan L.

    2013-01-01

    The heart of prior learning assessment (PLA) is the quality and validity of the academic evaluation process itself. Institutions providing PLA opportunities are faced with issues of accountability from all constituents: students, faculty, state systems, and accrediting agencies. Increasingly, institutions are more and more accepting of different…

  1. Charles Bazerman on John Swales: An Interview with Tony Dudley-Evans.

    Science.gov (United States)

    Dudley-Evans, Tony

    1998-01-01

    An interview with a colleague of linguist John Swales focuses on Swales' career study of English for Specific Purposes (ESP), particularly genre analysis and ESP and the growing interaction of two field, ESP for non-native speakers and composition studies, usually concerned with native speakers. Specific contributions made by Swales to the fields…

  2. Toluene Inhalation Exposure for 13 Weeks Causes Persistent Changes in Electroretinograms of Long-Evans Rats

    Science.gov (United States)

    Studies of humans chronically exposed to volatile organic solvents have reported impaired visual functions, including low contrast sensitivity and reduced color discrimination. These reports, however, lacked confirmation from controlled laboratory experiments. To addre...

  3. Quantum Random Walks and their Convergence to Evans-Hudson Flows

    Indian Academy of Sciences (India)

    Lingaraj Sahu

    2008-08-01

    Using coordinate-free basic operators on toy Fock spaces, quantum random walks are defined following the ideas of Attal and Pautrat. Extending the result for one dimensional noise, strong convergence of quantum random walks associated with bounded structure maps to Evans–Hudson flow is proved under suitable assumptions. Starting from the bounded generator of a given uniformly continuous quantum dynamical semigroup on a von Neumann algebra, we have constructed quantum random walks which converges strongly and the strong limit gives an Evans–Hudson dilation for the semigroup.

  4. VizieR Online Data Catalog: High-resolution imaging of TEP systems (HITEP) (Evans+, 2016)

    Science.gov (United States)

    Evans, D. F.; Southworth, H.; Maxted, P. F. L.; Skottfelt, J.; Hundertmark, M.; Jorgensen, U. G.; Dominik, M.; Alsubai, K. A.; Andersen, M. I.; Bozza, V.; Bramich, D. M.; Burgdorf, M. J.; Ciceri, S.; D'Ago, G.; Figuera Jaimes, R.; Gu, S. H.; Haugbolle, T.; Hinse, T. C.; Juncher, D.; Kains, N.; Kerins, E.; Korhonen, H.; Kuffmeier, M.; Peixinho, N.; Popovas, A.; Rabus, M.; Rahvar, S.; Schmidt, R. W.; Snodgrass, C.; Starkey, D.; Surdej, J.; Tronsgaard, R.; von Essen, C.; Wang, Y. B.; Wertz, O.

    2016-03-01

    Table 1 contains the summary of observations undertaken in this work, listing each observation, the target, and exposure time in one (red) or two (red and visible) cameras. Table 4 contains a set of distances derived to the exoplanet host stars, using the K-band calibration of Kervella et al. (2004A&A...426..297K). Table 8 gives the raw measurements of each detected companion on each observation, which include observing date, separation and position angle, and magnitude relative to the exoplanet host star in one (red) or two (red and visible) cameras. (3 data files).

  5. DCS Hydraulics Submission for Evans County GA MapMod08

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  6. Graduate Management Project: Optimizing Cardiology and Radiology Services at Evans Army Community Hospital

    Science.gov (United States)

    2004-01-01

    and Patient Safety and Near Miss guidance will benefit the community served. Soldier and their families will be cared for at EACH and not within the...Guideline metrics, Evidenced Based Medicine metrics and Patient Safety and Near Miss guidance metrics? (1) Network (Purchased Care) Cost (2) Network...Guidelines, Evidenced Based Medicine and Patient Safety and Near Miss issues. N/A 6.0 Link to BSC Strategy

  7. Moniliophthora roreri (Cif y Par Evans et al. en el cultivo de cacao

    Directory of Open Access Journals (Sweden)

    Fernando David Sánchez Mora

    2012-01-01

    Full Text Available Más de un siglo, el cacao (Theobroma cacaoL. en el Ecuador ha sido fuente importante de ingresos para losagricultoresy de divisas para el país, llegando a ser uno de los exportadores más grandes a nivel mundial.Posteriormente, perdió paulatinamente ese estatus debido al ataque de enfermedades, entre ellas la moniliasiscausada por [Moniliophthoraroreri(Cif y ParEvanset al.]. Esta enfermedad puede causar daños hasta del80% en la producción. Actualmente no existe mucha información actualizada y científica, sobre su ocurrencia,sintomatología, etiología, epidemiología, ciclo de vida y manejo o estrategias de controlde la mencionadaenfermedad, por la tanto se realiza esta revisión con estos tópicos importantes, aportando con esto a esta áreadel conocimiento.

  8. Jean Pierre Poulain et Edmond Neirinck, Histoire de la cuisine et des cuisiniers. Techniques culinaires et pratiques de table, en France, du Moyen Âge à nos jours

    Directory of Open Access Journals (Sweden)

    Isabelle Techoueyres

    2005-05-01

    Full Text Available This book is the 5th edition of the work published in 1988, which received the Award of the Académie Nationale de Cuisine the same year. This new edition, enriched and entirely rethought, is aimed at both professionals in the field of cuisine and a general public amateur of gastronomy. It is prefaced by the French chef Joel Robuchon.The major characteristic of the work is the complementary approach by authors who combine disciplines: J.P. Poulain is an anthropo sociologist, professor in the s...

  9. 2004 Fellows Citations

    Science.gov (United States)

    2004-04-01

    AGU congratulates the forty-one distinguished scientists who were selected by a committee of their peers to be AGU Fellows for 2004. This selection was based on the individuals' attainment of acknowledged eminence in a branch of geophysics. The number of Fellows selected annually is limited to no more than 0.1% of the AGU membership: Andrew D. Barry, Enrico Bonatti, Edward V. Bromwell, John P. Burrows, Philip R. Christensen, William B. Curry, Judith Curry, Margaret L. Delaney, Steven R. Emerson, Brian J. Evans, Donald H. Fairfield, Marvin Geller, David Green, William Holt, Roy Hyndman, David E. James, James F. Kasting, Peter Kelemen, Paul J. Kellogg, Michael J. Kirkby, Daniel Loucks, P.M. Mathews, Jean-Paul Montagner, William R. Normark, Gerald R. North, Michael O'Hara, Ronald S. Oremland, Roger A. Pielke, Sr., Joseph Prospero, Karsten Pruess, Edmond C. Roelof, Gary Rottman, Allan Rubin, Ernest H. Rutter, John H. Seinfeld, Sharon Smith, Pieter Tans, John M. Toole, Jean-Pierre Valet, Lionel Wilson, and E. L. Winterer

  10. Social Networking and the School Adjustment of Karen Refugee Youth from Burma: Determining the Effects of Ethnic Identity, Bonding Social Capital, and Facebook Use

    Science.gov (United States)

    Lewis, Lucy D.

    2013-01-01

    In 2011 alone, over 56,000 refugees were admitted to the United States and a third of these individuals were under the age of 18 (Martin & Yankay, 2012). Researchers have found that the social capital developed through close and confiding relationships is instrumental in the academic outcomes of refugee youth (Kia-Keating & Ellis, 2007;…

  11. Pamela Moss, Karen Falconer Al-Hindi (Hg.: Feminisms in Geography. Rethinking Space, Place, and Knowledges. Lanham u.a.: Rowman & Littlefield Publishers 2008.

    Directory of Open Access Journals (Sweden)

    Katharina Fleischmann

    2009-11-01

    Full Text Available Im Mittelpunkt des Sammelbandes steht die Produktion und Formation feministisch-geographischen Wissens im internationalen Kontext. Um dies nachzuzeichnen, versammeln die Herausgeberinnen einerseits Nachdrucke ausgewählter Artikel und andererseits aktuelle Beiträge internationaler Wissenschaftlerinnen, die die theoretische und inhaltliche Bandbreite feministischer Geographien erkennen lassen. Thematisiert werden dabei feministische Interventionen in der Geographie, hegemoniale Strukturen innerhalb feministischer Geographien und feministisch-geographische Praxis.The production and formation of feminist geographic knowledge in an international context is central to this collected volume. The editors sketch this knowledge by combining reprints of select articles with current contributions from international scientists who identify a broad spectrum of feminist geographies in terms of theory and content. They thus thematize feminist interventions in geography, hegemonic structures within feminist geographies, and feminist-geographical practice.

  12. Synonymic notes on North and Central American Lerodea Scudder and Corticea Evans (Lepidoptera, Hesperiidae, Hesperiinae Notas sinonímicas sobre Lerodea Scudder and Corticea Evans das Américas do Norte e Central (Lepidoptera, Hesperiidae, Hesperiinae

    Directory of Open Access Journals (Sweden)

    Andrew D. Warren

    2005-03-01

    Full Text Available Lerodea dysaules Godman, 1900 is confirmed as a synonym of Lerodea arabus (W. H. Edwards, 1882. A lectotype for Lerodea dysaules is designated. Corticea similea (Bell, 1942, comb. nov. is removed from Lerodea Scudder, 1872.Lerodea dysaules Godman, 1900 é confirmada como sinônimo de Lerodea arabus (W. H. Edwards, 1882. Um lectótipo para Lerodea dysaules é designado. Corticea similea (Bell, 1942, comb. nov. é removida de Lerodea Scudder, 1872.

  13. INHIBITION OF BRAIN CHOLINESTERASE AND THE PHOTIC AFTER DISCHARGE OF FLASH EVOKED POTENTIALS PRODUCED BY CARBARYL IN LONG EVANS RATS.

    Science.gov (United States)

    Carbaryl is a widely used N-methyl carbamate pesticide that acts by inhibiting cholinesterases (ChE), which may lead to cholinergic toxicity. Flash evoked potentials (FEPs) are a neurophysiological response often used to detect central nervous system (CNS) changes following expos...

  14. The democratic experience in divided societies : the Baltic states in comparative perspective / Geoffrey Evans, Christine S Lipsmeyer

    Index Scriptorium Estoniae

    Evans, Geoffrey

    2001-01-01

    Artiklis võrreldakse vähemusrahvuste rahulolu demokratiseerimisprotsessiga ning osalemist demokraatlikes protsessides kolmes Balti riigis ning kümnes Ida-Euroopa riigis 1990. aastail. Tabelid. Lisa: The surveys

  15. Dermatomiositis y síndrome de Evans asociado a infección por HTLV-1

    OpenAIRE

    David Loja-Oropeza; Ernesto Zavala-Flores; Maricela Vilca-Vasquez

    2016-01-01

    A 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Upon admission, she was drowsy, with a poor overall status, marked weight loss, dehydration, with presence of livedo reticularis in her lo...

  16. 3-päevane üliõpilastöö - "Roheline lava" = 3-day student project - "Green stage"

    Index Scriptorium Estoniae

    2008-01-01

    Tutvustatakse Tallinna Tehnikakõrgkooli Arhitektuuri õppetooli õpitoa "Intelligentsed konstruktsioonid" raames 4. kursuse arhitektuuri ja ehituse eriala üliõpilaste kavandatud 11 "Rohelise lava" lahendust Tallinna lauluväljaku maa-alale. Üliõpilasi juhendasid Irina Raud ja Stefan Polonyi (Saksamaa)

  17. Effects of Exercise Training and Social Environment on Stress Resilience in Male and Female Long-Evans Rats

    Science.gov (United States)

    2010-03-15

    dysfunction. American Journal of Cardiology , 95, 322-326. Alleva, E., & Santucci, D. (2001). Psychosocial vs. “physical” stress situations in rodents and...alleviation of learned helplessness in dogs . Journal of Abnormal Psychology, 73, 256-262. Selye, H. (1946). The general adaptation syndrome and the

  18. Acute and subchronic toxicity of inhaled toluene in male Long Evans rats: oxidative stress markers in brain

    Data.gov (United States)

    U.S. Environmental Protection Agency — Research interested in oxidative stress markers following exposure to VOCs. This dataset is associated with the following publication: Kodavanti , P., J. Royland ,...

  19. Dermatomiositis y síndrome de Evans asociado a infección por HTLV-1

    OpenAIRE

    David Loja-Oropeza; Ernesto Zavala-Flores; Maricela Vilca-Vasquez

    2016-01-01

    Paciente mujer de 55 años de edad, natural de Ayacucho, con antecedente de dermatomiositis desde hace 3 años, recibió tratamiento irregular con prednisona. Dos meses antes del ingreso presenta anemia hemolítica autoinmune y púrpura trombocitopénica idiopática, recibió pulsos de metilprednisolona y transfusión de paquetes globulares. Al ingreso, soporosa, mal estado general, marcada pérdida ponderal, deshidratada, livedo reticularis en miembros inferiores, onicodistrofia y onicolisis múltiple ...

  20. Stress facilitates late reversal learning using a touchscreen-based visual discrimination procedure in male Long Evans rats

    OpenAIRE

    Bryce, Courtney A.; Howland, John G.

    2014-01-01

    The stress response is essential to the survival of all species as it maintains internal equilibrium and allows organisms to respond to threats in the environment. Most stress research has focused on the detrimental impacts of stress on cognition and behavior. Reversal learning, which requires a change in response strategy based on one dimension of the stimuli, is one type of behavioral flexibility that is facilitated following some brief stress procedures. The current study investigated a po...

  1. Adolescent social instability stress increases aggression in a food competition task in adult male Long-Evans rats.

    Science.gov (United States)

    Cumming, Mark J; Thompson, Madison A; McCormick, Cheryl M

    2014-11-01

    Adolescent social instability stress (SS; daily 1 hr isolation + new cage partners postnatal days 30-45; thereafter with original cage partner, also in the SS condition) and control (CTL) rats competed for access to a preferred food in five sessions against their cage partner. In the first session, SS pairs displayed more aggression (face whacks, p = .02; rear attacks, p = .03), were less likely to relinquish access to the food voluntarily (p = .03), spent more time at the feeder than CTL pairs (p = .06), but did not differ in latency to access the feeder (p = .41). Pairs were considered in dominant-submissive relationships (DSR) if one rat spent significantly more time at the feeder than the other; 8 of 12 SS and 8 of 12 CTL pairs displayed DSRs (remaining: no-DSR). Aggression increased from the 1st to 5th session (p aggression in groups), and was higher in SS than CTL pairs (p = .05). Because the increased aggression of SS compared with CTL pairs did not result in a significant increase in their time at the feeder, the increased aggression may be considered maladaptive, and may reflect an increased motivation for food reward. These results add to evidence that SS in adolescence modifies the adult social repertoire of rats and highlight the importance of adolescent social experiences for adult behavior.

  2. VizieR Online Data Catalog: c2d Spitzer final data release (DR4) (Evans+, 2003)

    Science.gov (United States)

    Evans, N. J., II; Allen, L. E.; Blake, G. A.; Boogert, A. C. A.; Bourke, T.; Harvey, P. M.; Kessler, J. E.; Koerner, D. W.; Lee, C. W.; Mundy, L. G.; Myers, P. C.; Padgett, D. L.; Pontoppidan, K.; Sargent, A. I.; Stapelfeldt, K. R.; van Dishoeck, E. F.; Young, C. H.; Young, K. E.

    2014-05-01

    This is the final delivery (DR4, Fall 2006 and Fall 2007) of the Spitzer Space Telescope "From Molecular Cores to Planet-Forming Disks" (c2d) Legacy Project. The data are also available as Enhanced Products from the Spitzer Science Center (SSC). c2d has delivered 867 catalogs. IRSA has merged these delivered catalogs into four groups - Clouds, Off-Cloud, Cores, Stars - and serves them through the general catalog search engine Gator. Many of the delivered catalogs, images and spectra are accessible through IRSA's general search service, Atlas. As a service to its users, the CDS has downloaded a dataset containing most of the c2d data (but not all columns) from the IRSA archive. The individual catalogs are listed below: C2D Fall '07 Full CLOUDS Catalog (CHA_II, LUP, OPH, PER, SER) C2D Fall '07 High Reliability (HREL) CLOUDS Catalog (CHA_II, LUP, OPH, PER, SER) C2D Fall '07 candidate Young Stellar Objects (YSO) CLOUDS Catalog (CHA_II, LUP, OPH, PER, SER) C2D Fall '07 Full OFF-CLOUD Catalog (CHA_II, LUP, OPH, PER, SER) C2D Fall '07 candidate Young Stellar Objects (YSO) OFF-CLOUD Catalog (CHA_II, LUP, OPH, PER, SER) C2D Fall '07 Full CORES Catalog C2D Fall '07 candidate Young Stellar Objects (YSO) CORES Catalog C2D Fall '07 Full STARS Catalog C2D Fall '07 candidate Young Stellar Objects (YSO) STARS Catalog These tables have been merged into a single table at CDS. All three SIRTF instruments (Infrared Array Camera [IRAC], Multiband Imaging Photometer for SIRTF [MIPS], and Infrared Spectrograph [IRS]) were used to observe sources that span the evolutionary sequence from molecular cores to protoplanetary disks, encompassing a wide range of cloud masses, stellar masses, and star-forming environments. (1 data file).

  3. Hesperiidae of Rondônia, Brazil: Cephise Evans (Pyrginae), with descriptions of new species from Mexico and Brazil

    National Research Council Canada - National Science Library

    George T. Austin; Olaf H.H. Mielke

    2000-01-01

    ... sp.n. from Oaxaca and San Luis Potosi, Mexico. In the "procerus" group are included: Cephise procerus (Plötz, 1880); Cephise aelius (Plötz, 1880) sp. reval.. comb.n.. with its synonyms Eudamus auginulus Godman...

  4. Sex differences in diazepam effects and parvalbumin-positive GABA neurons in trait anxiety Long Evans rats.

    Science.gov (United States)

    Ravenelle, Rebecca; Neugebauer, Nichole M; Niedzielak, Timothy; Donaldson, S Tiffany

    2014-08-15

    In clinical populations, prevalence rates for a number of anxiety disorders differ between males and females and gonadal hormones are thought to contribute to these differences. While these hormones have been shown to modulate the anxiolytic effects of the benzodiazepine agonist diazepam in some models, findings are inconsistent. Here, we tested for sex differences in response to anxiogenic stimuli following a 30-min diazepam (1.0mg/kg) pre-treatment in male and female rats showing high (HAn) and low (LAn) anxiety-like behavior on the elevated plus maze. Acute diazepam administration resulted in decreased anxiety-like behavior only in HAn males as demonstrated by a significant increase in percent open arm time in the elevated plus maze (EPM). Immunohistochemical analysis for parvalbumin (PV; a calcium-binding protein that selectively stains GABAergic neurons) in central amygdala (CeA), caudate putamen (CPu) and the hippocampus indicated the number of GABAergic interneurons in these areas differed across sex and anxiety trait. In the CPu, females had significantly more PV-immunoreactive (IR) cells than males, and LAn females had greater PV-IR neurons than HAn females. In the CeA, males displayed an increased number of PV-IR neurons compared to females, with no differences found between LAn and HAn. Further, trait differences were evident in the CA2 region of the hippocampus, regardless of sex. Taken together, these data suggest that gonadal hormones and trait anxiety may influence the sensitivity to the anti-anxiety effects of diazepam and these differences may be due in part to the distribution of GABA-containing interneurons.

  5. Exposure to methylphenidate during peri-adolescence affects endocrine functioning and sexual behavior in female Long-Evans rats.

    Science.gov (United States)

    Guarraci, Fay A; Holifield, Caroline; Morales-Valenzuela, Jessica; Greene, Kasera; Brown, Jeanette; Lopez, Rebecca; Crandall, Christina; Gibbs, Nicole; Vela, Rebekah; Delgado, Melissa Y; Frohardt, Russell J

    2016-03-01

    The present study was designed to test the effects of methylphenidate (MPH) exposure on the maturation of endocrine functioning and sexual behavior. Female rat pups received either MPH (2.0mg/kg, i.p.) or saline twice daily between postnatal days 20-35. This period of exposure represents the time just prior to puberty as well as puberty onset. Approximately five weeks after the last injection of MPH or saline, female subjects were hormone-primed and tested during their first sexual experience. Subjects were given the choice to interact with a sexually active male or a sexually receptive female rat (i.e., the partner-preference test). The partner-preference paradigm allows us to assess multiple aspects of female sexual behavior. MPH exposure during peri-adolescence delayed puberty and, when mated for the first time, affected sexual behavior (e.g., increased time spent with the male stimulus and decreased the likelihood of leaving after mounts) during the test of partner preference. When monitoring estrous cyclicity, female subjects treated with MPH during peri-adolescence frequently experienced irregular estrous cycles. The results of the present study suggest that chronic exposure to a therapeutic dose of MPH around the onset of puberty alters long-term endocrine functioning, but with hormone priming, increases sensitivity to sexual stimuli. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Paper or Plastic? Exploring the Effects of Natural Enrichment on Behavioural and Neuroendocrine Responses in Long-Evans Rats.

    Science.gov (United States)

    Bardi, M; Kaufman, C; Franssen, C; Hyer, M M; Rzucidlo, A; Brown, M; Tschirhart, M; Lambert, K G

    2016-05-01

    Enriched environments are beneficial to neurobiological development; specifically, rodents exposed to complex, rather than standard laboratory, environments exhibit evidence of neuroplasticity and enhanced cognitive performance. In the present study, the nature of elements placed in the complex environment was investigated. Accordingly, rats (n = 8 per group) were housed either in a natural environment characterised by stimuli such as dirt and rocks, an artificial environment characterised by plastic toys and synthetic nesting materials, a natural/artificial environment characterised by a combination of artificial and natural stimuli or a laboratory standard environment characterised by no enrichment stimuli. Following exposure to emotional and cognitive behavioural tasks, including a cricket hunting task, a novel object preference task and a forced swim task, brains were processed for glial fibrillary acidic protein (GFAP)-, neuronal nuclei (NeuN)- and brain-derived neurotrophic factor (BDNF) immunoreactivity. Baseline and stress foecal samples were collected to assess corticosterone (CORT) and dehydroepiandrosterone (DHEA). Natural environment animals exhibited shorter diving latencies and increased diving frequencies in the second forced swimming task, along with higher DHEA/CORT ratios, and higher GFAP immunoreactivity in the hippocampus. The type of environmental enrichment did not influence levels of BDNF immunoreactivity in the CA1, CA3 and dentate gyrus of the hippocampus; however, natural environment animals exhibited higher levels of NeuN immunoreactivity in the retrosplenial cortex, an area involved in spatial memory and other cognitive functions. These results suggest that, in addition to enhancing behavioural and endocrinological variables associated with resilience, exposure to natural stimuli might alter plasticity in brain areas associated with cortical processing and learning. © 2016 British Society for Neuroendocrinology.

  7. Acute and Subchronic Toxicity of Inhaled Toluene in Male Long-Evans Rats: Oxidative Stress Markers in Brain

    Science.gov (United States)

    The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute an...

  8. Acute and Subchronic Toxicity of Inhaled Toluene in Male Long-Evans Rats: Oxidative Stress Markers in Brain

    Science.gov (United States)

    The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute an...

  9. THE TRANSCRIPTIONAL PROFILE OF THE KIDNEY IN TSC2 HETEROZYGOUS MUTANT LONG EVANS (EKER) RATS COMPARED TO WILD-TYPE

    Science.gov (United States)

    Hereditary renal cell carcinoma (RCC) in Eker rats results from an inherited insertional mutation in the Tsc2 tumor suppressor gene and provides a valuable experimental model to characterize the function of the Tsc2 gene product, tuberin in vivo. The Tsc2 mutation predisposes the...

  10. 3-päevane üliõpilastöö - "Roheline lava" = 3-day student project - "Green stage"

    Index Scriptorium Estoniae

    2008-01-01

    Tutvustatakse Tallinna Tehnikakõrgkooli Arhitektuuri õppetooli õpitoa "Intelligentsed konstruktsioonid" raames 4. kursuse arhitektuuri ja ehituse eriala üliõpilaste kavandatud 11 "Rohelise lava" lahendust Tallinna lauluväljaku maa-alale. Üliõpilasi juhendasid Irina Raud ja Stefan Polonyi (Saksamaa)

  11. The democratic experience in divided societies : the Baltic states in comparative perspective / Geoffrey Evans, Christine S Lipsmeyer

    Index Scriptorium Estoniae

    Evans, Geoffrey

    2001-01-01

    Artiklis võrreldakse vähemusrahvuste rahulolu demokratiseerimisprotsessiga ning osalemist demokraatlikes protsessides kolmes Balti riigis ning kümnes Ida-Euroopa riigis 1990. aastail. Tabelid. Lisa: The surveys

  12. Dorsal lateral geniculate substructure in the Long-Evans rat: A cholera toxin B-subunit study

    Directory of Open Access Journals (Sweden)

    Claire B. Discenza

    2012-09-01

    Full Text Available The pigmented rat is an increasingly important model in visual neuroscience research, yet the lamination of retinal projections in the dLGN has not been examined in sufficient detail. From previous studies it was known that most of the rat dLGN receives monocular input from the contralateral eye, with a small island receiving predominantly ipsilateral projections. Here we revisit the question using cholera toxin B subunit (CTB, a tracer that efficiently fills retinal terminals after intra-ocular injection. We imaged retinal termini throughout the dLGN at 0.5 um resolution and traced areas of ipsilateral and contralateral terminals to obtain a high resolution 3D reconstruction of the projection pattern. Retinal termini in the dLGN are well segregated by eye of origin, as expected. We find, however, that the ipsilateral projections form multiple discrete projection zones in three dimensions, not the single island previously described. It remains to be determined whether these subdomains represent distinct functional sublaminae, as is the case in other mammals.

  13. Freuds kvindelige bipersoner

    DEFF Research Database (Denmark)

    Lund, Jacob

    2014-01-01

    Anm. af Groce Smilevski: "Freuds søster" og Karen Mack og Jennifer Kaufman: "Freuds elskerinde"......Anm. af Groce Smilevski: "Freuds søster" og Karen Mack og Jennifer Kaufman: "Freuds elskerinde"...

  14. Effects of Prenatal Exposure to a Low Dose Atrazine Metabolite Mixture on pubertal timing and prostrate Development of Male Long Evans Rats.

    Science.gov (United States)

    The present study examines the postnatal reproductive development of male rats following prenatal exposure to an atrazine metabolite mixture (AMM) consisting of the herbicide atrazine and its environmental metabolites diaminochlorotriazine, hydroxyatrazine, deethylatrazine, and d...

  15. BRAIN CHOLINESTERASE INHIBITION PRODUCED BY PROPOXUR AND DEPRESSION OF THE PHOTIC AFTER DISCHARGE OF FLASH EVOKED POTENTIALS IN LONG EVANS RATS.

    Science.gov (United States)

    Propoxur is a widely used N-methyl carbamate pesticide that acts by inhibiting cholinesterases (ChE), which may lead to cholinergic toxicity. Flash evoked potentials (FEPs) are a neurophysiological response following stimulation of the visual system with flashes of light. They ar...

  16. Occupy Education: Living and Learning Sustainability. By Tina Lynn Evans, Peter Lang Publishing, 2012; 356 Pages. Price: $39.95, ISBN 978-1-4331-1966-8

    Directory of Open Access Journals (Sweden)

    Shu-Kun Lin

    2013-02-01

    Full Text Available Occupy Education is motivated by the sustainability crisis and energized by the drive for social justice that inspired the Occupy movement. Situated within the struggle for sustainability taking place amid looming resource shortages, climate change, economic instability, and ecological breakdown, the book is a timely contribution to community education and action. It opens a whole realm of integrated theory to educators and sustainability activists-and demonstrates how that theory can be moved into practice. Occupy Education is an excellent text for courses in sustainability studies, social philosophy, globalization, social justice, food system praxis, sustainability education, political economy, and environmental studies.

  17. Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials.

    Science.gov (United States)

    Morimoto, Bruce

    2010-07-01

    The Second Annual marcus evens Drug Development for Neurodegenerative Diseases Conference, held in Boston, included topics covering new therapeutic developments in the field of neurodegenerative diseases. This conference report highlights selected presentations on biomarkers for neurodegenerative diseases; novel approaches to therapy for neurodegenerative disorders, including targeting PKCepsilon in Alzheimer's disease, small-molecule therapeutics for neurogenesis, neureglins to promote neurorecovery, and updates on several investigational drugs; and progress in neurodegenerative disease research, including measuring microtubule dynamics in Parkinson's disease and drug delivery to the brain. Investigational drugs discussed include NNI-251 (NeuroNascent Inc), neuregulins including glial growth factor 2 (Acorda Therapeutics Inc), AL-108 (Allon Therapeutics Inc) and EVP-0962 (EnVivo Pharmaceuticals Inc).

  18. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young long-evans rats

    Science.gov (United States)

    Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol)is a chlorinated phenolic antibacterial compound used in consumer products. Structural similarity of triclosan to thyroid hormones, in vitro activation ofthe human pregnane X receptor (PXR) and induction of hepatic Phase I enzymes...

  19. Mental Health Nursing Made Incredibly Easy! Evans Debbie Allen Helen Mental Health Nursing Made Incredibly Easy! 544pp Lippincott Williams & Wilkins 9781901831108 1901831108 [Formula: see text].

    Science.gov (United States)

    2010-08-11

    This is an informative read for any nurse or student training in the mental health field. It includes more than 70 conditions from anxiety to schizophrenia, as well as the range of treatment options. It also looks at nursing concepts in mental health and subjects such as communication, consent, multidisciplinary care, advocacy and scope of practice. There are expert tips on patient care, research, cultural considerations and the latest news in psychopharmacology.

  20. Protocol for isolation of Moniliophthora roreri (Cif and Par Evans et al. from cacao fruits cv. `National' in the Ecuadorian Amazonia

    Directory of Open Access Journals (Sweden)

    Karina Carrera-Sánchez

    2014-07-01

    Full Text Available Moniliophthora roreri is a pathogen of cocoa (Theobroma cacao L. that causes high economic losses in Ecuador. This paper is intended to present a protocol for the isolation of the pathogen from cocoa fruits cv. `National', showing signs and symptoms of disease. The fruits were collected on farms of Napo (Ecuador. By wet chamber, it was able to induce profusely, sporulation on the surface of selected lesions. The isolations were performed from conidia directly located on the surface of fruits with brown powdery appearance. Isolation procedures and suggested of possible applications are presented.   Key words: amazonia, basidiomycetes, fungi, moniliasis, Theobroma cacao L.