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Sample records for kaposiform hemangioendothelioma khe

  1. Atypically presenting kaposiform hemangioendothelioma of the knee: ultrasound findings.

    Science.gov (United States)

    Erdem Toslak, Iclal; Stegman, Matthew; Reiter, Michael P; Barkan, Güliz A; Borys, Dariusz; Lim-Dunham, Jennifer E

    2018-04-10

    Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of early childhood and infancy. Kasabach-Merritt phenomenon, a common complication of KHE, is characterized by life-threatening thrombocytopenia, hemolytic anemia, and consumption coagulopathy. There may be atypical cases that do not present with Kasabach-Merritt phenomenon and do have atypical imaging findings. Knowledge of atypical imaging features may assist radiologists in identifying KHE. In this report, we present a 4-year-old case of KHE with atypical ultrasound findings.

  2. Imaging findings of Kaposiform Hemangioendothelioma in children

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    Ryu, Young Jin [Department of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of); Department of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Choi, Young Hun, E-mail: iater@snu.ac.kr [Department of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of); Department of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Cheon, Jung-Eun; Kim, Woo Sun; Kim, In-One [Department of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of); Department of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul (Korea, Republic of); Park, Ji Eun [Department of Radiology, Graduate School, Kyung Hee University, Seoul (Korea, Republic of); Kim, Yu Jin [Department of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of)

    2017-01-15

    Purpose: Kaposiform hemangioendothelioma (KHE) is a rare, aggressive vascular tumor that typically occurs during infancy or early childhood. Though several case reports have discussed the imaging findings of KHE, larger comprehensive studies are lacking. The purpose of this study was to evaluate the imaging findings of KHE in children. Materials and methods: A total of twelve cases of pathologically proven KHE were collected by searching our institution’s pathology database for children diagnosed between January 2004 and April 2016 (6 male, 6 female; median age: 3 months; age range 7 days − 18 years). CT (n = 7) and MRI (n = 9) findings were retrospectively evaluated. The location, morphology, enhancement, and growth pattern were analyzed. Results: KHEs involved various locations: superficial or deep soft tissue of the extremities (n = 4); abdomen (n = 3; 2 cases, pancreas; 1 case, small bowel), neck and mediastinum (n = 1); chest wall, diaphragm, and pericardium (n = 1); abdominal wall (n = 1); and head (IAC, CP angle) (n = 2). Eight of 10 cases (80%) with CT/MR findings were locally invasive and involved two or more adjacent organs. Three cases presented as well-defined solid masses, and seven were associated with infiltrative lesions of the surrounding areas with (n = 4) or without definite solid regions (n = 3). In nine patients with MRI, all KHEs were heterogeneous and hyperintense to muscles on T2-weighted images (T2WI), while four KHEs consisted of some regions that were nearly isointense to muscle. Eight of the 10 cases with imaging exhibited heterogeneous intense enhancement, while only one demonstrated mild enhancement. Signal voids (n = 2), engorged vessels (n = 1), calcification (n = 3), hemorrhage (n = 1), or bone changes (n = 4) were infrequently observed. Four patients (33%) had Kasabach-Merritt phenomenon, and recurrence was observed in two cases. Conclusion: KHEs occurred in various locations, affected mostly infants, and generally exhibited

  3. Recurrent multifocal cutaneous Kaposiform hemangioendothelioma: A rare vascular tumor of infancy and childhood

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    Bhagyalakshmi Atla

    2016-01-01

    Full Text Available Kaposiform hemangioendothelioma (KHE is a locally aggressive vascular tumor of childhood although cases occurring in adulthood are also described. The features overlap with juvenile capillary hemangioma and Kaposi sarcoma. We report a rare case of recurrent, multifocal (nose and chin cutaneous KHE initially occurring in a 3-year-old female child, uncomplicated by Kasabach–Merritt syndrome. Recurrences occurred over the next 6 years and resulted in complete distortion of the nose, requiring plastic repair.

  4. Recurrent multifocal cutaneous Kaposiform hemangioendothelioma: A rare vascular tumor of infancy and childhood.

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    Atla, Bhagyalakshmi; Sudhakar, P V; Rao, Nagarjun; Prasad, Uma

    2016-01-01

    Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor of childhood although cases occurring in adulthood are also described. The features overlap with juvenile capillary hemangioma and Kaposi sarcoma. We report a rare case of recurrent, multifocal (nose and chin) cutaneous KHE initially occurring in a 3-year-old female child, uncomplicated by Kasabach-Merritt syndrome. Recurrences occurred over the next 6 years and resulted in complete distortion of the nose, requiring plastic repair.

  5. Kaposiform hemangioendothelioma of the spleen in an adult: an initial case report.

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    Yu, Lu; Yang, Shou Jing

    2011-12-01

    Kaposiform hemangioendothelioma (KHE) is a rare locally aggressive vascular neoplasm characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma. KHE occurs mainly in newborns and infants and presents most commonly in the skin, deep soft tissue, and bone. We report a case of KHE in a 36-year-old female who presented with a spleen mass and underwent splenectomy. Macroscopic examination revealed a large, dark-red, firm mass in the spleen. Histologically, the tumor consisted of irregular, infiltrating nodules of densely packed spindle-shaped tumor cells closely associated with small slit-like and sieve-like blood vessels, which were separated with hyalinized hypocellular fibrous stroma. Immunohistochemically, both spindle and epithelioid cells were positive for CD34, CD31, and vimentin, but negative for EMA, cytokeratin, CD21, CD35, CD1a, and S-100 protein. The well-formed capillaries and mature vessels but not spindle tumor cell showed reactivity for factor VIII- related antigen. Alpha-Smooth muscle actin was detected in pericytes surrounding small round or slit-like capillaries. The final histologic diagnosis was KHE. Follow-up 6 month after operation revealed no sign of recurrence or metastasis.To the best of our knowledge, this is the first report of KHE arising in the spleen.

  6. The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon.

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    Vivas-Colmenares, Grecia V; Ramirez-Villar, Gema L; Bernabeu-Wittel, Jose; Matute de Cardenas, Jose A; Fernandez-Pineda, Israel

    2015-01-01

    Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (TA). Typical features also include low fibrinogen and elevated D-dimers. It is well known that KMP is not caused by infantile hemangiomas. Management of vascular tumors complicated by KMP is challenging, and it is common for referral centers to receive patients in critical medical condition after multimodality treatment failure of vascular anomalies. Our aim is to communicate the importance of early diagnosis and treatment of KHE associated with KMP. A full-term male newborn with KHE complicated by KMP is reported. Treatment with vincristine, aspirin and ticlopidine normalized the coagulation parameters within one week, requiring a total of six doses of vincristine, seven months of ticlopidine and 17 months of aspirin. Early diagnosis and treatment of KHE complicated by KMP may allow the administration of fewer doses of vincristine and avoid the use of corticosteroids.

  7. Treating kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon by intralesional injection of absolute ethanol.

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    Shen, Weimin; Cui, Jie; Chen, Jianbin; Zou, Jijun; Xiaoying, Zhang

    2014-11-01

    Kasabach-Merritt phenomenon (KMP) is characterized by thrombocytopenia, microangiopathic hemolytic anemia, consumptive coagulopathy, and an enlarging vascular lesion. It is a rare and life-threatening disease of vascular tumor. The purpose of this study was to assess the effectiveness of absolute ethanol in the treatment of KMP. We treated 8 pediatric patients with KMP by using absolute ethanol injections, whose cases failed previously when applied steroid therapy. We reviewed the clinical and laboratory data of these 8 cases at Nanjing Children's Hospital in China. Eight pediatric patients (5 female and 3 male) showed tumor regression after treatments. Core needle biopsy had been performed on the 8 patients, and the results included 7 kaposiform hemangioendotheliomas and one tufted angioma. All patients had an increase in platelet count. All coagulopathies were corrected. Complications included one patient with flush on face, one patient with needle scars, and one patient with a small area of local tissue necrosis. Absolute ethanol therapy presents a safe option in the treatment of KMP. Treatment-associated complications seemed to be reversible and acceptable by severity levels. Direct intralesional injection of absolute ethanol provides a simple and reliable alternative treatment for KMP among infants and may be used as the second-line therapy.

  8. Imaging features of kaposiform lymphangiomatosis

    International Nuclear Information System (INIS)

    Goyal, Pradeep; Alomari, Ahmad I.; Shaikh, Raja; Chaudry, Gulraiz; Kozakewich, Harry P.; Perez-Atayde, Antonio R.; Trenor, Cameron C.; Fishman, Steven J.; Greene, Arin K.

    2016-01-01

    Kaposiform lymphangiomatosis is a rare, aggressive lymphatic disorder. The imaging and presenting features of kaposiform lymphangiomatosis can overlap with those of central conducting lymphatic anomaly and generalized lymphatic anomaly. To analyze the imaging findings of kaposiform lymphangiomatosis disorder and highlight features most suggestive of this diagnosis. We retrospectively identified and characterized 20 children and young adults with histopathological diagnosis of kaposiform lymphangiomatosis and radiologic imaging referred to the vascular anomalies center between 1995 and 2015. The median age at onset was 6.5 years (range 3 months to 27 years). The most common presenting features were respiratory compromise (dyspnea, cough, chest pain; 55.5%), swelling/mass (25%), bleeding (15%) and fracture (5%). The thoracic cavity was involved in all patients; all patients had mediastinal involvement followed by lung parenchymal disease (90%) and pleural (85%) and pericardial (50%) effusions. The most common extra-thoracic sites of disease were the retroperitoneum (80%), bone (60%), abdominal viscera (55%) and muscles (45%). There was characteristic enhancing and infiltrative soft-tissue thickening in the mediastinum and retroperitoneum extending along the lymphatic distribution. Kaposiform lymphangiomatosis has overlapping imaging features with central conducting lymphatic anomaly and generalized lymphatic anomaly. Presence of mediastinal or retroperitoneal enhancing and infiltrative soft-tissue disease along the lymphatic distribution, hemorrhagic effusions and moderate thrombocytopenia (50-100,000/μl) should favor diagnosis of kaposiform lymphangiomatosis. (orig.)

  9. Epitheloid hemangioendothelioma of urinary bladder

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    Narmada P Gupta

    2008-01-01

    Full Text Available Epitheloid hemangioendothelioma is an uncommon vascular neoplasm and has an unpredictable clinical behavior. It is characterized by round or spindle-shaped endothelial cells with cytoplasmic vacuolation. Most often, epitheloid hemangioendothelioma arise from the soft tissues of the upper and lower extremities and it has borderline malignant potential. We describe the first reported case of epitheloid hemangioendothelioma in the urinary bladder, which was treated by transurethral resection. The diagnosis was confirmed by immunohistochemistry.

  10. Infantile hemangioendothelioma of liver

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    Goo, Jin Mo; Kim, Woo Sun; Kim, In One; Yoon, Chong Hyun; Yeon, Kyung Mo; Choi, Choong Gon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1993-05-15

    Radiologic findings of hemangioendothelioma of the liver were retrospectively analyzed in twelve infants. The radiological examinations included were sonography in 12 patients, computed tomography (CT) in six, magnetic resonance (MR) imaging in five, and angiography in two. Four patients were diagnosed pathologically, two by angiography, five by follow-up sonography, and one by clinical presentation with sonography. The common radiologic findings of the hemangioendothelioma were well circumscribed heterogeneous echogenic mass (75%) on sonography, peripheral massive enhancement (67%) on CT, bright high signal intensity on T2-weighted MR image (100%), and homogenous or peripheral enhancement (75%) on Gd-DTPA enhanced T1-weighted MR image. Dilated proximal aorta and enlarged draining hepatic veins on angiography and other studies were also important findings. The follow-up sonography demonstrated the involution of lesions with some calcification in four patients and complete resolution in one. The authors believe that these findings in an infant under the age of 6 months strongly suggest the diagnosis of hemangioendothelioma of the liver, and follow-up sonography should be done.

  11. Epithelioid hemangioendothelioma of the liver

    International Nuclear Information System (INIS)

    Ashraf, S.; Ashraf, H.M.; Mamoon, N.; Luqman, M.L.

    2007-01-01

    Epithelioid hemangioendothelioma is an intermediate grade malignant neoplasm of vascular origin. The tumor involves the liver and lungs, but other organs are affected too. The key to the diagnosis is identification of cells of endothelial origin containing Factor VIII R antigen. Surgical resection of isolated lesions is the treatment of choice; with unpredictable results reported for chemotherapy, radiotherapy, and resection of multiple lesions. The prognosis is very variable, and ranges from few months to more than 25 years. (author)

  12. [Epithelioid hemangioendothelioma: an uncommon liver tumor].

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    Pareja, Eugenia; Cortés, Miriam; Rayon, Miguel; Moya, Angel; Mir, Jose

    2010-01-01

    We report the case of a female patient who was referred to our unit because of a solid liver tumor, suggestive of metastasis. After biopsy, the patient was diagnosed with epithelioid hemangioendothelioma of the liver. Epithelioid hemangioendothelioma is a rare entity with an unpredictable, potentially fatal, clinical course and outcome. Due to its rarity, this entity should be considered when a solitary hepatic lesion is detected and should be included in the differential diagnosis with liver metastases. We highlight the infrequency of this tumor, its presentation as a solitary hepatic lesion and the indication of surgical treatment. We describe the clinical and pathological characteristics of epithelioid hemangioendothelioma of the liver and report a new case of this entity. The distinct therapeutic options are discussed. Copyright 2010 Elsevier España, S.L. All rights reserved.

  13. Hemangioendothelioma of the skull: A case report

    International Nuclear Information System (INIS)

    Gana, R.; Fatemi, N.; Sghiar, J.; Maaqili, R.; Bellakhdar, F.

    2008-01-01

    Hemangioendothelioma is a rare vascular tumour of endothelial cell origin. It may involve bone or soft tissues and can behave like a benign or malignant tumour. A 54-year-old man presented with localized swelling over the parietal and occipital bones. He was neurologically intact. Radiographic images showed an expansible osteolytic lesion in the parietal-occipital bones. The patient was treated by wide surgical resection. This report contributes to the scarce literature on these tumours in the skull

  14. Cellular hemangioma and angioblastoma of the spine, originally classified as hemangioendothelioma. A confusing diagnosis

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    Been, H. D.; Fidler, M. W.; Bras, J.

    1994-01-01

    The authors report two cases of vascular tumors of the spine, classified originally as benign and malignant hemangioendothelioma, and after revision, as cellular hemangioma and angioblastomatosis, respectively. Problems in interpretation of the confusing term hemangioendothelioma and treatment

  15. Epithelioid Hemangioendothelioma: Update on Diagnosis and Treatment.

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    Rosenberg, Ari; Agulnik, Mark

    2018-03-15

    Epithelioid hemangioendothelioma (EHE) is an extremely rare sarcoma, as such it can pose a clinical dilemma based solely on its rarity. Also, the spectrum of disease varies greatly between an indolent disease and aggressive disease with widespread metastases. In our clinical practice, the primary focus has been to get a handle on the aggressive nature of the disease, which will then dictate how urgently one needs to treat the patient. Pathological review with immunohistochemistry and molecular characterization is paramount. Our treatment strategy is watch-and-wait versus active therapy on clinical trial or based on results of prior clinical trials. There is evidence to support the use of chemotherapeutics and targeted therapies specifically focusing on anti-angiogenesis. The current landscape of oncology with the emergence and excitement of immunotherapy could also translate in a role for immunotherapy in this disease. While rare, there is certainly no reason that research and trials for patients with EHE should not remain on utmost importance for those of us who specialize in the treatment of sarcomas.

  16. CT and MR imaging characteristics of infantile hepatic hemangioendothelioma

    International Nuclear Information System (INIS)

    Feng Shiting; Chan Tao; Ching, A.S.C.; Sun Canhui; Guo Huanyi; Fan Miao; Meng Quanfei; Li Ziping

    2010-01-01

    Aim: This study aims to analyze computed tomography (CT) and magnetic resonance (MR) imaging features of infantile hepatic hemangioendotheliomas before and after treatment. Materials and methods: CT and MR examinations of seven infants with biopsy proven hepatic hemangioendotheliomas were retrospectively analyzed. The distribution, number, size, imaging appearance, enhancement pattern and post-treatment changes of the tumors were evaluated. Results: A total of 153 hepatic hemangioendotheliomas were detected on CT (111) and MR (42) imaging. In six infants, 109/111 (98.2%) tumors were hypodense and 2/111 (1.8%) lesions contained calcification on unenhanced CT. On MR imaging, all 42 lesions in one infant were heterogeneously T1-hypointense and T2-hyperintense compared to the normal liver parenchyma. Contrast-enhanced CT and MRI showed peripheral rim (51.6%), uniform (48.4%), fibrillary (33.3%), and nodular (28.8%) contrast enhancement in the hepatic arterial phase. Homogeneous (100%), rim (98.2%) and mixed enhancement patterns were noted in tumors 2.0 cm and 1.0-2.0 cm in diameter respectively in the hepatic arterial phase. In three patients who underwent steroid therapy, follow-up CT examination demonstrated tumor size reduction and increased intra-tumoral calcification in two patients. Conclusion: Infantile hepatic hemangioendotheliomas show some typical imaging features and size-dependent pattern of contrast enhancement on CT and MR imaging, which allow accurate imaging diagnosis and post-treatment evaluation.

  17. Low-Grade Uterine Epithelioid Hemangioendothelioma Presented as a Submucosal Leiomyoma during Labor

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    Anastasios V. Koutsopoulos

    2013-01-01

    Full Text Available With the exception of leiomyomas, soft tissue tumors of the uterine corpus are not common. This is particularly true for vascular neoplasms, with the epithelioid hemangioendothelioma being a curiosity; not more than twenty-two cases of malignant hemangioendotheliomas have been reported in the literature so far, all of which were high-grade hemangioendotheliomas (hemangiosarcomas. We present herewith a unique case of low-grade epithelioid hemangioendothelioma of the uterus in a pregnant woman aged 29 years. The clinical, histological, and immunohistochemical characteristics of this entity, together with its differential diagnosis, are discussed.

  18. Emission profiles of K-He exciplexes in cold helium gas

    International Nuclear Information System (INIS)

    Allard, N F

    2012-01-01

    Emission spectra of exciplexes composed of a light alkali atom in the first excited state and 4 He atoms have been observed in cryogenic gas in the spectral range from the atomic D lines to 6300 cm −1 . A unified semi-classical theory of line broadening has been used to determine the total profile from the center to the far wings of emission profiles of potassium perturbed by helium at low temperatures and high He density. The agreement of the theoretical peak positions of K*He n exciplexes compared to the experimental determinations is fairly good. Such comparisons provide a critical test of the calculated molecular potentials and the relevance of the theoretical approach which has been used.

  19. Multifocal and metastatic hepatic hemangioendothelioma: case report and literature review

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    Torres, Lucas Rios; Galvao Filho, Mario Melo [Hospital Sao Luiz, Sao Paulo, SP (Brazil); Timbo, Luciana Satiro; Verrastro, Carlos Gustavo Yuji; D' Ippolito, Giuseppe, E-mail: giuseppe_dr@uol.com.br [Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP (Brazil). Escola Paulista de Medicina; Ribeiro, Cristiane Maria de Freitas [Laboratorio Diagnostica, Sao Paulo, SP (Brazil)

    2014-05-15

    Epithelioid hemangioendothelioma is a rare neoplasm of vascular origin whose involvement of organs such as lung, spleen, bone, breast and liver has already been reported. The clinical signs and the prognosis of this tumor are quite variable. From the present case report, the authors have sought to contribute with literature data, by reviewing clinical and radiological features which may be useful to include such a condition in the differential diagnosis of liver lesions. (author)

  20. Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation

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    We report a unique case of a 3-mo-old female with consumptive hypothyroidism and liver hemangioendothelioma who required pharmacological doses of thyroid hormones and was cured following liver transplantation. Liver hemangioendotheliomas are capable of producing an excess of the thyroid hormone inac...

  1. Multifocal epithelioid hemangioendothelioma of the phalanges of the hand

    International Nuclear Information System (INIS)

    Bruegel, Melanie; Waldt, Simone; Woertler, Klaus; Rummeny, Ernst J.; Weirich, Gregor

    2006-01-01

    Epithelioid hemangioendothelioma (EH) of bone is a rare vascular neoplasm characterized by epithelioid endothelial cells and a variable biologic behaviour. The principal sites of occurrence of this osteolytic tumor are the lower extremity and the axial skeleton. Approximately half of the cases present with multifocal disease. The latter feature can be helpful in suggesting the diagnosis of a vascular tumor; on the other hand, it strengthens the need for a skeletal survey or whole-body MRI/CT. We report on the clinical, histologic and radiologic features - including CT and MRI findings - of EH in a case of multifocal disease of the phalanges of the hand, a very uncommon anatomic site of affliction. (orig.)

  2. Epithelioid hemangioendothelioma of the spine. Report of two cases.

    LENUS (Irish Health Repository)

    Aquilina, Kristian

    2012-02-03

    Epithelioid hemangioendothelioma (EH) is a rare tumor of vascular origin. The authors describe two cases of spinal EH, one involving the T-10 vertebra and the second involving the upper cervical spine. In the first case the patient underwent resection of the tumor; this case represents the longest reported follow-up period for spinal EH. In the second case, extensive involvement of C-2, C-3, and C-4 as well as encasement of both vertebral arteries precluded safe tumor resection, and posterior occipitocervical stabilization was performed. The patient subsequently died of metastatic disease. The findings in these two cases underscore the difficulty in predicting the clinical behavior of spinal EH based solely on histological and clinical features as well as the uncertainty of the roles of surgery, chemotherapy, and radiotherapy in the oncological management of a spinal tumor for which clinical data are very limited.

  3. Epithelioid hemangioendothelioma – A rare pulmonary tumor

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    Sandra Saleiro

    2008-05-01

    Full Text Available The authors report a case of a rare pulmonary neoplasm – epithelioid hemangioendothelioma, in a 39 year-old woman, asymptomatic until December 2003, when she developed pleuritic and right-sided chest pain. The patient presented a previous chest radiograph, performed 13 years before, which showed multiple small bilateral pulmonary nodules attributed to tuberculous sequelae. The definitive histological diagnosis was made by lung biopsy through thoracotomy. The patient developed a clinical and imagiological worsening and then therapy with interferon α-2a was started. Even with imagiological stability of pulmonary lesions the patient remained symptomatic and died nine months after the diagnosis had been established.The authors emphasise the rarity of this type of pulmonary neoplasm and discuss its clinical presentation, histological features, treatment and prognosis. Resumo: Os autores descrevem um caso de uma neoplasia pulmonar rara – hemangioendotelioma epitelióide – numa doente do sexo feminino, de 39 anos, assintomática até Dezembro de 2003, altura em que apresentou toracalgia direita de características pleuríticas. A doente era portadora de uma radiografia torácica antiga, efectuada há 13 anos, que revelava múltiplos pequenos nódulos pulmonares bilaterais, atribuídos a sequelas de tuberculose pulmonar. O diagnóstico histológico definitivo foi efectuado através de biópsia pulmonar por toracotomia. Dado a doente ter apresentado agravamento clínico e imagiológico foi iniciada terapêutica com interferão α-2a. Apesar da estabilidade imagiológica das lesões pulmonares, a doente manteve-se sintomática e faleceu nove meses depois do diagnóstico ter sido estabelecido.Os autores realçam a raridade deste tipo de neoplasia pulmonar e discutem a sua apresentação clínica, características histológicas, tratamento e prognóstico. Key-words: Epithelioid

  4. Pulmonary Epithelioid Hemangioendothelioma in a Patient with Crohn’s Disease

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    Nanda Ramchandar

    2015-01-01

    Full Text Available Pulmonary epithelioid hemangioendothelioma (PEH is a rare neoplasm, largely unresponsive to chemotherapeutic medications, and with varied prognosis. Imaging on computerized tomography may demonstrate perivascular nodules, but diagnosis is ultimately made on biopsy with immunohistochemical analysis. Here we describe a case of PEH in a 14-year-old male with Crohn’s disease, which, to our knowledge, has not previously been described in the literature.

  5. Solitary hepatic infantile hemangioendothelioma: dynamic gadolinium-enhanced MR imaging findings

    International Nuclear Information System (INIS)

    Mortele, Koenraad J.; Vanzieleghem, Bart; Mortele, Bart; Benoit, Yves; Ros, Pablo R.

    2002-01-01

    We report the MRI findings of a solitary hepatic infantile hemangioendothelioma (IHE) diagnosed in a 14-day-old girl. To the best of our knowledge, only one report has illustrated the dynamic gadolinium-enhanced MR imaging features of IHE previously. Compounding the rarity of presentation as a solitary mass, the gadolinium-enhanced MRI appearance in our case is unique, because the IHE showed an early rim-like pseudocapsular enhancement followed by progressive fill-in of the lesion on delayed imaging. (orig.)

  6. Retiform hemangioendothelioma over forehead: A rare tumor treated with chemoradiation and a review of literature

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    Anup Sunil Tamhankar

    2015-01-01

    Full Text Available Retiform hemangioendothelioma (RH is low grade tumor of skin and subcutaneous tissue. It needs to be differentiated from angiosarcoma as RH has excellent prognosis. It is usually seen in young adults on extremities. Sometimes it may mimic benign conditions and can delay treatment. Surgery has been mainstay of its treatment with or without adjuvant radiation. We present first case of RH on face. This is only second case being treated with definitive chemoradiation. So it′s important to distinguish RH from angiosarcoma due to treatment implications as well.

  7. Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine

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    Matthew P. Soape

    2015-01-01

    Full Text Available Hepatic epithelioid hemangioendothelioma (HEH is extremely rare, occurring in 1 to 2 per 100,000, with chemotherapy options not well defined. Our case involved a 49-year-old female who had hepatic masses and metastasis to the lungs with a liver biopsy revealing HEH. After developing a rash from sorafenib, thalidomide was started with the progression of disease stabilized. Resection is only an option in 10% of the cases; therefore, chemotherapy is the only line of treatment. Newer chemotherapy alternatives are targeting angiogenesis via the vascular endothelial growth factor. Thalidomide was first used as an antiemetic, but, sadly, soon linked to phocomelia birth defects. Given the mechanism of action against angiogenesis, thalidomide has a valid role in vascular tumors. In conclusion, the use of thalidomide as chemotherapy is novel and promising, especially in the setting of a rare vascular liver tumor such as HEH.

  8. Primary pleural epithelioid hemangioendothelioma (EHE)--two cases and review of the literature.

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    Lazarus, Angeline; Fuhrer, Gregory; Malekiani, Christina; McKay, Sean; Thurber, John

    2011-01-01

    We present two cases with symptoms of progressively worsening cough, dyspnea, decreased exercise tolerance and right-sided back pain in the first case and upper respiratory symptoms characterized by cough and a low grade fever in the second case. Report of two cases. The initial chest X-ray in both the cases showed pleural effusion. Further imaging with computed tomography of the chest confirmed the effusion in both cases. Thoracentesis was done in both of them revealed an exudative effusion that did not reveal any infection or malignancy. Both cases underwent surgical biopsy and the diagnosis of primary pleural epithelioid hemangioendothelioma was made. Both the cases had progressive clinical deterioration despite chemotherapy with Taxol and Bevacizumab in one case and carboplatin, etoposide, and bevacizumab, in the second case. Both developed metastatic disease to lungs and died. Published 2010. This article is a US Government work and is in the public domain in the USA.

  9. Multifocal Epithelioid Hemangioendothelioma Derived from the Spine Region: Case Report and Literature Review

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    G. Kerry

    2012-02-01

    Full Text Available Background: Epithelioid hemangioendothelioma (EHE is a rare vascular tumor with malignant biological behavior. It arises from endothelial cells, usually within soft tissues, and can occur in almost all locations. Case Report: We report a unique case of a 25-year-old man who presented with sudden attacks of severe back pain followed by acute non-traumatic paraplegia. Emergency diagnostics revealed a pathologic fracture of the T7 vertebra with tumor tissue invasion of the spinal canal. Furthermore, multifocal metastases were found. Results: To achieve en bloc resection, interdisciplinary surgical approaches were indicated. Despite multimodal therapy concepts, including radiotherapy and chemotherapy as well as endovascular embolization, the patient died within 8 weeks. Conclusion: Prognosis of EHE is unpredictable and mainly determined by its location. The lesions are potentially aggressive; therefore, en bloc resection should be attempted whenever possible. However, as shown in the literature, only 15% of patients are suitable for total resection.

  10. 18-F-FDG PET-CT in Monitoring of Chemotherapeutic Effect in a Case of Metastatic Hepatic Epithelioid Hemangioendothelioma.

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    Shamim, Shamim Ahmed; Tripathy, Sarthak; Mukherjee, Anirban; Bal, Chandrasekhar; Roy, Shambo Guha

    2017-01-01

    Hepatic epithelioid hemangioendothelioma is a rare variant of mesenchymal tumor. Surgical resection or partial hepatectomy is the treatment of choice in the case of localized disease. However, in metastatic cases, chemotherapeutic drugs targeting the tyrosine kinase are being used. We hereby present 18-F-fludeoxyglucose positron emission tomography-computed tomography findings in a case of a 35-year old woman with metastatic HEHE showing significant response to Sorafenib therapy after 6 months.

  11. Epithelioid hemangioendothelioma of the spine treated with RapidArc volumetric-modulated radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Guy, Jean-Baptiste; Trone, Jane-Chloé [Department of Radiotherapy, Institut de Cancérologie de la Loire, St Priest en Jarez (France); Chargari, Cyrus [Department of Radiation Oncology, HIA du Val de Grâce, Paris (France); Falk, Alexander Tuan [Department of Radiation Oncology, Centre Antoine Lacassagne, Nice (France); Khodri, Mustapha [Department of Physics, Institut de Cancérologie de la Loire, St Priest en Jarez (France); Magné, Nicolas, E-mail: nicolas.magne@icloire.fr [Department of Radiotherapy, Institut de Cancérologie de la Loire, St Priest en Jarez (France)

    2014-10-01

    Radiotherapy for epithelioid hemangioendothelioma (EHE) using volumetric intensity-modulated arc radiotherapy (VMAT). A 48-year-old woman was referred for curative irradiation of a vertebral EHE after failure of surgery. A comparison between VMAT and conventional conformal tridimensional (3D) dosimetry was performed and potential advantage of VMAT for sparing critical organs from irradiation's side effects was discussed. The total delivered dose on the planning target volume was 54 Gy in 27 fractions. The patient was finally treated with VMAT. The tolerance was excellent. There was no acute toxicity, including no increase in pain. With a follow-up of 18 months, no delayed toxicity was reported. The clinical response consisted of a decrease in the dorsal pain. The D{sub max} for the spinal cord was reduced from 55 Gy (3D-radiotherapy [RT]) (which would be an unacceptable dose to the spine because of the risk of myelopathy) to 42.8 Gy (VMAT), which remains below the recommended dose threshold (45 Gy). The dose delivered to 20% of organ volume (D{sub 20}) was reduced from 47 Gy (3D-RT) to 3 Gy (VMAT) for the spinal cord. The study shows that VMAT allows the delivery of curative treatment for vertebral EHEs because of critical organ sparing.

  12. Diffuse Hepatic Epithelioid Hemangioendothelioma Developed in a Patient with Hepatitis C Cirrhosis

    Directory of Open Access Journals (Sweden)

    Pedro W. Baron

    2014-01-01

    Full Text Available Hepatic epithelioid hemangioendothelioma (HEHE is an infrequent vascular tumor of endothelial origin that primarily occurs in women in the mid-fifth decade of life without underlying chronic liver disease or cirrhosis. Liver transplant should be the first-line of therapy in patients with large or diffuse unresectable tumors even in the presence of metastatic disease due to the favorable long-term outcome. We report the case of a 48-year-old female who complained of abdominal pain and weight loss. She has a history of cirrhosis secondary to chronic hepatitis C (HCV and was treated with interferon and ribavirin with sustained virological response. Her work-up revealed multiple confluent infiltrating bilobar liver masses diagnosed as HEHE. She underwent a successful liver transplant without evidence of recurrent HCV infection. She developed cervical spine (C4-C6 HEHE metastases 4 years after transplant. She underwent surgical resection and local radiotherapy after resection with good clinical response. To the best of our knowledge, this is the first report of HEHE that developed in a patient with HCV cirrhosis successfully treated with antiviral therapy before transplant and liver transplant with good allograft function without evidence of recurrent liver tumor or HCV infection but developed metastases to the cervical spine 4 years after transplant.

  13. A case of a resectable single hepatic epithelioid hemangioendothelioma with characteristic imaging by ADC map.

    Science.gov (United States)

    Okano, Hiroshi; Nakajima, Hideki; Tochio, Tomomasa; Suga, Daisuke; Kumazawa, Hiroaki; Isono, Yoshiaki; Tanaka, Hiroki; Matsusaki, Shimpei; Sase, Tomohiro; Saito, Tomonori; Mukai, Katsumi; Nishimura, Akira; Matsushima, Nobuyoshi; Baba, Youichirou; Murata, Tetsuya; Hamada, Takashi; Taoka, Hiroki

    2015-12-01

    A 47-year-old woman with a single-nodule hepatic tumor was referred to our hospital. She had no symptoms. The tumor was located at the surface of the right lobe of the liver; it showed peripheral low signal intensity on a magnetic resonance imaging apparent diffusion coefficient (ADC) map, and an influx of blood flow into the peripheral area of the tumor at the early vascular phase on perflubutane microbubble (Sonazoid(®)) contrast-enhanced (CE) ultrasonography. Since we suspected a malignant tumor, the patient underwent surgical resection. The hepatic tumor was resected curatively. Pathological examination revealed that the tumor was composed of epithelioid cells with an epithelioid structure and/or cord-like structure. Immunohistochemical staining was positive for cluster of differentiation 34 and factor VIII-related antigen. Based on the above, a final diagnosis of hepatic epithelioid hemangioendothelioma (EHE) was made. Hepatic EHE is a rare hepatic tumor: only a few cases of hepatic EHE with curative resection have been reported. We were unable to reach a diagnosis of hepatic EHE by imaging studies; however, an ADC map was useful in showing the malignant potential of the tumor, and CE ultrasonography was useful in revealing the peripheral blood flow of the tumor. When an unusual hepatic mass is encountered, hepatic EHE should be kept in mind, and the mass should be inspected with more than one imaging modality, including an ADC map, in the process of differential diagnosis.

  14. Hepatic Epithelioid Hemangioendothelioma Presenting as an Enlarging Vascular Lesion within the Spleen

    Directory of Open Access Journals (Sweden)

    Juliet A. Emamaullee

    2018-01-01

    Full Text Available Epithelioid hemangioendothelioma (EHE is a rare vascular neoplasm with variable malignant potential that most often presents within the liver. Many patients present with bilobar or extrahepatic disease, and the current treatment paradigm involves liver transplantation, with favorable long term results. Up to 25% of patients are diagnosed incidentally following imaging for other indications, and confirmation of diagnosis requires histologic analysis, as there are no classical imaging features to distinguish hepatic EHE (HEHE from other solid hepatic lesions. Here we describe a case of microscopic HEHE that was diagnosed following splenectomy for an enlarging vascular tumor within the spleen. Due to the unexpected diagnosis of EHE within the spleen and coexisting but stable appearing liver hemangiomata, a left hepatic lobectomy was performed. Explant histology revealed benign hemangiomata and diffuse, microscopic HEHE. The patient ultimately underwent liver transplantation. HEHE can be a challenging diagnosis, and this case emphasizes that any enlarging vascular lesion, even within the spleen, should prompt a high index of suspicion for HEHE in the setting of known hemangiomata.

  15. Unresectable Retiform Hemangioendothelioma Treated with External Beam Radiation Therapy and Chemotherapy: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Alina Z. Hirsh

    2010-01-01

    Full Text Available Retiform hemangioendothelioma (RH is an infrequently encountered vascular neoplasm of intermediate or borderline malignancy. Treatment of RH is controversial. We present a case of a 44-year-old Asian male presenting with an unresectable RH of the pelvis. The patient was treated with concurrent low-dose Cisplatin and External beam Radiation (4140cGy in 180cGy per fraction. This is the first report of a clinical complete response and a long-term local control of this rare tumor. This has significant clinical implication, since it gives the first evidence of treatment of this rare tumor using concurrent low-dose chemotherapy and radiation.

  16. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor

    Directory of Open Access Journals (Sweden)

    Angela Sardaro

    2014-10-01

    Full Text Available Epithelioid hemangioendothelioma is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma. The etiology is still a dilemma. Studies about suggestive hypothesis are ongoing. Most of the times it affects lung, liver and bones, although this kind of tumor may involve the head and neck area, breast, lymph nodes, mediastinum, brain and meninges, the spine, skin, abdomen and many other sites. Because of its heterogeneous presentation, as it represents less than 1% of all the vascular tumors, it is often misdiagnosed and not suitably treated, leading to a poor prognosis in some cases. Over 50-76% of the patients are asymptomatic. A small number of them complains respiratory symptoms. Bone metastases might cause pathological fractures or spine compression, if they arise in vertebrae. Imaging is necessary to determine morphological data, the involvement of surrounding tissues, and potentially the cleavage plan. It is important to recognize the expression of vascular markers (Fli-1 and CD31 are endothelial-specific markers, and the microscopic evidence of vascular differentiation to make a correct diagnosis, as many pulmonary diseases show multiple nodular lesions. Because of its rarity, there is no standard for treatment. We focused on radiotherapy as a good therapeutic option: despite the poor prognosis, evidence is in favor of radiotherapy which offers local pain control with good tolerance and better quality of life at least at a one-year follow-up in most of cases. Further studies are needed to establish the standard radiation dose to be used for locoregional control of such a complex and extremely rare disease.

  17. Epithelioid hemangioendothelioma of the liver with metastatic coeliac lymph nodes in an 11-year-old boy

    International Nuclear Information System (INIS)

    Ines, David da; Petitcolin, Virginie; Garcier, Jean-Marc; Joubert-Zakeyh, Juliette; Demeocq, Francois

    2010-01-01

    Epithelioid hemangioendothelioma of the liver is a very rare vascular tumour in children with intermediate malignant potential. We present a case in which the typical imaging appearances of coalescent peripheral hepatic masses with capsular retraction contributed to the diagnosis. A positron emission tomography-CT (PET-CT) procedure was performed in staging the disease with a strong suspicion of coeliac nodal involvement confirmed after laparotomy and histological analysis. Our case is unique because of the rarity of the disease, the young age of the child, and proven nodal metastases at initial diagnosis. The use of PET-CT allows better staging at initial diagnosis and thus better management with improved follow-up in these patients. (orig.)

  18. Pleural epitheliod hemangioendothelioma: What started as a liver fluke and ended up being almost mistaken for malignant mesothelioma

    Directory of Open Access Journals (Sweden)

    Omer H Jamy

    2015-01-01

    Full Text Available Epitheliod hemangioendothelioma (EHE is a rare tumor of vascular origin. The pleural variant has only been reported around 20 times in English literature. It commonly occurs in older men and carries a poor prognosis with average survival lasting from a few weeks to months. Pleural EHE (PEHE can be a diagnostic challenge due to its rarity as well as similarities to other pleural and vascular tumors. There is currently no standard treatment for EHE. Due to the rarity of this disease, reaching a final diagnosis is challenging. It′s clinical, radiological, and pathological resemblance to malignant mesothelioma can cause a delay in diagnosis. Special stains such as CD31, CD34, and factor VIII related antigen can help differentiate between the two. Ordering appropriate stains in a timely manner can help avoid misdiagnosing PEHE.

  19. Epithelioid hemangioendothelioma and multiple thoraco-lumbar lateral meningoceles: two rare pathological entities in a patient with NF-1

    International Nuclear Information System (INIS)

    Reis, C.; Carneiro, E.; Fonseca, J.; Salgado, A.; Pereira, P.; Vaz, R.; Pinto, R.; Capelinha, A.F.; Lopes, J.M.

    2005-01-01

    Epithelioid hemangioendothelioma (EHE) is a rare vascular soft-tissue tumour of intermediate malignancy. Neurofibromatosis type I (NF-1) is a genetic syndrome associated with soft tissue sarcoma and higher risk of developing neoplasia. Lateral meningoceles are uncommon entities, being mostly associated with NF-1. We report a case of a 31-year-old woman, with NF-1 and past history of right thalamic/peduncular astrocytoma WHO grade II, admitted to the Neurosurgery Department in December 2003 due to severe low back pain, irradiating to the left leg without a radicular pattern. Thoraco-lumbar magnetic resonance imaging (MRI) showed a large left posterior paravertebral expansive lesion, bilateral and multiple thoraco-lumbar lateral meningoceles and dural ectasias with scalloping of the vertebral bodies. Biopsy of the paravertebral mass lesion disclosed EHE. We present this case because of the novel association between NF-1 and EHE, and the unusual aggressiveness of the neoplasia. Additionally, we highlight the co-existence of bilateral and multiple lateral meningoceles. (orig.)

  20. Retiform hemangioendothelioma developed on the site of an earlier cystic lymphangioma in a six-year-old girl.

    Science.gov (United States)

    Albertini, Anne-Fore; Brousse, Nicole; Bodemer, Christine; Calonje, Eduardo; Fraitag, Sylvie

    2011-10-01

    Retiform hemangioendothelioma (RH) is a rare low-grade malignancy angiosarcoma, with a high rate of local recurrence and a low metastatic risk. A 6 year-old girl with a large cervical cystic lymphangioma diagnosed by ultrasound and Doppler ultrasound, which showed a large multiloculated anechoic cyst with no flow. The lymphangioma was treated with injections of Picibanil (OK-432). The tumor regressed, but after a year, she developed a poorly limited infiltrated plaque spreading out regularly over her chest, back, and shoulder. The biopsy showed a poorly limited dermal and subcutaneous vascular proliferation composed of elongated arborising vessels lined with ovoid endothelial cells in a hobnail pattern. In addition, the deep part of the lesion showed typical features of a papillary intralymphatic angioendothelioma pattern (PILA) or Dabska tumor. The endothelial cells strongly expressed podoplanin (D2-40). A diagnosis of RH with focal areas of PILA was reached. The girl died 8 months after surgery of hypovolemic shock in a context of diffuse lymphangiomatosis with pulmonary localization. To our knowledge, RH has hardly ever been described in children. This entity exhibits a continuum with the PILA, sharing not only morphological and immunohistochemical similarities but also its ability to develop in a context of a vascular anomaly, particularly a lymphangioma. The role of Picibanil in the development of this tumor can be discussed.

  1. Spindle Cell Hemangioendothelioma of the Temporal Muscle Resected with Zygomatic Osteotomy: A Case Report of an Unusual Intramuscular Lesion Mimicking Sarcoma

    Directory of Open Access Journals (Sweden)

    Tomohiro Minagawa

    2011-01-01

    Full Text Available Spindle cell hemangioendothelioma (SCH was originally described by Weiss and Enzinger (1986 as a low-grade angiosarcoma resembling both cavernous hemangioma and Kaposi's sarcoma. Recent studies suggest that SCH is a benign neoplasm or reactive lesion accompanying a congenital or acquired vascular malformation. Most SCHs present as one or more nodules affecting the dermis or subcutis of the distal extremities. Few reports describe SCH of the head and neck region; even fewer note intramuscular SCH. Here, we describe a case of SCH involving the temporal muscle mimicking soft tissue sarcoma, who had a successful surgical treatment with a coronal approach and zygomatic osteotomy.

  2. Vincristine: A new treatment option for Kasabach-Merritt Syndrome

    Directory of Open Access Journals (Sweden)

    Shalini Avasthi

    2011-07-01

    Full Text Available Kasabach-Merritt syndrome (KMS is characterized by a rapidly enlarging hemangioma, thrombocytopenia, microangiopathic hemolytic anemia and consumption coagulopathy as a result of platelet and red blood cell trapping and activation of clotting system within the vasculature of hemangioma. This syndrome is shown to be associated with kaposiform hemangioendotheliomas or tufted hemangioma.

  3. Imaging evaluation of fetal vascular anomalies

    International Nuclear Information System (INIS)

    Calvo-Garcia, Maria A.; Kline-Fath, Beth M.; Koch, Bernadette L.; Laor, Tal; Adams, Denise M.; Gupta, Anita; Lim, Foong-Yen

    2015-01-01

    Vascular anomalies can be detected in utero and should be considered in the setting of solid, mixed or cystic lesions in the fetus. Evaluation of the gray-scale and color Doppler US and MRI characteristics can guide diagnosis. We present a case-based pictorial essay to illustrate the prenatal imaging characteristics in 11 pregnancies with vascular malformations (5 lymphatic malformations, 2 Klippel-Trenaunay syndrome, 1 venous-lymphatic malformation, 1 Parkes-Weber syndrome) and vascular tumors (1 congenital hemangioma, 1 kaposiform hemangioendothelioma). Concordance between prenatal and postnatal diagnoses is analyzed, with further discussion regarding potential pitfalls in identification. (orig.)

  4. Imaging evaluation of fetal vascular anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Calvo-Garcia, Maria A.; Kline-Fath, Beth M.; Koch, Bernadette L.; Laor, Tal [MLC 5031 Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Adams, Denise M. [Cincinnati Children' s Hospital Medical Center, Department of Pediatrics and Hemangioma and Vascular Malformation Center, Cincinnati, OH (United States); Gupta, Anita [Cincinnati Children' s Hospital Medical Center, Department of Pathology, Cincinnati, OH (United States); Lim, Foong-Yen [Cincinnati Children' s Hospital Medical Center, Pediatric Surgery and Fetal Center of Cincinnati, Cincinnati, OH (United States)

    2015-08-15

    Vascular anomalies can be detected in utero and should be considered in the setting of solid, mixed or cystic lesions in the fetus. Evaluation of the gray-scale and color Doppler US and MRI characteristics can guide diagnosis. We present a case-based pictorial essay to illustrate the prenatal imaging characteristics in 11 pregnancies with vascular malformations (5 lymphatic malformations, 2 Klippel-Trenaunay syndrome, 1 venous-lymphatic malformation, 1 Parkes-Weber syndrome) and vascular tumors (1 congenital hemangioma, 1 kaposiform hemangioendothelioma). Concordance between prenatal and postnatal diagnoses is analyzed, with further discussion regarding potential pitfalls in identification. (orig.)

  5. Victualing Victory: Logistics from Lake George to KHE SANH, 1755-1968

    Science.gov (United States)

    2016-06-01

    German Double Track Lines) (HATCHED - Narrow Gauge Trench Rails) (Figure 2.1 Reprinted with permission from Chris Baker “The German Retreat to the...The First World War: Germany and Austria-Hungary, 1914-1918, 331. 157 Chris Baker, "Extract From the War Diary of 118 Siege Battery RGA," http...combustion engine to develop landing craft to move troops from transport ships to the beaches. The famed Higgins boat was the accomplice to this

  6. Biodegradation of organ chlorine pesticides in contaminated soil collected from Yen Tap, Cam Khe, Phu Tho

    International Nuclear Information System (INIS)

    Nguyen Thuy Binh; Nguyen Van Toan; Pham Thi Thai; Dinh Thi Thu Hang

    2007-01-01

    Biodegradation of POPs contaminant in soil collected from Phu Tho province and Nghe An province had carried out. The process comprises treating soil, which contains anaerobic and aerobic microbes capable of transforming lindane and DDT into harmless material and being under anaerobic and aerobic steps. Significant biodegradation of POPs contaminants occurred in there tests. But some of toxic organic compounds remained. (author)

  7. Metastatic Angiosarcoma with Kasabach-Merritt Syndrome Responsive to Gemcitabine and Vinorelbine after Failure of Liposomal Doxorubicin and Paclitaxel: A Case Report

    Directory of Open Access Journals (Sweden)

    William L. Read

    2016-03-01

    Full Text Available Kasabach-Merritt syndrome (KMS describes a consumptive coagulopathy associated with certain vascular tumors. It is thought that platelets are destroyed as they circulate through the aberrant endothelial surfaces associated with these tumors. Most published literature describes infants with kaposiform hemangioendothelioma, but a similar syndrome can complicate angiosarcoma in adults. This report describes a man with metastatic angiosarcoma arising in the scalp in whom disease progression was complicated by profound thrombocytopenia consistent with KMS. His disease and associated KMS had progressed previously through paclitaxel and then through liposomal doxorubicin. It did not respond to paclitaxel and bevacizumab, but responded almost completely to chemotherapy with gemcitabine and vinorelbine. Six months later, progression through ongoing chemotherapy then responded to chemotherapy with cyclophosphamide and sirolimus.

  8. The Tet Offensive and the Battle of Khe Sahn as a Watershed of the Vietnam War: Michael Herr's Dispatches

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Moreira da Rocha

    2013-08-01

    Full Text Available ABSTRACT: The literature of war, independently of genre, tends to record the causes of the conflict, which are generally political and economic. But, it also tends to appoint a kind of aesthetics of reception, in other words, how the conflict is felt and registered by the experiences of the individual, whether soldier, writer, journalist or common reader. In Dispatches, the fantasies of the grunts, the allusions to the theory of dominoes, the necessity to win the hearts and minds of the Vietnamese people, and the role of the press are condensed in this remarkable non-fictional narrative.

  9. Excitation processes in slow K+--He, Ne, Ar, H2, N2 and Na+--He collisions

    International Nuclear Information System (INIS)

    Kikiani, B.I.; Gochitashvili, M.R.; Kvizhinadze, R.V.; Ankudinov, V.A.

    1984-01-01

    Quasimolecular features of excitation processes in K + --He, Ne, Ar, H 2 , N 2 and Na + --He collisions were investigated by measuring the cross sections for the emission of the resonance lines of potassium (lambda = 766.5 and 769.9 nm), sodium (lambda = 589 and 589.6 nm), and helium (lambda = 584 nm) atoms at ion energies in the range 0.5--10 keV. In Na + --He collisions, the resonance-line excitation functions obtained for sodium and helium atoms exhibit oscillations that are in antiphase and are due to phase interference between the quasimolecular states of the system of colliding particles. Experimental data on K + --Ar collisions are interpreted in terms of schematic correlation diagrams for molecular orbitals. The excitation mechanisms for K + --N 2 and K + --Ar have beenfound to be similar, and this leads to the conclusion that the quasimolecular model used for the ion-atom case is also valid for the ion-molecule case. It is shown that the excitation of the 4p-state of the potassium atom in the K + --Ar case is due to a Landau-Zener type of interaction in the region of the quasicrossing of (KAr) + terms. Analysis of the excitation of this state in K + --N 2 collisions also shows that the capture of an electron into the excited 4p-state of the potassium atom is due to a nonadiabatic transition in the region of quasicrossing of energy terms of the same symmetry

  10. Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy

    Directory of Open Access Journals (Sweden)

    Worawut Choeyprasert

    2014-01-01

    Full Text Available Kasabach-Merritt phenomenon (KMP is relatively rare in childhood and adolescents with high mortality rate because of its hemorrhagic complications and unresponsiveness to treatments such as corticosteroids, vincristine, intravascular embolization, and/or surgery. Propranolol, a β-adrenergic receptor blocker, has a promising efficacy against vascular tumors such as infantile hemangiomas. But limited and variable data has been reported regarding the role of propranolol in treatment of KMP. We herein reported the successful treatment of mild pediatric KMP with propranolol monotherapy in a case of a five-week-old child with kaposiform hemangioendothelioma with successful treatment of both clinical and hematologic responses. After eight months of follow-up, patient still had stable cutaneous lesion while receiving propranolol monotherapy. Regular hematologic monitoring was done in order to detect any late relapse of the disease. Six months after discontinuation of propranolol, patient has still remained free of hematologic relapse, and primary cutaneous lesion has become a pale pink, 1 cm sized skin lesion.

  11. Hemangioendotelioma epitelióide do pulmão: Raridade, dificuldades diagnósticas e terapêutica Pulmonary epithelioid hemangioendothelioma: Rarity, diagnosis and treatment difficulties

    Directory of Open Access Journals (Sweden)

    Telma Lopes

    2009-11-01

    Full Text Available Os autores apresentam um caso de hemangioendotelioma epitelioide (HEE primário do pulmão num doente de 51 anos, sexo masculino, que iniciou queixas de tosse seca, seguida de sintomas constitucionais e dispneia. Apôs realização de alguns exames complementares de diagnostico, que incluiram biopsia cirúrgica, foi considerada a hipótese de tuberculose pulmonar e iniciou antibacilares, que manteve durante três semanas. Por agravamento clínico e imagiologico, foi feita revisão do caso e estudo imunoistoquimico dos tecidos pulmonares biopsados e concluiu-se estar perante um HEE de alto grau/angiossarcoma do pulmão. Iniciou quimioterapia com carboplatina, etoposido e bevacizumab, com ligeira melhoria. Faleceu sete meses após o aparecimento dos primeiros sintomas e sete semanas apos o diagnostico definitivo. Os autores pretendem realçar a raridade desta neoplasia pulmonar, a importância da suspeição clínica e as dificuldades no diagnostico e tratamento, e salientar os potenciais benefícios da utilização de um fármaco antiangiogenico.The authors report a case of a primary pulmonary epithelioid haemangioendothelioma (EHE in a 51 year-old man, a mechanic, who complained of a dry cough followed by constitutional symptoms and dyspnoea. Patient underwent a series of diagnostic exams including surgical biopsy and pulmonary tuberculosis was diagnosed. He was prescribed tuberculosis drugs for three weeks. Following clinical and imagiology deterioration, the case was reviewed by pathologists who concluded the pulmonary biopsy revealed an intermediate/high grade pulmonary EHE/angiosarcoma. The patient underwent three cycles of chemotherapy with carboplatin, etoposide and bevacizumab with no complications. He died seven months after onset of symptoms and seven weeks after definitive diagnosis. The authors wish to highlight the rarity of this pulmonary neoplasm and the importance of clinical suspicion, and the diagnosis and treatment difficulties in addition to the potential benefits of antiangiogenic drugs.

  12. Angiolymphoid Hyperplasia with Eosinophilia of Orbit in Young Male

    African Journals Online (AJOL)

    occur in pregnancy and also following trauma in some cases.[2] ALHE .... malignant vascular proliferations including pyogenic granuloma, epithelioid hemangioendothelioma and ... middle‑aged women, presenting as a subcutaneous nodule ...

  13. A New Swarm Intelligence Approach for Clustering Based on Krill Herd with Elitism Strategy

    Directory of Open Access Journals (Sweden)

    Zhi-Yong Li

    2015-10-01

    Full Text Available As one of the most popular and well-recognized clustering methods, fuzzy C-means (FCM clustering algorithm is the basis of other fuzzy clustering analysis methods in theory and application respects. However, FCM algorithm is essentially a local search optimization algorithm. Therefore, sometimes, it may fail to find the global optimum. For the purpose of getting over the disadvantages of FCM algorithm, a new version of the krill herd (KH algorithm with elitism strategy, called KHE, is proposed to solve the clustering problem. Elitism tragedy has a strong ability of preventing the krill population from degrading. In addition, the well-selected parameters are used in the KHE method instead of originating from nature. Through an array of simulation experiments, the results show that the KHE is indeed a good choice for solving general benchmark problems and fuzzy clustering analyses.

  14. Fast fashion Que Ri : irreverência, imitação e inovação

    OpenAIRE

    Giongo, Marina Anderle; Szabluk, Daniela; Linden, Júlio Carlos de Souza van der

    2015-01-01

    Este artigo apresenta uma análise das estratégias utilizadas pela Budha Khe Rhi, uma empresa brasileira de moda. A abordagem de pesquisa adotada foi o estudo de caso único, baseado em análise documental, observação de campo e entrevistas com o diretor de marketing da empresa. A Budha Khe Rhi desenvolveu-se como uma marca reconhecida e associada a estilo de vida e experiências que os jovens valorizam. Hoje em dia, após a expansão por meio de abertura de franquias, a empresa está em transição p...

  15. Tactical Airlift and Direct Support: The Keys to USAF Relevance in Modern Counterinsurgency and Their Struggle Against Air Force Culture

    Science.gov (United States)

    2011-04-01

    and his Viet Minh government resisted, and an insurgency erupted in 1946. When Mao Tse -tung conquered China, the Viet Minh had the sanctuary they...South Vietnam. This road accessed both Laos and the Ho Chi Minh Trail.70 It was decided that the U.S. Marines would hold Khe Sanh, although the

  16. Determination of PCDD/Fs in breast milk of women living in the vicinities of Da Nang Agent Orange hot spot (Vietnam) and estimation of the infant's daily intake.

    Science.gov (United States)

    Hue, N T M; Nam, V D; Thuong, N V; Huyen, N T; Phuong, N T H; Hung, N X; Tuan, N H; Son, L K; Minh, N H

    2014-09-01

    Seventeen toxic congeners of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were determined in breast milks using the high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS) method. Twenty seven breast milk samples were collected from primiparae who have lived over 5 years in wards namely Chinh Gian, An Khe, Khue Trung, and Hoa Thuan Tay which are located near the Da Nang Agent Orange hot spot (the AO/Dioxin hot spot). The samples were then analyzed for PCDD/F residues in order to assess the human exposure to dioxins from the AO/Dioxin hot spot, especially health risk to the breast-fed infants. The average TEQ levels in the four studied cohorts ranged from 8.1 to 26 pg/g lipid, with the highest level up to 51 pg TEQ/g lipid found in the An Khe ward. The TEQ level was correlated with geographical position and ranking in the order of Khue Trung, Hoa Thuan Tay, Chinh Gian and An Khe. The mean estimated PCDD/Fs infant's daily intake in the cohort of Khue Trung, Hoa Thuan Tay, Chinh Gian and An Khe was about 41, 122, 124, and 134 pg TEQ/kg bw/day, respectively, which are much higher than the tolerable daily intake proposed by the World Health Organization (4 pg TEQ/kg bw/day). Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Emission spectra of alkali-metal (K,Na,Li)-He exciplexes in cold helium gas

    International Nuclear Information System (INIS)

    Enomoto, K.; Hirano, K.; Kumakura, M.; Takahashi, Y.; Yabuzaki, T.

    2004-01-01

    We have observed emission spectra of excimers and exciplexes composed of a light alkali-metal atom in the first excited state and 4 He atoms [K*He n (n=1-6), Na * He n (n=1-4), and Li * He n (n=1,2)] in cryogenic He gas (the temperature 2 K -1 . Differently from exciplexes with heavier alkali-metal atoms, the spectra for the different number of He atoms were well separated, so that their assignment could be made experimentally. Comparing with the spectra of K * He n , we found that the infrared emission spectrum of the K atom excited in liquid He was from K*He 6 . To confirm the assignment, we have also carried out ab initio calculation of adiabatic potential curves and peak positions of the emission spectra of the exciplexes

  18. Toxic Hazards Research Unit - 1988

    Science.gov (United States)

    1989-07-01

    13 APPENDIX 1 DRAIZEa SCALE FOR SCALING OCULAR LESIONS Parameter Score 1. Cornea A Opacity degree of density (area most taken for reading) No opacity...microscopic hepatocytomegaly as the principal manifestations of CTFE-induced hepatotoxicity The electron microscopic examination demonstrated...hemangioma (hemangioendothelioma), chronic portal hepatitis, chronic oviduct inflammation, chronic ovary inflammation, chronic vegetative endocarditis

  19. Childhood Vascular Tumors Treatment (PDQ®)—Health Professional Version

    Science.gov (United States)

    Vascular tumors in children are a spectrum of diseases that includes infantile, congenital, spindle cell and epithelioid hemangiomas, as well as angiofibromas, hemangioendotheliomas, and angiosarcomas. Get detailed information about the many types of vascular tumors including clinical presentation, diagnosis, prognosis and treatment in this summary for clinicians.

  20. Rao Quan Feasibility Study - Phase 1: Toxic Substances and Contamination (Final Report)

    Energy Technology Data Exchange (ETDEWEB)

    Berge, Dag; Knutzen, Jon

    1997-12-31

    Due to wartime activity in the Khe Sanh area, it was expected that damming of the river Rao Quan could wash out diffuse pollutants from the ground and from possible military dump sites. As discussed in this report, the rivers Rao Quan, Khe Nghi and Quang Tri contain relatively soft water. The buffer capacity against acidification is good. The sulphate concentration is low. The water will not be aggressive against concrete. The maximum particulate content in the wet season is low. The nutrient content of the rivers is relatively low. The phosphorus content correlated well with the turbidity, which indicates that the phosphorus is bound to particles. Khe Nghi has significantly higher nitrogen content than the other rivers, which may indicate some slight impact from animal husbandry. However, there was no eutrophication. The content of heavy metals is low and indicates no pollution from the military activities in the area. The water is well suited for irrigation. There was no indication from the analysed fish , the river sediments from Rao Quan or the top soil of the rice fields of any significant dioxin contamination. The content was similar to normal back ground levels caused by diffuse atmospheric fallout. The herbicide Agent Orange in 1962-1975 was applied mostly in the southernmost part of the country and contamination from it in the Quang Tri Province is not expected. 13 refs., 4 figs., 4 tabs.

  1. Stewart-Bluefarb acroangiodermatitis in a case of Parkes-Weber syndrome

    Directory of Open Access Journals (Sweden)

    Deepti H Ghia

    2014-01-01

    Full Text Available Stewart-Bluefarb acroangiodermatitis is the occurrence of pseudo-kaposiform changes with an underlying arterio-venous malformation. Parkes-Weber syndrome is a triad of arterio-venous malformation with varicose veins with bony and soft-tissue hypertrophy involving the extremity. A 13 year-old-female presented with ulcerated growth with bleeding episodes on right leg since past four years. A reddish discoloration over right leg was noticed at four years of age which remained unchanged until nine years of age, after which it showed rapid increase in size along with disproportionate increase in length and girth of right lower limb. Examination revealed hyperpigmented soft verrucous plaque over the right lower one-third of leg, along with presence of ulcers and dilated tortuous veins in the right lower leg with thrill and bruit over the right popliteal and inguinal region. A differential diagnosis of verrucous hemangioma and arterio-venous malformation with pseudo-kaposiform change was considered. Skin biopsy showed multiple fenestrated capillaries with perivascular lymphocyte infiltrate suggestive of capillary malformations. X-ray showed osteolytic defect in right tibia. Duplex ultrasound and magnetic resonance imaging of right leg showed multiple fast flowing small and medium sized arterio-venous malformations of small to moderate size. Thus, on the basis of clinical and radiological features, we made a diagnosis of Stewart-Bluefarb type of acroangiodermatitis with Parkes-Weber syndrome. She was managed conservatively with compression stockings.

  2. Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma—a suitable treatment option: case report and review of anti-angiogenic treatment options

    International Nuclear Information System (INIS)

    Semenisty, Valeriya; Naroditsky, Inna; Keidar, Zohar; Bar-Sela, Gil

    2015-01-01

    Epithelioid hemangioendothelioma is a rare vascular tumor of borderline or low-grade malignancy. The lungs and liver are the two common primary organs affected. Metastatic disease was reported in more than 100 cases in the literature. However, no firm conclusions can be determined for recommended treatment options. The current case presents a patient with metastatic pulmonary epithelioid hemangioendothelioma to the cervical and mediastinal lymph nodes, lungs and liver that has been treated with pazopanib for more than two years with PET avid complete metabolic response in the mediastinum and lungs, and long-lasting stable disease. Target therapies that block VEGFR have a logical base in this rare malignancy. The current case is the first to report objective, long-lasting response to pazopanib

  3. Facial vascular malformations in children

    International Nuclear Information System (INIS)

    Brunelle, F.O.; Lallemand, D.; Chaumont, P.; Teillac, D.; Manach, Y.

    1988-01-01

    The authors present their experience with conventional and digital angiography of vascular malformations of the head and neck in children. 22 hemangioendotheliomas, 8 venous angiomas, and 3 arteriovenous fistula were studied. 22 patients were embolised. DSA offers many advantages during the diagnostic as well as during the therapeutic phase of angiography. Embolization appears to have a major role in treatment of such vascular malformations. (orig.)

  4. Bulky abdominal masses in pediatrics: iconographic essay; Massas abdominais volumosas em pediatria: ensaio iconografico

    Energy Technology Data Exchange (ETDEWEB)

    Reis, Fabiano; Faria, Andreia V.; Kluge, Patricia D.; Volpato, Ricardo G.; Santos, Sergio L.M. dos; Caserta, Nelson M.G. [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas]. E-mail: fabiano97@bol.com.br

    2005-04-15

    The ultrasound, computerized tomography and magnetic resonance findings of 19 patients with abdominal bulky masses diagnosed as hydronephrosis, Wilms' tumor, neuroblastoma, adrenal carcinoma, sarcoma, hemangioendothelioma, hepatoblastoma, mesenchymal hamartoma, hepatocellular carcinoma, choledochal cyst, splenic cyst, lymphoma, enteric cyst, teratoma, hydrometrocolpos and lipoma are presented. Imaging findings (including ultrasound, computerized tomography and magnetic resonance imaging) are important tools for the evaluation of abdominal masses in pediatric patients and can contribute to the diagnosis and evaluation of the extension of these diseases. (author)

  5. Modern warfare as a significant form of zoogeomorphic disturbance upon the landscape

    Science.gov (United States)

    Hupy, Joseph P.; Koehler, Thomas

    2012-07-01

    The damage exerted by warfare on the physical landscape is one, of many, anthropogenic impacts upon the environment. Bombturbation is a term that describes the impacts of explosive munitions upon the landscape. Bombturbation, like many other forms of zoogeomorphology, is a disruptive force, capable of moving large amounts of sediments, and denuding landscapes to the point where changes in micro and mesotopography have long-term implications. The long term implication of bombturbative actions depends on the type and duration of explosive device that rendered the disturbance, and the geographic context of the landscape disturbed; i.e. cultural and physical factors. Recovery from bombturbative activity, in the context of this research, is measured by vegetative regrowth and soil development in cratered disturbances. A comparison and contrast between the two battlefields of Verdun, France and Khe Sanh, Vietnam show that bombturbative actions have significantly altered the topography at each location, thus influencing surface runoff and processes of soil development. Principals of the Runge pedogenic model, or the energy of water moving through the soil profile, best explain how the varying climate and parent material at each location influence post disturbance soil development rates. Whereas the data collected at Verdun suggest that explosive munitions have put that landscape on diverging path of development, thus rendering it much different post-disturbance landscape, Khe Sanh displays much different recovery patterns. Preliminary research at Khe Sanh indicates that reforestation and soil development following disturbance are not so much influenced by bombturbative patterns as land use activities in the area of study.

  6. First record of a cave species of Euscorpiops Vachon from Viet Nam (Scorpiones, Euscorpiidae, Scorpiopinae).

    Science.gov (United States)

    Lourenço, Wilson R; Pham, Dinh-Sac

    2013-07-01

    Euscorpiops cavernicola sp. n., belonging to the family Euscorpiidae Laurie, is described on the basis of two male and two female specimens collected in the Hua Ma cave located in the Quang Khe commune, Ba Be district of Bac Kan province in Viet Nam. The new species presents most features exhibited by scorpions within the genus Euscorpiops, however it may represent the first discovered Scorpiopinae species exhibiting certain adaptations to cave life. Copyright © 2013 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  7. Differential cross sections of fine-structure transitions in K(4P)-He and -Ar collisions

    International Nuclear Information System (INIS)

    Mestdagh, J.M.; de Pujo, P.; Pascale, J.; Cuvellier, J.; Berlande, J.

    1987-01-01

    Differential cross sections for the transition K(4P/sub 3/2/→4P/sub 1/2/) induced by He and Ar have been studied both experimentally and theoretically. Calculations were performed using a full quantal close-coupling formalism. The angular distribution of the scattered atoms is measured by Doppler shift (ADDS method). The comparison with the theoretical calculations is performed on the basis of thorough kinematic analysis. In addition, the polarization effects corresponding to the experimental conditions are taken into account carefully. This allows one to test the accuracy of various interaction potentials available for the K-He and -Ar systems. The most interesting result concerns the K-He l-dependent pseudopotentials, which are found accurate to a sufficiently high level to allow good predictions of the observed differential cross-section patterns. In particular the positions and amplitudes of the cross-section oscillations at large center-of-mass scattering angles are well reproduced. The results for Ar show that the K-Ar potentials must be improved. Finally, taking the K(4P)-He fine-structure transition as an example, it has been shown how polarization effects may be used in ADDS measurements to obtain information on the dynamics of the collision process

  8. Binary and ternary recombination of D3+ ions at 80-130 K: Application of laser absorption spectroscopy

    Science.gov (United States)

    Dohnal, Petr; Hejduk, Michal; Rubovič, Peter; Varju, Jozef; Roučka, Štěpán; Plašil, Radek; Glosík, Juraj

    2012-11-01

    Recombination of D_3^+ ions with electrons at low temperatures (80-130 K) was studied using spectroscopic determination of D_3^+ ions density in afterglow plasmas. The use of cavity ring-down absorption spectroscopy enabled an in situ determination of the abundances of the ions in plasma and the translational and the rotational temperatures of the recombining ions. Two near infrared transitions at (5792.70 ± 0.01) cm-1 and at (5793.90 ± 0.01) cm-1 were used to probe the number densities of the lowest ortho state and of one higher lying rotational state of the vibrational ground state of D_3^+ ion. The results show that D_3^+ recombination with electrons consists of the binary and the third-body (helium) assisted process. The obtained binary recombination rate coefficients are in agreement with a recent theoretical prediction for electron-ion plasma in thermodynamic equilibrium with αbin(80 K) = (9.2 ± 2.0) × 10-8 cm3 s-1. The measured helium assisted ternary rate coefficients KHe are in agreement with our previously measured flowing afterglow data giving a value of KHe(80 K) = (1.2 ± 0.3) × 10-25 cm6 s-1.

  9. Binary and ternary recombination of D3+ ions at 80-130 K: application of laser absorption spectroscopy.

    Science.gov (United States)

    Dohnal, Petr; Hejduk, Michal; Rubovič, Peter; Varju, Jozef; Roučka, Štěpán; Plašil, Radek; Glosík, Juraj

    2012-11-21

    Recombination of D(3)(+) ions with electrons at low temperatures (80-130 K) was studied using spectroscopic determination of D(3)(+) ions density in afterglow plasmas. The use of cavity ring-down absorption spectroscopy enabled an in situ determination of the abundances of the ions in plasma and the translational and the rotational temperatures of the recombining ions. Two near infrared transitions at (5792.70 ± 0.01) cm(-1) and at (5793.90 ± 0.01) cm(-1) were used to probe the number densities of the lowest ortho state and of one higher lying rotational state of the vibrational ground state of D(3)(+) ion. The results show that D(3)(+) recombination with electrons consists of the binary and the third-body (helium) assisted process. The obtained binary recombination rate coefficients are in agreement with a recent theoretical prediction for electron-ion plasma in thermodynamic equilibrium with α(bin)(80 K) = (9.2 ± 2.0) × 10(-8) cm(3) s(-1). The measured helium assisted ternary rate coefficients K(He) are in agreement with our previously measured flowing afterglow data giving a value of K(He)(80 K) = (1.2 ± 0.3) × 10(-25) cm(6) s(-1).

  10. Geomechanical Assessments of Simultaneous Operation in the Case of Transition from Open Pit to Underground Mine in Vietnam

    Science.gov (United States)

    Niedbalski, Zbigniew; Nguyen, Phu Minh Vuong; Widzyk-Capehart, Eleonora

    2018-03-01

    Nowadays, for a number of reasons, many open pit mines are considering a transition from Open Pit (OP) to Underground (UG) to remain competitive. In OP-UG transition, UG operation is operated simultaneously with the OP operation for a certain period of time. Guidelines for the simultaneous operation of OP and UG are very difficult to establish, as there are very few case studies available. Yet, because of the OP-UG interactions; the operation has a higher safety, technical and management requirements than the OP or UG methods when considered separately. In Vietnam, Cao Son is one of many OP mines, which decided to change the operational system from OP to UG. Simultaneous operation started in 2015 and will be conducted until 2030 when the OP mine Cao Son ends its mining activities. In this paper, selected geomechanical considerations of the simultaneous operation are presented. A number of numerical modelling calculations using finitedifference software with code FLAC were carried out for calibration process, slope stability analysis and the OP-UG interaction analysis for the Cao Son - Khe Cham II-IV mine. Based on the results obtained from numerical modelling, the geomechanical assessments of simultaneous operation Cao Son - Khe Cham II-IV are discussed in this paper.

  11. Engineer exchanging project on coal mine technology field in fiscal 1999. International information exchanging project (the overseas workshop in Vietnam); 1999 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop (Vietnam)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Technical information exchange was performed with Vietnamese engineers related to coal mine technologies through the overseas workshop and the technical tour. At the same time, investigations were executed on the production technology levels and needs in Vietnam, and on possibilities of transfer of Japanese technologies. The 'Overseas workshop (Vietnam)' was held on September 28, 1999 with the 'trends and problems in coal production technologies' as the main theme. Lectures were given in the session related to coal production technologies by Vietnamese coal technology experts, each from VINACOAL and IMSAT, and by two Japanese coal technology experts. A comprehensive discussion was also executed, and items of technical information were exchanged on the coal production technologies. The number of persons actually participated in the workshop counted 58, with the proceedings presented by them distributed. The Mao Khe and Duong Huy coal mines in Quang Ninh Province were visited as the technical tour, whereas the coal mine sites were inspected and opinions were exchanged with the site engineers. Gas analysis was performed in the Mao Khe mine from the viewpoint of a gas control technology, and site investigation was carried out on lock bolts in the Duong Huy mine from the viewpoint of a roof control technology. (NEDO)

  12. Primary tumors of the patella. A review of 42 cases

    Energy Technology Data Exchange (ETDEWEB)

    Kransdorf, M.J. (Walter Reed Army Medical Center, Washington, DC (USA). Dept. of Radiology; University of the Health Sciences, Bethesda, MD (USA). Dept. of Radiology and Nuclear Medicine); Moser, R.P. Jr. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Radiologic Pathology; University of the Health Sciences, Bethesda, MD (USA). Dept. of Radiology and Nuclear Medicine); Vinh, T.N. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Orthopaedic Surgery); Aoki, J. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Radiologic Pathology); Callaghan, J.J. (Duke Univ., Durham, NC (USA). Dept. of Orthopaedic Surgery)

    1989-08-01

    This study reports 42 cases of histologically proven and radiographically correlated primary patellar tumors. Despite diverse histologic diagnoses, the radiographic appearanaces of benign as opposed to malignant patellar neoplasms are essentially indistinguishable. Although the literature suggests that giant cell tumor is the most frequent benign tumor of the patella, the most common benign neoplasm in this series is chondroblastoma (16 cases). Only four primary malignant lesions were encountered, three cases of lymphoma and one case of hemangioendothelioma. Since 38 (90%) of the 42 cases were benign, a benign etiology should be strongly favored, notwithstanding the radiographic appearance, whenever a primary patellar tumor is encountered. (orig.).

  13. Helium nanodroplets. Pump-probe ionization of alkali dopings and spin-echo scattering on undoped drops

    International Nuclear Information System (INIS)

    Droppelmann, G.

    2005-09-01

    In the framework of this thesis several aspects of the properties of helium nanodroplets and their dopings. The formation of the exciplexes RbHe and KHe on helium droplets was studied by means of pump-probe ionization in real time, whereby the main interest lied on the influence of the applied helium isotopes. The experiments with cesium atoms on the droplet surface aimed on the elucidation of the relaxation dynamics of the surface under regardment both of isotope and size effects. From the pump-probe measurements on the formation of the exciplex RbHe on helium nanodroplets performed in the framework of this thesis formation times of 8.5 ps for Rb 4 He and 11.6 ps for Rb 3 He resulted

  14. Helium nanodroplets. Pump-probe ionization of alkali dopings and spin-echo scattering on undoped drops; Helium-Nanotroepfchen. Pump-Probe-Ionisation von Alkalidotierungen und Spinechostreuung an undotierten Tropfen

    Energy Technology Data Exchange (ETDEWEB)

    Droppelmann, G.

    2005-09-15

    In the framework of this thesis several aspects of the properties of helium nanodroplets and their dopings. The formation of the exciplexes RbHe and KHe on helium droplets was studied by means of pump-probe ionization in real time, whereby the main interest lied on the influence of the applied helium isotopes. The experiments with cesium atoms on the droplet surface aimed on the elucidation of the relaxation dynamics of the surface under regardment both of isotope and size effects. From the pump-probe measurements on the formation of the exciplex RbHe on helium nanodroplets performed in the framework of this thesis formation times of 8.5 ps for Rb{sup 4}He and 11.6 ps for Rb{sup 3}He resulted.

  15. Spectroscopic features of the low-lying electronic states of some sodium-helium and potassium-helium van der Waals systems

    Science.gov (United States)

    Chattopadhyay, Anjan

    2011-08-01

    Configuration interaction studies on MHe and MHe2 (where M = Na, K) systems have revealed several interesting characteristics in the properties of their low-lying electronic states. Binding energy values of the 12Π1/2, 3/2 states in MHe systems are found to be lower than the values of 12Πu (1/2, 3/2) states in the He-M-He systems by a margin of more than 200 cm-1, indicating better exciplex stabilities of the latter systems. Excited states of the other variety of the linear MHe2 (M-He-He) systems are almost repulsive. The characteristic energy barrier of the first excited spin-orbit state of alkali metal-helium systems is found to be only 15 cm-1 in KHe and 19 cm-1 in He-K-He. For the Na*He and K*He exciplexes, predicted radiative lifetime values of 18.5 ns and 29.8 ns, respectively, are in excellent agreement with the experimental values. The red-tail portions of their emission bands are contributed by M*He2 exciplexes with relatively high radiative lifetimes. The repulsive excited state of 2Σ+1/2 (or 2Σ+g,1/2) symmetry in these van der Waals systems is likely to play an important role in the pumping of the blue side of the ns2S1/2 → np2P3/2 transition, which eventually may give rise to the np2P1/2 → ns2S1/2 lasing transition.

  16. Spectroscopic features of the low-lying electronic states of some sodium-helium and potassium-helium van der Waals systems

    Energy Technology Data Exchange (ETDEWEB)

    Chattopadhyay, Anjan, E-mail: anjan@bits-goa.ac.in, E-mail: anjan_chattopadhyay@yahoo.com [Department of Chemistry, Birla Institute of Technology and Science (BITS), Pilani -K.K. Birla Goa Campus, Goa, 403 726 (India)

    2011-08-28

    Configuration interaction studies on MHe and MHe{sub 2} (where M = Na, K) systems have revealed several interesting characteristics in the properties of their low-lying electronic states. Binding energy values of the 1{sup 2}{Pi}{sub 1/2,3/2} states in MHe systems are found to be lower than the values of 1{sup 2}{Pi}{sub u(1/2,3/2)} states in the He-M-He systems by a margin of more than 200 cm{sup -1}, indicating better exciplex stabilities of the latter systems. Excited states of the other variety of the linear MHe{sub 2} (M-He-He) systems are almost repulsive. The characteristic energy barrier of the first excited spin-orbit state of alkali metal-helium systems is found to be only 15 cm{sup -1} in KHe and 19 cm{sup -1} in He-K-He. For the Na*He and K*He exciplexes, predicted radiative lifetime values of 18.5 ns and 29.8 ns, respectively, are in excellent agreement with the experimental values. The red-tail portions of their emission bands are contributed by M*He{sub 2} exciplexes with relatively high radiative lifetimes. The repulsive excited state of {sup 2}{Sigma}{sup +}{sub 1/2} (or {sup 2}{Sigma}{sup +}{sub g,1/2}) symmetry in these van der Waals systems is likely to play an important role in the pumping of the blue side of the ns{sup 2}S{sub 1/2} {yields} np{sup 2}P{sub 3/2} transition, which eventually may give rise to the np{sup 2}P{sub 1/2} {yields} ns{sup 2}S{sub 1/2} lasing transition.

  17. Spectroscopic features of the low-lying electronic states of some sodium-helium and potassium-helium van der Waals systems

    International Nuclear Information System (INIS)

    Chattopadhyay, Anjan

    2011-01-01

    Configuration interaction studies on MHe and MHe 2 (where M = Na, K) systems have revealed several interesting characteristics in the properties of their low-lying electronic states. Binding energy values of the 1 2 Π 1/2,3/2 states in MHe systems are found to be lower than the values of 1 2 Π u(1/2,3/2) states in the He-M-He systems by a margin of more than 200 cm -1 , indicating better exciplex stabilities of the latter systems. Excited states of the other variety of the linear MHe 2 (M-He-He) systems are almost repulsive. The characteristic energy barrier of the first excited spin-orbit state of alkali metal-helium systems is found to be only 15 cm -1 in KHe and 19 cm -1 in He-K-He. For the Na*He and K*He exciplexes, predicted radiative lifetime values of 18.5 ns and 29.8 ns, respectively, are in excellent agreement with the experimental values. The red-tail portions of their emission bands are contributed by M*He 2 exciplexes with relatively high radiative lifetimes. The repulsive excited state of 2 Σ + 1/2 (or 2 Σ + g,1/2 ) symmetry in these van der Waals systems is likely to play an important role in the pumping of the blue side of the ns 2 S 1/2 → np 2 P 3/2 transition, which eventually may give rise to the np 2 P 1/2 → ns 2 S 1/2 lasing transition.

  18. Studies of the endothelial origin of cells in systemic angioendotheliomatosis and other vascular lesions of the brain and meninges using ulex europaeus lectin stains.

    Science.gov (United States)

    Schelper, R L; Olson, S P; Carroll, T J; Hart, M N; Witters, E

    1986-01-01

    Ulex europaeus agglutinin I (UEA-I) is a plant lectin which binds specifically to alpha-L-fucose moieties on the surface glycoproteins of human endothelial cells. The binding is completely inhibited by preincubation of the lectin with fucose. UEA-I can be conjugated directly to fluorescein or peroxidase and can be used to stain endothelium of paraffin embedded tissues. UEA-I staining was evaluated on normal and infarcted brain, systemic angioendotheliomatosis, metastatic epidural angiosarcoma, hemangioendothelioma, hemangioblastoma, angioblastic meningioma of both the hemangioblastic and hemangiopericytic types, and vascular meningioma. The endothelium, but not neuropil of normal and infarcted brain was positive for UEA-I. The tumor cells of hemangioendothelioma and angiosarcoma also stained. However, no staining was seen in malignant intravascular cells of angioendotheliomatosis, the stromal cells of hemangioblastoma, or pericytes of angioblastic meningioma. It is concluded that the malignant cells in angioendotheliomatosis, the stromal cells of hemangioblastoma and the pericytes of angioblastic meningioma do not produce surface glycoproteins characteristic of endothelial cells.

  19. An Unusual Case of Hepatic Tumor in an Elderly Patient

    Directory of Open Access Journals (Sweden)

    Huan-Lin Chen

    2009-09-01

    Full Text Available Malignant epithelioid hemangioendothelioma is a rare hepatic tumor of vascular origin. It is most commonly found in young to middle-aged women, and the tumors vary in their reported potential for malignancy. The etiologic factors are not yet clear, and some investigators have suggested an association with oral contraceptives, whereas others have noted an association with exposure to vinyl chloride, asbestos, thorotrast, major trauma to the liver, viral hepatitis, primary biliary cirrhosis, and alcohol consumption. The clinical manifestations are nonspecific, and most are asymptomatic. Among symptomatic patients, the most common symptom is right upper quadrant pain, followed by jaundice, weight loss, fatigue, ascites, hepatomegaly, and fever. The only definitive diagnosis requires immunohistochemical evidence of endothelial differentiation, which is demonstrated by the presence of factor VIII-related antigen and cytokeratins. As with most mesenchymal tumors, surgical resection is the most effective means of controlling local disease and preventing distant metastasis, although adjuvant therapies have been offered for patients with unresectable tumors or who are not transplant candidates. We present the case of an elderly man with a hepatic malignant epithelioid hemangioendothelioma, and we reviewed the English-language literature.

  20. Effectiveness of Vascular Markers (Immunohistochemical Stains) in Soft Tissue Sarcomas.

    Science.gov (United States)

    Naeem, Namra; Mushtaq, Sajid; Akhter, Noreen; Hussain, Mudassar; Hassan, Usman

    2018-05-01

    To ascertain the effectiveness of IHC markers of vascular origin like CD31, CD34, FLI1 and ERG in vascular soft tissue sarcomas including angiosarcomas, Kaposi sarcomas, epithelioid hemangioendothelioma and a non-vascular soft tissue sarcoma (Epithelioid sarcoma). Descriptive study. Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from 2011 to 2017. Diagnosed cases of angiosarcomas (n=48), epithelioid hemangioendothelioma (n=9), Kaposi sarcoma (n=9) and epithelioid sarcoma (n=20) were selected. Immunohistochemical staining as performed on formalin fixed paraffin embedded sections. The sections were stained for the following markers: CD34 (VENTANA clone Q Bend 10), CD31 (Leica clone 1 A 10), FLI1 (CELL MARQUE clone MRQ-1) and ERG (CELL MARQUE clone EP111). A complete panel of CD34, CD31 and ERG was applied on 8/48 cases of angiosarcomas with triple positivity in 6 cases. Eight cases showed positivity for only CD31 and ERG and 2 cases showed positivity for only ERG. A complete panel of CD34, CD31 and ERG was applied on 3/9 cases of epithelioid hemangioendothelioma with positivity for all markers in 2 cases. Combined positivity for ERG and CD34 was seen in 2 cases and on 4 cases only CD31 immunohistochemical was solely applied with 100% positivity. FLI1 was not applied on any case. Among 9 cases of Kaposi sarcoma, ERG, CD34 and CD31 in combination were applied on only 1 case with triple positivity. Remaining cases show positivity for either CD34, CD31 or FLI1. Majority of cases of epithelioid sarcomas were diagnosed on the basis of cytokeratin and CD34 positivity with loss of INI1. The other vascular markers showed negativity in all cases. Among these four markers, ERG immunohistochemical stain is highly effective for endothelial differentiation due to its specific nuclear staining pattern in normal blood vessel endothelial cells (internal control) as well as neoplastic cells of vascular tumors and lack of background staining.

  1. Differential diagnosis of liver tumors. 7

    International Nuclear Information System (INIS)

    Gratz, K.F.; Schober, Otmar; Ringe, Burckhard

    1991-01-01

    Liver own tumors were classified by histological criteria considering the tissue origin. hemangioma and hemangioendothelioma are of mesenchymal origin, the focal nodular hyperplasia (FNH), the hepato-blastoma, hepatocellular adenoma (HCA) or carcinoma (HCC), intrahepatic bile duct cystadenoma or carcinoma are epithelial tumors. Only the hemangioma and the FNH have an unhesitating prognosis. All the other tumors should be diagnosed definitively by histological examination. This means, the tumor has to be resected if possible. To answer the question of resectability radionuclide procedures contribute little. US, transmission tomography, magnetic resonance imaging and angiography are necessary in this case. This chapter deals with findings and problems involved with the use of radionuclide methods. (author). 28 refs.; 5 figs.; 6 tabs

  2. Rare primary malignant tumors of the liver

    International Nuclear Information System (INIS)

    Dahan, H.; Zoppardo, P.; Chagnon, S.; Vilgrain, V.; Blery, M.

    1991-01-01

    Angiosarcoma, epithelioid hemangio-endothelioma (EHE) and fibrolamellar carcinoma (FLC) are far less frequent malignant primary tumors of the liver than liver-cell carcinoma, and usually do not occur in a chronic liver disease. Their diagnosis is histological but a few radiological criteria are suggestive: in younger subjects, a solitary, hypervascularized mass containing calcifications and/or a central fibrous scar suggests an FLC; nodular lesions merging into patches, scattered about the periphery, containing calcified clusters and showing a low and late contrast enhancement after injections suggest an EHE; lastly, in case of occupational exposure, an heterogeneous, hypervascularized mass with a centripetal blush but containing central areas that are opacified early should suggest angiosarcoma. (4 figs) [fr

  3. [High-grade small bowel angiosarcoma associated with angiosarcomatosis: a case report].

    Science.gov (United States)

    Chahbouni, Sanae; Barnoud, Raphaëlle; Watkin, Emmanuel; Devouassoux-Shisheboran, Mojgan

    2011-08-01

    Angiosarcoma is a rare soft-tissue neoplasm occurring most often in the skin and the subcutaneous tissues and very rarely in the gastrointestinal tract. We report a case of a 25-year-old woman who presented with a small intestinal angiosarcoma associated with angiosarcomatosis. The diagnosis was established on surgical intestinal resection, that showed a high-grade angiosarcoma with epithelioid component and foci of agressive form of hemangioendothelioma. Immunohistochemical study revealed tumour cell positivity with endothelial markers CD31 and factor VIII whereas CD34 and epithelial markers were negative. The tumour displayed KIT (CD117) immunoreactivity without KIT or PDGFRA mutation on molecular analysis. Clinical and pathological features as well as differential diagnosis of this rare entity in gastrointestinal tract are discussed. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  4. Cytogenetic and molecular-genetic aberrations in malignant primary bone tumors

    International Nuclear Information System (INIS)

    Zoubek, A.; Kovar, H.; Gadner, H.

    1998-01-01

    Osteosarcoma, chondrosarcoma and tumors of the Ewing group are the most frequently observed primary malignant bone tumors. In an Internet homepage recently constructed for the Orthopedic Hospital Rizzoli Bologna, Italy, these tumors have represented the majority of 4423 malignant bone tumors in the archives of this institution since 1920 (http://www.tizeta.it/rizzoli). Malignant fibrous histiocytoma, fibrosarcoma, hemangioendothelioma, malignant hemangiopericytoma and giant-cell tumors are diagnosed less frequently. Since the introduction of modern molecular and cytogenic techniques, knowledge of genetic aberrations in malginant bone tumors has steadily increased. However, so far only for the group of Ewing tumors has a recurrent chromosomal marker, the translocation t(11; 22)(q24; q12), been identified. (orig.) [de

  5. Binary and ternary recombination of D3+ ions with electrons in He-D2 plasma

    Science.gov (United States)

    Glosík, J.; Korolov, I.; Plašil, R.; Kotrík, T.; Dohnal, P.; Novotný, O.; Varju, J.; Roučka, Š.; Greene, Chris H.; Kokoouline, V.

    2009-10-01

    An experimental study is reported about the recombination of D3+ ions with electrons in a low-temperature plasma (200-300 K) consisting of He with a small admixture of D2 . At several temperatures, the pressure dependence of the apparent binary recombination rate coefficient (αeff) was measured over a broad range of helium pressures (200-2000 Pa). The binary and ternary recombination rate coefficients were obtained from measured pressure dependences of αeff . The binary recombination rate coefficient obtained αbin(300K)=(2.7±0.9)×10-8cm3s-1 is in agreement with recent theory. The ternary recombination rate coefficient obtained is KHe(300K)=(1.8±0.6)×10-25cm6s-1 . In analogy with the recently described process of helium-assisted ternary recombination of H3+ ions, it is suggested that the ternary helium-assisted recombination of D3+ ions proceeds through the formation of a neutral long-lived highly excited Rydberg molecule D3 followed by a collision with a He atom.

  6. Magnetic resonance imaging of syrinx cavity. Differentiation between syrinx with spinal cord tumor and without tumor

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Teruo; Inoue, Yuichi; Nemoto, Yutaka

    1987-12-01

    Syrinx cavity may result from a number of intramedullary tumors or non-neoplastic conditions such as Chiari malformation, trauma and meningitis. The surgical procedure to repair the syrinx is quite different between the cases with spinal cord tumor and without tumor. Therefore, it is important to determine whether syrinx is associated with tumor or not before surgery. We reviewed MR images of 26 cases with syrinx cavity; 20 of which were not associated with tumor (12 Chiari malformation, 5 trauma, 1 meningitis, 1 hydrocephalus, 1 idiopathic) and 6 of which were associated with intramedullary tumor (3 ependymoma, 2 astrocytoma, 1 hemangioendothelioma). The syrinx showed low signal in all 26 cases on T1 weighted images (SE 600/40). All 6 cases with syrinx associated with intramedullary tumor showed high intensity on T2 weighted images (SE 2000/120). On the other hand, the syrinx of 19 of 20 cases with no tumor condition showed reduced intensity on T2 weighted images. Only one post-traumatic small syrinx showed high signal. This was quite different between the cases with spinal cord tumor and without tumor. Therefore, when the syrinx cavity shows high signal on T2 weighted images, an intramedullary tumor is strongly suggested.

  7. Magnetic resonance imaging of syrinx cavity

    International Nuclear Information System (INIS)

    Fukuda, Teruo; Inoue, Yuichi; Nemoto, Yutaka

    1987-01-01

    Syrinx cavity may result from a number of intramedullary tumors or non-neoplastic conditions such as Chiari malformation, trauma and meningitis. The surgical procedure to repair the syrinx is quite different between the cases with spinal cord tumor and without tumor. Therefore, it is important to determine whether syrinx is associated with tumor or not before surgery. We reviewed MR images of 26 cases with syrinx cavity; 20 of which were not associated with tumor (12 Chiari malformation, 5 trauma, 1 meningitis, 1 hydrocephalus, 1 idiopathic) and 6 of which were associated with intramedullary tumor (3 ependymoma, 2 astrocytoma, 1 hemangioendothelioma). The syrinx showed low signal in all 26 cases on T1 weighted images (SE 600/40). All 6 cases with syrinx associated with intramedullary tumor showed high intensity on T2 weighted images (SE 2000/120). On the other hand, the syrinx of 19 of 20 cases with no tumor condition showed reduced intensity on T2 weighted images. Only one post-traumatic small syrinx showed high signal. This was quite different between the cases with spinal cord tumor and without tumor. Therefore, when the syrinx cavity shows high signal on T2 weighted images, an intramedullary tumor is strongly suggested. (author)

  8. Epithelioid hemangioma of bone: radiologic and magnetic resonance imaging characteristics with histopathological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Schenker, Kathleen; Blumer, Steven [Nemours/Alfred I. duPont Hospital for Children, Department of Radiology, Wilmington, DE (United States); Jaramillo, Diego [Nicklaus Children' s Hospital, Department of Radiology, Miami, FL (United States); Treece, Amanda L. [University of Colorado School of Medicine, Departments of Pathology and Laboratory Medicine, Children' s Hospital Colorado, Aurora, CO (United States); Bhatia, Aashim [Monroe Carell Jr. Children' s Hospital at Vanderbilt, Department of Radiology, Nashville, TN (United States)

    2017-11-15

    Epithelioid hemangioma is a rare vascular tumor that can occur in soft tissues or bone. The tumor is part of a spectrum of vascular tumors that also includes epithelioid hemangioendothelioma and angiosarcoma. When involving the bone, the tumor usually involves the metaphysis or diaphysis of the long tubular bones and most commonly occurs in adults. It has been rarely reported in pediatric patients, and in these reported patients, the tumor primarily involves the epiphysis. To review three cases of epithelioid hemangioma of bone occurring in pediatric patients involving the epiphysis and to explore the imaging features of this tumor. Retrospectively review three cases of epithelioid hemangioma occurring in skeletally immature patients. These tumors primarily involved the epiphyses or epiphyseal equivalent bones. One lesion was centered in the metaphysis but extended to the epiphysis. These are three cases presenting in an unusual location and at an unusual age. Epithelioid hemangioma, though rare, can occur in pediatric patients and appears to involve the epiphyses in these patients. This is in contrast to the usual age and location reported. Epithelioid hemangioma may be considered for an epiphyseal lesion in a skeletally immature patient. (orig.)

  9. Pediatric liver neoplasms: a radiologic-pathologic correlation

    International Nuclear Information System (INIS)

    Helmberger, T.K.; Reiser, M.F.; Ros, P.R.; Mergo, P.J.; Tomczak, R.

    1999-01-01

    Only 1-2 % of all pediatric tumors occur in the liver. Two thirds of these tumors are malignant and almost all of the tumors cause clinical symptoms due to their mass effects. Besides the poor prognosis in most of the malignant tumors, for further treatment the origin and nature of the neoplasm has to be known. Due to the mostly unimpeded growth into the peritoneal cavity, the origin of the tumors is primarily often unclear and can non-invasively only be determined by advanced imaging techniques. The display of the macro- and microhistological key features of primary pediatric liver neoplasms, including hepatoblastoma (HB), infantile hemangioendothelioma (IHE), mesenchymal hamartoma (MH), undifferentiated (embryonal) sarcoma (UES), and hepatocellular carcinoma (HCC), together with their imaging representation by ultrasound, computed tomography, and magnetic resonance imaging, may deepen the understanding of the underlying pathology and its imaging appearance. Furthermore, in many cases sufficient information may be provided not only to differentiate benign from malignant tumors, but also to guide for adequate treatment. (orig.)

  10. Statistical analysis of Japanese Thorotrast-administered autopsy cases

    International Nuclear Information System (INIS)

    Mori, T.; Kato, Y.; Shimamine, T.; Watanabe, S.

    1979-01-01

    The causes of death of 144 Japanese autopsy cases during 1945-1975, who had been intravascularly injected with Thorotrast in life, were compared with those of non-Thorotrast-administered autopsy cases in the same age bracket, recorded in the Annals of Japanese Pathological Autopsy Cases during 1958-1973. This comparison revealed that the incidence of malignant hepatic tumors was more than 10 times higher in the Thorotrast-administered cases. The increase was attributable to an increased incidence of hemangioendothelioma and cholangiocarcinoma of the liver. The only significant increase of liver cirrhosis found to exist in the Thorotrast group occurred in the female cases. Some of the Thorotrast-administered cases were found to have developed myeloid leukemia and erythroleukemia. There was also a significant increase in the number of cases of aplastic anemia in the Thorotrast group, but clinically and pathologically these were atypical. Lymphatic leukemia was not observed. No significant difference was found in the incidence of either malignant lymphomas or osteosarcomas in the Thorotrast group and the controls. Lung cancer, on the other hand, showed a significantly higher incidence among the controls than among the Thorotrast-administered cases

  11. Affinity cytochemistry of vascular endothelia in brain tumors by biotinylated Ulex europaeus type I lectin (UEA I).

    Science.gov (United States)

    Weber, T; Seitz, R J; Liebert, U G; Gallasch, E; Wechsler, W

    1985-01-01

    The vascularization of 50 tumors of the central nervous system (CNS) including 17 meningiomas, 25 neuroectodermal tumors, i.e., astrocytomas, oligodendrogliomas, mixed gliomas, glioblastomas, medulloblastomas, seven metastatic carcinomas, and one malignant hemangioendothelioma were investigated using biotinylated Ulex europaeus type I lectin (UEA I) in an indirect avidinbiotin-peroxidase procedure. The cytochemical staining pattern of UEA I on paraffin sections was compared with that of biotinylated Dolichos biflorus lectin (DBA), and with the immunocytochemical staining of factor VIII related antigen (F VIII/RAG) by polyclonal antisera using the PAP technique. UEA I visualized the endothelia of blood vessels with equal intensity, sensitivity, and reliability in normal brain and in tumor tissue with neovascularization. While large, medium, and small vessels were equally well demonstrated by UEA I and antibodies against FVIII/RAG, capillaries and endothelial sprouts were stained more consistently and intensely by UEA I. No reliable cytochemical staining could be obtained by DBA regardless of tissue or cell type investigated. It is concluded that UEA I is a highly useful cytochemical marker for the identification of vascular endothelia in paraffin sections of human brain tumors.

  12. Surgical management of gynecomastia--a 10-year analysis.

    Science.gov (United States)

    Handschin, A E; Bietry, D; Hüsler, R; Banic, A; Constantinescu, M

    2008-01-01

    Gynecomastia is defined as the benign enlargement of the male breast. Most studies on surgical treatment of gynecomastia show only small series and lack histopathology results. The aim of this study was to analyze the surgical approach in the treatment of gynecomastia and the related outcome over a 10-year period. All patients undergoing surgical gynecomastia corrections in our department between 1996 and 2006 were included for retrospective evaluation. The data were analyzed for etiology, stage of gynecomastia, surgical technique, complications, risk factors, and histological results. A total of 100 patients with 160 operations were included. Techniques included subcutaneous mastectomy alone or with additional hand-assisted liposuction, isolated liposuction, and formal breast reduction. Atypical histological findings were found in 3% of the patients (spindle-cell hemangioendothelioma, papilloma). The surgical revision rate among all patients was 7%. Body mass index and a weight of the resected specimen higher than 40 g were identified as significant risk factors for complications (p gynecomastia requires an individualized approach. Caution must be taken in performing large resections, which are associated with increased complication rates. Histological tissue analysis should be routinely performed in all true gynecomastia corrections, because histological results may reveal atypical cellular pathology.

  13. Injury due to thorotrast

    International Nuclear Information System (INIS)

    Mori, Takesaburo

    1976-01-01

    A synthetic study was performed on some of those to whom Thorotrast had been injected, in Japan. In the epidemiological study of 147 war woundeds to whom Thorotrast had been injected, it was noted that the Thorotrast injection increased the mortality rate and the incidences of malignant hepatic tumor, liver cirrhosis, and hematological diseases. Clinical study of 44 of them showed that the Thorotrast injection resulted in liver and hematopoietic hypofunctions. Analysis of the dissection of the injected area in 118 cases showed malignant hepatic tumor in 63.5%, liver cirrhosis in 14.4% and hematological diseases in 10.2%. The total of the three types of disease was 88.1%. Histological classification showed that of the malignant hepatic tumors due to Thorotrast, hepatobiliary cancer and hemangioendothelioma of the liver were frequent. By the comparison of the absorbed dose in the liver of the malignant hepatic tumors due to Thorotrast with that of the cancers developed in animal experiments, it was noted that the carcinogenic dose was a mean of 2,000 - 3,000 rad by accumulated dose. It was elucidated that carcinogenesis and fibrination were primary in injury due to Thorotrast, i.e., late injury due to Thorotrast, and that the increase in the accumulated dose in rogans and the increase of the local dose due to the gigantic growth of Thorotrast granules in organs greatly influenced carninogenesis and fibrination. (Chiba, N.)

  14. Imaging tumors of the patella

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, R., E-mail: roberto.casadei@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Kreshak, J., E-mail: j.kreshak@yahoo.com [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rinaldi, R. [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rimondi, E., E-mail: eugenio.rimondi@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Bianchi, G., E-mail: giuseppe.bianchi@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Alberghini, M., E-mail: marco.alberghini@ior.it [Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Ruggieri, P. [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Vanel, D., E-mail: daniel.vanel@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy)

    2013-12-01

    Background: Patellar tumors are rare; only a few series have been described in the literature and radiographic diagnosis can be challenging. We reviewed all patellar tumors at one institution and reviewed the literature. Materials and methods: In an evaluation of the database at one institution from 1916 to 2009, 23,000 bone tumors were found. Of these, 41 involved the patella. All had imaging studies and microscopic diagnostic confirmation. All medical records, imaging studies, and pathology were reviewed. Results: There were 15 females and 26 males, ranging from 8 to 68 years old (average 30). There were 30 benign tumors; eight giant cell tumors, eight chondroblastomas, seven osteoid osteomas, two aneurysmal bone cysts, two ganglions, one each of chondroma, exostosis, and hemangioma. There were 11 malignant tumors: five hemangioendotheliomas, three metastases, one lymphoma, one plasmacytoma, and one angiosarcoma. Conclusion: Patellar tumors are rare and usually benign. As the patella is an apophysis, the most frequent lesions are giant cell tumor in the adult and chondroblastoma in children. Osteoid osteomas were frequent in our series and easily diagnosed. Metastases are the most frequent malignant diagnoses in the literature; in our series malignant vascular tumors were more common. These lesions are often easily analyzed on radiographs. CT and MR define better the cortex, soft tissue extension, and fluid levels. This study presents the imaging patterns of the more common patellar tumors in order to help the radiologist when confronted with a lesion in this location.

  15. Ultrasound-guided core needle biopsy in diagnosis of abdominal and pelvic neoplasm in pediatric patients.

    Science.gov (United States)

    Wang, Hailing; Li, Fangxuan; Liu, Juntian; Zhang, Sheng

    2014-01-01

    Ultrasound-guided core needle biopsy of abdominal and pelvic masses in adults has gained tremendous popularity. However, the application of the same treatment in children is not as popular because of apprehensions regarding inadequate tissues for the biopsy and accidental puncture of vital organs. Data of the application of ultrasound-guided core needle biopsy in 105 pediatric patients with clinically or ultrasound-diagnosed abdominopelvic masses were reviewed. Diagnostic procedures were conducted in our institution from May 2011 to May 2013. The biopsies were conducted on 86 malignant lesions and 19 benign lesions. 86 malignant tumors comprised neuroblastomas (30 cases), hepatoblastomas (15 cases), nephroblastomas (11 cases), and primitive neuroectodermal tumors/malignant small round cells (6 cases). Among malignant tumor cases, only a pelvic primitive neuroectodermal tumor did not receive a pathological diagnosis. Therefore, the biopsy accuracy was 98.8 % in malignant tumor. However, the biopsies for one neuroblastomas and one malignant small round cell tumor were inadequate for cytogenetic analysis. Therefore, 96.5 % of the malignant tumor patients received complete diagnosis via biopsy. 19 benign tumors comprised mature teratoma (10 cases), hemangioendothelioma (3 cases), paraganglioma (2 cases), and infection (2 cases). The diagnostic accuracy for benign neoplasm was 100 %. Five patients experienced postoperative complications, including pain (2 patients), bleeding from the biopsy site (2 patients), and wound infection (1 patient). Ultrasound-guided core needle biopsy is an efficient, minimally invasive, accurate, and safe diagnostic method that can be applied in the management of abdominal or pelvic mass of pediatric patients.

  16. Clinical courses and CT findings in the patients with contrast media-associated seizures

    International Nuclear Information System (INIS)

    Onda, Kiyoshi; Takeda, Norio; Tanaka, Ryuichi

    1987-01-01

    From February 1976 through March 1985, 12,479 patients underwent cranial computed tomography (CT) examinations with 65 % Angiografin (100 ml/kg for adults and 2 ml/kg for children). Among them, five patients experienced contrast media-associated seizures. The present study analyzed (1) the time of occurrence of seizures, (2) CT appearances at the time of seizures, (3) epileptogenecity, and (4) clinical features of seizures. Two patients had malignant gliomas, 2 metastatic brain tumors, and one hemangioendothelioma. Seizures occurred at CT examinations performed after the initial treatment, such as radiation or surgery, with the incidence for each patient varing from 2 to 5. There were lesions near the motor cortex on CT scans, and enhancement was observed in most cases. Three patients had experienced epilepsy attacks due to their underlying diseases. In the other two, contrast media-associated seizures preceded the occasional onset of epilepsy attacks. This strongly suggested the influence of their underlying diseases in the occurrence of contrast media-associated seizures. A careful use of contrast media for cranial CT examination is emphasized. (Namekawa, K.)

  17. Proximal-Type Epithelioid Sarcoma: Report of an Unusual Case in the Uterine Cervix.

    Science.gov (United States)

    Suárez-Zamora, David Alfonso; Barrera-Herrera, Luis Eduardo; Rodríguez-Urrego, Paula Andrea; Palau-Lázaro, Mauricio Alfonso

    2017-08-01

    Epithelioid sarcoma is a rare malignant mesenchymal neoplasm (less than 1% of all sarcomas) with epithelioid morphology. Among the 2 subtypes, proximal represents only one-third of cases and commonly involves deep tissues of pelvic region, including the perineum, genital area, and groin, and occurs more frequently in older patients who present a more aggressive course. In the female genital tract, proximal-type epithelioid sarcoma (PES) mainly affects the vulva and is extremely uncommon in the uterus. To our knowledge, only a few cases of PES involving the cervix and uterine body have been previously reported in the literature. We report a 23-year-old woman who presented with abnormal vaginal bleeding. She was found to have a cervical mass, which was resected and diagnosed as a hemangioendothelioma. However, 2 months later, the mass recurred and the histopathological analysis at our institution demonstrated a PES confined to the uterine cervix. It is important to include this neoplasm in the differential diagnosis of epithelioid tumors that can involve the female genital tract because it has a significant impact on prognosis and treatment.

  18. Real-time contrast-enhanced ultrasound in diagnosing of focal spleen lesions

    International Nuclear Information System (INIS)

    Yu Xiaoling; Yu Jie; Liang Ping; Liu Fangyi

    2012-01-01

    Objective: To investigate the features of focal spleen lesions (FSLs) on contrast-enhanced ultrasound (CEUS) imaging. Materials and methods: CEUS with a blot injection of SonoVue was performed in 48 patients with 75 FSLs (median diameter 2.6 cm) and their perfusion characteristics were analyzed by using contrast pulse sequences (CPS) technique. Results: Among 19 malignant lesions (10 metastases, 7 lymphoma, 1 hemangiosarcoma, 1 epithelioid hemangioendothelioma) and 56 benign lesion (23 hemangiomas, 14 cysts, 8 infarctions, 4 splenic ruptures, 3 tuberculosis, 2 abscess, 1 pseudoaneurysm, 1 lymphangioma), 25 benign lesions were demonstrated nonenhancement. For malignancy, 50.0% (5/10) metastases and 57.1% (4/7) lymphomas were showed hypoenhancement in the arterial phase, and 18 (94.7%) of malignant lesions were hypo-enhancement in the parenchymal phase. Among 31 benign lesions with enhancement, 27 (87.1%) were showed isoenhancement or hyperenhancement in the arterial phase and 22 (71.0%) lesions were isoenhancement or hyperenhancement in the parenchymal phase. The sensitivity, specificity and accuracy of diagnosis for FSLs were 91.1%, 95.0% and 92.0% for CEUS and 75.0%, 84.2% and 77.3% respectively, for the conventional baseline ultrasound (BUS). Conclusion: Real-time CEUS can provide valuable information for the diagnosis and differential diagnosis of FSLs.

  19. Tumors of the liver; a ten year study in Children Medical Center

    Directory of Open Access Journals (Sweden)

    Farahmand F

    2007-06-01

    Full Text Available Background: The aim of this study was to review the frequency, histopathology and outcome in children with tumors of the liver. Methods: Included in this retrospective/descriptive study were 30 children treated for liver tumors from 1375-1384 (ca. 1996-2005, at Children’s Hospital Medical Center, Tehran, Iran. We included the clinical, radiologic, and pathologic data of our patients, focusing on the frequency, etiology and outcome. Results: Patient ages ranged from three months to 12 years (median 3.8 years, with 18 males (60% and 12 females (40%. Of these, 17 patients had hepatoblastoma (55.66%, including 13 males and four females, with an age range of six months to five years. Four cases (13.33% had neuroblastoma. Hepatocellular carcinoma (HCC was found in three cases (10%, all of whom were carriers of hepatitis B. Two cases (6.66% were diagnosed with mesenchymal hamartoma, two cases (6.66% with hemangioendothelioma and two cases (6.66% with rhabdomyosarcoma and leiomyosarcoma of the biliary tract. Abdominal swelling and hepatomegaly were seen in all of patients. Jaundice was observed in two cases. Serum alpha-fetoprotein levels greater than 500 ng/ml were seen in 17 cases (56.66%. All patients were receiving specific treatment. The three-year survival rate was 65% for hepatoblastoma and 2% for HCC Conclusion: With the introduction of specific treatment, the survival rate for children with tumors of the liver has significantly increased. Further improvement can be achieved using diagnostic biopsy for hepatoblastoma, although it may result in complications, and preoperative chemotherapy followed by complete surgical excision (per International Society of Pediatric Oncology guidelines, yielding an outstanding survival rate of 80%.

  20. Development of a Google-based search engine for data mining radiology reports.

    Science.gov (United States)

    Erinjeri, Joseph P; Picus, Daniel; Prior, Fred W; Rubin, David A; Koppel, Paul

    2009-08-01

    The aim of this study is to develop a secure, Google-based data-mining tool for radiology reports using free and open source technologies and to explore its use within an academic radiology department. A Health Insurance Portability and Accountability Act (HIPAA)-compliant data repository, search engine and user interface were created to facilitate treatment, operations, and reviews preparatory to research. The Institutional Review Board waived review of the project, and informed consent was not required. Comprising 7.9 GB of disk space, 2.9 million text reports were downloaded from our radiology information system to a fileserver. Extensible markup language (XML) representations of the reports were indexed using Google Desktop Enterprise search engine software. A hypertext markup language (HTML) form allowed users to submit queries to Google Desktop, and Google's XML response was interpreted by a practical extraction and report language (PERL) script, presenting ranked results in a web browser window. The query, reason for search, results, and documents visited were logged to maintain HIPAA compliance. Indexing averaged approximately 25,000 reports per hour. Keyword search of a common term like "pneumothorax" yielded the first ten most relevant results of 705,550 total results in 1.36 s. Keyword search of a rare term like "hemangioendothelioma" yielded the first ten most relevant results of 167 total results in 0.23 s; retrieval of all 167 results took 0.26 s. Data mining tools for radiology reports will improve the productivity of academic radiologists in clinical, educational, research, and administrative tasks. By leveraging existing knowledge of Google's interface, radiologists can quickly perform useful searches.

  1. The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.

    Science.gov (United States)

    Travis, William D; Brambilla, Elisabeth; Nicholson, Andrew G; Yatabe, Yasushi; Austin, John H M; Beasley, Mary Beth; Chirieac, Lucian R; Dacic, Sanja; Duhig, Edwina; Flieder, Douglas B; Geisinger, Kim; Hirsch, Fred R; Ishikawa, Yuichi; Kerr, Keith M; Noguchi, Masayuki; Pelosi, Giuseppe; Powell, Charles A; Tsao, Ming Sound; Wistuba, Ignacio

    2015-09-01

    hemangioendotheliomas, (15) adding Erdheim-Chester disease to the lymphoproliferative tumor, and (16) a group of tumors of ectopic origin to include germ cell tumors, intrapulmonary thymoma, melanoma and meningioma.

  2. Impact of Pathologist Involvement in Sarcoma and Rare Tumor Patient Support Groups on Facebook: A Survey of 542 Patients and Family Members.

    Science.gov (United States)

    Haller, Jasmine; David, Marjorie Parker; Lee, Nathan E; Shalin, Sara C; Gardner, Jerad M

    2018-01-29

    - Patients with rare tumors have difficulty finding reliable information about their disease. Facebook patient support groups allow patients to educate one another. - To investigate how these patients perceive the value of pathologists, both in Facebook groups and real-world patient care. - Survey links were posted in 12 Facebook patient groups: 6 with an active pathologist member (angiosarcoma, epithelioid hemangioendothelioma, epithelioid sarcoma, dermatofibrosarcoma protuberans [×2], and desmoid fibromatosis), and 6 without "active" pathologist involvement (aggressive angiomyxoma, chondrosarcoma, Ewing sarcoma, leiomyosarcoma, liposarcoma, and osteosarcoma). - A total of 542 people responded (403 were patients): 264 from groups with a pathologist, and 278 from groups without active pathologist involvement. Of groups with an active pathologist, respondents agreed the pathologist's posts helped them better understand their disease (107 of 119; 90%) and relieved some of their disease-related anxiety (92 of 119; 77%). And for these groups 98% (117 of 119) of respondents agreed that having a pathologist in their group was a good thing; 83% (192 of 232) wanted more pathologists involved. More respondents from groups with an active pathologist (219 of 236; 93%) than without one (215 of 252; 85%) agreed: "pathologists are an important part of the patient care team for patients with cancer and other rare tumors" ( P = .008). - This study is the first to evaluate the impact of pathologist interaction with Facebook patient support groups and to assess perceptions about the specialty of pathology from a large group of patients with rare tumors. Pathologist involvement in Facebook patient groups appears to positively influence patient perception of the importance of pathologists. We hope these data will encourage more pathologists to participate in Facebook patient support groups.

  3. Vectors and malaria transmission in deforested, rural communities in north-central Vietnam

    Directory of Open Access Journals (Sweden)

    Do Manh Cuong

    2010-09-01

    Full Text Available Abstract Background Malaria is still prevalent in rural communities of central Vietnam even though, due to deforestation, the primary vector Anopheles dirus is uncommon. In these situations little is known about the secondary vectors which are responsible for maintaining transmission. Basic information on the identification of the species in these rural communities is required so that transmission parameters, such as ecology, behaviour and vectorial status can be assigned to the appropriate species. Methods In two rural villages - Khe Ngang and Hang Chuon - in Truong Xuan Commune, Quang Binh Province, north central Vietnam, a series of longitudinal entomological surveys were conducted during the wet and dry seasons from 2003 - 2007. In these surveys anopheline mosquitoes were collected in human landing catches, paired human and animal bait collections, and from larval surveys. Specimens belonging to species complexes were identified by PCR and sequence analysis, incrimination of vectors was by detection of circumsporozoite protein using an enzyme-linked immunosorbent assay. Results Over 80% of the anopheline fauna was made up of Anopheles sinensis, Anopheles aconitus, Anopheles harrisoni, Anopheles maculatus, Anopheles sawadwongporni, and Anopheles philippinensis. PCR and sequence analysis resolved identification issues in the Funestus Group, Maculatus Group, Hyrcanus Group and Dirus Complex. Most species were zoophilic and while all species could be collected biting humans significantly higher densities were attracted to cattle and buffalo. Anopheles dirus was the most anthropophilic species but was uncommon making up only 1.24% of all anophelines collected. Anopheles sinensis, An. aconitus, An. harrisoni, An. maculatus, An. sawadwongporni, Anopheles peditaeniatus and An. philippinensis were all found positive for circumsporozoite protein. Heterogeneity in oviposition site preference between species enabled vector densities to be high in both

  4. Methane and carbon dioxide fluxes over a lake: comparison between eddy covariance, floating chambers and boundary layer method

    Directory of Open Access Journals (Sweden)

    K.-M. Erkkilä

    2018-01-01

    Full Text Available Freshwaters bring a notable contribution to the global carbon budget by emitting both carbon dioxide (CO2 and methane (CH4 to the atmosphere. Global estimates of freshwater emissions traditionally use a wind-speed-based gas transfer velocity, kCC (introduced by Cole and Caraco, 1998, for calculating diffusive flux with the boundary layer method (BLM. We compared CH4 and CO2 fluxes from BLM with kCC and two other gas transfer velocities (kTE and kHE, which include the effects of water-side cooling to the gas transfer besides shear-induced turbulence, with simultaneous eddy covariance (EC and floating chamber (FC fluxes during a 16-day measurement campaign in September 2014 at Lake Kuivajärvi in Finland. The measurements included both lake stratification and water column mixing periods. Results show that BLM fluxes were mainly lower than EC, with the more recent model kTE giving the best fit with EC fluxes, whereas FC measurements resulted in higher fluxes than simultaneous EC measurements. We highly recommend using up-to-date gas transfer models, instead of kCC, for better flux estimates. BLM CO2 flux measurements had clear differences between daytime and night-time fluxes with all gas transfer models during both stratified and mixing periods, whereas EC measurements did not show a diurnal behaviour in CO2 flux. CH4 flux had higher values in daytime than night-time during lake mixing period according to EC measurements, with highest fluxes detected just before sunset. In addition, we found clear differences in daytime and night-time concentration difference between the air and surface water for both CH4 and CO2. This might lead to biased flux estimates, if only daytime values are used in BLM upscaling and flux measurements in general. FC measurements did not detect spatial variation in either CH4 or CO2 flux over Lake Kuivajärvi. EC measurements, on the other hand, did not show any spatial variation in CH4 fluxes but did show a clear difference

  5. Assessing the impact of climate change on the water intake of the headworks on the Red River Basin in Viet Nam

    Directory of Open Access Journals (Sweden)

    Pham Thi Huong Lan

    2017-01-01

    Full Text Available The irrigation systems for the Red River Delta usually get water by pumping and gravity.The results determine the possible minimum water level line in the dry-season months under climate change scenarios (B2, SC5 and SC6 and current scenario is B2, SC4 on the river system of the Red River – Thai Binh River in study areas of project as below: Water levels on the Red River in the dry season under climate change scenarios significantly reduced compared with 2010. At Ha Noi station on Red River, the water levels reduce in 2050 about 6.5cm (B2 and 7.5cm (A2 and 6cm (B1. At Nam Dinh station on Dao River, the water levels reduce in 2050 about 4cm (B2 and 5cm (A2 and 3cm (B1. At Cat Khe on Thai Binh River, the water levels reduce in 2050 about 2cm (B2 and 3cm (A2 and 1.5cm (B1. At An Bai on Kinh Thay River, the water levels reduce in 2050 about 5cm (B2 and 6cm (A2 and 4cm (B1. At Truc Phuong on Ninh Co River, the water levels reduce in 2050 about 6.5cm (B2 and 7.2cm (A2 and 5.8cm (B1. In the scenario in which 50% of the socio-economic development plans are achieved (SC6, the water demand is lower than the scenario of full development (SC5. The decrease in the average water level in the whole Red River system is about 1.3-1.8 cm less than in SC5, and in Thai Binh river this figure is about 1.4-2.1cm. The lowering of the water level under climate change in the river has caused problems for irrigation during the dry season, in order to reach the target level in Hanoi.

  6. Angiossarcoma epitelióide ósseo: relato de um caso, com estudo imuno-histoquímico Epithelioid angiosarcoma of bone: report of a case with immunohistochemical study

    Directory of Open Access Journals (Sweden)

    Cláudia Regina G. C. M. de Oliveira

    2001-03-01

    Full Text Available Angiossarcoma primário do osso é muito raro, representando menos de 1% de todos os angiossarcomas(4. Neoplasias vasculares também são incomuns, ocorrendo em 14% dos tumores malignos primários do osso. Os autores relatam caso em coluna lombar que merece atenção porque inicialmente tratava-se de um hemangioendotelioma, um tumor de malignidade intermediária, definido pelos critérios estabelecidos por Stout(11. Foi tratado com embolização local e radioterapia. Após dez anos, recidivou, com maior grau de malignidade, fenômeno interpretado como progressão tumoral, com características de Angiossarcoma epitelióide. O estudo imuno-histoquímico revelou positividade para marcadores vasculares. (Fator VIII, CD31 e CD34. O paciente evoluiu com metástases pulmonares. Em revisão bibliográfica, não foi encontado nenhum relato de caso semelhante, tendo em vista a longa evolução e progressão tumoral após dez anos de seguimento e expressão do fenotipo epitelióide.Primary angiosarcoma of bone is rare and accounts for less than 1% of all angiosarcomas(4. Vascular bone neoplasms represent 1,4% of primary malignant bone tumors. The authors describe an unusual case of bone angiosarcoma located in the spine. The diagnosis was initially hemangioendothelioma, a borderline endothelial vascular tumor, as stated by Stout(11. The lesion was treated by local embolization and radiation therapy. The tumor recurred locally ten years later as a high-grade angiosarcoma, showing epithelioid features, which indicates tumor progression. Immunohistochemical studies were positive for vascular markers such as factor VIII, CD31 and CD 34. The patient developed lung metastasis. I was not observed in the literature any other case with ten-year follow-up and tumor progression with epithelioid features.

  7. Hemangioendotelioma epitelióide do pulmão – Raridade, dificuldades diagnósticas e terapêutica

    Directory of Open Access Journals (Sweden)

    Telma Lopes

    2009-11-01

    highlight the rarity of this pulmonary neoplasm and the importance of clinical suspicion, and the diagnosis and treatment difficulties in addition to the potential benefits of antiangiogenic drugs.Rev Port Pneumol 2009; XV (6: 1167-1174 Palavras-chave: Hemangioendotelioma epitelióide, angiossarcoma do pulmão, asbestos, bevacizumab, Key-words: Epithelioid hemangioendothelioma, pulmonary angiosarcoma, asbestos, bevacizumab

  8. EDITORIAL: From reciprocal space to real space in surface science From reciprocal space to real space in surface science

    Science.gov (United States)

    Bartels, Ludwig; Ernst, Karl-Heinz

    2012-09-01

    cover image of this issue honors this achievement. It shows 27 chiral heptahelicene molecules arranged by one of the guest editors (KHE) with the very same STM at IBM Almaden Research Center, San José that was used for moving xenon atoms more than 20 years ago. Karl-Heinz Rieder's career, as briefly outlined in the biography by G Benedek in this issue, reflected this paradigm shift in surface science from reciprocal to real space investigations: initially focusing on helium scattering as a superior technique for the investigation of delicate surfaces, his group at the Freie University in Berlin became the second in the world to rearrange atoms and molecules at surfaces in a controlled way and they generated much of the foundational work of low temperature STM investigations. Besides his saxophone skills and many other hobbies, Karl-Heinz is a real poet and loves composing funny limericks and spoonerisms. He wrote the following poem (passed on to us by W-D Schneider) at the International School of Solid State Physics in 1998 in Erice, Italy. It is a real masterpiece, beautifully summarizing us all, the 'Surface Science Society'. The top atom sheetSome become real slaves is important and neat.looking at standing waves. Therefore there is a strong raceThe producers of coatings in the science of surface.get really good quotings. To clean it you needStill others use new ways ions and heat.with electrons and x-rays. Then the atoms arrangeAnd all has to be in some ways that are strange,in good UHV—except theory, they relax, reconstructwhich thinks on extensions as a matter of fact.to still lower dimensions, And reacting with gasesand with lots of computing they form quite new phasestries to get solid footing. with large unit cellsSo everybody with joy as diffraction tells.plays his own special toy. Some people use lightAnd all think they are better from a synchrotron brightshould get published a letter. and claim it is bestBut before there's more cluster to do this in

  9. Removal of radiostrontium from man; Elimination du radiostrontium de l'organisme humain; Vyvedenie radioaktivnogo strontsiya iz organizma cheloveka; Eliminacion del radioestroncio por el organismo humano

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, H. [Edward Hines, Jr. Hospital Hines, IL (United States)

    1963-02-15

    normal que se ofrecieron como voluntarios. En este estudio no se administraron radioisotopos. Los resultados relativos al {sup 90}Sr son analogos a los conseguidos con el 8{sup 5}Sr. (author) [Russian] Issledovanie obmena radiostrontsiya u cheloveka proizvodilos' pri postoyannom kontrole.obmena i diety. V kachestve radioaktivnogo indikatora byl ispol'zovan otnositel'no korotkokhivushchij izotop Sreb. Odnokratnye indikatornye dozy Sr{sup 85} vvodilis' vnutrivenno i davalis' vnutr', posle chego opredelyalsya uroven' ego v plazme i vydelenie s mochoj i kalom. Osnovnoe kolichestvo Sr{sup 85} vyvoditsya pochkami, nezavisimo ot puti vvedeniya indikatora. U bol'shinstva obsledovannykh v srednem 20% prinyatogo vnutr' kolichestva Sr{sup 85} poglashchalos' iz kishechnika i priblizitel'no 50% pogloshchennoj dozy vydelyalos' s mochoj za 12 dnej. Issledovaniya, v protsesse kotorykh indikatornye dozy Sr{sup 85} i Ca{sup 45} byli odnovremenno vvedeny per oa, ukazali na predpochtenie organizma k pogloshcheniyu Ca{sup 45} i k vydeleniyu Sr{sup 85}, prichem sootnoshenie po- gloshcheniya Ca{sup 45}/Sr{sup 85} sostavlyaet 2,6:1. Zakonchivshiesya issledovaniya Sr{sup 85} vo vremya priema bol'shikh i malykh doz kal'tsiya odnimi i temi khe litsami pokazali, chto priem bol'shogo kolichestva kal'tsiya ne vedet k kakomulibo zametnomu izmeneniyu v pogloshchenii Sr{sup 85} u bol'shinstva obsledovannykh. Poskol'ku vydelenie Sr{sup 85} mochoj idet parallel'no vydeleniyu kal'tsiya, okazalos' vozmozhnym uvelichit' soderzhanie kal'tsiya v moche s pomoshch'yu razlichnykh veshchestv, povyshayushchikh kal'tsiuriyu. Vvedennye vnutrivenno stabil'nye kal'tsij i strontsij i prinyatyj per os khloristyj ammonij, primenennye v chistom vide ili v sochetanii s vnutrivenno vvedennymi kal'tsiem i nekotorymi kompleksoobrazuyushchimi veshchestvami, okazalis' ehffektivnymi v otnoshenii udaleniya radiostrontsiya u cheloveka v period ot dvukh do chetyrekh nedel' posle inektsii indikatora. Proizvedeny takzhe issledovaniya

  10. The Performance of Major Plant Items at Calder Hall; Fonctionnement des elements principaux de la centrale de Calder Hall; Kharakteristika osnovnykh uzlov ustanovki v Kolder-Kholle; Rendimiento de los principales elementos de la central de Calder Hall

    Energy Technology Data Exchange (ETDEWEB)

    Desbruslais, E. L. [United Kingdom Atomic Energy Authority, Seascale, Cumberland (United Kingdom)

    1963-10-15

    elementos mas importantes de la central contra danos accidentales que puedan provenir de fuentes externas. Para el generador diesel de emergencia, no parece necesario prever un arranque automatico o circuitos paralelos, si bien una centralizacion no seria superflua. (author) [Russian] V techenie svyshe shesti let bol'shaya ustanovka v Kolder-Kholle ehkspluatiruetsya kak ehnergeticheskaya ustanovka s bazovoj nagruzkoj. Na nej voznikali takie khe povrezhdeniya, kak i na obychnykh ehnergeticheskikh ustanovkakh. Vse povrezhdeniya imeli mesto v obychnoj ustanovke i ni odnogo - v samikh yadernykh reaktorakh. Opyt pokazal, chto s tochki zreniya bezopasnosti reaktory i osnovnye uzly ustanovki vmeste s privodami sistemy neobkhodimo rassmatrivat' v tselom. Ne obnaruzheno nikakikh sushchestvennykh izmenenij, kotorye by davali povod dumat' o tom, chto korpus vysokogo davleniya reaktora ili grafitovyy zamedlitel' ogranichat srok ehkspluatatsii ustanovki. Asimmetrichnoe raspredelenie temperatury imeet mesto vokrug vykhodnykh gazovykh truboprovodov, i v nastoyashchee vremya ehto ogranichivaet moshchnost' reaktora. Rekomenduetsya ustanovit' vnachale dopolnitel'noe kolichestvo termopar, kontrol'no-izmeritel'nye pribory dlya opredeleniya napryazheniya i obespechit' vizual'noe nablyudenie za oblastyami vysokogo napryazheniya i temperatury. V khode normal'noj ehkspluatatsii osushiteli bol'she ne primenyayutsya, i sootvetstvenno v rezul'tate ehtogo dostignuto nebol'shoe uvelichenie moshchnosti reaktora. Dastsya rekomendatsii otnositel'no periodichnosti obsledovanij teploobmennikov, osnovnykh gazovykh truboprovodov i nizhnikh uzlov. Nebol'shoe uvelichenie v proizvodstve para dostignuto v rezul'tate umen'sheniya perepuska gaza. Nebol'shie trudnosti voznikli lish' pri ehkspluatatsii tsirkulyatorov gaza tsentrobezhnogo tipa. Otmecheno nebol'shoe snizhenie proizvodstva vnachale v rezul'tate krugovogo iskreniya kommutatorov pri vysokom napryazhenii na motorakh ventilyatorov i na generatorakh

  11. Radioisotopes and Radiation in Animal and Plant Insect Pest Control; Emploi des radioisotopes et des rayonnements dans la lutte contre les insectes nuisibles aux plantes et aux animaux; Ispol'zovanie radioizotopov i radiashchi v bor'be s nasekomymi-vreditelyami rastenij i zhivotnykh; Utilizacion de los radioisotopos y de las radiaciones en la lucha contra los insectos nocivos para las plantas y los animales

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, S. V.; Martens, B. K.; Samojlova, V. A.; Molchanova, Z. I. [Vsesoyuznyj Institut Zashchity Rastenij, Leningrad, SSSR (Russian Federation)

    1963-09-15

    plagas de insectos. La accion esterilizadora y letal de las radiaciones ionizantes puede ser muy eficaz en la lucha contra las plagas de insectos. Utilizando rayos gamma se han establecido las dosis esterilizadoras para toda una serie de insectos nocivos para los productos agricolas almacenados (Calandra granaria L., Acanthoscelides Obtectus Say, Pectinophora Malvella Hb., Leptinotarsa decemlineota Say, Chloridea obsoleta F.) y los cultivos. Los datos obtenidos con esas investigaciones serviran de base para elaborar y perfeccionar los metodos de lucha contra los insectos daninos para la agricultura. (author) [Russian] Problema bor'by s vreditelyami sel'skokhozyajstvennykh kul'tur imeet krupnoe narodnokhozyajstvennoe znachenie. Pri razreshenii ehtoj problemy osoboe znachenie priobretaet ispol'zovanie poslednikh dostizhenij nauki. V tselyakh ratsionalizatsii i povysheniya ehffektivnosti sushchestvuyushchikh metodov bor'by s vrednymi nasekomymi byli ispol'zovany radioaktivnye izotopy i izlucheniya. Ispol'zovanie radioaktivnykh izotopov i izluchenij yavlyaetsya moguchim sredstvom ratsionalizatsii i'povysheniya ehffektivnosti sushchestvuyushchikh metodov bor'by s vrednymi nasekomymi. Razrabotka ehtikh metodov vyzyvaet neobkhodimost' detal'nogo izucheniya voprosov bioehkologii, toksikologii i t.d. V oblasti bioehkologii ves'ma perspektivnym yavlyaetsya metod radiomarkirovki nasekomykh. Primenenie radioizotopov dlya markirovki nasekomykh vreditelej zernovykh kul'tur (Eurygaster integriceps Put, Hadena sordida Skh.) i ikh parazitov (Meniscus agriatus Crow, Psendogonia cinerascens Rond.) pozvolilo ustanovit' razmery migratsij ikh, opredelit' mesta rezervatsij, chislennost' populyatsij i izuchit' voprosy pitaniya ukazannykh parazitov vrednykh nasekomykh. Ehtim khe metodom byla ustanovlena dinamika rasprostraneniya karantinnogo ob{sup e}kta kartofel'nogo khuka (Leptinotarsa decemlineota Say), chto pozvolilo poluchit' neobkhodimye dannye dlya provedeniya istrebitel'nykh meropriyatij