Sample records for kannan achan brendan

  1. A Continuation Method for Weakly Kannan Maps

    Directory of Open Access Journals (Sweden)

    Ariza-Ruiz David


    Full Text Available The first continuation method for contractive maps in the setting of a metric space was given by Granas. Later, Frigon extended Granas theorem to the class of weakly contractive maps, and recently Agarwal and O'Regan have given the corresponding result for a certain type of quasicontractions which includes maps of Kannan type. In this note we introduce the concept of weakly Kannan maps and give a fixed point theorem, and then a continuation method, for this class of maps.

  2. Some Similarity between Contractions and Kannan Mappings

    Directory of Open Access Journals (Sweden)

    Tomonari Suzuki


    Full Text Available Contractions are always continuous and Kannan mappings are not necessarily continuous. This is a very big difference between both mappings. However, we know that relaxed both mappings are quite similar. In this paper, we discuss both mappings from a new point of view.

  3. Improved Analysis of Kannan's Shortest Lattice Vector Algorithm

    CERN Document Server

    Hanrot, Guillaume


    The security of lattice-based cryptosystems such as NTRU, GGH and Ajtai-Dwork essentially relies upon the intractability of computing a shortest non-zero lattice vector and a closest lattice vector to a given target vector in high dimensions. The best algorithms for these tasks are due to Kannan, and, though remarkably simple, their complexity estimates have not been improved since more than twenty years. Kannan's algorithm for solving the shortest vector problem is in particular crucial in Schnorr's celebrated block reduction algorithm, on which are based the best known attacks against the lattice-based encryption schemes mentioned above. Understanding precisely Kannan's algorithm is of prime importance for providing meaningful key-sizes. In this paper we improve the complexity analyses of Kannan's algorithms and discuss the possibility of improving the underlying enumeration strategy.

  4. Humour in Prison: Brendan Behan Confesses

    Directory of Open Access Journals (Sweden)

    Enrico Terrinoni


    Full Text Available The essay explores the comical aspects of Behan’s autobiographical writings. It focuses on how humour, especially black humour, often flourishes wherever we find conflicts and contrasts. Humour is always born out of oppositions, and it can be argued that it always functions as an act of resistance to outside tragedy. Brendan Behan, a writer of slum and working class background, is one of the leading Irish prison writers. He is in many ways an exponent of an Irish republican tradition based on the idea of prison endurance. Given Behan’s notoriously flamboyant personality and his own talking gifts, it is not hard to imagine that the worst aspect of prison confinement might have been for him compulsory solitude and silence. His exuberant language and larger-than-life personality can be considered perhaps as a reaction to such partial deprivation of interpersonal relationships during his youth. In this context, where fictional and autobiographical truth are kept apart by an unstable divide increased by the abundance of comical interludes and jokes, the core of the essay analyses the second chapter of Confessions of an Irish Rebel in order to discuss the way in which Behan alternates funny accounts and tragedy in his own autobiographical reports.

  5. Neutrofiilisten granulosyyttien E. coli K12 -kannan fagosytoosi


    Kautonen, Riina


    Tässä työssä tutkittiin bioluminesoivan E. coli K12 pEGFPABCDEamp -kannan viabiliteettiä, mittaamalla bakteerin emittoimaa bioluminesenssia reaaliaikaisesti. Bakteerisolujen tappamiseen käytettiin fagosytoivia neutrofiilisiä granulosyyttejä, jotka eristettiin ihmisen perifeerisestä verestä. Työssä tutkittiin myös veren soluttoman osan seerumin vaikutusta solujen viabiliteettiin ja neutrofiilisten granulosyyttien fagosytoositehokkuuteen. Bakteerisolujen kuolevuutta pyrittiin todistamaan maljaa...

  6. TF type contractive conditions for Kannan and Chatterjea fixed point theorems

    Directory of Open Access Journals (Sweden)

    Mehmet Kir


    Full Text Available In this paper, the notation of TF-contractive conditions are investigated for Kannan and Chatterjea type mappings. It is shown that these mappings have a unique fixed point in complete metric spaces.

  7. 76 FR 77578 - In the Matter of: Brendan Technologies, Inc., CenterStaging Corp., PGMI, Inc., Thermal Energy... (United States)


    ... COMMISSION In the Matter of: Brendan Technologies, Inc., CenterStaging Corp., PGMI, Inc., Thermal Energy... concerning the securities of Brendan Technologies, Inc. because it has not filed any periodic reports since... information concerning the securities of Thermal Energy Storage, Inc. because it has not filed any...

  8. "Where love can have its way": conformity versus resistance in Brendan Kennelly's version of Federico Garcia Lorca's Blood Wedding

    National Research Council Canada - National Science Library

    Persson, Ake


    Considerable critical attention has been paid to Brendan Kennelly's versions of the ancient Greek plays, Antigone, Medea, and The Trojan Women, while his version of Federico Garcia Lorca's Blood Wedding (Bodas de sangre...

  9. “Where love can have its way”: Conformity versus Resistance in Brendan Kennelly’s Version of Federico García Lorca’s Blood Wedding (Bodas de sangre)

    National Research Council Canada - National Science Library

    Åke Persson


    Considerable critical attention has been paid to Brendan Kennelly’s versions of the ancient Greek plays, Antigone, Medea, and The Trojan Women, while his version of Federico García Lorca’s Blood Wedding (Bodas de sangre...

  10. “Where love can have its way”: Conformity versus Resistance in Brendan Kennelly’s Version of Federico García Lorca’s Blood Wedding (Bodas de sangre

    Directory of Open Access Journals (Sweden)

    Åke Persson


    Full Text Available Considerable critical attention has been paid to Brendan Kennelly’s versions of the ancient Greek plays, Antigone, Medea, and The Trojan Women, while his version of Federico García Lorca’s Blood Wedding (Bodas de sangre has largely been ignored. This article examines the ways in which Kennelly’s Blood Wedding challenges fixed gender patterns and traditional social codes. Thus, although set in 1930s rural Spain, the play resonates with issues that have for long been central to Irish identity. Linking Lorca’s artistic concerns to Kennelly’s, and locating the play within areas of great importance to Irish feminism, which questions traditional constructions of womanhood, the article argues that Kennelly’s play proposes a resistance to dominant behaviour, represented as highly restrictive, as well as to the unquestioning conformity to oppressive norms that prevent women, and men, from leading fulfilling lives. In other words, the article suggests that the play ultimately voices the possibility of change, the driving force of which lies in a kind of sisterhood. The play therefore takes part in a questioning and a renegotiation of Irish identity.

  11. St. Brendan's High Support Unit, Mulranny, Westport, Mayo.

    LENUS (Irish Health Repository)

    Walsh, Jennifer M


    The present study is a secondary analysis of the ROLO study, a randomised control trial of a low-glycaemic index (GI) diet in pregnancy to prevent the recurrence of fetal macrosomia. The objectives of the present study were to identify which women are most likely to respond to a low-GI dietary intervention in pregnancy with respect to three outcome measures: birth weight; maternal glucose intolerance; gestational weight gain (GWG). In early pregnancy, 372 women had their mid-upper arm circumference recorded and BMI calculated. Concentrations of glucose, insulin and leptin were measured in early pregnancy and at 28 weeks. At delivery, infant birth weight was recorded and fetal glucose, C-peptide and leptin concentrations were measured in the cord blood. Women who benefited in terms of infant birth weight were shorter, with a lower education level. Those who maintained weight gain within the GWG guidelines were less overweight in both their first and second pregnancies, with no difference being observed in maternal height. Women who at 28 weeks of gestation developed glucose intolerance, despite the low-GI diet, had a higher BMI and higher glucose concentrations in early pregnancy with more insulin resistance. They also had significantly higher-interval pregnancy weight gain. For each analysis, women who responded to the intervention had lower leptin concentrations in early pregnancy than those who did not. These findings suggest that the maternal metabolic environment in early pregnancy is important in determining later risks of excessive weight gain and metabolic disturbance, whereas birth weight is mediated more by genetic factors. It highlights key areas, which warrant further interrogation before future pregnancy intervention studies, in particular, maternal education level and inter-pregnancy weight gain.

  12. Tripled Fixed Point Theorems for Mixed Monotone Kannan Type Contractive Mappings

    Directory of Open Access Journals (Sweden)

    Marin Borcut


    Full Text Available We present new results on the existence and uniqueness of tripled fixed points for nonlinear mappings in partially ordered complete metric spaces that extend the results in the previous works: Berinde and Borcut, 2011, Borcut and Berinde, 2012, and Borcut, 2012. An example and an application to support our new results are also included in the paper.

  13. 'Where Love Can Have Its Way': Conformity versus Resistance in Brendan Kennelly's Version of Federico García Lorca's Blood Wedding (Bodas de sangre)

    National Research Council Canada - National Science Library

    Persson, Åke


    ... García Lorca s Blood Wedding (Bodas de sangre) has largely been ignored. This article examines the ways in which Kennelly s Blood Wedding challenges fixed gender patterns and traditional social codes...

  14. The Impact of Supply Chain Business Processes on Competitive Advantage and Organizational Performance (United States)


    chain has been widely recognized through numerous studies (Cavinato, 1991; Cooper & Ellram, 1993; Tan, Kannan, & Handfield , 1998). "A supply chain is...chain (Tan, Kannan, Handfield , & Ghosh, 1999). Researchers have consistently acknowledged that today’s business environment is no longer reflective of...members of the supply chain" (Tan, Kannan, & Handfield , 1998: 4). Cooper and Ellram (1993) identified three reasons to form supply chains: “1) to

  15. The Relationship Between Key Supply Chain Management Process Implementation, Competitive Advantage and Organizational Performance (United States)


    performance and company performance, Tan, Kannan, and Handfield (1998) employed a survey to collect information on how companies manage three...42-53. Tan, K. C., Kannan, V. R., & Handfield , R. B. (1998). Supply Chain Management: Supplier Performance and Firm Performance. International

  16. Vimkameister Lennart / Tarmo Michelson, Jaan Väljaots, Allar Viivik

    Index Scriptorium Estoniae

    Michelson, Tarmo, 1975-


    Humoorikaid seiku president Lennart Meri elust. Vt. samas: Lennart Meri: "Ma ei ole karsklane ja kannan tublisti."; Endel Lippmaa: eile algas talv; Hans Trass: "President jäi poisikeseks elu lõpuni."

  17. Uganda: Perfection of Post-Conflict Stability or Ticking Time Bomb (United States)


    usual reports. Ms. Anna Kreuss, a German freelance analyst, believes that local militias, formed in response to the huge problem of ghost soldiers... freelance journalist and PhD student), personal interview by authors, Kampala, Uganda, March 24, 2015. 16 Akuma and Achan interview. 17 Ejoyi... freelance journalist and PhD student). Interview by authors. Personal interview. Kampala, Uganda. March 24, 2015. Mapenduzi, Ojara Martin

  18. Proceedings of the ARPA/AFML Review of Progress in Quantitative Nondestructive Evaluation (NDE) (United States)


    fractura anargy varaua aoiatura contant, 2a. Maaaura dynanic «achanical (HOT) raaponaa varaua nolatura contant. Part 3i Data Analyaia and MOT...ductive coll which encircles the specimen, and the acoustic approach whereby the rf energy Is Intro- duced Into the specimen by means of a...thing we hope to do is to Investigate the effects of strain using encircling colls and homogeneous fields. These will be relatively straightforward

  19. Vision-Based Leader/Follower Tracking for Nonholonomic Mobile Robots (United States)


    06/#1 Title: Vision-based Leader/Follower Tracking for Nonholonomic Mobile Robots Authors: Hariprasad Kannan, Vilas. K. Chitrakaran, Darren. M...for Nonholonomic Mobile Robots 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Vision-Based Leader/Follower Tracking for Nonholonomic Mobile Robots Hariprasad Kannan, Vilas K

  20. Fuzzy度量空间上Lipschitz型自映射的公共不动点%Common Fixed Points of Lipschitz-Type Self-Mappings in Fuzzy Metric Spaces

    Institute of Scientific and Technical Information of China (English)

    朱秀娟; 宋明亮



  1. 75 FR 19338 - FM TABLE OF ALLOTMENTS, Milford, Utah (United States)


    ...: Brendan Holland, Esq., Davis Wright Tremaine LLP, 1919 Pennsylvania Avenue, N.W., Suite 200, Washington, D... and by adding Channel 288C at Milford. Federal Communications Commission. John A. Karousos, Assistant...

  2. Modeling Uncertainty and Its Implications in Complex Interdependent Networks (United States)


    dual goal of contributing to advances in reasoning about uncertainty, large-scale text and image data analysis , as well as understanding of complex...Resources & Analysis , OUSD (AT&L) Brendan Fernes, Student, The Cooper Union Published April 30, 2016 Approved for public release; distribution is...Acquisition Resources & Analysis , OUSD (AT&L) Brendan Fernes, Student, The Cooper Union An Optimization-Based Approach to Determine System Requirements

  3. Common fixed point result by using weak commutativity (United States)

    Gupta, Vishal; Mani, Naveen; Devi, Seema


    The main objective of this paper is to establish a common fixed point result for ten mappings satisfying a weaker condition, has been obtained. Our main result generalizes various previously known results such as Kannan, Fisher, Hardy & Rogers and Pande & Dubey.

  4. Global Journal of Computer Science and Technology. Volume 1.2 (United States)

    Dixit, R. K.


    Articles in this issue of "Global Journal of Computer Science and Technology" include: (1) Input Data Processing Techniques in Intrusion Detection Systems--Short Review (Suhair H. Amer and John A. Hamilton, Jr.); (2) Semantic Annotation of Stock Photography for CBIR Using MPEG-7 standards (R. Balasubramani and V. Kannan); (3) An Experimental Study…

  5. New Results on Hashing, Labeling Schemes and Algorithms

    DEFF Research Database (Denmark)

    Knudsen, Mathias Bæk Tejs

    (n) nodes for the family of forests on n nodes. We hereby solve an open problem being raised repeatedly over decades, e.g. in Kannan, Naor, Rudich [STOC'88], Chung [J. of Graph Theory'90], Fraigniaud and Korman [SODA'10]. Joint work with Alstrup and Dahlgaard [FOCS'15]. Even cycle detection: For any...

  6. The Effect of Supply Chain Management Processes on Competitive Advantage and Organizational Performance (United States)


    Kannan, Handfield & Ghosh (1999) attempted to link certain supply chain management practices with firm performance. In particular, they examined the...reduction (Sichinsambwe, 2011). Krause, Handfield , and Scannell (1998) conducted a survey to compare the supplier relationship, 40 percent or more of revenues come from products introduced in the prior year ( Handfield & Nichols, 2002). While the creation of successful

  7. Combined HW/SW Reliability Models. (United States)


    Stone, C. J. (1972). Introduction to Stochastic Processes . New York: Houghton Mifflin. Jelinski, Z. and Moranda, P. (1972). Software reliability...research. Statistical Computer Performance Evaluation, New York: Academic Press, 465-484. Kannan, D. (1979). An Introduction to Stochastic Processes . New

  8. Workshop Polli Talu Loomingulises Keskuses

    Index Scriptorium Estoniae


    MAP Intermedia Performance Collaboration'i (USA) workshop. Brendan McCall (liikumine), N. B. Aldrich (heli) ja Zach Poff (video) workshop tutvustab kolme kunstniku koostööd. Näidatakse ka multimeedia etendust, mis on külaliskunstnikel valminud Polli talus

  9. Browse Title Index - African Journals Online

    African Journals Online (AJOL)

    Items 51 - 100 of 314 ... Vol 10, No 4 (2009), Changing antiretroviral therapy in children, Abstract PDF ... Sighem, Anton Pozniak, Julio Montaner, H Clifford Lane, Brendan Larder ... Vol 7, No 2 (2006), Evaluation of fever of unknown origin before ...

  10. Voyages in Primary Social Studies: A Story-Based Approach. (United States)

    Clarke, Gerry; And Others


    Inspired by Brendan's fantastic sea adventures, this article describes a cooperative university-faculty project to redesign the elementary social studies curriculum in Fredericton, New Brunswick. The new plan employs literature (biography, historical novels, travel accounts, myths and legends, religious stories, poetry, and drama) to enliven study…

  11. Reference: 642 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available nal of biological chemistry Bravo Janis E|Cahoon Edgar B|Chen Ming|Dunn Teresa M|Jaworski Jan G|Lynch Dani...el V|Markham Jonathan E|Mulcahy Brendan J|Richardson Christopher G|Tsegaye Yoseph

  12. Workshop Polli Talu Loomingulises Keskuses

    Index Scriptorium Estoniae


    MAP Intermedia Performance Collaboration'i (USA) workshop. Brendan McCall (liikumine), N. B. Aldrich (heli) ja Zach Poff (video) workshop tutvustab kolme kunstniku koostööd. Näidatakse ka multimeedia etendust, mis on külaliskunstnikel valminud Polli talus

  13. Cold plasma technology close-up (United States)

    This month’s column discusses cold plasma, an emerging technology that has potential applications as an antimicrobial process for fresh and fresh-cut fruits and vegetables, low-moisture foods, and food contact surfaces. Brendan A. Niemira, the coauthor of this month’s column, is the research leader ...

  14. Using a Multiobjective Approach to Balance Mission and Network Goals within a Delay Tolerant Network Topology (United States)


    Proceedings of the 2006 SIGCOMM workshop on Challenged networks. New York, NY, USA: ACM. 23. Cerf, Vincent , RFC 4838 Delay-Tolerant Networking...IEEE Journal of Robotics and Automation, 1986. 2(1): p. 14-23. 44. Burns, Brendan., Oliver Brock, and Brian Neil Levine. MORA routing and capacity

  15. An Application of Quadratic Functions to Australian Government Policy on Funding Schools (United States)

    Nillsen, Rodney


    In the "Sydney Morning Herald" of 23 March 2005, Ross Gittins argued that the funding arrangements for private schools positively encourage parents to move their children from the state system. The then Federal Minister for Education, Dr Brendan Nelson, in a letter to the "Herald" of 25-27 March, responded by saying that 68% of…

  16. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey


    Sivanandy P; Maharajan MK; Rajiah K; Wei TT; Loon TW; Yee LC


    Palanisamy Sivanandy,1 Mari Kannan Maharajan,1 Kingston Rajiah,1 Tan Tyng Wei,2 Tan Wee Loon,2 Lim Chong Yee2 1Department of Pharmacy Practice, School of Pharmacy, 2School of Pharmacy, International Medical University, Wilayah Persekutuan Kuala Lumpur, Malaysia Background: Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much asso...

  17. Derived length for arbitrary topological spaces

    Directory of Open Access Journals (Sweden)

    A. J. Jayanthan


    Full Text Available The notion of derived length is as old as that of ordinal numbers itself. It is also known as the Cantor-Bendixon length. It is defined only for dispersed (that is scattered spaces. In this paper this notion has been extended in a natural way for all topological spaces such that all its pleasing properties are retained. In this process we solve a problem posed by V. Kannan. ([1] Page 158.

  18. Adjacency labeling schemes and induced-universal graphs

    DEFF Research Database (Denmark)

    Alstrup, Stephen; Kaplan, Haim; Thorup, Mikkel


    We show that there exists a graph $G$ with $\\Oh(n)$ nodes, where any forest of $n$ nodes is a node-induced subgraph of $G$. Furthermore, for constant arboricity $k$, the result implies the existence of a graph with $\\Oh(n^k)$ nodes that contains all $n$-node graphs as node-induced subgraphs, matc...... decades, e.g. in Kannan, Naor, Rudich (STOC 1988), Chung (J. of Graph Theory 1990), Fraigniaud and Korman (SODA 2010)....

  19. Toward Development of an Integrated Aerospace Power Doctrine. (United States)


    34 Air University Review, Vol. 37, No. 1: 52-57 (November/December 1985). 104. Russo, Anthony J. Chief, Policy, Doctrine and Strategy, Space Control...MMAS thesis. U.S. Army Command and General Staff College, Fort Leavenworth KS, 1996. 106. Russo, Anthony J. and Eric Millan. Air Force Space Command...Alan and Brendan O’Loghlin, eds. The Decisive Factor: Air Power Doctrine by Air Vice-Marshal H.N. Wrigley . Canberra, Australia: Australian Government

  20. The Prachanda Path and Oglaigh na hEireann: A Comparative Case Study of the Insurgencies in Nepal and Northern Ireland (United States)


    Religious Conflicts in the ‘90s (Amherst, NY: Prometheus Books, 1995), 64. 76Roger MacGinty and John Darby, Guns and Government: The Management of... Prometheus Books, 1995. Heiberg, Marianne, Brendan O’Leary, and John Tirman. eds. Terror, Insurgency, and the State: Ending Protracted Conflicts...History of Nepal. New York, NY: Cambridge University Press, 2005. World Atlas . (accessed 15 March 2008).

  1. The Road to Success in Africa is Paved in Asphalt: Transportation Infrastructure Development in Emerging Economies as a Way to Achieve National Strategic Policy Objectives (United States)


    trade, and communication. These case studies provide examples and precedents of the challenges and benefits that resulted and will be studied in...were paved over their entire length. 10 Around 300 B.C. the Romans discovered sandy volcanic ash near Mount Vesuvius . They combined this ash with...of the requirements for the degree MASTER OF MILITARY ART AND SCIENCE Strategic Studies by BRENDAN JOHN McEVOY, MAJ, US ARMY B.A

  2. Fixed and Best Proximity Points of Cyclic Jointly Accretive and Contractive Self-Mappings

    Directory of Open Access Journals (Sweden)

    M. De la Sen


    Full Text Available p(≥2-cyclic and contractive self-mappings on a set of subsets of a metric space which are simultaneously accretive on the whole metric space are investigated. The joint fulfilment of the p-cyclic contractiveness and accretive properties is formulated as well as potential relationships with cyclic self-mappings in order to be Kannan self-mappings. The existence and uniqueness of best proximity points and fixed points is also investigated as well as some related properties of composed self-mappings from the union of any two adjacent subsets, belonging to the initial set of subsets, to themselves.

  3. Support for the Armor Ceramics symposium at the 40th International Conference on Advanced Ceramics and Composites (United States)


    ICACC-S1-P008-2016. Influence of Curvature on High Velocity Impact of SiC/SiC Composites R. Mansour; M. Kannan; M. Presby; G. Morscher; F. Abdi...end type RBSC radiant tube H. Shin; B. Yun; Y. Kim 5:30 PM-8:00 PM ICACC-S1-P025-2016. The Study on Variables of SiC Granule Prepared from Solar...Cholewa-Kowalska 5:30 PM-8:00 PM ICACC-S9-WW-P067-2016. Ceramic foam filter for the filtration of aluminum with different surface chemistrie C

  4. 蛙泳高肘划水技术分析

    Institute of Scientific and Technical Information of China (English)



    前世界纪录保持者汉森(Brendan Hansen)的蛙泳高肘抱水技术动作。汉森双臂抱水动作的特点是离肘,这样可以使手掌、手腕和前臂充分抱水并产生更大的推进力。在双手划水时.汉森的双臂成弓字形,以推动身体向前移动。

  5. Fermilab science at work

    CERN Document Server

    Six days. Three frontiers. One amazing lab. From 2010 to 2012, a film crew followed a group of scientists at the Department of Energy's Fermilab and filmed them at work and at home. This 40-minute documentary shows the diversity of the people, research and work at Fermilab. Viewers catch a true behind-the-scenes look of the United States' premier particle physics laboratory while scientists explain why their research is important to them and the world. Scientists included: Brendan Casey, Herman White, Craig Hogan, Denton Morris, Mary Convery, Bonnie Fleming, Deborah Harris, Dave Schmitz, Brenna Flaugher and Aron Soha.

  6. Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil


    Cordeiro, Soraia Machado; Neves, Alan B.; Ribeiro, Cássio Tâmara; Petersen, Maya L; Gouveia, Edilane Lins; Guilherme Sousa RIBEIRO; Lôbo, Tatiana Silva; Reis, Joice Neves; Salgado, Kátia M; Reis, Mitermayer Galvão dos; Ko, Albert Icksang


    Agradecemos ao pessoal clínico, laboratorial e administrativo do Hospital Couto Maia, especialmente a Ana Maria Maia e Neide Oliveira Silva; Steve Copolla e Ricardo Martinez Pinheiro pela assistência na coleta de dados e processamento; a Maviany Mota pela assistência com as análises de laboratório; Brendan Flannery e Luciano K. Silva pela assistência com análises estatísticas, Edgar Lessa Crusoé, Orgalí Marques, Neci Ivo Ramos e Nilda Lúcia Nunes (Bahia) por fornecer informações sobre noti...

  7. Modern challenges in therapeutic protein production. (United States)

    Chiverton, Lesley Margaret


    The Modern Challenges in Therapeutic Protein Production conference hosted 44 delegates from the UK and Germany and was organized by EuroSciCon. The aim of the meeting was to look at the challenges that currently face the production of therapeutic proteins and to attempt to demystify some of the novel approaches and new technologies that are being developed and could have applications in this area. The Chair, Brendan Fish (GlaxoSmithKline, Barnard Castle, UK), gave a detailed introduction to the conference and finished with a summation at the end.

  8. College students' knowledge about fetal alcohol spectrum disorder. (United States)

    Brems, Christiane; Johnson, Mark E; Metzger, Jesse S; Dewane, Sarah L


    Fetal Alcohol Spectrum Disorders (FASDs) are the leading known preventable birth defects in North America. Knowledge surveys about FASD have been conducted with various health and allied healthcare providers and have proven useful in identifying gaps in knowledge and differences among provider groups to support prevention efforts. To date, no research has been conducted exploring FASD knowledge among college students. This study explored FASD knowledge in a sample of college students, a group at particularly high risk for alcohol-exposed pregnancies. Findings are compared to professionals in several healthcare and affiliated professional groups who were previously surveyed with the same FASD-related items. Surveys from 1,035 college students at a northwestern university were analyzed. Included with the ACHA-National College Health Assessment II were questions regarding FASD. College students' knowledge was compared with that of professionals in key healthcare and affiliated positions to define their relative awareness of FASD risk. Overall, findings revealed adequate FASD knowledge among college students. Although minor differences emerged when comparing students and professionals' responses, most respondent groups answered with an 85% accuracy rate or higher. College students demonstrated adequate knowledgeable about FASD. Future research must explore whether such knowledge translates into lower risk behavior and consequent reduction in alcohol-exposed pregnancies.

  9. Fixed points for alpha-psi contractive mappings with an application to quadratic integral equations

    Directory of Open Access Journals (Sweden)

    Bessem Samet


    Full Text Available Recently, Samet et al [24] introduced the concept of alpha-psi contractive mappings and studied the existence of fixed points for such mappings. In this article, we prove three fixed point theorems for this class of operators in complete metric spaces. Our results extend the results in [24] and well known fixed point theorems due to Banach, Kannan, Chatterjea, Zamfirescu, Berinde, Suzuki, Ciric, Nieto, Lopez, and many others. We prove that alpha-psi contractions unify large classes of contractive type operators, whose fixed points can be obtained by means of the Picard iteration. Finally, we utilize our results to discuss the existence and uniqueness of solutions to a class of quadratic integral equations.

  10. Evolutionary Trees can be Learned in Polynomial-Time in the Two-State General Markov Model

    DEFF Research Database (Denmark)

    Cryan, Mary; Goldberg, Leslie Ann; Goldberg, Paul Wilfred


    The j-state general Markov model of evolution (due to Steel) is a stochastic model concerned with the evolution of strings over an alphabet of size j. In particular, the two-state general Markov model of evolution generalizes the well-known Cavender-Farris-Neyman model of evolution by removing......--Farris--Neyman model provided that the target tree satisfies the additional restriction that all pairs of leaves have a sufficiently high probability of being the same. We show how to remove both restrictions and thereby obtain the first polynomial-time PAC-learning algorithm (in the sense of Kearns et al...... the symmetry restriction (which requires that the probability that a "0" turns into a "1" along an edge is the same as the probability that a "1" turns into a "0" along the edge). Farach and Kannan showed how to probably approximately correct (PAC)-learn Markov evolutionary trees in the Cavender...

  11. Fixed point theorems for mappings satisfying contractive conditions of integral type and applications

    Directory of Open Access Journals (Sweden)

    Kang Shin


    Full Text Available Abstract In this paper, the existence, uniqueness and iterative approximations of fixed points for contractive mappings of integral type in complete metric spaces are established. As applications, the existence, uniqueness and iterative approximations of solutions for a class of functional equations arising in dynamic programming are discussed. The results presented in this paper extend and improve essentially the results of Branciari (A fixed point theorem for mappings satisfying a general contractive condition of integral type. Int. J. Math. Math. Sci. 29, 531-536, 2002, Kannan (Some results on fixed points. Bull. Calcutta Math. Soc. 60, 71-76, 1968 and several known results. Four concrete examples involving the contractive mappings of integral type with uncountably many points are constructed. 2010 Mathematics Subject Classfication: 54H25, 47H10, 49L20, 49L99, 90C39

  12. Evolutionary Trees can be Learned in Polynomial-Time in the Two-State General Markov Model

    DEFF Research Database (Denmark)

    Cryan, Mary; Goldberg, Leslie Ann; Goldberg, Paul Wilfred


    The j-state general Markov model of evolution (due to Steel) is a stochastic model concerned with the evolution of strings over an alphabet of size j. In particular, the two-state general Markov model of evolution generalizes the well-known Cavender-Farris-Neyman model of evolution by removing...... the symmetry restriction (which requires that the probability that a "0" turns into a "1" along an edge is the same as the probability that a "1" turns into a "0" along the edge). Farach and Kannan showed how to probably approximately correct (PAC)-learn Markov evolutionary trees in the Cavender......--Farris--Neyman model provided that the target tree satisfies the additional restriction that all pairs of leaves have a sufficiently high probability of being the same. We show how to remove both restrictions and thereby obtain the first polynomial-time PAC-learning algorithm (in the sense of Kearns et al...

  13. Nanomedicine in cerebral palsy

    Directory of Open Access Journals (Sweden)

    Balakrishnan B


    Full Text Available Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Department of Ophthalmology, Center for Nanomedicine, Johns Hopkins University, Baltimore, MD, USA Abstract: Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the developing brain that occurs either in utero or soon after birth can result in the motor, sensory, and cognitive deficits seen in cerebral palsy. Although the etiologies for cerebral palsy are variable, neuroinflammation plays a key role in the pathophysiology of the brain injury irrespective of the etiology. Currently, there is no effective cure for cerebral palsy. Nanomedicine offers a new frontier in the development of therapies for prevention and treatment of brain injury resulting in cerebral palsy. Nanomaterials such as dendrimers provide opportunities for the targeted delivery of multiple drugs that can mitigate several pathways involved in injury and can be delivered specifically to the cells that are responsible for neuroinflammation and injury. These materials also offer the opportunity to deliver agents that would promote repair and regeneration in the brain, resulting not only in attenuation of injury, but also enabling normal growth. In this review, the current advances in nanotechnology for treatment of brain injury are discussed with specific relevance to cerebral palsy. Future directions that would facilitate clinical translation in neonates and children are also addressed. Keywords: dendrimer, cerebral palsy, neuroinflammation, nanoparticle, neonatal brain injury, G4OH-PAMAM

  14. Offshore oil: costs and benefits. [Pamphlet

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, T.; Byrne, B.; Cousteau, J.Y.; Haynes, H.; Hughes, R.


    This pamphlet provides the edited transcript of a Round Table that concluded AEI's two-day conference on the impact of offshore oil, held at Los Angeles, California, in March 1975. The participants were Governor Brendan Byrne of New Jersey, representing the eastern coastal states governors, Captain Jacques-Yves Cousteau for the environmentalists, Chairman of the Board H. J. Haynes of Standard Oil of California for the oil companies, and Assistant Secretary Royston Hughes, representing the Department of the Interior and the administration generally. The moderator was Mayor Tom Bradley of Los Angeles. Regulations regarding the leasing of offshore sites and the impact of energy conservation on energy supplies are summarized. (MCW)

  15. Lixivaptan – an evidence-based review of its clinical potential in the treatment of hyponatremia

    Directory of Open Access Journals (Sweden)

    Bowman BT


    Full Text Available Brendan T Bowman, Mitchell H Rosner Division of Nephrology, University of Virginia Health System, Charlottesville, VA, USA Abstract: Hyponatremia is the most common electrolyte abnormality seen in clinical practice. Most cases of euvolemic or hypervolemic hyponatremia involve arginine vasopressin (AVP. AVP leads to a concentrated urine and negative free water clearance. Given this primary role of AVP, antagonizing its effect through blockade of its receptor in the distal tubule is an attractive therapeutic target. Lixivaptan is a newer, non-peptide, vasopressin type 2 receptor antagonist. Recent studies have demonstrated efficacy. This review summarizes the clinical pharmacology and data for this new agent. Keywords: vasopressin, hyponatremia, heart failure, lixivaptan, therapy, outcomes

  16. Determinants of adjacency matrices of graphs

    Directory of Open Access Journals (Sweden)

    Alireza Abdollahi


    Full Text Available We study the set of all determinants of adjacency matrices of graphs with a given number of vertices. Using Brendan McKay's data base of small graphs, determinants of graphs with at most $9$ vertices are computed so that the number of non-isomorphic graphs with given vertices whose determinants are all equal to a number is exhibited in a table. Using an idea of M. Newman, it is proved that if $G$ is a graph with $n$ vertices and ${d_1,dots,d_n}$ is the set of vertex degrees of $G$, then $gcd(2m,d^2$ divides the determinant of the adjacency matrix of $G$, where $d=gcd(d_1,dots,d_n$. Possible determinants of adjacency matrices of graphs with exactly two cycles are obtained.

  17. Agonist-induced hump current production in heterologously-expressed human α4β2-nicotinic acetylcholine receptors

    Institute of Scientific and Technical Information of China (English)

    Qiang LIE; Ke-wei YU; Yong-chang CHANG; Ronald J LUKAS; Jie WU


    Aim:To characterize the functional and pharmacological features of agonist-induced hump currents in human α4β2-nicotinic acetylcholine receptors (nAChR).Methods:Whole-cell and outside-out patch recordings were performed using human α4β2-nAChR heterologously expressed in stably-transfected,native nAChR-null subclonal human epithelial 1 (SH-EP1) cells.RT-PCR was used to test the mRNA expression of transfected nAChR.Homology modeling and ace-tylcholine (Ach) docking were applied to show the possible Ach-binding site in the channel pore.Results:The rapid exposure of 10 mmol/L Ach induced an inward current with a decline from peak to steady-state.However,after the re-moval of Ach,an additional inward current,called "hump" current,reoccurred.The ability of agonists to produce these hump currents cannot be easily explained based on drug size,charge,acute potency,or actions as full or partial agonists.Hump currents were associated with a rebound increase in whole-cell conductance,and they had voltage dependence-like peak currents induced by agonist action.Hump currents blocked by the α4β2-nAChR antagonist dihydro-β-erythroidine were reduced when α4β2-nAChR were desensitized,and were more pronounced in the absence of external Ca2+.Outside-out single-channel recordings demon-strated that compared to 1 μmol/L nicotine,100 μmol/L nicotine reduced channel current amplitude,shortened the channel mean open time,and prolonged the channel mean closed time,supporting an agonist-induced open-channel block before hump current production.A docking model also simulated the agonist-binding site in the channel pore.Conclusion:These results support the hypoth-esis that hump currents reflect a rapid release of agonists from the α4β2-nAChR channel pore and a rapid recovery from desensitized α4β2-nAChR.

  18. Matching nuts and bolts in O(n log n) time

    Energy Technology Data Exchange (ETDEWEB)

    Komlos, J. [Rutgers Univ., Piscataway, NJ (United States); Ma, Yuan [Stanford Univ., CA (United States); Szemeredi, E. [Rutgers Univ., Piscataway, NJ (United States)


    Given a set of n nuts of distinct widths and a set of n bolts such that each nut corresponds to a unique bolt of the same width, how should we match every nut with its corresponding bolt by comparing nuts with bolts (no comparison is allowed between two nuts or between two bolts)? The problem can be naturally viewed as a variant of the classic sorting problem as follows. Given two lists of n numbers each such that one list is a permutation of the other, how should we sort the lists by comparisons only between numbers in different lists? We give an O(n log n)-time deterministic algorithm for the problem. This is optimal up to a constant factor and answers an open question posed by Alon, Blum, Fiat, Kannan, Naor, and Ostrovsky. Moreover, when copies of nuts and bolts are allowed, our algorithm runs in optimal O(log n) time on n processors in Valiant`s parallel comparison tree model. Our algorithm is based on the AKS sorting algorithm with substantial modifications.

  19. Approximate Counting of Graphical Realizations. (United States)

    Erdős, Péter L; Kiss, Sándor Z; Miklós, István; Soukup, Lajos


    In 1999 Kannan, Tetali and Vempala proposed a MCMC method to uniformly sample all possible realizations of a given graphical degree sequence and conjectured its rapidly mixing nature. Recently their conjecture was proved affirmative for regular graphs (by Cooper, Dyer and Greenhill, 2007), for regular directed graphs (by Greenhill, 2011) and for half-regular bipartite graphs (by Miklós, Erdős and Soukup, 2013). Several heuristics on counting the number of possible realizations exist (via sampling processes), and while they work well in practice, so far no approximation guarantees exist for such an approach. This paper is the first to develop a method for counting realizations with provable approximation guarantee. In fact, we solve a slightly more general problem; besides the graphical degree sequence a small set of forbidden edges is also given. We show that for the general problem (which contains the Greenhill problem and the Miklós, Erdős and Soukup problem as special cases) the derived MCMC process is rapidly mixing. Further, we show that this new problem is self-reducible therefore it provides a fully polynomial randomized approximation scheme (a.k.a. FPRAS) for counting of all realizations.

  20. Approximate Counting of Graphical Realizations.

    Directory of Open Access Journals (Sweden)

    Péter L Erdős

    Full Text Available In 1999 Kannan, Tetali and Vempala proposed a MCMC method to uniformly sample all possible realizations of a given graphical degree sequence and conjectured its rapidly mixing nature. Recently their conjecture was proved affirmative for regular graphs (by Cooper, Dyer and Greenhill, 2007, for regular directed graphs (by Greenhill, 2011 and for half-regular bipartite graphs (by Miklós, Erdős and Soukup, 2013. Several heuristics on counting the number of possible realizations exist (via sampling processes, and while they work well in practice, so far no approximation guarantees exist for such an approach. This paper is the first to develop a method for counting realizations with provable approximation guarantee. In fact, we solve a slightly more general problem; besides the graphical degree sequence a small set of forbidden edges is also given. We show that for the general problem (which contains the Greenhill problem and the Miklós, Erdős and Soukup problem as special cases the derived MCMC process is rapidly mixing. Further, we show that this new problem is self-reducible therefore it provides a fully polynomial randomized approximation scheme (a.k.a. FPRAS for counting of all realizations.

  1. The Triangle Closure is a Polyhedron

    CERN Document Server

    Basu, Amitabh; Köppe, Matthias


    Recently, cutting planes derived from maximal lattice-free convex sets have been studied intensively by the integer programming community. An important question in this research area has been to decide whether the closures associated with certain families of lattice-free sets are polyhedra. For a long time, the only result known was the celebrated theorem of Cook, Kannan and Schrijver who showed that the split closure is a polyhedron. Although some fairly general results were obtained by Andersen, Louveaux and Weismantel [An analysis of mixed integer linear sets based on lattice point free convex sets, Math. Oper. Res. 35, (2010) pp. 233--256], some basic questions have remained unresolved. For example, maximal lattice-free triangles are the natural family to study beyond the family of splits and it has been a standing open problem to decide whether the triangle closure is a polyhedron. In this paper, we resolve this by showing that the triangle closure is indeed a polyhedron, and its number of facets can be ...


    Institute of Scientific and Technical Information of China (English)

    吕义忠; 高晓波


    复杂性研究中的一个重点问题是非一致复杂类的测度问题.Aldman已经证明了BPPP/poly,而Kannan证明了EXPSPACEP/poly.本文提出逼近接受的概念,用来讨论K-团问题的非一致复杂性.本文中使用了模型论的方法,证明了K-团问题P/poly,co-NPP/poly和NPP/poly.因此,本文解决了Karp和Lipton(K-L)提出的开问题:"NPP/poly吗?"%A central problem in the study of complexity is the measure of nonuniform complexity classes. BPPP/poly has been proved by Aldman, and EXPSPACEP/poly by Kannan. We propose the definition of approximate acceptance with which we discuss the nonuniform complexity of the K sized complete subgraph problem. The method of modal theory is used and the K sized complete subgraph problemP/poly, co-NPP/poly and NPP/poly is proved. This paper solves the Karp-Lipton′s open problem: "NPP/poly?"

  3. Acknowledgement to Reviewers

    Directory of Open Access Journals (Sweden)

    Editorial Office


    Full Text Available Acknowledgement to ReviewersThe editorial board of International Journal of Cancer Therapy and Oncology (IJCTO wishes to acknowledge the help of reviewers who have generously contributed their valuable time and efforts during the period September 2013–October 2014 in the appraisal of manuscripts submitted to the IJCTO. Abdulhamid Chaikh (FranceAlok Singh (USAAnamika Basu (USAAnish Banerjee (IndiaAntonella Fogliata (SwitzerlandArun Oinam (IndiaBirendra Kumar Rout (IndiaBrindha Subramanian (AustraliaCharles Bloch (USACharles Shang (USAChee-Wai Cheng (USAChih-Yao Cheng (USADaniel Bailey (USADanijela Scepanovic (SlovakiaErsalan Hernandez (USAEsmaeel Ghasroddashti (CanadaH Sudahar (IndiaHe Wang (USAKanan Jassal (IndiaLanchun Lu (USALei Guo (USALeonardo da Silva Boia (USALuiz Antonio Ribeiro da Rosa (BrasilMaria Chan (USAMing Yan (USAMohamed Fawzy (EgyptMohammad Rafiqul Islam (USANilseia Aparecida Barbosa (BrasilNita Nair (IndiaPanayiotis Mavroidis (USAPaul Sijens (NetherlandsPaulo Roberto Fonseca (BrasilPei-Hsin Cheng (USAPrabhakar Ramachandran (AustraliaPradip Maiti (IndiaPratik Kumar (IndiaQinghui Zhang (USAQiyong Fan (USARadu Alin Vasilache (RomaniaRajesh Thiyagarajan (IndiaRanjita Shegokar (GermanyRick Sims (New ZelandSara Bresciani (ItalySaurabh Varshney (IndiaShyam Pokhrel (USASunder Goyal (IndiaSupriya Chopra (IndiaSuresh Rana (USAToks Yerokun (USATulika Seth (USAV. Kannan (IndiaWaldemar Ulmer (GermanyWaqas Shuaib (USAXiang-Ming Ding (USAYida Hu (USAYong Chen (USAYu Wang (USAYuanming Feng (USAYulin Song (USA

  4. The calculation of information and organismal complexity

    Directory of Open Access Journals (Sweden)

    Xu Cunshuan


    Full Text Available Abstract Background It is difficult to measure precisely the phenotypic complexity of living organisms. Here we propose a method to calculate the minimal amount of genomic information needed to construct organism (effective information as a measure of organismal complexity, by using permutation and combination formulas and Shannon's information concept. Results The results demonstrate that the calculated information correlates quite well with the intuitive organismal phenotypic complexity defined by traditional taxonomy and evolutionary theory. From viruses to human beings, the effective information gradually increases, from thousands of bits to hundreds of millions of bits. The simpler the organism is, the less the information; the more complex the organism, the more the information. About 13% of human genome is estimated as effective information or functional sequence. Conclusions The effective information can be used as a quantitative measure of phenotypic complexity of living organisms and also as an estimate of functional fraction of genome. Reviewers This article was reviewed by Dr. Lavanya Kannan (nominated by Dr. Arcady Mushegian, Dr. Chao Chen, and Dr. ED Rietman (nominated by Dr. Marc Vidal.

  5. An Optimal Labeling Scheme for Ancestry Queries

    CERN Document Server

    Fraigniaud, Pierre


    An ancestry labeling scheme assigns labels (bit strings) to the nodes of rooted trees such that ancestry queries between any two nodes in a tree can be answered merely by looking at their corresponding labels. The quality of an ancestry labeling scheme is measured by its label size, that is the maximal number of bits in a label of a tree node. In addition to its theoretical appeal, the design of efficient ancestry labeling schemes is motivated by applications in web search engines. For this purpose, even small improvements in the label size are important. In fact, the literature about this topic is interested in the exact label size rather than just its order of magnitude. As a result, following the proposal of a simple interval-based ancestry scheme with label size $2\\log_2 n$ bits (Kannan et al., STOC '88), a considerable amount of work was devoted to improve the bound on the size of a label. The current state of the art upper bound is $\\log_2 n + O(\\sqrt{\\log n})$ bits (Abiteboul et al., SODA '02) which is...

  6. Current trends in the treatment of hepatic encephalopathy

    Directory of Open Access Journals (Sweden)

    Mohamad Rasm Al Sibae


    Full Text Available Mohamad Rasm Al Sibae, Brendan M McGuireDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USAAbstract: Hepatic encephalopathy (HE is a common reversible neuropsychiatric syndrome associated with chronic and acute liver dysfunction and significant morbidity and mortality. Although a clear pathogenesis is yet to be determined, elevated ammonia in the serum and central nervous system are the mainstay for pathogenesis and treatment. Management includes early diagnosis and prompt treatment of precipitating factors (infection, gastrointestinal bleeding, electrolyte disturbances, hepatocellular carcinoma, dehydration, hypotension, and use of benzodiazepines, psychoactive drugs, and/or alcohol. Clinical trials have established the efficacy of lactulose and lactitol enemas in the treatment of acute hepatic encephalopathy. Extensive clinical experience has demonstrated the efficacy of oral lactulose and lactitol with the goal of two to three soft bowel movements a day for the treatment of chronic HE. However, lactulose and lactitol have significant gastrointestinal side effects. For patients unable to tolerate lactulose or lactitol or who still have persistent chronic HE with lactulose or lactitol, neomycin, metronidazole and rifaximin are second-line agents. More recent data supports the benefits of rifaximin used solely and as an additional agent with fewer side effects than neomycin or metronidazole. Newer therapies being investigated in humans with clinical promise include nitazoxanide, the molecular adsorbent recirculating system (MARS, L-ornithine phenylacetate, sodium benzoate, and/or sodium phenylacetate and Kremezin® (AST-120.Keywords: hepatic encephalopathy, liver dysfunction, lactulose, lactitol

  7. Brauer groups and obstruction problems moduli spaces and arithmetic

    CERN Document Server

    Hassett, Brendan; Várilly-Alvarado, Anthony; Viray, Bianca


    The contributions in this book explore various contexts in which the derived category of coherent sheaves on a variety determines some of its arithmetic. This setting provides new geometric tools for interpreting elements of the Brauer group. With a view towards future arithmetic applications, the book extends a number of powerful tools for analyzing rational points on elliptic curves, e.g., isogenies among curves, torsion points, modular curves, and the resulting descent techniques, as well as higher-dimensional varieties like K3 surfaces. Inspired by the rapid recent advances in our understanding of K3 surfaces, the book is intended to foster cross-pollination between the fields of complex algebraic geometry and number theory. Contributors: · Nicolas Addington · Benjamin Antieau · Kenneth Ascher · Asher Auel · Fedor Bogomolov · Jean-Louis Colliot-Thélène · Krishna Dasaratha · Brendan Hassett · Colin Ingalls · Martí Lahoz · Emanuele Macrì · Kelly McKinnie · Andrew Obus · Ekin Ozman · Raman...

  8. Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers

    Directory of Open Access Journals (Sweden)

    Brendan Doyle


    Full Text Available Brendan Doyle, David R Holmes JrDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USAAbstract: The success of drug-eluting stents in preventing restenosis has shifted the focus of new stent development toward enhancing long term safety and efficacy of these devices, while simultaneously eliminating the need for indefinite dual antiplatelet therapy. A technical advance fulfilling these aims would hold tremendous potential to reduce morbidity, mortality and economic costs associated with the percutaneous treatment of coronary artery disease. An attractive approach is the use of bioabsorbable stent designs. These may include stents with different bioabsorbable drugs, bioabsorbable polymers or even bioabsorbable metallic backbones. A device that could achieve excellent acute and long-term results, but disappear completely within months (thereby avoiding the need for prolonged dual antiplatelet therapy, would be a tremendous advance. Too good to be true? We explore here the scientific rationale and prospects for success with this exciting concept.Keywords: percutaneous coronary intervention, biodegradable, bioabsorbable, polymer, stent

  9. Twelve weeks of BodyBalance® training improved balance and functional task performance in middle-aged and older adults

    Directory of Open Access Journals (Sweden)

    Nicholson VP


    Full Text Available Vaughan P Nicholson, Mark R McKean, Brendan J Burkett School of Health and Sport Sciences, University of the Sunshine Coast, Sunshine Coast, QLD, Australia Purpose: The purpose of the study was to evaluate the effect of BodyBalance® training on balance, functional task performance, fear of falling, and health-related quality of life in adults aged over 55 years.Participants and methods: A total of 28 healthy, active adults aged 66±5 years completed the randomized controlled trial. Balance, functional task performance, fear of falling, and self-reported quality of life were assessed at baseline and after 12 weeks. Participants either undertook two sessions of BodyBalance per week for 12 weeks (n=15 or continued with their normal activities (n=13.Results: Significant group-by-time interactions were found for the timed up and go (P=0.038, 30-second chair stand (P=0.037, and mediolateral center-of-pressure range in narrow stance with eyes closed (P=0.017. There were no significant effects on fear of falling or self-reported quality of life.Conclusion: Twelve weeks of BodyBalance training is effective at improving certain balance and functional based tasks in healthy older adults. Keywords: postural control, yoga, tai chi, center of pressure, exercise

  10. 幸福、欢乐、悲伤与爱

    Institute of Scientific and Technical Information of China (English)


    一个新颖而独特的剧本,前所未见的类型……《我呼吸的空气》The Air I Breathe导演:杰赫·李Jieho Lee主演:布兰登·费舍Brendan Fraser、弗里斯特·惠特克Forest Whitaker、凯文·贝肯Kevin Bacon、莎拉·米歇尔·盖拉Sarah Michelle Gellar、胡凯莉Kelly Hu类型:剧情/爱情/犯罪首映:2008年1月25日出品:Inferno发行公司故事:传说当人的生命碎裂后只留下四种情感:幸福、欢乐、悲伤与爱。本片用互相穿插的几个人命运,揭示了人生的真谛:一个商人把他的全部身家都押在一场赛马上,一个黑帮分子预见了自己的未来,一个明星被黑帮老大所骗,一个医生必须去解救他所爱的人……

  11. Targeted treatment of advanced and metastatic breast cancer with lapatinib

    Directory of Open Access Journals (Sweden)

    Brendan Corkery


    Full Text Available Brendan Corkery1,2, Norma O’Donovan2, John Crown1,21St. Vincent’s University Hospital, Dublin, Ireland; 2National Institute for Cellular Biotechnology, Dublin City University, Dublin, IrelandAbstract: Improved molecular understanding of breast cancer in recent years has led to the discovery of important drug targets such as HER-2 and EGFR. Lapatinib is a potent dual inhibitor of HER-2 and EGFR. Preclinical and phase I studies have shown activity with lapatinib in a number of cancers, including breast cancer, and the drug is well tolerated. The main known drug interactions are with paclitaxel and irinotecan. The most significant side-effects of lapatinib are diarrhea and adverse skin events. Rates of cardiotoxicity compare favorably with trastuzumab, a monoclonal antibody against HER-2. This paper focuses on lapatinib in advanced and metastatic breast cancer, which remains an important therapeutic challenge. Phase II and III studies show activity as monotherapy, and in combination with chemotherapy or hormonal agents. Results from these studies suggest that the main benefit from lapatinib is in the HER-2 positive breast cancer population. Combinations of lapatinib and trastuzumab are also being studied and show encouraging results, particularly in trastuzumab-refractory metastatic breast cancer. Lapatinib may have a specific role in treating HER-2 positive CNS metastases. The role of lapatinib as neoadjuvant therapy and in early breast cancer is also being evaluated.Keywords: HER-2, EGFR, erbB, lapatinib, Tykerb®, tyrosine kinase

  12. Kaks grenaderi : [luuletused] / Heinrich Heine ; tlk. August Sang, Ellen Niit, Karl Eduard Sööt, Gustav Wulff-Õis, Minni Nurme, Märt Pukits, Anna Haava, Debora Vaarandi, Jaan Kross, August Annist, Jaan Kärner, Martin Lipp, Jakob Tamm, Eduard Lud

    Index Scriptorium Estoniae

    Heine, Heinrich, 1797-1856


    Sisu: Kaks grenaderi ; Ärasõit ; Emale ; "See oli lahkel lehekuul..." ; "Mu silmaveest sigivad lilled..." ; "Su nägu armast, ilusat..." ; "Sääl kõrgel liikumata..." ; "Sind kannan laulu tiivul..." ; "Õrn lootoslill end varjab..." ; "Maailm on juhm, ja juhmimaks..." ; "Kui teaksid lilled aasal..." ; Lüüriline intermetso ; "Maast särava päikese poole..." ; "On suvi nüüd, õhetav suvi..." ; "Näen unes sind ma öösiti..." ; "Puil sügistuul raputab oksi..." ; "Kord mu hämarasse ellu..." ; "Mis peaks küll tähendama..." ; "Sa, kaunis kaluritütar..." ; "Kuu tõusnud kulla karva..." ; "Kuu kui hiiglapomerants..." ; "Öö ligines... Õhtu eha sees..." ; "Ma kaugel horisondil..." ; "Öö vaikuses on linn kõik vaga..." ; "Küll aastad tulevad, kaovad..." ; "Kuu paistis kurvalt - nii nägin und..." ; "Ilm arvab armuvalus..." ; "See, kes esmakordselt armub..." ; "Suveõhtu hämardumas..." ; "Öö on teel... Silm ette vaatab..." ; "Kus on nüüd see kullakene..." ; Mäeidüll ; "Kui sa valge puu all istud..." ; "Jälle süda unest ärkab..." ; "Nägin haldjaid kihutamas..." ; "Ülal tähed kuldseil jalgel..." ; Seraphine : "Öö on mustad tiivad laotand..." ; "Nii vaikselt viirab merepind..." ; "Hämar öö on üle mere..." ; "Kui oleks ta kullast, nii sädeleb..." ; Hortense : "Me tänavanurgal seisime ; "Ei kaua petnud mind see õnn..." ; Klarisse : "On hilja, mis sa naerad mulle..." ; Anno 1839 ; Kus? ; Saladus ; Laatsarus : Surija ; Targad tähed ; Saksamaa ; Elusõit. Eluloolisi andmeid autori kohta lk. 459

  13. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey

    Directory of Open Access Journals (Sweden)

    Sivanandy P


    Full Text Available Palanisamy Sivanandy,1 Mari Kannan Maharajan,1 Kingston Rajiah,1 Tan Tyng Wei,2 Tan Wee Loon,2 Lim Chong Yee2 1Department of Pharmacy Practice, School of Pharmacy, 2School of Pharmacy, International Medical University, Wilayah Persekutuan Kuala Lumpur, Malaysia Background: Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use.Objective: To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia.Methods: A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted.Results: The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of “staff training and skills” were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup.Conclusion: The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety. Keywords

  14. Kaks grenaderi : [luuletused] / Heinrich Heine ; tlk. August Sang, Ellen Niit, Karl Eduard Sööt, Gustav Wulff-Õis, Minni Nurme, Märt Pukits, Anna Haava, Debora Vaarandi, Jaan Kross, August Annist, Jaan Kärner, Martin Lipp, Jakob Tamm, Eduard Lud

    Index Scriptorium Estoniae

    Heine, Heinrich, 1797-1856


    Sisu: Kaks grenaderi ; Ärasõit ; Emale ; "See oli lahkel lehekuul..." ; "Mu silmaveest sigivad lilled..." ; "Su nägu armast, ilusat..." ; "Sääl kõrgel liikumata..." ; "Sind kannan laulu tiivul..." ; "Õrn lootoslill end varjab..." ; "Maailm on juhm, ja juhmimaks..." ; "Kui teaksid lilled aasal..." ; Lüüriline intermetso ; "Maast särava päikese poole..." ; "On suvi nüüd, õhetav suvi..." ; "Näen unes sind ma öösiti..." ; "Puil sügistuul raputab oksi..." ; "Kord mu hämarasse ellu..." ; "Mis peaks küll tähendama..." ; "Sa, kaunis kaluritütar..." ; "Kuu tõusnud kulla karva..." ; "Kuu kui hiiglapomerants..." ; "Öö ligines... Õhtu eha sees..." ; "Ma kaugel horisondil..." ; "Öö vaikuses on linn kõik vaga..." ; "Küll aastad tulevad, kaovad..." ; "Kuu paistis kurvalt - nii nägin und..." ; "Ilm arvab armuvalus..." ; "See, kes esmakordselt armub..." ; "Suveõhtu hämardumas..." ; "Öö on teel... Silm ette vaatab..." ; "Kus on nüüd see kullakene..." ; Mäeidüll ; "Kui sa valge puu all istud..." ; "Jälle süda unest ärkab..." ; "Nägin haldjaid kihutamas..." ; "Ülal tähed kuldseil jalgel..." ; Seraphine : "Öö on mustad tiivad laotand..." ; "Nii vaikselt viirab merepind..." ; "Hämar öö on üle mere..." ; "Kui oleks ta kullast, nii sädeleb..." ; Hortense : "Me tänavanurgal seisime ; "Ei kaua petnud mind see õnn..." ; Klarisse : "On hilja, mis sa naerad mulle..." ; Anno 1839 ; Kus? ; Saladus ; Laatsarus : Surija ; Targad tähed ; Saksamaa ; Elusõit. Eluloolisi andmeid autori kohta lk. 459

  15. A Four-Star Lightweight (United States)

    Kohler, Susanna


    An important part of exoplanet studies is the attempt to understand how planets and solar systems form. New measurements of the lowest-mass quadruple star system ever discovered are now confirming an intriguing theory: in addition to other channels, large gas planets may form in the same way that stars do.Formation ChannelsExoplanets have been found in an enormous variety of configurations, from hot Jupiters only 0.01 AU away from their host star, to planetary-mass companions that orbit at a whopping distance of 1,000 AU.Formation of these gas giants could occur via a number of different theorized pathways, such as growth from rocky cores close to host star, or fragmentation from instabilities far out in the protoplanetary disk. But given that the line between giant planets and brown dwarfs is somewhat fuzzy, another theory has come under consideration as well: could gas giants form out of the collapse and fragmentation of a molecular cloud, in the same way that stars form?In a recent study, Brendan Bowler and Lynne Hillenbrand (California Institute of Technology) argue that one star system, 2M0441+2301 AabBab, might actually be evidence that this channel works. 2M0441+2301 AabBab is a young (less than 3 million years old) quadruple system in the Taurus star-forming region, previously identified through imaging. Since photometry alone isnt enough to be sure of the masses of the components, Bowler and Hillenbrand used the OSIRIS instrument on the Keck I telescope to obtain the first resolved spectra of each component of this system, verifying the systems intriguing properties.Pair of PairsNear-IR spectra of 2M0441+2301 Aa, Ab, Ba, and Bb. The insets shows the unresolved 2MASS image of the system and the Keck/NIRC2 images of each binary subsystem. Click for a better look! [BowlerHillenbrand 2015]2M0441+2301 AabBab is whats known as a hierarchical quadruple system: it consists of a pair of close-binary star systems that orbit each other at an enormous distance of at

  16. Synovial fluid sedimentation in the immobile patient: a commentary on modern septic arthritis and the addition of a new variable confounding diagnosis

    Directory of Open Access Journals (Sweden)

    Cunningham G


    Full Text Available Gregory Cunningham,1 Brendan Ricciardo21Royal Perth Hospital, Perth, Western Australia, Australia; 2Bunbury Regional Hospital, Bunbury, Western Australia, AustraliaAbstract: Septic arthritis is a serious cause of morbidity and mortality. Despite recent advances, monoarticular and polyarticular septic arthritis (SA have a mortality rate of approximately 11% and 30%, respectively. SA has a 40% risk of permanent loss of joint function. Diagnosis of SA is difficult, given that no rapidly available individual test proves 100% sensitive or 100% specific. There are no previous reports on the phenomenon of synovial fluid sedimentation in an immobile patient, although the occurrence has been identified in vitro. This commentary also presents an extended report of a patient who had been immobile and supine for 24 hours before her right knee was aspirated and treated for septic arthritis. Due to her immobilization, the synovial fluid had settled. The color and opacity of the sequential aliquots from one arthrocentesis was noted to change from light straw-colored, to thick opaque purulent material. Laboratory reports showed increasing white cell counts (WCCs, from 2.6 × 109 to 78 × 109 between the sequential samples. This demonstrates a newly identified phenomenon of sedimentation. This might have led to a diagnostic difficulty, had the knee not been fully aspirated. Aspiration serves as a diagnostic tool, because it collects a sample, but it also serves as a treatment measure, because it removes purulent material. Complete aspiration of the joint should be performed for full therapeutic benefit and to avoid the potential diagnostic confusion of a falsely low WCC due to this newly identified phenomenon of synovial fluid sedimentation in the immobile patient.Keywords: septic arthritis, inflammatory arthritis, joint, sedimentation, orthopedic

  17. Reflection and person-centredness in practice development

    Directory of Open Access Journals (Sweden)

    Kylie Smith


    Full Text Available In 2003, Kim Manley and Brendan McCormack wrote that practice development needed to be underpinned by critical social science that would enable ‘sustainable change through practitioner enlightenment, empowerment and emancipation and an associated culture’ (Manley and McCormack, 2003, p 22. In this article they drew on the work of Habermas to argue that technical and practical knowledge is essential to human practice, but is of limited value in achieving social transformation. Transformation occurs at the level of emancipatory knowledge, where the practitioner becomes aware of the power embedded in social relations and uses this critical awareness to transcend immediate self-interest and work towards systemic change. This requires an unflinching and honest assessment of values and beliefs, and a questioning of the taken-for-granted assumptions (and the sometimes hidden power that underpin practice (Manley and McCormack, 2003, p 26. This is especially the case in healthcare systems and cultures like nursing, which have a long history of uneasy power relations between practitioners, and between practitioners and patients (Holmes and Gastaldo, 2002; Perron et al., 2005. Practice development was therefore envisioned as an emancipatory approach to transforming the nature of nursing work and the cultures within which that work occurs (Manley et al., 2014. This has been particularly important in the move to person-centred care, which is not just a technical approach to health service delivery but an authentic moral and ethical recognition of the rights of the individual. Enabling health practitioners to engage with their practice at this deep, socio-political level requires a truly emancipatory approach, supported by methods and tools that facilitate transformative learning and critical self-awareness. Reflective practice, or critical reflection, is one of those tools.

  18. Computational Investigations of Rovibrational Quenching of HD due to Collisions in the Interstellar Medium (United States)

    Goodman Veazey, Clark; Wan, Yier; Yang, Benhui H.; Stancil, P.


    When conducting an examination of distant astronomical objects, scientists rely on measurements derived from astronomical observations of these objects, which are primarily collected using spectroscopy. In order to interpret spectroscopic data collected on astronomical objects, it is necessary to have a background of accurate dynamical information on interstellar molecules at one’s disposal. Seeing as most of the observable infrared radiation in the universe is emitted by molecules excited by collisional processes in the interstellar gas, generating accurate data on the rate of molecular collisions is of salient interest to astronomical endeavors.The collisional system we will be focusing on here is He-HD, an atom-diatom system in which He collides with HD. We are primarily interested in the cooling capabilities of this system, as these species are predicted to have played an important role in the formation of primordial stars, which emerged from a background composed solely of Hydrogen, Helium, and their compounds. HD is being investigated because it has a finite dipole moment and is hence a powerful radiator, and He due to its relative abundance in the early universe. Using a hybrid OpenMP/MPI adaption (vrrm) of a public-domain scattering package, cross sections for He-HD collisions are computed for a swathe of both rotational and vibrational states across a range of relevant kinetic energies, then integrated to produce rate coefficients. Due to the vast computational requirements for performing these operations, the use of high-powered computational resources is necessary.The work of CV was funded by a UGA Center for Undergraduate Research Opportunities award. We thank the University of Georgia GACRC and NERSC at Lawrence-Berkeley for computational resources and Brendan McLaughlin for assistance.

  19. How can clinician-educator training programs be optimized to match clinician motivations and concerns?

    Directory of Open Access Journals (Sweden)

    McCullough B


    Full Text Available Brendan McCullough, Gregory E Marton, Christopher J Ramnanan Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada Background: Several medical schools have implemented programs aimed at supporting clinician-educators with formal mentoring, training, and experience in undergraduate medical teaching. However, consensus program design has yet to be established, and the effectiveness of these programs in terms of producing quality clinician-educator teaching remains unclear. The goal of this study was to review the literature to identify motivations and perceived barriers to clinician-educators, which in turn will improve clinician-educator training programs to better align with clinician-educator needs and concerns. Methods: Review of medical education literature using the terms “attitudes”, “motivations”, “physicians”, “teaching”, and “undergraduate medical education” resulted in identification of key themes revealing the primary motivations and barriers involved in physicians teaching undergraduate medical students. Results: A synthesis of articles revealed that physicians are primarily motivated to teach undergraduate students for intrinsic reasons. To a lesser extent, physicians are motivated to teach for extrinsic reasons, such as rewards or recognition. The key barriers deterring physicians from teaching medical students included: decreased productivity, lack of compensation, increased length of the working day, patient concerns/ethical issues, and lack of confidence in their own ability. Conclusion: Our findings suggest that optimization of clinician-educator training programs should address, amongst other factors, time management concerns, appropriate academic recognition for teaching service, and confidence in teaching ability. Addressing these issues may increase the retention of clinicians who are active and proficient in medical education. Keywords: clinician-educators, teaching, undergraduate medical

  20. Structural perspective on enzymatic halogenation. (United States)

    Blasiak, Leah C; Drennan, Catherine L


    Simple halogen substituents frequently afford key structural features that account for the potency and selectivity of natural products, including antibiotics and hormones. For example, when a single chlorine atom on the antibiotic vancomycin is replaced by hydrogen, the resulting antibacterial activity decreases by up to 70% ( Harris , C. M. ; Kannan , R. ; Kopecka , H. ; Harris , T. M. J. Am. Chem. Soc. 1985 , 107 , 6652 - 6658 ). This Account analyzes how structure underlies mechanism in halogenases, the molecular machines designed by nature to incorporate halogens into diverse substrates. Traditional synthetic methods of integrating halogens into complex molecules are often complicated by a lack of specificity and regioselectivity. Nature, however, has developed a variety of elegant mechanisms for halogenating specific substrates with both regio- and stereoselectivity. An improved understanding of the biological routes toward halogenation could lead to the development of novel synthetic methods for the creation of new compounds with enhanced functions. Already, researchers have co-opted a fluorinase from the microorganism Streptomyces cattleya to produce (18)F-labeled molecules for use in positron emission tomography (PET) ( Deng , H. ; Cobb , S. L. ; Gee , A. D. ; Lockhart , A. ; Martarello , L. ; McGlinchey , R. P. ; O'Hagan , D. ; Onega , M. Chem. Commun. 2006 , 652 - 654 ). Therefore, the discovery and characterization of naturally occurring enzymatic halogenation mechanisms has become an active area of research. The catalogue of known halogenating enzymes has expanded from the familiar haloperoxidases to include oxygen-dependent enzymes and fluorinases. Recently, the discovery of a nucleophilic halogenase that catalyzes chlorinations has expanded the repertoire of biological halogenation chemistry ( Dong , C. ; Huang , F. ; Deng , H. ; Schaffrath , C. ; Spencer , J. B. ; O'Hagan , D. ; Naismith , J. H. Nature 2004 , 427 , 561 - 565 ). Structural

  1. Ambulatory and home blood pressure monitoring: gaps between clinical guidelines and clinical practice in Singapore

    Directory of Open Access Journals (Sweden)

    Setia S


    Full Text Available Sajita Setia,1 Kannan Subramaniam,2 Boon Wee Teo,3 Jam Chin Tay4 1Chief Medical Office, Medical Affairs, Pfizer Pte Ltd, Singapore; 2Global Medical Affairs, Asia Pacific Region, Pfizer Australia, West Ryde, New South Wales, Australia; 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4Department of General Medicine, Tan Tock Seng Hospital, Singapore Purpose: Out-of-office blood pressure (BP measurements (home blood pressure monitoring [HBPM] and ambulatory blood pressure monitoring [ABPM] provide important additional information for effective hypertension detection and management decisions. Therefore, out-of-office BP measurement is now recommended by several international guidelines. This study evaluated the practice and uptake of HBPM and ABPM among physicians from Singapore. Materials and methods: A sample of physicians from Singapore was surveyed between 8 September and 5 October 2016. Those included were in public or private practice had been practicing for ≥3 years, directly cared for patients ≥70% of the time, and treated ≥30 patients for hypertension per month. The questionnaire covered six main categories: general BP management, BP variability (BPV awareness/diagnosis, HBPM, ABPM, BPV management, and associated training needs. Results: Sixty physicians (30 general practitioners, 20 cardiologists, and 10 nephrologists were included (77% male, 85% aged 31–60 years, and mean 22-year practice. Physicians recommended HBPM and ABPM to 81% and 27% of hypertensive patients, respectively. HBPM was most often used to monitor antihypertensive therapy (88% of physicians and 97% thought that ABPM was useful for providing information on BPV. HBPM instructions often differed from current guideline recommendations in terms of frequency, number of measurements, and timing. The proportion of consultation time devoted to discussing HBPM and BPV was one-quarter or less for 73% of physicians, and

  2. Some physiotherapy treatments may relieve menstrual pain in women with primary dysmenorrhea: a systematic review

    Directory of Open Access Journals (Sweden)

    Priya Kannan


    Full Text Available Question: In women with primary dysmenorrhoea, what is the effect of physiotherapeutic interventions compared to control (either no treatment or placebo/sham on pain and quality of life? Design: Systematic review of randomised trials with meta-analysis. Participants: Women with primary dysmenorrhea. Intervention: Any form of physiotherapy treatment. Outcome measures: The primary outcome was menstrual pain intensity and the secondary outcome was quality of life. Results: The search yielded 222 citations. Of these, 11 were eligible randomised trials and were included in the review. Meta-analysis revealed statistically significant reductions in pain severity on a 0–10 scale from acupuncture (weighted mean difference 2.3, 95% CI 1.6 to 2.9 and acupressure (weighted mean difference 1.4, 95% CI 0.8 to 1.9, when compared to a control group receiving no treatment. However, these are likely to be placebo effects because when the control groups in acupuncture/acupressure trials received a sham instead of no treatment, pain severity did not significantly differ between the groups. Significant reductions in pain intensity on a 0–10 scale were noted in individual trials of heat (by 1.8, 95% CI 0.9 to 2.7, transcutaneous electrical nerve stimulation (2.3, 95% CI 0.03 to 4.2, and yoga (3.2, 95% CI 2.2 to 4.2. Meta-analysis of two trials of spinal manipulation showed no significant reduction in pain. None of the included studies measured quality of life. Conclusion: Physiotherapists could consider using heat, transcutaneous electrical nerve stimulation, and yoga in the management of primary dysmenorrhea. While benefits were also identified for acupuncture and acupressure in no-treatment controlled trials, the absence of significant effects in sham-controlled trials suggests these effects are mainly attributable to placebo effects. [Kannan P, Claydon LS (2014 Some physiotherapy treatments may relieve menstrual pain in women with primary dysmenorrhea: a

  3. Gum arabic-coated radioactive gold nanoparticles cause no short-term local or systemic toxicity in the clinically relevant canine model of prostate cancer

    Directory of Open Access Journals (Sweden)

    Axiak-Bechtel SM


    Full Text Available Sandra M Axiak-Bechtel,1 Anandhi Upendran,2,3 Jimmy C Lattimer,1 James Kelsey,3,4 Cathy S Cutler,4 Kim A Selting,1 Jeffrey N Bryan,1 Carolyn J Henry,1,5 Evan Boote,6 Deborah J Tate,1 Margaret E Bryan,7 Kattesh V Katti,3,8 Raghuraman Kannan3,8 1Department of Veterinary Medicine and Surgery, 2Department of Physics, University of Missouri, Columbia, MO, USA; 3Nanoparticle Biochem, Inc., and Shasun-NBI LLC, Columbia, MO, USA; 4Missouri University Research Reactor, 5Department of Internal Medicine, University of Missouri, Columbia, MO, USA; 6Spectrum Health, Grand Rapids, MI, USA; 7Department of Statistics, 8Department of Radiology, University of Missouri, Columbia, MO, USA Introduction: Gum arabic-coated radioactive gold nanoparticles (GA-198AuNPs offer ­several advantages over traditional brachytherapy in the treatment of prostate cancer, including homogenous dose distribution and higher dose-rate irradiation. Our objective was to determine the short-term safety profile of GA-198AuNPs injected intralesionally. We proposed that a single treatment of GA-198AuNPs would be safe with minimal-to-no evidence of systemic or local toxicity.Methods: Nine dogs with spontaneously occurring prostatic cancer were treated. Injections were performed with ultrasound or computerized tomography guidance. Complete blood counts, chemistry panels, and urinalyses were performed at weekly intervals for 1 month and imaging was repeated 4 weeks postinjection. Planar scintigraphic images were obtained within 30 minutes of injection.Results: No statistically significant difference was found in any hematologic or biochemical parameter studied, nor was any evidence of tumor swelling or abscessation found in eight dogs with repeat imaging; one dog died secondary to urethral obstruction 12 days following injection. At 30 minutes postinjection, an average of 53% of injected dose in seven dogs was retained in the prostate, with loss of remaining activity in the bladder and

  4. Economic analysis and budget impact of clostridial collagenase ointment compared with medicinal honey for treatment of pressure ulcers in the US

    Directory of Open Access Journals (Sweden)

    Mearns ES


    Full Text Available Elizabeth S Mearns,1 Michael Liang,1 Brendan L Limone,1 Adrienne M Gilligan,1 Jeffrey D Miller,1 Kathleen D Schaum,2 Curtis R Waycaster2 1Truven Health Analytics, an IBM Company, Cambridge, MA, USA; 2Smith & Nephew, Inc., Fort Worth, TX, USA Objectives: Pressure ulcer (PU treatment poses significant clinical and economic challenges to health-care systems. The aim of this study was to assess the cost-effectiveness and budget impact of enzymatic debridement with clostridial collagenase ointment (CCO compared with autolytic debridement with medicinal honey (MH for PU treatment from a US payer/Medicare perspective in the hospital outpatient department setting.Methods: A cost-effectiveness analysis using a Markov model was developed using a 1-week cycle length across a 1-year time horizon. The three health states were inflammation/senescence, granulation/proliferation (ie, patients achieving 100% granulation, and epithelialization. Data sources included the US Wound Registry, Medicare fee schedules, and other published clinical and cost studies about PU treatment.Results: In the base case analysis over a 1-year time horizon, CCO was the economically dominant strategy (ie, simultaneously conferring greater benefit at less cost. Patients treated with CCO experienced 22.7 quality-adjusted life weeks (QALWs at a cost of $6,161 over 1 year, whereas MH patients experienced 21.9 QALWs at a cost of $7,149. Patients treated with CCO achieved 11.5 granulation weeks and 6.0 epithelization weeks compared with 10.6 and 4.4 weeks for MH, respectively. The number of clinic visits was 40.1 for CCO vs 43.4 for MH, and the number of debridements was 12.3 for CCO compared with 17.6 for MH. Probabilistic sensitivity analyses determined CCO dominant in 72% of 10,000 iterations and cost-effective in 91%, assuming a benchmark willingness-to-pay threshold of $50,000/quality-adjusted life year ($962/QALW. The budget impact analysis showed that for every 1% of patients

  5. The Time Is Now: Bioethics and LGBT Issues. (United States)

    Powell, Tia; Foglia, Mary Beth


    Our goal in producing this special issue is to encourage our colleagues to incorporate topics related to LGBT populations into bioethics curricula and scholarship. Bioethics has only rarely examined the ways in which law and medicine have defined, regulated, and often oppressed sexual minorities. This is an error on the part of bioethics. Medicine and law have served in the past as society's enforcement arm toward sexual minorities, in ways that robbed many people of their dignity. We feel that bioethics has an obligation to discuss that history and to help us as a society take responsibility for it. We can address only a small number of topics in this special issue of the Hastings Center Report, and we selected topics we believe will stimulate discourse. Andrew Solomon offers an elegant overview of the challenges that bioethics faces in articulating a solid basis for LGBT rights. Timothy F. Murphy asks whether bioethics still faces issues related to lesbian, gay, and bisexual people, given the deletion of homosexuality as a disease and the progress toward same-sex marriage. Jamie Lindemann Nelson's essay addresses the search for identity for transgender persons and the role of science in that search. Two articles, those by Brendan S. Abel and by Jack Drescher and Jack Pula, take up the complex issue of medical treatment for children who reject their assigned birth gender. Celia B. Fisher and Brian Mustanski address the special challenges of engaging LGBT youth in research, balancing the need for better information about this vulnerable group against the existing restrictions on research involving children. Tia Powell and Edward Stein consider the merits of legal bans on psychotherapies intended to change sexual orientation, particularly in the light of current research on orientation. Mary Beth Foglia and Karen I. Fredricksen-Goldsen highlight health disparities and resilience among LGBT older adults and then discuss the role of nonconscious bias in perpetuating

  6. Simulating Halos with the Caterpillar Project (United States)

    Kohler, Susanna


    the Caterpillar Project, detailed in a recently published paper led by Brendan Griffen (Massachusetts Institute of Technology). The Caterpillar Project was designed to simulate 70 Milky-Way-size halos (quadrupling the total number of halos that have been simulated in the past!) at a high mass resolution (10,000 solar masses per particle) and time resolution (5 Myr per snapshot). The project is extremely computationally intense, requiring 14 million CPU hours and 700 TB of data storage!Mass evolution of the first 24 Caterpillar halos (selected to be Milky-Way-size at z=0). The inset panel shows the mass evolution normalized by the halo mass at z=0, demonstrating the highly varied evolution these different halos undergo. [Griffen et al. 2016]In this first study, the Griffen and collaboratorsshow the end states for the first 24 halos of the project, evolved from a large redshift to today (z=0). They use these initialresults to demonstrate the integrity of their data and the utility of their methods, which include new halo-finding techniques that recover more substructure within each halo.The first results from the Caterpillar Project are already enough to show clear general trends, such as the highly variable paths the different halos take as they merge, accrete, and evolve, as well as how different their ends states can be. Statistically examining the evolution of these halos is an importantnext step in providinginsight intothe origin and evolution of the Milky Way, and helping us to understand how our galaxy differs from other galaxies of similar mass. Keep an eye out for future results from this project!BonusCheck out this video (make sure to watch in HD!) of how the first 24 Milky-Way-like halos from the Caterpillar simulations form. Seeingthese halos evolve simultaneously is an awesome way to identifythe similarities and differences between them.CitationBrendan F. Griffen et al 2016 ApJ 818 10. doi:10.3847/0004-637X/818/1/10

  7. Multiproxy reconstruction of tropical Pacific Holocene temperature gradients and water column structure (United States)

    Arbuszewski, J. A.; Oppo, D.; Huang, K.; Dubois, N.; Galy, V.; Mohtadi, M.; Herbert, T.; Rosenthal, Y.; Linsley, B. K.


    consider records from organic (sterol abundances) and inorganic proxies (Mg/Ca and δ18O of 3 planktonic foraminiferal species, % G. bulloides) to reconstruct zonal tropical Pacific (sub)surface temperature and stratification gradients over the Holocene. A benefit of using this approach is that it enables us to combine the strengths of each individual proxy to derive more robust records. We will compare our records with published paleoproxy and model studies in the Pacific and Indo-Pacific regions. Armed with this information, we aim to better understand mean state changes in the tropical Pacific over the Holocene. 1 Ropelewski, C. F. & Halpert, M. S. Monthly Weather Review 115, 1606-1626 (1987). 2 Collins, M. et al. Nature Geoscience 3, doi: 10.1038/NGEO1868 (2010). 3 Koutavas, A., Lynch-Steiglitz, J., Marchitto, T. & Sachs, J. Science 297, 226-230 (2002). 4 Moy, C. M., Seltzer, G. O., Rodbell, D. T. & Anderson, D. M. Nature 420, 162-165 (2002). 5 Conroy, J. L., Overpeck, J. T., Cole, J. E., Shanahan, T. M. & Steinitz-Kannan, M. Quaternary Science Reviews 27, 1166-1180 (2008). 6 Makou, M. C., Eglinton, T. I., Oppo, D. W. & Hughen, K. A. Geology 38, 43-46 (2010). 7 Karnauskas, K., Smerdon, J., Seager, R. & Gonzalez-Rouco, J. Journal of Climate, doi: 10.1178/JCLI-D-1111-00421.00421 (2012 (in press)). 8 Clement, A., Seager, R. & Cane, M. Paleoceanography 14, 441-456 (2000).

  8. Diagnostic Classification of Normal Persons and Cancer Patients by Using Neural Network Based on Trace Metal Contents in Serum Samples

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Zhuo-yong


    [1]Miatto, O. , Casaril, M. , Gabriell, G. B. , et al. , Cancer, 55, 774(1985)[2]Margalioth, E. J., Udassin, R., Maor, J. , et al. , Cancer, 56, 856(1986)[3]Xu, B., Chinese Journal of Tumor, 12, 512(1990)[4]Jayadeep, A. , Raveendran, P. K. , Kannan, S. , et al. , J. Exp. Clin. Cancer Res. , 16, 295 (1997)[5]Sattar, N. , Scott, H. R. , McMillan, D. C. , et al. , Nutr. Cancer, 28, 308(1997)[6]Koksoy, C. , Kavas, G. O. , Akcil, E. , et al. , Breast Cancer Res. Treat. , 45, 1(1997)[7]Leung,P. L. , Huang, H. M. , Biol. Trace Elem. Res. , 57, 19(1997)[8]Antila, E. , Mussalo-Rauhamaa, H. , Kantola, M. , et al. , Sci. Total Environ. , 186, 251(1996)[9]Tariq, M. A. , Qama-un-Nisa, Fatima, A. , Sci. Total Environ. , 175, 43(1995)[10]Martin-Lagos, F. , Navarro-Alarcon, M. , Terres-Martos, C. , et al. , Sci. Total Environ. , 204, 27(1997)[11]Poo, J. L. , Romero, R. R. , Robles, J. A. , et al. , Arch. Med. Res. , 28, 259(1997)[12]Magalova, T., Bella, V. , Brtkova, A. , et al. , Neoplasma, 46, 100(1999)[13]Ferrigno, D. , Buccheri, G. , Camilla, T. , et al. , Archives for Chest Disease, 54, 204(1999)[14]Huang, Y. L. , Sheu, J. Y. , Lin, T. H. , Clinical Biochem. , 32, 131(1999)[15]Songchitsomboon, S. , Komindr, S. , Komindr, A. , et al. , J. Med. Assoc. Thai, 82, 701(1999)[16]Mason, R. P. , Cancer, 85, 2 093(1999)[17]Wargovith, M. J. , Ed. Moon T. E. , Micozz M. S. , Calcium, Vitamin D and the Prevention of Gastrointestinal Cancer, in Nutrition and Cancer Prevention, Marcel Dekker Inc. , New York, 1989:291[18]Leung, P. L. , Li, X. L. , Li, Z. X. , et al. , Biol. Trace Elem. Res. , 42, 1(1994)[19]Jing, X. ,Han, C., Cancer Research on Prevention and Treatment, 25, 186(1998)[20]Huang, Y. , Li, J. , Carcinogenesis, Teratogenesis and Mutagenesis, 10, 123(1998)[21]Wang, X. , Zhu, E. ,Yan, X. , et al. , Acta Chimica Sinica, 51, 1 094(1993)[22]Wan, T. , Qin, S. , Zhuang, S. , et al. , Rock and Mineral

  9. Päevad on laused : [luulekava] / Ene Mihkelson ; koost. Arne Merilai

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-


    Sisu: "Ühel väga pimedal väga lagedal väljal kus must taevas..." ; "Luuletaja elas pimedas toas ja ootas nägemusi..." ; "Ma lähen ma tulen ma olen ma seisan alati paigal..." ; "Miks meeldib mulle tetraeeder just karjamaal..." ; "Igavene on ilmaköis..." ; "Elu ongi jumalagajätt väljamõeldud..." ; "Kui olin saanud neljaseks Nii väga kiitis..." ; "Meid oli üks tüdruk Me rääkisime..." ; "Olin kaua endaga ma isekeskis õppisin..." ; "Varemed ei põle need vajuvad mulda..." ; "Juustes kasvab valgus..." ; "Küll tahaks vabaneda valeluulest..." ; "Ta armastus on surm..." ; "Minult on küsitud, kas ma saan keerulisemalt ja ma olen öelnud..." ; "Ta haridus oli lünklik, omandatud peamiselt iseõppimise..." ; "Valge kala ujub läbi metsa..." ; "Sinagi kuuled vist kuidas..." ; "Raual on raua kõla..." ; "Need köied ripuvad..." ; "Ärkasin kolmekümne seitsme aastasena..." ; "Üksteise sisse on minek asjadel ja elul..." ; "Mitte metsade vahelt vaid põldude äärest..." ; "Hämarusest tulevad ja hämarusse lähevad näod..." ; "Ta jutustas, mida nägi, ja see oli nii, nagu oleksid kõik..." ; "Mu päevatöö on read mu päevatöö on vari..." ; "Minevik on müüa..." ; "Üks kauge küla tappis ennast ise..." ; "Suur must auk on küla sees..." ; "Rooste on rahulik Rooste..." ; "Mees kes pianisti sõrmeluid ükshaaval murdnud..." ; "Kellele tema oma hinge müüs..." ; "Tuletan sulle meelde et oleme palju..." ; "Sest tema oli barbar mitte päritolu tõttu, vabast tahtest..." ; "Kui veel reagi kirjutad..." ; "Sügavale on taevas mind matnud..." ; "Kes ta siis ikkagi oli: inimene eikuskilt, miks ta ei..." ; "Me läheme ürgsele maale seal pilvede kodu..." ; "Kannan sõelaga aega..." ; "Jumal sina oled näinud mu kujutluste..." ; "Tõstsin kivi mille all elas vähk..." ; "See hingelõpp see võppumine..." ; "Risti alla pandi sinu keha..." ; "Igal ajal ööl on musta värvi..." ; "Vahest elaski kord mees kelle..." ; "Vast ainult üks meil on see päris hull

  10. Micromorphology of two prehistoric ritual burials from Yemen, and considerations on methodological aspects of sampling the burial matrix - work in progress (United States)

    Usai, Maria-Raimonda; Brothwell, Don; Buckley, Stephen; Ai-Thour, Kalid; Canti, Matthew


    micromorphological level. Layer 1 included mineral, bone, plant and soil-like fragments, with leaf and woody tissue, including vascular parts and seeds. Layer 9 included plant tissue, hair, seeds and some fly puparia. Comments Layering of the burial matrix in the Yemeni burials was unexpected and the burial matrix in one case was very clearly not the result of natural soil forming processes within the rock crevice. In Burial Site A the hard upper capping contained uric acid-rich deposits embedding organic tissue. This sample could possibly represent an intentional ‘plaster layer' including plant, hair and seed fragments. The abundant cholesterol confirms an animal/human origin within the matrix of Layers 10 and 22, and the stanol and bile acid distributions unequivocally confirm a human origin, despite the lack of any physical human remains. Microprobe analysis indicated that the hard cup of Burial 1 contained K, Si, Al, Cu, Mg, S, Fe and Na with amounts fluctuating relatively to depth. No special significance can be placed on the differences. This study calls attention to a neglected aspect of burial archaeology: grave infillings can no longer be assumed to be simply the return of material removed for the burial, but may be influenced by other factors. Through micromorphology, decomposed wood, shroud or other textiles or skins and hair can be detected and, if local rituals influenced the way materials were returned into the grave, then this also deserves investigation. A new ERC-funded project (Title: "Interred with their bones", acronym: "InterArChive") tackles these issues (please see separate poster). Acknowledgments We thank Allan Hall, Brendan Keely, Trevor Dransfield, Andrea Vacca and Cagliari University

  11. Hypoparathyroidism as the first manifestation of Kearns-sayre syndrome. A case report

    Directory of Open Access Journals (Sweden)



    DNA deletion disorder. Lancet 2004;364(9434:592–6.Bosbach S, Kornblum C, Schröder R, Wagner M. Executive and visuospatial deficits in patients with chronic progressive external ophthalmoplegia and Kearns-Sayer syndrome. Brain 2003;126(Pt 5:1231-40.Berenberg RA, Pellock JM, DiMauro S, Schotland DL, Bonilla E, Eastwood A, et al. Lumping or splitting? “Ophthalmoplegia-plus” or Kearns-Sayer syndrome? Ann Neurol 1977;1(1:37-54.Welzing L, von Kleist-Retzow JC, Kribs A, Eifinger F, Huenseler C, Sreeram N. Rapid development of life threatening complete atrioventricular block in Kearns-Sayer syndrome. Eur J Pediatr 2009;168(6:757-9.Berio A, Piazzi A. Kearns-Sayer syndrome with GH deficiency. Pediatr Med Chir 2000;22:43-6.Schmiedel J, Jackson S, Schäfer J, Reichmann H. Mitochondrial cytopathies. J Neurol 2003;250(3:267-77.Chu BC, Terae S, Takahashi C, Kikuchi Y, Miyasaka K, Abe S, et al. MRI of the brain in the Kearns-Sayer syndrome: report of four cases and a review. Neuroradiology 1999;41(10:759-64.Altunbaşak S, Bingöl G, Ozbarlas N, Akçören Z, Hergüner O. Kearns-Sayer syndrome. A case report. Turk J Pediatr 1998;40(2:255-9.Chawla S, Coku J, Forbes T, Kannan S. Kearns-Sayer syndrome presenting as complete heart block. Pediatr Cardiol 2008;29(3:659-62.Gregoratos G, Abrams J, Epstein AE, Freedman RA, Hayes DL, Hlatky MA, et al. ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/ AHA/NASPE Committee to Update the 1998 Pacemaker Guidelines. Circulation 2002;106(16:2145-61.Basu AP, Posner E, McFarland R, Turnbull DM. Kearnsayre syndrome. Medscape reference. Feb 4, 2010.

  12. Optimisation of logistics processes of energy grass collection (United States)

    Bányai, Tamás.


    Fund. References [1] P. R. Daniel: The Economics of Harvesting and Transporting Corn Stover for Conversion to Fuel Ethanol: A Case Study for Minnesota. University of Minnesota, Department of Applied Economics. 2006. [2] T. G. Douglas, J. Brendan, D. Erin & V.-D. Becca: Energy and Chemicals from Native Grasses: Production, Transportation and Processing Technologies Considered in the Northern Great Plains. University of Minnesota, Department of Applied Economics. 2006. [3] Homepage of energygrass.

  13. A Very Cool Pair of Brown Dwarfs (United States)


    determine the distance to the brown dwarfs. More information This research was presented in a paper, "CFBDSIR J1458+1013B: A Very Cold (>T10) Brown Dwarf in a Binary System", Liu et al. to appear in the Astrophysical Journal. The team is composed of Michael C. Liu (Institute for Astronomy [IfA], University of Hawaii, USA), Philippe Delorme (Institut de planétologie et d'astrophysique de Grenoble, CNRS/Université Joseph Fourier, France [IPAG]), Trent J. Dupuy (Harvard-Smithsonian Center for Astrophysics, Cambridge, USA), Brendan P. Bowler (IfA), Loic Albert (Canada-France-Hawaii Telescope Corporation, Hawaii, USA), Etienne Artigau (Université de Montréal, Canada), Celine Reylé (Observatoire de Besançon, France), Thierry Forveille (IPAG) and Xavier Delfosse (IPAG). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 15 countries: Austria, Belgium, Brazil, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  14. Autologous Bone Marrow Stem Cells in Spinal Cord Injury; Our Experience in Clinical Studies, Animal Studies, Obstacles faced and steps for future

    Directory of Open Access Journals (Sweden)

    Ayyappan S


    , Santos M. Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration? Neurosci Lett. 2006 Haro J, Zurita M, Ayllón L, Vaquero J. Detection of 111.In-oxine-labeled bone marrow stromal cells after intravenous or intralesional administration inchronic paraplegic rats. Neurosci Lett. 2005 Mar4.Yano S, Kuroda S, Lee JB, Shichinohe H, Seki T, Ikeda J, Nishimura G, Hida K, Tamura M, Iwasaki Y. In vivo fluorescence tracking of bone marrow stromal cells transplanted into pneumatic injury model of rat spinal cord. J Neurotrauma.2005 Aug5.Ravikumar R, Narayanan S, Baskar S, SenthilNagarajan R, Abraham S. Autologous Stem Cell Injection for Spinal Cord Injury- A Clinical Study from India. PASRM 2007-0046.Justin William B, Ayyappan S, DhanaJayaRao G, Pushkinraj H, Kannan TA , Sureshkumar R, Manjunath S, Murugan P, Srinivasan V, Abraham S. Intralesional Application of Autologous Bone Marrow Stem Cells with Scaffold in Canine for Spinal Cord Injury. PASRM, IV annual symposium , 2009.7.Yasuda H, Kuroda S, Shichinohe H, Kamei S, Kawamura R, Iwasaki Y. Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats. J Neurosurg. 2010 ;112(2:336-44. 8.Abraham et al. Stem cell Clinical trials Session. Stem cell Global blue Print Conference (21-22 May2010 Toronto, Canada

  15. PREFACE: Dielectrics 2009: Measurement Analysis and Applications (United States)

    Vaughan, Alun; Williams, Graham


    The conference Dielectrics 2009: Measurements, Analysis and Applications represents a significant milestone in the evolution of dielectrics research in the UK. It is reasonable to state that the academic study of dielectrics has led to many fundamental advances and that dielectric materials underpin the modern world in devices ranging from field effect transistors, which operate at extremely high fields, albeit low voltages, to the high voltage plants that provide the energy that powers our economy. The origins of the Dielectrics Group of the Institute of Physics (IOP), which organized this conference, can be traced directly back to the early 1960s, when Professor Mansel Davies was conducting research into the dielectric relaxation behaviour of polar liquids and solids at The Edward Davies Chemical Laboratories of the University College of Wales, Aberystwyth. He was already well-known internationally for his studies of molecular structure and bonding of small molecules, using infra-red-spectroscopy, and of the physical properties of hydrogen-bonded liquids and solids, using thermodynamic methods. Dielectric spectroscopy was a fairly new area for him and he realized that opportunities for scientists in the UK to gather together and discuss their research in this developing area of physical chemistry/chemical physics were very limited. He conceived the idea of forming a Dielectrics Discussion Group (DDG), which would act as a meeting point and provide a platform for dielectrics research in the UK and beyond and, as a result, a two-day Meeting was convened in the spring of 1968 at Gregynog Hall of the University of Wales, near Newtown, Montgomeryshire. It was organized by Mansel Davies, Alun Price and Graham Williams, all physical chemists from the UCW, Aberystwyth. Fifty scientists attended, being a mix of physical chemists, theoretical chemists, physicists, electrical engineers, polymer and materials scientists, all from the UK, except Dr Brendan Scaife of Trinity

  16. Structure and annual increase in a population of West Greenland caribou (Rangifer tarandus groenlandicus

    Directory of Open Access Journals (Sweden)

    Henning Thing


    elainta kussakin. Useiden satojen elainten ryhmittymia nahdaan vain kesaaikana hyttyshairioiden yhteydessa. On selva vuosittaisrytmi keskiokokoisissa tokissa siten, etta niissa tapahtuu tasaista nousua keskitalvella 1,4 elainta tokkaa kohti saavuttaen huippupisteen vasomisajan jalkeen tuskin 25 elainta tokkaa kohti. Susien puute seka alueen huonojen loppuunkuluneiden ravintovarojen takia elaimilla kaikkina vuoden aikoina on hyvin pieni laumasuuruus muiden maiden peurakantaan verrattuna. Suunnilleen 50% kannasta on vuoneloja ja vuonelovaatimia (2 v +, kun taas 2-vuotiaita ja sita vanhempia uroksia on vain 10%. Uroksien osuus kannassa osoittaa selvaa vahennysta selektiivisen metsastyksen ja luonnollisen talvikuolleisuuden aiheuttamana. Kiima on heti elainten syysvaelluksen jalkeen sisamaan kesalaitumilta rannikkojen laheisia talvialueita kohti. Talvilaidunmaiden rajoitetuista ravintomahdollisuuksista huolimatta on vasominen runsaslukuista. Tama johtuu todennakoisesti erittain hyvista laidunmaista, joita loytyy alinomaa sisamaan alueella ennen vasomisaikaa ja koko kesakauden. Kesakuun vasomisessa kanta lisaantyy uusilla yksiloilla jopa 40%, mutta kahden ensimmaisen elinkuukauden jalkeen on vasojen lukumaara vahentynyt 17 - 18 %. Suuren taantumisen syyna on erikoisesti E. colibakteerien aiheuttama kulkutautimainen niveltulehdus. Vasojen kuolleisuus syyskuusta toukokuuhun on vain noin 2 - 3 %, siten etta vuoisittainen keskimaarainen lisays on n. 15%. Kun siihen otetaan muiden ikaluokkien keskimaaraisen kuolleisuuden ylaraja, tekee kannan lisays metsastyskauden alussa elokuussa ainoastaan 10%. Ensimmaisena elinvuotena on kuolleisuus samaa suuruutta (60% kuin useimmilla peurakannoilla muilla pohjoisilla alueilla (Kuv. 7. Kuitenkin Sisimiut-kannassa vasojen vahentyminen tapahtuu melkein yksinomaa kolmen ensimmaisen kuukauden kuluessa vasomisen jalkeen, kun taas vasakuolleisuus muissa peurakannoissa on tasaisemmin jakautunut kaikkien kahdentoista kuukauden osalle.

  17. Reviewer Database

    Directory of Open Access Journals (Sweden)

    Chief Editor


    Swati BajajSwati GuhaSyed Al HussainiSyed MahmoodSyed ZaidiTabish KhanTalapalliwarTanoja BachlooTanuja PattankarTanveer BanoTanvir SidhuTarundeep SinghTauheed AhamadUday MohanUma KUmar AlishaUmesh KapilVandana JoshiVandana KakraniVartika SaxenaVarun GaikiVeena RajacharVeenu KannanVelavan AnandanVenu SettiVijaya PonnadaVijender AgrawalVineeta RawteVinod ChayalVinod SrivastavaVinoth KalidossVishruti ParchakeVishwajeet ChavanVishwanath G RVithanala DPrasadVrundaYamini MYogesh VermaZari AnjumZulfia Khan

  18. Outcomes From AAS Hack Day at the 227th AAS Meeting (United States)

    Kohler, Susanna


    will be a huge first step.Gender in Astronomy Conferences: Jim Davenport (WWU), Ben Nelson (Northwestern), Mehmet Alpsalan (NASA Ames), and Erin Maier (University of Iowa) analyzed data collected during the conference on the gender breakdown of who asks questions after oral presentations. Now in its third year, one new finding from the study is that women dont ask questions as much as men do, but they tend to ask questions more when the speaker is a woman or the first question-asker is a woman.More from #hackaas at #aas227: Gender of speaker vs. 1st to ask a question for all 3 years of Gender in Astro survey Erin Maier (@fallelujah) January 9, 2016The Early Reference Project: Many pre-1950 publications lack up-to-date citation information because the text is digitally archived as an image. Brendan Wells (UC Santa Cruz) worked with representatives from ADS and Zooniverse to set up a crowd-sourced platform to identify references in these old papers.Glassdome: Ellie Schwab (CUNY) and colleagues Paige Godfrey, Munazza Alam, and Cam Buzzard began work on a website modeled after glassdoor for safely sharing experiences throughout their astronomy careers. Glassdome will feature career path stories, department reviews, and salaries, all optionally anonymous. The site is hosted by ScienceBetter and is under development.Observing Run Sharing: Sometimes near the end of a long night at the telescope you have observed everything you need but still have time left. Short of choosing randomly or hoping a colleague is online in the middle of the night, there is currently no good solution. To address this, Brooke Simmons (UC San Diego) designed a web app that would allow astronomers to submit their favorite night sky targets. The project is still a work in progress.ArXiv Podcast: Ruth Angus (Oxford) started a podcast featuring astronomers summarizing their new papers submitted to astro-ph in one minute. Its like audio astrobites! If youve recently published a