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Sample records for kaidun ii based

  1. The Kaidun Meteorite: Where Did It Come From?

    Science.gov (United States)

    Ivanov, Andrei; Zolensky, Michael

    2003-01-01

    The Kaidun meteorite, which fell on 3.12.1980 at lat. 15 deg N, long. 48.3 deg E, holds a special place in the world meteorite collection. Kaidun is characterized by an unprecedentedly wide variety of meteorite material in its makeup. The high degree of variability in this meteorite s material is evidenced by the richness of its mineral composition - nearly 60 minerals and mineral phases have been identified in Kaidun, including several never before found in nature, such as florenskiite FeTiP, the first known phosphide of a lithophilic element.

  2. Brachinite-Like Clast in the Kaidun Meteorite: First Report of Primitive Achondrite Material

    Science.gov (United States)

    Higashi, K.; Hasegawa, H.; Mikouchi, T.; Zolensky, M. E.

    2017-01-01

    Kaidun is a brecciated meteorite containing many different types of meteorites. It is composed of carbonaceous, enstatite, ordinary and R chondrites with smaller amounts of basaltic achondrites, impact melt products and unknown [1, 2]. Because of the multiple components and high abundance of carbonaceous chondrites, the Kaidun parent body was probably a large C-type asteroid in order to have accumulated clasts of many unrelated asteroids, and thus Kaidun contains previously unknown materials[1]. It has been suggested that the Kaidun parent body trawled through different regions of the solar system [3], but the formation of Kaidun meteorite is still uncertain. In this abstract, we report the first discovery of a brachinite-like clast in Kaidun.

  3. Porphyritic Olivine-Pyroxene Clast in Kaidun: First Discovery of an Ordinary Chondrite Clast?

    Science.gov (United States)

    Mikouchi, T.; Makishima, J.; Koizumi, E.; Zolensky, M. E.

    2005-01-01

    Kaidun is an enigmatic meteorite showing a micro-brecciated texture composed of variable kinds of lithic clasts and mineral fragments. The constituent components range from primitive chondritic materials to differentiated achondritic materials, and thus believed to have originated from a large parent body accumulating materials from many different bodies in the asteroid belt. One of the interesting observations is that no ordinary chondrite component has been found yet, although C and E chondrites components are abundant. In this abstract, we report mineralogy of the clast (Kaidun #15415- 01.3.13a) showing a porphyritic olivine-pyroxene chondrule-like texture similar to those found in unequilibrated ordinary chondrites.

  4. FLUKA Monte Carlo Simulations about Cosmic Rays Interactions with Kaidun Meteorite

    Directory of Open Access Journals (Sweden)

    Turgay Korkut

    2013-01-01

    Full Text Available An asteroid called Kaidun fell on December 3, 1980, in Yemen (15° 0′N, 48° 18′E. Investigations on this large-sized meteorite are ongoing today. In this paper, interactions between cosmic rays-earth atmosphere and cosmic rays-Kaidun meteorite were modeled using a cosmic ray generator FLUKA Monte Carlo code. Isotope distributions and produced particles were given after these interactions. Also, simulation results were compared for these two types of interactions.

  5. DNA based computers II

    CERN Document Server

    Landweber, Laura F; Baum, Eric B

    1998-01-01

    The fledgling field of DNA computers began in 1994 when Leonard Adleman surprised the scientific community by using DNA molecules, protein enzymes, and chemicals to solve an instance of a hard computational problem. This volume presents results from the second annual meeting on DNA computers held at Princeton only one and one-half years after Adleman's discovery. By drawing on the analogy between DNA computing and cutting-edge fields of biology (such as directed evolution), this volume highlights some of the exciting progress in the field and builds a strong foundation for the theory of molecular computation. DNA computing is a radically different approach to computing that brings together computer science and molecular biology in a way that is wholly distinct from other disciplines. This book outlines important advances in the field and offers comprehensive discussion on potential pitfalls and the general practicality of building DNA based computers.

  6. Diet History Questionnaire II & Canadian Diet History Questionnaire II: Web-based DHQ

    Science.gov (United States)

    The Web-based versions of DHQ II and C-DHQ II are identical in content to the paper forms. By automating the DHQ II and providing versions on the Web for public use, researchers have another tool to collect and analyze food frequency questionnaire data.

  7. Copper(II), cobalt(II), nickel(II) and zinc(II) complexes of Schiff base derived from benzil-2,4-dinitrophenylhydrazone with aniline

    Indian Academy of Sciences (India)

    N Raman; S Ravichandran; C Thangaraja

    2004-06-01

    New Schiff base chelates of Cu(II), Co(II), Ni(II) and Zn(II) derived from benzil-2,4-dinitrophenylhydrazone with aniline have been synthesised. Microanalytical data, molar conductance, and magnetic susceptibility values have been obtained, and IR, 1H NMR, 13C NMR, UV-Vis, CV and EPR spectral studies have been carried out to suggest tentative structures for the complexes.

  8. Specific mercury(II) adsorption by thymine-based sorbent.

    Science.gov (United States)

    Liu, Xiangjun; Qi, Cui; Bing, Tao; Cheng, Xiaohong; Shangguan, Dihua

    2009-04-15

    A new kind of polymer sorbent based on the specific interaction of Hg(II) with nucleic acid base, thymine, is described for the selective adsorption of Hg(II) from aqueous solution. Two types of sorbents immobilized with thymine were prepared by one-step swelling and polymerization and graft polymerization, respectively. The maximum static adsorption capacity of the new polymer sorbents for Hg(II) is proportional to the density of thymine on their surface, up to 200mg/g. Moreover, the new kind polymer sorbent shows excellent selectivity for Hg(II) over other interfering ions, such as Cu(II), Cd(II), Zn(II), Co(II), Ca(II) and Mg(II), exhibits very fast kinetics for Hg(II) adsorption from aqueous solution, and can be easily regenerated by 1.0M HCl. It also has been successfully used for the selective adsorption of spiked Hg(II) from real tap water samples. This new thymine polymer sorbent holds a great promise in laboratory and industrial applications such as separation, on-line enrichment, solid-phase extraction, and removal of Hg(II) from pharmaceutical, food and environmental samples.

  9. Synthesis, spectroscopic, antimicrobial and DNA cleavage studies of new Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes with naphthofuran-2-carbohydrazide Schiff base

    Science.gov (United States)

    Halli, Madappa B.; Sumathi, R. B.

    2012-08-01

    A series of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes have been synthesized with newly synthesized Schiff base derived from naphthofuran-2-carbohydrazide and cinnamaldehyde. The elemental analyses of the complexes are confined to the stoichiometry of the type MLCl2 [M = Co(II) and Cu(II)], ML2Cl2 [M = Ni(II), Cd(II), Zn(II) and Hg(II)] respectively, where L is Schiff base ligand. Structures have been proposed from elemental analyses, IR, electronic, mass, 1H NMR, ESR spectral data, magnetic, and thermal studies. The measured low molar conductance values in DMF indicate that the complexes are non-electrolytes. Spectroscopic studies suggest coordination occurs through azomethine nitrogen and carbonyl oxygen of the ligand with the metal ions. The Schiff base and its complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal (Aspergillus niger, Aspergillus flavus, Cladosporium and Candida albicans) activities by minimum inhibitory concentration (MIC) method. The DNA cleavage studies by agarose gel electrophoresis method was studied for all the complexes.

  10. Structural and Spectroscopic Aspects of Schiff Base Metal Complexes of Cobalt(II, Nickel(II and Copper(II

    Directory of Open Access Journals (Sweden)

    B.K. Rai

    2014-09-01

    Full Text Available The complexes of Co(II, Ni(II and Cu(II with Schiff base 2-butyl thioquinazoline 4(3H thiosemicarbazone were synthesized. The general formulae of the complexes are of the type {M(L2X2], L=2 – butyl thioquinazoline 4(3H thiosemicarbazone; x = Cl-, Br-, I- and NO3-. Elemental analyses and spectral (IR, electronic studies of the synthesized complexes suggest the presence of octahedral, environment around the central metal ion. These complexes were also subjected to study their antimicrobial screening against, Gram positive bacteria Candida albicans and gram negative bacteria Escherichia coli by disc diffusion technique.

  11. Investigation of the oxygen affinity of manganese(II, cobalt(II and nickel(II complexes with some tetradentate Schiff bases

    Directory of Open Access Journals (Sweden)

    Adel A.A. Emara

    2014-12-01

    Full Text Available Oxygen absorption–desorption processes for square planar Mn(II, Co(II and Mn(II complexes of tetradentate Schiff base ligands in DMF and chloroform solvents were investigated. The tetradentate Schiff base ligands were obtained by condensation reaction of ethylenediamine with salcyldehyde, o-hydroxyacetophenone or acetylacetone in the molar ratio 1:2. The square planar complexes were prepared by the reaction of the Schiff base ligands with Mn(II acetate, Co(II nitrate and Ni(II nitrate in dry ethanol under nitrogen atmosphere. The sorption processes were undertaken in the presence and absence of (pyridine axial-base in 1:1 M ratio of (pyridine:metal(II complexes. Complexes in DMF indicate significant oxygen affinity than in chloroform solvent. Cobalt(II complexes showed significant sorption processes compared to Mn(II and Ni(II complexes. The presence of pyridine axial base clearly increases oxygen affinity.

  12. Utility-based optimization of phase II/III programs.

    Science.gov (United States)

    Kirchner, Marietta; Kieser, Meinhard; Götte, Heiko; Schüler, Armin

    2016-01-30

    Phase II and phase III trials play a crucial role in drug development programs. They are costly and time consuming and, because of high failure rates in late development stages, at the same time risky investments. Commonly, sample size calculation of phase III is based on the treatment effect observed in phase II. Therefore, planning of phases II and III can be linked. The performance of the phase II/III program crucially depends on the allocation of the resources to phases II and III by appropriate choice of the sample size and the rule applied to decide whether to stop the program after phase II or to proceed. We present methods for a program-wise phase II/III planning that aim at determining optimal phase II sample sizes and go/no-go decisions in a time-to-event setting. Optimization is based on a utility function that takes into account (fixed and variable) costs of the drug development program and potential gains after successful launch. The proposed methods are illustrated by application to a variety of scenarios typically met in oncology drug development.

  13. Greedy Snake Video Game Based on Nios II System

    OpenAIRE

    2014-01-01

    With the development of large scale integrated circuit, traditional embedded system design method cannot meet the requirements for building complex systems. Therefore, SOC and SOPC technology are widely used nowadays. This thesis aims to development a game platform based on Nios II system using Altera DE2 development and education board and SOPC technology. In this thesis, first a custom Nios II system was built according to the requirements of the game application. The system contains hardwa...

  14. Synthesis, Spectral Characterization, Molecular Modeling, and Antimicrobial Studies of Cu(II, Ni(II, Co(II, Mn(II, and Zn(II Complexes of ONO Schiff Base

    Directory of Open Access Journals (Sweden)

    Padmaja Mendu

    2012-01-01

    Full Text Available A series of Cu(II, Ni(II, Co(II, Mn(II, and Zn(II complexes have been synthesized from the schiff base ligand L. The schiff base ligand [(4-oxo-4H-chromen-3-yl methylene] benzohydrazide (L has been synthesized by the reaction between chromone-3-carbaldehyde and benzoyl hydrazine. The nature of bonding and geometry of the transition metal complexes as well as schiff base ligand L have been deduced from elemental analysis, FT-IR, UV-Vis, 1HNMR, ESR spectral studies, mass, thermal (TGA and DTA analysis, magnetic susceptibility, and molar conductance measurements. Cu(II, Ni(II, Co(II, and Mn(II metal ions are forming 1:2 (M:L complexes, Zn(II is forming 1:1 (M:L complex. Based on elemental, conductance and spectral studies, six-coordinated geometry was assigned for Cu(II, Ni(II, Co(II, Mn(II, and Zn(II complexes. The complexes are 1:2 electrolytes in DMSO except zinc complex, which is neutral in DMSO. The ligand L acts as tridentate and coordinates through nitrogen atom of azomethine group, oxygen atom of keto group of γ-pyrone ring and oxygen atom of hydrazoic group of benzoyl hydrazine. The 3D molecular modeling and energies of all the compounds are furnished. The biological activity of the ligand and its complexes have been studied on the four bacteria E. coli, Edwardella, Pseudomonas, and B. subtilis and two fungi pencillium and tricoderma by well disc and fusion method and found that the metal chelates are more active than the free schiff base ligand.

  15. Synthesis and characterization of VO(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based azo-linked Schiff base ligand

    Science.gov (United States)

    Anitha, C.; Sheela, C. D.; Tharmaraj, P.; Johnson Raja, S.

    2012-12-01

    Azo-Schiff-base complexes of VO(II), Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized and characterized by elemental analysis, IR, UV-Vis, 1H NMR, mass spectra, molar conductance, magnetic susceptibility measurement, electron spin resonance (EPR), CV, fluorescence, NLO and SEM. The conductance data indicate the nonelectrolytic nature of the complexes, except VO(II) complex which is electrolytic in nature. On the basis of electronic spectra and magnetic susceptibility octahedral geometry has been proposed for the complexes. The EPR spectra of copper and oxovanadium complexes in DMSO at 300 and 77 K were recorded and its salient features are reported. The redox behavior of the copper(II) complex was studied using cyclic voltammetry. The in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella enterica typhi, Bacillus subtilis and Candida strains was studied and compared with that of free ligand by well-diffusion technique. The azo Schiff base exhibited fluorescence properties originating from intraligand (π-π∗) transitions and metal-mediated enhancement is observed on complexation and so the synthesized complexes can serve as potential photoactive materials as indicated from their characteristic fluorescence properties. On the basis of the optimized structures, the second-order nonlinear optical properties (NLO) are calculated by using second-harmonic generation (SHG) and also the surface morphology of the complexes was studied by SEM.

  16. Enhanced Materials Based on Submonolayer Type-II Quantum Dots

    Energy Technology Data Exchange (ETDEWEB)

    Tamargo, Maria C [City College of New York, NY (United States); Kuskovsky, Igor L. [City Univ. (CUNY), NY (United States) Queens College; Meriles, Carlos [City College of New York, NY (United States); Noyan, Ismail C. [Columbia Univ., New York, NY (United States)

    2017-04-15

    We have investigated a nanostructured material known as sub-monolayer type-II QDs, made from wide bandgap II-VI semiconductors. Our goal is to understand and exploit their tunable optical and electrical properties by taking advantage of the type-II band alignment and quantum confinement effects. Type-II ZnTe quantum dots (QDs) in a ZnSe host are particularly interesting because of their relatively large valence band and conduction band offsets. In the current award we have developed new materials based on sub-monolayer type-II QDs that may be advantageous for photovoltaic and spintronics applications. We have also expanded the structural characterization of these materials by refining the X-ray diffraction methodologies needed to investigate them. In particular, we have 1) demonstrated ZnCdTe/ZnCdSe type-II QDs materials that have ideal properties for the development of novel high efficiency “intermediate band solar cells”, 2) we developed a comprehensive approach to describe and model the growth of these ultra-small type-II QDs, 3) analysis of the evolution of the photoluminescence (PL) emission, combined with other characterization probes allowed us to predict the size and density of the QDs as a function of the growth conditions, 4) we developed and implemented novel sophisticated X-ray diffraction techniques from which accurate size and shape of the buried type-II QDs could be extracted, 5) a correlation of the shape anisotropy with polarization dependent PL was observed, confirming the QDs detailed shape and providing insight about the effects of this shape anisotropy on the physical properties of the type-II QD systems, and 6) a detailed “time-resolved Kerr rotation” investigation has led to the demonstration of enhanced electron spin lifetimes for the samples with large densities of type-II QDs and an understanding of the interplay between the QDs and Te-isoelectroic centers, a defect that forms in the spacer layers that separate the QDs.

  17. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide

    Indian Academy of Sciences (India)

    N Raman; Y Pitchaikani Raja; A Kulandaisamy

    2001-06-01

    Neutral tetradentate N2O2 type complexes of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) have been synthesised using a Schiff base formed by the condensation of -phenylenediamine with acetoacetanilide in alcohol medium. All the complexes were characterised on the basis of their microanalytical data, molar conductance, magnetic susceptibility, IR, UV-Vis 1H NMR and ESR spectra. IR and UV-Vis spectral data suggest that all the complexes are square-planar except the Mn(II) and VO(II) chelates, which are of octahedral and square pyramidal geometry respectively. The monomeric and neutral nature of the complexes was confirmed by their magnetic susceptibility data and low conductance values. The ESR spectra of copper and vanadyl complexes in DMSO solution at 300 K and 77 K were recorded and their salient features are reported.

  18. Silicon nanowires-based fluorescence sensor for Cu(II).

    Science.gov (United States)

    Mu, Lixuan; Shi, Wensheng; Chang, Jack C; Lee, Shuit-Tong

    2008-01-01

    Si nanowires (SiNWs) were covalently modified by fluorescence ligand, N-(quinoline-8-yl)-2-(3-triethoxysilyl-propylamino)-acetamide (QlOEt) and finally formed an optical sensor to realize a highly sensitive and selective detection for Cu(II). The QlOEt-modified SiNWs sensor has sensitivity for Cu(II) down to 10(-8) M, which is more sensitive than QlOEt alone. Metal ions interferences have no observable effect on the sensitivity and selectivity of QlOEt-modified SiNWs sensor. The SiNWs-based fluorescence sensor is reversible by addition of acid to replace Cu(II). The sensing mechanisms of QlOEt-modified SiNWs to Cu(II) and the rationale for the increase in sensitivity and selectivity of QlOEt-modified SiNWs over QlOEt on Cu(II) are discussed. The current sensor structure may be extendable to other chemo- and biosensors, and even to nanosensors for direct detection of specific materials in intracellular environment.

  19. Synthesis, characterization and biological activity of some new VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based NNO Schiff base derived from 2-aminothiazole

    Science.gov (United States)

    Kalanithi, M.; Kodimunthiri, D.; Rajarajan, M.; Tharmaraj, P.

    2011-11-01

    Coordination compounds of VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) with the Schiff base obtained through the condensation of 2-aminothiazole with 3-formyl chromone were synthesized. The compounds were characterized by 1H, 13C NMR, UV-Vis, IR, Mass, EPR, molar conductance and magnetic susceptibility measurements. The Cu(II) complex possesses tetrahedrally distorted square planar geometry whereas Co(II), Ni(II), and Zn(II) show distorted tetrahedral geometry. The VO(IV) complex shows square pyramidal geometry. The cyclic voltammogram of Cu (II) complex showed a well defined redox couple Cu(II)/Cu(I) with quasireversible nature. The antimicrobial activity against the species Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albigans and Aspergillus niger was screened and compared to the activity of the ligand. Emission spectrum was recorded for the ligand and the metal(II) complexes. The second harmonic generation (SHG) efficiency was measured and found to have one fourth of the activity of urea. The SEM image of the copper(II) complex implies that the size of the particles is 2 μm.

  20. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON Co (II, Ni (II, Cu (II AND Zn (II COMPLEXES OF N, O, DONAR HETEROCYCLIC SCHIFF BASES Synthese, Charakterisierung und antimikrobiellen STUDIES ON Co (II, Ni (II, Cu (II und Zn (II-Komplexe von N, O, DONAR HETEROCYCLISCHE SCHIFF BASES

    Directory of Open Access Journals (Sweden)

    R.Shakru, N.J.P.Subhashini, Acharyanagarjuna,Shivaraj

    2011-08-01

    Full Text Available The Schiff base ligands L1 4-allyl-2-{[(5'-methyl-3'-isoxazolylimino]methyl}phenol [AMIIMP] and L2 N-[5'-methyl-3'-isoxazolyl]-[(EPyridine]methylidine]amine[MIPMA] have been synthesized by the condensation of 4-allyl 2- hydroxyl 1-benzaldehyde and Pyridine 3- carboxaldehyde with 3- amino 5-methy isoxazole. The metal chelates of L1 and L2 with Cobalt (II, Nickel (II, Copper (II and Zn (II metal ions have been synthesised and characterized on the basis of elemental analysis, IR, 1H- NMR, Mass, Electronic spectra and magnetic moment studies. From these studies it is found that ligands act as bivalent chelating agents coordinating through oxygen and nitrogen donor atoms in the case of AMIIMP, and pyridine nitrogen and imino nitrogen donar atoms of in the case of MIPMA. The chelates of Co (II, Ni (II and Zn (II appear to be octahedral geometry and Cu (II appears to be tetragonal geometry. Antimicrobial activity of the ligands and their metal complexes against bacteria (Bacillus, Pseudomonas and fungus (R. Solani, A. Niger has been carried out. It is found that the metal complexes have higher activities than those of free ligands.

  1. Synthesis, characterization, DFT calculations and biological studies of Mn(II), Fe(II), Co(II) and Cd(II) complexes based on a tetradentate ONNO donor Schiff base ligand

    Science.gov (United States)

    Abdel-Rahman, Laila H.; Ismail, Nabawia M.; Ismael, Mohamed; Abu-Dief, Ahmed M.; Ahmed, Ebtehal Abdel-Hameed

    2017-04-01

    This study highlights synthesis and characterization of a tetradentate ONNO Schiff base ligand namely (1, 1‧- (pyridine-2, 3-dimethyliminomethyl) naphthalene-2, 2‧-diol) and hereafter denotes as "HNDAP″ and selected metal complexes including Mn(II), Fe(II), Co(II) and Cd(II) as a central metal. HNDAP was synthesized from 1:2 M ratio condensation of 2, 3-diaminopyridine and 2- hydroxy-1-naphthaldhyde, respectively. The stoichiometric ratios of the prepared complexes were estimated using complementary techniques such as; elemental analyses (-C, H, N), FT-IR, magnetic measurements and molar conductivity. Furthermore, their physicochemical studies were carried out using thermal TGA, DTA and kinetic-thermodynamic studies along with DFT calculations. The results of elemental analyses showed that these complexes are present in a 1:1 metal-to- ligand molar ratio. Moreover, the magnetic susceptibilities values at room temperature revealed that Mn(II), Fe(II) and Co(II) complexes are paramagnetic in nature and have an octahedral (Oh) geometry. In contrast, Cd(II) is diamagnetic and stabilizes in square planar sites. The molar conductivity measurements indicated that all complexes are nonelectrolytes in dimethyl formamide. Spectral data suggested that the ligand is as tetradentate and coordinated with Co(II) ion through two phenolic OH and two azomethine nitrogen. However, for Mn(II), Fe(II) and Cd(II) complexes, the coordination occurred through two phenolic oxygen and two azomethine nitrogen with deprotonation of OH groups. The proposed chemical structures have been validated by quantum mechanics calculations. Antimicrobial activities of both the HNDAP Schiff base ligand and its metal complexes were tested against strains of Gram (-ve) E. coli and Gram (+ve) B. subtilis and S. aureus bacteria and C. albicans, A. flavus and T. rubrum fungi. All the prepared compounds showed good results of inhibition against the selected pathogenic microorganisms. The investigated

  2. Coordination Modes of a Schiff Base Derived from Substituted 2-Aminothiazole with Chromium(III, Manganese(II, Iron(II, Cobalt(II, Nickel(II and Copper(II Metal Ions: Synthesis, Spectroscopic and Antimicrobial Studies

    Directory of Open Access Journals (Sweden)

    Ambit Thakar

    2011-01-01

    Full Text Available Transition metal complexes of Cr(III, Mn(II, Fe(II, Co(II, Ni(II and Cu(II metal ions with general stoichiometry [ML2.2H2O] and [ML3], where M= Mn(II, Cr(III, Fe(II, Co(II, Ni(II and Cu(II, L= Schiff base derived from the condensation of 2-amino-4(4’-phenyl/methylphenyl-5-methyl-thiazole with 4-acetyl-1(3-chloro phenyl-3-methyl-2-pyrazoline-5-ones, have been synthesized and structurally characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements and spectral techniques like IR, UV, 1H NMR, 13C NMR and Mass Spectra. All the complexes were found to be octahedral geometry. The ligand and its complexes have been screened for their antifungal and antibacterial activities against three fungi, i.e. Alternaria brassicae, Aspergillus niger and Fesarium oxysporum and two bacteria, i.e. Xanthomonas compestris and Pseudomonas aeruginosa.

  3. Ethernet-Based DAQ System for QUIET-II Detectors

    Science.gov (United States)

    Nagai, M.; Ishidoshiro, K.; Higuchi, T.; Ikeno, M.; Hasegawa, M.; Hazumi, M.; Tajima, O.; Tanaka, M.; Uchida, T.

    2012-06-01

    The B-modes in cosmic microwave background polarization are a smoking gun for the inflationary universe. For the detection of the B-modes, having a large detector array is a generic approach since the B-modes is so faint pattern ( T b≲0.1 μK). The Q/U Imaging ExperimenT Phase-II (QUIET-II) is proposed to search the B-modes, using an array with 500 HEMT-based polarimeters. Each polarimeter element has 4-outputs, therefore we have to manage 2000 channels in total. We developed a scalable DAQ system based on TCP/Ethernet for QUIET-II. The DAQ system is composed of the polarimeters, ADC boards, a Master Clock and a control computer (PC). The analog signals from the polarimeters are digitized on the ADC boards. On-board demodulation, which synchronizes the phase flip modulations on the polarimeter, extracts the polarized components in the digitized signal. The Master Clock distributes all necessary clocks to the ADC boards as well as the polarimeters. This scheme guarantees the synchronization of the modulations and demodulations. We employed Ethernet-based communication scheme between the data collection program (Collector) on the PC and the ADC boards as well as the Master Clock. Such an Ethernet-based communication scheme allows us to construct a simple structure of the upper level software, which results in the high scalability to increase the number of channels. All basic functions and requirements are confirmed by the laboratory tests; demonstration with test signals as well as the signals from the polarimeters, measurements of the data transfer rate, and the synchronous operation with two ADC boards. Therefore, the DAQ system is confirmed to be suitable for QUIET-II.

  4. FPGA based algorithms for data reduction at Belle II

    Energy Technology Data Exchange (ETDEWEB)

    Muenchow, David; Gessler, Thomas; Kuehn, Wolfgang; Lange, Jens Soeren; Liu, Ming; Spruck, Bjoern [II. Physikalisches Institut, Universitaet Giessen (Germany)

    2011-07-01

    Belle II, the upgrade of the existing Belle experiment at Super-KEKB in Tsukuba, Japan, is an asymmetric e{sup +}e{sup -} collider with a design luminosity of 8.10{sup 35}cm{sup -2}s{sup -1}. At Belle II the estimated event rate is {<=}30 kHz. The resulting data rate at the Pixel Detector (PXD) will be {<=}7.2 GB/s. This data rate needs to be reduced to be able to process and store the data. A region of interest (ROI) selection is based upon two mechanisms. a.) a tracklet finder using the silicon strip detector and b.) the HLT using all other Belle II subdetectors. These ROIs and the pixel data are forwarded to an FPGA based Compute Node for processing. Here a VHDL based algorithm on FPGA with the benefit of pipelining and parallelisation will be implemented. For a fast data handling we developed a dedicated memory management system for buffering and storing the data. The status of the implementation and performance tests of the memory manager and data reduction algorithm is presented.

  5. Dinuclear cadmium(II), zinc(II), and manganese(II), trinuclear nickel(II), and pentanuclear copper(II) complexes with novel macrocyclic and acyclic Schiff-base ligands having enantiopure or racemic camphoric diamine components.

    Science.gov (United States)

    Jiang, Jue-Chao; Chu, Zhao-Lian; Huang, Wei; Wang, Gang; You, Xiao-Zeng

    2010-07-05

    Four novel [3 + 3] Schiff-base macrocyclic ligands I-IV condensed from 2,6-diformyl-4-substituted phenols (R = CH(3) or Cl) and enantiopure or racemic camphoric diamines have been synthesized and characterized. Metal-ion complexations of these enantiopure and racemic [3 + 3] macrocyclic ligands with different cadmium(II), zinc(II), manganese(II), nickel(II), and copper(II) salts lead to the cleavage of Schiff-base C horizontal lineN double bonds and subsequent ring contraction of the macrocyclic ligands due to the size effects and the spatial restrictions of the coordination geometry of the central metals, the steric hindrance of ligands, and the counterions used. As a result, five [2 + 2] and one [1 + 2] dinuclear cadmium(II) complexes (1-6), two [2 + 2] dinuclear zinc(II) (7 and 8), and two [2 + 2] dinuclear manganese(II) (9 and 10) complexes together with one [1 + 1] trinuclear nickel(II) complex (11) and one [1 + 2] pentanuclear copper(II) complex (12), bearing enantiopure or racemic ligands, different substituent groups in the phenyl rings, and different anionic ligands (Cl(-), Br(-), OAc(-), and SCN(-)), have been obtained in which the chiral carbon atoms in the camphoric backbones are arranged in different ways (RRSS for the enantiopure ligands in 1, 2, 4, 5, and 7-10 and RSRS for the racemic ligands in 3, 6, 11, and 12). The steric hindrance effects of the methyl group bonded to one of the chiral carbon atoms of camphoric diamine units are believed to play important roles in the formation of the acyclic [1 + 1] trinuclear complex 11 and [1 + 2] dinuclear and pentanuclear complexes 6 and 12. In dinuclear cadmium(II), zinc(II), and manganese(II) complexes 1-10, the sequence of separations between the metal centers is consistent with that of the ionic radii shortened from cadmium(II) to manganese(II) to zinc(II) ions. Furthermore, UV-vis, circular dichroism, (1)H NMR, and fluorescence spectra have been used to characterize and compare the structural

  6. Spectroscopic, DNA binding ability, biological activity, DFT calculations and non linear optical properties (NLO) of novel Co(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes with ONS Schiff base

    Science.gov (United States)

    Abdel Aziz, Ayman A.; Elantabli, Fatma M.; Moustafa, H.; El-Medani, Samir M.

    2017-08-01

    The reaction of Co(II), Cu(II), Zn(II), Cd(II) and Hg(II) with the synthesized N-(2-hydroxy-1-naphthylidene)-2-aminothiophenol Schiff base ligand (H2L) at room temperature resulted in the formation of the five complexes; [Co(HL)2]H2O, 1; [M(HL)2] (M = Cu, Zn and Cd), (2-4) and [Hg(HL)Cl], 5. The ligand and its complexes were characterized based on elemental analyses, IR, 1H NMR, magnetic measurement, molar conductance, and thermal analysis. Coats and Redfern method was used to compute the kinetic and thermodynamic parameters. Antimicrobial activities of H2L and its complexes have been studied. The binding of Co(II), Cu(II) and Zn(II) complexes to calf thymus DNA (CT-DNA) has been investigated using UV-Vis and fluorescence absorption spectra. The results indicated that the ligand and its complexes may bind to DNA by intercalation modes, with a much higher binding affinity of the complexes than that of the ligand. The equilibrium geometries of the studied complexes are investigated theoretically at the B3LYP/LANL2DZ level of theory, and it was found that these geometries are non-linear. The calculated EHOMO and ELUMO energies of the studied complexes can be used to calculate the global properties. The calculated nonlinear optical parameters (NLO); first order hyperpolarizibility (β) of the studied complexes show promising optical properties.

  7. Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-α-aminobutyric acid

    Science.gov (United States)

    Nair, M. Sivasankaran; Joseyphus, R. Selwin

    2008-09-01

    Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from vanillin and DL-α-aminobutyric acid were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, magnetic measurements, powder XRD and biological activity. The analytical data show the composition of the metal complex to be [ML(H 2O)], where L is the Schiff base ligand. The conductance data indicate that all the complexes are non-electrolytes. IR results demonstrate the tridentate binding of the Schiff base ligand involving azomethine nitrogen, phenolic oxygen and carboxylato oxygen atoms. The IR data also indicate the coordination of a water molecule with the metal ion in the complex. The electronic spectral measurements show that Co(II) and Ni(II) complexes have tetrahedral geometry, while Cu(II) complex has square planar geometry. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, whereas Ni(II) and Zn(II) complexes are crystalline in nature. Magnetic measurements show that Co(II), Ni(II) and Cu(II) complexes have paramagnetic behaviour. Antibacterial results indicated that the metal complexes are more active than the ligand.

  8. Commercial Applications at FRM II Based on Neutron Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Gerstenberg, H.; Draack, A.; Kastenmuller, A. [Technische Universitaet Muenchen, Munchen (Germany)

    2013-07-01

    Due to its design as a heavy water moderated reactor with a very compact core FRM II, Germany's most modern and most powerful research reactor, offers excellent conditions for basic research using beam tubes. On the other hand it is equipped with various irradiation facilities to be used mainly for industrial purposes. From the very beginning of reactor operation a dedicated department had been implemented in order to provide a neutron irradiation service to interested parties on a commercial basis. As of today the most widely used application is Si doping. The semiautomatic doping facility accepts ingots with diameters between 125 mm and 200 mm and a maximum height of 500 mm. The irradiation channel is located deep in the heavy water tank and exhibits a ratio of thermal/fast neutron flux density of > 1000. This value allows the doping of Si to a target resistivity as high as 1100 Ωcm within the tight limits regarding accuracy and homogeneity specified by the customer. Typically the throughput of Si doped in FRM II sums up to about 15 t/year. Another topic of growing importance is the use of FRM II aiming the production of radioisotopes mainly for the radiopharmaceutical industry. The maybe most challenging example is the production of Lu-177 n. c. a. based on the irradiation of Yb{sub 2}O{sub 3} to a high fluence of thermal neutrons of typically 1.5E20 cm{sup -2}. The Lu-177 activity delivered to the customer is in the range of 750 GBq. With respect to further processing it turned out to be a highly advantageous to have the laboratories of ITG, the company extracting the Lu-177 from the freshly irradiated Yb{sub 2}O{sub 3} on site FRM II. Further irradiation facilities are available at FRM II in order to allow the activation of samples for analytical purposes or to irradiate samples for geochronological investigations using the fission track technique. Finally a project on the future installation of a facility dedicated to the irradiation of U-targets for

  9. Removal of Ni(II), Zn(II) and Pb(II) ions from single metal aqueous solution using rice husk-based activated carbon

    Energy Technology Data Exchange (ETDEWEB)

    Taha, Mohd F., E-mail: faisalt@petronas.com.my; Shaharun, Maizatul S. [Fundamental and Applied Sciences Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 31750, Perak Darul Ridzuan (Malaysia); Shuib, Anis Suhaila, E-mail: anisuha@petronas.com.my; Borhan, Azry [Chemical Engineering Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 31750, Perak Darul Ridzuan (Malaysia)

    2014-10-24

    An attempt was made to investigate the potential of rice husk-based activated carbon as an alternative low-cost adsorbent for the removal of Ni(II), Zn(II) and Pb(II) ions from single aqueous solution. Rice husk-based activated carbon was prepared via treatment of rice husk with NaOH followed by the carbonization process at 400°C for 2 hours. Three samples, i.e. raw rice husk, rice husk treated with NaOH and rice husk-based activated carbon, were analyzed for their morphological characteristics using field-emission scanning electron microscope/energy dispersive X-ray (FESEM/EDX). These samples were also analyzed for their carbon, hydrogen, nitrogen, oxygen and silica contents using CHN elemental analyzer and FESEM/EDX. The porous properties of rice husk-based activated carbon were determined by Brunauer-Emmett-Teller (BET) surface area analyzer, and its surface area and pore volume were 255 m{sup 2}/g and 0.17 cm{sup 2}/g, respectively. The adsorption studies for the removal of Ni(II), Zn(II) and Pb(II) ions from single metal aqueous solution were carried out at a fixed initial concentration of metal ion (150 ppm) with variation amount of adsorbent (rice husk-based activated carbon) as a function of varied contact time at room temperature. The concentration of each metal ion was analyzed using atomic absorption spectrophotometer (AAS). The results obtained from adsorption studies indicate the potential of rice husk as an economically promising precursor for the preparation of activated carbon for removal of Ni(II), Zn(II) and Pb(II) ions from single aqueous solution. Isotherm and kinetic model analyses suggested that the experimental data of adsorption studies fitted well with Langmuir, Freundlich and second-order kinetic models.

  10. Technology transfer package on seismic base isolation - Volume II

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-02-14

    This Technology Transfer Package provides some detailed information for the U.S. Department of Energy (DOE) and its contractors about seismic base isolation. Intended users of this three-volume package are DOE Design and Safety Engineers as well as DOE Facility Managers who are responsible for reducing the effects of natural phenomena hazards (NPH), specifically earthquakes, on their facilities. The package was developed as part of DOE's efforts to study and implement techniques for protecting lives and property from the effects of natural phenomena and to support the International Decade for Natural Disaster Reduction. Volume II contains the proceedings for the Short Course on Seismic Base Isolation held in Berkeley, California, August 10-14, 1992.

  11. Co (II and Zn (II Metal Complexes of Heterocyclic Schiff Bases: A Synthesis, Spectral and Antimicrobial Study

    Directory of Open Access Journals (Sweden)

    Sachin R. Joshi

    2014-09-01

    Full Text Available The Schiff bases have been synthesised by the reaction of Benzoinoxime primary ligand with heterocyclic compounds such as 2-aminothiazole (SL1 and 8-hydroxyquinoline (SL2 to form the secondary ligand, which than react with the metal halides to form complexes of Co (II and Zn (II. The elemental analysis data shows that the metal to ligand ratio in all Co (II simple is 1:2 for simple complexes and 1:2:2 for metal complex with oxime as a primary ligand and SL1 as a secondary ligand while it is 1:2:1 for metal complex with oxime as a primary ligand and SL3 as a secondary ligand whereas Zn (II complexes of mixed ligand exhibit the stoichiometry 1:2:2. The structural features have been determined from IR, UV-Vis, and XRD data. All the complex shows a distorted octahedral geometry to mononuclear Co (II complexes of mixed ligands, while square planner geometry to mononuclear Co (II complexes of oximes. Zn (II complexes of mixed ligands shows a distorted octahedral geometry, while square planner geometry to mononuclear Zn (II complexes of oximes. All the synthesised compounds were screened for antimicrobial activity.

  12. Synthesis, characterization, and antioxidant/cytotoxic activity of new chromone Schiff base nano-complexes of Zn(II), Cu(II), Ni(II) and Co(II)

    Science.gov (United States)

    Saif, M.; El-Shafiy, Hoda F.; Mashaly, Mahmoud M.; Eid, Mohamed F.; Nabeel, A. I.; Fouad, R.

    2016-08-01

    A chromone Schiff base complexes of Zn(II) (1), Cu(II) (2), Ni(II) (3) and Co(II) (4) were successfully prepared in nano domain with crystalline or amorphous structures. The spectroscopic data revealed that the Schiff base ligand behaves as a monoanionic tridentate ligand. The metal complexes exhibited octahedral geometry. Transmission electron microscope (TEM) analysis showed that Cu(II) complex have aggregated nanospheres morphology. The obtained nano-complexes were tested as antioxidant and antitumor agents. The H2L and its Cu(II) complex (2) were found to be more potent antioxidant (IC50(H2L) = 0.93 μM; IC50(Cu(II) complex) = 1.1 μM than standard ascorbic acid (IC50 = 2.1 μM) as evaluated by DPPH• method. The H2L and its complexes (1-4) were tested for their in vitro cytotoxicity against Ehrlich Ascites Carcinoma cell line (EAC). The Cu(II) nano-complex (2) effectively inhibited EAC growth with IC50 value of 47 μM in comparison with its parent compound and other prepared complexes. The high antioxidant activity and antitumor activity of Cu(II) nano-complex (2) were attributed to their chemical structure, Cu(II) reducing capacity, and nanosize property. The toxicity test on mice showed that Zn(II) (1) and Cu(II) (2) nano-complex have lower toxicity than the standard cis-platin.

  13. High Quantum Efficiency Type II SLS FPAs for Space-Based Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase II SBIR proposes to develop high quantum efficiency (QE) and low dark current infrared epitaxy materials based on Type II Strained Layer Superlattice...

  14. Large area radiation detectors based on II VI thin films

    Science.gov (United States)

    Quevedo-Lopez, Manuel

    2015-03-01

    The development of low temperature device technologies that have enabled flexible displays also present opportunities for flexible electronics and flexible integrated systems. Of particular interest are possible applications in flexible, low metal content, sensor systems for unattended ground sensors, smart medical bandages, electronic ID tags for geo-location, conformal antennas, neutron/gamma-ray/x-ray detectors, etc. In this talk, our efforts to develop novel CMOS integration schemes, circuits, memory, sensors as well as novel contacts, dielectrics and semiconductors for flexible electronics are presented. In particular, in this presentation we discuss fundamental materials properties including crystalline structure, interfacial reactions, doping, etc. defining performance and reliability of II-VI-based radiation sensors. We investigate the optimal thickness of a semiconductor diode for thin-film solid state thermal neutron detectors. Besides II-VI materials, we also evaluated several diode materials, Si, CdTe,GaAs, C (diamond), and ZnO, and two neutron converter materials,10B and 6LiF. We determine the minimum semiconductor thickness needed to achieve maximum neutron detection efficiency. By keeping the semiconductor thickness to a minimum, gamma rejection is kept as high as possible. In this way, we optimize detector performance for different thin-film semiconductor materials.

  15. Co(II), Ni(II) and Cu(II) complexes with coumarin-8-yl Schiff-bases: spectroscopic, in vitro antimicrobial, DNA cleavage and fluorescence studies.

    Science.gov (United States)

    Patil, Sangamesh A; Unki, Shrishila N; Kulkarni, Ajaykumar D; Naik, Vinod H; Badami, Prema S

    2011-09-01

    A new series of Co(II), Ni(II) and Cu(II) complexes of the type ML·2H2O of Schiff-bases derived from m-substituted thiosemicarbazides and 8-acetyl-7-hydroxy-4-methylcoumarin have been synthesized and characterized by spectroscopic studies. Schiff-bases exhibit thiol-thione tautomerism wherein sulphur plays an important role in the coordination. The coordination possibility of the Schiff-bases towards metal ions have been proposed in the light of elemental analyses, spectral (IR, UV-vis, FAB-mass, ESR and fluorescence), magnetic and thermal studies. The low molar conductance values in DMF indicate that, the metal complexes are non-electrolytes. The cyclic voltammetric studies suggested that, the Cu(II) and Ni(II) complexes are of single electron transfer quasi-reversible nature. The Schiff-bases and its metal complexes have been evaluated for their in vitro antibacterial (Escherichia coli, Staphilococcus aureus, Bascillus subtilis and Salmonella typhi) and antifungal activities (Candida albicans, Cladosporium and Aspergillus niger) by MIC method. The Schiff-base I and its metal complexes exhibited DNA cleavage activity on isolated DNA of A. niger.

  16. Predicting outcomes in organophosphate poisoning based on APACHE II and modified APACHE II scores.

    Science.gov (United States)

    Eizadi-Mood, N; Saghaei, M; Jabalameli, M

    2007-07-01

    The aim of this study was to evaluate the scores of the Acute Physiology and Chronic Health Evaluation (APACHE) II and a modified APACHE II system (MAS), without parameters of biochemical tests; and to find prognostic value of individual elements of the APACHE II and MAS in predicting outcomes in organophosphate (OP) poisoning. Data were collected from 131 patients. The median (25th-75th percentiles) of APACHE II score for survivors without intubation were found to be lower than those of non survivors or survivors with intubation and ventilation, [4 (1-7); versus 17.5 (7.8-29), and 13.5 (7.8-16.3)]. Logistic regression analysis identified white blood cell (WBC), potassium, Glasgow coma scale (GCS), age and sodium in APACHE II; GCS and mean arterial pressure in MAS system as prognostically valuable. There was no statistically significance difference between APACHE II and MAS scores in terms of area under Receiver Operating Characteristic Curve [(0.902, 95% confidence interval: (0.837-0.947) for APACHE II), and (0.892, 95% confidence interval: (0.826-0.940) for MAS); P=0.74) to predict need for intubation. It is concluded usage of MAS facilitates the prognostication of the OP poisoned patients due to simplicity, less time-consuming and effectiveness in an emergency situation.

  17. Unusual composition dependence of magnetic relaxation for Co(II)(1-x)Ni(II)(x) chain-based metal-organic frameworks.

    Science.gov (United States)

    Wang, Yan-Qin; Cheng, Ai-Ling; Liu, Pei-Pei; Gao, En-Qing

    2013-08-11

    A series of isomorphous 3D Co(II)(1-x)Ni(II)(x) MOFs based on ferromagnetic chains show SCM-type slow relaxation and the Co-rich system can exhibit a higher blocking temperature than both Co(II) and Ni(II) parent materials.

  18. DNA cleavage, antibacterial, antifungal and anthelmintic studies of Co(II), Ni(II) and Cu(II) complexes of coumarin Schiff bases: Synthesis and spectral approach

    Science.gov (United States)

    Patil, Sangamesh A.; Prabhakara, Chetan T.; Halasangi, Bhimashankar M.; Toragalmath, Shivakumar S.; Badami, Prema S.

    2015-02-01

    The metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-toluidine/3-aminobenzotrifluoride. The synthesized Schiff bases and their metal complexes were structurally characterized based on IR, 1H NMR, 13C NMR, UV-visible, ESR, magnetic, thermal, fluorescence, mass and ESI-MS studies. The molar conductance values indicate that complexes are non-electrolytic in nature. Elemental analysis reveals ML2·2H2O [M = Co(II), Ni(II) and Cu(II)] stoichiometry, where 'L' stands for a singly deprotonated ligand. The presence of co-ordinated water molecules were confirmed by thermal studies. The spectroscopic studies suggest the octahedral geometry. Redox behavior of the complexes were confirmed by cyclic voltammetry. All the synthesized compounds were screened for their antibacterial (Escherichia coli, Pseudomonas auregenosa, klebsiella, Proteus, Staphylococcus aureus and salmonella) antifungal (Candida, Aspergillus niger and Rhizopus), anthelmintic (Pheretima posthuma) and DNA cleavage (Calf Thymus DNA) activity.

  19. Antimicrobial Activity of Co(II, Ni(II and Cu(II Coordination Compounds with Nitrogen, Oxygen Containing Schiff Base

    Directory of Open Access Journals (Sweden)

    B. K. RAI

    2013-06-01

    Full Text Available A series of complexes of the type [M(EHPQH2X2] where M = Co(II, Ni(II and Cu(II, EHPQH=2-ethyl, [3(hydroxypropyl]-3, 1 4H quinazoline -4-hydrazone, X= Cl-, Br-, I- and No-3 -. The geometry of the complexes have been elucidated in the light of molar mass, elemental analysis, IR, electronic Spectra, molar conductance and magnetic susceptibility. The measured molar conductance value indicates that the complexes are nonelectrolytic in nature. The above observation indicates that Schiff bases EHPQH behave as bidentate ligand and coordination proposes through azomethine N and oxygen atom of alcoholic group of ligand. The remaining coordination sites are satisfied by negative ion such as Ci-, Br-, I- and NB-. The geometry of the Co(II and Ni(II were proposed to be octahedral in geometry whereas Cu(II complexes were proposed to be distorted octahedral. The Schiff bases and its complexes have been evaluated for their antibacterial activity. The complexes show enhanced antibacterial activity than ligand.

  20. DNA cleavage, antibacterial, antifungal and anthelmintic studies of Co(II), Ni(II) and Cu(II) complexes of coumarin Schiff bases: synthesis and spectral approach.

    Science.gov (United States)

    Patil, Sangamesh A; Prabhakara, Chetan T; Halasangi, Bhimashankar M; Toragalmath, Shivakumar S; Badami, Prema S

    2015-02-25

    The metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-toluidine/3-aminobenzotrifluoride. The synthesized Schiff bases and their metal complexes were structurally characterized based on IR, (1)H NMR, (13)C NMR, UV-visible, ESR, magnetic, thermal, fluorescence, mass and ESI-MS studies. The molar conductance values indicate that complexes are non-electrolytic in nature. Elemental analysis reveals ML2·2H2O [M = Co(II), Ni(II) and Cu(II)] stoichiometry, where 'L' stands for a singly deprotonated ligand. The presence of co-ordinated water molecules were confirmed by thermal studies. The spectroscopic studies suggest the octahedral geometry. Redox behavior of the complexes were confirmed by cyclic voltammetry. All the synthesized compounds were screened for their antibacterial (Escherichia coli, Pseudomonas auregenosa, klebsiella, Proteus, Staphylococcus aureus and salmonella) antifungal (Candida, Aspergillus niger and Rhizopus), anthelmintic (Pheretima posthuma) and DNA cleavage (Calf Thymus DNA) activity.

  1. Microwave Synthesis and Antimicrobial Activity of some Copper (II, Cobalt (II, Nickel (II and Chromium (III Complexes with Schiff Base 2, 6-Pyridinedi carboxaldehyde-Thiosemicarbazone

    Directory of Open Access Journals (Sweden)

    Dr.Mohammed.Fakruddin Ali Ahmed

    2014-03-01

    Full Text Available Some novel Schiff base metal complexes of Cr(III, Co(II, Ni(II andCu(II derived from 2, 6-pyridinedicarboxaldehyde-Thiosemicarbazone(PDCTC was synthesized by conventional as well as microwavemethods. This compound wascharacterized by elemental analysis, FT-IR, Mass, molar conductanceand magneticsusceptibilitymeasurements analyses. Analytical data revealed that all the complexesexhibited 1:1 (metal: ligand ratio with a coordination number of six.The IR data showed that the ligand coordinates with the metal ions in ahexa-dentate manner. The solid state electricalconductivity of the metal complexes was also measured. Solid state electricalconductivity studies reflected a semi-conducting nature of the complexes. The Schiff base and metal complexes displayed good activity againstthe Gram-positive bacteria Staphylococcus aureus, the Gram-negative bacteriaEscherichia coli and the fungi AspergillusnigerandCandida albicans. The antimicrobialresults also indicated that the metal complexes displayed betterantimicrobial activity as compared to the Schiff bases.

  2. Syntheses, crystallographic, mass-spectroscopic determination and antioxidant studies of Co(II), Ni(II) and Cu(II) complexes of a new imidazol based Schiff base.

    Science.gov (United States)

    Demir, Serkan; Güder, Aytaç; Yazıcılar, Turan K; Çağlar, Sema; Büyükgüngör, Orhan

    2015-01-01

    A new imidazole-based Schiff base, 2-((1H-imidazol-4-yl)methyleneamino)benzylalcohol (HL) and corresponding analogous bis(2-((1H-imidazol-4-yl)methyleneimino)benzylalcohol)metal(II) perchlorates (M: Co(1), Ni(2), Cu(3)) have prepared and characterized by elemental analyses, ESI-MS, IR, UV-Vis spectroscopies and conductivity measurements. X-ray single crystal structures of 1 and 2 have been also determined. Elemental analyses, spectroscopic and conductance data of 3 demonstrated similar structural features with these of crystallographically characterized complexes and based upon this relevances, HL ligands are neutrally coordinated to metal(II) ions in tridentate mode and all complexes are isostructural, dicathionic, contain perchlorate anions as complementary ions and, are in octahedral geometry with the formulae of [M(HL)2](ClO4)2 (for 3) and [M(HL)2](ClO4)2·H2O (for 1 and 2). Radical scavenging activities of the complexes have been evaluated by using DPPH, DMPD(+), and ABTS(+) assays. SC50 values (μg/mL) of the complexes and standards on DPPH, DMPD(+), ABTS(+) follow the sequences, BHA (9.06±0.33)>CMPD3 (15.62±0.52)>CMPD2 (17.43±0.29)>Rutin (21.65±0.60)>CMPD1 (25.67±0.51)>Trolox (28.57±0.37), Rutin>BHA>CMPD3>CMPD2>Trolox>CMPD1, and Trolox>BHA>CMPD3>CMPD2>Rutin>CMPD1 respectively. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Synthesis, spectroscopic, molecular structure, antioxidant, antimicrobial and antitumor behavior of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of O2N type tridentate chromone-2-carboxaldehyde Schiff's base ligand

    Science.gov (United States)

    Ammar, Reda A.; Alaghaz, Abdel-Nasser M. A.; Zayed, Mohamed E.; Al-Bedair, Lamia A.

    2017-08-01

    Tridentate Schiff's base (HL) ligand was synthesized via condensation of salicylaldehyde and 3-hydroxypyridin-2-yliminomethyl-4H-chromen-4-one and their corresponding Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. The isolated solid complexes were characterized by elemental analyses, molar conductance, spectral (IR, UV-Vis, 1H NMR), magnetic moment, EPR, and thermal measurements. The IR spectra showed that HL was coordinated to the metal ions in tridentate manner with O2N donor sites of the azomethine N, deprotonated phenolic-OH and carbonyl-O. The activation of thermodynamic parameters are calculated using Coast-Redfern and Horowitz-Metzger (HM). The octahedral geometry of the complexes is confirmed using DFT method from DMOL3 calculations, UV-Vis and magnetic moment measurements, ESR and ligand field parameters. Antioxidant activities have also been performed for all the compounds. The investigated ligand and metal complexes were screened for their in-vitro antimicrobial activities against different types of fungal and bacterial strains. The resulting data assert on the inspected compounds as a highly promising bactericides and fungicides. The antitumor activities of all inspected compounds were evaluated towards human liver Carcinoma (HepG2) cell line.

  4. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON MIXED LIGAND COMPLEXES OF CO (II, NI (II AND CU (II WITH ISOXAZOLE SCHIFF BASE AND 1, 10-PHENANTHROLINE/ 2, 2' -BIPYRIDINE LIGANDS Synthese, Charakterisierung und antimikrobiellen STUDIES ON MIXED Ligand-Komplexe von Co (II, Ni (II und Cu (II MIT Isoxazol SCHIFF BASE AND 1, 10-Phenanthrolin / 2, 2 '-Bipyridin-Liganden

    Directory of Open Access Journals (Sweden)

    R.Shakru, N.J.P.Subhashini, Shivaraj

    2011-08-01

    Full Text Available Synthesis, Characterization and antimicrobial studies of Cobalt (II, Nickel (II and Copper (II ternary complexes of mixed ligands with Schiff base derived from 3-amino 5-methyl isoxazole with 2-hydroxy 1-naphthaldehyde and 1, 10-phenanthroline/ 2, 2' bipyridine. The micro analytical, magnetic moment, IR and electronic spectral data analysis have been used to confirm the structure of these complexes, their lower electrical conductance values indicates that all the complexes are non- electrolytes. The magnetic moment values and electronics spectral data of the Co (II and Ni (II complexes further indicates the octahedral geometry and Cu (II complexes are tetragonal geometry. The synthesized compounds have been tested against microorganisms such as (bacillus and pseudomonas bacteria and (R.Saloni and A. niger fungi. A comparative study of the MIC (minimum inhibitory concentration values of the ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligand and control.

  5. Synthesis and characterization of transition metal(II) complexes with tridentate schiff base in DMF solution

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jeong Geun [Seonam Univ., Namwon (Korea, Republic of); Choi, Yong Kook [Cheonnam National Univ., Kwangju (Korea, Republic of)

    1999-10-01

    Shiff Base ligand such as (NOIPH) have been synthesized from 2-hydroxy-1naph-thaldehyde and arometic amine, Co(II), Ni(II), and Cu(II) complexes from the reaction metal salts with Tridentate Schiff Base (NOIPH) were synthesized. The ligand and metal(II) complexes were characterized by the elementary analysis, IR, UV-Vis, NMR spectra, and thermogravimetric analysis. Metal(II) complexes in solid state have been shown that the mole ratio of Schiff base (NOIPH) as N{sub 2}O type to Metal(II) is 2:1 and the metal(II) complexes of N{sub 2}O ligand type were four-coordinated configurations.

  6. Synthesis, characterization, spectroscopic and theoretical studies of new zinc(II), copper(II) and nickel(II) complexes based on imine ligand containing 2-aminothiophenol moiety

    Science.gov (United States)

    Shafaatian, Bita; Mousavi, S. Sedighe; Afshari, Sadegh

    2016-11-01

    New dimer complexes of zinc(II), copper(II) and nickel(II) were synthesized using the Schiff base ligand which was formed by the condensation of 2-aminothiophenol and 2-hydroxy-5-methyl benzaldehyde. This tridentate Schiff base ligand was coordinated to the metal ions through the NSO donor atoms. In order to prevent the oxidation of the thiole group during the formation of Schiff base and its complexes, all of the reactions were carried out under an inert atmosphere of argon. The X-ray structure of the Schiff base ligand showed that in the crystalline form the SH groups were oxidized to produce a disulfide Schiff base as a new double Schiff base ligand. The molar conductivity values of the complexes in dichloromethane implied the presence of non-electrolyte species. The fluorescence properties of the Schiff base ligand and its complexes were also studied in dichloromethane. The products were characterized by FT-IR, 1H NMR, UV/Vis spectroscopies, elemental analysis, and conductometry. The crystal structure of the double Schiff base was determined by single crystal X-ray diffraction. Furthermore, the density functional theory (DFT) calculations were performed at the B3LYP/6-31G(d,p) level of theory for the determination of the optimized structures of Schiff base complexes.

  7. Synthesis, characterization, in vitro antimicrobial and DNA cleavage studies of Co(II), Ni(II) and Cu(II) complexes with ONOO donor coumarin Schiff bases

    Science.gov (United States)

    Patil, Sangamesh A.; Unki, Shrishila N.; Kulkarni, Ajaykumar D.; Naik, Vinod H.; Badami, Prema S.

    2011-01-01

    A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized with Schiff bases derived from 2-hydroxy-1-naphthaldehyde and 2-oxo-2H-chromene-3-carbohydrazide/6-bromo-2-oxo-2H-chromene-3-carbohydrazide. The chelation of the complexes has been proposed in the light of analytical, spectral (IR, UV-Vis, 1H NMR, ESR, FAB-mass and fluorescence), magnetic and thermal studies. The measured molar conductance values indicate that, the complexes are non-electrolytic in nature. The redox behavior of the complexes was investigated with electrochemical method by using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for their in vitro antibacterial ( Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal activities ( Candida albicans, Cladosporium and Aspergillus niger) by MIC method. The DNA cleavage is studied by agarose gel electrophoresis method.

  8. Synthesis, spectral, thermal and magnetic studies of Mn(II), Ni(II) and Cu(II) complexes with some benzopyran-4-one Schiff bases.

    Science.gov (United States)

    el-Ansary, Aida L; Abdel-Fattah, Hussein M; Abdel-Kader, Nora S

    2011-08-01

    The Schiff bases of N(2)O(2) dibasic ligands, H(2)La and H(2)Lb are prepared by the condensation of ethylenediamine (a) and trimethylenediamine (b) with 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one. Also tetra basic ligands, H(4)La and H(4)Lb are prepared by the condensation of aliphatic amines (a) and (b) with 6-formyl-5,7-dihydroxy-2-methylbenzopyran-4-one. New complexes of H(4)La and H(4)Lb with metal ions Mn(II), Ni(II) and Cu(II) are synthesized, in addition Mn(II) complexes with ligands H(2)La and H(2)Lb are also synthesized. Elemental and thermal analyses, infrared, ultraviolet-visible as well as conductivity and magnetic susceptibility measurements are used to elucidate the structure of the newly prepared metal complexes. The structures of copper(II) complexes are also assigned based upon ESR spectra study. All the complexes separated with the stoichiometric ratio (1:1) (M:L) except Mn-H(4)La and Mn-H(4)Lb with (2:1) (M:L) molar ratio. In metal chelates of the type 1:1 (M:L), the Schiff bases behave as a dinegative N(2)O(2) tetradentate ligands. Moreover in 2:1 (M:L) complexes, the Schiff base molecules act as mono negative bidentate ligand and binuclear complex is then formed. The Schiff bases were assayed by the disc diffusion method for antibacterial activity against Staphylococcus aureus and Escherichia coli. The antifungal activity of the Schiff bases was also evaluated against the fungi Aspergillus flavus and Candida albicans.

  9. NOAA Next Generation Radar (NEXRAD) Level II Base Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level II weather radar data collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska, Hawaii,...

  10. Binuclear Cu(II and Co(II Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine

    Directory of Open Access Journals (Sweden)

    Omar Hamad Shihab Al-Obaidi

    2012-01-01

    Full Text Available New binuclear Co(II and Co(II complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points. It has been found that the Schiff bases with Cu(II or Co(II ion forming binuclear complexes on (1 : 1 “metal : ligand” stoichiometry. The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolytic nature for all prepared complexes. Distorted octahedral environment is suggested for metal complexes. A theoretical treatment of the formation of complexes in the gas phase was studied, and this was done by using the HyperChem-6 program for the molecular mechanics and semi-empirical calculations. The free ligand and its complexes have been tested for their antibacterial activities against two types of human pathogenic bacteria: the first type (Staphylococcus aureus is Gram positive and the second type (Escherichia coli is Gram negative (by using agar well diffusion method. Finally, it was found that compounds show different activity of inhibition on growth of the bacteria.

  11. Tetra- and hexadentate Schiff base ligands and their Ni(II), Cu(II) and Zn(II) complexes. Synthesis, spectral, magnetic and thermal studies.

    Science.gov (United States)

    Ismail, Tarek M A; Saleh, Akila A; El Ghamry, Mosad A

    2012-02-01

    Tetradentate N(2)O(2), N(4) Schiff bases, 1,2-bis(4-oxopent-2-ylideneamino) benzene (BOAB), 1-(4-oxopent-2-ylideneamino-2-[(2-hydroxyphenyl)ethylideneamino] benzene (OAHAB), 7,16-bis(4-chlorobenzylidene)-6,8,15,17-tetra-methyl-7,16-dihydro -5,9,14,18-tetraza-dibenzo[a,h] cyclo tetradecene (BCBDCT), 7,16-bis(2-hydroxy-benzylidene)-6,8,15,17-tetramethyl-7,16-dihydro-5,9,14,18-tetraza-dibenzo [a,h] cyclo tetradecene (BHBDCT) and hexadentate N(4)O(2) Schiff bases, 2,4-bis {2-[1-(2-hydroxyphenyl) ethylideneamino] phenylimino}-3-(2-hydroxybenzylidene) pentane (BHAPHP), 2,4-bis {2-[1-(2-hydroxyphenyl) ethylideneamino] phenylimino}-3-(4-chlorobenzylidene) pentane (BHAPCP) were prepared and characterized by elemental analysis, IR, UV-Vis, (1)H NMR and mass spectra. The solid complexes of the prepared Schiff base ligands with Ni(II), Cu(II) and Zn(II) ions were isolated and characterized by elemental and thermal analyses, IR, electronic and ESR spectra as well as conductance and magnetic susceptibility measurements. The results showed that most complexes have octahedral geometry but few can attain the tetrahedral arrangement. The TG analyses suggest high stability for most complexes followed by thermal decomposition in different steps. The kinetic and thermodynamic parameters for decomposition steps in Cu(II) complexes thermograms have been calculated.

  12. Synthesis, Characterization and Biological Properties of Tridentate NNO, NNS and NNN Donor Thiazole-Derived Furanyl, Thiophenyl and Pyrrolyl Schiff Bases and Their Co(II), Cu(II), Ni(II) and Zn(II) Metal Chelates.

    Science.gov (United States)

    Chohan, Z H; Kausar, S

    2000-01-01

    2-Aminothiazole undergoes condensation reactions with furane-, thiophene- and pyrrole-2-carboxylaldehyde to give tridentate NNO, NNS and NNN Schiff bases respectively. These tridentate Schiff bases formed complexes of the type [M (L)(2)]X(2) where [M=Co(II), Cu(II), Ni(II) or Zn(II), L=N-(2-furanylmethylene)-2-aminothiazole (L(1)), N-(2-thiophenylmethylene)-2-aminothiazole (L(2), N-(2-pyrrolylmethylene)-2-aminothiazole (L(3)) and X=Cl. The structures of these Schiff bases and of their complexes have been determined on the basis of their physical, analytical and spectral data. The screening results of these compounds indicated them to possess excellent antibacterial activity against tested pathogenic bacterial organisms e.g., Escherichia coli, Staphylococcus aureous and Pseudomonas aeruginosa. However, in comparison, their metal chelates have been shown to possess more antibacterial activity than the uncomplexed Schiff bases.

  13. Cyclam-based "clickates": homogeneous and heterogeneous fluorescent sensors for Zn(II).

    Science.gov (United States)

    Tamanini, Emiliano; Flavin, Kevin; Motevalli, Majid; Piperno, Silvia; Gheber, Levi A; Todd, Matthew H; Watkinson, Michael

    2010-04-19

    In an effort to improve upon the recently reported cyclam based zinc sensor 1, the "click"-generated 1,8-disubstituted analogue 2 has been prepared. The ligand shows a 2-fold increase in its fluorescence emission compared to 1 exclusively in the presence of Zn(II) that is typical of switch-on PET fluorescent sensors. Single crystal X-ray diffraction of complexes of model ligand 10 reveals that the configuration adopted by the macrocyclic framework is extremely sensitive to the metal ion to which it coordinates. For Zn(II), Mg(II), and Li(I) the metal ions adopt an octahedral geometry with a trans III configuration of the cyclam ring. In contrast for Ni(II) the ligand adopts the rare cis V configuration, while for Cu(II) a clear preference for five-coordinate geometry is displayed with a trans I configuration of the macrocyclic ring being observed in two essentially isostructural compounds prepared via different routes. The ligand displays an increased selectivity for Zn(II) compared to 1 in the majority of cases with excellent selectivity upheld over Na(I), Mg(II), Ca(II), Mn(II), Ni(II), Co(II), and Fe(III). In contrast for Cu(II) and Hg(II) little improvement was observed for 2 compared to 1 and for Cd(II) the selectivity of the new ligand was inferior. In the light of these findings and the slower response times for ligand 2, our original "click"-generated cyclam sensor system 1 was employed in a proof of concept study to prepare a heterogeneous sol-gel based material which retains its PET response to Zn(II). The versatile nature of the sol-gel process importantly allows the simple preparation of a variety of nanostructured materials displaying high surface area-volume ratio using fabrication methods such as soft lithography, electrospinning, and nanopipetting.

  14. Binuclear cobalt(II), nickel(II), copper(II) and palladium(II) complexes of a new Schiff-base as ligand: synthesis, structural characterization, and antibacterial activity.

    Science.gov (United States)

    Geeta, B; Shravankumar, K; Reddy, P Muralidhar; Ravikrishna, E; Sarangapani, M; Reddy, K Krishna; Ravinder, V

    2010-11-01

    A binucleating new Schiff-base ligand with a phenylene spacer, afforded by the condensation of glycyl-glycine and o-phthalaldehyde has been served as an octadentate N₄O₄ ligand in designing some binuclear complexes of cobalt(II), nickel(II), copper(II), and palladium(II). The binding manner of the ligand to the metal and the composition and geometry of the metal complexes were examined by elemental analysis, conductivity measurements, magnetic moments, IR, ¹H, ¹³C NMR, ESR and electronic spectroscopies, and TGA measurements. There are two different coordination/chelation environments present around two metal centers of each binuclear complex. The composition of the complexes in the coordination sphere was found to be [M₂(L)(H(2)O)₄] (where M=Co(II) and Ni(II)) and [M₂(L)] (where M=Cu(II) and Pd(II)). In the case of Cu(II) complexes, ESR spectra provided further information to confirm the binuclear structure and the presence of magnetic interactions. All the above metal complexes have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria.

  15. Synthesis, characterization and biological activities of Cu(II), Co(II), Mn(II), Fe(II), and UO2(VI) complexes with a new Schiff Base hydrazone: O-hydroxyacetophenone-7-chloro-4-quinoline hydrazone.

    Science.gov (United States)

    Al-Shaalan, Nora H

    2011-10-13

    The Schiff base hydrazone ligand HL was prepared by the condensation reaction of 7-chloro-4-quinoline with o-hydroxyacetophenone. The ligand behaves either as monobasic bidentate or dibasic tridentate and contain ONN coordination sites. This was accounted for be the presence in the ligand of a phenolic azomethine and imine groups. It reacts with Cu(II), Ni(II), Co(II), Mn(II), UO(2) (VI) and Fe(II) to form either mono- or binuclear complexes. The ligand and its metal complexes were characterized by elemental analyses, IR, NMR, Mass, and UV-Visible spectra. The magnetic moments and electrical conductance of the complexes were also determined. The Co(II), Ni(II) and UO(2) (VI) complexes are mononuclear and coordinated to NO sites of two ligand molecules. The Cu(II) complex has a square-planar geometry distorted towards tetrahedral, the Ni(II) complex is octahedral while the UO(2) (VI) complex has its favoured heptacoordination. The Co(II), Mn(II) complexes and also other Ni(II) and Fe(III) complexes, which were obtained in the presence of Li(OH) as deprotonating agent, are binuclear and coordinated via the NNNO sites of two ligand molecules. All the binuclear complexes have octahedral geometries and their magnetic moments are quite low compared to the calculated value for two metal ions complexes and thus antiferromagnetic interactions between the two adjacent metal ions. The ligand HL and metal complexes were tested against a strain of Gram +ve bacteria (Staphylococcus aureus), Gram -ve bacteria (Escherichia coli), and fungi (Candida albicans). The tested compounds exhibited high antibacterial activities.

  16. Synthesis, Characterization and Biological Activities of Cu(II, Co(II, Mn(II, Fe(II, and UO2(VI Complexes with a New Schiff Base Hydrazone: O-Hydroxyacetophenone-7-chloro-4-quinoline Hydrazone

    Directory of Open Access Journals (Sweden)

    Nora H. Al-Shaalan

    2011-10-01

    Full Text Available The Schiff base hydrazone ligand HL was prepared by the condensation reaction of 7-chloro-4-quinoline with o-hydroxyacetophenone. The ligand behaves either as monobasic bidentate or dibasic tridentate and contain ONN coordination sites. This was accounted for be the presence in the ligand of a phenolic azomethine and imine groups. It reacts with Cu(II, Ni(II, Co(II, Mn(II, UO2 (VI and Fe(II to form either mono- or binuclear complexes. The ligand and its metal complexes were characterized by elemental analyses, IR, NMR, Mass, and UV-Visible spectra. The magnetic moments and electrical conductance of the complexes were also determined. The Co(II, Ni(II and UO2 (VI complexes are mononuclear and coordinated to NO sites of two ligand molecules. The Cu(II complex has a square-planar geometry distorted towards tetrahedral, the Ni(II complex is octahedral while the UO2 (VI complex has its favoured heptacoordination. The Co(II, Mn(II complexes and also other Ni(II and Fe(III complexes, which were obtained in the presence of Li(OH as deprotonating agent, are binuclear and coordinated via the NNNO sites of two ligand molecules. All the binuclear complexes have octahedral geometries and their magnetic moments are quite low compared to the calculated value for two metal ions complexes and thus antiferromagnetic interactions between the two adjacent metal ions. The ligand HL and metal complexes were tested against a strain of Gram +ve bacteria (Staphylococcus aureus, Gram −ve bacteria (Escherichia coli, and fungi (Candida albicans. The tested compounds exhibited high antibacterial activities.

  17. Mesogenic copper(II) complexes with [1,2,3]-triazole-based bidentate Schiff bases

    Indian Academy of Sciences (India)

    Guan-Yeow Yeap; Boon-Teck Heng

    2014-01-01

    The first mesogenic Cu(II) complex with [1,2,3]-triazole-based bidentate Schiff bases with flexible terminal alkyl chain, CnH2n+1 (even parity of n = 10-18) has been successfully synthesized. The heterocyclic triazole core was introduced into the target compound through the click reaction between azidoalkane and propargyl aldehyde. All the uncoordinated ligands and target complexes were characterized by elemental analysis, FT-IR, 1H-NMR and UV-visible spectroscopic techniques. The observation under the polarized light and differential scanning calometry (DSC) shows that the triazole-based ligands exhibit unstable SmA phase which are not reproducible upon subsequent heating and cooling. Interestingly, the whole homologues of Cu(II) complexes show exclusively stable focal conic fan-shaped texture characteristic of SmA phase. This can be ascribed to the presence of Cu-N and Cu-O coordination modes which enhance the collinearity and molecular anisotropy. On the other hand, the Cu(II) complexes are thermally more stable as compared to their corresponding ligands.

  18. Syntheses, characterizations and structures of NO donor Schiff base ligands and nickel(II) and copper(II) complexes

    Science.gov (United States)

    Şenol, Cemal; Hayvali, Zeliha; Dal, Hakan; Hökelek, Tuncer

    2011-06-01

    New Schiff base derivatives ( L 1 and L 2) were prepared by the condensation of 2-hydroxy-3-methoxybenzaldehyde ( o-vanillin) and 3-hydroxy-4-methoxybenzaldehyde ( iso-vanillin) with 5-methylfurfurylamine. Two new complexes [Ni(L 1) 2] and [Cu(L 1) 2] have been synthesized with bidentate NO donor Schiff base ligand ( L 1). The Ni(II) and Cu(II) atoms in each complex are four coordinated in a square planar geometry. Schiff bases ( L 1 and L 2) and complexes [Ni(L 1) 2] and [Cu(L 1) 2] were characterized by elemental analyses, FT-IR, UV-vis, mass and 1H, 13C NMR spectroscopies. The crystal structures of the ligand ( L 2) and complexes [Ni(L 1) 2] and [Cu(L 1) 2] have also been determined by using X-ray crystallographic technique.

  19. New macrocyclic schiff base complexes incorporating a homopiperazine unit: Synthesis of some Co(II), Ni(II),Cu(II) and Zn(II) complexes and crystal structure and theoretical studies

    Science.gov (United States)

    Keypour, Hassan; Rezaeivala, Majid; Ramezani-Aktij, Ameneh; Bayat, Mehdi; Dilek, Nefise; Ünver, Hüseyin

    2016-07-01

    A new macrocyclic Schiff base ligand, L, was synthesized by condensation reaction of 1,4-bis(2-formylphenyl)homopiperazine and 1,4-diaminobutane in acetonitrile. The Schiff base ligand was characterized by using elemental analyses, FT-IR, 1H, 13C NMR and mass spectroscopic techniques. The metal (II) complexes [ML], were synthesized from the reaction of MCl2.nH2O (M: Co, Ni, Cu and Zn) with Schiff base ligand, L and characterized by elemental analyses and FT-IR. X-ray crystal structure of [CoLCl]+ distorted square pyramidal geometry with an N4Cl core, arising from coordination by the four donor nitrogen atoms from the macrocyclic framework and one Cl atom. It crystallizes triclinic space group, P-1 with a = 7.1777(1) Å, b = 11.0357 (2) Å, c = 15.1520(2) Å, V = 1183.14(3), Z = 2, Dc = 1.556 g cm-3, μ (MoKα) = 0.156 mm-1. Also, the bonding situation between the [MCl]+ and Ligand (L) fragments in [MLCl]ClO4 (M = Co(II), Ni(II), Cu(II), Zn(II)) complexes were carried out by energy-decomposition analysis (EDA). The results showed that there is an increasing trend in the case of ΔEelstat of the complexes by changing the M from Co(II) to Zn(II).

  20. Ternary alloys based on II-VI semiconductor compounds

    CERN Document Server

    Tomashyk, Vasyl; Shcherbak, Larysa

    2013-01-01

    Phase Equilibria in the Systems Based on ZnSSystems Based on ZnSeSystems Based on ZnTeSystems Based on CdSSystem Based on CdSeSystem Based on CdTeSystems Based on HgSSystems Based on HgSeSystems Based on HgTeIndexReferences appear at the end of each chapter.

  1. Quaternary alloys based on II-VI semiconductors

    CERN Document Server

    Tomashyk, Vasyl

    2014-01-01

    Systems Based on ZnSSystems Based on ZnSeSystems Based on ZnTeSystems Based on CdSSystems Based on CdSeSystems Based on CdTeSystems Based on HgSSystems Based on HgSeSystems Based on HgTeIndexReferences appear at the end of each chapter.

  2. Java-based Graphical User Interface for MAVERIC-II

    Science.gov (United States)

    Seo, Suk Jai

    2005-01-01

    A computer program entitled "Marshall Aerospace Vehicle Representation in C II, (MAVERIC-II)" is a vehicle flight simulation program written primarily in the C programming language. It is written by James W. McCarter at NASA/Marshall Space Flight Center. The goal of the MAVERIC-II development effort is to provide a simulation tool that facilitates the rapid development of high-fidelity flight simulations for launch, orbital, and reentry vehicles of any user-defined configuration for all phases of flight. MAVERIC-II has been found invaluable in performing flight simulations for various Space Transportation Systems. The flexibility provided by MAVERIC-II has allowed several different launch vehicles, including the Saturn V, a Space Launch Initiative Two-Stage-to-Orbit concept and a Shuttle-derived launch vehicle, to be simulated during ascent and portions of on-orbit flight in an extremely efficient manner. It was found that MAVERIC-II provided the high fidelity vehicle and flight environment models as well as the program modularity to allow efficient integration, modification and testing of advanced guidance and control algorithms. In addition to serving as an analysis tool for techno logy development, many researchers have found MAVERIC-II to be an efficient, powerful analysis tool that evaluates guidance, navigation, and control designs, vehicle robustness, and requirements. MAVERIC-II is currently designed to execute in a UNIX environment. The input to the program is composed of three segments: 1) the vehicle models such as propulsion, aerodynamics, and guidance, navigation, and control 2) the environment models such as atmosphere and gravity, and 3) a simulation framework which is responsible for executing the vehicle and environment models and propagating the vehicle s states forward in time and handling user input/output. MAVERIC users prepare data files for the above models and run the simulation program. They can see the output on screen and/or store in

  3. Relative Leukocyte Telomere Length, Hematological Parameters and Anemia - Data from the Berlin Aging Study II (BASE-II).

    Science.gov (United States)

    Meyer, Antje; Salewsky, Bastian; Buchmann, Nikolaus; Steinhagen-Thiessen, Elisabeth; Demuth, Ilja

    2016-01-01

    The length of the chromosome ends, telomeres, is widely accepted as a biomarker of aging. However, the dynamic of the relationship between telomere length and hematopoietic parameters in the normal aging process, which is of particular interest with respect to age-related anemia, is not well understood. We have analyzed the relationship between relative leukocyte telomere length (rLTL) and several hematological parameters in the older group of the Berlin Aging Study II (BASE-II) participants. This paper also compares rLTL between both BASE-II age groups (22-37 and 60-83 years). Genomic DNA was extracted from peripheral blood leukocytes of BASE-II participants and used to determine rLTL by a quantitative PCR protocol. Standard methods were used to determine blood parameters, and the WHO criteria were used to identify anemic participants. Telomere length data were available for 444 younger participants (28.4 ± 3.1 years old; 52% women) and 1,460 older participants (68.2 ± 3.7 years old; 49.4% women). rLTL was significantly shorter in BASE-II participants of the older group (p = 3.7 × 10-12) and in women (p = 4.2 × 10-31). rLTL of older men exhibited a statistically significant, positive partial correlation with mean corpuscular hemoglobin (MCH; p = 0.012) and MCH concentration (p = 0.002). While these correlations were only observed in men, the rLTL of older women was negatively correlated with the number of thrombocytes (p = 0.015) in the same type of analysis. Among all older participants, 6% met the criteria to be categorized as 'anemic'; however, there was no association between anemia and rLTL. In the present study, we have detected isolated correlations between rLTL and hematological parameters; however, in all cases, rLTL explained only a small part of the variation of the analyzed parameters. In disagreement with some other studies showing similar data, we interpret the association between rLTL and some of the hematological parameters studied here to be

  4. Chemical modification of silica gel with synthesized new Schiff base derivatives and sorption studies of cobalt (II) and nickel (II)

    Energy Technology Data Exchange (ETDEWEB)

    Kursunlu, Ahmed Nuri, E-mail: ankursunlu@gmail.com [Department of Chemistry, Selcuk University, Campus, 42075, Konya (Turkey); Guler, Ersin; Dumrul, Hakan; Kocyigit, Ozcan; Gubbuk, Ilkay Hilal [Department of Chemistry, Selcuk University, Campus, 42075, Konya (Turkey)

    2009-08-15

    In this study, three Schiff base ligands and their complexes were synthesized and characterized by infrared spectroscopy (IR), thermogravimetric analyses (TGA), nuclear magnetic resonance (NMR), elemental analysis and magnetic susceptibility apparatuses. Silica gel was respectively modified with Schiff base derivatives, (E)-2-[(2-chloroethylimino)methyl]phenol, (E)-4-[(2-chloroethylimino)methyl]phenol and N,N'-[1,4-phenilendi(E)methylidene]bis(2-chloroethanamine), after silanization of silica gel by (3-aminopropyl)trimethoxysilane (APTS) by using a suitable method. Characterization of the surface modification was also performed with IR, TGA and elemental analysis. The immobilized surfaces were used for Co(II) and Ni(II) sorption from aqueous solutions and values of sorption were detected by atomic absorption spectrometer (AAS).

  5. Cu(II) and Pd(II) complexes of water soluble O-carboxymethyl chitosan Schiff bases: Synthesis, characterization.

    Science.gov (United States)

    Baran, Talat; Menteş, Ayfer

    2015-08-01

    This study reports the synthesis of two new water soluble O-carboxymethyl chitosan Schiff bases (OCMCS-5 and OCMCS-6a) and their Cu(II) and Pd(II) complexes. Characterizations of these complexes were carried out with FTIR, elemental analysis, (13)C CPMAS, UV-vis, magnetic moment and molar conductivity techniques. The degrees of substitution (DS) for OCMCS-5a and OCMCS-6a were determined to be 0.48 and 0.44 in elemental analysis. The solubility test revealed that OCMCS-5a and OCMCS-6a dissolved thoroughly in water. The surface morphologies of chitosan (CS), OCMCS-5a, OCMCS-6a and their complexes were studied with SEM-EDAX. Thermal stability of the synthesized compounds was evaluated by TG/DTG and their crystallinity values were investigated with powder X-ray diffraction. Cu(II) and Pd(II) contents of the complexes were estimated with ICP-OES. The characterization studies demonstrated that the thermal stability and crystallinity values of the OCMCS-5a and OCMCS-6a were lower than those of CS.

  6. Synthesis, characterization and biological activity of Cu(II), Ni(II) and Zn(II) complexes of biopolymeric Schiff bases of salicylaldehydes and chitosan.

    Science.gov (United States)

    de Araújo, Eliene Leandro; Barbosa, Hellen Franciane Gonçalves; Dockal, Edward Ralph; Cavalheiro, Éder Tadeu Gomes

    2017-02-01

    Schiff bases have been prepared from biopolymer chitosan and salicylaldehyde, 5-methoxysalicylaldehyde, and 5-nitrosalicylaldehyde. Ligands were synthesized in a 1:1.5mol ratio, and their Cu(II), Ni(II) and Zn(II) complexes in a 1:1mol ratio (ligand:metal). Ligands were characterized by (1)H NMR and FTIR, resulting in degrees of substitution from 43.7 to 78.7%. Complexes were characterized using FTIR, electronic spectra, XPRD. The compounds were confirmed by the presence of an imine bond stretching in the 1630-1640cm(-1) and νMetal-N and νMetal-O at Schiff base complexes presented lower thermal stability and crystallinity than the starting chitosan. Residues were the metallic oxides as confirmed by XPRD, whose amounts were used in the calculation of the percentage of complexed metal ions. Surface morphologies were analyzed with SEM-EDAX. Preliminary cytotoxicity tests were performed using MTT assay with HeLa cells. Despite the differences in solubility, the free bases presented relatively low toxicity.

  7. Transition Metal(II Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies

    Directory of Open Access Journals (Sweden)

    Aurora Reiss

    2014-01-01

    Full Text Available New [ML2(H2O2] complexes, where M = Co(II, Ni(II, Cu(II, and Zn(II while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehyde in situ in the presence of divalent metal salts in ethanolic medium. The complexes were characterized by elemental analyses, conductance, and magnetic measurements, as well as by IR and UV-Vis spectroscopy. The low values of the molar conductance indicate nonelectrolyte type of complexes. Based on spectral data and magnetic moments, an octahedral geometry may be proposed for Co(II, Ni(II, and Zn(II complexes while a tetragonal geometry for Cu(II complex. Molecular structure of the Schiff base ligand and its complexes were studied using programs dedicated to chemical modeling and quantomolecular calculation of chemical properties. All the synthesized complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.

  8. Impact of Gadget Based Learning of Grammar in English at Standard II

    Science.gov (United States)

    Singaravelu, G.

    2014-01-01

    The study enlightens the impact of Gadget Based Learning of English Grammar at standard II. Objectives of the study is to find out the learning problems of the students of standard II in Learning English Grammar in Shri Vani Vilas Middle School and to find whether there is any significant difference in achievement mean score between pre test of…

  9. Biphenolate Iron (II) Complexes with Intramolecularly Coordinating Nitrogen Lewis Bases

    NARCIS (Netherlands)

    Koten, G. van; Brandts, J.A.M.; Janssen, M.D.; Hogerheide, M.P.; Boersma, J.; Spek, A.L.

    1999-01-01

    The synthesis and characterisation of a novel Fe(II) bisphenolate complex [Fe(OC{6}H{4}CH{2}NMe{2}-2){2}]{2} (1) from [Na(OC{6}H{4}CH{2}NMe{2}-2)] and anhydrous FeCl{2} is reported. The solid state structure has been elucidated by single crystal X-ray analysis and shows a dimeric structure with two

  10. Biphenolate Iron (II) Complexes with Intramolecularly Coordinating Nitrogen Lewis Bases

    NARCIS (Netherlands)

    Koten, G. van; Brandts, J.A.M.; Janssen, M.D.; Hogerheide, M.P.; Boersma, J.; Spek, A.L.

    1999-01-01

    The synthesis and characterisation of a novel Fe(II) bisphenolate complex [Fe(OC{6}H{4}CH{2}NMe{2}-2){2}]{2} (1) from [Na(OC{6}H{4}CH{2}NMe{2}-2)] and anhydrous FeCl{2} is reported. The solid state structure has been elucidated by single crystal X-ray analysis and shows a dimeric structure with two

  11. Rational assembly of Pb(II)/Cd(II)/Mn(II) coordination polymers based on flexible V-shaped dicarboxylate ligand: Syntheses, helical structures and properties

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Gao-Shan [School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063 (China); Liu, Chong-Bo, E-mail: cbliu@nchu.edu.cn [School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063 (China); School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 (United States); Liu, Hong [School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063 (China); Robbins, Julianne; Zhang, Z. John [School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 (United States); Yin, Hong-Shan [School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063 (China); Wen, Hui-Liang [State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047 (China); Wang, Yu-Hua [School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063 (China)

    2015-05-15

    Six new coordination polymers, namely, [Pb(L)(H{sub 2}O)] (1), [Pb(L)(phen)] (2), [Pb{sub 2}(L){sub 2}(4,4′-bipy){sub 0.5}] (3), [Cd(L)(phen)] (4), [Cd(L)(4,4′-bipy)]·H{sub 2}O (5) and [Mn(L)(4,4′-bipy)]·H{sub 2}O (6) have been synthesized by the hydrothermal reaction of 2,2′-[hexafluoroisopropylidenebis(p-phenyleneoxy)]diacetic acid (H{sub 2}L) with Pb(II)/Cd(II)/Mn(II) in the presence of ancillary ligands 4,4′-bipyridine (4,4′-bipy) or 1,10-phenanthroline (phen). Complexes 1 and 4–6 exhibit 2-D structures, and complexes 2–3 display 3-D frameworks, of which L{sup 2−} ligands join metal ions to single-stranded helical chains of 1, 3–6 and double-stranded helical chains of 2. Complexes 2 and 3 also contain double-stranded Metal–O helices. Topology analysis reveals that complexes 1 and 4 both represent 4-connected sql net, 2 represents 6-connected pcu net, 3 exhibits a novel (3,12)-connected net, while 5 and 6 display (3,5)-connected gek1 net. The six complexes exhibit two kinds of inorganic–organic connectivities: I{sup 0}O{sup 2} for 1, 4–6, and I{sup 1}O{sup 2} for 2–3. The photoluminescent properties of 4–5 and the magnetic properties of 6 have been investigated. - Graphical abstract: Six new Pb(II)/Cd(II)/Mn(II) coordination polymers with helical structures based on flexible V-shaped dicarboxylate ligand have been synthesized and structurally characterized. Photoluminescent and magnetic properties have been investigated. - Highlights: • Six novel M(II) coordination polymers with 2,2′-[hexafluoroisopropylidenebis(p-phenyleneoxy)]diacetic acid and N-donor ligands. • Complexes 1–6 show diverse intriguing helical characters. • The luminescent properties of complexes 1–5 were investigated. • Complex 6 shows antiferromagnetic coupling.

  12. 75 FR 52321 - Dry Lake Wind Power II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2010-08-25

    ...-1720-000] Dry Lake Wind Power II LLC; Supplemental Notice That Initial Market-Based Rate Filing... the above-referenced proceeding, of Dry Lake Wind Power II LLC application for market-based rate...

  13. High Quantum Efficiency Type II SLS FPAs for Space-Based Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR proposes to develop high quantum efficiency (QE) and low dark current infrared epitaxy materials based on Type II Strained Layer Superlattice (SLS)...

  14. Preparation and Electronic Property Investigation of Zinc(II)-Schiff Base Complexes in the Confined Space

    OpenAIRE

    Peng Shang; Lei Zhang

    2013-01-01

    Metal-Schiff base complexes have attracted continued research interest regarding their intriguing and useful features, while the electronic properties of these complexes in the confined space have not been sufficiently addressed in previous studies. In this work, a new zinc(II)-Schiff base complex bis(N-dodecyl salicylideneiminato)Zn(II) (1) was synthesized and subsequently loaded in an inorganic solid host. A large red shift (~40 nm) of the absorption onset was recorded, when the microenviro...

  15. Synthesis, characterization and antibacterial activities of Zn(II and Cd(II complexes of a quinazoline-4(3H-one Schiff base

    Directory of Open Access Journals (Sweden)

    Brahman Dhiraj

    2014-01-01

    Full Text Available Zn(II and Cd(II complexes of a Schiff base derived from quinazoline-4(3H one and 2-formylphenoxy acetic acid were prepared and characterized by elemental and different spectroscopic (IR, UV-Visible and NMR analyses. The elemental analysis indicated the formation of the complexes: [ML(AcO].H2O, where M stands for Zn(II and Cd(II and L stands for quinazoline-4(3H-one Schiff base. The molar conductivities of the prepared complexes revealed their non-electrolytic nature. The complexes were also investigated for their antimicrobial activities by using turbidometric assay method.

  16. A new Mannich base and its transition metal (II) complexes - Synthesis, structural characterization and electrochemical study

    Indian Academy of Sciences (India)

    N Raman; S Esthar; C Thangaraja

    2004-06-01

    new Mannich base, N-(1-morpholinobenzyl) semicarbazide (MBS), formed by the condensation of morpholine, semicarbazide and benzaldehyde, and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of analytical, magnetic, electrical conductivity and spectral study as well as elemental analyses. The complexes exhibit square-planar geometry. The monomeric and non-electrolytic nature of the complexes is evidenced by their magnetic susceptibility and low conductance data. The electrochemical property of the ligand and its complexes in acetonitrile solution was studied by cyclic voltammetry. The X-band ESR spectra of the Cu(II) complex in DMSO at 300 and 77 K were recorded and their salient features are reported.

  17. Selective adsorption behavior of Pb(II) by mesoporous silica SBA-15-supported Pb(II)-imprinted polymer based on surface molecularly imprinting technique

    Energy Technology Data Exchange (ETDEWEB)

    Liu Yan [School of Chemistry and Chemical Engineering, Jiangsu University, XueFu Road 201, Zhenjiang 212013 (China); Liu Zhanchao [School of Materials Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang 212013 (China); Gao Jie; Dai Jiangdong; Han Juan; Wang Yun; Xie Jimin [School of Chemistry and Chemical Engineering, Jiangsu University, XueFu Road 201, Zhenjiang 212013 (China); Yan Yongsheng, E-mail: lyan@ujs.edu.cn [School of Chemistry and Chemical Engineering, Jiangsu University, XueFu Road 201, Zhenjiang 212013 (China)

    2011-02-15

    Research highlights: {yields} The novel surface ion-imprinted polymer based on SBA-15 possessed high ordered mesoporous structure and the graft occurred on the surface of the inner channel. {yields} Kinetics parameters indicated the second-order mechanism and pore diffusion were dominant. {yields} Thermodynamic parameters indicated the adsorption process was spontaneous, exothermic and good affinity nature. {yields} Fast kinetics, high selectivity and satisfied adsorption capacity were obtained. - Abstract: In this study, a new Pb(II) ion-imprinted polymer (Pb(II)-IIP), which can be used for selective adsorption of Pb(II) from aqueous solutions, was successfully prepared based on the supported material of ordered mesoporous silica SBA-15 with the help of surface molecular imprinting technology. The prepared polymer was characterized by Fourier transmission infrared spectrometry, X-ray diffraction, transmission electron microscope and nitrogen adsorption-desorption isotherm. The results showed that the synthesized polymer possessed high ordered mesoporous structure. The adsorption behavior of the adsorbents for Pb(II) was investigated using batch experiments. The Pb(II)-IIP showed fast kinetics, high selectivity and satisfied adsorption capacity for adsorption of Pb(II). Under the optimum experimental condition, Pb(II) adsorption process over Pb(II)-IIP follows pseudo-second-order reaction kinetics and follows the Langmuir adsorption isotherm. In addition, the thermodynamic parameters calculated from the adsorption data suggested that the adsorption of Pb(II) onto Pb(II)-IIP was a spontaneous and exothermic nature of the process.

  18. Synthesis, spectral characterization thermal stability, antimicrobial studies and biodegradation of starch–thiourea based biodegradable polymeric ligand and its coordination complexes with [Mn(II, Co(II, Ni(II, Cu(II, and Zn(II] metals

    Directory of Open Access Journals (Sweden)

    Nahid Nishat

    2016-09-01

    Full Text Available A biodegradable polymer was synthesized by the modification reaction of polymeric starch with thiourea which is further modified by transition metals, Mn(II, Co(II, Ni(II, Cu(II and Zn(II. All the polymeric compounds were characterized by (FT-IR spectroscopy, 1H NMR spectroscopy, 13C NMR spectroscopy, UV–visible spectra, magnetic moment measurements, thermogravimetric analysis (TGA and antibacterial activities. Polymer complexes of Mn(II, Co(II and Ni(II show octahedral geometry, while polymer complexes of Cu(II and Zn(II show square planar and tetrahedral geometry, respectively. The TGA revealed that all the polymer metal complexes are more thermally stable than their parental ligand. In addition, biodegradable studies of all the polymeric compounds were also carried out through ASTM-D-5338-93 standards of biodegradable polymers by CO2 evolution method which says that coordination decreases biodegradability. The antibacterial activity was screened with the agar well diffusion method against some selected microorganisms. Among all the complexes, the antibacterial activity of the Cu(II polymer–metal complex showed the highest zone of inhibition because of its higher stability constant.

  19. Co(II) and Cd(II) complexes derived from heterocyclic Schiff-Bases: synthesis, structural characterisation, and biological activity.

    Science.gov (United States)

    Ahmed, Riyadh M; Yousif, Enaam I; Al-Jeboori, Mohamad J

    2013-01-01

    New monomeric cobalt and cadmium complexes with Schiff-bases, namely, N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]furan-2-carbohydrazide (L¹) and N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]thiophene-2-carbohydrazide (L²) are reported. Schiff-base ligands L¹ and L² were derived from condensation of 3-hydroxy-4-methoxybenzaldehyde (iso-vanillin) with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide, respectively. Complexes of the general formula [M(L)₂]Cl₂ (where M = Co(II) or Cd(II), L = L¹ or L²) have been obtained from the reaction of the corresponding metal chloride with the ligands. The ligands and their metal complexes were characterised by spectroscopic methods (FTIR, UV-Vis, ¹H, and ¹³C NMR spectra), elemental analysis, metal content, magnetic measurement, and conductance. These studies revealed the formation of four-coordinate complexes in which the geometry about metal ion is tetrahedral. Biological activity of the ligands and their metal complexes against gram positive bacterial strain Bacillus (G+) and gram negative bacteria Pseudomonas (G-) revealed that the metal complexes become less resistive to the microbial activities as compared to the free ligands.

  20. Azobenzene-based inhibitors of human carbonic anhydrase II

    Directory of Open Access Journals (Sweden)

    Leander Simon Runtsch

    2015-07-01

    Full Text Available Aryl sulfonamides are a widely used drug class for the inhibition of carbonic anhydrases. In the context of our program of photochromic pharmacophores we were interested in the exploration of azobenzene-containing sulfonamides to block the catalytic activity of human carbonic anhydrase II (hCAII. Herein, we report the synthesis and in vitro evaluation of a small library of nine photochromic sulfonamides towards hCAII. All molecules are azobenzene-4-sulfonamides, which are substituted by different functional groups in the 4´-position and were characterized by X-ray crystallography. We aimed to investigate the influence of electron-donating or electron-withdrawing substituents on the inhibitory constant Ki. With the aid of an hCAII crystal structure bound to one of the synthesized azobenzenes, we found that the electronic structure does not strongly affect inhibition. Taken together, all compounds are strong blockers of hCAII with Ki = 25–65 nM that are potentially photochromic and thus combine studies from chemical synthesis, crystallography and enzyme kinetics.

  1. Radiation effects on II-VI compound-based detectors

    CERN Document Server

    Cavallini, A; Dusi, W; Auricchio, N; Chirco, P; Zanarini, M; Siffert, P; Fougeres, P

    2002-01-01

    The performance of room temperature CdTe and CdZnTe detectors exposed to a radiation source can be strongly altered by the interaction of the ionizing particles and the material. Up to now, few experimental data are available on the response of II-VI compound detectors to different types of radiation sources. We have carried out a thorough investigation on the effects of gamma-rays, neutrons and electron irradiation both on CdTe : Cl and Cd sub 0 sub . sub 9 Zn sub 0 sub . sub 1 Te detectors. We have studied the detector response after radiation exposure by means of dark current measurements and of quantitative spectroscopic analyses at low and medium energies. The deep traps present in the material have been characterized by means of PICTS (photo-induced current transient spectroscopy) analyses, which allow to determine the trap apparent activation energy and capture cross-section. The evolution of the trap parameters with increasing irradiation doses has been monitored for all the different types of radiati...

  2. II-IV-V Based Thin Film Tandem Photovoltaic Cell

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Nathan [Arizona State Univ., Mesa, AZ (United States); van Schilfgaarde, Mark [Arizona State Univ., Mesa, AZ (United States)

    2012-10-04

    [Through a combination of theory and experiment that, absent unknown mitigating factors, a tandem cell whose (wide-gap. 1.8 eV) top layer is made of ZnSnP2 and whose (narrow gap, 1.1 eV) bottom layer consisting of ZnGeAs2 are near-ideal materials for a tandem cell. Not only are there gaps optimally adjusted to the solar spectrum, but the two compounds are lattice-matched, and their energy band structure and optical absorption are also near-ideal (they closely resemble that of GaAs). Our first major challenge is to establish that high-quality II-IV-V thin films can be synthesized. We have begun growing and characterizing films of ZnGeAs2 and ZnSnP2, initially grown on Ge substrates (the lattice constant of Ge matches these compounds) by pulsed laser ablation and sputtering. In tandem are theoretical calculations to guide the experiments. The goal is to develop methods that can be used to produce a pair of lattice-matched thin films that will be useful in tandem cells.

  3. Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL.

    Science.gov (United States)

    Chen, Zhiye; Li, Lin; Sun, Jie; Ma, Lin

    2012-08-01

    To investigate the pattern of brain volume changes of the brain in patients with type II diabetes mellitus using voxel-based morphometry. Institutional ethics approval and informed consent were obtained. VBM based on the high resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI images was obtained from 16 type II diabetes patients (mean age 61.2 years) and 16 normal controls (mean age 59.6 years). All images were spatially preprocessed using Diffeomorphic Anatomical Registration using Exponentiated Lie algebra (DARTEL) algorithm, and the DARTEL templates were made from 100 normal subjects. Statistical parametric mapping was generated using analysis of covariance (ANCOVA). An atrophy pattern of gray matter was seen in type II diabetes patients compared with controls that involved the right superior, middle, and inferior temporal gyri, right precentral gyrus, and left rolandic operculum region. The loss of white matter volume in type II diabetes mellitus was observed in right temporal lobe and left inferior frontal triangle region. ROI analysis revealed that the gray and white matter volume of right temporal lobe were significant lower in type II diabetes mellitus than that in controls (P<0.05). This work demonstrated that type II diabetes mellitus patients mainly exhibited gray and white matter atrophy in right temporal lobe, and this finding supported that type II diabetes mellitus could lead to subtle diabetic brain structural changes in patients without dementia or macrovascular complications. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  4. Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Zhiye [Department of Radiology, PLA General Hospital, 28 Fuxing Road, Beijing 100853 (China); Li, Lin [Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853 (China); Sun, Jie [Department of Endocrinology, PLA General Hospital, Beijing 100853 (China); Ma, Lin, E-mail: cjr.malin@vip.163.com [Department of Radiology, PLA General Hospital, 28 Fuxing Road, Beijing 100853 (China)

    2012-08-15

    Purpose: To investigate the pattern of brain volume changes of the brain in patients with type II diabetes mellitus using voxel-based morphometry. Material and methods: Institutional ethics approval and informed consent were obtained. VBM based on the high resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI images was obtained from 16 type II diabetes patients (mean age 61.2 years) and 16 normal controls (mean age 59.6 years). All images were spatially preprocessed using Diffeomorphic Anatomical Registration using Exponentiated Lie algebra (DARTEL) algorithm, and the DARTEL templates were made from 100 normal subjects. Statistical parametric mapping was generated using analysis of covariance (ANCOVA). Results: An atrophy pattern of gray matter was seen in type II diabetes patients compared with controls that involved the right superior, middle, and inferior temporal gyri, right precentral gyrus, and left rolandic operculum region. The loss of white matter volume in type II diabetes mellitus was observed in right temporal lobe and left inferior frontal triangle region. ROI analysis revealed that the gray and white matter volume of right temporal lobe were significant lower in type II diabetes mellitus than that in controls (P < 0.05). Conclusion: This work demonstrated that type II diabetes mellitus patients mainly exhibited gray and white matter atrophy in right temporal lobe, and this finding supported that type II diabetes mellitus could lead to subtle diabetic brain structural changes in patients without dementia or macrovascular complications.

  5. Polymeric material prepared from Schiff base based on O-carboxymethyl chitosan and its Cu(II) and Pd(II) complexes

    Science.gov (United States)

    Baran, Talat; Menteş, Ayfer

    2016-07-01

    In this study, a new eco-friendly Schiff base based on O-carboxymethyl chitosan ([OCMCS-7a]) and its copper(II) and palladium(II) complexes were synthesized. Characterizations of [OCMCS-7a] and its metal complexes were conducted using FTIR, 1H NMR, 13C NMR, TG/DTG, XRD, SEM-EDAX, ICP, UV-VIS, GC-MS, elemental analysis, magnetic moment and molar conductivity measurements. The degree of substitution (DS) of [OCMCS-7a] was determined by elemental analysis to be 0.44. It was shown by the solubility test that [OCMCS-7a] was completely soluble in water. Surface images of chitosan, [OCMCS-7a] and its Cu(II) and Pd(II) complexes were investigated using the SEM-EDAX technique. Their thermal behaviors and crystallinities of the synthesized complexes were determined by TG/DTG and X-ray powder diffraction techniques, respectively. The metal contents of the obtained complexes were determined using an ICP-OES instrument. From the analyses, it was noted that the thermal stabilities and crystallinities of [OCMCS-7a] and its complexes decreased compared to chitosan. As a consequence of surface screening, it was also noted that the surface structure of the chitosan was smoother than that of the obtained compounds.

  6. Profit based phase II sample size determination when adaptation by design is adopted

    OpenAIRE

    Martini, D.

    2014-01-01

    Background. Adaptation by design consists in conservatively estimating the phase III sample size on the basis of phase II data, and can be applied in almost all therapeutic areas; it is based on the assumption that the effect size of the drug is the same in phase II and phase III trials, that is a very common scenario assumed in product development. Adaptation by design reduces the probability on underpowered experiments and can improve the overall success probability of phase II and III tria...

  7. Electrochemical studies of DNA interaction and antimicrobial activities of MnII, FeIII, CoII and NiII Schiff base tetraazamacrocyclic complexes

    Science.gov (United States)

    Kumar, Anuj; Vashistha, Vinod Kumar; Tevatia, Prashant; Singh, Randhir

    2017-04-01

    Tetraazamacrocyclic complexes of MnII, FeIII, CoII and NiII have been synthesized by template method. These tetraazamacrocycles have been analyzed with various techniques like molar conductance, IR, UV-vis, mass spectral and cyclic voltammetric studies. On the basis of all these studies, octahedral geometry has been assigned to these tetraazamacrocyclic complexes. The DNA binding properties of these macrocyclic complexes have been investigated by electronic absorption spectra, fluorescence spectra, cyclic voltammetric and differential pulse voltammetric studies. The cyclic voltammetric data showed that ipc and ipa were effectively decreased in the presence of calf thymus DNA, which is a strong evidence for the interaction of these macrocyclic complexes with the calf thymus DNA (ct-DNA). The heterogeneous electron transfer rate constant found in the order: KCoII > KNiII > KMnII which indicates that CoII macrocyclic complex has formed a strong intercalated intermediate. The Stern-Volmer quenching constant (KSV) and voltammetric binding constant were found in the order KSV(CoII) > KSV(NiII) > KSV(MnII) and K+(CoII) > K+(NiII) > K+(MnII) which shows that CoII macrocyclic complex exhibits the high interaction affinity towards ct-DNA by the intercalation binding. Biological studies of the macrocyclic complexes compared with the standard drug like Gentamycin, have shown antibacterial activities against E. coli, P. aeruginosa, B. cereus, S. aureus and antifungal activity against C. albicans.

  8. Microwave synthesis, spectral, thermal and antimicrobial studies of some Ni(II and Cu(II Schiff base complexes

    Directory of Open Access Journals (Sweden)

    A P Mishra

    2012-05-01

    Full Text Available Bidentate and tridentate (NO, (ONO Schiff bases have been synthesized by condensing methyl isobutyl ketone with 2-amino-4-chlorophenol and 2-hydroxy acetophenone with isonicotinic acid hydrazide. The 1:1 or 1:2 metal complexes have been prepared by interacting these Schiff bases with metal ions viz. Ni(II, Cu(II. These compounds have been synthesized by conventional as well as microwave methods and characterized by elemental analysis, FT-IR, UV-Vis, ESR, molar conductance, thermal analysis and X-ray diffraction. The complexes are colored and stable in air at room temperature. The thermal behavior of metal complexes shows that the hydrated complexes loses water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. Crystal data of [Ni(HINH(H2O]Cl.3H2O complex a = b =13.9338Ǻ, c = 34.7975Ǻ, V = 6755.96Ǻ3, Z = 12, Dobs = 1.2421g/cm3, Dcal 1.2847g/cm3, reflect that this complex has crystallized in orthorhombic system. The solid state electrical conductivity of the metal complexes has also been measured. Solid state electrical conductivity studies reflect semiconducting nature of the complexes. The Schiff bases and metal complexes show good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.

  9. Design and Fabrication of High Performance LWIR Photodetectors Based on Type II Superlattices

    Science.gov (United States)

    2017-08-11

    Program Manager Technical Advisor, Space Based Advanced Sensing and Protection JOHN BEAUCHEMIN Chief Engineer, Spacecraft Technology Division Space...34Focal plane arrays in type II-superlattices," USA Patent No. 6864552 (2005). H. Mohseni, A. Tahraoui, J. Wojkowski, M. Razeghi, G. J. Brown , W. C...has reached a level comparable to state of the art MCT detectors (Figure 2-b). 7 8 9 B. M. Nguyen, M. Razeghi, V. Nathan, and Gail J. Brown , "Type-II

  10. Biological Properties Of Benzopyran-Based Platinum (Ii Complexes

    Directory of Open Access Journals (Sweden)

    Malinowska Katarzyna

    2014-04-01

    Full Text Available The aim of the study was to analyze the physicochemical synthesized complex 3 [(1,3- thiazol -2- ylimino methyl]-4H- chromene -4 -one with tetrachloroplatinate(II dipotassium and determination peroxidase activity and glutathione (GPX in red blood cells of cancer patients and healthy subjects. Materials and methods. Tests were carried out with the approval of the Bioethics Committee No. RNN/260/08/KB. Blood was collected into tubes with anticoagulant (heparin lithium. Determination of glutathione peroxidase activity was performed by methods of Little and O’Brien in 20 person groups hospitalized at the Department of General and Colorectal Surgery Veterans General Hospital in Łódź. Results. The study was an increase of activity in the control without the compound and after the introduction of the complex relative to the treatment groups. In healthy subjects, without the use of glutathione peroxidase complex averaged 73.25 ± 23.88 U / g Hb after application of the compound corresponds to the reference group 81.01 ± 25.94 U / g Hb. In contrast, in patients without the use of the complex activity amounted to 42.85 ± 27.49 U / g Hb. In the study group, which uses synthesized complex GPX activity corresponds to 67.72 ± 13.44 U / g Hb. Conclusions. The obtained results underline that the introduction of significant blood antioxidant complex research has a significant impact on the results of the determinations. Statistically significant (p < 0.05 difference occurred in both test and no relation to the administration of the complex in relation to the control of 1. 2.

  11. Designing a heterotrinuclear Cu(II)-Ni(II)-Cu(II) complex from a mononuclear Cu(II) Schiff base precursor with dicyanamide as a coligand: synthesis, crystal structure, thermal and photoluminescence properties.

    Science.gov (United States)

    Hopa, Cigdem; Cokay, Ismail

    2016-08-01

    Schiff bases are considered `versatile ligands' in coordination chemistry. The design of polynuclear complexes has become of interest due to their facile preparations and varied synthetic, structural and magnetic properties. The reaction of the `ligand complex' [CuL] {H2L is 2,2'-[propane-1,3-diylbis(nitrilomethanylylidene)]diphenol} with Ni(OAc)2·4H2O (OAc is acetate) in the presence of dicyanamide (dca) leads to the formation of bis(dicyanamido-1κN(1))bis(dimethyl sulfoxide)-2κO,3κO-bis{μ-2,2'-[propane-1,3-diylbis(nitrilomethanylylidene)]diphenolato}-1:2κ(6)O,O':O,N,N',O';1:3κ(6)O,O':O,N,N',O'-dicopper(II)nickel(II), [Cu2Ni(C17H16N2O2)2(C2N3)2(C2H6OS)2]. The complex shows strong absorption bands in the frequency region 2155-2269 cm(-1), which clearly proves the presence of terminal bonding dca groups. A single-crystal X-ray study revealed that two [CuL] units coordinate to an Ni(II) atom through the phenolate O atoms, with double phenolate bridges between Cu(II) and Ni(II) atoms. Two terminal dca groups complete the distorted octahedral geometry around the central Ni(II) atom. According to differential thermal analysis-thermogravimetric analysis (DTA-TGA), the title complex is stable up to 423 K and thermal decomposition starts with the release of two coordinated dimethyl sulfoxide molecules. Free H2L exhibits photoluminescence properties originating from intraligand (π-π*) transitions and fluorescence quenching is observed on complexation of H2L with Cu(II).

  12. Fluorescent probe based subcellular distribution of Cu(II) ions in living electrotrophs isolated from Cu(II)-reduced biocathodes of microbial fuel cells.

    Science.gov (United States)

    Tao, Ye; Xue, Hua; Huang, Liping; Zhou, Peng; Yang, Wei; Quan, Xie; Yuan, Jinxiu

    2017-02-01

    Based on the four indigenous electrotrophs (Stenotrophomonas maltophilia JY1, Citrobacter sp. JY3, Pseudomonas aeruginosa JY5 and Stenotrophomonas sp. JY6) isolated from well adapted Cu(II)-reduced biocathodes of microbial fuel cells (MFCs), a rhodamine based Cu(II) fluorescent probe was used to imaginably and quantitatively track subcellular Cu(II) ions in these electrotrophs. Cathodic electrons led to more Cu(II) ions (14.3-30.1%) in the intracellular sites at operation time of 2-3h with Cu(II) removal rates of 2.90-3.64mg/Lh whereas the absence of cathodic electrons prolonged the appearance of more Cu(II) ions (16.6-22.5%) to 5h with Cu(II) removal rates of 1.96-2.28mg/Lh. This study illustrates that cathodic electrons directed more Cu(II) ions for quicker entrance into the electrotrophic cytoplasm, and gives an alternative approach for developing imaging and functionally tracking Cu(II) ions in the electrotrophs of MFCs.

  13. Synthesis, characterization, thermal study and biological evaluation of Cu(II), Co(II), Ni(II) and Zn(II) complexes of Schiff base ligand containing thiazole moiety

    Science.gov (United States)

    Nagesh, G. Y.; Mahendra Raj, K.; Mruthyunjayaswamy, B. H. M.

    2015-01-01

    The novel Schiff base ligand 2-(4-(dimethylamino)benzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide (L) obtained by the condensation of N-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 4-dimethylaminobenzaldehyde and its newly synthesized Cu(II), Co(II), Ni(II) and Zn(II) complexes have been characterized by microanalysis, magnetic susceptibility, molar conductance, thermal analysis, FT-IR, 1H NMR, ESI mass, UV-Visible, ESR spectroscopy and powder X-ray diffraction data. The newly synthesized ligand behaves as a bidentate ON donor. The IR results confirmed the bidentate binding of the ligand involving oxygen atom of amide carbonyl and azomethine nitrogen. 1H NMR spectral data of the ligand (L) and its Zn(II) complex agreed well with the proposed structures. In order to evaluate the effect of antimicrobial activity of metal ions upon chelation, the newly synthesized ligand and its metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activities were studied using plasmid DNA pBR322 as a target molecule by agarose gel electrophoresis method. The brine shrimp bioassay was also carried out to study the in vitro cytotoxicity properties of all the compounds against Artemia salina. Furthermore, the antioxidant activity of the ligand (L) and its metal complexes were determined in vitro by reduction of 1,1-diphenyl-2-picryl hydrazyl (DPPH), the ligand exhibited potent in vitro - antioxidant activity than its metal complexes.

  14. Structural and antimicrobial studies of coordination compounds of VO(II, Co(II, Ni(II and Cu(II with some Schiff bases involving 2-amino-4-chlorophenol

    Directory of Open Access Journals (Sweden)

    A. P. MISHRA

    2009-05-01

    Full Text Available Complexes of tailor-made ligands with life essential metal ions may be an emerging area to answer the problem of multi-drug resistance (MDR. The coordination complexes of VO(II, Co(II, Ni(II and Cu(II with the Schiff bases derived from 2-hydroxyacetophenone/2-chlorobenzaldehyde with 2-ami¬no-4-chlorophenol were synthesized and characterized by elemental analysis, molar conductance, electronic spectra, FT-IR, ESR, FAB mass, thermal and magnetic susceptibility measurements. The FAB mass and thermal data show degradation of the complexes. The ligand A (2-hydroxyacetophenone-2amino-4-chlorophenol behaved as tridentate and ligand B (2-chlorobenzylidene-2-amino-4-chlorophenol as bidentate, coordinating through O and N donors. The complexes [VO(A(H2O]×xH2O, [M(A(H2On]×xH2O for Co and Ni, [Cu(A(H2O] and [VO(B2]×xH2O, [M(B2(H2On] for Co and Cu and [Ni(B2] exhibited coordination numbers 4, 5 or 6. X-ray powder diffraction data (a = 11.00417 Å, b = 11.706081 Å and c = 54.46780 Å showed that [Cu(CACP2(H2O2], complex 8, crystallized in the orthorhombic system. The in vitro biological screening effects of the investigated compounds were tested against the bacteria Escherichia coli, Staphylococcus aureus and Streptococcus fecalis and the fungi Aspergillus niger, Trichoderma polysporum and Candida albicans by the serial dilution method. A comparative study of the MIC values of the Schiff base and their [M(B2(H2O2] complexes (Co(II, complex 6 and Cu(II, complex 8, indicated that the metal complexes exhibited a higher or lower antimicrobial activity than 2-chlorobenzylidene-2-amino-4-chlorophenol as the free ligand (B.

  15. Screening for cerebrovascular disease in microcephalic osteodysplastic primordial dwarfism type II (MOPD II): an evidence-based proposal.

    Science.gov (United States)

    Perry, Luke D; Robertson, Fergus; Ganesan, Vijeya

    2013-04-01

    Microcephalic osteodysplastic primordial dwarfism type II (OMIM 210720) is a rare autosomal recessive condition frequently associated with early-onset cerebrovascular disease. Presymptomatic detection and intervention could prevent the adverse consequences associated with this. We reviewed published cases of microcephalic osteodysplastic primordial dwarfism type II to ascertain prevalence and characteristics of cerebrovascular disease and use these data to propose an evidence-based approach to cerebrovascular screening. Of 147 cases identified, 47 had cerebrovascular disease (32%), including occlusive arteriopathy (including moyamoya) and cerebral aneurysmal disease. Occlusive disease occurred in younger individuals, and progression can be both rapid and clinically silent. A reasonable screening approach would be magnetic resonance imaging and angiography of the cervical and intracranial circulation at diagnosis, repeated at yearly intervals until 10 years, and every 2 years thereafter, unless clinical concerns occur earlier. At present it would appear that this needs to be life-long. Families and professionals should be alerted to the potential significance of neurologic symptoms and measures should be taken to maintain good vascular health in affected individuals. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Washback of Task-based Communicative Language Test (II)

    Institute of Scientific and Technical Information of China (English)

    曹敏

    2014-01-01

    The essay aims at revealing the washback effect of task-based communicative language test (TBCLT) in a vocational college, with the further purpose to work out some ways to promote positive washback effect and reform the current tests hence to improve vocational learning.

  17. Spinoza II: Conceptual Case-Based Natural Language Analysis.

    Science.gov (United States)

    Schank, Roger C.; And Others

    This paper presents the theoretical changes that have developed in Conceptual Dependency Theory and their ramifications in computer analysis of natural language. The major items of concern are: the elimination of reliance on "grammar rules" for parsing with the emphasis given to conceptual rule based parsing; the development of a conceptual case…

  18. Polymers Based on Renewable Raw Materials – Part II

    Directory of Open Access Journals (Sweden)

    Jovanović, S.

    2013-09-01

    Full Text Available A short review of biopolymers based on starch (starch derivatives, thermoplastic starch, lignin and hemicelluloses, chitin (chitosan and products obtained by degradation of starch and other polysaccharides and sugars (poly(lactic acid, poly(hydroxyalkanoates, as well as some of their basic properties and application area, are given in this part. The problem of environmental and economic feasibility of biopolymers based on renewable raw materials and their competitiveness with polymers based on fossil raw materials is discussed. Also pointed out are the problems that appear due to the increasing use of agricultural land for the production of raw materials for the chemical industry and energy, instead for the production of food for humans and animals. The optimistic assessments of experts considering the development perspectives of biopolymers based on renewable raw materials in the next ten years have also been pointed out.At the end of the paper, the success of a team of researchers gathered around the experts from the company Bayer is indicated. They were the first in the world to develop a catalyst by which they managed to effectively activate CO - and incorporate it into polyols, used for the synthesis of polyurethanes in semi-industrial scale. By applying this process, for the first time a pollutant will be used as a basic raw material for the synthesis of organic compounds, which will have significant consequences on the development of the chemical industry, and therefore the production of polymers.

  19. Multiporphyrin coordination arrays based on complexation of magnesium(II) porphyrins with porphyrinylphosphine oxides.

    Science.gov (United States)

    Atefi, Farzad; McMurtrie, John C; Arnold, Dennis P

    2007-06-07

    Di- and triporphyrin arrays consisting of 5,15-diphenylporphyrinatomagnesium(II) (MgDPP) coordinated to free-base and Ni(II) porphyrinyl mono- and bis-phosphine oxides, as well as the self-coordinating diphenyl[10,20-diphenylporphyrinatomagnesium(II)-5-yl]phosphine oxide [MgDPP(Ph(2)PO)], were synthesised in excellent yields and characterised by various spectroscopic techniques. Phosphine oxides stabilise Mg(II) coordination to porphyrins and the resulting complexes have convenient solubilities, while the Ni(II) complexes exhibit interesting intramolecular fluorescence quenching behaviour. The binding constant of MgDPP to triphenylphosphine oxide (5.3 +/- 0.1 x 10(5) M(-1)) and the very high self-association constant of [MgDPP(Ph(2)PO)] (5.5 +/- 0.5 x 10(8) M(-1)) demonstrate the strong affinity of phosphine oxides towards Mg(II) porphyrins. These complexes are the first strongly bound synthetic Mg(II) multiporphyrin complexes and could potentially mimic the "special pair" in the photosynthetic reaction centre.

  20. Synthesis, Characterization, and Magnetic and Thermal Studies on Some Metal(II Thiophenyl Schiff Base Complexes

    Directory of Open Access Journals (Sweden)

    Aderoju Amoke Osowole

    2011-01-01

    Full Text Available 4-(Thiophen-3-yl-aniline undergoes condensation with o-vanillin to form an ONS donor Schiff base, 2-methoxy-6-[(4-thiophene-3-yl-phenylimino-methyl]-phenol, which forms complexes of the type [ML2]xH2O (where M = Mn, Co, Ni, Cu, Zn, Pd. These complexes are characterized by elemental analysis, 1H nmr, electronic, mass, and IR spectroscopies and conductance measurements. The electronic, IR and CHN data are supportive of a 4-coordinate tetrahedral geometry for Mn(II, Co(II, Ni(II, and Zn(II complexes and square-planar geometry for Cu(II and Pd(II complexes, with the chromophores N2O2. The magnetic data reveals that the complexes are magnetically dilute and mononuclear with exception of the Cu(II complex, which exhibits some anti-ferromagnetisms. The complexes are air-stable solids, and none is an electrolyte in nitro methane.

  1. Zn(II), Ni(II), Cu(II) and Pb(II) complexes of tridentate asymmetrical Schiff base ligands: Synthesis, characterization, properties and biological activity

    Science.gov (United States)

    Şahin, Mustafa; Koçak, Nuriye; Erdenay, Damla; Arslan, Uğur

    2013-02-01

    New asymmetrical tridentate Schiff base ligands were synthesized using 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde, 9-anthracenecarboxaldehyde. Schiff base ligands and their metal complexes were synthesised and characterized by using FT-IR, 1H NMR, 13C NMR, UV-Vis, XRD, ESR, elemental analysis and fluorescence studies. The antimicrobial activity of the ligands and their metal complexes were studied against Staphylococcus aureus ATCC 29213, S. aureus ATCC 25923, Streptococcus mutans RSHM 676, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853. The determination of the antibacterial activity was done using the broth microdilution methods. In general, it has been determined that the studied compounds have MIC values similar to Gram-positive and Gram-negative bacteria. It has been found that Ni, Pb, Zn derivatives of HL1A and ZnL2A has lower MIC values than ampicillin for P. aeruginosa ATCC 27853 strain.

  2. Antibacterial activity on electrospun poly(lactide-co-glycolide) based membranes via Magainin II grafting

    Energy Technology Data Exchange (ETDEWEB)

    Yüksel, Emre; Karakeçili, Ayşe, E-mail: akarakecili@eng.ankara.edu.tr

    2014-12-01

    An antimicrobial peptide (AMP), Magainin II (Mag II) was covalently immobilized on poly(lactide-co-glycolide) (PLGA) and PLGA/gelatin electrospun fibrous membranes. The surface immobilization was characterized by X-ray Photoelectron Spectroscopy (XPS). Scanning Electron Microscopy (SEM) and Atomic Force Microscopy studies showed that the surface morphology of the fibers at micron scale was not affected by the immobilization process. The antibacterial activity of the bound Mag II was tested against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Bacterial adhesion tests, SEM and confocal analyses revealed that the attachment and survival of bacteria were inhibited on Mag II functionalized membranes. AMP immobilization strategy was introduced as a new perspective for the modulation of antibacterial properties on PLGA based materials prepared by electrospinning. - Highlights: • PLGA and PLGA/gelatin fibrous membranes were prepared by electrospinning. • Antimicrobial peptide Mag II was successfully immobilized on PLGA based membranes. • The antibacterial activity was tested against E. coli and S. aureus. • Bacterial adhesion was inhibited on Mag II functionalized membranes.

  3. Design, spectral characterization and biological studies of transition metal(II) complexes with triazole Schiff bases

    Science.gov (United States)

    Hanif, Muhammad; Chohan, Zahid H.

    2013-03-01

    A new series of three biologically active triazole derived Schiff base ligands L1-L3 have been synthesized in equimolar reaction of 3-amino-1H-1,2,4-triazole with pyrrol-2-carboxaldehyde, 4-bromo-thiophene-2-carboxaldehyde, and 5-iodo-2-hydroxy benzaldehyde. The prepared Schiff bases were used for further complex formation reaction with different metal elements like Co(II), Ni(II), Cu(II) and Zn(II) as chlorides by using a molar ratio of ligand:metal as 2:1. The structure and bonding nature of all the compounds were identified by their physical, spectral and analytical data. All the metal(II) complexes possessed an octahedral geometry except the Cu(II) complexes which showed a distorted octahedral geometry. All the synthesized compounds, were studied for their in vitro antibacterial, and antifungal activities, against four Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains and against six fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata) by using agar-well diffusion method. It has been shown that all the synthesized compounds showed moderate to significant antibacterial activity against one or more bacterial strains. In vitro Brine Shrimp bioassay was also carried out to investigate the cytotoxic properties of these compounds. The data also revealed that the metal complexes showed better activity than the ligands due to chelation/coordination.

  4. Design, spectral characterization and biological studies of transition metal(II) complexes with triazole Schiff bases.

    Science.gov (United States)

    Hanif, Muhammad; Chohan, Zahid H

    2013-03-01

    A new series of three biologically active triazole derived Schiff base ligands L(1)-L(3) have been synthesized in equimolar reaction of 3-amino-1H-1,2,4-triazole with pyrrol-2-carboxaldehyde, 4-bromo-thiophene-2-carboxaldehyde, and 5-iodo-2-hydroxy benzaldehyde. The prepared Schiff bases were used for further complex formation reaction with different metal elements like Co(II), Ni(II), Cu(II) and Zn(II) as chlorides by using a molar ratio of ligand:metal as 2:1. The structure and bonding nature of all the compounds were identified by their physical, spectral and analytical data. All the metal(II) complexes possessed an octahedral geometry except the Cu(II) complexes which showed a distorted octahedral geometry. All the synthesized compounds, were studied for their in vitro antibacterial, and antifungal activities, against four Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains and against six fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata) by using agar-well diffusion method. It has been shown that all the synthesized compounds showed moderate to significant antibacterial activity against one or more bacterial strains. In vitro Brine Shrimp bioassay was also carried out to investigate the cytotoxic properties of these compounds. The data also revealed that the metal complexes showed better activity than the ligands due to chelation/coordination.

  5. Curriculum for Evidence Based Medicine for MBBS II phase Graduates

    Directory of Open Access Journals (Sweden)

    Saxena R

    2014-12-01

    Full Text Available Evidence based medicine is the training of health care professionals to access, assess and apply the best scientific evidence to clinical practice. EBM is the conscientious, explicit and judicious use of current best evidence along with clinical expertise and patient values in making decisions about the case of individual patients. The current undergraduate curriculum of health profession is based on past knowledge accumulated for years. The scientific relevance of the mostly outdated information has never been questioned. The students passively absorb this available knowledge and apply it in their future professional life. There is no active learning on their part, by way of positive enquiry and critical analysis of the curriculum imposed on them. This has an undesirable impact on their competency as health professionals and the quality of the health care imparted by them. Hence there is need for emphasis on the teaching of EBM skills in undergraduate, postgraduate, and continuing medical education programs. Early introduction of EBM in the undergraduate medical curriculum, in the form of a short course, using various modes of instruction, enhances the competence of critical thinking and also influences change in attitude towards EBM positively in medical students. The EBM course is planned to introduce in the curriculum of medical undergraduates at the beginning of second phase when they enter clinical posting. Total number of student would be 100 per batch and the course duration will be of 1 year. Educational methods program incorporates multiple teaching methods like lectures, discussion sessions, demonstration, case based learning, timely feedback, real life exposure, role modeling and peer evaluation.

  6. Synthesis and characterization of binary and ternary complexes of Co(II), Ni(II), Cu(II) and Zn(II) ions based on 4-aminotoluene-3-sulfonic acid

    Science.gov (United States)

    Faheim, Abeer A.; Abdou, Safaa N.; Abd El-Wahab, Zeinab H.

    2013-03-01

    Salicylidene (4-aminotoluene-3-sulfonic acid) Schiff base ligand H2L, and its binary and ternary Co(II), Ni(II), Cu(II) and Zn(II) complexes using 8-hydroxyquinoline (8-HOqu) and 2-aminopyridine (2-Ampy) as secondary ligands have been synthesised and characterized via elemental analysis, spectral data (IR, 1H NMR, mass and solid reflectance), molar conductance, magnetic moment, TG-DSC measurements and XRPD analysis. Correlation of all spectroscopic data suggest that H2L ligand acts as monoanionic terdentate ligand with ONO sites coordinating to the metal ions via deprotonated phenolic-O, azomethine-N and sulfonate-O while 2-Ampy behaves as a neutral monodentate ligand via amino group-N and 8-HOqu behaves as a monoanionic bidentate ligand through the ring-N and deprotonated phenolic-O. The thermal behavior of these complexes shows that the coordinated water molecules were eliminated from the complexes at relatively higher temperatures than the hydrated water and there are two routes in removal of coordinated water molecules. All complexes have mononuclear structure and the tetrahedral, square planar or an octahedral geometry have been proposed. The ligand and its complexes have been screened for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhimurium, Candida albicans and Aspergillus fumigatus. Among the synthesised compounds, the binary and ternary Ni(II) complexes, (2, 8 and 10) and ternary Zn(II) complex, (12) were found to be very effective against Candida albicans and Bacillus subtilis than all other complexes with MICs of 2 and 8 μg/mL, respectively.

  7. Potentiometric Polymeric Film Sensors Based on 5,10,15-tris(4-aminophenyl Porphyrinates of Co(II and Cu(II for Analysis of Biological Liquids

    Directory of Open Access Journals (Sweden)

    Larisa Lvova

    2011-01-01

    Full Text Available Novel carbonate-selective potentiometric sensors based on 5,10,15-tris(4-aminophenyl-20-phenyl porphyrinates of Cu(II and Co(II have been developed. Ionophore functioning mechanism and possible source of carbonate sensitivity have been evolved. Potentiometric properties of Co(II- and Cu(IITATPP-based sensors were compared with common carbonate-ISEs containing trifluoroacetophenone derivatives. The analytical utility of newly developed sensors has been demonstrated by measuring the bicarbonate content in human blood plasma.

  8. Synthesis and Crystal Structures of Ni(II)/(III) and Zn(II) Complexes with Schiff Base Ligands

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Bon Kweon [Catholic Univ., of Daegu, Daegu (Korea, Republic of)

    2013-12-15

    Coordination polymers are of great interest due to their intriguing structural motifs and potential applications in optical, electronic, magnetic, and porous materials. The most commonly used strategy for designing such materials relies on the utilization of multidentate N- or Odonor ligands which have the capacity to bridge between metal centers to form polymeric structures. The Schiff bases with N,O,S donor atoms are an useful source as they are readily available and easily form stable complexes with most transition metal ions. Schiff bases are also important intermediates in synthesis of some bioactive compounds and are potent anti-bacterial, anti-fungal, anticancer and antiviral compounds. In this work, the Schiff bases, Hapb and Hbpb, derived from 2-acetylpyridene or 2-benzoylpyridine and benzhydrazide were taken as trifunctional (N,N,O) monobasic ligand (Scheme 1). This ligand is of important because the π-delocalization of charge and the configurational flexibility of their molecular chain can give rise to a great variety of coordination modes. Although many metal.Schiff base complexes have been reported, the 1D, 2D, and 3D networks of coordination polymers linked through the bridging of ligands such as dicyanamide, N(CN){sub 2}{sup -} as coligand have been little published. In the process of working to extend the dimensionality of the metal-Schiff base complexes using benzilic acid as a bridging ligand, we obtained three simple metal (II)/(III) complexes of acetylpyridine/2-benzoyl pyridine based benzhydrazide ligand. Therefore, we report here the synthesis and crystal structures of the complexes.

  9. Improved NSGA-II Based on a Novel Ranking Scheme

    CERN Document Server

    D'Souza, Rio G L; Kandasamy, A

    2010-01-01

    Non-dominated Sorting Genetic Algorithm (NSGA) has established itself as a benchmark algorithm for Multiobjective Optimization. The determination of pareto-optimal solutions is the key to its success. However the basic algorithm suffers from a high order of complexity, which renders it less useful for practical applications. Among the variants of NSGA, several attempts have been made to reduce the complexity. Though successful in reducing the runtime complexity, there is scope for further improvements, especially considering that the populations involved are frequently of large size. We propose a variant which reduces the run-time complexity using the simple principle of space-time trade-off. The improved algorithm is applied to the problem of classifying types of leukemia based on microarray data. Results of comparative tests are presented showing that the improved algorithm performs well on large populations.

  10. Do orthodontists recommend Class II treatment according to evidence-based knowledge?

    Directory of Open Access Journals (Sweden)

    Soraia Azevedo Almeida

    Full Text Available AbstractIntroductionThe adequate indications for the timing of treatment for Class II malocclusion are mandatory for the ethical and efficient practice of orthodontics, but clinicians are reluctant to accept new information that contradicts their preferred method of treatment.ObjectiveThe aim of this investigation was to assess the agreement regarding the indications for Class II malocclusion interceptive therapy between a group of international opinion-makers on early treatment and a group of orthodontists and to compare their treatment indications with the current evidence-based knowledge.Material and methodAn electronic survey containing photographs of mild, moderate and severe Class II malocclusions in children was sent to two panels of experts. Panel 1 (n=28 was composed of international orthodontists who had authored world-class publications on early orthodontic treatment, and Panel 2 (n=261 was composed of clinical orthodontists. Based on a 5-point Likert-type scale, the orthodontists selected their therapy option for each of the 9 Class II malocclusion cases.ResultThe Class II malocclusion treatment recommendations of Panel 2 were significantly different from those offered by Panel 1 with a skew of at least 1 scale point toward earlier treatment. The Class II malocclusion treatment recommendations of the members of Panel 1 members were in accordance with contemporary evidence-based knowledge.ConclusionClass II malocclusion overtreatment appears to be the tendency among clinical orthodontists but not among orthodontists who are academically involved with early treatment. There is a gap between the scientific knowledge and the practices of orthodontists.

  11. Differential geometry based solvation model II: Lagrangian formulation.

    Science.gov (United States)

    Chen, Zhan; Baker, Nathan A; Wei, G W

    2011-12-01

    Solvation is an elementary process in nature and is of paramount importance to more sophisticated chemical, biological and biomolecular processes. The understanding of solvation is an essential prerequisite for the quantitative description and analysis of biomolecular systems. This work presents a Lagrangian formulation of our differential geometry based solvation models. The Lagrangian representation of biomolecular surfaces has a few utilities/advantages. First, it provides an essential basis for biomolecular visualization, surface electrostatic potential map and visual perception of biomolecules. Additionally, it is consistent with the conventional setting of implicit solvent theories and thus, many existing theoretical algorithms and computational software packages can be directly employed. Finally, the Lagrangian representation does not need to resort to artificially enlarged van der Waals radii as often required by the Eulerian representation in solvation analysis. The main goal of the present work is to analyze the connection, similarity and difference between the Eulerian and Lagrangian formalisms of the solvation model. Such analysis is important to the understanding of the differential geometry based solvation model. The present model extends the scaled particle theory of nonpolar solvation model with a solvent-solute interaction potential. The nonpolar solvation model is completed with a Poisson-Boltzmann (PB) theory based polar solvation model. The differential geometry theory of surfaces is employed to provide a natural description of solvent-solute interfaces. The optimization of the total free energy functional, which encompasses the polar and nonpolar contributions, leads to coupled potential driven geometric flow and PB equations. Due to the development of singularities and nonsmooth manifolds in the Lagrangian representation, the resulting potential-driven geometric flow equation is embedded into the Eulerian representation for the purpose of

  12. THEORY OF REGENERATION BASED ON MASS ACTION. II.

    Science.gov (United States)

    Loeb, J

    1923-11-20

    1. Quantitative proof is furnished that all the material available for shoot and root formation in an isolated leaf of Bryophyllum calycinum flows to those notches where through the influence of gravity or by a more abundant supply of water growth is accelerated. As soon as the acceleration of growth in these notches commences, the growth of shoots and roots in the other notches which may already have started ceases. 2. It had been shown in a preceding paper that the regeneration of an isolated piece of stem may be and frequently is in the beginning not markedly polar, but that after some time the growth of all the roots except those at the base and of all the shoots except those at the apex is suppressed. This analogy with the behavior of regeneration in a leaf in which the growth in one set of notches is accelerated, suggests that in an isolated stem a more rapid growth is favored at the extreme ends (probably by a block of the sap flow at the extreme ends) and that when this happens the total flow of ascending sap goes to the most apical buds and the total flow of the descending sap goes to the most basal roots. As soon as this occurs, the growth of the other roots and shoots is suppressed.

  13. A label-free colorimetric aptasensor for simple, sensitive and selective detection of Pt (II) based on platinum (II)-oligonucleotide coordination induced gold nanoparticles aggregation.

    Science.gov (United States)

    Fan, Daoqing; Zhai, Qingfeng; Zhou, Weijun; Zhu, Xiaoqing; Wang, Erkang; Dong, Shaojun

    2016-11-15

    Herein, a gold nanoparticles (AuNPs) based label-free colorimetric aptasensor for simple, sensitive and selective detection of Pt (II) was constructed for the first time. Four bases (G-G mismatch) mismatched streptavidin aptamer (MSAA) was used to protect AuNPs from salt-induced aggregation and recognize Pt (II) specifically. Only in the presence of Pt (II), coordination occurs between G-G bases and Pt (II), leading to the activation of streptavidin aptamer. Streptavidin coated magnetic beads (MBs) were used as separation agent to separate Pt (II)-coordinated MSAA. The residual less amount of MSAA could not efficiently protect AuNPs anymore and aggregation of AuNPs will produce a colorimetric product. With the addition of Pt (II), a pale purple-to-blue color variation could be observed by the naked eye. A detection limit of 150nM and a linear range from 0.6μM to 12.5μM for Pt (II) could be achieved without any amplification.

  14. The Chimera II Real-Time Operating System for advanced sensor-based control applications

    Science.gov (United States)

    Stewart, David B.; Schmitz, Donald E.; Khosla, Pradeep K.

    1992-01-01

    Attention is given to the Chimera II Real-Time Operating System, which has been developed for advanced sensor-based control applications. The Chimera II provides a high-performance real-time kernel and a variety of IPC features. The hardware platform required to run Chimera II consists of commercially available hardware, and allows custom hardware to be easily integrated. The design allows it to be used with almost any type of VMEbus-based processors and devices. It allows radially differing hardware to be programmed using a common system, thus providing a first and necessary step towards the standardization of reconfigurable systems that results in a reduction of development time and cost.

  15. Synthesis, Spectroscopic, Anticancer, and Antimicrobial Properties of Some Metal(II Complexes of (Substituted Nitrophenol Schiff Base

    Directory of Open Access Journals (Sweden)

    Aderoju A. Osowole

    2012-01-01

    Full Text Available The Schiff base, 2-[(2,3-dihydro-1H-inden-4-yliminomethyl]-5-nitrophenol coordinates to Mn(II, Cu(II, Zn(II, and Pd(II ions through the phenolic O and imine N atoms. The complexes are characterized by physicochemical and spectroscopic methods. The metal complexes formed as [ML2]xH2O with exception of the Cu(II complex which is anhydrous. Spectroscopic data corroborate the adoption of a four-coordinate, tetrahedral geometry for the Mn(II, and Zn(II complexes, and a four-coordinate, square planar geometry for the Cu(II and Pd(II complexes. None is an electrolyte in DMSO. The in vitro anticancer activities of the metal free ligand, Cu(II, Zn(II, and Pd(II complexes against MCF-7 (human breast adenocarcinoma and HT-29 (colon carcinoma cells reveal that the Pd(II complex has the best cytotoxic activity against MCF-7 cells with an IC50 of 5.94 μM, which is within the same order of activity as cisplatin. Furthermore, the ligand and the Zn(II complex exhibit broad-spectrum activity against two gram-positive bacteria, three gram-negative bacteria, and a fungus with inhibitory zones range of 10.0–20.0 and 10.0–17.0 mm, respectively.

  16. Removal of Co(II), Cu(II) and Pb(II) ions by polymer based 2-hydroxyethyl methacrylate: thermodynamics and desorption studies

    OpenAIRE

    Omid Moradi; Behrooz Mirza; Mehdi Norouzi; Ali Fakhri

    2012-01-01

    Abstract Removal thermodynamics and desorption studies of some heavy metal ions such as Co(II), Cu(II) and Pb(II) by polymeric surfaces such as poly 2-hydroxyethyl methacrylate (PHEMA) and copolymer 2-hydroxyethyl methacrylate with monomer methyl methacrylate P(MMA-HEMA) as adsorbent surfaces from aqueous single solution were investigated with respect to the changes in pH of solution, adsorbent composition, contact time and temperature in the individual aqueous solution. The linear correlatio...

  17. Synthesis, spectroscopic characterization and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff bases derived from 5-bromo-salicylaldehyde

    Science.gov (United States)

    Kursunlu, Ahmed Nuri; Guler, Ersin; Sevgi, Fatih; Ozkalp, Birol

    2013-09-01

    In this study, the new Schiff base ligands derived from condensation of amine and 5-bromo-salicylaldehyde were characterized. All compounds, the Schiff bases and the metal complexes, were characterized by elemental analyzes, FT-IR, 1H NMR, 13C NMR and magnetic susceptibility measurements. The synthesized ligands, along with their metal (II) complexes, were screened for their in vitro antibacterial activity against four Gram-negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteritidis) and four Gram-positive (Streptococcus pyogones, Bacillus cereus, Staphylococcus aureus and Methicillin-resistant S. aureus) bacterial strains by using disc diffusion and broth microdilution techniques.

  18. High-field Faraday rotation in II-VI-based semimagnetic semiconductors

    NARCIS (Netherlands)

    Savchuk, AI; Fediv, [No Value; Nikitin, PI; Perrone, A; Tatzenko, OM; Platonov, VV

    1998-01-01

    The effects of d-d exchange interaction have been studied by measuring high-field Faraday rotation in II-VI-based semimagnetic semiconductors. For Cd1-xMnxTe crystals with x = 0.43 and at room temperature a saturation in magnetic field dependence of the Faraday rotation has been observed. In the cas

  19. A saponification-triggered gelation of ester-based Zn(II) complex through conformational transformations.

    Science.gov (United States)

    Kumar, Ashish; Dubey, Mrigendra; Kumar, Amit; Pandey, Daya Shankar

    2014-09-11

    Novel saponification-triggered gelation in an ester-based bis-salen Zn(II) complex (1) is described. Strategic structural modifications induced by NaOH in 1 tune the dipolar-/π-interactions leading to J-aggregation and the creation of an inorganic gel material (IGM), which has been established by photophysical, DFT and rheological studies.

  20. Implementation of a Proficiency-Based Diploma System in Maine: Phase II--District Level Analysis

    Science.gov (United States)

    Silvernail, David L.; Stump, Erika K.; McCafferty, Anita Stewart; Hawes, Kathryn M.

    2014-01-01

    This report describes the findings from Phase II of a study of Maine's implementation of a proficiency-based diploma system. At the request of the Joint Standing Committee on Education and Cultural Affairs of the Maine Legislature, the Maine Policy Research Institute (MEPRI) has conducted a two-phased study of the implementation of Maine law…

  1. Mn(II) and Cu(II) complexes of a bidentate Schiff's base ligand: Spectral, thermal, molecular modelling and mycological studies

    Science.gov (United States)

    Tyagi, Monika; Chandra, Sulekh; Tyagi, Prateek

    2014-01-01

    Complexes of manganese(II) and copper(II) of general composition M(L)2X2 have been synthesized [L = 2-acetyl thiophene thiosemicarbazone and X = Cl- and NO3-]. The elemental analysis, molar conductance measurements, magnetic susceptibility measurements, mass, IR, UV, NMR and EPR spectral studies of the compounds led to the conclusion that the ligand acts as a bidentate manner. The Schiff's base ligand forms hexacoordinated complexes having octahedral geometry for Mn(II) and tetragonal geometry for Cu(II) complexes. The thermal studies suggested that the complexes are more stable as compared to ligand. In molecular modelling the geometries of Schiff's base and metal complexes were fully optimized with respect to the energy using the 6-31g(d,p) basis set. The mycological studies of the compounds were examined against the plant pathogenic fungi i.e. Rhizoctonia bataticola, Macrophomina phaseolina, Fusarium odum.

  2. Ground-based and spaceborn observations of the type II burst with developed fine structure

    Science.gov (United States)

    Dorovskyy, V.; Melnik, V.; Konovalenko, A.; Brazhenko, A.; Rucker, H.; Stanislavskyy, A.; Panchenko, M.

    2012-09-01

    The combination of two huge ground-based radio telescopes (UTR-2 and URAN-2) operated in decameter wavelengths with three spatially separated spacecrafts (SOHO, STEREO-A and STEREO-B) equipped with white light coronagraphs, UV telescopes and decameter-hectometer band radio telescopes created a unique opportunity to investigate the high energy solar transients, such as CMEs and their manifestations in radio bands - type II bursts. In this paper we made detailed analysis of the powerful and complex event occurred on 7 June 2011 consisted of Halo-CME and type II burst with rich fine structure.

  3. A scintillator based muon and KLong detector for the Belle II experiment

    CERN Document Server

    Aushev, T; Chilikin, K; Chistov, R; Danilov, M; Katrenko, P; Mizuk, R; Pakhlova, G; Pakhlov, P; Rusinov, V; Solovieva, E; Tarkovsky, E; Tikhomirov, I; Uglov, T

    2014-01-01

    A new muon and K_Long detector based on scintillators will be used for the endcap and inner barrel regions in the Belle II experiment, currently under construction. The increased luminosity of the e+e- SuperKEKB collider entails challenging detector requirements. We demonstrate that relatively inexpensive polystyrene scintillator stips with wave length shifting fibers ensure a sufficient light yield at the Silcon PhotoMultiplier (SiPM) photodetector, are robust and provide improved physics performance for the Belle II experiment compared to its predecessor, Belle.

  4. Tripodal phenylamine-based ligands and their CoII complexes.

    Science.gov (United States)

    Jones, Matthew B; MacBeth, Cora E

    2007-10-01

    The syntheses of two phenylamine-based ligand systems, N(o-PhNH(2))(3) and N(o-PhNHC(O)(i)Pr)(3), are reported. These ligands readily coordinate to Co(II) to form monomeric complexes. X-ray diffraction studies establish that the [N(o-PhNC(O)(i)Pr)(3)](3-) ligand stabilizes the Co(II) ion in a trigonal-monopyramidal coordination environment. The axial coordination site in this complex is accessible and, upon cyanide coordination, generates an electrochemically active species.

  5. Spectrophotometric Study of Stability Constants of Cr(III, Ni(II and Cu(II Complexes with a Schiff’s Base in Different Solvents

    Directory of Open Access Journals (Sweden)

    Israel Leka Lere

    2013-12-01

    Full Text Available Complexation of Cr(III, Ni(II and Cu(II with para-dimethylaminoanil of ortho-hydroxyphenylglyoxal Schiff’s base in methanol, ethanol and acetone solvents has been studied spectrophotometrically at room temperature (298K. The stoichiometry and stability of the complexes were determined using mole-ratio method. Stability data shows solvent-wise stability order as methanol > ethanol > acetone.

  6. Removal of Co(II), Cu(II) and Pb(II) ions by polymer based 2-hydroxyethyl methacrylate: thermodynamics and desorption studies.

    Science.gov (United States)

    Moradi, Omid; Mirza, Behrooz; Norouzi, Mehdi; Fakhri, Ali

    2012-12-22

    Removal thermodynamics and desorption studies of some heavy metal ions such as Co(II), Cu(II) and Pb(II) by polymeric surfaces such as poly 2-hydroxyethyl methacrylate (PHEMA) and copolymer 2-hydroxyethyl methacrylate with monomer methyl methacrylate P(MMA-HEMA) as adsorbent surfaces from aqueous single solution were investigated with respect to the changes in pH of solution, adsorbent composition, contact time and temperature in the individual aqueous solution. The linear correlation coefficients of Langmuir and Freundlich isotherms were obtained and the results revealed that the Langmuir isotherm fitted the experiment results better than Freundlich isotherm. Using the Langmuir model equation, the monolayer removal capacity of PHEMA surface was found to be 0.7388, 0.8396 and 3.0367 mg/g for Co(II), Cu(ΙΙ) and Pb(II) ions and removal capacity of P(MMA-HEMA) was found to be 28.8442, 31.1526 and 31.4465 mg/g for Co(II), Cu(ΙΙ) and Pb(II) ions, respectively. Changes in the standard Gibbs free energy (ΔG0), standard enthalpy (ΔH0) and standard entropy (ΔS0) showed that the removals of mentioned ions onto PHEMA and P(MMA-HEMA) are spontaneous and exothermic at 293-323 K. The maximum desorption efficiency was 75.26% for Pb(II) using 0.100 M HNO3, 70.10% for Cu(II) using 0.100 M HCl, 59.20% for 0.100 M HCl 63.67% Co(II).

  7. Removal of Co(II, Cu(II and Pb(II ions by polymer based 2-hydroxyethyl methacrylate: thermodynamics and desorption studies

    Directory of Open Access Journals (Sweden)

    Moradi Omid

    2012-12-01

    Full Text Available Abstract Removal thermodynamics and desorption studies of some heavy metal ions such as Co(II, Cu(II and Pb(II by polymeric surfaces such as poly 2-hydroxyethyl methacrylate (PHEMA and copolymer 2-hydroxyethyl methacrylate with monomer methyl methacrylate P(MMA-HEMA as adsorbent surfaces from aqueous single solution were investigated with respect to the changes in pH of solution, adsorbent composition, contact time and temperature in the individual aqueous solution. The linear correlation coefficients of Langmuir and Freundlich isotherms were obtained and the results revealed that the Langmuir isotherm fitted the experiment results better than Freundlich isotherm. Using the Langmuir model equation, the monolayer removal capacity of PHEMA surface was found to be 0.7388, 0.8396 and 3.0367 mg/g for Co(II, Cu(ΙΙ and Pb(II ions and removal capacity of P(MMA-HEMA was found to be 28.8442, 31.1526 and 31.4465 mg/g for Co(II, Cu(ΙΙ and Pb(II ions, respectively. Changes in the standard Gibbs free energy (ΔG0, standard enthalpy (ΔH0 and standard entropy (ΔS0 showed that the removals of mentioned ions onto PHEMA and P(MMA-HEMA are spontaneous and exothermic at 293–323 K. The maximum desorption efficiency was 75.26% for Pb(II using 0.100 M HNO3, 70.10% for Cu(II using 0.100 M HCl, 59.20% for 0.100 M HCl 63.67% Co(II.

  8. Removal of Co(II, Cu(II and Pb(II Ions by Polymer Based 2-Hydroxyethyl Methacrylate:Thermodynamics and Desorption Studies

    Directory of Open Access Journals (Sweden)

    Omid Moradi

    2012-12-01

    Full Text Available Removal thermodynamics and desorption studies of some heavy metal ions such as Co(II, Cu(II and Pb(II by polymeric surfaces such as poly 2-hydroxyethyl methacrylate (PHEMA and copolymer 2-hydroxyethyl methacrylate with monomer methyl methacrylate P(MMA-HEMA as adsorbent surfaces from aqueous single solution were investigated with respect to the changes in pH of solution, adsorbent composition, contact time and temperature in the individual aqueous solution. The linear correlation coefficients of Langmuir and Freundlich isotherms wereobtained and the results revealed that the Langmuir isotherm fitted the experiment results better than Freundlichisotherm. Using the Langmuir model equation, the monolayer removal capacity of PHEMA surface was found to be0.7388, 0.8396 and 3.0367 mg/g for Co(II, Cu(ΙΙ and Pb(II ions and removal capacity of P(MMA-HEMA was found to be 28.8442, 31.1526 and 31.4465 mg/g for Co(II, Cu(ΙΙ and Pb(II ions, respectively. Changes in the standard Gibbs free energy (ΔG0, standard enthalpy (ΔH0 and standard entropy (ΔS0 showed that the removals of mentioned ions onto PHEMA and P(MMA-HEMA are spontaneous and exothermic at 293–323 K. The maximum desorption efficiency was 75.26% for Pb(II using 0.100 M HNO3, 70.10% for Cu(II using 0.100 M HCl, 59.20% for 0.100 M HCl 63.67% Co(II.

  9. Approximate Bayes Estimators of the Logistic Distribution Parameters Based on Progressive Type-II Censoring Scheme

    Directory of Open Access Journals (Sweden)

    Mohamed Mahmoud Mohamed

    2016-09-01

    Full Text Available In this paper we develop approximate Bayes estimators of the parameters,reliability, and hazard rate functions of the Logistic distribution by using Lindley’sapproximation, based on progressively type-II censoring samples. Noninformativeprior distributions are used for the parameters. Quadratic, linexand general Entropy loss functions are used. The statistical performances of theBayes estimates relative to quadratic, linex and general entropy loss functionsare compared to those of the maximum likelihood based on simulation study.

  10. Ligand-based reduction of CO2 and release of CO on iron(II).

    Science.gov (United States)

    Thammavongsy, Zachary; Seda, Takele; Zakharov, Lev N; Kaminsky, Werner; Gilbertson, John D

    2012-09-01

    A synthetic cycle for the CO(2)-to-CO conversion (with subsequent release of CO) based on iron(II), a redox-active pydridinediimine ligand (PDI), and an O-atom acceptor is reported. This conversion is a passive-type ligand-based reduction, where the electrons for the CO(2) conversion are supplied by the reduced PDI ligand and the ferrous state of the iron is conserved.

  11. Antibacterial activity of Pd(II) complexes with salicylaldehyde-amino acids Schiff bases ligands.

    Science.gov (United States)

    Rîmbu, Cristina; Danac, Ramona; Pui, Aurel

    2014-01-01

    Palladium(II) complexes with Schiff bases ligands derived from salicylaldehyde and amino acids (Ala, Gly, Met, Ser, Val) have been synthesized and characterized by Fourier transform (FT)-IR, UV-Vis and (1)H-NMR spectroscopy. The electrospray mass spectrometry (ES-MS) spectrometry confirms the formation of palladium(II) complexes in 1/2 (M/L) molar ratio. All the Pd(II) complexes 1, [Pd(SalAla)2]Cl2; 2, [Pd(SalGly)2]Cl2; 3, [Pd(SalMet)2]Cl2; 4, [Pd(SalSer)2]Cl2; 5, [Pd(SalVal)2]Cl2; have shown antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli.

  12. A one-dimensional chain structure based on unusual tetranuclear manganese(II) clusters.

    Science.gov (United States)

    Che, Guang Bo; Wang, Jian; Liu, Chun Bo; Li, Xiu Ying; Liu, Bo

    2008-11-01

    The title coordination polymer, poly[bis(mu(4)-biphenyl-2,2'-dicarboxylato)(dipyrido[3,2-a:2',3'-c]phenazine)manganese(II)], [Mn(2)(C(14)H(8)O(4))(2)(C(18)H(10)N(4))](n), was obtained through the reaction of MnCl(2).4H(2)O, biphenyl-2,2'-dicarboxylic acid (H(2)dpdc) and dipyrido[3,2-a:2',3'-c]phenazine (L) under hydrothermal conditions. The asymmetric unit contains two crystallographically unique Mn(II) ions, one unique L ligand and two unique dpdc ligands. One Mn ion is six-coordinated by four O atoms from three different dpdc ligands and two N atoms from one L ligand, adopting a distorted octahedral coordination geometry. The distortions from ideal octahedral geometry are largely due to the presence of chelating ligands and the resulting acute N-Mn-N and O-Mn-O angles. The second Mn ion is coordinated in a distorted trigonal bipyramidal fashion by five O atoms from four distinct dpdc ligands. Four Mn(II) ions are bridged by the carboxylate groups of the dpdc ligands to form an unusual tetranuclear Mn(II) cluster. Clusters are further connected by the aromatic backbone of the dicarboxylate ligands, forming a one-dimensional chain structure along the b axis. The title compound is the first example of a chain structure based on a tetranuclear Mn(II) cluster.

  13. Synthesis, spectral characterization, structural investigation and antimicrobial studies of mononuclear Cu(II), Ni(II), Co(II), Zn(II) and Cd(II) complexes of a new potentially hexadentate N2O4 Schiff base ligand derived from salicylaldehyde

    Science.gov (United States)

    Keypour, Hassan; Shayesteh, Maryam; Rezaeivala, Majid; Chalabian, Firoozeh; Elerman, Yalcin; Buyukgungor, Orhan

    2013-01-01

    A new potentially hexadentate N2O4 Schiff base ligand, H2L derived from condensation reaction of an aromatic diamine and salicylaldehyde, and its metal complexes were characterized by elemental analyses, IR, UV-Vis, EI-MS, 1H and 13C NMR spectra, as well as conductance measurements. It has been originated that the Schiff base ligand with Cu(II), Ni(II), Co(II), Cd(II) and Zn(II) ions form mononuclear complexes on 1:1 (metal:ligand) stoichiometry. The conductivity data confirm the non-electrolytic nature of the complexes. Also the crystal structures of the complexes [ZnL] and [CoL] have also been determined by using X-ray crystallographic technique. The Zn(II) and Co(II) complexes show a tetrahedral configuration. Electronic absorption spectra of the Cu(II) and Ni(II) complexes suggest a square-planar geometry around the central metal ion. The synthesized compounds have antibacterial activity against the three Gram-positive bacteria: Bacillus cereus, Enterococcus faecalis and Listeria monocytogenes and also against the three Gram-negative bacteria: Salmonella paraB, Citrobacter freundii and Enterobacter aerogenes. The results showed that in some cases the antibacterial activity of complexes were more than nalidixic acid and amoxicillin as standards.

  14. Schiff base ligand derived from (±trans-1,2-cyclohexanediamine and its Cu(II, Co(II, Zn(II and Mn(II complexes: Synthesis, characterization, styrene oxidation and hydrolysis study of the imine bond in Cu(II Schiff base complex

    Directory of Open Access Journals (Sweden)

    Sarkheil Marzieh

    2016-01-01

    Full Text Available A Schiff base ligand (H2L derived from 2´-hydroxypropiophenone and (±trans-1,2-cyclohexanediamine was synthesized. The reactions of MCl2.xH2O (M =Cu(II, Co(II, Zn(II and Mn(IIwith the di-Schiff base ligand (H2L were studied. This ligand when stirred with 1 equivalent of CuCl2.2H2O in the solution of ethanol and chloroform undergoes partial hydrolysis of the imino bond and the resultant tridentate ligand (HL′immediately forms complex[CuL´Cl]∙3/2CHCl3(1with N2O coordination sphere. Under the same condition, the reaction of H2L with MCl2.xH2O (M = Co(II (3, Zn(II (4 and Mn(II (5 gave complexes[ML]•1/2CHCl3∙3/2H2O (3-5with N2O2 coordination sphere and no hydrolytic cleavage was occurred. Also, the reaction of H2L with CuCl2.2H2O in THF gave the complex CuL (2with N2O2 coordination sphere. The ligand and complexes were characterized by FTIR, UV-Vis, 1H NMRand elemental analysis. The homogeneous catalytic activity of the complexes1, 3 and 5wasevaluated for the oxidation of styrene using tert-butyl hydroperoxide (TBHP as oxidant. Finally, the copper(II complex(1encapsulated in the nanopores of zeolite-Y by flexible ligand method (CuL´-Yand its encapsulation was ensured by different studies. The catalytic performance of heterogeneous catalyst in the styrene oxidation with TBHP was investigated. The catalytic tests showed that the homogenous and heterogeneous catalysts were active in the oxidation of styrene.

  15. Synthesis, characterization and biological activity of ferrocene-based Schiff base ligands and their metal (II) complexes

    Science.gov (United States)

    Liu, Yu-Ting; Lian, Gui-Dan; Yin, Da-Wei; Su, Bao-Jun

    Metal (II) complexes derived from S-benzyl-N-(1-ferrocenyl-3-(4-methylbenzene)acrylketone) dithiocarbazate; HL1, S-benzyl-N-(1-ferrocenyl-3-(4-chlorobenzene)acrylketone)dithiocarbazate; HL2, all the compounds were characterized using various spectroscopic techniques. The molar conductance data revealed that the chelates were non-electrolytes. IR spectra showed that the Schiff bases were coordinated to the metal ions in a bidentate manner with N, S donor sites. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal properties. The result of these studies have revealed that zinc (II) complexes 6 and 13 of both the ligands and copper (II) complexes 9 of the HL2 were observed to be the most active against all bacterial strains, antifungal activity was overall enhanced after complexation of the ligands.

  16. Interval Type-II Fuzzy Rule-Based STATCOM for Voltage Regulation in the Power System

    Directory of Open Access Journals (Sweden)

    Ying-Yi Hong

    2015-08-01

    Full Text Available The static synchronous compensator (STATCOM has recently received much attention owing to its ability to stabilize power systems and mitigate voltage variations. This paper investigates a novel interval type-II fuzzy rule-based PID (proportional-integral-derivative controller for the STATCOM to mitigate bus voltage variations caused by large changes in load and the intermittent generation of photovoltaic (PV arrays. The proposed interval type-II fuzzy rule base utilizes the output of the PID controller to tune the signal applied to the STATCOM. The rules involve upper and lower membership functions that ensure the stable responses of the controlled system. The proposed method is implemented using the NEPLAN software package and MATLAB/Simulink with co-simulation. A six-bus system is used to show the effectiveness of the proposed method. Comparative studies show that the proposed method is superior to traditional PID and type-I fuzzy rule-based methods.

  17. Influence of intellectual impairment (II on basketball players´ capacity to solve a game situation: towards evidence-based classification systems in II-basketball

    Directory of Open Access Journals (Sweden)

    Javier PINILLA

    2016-07-01

    Full Text Available Basketball for athletes with intellectual impairment (II requires the development of evidence-based eligibility systems to guarantee that only athletes with significant limitations performing basketball participate in these competitions. In addition, this is needed to re-include IIbasketball in the Paralympic program. To do this, it is required to investigate how II impacts on fundamental basketball activities. To address this need, the aim of this study was to compare ablebodied (AB and II-players´ capacity to solve a game situation. A field test was designed ad hoc in which 38 elite II-players from France, Portugal, Australia and Japan who participated in the Global Games (2015 and 38 AB-basketball players competing in Spanish competitions, had to solve 8 standardized game situations. Results indicated that II-players spent significantly (p≤0.05 more time to decide (0.92±0.2s than AB-players (0.63±0.1s and to execute the solution (II: 3.01±0.4s; AB: 2.56±0.3s. Also, II-players made more rule infractions (II: 7.11±1.4; AB: 7.71±0.7, more feints (II:1.37±1.4; AB: 0.3±0.6, more dribbles (II: 15.08±3.9; AB: 12.29±2.3 and they performed less successful solutions (II: 4.42±1.5; AB: 5.39±1.3. However, no differences were found in number of correct decisions made. Decision time, number of dribbles and situations in which they succeeded were the variables that best discriminated between II and AB-players. These results confirmed the negative influence of II on players´ capacity to solve a basketball game situation. The calculated discriminant function let us establish the minimum scores from this test that indicates significant limitations on the capacity to solve a game situation. These scores are applicable to determine eligibility criteria in IIbasketball worldwide.

  18. 76 FR 11774 - Paulding Wind Farm II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2011-03-03

    ... Energy Regulatory Commission Paulding Wind Farm II LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of Paulding Wind Farm II LLC's application for market-based rate authority... filings in the above-referenced proceeding are accessible in the Commission's eLibrary system by clicking...

  19. 75 FR 70743 - Seneca Energy, II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2010-11-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Seneca Energy, II LLC; Supplemental Notice That Initial Market- Based Rate... notice in the above-referenced proceeding Seneca Energy, II LLC's application for market-based...

  20. 77 FR 6109 - Bishop Hill Energy II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-02-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Bishop Hill Energy II LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of Bishop Hill Energy II LLC's application for market-based rate...

  1. 76 FR 67721 - Bishop Hill Energy II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2011-11-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Bishop Hill Energy II LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of Bishop Hill Energy II LLC's application for market-based rate...

  2. 77 FR 42721 - Limon Wind II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2012-07-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Limon Wind II, LLC; Supplemental Notice That Initial Market- Based Rate...-referenced proceeding, of Limon Wind II, LLC's application for market-based rate authority, with an...

  3. 78 FR 61946 - Pheasant Run Wind II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2013-10-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Pheasant Run Wind II, LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding, of Pheasant Run Wind II, LLC's application for market-based rate...

  4. Dual-nanomaterial based electrode for voltammetric stripping of trace Fe(II) in coastal waters.

    Science.gov (United States)

    Lin, Mingyue; Pan, Dawei; Zhu, Yun; Hu, Xueping; Han, Haitao; Wang, ChenChen

    2016-07-01

    In this work, a dual-nanomaterial based electrode was established for selective and sensitive detection of trace Fe(II) in the presence of complexing agent (2,2'-bipyridyl). Titanium carbide nanoparticles (TiCNPs) were used as the growth-template for the formation of three-dimensional platinum nanoflowers (PtNFs) due to their unique cubic structures. Nafion was employed as the conducting matrix to help TiCNPs better attached onto the surface of the electrode and slow down the crystal rate of PtNFs during electrodeposition, which resulted in flower structure and more active surface of PtNFs. Taking advantage of synergistic effects of TiCNPs and Nafion as well as the catalytic amplifying effect of PtNFs, the excellent anodic signal responses for the voltammetric stripping determination of Fe(II) were obtained. The linear range of Fe(II) on this dual-nanomaterial based electrode was from 1nmolL(-1) to 6μmolL(-1) with the lowest detectable concentration of 0.1nmolL(-1) and a detection limit of 0.03nmolL(-1). Additionally, the effect of several experimental parameters, such as concentration and pH value of buffer solution, concentration of modifier and ligand, deposition potential and time of electrochemical determination, and scan rate were studied for analytical applications. The fabricated sensor had been successfully applied for the sensitive determination of trace Fe(II) in coastal waters.

  5. Isolation of four new CoII/CoIII and NiII complexes with a pentadentate Schiff base ligand: syntheses, structural descriptions and magnetic studies.

    Science.gov (United States)

    Banerjee, Sambuddha; Nandy, Madhusudan; Sen, Soma; Mandal, Sandip; Rosair, Georgina M; Slawin, Alexandra M Z; Gómez García, Carlos J; Clemente-Juan, Juan M; Zangrando, Ennio; Guidolin, Nicol; Mitra, Samiran

    2011-02-28

    In this paper we report the temperature and pH dependent syntheses and systematic characterization of four new Co(II)/Co(III) and Ni(II) complexes with a pentadentate Schiff base ligand H(3)L obtained by condensing 1,3,-diaminopropan-2-ol with 2-hydroxyacetophenone in 1:2 molar ratio. The room temperature syntheses involving Co(II) and Ni(II) nitrates and the ligand H(3)L lead to the isolation of the dinuclear species [Co(2)L(2)(H(2)O)] (1), and the mononuclear complex [Ni(LH)] (3), respectively, whereas refluxing at basic pH leads to the tetranuclear complexes, [Co(II)(2)Co(III)(2)L(2)(μ(3)-OMe)(2)(NO(3))(H(2)O)(2)]NO(3)·2(H(2)O) (2), and [Ni(4)L(2)(μ(3)-OMe)(2)(H(2)O)(2)]·2H(2)O (4). 1 is found to be a simple mono alkoxo-bridged Co(III) dinuclear species, whereas 2 and 4 are both rhomb-like tetrameric complexes with double oxo bridges and μ(3)-methoxo bridges, derived from the methanol solvent, in an open dicubane arrangement. Moreover 2 shows six coordinate ordered Co(II) and Co(III) ions and 4 has both six- and five-coordinate Ni(II) centers. Compound 3 is assigned a tentative mononuclear structure based on IR, UV-Vis spectroscopic, (1)H-NMR and ESI mass study results and is supposed to have one Ni(II) center coordinated with a ligand fragment in square planar geometry. The variable temperature magnetic susceptibility study for 2 and 4 is performed which indicate for both 2 and 4 the presence of intracluster dominant ferromagnetic interactions.

  6. Structural, Spectroscopic and Biological Aspects of O, N- Donor Schiff Base Ligand and its Cr(III, Co(II, Ni(II and Cu(II Complexes Synthesized through Green Chemical Approach

    Directory of Open Access Journals (Sweden)

    Kavita Rathore

    2010-01-01

    Full Text Available The monofunctional bidentate Schiff base ligand (o-vanillin p-chloroaniline and its four new complexes of chromium(III, cobalt(II, nickel(II and copper(II have been synthesized by classical thermal and microwave-irradiated techniques. All the new derivatives have been characterized by elemental analysis, molecular weight determinations, molar conductance measurements, UV-Vis, IR and NMR spectral studies. The IR spectral data suggest the involvement of phenolic oxygen after deprotonation and azomethine nitrogen in coordination to the central metal ion. The growth inhibiting potential of the ligands and complexes has been assessed against a variety of fungal and bacterial strains.

  7. Synthesis, physical characterization and biological evaluation of Schiff base M(II complexes

    Directory of Open Access Journals (Sweden)

    Mahasin Alias

    2014-04-01

    Full Text Available Metal (II complexes of Cu, Ni, and Co with Schiff base derived from potassium 2-N (4-N,N-dimethylaminobenzyliden- 4-trithiocarbonate 1,3,4-thiadiazole (L were synthesized and characterized by standard physico-chemical procedures i.e. (metal analysis A.A, elemental chemical analysis C.H.N.S, FTIR, UV–vis, thermal analysis TGA, magnetic susceptibility and conductometric measurements. On the basis of these studies, a six coordinated octahedral geometry for all these complexes has been proposed. The Schiff base ligand and its complexes were also tested for their antibacterial activity to assess their inhibiting potential against Pseudomonas aeruginosa (as gram negative bacteria and Staphylococcus aureus (as gram positive bacteria using two different concentrations (5 and 10 mM. The results showed the Ni(II complex have the higher rate in antibacterial activity than other complexes and ligand when compared them with ampicillin as standard drug.

  8. A novel Schiff-base as a Cu(II) ion fluorescent sensor in aqueous solution.

    Science.gov (United States)

    Gündüz, Z Yurtman; Gündüz, C; Özpınar, C; Urucu, O Aydın

    2015-02-05

    A new fluorescent Cu(II) sensor (L) obtained from the Schiff base of 5,5'-methylene-bis-salicylaldehyde with amidol (2,4-diaminophenol) was synthesized and characterized by FT-IR, MS, (1)H NMR, (13)C NMR techniques. In the presence of pH 6.5 (KHPO4-Na2HPO4) buffer solutions, copper reacted with L to form a stable 2:1 complex. Fluorescence spectroscopic study showed that Schiff base is highly sensitive towards Cu(II) over other metal ions (K(+), Na(+), Al(3+), Ni(2+), Co(2+), Fe(3+), Zn(2+), Pb(2+)) in DMSO/H2O (30%, v/v). The sensor L was successfully applied to the determination of copper in standard reference material. The structural properties and molecular orbitals of the complex formed between L and Cu(2+) ions were also investigated using quantum chemical computations.

  9. Synthesis and characterization of novel nano-chitosan Schiff base and use of lead (II) sensor.

    Science.gov (United States)

    Kocak, Nuriye; Sahin, Mustafa; Kücükkolbasi, Semahat; Erdogan, Zehra Ozden

    2012-12-01

    A new kind of nano-chitosan Schiff base ligand (CHNS) with particle size of 34 nm was formed by the reaction between the 2-amino groups of glucosamine residue of nano-chitosan and a 2,5-dihydroxybenzaldehyde. The chemical structures of the nano-chitosan and nano-chitosan Schiff base were characterized by FT-IR spectra, particle sizer, zeta potential, and elemental analysis. A new, simple and effective chemically modified carbon paste electrode with CHNS was prepared and used as a lead (II) sensor. The prepared electrode was characterized using scanning electronic microscopy (SEM-EDX) and cyclic voltammetry (CV). The modified electrode showed only one oxidation peak in the anodic scan at -0.34 V (vs. Ag/AgCl) for the oxidation of lead (II). The dedection limit (LOD) was calculated as 1.36×10(-7) for a 10-min preconcentration time at pH 6.0.

  10. Robust optical oxygen sensors based on polymer-bound NIR-emitting platinum(II)-benzoporphyrins

    DEFF Research Database (Denmark)

    Hutter, L.H.; Müller, B.J.; Koren, Klaus

    2014-01-01

    Several advanced optical oxygen sensor materials are presented. They are based on bright NIR-emitting platinum(II)-benzoporphyrins covalently incorporated into a variety of polymeric matrices. The dye-polymer conjugates are prepared either via Suzuki coupling of the brominated porphyrins to the s......Several advanced optical oxygen sensor materials are presented. They are based on bright NIR-emitting platinum(II)-benzoporphyrins covalently incorporated into a variety of polymeric matrices. The dye-polymer conjugates are prepared either via Suzuki coupling of the brominated porphyrins...... dyes showed significant drift of their calibration. Additionally, we present a new synthetic method for preparation of analytically pure benzoporphyrins via simple 1-step template condensation which a promising alternative to the commonly used Lindsey method. © the Partner Organisations 2014....

  11. New highly fluorescent biolabels based on II VI semiconductor hybrid organic inorganic nanostructures for bioimaging

    Science.gov (United States)

    Santos, B. S.; Farias, P. M. A.; Menezes, F. D.; Brasil, A. G., Jr.; Fontes, A.; Romão, L.; Amaral, J. O.; Moura-Neto, V.; Tenório, D. P. L. A.; Cesar, C. L.; Barbosa, L. C.; Ferreira, R.

    2008-11-01

    Semiconductor quantum dots based on II-VI materials may be prepared to develop good biolabeling properties. In this study we present some well-succeeded results related to the preparation, functionalization and bioconjugation of CdY (Y = S, Se and Te) to biological systems (live cells and fixed tissues). These nanostructured materials were prepared using colloidal synthesis in aqueous media resulting nanoparticles with very good optical properties and an excellent resistance to photodegradation.

  12. Starting a hospital-based home health agency: Part II--Key success factors.

    Science.gov (United States)

    Montgomery, P

    1993-09-01

    In Part II of a three-part series, the financial, technological and legislative issues of a hospital-based home health-agency are discussed. Beginning a home healthcare service requires intensive research to answer key environmental and operational questions--need, competition, financial projections, initial start-up costs and the impact of delayed depreciation. Assessments involving technology, staffing, legislative and regulatory issues can help project service volume, productivity and cost-control.

  13. Electrochemical capacitors based on nitrogen-enriched cobalt (II) phthalocyanine/multi-walled carbon nanotube nanocomposites

    CSIR Research Space (South Africa)

    Lekitima, JN

    2013-11-01

    Full Text Available Based on Nitrogen-Enriched Cobalt (II) Phthalocyanine/Multi-walled Carbon Nanotube Nanocomposites Joel N. Lekitimaa, Kenneth I. Ozoemenaa,b,*, and Nagao Kobayashic a Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa... non faradaic processes (double layer capacitance) and/or non faradaic processes (pseudo-capacitance). Various carbon materials such as carbon nanotubes CNTs) and activated carbons (ACs), because of their high surface area have been widely used...

  14. Dimensional optimization of a minimally invasive surgical robot system based on NSGA-II algorithm

    OpenAIRE

    Wei Wang; Weidong Wang; Wei Dong; Hongjian Yu; Zhiyuan Yan; Zhijiang Du

    2015-01-01

    Based on the proposed end-effector structure of a laparoscopic minimally invasive surgical manipulator, a dimensional optimization method is investigated to enlarge the motion range of the mechanical arm in the specific target area and reduce the collision among the mechanical arms simultaneously. Both the length of the kinematics links and the overall size of the integrated system are considered in the optimization process. The NSGA-II algorithm oriented to the multi-objective optimization i...

  15. A ruthenium(II) complex as turn-on Cu(II) luminescent sensor based on oxidative cyclization mechanism and its application in vivo

    Science.gov (United States)

    Zhang, Yunfei; Liu, Zonglun; Yang, Kui; Zhang, Yi; Xu, Yongqian; Li, Hongjuan; Wang, Chaoxia; Lu, Aiping; Sun, Shiguo

    2015-02-01

    Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this paper, a novel water-soluble ruthenium(II) complex as a turn-on copper(II) ions luminescent sensor based on o-(phenylazo)aniline was designed and synthesized. The azo group would undergo a specific oxidative cyclization reaction with copper(II) ions and turn into high luminescent benzotriazole, triggering significant luminescent increasements which were linear to the concentrations of copper(II) ions. The sensor distinguished by its high sensitivity (over 80-fold luminescent switch-on response), good selectivity (the changes of the emission intensity in the presence of other metal ions or amino acids were negligible) and low detection limit (4.42 nM) in water. Moreover, the copper(II) luminescent sensor exhibited good photostability under light irradiation. Furthermore, the applicability of the proposed sensor in biological samples assay was also studied and imaged copper(II) ions in living pea aphids successfully.

  16. Copper(II) Schiff base complexes and their mixed thin layers with ZnO nanoparticles

    Indian Academy of Sciences (India)

    MAGDALENA BARWIOLEK; ROBERT SZCZĘSNY; EDWARD SZŁYK

    2016-07-01

    Cu(II) complexes with Schiff bases derived from ethylenediamine (en) and 2-pyridinecarboxaldehyde (pyca), 2,5-dimethoxybenzaldehyde (dmbaH) or 4-imidazolecarboxaldehyde (4Him) were obtained and studied by elemental analysis, UV-VIS and IR spectra. Zinc oxide was synthesized using a simple homogeneous precipitation method with zinc acetate as a starting material. Thin layers of the studied Cu(II) complexes were deposited on Si(111) or ZnO/Si(111) substrates by a spin coating method and characterized with a scanningelectron microscopy (SEM/EDS), atomic force microscopy (AFM) and fluorescence spectroscopy. For Cu(II) layers the most intensive fluorescence bands due to intra-ligand transitions were observed between 462 and 503 nm. The fluorescence intensity of thin layers was corelated to the rotation speed. In the case of the [Cu(II)(en(4Him)₂)Cl₂](2a)/ZnO/Si and [Cu(en(dmbaH)₂)Cl₂](3a)/ZnO/Si layers the quenching of the emission band from ZnO at 440 nm (λex = 330 nm) associated with various intrinsic or extrinsic lattice defects was noted.

  17. Development of urease based amperometric biosensors for the inhibitive determination of Hg (II).

    Science.gov (United States)

    Domínguez-Renedo, O; Alonso-Lomillo, M A; Ferreira-Gonçalves, L; Arcos-Martínez, M J

    2009-10-15

    Enzymatic amperometric procedures for measurement of Hg (II), based on the inhibitive action of this metal on urease enzyme activity, were developed. Screen-printed carbon electrodes (SPCEs) and gold nanoparticles modified screen-printed carbon electrodes (AuNPs/SPCEs) were used as supports for the cross-linking inmobilization of the enzyme urease. The amperometric response of urea was affected by the presence of Hg (II) ions which caused a decreasing in the current intensity. The optimum working conditions were found using experimental design methodology. Under these conditions, repeatability and reproducibility for both types of biosensors were determined, reaching values below 6% in terms of residual standard deviation. The detection limit obtained for Hg (II) was 4.2x10(-6)M for urease/SPCE biosensor and 5.6x10(-8)M for urease/AuNPs/SPCE biosensor. Analysis of the possible effect of the presence of foreign ions in the solution was performed. The method was applied to determine levels of Hg (II) in spiked human plasma samples.

  18. Data acquisition system based on the Nios II for a CCD camera

    Science.gov (United States)

    Li, Binhua; Hu, Keliang; Wang, Chunrong; Liu, Yangbing; He, Chun

    2006-06-01

    The FPGA with Avalon Bus architecture and Nios soft-core processor developed by Altera Corporation is an advanced embedded solution for control and interface systems. A CCD data acquisition system with an Ethernet terminal port based on the TCP/IP protocol is implemented in NAOC, which is composed of a piece of interface board with an Altera's FPGA, 32MB SDRAM and some other accessory devices integrated on it, and two packages of control software used in the Nios II embedded processor and the remote host PC respectively. The system is used to replace a 7200 series image acquisition card which is inserted in a control and data acquisition PC, and to download commands to an existing CCD camera and collect image data from the camera to the PC. The embedded chip in the system is a Cyclone FPGA with a configurable Nios II soft-core processor. Hardware structure of the system, configuration for the embedded soft-core processor, and peripherals of the processor in the PFGA are described. The C program run in the Nios II embedded system is built in the Nios II IDE kits and the C++ program used in the PC is developed in the Microsoft's Visual C++ environment. Some key techniques in design and implementation of the C and VC++ programs are presented, including the downloading of the camera commands, initialization of the camera, DMA control, TCP/IP communication and UDP data uploading.

  19. Efficient Synthesis and Characterization of Some Novel Nitro-Schiff Bases and Their Complexes of Nickel(II and Copper(II

    Directory of Open Access Journals (Sweden)

    Hossein Naeimi

    2013-01-01

    Full Text Available Synthesis and characterization of some new Schiff base ligands derived from various diamines and nitrosalicylaldehyde and their complexes of Ni(II and Cu(II are reported. Several spectral techniques such as UV-Vis, FT-IR, and NMR spectra were used to identify the chemical structures of the reported ligands and their complexes. The ligands are found to be bound to the metal atom through the oxygen atoms of the hydroxyl groups and nitrogen atoms of imine groups, which is also supported by spectroscopic techniques. The results obtained by FT-IR and NMR showed that the Schiff base complexes of transition metal (II have square-planar geometry.

  20. Synthesis, characterization, electrochemical and biological studies on some metal(II) Schiff base complexes containing quinoxaline moiety

    Science.gov (United States)

    Justin Dhanaraj, Chellaian; Johnson, Jijo

    2014-01-01

    Novel Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff base derived from quinoxaline-2,3-(1,4H)-dione and 4-aminoantipyrine (QDAAP) were synthesized. The ligand and its complexes were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, FTIR, UV-Vis., mass and 1H NMR spectral studies. The X band ESR spectrum of the Cu(II) complex at 300 and 77 K were also recorded. Thermal studies of the ligand and its complexes show the presence of coordinated water in the Ni(II) and Zn(II) complexes. The coordination behavior of QDAAP is also discussed. All the complexes are mono nuclear and tetrahedral geometry was found for Co(II) complex. For the Ni(II) and Zn(II) complexes, octahedral geometry was assigned and for the Cu(II) complex, square planar geometry has been suggested. The grain size of the complexes was estimated using powder XRD. The surface morphology of the compounds was studied using SEM analysis. Electrochemical behavior of the synthesized complexes in DMF at room temperature was investigated by cyclic voltammetry. The in vitro biological screening of QDAAP and its metal complexes were tested against bacterial species Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The fungal species include Aspergillus niger, Aspergillus flavus and Candida albicans. The DNA cleavage activity of QDAAP and its complexes were also discussed.

  1. Design, synthesis and characterization of macrocyclic ligand based transition metal complexes of Ni(II), Cu(II) and Co(II) with their antimicrobial and antioxidant evaluation

    Science.gov (United States)

    Gull, Parveez; Malik, Manzoor Ahmad; Dar, Ovas Ahmad; Hashmi, Athar Adil

    2017-04-01

    Three new complexes Ni(II), Cu(II) and Co(II) were synthesized of macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and O-phthalaldehyde in the ratio of 2:2. The synthesized compounds were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, FTIR, UV-Vis., Mass and 1H NMR spectral studies. The electronic spectra of the metal complexes indicate a six coordinate octahedral geometry of the central metal ion. These metal complexes and the ligand were evaluated for antimicrobial activity against bacteria (E. coli, B. subtilis, S. aureus) and fungi (A. niger, A. flavus, C. albicans) and compared against standard drugs chloramphenicol and nystatin respectively. In addition, the antioxidant activity of the compounds was also investigated through scavenging effect on DPPH radicals.

  2. Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II).

    Science.gov (United States)

    Joseyphus, R Selwin; Nair, M Sivasankaran

    2008-06-01

    Two Schiff base ligands L1and L2 were obtained by the condensation of glycylglycine respectively with imidazole-2-carboxaldehyde and indole-3-carboxaldehyde and their complexes with Zn(II) were prepared and characterized by microanalytical, conductivity measurement, IR, UV-Vis., XRD and SEM. The molar conductance measurement indicates that the Zn(II) complexes are 1: 1electrolytes. The IR data demonstrate the tetradentate binding of L1and tridentate binding of L2. The XRD data show that Zn(II) complexes with L1and L2 have the crystallite sizes of 53 and 61nm respectively. The surface morphology of the complexes was studied using SEM. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the disc diffusion method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. Zinc ions are proven to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

  3. Synthesis, Spectroscopy, Theoretical, and Electrochemical Studies of Zn(II, Cd(II, and Hg(II Azide and Thiocyanate Complexes of a New Symmetric Schiff-Base Ligand

    Directory of Open Access Journals (Sweden)

    Morteza Montazerozohori

    2013-01-01

    Full Text Available Synthesis of zinc(II/cadmium(II/mercury(II thiocyanate and azide complexes of a new bidentate Schiff-base ligand (L with general formula of MLX2 (M = Zn(II, Cd(II, and Hg(II in ethanol solution at room temperature is reported. The ligand and metal complexes were characterized by using ultraviolet-visible (UV-visible, Fourier transform infrared (FT-IR, 1H- and 13C-NMR spectroscopy and physical characterization, CHN analysis, and molar conductivity. 1H- and 13C-NMR spectra have been studied in DMSO-d6. The reasonable shifts of FT-IR and NMR spectral signals of the complexes with respect to the free ligand confirm well coordination of Schiff-base ligand and anions in an inner sphere coordination space. The conductivity measurements as well as spectral data indicated that the complexes are nonelectrolyte. Theoretical optimization on the structure of ligand and its complexes was performed at the Becke’s three-parameter hybrid functional (B3 with the nonlocal correlation of Lee-Yang-Parr (LYP level of theory with double-zeta valence (LANL2DZ basis set using GAUSSIAN 03 suite of program, and then some theoretical structural parameters such as bond lengths, bond angles, and torsion angles were obtained. Finally, electrochemical behavior of ligand and its complexes was investigated. Cyclic voltammograms of metal complexes showed considerable changes with respect to free ligand.

  4. Selective chemosensor for Hg(II) ions based on tris[2-(4-phenyldiazenyl)phenylaminoethoxy]cyclotriveratrylene in aqueous samples

    NARCIS (Netherlands)

    Nuriman, [Unknown; Kuswandi, Bambang; Verboom, Willem

    2009-01-01

    A novel chemosensor, based on tris[2-(4-phenyldiazenyl)phenylaminoethoxy]cyclotriveratrylene (TPPECTV) as chromophore, has been developed for the colorimetric determination and visual detection of Hg(II) ions. TPPECTV exhibits a pronounced chromogenic behavior toward Hg(II) ions by changing the colo

  5. Bioinorganic Relevance of Some Cobalt(II Complexes with Thiophene-2-glyoxal Derived Schiff Bases

    Directory of Open Access Journals (Sweden)

    Prashant Singh

    2009-01-01

    Full Text Available Complexes of Co(II with two new Schiff bases TEAB [2-hydroxy-4-{[2-oxo-2-(thiophen-2-ylethylidene]amino}benzoic acid] and TEPC [N-[2-oxo-2-(thiophen-2-ylethylidene]pyridine-3-carboxamide] have been synthesized and characterized with the help of elemental analysis, magnetic, mass, 1H-NMR, 13C-NMR, IR and electronic spectral data. IR spectra manifest the coordination of the ligand to the metal ion through the carbonyl oxygen, azomethine nitrogen and thienyl sulphur atoms. With the help of electronic spectral data various ligand field parameters were also calculated. All these studies reveal the distorted octahedral Co(II complexes. Synthesized compounds have also been screened against some micro organisms viz, Escherichia coli, Proteus vulgaris, Aspergillus niger and Aspergillus flavus with the help of ‘filter paper disc’ technique. It has been observed that the antimicrobial activities of metal complexes are higher than that of the free ligand.

  6. Physical and chemical bases of synthesis of cobalt(II sulfide in the reverse microemulsion

    Directory of Open Access Journals (Sweden)

    Teslyuk D.A.

    2015-03-01

    Full Text Available This paper presents the research results of stability of reverse microemulsion which consists of sodium dodecyl sulfate (SDS / n-butanol – water – heptane in the presence of an aqueous phase dissolved cobalt(II sulfate and sodium sulfide. The results of the spectrophotometric and conductometric studies of microemulsion have been presented. The dependence of reverse microemulsion electrical conductivity and optical density on the phase relation has been indicated. Based on these results some assumptions of the ongoing structural changes in the microemulsions have been made. Thermodynamic calculation describing boundary formation of cobalt(II sulfide precipitate in aqueous solution depending on pH has been carried out, the competing hydrolysis reactions have been estimated

  7. Beam-based calibrations of the BPM offset at C-ADS Injector II

    Science.gov (United States)

    Chen, Wei-Long; Wang, Zhi-Jun; Feng, Chi; Dou, Wei-Ping; Tao, Yue; Jia, Huan; Wang, Wang-Sheng; Liu, Shu-Hui; He, Yuan

    2016-07-01

    Beam-based BPM offset calibration was carried out for Injector II at the C-ADS demonstration facility at the Institute of Modern Physics (IMP), Chinese Academy of Science (CAS). By using the steering coils integrated in the quadrupoles, the beam orbit can be effectively adjusted and BPM positions recorded at the Medium Energy Beam Transport of the Injector II Linac. The studies were done with a 2 mA, 2.1 MeV proton beam in pulsed mode. During the studies, the “null comparison method” was applied for the calibration. This method is less sensitive to errors compared with the traditional transmission matrix method. In addition, the quadrupole magnet’s center can also be calibrated with this method. Supported by National Natural Science Foundation of China (91426303, 11525523)

  8. Schiff base triphenylphosphine palladium (II) complexes: Synthesis, structural elucidation, electrochemical and biological evaluation

    Science.gov (United States)

    Shabbir, Muhammad; Akhter, Zareen; Ahmad, Iqbal; Ahmed, Safeer; Shafiq, Maryam; Mirza, Bushra; McKee, Vickie; Munawar, Khurram Shahzad; Ashraf, Ahmad Raza

    2016-08-01

    The complexes N-(2-oxidophenyl)salicylideneiminatotriphenylphosphine palladium(II) (1) and N-(2-sulfidophenyl)salicylideneiminato triphenylphosphine palladium(II) (2) of tridentate Schiff bases derived from salicylaldehyde and an amino- or thiophenol, have been synthesized and characterized by various spectroscopic, analytical and electro-analytical techniques. X-ray single crystal analysis of complex 1 has revealed its square planar geometry. The thermal analysis has shown the absence of coordinated water and final degradation product is PdO. The alkaline phosphatase studies have indicated that enzymatic activity is concentration dependent which is inversely proportional to the concentration of the compounds. The biological assays (brine shrimp cytotoxicity, DPPH) have reflected their biologically active and mild antioxidant nature. However, results of DNA protection assay have shown that they possess moderate protective activity against hydroxyl free radicals (rad OH). The voltammetric studies ascertain two-electron reduction of the compounds through purely diffusion controlled process and reveal intercalative mode of drug DNA interactions.

  9. Conscientiousness and mindfulness in midlife coping: An assessment based on MIDUS II.

    Science.gov (United States)

    Sesker, Amanda A; Súilleabháin, Páraic Ó; Howard, Siobhán; Hughes, Brian M

    2016-02-01

    Research has demonstrated that conscientious individuals tend to engage in planful problem solving to cope with stressful situations. Likewise, mindful individuals tend to favour approach-based coping and are less likely to engage in avoidant coping strategies. To examine whether conscientiousness and mindfulness determined agentic coping behaviour, hierarchical linear regressions were conducted using data from 602 participants drawn from the National Survey of Midlife Development in the United States (MIDUS) Study II and MIDUS II Biomarker Project. Personality responses were derived from the five-factor model inventory, gathered at a single time-point. Results revealed that conscientiousness predicted problem-focused coping (p conscientiousness and mindfulness may contribute to coping responses in potentially healthful ways, highlighting new evidence regarding the potential protective role of conscientiousness.

  10. A simple method for determining water content in organic solvents based on cobalt(II) complexes

    Institute of Scientific and Technical Information of China (English)

    Lin Zhou; Xiao Hua Liu; Hai Xin Bai; Hong Juan Wang

    2011-01-01

    A method to determine water content in organic solvents was developed based on the color change of cobalt(II) nitrate in different solvents. The color-change mechanism and optimal conditions for determining the water content were investigated. The results showed that there was a good linear relationships between the absorbance of cobalt(II) complexes in organic solvents and water contents with y in 0.9989~0.9994. This method has the advantages of low cost, good reproducibility, good sensitivity, simple in operation, fast in detection, friendly to the environment and no limitation on linear range for determining water content. It was used to determine water in samples with a satisfactory recovery in 97.81%~101.24%.

  11. Luminescent liquid crystalline materials based on palladium(II) imine derivatives containing the 2-phenylpyridine core.

    Science.gov (United States)

    Micutz, Marin; Iliş, Monica; Staicu, Teodora; Dumitraşcu, Florea; Pasuk, Iuliana; Molard, Yann; Roisnel, Thierry; Cîrcu, Viorel

    2014-01-21

    In this work we report our studies concerning the synthesis and characterisation of a series of imine derivatives that incorporate the 2-phenylpyridine (2-ppy) core. These derivatives were used in the cyclometalating reactions of platinum(II) or palladium(II) in order to prepare several complexes with liquid crystalline properties. Depending on the starting materials used as well as the solvents employed, different metal complexes were obtained, some of them showing both liquid crystalline behaviour and luminescence properties at room temperature. It was found that, even if there are two competing coordination sites, the cyclometalation process takes place always at the 2-ppy core with (for Pt) or without (for Pd) the imine bond cleavage. We successfully showed that it is possible to prepare emissive room temperature liquid crystalline materials based on double cyclopalladated heteroleptic complexes by varying the volume fraction of the long flexible alkyl tails on the ancillary benzoylthiourea (BTU) ligands.

  12. Simultaneous trace-levels determination of Hg(II) and Pb(II) ions in various samples using a modified carbon paste electrode based on multi-walled carbon nanotubes and a new synthesized Schiff base.

    Science.gov (United States)

    Afkhami, Abbas; Bagheri, Hasan; Khoshsafar, Hosein; Saber-Tehrani, Mohammad; Tabatabaee, Masoumeh; Shirzadmehr, Ali

    2012-10-09

    A modified carbon paste electrode based on multi-walled carbon nanotubes (MWCNTs) and 3-(4-methoxybenzylideneamino)-2-thioxothiazolodin-4-one as a new synthesized Schiff base was constructed for the simultaneous determination of trace amounts of Hg(II) and Pb(II) by square wave anodic stripping voltammetry. The modified electrode showed an excellent selectivity and stability for Hg(II) and Pb(II) determinations and for accelerated electron transfer between the electrode and the analytes. The electrochemical properties and applications of the modified electrode were studied. Operational parameters such as pH, deposition potential and deposition time were optimized for the purpose of determination of traces of metal ions at pH 3.0. Under optimal conditions the limits of detection, based on three times the background noise, were 9.0×10(-4) and 6.0×10(-4) μmol L(-1) for Hg(II) and Pb(II) with a 90 s preconcentration, respectively. In addition, the modified electrode displayed a good reproducibility and selectivity, making it suitable for the simultaneous determination of Hg(II) and Pb(II) in real samples such as sea water, waste water, tobacco, marine and human teeth samples.

  13. Synthesis, spectroscopic characterization, DFT optimization and biological activities of Schiff bases and their metal (II) complexes

    Science.gov (United States)

    Rauf, Abdur; Shah, Afzal; Munawar, Khurram Shahzad; Khan, Abdul Aziz; Abbasi, Rashda; Yameen, Muhammad Arfat; Khan, Asad Muhammad; Khan, Abdur Rahman; Qureshi, Irfan Zia; Kraatz, Heinz-Bernhard; Zia-ur-Rehman

    2017-10-01

    A Novel Schiff base, 3-(((4-chlorophenyl)imino)methyl)benzene-1,2-diol (HL1) was successfully synthesized along with a structurally similar Schiff base 3-(((4-bromophenyl)imino)methyl)benzene-1,2-diol (HL2). Both the Schiff bases were used to synthesize their zinc (II) and cobalt (II) complexes. These compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analysis. Metal complexes were confirmed by TGA. Crystals of Schiff bases were also characterized by X-ray analysis and experimental parameters were found in line with the theoretical parameters. Quantum mechanical approach was also used to fine useful structural parameters and to ensure the geometry of metal complexes. The photometric behaviors of all the synthesized compounds were investigated in a wide pH range using BR buffers. The appearance of isosbestic points indicated the existence of Schiff bases in more than one isomeric form. Moreover, these compounds were screened for enzyme inhibition; antibacterial, cytotoxic and in vivo antidiabetic activities and compounds were found active against one or other activity. Results indicate that ZnL22 is a good inhibitor of alkaline phosphatase enzyme and possess highest potential against diabetes, blood cholesterol level and cancer cells. This effort just provides preliminary data for some biological properties. Further investigations are required to precisely determine mechanistic pathways of their use towards drug development.

  14. Palladium(II) and zinc(II) complexes of neutral [N2O2] donor Schiff bases derived from furfuraldehyde: Synthesis, characterization, fluorescence and corrosion inhibitors of ligands

    Science.gov (United States)

    Ali, Omyma A. M.

    2014-11-01

    Metal complexes of Schiff bases derived from furfuraldehyde and 4,5-dimethyl-1,2-phenylendiamine (L1) or 4,5-dichloro-1,2-phenylendiamine (L2) have been reported and characterized based on elemental analyses, IR, 1H NMR, UV-Vis, magnetic moment, molar conductance and thermal analysis. The complexes are found to have the formulae [PdL1-2]Cl2 and [ZnL1-2](AcO)2·H2O. The molar conductance data reveal that Pd(II) and Zn(II) chelates are ionic in nature and are of the type 2:1 electrolytes. The spectral data are consistent with a square planar and tetrahedral geometry around Pd(II) and Zn(II), respectively, in which the ligands act as tetradentate ligands. The thermal behavior of some chelates is studied and the activation thermodynamic parameters are calculated using Coats-Redfern method. The corrosion inhibition of stainless steel types 410 and 304 in 1 M HCl using the synthesized Schiff bases as inhibitors have been studied by weight loss method. The obtained data considered these ligands as efficient corrosion inhibitors. The ligands and their metal complexes exhibited considerable antibacterial activity against Staphylococcusaureus, and Escherichiacoli and antifungal activity against Candida albicans.

  15. Palladium(II) and zinc(II) complexes of neutral [N2O2] donor Schiff bases derived from furfuraldehyde: synthesis, characterization, fluorescence and corrosion inhibitors of ligands.

    Science.gov (United States)

    Ali, Omyma A M

    2014-11-11

    Metal complexes of Schiff bases derived from furfuraldehyde and 4,5-dimethyl-1,2-phenylendiamine (L1) or 4,5-dichloro-1,2-phenylendiamine (L2) have been reported and characterized based on elemental analyses, IR, 1H NMR, UV-Vis, magnetic moment, molar conductance and thermal analysis. The complexes are found to have the formulae [PdL1-2]Cl2 and [ZnL1-2](AcO)2·H2O. The molar conductance data reveal that Pd(II) and Zn(II) chelates are ionic in nature and are of the type 2:1 electrolytes. The spectral data are consistent with a square planar and tetrahedral geometry around Pd(II) and Zn(II), respectively, in which the ligands act as tetradentate ligands. The thermal behavior of some chelates is studied and the activation thermodynamic parameters are calculated using Coats-Redfern method. The corrosion inhibition of stainless steel types 410 and 304 in 1 M HCl using the synthesized Schiff bases as inhibitors have been studied by weight loss method. The obtained data considered these ligands as efficient corrosion inhibitors. The ligands and their metal complexes exhibited considerable antibacterial activity against Staphylococcusaureus, and Escherichiacoli and antifungal activity against Candida albicans.

  16. The calibration of the O/H abundance indicators for extragalactic H II regions based on O II recombination lines

    OpenAIRE

    M. Peimbert; A. Peimbert; Esteban, C.; García-Rojas, J.; Bresolin, F.; Carigi, L.; Ruiz, M. T.; A. R. López

    2007-01-01

    Presentamos una nueva calibración del indicador O23 de Pagel para determinar los cocientes de O/H en regiones H II extra galácticas y galaxias con líneas de emisión. Esta calibración la llamamos O IIRL y esta basada en líneas de recombinación de O II. Nuestra calibración produce abundancias de O/H alrededor de un factor de dos mayores que las obtenidas a partir del método Te(4363) con t2 = 0.00. La calibración O IIRL tiene consecuencias para el estudio de diferentes propiedades de...

  17. Preliminary study of EEHG-based superradiant undulator radiation at the HLS-II storage ring

    Science.gov (United States)

    Gao, Wei-Wei; Li, He-Ting; Wang, Lin

    2017-07-01

    We investigate storage ring-based Echo-Enabled Harmonic Generation (EEHG) superradiant undulator radiation as a possible scheme to obtain shorter wavelengths at the HLS-II (Hefei Light Source-II) storage ring. In this paper we give the designation of the storage ring based EEHG up to the 26th harmonic, where 31 nm vacuum ultraviolet light is radiated from an 800 nm seeded laser. The novelty of our design is that both the two dispersion sections of EEHG are realized by the storage ring’s own magnet structure. In particular, the whole ring is used as the first dispersion section, and two modulators of the traditional EEHG can be done with the same undulator. These two dispersion sections are realized by changing the superperiod of the present lattice structure, and more precisely by changing the focusing strengths of the present structure. Since no additional magnets and chicanes are used, the beam circulates around the storage ring repeatedly, and thus this storage ring-based EEHG can have a higher repetition rate than a linac-based EEHG. Supported by National Natural Science Foundation of China (11305170)

  18. Zinc(II) and Cadmium(II) complexes with N4-coordinate pyrazole based ligand: Syntheses, characterization and structure

    Science.gov (United States)

    Solanki, Ankita; Sadhu, Mehul H.; Kumar, Sujit Baran; Mitra, Partho

    2014-11-01

    A series of six new mononuclear zinc(II) complexes of the type [Zn(X)(dbdmp)]Y (1-6) (X = N3-/NCO-/NCS-, Y = ClO4-/PF6-, and dbdmp = N,N-diethyl-N‧,N‧-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)ethane-1,2-diamine), two binuclear cadmium(II) complexes [{Cd(dbdmp)}2(μ-N3)2](Y)2 (7-8) and three mononuclear cadmium(II) complexes [Cd(NCO)(dbdmp)]Y (Y = ClO4-/PF6-) (9-10) and [Cd(NCS)2(dbdmp)] (11) have been synthesized and characterized by physico-chemical methods. Crystal structures of the complexes [Zn(N3)(dbdmp)]ClO4 (1), [{Cd(dbdmp)}2(μ-N3)2](ClO4)2 (7), [Cd(NCO)(dbdmp)]ClO4 (9) and [Cd(NCS)2(dbdmp)] (11) have been solved by single crystal X-ray diffraction studies and showed that [Zn(N3)(dbdmp)]ClO4 (1) and [Cd(NCO)(dbdmp)]ClO4 (9) have distorted trigonal bipyramidal geometry, [Cd(NCS)2(dbdmp)] (11) and [(dbdmp)Cd(μ-N3)]2(ClO4)2 (7) have distorted octahedral geometry.

  19. Dye-Sensitized Nanocrystalline ZnO Solar Cells Based on Ruthenium(II Phendione Complexes

    Directory of Open Access Journals (Sweden)

    Hashem Shahroosvand

    2011-01-01

    Full Text Available The metal complexes (RuII (phen2(phendione(PF62(1, [RuII (phen(bpy(phendione(PF62 (2, and (RuII (bpy2(phendione(PF62 (3 (phen = 1,10-phenanthroline, bpy = 2,2′-bipyridine and phendione = 1,10-phenanthroline-5,6-dione have been synthesized as photo sensitizers for ZnO semiconductor in solar cells. FT-IR and absorption spectra showed the favorable interfacial binding between the dye-molecules and ZnO surface. The surface analysis and size of adsorbed dye on nanostructure ZnO were further examined with AFM and SEM. The AFM images clearly show both, the outgrowth of the complexes which are adsorbed on ZnO thin film and the depression of ZnO thin film. We have studied photovoltaic properties of dye-sensitized nanocrystalline semiconductor solar cells based on Ru phendione complexes, which gave power conversion efficiency of (η of 1.54% under the standard AM 1.5 irradiation (100 mW cm−2 with a short-circuit photocurrent density (sc of 3.42 mA cm−2, an open-circuit photovoltage (oc of 0.622 V, and a fill factor (ff of 0.72. Monochromatic incident photon to current conversion efficiency was 38% at 485 nm.

  20. Ni(II, Cu(II, AND Zn(II COMPLEXES DERIVED FROM A NEW SCHIFF BASE 2-((Z-(3-METHYLPYRIDIN-2- YLEIMINOMETHYLPHENOL AND SYNTHESIS OF NANO SIZED METAL OXIDE PARTICLES FROM THESE COMPOUNDS

    Directory of Open Access Journals (Sweden)

    Masoumeh Orojloo

    2015-11-01

    Full Text Available Synthesis, spectral identification, and magnetic properties of three complexes of Ni(II, Cu(II, and Zn(II are described. All three compounds have the general formula [M(L2(H2O2], where L = deprotonated phenol in the Schiff base 2-((z-(3-methylpyridin-2-yleiminomethylphenol. The three complexes were synthesized in a one-step synthesis and characterized by elemental analysis, Fourier transform infrared spectroscopy, electronic spectra, X-ray diffraction (XRD, and room temperature magnetic moments. The Cu(II and Ni(II complexes exhibited room temperature magnetic moments of 1.85 B.M. per copper atom and 2.96 B.M. per nickel atom. The X-band electron spin resonance spectra of a Cu(II sample in dimethylformamide frozen at 77 K (liquid nitrogen temperature showed a typical ΔMS = ± 1 transition. The complexes ([M(L2(H2O2] were investigated by the cyclic voltammetry technique, which provided information regarding the electrochemical mechanism of redox behavior of the compounds. Thermal decomposition of the complexes at 750 ºC resulted in the formation of metal oxide nanoparticles. XRD analyses indicated that the nanoparticles had a high degree of crystallinity. The average sizes of the nanoparticles were found to be approximately 54.3, 30.1, and 44.4 nm for NiO, CuO, and ZnO, respectively.

  1. Resistance Torque Based Variable Duty-Cycle Control Method for a Stage II Compressor

    Science.gov (United States)

    Zhong, Meipeng; Zheng, Shuiying

    2017-07-01

    The resistance torque of a piston stage II compressor generates strenuous fluctuations in a rotational period, and this can lead to negative influences on the working performance of the compressor. To restrain the strenuous fluctuations in the piston stage II compressor, a variable duty-cycle control method based on the resistance torque is proposed. A dynamic model of a stage II compressor is set up, and the resistance torque and other characteristic parameters are acquired as the control targets. Then, a variable duty-cycle control method is applied to track the resistance torque, thereby improving the working performance of the compressor. Simulated results show that the compressor, driven by the proposed method, requires lower current, while the rotating speed and the output torque remain comparable to the traditional variable-frequency control methods. A variable duty-cycle control system is developed, and the experimental results prove that the proposed method can help reduce the specific power, input power, and working noise of the compressor to 0.97 kW·m-3·min-1, 0.09 kW and 3.10 dB, respectively, under the same conditions of discharge pressure of 2.00 MPa and a discharge volume of 0.095 m3/min. The proposed variable duty-cycle control method tracks the resistance torque dynamically, and improves the working performance of a Stage II Compressor. The proposed variable duty-cycle control method can be applied to other compressors, and can provide theoretical guidance for the compressor.

  2. Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agent.

    Science.gov (United States)

    Troughton, Jeffrey S; Greenfield, Matthew T; Greenwood, Jaclyn M; Dumas, Stéphane; Wiethoff, Andrea J; Wang, Jufeng; Spiller, Marga; McMurry, Thomas J; Caravan, Peter

    2004-10-04

    The manganese(II) ion has many favorable properties that lead to its potential use as an MRI contrast agent: high spin number, long electronic relaxation time, labile water exchange. The present work describes the design, synthesis, and evaluation of a novel Mn(II) complex (MnL1) based on EDTA and also contains a moiety that noncovalently binds the complex to serum albumin, the same moiety used in the gadolinium based contrast agent MS-325. Ultrafiltration albumin binding measurements (0.1 mM, pH 7.4, 37 degrees C) indicated that the complex binds well to plasma proteins (rabbit: 96 +/- 2% bound, human: 93 +/- 2% bound), and most likely to serum albumin (rabbit: 89 +/- 2% bound, human 98 +/- 2% bound). Observed relaxivities (+/- 5%) of the complex were measured (20 MHz, 37 degrees C, 0.1 mM, pH 7.4) in HEPES buffer (r(1) = 5.8 mM(-)(1) s(-)(1)), rabbit plasma (r(1) = 51 mM(-)(1) s(-)(1)), human plasma (r(1) = 46 mM(-)(1) s(-)(1)), 4.5% rabbit serum albumin (r(1) = 47 mM(-)(1) s(-)(1)), and 4.5% human serum albumin (r(1) = 48 mM(-)(1) s(-)(1)). The water exchange rate was near optimal for an MRI contrast agent (k(298) = 2.3 +/- 0.9 x 10(8) s(-)(1)). Variable temperature NMRD profiles indicated that the high relaxivity was due to slow tumbling of the albumin-bound complex and fast exchange of the inner sphere water. The concept of a high relaxivity Mn(II)-based contrast agent was validated by imaging at 1.5 T. In a rabbit model of carotid artery injury, MnL1 clearly delineated both arteries and veins while also distinguishing between healthy tissue and regions of vessel damage.

  3. δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors.

    Science.gov (United States)

    Ferraris, Dana V; Majer, Pavel; Ni, Chiyou; Slusher, C Ethan; Rais, Rana; Wu, Ying; Wozniak, Krystyna M; Alt, Jesse; Rojas, Camilo; Slusher, Barbara S; Tsukamoto, Takashi

    2014-01-09

    δ-Thiolactones derived from thiol-based glutamate carboxypeptidase II (GCPII) inhibitors were evaluated as prodrugs. In rat liver microsomes, 2-(3-mercaptopropyl)pentanedioic acid (2-MPPA, 1) was gradually produced from 3-(2-oxotetrahydrothiopyran-3-yl)propionic acid (5), a thiolactone derived from 1. Compound 1 was detected in plasma at concentrations well above its IC50 for GCPII following oral administration of 5 in rats. Consistent with the oral plasma pharmacokinetics, thiolactone 5 exhibited efficacy in a rat model of neuropathic pain following oral administration.

  4. Co (II) Complexes with Schiff Base Ligands: Synthesis and EXAFS Study

    Science.gov (United States)

    Mishra, Ashutosh; Mansuri, Amantulla; Ninama, Samrath; Trivedi, Apurva; Patidar, Sushma; Jamod, Mahesh; Awate, Ruchita

    2016-10-01

    Thesynthesis of transition metal Schiff base complexes of Co(II) are prepared by chemical root method. Obtained by the condensation of O-phenylenediamine, salicylaldehyde and isatin / 2-hydroxy- 1 Naphthaldehyde is presented. The complexes were characterized by Co- K- edge EXAFS measurements using the dispersive beam line at 2.5GeV energy of Indus-2 synchrotron radiation source RRCAT Indore. The recorded EXAFS data were analyzed using the computer software Athena for determine the nearest neighboring distances (bond lengths) of these complexes with conventional methods and were compared with Fourier transform (FT) analysis.

  5. Active and passive compensation of APPLE II-introduced multipole errors through beam-based measurement

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Ting-Yi; Huang, Szu-Jung; Fu, Huang-Wen; Chang, Ho-Ping; Chang, Cheng-Hsiang [National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu 30076, Taiwan (China); Hwang, Ching-Shiang [National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu 30076, Taiwan (China); Department of Electrophysics, National Chiao Tung University, Hsinchu 30050, Taiwan (China)

    2016-08-01

    The effect of an APPLE II-type elliptically polarized undulator (EPU) on the beam dynamics were investigated using active and passive methods. To reduce the tune shift and improve the injection efficiency, dynamic multipole errors were compensated using L-shaped iron shims, which resulted in stable top-up operation for a minimum gap. The skew quadrupole error was compensated using a multipole corrector, which was located downstream of the EPU for minimizing betatron coupling, and it ensured the enhancement of the synchrotron radiation brightness. The investigation methods, a numerical simulation algorithm, a multipole error correction method, and the beam-based measurement results are discussed.

  6. Green electron-beam pumped laser arrays based on II-VI nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Zverev, M.M.; Gamov, N.A.; Zdanova, E.V.; Studionov, V.B.; Peregoudov, D.V. [Moscow State Inst. of Radio Engineering, Electronics and Automations, Moscow (Russian Federation); Ivanov, S.V.; Sedova, I.V.; Gronin, S.V.; Sorokin, S.V.; Kop' ev, P.S. [Ioffe Physical Technical Inst., RAS Polytekhnicheskaya, St. Petersburg (Russian Federation); Olikhov, I.M. [Gamma Co. Ltd., SRC Platan, Fryazino (Russian Federation)

    2010-06-15

    Room temperature electron-beam pumped (U = 15-26 keV) green lasers and laser arrays based on multiple quantum well II-VI structures with an extended up to 2 {mu}m waveguide have been studied. The maximum achieved output pulse power is as high as 31 and 630 W per facet from a single 0.24-mm-wide laser element at the cavity length of 0.4 mm and a laser array consisting of 26 elements, respectively. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  7. A low cost matching motion estimation sensor based on the NIOS II microprocessor.

    Science.gov (United States)

    González, Diego; Botella, Guillermo; Meyer-Baese, Uwe; García, Carlos; Sanz, Concepción; Prieto-Matías, Manuel; Tirado, Francisco

    2012-09-27

    This work presents the implementation of a matching-based motion estimation sensor on a Field Programmable Gate Array (FPGA) and NIOS II microprocessor applying a C to Hardware (C2H) acceleration paradigm. The design, which involves several matching algorithms, is mapped using Very Large Scale Integration (VLSI) technology. These algorithms, as well as the hardware implementation, are presented here together with an extensive analysis of the resources needed and the throughput obtained. The developed low-cost system is practical for real-time throughput and reduced power consumption and is useful in robotic applications, such as tracking, navigation using an unmanned vehicle, or as part of a more complex system.

  8. Ni(II) complexes of arginine Schiff-bases and its interaction with DNA

    Energy Technology Data Exchange (ETDEWEB)

    Sallam, S.A., E-mail: shehabsallam@yahoo.com [Chemistry Department, Faculty of Science, Suez Canal University, Isamilia (Egypt); Abbas, A.M. [Chemistry Department, Faculty of Science, Suez Canal University, Isamilia (Egypt)

    2013-04-15

    Ni(II) complexes with Schiff-bases obtained by condensation of arginine with salicylaldehyde; 2,3-; 2,4-; 2,5-dihydroxybenzaldehyde and o-hydroxynaphthaldehyde have been synthesized using the template method in ethanol or ammonia media. They were characterized by elemental analyses, conductivity measurements, magnetic moment, UV, IR and {sup 1}H NMR spectra as well as thermal analysis (TG, DTG and DTA). The Schiff-bases are dibasic tridentate donors and the complexes have diamagnetic square planar and octahedral structures. The complexes decompose in three steps where kinetic and thermodynamic parameters of the decomposition steps were computed. The interactions of the formed complexes with FM-DNA were monitored by UV and fluorescence spectroscopy. -- Highlights: ► Arginine Schiff-bases and their nickel(II) complexes have been synthesized. ► Magnetic and spectral data show diamagnetic square planar and octahedral complexes. ► The complexes thermally decompose in three stages. Interaction with FM-DNA shows hyperchromism with blue shift.

  9. Cellular responses to chlorin-based photosensitizer DH-II-24 under darkness in human gastric adenocarcinoma AGS cells.

    Science.gov (United States)

    Lim, Young-Cheol; Yoo, Je-Ok; Kang, Seong-Sik; Kim, Young-Myeong; Ha, Kwon-Soo

    2011-03-01

    We investigated cellular responses to chlorin-based photosensitizer DH-II-24 under darkness in human gastric adenocarcinoma AGS cells. Cells were loaded with 0.5-10 μg/mL DH-II-24 for 12 h, and intracellular reactive oxygen species (ROS) and intracellular Ca(2+) levels, in situ tissue transglutaminase (tTGase) activity, cell viability, cell morphology and cell cycle were examined. DH-II-24 treatment had no effect on intracellular ROS production or cell morphology, and did not induce cell detachment at any concentrations tested. In addition, cell viability and cell cycle progression were not altered by the photosensitizer. However, DH-II-24 treatment elevated the basal level of intracellular Ca(2+) in a dose-dependent manner and inhibited tTGase activity without affecting tTGase expression levels. Furthermore, DH-II-24 inhibited lysophosphatidic acid-induced activation of tTGase in a dose-dependent manner. In contrast, photodynamic therapy (PDT) with 1 μg/mL DH-II-24 significantly elevated intracellular ROS and in situ tTGase activity in parallel with a rapid and large increase in intracellular Ca(2+) levels. DH-II-24-mediated PDT decreased cell viability and induced cell detachment. These results demonstrate that DH-II-24 treatment alone under darkness induced different cellular responses to DH-II-24-mediated PDT.

  10. Spectroscopic, thermal characterization and cytotoxic activity of bi-, tri- and tetra-nuclear Pd(II) and Pt(II) complexes with diSchiff base ligands

    Science.gov (United States)

    Hegazy, Wael Hussein

    2014-10-01

    In this paper; new di-, tri-, and tetra-nuclear Pd(II) and Pt(II) complexes of N,N‧-bis(3,4-dihydroxybenzylidene)ethan-1,2-diamine (EDH4), N,N‧-bis(3,4-dihydroxy-benzylidene)-benzene-1,2-diamine (PDH4) and N,N‧-bis-(3,4-dihydroxybenzylidene)-4,5-dimethyl-1,2-diamine (MPDH4) ligands were synthesized by two different methods. The first method involve the synthesis of the three ligands from condensation reaction of 3,4-dihydroxybenzaldehyde (L‧H2) with ethylenediamine (en), o-phenylenediamine (o-PD), or 4,5-dimethyl-1,2-phenylendiamine (DMPD) in a mole ratio of 2:1 followed by the reaction of the resulting Schiff bases ligands with Pd(II) or Pt(II) ions in the presence of 2,2‧-dipyridyl (L) to form the di- and tri-nuclear metal complexes. The second method involve the condensation of the Pd complex LPd(II)L‧, (L = 2,2‧-dipyridyl, L‧ = 4-formylbenzene-1,2-bis(olate)) with en, o-PD, or DMPD in a mole ratio of 2:1, respectively, followed by reaction with PdCl2 to form di-, tri-, and tetra-nuclear palladium(II) complexes, respectively. Structures of ligands and metal complexes are characterized by physical properties, FT-IR spectra and nuclear magnetic resonance. The geometries of metal complexes are suggested according to elemental analysis, electronic absorption spectra, thermal analysis, atomic absorption, magnetic susceptibility and molar conductance. Cytotoxic activity against lung large cell carcinoma (H460), prostate carcinoma (DU145), breast adenocarcinoma (MCF-7), amelanotic melanoma (M-14), colon adenocarcinoma (HT-29), and chronic myelogenous leukemia (K562) is also reported.

  11. Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies.

    Science.gov (United States)

    Dhahagani, K; Mathan Kumar, S; Chakkaravarthi, G; Anitha, K; Rajesh, J; Ramu, A; Rajagopal, G

    2014-01-03

    Metal(II) chelates of Schiff bases derived from the condensation of 4-morpholinoaniline with substituted salicylaldehyde have been prepared and characterized by (1)H NMR, IR, electronic, EPR, and magnetic measurement studies. The complexes are of the type M(X-MPMP)2 [where M=Cu(II), Co(II)), Zn(II), or VO(IV); MPMP=2-[(4 morpholinophenyl imino) methyl] 4-X-phenol, X=Cl, (L1H), X=Br (L2H)]. Single crystal X-ray crystallography studies confirm the structure of newly synthesized Schiff bases. The Schiff bases act as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The free ligands and metal complexes are screened for their biopotency. Metal complexes exhibit better activity than ligands. Anticancer activity of ligands and their metal complexes are evaluated in human heptocarcinoma(HepG2) cells. The preliminary bioassay indicates that the Schiff base and its zinc complex exhibit inhibitory activity against the human gastric cancer cell lines.

  12. Synthesis, characterization and thermogravimetric analysis of Co(II, Ni(II, Cu(II and Zn(II complexes supported by ONNO tetradentate Schiff base ligand derived from hydrazino benzoxazine

    Directory of Open Access Journals (Sweden)

    N. Kavitha

    2017-01-01

    Full Text Available A new series of Co(II, Ni(II, Cu(II and Zn(II metal complexes of a novel ligand 3-(2-(1-(2,4-DihydroxyPhenylethylidenehydrazinyl-2H-benzo[b][1,4]oxazin-2-one, (DPE-HBO were prepared and characterized. Microwave synthesis of the ligand was also carried out which gave a high increase in its yield within very short time. 3D molecular modeling structure of the ligand is obtained by using ArgusLab software. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analysis, thermal, infrared, electronic spectra, magnetic moments and conductivity measurements. ESR spectrum of Cu(II complex is studied. All the complexes show subnormal magnetic moments. ONNO donor atoms participate in coordination with Cu(II and Zn(II complexes exhibiting octahedral geometry. Co(II and Ni(II complexes behave differently with ONNO donor atoms showing two types of geometries i.e., octahedral and square planar within the same complex.

  13. Synthesis, Characterization and Antimicrobial Activities of 1,2,4-Triazole /Isatin Schiff bases and their Mn(II, Co(II complexes

    Directory of Open Access Journals (Sweden)

    Sunita Bajroliya

    2014-12-01

    Full Text Available Mn(II and Co(II metal complexes have been synthesized with newly synthesized Schiff bases derived from isatin/5-nitroisatin and 3-substituted-4-amino-5-mercapto-1,2,4-triazole by new environmental benign microwave irradiation method as well as conventional method. Reaction achieved by microwave irradiation technique, require drastically reduced reaction time and provide high yield with improved selectivity as compared to conventional method. The synthesized compounds were characterized by elemental analysis as well as spectral studies. The elemental analysis were clearly indicated that ML2 type complexes have 1:2 stoichiometry (M=metal, L=ligand. The synthesized Schiff bases and their metal complexes screened for antimicrobial activities against selected bacteria and fungi.

  14. Synthetic secondary chromosomes in Escherichia coli based on the replication origin of chromosome II in Vibrio cholerae.

    Science.gov (United States)

    Messerschmidt, Sonja J; Kemter, Franziska S; Schindler, Daniel; Waldminghaus, Torsten

    2015-02-01

    Recent developments in DNA-assembly methods make the synthesis of synthetic chromosomes a reachable goal. However, the redesign of primary chromosomes bears high risks and still requires enormous resources. An alternative approach is the addition of synthetic chromosomes to the cell. The natural secondary chromosome of Vibrio cholerae could potentially serve as template for a synthetic secondary chromosome in Escherichia coli. To test this assumption we constructed a replicon named synVicII based on the replication module of V. cholerae chromosome II (oriII). A new assay for the assessment of replicon stability was developed based on flow-cytometric analysis of unstable GFP variants. Application of this assay to cells carrying synVicII revealed an improved stability compared to a secondary replicon based on E. coli oriC. Cell cycle analysis and determination of cellular copy numbers of synVicII indicate that replication timing of the synthetic replicon in E. coli is comparable to the natural chromosome II (ChrII) in V. cholerae. The presented synthetic biology work provides the basis to use secondary chromosomes in E. coli to answer basic research questions as well as for several biotechnological applications.

  15. Preparation and Electronic Property Investigation of Zinc(II-Schiff Base Complexes in the Confined Space

    Directory of Open Access Journals (Sweden)

    Peng Shang

    2013-01-01

    Full Text Available Metal-Schiff base complexes have attracted continued research interest regarding their intriguing and useful features, while the electronic properties of these complexes in the confined space have not been sufficiently addressed in previous studies. In this work, a new zinc(II-Schiff base complex bis(N-dodecyl salicylideneiminatoZn(II (1 was synthesized and subsequently loaded in an inorganic solid host. A large red shift (~40 nm of the absorption onset was recorded, when the microenvironment of 1 changed from the solvent ethanol to the inorganic solid medium, evidencing the confined space effect. The marked shift of the absorption onset was associated with a band-gap reduction between the highest occupied molecular orbital (HOMO and the lowest unoccupied molecular orbital (LUMO. Theoretical calculation results showed that the confined space effect is distance dependent and exerts a more profound influence on the HOMO than the LUMO within an effective distance range. An initial study implied that the confined space effect is also accompanied with the electron density variation.

  16. Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II, Cu(II, Ni(II, and Zn(II Complexes with Amino Acid-Derived Compounds

    Directory of Open Access Journals (Sweden)

    Zahid H. Chohan

    2006-01-01

    Full Text Available A series of antibacterial and antifungal amino acid-derived compounds and their cobalt(II, copper(II, nickel(II, and zinc(II metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments, and IR, and electronic spectral measurements. Ligands (L1–(L5 were derived by condensation of β-diketones with glycine, phenylalanine, valine, and histidine and act as bidentate towards metal ions (cobalt, copper, nickel, and zinc via the azomethine-N and deprotonated-O of the respective amino acid. The stoichiometric reaction between the metal(II ion and synthesized ligands in molar ratio of M: L (1: 1 resulted in the formation of the metal complexes of type [M(L(H2O4]Cl (where M = Co(II, Cu(II, and Zn(II and of M: L (1: 2 of type [M(L2(H2O2] (where M = Co(II, Cu(II, Ni(II, and Zn(II. The magnetic moment data suggested for the complexes to have an octahedral geometry around the central metal atom. The electronic spectral data also supported the same octahedral geometry of the complexes. Elemental analyses and NMR spectral data of the ligands and their metal(II complexes agree with their proposed structures. The synthesized ligands, along with their metal(II complexes, were screened for their in vitro antibacterial activity against four Gram-negative (Escherichia coli, Shigella flexeneri, Pseudomonas aeruginosa, and Salmonella typhi and two Gram-positive (Bacillus subtilis and Staphylococcus aureus bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glaberata. The results of these studies show the metal(II complexes to be more antibacterial/antifungal against one or more species as compared to the uncomplexed ligands. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties. Five compounds, (3, (7, (10, (11, and (22, displayed potent cytotoxic

  17. Two interpenetrating Cu{sup II}/Ni{sup II}-coordinated polymers based on an unsymmetrical bifunctional N/O-tectonic: Syntheses, structures and magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yong-Liang [College of Materials & Chemical Engineering, China Three Gorges University, Yichang 443002 (China); Department of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources, Shang Luo University, Shang Luo 726000 (China); Wu, Ya-Pan [College of Materials & Chemical Engineering, China Three Gorges University, Yichang 443002 (China); Li, Dong-Sheng, E-mail: lidongsheng1@126.com [College of Materials & Chemical Engineering, China Three Gorges University, Yichang 443002 (China); Dong, Wen-Wen [College of Materials & Chemical Engineering, China Three Gorges University, Yichang 443002 (China); Zhou, Chun-Sheng [Department of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources, Shang Luo University, Shang Luo 726000 (China)

    2015-03-15

    Two new interpenetrating Cu{sup II}/Ni{sup II} coordination polymers, based on a unsymmetrical bifunctional N/O-tectonic 3-(pyrid-4′-yl)-5-(4″-carbonylphenyl)-1,2,4-triazolyl (H{sub 2}pycz), ([Cu-(Hpycz){sub 2}]·2H{sub 2}O){sub n} (1) and ([Ni(Hpycz){sub 2}]·H{sub 2}O){sub n} (2), have been solvothermally synthesized and structure characterization. Single crystal X-ray analysis indicates that compound 1 shows 2-fold parallel interpenetrated 4{sup 4}-sql layers with the same handedness. The overall structure of 1 is achiral—in each layer of doubly interpenetrating nets, the two individual nets have the opposite handedness to the corresponding nets in the adjoining layers—while 2 features a rare 8-fold interpenetrating 6{sup 6}-dia network that belongs to class IIIa interpenetration. In addition, compounds 1 and 2 both show similar paramagnetic characteristic properties. - Graphical abstract: Two new Cu(II)/Ni(II) coordination polymers present 2D parallel 2-fold interpenetrated 4{sup 4}-sql layers and a rare 3D 8-fold interpenetrating 6{sup 6}-dia network. In addition, magnetic susceptibility measurements show similar paramagnetic characteristic for two complexes. - Highlights: • A new unsymmetrical bifunctional N/O-tectonic as 4-connected spacer. • A 2-fold parallel interpenetrated sql layer with the same handedness. • A rare 8-fold interpenetrating dia network (class IIIa)

  18. Structural analysis and physico-chemical characterization of mononuclear manganese(II) and polynuclear copper(II) complexes with pyridine-based alcohol

    Science.gov (United States)

    Zienkiewicz-Machnik, Małgorzata; Masternak, Joanna; Kazimierczuk, Katarzyna; Barszcz, Barbara

    2016-12-01

    Two novel manganese(II) and copper(II) complexes, mononuclear [Mn(H2O)2(2-(CH2)2OHpy)2](NO3)2 (1) and polynuclear [Cu(SO4)(2-(CH2)2OHpy)2]n (2), based on 2-(hydroxyethyl)pyridine (2-(CH2)2OHpy) were synthesised and fully characterised using X-ray structure analysis as well as spectroscopic, magnetic and thermal methods. Both central metal ions Mn(1) and Cu(1) are coordinated by two N,O-donor 2-(CH2)2OHpy ligands and possess an almost perfect octahedral geometry (a chromophore of {MN2O4} type). The coordination sphere of Mn(II) is completed by two molecules of water, whereas, in polynuclear complex 2, Cu(II) atoms are linked along the a crystallographic direction by bridging sulfate ligands in a μ2-κ2 binding mode to form chains. The intermolecular interactions in 1 and 2 have been interpreted in view of the 3D Hirshfeld surface analysis and associated 2D fingerprint plots. Furthermore, the complexes have been tested with ABTSrad + assay in order to assess their antioxidant activity. In addition, the IC50 values calculated for 1 and 2 revealed that the complexes show a higher antioxidant activity than corresponding ligand.

  19. 76 FR 12611 - Risk-Based Capital Standards: Advanced Capital Adequacy Framework-Basel II; Establishment of a...

    Science.gov (United States)

    2011-03-08

    ... Office of Thrift Supervision 12 CFR Part 567 RIN 1550-AC41 Risk-Based Capital Standards: Advanced Capital Adequacy Framework--Basel II; Establishment of a Risk-Based Capital Floor AGENCY: Office of Thrift...) proposes to: Amend its advanced risk-based capital adequacy standards (advanced approaches rules) \\1\\ to...

  20. Synthesis, Characterization and Antibacterial Activity of Novel Schiff Bases Derived from 4-Phenyl-2-aminothiazole and their Mn(II, Fe(II, Co(II, Ni(II and Cu(II Metal complexes

    Directory of Open Access Journals (Sweden)

    A. S. Thakar

    2011-01-01

    Full Text Available Novel Schiff bases and their metal complexes were derived from some hetero cyclic β-diketones with 4-phenyl-2-aminothiazole. All the synthesized compounds were confirmed their structure by Elemental analysis, FT-IR, 1H NMR, 13C NMR, Mass spectra, TGA analysis and UV spectra. All the compounds were tested for their antibacterial activity. Spectroscopic measurements suggest that all Schiff base metal complexes are of type ML2.(H2O2 (M=Mn, Fe, Co, Ni and Cu and all the metal complexes shows moderate antibacterial activity in the agar cup assay method.

  1. Cobalt(II), Nickel(II) and Copper(II) complexes of a tetradentate Schiff base as photosensitizers: Quantum yield of 1O2 generation and its promising role in anti-tumor activity

    Science.gov (United States)

    Pradeepa, S. M.; Bhojya Naik, H. S.; Vinay Kumar, B.; Indira Priyadarsini, K.; Barik, Atanu; Ravikumar Naik, T. R.

    2013-01-01

    In the present investigation, a Schiff base N'1,N'3-bis[(E)-(5-bromo-2-hydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide and its metal complexes have been synthesized and characterized. The DNA-binding studies were performed using absorption spectroscopy, emission spectra, viscosity measurements and thermal denatuaration studies. The experimental evidence indicated that, the Co(II), Ni(II) and Cu(II) complexes interact with calf thymus DNA through intercalation with an intrinsic binding constant Kb of 2.6 × 104 M-1, 5.7 × 104 M-1 and 4.5 × 104 M-1, respectively and they exhibited potent photodamage abilities on pUC19 DNA, through singlet oxygen generation with quantum yields of 0.32, 0.27 and 0.30 respectively. The cytotoxic activity of the complexes resulted that they act as a potent photosensitizers for photochemical reactions.

  2. Cobalt(II), Nickel(II) and Copper(II) complexes of a tetradentate Schiff base as photosensitizers: Quantum yield of 1O2 generation and its promising role in anti-tumor activity.

    Science.gov (United States)

    Pradeepa, S M; Bhojya Naik, H S; Vinay Kumar, B; Indira Priyadarsini, K; Barik, Atanu; Ravikumar Naik, T R

    2013-01-15

    In the present investigation, a Schiff base N'1,N'3-bis[(E)-(5-bromo-2-hydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide and its metal complexes have been synthesized and characterized. The DNA-binding studies were performed using absorption spectroscopy, emission spectra, viscosity measurements and thermal denatuaration studies. The experimental evidence indicated that, the Co(II), Ni(II) and Cu(II) complexes interact with calf thymus DNA through intercalation with an intrinsic binding constant Kb of 2.6×10(4) M(-1), 5.7×10(4) M(-1) and 4.5×10(4) M(-1), respectively and they exhibited potent photodamage abilities on pUC19 DNA, through singlet oxygen generation with quantum yields of 0.32, 0.27 and 0.30 respectively. The cytotoxic activity of the complexes resulted that they act as a potent photosensitizers for photochemical reactions.

  3. Development of mercury (II) ion biosensors based on mercury-specific oligonucleotide probes.

    Science.gov (United States)

    Li, Lanying; Wen, Yanli; Xu, Li; Xu, Qin; Song, Shiping; Zuo, Xiaolei; Yan, Juan; Zhang, Weijia; Liu, Gang

    2016-01-15

    Mercury (II) ion (Hg(2+)) contamination can be accumulated along the food chain and cause serious threat to the public health. Plenty of research effort thus has been devoted to the development of fast, sensitive and selective biosensors for monitoring Hg(2+). Thymine was demonstrated to specifically combine with Hg(2+) and form a thymine-Hg(2+)-thymine (T-Hg(2+)-T) structure, with binding constant even higher than T-A Watson-Crick pair in DNA duplex. Recently, various novel Hg(2+) biosensors have been developed based on T-rich Mercury-Specific Oligonucleotide (MSO) probes, and exhibited advanced selectivity and excellent sensitivity for Hg(2+) detection. In this review, we explained recent development of MSO-based Hg(2+) biosensors mainly in 3 groups: fluorescent biosensors, colorimetric biosensors and electrochemical biosensors.

  4. FPGA based data reduction algorithm for the Belle-II DEPFET detector

    Energy Technology Data Exchange (ETDEWEB)

    Muenchow, David; Fleischer, Soeren; Gessler, Thomas; Kuehn, Wolfgang; Lange, Jens-Soeren; Spruck, Bjoern [II. Physikalisches Institut, Universitaet Giessen (Germany); Collaboration: Belle-II PXD Collaboration

    2012-07-01

    The readout system of the pixel detector (PXD) at the future Belle-II experiment will have to cope with an estimated input data rate of {<=}21.6 GB/s. The hardware platform of the readout system is going to be ATCA-based Compute Node (CN) with Xilinx Virtex-5 FX70T FPGAs. The large data rate must be reduced by a factor {proportional_to}10 before being send to the event builder. The reduction is done by a region-of-interest (ROI) algorithm based upon e.g. track finding on the high level trigger (HLT). The free/occupied buffer management, ROI selection, and data unpacking algorithms, programmed in VHDL for the FPGAs, will be explained in detail. Performance results for 100/200 MHz clocks and 32/64 bit bus width are presented.

  5. [Digitalization, archival storage and use of image documentation in the GastroBase-II system].

    Science.gov (United States)

    Kocna, P

    1997-05-14

    "GastroBase-II" is a module of the clinical information system "KIS-ComSyD"; The main part is represented by structured data-text with an expert system including on-line image digitalization in gastroenterology (incl. endoscopic, X-ray and endosonography pictures). The hardware and software of the GastroBase are described as well as six-years experiences with application of digitalized image data. An integration of a picture into text, reports, slides for a lecture or an electronic atlas is documented with examples. Briefly are reported out experiences with graphic editors (PhotoStyler), text editor (WordPerfect) and slide preparation for lecturing with the presentation software PowerPoint. The multimedia applications on the CD-ROM illustrate a modern trend using digitalized image documentation for pregradual and postgradual education.

  6. Ruthenium(II) complexes containing bidentate Schiff bases and triphenylphosphine or triphenylarsine

    Indian Academy of Sciences (India)

    P Viswanathamurthi; R Karvembu; V Tharaneeswaran; K Natarajan

    2005-05-01

    Reactions of ruthenium(II) complexes [RuHX(CO)(EPh3)2(B)] (X = H or Cl; B = EPh3, pyridine (py) or piperidine (pip); E = P or As) with bidentate Schiff base ligands derived by condensing - hydroxyacetophenone with aniline, - or -methylaniline have been carried out. The products were characterized by analytical, IR, electronic and 1H-NMR spectral studies and are formulated as [Ru(X)(CO) (L)(EPh3)(B)] (L = Schiff base anion; X = H or Cl; B = EPh3, py or pip; E = P or As). An octahedral structure has been tentatively proposed for the new complexes. The new complexes were tested for their catalytic activities in the oxidation of benzyl alcohol to benzaldehyde.

  7. Synthesis and characterization of cobalt(II), nickel(II), copper(II) and zinc(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine.

    Science.gov (United States)

    Singh, Kiran; Barwa, Manjeet Singh; Tyagi, Parikshit

    2007-03-01

    A few (1:1) and (1:2) metal complexes of cobalt(II), nickel(II), copper(II) and zinc(II) have been isolated with ligand derived from the condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 2-acetylpyridine (L(1)) and characterized by elemental analysis, conductivity measurements, infrared, electronic, (1)H NMR spectral data, magnetic and thermogravimetric analyses. Due to insolubility in water and most of the common organic solvents and infusibility at higher temperatures, all the complexes are thought to be polymeric in nature. A square-planar geometry was suggested for copper(II) and octahedral proposed for cobalt(II), nickel(II) and zinc(II). Some of the chemically synthesized compounds have been screened in vitro against the three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) and two Gram-negative (Salmonella typhi and Escherichia coli) organisms. It is observed that the coordination of metal ion has pronounced effect on the microbial activities of the ligand. The metal complexes have higher antimicrobial effect than the free ligands.

  8. Synthesis and characterization of polymeric azido Zn(II) and Ni(II) complexes based on 3-hydroxypyridine

    Science.gov (United States)

    Mautner, Franz A.; Berger, Christian; Domian, Elisabeth; Fischer, Roland C.; Massoud, Salah S.

    2016-10-01

    The synthesis and structural characterization of two new complexes catena-[Ni(3-O-py)(3-HO-py)2(μ1,3-N3)(H2O)] (1) and catena-[Zn(μ-3-O-py)(μ1,1-N3)] (2), where 3-HO-py = 3-hydroxypyridine, are reported. The complexes were characterized by the elemental microanalyses, IR, and X-ray crystallography and by UV-Vis spectroscopy for complex 1. Single crystal X-ray crystallography revealed the polymeric nature of the complexes: 1 as 1D with a single EE azide bridging, and 2 as 2D with μ(O,O‧,N) bridging of the deprotonated 3-O-py anions and di-EO azide groups, respectively. In 1 the neutral and deprotonated 3-hydroxypyridine molecules act only as N-terminal ligands. The emission spectral properties of the Zn(II) complex were investigated.

  9. Simultaneous trace-levels determination of Hg(II) and Pb(II) ions in various samples using a modified carbon paste electrode based on multi-walled carbon nanotubes and a new synthesized Schiff base

    Energy Technology Data Exchange (ETDEWEB)

    Afkhami, Abbas, E-mail: afkhami@basu.ac.ir [Faculty of Chemistry, Bu-Ali Sina University, Hamedan (Iran, Islamic Republic of); Bagheri, Hasan [Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan (Iran, Islamic Republic of); Khoshsafar, Hosein [Faculty of Chemistry, Bu-Ali Sina University, Hamedan (Iran, Islamic Republic of); Saber-Tehrani, Mohammad [Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Tabatabaee, Masoumeh [Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd (Iran, Islamic Republic of); Shirzadmehr, Ali [Faculty of Chemistry, Bu-Ali Sina University, Hamedan (Iran, Islamic Republic of)

    2012-10-09

    Highlights: Black-Right-Pointing-Pointer A new chemically modified carbon paste electrode was constructed and used. Black-Right-Pointing-Pointer A new Schiff base and multi-walled carbon nanotube was used as a modifier. Black-Right-Pointing-Pointer The electrochemical properties of the modified electrode were studied. Black-Right-Pointing-Pointer The electrode was used to the simultaneous determination of Pb{sup 2+} and Hg{sup 2+}. - Abstract: A modified carbon paste electrode based on multi-walled carbon nanotubes (MWCNTs) and 3-(4-methoxybenzylideneamino)-2-thioxothiazolodin-4-one as a new synthesized Schiff base was constructed for the simultaneous determination of trace amounts of Hg(II) and Pb(II) by square wave anodic stripping voltammetry. The modified electrode showed an excellent selectivity and stability for Hg(II) and Pb(II) determinations and for accelerated electron transfer between the electrode and the analytes. The electrochemical properties and applications of the modified electrode were studied. Operational parameters such as pH, deposition potential and deposition time were optimized for the purpose of determination of traces of metal ions at pH 3.0. Under optimal conditions the limits of detection, based on three times the background noise, were 9.0 Multiplication-Sign 10{sup -4} and 6.0 Multiplication-Sign 10{sup -4} {mu}mol L{sup -1} for Hg(II) and Pb(II) with a 90 s preconcentration, respectively. In addition, the modified electrode displayed a good reproducibility and selectivity, making it suitable for the simultaneous determination of Hg(II) and Pb(II) in real samples such as sea water, waste water, tobacco, marine and human teeth samples.

  10. A risk-adapted strategy of radiotherapy or cisplatin-based chemotherapy in stage II seminoma.

    Science.gov (United States)

    Domont, Julien; Massard, Christophe; Patrikidou, Anna; Bossi, Alberto; de Crevoisier, Renaud; Rose, Mathieu; Wibault, Pierre; Fizazi, Karim

    2013-07-01

    Indications for radiotherapy and chemotherapy in stage II seminoma are currently debated. Since 1980, the policy at Institut Gustave Roussy was to treat patients with stage IIA-B disease with external radiotherapy and patients with stage IIB-C with cisplatin-based chemotherapy. In stage IIB disease, 3 cm was the usual tumor size threshold above which individual patients were considered for chemotherapy. During the period 1980-2001, 67 patients with stage II seminoma were treated: stage IIA (n = 5), stage IIB (n = 31), and stage IIC (n = 31). The median age was 40 years (range: 23-64). Among 37 patients who received radiotherapy, 5, 28, and 4 had a stage IIA, IIB, and IIC, respectively. Among 30 patients who received chemotherapy, 27 had a stage IIC. With a median follow-up of 9.4 years, 19 relapses (28%) occurred, including 11 and 8 cases treated with radiotherapy (30%) and chemotherapy (27%), respectively. The 5-year relapse-free survival was 71% (95% CI: 59-80). All but three relapses were salvaged with chemotherapy followed in selected cases by surgical resection of residual masses. Only 3 patients died of seminoma. The 5-year overall survival rate is 97% (95% CI: 89-99). Five patients subsequently developed a non-germ-cell second cancer, which occurred within the radiation field in 3 cases. With an overall survival rate of 97%, the overall outcome of patients with stage II seminoma managed according to this risk-adapted strategy is good. The possibility of extending the indications for chemotherapy to selected stage IIB seminoma patients needs to be further evaluated as potentially beneficial in terms of relapse risk. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. Experimental implementation of edge nodes for an OPS system based on Nios II

    Science.gov (United States)

    Li, Xiaoyun; Xu, Bo; Qiu, Kun; Zhou, Heng

    2008-12-01

    The advantages of Optical Packet Switching (OPS) are transparent data transmission and data format, flexible packet control and dynamic resource allocation. It thus can support high-speed transmission of wideband data networks. Unlike Optical Burst Switching (OBS) systems which need reserved channel to transmit destination address, an advanced OPS solution using Optical Orthogonal Code (OOC) label for payload transfer has been proposed in this paper. Different from other OPS systems, our edge nodes are required to realize some special tasks including extracting destination addresses of the received IP packet which is used as payload in our OPS systems and sending the addresses to the OOC label generator. The OOC label will later be used to identify the destination of each payload at the core node for optical switching. Meanwhile, the higher-priority flow can be prior-serviced according to the Type of Service (TOS) in the head of IP packet. It is experimentally shown that the edge nodes in this OPS system can effectively improve the efficiency of packet switching and the speed of data transmission. The edge node implementation contains two parts: the hardware and software. For the hardware part, all necessary modules have been integrated onto one PCB board, thus avoiding possible instability caused by interconnecting different modules like transmitting/receiving Ethernet frame module, Field Programmable Gate Array (FPGA) processing module and optical transceiver module etc. from different Printed Circuit Boards (PCB). For the software part, the whole of system was based on MicroC/OS-II operating systems running on the Nios II soft core processor. It is verified by the experiment that embedded system designed with Nios II soft core CPU can help to speed up the hardware design. With the SOPC Builder's development environment, more attention can be paid to the structure and function of the system without worrying about the details of the circuit design, and better

  12. In vitro DNA binding profile of enantiomeric dinuclear Cu(II)/Ni(II) complexes derived from l-/d-histidine-terepthaldehyde reduced Schiff base as potential chemotherapeutic agents.

    Science.gov (United States)

    Yousuf, Imtiyaz; Arjmand, Farukh

    2016-11-01

    New chiral reduced Schiff base ligands, L1 and L2 derived from l-/d-histidine and terepthaldehyde, and their Cu(II) and Ni(II) dinuclear complexes 1 &2 (a and b) were synthesized and thoroughly characterized by various spectroscopic techniques. Comparative binding profile of both l-/d-enantiomeric Cu(II) and Ni(II) complexes with ct-DNA was studied by employing optical and spectroscopic techniques to evaluate their enantiopreferential selectivity towards molecular target DNA and thereby explore their relative chemotherapeutic potential. Quantitative assessment of DNA binding propensity was ascertained by calculating Kb, K and Ksv values of 1 &2 (a and b) which demonstrated higher binding affinity of l-enantiomeric Cu(II) complex, 1a and followed the order as 1a>1b>2a>2b. Scanning electron microscopy (SEM) was used to analyze the morphological changes of the DNA condensate in presence of complexes 1 (a and b). The SEM micrographs condensates revealed morphological transitions and formation of different structural features implicating the condensation process between the complexes and biomolecule occurred to form compact massive structures. The gel electrophoretic assay of complex 1a was carried out with pBR322 plasmid DNA which revealed an efficient cleaving ability of the complex via oxidative pathway with the involvement of singlet oxygen ((1)O2) and the superoxide anion (O2(•-)) radicals as the ROS responsible the cleavage reactions. Molecular docking studies of 1 (a and b) with DNA revealed selective recognition of G-C residues of the narrow minor groove of the DNA duplex and complex 1a demonstrated binding affinity towards DNA ascertained from its higher binding energy values. Furthermore, the cytotoxic assessment of 1a was examined on a panel of cancer cell lines of different histological origin employing SRB assay which revealed remarkably good cytotoxic activity towards HL60, HeLa and MCF7 cancer cell lines.

  13. Isotherm and thermodynamic studies of Zn (II) adsorption on lignite and coconut shell-based activated carbon fiber.

    Science.gov (United States)

    Shrestha, Sohan; Son, Guntae; Lee, Seung Hwan; Lee, Tae Gwan

    2013-08-01

    The Zn (II) adsorption capacity of lignite and coconut shell-based activated carbon fiber (ACF) was evaluated as a function of initial Zn (II) concentration, temperature and contact time in batch adsorption process in this study. Adsorption uptake increased with initial Zn (II) concentration and temperature. Optimal contact time for the adsorption of Zn (II) ions onto lignite and coconut shell-based ACF was found to be 50 min. Removal percentage decreased from 88.0% to 78.54% with the increment in initial Zn (II) concentration from 5 to 50 mg L(-1). Equilibrium data fit well with Langmuir-I isotherm indicating homogeneous monolayer coverage of Zn (II) ions on the adsorbent surface. Maximum monolayer adsorption capacity of Zn (II) ions on ACF was found to be 9.43 mg g(-1). Surface morphology and functionality of ACF prior to and after adsorption were characterized by electron microscopy and infrared spectroscopy. Various thermodynamic parameters such as standard Gibbs free energy (ΔG°), standard enthalpy (ΔH°), and standard entropy (ΔS°) were evaluated.

  14. Synthesis and Antibacterial Activities of Sulfur-Containing Bissalicylaldehyde Schiff Base and Binuclear Nickel(II Nanorod Complex

    Directory of Open Access Journals (Sweden)

    Xiao-Lan Yang

    2013-01-01

    Full Text Available Nickel(II acetate tetrahydrate was treated with the ligand CH2(H2sal-sbdt2 in methanol heated at reflux to yield a novel binuclear Ni(II nanorod complex of the formula CH2{Ni(II(sal-sbdt(H2O}2. The ligand of CH2(H2sal-sbdt2 was derived from 5,5′-methylene-bissalicylaldehyde and S-benzyldithiocarbazate. The complex was characterized by elemental analysis, UV-Vis, FT-IR spectra, thermal analysis (TG-DSC, and scanning electron microscopy (SEM. The nickel(II was coordinated by imino nitrogen, thiolato sulfur, and phenolic oxygen from the Schiff base ligand, and oxygen from the coordinated water, respectively. The pyrolysis reactions in the thermal decomposition process of the complex, the experimental, and calculated percentage mass loss were also given. The Ni(II complex belonged to nanocrystalline metal complex, and the average size of the nanorod complex was about 30 nm × 150 nm. The antibacterial activities were screened for the Schiff base ligand and the Ni(II nanorod complex against four bacteria: Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Staphylococcus epidermidis. Both the ligand of CH2(H2sal-sbdt2 and the Ni(II complex had the most intense antibacterial activities against Escherichia coli.

  15. Synthesis, characterization, biological activity and DNA cleavage studies of tridentate Schiff bases and their Co(II complexes

    Directory of Open Access Journals (Sweden)

    P. Kavitha

    2016-01-01

    Full Text Available In the present study a series of Co(II complexes of formyl chromone Schiff bases have been synthesized characterized by analytical, molar conductance, IR, electronic, magnetic susceptibility, thermal, fluorescence and powder XRD measurements and screened for various biological activities (antimicrobial, antioxidant, nematicidal, DNA cleavage and cytotoxicity. In all the Co(II complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non-electrolytic in nature. Based on the electronic and magnetic data, an octahedral geometry is ascribed for all the Co(II complexes. Thermal behaviour of the synthesized complexes illustrates the general decomposition patterns of the complexes. The X-ray analysis data show that all the Co(II complexes have triclinic crystal system with different unit cell parameters. Metal complexes have greater antimicrobial activity than ligands. Antioxidant and nematicidal activities indicate that the ligands exhibit greater activity when compared to their respective Co(II complexes. All ligands and Co(II complexes of HL1 and HL2 showed considerable anticancer activity against Raw, MCF-7 and COLO 205 cell lines. All ligands and their Co(II complexes showed more pronounced DNA cleavage activity in the presence of H2O2.

  16. Copper(II)-selective membrane electrode based on a recently synthesized naphthol-derivative Schiff's base

    Energy Technology Data Exchange (ETDEWEB)

    Alizadeh, N.; Ershad, S. [Dept. of Chemistry, Tarbiat Moderres Univ., Tehran (Iran); Naeimi, H.; Sharghi, H. [Dept. of Chemistry, Shiraz Univ. (Iran); Shamsipur, M. [Dept. of Chemistry, Razi Univ., Kermanshah (Iran)

    1999-11-01

    A PVC membrane electrode for copper(II) ions based on a recently synthesized naphthol-derivative Schiff's base as membrane carrier was prepared. The sensor exhibits a Nernstian response for Cu{sup 2+} ions over a wide concentration range (5.0 x 10{sup -6}-5.0 x 10{sup -2} mol/L) with a detection limit of 3.1 x 10{sup -6} mol/L (0.2 {mu}g/mL). It has a very short response time of about 5 s and can be used for 3 months without any divergence in potential. The proposed electrode revealed good selectivities over a wide variety of other cations including alkali, alkaline earth, transition and heavy metal ions and could be used in a pH range of 4.0-7.0. It was successfully applied to the direct determination and potentiometric titration of copper ion. (orig.)

  17. Crystal bases and quiver varieties (Geometric construction of crystal bases II)

    OpenAIRE

    Saito, Yoshihisa

    2001-01-01

    We give a crystal structure on the set of all irreducible components of Lagrangian subvarieties of quiver varieties. One con show that, as a crystal, it is isomorphic to the crystal base of an irreducible highest weight representation of a quantized universal enveloping algebra.

  18. Impact of patient-based teaching in improving prescription writing skills of II MBBS students.

    Science.gov (United States)

    Thenrajan, Padmavathi; Murugan, P Rajavel

    2016-01-01

    Although prescription writing is a part of the medical students' curriculum, their prescribing skills are still poor either as a part of their examinations or as they go out as qualified health professionals which may be due to inadequate training. Educational intervention like patient-based teaching in pharmacology offers lifelike preparation and provides more relevance, easier recall, and help in improving prescribing skills. This study aims to determine the role of patient-based teaching in improving the prescribing skill of II year medical students compared to conventional case-based teaching. This prospective, comparative study was carried out after giving orientation to prescription writing as per the WHO prescribing guidelines (N = 50). The 25 students in control group were given case-based teaching and 25 students in test group were given patient-based teaching of prescription writing for the same five common clinical conditions. The prescription writing skill (knows how level) was assessed by evaluating the prescriptions written in the prescribed format and scored by a 14-point scoring system. The mean scores obtained by the control (9.6) and test (12.04) groups were compared by unpaired Student's t-test (P writing enables students to develop prescribing skills in a complete and professional way.

  19. COMDES-II: A Component-Based Framework for Generative Development of Distributed Real-Time Control Systems

    DEFF Research Database (Denmark)

    Ke, Xu; Sierszecki, Krzysztof; Angelov, Christo K.

    2007-01-01

    The paper presents a generative development methodology and component models of COMDES-II, a component-based software framework for distributed embedded control systems with real-time constraints. The adopted methodology allows for rapid modeling and validation of control software at a higher lev...... methodology for COMDES-II from a general perspective, describes the component models in details and demonstrates their application through a DC-Motor control system case study....

  20. Platinum(II)-Based Metallo-Supramolecular Polymer with Controlled Unidirectional Dipoles for Tunable Rectification.

    Science.gov (United States)

    Chakraborty, Chanchal; Pandey, Rakesh K; Hossain, Md Delwar; Futera, Zdenek; Moriyama, Satoshi; Higuchi, Masayoshi

    2015-09-01

    A platinum(II)-based, luminescent, metallo-supramolecular polymer (PolyPtL1) having an inherent dipole moment was synthesized via complexation of Pt(II) ions with an asymmetric ligand L1, containing terpyridyl and pyridyl moieties. The synthesized ligand and polymer were well characterized by various NMR techniques, optical spectroscopy, and cyclic voltammetry studies. The morphological study by atomic force microscopy revealed the individual and assembled polymer chains of 1-4 nm height. The polymer was specifically attached on Au-electrodes to produce two types of film (films 1 and 2) in which the polymer chains were aligned with their dipoles in opposite directions. The Au-surface bounded films were characterized by UV-vis, Raman spectroscopy, cyclic voltammetry, and atomic force microscopy study. The quantum mechanical calculation determined the average dipole moment for each monomer unit in PolyPtL1 to be about 5.8 D. The precise surface derivatization permitted effective tuning of the direction dipole moment, as well as the direction of rectification of the resulting polymer-attached molecular diodes. Film 1 was more conductive in positive bias region with an average rectification ratio (RR = I(+4 V)/I(-4 V)) ≈ 20, whereas film 2 was more conducting in negative bias with an average rectification ratio (RR = I(-4 V)/I(+4 V)) ≈ 18.

  1. SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes

    Directory of Open Access Journals (Sweden)

    Atul Kumar

    2017-06-01

    Full Text Available Type II diabetes is a chronic condition that affects the way our body metabolizes sugar. The body's important source of fuel is now becoming a chronic disease all over the world. It is now very necessary to identify the new potential targets for the drugs which not only control the disease but also can treat it. Support vector machines are the classifier which has a potential to make a classification of the discriminatory genes and non-discriminatory genes. SVMRFE a modification of SVM ranks the genes based on their discriminatory power and eliminate the genes which are not involved in causing the disease. A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target.

  2. Detection of herbicide subclasses by an optical multibiosensor based on an array of photosystem II mutants.

    Science.gov (United States)

    Giardi, Maria Teresa; Guzzella, Licia; Euzet, Pierre; Rouillon, Regis; Esposito, Dania

    2005-07-15

    Massive use of herbicides in agriculture over the last few decades has become a serious environmental problem. The residual concentration of these compounds frequently exceeds the maximum admissible concentration in drinking water for human consumption and is a real environmental risk for the aquatic ecosystem. Herbicides inhibiting photosynthesis via targeting photosystem II function still represent the basic means of weed control. A multibiosensor was constructed for detecting herbicides using as biosensing elements photosynthetic preparations coupled to an optical fluorescence transduction system (Giardi et al. EU patent EP1134585, 01830148.1-2204); this paper is about its application in the detection of herbicide subclasses in river water. Photosynthetic material was immobilized on a silicio septum inside a series of flow cells, close to diodes so as to activate photosystem II (PSII) fluorescence. The principle of the detection was based on the factthat herbicides selectively modify PSII fluorescence activity. The multibiosensor has the original feature of being able to distinguish the subclasses of the photosynthetic herbicides by using specific immobilized biomediators isolated from mutated organisms. This setup resulted in a reusable, portable multibiosensor for the detection of herbicide subclasses with a half-life of 54 h for spinach thylakoids and limit of detection of 3 x 10(-9) M for herbicides present in river water.

  3. Beam size and position measurement based on logarithm processing algorithm in HLS II

    CERN Document Server

    Cheng, Chaocai; Yang, Yongliang; Zhou, Zeran; Lu, Ping; Wu, Fangfang; Wang, Jigang; Tang, Kai; Luo, Qing; Li, Hao; Zheng, Jiajun; Duan, Qingming

    2015-01-01

    A logarithm processing algorithm to measure beam transverse size and position is proposed and preliminary experimental results in Hefei Light Source II (HLS II) are given. The algorithm is based on only 4 successive channels of 16 anode channels of multianode photomultiplier tube (MAPMT) R5900U-00-L16 which has typical rise time of 0.6 ns and effective area of 0.8x16 mm for a single anode channel. In the paper, we firstly elaborate the simulation results of the algorithm with and without channel inconsistency. Then we calibrate the channel inconsistency and verify the algorithm using general current signal processor Libera Photon in low-speed scheme. Finally we get turn-by-turn beam size and position and calculate the vertical tune in high-speed scheme. The experimental results show that measured values fit well with simulation results after channel differences are calibrated and the fractional part of the tune in vertical direction is 0.3628 which is very close to the nominal value 0.3621.

  4. Fuzzy ranking based non-dominated sorting genetic algorithm-II for network overload alleviation

    Directory of Open Access Journals (Sweden)

    Pandiarajan K.

    2014-09-01

    Full Text Available This paper presents an effective method of network overload management in power systems. The three competing objectives 1 generation cost 2 transmission line overload and 3 real power loss are optimized to provide pareto-optimal solutions. A fuzzy ranking based non-dominated sorting genetic algorithm-II (NSGA-II is used to solve this complex nonlinear optimization problem. The minimization of competing objectives is done by generation rescheduling. Fuzzy ranking method is employed to extract the best compromise solution out of the available non-dominated solutions depending upon its highest rank. N-1 contingency analysis is carried out to identify the most severe lines and those lines are selected for outage. The effectiveness of the proposed approach is demonstrated for different contingency cases in IEEE 30 and IEEE 118 bus systems with smooth cost functions and their results are compared with other single objective evolutionary algorithms like Particle swarm optimization (PSO and Differential evolution (DE. Simulation results show the effectiveness of the proposed approach to generate well distributed pareto-optimal non-dominated solutions of multi-objective problem

  5. Effect of substituents on prediction of TLC retention of tetra-dentate Schiff bases and their Copper(II) and Nickel(II) complexes.

    Science.gov (United States)

    Stevanović, Nikola R; Perušković, Danica S; Gašić, Uroš M; Antunović, Vesna R; Lolić, Aleksandar Đ; Baošić, Rada M

    2017-03-01

    The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normal- and reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal- and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity. Copyright © 2016 John Wiley & Sons, Ltd.

  6. Synthesis and luminescent properties of novel Cu (II), Zn (II) polymeric complexes based on 1,10-phenanthroline and biphenyl groups

    Indian Academy of Sciences (India)

    Yan He; Chaofan Zhong; Yu Zhou; Hailiang Zhang

    2009-07-01

    A fully conjugated ligand 4,4'-bis(1,10-phenanthroline-[5,6-d]imidazole-2-yl)-biphenyl (BPIBP) based on 1,10-phenanthroline and biphenyl groups was firstly synthesized. The corresponding polymeric complexes, BPIBP (1) with Cu(II) (2) and Zn(II) (3), were synthesized and characterized by FT-IR, elemental Analysis, conductivity measurement. UV-Vis and fluorescence spectra at room temperature revealed that both the polymeric complexes 2 and 3 emit blue luminescence at 453 and 452 nm (em, max) in DMSO solution and blue/green luminescence at 527 and 536 nm (em, max) in solid state respectively, and the maximum wavelengths of the polymeric complexes 2 and 3 are red shifted, compared with the ligand 1. Thermal property measurements show that they have good thermal stability.

  7. Synthesis and Properties of New Molecule-Based Magnets Containing Mn(II, Cu(II and Nitronyl Nitroxide Radical Cation

    Directory of Open Access Journals (Sweden)

    Vaz Maria G. F.

    2002-01-01

    Full Text Available In this work, we describe the synthesis of two new copper(II compounds, (Pr-Rad2 [Cu(opba].H2O (1 and (Bu-Rad2[Cu(opba].2H2O (2 where opba stands for ortho-phenylenebis(oxamato and RRad+ are nitronyl nitroxide radical cations. From 1 and 2, two new molecule-based magnets [Pr-Rad]2[Mn2{Cu(opba}3 ].3.3DMSO.5H2O (3 and [Bu-Rad]2 [Mn2{Cu(opba}3].3DMSO.6H 2O (4 were obtained, respectively. The magnetic properties of precursors 1 and 2 show the presence of ferromagnetic interaction between the radical cations with copper(II, in the temperature range of 20-300 K. The magnets 3 and 4 exhibit spontaneous magnetization at critical temperatures, Tc, of 23 K and 24 K, respectively.

  8. Dental cavity liners for Class I and Class II resin-based composite restorations.

    Science.gov (United States)

    Schenkel, Andrew B; Peltz, Ivy; Veitz-Keenan, Analia

    2016-10-25

    Resin-based composite (RBC) is currently accepted as a viable material for the restoration of caries for posterior permanent teeth requiring surgical treatment. Despite the fact that the thermal conductivity of the RBC restorative material closely approximates that of natural tooth structure, postoperative hypersensitivity is sometimes still an issue. Dental cavity liners have historically been used to protect the pulp from the toxic effects of some dental restorative materials and to prevent the pain of thermal conductivity by placing an insulating layer between restorative material and the remaining tooth structure. The objective of this review was to assess the effects of using dental cavity liners in the placement of Class I and Class II resin-based composite posterior restorations in permanent teeth in children and adults. Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 25 May 2016), the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 4) in the Cochrane Library (searched 25 May 2016), MEDLINE Ovid (1946 to 25 May 2016), Embase Ovid (1980 to 25 May 2016) and LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science Information database; 1982 to 25 May 2016). We searched ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform for ongoing trials. No restrictions were placed on the language or date of publication when searching the electronic databases. We included randomized controlled trials assessing the effects of the use of liners under Class I and Class II posterior resin-based composite restorations in permanent teeth (in both adults and children). We included both parallel and split-mouth designs. We utilized standard methodological procedures prescribed by Cochrane for data collection and analysis. Two review authors screened the search results and assessed the eligibility of studies for

  9. Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study

    DEFF Research Database (Denmark)

    Thomsen, M; Nordestgaard, B G; Tybjærg-Hansen, Anne

    2011-01-01

    The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whet...

  10. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity.

    Science.gov (United States)

    Sengupta, Poulomi; Basu, Sudipta; Soni, Shivani; Pandey, Ambarish; Roy, Bhaskar; Oh, Michael S; Chin, Kenneth T; Paraskar, Abhimanyu S; Sarangi, Sasmit; Connor, Yamicia; Sabbisetti, Venkata S; Kopparam, Jawahar; Kulkarni, Ashish; Muto, Katherine; Amarasiriwardena, Chitra; Jayawardene, Innocent; Lupoli, Nicola; Dinulescu, Daniela M; Bonventre, Joseph V; Mashelkar, Raghunath A; Sengupta, Shiladitya

    2012-07-10

    Nanoscale drug delivery vehicles have been harnessed extensively as carriers for cancer chemotherapeutics. However, traditional pharmaceutical approaches for nanoformulation have been a challenge with molecules that exhibit incompatible physicochemical properties, such as platinum-based chemotherapeutics. Here we propose a paradigm based on rational design of active molecules that facilitate supramolecular assembly in the nanoscale dimension. Using cisplatin as a template, we describe the synthesis of a unique platinum (II) tethered to a cholesterol backbone via a unique monocarboxylato and O→Pt coordination environment that facilitates nanoparticle assembly with a fixed ratio of phosphatidylcholine and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino (polyethylene glycol)-2000]. The nanoparticles formed exhibit lower IC(50) values compared with carboplatin or cisplatin in vitro, and are active in cisplatin-resistant conditions. Additionally, the nanoparticles exhibit significantly enhanced in vivo antitumor efficacy in murine 4T1 breast cancer and in K-Ras(LSL/+)/Pten(fl/fl) ovarian cancer models with decreased systemic- and nephro-toxicity. Our results indicate that integrating rational drug design and supramolecular nanochemistry can emerge as a powerful strategy for drug development. Furthermore, given that platinum-based chemotherapeutics form the frontline therapy for a broad range of cancers, the increased efficacy and toxicity profile indicate the constructed nanostructure could translate into a next-generation platinum-based agent in the clinics.

  11. Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate ONO donor Schiff base ligand: Synthesis, characterization, thermal, non-isothermal kinetics and DFT calculations

    Science.gov (United States)

    Kusmariya, Brajendra S.; Mishra, A. P.

    2017-02-01

    We report here four mononuclear Co(II), Ni(II), Cu(II) and Zn(II) coordination compounds of general formula [M(L)2] {L = dcp; M = CoII, CuII & ZnII} and [M(L)(H2O)]·H2O {L = dcp; M = NiII} derived from tridentate 2,4-dichloro-6-{[(3-chloro-2-hydroxy-5-nitrophenyl)imino]methyl}phenol (dcp) ligand. These compounds were synthesized and characterized by elemental analysis, FT-IR, uv-vis, 1H NMR, molar conductance, magnetic moment, thermal, PXRD and SEM-EDX. The Powder X-ray Diffraction patterns and SEM analyses showed the crystalline nature of synthesized compounds. The peak broadening was explained in terms of crystallite size and the lattice strain using Scherrer and Williamson-Hall method. Thermogravimetric analysis was performed to determine the thermal stability of synthesized compounds under nitrogen atmosphere up to 820 K at 10 Kmin-1 heating rate. The kinetic and thermodynamic parameters of thermal decomposition were calculated using Coats-Redfern (C-R), Piloyan-Novikova (P-N) and Horowitz-Metzger (H-M) methods assuming first order degradation. The calculated optical band gap values of complexes were found to be in semiconducting range. To support the experimental findings, and derive some fruitful information viz. frequency calculations, HOMO-LUMO, energy gap (ΔE), molecular electrostatic potential (MEP), spin density, absorption spectra etc.; theoretical calculations by means of DFT and TD-DFT at B3LYP level were incorporated.

  12. Crystal structure of a new hybrid compound based on an iodido-plumbate(II) anionic motif.

    Science.gov (United States)

    Mokhnache, Oualid; Boughzala, Habib

    2016-01-01

    Crystals of the one-dimensional organic-inorganic lead iodide-based compound catena-poly[bis-(piperazine-1,4-diium) [[tetra-iodido-plumbate(II)]-μ-iodido] iodide monohydrate], (C4N2H12)2[PbI5]I·H2O, were obtained by slow evaporation at room temperature of a solution containing lead iodide and piperazine in a 1:2 molar ratio. Inorganic lead iodide chains, organic (C4N2H12)(2+) cations, water mol-ecules of crystallization and isolated I(-) anions are connected through N-H⋯·I, N-H⋯OW and OW-H⋯I hydrogen-bond inter-actions. Zigzag chains of corner-sharing [PbI6](4-) octa-hedra with composition [PbI4/1I2/2](3-) running parallel to the a axis are present in the structure packing.

  13. Design of Networked Home Automation System Based on μCOS-II and AMAZON

    Directory of Open Access Journals (Sweden)

    Liu Jianfeng

    2015-01-01

    Full Text Available In recent years, with the popularity of computers and smart phones and the development of intelligent building in electronics industry, people’s requirement of living environment is gradually changing. The intelligent home furnishing building has become the new focus of people purchasing. And the networked home automation system which relies on the advanced network technology to connect with air conditioning, lighting, security, curtains, TV, water heater and other home furnishing systems into a local area network becomes a networked control system. μC /OS is a real-time operating system with the free open-source code, the compact structure and the preemptive real-time kernel. In this paper, the author focuses on the design of home furnishing total controller based on AMAZON multimedia processor and μC/OS-II real-time operating system, and achieves the remote access connection and control through the Ethernet.

  14. A Low Cost Matching Motion Estimation Sensor Based on the NIOS II Microprocessor

    Directory of Open Access Journals (Sweden)

    Diego González

    2012-09-01

    Full Text Available This work presents the implementation of a matching-based motion estimation sensor on a Field Programmable Gate Array (FPGA and NIOS II microprocessor applying a C to Hardware (C2H acceleration paradigm. The design, which involves several matching algorithms, is mapped using Very Large Scale Integration (VLSI technology. These algorithms, as well as the hardware implementation, are presented here together with an extensive analysis of the resources needed and the throughput obtained. The developed low-cost system is practical for real-time throughput and reduced power consumption and is useful in robotic applications, such as tracking, navigation using an unmanned vehicle, or as part of a more complex system.

  15. Crystal structure of a new hybrid compound based on an iodidoplumbate(II anionic motif

    Directory of Open Access Journals (Sweden)

    Oualid Mokhnache

    2016-01-01

    Full Text Available Crystals of the one-dimensional organic–inorganic lead iodide-based compound catena-poly[bis(piperazine-1,4-diium [[tetraiodidoplumbate(II]-μ-iodido] iodide monohydrate], (C4N2H122[PbI5]I·H2O, were obtained by slow evaporation at room temperature of a solution containing lead iodide and piperazine in a 1:2 molar ratio. Inorganic lead iodide chains, organic (C4N2H122+ cations, water molecules of crystallization and isolated I− anions are connected through N—H...·I, N—H...OW and OW—H...I hydrogen-bond interactions. Zigzag chains of corner-sharing [PbI6]4− octahedra with composition [PbI4/1I2/2]3− running parallel to the a axis are present in the structure packing.

  16. Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization.

    Science.gov (United States)

    Youn, Sihyun; Kim, Kyung Im; Ptacek, Jakub; Ok, Kiwon; Novakova, Zora; Kim, YunHye; Koo, JaeHyung; Barinka, Cyril; Byun, Youngjoo

    2015-11-15

    Glutamate carboxypeptidase II (GCPII) is a zinc metalloprotease on the surface of astrocytes which cleaves N-acetylaspartylglutamate to release N-acetylaspartate and glutamate. GCPII inhibitors can decrease glutamate concentration and play a protective role against apoptosis or degradation of brain neurons. Herein, we report the synthesis and structural analysis of novel carborane-based GCPII inhibitors. We determined the X-ray crystal structure of GCPII in complex with a carborane-containing inhibitor at 1.79Å resolution. The X-ray analysis revealed that the bulky closo-carborane cluster is located in the spacious entrance funnel region of GCPII, indicating that the carborane cluster can be further structurally modified to identify promising lead structures of novel GCPII inhibitors.

  17. Dimensional optimization of a minimally invasive surgical robot system based on NSGA-II algorithm

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2015-02-01

    Full Text Available Based on the proposed end-effector structure of a laparoscopic minimally invasive surgical manipulator, a dimensional optimization method is investigated to enlarge the motion range of the mechanical arm in the specific target area and reduce the collision among the mechanical arms simultaneously. Both the length of the kinematics links and the overall size of the integrated system are considered in the optimization process. The NSGA-II algorithm oriented to the multi-objective optimization is utilized to calculate the Pareto solution set of the objective function. Finally, the dependence of the evaluation indexes is analysed to filter the non-inferior set, which guarantees the selection of the optimization solution.

  18. Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold.

    Science.gov (United States)

    Shahin, Mai I; Abou El Ella, Dalal A; Ismail, Nasser S M; Abouzid, Khaled A M

    2014-10-01

    In an effort to develop ATP-competitive VEGFR-2 selective inhibitors, a series of new quinoxaline-based derivatives was designed and synthesized. The target compounds were biologically evaluated for their inhibitory activity against VEGFR-2. The design of the target compounds was accomplished after a profound study of the structure activity relationship (SAR) of type-II VEGFR-2 inhibitors. Among the synthesized compounds, 1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4 dihydroquinoxalin-6-yl)-3-phenylurea (VIIa) displayed the highest inhibitory activity against VEGFR-2. Molecular modeling study involving molecular docking and field alignment was implemented to interpret the variable inhibitory activity of the newly synthesized compounds.

  19. Ruthenium(II) complexes containing quinone based ligands: Synthesis, characterization, catalytic applications and DNA interaction

    Science.gov (United States)

    Anitha, P.; Manikandan, R.; Endo, A.; Hashimoto, T.; Viswanathamurthi, P.

    2012-12-01

    1,2-Naphthaquinone reacts with amines such as semicarbazide, isonicotinylhydrazide and thiosemicarbazide in high yield procedure with the formation of tridentate ligands HLn (n = 1-3). By reaction of ruthenium(II) starting complexes and quinone based ligands HLn (n = 1-3), a series of ruthenium complexes were synthesized and characterized by elemental and spectroscopic methods (FT-IR, electronic, 1H, 13C, 31P NMR and ESI-MS). The ligands were coordinated to ruthenium through quinone oxygen, imine nitrogen and enolate oxygen/thiolato sulfur. On the basis of spectral studies an octahedral geometry may be assigned for all the complexes. Further, the catalytic oxidation of primary, secondary alcohol and transfer hydrogenation of ketone was carried out. The DNA cleavage efficiency of new complexes has also been tested.

  20. Research-Based Course Materials and Assessments for Upper-Division Electrodynamics (E&M II)

    CERN Document Server

    Baily, Charles; Pollock, Steven J

    2012-01-01

    Favorable outcomes from ongoing research at the University of Colorado Boulder on student learning in junior-level electrostatics (E&M I) have led us to extend this work to upper-division electrodynamics (E&M II). We describe here our development of a set of research-based instructional materials designed to actively engage students during lecture (including clicker questions and other in-class activities); and an instrument for assessing whether our faculty-consensus learning goals are being met. We also discuss preliminary results from several recent implementations of our transformed curriculum, plans for the dissemination and further refinement of these materials, and offer some insights into student difficulties in advanced undergraduate electromagnetism.

  1. Cooperation in Carrier Sense Based Wireless Ad Hoc Networks - Part II: Proactive Schemes

    CERN Document Server

    Munari, Andrea; Zorzi, Michele

    2012-01-01

    This work is the second of a two-part series of papers on the effectiveness of cooperative techniques in non-centralized carrier sense-based ad hoc wireless networks. While Part I extensively discussed reactive cooperation, characterized by relayed transmissions triggered by failure events at the intended receiver, Part II investigates in depth proactive solutions, in which the source of a packet exploits channel state information to preemptively coordinate with relays in order to achieve the optimal overall rate to the destination. In particular, this work shows by means of both analysis and simulation that the performance of reactive cooperation is reduced by the intrinsic nature of the considered medium access policy, which biases the distribution of the available relays, locating them in unfavorable positions for rate optimization. Moreover, the highly dynamic nature of interference that characterizes non-infrastructured ad hoc networks is proved to hamper the efficacy and the reliability of preemptively ...

  2. Synthesis, crystal structure, fluorescence and electrochemical studies of a new tridentate Schiff base ligand and its nickel(II) and palladium(II) complexes

    Science.gov (United States)

    Shafaatian, Bita; Soleymanpour, Ahmad; Kholghi Oskouei, Nasim; Notash, Behrouz; Rezvani, Seyyed Ahmad

    2014-07-01

    A new unsymmetrical tridentate Schiff base ligand was derived from the 1:1 M condensation of ortho-vanillin with 2-mercaptoethylamine. Nickel and palladium complexes were obtained by the reaction of the tridentate Schiff base ligand with nickel(II) acetate tetrahydrate and palladium(II) acetate in 2:1 M ratio. In nickel and palladium complexes the ligand was coordinated to metals via the imine N and enolic O atoms. The S groups of Schiff bases were not coordinated to the metals and S-S coupling was occured. The complexes have been found to possess 1:2 Metal:Ligand stoichiometry and the molar conductance data revealed that the metal complexes were non-electrolytes. The complexes exhibited octahedral coordination geometry. The emission spectra of the ligand and its complexes were studied in methanol. Electrochemical properties of the ligand and its metal complexes were investigated in the CH3CN solvent at the 100 mV s-1 scan rate. The ligand and metal complexes showed both reversible and quasi-reversible processes at this scan rate. The Schiff base and its complexes have been characterized by IR, 1H NMR, UV/Vis, elemental analyses and conductometry. The crystal structure of nickel complex has been determined by single crystal X-ray diffraction.

  3. Synthesis, spectroscopic and DNA binding ability of Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff base ligand (E)-1-(((1H-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol. X-ray crystal structure determination of cobalt (II) complex.

    Science.gov (United States)

    Yarkandi, Naeema H; El-Ghamry, Hoda A; Gaber, Mohamed

    2017-06-01

    A novel Schiff base ligand, (E)-1-(((1H-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol (HL), has been designed and synthesized in addition to its metal chelates [Co(L)2]·l2H2O, [Ni(L)Cl·(H2O)2].5H2O, [Cu(L)Cl] and [Zn(L)(CH3COO)]. The structures of the isolated compounds have been confirmed and identified by means of different spectral and physicochemical techniques including CHN analysis, (1)H &(13)C NMR, mass spectral analysis, molar conductivity measurement, UV-Vis, infrared, magnetic moment in addition to TGA technique. The infrared spectral results ascertained that the ligand acts as monobasic tridentate binding to the metal centers via deprotonated hydroxyl oxygen, azomethine and imidazole nitrogen atoms. The UV-Vis, magnetic susceptibility and molar conductivity data implied octahedral geometry for Co(II) & Ni(II) complexes, tetrahedral for Zn(II) complex and square planar for Cu(II) complex. X-ray structural analysis of Co(II) complex 1 has been reported and discussed. Moreover, the type of interaction between the ligand & its complexes towards salmon sperm DNA (SS-DNA) has been examined by the measurement of absorption spectra and viscosity which confirmed that the ligand and its complexes interact with DNA via intercalation interaction as concluded from the values of binding constants (Kb). Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Use of Manganese(II)-Schiff Base Complexes for Carrying Polar Organometallics and Inorganic Ion Pairs.

    Science.gov (United States)

    Gallo, Emma; Solari, Euro; Floriani, Carlo; Chiesi-Villa, Angiola; Rizzoli, Corrado

    1997-05-07

    This report concerns the carrier properties of [Mn(acacen)]-derived compounds toward polar organometallics, inorganic ion pairs, and salts. Such properties are the consequence of Mn(II) behaving as a Lewis acid and the O&arcraise;O bite of the bidentate Schiff base ligand toward alkali cations. The starting compounds, which occur in a dimeric form, [Mn(acac-L-en)](2) [L' = CH(2)CH(2) (1); L" = C(6)H(10) (2); L"' = R,R-C(6)H(10) (3)] have been synthesized either via a metathesis reaction from MnCl(2) or using [Mn(3)Mes(6)]. The reaction of 1-3 with lithium organometallics allowed the isolation of [Mn(acac-L-en)(R)Li(DME)] [R = Me, L = L' (4); R = Ph, L = L' (5); R = Mes, L = L' (6); R = Me, L = L" (7); R = Me, L = L"' (8)] as metalated forms, where the alkyl or aryl group is sigma-bonded to Mn(II), while the lithium cation is anchored to the Schiff base ligand. The metalated forms 4-8 react with PhCHO to give the corresponding lithium alkoxide, which remains bound in its ion-pair form to the [Mn(acacen)] skeleton in [Mn(2)(acac-L'-en)(2)Li(2)(OCH(Ph)Me)(2)](n)() (9). The use of 8, which has a chiral bridge across two nitrogen atoms, did not lead to a significant asymmetric induction in the reaction with PhCHO, because of the long separation between the lithium cation and the stereogenic center. The metalated form 4 was able to transfer the methyl group to the nitrile function to give the corresponding lithium-imide which then remains bonded to [Mn(acacen)] as the ion pair in a dimeric structure, as revealed for [Mn(2)(acac-L'-en)(2)Li(2)(DME){N=C(Ph)Me}(2)](n)() (10). Their reaction with 1 appears to depend on the steric bulkiness of the alkyl group in NaOR, resulting in either monomeric adducts, i.e. in [Mn(acac-L'-en)(2,6-Bu(t)(2)C(6)H(3)O)Na(DME)(2)] (11.2DME), or polymeric structures, like in [Mn(acac-L'-en)Na(DME)(&mgr;-OEt)](n)() (13). All the dimeric units reported in this paper show a slight antiferromagnetic coupling between the two Mn(II) assisted by

  5. Synthesis, crystal structure, spectral characterization and photoluminescence property of three Cd(II) complexes with a pyrazole based Schiff-base ligand

    Science.gov (United States)

    Mandal, Susmita; Saha, Rajat; Saha, Manan; Pradhan, Rajesh; Butcher, Ray J.; Saha, Nitis Chandra

    2016-04-01

    Substituted pyrazole containing Schiff-base ligand, 5-methyl-3-formylpyrazole-N-(2‧-methylphenoxy)methyleneimine, (MPzOA), afforded three new Cd(II) complexes, [Cd(MPzOA)Cl2]2.CH3OH (I), [Cd(MPzOA)2(H2O)2](ClO4)2 (II) and [Cd(MPzOA)(H2O)(NO3)2] (III). In the reported complex species the coordination number and geometry of Cd(II) vary. In complex I and II, Cd(II) adopts six and in (III) it adopts eight coordination modes, with prismatic, octahedral and distorted dodecahedral geometry, respectively. All the complexes are characterized by IR, 1H NMR, UV-Vis spectral parameters and X-ray analyses. The complexes have 1D, 2D and 3D supramolecular frameworks formed by non-covalent interactions, like hydrogen bonding, π … π stacking, C-H … π interactions.

  6. Investigation of irradiated rats DNA in the presence of Cu(II) chelates of amino acids Schiff bases.

    Science.gov (United States)

    Karapetyan, N H; Torosyan, A L; Malakyan, M; Bajinyan, S A; Haroutiunian, S G

    2016-01-01

    The new synthesized Cu(II) chelates of amino acids Schiff bases were studied as a potential radioprotectors. Male albino rats of Wistar strain were exposed to X-ray whole-body irradiation at 4.8 Gy. This dose caused 30% mortality of the animals (LD30). The survival of animals exposed to radiation after preliminary administration of 10 mg/kg Cu(II)(Nicotinyl-L-Tyrosinate)2 or Cu(II)(Nicotinyl-L-Tryptophanate)2 prior to irradiation was registered about 80 and 100% correspondingly. Using spectrophotometric melting and agarose gel electrophoresis methods, the differences between the DNA isolated from irradiated rats and rats pretreated with Cu(II) chelates were studied. The fragments of DNA with different breaks were revealed in DNA samples isolated from irradiated animals. While, the repair of the DNA structure was observed for animals pretreated with the Cu(II) chelates. The results suggested that pretreatment of the irradiated rats with Cu(II)(Nicotinyl-L-Tyrosinate)2 and Cu(II)(Nicotinyl-L-Tryptophanate)2 compounds improves the liver DNA characteristics.

  7. Polyacrylonitrile-based fiber modified with thiosemicarbazide by microwave irradiation and its adsorption behavior for Cd(II) and Pb(II)

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Sheng [State Key Laboratory of Urban Water Resource and Environment, Harbin 150090 (China); School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China); Wang, Peng, E-mail: pwang73@vip.sina.com [State Key Laboratory of Urban Water Resource and Environment, Harbin 150090 (China); School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China); Zhang, Guangshan, E-mail: gszhanghit@gmail.com [School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China); Dou, Yuan [Shanxi Research Academy of Environmental Science, Taiyuan 030027 (China)

    2016-04-15

    Highlights: • Thiosemicarbazide modified fibrous adsorbents were prepared by MW irradiation. • Compared with conventional method, MW irradiation showed higher efficiency and yield. • The PAN{sub MW}–TSC fiber exhibited high adsorption capacities for Cd(II) and Pb(II). • The PAN{sub MW}–TSC fibers can be readily regenerated by 0.5 M HNO{sub 3} solution. - Abstract: A novel thiosemicarbazide modified adsorbent (PAN{sub MW}–TSC) based on polyacrylonitrile fiber was successfully synthesized under microwave irradiation, which was applied for the uptake of Cd(II) and Pb(II) from aqueous solution subsequently. Microwave irradiation method is a new approach to achieve the modification and it turns out that just a 30 min process is enough for the anchoring of functional groups in the fiber matrix. The surface characterization was performed by fourier transform infrared spectroscopy (FT–IR), scanning electron microscopy (SEM) elemental analysis (EA) and thermogravimetric analysis (TGA), indicating that the modification was successfully accomplished. Batch adsorption experiments including equilibrium isotherms, kinetics and the effects of pH and temperature on the adsorption of Cd(II) and Pb(II) were systematically studied. Among three kinetic models, the pseudo-second-order kinetic model provides the best correlation for the process. The nonlinear resolution of the Langmuir isotherm equation has been found to show the closest fit to the equilibrium date. Thermodynamic parameters, involving △G, △H and △S were also calculated from graphical interpretation of the experimental data, which suggest that metal ions adsorption onto PAN{sub MW}–TSC fibers is spontaneous and exothermic. Regeneration of PAN{sub MW}–TSC fibers loaded with metal ions was efficiently done with 0.5 M HNO{sub 3}, by which the investigated adsorbent could be used reproductively for five times with a small decrease in sorption capacity. The feasible preparation of PAN{sub MW

  8. 1D zigzag chain and 0D monomer Cd(II)/Zn(II) compounds based on flexible phenylenediacetic ligand: Synthesis, crystal structures and fluorescent properties

    Science.gov (United States)

    Yang, Fang; Ren, Yixia; Li, Dongsheng; Fu, Feng; Qi, Guangcai; Wang, Yaoyu

    2008-12-01

    Three novel Cd(II)/Zn(II) compounds, [Cd 2(poda) 2(phen) 3(H 2O)] n· nEtOH·3 nH 2O (1), [Zn(poda) 2(bpy)(H 2O)] n(2) and [Zn(Hpoda) 2(bpy)] (3) (H 2poda = 1,2-phenylenediacetic acid, phen = 1,10-phenanthroline, bpy = 2,2'-bipyridyl), have been synthesized and characterized by IR, TG, fluorescent spectrum and single-crystal X-ray diffraction techniques. In 1, poda 2- anions link the adjacent Cd(II) centers to generate a 1D zigzag chain. Furthermore, an unprecedented four-footed "8-shaped" mixed water-ethanol (H 2O) 6(C 2H 5OH) 2 cluster connects four double chains based on 1D zigzag chain into 3D supramolecular architecture. By bis(chelate-monodentate) fashion of poda 2- ligand, compound 2 exhibits 1D zigzag chains, which forming a dense zipper-like 2D structure via strong π-π stacking interactions. Differed from 1 and 2, compound 3 has a mononuclear motif, and displays a 3D 6-connected α-Po net hydrogen-bonded topology. The structure-related solid-state fluorescence spectra of compounds 1 and 2 have been determined.

  9. Selective separation of mercury(II) using magnetic chitosan resin modified with Schiff's base derived from thiourea and glutaraldehyde.

    Science.gov (United States)

    Donia, Ahmed M; Atia, Asem A; Elwakeel, Khalid Z

    2008-03-01

    Magnetic chitosan resin was chemically modified by a Schiff's base cross-linker. The interaction of the resin obtained with Hg(II) was studied and uptake value of 2.8 mmol/g was reported. The kinetic and thermodynamic parameters of the adsorption process were estimated. These data indicated that the adsorption process is exothermic and follow the pseudo-second-order kinetics. The selectivity of Hg(II) from other different metal ions in solutions using the studied resin was also reported. Breakthrough curves for the recovery of Hg(II) were studied. The critical bed height was found to be 2.05 cm. The adsorbed Hg(II) was eluted from the resin effectively using 0.1 M potassium iodide.

  10. Preconcentration of Ni(II on Silica gel Loaded with New Synthesized Schiff base and their Determination by FAAS

    Directory of Open Access Journals (Sweden)

    Hamed Masoudinia

    2014-12-01

    Full Text Available A preconcentration method was developed for the determination of trace amounts of Ni(II by atomic absorption spectrometry. The method is based on the retention of the metal cations by modified silica gel adsorbent. The adsorbed metals were then eluted with nitric acid and the Ni(II was determined by flame atomic absorption spectrometry. The optimal extraction and elution conditions were studied. The effects of diverse ions on the preconcentration were also investigated. A preconcentration factor of 100 can easily be achieved. Calibration graph was obtained and the detection limit of the method for Ni(II was 1.3 ng mL-1. The relative standard deviation (RSD of 0.66–1.32 % was obtained. The method was applied successfully to the determination of Ni(II in water samples.

  11. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lund, Ole

    2009-01-01

    through presentation of extracellularly derived peptides to helper T cells. Identification of which peptides will bind a given MHC molecule is thus of great importance for the understanding of host-pathogen interactions, and large efforts have been placed in developing algorithms capable of predicting...... this binding event. RESULTS: Here, we present a novel artificial neural network-based method, NN-align that allows for simultaneous identification of the MHC class II binding core and binding affinity. NN-align is trained using a novel training algorithm that allows for correction of bias in the training data...... class II alleles, and is demonstrated to outperform other state-of-the-art MHC class II prediction methods. CONCLUSION: The NN-align method is competitive with the state-of-the-art MHC class II peptide binding prediction algorithms. The method is publicly available at http...

  12. Population-based public health interventions: innovations in practice, teaching, and management. Part II.

    Science.gov (United States)

    Keller, Linda Olson; Strohschein, Susan; Schaffer, Marjorie A; Lia-Hoagberg, Betty

    2004-01-01

    The Intervention Wheel is a population-based practice model that encompasses three levels of practice (community, systems, and individual/family) and 17 public health interventions. Each intervention and practice level contributes to improving population health. The Intervention Wheel, previously known as the Public Health Intervention Model, was originally introduced in 1998 by the Minnesota Department of Health, Section of Public Health Nursing (PHN). The model has been widely disseminated and used throughout the United States since that time. The evidence supporting the Intervention Wheel was recently subjected to a rigorous critique by regional and national experts. This critical process, which involved hundreds of public health nurses, resulted in a more robust Intervention Wheel and established the validity of the model. The critique also produced basic steps and best practices for each of the 17 interventions. Part I describes the Intervention Wheel, defines population-based practice, and details the recommended modifications and validation process. Part II provides examples of the innovative ways that the Intervention Wheel is being used in public health/PHN practice, education, and administration. The two articles provide a foundation and vision for population-based PHN practice and direction for improving population health.

  13. An Insight into the Anticancer Activities of Ru(II-Based Metallocompounds Using Docking Methods

    Directory of Open Access Journals (Sweden)

    Peter A. Ajibade

    2013-09-01

    Full Text Available Unlike organic molecules, reports on docking of metal complexes are very few; mainly due to the inadequacy of force fields in docking packages to appropriately characterize the metal atoms that consequentially hinder the rational design of metal-based drug complexes. In this study we have made used Molegro and Autodock to predict the anticancer activities of selected Ru(II complexes against twelve anticancer targets. We observed that introducing the quantum calculated atomic charges of the optimized geometries significantly improved the docking predictions of these anticancer metallocompounds. Despite several limitations in the docking of metal-based complexes, we obtained results that are highly correlated with the available experimental results. Most of our newly proposed metallocompounds are found theoretically to be better anticancer metallocompounds than all the experimentally proposed RAPTA complexes. An interesting features of a strong interactions of new modeled of metallocompounds against the two base edges of DNA strands suggest similar mechanisms of anticancer activities similar to that of cisplatin. There is possibility of covalent bonding between the metal center of the metallocompounds and the residues of the receptors DNA-1, DNA-2, HDAC7, HIS and RNR. However, the general results suggest the possibility of metals positioning the coordinated ligands in the right position for optimal receptor interactions and synergistic effects, rather than forming covalent bonds.

  14. Energy Economic Data Base (EEDB) Program: Phase I, Volume II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    This Volume II of Phase I of the Energy Economic Data Base Program contains appendices. Appendix A-1 provides the site and environmental data, derived from Appendix A of Guide for Economic Evaluation of Nuclear Reactor Plant Designs, USAEC Report NUS-531, modified to reflect current requirements. These data form the bases of the criteria used for designing the facility and for evaluating the routine and accidental release of radioactive liquids and gases to the environment. Appendix A-2 provides the site and environmental data as derived from Appendix A of NUS-531, and modified to reflect coal-plant siting, forming the bases of the criteria used for designing the facility and for evaluating the release of liquids and gases to the environment. A description of the topography of the hypothetical city, Middletown, is given. Appendix B provides an overall summary of the conclusions of NUS' work on all NUS tasks in support of the nuclear fuel-cycle work in Phase I. Appendix C-1 introduces the concepts involved and addresses methods of calculation of fixed charges applicable to investor-owned utilities, as used in the EEDB. Appendix C-2 consists of review and revision of each plant's fuel cycle and operating and maintenance costs in accordance with the EEDB update procedures. In Appendix D, NSSS Capital Costs for a Mature LMFBR Industry, much information is provided on plant description, cost estimate, comparison and discussion, drawings, and equipment list. (MCW)

  15. Ruthenium(II) hydrazone Schiff base complexes: synthesis, spectral study and catalytic applications.

    Science.gov (United States)

    Manikandan, R; Viswanathamurthi, P; Muthukumar, M

    2011-12-01

    Ruthenium(II) hydrazone Schiff base complexes of the type [RuCl(CO)(B)(L)] (were B=PPh(3), AsPh(3) or Py; L=hydrazone Schiff base ligands) were synthesized from the reactions of hydrazone Schiff base ligand (obtained from isonicotinoylhydrazide and different hydroxy aldehydes) with [RuHCl(CO)(EPh(3))(2)(B)] (where E=P or As; B=PPh(3), AsPh(3) or Py) in 1:1 molar ratio. All the new complexes have been characterized by analytical and spectral (FT-IR, electronic, (1)H, (13)C and (31)P NMR) data. They have been tentatively assigned an octahedral structure. The synthesized complexes have exhibited catalytic activity for oxidation of benzyl alcohol to benzaldehyde and cyclohexanol to cyclohexanone in the presence of N-methyl morpholine N-oxide (NMO) as co-oxidant. They were also found to catalyze the transfer hydrogenation of aliphatic and aromatic ketones to alcohols in KOH/Isopropanol.

  16. Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Barinka, Cyril; Byun, Youngjoo; Dusich, Crystal L.; Banerjee, Sangeeta R.; Chen, Ying; Castanares, Mark; Kozikowski, Alan P.; Mease, Ronnie C.; Pomper, Martin G.; Lubkowski, Jacek (NCI); (JHMI); (UIC)

    2009-01-21

    Urea-based, low molecular weight ligands of glutamate carboxypeptidase II (GCPII) have demonstrated efficacy in various models of neurological disorders and can serve as imaging agents for prostate cancer. To enhance further development of such compounds, we determined X-ray structures of four complexes between human GCPII and urea-based inhibitors at high resolution. All ligands demonstrate an invariant glutarate moiety within the S1{prime} pocket of the enzyme. The ureido linkage between P1 and P1{prime} inhibitor sites interacts with the active-site Zn{sub 1}{sup 2+} ion and the side chains of Tyr552 and His553. Interactions within the S1 pocket are defined primarily by a network of hydrogen bonds between the P1 carboxylate group of the inhibitors and the side chains of Arg534, Arg536, and Asn519. Importantly, we have identified a hydrophobic pocket accessory to the S1 site that can be exploited for structure-based design of novel GCPII inhibitors with increased lipophilicity.

  17. Topology optimization of support structure of telescope skin based on bit-matrix representation NSGA-II

    Institute of Scientific and Technical Information of China (English)

    Liu Weidong; Zhu Hua; Wang Yiping; Zhou Shengqiang; Bai Yalei; Zhao Chunsheng

    2013-01-01

    Non-dominated sorting genetic algorithm II (NSGA-II) with multiple constraints han-dling is employed for multi-objective optimization of the topological structure of telescope skin, in which a bit-matrix is used as the representation of a chromosome, and genetic algorithm (GA) operators are introduced based on the matrix. Objectives including mass, in-plane performance, and out-of-plane load-bearing ability of the individuals are obtained by finite element analysis (FEA) using ANSYS, and the matrix-based optimization algorithm is realized in MATLAB by han-dling multiple constraints such as structural connectivity and in-plane strain requirements. Feasible configurations of the support structure are achieved. The results confirm that the matrix-based NSGA-II with multiple constraints handling provides an effective method for two-dimensional multi-objective topology optimization.

  18. Chiral discrimination asserted by enantiomers of Ni (II), Cu (II) and Zn (II) Schiff base complexes in DNA binding, antioxidant and antibacterial activities.

    Science.gov (United States)

    Khan, Noor-ul Hasan; Pandya, Nirali; Prathap, K Jeya; Kureshy, Rukhsana Ilays; Abdi, Sayed Hasan Razi; Mishra, Sandhya; Bajaj, Hari Chandra

    2011-10-15

    Chiral Schiff base ligands (S)-H(2)L and (R)-H(2)L and their complexes (S-Ni-L, R-Ni-L, S-Cu-L, R-Cu-L, S-Zn-L and R-Zn-L) were synthesized, characterized and examined for their DNA binding, antioxidant and antibacterial activities. The complexes showed higher binding affinity to calf thymus DNA with binding constant ranging from 2.0×10(5) to 4.5×10(6) M(-1). All the complexes also exhibited remarkable superoxide (56-99%) and hydroxyl scavenging (45-89%) activities as well as antibacterial activities against gram (+) and gram (-) bacteria. However, none of the complexes showed antifungal activity. Conclusively, S enantiomers of the complexes were found to be relatively more efficient for DNA interaction, antioxidant and antibacterial activities than their R enantiomers. This study reveals the possible utilization of chiral Schiff base complexes for pharmaceutical applications.

  19. Hematotoxicity response in rats by the novel copper-based anticancer agent: casiopeina II.

    Science.gov (United States)

    De Vizcaya-Ruiz, A; Rivero-Müller, A; Ruiz-Ramirez, L; Howarth, J A; Dobrota, M

    2003-12-15

    The in vivo toxicity of the novel copper-based anticancer agent, casiopeina II (Cu(4,7-dimethyl-1,10-phenanthroline)(glycine)NO3) (CII), was investigated. Casiopeinas are a family of copper-coordinated complexes that have shown promising anticancer activity. The major toxic effect attributed to a single i.v. administration of CII (5 mg/kg dose) in the rat was an hemolytic anemia (reduced hemoglobin concentration (HB), red blood cell (RBC) count and packed cell volume (PCV) accompanied by a marked neutrophilic leukocytosis) 12 h and 5 days after administration, attributed to a direct erythrocyte damage. Increased reticulocyte levels and presence of normoblasts in peripheral blood 5 days post-administration indicated an effective erythropoietic response with recovery at 15 days. Increase in spleen weight and the morphological evidence of congestion of the red pulp (RP) with erythrocytes (E) resulting in a higher ratio of red to white pulp (WP) was consistent with increased uptake of damaged erythrocytes by the reticuloendothelial system observed by histopathology and electron microscopy. Extramedullary hemopoiesis was markedly increased at 5 days giving further evidence of a regenerative erythropoietic response that had an effective recovery by 15 days. Morphological changes in spleen cellularity were consistent with hematotoxicity, mainly a reduction of the red pulp/white pulp ratio, increase in erythrocyte content at 12 h, and an infiltration of nucleated cells in the red pulp at 5 days, with a tendency towards recovery 15 days after administration. The erythrocyte damage is attributed to generation of free radicals and oxidative damage on the membrane and within cells resulting from the reduction of Cu(II) and the probable dissociation of the CII complex.

  20. Deriving remote sensing reflectance from turbid Case II waters using green-shortwave infrared bands based model

    Science.gov (United States)

    Chen, Jun; Yin, Shoujing; Xiao, Rulin; Xu, Qianxiang; Lin, Changsong

    2014-04-01

    The objectives of this study are to validate the applicability of a shortwave infrared atmospheric correction model (SWIR-based model) in deriving remote sensing reflectance in turbid Case II waters, and to improve that model using a proposed green-shortwave infrared model (GSWIR-based model). In a GSWIR-based model, the aerosol type is determined by a SWIR-based model and the reflectance due to aerosol scattering is calculated using spectral slope technology. In this study, field measurements collected from three independent cruises from two different Case II waters were used to compare models. The results indicate that both SWIR- and GSWIR-based models can be used to derive the remote sensing reflectance at visible wavelengths in turbid Case II waters, but GSWIR-based models are superior to SWIR-based models. Using the GSWIR-based model decreases uncertainty in remote sensing reflectance retrievals in turbid Case II waters by 2.6-12.1%. In addition, GSWIR-based model’s sensitivity to user-supplied parameters was determined using the numerical method, which indicated that the GSWIR-based model is more sensitive to the uncertainty of spectral slope technology than to that of aerosol type retrieval methodology. Due to much lower noise tolerance of GSWIR-based model in the blue and near-infrared regions, the GSWIR-based model performs poorly in determining remote sensing reflectance at these wavelengths, which is consistent with the GSWIR-based model’s accuracy evaluation results.

  1. Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases.

    Science.gov (United States)

    Bagihalli, Gangadhar B; Avaji, Prakash Gouda; Patil, Sangamesh A; Badami, Prema S

    2008-12-01

    A series of metal complexes of cobalt(II), nickel(II) and copper(II) have been synthesized with newly synthesized biologically active 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole and 8-formyl-7-hydroxy-4-methylcoumarin, which have been characterized by elemental analyses, spectroscopic measurements (IR, UV-vis, fluorescence, ESR), magnetic measurements and thermal studies. Electrochemical study of the complexes is also reported. All the complexes are soluble to limited extent in common organic solvents but soluble to larger extent in DMF and DMSO and are non-electrolytes in DMF and DMSO. All these Schiff bases and their complexes have also been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by MIC method. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.

  2. Antimicrobial, spectral, magnetic and thermal studies of Cu(II), Ni(II), Co(II), UO(2)(VI) and Fe(III) complexes of the Schiff base derived from oxalylhydrazide.

    Science.gov (United States)

    Melha, Khlood Abou

    2008-04-01

    The Schiff base ligand, oxalyl [( 2 - hydroxybenzylidene) hydrazone] [corrected].H(2)L, and its Cu(II), Ni(II), Co(II), UO(2)(VI) and Fe(III) complexes were prepared and tested as antibacterial agents. The Schiff base acts as a dibasic tetra- or hexadentate ligand with metal cations in molar ratio 1:1 or 2:1 (M:L) to yield either mono- or binuclear complexes, respectively. The ligand and its metal complexes were characterized by elemental analyses, IR, (1)H NMR, Mass, and UV-Visible spectra and the magnetic moments and electrical conductance of the complexes were also determined. For binuclear complexes, the magnetic moments are quite low compared to the calculated value for two metal ions complexes and this shows antiferromagnetic interactions between the two adjacent metal ions. The ligand and its metal complexes were tested against a Gram + ve bacteria (Staphylococcus aureus), a Gram -ve bacteria (Escherichia coli), and a fungi (Candida albicans). The tested compounds exhibited high antibacterial activities.

  3. Online data reduction with FPGA-based track reconstruction for the Belle II DEPFET pixel detector

    Energy Technology Data Exchange (ETDEWEB)

    Deschamps, Bruno; Wessel, Christian; Marinas, Carlos; Dingfelder, Jochen [Physikalisches Institut, Universitaet Bonn (Germany)

    2016-07-01

    The innermost two layers of the Belle II vertex detector at the KEK facility in Tsukuba, Japan, will be covered by high-granularity DEPFET pixel sensors (PXD). The large number of pixels leads to a maximum data rate of 256 Gbps, which has to be significantly reduced by the Data Acquisition System (DATCON). For the data reduction the hit information of the surrounding Silicon strip Vertex Detector (SVD) is utilized to define so-called Regions of Interest (ROI). Only hit information of the pixels located inside these ROIs are saved. The ROIs for the PXD are computed by reconstructing track segments from SVD data and extrapolation to the PXD. The goal is to achieve a data reduction of at least a factor of 10 with this ROI selection. All the necessary processing stages, the receiving, decoding and multiplexing of SVD data on 48 optical fibers, the track reconstruction and the definition of the ROIs, will be performed by the presented system. The planned hardware design is based on a distributed set of Advanced Mezzanine Cards (AMC) each equipped with a Field Programmable Gate Array (FPGA) and 4 optical transceivers. In this talk, the status and plans for the DATCON prototype and the FPGA-based tracking algorithm are introduced as well as the plans for their test in the upcoming test beam at DESY.

  4. Mercury(II) ion-selective electrodes based on heterocyclic systems.

    Science.gov (United States)

    Mahajan, Rakesh Kumar; Sood, Pallavi; Pal Mahajan, Mohinder; Marwaha, Alka

    2007-09-01

    Mercury ion-selective electrodes (ISEs) were prepared with a polymeric membrane based on heterocyclic systems: 2-methylsulfanyl-4-(4-nitro-phenyl)-l-p-tolyl-1H-imidazole (I) and 2,4-diphenyl-l-p-tolyl-1H-imidazole (II) as the ionophores. Several ISEs were conditioned and tested for the selection of common ions. The electrodes based on these ionophores showed a good potentiometric response for Hg2+ ions over a wide concentration range of 5.0 x 10(5-) - 1.0 x 10(-1)M with near-Nernstian slopes. Stable potentiometric signals were obtained within a short time period of 20 s. The detection limits, the working pH range of the electrodes were 1.0 x 10(-5) M and 1.6-4.4 respectively. The electrodes showed better selectivity for Hg2+ ions over many of the alkali, alkaline-earth and heavy metal ions. Also sharp end points were obtained when these sensors were used as indicator electrodes for the potentiometric titration of Hg2+ ions with iodide ions.

  5. Data concentrator with FPGA-based track reconstruction for the Belle II DEPFET pixel detector

    Energy Technology Data Exchange (ETDEWEB)

    Schnell, Michael; Dingfelder, Jochen; Marinas, Carlos [Physikalisches Institut, Universitaet Bonn (Germany)

    2013-07-01

    The innermost two layers of the Belle II vertex detector at the KEK facility in Tsukuba, Japan, will be covered by high-granularity DEPFET pixel sensors. The large number of pixels leads to a high data rate of around 60 Gbps, which has to be significantly reduced by the Data Acquisition System. For the data reduction the hit information of the surrounding Silicon strip Vertex Detector (SVD) is utilized to define so-called Regions of Interest (ROI). Only hit information of the pixels located inside these ROIs are saved. The ROIs for the Pixel Detector (PXD) are computed by reconstructing track segments from SVD data and back extrapolation to the PXD. A data reduction of up to a factor of 10 is intended to be achieved by this design. All the necessary processing stages, the receiving and multiplexing of the data from the SVD on 48 optical fibers, the track reconstruction and the definition of the ROIs, will be performed by the Data Concentrator. The planned hardware design is based on a distributed set of Advanced Mezzanine Cards (AMC) each equipped with a Field Programmable Gate Array (FPGA) chip and 4 optical transceivers. In this talk, the hardware and the FPGA-based tracking algorithm is introduced with some preliminary simulation results. In addition, the acquisition and pre-processing of the SVD data are discussed. The presentation concludes with an outlook on a distributed tracking design.

  6. Online data reduction with FPGA-based track reconstruction for the Belle II DEPFET pixel detector

    Energy Technology Data Exchange (ETDEWEB)

    Schnell, Michael; Deschamps, Bruno; Dingfelder, Jochen; Marinas, Carlos [University of Bonn (Germany); Collaboration: Belle II-Collaboration

    2015-07-01

    The innermost two layers of the Belle II vertex detector at the KEK facility in Tsukuba, Japan, will be covered by high-granularity DEPFET pixel sensors (PXD). The large number of pixels leads to a maximum data rate of 256 Gbps, which has to be significantly reduced by the Data Acquisition System. For the data reduction the hit information of the surrounding Silicon strip Vertex Detector (SVD) is utilized to define so-called Regions of Interest (ROI). Only hit information of the pixels located inside these ROIs are saved. The ROIs for the PXD are computed by reconstructing track segments from SVD data and extrapolation to the PXD. The goal is to achieve a data reduction of up to a factor of 10 with this ROI selection. All the necessary processing stages, the receiving, decoding and multiplexing of SVD data on 48 optical fibers, the track reconstruction and the definition of the ROIs, will be performed by the presented system. The planned hardware design is based on a distributed set of Advanced Mezzanine Cards (AMC) each equipped with a Field Programmable Gate Array (FPGA) and 4 optical transceivers. In this talk, the hardware and the FPGA-based tracking algorithm is introduced with some recent performance results from simulation and the latest test beam campaigns.

  7. Zn(II)-dipicolylamine-based metallo-lipids as novel non-viral gene vectors.

    Science.gov (United States)

    Su, Rong-Chuan; Liu, Qiang; Yi, Wen-Jing; Zhao, Zhi-Gang

    2017-08-01

    In this study, a series of Zn(II)-dipicolylamine (Zn-DPA) based cationic lipids bearing different hydrophobic tails (long chains, α-tocopherol, cholesterol or diosgenin) were synthesized. Structure-activity relationship (SAR) of these lipids was studied in detail by investigating the effects of several structural aspects including the type of hydrophobic tails, the chain length and saturation degree. In addition, several assays were used to study their interactions with plasmid DNA, and results reveal that these lipids could condense DNA into nanosized particles with appropriate size and zeta-potentials. MTT-based cell viability assays showed that lipoplexes 5 had low cytotoxicity. The in vitro gene transfection studies showed the hydrophobic tails clearly affected the TE, and hexadecanol-containing lipid 5b gives the best TE, which was 2.2 times higher than bPEI 25k in the presence of 10% serum. The results not only demonstrate that these lipids might be promising non-viral gene vectors, but also afford us clues for further optimization of lipidic gene delivery materials.

  8. A risk-based classification scheme for genetically modified foods. II: Graded testing.

    Science.gov (United States)

    Chao, Eunice; Krewski, Daniel

    2008-12-01

    This paper presents a graded approach to the testing of crop-derived genetically modified (GM) foods based on concern levels in a proposed risk-based classification scheme (RBCS) and currently available testing methods. A graded approach offers the potential for more efficient use of testing resources by focusing less on lower concern GM foods, and more on higher concern foods. In this proposed approach to graded testing, products that are classified as Level I would have met baseline testing requirements that are comparable to what is widely applied to premarket assessment of GM foods at present. In most cases, Level I products would require no further testing, or very limited confirmatory analyses. For products classified as Level II or higher, additional testing would be required, depending on the type of the substance, prior dietary history, estimated exposure level, prior knowledge of toxicity of the substance, and the nature of the concern related to unintended changes in the modified food. Level III testing applies only to the assessment of toxic and antinutritional effects from intended changes and is tailored to the nature of the substance in question. Since appropriate test methods are not currently available for all effects of concern, future research to strengthen the testing of GM foods is discussed.

  9. Spectroscopic, structural and theoretical studies of copper(II) complexes of tridentate NOS Schiff bases

    Science.gov (United States)

    Olalekan, Temitope E.; Ogunlaja, Adeniyi S.; VanBrecht, Bernardus; Watkins, Gareth M.

    2016-10-01

    Two newly synthesized Schiff bases (L4 and L5) were derived from the condensation reaction of 2-(methylthiomethyl)anilines and 4-methoxysalicylaldehyde. Coordination complexes of these and four previously reported NOS Schiff bases, Cu(L1)2-Cu(L6)2, were synthesized via the reflux reaction of the various Schiff base ligands with CuCl2·2H2O. The compounds were characterized by means of elemental analysis, FTIR and UV-Vis. The crystal structures of Cu(L1)2 and Cu(L2)2 were obtained by X-ray diffraction. The Schiff bases were coordinated to copper ion as monobasic tridentate ligands through the phenolic oxygen, azomethine nitrogen and thioether sulfur. The microanalyses of the coordination complexes were agreeable with bimolar binding of the ligands to the copper metal ion. The crystal structures of the copper complexes confirmed an octahedral geometry around the metal centre and showed they are mononuclear. The magnetic moment values indicated the presence of a lone electron in each copper(II) orbital and confirmed the mononuclearity of the complexes. The electronic spectra of the coordination compounds consist of the intraligand, charge transfer and d→d bands. Molecular modeling studies on the complexes (Cu(L1)2-Cu(L6)2) by employing DFT revealed that complex Cu(L5)2 possessed the smallest optimization energy as well as a small HOMO-LUMO energy gap which may best explain its higher polarizability as well as reactivity in comparison to the other complexes.

  10. Validity evidence based on internal structure of scores on the Spanish version of the Self-Description Questionnaire-II.

    Science.gov (United States)

    Ingles, Cándido J; Torregrosa, María S; Hidalgo, María D; Nuñez, Jose C; Castejón, Juan L; García-Fernández, Jose M; Valles, Antonio

    2012-03-01

    The aim of this study was to analyze the reliability and validity evidence of scores on the Spanish version of Self-Description Questionnaire II (SDQ-II). The instrument was administered in a sample of 2022 Spanish students (51.1% boys) from grades 7 to 10. Confirmatory factor analysis (CFA) was used to examine validity evidence based on internal structure drawn from the scores on the SDQ-II. CFA replicated the correlated II first-order factor structure. Furthermore, hierarchical confirmatory factor analysis (HCFA) was used to examine the hierarchical ordering of self-concept, as measured by scores on the Spanish version of the SDQ-II. Although a series of HCFA models were tested to assess academic and non-academic components organization, support for those hierarchical models was weaker than for the correlated 11 first-order factor structure. Results also indicated that scores on the Spanish version of the SDQ-II had internal consistency and test-retest reliability estimates within an acceptable range.

  11. New fluorescent azo-Schiff base Cu(II) and Zn(II) metal chelates; spectral, structural, electrochemical, photoluminescence and computational studies

    Science.gov (United States)

    Purtas, Fatih; Sayin, Koray; Ceyhan, Gokhan; Kose, Muhammet; Kurtoglu, Mukerrem

    2017-06-01

    A new Schiff base containing azo chromophore group obtained by condensation of 2-hydroxy-4-[(E)-phenyldiazenyl]benzaldehyde with 3,4-dimethylaniline (HL) are used for the syntheses of new copper(II) and zinc(II) chelates, [Cu(L)2], and [Zn(L)2], and characterized by physico-chemical and spectroscopic methods such as 1H and 13C NMR, IR, UV.-Vis. and elemental analyses. The solid state structure of the ligand was characterized by single crystal X-ray diffraction study. X-ray diffraction data was then used to calculate the harmonic oscillator model of aromaticity (HOMA) indexes for the rings so as to investigate of enol-imine and keto-amine tautomeric forms in the solid state. The phenol ring C10-C15 shows a considerable deviation from the aromaticity with HOMA value of 0.837 suggesting the shift towards the keto-amine tautomeric form in the solid state. The analytical data show that the metal to ligand ratio in the chelates was found to be 1:2. Theoretical calculations of the possible isomers of the ligand and two metal complexes are performed by using B3LYP method. Electrochemical and photoluminescence properties of the synthesized azo-Schiff bases were also investigated.

  12. Synthesis, Crystal Structure, and Luminescent Properties of New Zinc(II and Cadmium(II Metal-Organic Frameworks Based on Flexible Bis(imidazol-1-ylalkane Ligands

    Directory of Open Access Journals (Sweden)

    Marina Barsukova

    2016-10-01

    Full Text Available New metal-organic frameworks (MOFs based on zinc and cadmium ions, terephthalic acid, and flexible ligands 1,5-bis(imidazol-1-ylpentane or 1,6-bis(imidazol-1-ylhexane were prepared and characterized by X-ray diffraction, thermorgavimetric analysis and IR spectroscopy. The imidazolyl ligands were prepared by a new robust procedure involving the reaction between imidazole and 1,5-dibromopentane or 1,6-dibromohexane in a superbasic medium (KOH in DMSO. MOFs based on 1,5-bis(imidazol-1-ylpentane had diamond topology (dia and are triply interpenetrated. Ligands with longer spacer 1,6-bis(imidazol-1-ylhexane, terephthalate ions and zinc(II ions formed five-fold interpenetrated metal-organic framework also with dia topology, while cadmium(II ions with the same ligands formed eight-connected uninodal net with a very rare self-penetrated topological type ilc and a point symbol 424.5.63. The influence of the chemical composition of MOFs on their photoluminescent properties is investigated and discussed in detail.

  13. A pentanuclear lead(II) complex based on a strapped porphyrin with three different coordination modes.

    Science.gov (United States)

    Le Gac, Stéphane; Furet, Eric; Roisnel, Thierry; Hijazi, Ismail; Halet, Jean-François; Boitrel, Bernard

    2014-10-01

    We have previously described Pb(II) and Bi(III) bimetallic complexes with overhanging carboxylic acid strapped porphyrins in which one metal ion is bound to the N-core ("out-of-plane", OOP), whereas the second one is bound to the strap ("hanging-atop", HAT). In such complexes, the hemidirected coordination sphere of a HAT Pb(II) cation provides sufficient space for an additional binding of a neutral ligand (e.g., DMSO). Interestingly, investigations of the HAT metal coordination mode in a single strap porphyrin show that a HAT Pb(II) can also interact via intermolecular coordination bonds, allowing the self-assembly of two bimetallic complexes. In the pentanuclear Pb(II) complex we are describing in this Article, three different coordination modes were found. The OOP Pb(II) remains inert toward the supramolecular assembling process, whereas the HAT Pb(II) cation, in addition to its intramolecular carboxylate and regular exogenous acetate groups, coordinates an additional exogenous acetate. These two acetates are shared with a third lead(II) cation featuring a holo-directed coordination sphere, from which a centro-symmetric complex is assembled. Density functional theory calculations show some electron-density pockets in the vicinity of the hemidirected HAT Pb(II) atoms, which are associated with the presence of a stereochemically active lone pair of electrons. On the basis of the comparison with other HAT Pb(II) and Bi(III) systems, the "volume" of this lone pair correlates well with the bond distance distributions and the number of the proximal oxygen atoms tethered to the post-transition metal cation. It thus follows the order 6-coordinate Bi(III) > 6-coordinate Pb(II) > 5-coordinate Pb(II).

  14. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. The manganese (II), cobalt (II), nickel (II) and copper (II) complexes of N, N' – ... temperature and coordinated water were determined ... indicating fairly stable complex compounds (Table 1). The complex compounds are insoluble [Table 2] in water and common organic solvents, but are readily soluble in ...

  15. Alginate and Algal-Based Beads for the Sorption of Metal Cations: Cu(II) and Pb(II)

    Science.gov (United States)

    Wang, Shengye; Vincent, Thierry; Faur, Catherine; Guibal, Eric

    2016-01-01

    Alginate and algal-biomass (Laminaria digitata) beads were prepared by homogeneous Ca ionotropic gelation. In addition, glutaraldehyde-crosslinked poly (ethyleneimine) (PEI) was incorporated into algal beads. The three sorbents were characterized by scanning electron microscopy (SEM) coupled with energy dispersive X-ray analysis (EDX): the sorption occurs in the whole mass of the sorbents. Sorption experiments were conducted to evaluate the impact of pH, sorption isotherms, and uptake kinetics. A special attention was paid to the effect of drying (air-drying vs. freeze-drying) on the mass transfer properties. For alginate, freeze drying is required for maintaining the porosity of the hydrogel, while for algal-based sorbents the swelling of the material minimizes the impact of the drying procedure. The maximum sorption capacities observed from experiments were 415, 296 and 218 mg Pb g−1 and 112, 77 and 67 mg Cu g−1 for alginate, algal and algal/PEI beads respectively. Though the sorption capacities of algal-beads decreased slightly (compared to alginate beads), the greener and cheaper one-pot synthesis of algal beads makes this sorbent more competitive for environmental applications. PEI in algal beads decreases the sorption properties in the case of the sorption of metal cations under selected experimental conditions. PMID:27598128

  16. An ICF-CY-Based Content Analysis of the Vineland Adaptive Behavior Scales-II

    Science.gov (United States)

    Gleason, Kara; Coster, Wendy

    2012-01-01

    Background: The International Classification of Functioning, Disability and Health (ICF), and its version for children and youth (ICF-CY), has been increasingly adopted as a system to describe function and disability. A content analysis of the Vineland Adaptive Behavior Scales-II (VABS-II) was conducted to examine congruence with the functioning…

  17. Interband cascade light emitting devices based on type-II quantum wells

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Rui Q.; Lin, C.H.; Murry, S.J. [Univ. of Houston, TX (United States). Space Vacuum Epitaxy Center] [and others

    1997-06-01

    The authors discuss physical processes in the newly developed type-II interband cascade light emitting devices, and review their recent progress in the demonstration of the first type-II interband cascade lasers and the observation of interband cascade electroluminescence up to room temperature in a broad mid-infrared wavelength region (extended to 9 {mu}m).

  18. Effectiveness of team based learning to teach pharmacology for phase-II MBBS students

    Directory of Open Access Journals (Sweden)

    N.K. Hashilkar

    2014-07-01

    Full Text Available Background: TBL (Team based Learning instructional methods foster applying knowledge in a highly interactive setting. Furthermore, in contrast to PBL (Problem Based Learning, it is a teacher directed method that encourages student- student interaction. Objective: The present study is aimed to assess the effectiveness of TBL over the current conventional tutorial type of teaching-learning strategy. Materials and Methods: The present study was conducted in the department of pharmacology of KLE University’s J N Medical College, Belgaum for phase II MBBS students. Students were randomly assigned to either team based learning (TBL or conventional tutorial (CT groups. Teaching learning sessions were conducted on similar topics of cardiovascular system following mechanics of TBL or tutorials respectfully. Effectiveness of each session was assessed by common pre-test and post test while, the overall performance was assessed at the end by a common test for both groups. The scores of the two groups were analysed using students t-test. A feedback was obtained from the students regarding their experience with TBL. Results: There was a significant difference between the pre-CT and pre-TBL scores for Anti-hypertensives (p ≤ 0.0001 and congestive cardiac failure (p ≤0.0002 sessions while these scores were not significantly different for Anti-anginals and Renin angiotensin system. However, the comparison of post-CT and post-TBL scores were significantly different (p< 0.05 for each of the four sessions. The scores of the end of the module test showed significant difference (p <0.0001 between the two group. Most of the students appreciated the mechanics of TBL and were satisfied with it. Conclusions: The performance of the students of the TBL group improved in individual sessions as well as the entire module as opposed to the CT group.

  19. Some new nano-sized Fe(II), Cd(II) and Zn(II) Schiff base complexes as precursor for metal oxides: Sonochemical synthesis, characterization, DNA interaction, in vitro antimicrobial and anticancer activities.

    Science.gov (United States)

    Abdel-Rahman, Laila H; Abu-Dief, Ahmed M; El-Khatib, Rafat M; Abdel-Fatah, Shimaa Mahdy

    2016-12-01

    The complexes of Fe(II), Cd(II) and Zn(II) with Schiff base derived from 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared. Melting points, decomposition temperatures, Elemental analyses, TGA, conductance measurements, infrared (IR) and UV-Visible spectrophotometric studies were utilized in characterizing the compounds. The UV-Visible spectrophotometric analysis revealed 1:1 (metal-ligand) stoichiometry for the three complexes. In addition to, the prepared complexes have been used as precursors for preparing their corresponding metal oxides nanoparticles via thermal decomposition. The structures of the nano-sized complexes and their metal oxides were characterized by X-ray powder diffraction and transmittance electron microscopy. Moreover, the prepared Schiff base ligand, its complexes and their corresponding nano-sized metal oxides have been screened in vitro for their antibacterial activity against three bacteria, gram-positive (Microccus luteus) and gram-negative (Escherichia coli, Serratia marcescence) and three strains of fungus. The metal chelates were shown to possess more antimicrobial activity than the free Schiff-base chelate and their nano-sized metal oxides have the highest activity. The binding behaviors of the complexes to calf thymus DNA have been investigated by absorption spectra, viscosity mensuration and gel electrophoresis. The DNA binding constants reveal that all these complexes interact with DNA through intercalative binding mode. Furthermore, the cytotoxic activity of the prepared Schiff base complexes on human colon carcinoma cells, (HCT-116 cell line) and hepatic cellular carcinoma cells, (HepG-2) showed potent cytotoxicity effect against growth of carcinoma cells compared to the clinically used Vinblastine standard. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Binding selectivity of vitamin K3 based chemosensors towards nickel(II) and copper(II) metal ions

    Science.gov (United States)

    Patil, Amit; Lande, Dipali N.; Nalkar, Archana; Gejji, Shridhar P.; Chakrovorty, Debamitra; Gonnade, Rajesh; Moniz, Tânia; Rangel, Maria; Pereira, Eulália; Salunke-Gawali, Sunita

    2017-09-01

    The vitamin K3 derivatives 2-methyl-3-[(pyridin-2-ylmethyl)-amino]-1,4-naphthoquinone (M-1), 2-methyl-3-[(pyridin-2-ylethyl)-amino]-1,4-naphthoquinone (M-2), 2-methyl-3-((2-(thiophen-2-yl)methyl)amino)naphthalene-1,4-dione (M-3) and 2-methyl-3-((2-(thiophen-2-yl)ethyl)amino)naphthalene-1,4-dione (M-4) have been synthesized, characterized and studied for their chemosensor abilities towards transition metal ions. Crystal structures of M-1 to M-4 revealed a variety of Nsbnd H⋯O, Csbnd H⋯O, Csbnd H⋯π and π⋯π interactions. Minor variations in such interactions by chemical stimuli such as metal ions, results in change in color that can be visualized by naked eyes. It has been shown that electronic structure and 1H NMR, vibrational as well as electronic spectra from the density functional theory agree well with the experiments. The metal ion binding in ethanol, ethanol-water and in mild base triethylamine brings forth recognizing ability of M-1 toward Ni2+ whereas M-2 exhibits large sensing ability for Cu2+ ion. Interestingly M-1 display varying metal ion binding specificity in different solvents with the association constant in ethanol being 11,786 M-1 for Ni2+ compared to 9462 M-1 for the Cu2+. A reversal in preferential binding of M-2 with the respective association constants being 4190 M-1 and 6370 M-1 is discernible.

  1. Synthesis of Quercetin Loaded Nanoparticles Based on Alginate for Pb(II) Adsorption in Aqueous Solution

    Science.gov (United States)

    Qi, Yun; Jiang, Meng; Cui, Yuan-Lu; Zhao, Lin; Zhou, Xia

    2015-10-01

    Pb(II) is a representative heavy metal in industrial wastewater, which may frequently cause serious hazard to living organisms. In this study, comparative studies between alginate nanoparticles (AN) and quercetin-decorated alginate nanoparticles (Q-AN) were investigated for Pb(II) ion adsorption. Characterization of AN and Q-AN were analysed by transmission electron microscopy (TEM), Fourier transform infrared spectrometry (FT-IR), X-ray diffractometer (XRD), and thermogravimetric analysis (TG-DTG-DSC). The main operating conditions such as pH, initial concentration of Pb(II), and co-existing metal ions were also investigated using a batch experiment. AN and Q-AN, with a diameter of 95.06 and 58.23 nm, were constituted by many small primary nanoparticles. It revealed that when initial concentration of Pb(II) is between 250 and 1250 mg L-1, the adsorption rate and equilibrium adsorption were increased with the increase of pH from 2 to 7. The maximum adsorption capacities of 147.02 and 140.37 mg L-1 were achieved by AN and Q-AN, respectively, with 0.2 g adsorbents in 1000 mg L-1 Pb(II) at pH 7. The adsorption rate of Pb(II) was little influenced by the co-existing metal ions, such as Mn(II), Co(II), and Cd(II). Desorption experiments showed that Q-AN possessed a higher desorption rate than AN, which were 90.07 and 83.26 %, respectively. AN and Q-AN would probably be applied as adsorbents to remove Pb(II) and then recover it from wastewater for the advantages of simple preparation, high adsorption capacity, and recyclability.

  2. Tentative assignment of the potato serine protease inhibitor group as ß-II proteins based on their spectroscopic characteristics.

    NARCIS (Netherlands)

    Pouvreau, L.A.M.; Gruppen, H.; Koningsveld, van G.A.; Broek, van den L.A.M.; Voragen, A.G.J.

    2004-01-01

    Potato serine protease inhibitor (PSPI) is the most abundant protease inhibitor group in potato tuber. The investigated PSPI isoforms have a highly similar structure at both the secondary and the tertiary level. From the results described, PSPI is classified as a ß-II protein based on (1) the

  3. Doorways II: Community Counselor Reference Materials. On School-Related Gender-Based Violence Prevention and Response

    Science.gov (United States)

    US Agency for International Development, 2009

    2009-01-01

    The Doorways training program was designed by the U.S. Agency for International Development (USAID)-funded Safe Schools Program (Safe Schools) to enable teachers, community members and students to prevent and respond to school-related gender-based violence (SRGBV). This booklet, "Doorways II: Community Counselor Reference Materials on…

  4. Doorways II: Community Counselor Training Manual on School-Related Gender-Based Violence Prevention and Response

    Science.gov (United States)

    US Agency for International Development, 2009

    2009-01-01

    The Doorways training program was designed by the U.S. Agency for International Development (USAID)-funded Safe Schools Program (Safe Schools) to enable teachers, community members and students to prevent and respond to school-related gender-based violence (SRGBV). Doorways II was designed for community counselors to prevent and respond to…

  5. Acceptance and Commitment Based Therapy on Disease Perception and Psychological Capital in Patients with Type II Diabetes

    Directory of Open Access Journals (Sweden)

    A. Baghban Baghestan

    2017-02-01

    Full Text Available Aims: As a prevalent metabolic disease, diabetes can be followed by severe mental outcomes leading to problems affecting the daily life. The aim of the study was to determine the effects of acceptance and commitment-based intervention on illness perception and psychological capital in persons with type II diabetes. Materials & Methods: In the controlled pretest-posttest semi-experimental study, 34 patients with type II diabetes were studied in the Diabetes Clinic of Chamran Hospital of Ferdows City in 2015. The subjects, selected via available sampling method, were randomly divided into two groups including control (n=17 persons and experimental (n=17 persons groups. Data was collected by short illness perception questionnaire (IPQ and Luthans’ psychological capital questionnaire (PCQ. Eight 60-minute acceptance and commitment-base intervention sessions were weekly conducted in experimental group. Data was analyzed by SPSS 18 software using descriptive statistics and covariance analysis test. Findings: The pretest score having been adjusted, the acceptance and commitment-based intervention significantly increases the scores of illness perception and its sub-scales (p=0.0001 except the personal control sub-scale. In addition, it significantly increases the scores of the psychological capital and its sub-scales (p=0.0001 in patients with type II diabetes. Conclusion: The acceptance and commitment-based intervention can considerably improve the illness perception and the psychological capital in persons with type II diabetes.

  6. Interview-based Qualitative Research in Emergency Care Part II: Data Collection, Analysis and Results Reporting.

    Science.gov (United States)

    Ranney, Megan L; Meisel, Zachary F; Choo, Esther K; Garro, Aris C; Sasson, Comilla; Morrow Guthrie, Kate

    2015-09-01

    Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. In Part I of this two-article series, we provided an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field (observation, individual interviews, and focus groups). Here in Part II of this series, we outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research.

  7. Proper Motion of the Leo II Dwarf Galaxy Based On Hubble Space Telescope Imaging

    CERN Document Server

    Piatek, Slawomir; Olszewski, Edward W

    2016-01-01

    This article reports a measurement of the proper motion of Leo II, a dwarf galaxy that is a likely satellite of the Milky Way, based on imaging with the Hubble Space Telescope and Wide Field Camera 3. The measurement uses compact background galaxies as standards of rest in both channels of the camera for two distinct pointings of the telescope and a QSO in one channel for each pointing, resulting in the weighted average of six measurements. The measured proper motion in the the equatorial coordinate system is (mu_alpha, mu_delta) = (-6.9 +- 3.7, -8.7 +- 3.9) mas/century and in the Galactic coordinate system is (mu_l, mu_b) = (6.2 +- 3.9, -9.2 +- 3.7) mas/century. The implied space velocity with respect to the Galactic center is (Pi, Theta, Z) = (-37 +- 38, 117 +- 43, 40 +- 16) km/s or, expressed in Galactocentric radial and tangential components, (V_r, V_tan) = (21.9 +- 1.5, 127 +- 42) km/s. The space velocity implies that the instantaneous orbital inclination is 68 degrees, with a 95% confidence interval of ...

  8. Production of Recombinant Trichoderma reesei Cellobiohydrolase II in a New Expression System Based on Wickerhamomyces anomalus

    Directory of Open Access Journals (Sweden)

    Dennis J. Díaz-Rincón

    2017-01-01

    Full Text Available Cellulase is a family of at least three groups of enzymes that participate in the sequential hydrolysis of cellulose. Recombinant expression of cellulases might allow reducing their production times and increasing the low proteins concentrations obtained with filamentous fungi. In this study, we describe the production of Trichoderma reesei cellobiohydrolase II (CBHII in a native strain of Wickerhamomyces anomalus. Recombinant CBHII was expressed in W. anomalus 54-A reaching enzyme activity values of up to 14.5 U L−1. The enzyme extract showed optimum pH and temperature of 5.0–6.0 and 40°C, respectively. Enzyme kinetic parameters (KM of 2.73 mM and Vmax of 23.1 µM min−1 were between the ranges of values reported for other CBHII enzymes. Finally, the results showed that an enzymatic extract of W. anomalus 54-A carrying the recombinant T. reesei CBHII allows production of reducing sugars similar to that of a crude extract from cellulolytic fungi. These results show the first report on the use of W. anomalus as a host to produce recombinant proteins. In addition, recombinant T. reesei CBHII enzyme could potentially be used in the degradation of lignocellulosic residues to produce bioethanol, based on its pH and temperature activity profile.

  9. Map based multimedia tool on Pacific theatre in World War II

    Science.gov (United States)

    Pakala Venkata, Devi Prasada Reddy

    Maps have been used for depicting data of all kinds in the educational community for many years. A standout amongst the rapidly changing methods of teaching is through the development of interactive and dynamic maps. The emphasis of the thesis is to develop an intuitive map based multimedia tool, which provides a timeline of battles and events in the Pacific theatre of World War II. The tool contains summaries of major battles and commanders and has multimedia content embedded in it. The primary advantage of this Map tool is that one can quickly know about all the battles and campaigns of the Pacific Theatre by accessing Timeline of Battles in each region or Individual Battles in each region or Summary of each Battle in an interactive way. This tool can be accessed via any standard web browser and motivate the user to know more about the battles involved in the Pacific Theatre. It was made responsive using Google maps API, JavaScript, HTML5 and CSS.

  10. Interview-Based Qualitative Research in Emergency Care Part II: Data Collection, Analysis and Results Reporting

    Science.gov (United States)

    Ranney, Megan L.; Meisel, Zachary; Choo, Esther K.; Garro, Aris; Sasson, Comilla; Morrow, Kathleen

    2015-01-01

    Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. In Part I of this two-article series, we provided an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field (observation, individual interviews, and focus groups). Here in Part II of this series, we outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research. PMID:26284572

  11. Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes.

    Directory of Open Access Journals (Sweden)

    Carola Engler

    Full Text Available We have developed a protocol to assemble in one step and one tube at least nine separate DNA fragments together into an acceptor vector, with 90% of recombinant clones obtained containing the desired construct. This protocol is based on the use of type IIs restriction enzymes and is performed by simply subjecting a mix of 10 undigested input plasmids (nine insert plasmids and the acceptor vector to a restriction-ligation and transforming the resulting mix in competent cells. The efficiency of this protocol allows generating libraries of recombinant genes by combining in one reaction several fragment sets prepared from different parental templates. As an example, we have applied this strategy for shuffling of trypsinogen from three parental templates (bovine cationic trypsinogen, bovine anionic trypsinogen and human cationic trypsinogen each divided in 9 separate modules. We show that one round of shuffling using the 27 trypsinogen entry plasmids can easily produce the 19,683 different possible combinations in one single restriction-ligation and that expression screening of a subset of the library allows identification of variants that can lead to higher expression levels of trypsin activity. This protocol, that we call 'Golden Gate shuffling', is robust, simple and efficient, can be performed with templates that have no homology, and can be combined with other shuffling protocols in order to introduce any variation in any part of a given gene.

  12. A kinetic study of copper(II) oxide powder reduction with hydrogen, based on thermogravimetry

    Energy Technology Data Exchange (ETDEWEB)

    Jelic, Dijana [Faculty of Medicine, Departmet of Pharmacy - Chair of Physical Chemistry, University of Banja Luka, Banja Luka, Bosnia and Herzegovina (Bosnia and Herzegowina); Tomic-Tucakovic, Biljana [Institute of General and Physical Chemistry, Studentski trg 12, 11158 Belgrade (Serbia); Mentus, Slavko, E-mail: slavko@ffh.bg.ac.rs [University of Belgrade, Faculty of Physical Chemistry, Studentski trg 12, 11185 Belgrade (Serbia)

    2011-07-10

    Highlights: {yields} The reduction of CuO by hydrogen was studied by thermogravimetry. {yields} The particle size of the samples varied inside the submicron range. {yields} The experimental data were fitted by means of a nucleation-growth model. {yields} The particle size influenced the kinetic parameters but not the reaction model. - Abstract: The reduction of powdery copper(II) oxide was carried out in a stream of gaseous mixture 25% H{sub 2} + Ar, and followed by thermogravimetry. The two samples of different history were studied: the commercial one, and that synthesized by citrate gel combustion method. The characterization of the starting materials, based on X-ray diffractometry and scanning electron microscopy, indicated equal crystal structure, but different particle size and morphology. The particle size and shape of the metallic particles obtained upon the reduction were observed by means of electron microscope. By a nonlinear regression analysis by means of a software Kinetics05, the experimental data were fitted with the nucleation-growth kinetic model, and the corresponding kinetic parameters were determined.

  13. Electrochemical sensor based on polystyrene sulfonate-carbon nanopowders composite for Cu (II) determination.

    Science.gov (United States)

    Cantalapiedra, Alberto; Gismera, M Jesús; Procopio, Jesús R; Sevilla, M Teresa

    2015-07-01

    A differential pulse anodic stripping voltammetric (DPASV) method, with an open circuit (OC) approach in the pre-concentration step has been developed for copper ion determination at very low concentration level using a sensor based on a polystyrene sulfonate-carbon nanopowders (PSS-CnP) composite. This composite material is easily prepared from ultrasonic assisted dispersions of CnP in aqueous solution of PSS. For preparation of sensor devices, a reproducible and inexpensive drop coating procedure of the surface of home-made pencil graphite electrodes (PGEs) using a CnP dispersion in PSS was performed. At the optimal conditions for accumulation (0.01molL(-1) KNO3 at pH 3) and measurement steps (a reduction potential of -0.5V for 60s and then, an anodic DPV scan) and using a pre-concentration time of 300s, the limit of detection was 0.11µgL(-1) (1.73nM). This OC-DPASV method using the PSS-CnP-PGE sensor was successfully employed for Cu(II) determination in mineral, river and sea water samples.

  14. Photocytotoxic ternary copper(II) complexes of histamine Schiff base and pyridyl ligands

    Indian Academy of Sciences (India)

    Samya Banerjee; Akanksha Dixit; K Sesha Maheswaramma; Basudev Maity; Sanjoy Mukherjee; Arun Kumar; Anjali A Karande; Akhil R Chakravarty

    2016-02-01

    Ternary copper(II) complexes of salicylaldehyde-histamine Schiff base (HL) and pyridyl ligands, viz. [Cu(bpy)(L)](ClO4) (1) and [Cu(dppz)(L)](ClO4) (2), where bpy is 2,2′-bipyridine (in 1) and dppz is dipyrido[3,2-a:2′,3′-c]phenazine (in 2), were synthesized, characterized and their DNA binding, photo-activated DNA cleavage activity and photocytotoxicity studied. The 1:1 electrolytic one-electron paramagnetic complexes showed a d-d band near 670 nm in aqueous DMF (1:1 v/v). The crystal structure of complex 1 showed the metal in CuN4O distorted square-pyramidal geometry. Complex 2 intercalatively binds to calf-thymus (ct) DNA with a binding constant (b) of ∼105 M−1. It exhibited moderate chemical nuclease activity but excellent DNA photocleavage activity in red light of 647 nm forming $^{\\bullet}\\text{OH}$ radicals. It showed remarkable photocytotoxicity in human cervical cancer cells (HeLa) giving IC50 of 1.6 M in visible light (400-700 nm) with low dark toxicity. The photo-induced cell death is via generation of oxidative stress by reactive oxygen species.

  15. A New Composition for Co(II-porphyrin-based Membranes Used in Thiocyanate-selective Electrodes

    Directory of Open Access Journals (Sweden)

    Otilia Bizerea-Spiridon

    2006-08-01

    Full Text Available In the present paper, the potentiometric response characteristics of ametalloporphyrin-based electrode in o-nitrophenyloctylether (o-NPOE plasticizedpolyvinyl chloride (PVC membrane are presented for a set of monovalent anions. Asmembrane ionophore, 5,10,15,20-tetrakis-(4-methoxyphenyl-porphyrin-Co(II(CoTMeOPP was used. To establish the optimum composition of the membrane, differentmolar percents of cationic derivative (mol.% relative to ionophore were used. Electrodesformulated with membranes containing 1 wt.% ionophore, 66 wt.% o-NPOE, 33 wt.% PVC(plasticizer: PVC = 2:1 and the lipophilic cationic derivative (35 mol% are shown toexhibit high selectivity for thiocyanate with a near-Nernstian slope in the workingconcentration range of 1.0×10−1–1.0×10−5 M, with a good stability in time.

  16. Damage Detection Technique for Cold-Formed Steel Beam Structure Based on NSGA-II

    Directory of Open Access Journals (Sweden)

    Byung Kwan Oh

    2015-01-01

    Full Text Available Cold-formed steel is uniform in quality, suitable for mass production, and light in weight. It is widely used for both structural and nonstructural members in buildings. When it is used in a bending structural member, damage such as local buckling is considered to be more important than general steel members in terms of failure mode. However, preceding studies on damage detection did not consider the failure characteristics of cold-formed beam members. Hence, this paper proposes a damage detection technique that considers the failure mode of local buckling for a cold-formed beam member. The differences between the dynamic characteristics from vibration-based measurements and those from finite element model are set to error functions. The error functions are minimized by the optimization technique NSGA-II. In the damage detection, the location of local damage and the severity of damage are considered variables. The proposed technique was validated through a simulation of damage detection for a cold-formed steel beam structure example.

  17. Electrochemical Studies of Betti Base and Its Copper(II Complex by Cyclic and Elimination Voltammetry

    Directory of Open Access Journals (Sweden)

    Shardul Bhatt

    2013-01-01

    Full Text Available The electrochemical behavior of Betti base 1-(α-amino benzyl-2-naphthol (BB and its copper(II complex by cyclic and elimination voltammetry (EVLS is reported in the present study. The cyclic voltammetric studies carried out at a glassy carbon working electrode, Ag/Ag+ reference electrode (0.01 M AgNO3 in acetonitrile in DCM at 100 mV/sec, 200 mV/sec, and 400 mV/sec scan rates indicated a preceding chemical oxidation of the adsorbed BB species to form an iminium ion followed by formation of a carbanion via two-step quasireversible reduction. The suggested reaction mechanism has been supported by the elimination voltammetry. The CV and EVLS studies revealed Cu(IIBB complex to undergo a chemical or a surface reaction before electron transfer from the electrode at −0.49 V to form Cu(IBB species. The oxidation of Cu(IBB species has been observed to be CV silent.

  18. NH-type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications.

    Science.gov (United States)

    Bergagnini, Mackenzie; Fukushi, Kazunobu; Han, Jianlin; Shibata, Norio; Roussel, Christian; Ellis, Trevor K; Aceña, José Luis; Soloshonok, Vadim A

    2014-02-28

    The work being reported here deals with the design of a new type of "N-H" Ni(II) complexes of glycine Schiff bases and study general aspects of their reactivity. It was confirmed that the presence of NH function in these Ni(II) complexes does not interfere with the homologation of the glycine residue, rendering these derivatives of high synthetic value for the general synthesis of α-amino acids. In particular, the practical application of these NH-type complexes was demonstrated by asymmetric synthesis of various β-substituted pyroglutamic acids via Michael addition reactions with chiral Michael acceptors.

  19. Spectroscopic investigation into the interaction of a diazacyclam-based macrocyclic copper(ii) complex with bovine serum albumin.

    Science.gov (United States)

    Shahabadi, Nahid; Hakimi, Mohammad; Morovati, Teimoor; Hadidi, Saba; Moeini, Keyvan

    2017-02-01

    Cyclam-based ligands and their complexes are known to show antitumor activity. This study was undertaken to examine the interaction of a diazacyclam-based macrocyclic copper(II) complex with bovine serum albumin (BSA) under physiological conditions. The interactions of different metal-based drugs with blood proteins, especially those with serum albumin, may affect the concentration and deactivation of metal drugs, and thereby influence their availability and toxicity during chemotherapy. In this vein, several spectral methods including UV-vis absorption, fluorescence and circular dichroism (CD) spectroscopy techniques were used. Spectroscopic analysis of the fluorescence quenching confirmed that the Cu(II) complex quenched BSA fluorescence intensity by a dynamic mechanism. In order to further determine the quenching mechanism, an analysis of Stern-Volmer plots at various concentrations of BSA was carried out. It was found that the KSV value increased with the BSA concentration. It was suggested that the fluorescence quenching process was a dynamic quenching rather than a static quenching mechanism. Based on Förster's theory, the average binding distance between the Cu(II) complex and BSA (r) was found to be 4.98 nm; as the binding distance was less than 8 nm, energy transfer from BSA to the Cu(II) complex had a high possibility of occurrence. Thermodynamic parameters (positive ΔH and ΔS values) and measurement of competitive fluorescence with 1-anilinonaphthalene-8-sulphonic acid (1,8-ANS) indicated that hydrophobic interaction plays a major role in the Cu(II) complex interaction with BSA. A Job's plot of the results confirmed that there was one binding site in BSA for the Cu(II) complex (1:1 stoichiometry). The site marker competitive experiment confirmed that the Cu(II) complex was located in site I (subdomain IIA) of BSA. Finally, CD data indicated that interaction of the Cu(II) complex with BSA caused a small increase in the α-helical content. Copyright

  20. Synthesis, Spectroscopy, Thermal Analysis, Magnetic Properties and Biological Activity Studies of Cu(II and Co(II Complexes with Schiff Base Dye Ligands

    Directory of Open Access Journals (Sweden)

    Saeid Amani

    2012-05-01

    Full Text Available Three azo group-containing Schiff base ligands, namely 1-{3-[(3-hydroxy-propyliminomethyl]-4-hydroxyphenylazo}-4-nitrobenzene (2a, 1-{3-[(3-hydroxypropyl-iminomethyl]-4-hydroxyphenylazo}-2-chloro-4-nitrobenzene (2b and 1-{3-[(3-hydroxy-propyliminomethyl]-4-hydroxyphenylazo}-4-chloro-3-nitrobenzene (2c were prepared. The ligands were characterized by elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, 13C- and 1H-NMR spectroscopy and thermogravimetric analysis. Next the corresponding copper(II and cobalt(II metal complexes were synthesized and characterized by the physicochemical and spectroscopic methods of elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, magnetic moment measurements, and thermogravimetric analysis (TGA and (DSC. The room temperature effective magnetic moments of complexes are 1.45, 1.56, 1.62, 2.16, 2.26 and 2.80 B.M. for complexes 3a, 3b, 3c, 4a 4b, and 4c, respectively, indicating that the complexes are paramagnetic with considerable electronic communication between the two metal centers.

  1. Synthesis and synergistic antifungal activities of a pyrazoline based ligand and its copper(II) and nickel(II) complexes with conventional antifungals.

    Science.gov (United States)

    Ali, Imran; Wani, Waseem A; Khan, Amber; Haque, Ashanul; Ahmad, Aijaz; Saleem, Kishwar; Manzoor, Nikhat

    2012-08-01

    A pyrazoline based ligand; (5-(4-chlorophenyl)-3-phenyl-4, 5-dihydro-1H-pyrazole-1-carbothioamide) has been synthesized by Claisen-Schmidt condensation of acetophenone with p-chlorobenzaldehyde, followed by sodium hydroxide assisted cyclization of the resulting chalcone with thiosemicarbazide. Metal ion complexes of the synthesized ligand were prepared with Cu(II) and Ni(II) metal ions, separately and respectively. Ligand and the metal complexes were characterized by elemental analysis, FT-IR, UV-Vis, (1)HNMR, ESI-MS and (13)CNMR spectroscopic techniques. Molar conductance measurements in DMSO suggested non-electrolytic nature of the complexes. Tetragonally distorted octahedral geometry for copper and octahedral geometry for the nickel complexes was proposed on the basis of UV-Vis spectroscopic studies and magnetic moment measurements. The complexes were investigated for their ability to kill human fungal pathogen Candida by determining MICs (Minimum inhibitory concentrations), inhibition in solid media and ability to produce a possible synergism with conventional most clinically practiced antifungals by disc diffusion assay and FICI (fractional inhibitory concentration index).

  2. Synthesis, spectroscopy, thermal analysis, magnetic properties and biological activity studies of Cu(II) and Co(II) complexes with Schiff base dye ligands.

    Science.gov (United States)

    Ahmadi, Raziyeh Arab; Amani, Saeid

    2012-05-29

    Three azo group-containing Schiff base ligands, namely 1-{3-[(3-hydroxypropylimino) methyl]-4-hydroxyphenylazo}-4-nitrobenzene (2a), 1-{3-[(3-hydroxypropylimino) methyl]-4-hydroxyphenylazo}-2-chloro-4-nitrobenzene (2b) and 1-{3-[(3-hydroxypropylimino) methyl]-4-hydroxyphenylazo}-4-chloro-3-nitrobenzene (2c) were prepared. The ligands were characterized by elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, ¹³C- and ¹H-NMR spectroscopy and thermogravimetric analysis. Next the corresponding copper(II) and cobalt(II) metal complexes were synthesized and characterized by the physicochemical and spectroscopic methods of elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, magnetic moment measurements, and thermogravimetric analysis (TGA) and (DSC). The room temperature effective magnetic moments of complexes are 1.45, 1.56, 1.62, 2.16, 2.26 and 2.80 B.M. for complexes 3a, 3b, 3c, 4a 4b, and 4c, respectively, indicating that the complexes are paramagnetic with considerable electronic communication between the two metal centers.

  3. Multi-crystalline II-VI based multijunction solar cells and modules

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Brian E.; Connor, Stephen T.; Groves, James R.; Peters, Craig H.

    2015-06-30

    Multi-crystalline group II-VI solar cells and methods for fabrication of same are disclosed herein. A multi-crystalline group II-VI solar cell includes a first photovoltaic sub-cell comprising silicon, a tunnel junction, and a multi-crystalline second photovoltaic sub-cell. A plurality of the multi-crystalline group II-VI solar cells can be interconnected to form low cost, high throughput flat panel, low light concentration, and/or medium light concentration photovoltaic modules or devices.

  4. Determination of copper(II) in the dairy product by an electrochemical sensor based on click chemistry.

    Science.gov (United States)

    Qiu, Suyan; Xie, Lidan; Gao, Sen; Liu, Qida; Lin, Zhenyu; Qiu, Bin; Chen, Guonan

    2011-11-30

    Herein, a novel sensitive electrochemical sensor for copper(II) based on Cu(I) catalyzed alkyne-azide cycloaddition reaction (CuAAC) is described. The catalyst of Cu(I) species is derived from electrochemical reduction of Cu(II) through bulk electrolysis (BE) with coulometry technique. The propargyl-functionalized ferrocene (propargyl-functionalized Fc) is covalently coupled onto the electrode surface via CuAAC reaction and forms propargyl-functionalized Fc modified gold electrode, which allows a good and stable electrochemical signal. The change of current at peak (dI), detected by differential pulse voltammetry (DPV), exhibits a linear response to the logarithm of Cu(II) concentration in the range of 1.0×10(-14)-1.0×10(-9) mol L(-1). It is also found that the proposed sensor has a good selectivity for copper(II) assay even in the presence of other common metal ions. Additionally, the proposed method has been applied to determine copper(II) in the dairy product (yoghurt) with satisfactory results.

  5. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction

    Directory of Open Access Journals (Sweden)

    Lund Ole

    2009-09-01

    Full Text Available Abstract Background The major histocompatibility complex (MHC molecule plays a central role in controlling the adaptive immune response to infections. MHC class I molecules present peptides derived from intracellular proteins to cytotoxic T cells, whereas MHC class II molecules stimulate cellular and humoral immunity through presentation of extracellularly derived peptides to helper T cells. Identification of which peptides will bind a given MHC molecule is thus of great importance for the understanding of host-pathogen interactions, and large efforts have been placed in developing algorithms capable of predicting this binding event. Results Here, we present a novel artificial neural network-based method, NN-align that allows for simultaneous identification of the MHC class II binding core and binding affinity. NN-align is trained using a novel training algorithm that allows for correction of bias in the training data due to redundant binding core representation. Incorporation of information about the residues flanking the peptide-binding core is shown to significantly improve the prediction accuracy. The method is evaluated on a large-scale benchmark consisting of six independent data sets covering 14 human MHC class II alleles, and is demonstrated to outperform other state-of-the-art MHC class II prediction methods. Conclusion The NN-align method is competitive with the state-of-the-art MHC class II peptide binding prediction algorithms. The method is publicly available at http://www.cbs.dtu.dk/services/NetMHCII-2.0.

  6. Sensitive detection of biothiols and histidine based on the recovered fluorescence of the carbon quantum dots–Hg(II) system

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Juan; Zhang, Fengshuang; Yan, Xu; Wang, Long; Yan, Jin [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Ding, Hong [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Ding, Lan, E-mail: dinglan@jlu.edu.cn [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China)

    2015-02-15

    Highlights: • Carbon quantum dots-based probe was used for detection of GSH, Cys or His. • The fluorescence of CQDs was quenched by Hg(II) and then recovered by GSH, Cys or His. • No further surface modification or purification of CQDs was required. • This sensor exhibits superior accuracy and sensitivity. • The proposed method was simple in design, fast in operation. - Abstract: In this paper, we presented a novel, rapid and highly sensitive sensor for glutathione (GSH), cysteine (Cys) and histidine (His) based on the recovered fluorescence of the carbon quantum dots (CQDs)–Hg(II) system. The CQDs were synthesized by microwave-assisted approach in one pot according to our previous report. The fluorescence of CQDs could be quenched in the presence of Hg(II) due to the coordination occurring between Hg(II) and functional groups on the surface of CQDs. Subsequently, the fluorescence of the CQDs–Hg(II) system was recovered gradually with the addition of GSH, Cys or His due to their stronger affinity with Hg(II). A good linear relationship was obtained from 0.10 to 20 μmol L{sup −1} for GSH, from 0.20 to 45 μmol L{sup −1} for Cys and from 0.50 to 60 μmol L{sup −1} for His, respectively. This method has been successfully applied to the trace detection of GSH, Cys or His in human serum samples with satisfactory results. The proposed method was simple in design and fast in operation, which demonstrated great potential in bio-sensing fields.

  7. Sol-gel based optical sensor for determination of Fe (II): a novel probe for iron speciation.

    Science.gov (United States)

    Samadi-Maybodi, Abdolraouf; Rezaei, Vida; Rastegarzadeh, Saadat

    2015-02-05

    A highly selective optical sensor for Fe (II) ions was developed based on entrapment of a sensitive reagent, 2,4,6-tri(2-pyridyl)-s-triazine (TPTZ), in a silica sol-gel thin film coated on a glass substrate. The thin films fabricated based on tetraethoxysilane (TEOS) as precursor, sol-gel pH∼3, water:alkoxyde ratio of 4:1 and TPTZ concentration of 0.112 mol L(-1). The influence of sol-gel parameters on sensing behavior of the fabricated sensor was also investigated. The fabricated sensor can be used for determination of Fe (II) ion with an outstanding high selectivity over a dynamic range of 5-115 ng mL(-1) and a detection limit of 1.68 ng mL(-1). It also showed reproducible results with relative standard deviation of 3.5% and 1.27% for 10 and 90 ng mL(-1) of Fe (II), respectively, along with a fast response time of ∼120 s. Total iron also was determined after reduction of Fe (III) to Fe (II) using ascorbic acid as reducing agent. Then, the concentration of Fe (III) was calculated by subtracting the concentration of Fe (II) from the total iron concentration. Interference studies showed a good selectivity for Fe (II) with trapping TPTZ into sol-gel matrix and appropriately adjusting the structure of doped sol-gel. The sensor was compared with other sensors and was applied to determine iron in different water samples with good results.

  8. and Ni (II) complexes with Schiff base derived from 2-amino benzoic ...

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    However, manganese(II) complex is insoluble in most organic solvents but ... The chemical analysis data showed the formation of (1:1) metal - ligand ration and a square planar ... were done on a Pye Unicam UV-visible spectrophotometer.

  9. A low cost matching motion estimation sensor based on the NIOS II microprocessor

    National Research Council Canada - National Science Library

    González, Diego; Botella, Guillermo; Meyer-Baese, Uwe; García, Carlos; Sanz, Concepción; Prieto-Matías, Manuel; Tirado, Francisco

    2012-01-01

    ...) and NIOS II microprocessor applying a C to Hardware (C2H) acceleration paradigm. The design, which involves several matching algorithms, is mapped using Very Large Scale Integration (VLSI) technology...

  10. Studies in transition metal chemistry ; VI. Soluble Ziegler-type catalysts based on vanadium, part II

    NARCIS (Netherlands)

    Liefde Meijer, H.J. de; Hurk, J.W.G. van den; Kerk, G.J.M. van der

    1966-01-01

    Spectrophotometric measurements in the visible region on soluble catalyst systems prepared from (i) vanadium tetrachloride, aluminium bromide and tetraphenyltin and (ii) vanadium tetrachloride or vanadium oxytrichloride and ethylaluminium dihalides are reported. The formation of hydrocarbonsoluble i

  11. Synthesis, characterization and DNA cleavage activity of nickel(II adducts with aromatic heterocyclic bases

    Directory of Open Access Journals (Sweden)

    G. H. PHILIP

    2010-01-01

    Full Text Available Mixed ligand complexes of nickel(II with 2,4-dihydroxyaceto-phenone oxime (DAPO and 2,4-dihydroxybenzophenone oxime (DBPO as primary ligands, and pyridine (Py and imidazole (Im as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II complexes.

  12. A dual-emissive ionic liquid based on an anionic platinum(II) complex

    OpenAIRE

    Ogawa, Tomohiro; Yoshida, Masaki; Ohara, Hiroki; Kobayashia, Atsushi; Kato, Masako

    2015-01-01

    An ionic liquid fabricated froman anionic cyclometalated platinum(II) complex and an imidazolium cation exhibits dual emission from the monomeric and aggregated forms of the platinum complex anions, leading to temperature-dependent color changes of luminescence.

  13. A dual-emissive ionic liquid based on an anionic platinum(ii) complex.

    Science.gov (United States)

    Ogawa, Tomohiro; Yoshida, Masaki; Ohara, Hiroki; Kobayashi, Atsushi; Kato, Masako

    2015-09-07

    An ionic liquid fabricated from an anionic cyclometalated platinum(ii) complex and an imidazolium cation exhibits dual emission from the monomeric and aggregated forms of the platinum complex anions, leading to temperature-dependent color changes of luminescence.

  14. Synthesis, characterization, fluorescence and biological studies of Mn(II, Fe(III and Zn(II complexes of Schiff bases derived from Isatin and 3-substituted-4-amino-5-mercapto-1,2,4-triazoles

    Directory of Open Access Journals (Sweden)

    Sangamesh A. Patil

    2014-12-01

    Full Text Available A series of Mn(II, Fe(III and Zn(II complexes have been synthesized with Schiff bases derived from isatin and 3-substituted-4-amino-5-mercapto-1,2,4-triazole. The elemental, spectroscopic (Infrared, nuclear magnetic resonance, ultraviolet-visible, fast atom bombardment-mass, fluorescence and electrochemistry and magnetic studies suggested that the metal complexes possess octahedral geometry. The Schiff bases and their metal complexes exhibit fluorescent properties. The antimicrobial studies of Schiff bases and their metal complexes against various bacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis and fungal (Aspergillus niger, and Penicillium chrysogenum species by the minimum inhibitory concentration method revealed that the metal complexes possess more healing antibacterial activities than the Schiff bases. DNA cleavage property of Mn(II, Fe(III and Zn(II complexes revealed the important role of metal ion in the biological system.

  15. Extraction of copper(II) ions from aqueous solutions with a methimazole-based ionic liquid.

    Science.gov (United States)

    Reyna-González, Juan M; Torriero, Angel A J; Siriwardana, Amal I; Burgar, Iko M; Bond, Alan M

    2010-09-15

    The recently synthesized ionic liquid (IL) 2-butylthiolonium bis(trifluoromethanesulfonyl)amide, [mimSBu][NTf(2)], has been used for the extraction of copper(II) from aqueous solution. The pH of the aqueous phase decreases upon addition of [mimSBu](+), which is attributed to partial release of the hydrogen attached to the N(3) nitrogen atom of the imidazolium ring. The presence of sparingly soluble water in [mimSBu][NTf(2)] also is required in solvent extraction studies to promote the incorporation of Cu(II) into the [mimSBu][NTf(2)] ionic liquid phase. The labile copper(II) system formed by interacting with both the water and the IL cation component has been characterized by cyclic voltammetry as well as UV-vis, Raman, and (1)H, (13)C, and (15)N NMR spectroscopies. The extraction process does not require the addition of a complexing agent or pH control of the aqueous phase. [mimSBu][NTf(2)] can be recovered from the labile copper-water-IL interacting system by washing with a strong acid. High selectivity of copper(II) extraction is achieved relative to that of other divalent cobalt(II), iron(II), and nickel(II) transition-metal cations. The course of microextraction of Cu(2+) from aqueous media into the [mimSBu][NTf(2)] IL phase was monitored in situ by cyclic voltammetry using a well-defined process in which specific interaction with copper is believed to switch from the ionic liquid cation component, [mimSBu], to the [NTf(2)] anion during the course of electrochemical reduction from Cu(II) to Cu(I). The microextraction-voltammetry technique provides a fast and convenient method to determine whether an IL is able to extract electroactive metal ions from an aqueous solution.

  16. PERCEPT-II: smartphone based indoor navigation system for the blind.

    Science.gov (United States)

    Ganz, Aura; Schafer, James M; Tao, Yang; Wilson, Carole; Robertson, Meg

    2014-01-01

    In this paper we introduce PERCEPT-II, a low cost and user friendly indoor navigation system for blind and visually impaired users. Using an Android Smartphone that runs PERCEPT-II application with accessibility features, the blind user obtains navigation instructions to the chosen destination when touching specific landmarks tagged with Near Field Communication tags. The system was deployed and tested in a large building at the University of Massachusetts at Amherst.

  17. Recent Advances in Platinum (IV) Complex-Based Delivery Systems to Improve Platinum (II) Anticancer Therapy.

    Science.gov (United States)

    Han, Xiaopeng; Sun, Jin; Wang, Yongjun; He, Zhonggui

    2015-11-01

    Cisplatin and its platinum (Pt) (II) derivatives play a key role in the fight against various human cancers such as testicular, ovarian, head and neck, lung tumors. However, their application in clinic is limited due to dose- dependent toxicities and acquired drug resistances, which have prompted extensive research effort toward the development of more effective Pt (II) delivery strategies. The synthesis of Pt (IV) complex is one such an area of intense research fields, which involves their in vivo conversion into active Pt (II) molecules under the reducing intracellular environment, and has demonstrated encouraging preclinical and clinical outcomes. Compared with Pt (II) complexes, Pt (IV) complexes not only exhibit an increased stability and reduced side effects, but also facilitate the intravenous-to-oral switch in cancer chemotherapy. The overview briefly analyzes statuses of Pt (II) complex that are in clinical use, and then focuses on the development of Pt (IV) complexes. Finally, recent advances in Pt (IV) complexes in combination with nanocarriers are highlighted, addressing the shortcomings of Pt (IV) complexes, such as their instability in blood and irreversibly binding to plasma proteins and nonspecific distribution, and taking advantage of passive and active targeting effect to improve Pt (II) anticancer therapy. © 2015 Wiley Periodicals, Inc.

  18. Femtomolar Zn(II) affinity in a peptide-based ligand designed to model thiolate-rich metalloprotein active sites.

    Science.gov (United States)

    Petros, Amy K; Reddi, Amit R; Kennedy, Michelle L; Hyslop, Alison G; Gibney, Brian R

    2006-12-11

    Metal-ligand interactions are critical components of metalloprotein assembly, folding, stability, electrochemistry, and catalytic function. Research over the past 3 decades on the interaction of metals with peptide and protein ligands has progressed from the characterization of amino acid-metal and polypeptide-metal complexes to the design of folded protein scaffolds containing multiple metal cofactors. De novo metalloprotein design has emerged as a valuable tool both for the modular synthesis of these complex metalloproteins and for revealing the fundamental tenets of metalloprotein structure-function relationships. Our research has focused on using the coordination chemistry of de novo designed metalloproteins to probe the interactions of metal cofactors with protein ligands relevant to biological phenomena. Herein, we present a detailed thermodynamic analysis of Fe(II), Co(II), Zn(II), and[4Fe-4S]2(+/+) binding to IGA, a 16 amino acid peptide ligand containing four cysteine residues, H2N-KLCEGG-CIGCGAC-GGW-CONH2. These studies were conducted to delineate the inherent metal-ion preferences of this unfolded tetrathiolate peptide ligand as well as to evaluate the role of the solution pH on metal-peptide complex speciation. The [4Fe-4S]2(+/+)-IGA complex is both an excellent peptide-based synthetic analogue for natural ferredoxins and is flexible enough to accommodate mononuclear metal-ion binding. Incorporation of a single ferrous ion provides the FeII-IGA complex, a spectroscopic model of a reduced rubredoxin active site that possesses limited stability in aqueous buffers. As expected based on the Irving-Williams series and hard-soft acid-base theory, the Co(II) and Zn(II) complexes of IGA are significantly more stable than the Fe(II) complex. Direct proton competition experiments, coupled with determinations of the conditional dissociation constants over a range of pH values, fully define the thermodynamic stabilities and speciation of each MII-IGA complex. The

  19. Rational design of two bpy-bridged 3D and 2D Co(II) open frameworks with similar amino-acid-based Schiff bases.

    Science.gov (United States)

    Li, Zong-Ze; Du, Lin; Zhou, Jie; Zhu, Ming-Rong; Qian, Fen-Hua; Liu, Jing; Chen, Peng; Zhao, Qi-Hua

    2012-12-21

    Two novel bpy-bridged Co(II) Schiff base complexes have been synthesized by the hydro(solvo)thermal reactions of corresponding amino-acid-based Schiff bases, bpy and Co(NO(3))(2)·6H(2)O. The following formulae identify the two complexes: {[Co(napala)(bpy)(0.5)]·H(2)O}(n) (1) and [Co(napgly)(bpy)(0.5)](n) (2) [H(2)napala = N-(2-hydroxy-1-naphthylmethylidene)-D/L-alanine, H(2)napgly = N-(2-hydroxy-1-naphthylmethylidene)-glycine and bpy = 4,4'-bipyridine]. These two compounds have been characterized using single-crystal X-ray diffraction, infrared, powder X-ray diffraction, thermogravimetric analysis, optical spectra analysis, and magnetic measurement. Complex 1 features an unprecedented threefold interpenetrated diamond network based on the fan-shaped Co(II)(4)(μ(2)-napala)(4) molecular square node and bpy linker, which represents the first example of 3D framework among the amino-acid-based Schiff base complexes with salicylaldehyde or its derivatives. In 2, adjacent Co(II) ions are bridged by μ(2)-napgly(2-) to form left- and right-handed [Co(II)(μ(2)-napgly)](n) helical chains. These two types of helical chains are sustained alternately by a symmetrical bpy co-ligand into a 2D grid-based layer. The solid-state fluorescence of complexes 1 and 2 are quenched almost completely compared with free mixed-ligands at room temperature. Moreover, magnetic studies show the dominant antiferromagnetic coupling between the Co(II) centers mediated by the syn-anti-COO(-)-bridges in both complexes.

  20. Monoenergetic positron beam at the reactor based positron source at FRM-II

    Science.gov (United States)

    Hugenschmidt, C.; Kögel, G.; Repper, R.; Schreckenbach, K.; Sperr, P.; Straßer, B.; Triftshäuser, W.

    2002-05-01

    The principle of the in-pile positron source at the Munich research reactor FRM-II is based on absorption of high energy prompt γ-rays from thermal neutron capture in 113Cd. For this purpose, a cadmium cap is placed inside the tip of the inclined beam tube SR-11 in the moderator tank of the reactor, where an undisturbed thermal neutron flux up to 2×10 14n cm-2 s-1 is expected. Inside the cadmium cap a structure of platinum foils is placed for converting high energy γ-radiation into positron-electron pairs. Due to the negative positron work function, moderation in annealed platinum leads to emission of monoenergetic positrons. Therefore, platinum will also be used as moderator, since its moderation property seems to yield long-term stability under reactor conditions and it is much easier to handle than tungsten. Model calculations were performed with SIMION-7.0w to optimise geometry and potential of Pt-foils and electrical lenses. It could be shown that the potentials between the Pt-foils must be chosen in the range of 1-10 V to extract moderated positrons. After successive acceleration to 5 keV by four electrical lenses the beam is magnetically guided in a solenoid field of 7.5 mT resulting in a beam diameter of about 25 mm. An intensity of about 10 10 slow positrons per second is expected in the primary positron beam. Outside of the reactor shield a W(1 0 0) single crystal remoderation stage will lead to an improvement of the positron beam brilliance before the positrons are guided to the experimental facilities.

  1. Model based design and analysis of phase II HIV-1 trials.

    Science.gov (United States)

    Rekić, Dinko; Röshammar, Daniel; Simonsson, Ulrika S H

    2013-08-01

    This work explores the advantages of a model based drug development (MBDD) approach for the design and analysis of antiretroviral phase II trials. Two different study settings were investigated: (1) a 5-arm placebo-controlled parallel group dose-finding/proof of concept (POC) study and (2) a comparison of investigational drug and competitor. Studies were simulated using a HIV-1 dynamics model in NONMEM. The Monte-Carlo Mapped Power method determined the sample size required for detecting a dose-response relationship and a significant difference in effect compared to the competitor using a MBDD approach. Stochastic simulation and re-estimation were used for evaluation of model parameter precision and bias given different sample sizes. Results were compared to those from an unpaired, two-sided t test and ANOVA (p ≤ 0.05). In all scenarios, the MBDD approach resulted in smaller study sizes and more precisely estimated treatment effect than conventional statistical analysis. Using a MBDD approach, a sample size of 15 patients could be used to show POC and estimate ED50 with a good precision (relative standard error, 25.7 %). A sample size of 10 patients per arm was needed using the MBDD approach for detecting a difference in treatment effect of ≥20 % at 80 % power, a 3.4-fold reduction in sample size compared to a t test. The MBDD approach can be used to achieve more precise dose-response characterization facilitating decision making and dose selection. If necessitated, the sample size needed to reach a desired power can potentially be reduced compared to traditional statistical analyses. This may allow for comparison against competitors already in early clinical studies.

  2. Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies.

    Science.gov (United States)

    Paixão, Drielly A; Marzano, Ivana M; Jaimes, Edgar H L; Pivatto, Marcos; Campos, Débora L; Pavan, Fernando R; Deflon, Victor M; Maia, Pedro Ivo da S; Da Costa Ferreira, Ana M; Uehara, Isadora A; Silva, Marcelo J B; Botelho, Françoise V; Pereira-Maia, Elene C; Guilardi, Silvana; Guerra, Wendell

    2017-07-01

    Five new copper(II) complexes of the type [Cu(NO)(NN)(ClO4)2], in which NO=4-fluorophenoxyacetic acid hydrazide (4-FH) or 4-nitrobenzoic hydrazide (4-NH) and NN=1,10-phenanthroline (phen), 4-4'-dimethoxy-2-2'-bipyridine (dmb) or 2,2-bipyridine (bipy) were synthesized and characterized using various spectroscopic methods. The X-ray structural analysis of one representative compound indicates that the geometry around the copper ion is distorted octahedron, in which the ion is coordinated to hydrazide via the terminal nitrogen and the carbonyl oxygen, and to heterocyclic bases via their two nitrogen atoms. Two perchlorate anions occupy the apical positions, completing the coordination sphere. The cytotoxic activity of compounds was investigated in three tumor cell lines (K562, MDA-MB-231 and MCF-7). Concerning K562 cell line, the complexes with 1,10-phenanthroline exhibit high cytotoxic activity and are more active than carboplatin, free ligands and [Cu(phen)2](2+). Considering the cytotoxicity results, further investigations for the compounds [Cu(4-FH)(phen)(ClO4)2] I and [Cu(4-NH)(phen)(ClO4)2]∙H2O III were performed. Flow cytometric analysis revealed that these complexes induce apoptotic cell death in MDA-MB-231 cell line and bind to DNA with K values of 4.38×10(4) and 2.62×10(4), respectively. These compounds were also evaluated against wild type Mycobacterium tuberculosis (ATCC 27294) and exhibited antimycobacterial activity, displayed MIC values lower than those of the corresponding free ligands. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. EPR interpretation, magnetism and biological study of a Cu(II) dinuclear complex assisted by a schiff base precursor.

    Science.gov (United States)

    Das, Kuheli; Patra, Chiranjit; Sen, Chandana; Datta, Amitabha; Massera, Chiara; Garribba, Eugenio; El Fallah, Mohamed Salah; Beyene, Belete B; Hung, Chen-Hsiung; Sinha, Chittaranjan; Askun, Tulin; Celikboyun, Pinar; Escudero, Daniel; Frontera, Antonio

    2016-12-30

    A new Cu(II) dinuclear complex, Cu2L2 (1) was afforded employing the potentially pentatentate Schiff base precursor H2L, a refluxed product of o-vanillin and diethylenetriamine in methanol. Complex 1 was systematically characterized by FTIR, UV-Vis, emission and EPR spectrometry. The single crystal X-ray diffraction analysis of 1 reveals that the copper atom exhibits a distorted square planar geometry, comprising two pairs of phenolato-O and imine-N donors from two different H2L ligands. The temperature dependent magnetic interpretation agrees with the existence of weak antiferromagnetic interactions between the bridging dinuclear Cu(II) ions. A considerable body of experimental evidence has been accumulated to elucidate the magneto-structural relationship in this dinuclear Cu(II) complex by DFT computation. Both the ligand and complex 1 exhibit anti-mycobacterial activity and considerable efficacy on M. tuberculosis H37Ra (ATCC 25177) and M. tuberculosis H37Rv (ATCC 25618) strains. The practical applicability of the ligand and complex 1 has been examined in living cells (African Monkey Vero Cells). The MTT assay proves the non-toxicity of the probe up to 100 mg mL(-1). A new homometallic dinuclear Cu(II) complex is afforded with a tetradentate Schiff base precursor. EPR interpretation and temperature dependent magnetic studies show that complex 1 has weak antiferromagnetic coupling and DFT computation is governed to explain the magneto-structural correlation.

  4. Spectral characterization, electrochemical and anticancer studies on some metal(II) complexes containing tridentate quinoxaline Schiff base

    Science.gov (United States)

    Chellaian, Justin Dhanaraj; Johnson, Jijo

    2014-06-01

    Co(II), Ni(II), Cu(II) and Zn(II) complexes of a tridentate ONO donor Schiff base ligand derived from 3-(2-aminoethylamino)quinoxalin-2(1H)-one were synthesized. The ligand and its metal complexes were characterized using elemental analysis, molar conductance, IR, 1H NMR, mass, magnetic susceptibility, electronic spectra and ESR spectral studies. Electrochemical behavior of the synthesized compounds was studied using cyclic voltammetry. The grain size of the synthesized compounds was determined by powder XRD. The Schiff base and its complexes have been screened for their antimicrobial activities against the bacterial species E. coli, K. pneumoniae, P. aeruginosa and S. aureus; fungal species include, A. niger, and C. albicans by disc diffusion method. The results show that the complexes have higher activity than the free ligand. The interaction of the complexes with calf thymus DNA (CT DNA) has been investigated by electronic absorption method. Furthermore, the DNA cleavage activity of the complexes was studied using agarose gel electrophoresis. In vitro anticancer studies of the ligand and its complexes using MTT assay was also done.

  5. A comparative evaluation of microleakage of restorations using silorane-based dental composite and methacrylate-based dental composites in Class II cavities: An in vitro study

    Directory of Open Access Journals (Sweden)

    Jambai Sampath Kumar Sivakumar

    2016-01-01

    Full Text Available Aim: The aim of this in vitro study was to evaluate and compare the microleakage of restorations using low shrinkage silorane-based dental composite and methacrylate-based dental composites in Class II cavity at the occlusal and gingival margins. Materials and Methods: Sixty mandibular molars were collected and divided into three experimental groups and one negative control group. Class II slot cavity was prepared on the mesial surface. Experimental groups were restored with Group I: silorane-based microhybrid composite, Group II: methacrylate-based nanohybrid composite, and Group III: Methacrylate-based microhybrid composite, respectively. Group IV: negative control. The samples were thermocycled, root apices were sealed with sticky wax and coated with nail varnish except 1 mm around the restoration. This was followed by immersion in 2% Rhodamine-B dye solution under vacuum at room temperature for 24 h. Then, the samples were sectioned longitudinally in the mesiodistal direction and evaluated under stereomicroscope ×40 magnification. Scoring was done according to the depth of dye penetration in to the cavity. Statistical analysis of the data was done. Results: The results were that no statistically significant difference in the microleakage at the occlusal margin for all the restorative materials, whereas at the gingival margin, silorane-based microhybrid composite showed less microleakage than the methacrylate-based nano- and micro-hybrid composites. Conclusion: In general, silorane-based microhybrid composite had less microleakage among the other materials used in this in vitro study.

  6. PVC Based Membrane of Ti(IV Iodovanadate for Pb(II Determination

    Directory of Open Access Journals (Sweden)

    Mu. Naushad

    2008-08-01

    Full Text Available Ti(IV iodovanadate has been synthesized by mixing a mixture of aqueous solutions of 0.1 M sodium vanadate and 0.1 M potassium iodate with 0.1 M solution of Ti(IV chloride at pH 1.0. Distribution coefficients (Kd of various metal ions were determined on the column of Ti(IV iodovanadate which showed the selectivity of Pb(II ions by this cation exchange material. So Ti(IV iodovanadate has been used as an electoactive material for the construction of Pb(II selective electrode. The main purpose of this study is to develop an inexpensive, simple and reliable ion-selective electrode for Pb(II determination. The sensor exhibit Nernstian response for Pb(II ions over a wide concentration range of 1 x 10-7 M to 1 x 10-1 M with a slope of 30±0.4 mV per decade of activity. The electrode is suitable for use in aqueous solution in a pH range of 2-7.2 with a response time of 10 second. The membrane electrode can be used at least for 4 months without any divergence in potential. The selectivity coefficients were determined by the mixed solution method and revealed that the electrode was selective for Pb(II ions in the presence of interfering cations. The sensor could be used as an indicator electrode in the potentiometric titration of Pb(II ions with EDTA. The practical applicability of the proposed sensor has been reported for Pb(II determination in a standard rock sample and water sample. The results are found to be in good agreement with those obtained by using conventional methods.

  7. Cause-specific effects of radiotherapy and lymphadenectomy in stage I-II endometrial cancer: a population-based study.

    Science.gov (United States)

    Mell, Loren K; Carmona, Ruben; Gulaya, Sachin; Lu, Tina; Wu, John; Saenz, Cheryl C; Vaida, Florin

    2013-11-06

    Radiotherapy and lymphadenectomy have been associated with improved survival in population-based studies of endometrial cancer, which is in contrast with findings from randomized trials and meta-analyses. The primary study aim was to estimate the cause-specific effects of adjuvant radiotherapy and lymphadenectomy on competing causes of mortality. We analyzed Surveillance, Epidemiology, and End Results (SEER) data from 1988 to 2006. The sample comprised 58172 patients with stage I and II endometrial adenocarcinoma. Patients were risk stratified by stage, grade, and age. Cumulative incidences and cause-specific hazards of competing causes of mortality were estimated according to treatment. All statistical tests were two-sided. Pelvic radiotherapy was associated with statistically significantly increased endometrial cancer mortality (hazard ratio [HR] = 1.66; 95% confidence interval [CI] = 1.52 to 1.82) in all stage I and II patients and decreased noncancer mortality in intermediate and high-risk stage I and II patients (HR = 0.82; 95% CI = 0.77 to 0.89). Lymphadenectomy was associated with increased endometrial cancer mortality in stage I patients (HR = 1.27; 95% CI = 1.16 to 1.39), decreased endometrial cancer mortality in stage II patients (HR = 0.61; 95% CI = 0.52 to 0.72), and decreased noncancer mortality in both stage I and II patients (HR = 0.84; 95% CI = 0.80 to 0.88). Effects of radiotherapy and lymphadenectomy on second cancer mortality varied according to risk strata. Radiotherapy and lymphadenectomy are associated with statistically significantly reduced noncancer mortality in stage I and II endometrial cancer. The improved overall survival associated with these treatments reported from SEER studies is largely attributable to their selective application in healthier patients rather than their effects on endometrial cancer.

  8. Cd(II) complexes with different nuclearity and dimensionality based on 3-hydrazino-4-amino-1,2,4-triazole

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Cai-Xia; Zhang, Jian-Guo, E-mail: zjgbit@bit.edu.cn; Yin, Xin; Jin, Xin; Li, Tong; Zhang, Tong-Lai; Zhou, Zun-Ning

    2015-03-15

    A series of zero- to two-dimensional Cd(II) coordination compounds have been synthesized by the reaction of Cd(II) salts and 3-hydrazino-4-amino-1,2,4-triazole di-hydrochloride (HATr·2HCl). [CdCl{sub 2}(HATr){sub 2}] (1) and [Cd{sub 2}Cl{sub 4}(HATr){sub 2}(H{sub 2}O){sub 2}] (2) have discrete mononuclear and binuclear structures, respectively. [Cd(HATr){sub 2}(ClO{sub 4}){sub 2}]{sub n} (3) presents polymeric 1-D chain and [Cd{sub 2}(NO{sub 3}){sub 2}Cl{sub 2}(HATr){sub 2}]{sub n} (4) shows 2-D frameworks. All Cd(II) ions exhibit distorted octahedral configurations in 1–3, whilst both hexa and heptacoordinated Cd(II) are formed in 4. The HATr ligands adopt chelating coordinated mode in 1, while tri-dentate bridging–chelating mode in 2–4. The chloride ion is a mono-coordinated ligand in 1 and 2, but it bridges two adjacent metal ions in 4. Furthermore, thermal behaviors have been investigated and the results reveal that all complexes have good thermal stability. The impact sensitivity test indicates that complex 3 is sensitive to impact stimuli. - Graphical abstract: Four Cd(II) complexes based on 3-hydrazino-4-amino-1,2,4-triazole ligands exhibit diverse structures from mononuclear to 2D networks. - Highlights: • Cd(II) complexes containing 3-hydrazino-4-amino-1,2,4-triazole ligands. • Mononuclear, binuclear, 1-D and 2-D structures. • Good thermal stability. • Thermal decomposition kinetics.

  9. Synthesis, spectroscopic, fluorescence properties and biological evaluation of novel Pd(II) and Cd(II) complexes of NOON tetradentate Schiff bases.

    Science.gov (United States)

    Ali, Omyma A M

    2014-01-01

    The solid complexes of Pd(II) and Cd(II) with N,N/bis(salicylaldehyde)4,5-dimethyl-1,2-phenylenediamine (H2L(1)), and N,N/bis(salicylaldehyde)4,5-dichloro-1,2-phenylenediamine (H2L(2)) have been synthesized and characterized by several techniques using elemental analysis (CHN), FT-IR, (1)H NMR, UV-Vis spectra and thermal analysis. Elemental analysis data proved 1:1 stoichiometry for the reported complexes while spectroscopic data indicated square planar and octahedral geometries for Pd(II) and Cd(II) complexes, respectively. The prepared ligands, Pd(II) and Cd(II) complexes exhibited intraligand (π-π(∗)) fluorescence and can potentially serve as photoactive materials. Thermal behavior of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. Both the ligands and their complexes have been screened for antimicrobial activities.

  10. TARGET ANALYSIS OF SUZHOU CREEK REHABILITATION PROJECT STAGE II:BASED ON WATER QUALITY MODEL

    Institute of Scientific and Technical Information of China (English)

    LIAO Zhen-liang; XU Zu-xin

    2004-01-01

    The Suzhou Creek is a seriously polluted tidal river in Shanghai. The Suzhou Creek Rehabilitation Project was launched in 1998, and the total investment will surpass 10 billion yuan RMB. It is important to assess the effectiveness of the project and ascertain its targets. In this study, by analyzing the achievements of Suzhou Creek Rehabilitation Project (Stage I) and its remaining problems, the main tasks of the Project Stage II are proposed. These works are wastewater interception, sediment dredging, bidirectional water diversion, and reconstruction of municipal pump stations. The water quality model established with USEPA's WASP is employed to analyze the quantitative targets of the Project Stage II. In the Project Stage II, the water quality of mainstream and tributaries will be improved continuously, the valus of CODCr, BOD5, DO in the mainstream will steadily attain Class IV according to the National Surface Water Quality Standard, and the ecological environment of Suzhou Creek with continuously recover.

  11. Selection of Chelated Fe (III)/Fe (II) Catalytic Oxidation Agents for Desulfurization Based on Iron Complexation Method

    Institute of Scientific and Technical Information of China (English)

    Luo Ying; Liu Youzhi; Qi Guisheng; Guo Huidong; Zhu Zhengfeng

    2014-01-01

    Optimization of factors inlfuencing the experiments on reactions involving 8 different chelating agents and sol-uble Fe (III)/Fe (II) salts was carried out to yield chelated iron complexes. A combination of optimized inlfuencing factors has resulted in a Fe chelating capacity of the iron-based desulfurization solution to be equal to 6.83-13.56 g/L at a redox potential of 0.185-0.3. The desulfurization performance of Fe (III)/Fe (II) chelating agents was investigated on a simulated sulfur-containing industrial gas composed of H2S and N2 in a cross-lfow rotating packed bed. Test results have revealed that the proposed iron-based desulfurization solution showed a sulfur removal efifciency of over 99%along with a Fe chelating capacity exceeding 1.35 g/L. This desulfurization technology which has practical application prospect is currently in the phase of commercial scale-up study.

  12. Detailed study of the column-based priority logic readout of Topmetal-II- CMOS pixel direct charge sensor

    CERN Document Server

    An, Mangmang; Gao, Chaosong; Han, Mikyung; Huang, Guangming; Ji, Rong; Li, Xiaoting; Mei, Yuan; Pei, Hua; Sun, Quan; Sun, Xiangming; Wang, Kai; Xiao, Le; Yang, Ping; Zhang, Wei; Zhou, Wei

    2016-01-01

    We present the detailed study of the digital readout of Topmetal-II- CMOS pixel direct charge sensor. Topmetal-II- is an integrated sensor with an array of 72X72 pixels each capable of directly collecting external charge through exposed metal electrodes in the topmost metal layer. In addition to the time-shared multiplexing readout of the analog output from Charge Sensitive Amplifiers in each pixel, hits are also generated through comparators with individually DAC settable thresholds in each pixel. The hits are read out via a column-based priority logic structure, retaining both hit location and time information. The in-array column-based priority logic is fully combinational hence there is no clock distributed in the pixel array. Sequential logic and clock are placed on the peripheral of the array. We studied the detailed working behavior and performance of this readout, and demonstrated its potential in imaging applications.

  13. All-optical switching and limiting properties of a Ru (II) Schiff-base complex for nonlinear optical applications

    Science.gov (United States)

    Manjunatha, K. B.; Rajarao, Ravindra; Umesh, G.; Ramachandra Bhat, B.; Poornesh, P.

    2017-08-01

    A salen-based ruthenium (Ru) (II) complex was synthesized for possible use in nonlinear optical device applications. The Ru complex was doped in a polymer matrix to fabricate films using a low-cost spin-coating technique. The third-order nonlinear optical parameters of the complex were investigated by Z-scan and degenerate four-wave mixing techniques. The study reveals two-order enhancement of third-order optical susceptibility χ (3) and exhibits superior limiting capability due to a reverse saturable absorption process. All-optical switching action for the films indicates that the sample can function as an optical inverter or a NOT gate. Hence, the Ru (II) Schiff-base complex materializes as a possible candidate for use in nonlinear optical devices.

  14. Synthesis and characterization of a ruthenium(II)-based redox conjugate for reagentless biosensing.

    Science.gov (United States)

    Trammell, S A; Goldston, H M; Tran, P T; Tender, L M; Conrad, D W; Benson, D E; Hellinga, H W

    2001-01-01

    Synthesis of a novel sulfhydryl-specific, tetraammine Ru(II)polypyridyl complex, [Ru(II)(NH(3))(4)(1,10-phenanthroline-5-maleimide)](PF(6))(2), which exhibits environment-sensitive electrochemical properties is described. When conjugated to an allosteric site in a genetically engineered mutant of maltose binding protein, the formal potential of the conjugated redox probe is shifted to higher potential upon maltose binding. The magnitude of this potential shift was used to measure maltose affinity of the protein-redox conjugate complex and to monitor maltose concentration in solution. These results are presented in context of reagentless biosensing.

  15. The mechanism for degrading Orange II based on adsorption and reduction by ion-based nanoparticles synthesized by grape leaf extract

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Fang; Yang, Die [Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095 (Australia); Cooperative Research Centre for Contamination Assessment and Remediation of Environments, University of South Australia, Mawson Lakes, SA 5095 (Australia); Chen, Zuliang, E-mail: zuliang.chen@unisa.edu.au [Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095 (Australia); Cooperative Research Centre for Contamination Assessment and Remediation of Environments, University of South Australia, Mawson Lakes, SA 5095 (Australia); Megharaj, Mallavarapu; Naidu, Ravendra [Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095 (Australia); Cooperative Research Centre for Contamination Assessment and Remediation of Environments, University of South Australia, Mawson Lakes, SA 5095 (Australia)

    2015-10-15

    Biomolecules taken from plant extracts have often been used in the single-step synthesis of iron-based nanoparticles (Fe NPs) due to their low cost, environmental safety and sustainable properties. However, the composition of Fe NPs and the degradation mechanism of organic contaminants by them are limited because these are linked to the reactivity of Fe NPs. In this study, Fe NPs synthesized by grape leaf extract served to remove Orange II. Batch experiments showed that more than 92% of Orange II was removed by Fe NPs at high temperature based on adsorption and reduction and confirmed by kinetic studies. To understand the role of Fe NPs in the removal process of azo dye, surface analysis via X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM) were employed, showing that the Fe NPs were composed of biomolecules, hydrous iron oxides and Fe{sup 0}, thus providing evidence for the adsorption of Orange II onto hydrous iron oxides and its reduction by Fe{sup 0}. Degraded products such as 2-naphthol were identified using LC–MS analysis. A degradation mechanism based on asymmetrical azo bond cleavage for the removal of Orange II was proposed.

  16. Copper (II) and zinc (ii) metal-based salicyl-, furanyl-, thienyl- and pyrrolyl-derived ONNO, NNNO, ONNS & NNNS donor asymmetrically mixed schiff-bases with antibacterial and antifungal potentials.

    Science.gov (United States)

    Chohan, Zahid H; Arif, M; Rashid, A

    2008-12-01

    A new series of asymmetric salicyl-, furanyl-, thienyl- and pyrrolyl-derived ONNO, NNNO, ONNS & NNNS donor antibacterial and antifungal Schiff-bases and their copper(II) and zinc(II) metal complexes have been synthesized and characterized. IR spectra indicated the ligands to act as quartdentate towards divalent metal ions via two azomethine-N, deprotonated-O of salicyl, furanyl-O, thienyl-S and/or pyrrolyl-N. The magnetic moments and electronic spectral data suggest octahedral geometry for Cu(II) and Zn(II) complexes. NMR spectral data of the ligands and their diamagnetic zinc(II) complexes well-define their proposed structures/geometries. Elemental analyses data of the ligands and metal complexes agree with their proposed structures/geometries. The synthesized ligands, along with their metal complexes were screened for their antibacterial activity against B. cereus, C. diphtheriae, E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa, S. typhi, S. dysenteriae and S. aureus strains and for in-vitro antifungal activity against T. schoenleinii, C. glabrata, P. boydii, C. albicans, A. niger, M. canis and T. mentagrophytes. The results of these studies show the metal complexes to be more antibacterial/antifungal against one or more species as compared to the uncomplexed ligands. The brine shrimp bioassay was also carried out to study their in-vitro cytotoxic properties. Eight compounds, L(4), (1), (7), (8), (11), (17), (19) and (23) displayed potent cytotoxic activity with LD(50) = 1.445 x 10(- 3), 1.021 x 10(- 3), 7.478 x 10(- 4), 8.566 x 10(- 4), 1.028 x 10(- 3), 9.943 x 10(- 4), 8.730 x 10(- 4) and 1.124 x 10(- 3) M respectively, against Artemia salina.

  17. Synthesis, structural characterization, fluorescence, antimicrobial, antioxidant and DNA cleavage studies of Cu(II) complexes of formyl chromone Schiff bases.

    Science.gov (United States)

    Kavitha, P; Saritha, M; Laxma Reddy, K

    2013-02-01

    Cu(II) complexes have been synthesized from different Schiff bases, such as 3-((2-hydroxy phenylimino)methyl)-4H-chromen-4-one (HL(1)), 2-((4-oxo-4H-chromen-3-yl)methylneamino) benzoicacid (HL(2)), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL(3)) and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL(4)). The complexes were characterized by analytical, molar conductance, IR, electronic, magnetic, ESR, thermal, powder XRD and SEM studies. The analytical data reveal that metal to ligand molar ratio is 1:2 in all the complexes. Molar conductivity data indicates that all the Cu(II) complexes are neutral. On the basis of magnetic and electronic spectral data, distorted octahedral geometry is proposed for all the Cu(II) complexes. Thermal behaviour of the synthesized complexes illustrates the presence of lattice water molecules in the complexes. X-ray diffraction studies reveal that all the ligands and their Cu(II) complexes have triclinic system with different unit cell parameters. Antimicrobial, antioxidant and DNA cleavage activities indicate that metal complexes exhibited greater activity as compared with ligands.

  18. Synthesis, structural characterization, fluorescence, antimicrobial, antioxidant and DNA cleavage studies of Cu(II) complexes of formyl chromone Schiff bases

    Science.gov (United States)

    Kavitha, P.; Saritha, M.; Laxma Reddy, K.

    2013-02-01

    Cu(II) complexes have been synthesized from different Schiff bases, such as 3-((2-hydroxy phenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino) benzoicacid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3) and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4). The complexes were characterized by analytical, molar conductance, IR, electronic, magnetic, ESR, thermal, powder XRD and SEM studies. The analytical data reveal that metal to ligand molar ratio is 1:2 in all the complexes. Molar conductivity data indicates that all the Cu(II) complexes are neutral. On the basis of magnetic and electronic spectral data, distorted octahedral geometry is proposed for all the Cu(II) complexes. Thermal behaviour of the synthesized complexes illustrates the presence of lattice water molecules in the complexes. X-ray diffraction studies reveal that all the ligands and their Cu(II) complexes have triclinic system with different unit cell parameters. Antimicrobial, antioxidant and DNA cleavage activities indicate that metal complexes exhibited greater activity as compared with ligands.

  19. A water-soluble and retrievable ruthenium-based probe for colorimetric recognition of Hg(II) and Cys

    Science.gov (United States)

    Cui, Yali; Hao, Yuanqiang; Zhang, Yintang; Liu, Baoxia; Zhu, Xu; Qu, Peng; Li, Deliang; Xu, Maotian

    2016-08-01

    A new ruthenium-based complex 1 [(bis(4,4‧-dimethylphosphonic-2,2‧-bipyridine) dithiocyanato ruthenium (II))] was developed as a colorimetric probe for the detection of Hg(II) and Cys (Cysteine). The obtained compound 1 can give interconversional color changes upon the alternating addition of Hg(II) and Cys in 100% aqueous solution. The specific coordination between NCS groups with Hg(II) can lead to the formation of 1-Hg2 + complex, which can induce a remarkable spectral changes of probe 1. Afterwards the formed 1-Hg2 + complex can act as effective colorimetric sensor for Cys. Owing to the stronger binding affinity of sulfhydryl group to Hg2 +, Cys can extract Hg2 + from 1-Hg2 + complex resulting in the release of 1 and the revival of absorption profile of the probe 1. By introducing the hydrophilic phosphonic acid groups, the proposed probe exhibited excellent water solubility. The limits of detection (LODs) of the assay for Hg2 + and Cys are calculated to be 15 nM and 200 nM, respectively.

  20. Complex of manganese (II) with curcumin: Spectroscopic characterization, DFT study, model-based analysis and antiradical activity

    Science.gov (United States)

    Gorgannezhad, Lena; Dehghan, Gholamreza; Ebrahimipour, S. Yousef; Naseri, Abdolhossein; Nazhad Dolatabadi, Jafar Ezzati

    2016-04-01

    The complex formation between curcumin (Cur) and Manganese (II) chloride tetrahydrate (MnCl2.4H2O) was studied by UV-Vis and IR spectroscopy. Spectroscopic data suggest that Cur can chelate Manganese cations. A simple multi-wavelength model-based method was used to define stability constant for complexation reaction regardless of the spectra overlapping of components. Also, pure spectra and concentration profiles of all components were extracted using this method. Density functional theory (DFT) was also used to view insight into complexation mechanism. Antioxidant activity of Cur and Cur-Mn(II) complex was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging method. Bond dissociation energy (BDE), the highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO) and Molecular electrostatic potential (MEP) of Cur and the complex also were calculated at PW91/TZ2P level of theory using ADF 2009.01 package. The experimental results show that Cur has a higher DPPH radical scavenging activity than Cur-Mn(II). This observation is theoretically justified by means of lower BDE and higher HOMO and LUMO energy values of Cur ligand as compared with those of Cur-Mn(II) complex.

  1. Trace analysis of cefotaxime at carbon paste electrode modified with novel Schiff base Zn(II) complex.

    Science.gov (United States)

    Nigam, Preeti; Mohan, Swati; Kundu, Subir; Prakash, Rajiv

    2009-02-15

    Cefotaxime a third generation cephalosporin drug estimation in nanomolar concentration range is demonstrated for the first time in aqueous and human blood samples using novel Schiff base octahedral Zn(II) complex. The cefotaxime electrochemistry is studied over graphite paste and Zn(II) complex modified graphite paste capillary electrodes in H(2)SO(4) (pH 2.3) using cyclic voltammetry and differential pulse voltammetry. Cefotaxime enrichment is observed over Zn(II) complex modified graphite paste electrode probably due to interaction of functional groups of cefotaxime with Zn(II) complex. Possible interactions between metal complex and cefotaxime drug is examined by UV-vis and electrochemical quartz crystal microbalance (EQCM) techniques and further supported by voltammetric analysis. Differential pulse voltammetry (DPV) with modified electrode is applied for the determination of cefotaxime in acidified aqueous and blood samples. Cefotaxime estimation is successfully demonstrated in the range of 1-500 nM for aqueous samples and 0.1-100 microM in human blood samples. Reproducibility, accuracy and repeatability of the method are checked by triplicate reading for large number of samples. The variation in the measurements is obtained less than 10% without any interference of electrolyte or blood constituents.

  2. A new chitosan Schiff base supported Pd(II) complex for microwave-assisted synthesis of biaryls compounds

    Science.gov (United States)

    Baran, Talat

    2017-08-01

    In this study, a new heterogeneous palladium (II) catalyst that contains O-carboxymethyl chitosan Schiff base has been designed for Suzuki coupling reactions. The chemical structures of the synthesized catalyst were characterized with the FTIR, TG/DTG, ICP-OES, SEM/EDAX, 1H NMR, 13C NMR, GC/MS, XRD, and magnetic moment techniques. The reusability and catalytic behavior of heterogeneous catalyst was tested towards Suzuki reactions. As a result of the tests, excellent selectivity was obtained, and by-products of homo coupling were not seen in the spectra. The biaryls products were identified on a GC/MS. In addition, it was determined in the reusability tests that the catalysts could be used several times (seven runs). More importantly, with very low catalyst loading (6 × 10-3 mol %) in very short reaction time (5 min), chitosan Schiff base supported Pd(II) complex gave high TON and TOF values. These findings showed that Schiff base supported Pd(II) catalyst is suitable for Suzuki cross coupling reactions.

  3. Mustard gas and American race-based human experimentation in World War II.

    Science.gov (United States)

    Smith, Susan L

    2008-01-01

    This essay examines the risks of racialized science as revealed in the American mustard gas experiments of World War II. In a climate of contested beliefs over the existence and meanings of racial differences, medical researchers examined the bodies of Japanese American, African American, and Puerto Rican soldiers for evidence of how they differed from whites.

  4. Preconcentration of Zn(II) in water samples using a new hybrid SBA-15-based material

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Quintanilla, Damian; Sanchez, Alfredo; Hierro, Isabel del; Fajardo, Mariano [Departamento de Quimica Inorganica y Analitica, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipan s/n, 28933 Mostoles, Madrid (Spain); Sierra, Isabel, E-mail: isabel.sierra@urjc.es [Departamento de Quimica Inorganica y Analitica, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipan s/n, 28933 Mostoles, Madrid (Spain)

    2009-07-30

    A SBA-15 mesoporous silica has been chemically modified with 5-mercapto-1-methyltetrazole. The newly synthesized material (MTTZ-SBA-15) has been characterized, by powder X-ray diffraction, N{sub 2} adsorption, FT-IR, {sup 13}C NMR spectroscopy and elemental analysis, and used to preconcentrate Zn(II) in water samples. The effect of some variables on the adsorption capacity has been studied using the column techniques. The adsorption capacity of the prepared material followed the order: Zn >> Cu > Cd >> Mn, and under optimized conditions the maximum adsorption value for Zn(II) was 0.96 {+-} 0.01 mmol/g with the adsorption efficiency of 0.76. In column experiments, adsorption was quantitative for 1000 mL of 7.65 x 10{sup -4} mM of Zn(II) solution and adsorbed ions were eluted out by 5 mL of 1 M HCl (preconcentration factor of 200). Spiked tap water and mineral water were used for the preconcentration and determination of Zn(II) by flame atomic absorption spectrometry (FAAS), and a 102 {+-} 2 and 98 {+-} 3% recoveries were obtained. The LOD and LOQ values of the proposed method were found to be 8.0 x 10{sup -6} and 1.23 x 10{sup -5} mM, respectively. The relative standard deviation for four preconcentration experiments was found to be {<=}4% in all cases.

  5. Novel Silica-Based Hybrid Adsorbents: Lead(II Adsorption Isotherms

    Directory of Open Access Journals (Sweden)

    Junsheng Liu

    2013-01-01

    Full Text Available Water pollution caused by the lead(II from the spent liquor has caught much attention. The research from the theoretical model to application fundaments is of vital importance. In this study, lead(II adsorption isotherms are investigated using a series of hybrid membranes containing mercapto groups (–SH groups as the hybrid adsorbents. To determine the best fitting equation, the experimental data were analyzed using six two-parameter isotherm equations (i.e., Langmuir, Freundlich, Dubinin-Radushkevich (D-R, Temkin, Harkins-Jura, and Halsey isotherm models. It was found that the lead(II adsorption on these samples followed the Freundlich, Dubinin-Radushkevich (D-R, and Halsey isotherm models. Moreover, the mean free energy of adsorption was calculated using Dubinin-Radushkevich (D-R isotherm model and it was confirmed that the adsorption process was physical in nature. These findings are very meaningful in the removal of lead(II ions from water using the hybrid membranes as adsorbents.

  6. Adsorption Batch Studies on the Removal of Pb(II Using Maize Tassel Based Activated Carbon

    Directory of Open Access Journals (Sweden)

    Mambo Moyo

    2013-01-01

    Full Text Available The demand for clean water is on the increase as rapid industrialization is still contributing to pollution. Nowadays, as water is the basic need for mankind, efforts have gathered momentum to decontaminate it in order to address the acute shortage of clean and pure water. Maize tassel was used as the precursor for making activated carbon for the adsorption of Pb(II ions. The product obtained was characterized and utilized for the removal of Pb(II from aqueous solutions over a wide range of initial metal ion concentration (10–50 mg/L, contact time (5–300 min, adsorbent dose (0.1–2.5 g, and pH (2–12. The optimum set of conditions for biosorption of Pb(II ion were found to be initial concentration 10 mg/L, dosage 1.2 g, and pH 5.4. The adsorption data conformed to both the Langmuir and the Freundlich isotherms but fitted best into the Langmuir model. The R2 for Langmuir equation was 0.9997 and that for Freundlich was 0.9515. The Langmuir monolayer adsorption capacity of the activated carbon was calculated to be 37.31 mg/g. The results indicate that activated carbon might be used to effectively adsorb Pb(II ions from wastewater treatment plants.

  7. Unique Ligand-Based Oxidative DNA Cleavage by Zinc(II) Complexes of Hpyramol and Hpyrimol

    NARCIS (Netherlands)

    Maheswari, P.U.; Barends, S.; Özalp-Yaman, S.; de Hoog, P.; Casellas, H.; Teat, S.J.; Massera, C.; Lutz, M.; Spek, A.L.; van Wezel, G.P.; Gamez, P.; Reedijk, J.

    2007-01-01

    The zinc(II) complexes reported here have been synthesised from the ligand 4-methyl-2-N-(2-pyridylmethyl)aminophenol (Hpyramol) with chloride or acetate counterions. All the five complexes have been structurally characterised, and the crystal structures reveal that the ligand Hpyramol gradually unde

  8. Selective NO trapping in the pores of chain-type complex assemblies based on electronically activated paddlewheel-type [Ru2(II,II)]/[Rh2(II,II)] dimers.

    Science.gov (United States)

    Kosaka, Wataru; Yamagishi, Kayo; Hori, Akihiro; Sato, Hiroshi; Matsuda, Ryotaro; Kitagawa, Susumu; Takata, Masaki; Miyasaka, Hitoshi

    2013-12-11

    The design of porous materials that undergo selective adsorption of a specific molecule is a critical issue in research on porous coordination polymers or metal-organic frameworks. For the purpose of the selective capture of molecules possessing an electron-acceptor character such as nitric oxide (NO), one-dimensional chain compounds possessing a high donor character have been synthesized using 4-chloroanisate-bridged paddlewheel-type dimetal(II, II) complexes with M = Ru and Rh and phenazine (phz) as the chain linker: [M2(4-Cl-2-OMePhCO2)4(phz)]·n(CH2Cl2) (M = Ru, 1; Rh, 2). These compounds are isostructural and are composed of chains with a [-{M2}-phz-] repeating unit and CH2Cl2 occupying the void space between the chains. Compounds 1 and 2 change to a new phase (1-dry and 2-dry) upon evacuating the crystallization solvent (CH2Cl2) and almost lose their pores in the drying process: no void space in 1-dry and 31.8 Å(3), corresponding to 2.9% of the cell volume, in 2-dry. Nevertheless, the compounds show a unique gas accommodation ability. Accompanied by a structural transformation (i.e., the first gate-opening) at low pressures of molecules per [M2] unit. In addition, the adsorption isotherm for NO (121 K) involves the first gate-opening followed by a second gate-opening anomaly at NO pressures of ≈52 kPa for 1-dry and ≈21 kPa for 2-dry. At the first gate-opening, the absorbed amount of NO is ca. 4 molecules per [M2] unit, and then it reaches 8.4 and 6.3 for 1-dry and 2-dry, respectively, at 95 kPa. Only the isotherm for NO exhibits hysteresis in the desorption process, and some of the NO molecules are trapped in pores even after evacuating at 121 K, although it recovers to the original dried sample on heating to room temperature. The adsorbed NO molecules accrue a significant electron donation from the host framework even in the [Rh2] derivative, indicating that such simple porous compounds with electron-donor characteristics are useful for the selective

  9. TBscore II

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Lemvik, Grethe; Abate, Ebba;

    2013-01-01

    Abstract Background: The TBscore, based on simple signs and symptoms, was introduced to predict unsuccessful outcome in tuberculosis patients on treatment. A recent inter-observer variation study showed profound variation in some variables. Further, some variables depend on a physician assessing...... them, making the score less applicable. The aim of the present study was to simplify the TBscore. Methods: Inter-observer variation assessment and exploratory factor analysis were combined to develop a simplified score, the TBscore II. To validate TBscore II we assessed the association between start...

  10. Octahedral Ni(II) complex with new NNO donor Schiff base ligand: Synthesis, structure and Hirshfeld surface

    Science.gov (United States)

    Jana, Kalyanmoy; Maity, Tithi; Chandra Debnath, Subhas; Samanta, Bidhan Chandra; Seth, Saikat Kumar

    2017-02-01

    A new mononuclear Schiff base octahedral Ni(II) complex of general formula [NiII(L)2] has been synthesized using a new NNO donor Schiff base ligand (HL = 2-[(piperidin-2-ylmethylimino)-methyl]-phenol). The title complex has been characterized by various physical measurements such as elemental analyses, FT-IR, 1H NMR and UV-Vis spectroscopic techniques. The molecular structure of the title complex was determined by single crystal X-ray diffraction technique. The title complex is a mononuclear bis-ligand complex showing distorted octahedral geometry around nickel (II). X-ray crystallography reveals that the complex exhibits extensive supramolecular interactions in the solid-state. Two types of non-covalent interactions namely, π-π and C-H···π interactions are found to govern final solid-state architecture in the complex. The contribution of each interaction to the formation of the self-assembly has been analyzed through Hirshfeld surface calculation which enables quantitative contributions to the crystal packing in a novel visual manner.

  11. Modeling Pb (II) adsorption from aqueous solution by ostrich bone ash using adaptive neural-based fuzzy inference system.

    Science.gov (United States)

    Amiri, Mohammad J; Abedi-Koupai, Jahangir; Eslamian, Sayed S; Mousavi, Sayed F; Hasheminejad, Hasti

    2013-01-01

    To evaluate the performance of Adaptive Neural-Based Fuzzy Inference System (ANFIS) model in estimating the efficiency of Pb (II) ions removal from aqueous solution by ostrich bone ash, a batch experiment was conducted. Five operational parameters including adsorbent dosage (C(s)), initial concentration of Pb (II) ions (C(o)), initial pH, temperature (T) and contact time (t) were taken as the input data and the adsorption efficiency (AE) of bone ash as the output. Based on the 31 different structures, 5 ANFIS models were tested against the measured adsorption efficiency to assess the accuracy of each model. The results showed that ANFIS5, which used all input parameters, was the most accurate (RMSE = 2.65 and R(2) = 0.95) and ANFIS1, which used only the contact time input, was the worst (RMSE = 14.56 and R(2) = 0.46). In ranking the models, ANFIS4, ANFIS3 and ANFIS2 ranked second, third and fourth, respectively. The sensitivity analysis revealed that the estimated AE is more sensitive to the contact time, followed by pH, initial concentration of Pb (II) ions, adsorbent dosage, and temperature. The results showed that all ANFIS models overestimated the AE. In general, this study confirmed the capabilities of ANFIS model as an effective tool for estimation of AE.

  12. Tris(2,2'-bipyridyl) ruthenium(II)-bisoprolol-based electrochemiluminescence coupled with capillary zone electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jingwu [Department of Chemistry, Nanchang University, Nanchang 330031 (China)], E-mail: wangjingwu@ncu.edu.cn; Zhang Xiaojun; Pi Fangfang [Department of Chemistry, Nanchang University, Nanchang 330031 (China); Wang Xiaoxia [Graduate School of Engineering, University of Fukui, Fukui 910-8507 (Japan); Yang Nianjun [Diamond Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Central 2-13, 1-1-1 Umezono, Tsukuba 305-8568 (Japan)], E-mail: nianjun.yang@iaf.fraunhofer.de

    2009-03-01

    Capillary zone electrophoresis (CZE) coupled with tris(2,2'-bipyridyl) ruthenium(II)-based end-column electrogenerated chemiluminescence (ECL) has been utilized to detect bisoprolol in drugs and tablets after its separation from metoprolol. Tetrahydrofuran was used as an additive in the running buffer to obtain the absolute ECL peak of bisoprolol. Bisoprolol reacts as a co-reactant in tris(2,2'-bipyridyl) ruthenium(II) ECL system. Under the optimized experimental conditions, bisoprolol was separated successfully and efficiently from metoprolol and other co-existed materials in tablets and urine samples. The ECL intensity of tris(2,2'-bipyridyl) ruthenium(II)-bisoprolol-based system is linear with the concentration of bisoprolol from 1.5 {mu}M to 0.3 mM with a detection limit of 0.3 {mu}M. Relative standard derivations of the ECL intensity are 2.58% for the detection of 15 {mu}M bisoprolol. This method is a simple, rapid, selective, and sensitive. It was applied successfully for the monitoring of bisoprolol in market available tablets and human urine samples.

  13. Artificial neural network based calibrations for the prediction of galactic [N II] λ6584 and Hα line luminosities

    Science.gov (United States)

    Teimoorinia, Hossein; Ellison, Sara L.

    2014-04-01

    The artificial neural network (ANN) is a well-established mathematical technique for data prediction, based on the identification of correlations and pattern recognition in input training sets. We present the application of ANNs to predict the emission line luminosities of Hα and [N II] λ6584 in galaxies. These important spectral diagnostics are used for metallicities, active galactic nuclei (AGN) classification and star formation rates, yet are shifted into the infrared for galaxies above z ˜ 0.5, or may not be covered in spectra with limited wavelength coverage. The ANN is trained with a large sample of emission line galaxies selected from the Sloan Digital Sky Survey (SDSS) using various combinations of emission lines and stellar mass. The ANN is tested for galaxies dominated by both star formation and AGN; in both cases the Hα and [N II] λ6584 line luminosities can be predicted with a scatter σ Galaxy Mass and Assembly Survey). We demonstrate the application of our line luminosities to the determination of gas-phase metallicities and AGN classification. The ANN technique yields a significant improvement in the measurement of metallicities that require [N II] and Hα when compared with the function-based conversions of Kewley & Ellison. The AGN classification is successful for 86 per cent of SDSS galaxies.

  14. DNA interaction, antimicrobial studies of newly synthesized copper (II) complexes with 2-amino-6-(trifluoromethoxy)benzothiazole Schiff base ligands.

    Science.gov (United States)

    Rambabu, Aveli; Pradeep Kumar, Marri; Tejaswi, Somapangu; Vamsikrishna, Narendrula; Shivaraj

    2016-12-01

    Four novel Schiff base ligands, L(1) (1-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)naphthalen-2-ol, C19H11F3N2O2S), L(2) (3-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)benzene-1,2-diol, C15H9F3N2O3S), L(3) (2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-5-methoxyphenol, C16H11F3N2O3S) and L(4) (2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4-bromophenol, C15H8BrF3N2O2S) and their binary copper(II) complexes 1 [Cu(L(1))2], 2 [Cu(L(2))2], 3 [Cu(L(3))2] and 4 [Cu(L(4))2] have been synthesized and characterized by elemental analysis, (1)H NMR, (13)C NMR, ESI mass, FT-IR, ESR, UV-Visible, magnetic susceptibility, TGA, SEM and powder XRD studies. Based on spectral and analytical data, a square planar geometry is assigned for all Cu(II) complexes. The ligands and their Cu(II) complexes have been screened for antimicrobial activity against bacterial species E. coli, P. aeruginosa, B. amyloliquefaciens and S. aureus and fungal species S. rolfsii and M. phaseolina and it is observed that all Cu(II) complexes are more potent than corresponding ligands. DNA binding (UV absorption, fluorescence and viscosity titrations) and cleavage (oxidative and photo cleavage) studies of Cu(II) complexes have also been investigated against calf thymus DNA (CT-DNA) and supercoiled pBR322 DNA respectively. From the experimental results, it is found that the complexes bound effectively to CT-DNA through an intercalative mode and also cleaved pBR322 DNA in an efficient manner. The DNA binding and cleavage affinities of newly synthesized Cu(II) complexes are in the order of 2>1>3>4.

  15. 20 CFR 404.111 - When we consider a person fully insured based on World War II active military or naval service.

    Science.gov (United States)

    2010-04-01

    ... on World War II active military or naval service. 404.111 Section 404.111 Employees' Benefits SOCIAL... States during World War II; (b) The person died within three years after separation from service and... Quarters of Coverage Fully Insured Status § 404.111 When we consider a person fully insured based on...

  16. Synthesis of α-Amino Acids via Asymmetric Phase Transfer-Catalyzed Alkylation of Achiral Nickel(II) Complexes of Glycine-Derived Schiff Bases

    NARCIS (Netherlands)

    Belokon, Yuri N.; Bespalova, Natalia B.; Churkina, Tatiana D.; Císařová, Ivana; Ezernitskaya, Marina G.; Harutyunyan, Syuzanna R.; Hrdina, Radim; Kagan, Henri B.; Kočovský, Pavel; Kochetkov, Konstantin A.; Larionov, Oleg V.; Lyssenko, Konstantin A.; North, Michael; Polášek, Miroslav; Peregudov, Alexander S.; Prisyazhnyuk, Vladimir V.; Vyskočil, Štěpán

    2003-01-01

    Achiral, diamagnetic Ni(II) complexes 1 and 3 have been synthesized from Ni(II) salts and the Schiff bases, generated from glycine and PBP and PBA, respectively, in MeONa/MeOH solutions. The requisite carbonyl-derivatizing agents pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide (PBP) and pyridine-

  17. Synthesis of α-Amino Acids via Asymmetric Phase Transfer-Catalyzed Alkylation of Achiral Nickel(II) Complexes of Glycine-Derived Schiff Bases

    NARCIS (Netherlands)

    Belokon, Yuri N.; Bespalova, Natalia B.; Churkina, Tatiana D.; Císařová, Ivana; Ezernitskaya, Marina G.; Harutyunyan, Syuzanna R.; Hrdina, Radim; Kagan, Henri B.; Kočovský, Pavel; Kochetkov, Konstantin A.; Larionov, Oleg V.; Lyssenko, Konstantin A.; North, Michael; Polášek, Miroslav; Peregudov, Alexander S.; Prisyazhnyuk, Vladimir V.; Vyskočil, Štěpán

    2003-01-01

    Achiral, diamagnetic Ni(II) complexes 1 and 3 have been synthesized from Ni(II) salts and the Schiff bases, generated from glycine and PBP and PBA, respectively, in MeONa/MeOH solutions. The requisite carbonyl-derivatizing agents pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide (PBP) and

  18. Preparation of polyacrylnitrile (PAN)/ Manganese oxide based activated carbon nanofibers (ACNFs) for adsorption of Cadmium (II) from aqueous solution

    Science.gov (United States)

    Abdullah, N.; Yusof, N.; Jaafar, J.; Ismail, AF; Che Othman, F. E.; Hasbullah, H.; Salleh, W. N. W.; Misdan, N.

    2016-06-01

    In this work, activated carbon nanofibers (ACNFs) from precursor polyacrylnitrile (PAN) and manganese oxide (MnO2) were prepared via electrospinning process. The electrospun PAN/MnO2-based ACNFs were characterised in term of its morphological structure and specific surface area using SEM and BET analysis respectively. The comparative adsorption study of cadmium (II) ions from aqueous solution between the neat ACNFs, composite ACNFs and commercial granular activated carbon was also conducted. SEM analysis illustrated that composite ACNFs have more compact fibers with presence of MnO2 beads with smaller fiber diameter of 437.2 nm as compared to the neat ACNFs which is 575.5 nm. BET analysis elucidated specific surface area of ACNFs/MnO2 to be 67 m2/g. Under adsorption study, it was found out that Cd (II) removal by ACNFs/MnO2 was the highest (97%) followed by neat ACNFs (96%) and GAC (74%).

  19. Synthesis, crystal structure and luminescent properties of some Zn(II) Schiff base complexes: experimental and computational study.

    Science.gov (United States)

    Eltayeb, Naser Eltaher; Teoh, Siang Guan; Adnan, Rohana; Teh, Jeannie Bee-Jan; Fun, Hoong-Kun

    2011-07-01

    A series of Zn(II)-Schiff bases I, II and III complexes were synthesized by reaction of o-phenylenediamine with 3-methylsalicylaldehyde, 4-methylsalicylaldehyde and 5-methylsalicylaldehyde. These complexes were characterized using FT-IR, UV-Vis, Diffuse reflectance UV-Vis, elemental analysis and conductivity. Complex III was characterized by XRD single crystal, which crystallizes in the triclinic system, space group P-1, with lattice parameters a=9.5444(2) Å, b=11.9407(2) Å, c=21.1732(3) Å, V=2390.24(7) Å(3), D ( c )=1.408 Mg m(-3), Z=4, F(000)=1050, GOF=0.981, R1=0.0502, wR2=0.1205. Luminescence property of these complexes was investigated in DMF solution and in the solid state. Computational study of the electronic properties of complex III showed good agreement with the experimental data.

  20. BIOSORPTION OF LEAD (II ON MODIFIED BARKS EXPLAINED BY THE HARD AND SOFT ACIDS AND BASES (HSAB THEORY

    Directory of Open Access Journals (Sweden)

    Cedric Astier,

    2012-01-01

    Full Text Available Chemical modification of Douglas fir bark and its subsequent utilization in adsorption of Pb(II from aqueous solutions was investigated. The polysaccharidic moiety of barks was functionalized by periodate oxidation and derivatized after reductive amination in the presence of aminated oligo-carrageenans. Pb(II adsorption isotherms of derivatized barks were then determined and compared to the capabilities of crude barks using the Langmuir adsorption model in terms of affinity (b and maximum binding capacity (qmax. Compared to crude barks, the derivatization of barks by oligo-carrageenans resulted in significant enhancements of qmax and b by up to x8 and x4, respectively. The results obtained from crude barks on chemically grafted carboxylic and sulfated barks are discussed and interpreted through the Hard and Soft Acids and Bases (HSAB theory.

  1. Sensitivity Analysis of Uncertainty Parameter based on MARS-LMR Code on SHRT-45R of EBR II

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Seok-Ju; Kang, Doo-Hyuk; Seo, Jae-Seung [System Engineering and Technology Co., Daejeon (Korea, Republic of); Bae, Sung-Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Jeong, Hae-Yong [Sejong University, Seoul (Korea, Republic of)

    2016-10-15

    In order to assess the uncertainty quantification of the MARS-LMR code, the code has been improved by modifying the source code to accommodate calculation process required for uncertainty quantification. In the present study, a transient of Unprotected Loss of Flow(ULOF) is selected as typical cases of as Anticipated Transient without Scram(ATWS) which belongs to DEC category. The MARS-LMR input generation for EBR II SHRT-45R and execution works are performed by using the PAPIRUS program. The sensitivity analysis is carried out with Uncertainty Parameter of the MARS-LMR code for EBR-II SHRT-45R. Based on the results of sensitivity analysis, dominant parameters with large sensitivity to FoM are picked out. Dominant parameters selected are closely related to the development process of ULOF event.

  2. Interaction of a copper(II)-Schiff base complexes with calf thymus DNA and their antimicrobial activity.

    Science.gov (United States)

    Sabolová, D; Kožurková, M; Plichta, T; Ondrušová, Z; Hudecová, D; Simkovič, M; Paulíková, H; Valent, A

    2011-03-01

    The interaction of a copper complexes containing Schiff bases with calf thymus (CT) DNA was investigated by spectroscopic methods. UV-vis, fluorescence and CD spectroscopies were conducted to assess their binding ability with CT DNA. The binding constants K have been estimated from 0.8 to 9.1×10(4) M(-1). The percentage of hypochromism is found to be over 70% (from spectral titrations). The results showed that the copper(II) complexes could bind to DNA with an intercalative mode. Synergic action of Cu(II) complexes with ascorbic acid against Candida albicans induced the generation of free radicals and increased (more than 60 times) antimicrobial effect of these complexes.

  3. Highly sensitive sensing of zinc(II) by development and characterization of a PVC-based fluorescent chemical sensor

    Science.gov (United States)

    Aksuner, Nur; Henden, Emur; Yenigul, Berrin; Yilmaz, Ibrahim; Cukurovali, Alaaddin

    2011-03-01

    A sensor membrane with excellent performance based on 1-methyl-1-phenyl-3-[1-hydroxyimino-2-(succinimido)ethyl]cyclobutane has been developed for the determination of zinc(II) ions. The sensing membrane is capable of determining zinc(II) with an outstanding high selectivity over a dynamic range between 8.0 × 10 -8 and 1.6 × 10 -4 mol L -1 with a limit of detection of 2.5 × 10 -8 mol L -1 (1.6 μg L -1). It can be easily and completely regenerated by using 0.1 mol L -1 EDTA solution. The optical sensor developed here was found to be stable, cost effective, easy to prepare, and has unique selectivity towards Zn 2+ ion with respect to common metal ions. The proposed sensor was then applied for the determination of zinc in tap water and hair samples with satisfactory results.

  4. An FPGA-based trigger for the phase II of the MEG experiment

    Energy Technology Data Exchange (ETDEWEB)

    Baldini, A. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Bemporad, C.; Cei, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Dipartimento di Fisica, Università di Pisa (Italy); Galli, L.; Grassi, M.; Morsani, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Nicolò, D., E-mail: donato.nicolo@pi.infn.it [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Dipartimento di Fisica, Università di Pisa (Italy); Ritt, S. [Paul Scherrer Institut, Villigen AG (Switzerland); Venturini, M. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Scuola Normale Superiore, Pisa (Italy)

    2016-07-11

    For the phase II of MEG, we are going to develop a combined trigger and DAQ system. Here we focus on the former side, which operates an on-line reconstruction of detector signals and event selection within 450 μs from event occurrence. Trigger concentrator boards (TCB) are under development to gather data from different crates, each connected to a set of detector channels, to accomplish higher-level algorithms to issue a trigger in the case of a candidate signal event. We describe the major features of the new system, in comparison with phase I, as well as its performances in terms of selection efficiency and background rejection. - Highlights: • A new, two-level trigger scheme for the phase-II of the MEG experiment is presented. • Improvements with respect to phase-I are underlined. • The role of detector upgrades and the use of a new generation of FPGA as well are emphasized.

  5. Thermotropic ruthenium(II)-containing metallomesogens based on substituted 1,10-phenanthroline ligands.

    Science.gov (United States)

    Cardinaels, Thomas; Ramaekers, Jan; Driesen, Kris; Nockemann, Peter; Van Hecke, Kristof; Van Meervelt, Luc; Goderis, Bart; Binnemans, Koen

    2009-03-16

    Imidazo[4,5-f]-1,10-phenanthroline and pyrazino[2,3-f]-1,10-phenanthroline substituted with long alkyl chains are versatile ligands for the design of metallomesogens because of the ease of ligand substitution. Whereas the ligands and the corresponding rhenium(I) complexes were not liquid-crystalline, mesomorphism was observed for the corresponding ionic ruthenium(II) complexes with chloride, hexafluorophosphate, and bistriflimide counterions. The mesophases were identified as smectic A phases by high-temperature small-angle X-ray scattering (SAXS) using synchrotron radiation. The transition temperatures depend on the anion, the highest temperatures being observed for the chloride salts and the lowest for the bistriflimide salts. The ruthenium(II) complexes are examples of luminescent ionic liquid crystals.

  6. FPGA Implementation of Deblocking Filter Custom Instruction Hardware on NIOS - II Based SOC

    Directory of Open Access Journals (Sweden)

    Bolla Leela Naresh

    2011-12-01

    Full Text Available This paper presents a frame work for hardware acceleration for post video processing system implemented on FPGA. The deblocking filter algorithms ported on SOC having Alter a NIOS-II soft core processor.SOC designed with the help of SOPC builder .Custom instructions are chosen by identifying the most frequently used tasks in the algorithm and the instruction set of NIOS-II processor has been extended. Deblocking filter new instruction added to the processor that are implemented in hardware and interfaced to the NIOSII processor. New instruction added to the processor to boost the performance of the deblocking filter algorithm. Use of custom instructions the implemented tasks have been accelerated by 5.88%. The benefit of the speed is obtained at the cost of very small hardware resources.

  7. FPGA Implementation of Deblocking Filter Custom Instruction Hardware on NIOS - II Based SOC

    Directory of Open Access Journals (Sweden)

    Addanki Purna Ramesh

    2012-01-01

    Full Text Available This paper presents a frame work for hardware acceleration for post video processing system implemented on FPGA. The deblocking filter algorithms ported on SOC having Altera NIOS-II soft core processor.SOC designed with the help of SOPC builder .Custom instructions are chosen by identifying the most frequently used tasks in the algorithm and the instruction set of NIOS-II processor has been extended. Deblockingfilter new instruction added to the processor that are implemented in hardware and interfaced to the NIOSII processor. New instruction added to the processor to boost the performance of the deblocking filteralgorithm. Use of custom instructions the implemented tasks have been accelerated by 5.88%. The benefit of the speed is obtained at the cost of very small hardware resources.

  8. Preparation and characterization of Zn(II ion-imprinted polymer based on salicylic acrylate for recovery of Zn(II ions

    Directory of Open Access Journals (Sweden)

    Ebrahim Ahmadi

    Full Text Available Abstract This work describes the synthesis of new ion-imprinted polymers (IIPs for selective solid phase extraction of Zn(II ions from aqueous samples. IIPs were synthesized by copolymerization of salicylic acrylate (SA as a functional monomer and ethylene glycol dimethacrylate (EGDMA as a crosslinker in the presence of 2,2’-azobisisobutyronitrile (AIBN as an initiator. The template ions were removed from IIPs particles by leaching with 0.1 M Ethylenediaminetetraacetic acid (EDTA which leaves cavities in the particles with the capability of selective extraction of the Zn(II ions. The monomer and the polymer after synthesis have been characterized by 1H NMR, 13C NMR and FT-IR studies. The effect of the pH on the extraction efficiency of Zn(II ions was studied and optimized in pH around 6. The selectivity of the synthesized IIPs was studied in the presence of Co(II, Cd(II and Ni(II ions, and the IIPs showed higher affinity for Zn(II in the presence of other interfering ions.

  9. A new copper(II) Schiff base complex containing asymmetrical tetradentate N2O2 Schiff base ligand: Synthesis, characterization, crystal structure and DFT study

    Science.gov (United States)

    Grivani, Gholamhossein; Baghan, Sara Husseinzadeh; Vakili, Mohammad; Khalaji, Aliakbar Dehno; Tahmasebi, Vida; Eigner, Václav; Dušek, Michal

    2015-02-01

    A new copper (II) Schiff base complex, CuL1, was prepared from the reaction of asymmetrical Schiff base ligand of L1 and Cu(OAC)2 (L1 = salicylidene imino-ethylimino-pentan-2-one). The Schiff base ligand, L1, and its copper (II) complex, CuL1, have been characterized by elemental analysis (CHN) and FT-IR and UV-vis spectroscopy. In addition, 1H NMR was employed for characterization of the ligand. Thermogrametric analysis of the CuL1 reveals its thermal stability and its decomposition pattern shows that it is finally decomposed to the copper oxide (CuO). The crystal structure of CuL1 was determined by the single crystal X-ray analysis. The CuL1 complex crystallizes in the monoclinic system, with space group P21/n and distorted square planar coordination around the metal ion. The Schiff base ligand of L1 acts as a chelating ligand and coordinates via two nitrogen and two oxygen atoms to the copper (II) ion with C1 symmetry. The structure of the CuL1 complex was also studied theoretically at different levels of DFT and basis sets. According to calculated results the Csbnd O bond length of the salicylate fragment is slightly higher than that in the acetylacetonate fragment of ligand, which could be interpreted by resonance increasing between phenyl and chelated rings in ligand in relative to the acetylacetonate fragment.

  10. Hg(II Coordination Polymers Based on N,N’-bis(pyridine-4-ylformamidine

    Directory of Open Access Journals (Sweden)

    Wayne Hsu

    2016-04-01

    Full Text Available Reactions of N,N’-bis(pyridine-4-ylformamidine (4-Hpyf with HgX2 (X = Cl, Br, and I afforded the formamidinate complex {[Hg(4-pyf2]·(THF}n, 1, and the formamidine complexes {[HgX2(4-Hpyf]·(MeCN}n (X = Br, 2; I, 3, which have been structurally characterized by X-ray crystallography. Complex 1 is a 2D layer with the {44·62}-sql topology and complexes 2 and 3 are helical chains. While the helical chains of 2 are linked through N–H···Br hydrogen bonds, those of 3 are linked through self-complementary double N–H···N hydrogen bonds, resulting in 2D supramolecular structures. The 4-pyf- ligands of 1 coordinate to the Hg(II ions through one pyridyl and one adjacent amine nitrogen atoms and the 4-Hpyf ligands of 2 and 3 coordinate to the Hg(II ions through two pyridyl nitrogen atoms, resulting in new bidentate binding modes. Complexes 1–3 provide a unique opportunity to envisage the effect of the halide anions of the starting Hg(II salts on folding and unfolding the Hg(II coordination polymers. Density function theory (DFT calculation indicates that the emission of 1 is due to intraligand π→π * charge transfer between two different 4-pyf- ligands, whereas those of 2 and 3 can be ascribed to the charge transfer from non-bonding p-type orbitals of the halide anions to π * orbitals of the 4-pyf- ligands (n→π *. The gas sorption properties of the desolvated product of 1 are compared with the Cu analogues to show that the nature of the counteranion and the solvent-accessible volume are important in determining their adsorption capability.

  11. New cobalt(II) and nickel(II) complexes of benzyl carbazate Schiff bases: Syntheses, crystal structures, in vitro DNA and HSA binding studies.

    Science.gov (United States)

    Nithya, Palanivelu; Helena, Sannasi; Simpson, Jim; Ilanchelian, Malaichamy; Muthusankar, Aathi; Govindarajan, Subbiah

    2016-12-01

    In the present study, new Schiff base complexes with the composition [M(NCS)2(L1)2]·nH2O, where M=Co (n=0) (1) and Ni (n=2) (2); [M(NCS)2(L2)2], M=Co (3) and Ni (4) as well as [M(NCS)2(L3)2], M=Co (5) and Ni (6); (L1=benzyl 2-(propan-2-ylidene)hydrazinecarboxylate, L2=benzyl 2-(butan-2-ylidene)hydrazinecarboxylate and L3=benzyl 2-(pentan-3-ylidene)hydrazinecarboxylate) have been synthesized by a template method. The complexes were characterised by analytical methods, spectroscopic studies, thermal and X-ray diffraction techniques. The structures of all the complexes explore that the metal(II) cation has a trans-planar coordination environment, the monomeric units containing a six-coordinated metal center in octahedral geometry with N-bound isothiocyanate anions coordinated as terminal ligands. Furthermore, the binding of the two Schiff base ligands to the metal centers involves the azomethine nitrogen and the carbonyl oxygen in mutually trans configuration. The binding interactions of all the complexes with Calf thymus-deoxyribonucleic acid (CT-DNA) and human serum albumin (HSA) have been investigated using absorption and emission spectral techniques. The CT-DNA binding properties of these complexes reveal that they bind to CT-DNA through a partial intercalation mode and the binding constant values were calculated using the absorption and emission spectral data. The binding constant values (~10×10(6)moldm(-3)) indicate strong binding of metal complexes with CT-DNA. HSA binding interaction studies showed that the cobalt and nickel complexes can quench the intrinsic fluorescence of HSA through static quenching process. Also, molecular docking studies were supported out to apprehend the binding interactions of these complexes with DNA and HSA which offer new understandings into the experimental model observations.

  12. Silica functionalized Cu(II) acetylacetonate Schiff base complex: An efficient catalyst for the oxidative condensation reaction of benzyl alcohol with amines

    Science.gov (United States)

    Anbarasu, G.; Malathy, M.; Karthikeyan, P.; Rajavel, R.

    2017-09-01

    Silica functionalized Cu(II) acetylacetonate Schiff base complex via the one pot reaction of silica functionalized 3-aminopropyltriethoxysilane with acetyl acetone and copper acetate has been reported. The synthesized material was well characterized by analytical techniques such as FT-IR, UV-DRS, XRD, SEM-EDX, HR-TEM, EPR, ICP-AES and BET analysis. The characterization results confirmed the grafting of Cu(II) Schiff base complex on the silica surface. The catalytic activity of synthesized silica functionalized Cu(II) acetylacetonate Schiff base complex was evaluated through the oxidative condensation reaction of benzyl alcohol to imine.

  13. Multi-objective Optimization of Coal-fired Boiler Combustion Based on NSGA-II

    Directory of Open Access Journals (Sweden)

    Tingfang Yu

    2013-06-01

    Full Text Available NOx emission characteristics and overall heat loss model for a 300MW coal-fired boiler were established by Back Propagation (BP neural network, by which the the functional relationship between outputs (NOx emissions & overall heat loss of the boiler and inputs (operational parameters of the boiler of a coal-fired boiler can be predicted. A number of field test data from a full-scale operating 300MWe boiler were used to train and verify the BP model. The NOx emissions & heat loss predicted by the BP neural network model showed good agreement with the measured. Then, BP model and the non-dominated sorting genetic algorithm II (NSGA-II were combined to gain the optimal operating parameters which lead to lower NOx emissions and overall heat loss boiler. The optimization results showed that hybrid algorithm by combining BP neural network with NSGA-II can be a good tool to solve the problem of multi-objective optimization of a coal-fired combustion, which can reduce NOx emissions and overall heat loss effectively for the coal-fired boiler.

  14. Preparation and Characterization of Bi-metallic and Tri-metallic Metal Organic Frameworks Based on Trimesic Acid and Co(II), Ni(II), and Cu(II) Ions

    Science.gov (United States)

    Sahiner, Nurettin; Demirci, Sahin; Yildiz, Mustafa

    2016-10-01

    Trimesic acid-M1(II):M2(II) (M1,2(II)=M(II)=Co(II), Ni(II) and Cu(II)) bi-metallic or tri-metallic organic frameworks (MOFs) were synthesized by the reaction of trimesic acid (H3BTC) ligand with the corresponding MCl2nH2O aqueous solutions. Here, bi- and tri-metallic MOF preparations were demonstrated by using H3BTC as an organic linker, with dual metal ion mixtures at different mole ratios such as Co(II):Ni(II), Ni(II):Cu(II), and Cu(II):Co(II) as metal ion sources in the synthesis of bi-metallic MOFs, and the triple metal ion mixture of Co(II):Ni(II):Cu(II) as the metal ion source in the synthesis of tri-metallic MOFs. The bi- or tri-metallic MOFs were characterized via the Brunauer-Emmett-Teller method, thermogravimetric analyzer (TGA), and magnetic susceptibility measurements with the Gouy method, FT-IR spectroscopy, and electronic spectral studies. The results revealed that the H3BTC MOFs have octahedral and distorted octahedral arrangement around the metal ions, and the d-d transition was not observed in the complex. It was further found that all the prepared MOFs contain water molecules confirmed by Fourier transform infrared (FT-IR) and TGA analyses. The FT-IR spectra of the MOF complexes were characterized by the appearance of a broad band in the region of 3454-3300 cm-1 due to the ν(-OH) of the coordinated water; therefore, the location of the two water molecules was assumed to be inside the complex structure. Remarkably, the synthesized bi-metallic MOFs had unique and distinct colors depending on the amounts of metal ions used in the feed, implying that these bi-metallic MOFs with tunable M1(II) and M2(II) ratios offer great potential in the design of color-coded materials for use as sensors.

  15. Preparation and Characterization of Bi-metallic and Tri-metallic Metal Organic Frameworks Based on Trimesic Acid and Co(II), Ni(II), and Cu(II) Ions

    Science.gov (United States)

    Sahiner, Nurettin; Demirci, Sahin; Yildiz, Mustafa

    2017-02-01

    Trimesic acid-M1(II):M2(II) (M1,2(II)=M(II)=Co(II), Ni(II) and Cu(II)) bi-metallic or tri-metallic organic frameworks (MOFs) were synthesized by the reaction of trimesic acid (H3BTC) ligand with the corresponding MCl2nH2O aqueous solutions. Here, bi- and tri-metallic MOF preparations were demonstrated by using H3BTC as an organic linker, with dual metal ion mixtures at different mole ratios such as Co(II):Ni(II), Ni(II):Cu(II), and Cu(II):Co(II) as metal ion sources in the synthesis of bi-metallic MOFs, and the triple metal ion mixture of Co(II):Ni(II):Cu(II) as the metal ion source in the synthesis of tri-metallic MOFs. The bi- or tri-metallic MOFs were characterized via the Brunauer-Emmett-Teller method, thermogravimetric analyzer (TGA), and magnetic susceptibility measurements with the Gouy method, FT-IR spectroscopy, and electronic spectral studies. The results revealed that the H3BTC MOFs have octahedral and distorted octahedral arrangement around the metal ions, and the d-d transition was not observed in the complex. It was further found that all the prepared MOFs contain water molecules confirmed by Fourier transform infrared (FT-IR) and TGA analyses. The FT-IR spectra of the MOF complexes were characterized by the appearance of a broad band in the region of 3454-3300 cm-1 due to the ν(-OH) of the coordinated water; therefore, the location of the two water molecules was assumed to be inside the complex structure. Remarkably, the synthesized bi-metallic MOFs had unique and distinct colors depending on the amounts of metal ions used in the feed, implying that these bi-metallic MOFs with tunable M1(II) and M2(II) ratios offer great potential in the design of color-coded materials for use as sensors.

  16. DNA binding, BSA interaction and SOD activity of two new nickel(II) complexes with glutamine Schiff base ligands.

    Science.gov (United States)

    Wei, Qiang; Dong, Jianfang; Zhao, Peiran; Li, Manman; Cheng, Fengling; Kong, Jinming; Li, Lianzhi

    2016-08-01

    Two hexacoordinated octahedral nickel(II) complexes, [Ni(o-van-gln)(phen)(H2O)](1) and [Ni(sal-gln)(phen)(H2O)](2) [o-van-gln=a Schiff base derived from o-vanillin and glutamine, sal-gln=a Schiff base derived from salicylaldehyde and glutamine, phen=1,10-phenanthroline], have been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffraction. X-ray studies showed that nickel atoms of both 1 and 2 exhibit distorted NiN3O3 octahedral geometry. In each crystal, intermolecular hydrogen bonds form a two-dimensional network structure. DNA-binding properties of these two nickel(II) complexes were investigated by using UV-Vis absorption, fluorescence, circular dichroism (CD) spectroscopies and viscosity measurements. Results indicated that the two complexes can bind to calf thymus DNA (CT-DNA) via an intercalative mode, and complex 1 exhibits higher interaction with CT-DNA than complex 2. Furthermore, the interactions between the nickel(II) complexes with bovine serum albumin (BSA) have been studied by spectroscopies. The results indicated that both complexes could quench the intrinsic fluorescence of BSA in a static quenching process. The binding constants (Kb) and the numbers of binding sites (n) obtained are 1.10×10(5)M(-1) and 1.05 for complex 1 and 5.05×10(4)M(-1) and 0.997 for complex 2, respectively. Site-selective competitive binding investigation indicated that the binding sites of both the complexes are located in site I of sub-domains IIA of BSA. Assay of superoxide dismutase (SOD) activity of the nickel(II) complexes revealed that they exhibit significant superoxide scavenging activity with IC50=3.4×10(-5)M for complex 1 and 4.3×10(-5)M for complex 2, respectively.

  17. Structures and Magnetic Properties of Monomeric Copper(II) Bromide Complexes with a Pyridine-Containing Tridentate Schiff Base

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sung Kwon [Chungnam National Univ., Daejeon (Korea, Republic of); Yong, Soon Jung; Song, Young Kwang; Kim, Young Inn [Pusan National Univ., Busan (Korea, Republic of)

    2013-12-15

    Two novel copper(II) bromide complexes with pyridine containing Schiff base ligands, Cu(pmed)Br{sub 2} and Cu(dpmed)Br{sub 2} where pmed = N'-((pyridin-2-yl)methylene)ethane-1,2-diamine (pmed) and dpmed = N,N-diethyl-N'-((pyridin-2-yl)methylene)ethane-1,2-diamine (dpmed) were synthesized and characterized using Xray single crystal structure analysis, optical and magnetic susceptibility measurements. Crystal structural analysis of Cu(pmed)Br{sub 2} showed that the copper(II) ion has a distorted square-pyramidal geometry with the trigonality index of τ = 0.35 and two intermolecular hydrogen bonds, which result in the formation of two dimensional networks in the ab plane. On the other hand, Cu(dpmed)Br{sub 2} displayed a near square-pyramidal geometry with the value of τ = 0.06. In both compounds, the NNN Schiff base and one Br atom occupy the basal plane, whereas the fifth apical position is occupied by the other Br atom at a greater Cu-Br apical distance. The reported complexes show g{sub Π} > g{sub Τ} > 2.0023 with a d{sub x2-y2} ground state and a penta-coordinated square pyramidal geometry. Variable temperature magnetic susceptibility measurements showed that the developed copper(II) complexes follow the Curie-Weiss law, that is there are no magnetic interactions between the copper(II) ions since the Cu--Cu distance is too far for magnetic contact.

  18. HOMO- AND HETERONUCLEAR COMPLEXES OF COPPER (II WITH SCHIFF BASE OBTAINED ON THE BASE OF 2-HYDROXY-3-CARBOXYNAPHTALDEHYDE

    Directory of Open Access Journals (Sweden)

    A.G. Lazarescu

    2006-06-01

    Full Text Available The complexes of general formula Cu(H2L (II; [CuLn(L(NO3(H2On] (where H4L=N,NI-bis[2- hydroxy(3-carboxynaphtalidene]ethylenediamine; Ln: Nd, n=6 (III; Eu, n=4 (IV; Gd, n=6 (V have been synthesized and investigated by different methods (IR spectroscopy, TG analysis and magnetochemistry. The coordination set of complex generators are Cu(N2O2 and Ln(O8-9. The effective magnetic moment values, μeff, at 300 K are: 1.78 (II, 3.22 (III, 6.44 (V B.M. The temperature dependence (300-2 K of magnetic susceptibility of [CuNd(L(NO3(H2O6] indicates the antiferromagnetic interaction between metal ions.

  19. Synthesis, characterization, X-ray crystal structures and antibacterial activities of Schiff base ligands derived from allylamine and their vanadium(IV), cobalt(III), nickel(II), copper(II), zinc(II) and palladium(II) complexes

    Science.gov (United States)

    Amiri Rudbari, Hadi; Iravani, Mohammad Reza; Moazam, Vahid; Askari, Banafshe; Khorshidifard, Mahsa; Habibi, Neda; Bruno, Giuseppe

    2016-12-01

    A new Schiff base ligand, HL2, and four new Schiff base complexes, NiL12, PdL12, NiL22 and ZnL22, have been prepared and characterized by elemental analysis (CHN), FT-IR and UV-Vis spectroscopy. 1H and 13C NMR techniques were employed for characterization of the ligand (HL2) and the diamagnetic complexes (PdL12 and ZnL22). The molecular structures of PdL12, NiL22 and ZnL22 complexes were determined by the single crystal X-ray diffraction technique. The crystallographic data reveal that in these complexes the metal centers are four-coordinated by two phenolate oxygen and two imine nitrogen atoms of two Schiff base ligands. The geometry around the metal center in the PdL12 and NiL22 complexes is square-planar and for ZnL22 it is a distorted tetrahedral.In the end, five new (HL2, NiL12, PdL12, NiL22 and ZnL22) and six reported (HL1, VOL12, CoL13, CuL12, ZnL12 and Zn2L14) Schiff base compounds were tested for their in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli as examples of Gram-positive and Gram-negative bacterial strains, respectively, by disc diffusion method.

  20. Synthesis and characterization of a series of transition metal complexes with a new symmetrical polyoxaaza macroacyclic Schiff base ligand: X-ray crystal structure of cobalt(II) and nickel(II) complexes and their antibacterial properties.

    Science.gov (United States)

    Keypour, Hassan; Shayesteh, Maryam; Rezaeivala, Majid; Chalabian, Firoozeh; Valencia, Laura

    2013-01-15

    A new symmetrical [N4O2] hexadentate Schiff base ligand, (E)-N-(pyridin-2-ylmethylene)-2-(3-(2-((E)-pyridin-2-lmethyleneamino)phenoxy)naphthalen-2-yloxy)benzenamine, abbreviated to L, and its complexes of Ni(II), Cu(II), Zn(II), Co(II), Cd(II) and Mn(II) have been synthesized in the presence of metal ions. The complexes were structurally characterized by elemental analyses, IR, UV-Vis, NMR and molar conductivity. The crystal structures of two complexes, [NiL(ONO2)2]·2H2O and [CoLCl2]CH3OH·0.5H2O, have been determined by a single crystal X-ray diffraction study. In these complexes, the ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms. The metal ions complete their six coordination with two coordinated nitrate or chloride ions, forming a distorted octahedral geometry. The synthesized compounds have antibacterial activity against the three Gram-positive bacteria: Enterococcus faecalis, Bacillus cereus and Staphylococcus epid and also against the three Gram-negative bacteria: Citrobacter freundii, Enterobacter aerogenes and Salmonella typhi. The activity data show that the complexes are more potent antibacterials than the parent Schiff base.

  1. Synthesis and characterization of a series of transition metal complexes with a new symmetrical polyoxaaza macroacyclic Schiff base ligand: X-ray crystal structure of cobalt(II) and nickel(II) complexes and their antibacterial properties

    Science.gov (United States)

    Keypour, Hassan; Shayesteh, Maryam; Rezaeivala, Majid; Chalabian, Firoozeh; Valencia, Laura

    2013-01-01

    A new symmetrical [N4O2] hexadentate Schiff base ligand, (E)-N-(pyridin-2-ylmethylene)-2-(3-(2-((E)-pyridin-2-lmethyleneamino)phenoxy)naphthalen-2-yloxy)benzenamine, abbreviated to L, and its complexes of Ni(II), Cu(II), Zn(II), Co(II), Cd(II) and Mn(II) have been synthesized in the presence of metal ions. The complexes were structurally characterized by elemental analyses, IR, UV-Vis, NMR and molar conductivity. The crystal structures of two complexes, [NiL(ONO2)2]·2H2O and [CoLCl2]CH3OH·0.5H2O, have been determined by a single crystal X-ray diffraction study. In these complexes, the ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms. The metal ions complete their six coordination with two coordinated nitrate or chloride ions, forming a distorted octahedral geometry. The synthesized compounds have antibacterial activity against the three Gram-positive bacteria: Enterococcus faecalis, Bacillus cereus and Staphylococcus epid and also against the three Gram-negative bacteria: Citrobacter freundii, Enterobacter aerogenes and Salmonella typhi. The activity data show that the complexes are more potent antibacterials than the parent Schiff base.

  2. Synthesis of Two Potentially Heptadentate (N4O3 Schiff-base Ligands Derived from Condensation of Tris(3-aminopropyl-amine and Salicylaldehyde or 4-Hydroxysalicylaldehyde. Nickel(II and Copper(II Complexes of the Former Ligand

    Directory of Open Access Journals (Sweden)

    R. V. Parish

    2002-02-01

    Full Text Available Two potentially heptadentate (N4O3 tripodal Schiff-base ligands: tris(3-(salicylideneiminopropylamine (H3L1 and tris(3-(4’-hydroxysalicylideneimino-propylamine (H3L2 have been prepared and characterized by various spectroscopic methods (IR, FAB-MS, NMR. They are derived from the condensation reactions of tris(3-aminopropylamine (tpt, with 3 equivalents of either salicylaldehyde or the ringsubstituted salicylaldehyde, 4-hydroxysalicylaldehyde. The nickel(II and copper(II complexes of H3L1 were obtained from the its reactions Ni(II and Cu(II salts in absolute methanol. These complexes were studied by IR and FAB-Mass spectrometry.

  3. Fluorescence Lifetime Imaging of Physiological Free Cu(II) Levels in Live Cells with a Cu(II)-Selective Carbonic Anhydrase-Based Biosensor

    Science.gov (United States)

    McCranor, Bryan J.; Szmacinski, Henryk; Zeng, Hui Hui; Stoddard, A.K.; Hurst, Tamiika; Fierke, Carol A.; Lakowicz, J.R.

    2014-01-01

    Copper is a required trace element that plays key roles in a number of human enzymes, such that copper deficiency or genetic defects in copper transport lead to serious or fatal disease. Rae, et al., had famously predicted that free copper ion levels in the cell cytoplasm were extremely low, typically too low to be observable. We recently developed a variant of human apocarbonic anhydrase II for sensing metal ions that exhibits 25-fold better selectivity for Cu(II) over Zn(II) than the wild type protein, enabling us to accurately measure Cu(II) in the presence of ordinary cellular (picomolar) concentrations of free zinc. We inserted a fluorescent labeled Cu(II)-specific variant of human apocarbonic anhydrase into PC-12 cells and found that the levels are indeed extremely low (in the femtomolar range). We imaged the free Cu(II) levels in living cells by means of frequency-domain fluorescence lifetime microscopy. Implications of this finding are discussed. PMID:24671220

  4. The NeuARt II system: a viewing tool for neuroanatomical data based on published neuroanatomical atlases

    Directory of Open Access Journals (Sweden)

    Cheng Wei-Cheng

    2006-12-01

    Full Text Available Abstract Background Anatomical studies of neural circuitry describing the basic wiring diagram of the brain produce intrinsically spatial, highly complex data of great value to the neuroscience community. Published neuroanatomical atlases provide a spatial framework for these studies. We have built an informatics framework based on these atlases for the representation of neuroanatomical knowledge. This framework not only captures current methods of anatomical data acquisition and analysis, it allows these studies to be collated, compared and synthesized within a single system. Results We have developed an atlas-viewing application ('NeuARt II' in the Java language with unique functional properties. These include the ability to use copyrighted atlases as templates within which users may view, save and retrieve data-maps and annotate them with volumetric delineations. NeuARt II also permits users to view multiple levels on multiple atlases at once. Each data-map in this system is simply a stack of vector images with one image per atlas level, so any set of accurate drawings made onto a supported atlas (in vector graphics format could be uploaded into NeuARt II. Presently the database is populated with a corpus of high-quality neuroanatomical data from the laboratory of Dr Larry Swanson (consisting 64 highly-detailed maps of PHAL tract-tracing experiments, made up of 1039 separate drawings that were published in 27 primary research publications over 17 years. Herein we take selective examples from these data to demonstrate the features of NeuArt II. Our informatics tool permits users to browse, query and compare these maps. The NeuARt II tool operates within a bioinformatics knowledge management platform (called 'NeuroScholar' either as a standalone or a plug-in application. Conclusion Anatomical localization is fundamental to neuroscientific work and atlases provide an easily-understood framework that is widely used by neuroanatomists and non

  5. Coordination modes of a schiff base pentadentate derivative of 4-aminoantipyrine with cobalt(II), nickel(II) and copper(II) metal ions: synthesis, spectroscopic and antimicrobial studies.

    Science.gov (United States)

    Chandra, Sulekh; Jain, Deepali; Sharma, Amit Kumar; Sharma, Pratibha

    2009-01-01

    Transition metal complexes of Co(II), Ni(II) and Cu(II) metal ions with general stoichiometry [M(L)X]X and [M(L)SO(4)], where M = Co(II), Ni(II) and Cu(II), L = 3,3'-thiodipropionic acid bis(4-amino-5-ethylimino-2,3-dimethyl-1-phenyl-3-pyrazoline) and X = NO(3)(-), Cl(-) and OAc(-), have been synthesized and structurally characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements and spectral techniques like IR, UV and EPR. The nickel(II) complexes were found to have octahedral geometry, whereas cobalt(II) and copper(II) complexes were of tetragonal geometry. The covalency factor (beta) and orbital reduction factor (k) suggest the covalent nature of the complexes. The ligand and its complexes have been screened for their antifungal and antibacterial activities against three fungi, i.e. Alternaria brassicae, Aspergillus niger and Fusarium oxysporum and two bacteria, i.e. Xanthomonas compestris and Pseudomonas aeruginosa.

  6. Synthesis, characterization, DNA interaction and pharmacological studies of substituted benzophenone derived Schiff base metal(II complexes

    Directory of Open Access Journals (Sweden)

    P. Subbaraj

    2015-03-01

    Full Text Available A new bidentate NO type Schiff base ligand (HL, derived from 2-hydroxy-4-methoxyphenylphenylmethanone with aniline and its metal(II [M = Mn, Co, Ni, Cu and Zn] complexes has been synthesized. The synthesized ligand and the metal(II complexes were structurally characterized by analytical, spectral (FT-IR, UV–vis., 1H NMR, FAB-Mass, TGA/DTA and EPR as well as molar conductance and magnetic studies. All the complexes are non-electrolytes having 1:2 stoichiometry. They adopt tetrahedral and octahedral geometry. Thermal behavior of metal(II complexes (1a–1c shows loss of coordinated water molecules in the first step followed by the decomposition of ligand moieties in a respective manner and leads to form an air stable metal oxide as the final residue. Micro crystalline nature and the presence of coordinated water molecules have been confirmed by powder XRD, SEM and thermal analyses. The ligand and its complexes have efficient bio-efficacy, DNA binding and cleavage ability.

  7. Synthesis and Crystal Structure of a Dinuclear Cu(II) Complex with Tridentate Schiff Base and Azido Bridge

    Institute of Scientific and Technical Information of China (English)

    LIN Hong; FENG Yun Long; GAO Shan

    2005-01-01

    A new dinuclear copper(II) complex ([Cu(C12H17N2O)(N3)]2, C24H34Cu2N10O2) has been synthesized and characterized by X-ray structure determination. It crystallizes in the monoclinic system, space group P21/c with a = 18.529(4), b = 10.933(2), c = 14.534(3)(A),β = 111.07(3)(A), V = 2748(1)(A)3, Z = 4, Mr = 621.69, F(000) = 1288, Dc = 1.503 g/cm3 and μ(MoKα) = 1.590 mm(1. The structure was refined to R = 0.0647 and wR = 0.1846 for 4406 observed reflections (I > 2σ(I)). The asymmetric unit comprises two halfmolecules. The complex is a centrosymmetric dimmer in which the copper atoms are penta-coordinated by three coordination atoms from the corresponding tridentate Schiff base ligand and two bridging azide anions. The Cu(II)…Cu(II) average distance is 3.350(1)(A).

  8. Three 3D hybrid networks based on octamolybdates and different Cu I/Cu II-bis(triazole) motifs

    Science.gov (United States)

    Zhang, Chun-Jing; Pang, Hai-Jun; Tang, Qun; Wang, Hui-Yuan; Chen, Ya-Guang

    2010-12-01

    Three 3D compounds based on octamolybdate clusters and various Cu I/Cu II-bis(triazole) motifs, [Cu I2btb][ β-Mo 8O 26] 0.5 ( 1), [Cu I2btpe][ β-Mo 8O 26] 0.5 ( 2), and [Cu II(btpe) 2][ β-Mo 8O 26] 0.5 ( 3) [btb=1,4-bis(1,2,4-triazol-1-yl)butane, btpe=1,5-bis(1,2,4-triazol-1-yl)pentane], were isolated via tuning flexible ligand spacer length and metal coordination preferences. In 1, the copper(I)-btb motif is a one-dimensional (1D) chain which is further linked by hexadentate β-[Mo 8O 26] 4- clusters via coordinating to Cu I cations giving a 3D structure. In 2, the copper(I)-btpe motif exhibits a "stairs"-like [Cu I2btpe] 2+ sheet, and the tetradentate β-[Mo 8O 26] 4- clusters interact with two neighboring [Cu I2btpe] 2+ sheets constructing a 3D framework. In 3, the copper(II)-btpe motif possesses a novel (2D→3D) interdigitated structure, which is further connected by the tetradentate β-[Mo 8O 26] 4- clusters forming a 3D framework. The thermal stability and luminescent properties of 1- 3 are investigated in the solid state.

  9. Feature Extraction and Selection Scheme for Intelligent Engine Fault Diagnosis Based on 2DNMF, Mutual Information, and NSGA-II

    Directory of Open Access Journals (Sweden)

    Peng-yuan Liu

    2016-01-01

    Full Text Available A novel feature extraction and selection scheme is presented for intelligent engine fault diagnosis by utilizing two-dimensional nonnegative matrix factorization (2DNMF, mutual information, and nondominated sorting genetic algorithms II (NSGA-II. Experiments are conducted on an engine test rig, in which eight different engine operating conditions including one normal condition and seven fault conditions are simulated, to evaluate the presented feature extraction and selection scheme. In the phase of feature extraction, the S transform technique is firstly utilized to convert the engine vibration signals to time-frequency domain, which can provide richer information on engine operating conditions. Then a novel feature extraction technique, named two-dimensional nonnegative matrix factorization, is employed for characterizing the time-frequency representations. In the feature selection phase, a hybrid filter and wrapper scheme based on mutual information and NSGA-II is utilized to acquire a compact feature subset for engine fault diagnosis. Experimental results by adopted three different classifiers have demonstrated that the proposed feature extraction and selection scheme can achieve a very satisfying classification performance with fewer features for engine fault diagnosis.

  10. Electrochemical, catalytic and antimicrobial activities of N-functionalized cyclam based unsymmetrical dicompartmental binuclear nickel(II) complexes

    Science.gov (United States)

    Sreedaran, S.; Bharathi, K. Shanmuga; Rahiman, A. Kalilur; Suresh, R.; Jegadeesh, R.; Raaman, N.; Narayanan, V.

    2009-11-01

    Five binuclear nickel(II) complexes have been prepared by simple Schiff base condensation of the compound 1,8-[bis(3-formyl-2-hydroxy-5-bromo)benzyl]-l,4,8,11-tetraazacyclotetradecane (L) with appropriate aliphatic or aromatic diamine, nickel(II) perchlorate and triethylamine. All the complexes were characterized by elemental and spectral analysis. Positive ion FAB mass spectra show the presence of dinickel core in the complexes. The electronic spectra of the complexes show red shift in the d-d transition. Electrochemical studies of the complexes show two irreversible one electron reduction processes in the range of 0 to -1.4 V. The reduction potential of the complexes shifts towards anodically upon increasing chain length of the macrocyclic ring. All the nickel(II) complexes show two irreversible one electron oxidation waves in the range 0.4-1.6 V. The observed rate constant values for catalysis of the hydrolysis of 4-nitrophenyl phosphate are in the range of 1.36 × 10 -2-9.14 × 10 -2 min -1. The rate constant values for the complexes containing aliphatic diimines are found to be higher than the complexes containing aromatic diimines. Spectral, electrochemical and catalytic studies of the complexes were compared on the basis of increasing chain length of the imine compartment. All the complexes show higher antimicrobial activity than the ligand and metal salt.

  11. Primordial 4He abundance: a determination based on the largest sample of H II regions with a methodology tested on model H II regions

    Science.gov (United States)

    Izotov, Y. I.; Stasińska, G.; Guseva, N. G.

    2013-10-01

    We verified the validity of the empirical method to derive the 4He abundance used in our previous papers by applying it to CLOUDY (v13.01) models. Using newly published He i emissivities for which we present convenient fits as well as the output CLOUDY case B hydrogen and He i line intensities, we found that the empirical method is able to reproduce the input CLOUDY 4He abundance with an accuracy of better than 1%. The CLOUDY output data also allowed us to derive the non-recombination contribution to the intensities of the strongest Balmer hydrogen Hα, Hβ, Hγ, and Hδ emission lines and the ionisation correction factors for He. With these improvements we used our updated empirical method to derive the 4He abundances and to test corrections for several systematic effects in a sample of 1610 spectra of low-metallicity extragalactic H ii regions, the largest sample used so far. From this sample we extracted a subsample of 111 H ii regions with Hβ equivalent width EW(Hβ) ≥ 150 Å, with excitation parameter x = O2+/O ≥ 0.8, and with helium mass fraction Y derived with an accuracy better than 3%. With this subsample we derived the primordial 4He mass fraction Yp = 0.254 ± 0.003 from linear regression Y - O/H. The derived value of Yp is higher at the 68% confidence level (CL) than that predicted by the standard big bang nucleosynthesis (SBBN) model, possibly implying the existence of different types of neutrino species in addition to the three known types of active neutrinos. Using the most recently derived primordial abundances D/H = (2.60 ± 0.12) × 10-5 and Yp = 0.254 ± 0.003 and the χ2 technique, we found that the best agreement between abundances of these light elements is achieved in a cosmological model with baryon mass density Ωbh2 = 0.0234 ± 0.0019 (68% CL) and an effective number of the neutrino species Neff = 3.51 ± 0.35 (68% CL). Based on observations collected at the European Southern Observatory, Chile, programs 073.B-0283(A), 081.C-0113(A

  12. Ruthenium(II) cluster complexes: a series of homooligonuclear complexes based on bidentate bridging ligands

    Energy Technology Data Exchange (ETDEWEB)

    Sahai, R.; Morgan, L.; Rillema, D.P.

    1988-10-05

    The preparation and properties of trimetallic and tetrametallic cluster complexes containing ruthenium(II) metal centers bridged by 2,2'-bipyrimidine (bpm) and 2,3-bis(2-pyridyl)quinoxaline (bpq) are reported. The tetrametallic clusters are symmetrical complexes containing a central ruthenium(II) coordinated to three (BL)Ru(bpy)/sub 2//sup 2 +/ ligands, where BL is bpm or bpq and bpy is 2,2'-bipyridine. The trimetallic clusters are asymmetric and are of the general formula ((bpy)Ru(BLRu(bpy)/sub 2/)/sub 2/)/sup 6 +/. The complexes exhibit low-energy MLCT transitions assigned as d..pi..(Ru(outer)) ..-->.. ..pi..*(BL). The MLCT maxima of the tetrametallic complexes were at slightly higher energies than those for their trimetallic analogues. For example, lambda/sub max/ for (Ru(bpqRu(bpy)/sub 2/)/sub 3/)/sup 8 +/ was located at 618 nm; that of ((bpy)Ru(bpqRu(bpy)/sub 2/)/sub 2/)/sup 3 +/ was located at 621 nm. The E/sub 1/2/ values were determined by cyclic voltammetry. The first oxidation in the case of ((bpy)Ru(bpqRu(bpy)/sub 2/)/sub 2/)/sup 6 +/ was located at E/sub 1/2/(1) = 1.57 V, and the second, at E/sub 1/2/(2) = 1.83 V vs. SSCE. The wave associated with E/sub 1/2/(1) had about twice the peak current as the wave at E/sub 1/2/(2) and, hence, was assigned to the Ru(III/II) redox couple of the outer ruthenium(II) components. The low-energy MLCT transitions for the mononuclear precursors (Ru(bpy)/sub x/(BL)/sub 3-x/, x = 1-3) and the multimetallic complexes were found to parallel ..delta..E/sub 1/2/, the difference between E/sub 1/2/ values for the first oxidation and the first reduction. The excellent correlation (slope 1, correlation coefficient 0.99) indicates that either the energy of the lowest MLCT transition or ..delta..E/sub 1/2/ can be used to measure the energy gap between the d..pi.. and ..pi..* energy levels. 32 references, 5 figures, 2 tables.

  13. An FPGA-based trigger for the phase II of the MEG experiment

    Science.gov (United States)

    Baldini, A.; Bemporad, C.; Cei, F.; Galli, L.; Grassi, M.; Morsani, F.; Nicolò, D.; Ritt, S.; Venturini, M.

    2016-07-01

    For the phase II of MEG, we are going to develop a combined trigger and DAQ system. Here we focus on the former side, which operates an on-line reconstruction of detector signals and event selection within 450 μs from event occurrence. Trigger concentrator boards (TCB) are under development to gather data from different crates, each connected to a set of detector channels, to accomplish higher-level algorithms to issue a trigger in the case of a candidate signal event. We describe the major features of the new system, in comparison with phase I, as well as its performances in terms of selection efficiency and background rejection.

  14. Hydrogenation catalysts based on complexes of palladium(II) and polyvinylpyridines

    Energy Technology Data Exchange (ETDEWEB)

    Zharmagambetova, A.K.; Mukhamedzhanova, S.G.; Bekturov, E.A.; Saltykov, Yu.P.

    1992-05-20

    Recently methods for producing a new type of catalyst, grafted complexes have been developed. Polymers containing functional groups have been used quite successfully as a substrate in such catalysts. The refinement of the preparative method for metallopolymeric complexes (MPC) is of some importance. By varying the conditions of interaction between the polymers and the metal compounds the catalytic properties of MPC can be improved significantly. In this study the authors have looked at the effect of the preparative conditions for complexes of palladium(II) with poly-2-vinylpyridine (Pd-P2VP) on their catalytic activity in the hydrogenation of 2-propen-1-ol. 13 refs., 3 figs., 1 tab.

  15. Synthesis of an Enantipure Tetrazole-Based Homochiral Cu(I,II)-MOF for Enantioselective Separation.

    Science.gov (United States)

    Liu, Juan; Wang, Fei; Ding, Qing-Rong; Zhang, Jian

    2016-12-19

    An enantipure (1S)-1-(5-tetrazolyl)ethylamine (5-eatz) ligand was first employed to construct a homochiral porous metal-organic framework, {[Cu(I)2Cu(II)(5-eatz)2(CN(-))(H2O)](+)[NO3(-)]}·[DMF] (1), with unusual ligand-unsupported Cu···Cu interactions. Such a compound shows high stability in water and common organic solvents. Remarkably, it has high enantioselectivity toward (R,S)-1-phenylethanol and (R,S)-1-phenylpropanol with enantiomeric excess values of up to 42% and 48%, respectively.

  16. Synthesis and Crystal Structure of Binuclear and Pentanuclear Nickel(II Complexes Containing 4-(salicylaldiminatoantipyrine Schiff base

    Directory of Open Access Journals (Sweden)

    Mohamed N. EL-Kaheli

    2015-11-01

    Full Text Available The new title binuclear Ni (II compound  (1 and the novel pentanuclear Ni (II cluster {[   } (2 are formed from the reaction of an asymmetric Schiff base ligand L (L = 4-(salicylaldiminatoantipyrine with Ni .4  in the former or Ni(ClO42.6H2O in presence of malonate in the later.  Complex (1 consists of ( ]+ cation and one uncoordinated tetraphenylborate anion.  The cation adopts a distorted octahedral arrangement around each metal center.  In the binuclear unit both Ni(II ions are linked through two phenolate (µ2-O oxygen atoms of L, and two oxygen atoms of a  bridging carboxylate group. Each Ni (II coordinates to four oxygen atoms at the basal plane, two oxygen atoms from two bridging phenolate groups, one from pyrazolone ring and the last of an aqua molecule, and at the axial positions to a bridging carboxylate-O atom and an azomethine nitrogen atom.  In the pentanuclear cluster (2 consisting of [ ]+2 cation and two tetraphenylborate anions, the core of the cation is assembled by four [Ni( ] units, linked to the central Ni-ion by two bridging water molecules. The resulting coordination sphere for the external symmetry related nickel ions is a pseudo octahedron.  The central Ni-atom unusually adopts dodecahedron geometry through its coordination to eight bridging water molecules. In complex (1 each Ni-atom is coordinated to one tridentate L ligand and in complex (2 each [Ni ( ] unit is coordinated to two bidentate L ligands.  Inter-and intramolecular hydrogen bonds are present in both crystal structures.

  17. Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells.

    Science.gov (United States)

    Duff, Brian; Thangella, Venkat Reddy; Creaven, Bernadette S; Walsh, Maureen; Egan, Denise A

    2012-08-15

    This study determined the cytotoxic, cyto-selective and mutagenic potential of novel quinolinone Schiff base ligands and their corresponding copper(II) complexes in human-derived hepatic carcinoma cells (Hep-G2) and non-malignant human-derived hepatic cells (Chang). Results indicated that complexation of quinolinone Schiff bases with copper served to significantly enhance cytotoxicity. Here, the complex of (7E)-7-(3-ethoxy-2-hydroxybenzylideamino)-4-methylquinolin-2(1H)-one (TV117-FM) exhibited the lowest IC(50) value (17.9 μM) following 96 h continuous exposure, which was comparable to cisplatin (15.0 μM). However, results revealed that TV117-FM lacked cytoselectivity over non-malignant cells. Additionally, the complex was minimally effluxed from cells via Pglycoprotein (P-gp) and was shown to be non-mutagenic in the Standard Ames test. Furthermore, BrdU incorporation assays showed that it was capable of inhibiting DNA synthesis in a concentrationand time-dependent manner. However, inhibition was not as a consequence of DNA intercalation, as illustrated in electrophoretic mobility shift assays. Interestingly, it was shown that the ligand was capable of inhibiting the action of topoisomerase II, but this was lost following complexation. This indicated that the mechanism of action of the novel copper(II) complex was different from that of the parent ligand and suggests that TV117-FM may have a therapeutic role to play in the treatment of hepatocellular carcinoma. Studies are currently underway to elucidate the exact in vitro mechanism of action of this novel, metal-based anti-cancer agent.

  18. Ontology-based configuration of problem-solving methods and generation of knowledge-acquisition tools: application of PROTEGE-II to protocol-based decision support.

    Science.gov (United States)

    Tu, S W; Eriksson, H; Gennari, J H; Shahar, Y; Musen, M A

    1995-06-01

    PROTEGE-II is a suite of tools and a methodology for building knowledge-based systems and domain-specific knowledge-acquisition tools. In this paper, we show how PROTEGE-II can be applied to the task of providing protocol-based decision support in the domain of treating HIV-infected patients. To apply PROTEGE-II, (1) we construct a decomposable problem-solving method called episodic skeletal-plan refinement, (2) we build an application ontology that consists of the terms and relations in the domain, and of method-specific distinctions not already captured in the domain terms, and (3) we specify mapping relations that link terms from the application ontology to the domain-independent terms used in the problem-solving method. From the application ontology, we automatically generate a domain-specific knowledge-acquisition tool that is custom-tailored for the application. The knowledge-acquisition tool is used for the creation and maintenance of domain knowledge used by the problem-solving method. The general goal of the PROTEGE-II approach is to produce systems and components that are reusable and easily maintained. This is the rationale for constructing ontologies and problem-solving methods that can be composed from a set of smaller-grained methods and mechanisms. This is also why we tightly couple the knowledge-acquisition tools to the application ontology that specifies the domain terms used in the problem-solving systems. Although our evaluation is still preliminary, for the application task of providing protocol-based decision support, we show that these goals of reusability and easy maintenance can be achieved. We discuss design decisions and the tradeoffs that have to be made in the development of the system.

  19. Assembly of three novel metal (II) complexes based on polycarboxylate and 1,10-phenanthroline ligands

    Science.gov (United States)

    Chen, Xiaoli; Qiao, Yali; Gao, Loujun; Cui, Huali; Zhang, Meili; Lv, Junfang

    2013-04-01

    With the principles of crystal engineering, three novel metal(II) complexes, [Cu2(betd)(phen)4].15H2O (1), [Cd4(betd)2(phen)8]ṡ28H2O (2) and {[Co2(betd)(phen)2(H2O)2]·2H2O}n (3) (H4betd = bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid, phen = 1,10-phenanthroline) were synthesized and structurally characterized by elemental analyses, IR spectroscopy, single-crystal X-ray diffraction analyses, TGA, powder XRD and fluorescent measurements. Complex 1 is a binuclear structure, novel water tapes are observed to be encapsulated in the 3D open supramolecular architecture by hydrogen bond interactions. In 2, two pairs of CdII ions joined with two (betd)4- ions to form a cyclic tetranuclear structure. The neighboring tetranuclear units are linked into 2D network through π⋯π stacking interactions. Interestingly, the lattice H2O molecules are joined by strong hydrogen bond interactions generating a wavy water layer, which contacts the 2D network to form 3D supramolecular structure. 3 shows a 2D (4, 4) grid network, which are assembled in an ABAB sequence to 3D supramolecular structures via π⋯π stacking interactions between two central phen ligands from two adjacent sheets and hydrogen bond interactions.

  20. Event-driven timing system based on MRF cPCI hardware for HLS-II

    Institute of Scientific and Technical Information of China (English)

    李川; 王季刚; 宣科; 刘功发; 王琳; 李为民; 李京袆

    2015-01-01

    Hefei Light Source (HLS)-II is a vacuum ultraviole (VUV) synchrotron light source. A major upgrade of the light source was finished at the end of 2014. The timing system was rebuilt using compact peripheral component interconnect (cPCI) event-driven hardware to meet synchronization requirements of the machine. In the new system, the cPCI event-driven products manufactured by the micro-research finland (MRF) Oy are employed to achieve about 100 output signals with different interfaces. Device supports and drivers developed for common Experimental Physics and Industrial Control System (EPICS) records are used to access the registers on the timing modules. Five cPCI-bus input/output controllers (IOCs) distributed in different areas of the light source host timing modules for various subsystems. The delay resolution of this system is 9.8 ns for most channels and 9 ps for the channels used for triggering the electron gun and the injection kickers. The measured rms jitter of the output signal is less than 27 ps. Using the bucket chooser, this system enables the HLS-II to fill the storage ring with any designated bunch pattern. Benefitting from this upgrade, brightness and performance of the light source are significantly improved.

  1. A tetranuclear cadmium(II) complex based on the 2-(quinolin-8-yloxy)acetonitrile ligand.

    Science.gov (United States)

    Liu, Ming-Liang; Ye, Qiong

    2013-01-01

    The hydrothermal reaction of 2-(quinolin-8-yloxy)acetonitrile and Cd(ClO(4))(2) yielded the noncentrosymmetric coordination complex tetrakis[μ-2-(quinolin-8-yloxy)acetato]tetrakis[μ-2-(quinolin-8-yloxy)acetonitrile]tetracadmium tetrakis(perchlorate) dihydrate, [Cd(4)(C(11)H(8)NO(3))(4)(C(11)H(8)N(2)O)(4)](ClO(4))(4)·2H(2)O. The local coordination environment around the Cd(II) cation can be best described as a capped octahedron defined by two N atoms and five O atoms from three ligands. The Cd(II) cations are linked by the ligands with Cd-O-Cd and Cd-O-C-C-O-Cd bridges, forming tetranuclear units, there being two independent tertranuclear units in the structure. The fourfold rotoinversion centre sits at the centre of each Cd(4) core. The two perchlorate anions in the asymmetric unit are linked by the water molecule through O-H...O hydrogen bonds.

  2. Synthesis and characterization of tin(II) complexes of fluorinated Schiff bases derived from amino acids.

    Science.gov (United States)

    Singh, Har Lal

    2010-07-01

    New tin(II) complexes of general formula Sn(L)(2) (L=monoanion of 3-methyl-4-fluoro-acetophenone phenylalanine L(1)H, 3-methyl-4-fluoro-acetophenone alanine L(2)H, 3-methyl-4-fluoro acetophenone tryptophan L(3)H, 3-methyl-4-fluoro-acetophenone valine L(4)H, 3-methyl-4-fluoro-acetophenone isoleucine L(5)H and 3-methyl-4-fluoro-acetophenone glycine L(6)H) have been prepared. It is characterized by elemental analyses, molar conductance measurements and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance ((1)H, (13)C, (19)F and (119)Sn NMR) spectral studies. The ligands act as bidentate towards metal ions, via the azomethine nitrogen and deprotonated oxygen of the respective amino acid. Elemental analyses and NMR spectral data of the ligands with their tin(II) complexes agree with their proposed square pyramidal structures. A few representative ligands and their tin complexes have been screened for their antibacterial activities and found to be quite active in this respect. Copyright 2010 Elsevier B.V. All rights reserved.

  3. MEG II drift chamber characterization with the silicon based cosmic ray tracker at INFN Pisa

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M., E-mail: marco.venturini@pi.infn.it [INFN Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa (Italy); Baldini, A.M. [INFN Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Baracchini, E. [ICEPP, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Cei, F.; D' Onofrio, A. [INFN Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Dipartimento di Fisica, dell' Università di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Dussoni, S.; Galli, L.; Grassi, M. [INFN Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Nicolò, D. [INFN Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Dipartimento di Fisica, dell' Università di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Signorelli, G. [INFN Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy)

    2016-07-11

    High energy physics experiments at the high intensity frontier place ever greater demands on detectors, and in particular on tracking devices. In order to compare the performance of small size tracking prototypes, a high resolution cosmic ray tracker has been assembled to provide an external track reference. It consists of four spare ladders of the external layers of the Silicon Vertex Tracker of the BaBar experiment. The test facility, operating at INFN Sezione di Pisa, provides the detector under test with an external track with an intrinsic resolution of 15–30 μm. The MEG II tracker is conceived as a unique volume wire drift chamber filled with He–isobutane 85–15%. The ionization density in this gas mixture is about 13 clusters/cm and this results in a non-negligible bias of the impact parameters for tracks crossing the cell close to the anode wire. We present the telescope performance in terms of tracking efficiency and resolution and the results of the characterization of a MEG II drift chamber prototype.

  4. MEG II drift chamber characterization with the silicon based cosmic ray tracker at INFN Pisa

    Science.gov (United States)

    Venturini, M.; Baldini, A. M.; Baracchini, E.; Cei, F.; D`Onofrio, A.; Dussoni, S.; Galli, L.; Grassi, M.; Nicolò, D.; Signorelli, G.

    2016-07-01

    High energy physics experiments at the high intensity frontier place ever greater demands on detectors, and in particular on tracking devices. In order to compare the performance of small size tracking prototypes, a high resolution cosmic ray tracker has been assembled to provide an external track reference. It consists of four spare ladders of the external layers of the Silicon Vertex Tracker of the BaBar experiment. The test facility, operating at INFN Sezione di Pisa, provides the detector under test with an external track with an intrinsic resolution of 15-30 μm. The MEG II tracker is conceived as a unique volume wire drift chamber filled with He-isobutane 85-15%. The ionization density in this gas mixture is about 13 clusters/cm and this results in a non-negligible bias of the impact parameters for tracks crossing the cell close to the anode wire. We present the telescope performance in terms of tracking efficiency and resolution and the results of the characterization of a MEG II drift chamber prototype.

  5. Tuning COCOMO-II for Software Process Improvement: A Tool Based Approach

    Directory of Open Access Journals (Sweden)

    SYEDA UMEMA HANI

    2016-10-01

    Full Text Available In order to compete in the international software development market the software organizations have to adopt internationally accepted software practices i.e. standard like ISO (International Standard Organization or CMMI (Capability Maturity Model Integration in spite of having scarce resources and tools. The aim of this study is to develop a tool which could be used to present an actual picture of Software Process Improvement benefits in front of the software development companies. However, there are few tools available to assist in making predictions, they are too expensive and could not cover dataset that reflect the cultural behavior of organizations for software development in developing countries. In extension to our previously done research reported elsewhere for Pakistani software development organizations which has quantified benefits of SDPI (Software Development Process Improvement, this research has used sixty-two datasets from three different software development organizations against the set of metrics used in COCOMO-II (Constructive Cost Model 2000. It derived a verifiable equation for calculating ISF (Ideal Scale Factor and tuned the COCOMO-II model to bring prediction capability for SDPI (benefit measurement classes such as ESCP (Effort, Schedule, Cost, and Productivity. This research has contributed towards software industry by giving a reliable and low-cost mechanism for generating prediction models with high prediction accuracy. Hopefully, this study will help software organizations to use this tool not only to predict ESCP but also to predict an exact impact of SDPI.

  6. Photolithographically patterned enzyme membranes for the detection of pesticides and copper(II) based on enzyme inhibition

    Energy Technology Data Exchange (ETDEWEB)

    Zuern, A. (Inst. fuer Analytik und Umweltchemie, Univ. Halle, FB Chemie, Merseburg (Germany)); Mueller, H. (Inst. fuer Analytik und Umweltchemie, Univ. Halle, FB Chemie, Merseburg (Germany))

    A non-aqueous and an aqueous photopolymer system with an enzyme are used to prepare photolithographically patterned enzyme membranes for amperometric (thinfilm platinum electrode) and potentiometric (ISFET) sensors based on enzyme inhibition. Flow methods for enzyme inhibition tests are described. The decrease in enzyme (AChE) activity after incubation in a solution of dichlorvos as inhibitor is detected amperometrically. The enzyme urease is immobilized onto the pH-sensitive gate area of an ISFET. Such a biosensor is able to detect copper(II) in water in the ppm-range without preconcentration. (orig.)

  7. Ground-based research of crystal growth of II-VI compound semiconductors by physical vapor transport

    Science.gov (United States)

    Volz, M. P.; Gillies, D. C.; Szofran, F. R.; Lehoczky, S. L.; Su, Ching-Hua; Sha, Yi-Gao; Zhou, W.; Dudley, M.; Liu, Hao-Chieh; Brebrick, R. F.; Wang, J. C.

    1994-01-01

    Ground-based investigation of the crystal growth of II-VI semiconductor compounds, including CdTe, CdS, ZnTe, and ZnSe, by physical vapor transport in closed ampoules was performed. The crystal growth experimental process and supporting activities--preparation and heat treatment of starting materials, vapor partial pressure measurements, and transport rate measurements are reported. The results of crystal characterization, including microscopy, microstructure, optical transmission photoluminescence, synchrotron radiation topography, and chemical analysis by spark source mass spectrography, are also discussed.

  8. Synthesis and Characterization of New Schiff Bases Derived from N (1-Substituted Isatin with Dithiooxamide and Their Co(II, Ni(II, Cu(II, Pd(II, and Pt(IV Complexes

    Directory of Open Access Journals (Sweden)

    Ahlam J. Abdul-Ghani

    2009-01-01

    Full Text Available Three new Schiff bases of N-substituted isatin LI, LII, and LIII = Schiff base of N-acetylisatin, N-benzylisatin, and N-benzoylisatin, respectively, and their metal complexes C1a,b=[Co2(LI2Cl3]Cl, C2=[Ni(LI2Cl2]0.4BuOH, C3=[CuLICl(H2O]Cl⋅0.5BuOH, C4=[Pd(LI2Cl]Cl, C5=[Pt(L12Cl2]Cl2⋅1.8EtOH.H2O, C6a=[CoLIICl]Cl⋅0.4H2O⋅0.3DMSO, C6b=[CoLIICl]Cl⋅0.3H2O⋅0.1BuOH,C7=[NiLIICl2], C8=[CuLII]Cl2⋅H2O00000, C9=[Pd(LII2]Cl2, C10=[Pt(LII2.5Cl]Cl3, C11a=[Co(LIII]C12⋅H2O, C11b=[Co(LIII]Cl2⋅0.2H2O, and C12=[Ni(LIII2]Cl2, C13=[Ni(LIII2]Cl2 were reported. The complexes were characterized by elemental analyses, metal and chloride content, spectroscopic methods, magnetic moments, conductivity measurements, and thermal studies. Some of these compounds were tested as antibacterial and antifungal agents against Staphylococcus aureus, Proteus vulgaris, Candida albicans, and Aspergillus niger.

  9. Di- and tetra-nuclear copper(II), nickel(II), and cobalt(II) complexes of four bis-tetradentate triazole-based ligands: synthesis, structure, and magnetic properties.

    Science.gov (United States)

    Olguín, Juan; Kalisz, Marguerite; Clérac, Rodolphe; Brooker, Sally

    2012-05-07

    Four bis-tetradentate N(4)-substituted-3,5-{bis[bis-N-(2-pyridinemethyl)]aminomethyl}-4H-1,2,4-triazole ligands, L(Tz1)-L(Tz4), differing only in the triazole N(4) substituent R (where R is amino, pyrrolyl, phenyl, or 4-tertbutylphenyl, respectively) have been synthesized, characterized, and reacted with M(II)(BF(4))(2)·6H(2)O (M(II) = Cu, Ni or Co) and Co(SCN)(2). Experiments using all 16 possible combinations of metal salt and L(TzR) were carried out: 14 pure complexes were obtained, 11 of which are dinuclear, while the other three are tetranuclear. The dinuclear complexes include two copper(II) complexes, [Cu(II)(2)(L(Tz2))(H(2)O)(4)](BF(4))(4) (2), [Cu(II)(2)(L(Tz4))(BF(4))(2)](BF(4))(2) (4); two nickel(II) complexes, [Ni(II)(2)(L(Tz1))(H(2)O)(3)(CH(3)CN)](BF(4))(4)·0.5(CH(3)CN) (5) and [Ni(II)(2)(L(Tz4))(H(2)O)(4)](BF(4))(4)·H(2)O (8); and seven cobalt(II) complexes, [Co(II)(2)(L(Tz1))(μ-BF(4))](BF(4))(3)·H(2)O (9), [Co(II)(2)(L(Tz2))(μ-BF(4))](BF(4))(3)·2H(2)O (10), [Co(II)(2)(L(Tz3))(H(2)O)(2)](BF(4))(4) (11), [Co(II)(2)(L(Tz4))(μ-BF(4))](BF(4))(3)·3H(2)O (12), [Co(II)(2)(L(Tz1))(SCN)(4)]·3H(2)O (13), [Co(II)(2)(L(Tz2))(SCN)(4)]·2H(2)O (14), and [Co(II)(2)(L(Tz3))(SCN)(4)]·H(2)O (15). The tetranuclear complexes are [Cu(II)(4)(L(Tz1))(2)(H(2)O)(2)(BF(4))(2)](BF(4))(6) (1), [Cu(II)(4)(L(Tz3))(2)(H(2)O)(2)(μ-F)(2)](BF(4))(6)·0.5H(2)O (3), and [Ni(II)(4)(L(Tz3))(2)(H(2)O)(4)(μ-F(2))](BF(4))(6)·6.5H(2)O (7). Single crystal X-ray structure determinations revealed different solvent content from that found by microanalysis of the bulk sample after drying under a vacuum and confirmed that 5', 8', 9', 11', 12', and 15' are dinuclear while 1' and 7' are tetranuclear. As expected, magnetic measurements showed that weak antiferromagnetic intracomplex interactions are present in 1, 2, 4, 7, and 8, stabilizing a singlet spin ground state. All seven of the dinuclear cobalt(II) complexes, 9-15, have similar magnetic behavior and remain in the [HS-HS] state

  10. Syntheses, Structures, and Characterization of Two Novel Copper(II) and Cadmium(II) Compounds Based on Pyridyl Conjugated 1,2,3-Triazole

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jinlong; Wang, Gaigai; Zhao, Hong [Southeast Univ., Nanjing (Korea, Republic of); Qu, Zhirong; Ma Huajun [Hangzhou Normal Univ., Hangzhou (China)

    2014-05-15

    Two new complexes with 5-methyl-1-(pyridine-3-yl)-1H-1,2,3-triazole-4-carboxylic acid ligand: [Cd(mptc){sub 2}(H{sub 2}O){sub 4}] and [Cu(mptc){sub 4}·2H{sub 2}O]{sub n} were prepared and their crystal structures were determined by single crystal X-ray diffraction analyses. In complex, the Cd(II) ions coordinates with the pyridyl nitrogen atom from the ligand, forming a mononuclear Cd(II) compound. Complex exhibits a novel two-dimensional (2D) polymer in which four ligands stabilize the Cu(II) atom. And the coordination involves one nitrogen atom of the triazole, one oxygen atom of the carboxylic acid and the pyridyl nitrogen atom. In addition, FT-IR and solid-state fluorescent emission spectroscopy of two compounds have been determined.

  11. The use of a polymer inclusion membrane in a paper-based sensor for the selective determination of Cu(II).

    Science.gov (United States)

    Jayawardane, B Manori; Coo, Lilibeth dlC; Cattrall, Robert W; Kolev, Spas D

    2013-11-25

    A disposable paper-based sensor (PBS) is described for the determination of Cu(II) in natural and waste waters at approximately 2 cents per measurement. The device makes use of a polymer inclusion membrane (PIM) to provide the selectivity for Cu(II). The PIM consists of 40 wt% di(2-ethlyhexyl) phosphoric acid (D2EHPA) as the carrier, 10 wt% dioctyl phthalate (DOP) as a plasticizer, 49.5 wt% poly(vinyl chloride) (PVC) as the base polymer and 0.5 wt% (mm(-1)) 1-(2'-pyridylazo)-2-naphthol (PAN) as the colourimetric reagent. High selectivity under mildly acidic conditions (HCl, pH 2.0) is achieved for Cu(II) in the presence of frequently encountered metal ions in natural and waste waters such as Fe(III), Al(III), Zn(II), Cd(II), Pb(II), Ca(II), Mg(II), and Ni(II). The laminated PBS consists of a PIM sensing disc (2mm in diameter) attached to the centre of a circular hydrophilic zone (7 mm in diameter) pretreated with 0.01 M HCl. This hydrophilic zone separates the sample port (a circular hole in the plastic cover) from the PIM sensing disc. After introducing 19.2 μL of a sample/standard solution to the sample port, Cu(II) diffuses across the hydrophilic zone and is extracted into the PIM disc as the Cu(II)-D2EHPA complex which subsequently reacts with PAN to produce the red-purple coloured Cu(II)-PAN complex. The colour intensity of the PIM disc is measured 15 min after sample/standard introduction by scanning using a flatbed scanner. Under optimal conditions the device is characterized by a limit of detection (LOD) and limit of quantitation (LOQ) of 0.06 and 0.21 mg L(-1) Cu(II), respectively, with two linear ranges together covering the Cu(II) concentration range from 0.1 to 30.0 mg L(-1). The PBS was successfully applied to the determination of Cu(II) in hot tap water and mine tailings water.

  12. Determination of metallothioneins by fluorescence and resonance light scattering strategies based on ciprofloxacin–Cu(II) system

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Lu [College of Public Health, University of South China, Hengyang 421001 (China); Wang, Yong-Sheng, E-mail: yongsheng.w@tom.com [College of Public Health, University of South China, Hengyang 421001 (China); Xue, Jin-Hua; Yang, Hui-Xian; Li, Qiu; Zhou, Bin; Wang, Jia-Cheng; Yin, Ji-Cheng; Wang, Yong-Song [College of Public Health, University of South China, Hengyang 421001 (China); Xiao, Xi-Lin [College of Chemistry and Chemical Engineering, University of South China, Hengyang 421001 (China)

    2013-06-15

    Based on ciprofloxacin (CIP)–Cu(II) system, the novel methods for the detection of metallothioneins (MTs) have been developed by fluorescence (FL) and resonance light scattering (RLS) strategies. The FL strategy avoids the label and derivatization steps in common methods, while the RLS strategy can be applied for determining bio-macromolecules and small molecules without native fluorescence. The response signals linearly correlated with the concentration of MTs over the ranges of 1.03×10{sup −8}–1.23×10{sup −6} mol L{sup −1} for FL, and of 2.56×10{sup −7}–1.54×10{sup −6} mol L{sup −1} for RLS. The limits of detection (LOD) are 3.1×10{sup −9} mol L{sup −1} for FL and 7.68×10{sup −8} mol L{sup −1} for RLS. This study represents the comparison of these two methods using the same CIP–Cu{sup 2+}–MTs system. They not only allow practical application for MTs detection but also serve as a potential choice for the operators according to their concrete needs. In addition, the mechanisms for FL and RLS enhancement of the system were also discussed. -- Highlights: ► Determination of MTs was developed based on CIP–Cu(II) system by FL and RLS strategies. ► FL strategy provides lower limit of detection and wider linear range, and avoids the label and derivatization steps. ► RLS strategy can be applied for determining bio-macromolecules and small molecules. ► The mechanism of interaction of MTs with CIP–Cu(II) chelate was discussed.

  13. Coordination polymer based on Cu(II), Co(II) and 4,4'-bipyridine-2,6,2',6'-tetracarboxylate: synthesis, structure and adsorption properties.

    Science.gov (United States)

    Zhao, Zhou; He, Xiang; Zhao, Yongmei; Shao, Min; Zhu, Shourong

    2009-04-21

    4,4'-Bipyridine-2,6,2',6'-tetracarboxylic acid H4L.3H2O, () and its copper(II) and cobalt (II) coordination polymers [Cu2L(H2O)4]2n () and {[Co(H2O)6].[Co3L2(H2O)2].10H2O}3n () have been hydrothermally synthesized. Compound packs into a crystal via H-bonds. Complex is a 2D coordination grid, in which Cu is in an elongated octahedral constructed by a mer-geometry pyridyl-2,6-dicarboxylate, one bridging carboxylate oxygen and two water molecules. The L4- is central symmetrical. Each pyridyl-2,6-dicarboxylate chelete to Cu(II) and one carboxylate bridge Cu(II) ions in a 1,1-fashion. The 2D coordination polymer links to adjacent layers via H-bonds. Complex is a metal-organic framework with 11.6x10.5 A rectangular channels. All Co(II) ions are located in an octahedral coordination environment. The rectangular channels are composed of Co2+-L4- walls and the walls are linked through carboxylate oxygen atoms and Co(II) ions. Co(H2O)6(2+) as counter ions fill in porous channel. The removal of water molecules from at 210 degrees C or higher affords the porous material [Co4L2]n, which can adsorb 16 (36%) methanol or 9 (32%) ethanol in the vapour phase. The porosity of is higher than reported 4,4'-bipyridine-2,6,2',6'- tetracarboxylate complexes. The framework of remains but the crystallinity is lost upon removal of the H2O molecules. The dehydrated framework of partially recovery crystallinity after it adsorbs H2O, CH3OH and C2H5OH. The methanol in the framework can be replaced by H2O reversibly.

  14. A highly pixelated CdZnTe detector based on \\textit{Topmetal-${II}^-$} sensor

    CERN Document Server

    Zou, Shuguang; Sun, Xiangming; Huang, Guangming; Pei, Hua; Wang, Zhen; Liu, Jun; Yang, Ping; Wang, Dong

    2016-01-01

    \\textit{Topmetal-${II}^-$} is a low noise CMOS pixel direct charge sensor with a pitch of 83$\\mu m$. CdZnTe is an excellent semiconductor material for radiation detection. The combination of CdZnTe and the sensor makes it possible to build a detector with high spatial resolution. In our experiments, an epoxy adhesive is used as the conductive medium to connect the sensor and CdZnTe. The diffusion coefficient and charge efficiency of electrons are measured at a low bias voltage of -2 Volts, and the image of a single alpha is clear with a reasonable spatial resolution. The detector of such structure has the potential to be applied in X-ray imaging systems with a further improvements of the sensor.

  15. Organic-Ruthenium(II Polypyridyl Complex Based Sensitizer for Dye-Sensitized Solar Cell Applications

    Directory of Open Access Journals (Sweden)

    Lingamallu Giribabu

    2011-01-01

    Full Text Available A new high molar extinction coefficient organic-ruthenium(II polypyridyl complex sensitizer (RD-Cou that contains 2,2,6,6-tetramethyl-9-thiophene-2-yl-2,3,5,6,6a,11c-hexahydro1H,4H-11oxa-3a-aza-benzoanthracene-10-one as extended -conjugation of ancillary bipyridine ligand, 4,4-dicaboxy-2,26,2-bipyridine, and a thiocyanate ligand in its molecular structure has been synthesized and completely characterized by CHN, Mass, 1H-NMR, UV-Vis, and fluorescence spectroscopies as well as cyclic voltammetry. The new sensitizer was tested in dye-sensitized solar cells using a durable redox electrolyte and compared its performance to that of standard sensitizer Z-907.

  16. Stratospheric ozone depletion over Antarctica - Role of aerosols based on SAGE II satellite observations

    Science.gov (United States)

    Lin, N.-H.; Saxena, V. K.

    1992-01-01

    The physical characteristics of the Antarctic stratospheric aerosol are investigated via a comprehensive analysis of the SAGE II data during the most severe ozone depletion episode of October 1987. The aerosol size distribution is found to be bimodal in several instances using the randomized minimization search technique, which suggests that the distribution of a single mode may be used to fit the data in the retrieved size range only at the expense of resolution for the larger particles. On average, in the region below 18 km, a wavelike perturbation with the upstream tilting for the parameters of mass loading, total number, and surface area concentration is found to be located just above the region of the most severe ozone depletion.

  17. Optimizing Transmission Service Cost of Khuzestan Regional Grid Based on Nsga-Ii Algorithm

    Science.gov (United States)

    Shooshtari, Alireza Tavakoli; Joorabian, Mahmood; Milani, Armin Ebrahimi; Gholamzadeh, Arash

    2011-06-01

    Any plan for modeling the components of transmission service costs should be able to consider congestion as well as loss cost. Assessing the real value of congestion and loss costs in each network has a substantial contribution to analyze the grid's weaknesses in order to release capacity of power network. As much as the amount of congestion and loss costs in the transmission grid reduces the amount of power passing through transmission lines increases. Therefore, the transmission service cost will be optimized and revenues of the regional electricity company from transmission services will be increased. In this paper, a new power flow algorithm with congestion and loss considerations of a power network is presented. Thus, optimal power flow and a multi-objectives optimization algorithm, called NSGA-II, is used in this work. The real data of Khuzestan regional power grid is implemented to confirm the efficiency of proposed method.

  18. Development of a TaqMan Probe-Based Insulated Isothermal Polymerase Chain Reaction (iiPCR) Assay for Detection of Fusarium oxysporum f. sp. cubense Race 4

    Science.gov (United States)

    Lin, Yi-Jia; Chang, Tsai-De; Hong, Li-Ling; Chen, Tzu-Yu; Chang, Pi-Fang Linda

    2016-01-01

    This study developed a novel and inexpensive detection method based on a TaqMan probe-based insulated isothermal polymerase chain reaction (iiPCR) method for the rapid detection of Panama disease caused by Fusarium oxysporum f. sp. cubense (Foc) race 4, which is currently among the most serious fungal vascular diseases worldwide. By using the portable POCKIT™ device with the novel primer set iiFoc-1/iiFoc-2, the Foc race 4 iiPCR assay (including DNA amplification and signal monitoring) could be completed within one hour. The developed Foc race 4 iiPCR assay is thus a user-friendly and efficient platform designed specifically for the detection of Foc race 4. The detection limit of this optimized Foc iiPCR system was estimated to be 1 copy of the target standard DNA as well as 1 fg of the Foc genomic DNA. This approach can serve as a rapid detection method for in planta detection of Foc race 4 in field-infected banana. It was concluded that this molecular detection procedure based on iiPCR has good potential for use as an efficient detection method. PMID:27448242

  19. Development of a TaqMan Probe-Based Insulated Isothermal Polymerase Chain Reaction (iiPCR Assay for Detection of Fusarium oxysporum f. sp. cubense Race 4.

    Directory of Open Access Journals (Sweden)

    Ying-Hong Lin

    Full Text Available This study developed a novel and inexpensive detection method based on a TaqMan probe-based insulated isothermal polymerase chain reaction (iiPCR method for the rapid detection of Panama disease caused by Fusarium oxysporum f. sp. cubense (Foc race 4, which is currently among the most serious fungal vascular diseases worldwide. By using the portable POCKIT™ device with the novel primer set iiFoc-1/iiFoc-2, the Foc race 4 iiPCR assay (including DNA amplification and signal monitoring could be completed within one hour. The developed Foc race 4 iiPCR assay is thus a user-friendly and efficient platform designed specifically for the detection of Foc race 4. The detection limit of this optimized Foc iiPCR system was estimated to be 1 copy of the target standard DNA as well as 1 fg of the Foc genomic DNA. This approach can serve as a rapid detection method for in planta detection of Foc race 4 in field-infected banana. It was concluded that this molecular detection procedure based on iiPCR has good potential for use as an efficient detection method.

  20. Synthesis, characterization and thermal studies of binary and/or mixed ligand complexes of Cd(II), Cu(II), Ni(II) and Co(III) based on 2-(Hydroxybenzylidene) thiosemicarbazone: DNA binding affinity of binary Cu(II) complex.

    Science.gov (United States)

    Saif, M; Mashaly, Mahmoud M; Eid, Mohamed F; Fouad, R

    2012-06-15

    A new series of metal complexes of Cd(II), Cu(II), Ni(II) and Co(III) with Schiff base ligand, H(2)L, 2-(Hydroxybenzylidene) thiosemicarbazone were synthesized. The mixed ligand complexes were prepared by using glycine (Gly), 2-aminopyridine (2-Ampy) and 1,10-phenanthroline (Phen) as secondary ligands. The structure of these complexes was identified and confirmed by elemental analysis, molar conductivity, UV-Vis, FT-IR and (1)H NMR spectroscopy and magnetic moment measurements as well as TG-DSC technique. The discussions of the prepared complexes indicate that the ligand behaves as a monoanionic tridentate ligand through ONS donor sites. Thermal studies suggested a mechanism for the degradation of the metal complexes as a function of temperature supporting the chelation modes and showed the possibility of obtaining new complexes pyrolytically in the solid state which cannot be synthesized from the solution. The absorption studies support that the binary Cu(II) complex exhibits a significant binding affinity to HS-DNA through intercalative mode.

  1. Selection of Chelated Fe (III)/Fe (II) Catalytic Oxidation Agents for Desulfurization Based on Iron Complexation Method

    Institute of Scientific and Technical Information of China (English)

    Luo Ying; Liu Youzhi; Qi Guisheng; Guo Huidong; Zhu Zhengfeng

    2014-01-01

    Optimization of factors inlfuencing the experiments on reactions involving 8 different chelating agents and sol-uble Fe (III)/Fe (II) salts was carried out to yield chelated iron complexes. A combination of optimized inlfuencing factors has resulted in a Fe chelating capacity of the iron-based desulfurization solution to be equal to 6.83—13.56 g/L at a redox potential of 0.185—0.3. The desulfurization performance of Fe (III)/Fe (II) chelating agents was investigated on a simulated sulfur-containing industrial gas composed of H2S and N2 in a cross-lfow rotating packed bed. Test results have revealed that the proposed iron-based desulfurization solution showed a sulfur removal efifciency of over 99%along with a Fe chelating capacity exceeding 1.35 g/L. This desulfurization technology which has practical application prospect is currently in the phase of commercial scale-up study.

  2. Synthesis, crystal structures, spectroscopic characterization and in vitro antidiabetic studies of new Schiff base Copper(II) complexes

    Indian Academy of Sciences (India)

    SUNDARAMURTHY SANTHA LAKSHMI; KANNAPPAN GEETHA; M GAYATHRI; GANESH SHANMUGAM

    2016-07-01

    Two new Schiff base copper(II) complexes, [CuL¹(tmen)] (1) and [Cu₂L₂² (tmen)] (2) {where, H₂L¹ = N-(salicylidene)-L-valine, H₂L² = N-(3,5-dichlorosalicylidene)-L-valine and tmen = N,N,N',N'- tetramethylethylene-1,2-diamine} have been synthesized and characterized by molar conductance, elemental analyses, VSM-RT, UV-Vis, FTIR, EPR, and CD spectra. Both the complexes were structurally characterized by single crystal XRD. The crystal structure of complex 1 displays a distorted square pyramidal geometry in which Schiff base is coordinated to the Cu(II) ion via ONO-donor in the axial mode, whereas, the chelating diamine displays axial and equatorial mode of binding via NN-donor atoms. The crystal structure of the complex 2 reveals a syn-anti mode of carboxylate bridged dinuclear complex, in which, the coordination geometry around Cu(1) is square pyramid and distorted square planar around Cu(2). The target complexes were screened for in vitro antidiabetic activity. Both the complexes showed good inhibitory activity for α-amylase and α-glucosidase.

  3. Luminescent cyclometalated alkynylplatinum(II) complexes with a tridentate pyridine-based N-heterocyclic carbene ligand: synthesis, characterization, electrochemistry, photophysics, and computational studies.

    Science.gov (United States)

    Leung, Sammual Yu-Lut; Lam, Elizabeth Suk-Hang; Lam, Wai Han; Wong, Keith Man-Chung; Wong, Wing-Tak; Yam, Vivian Wing-Wah

    2013-07-29

    A new class of luminescent alkynylplatinum(II) complexes with a tridentate pyridine-based N-heterocyclic carbene (2,6-bis(1-butylimidazol-2-ylidenyl)pyridine) ligand, [Pt(II)(C^N^C)(C≡CR)][PF6], and their chloroplatinum(II) precursor complex, [Pt(II)(C^N^C)Cl][PF6], have been synthesized and characterized. One of the alkynylplatinum(II) complexes has also been structurally characterized by X-ray crystallography. The electrochemistry, electronic absorption and luminescence properties of the complexes have been studied. Nanosecond transient absorption (TA) spectroscopy has also been performed to probe the nature of the excited state. The origin of the absorption and emission properties has been supported by computational studies.

  4. Six-coordinate high-spin iron(ii) complexes with bidentate PN ligands based on 2-aminopyridine - new Fe(ii) spin crossover systems.

    Science.gov (United States)

    Holzhacker, Christian; Calhorda, Maria José; Gil, Adrià; Carvalho, Maria Deus; Ferreira, Liliana P; Stöger, Berthold; Mereiter, Kurt; Weil, Matthias; Müller, Danny; Weinberger, Peter; Pittenauer, Ernst; Allmaier, Günter; Kirchner, Karl

    2014-08-01

    Several new octahedral iron(ii) complexes of the type [Fe(PN(R)-Ph)2X2] (X = Cl, Br; R = H, Me) containing bidentate PN(R)-Ph (R = H, Me) (1a,b) ligands based on 2-aminopyridine were prepared. (57)Fe Mössbauer spectroscopy and magnetization studies confirmed in all cases their high spin nature at room temperature with magnetic moments very close to 4.9μB reflecting the expected four unpaired d-electrons in all these compounds. While in the case of the PN(H)-Ph ligand an S = 2 to S = 0 spin crossover was observed at low temperatures, complexes with the N-methylated analog PN(Me)-Ph retain an S = 2 spin state also at low temperatures. Thus, [Fe(PN(H)-Ph)2X2] (2a,3a) and [Fe(PN(Me)-Ph)2X2] (2b,3b) adopt different geometries. In the first case a cis-Cl,P,N-arrangement seems to be most likely, as supported by various experimental data derived from (57)Fe Mössbauer spectroscopy, SQUID magnetometry, UV/Vis, Raman, and ESI-MS as well as DFT and TDDFT calculations, while in the case of the PN(Me)-Ph ligand a trans-Cl,P,N-configuration is adopted. The latter is also confirmed by X-ray crystallography. In contrast to [Fe(PN(Me)-Ph)2X2] (2b,3b), [Fe(PN(H)-Ph)2X2] (2a,3a) is labile and undergoes rearrangement reactions. In CH3OH, the diamagnetic dicationic complex [Fe(PN(H)-Ph)3](2+) (5) is formed via the intermediacy of cis-P,N-[Fe(κ(2)-P,N-PN(H)-Ph)2(κ(1)-P-PN(H)-Ph)(X)](+) (4a,b) where one PN ligand is coordinated in a κ(1)-P-fashion. In CH3CN the diamagnetic dicationic complex cis-N,P,N-[Fe(PN(H)-Ph)2(CH3CN)2](2+) (6) is formed as a major isomer where the two halide ligands are replaced by CH3CN.

  5. Syntheses, structures and properties of Zn(II) and Cu(II) complexes based on N2-2-methylenepyridinyl 1,2,3-triazole ligand

    Science.gov (United States)

    Chen, Yunfeng; Wu, Jun; Ma, Shan; Zhou, Shilei; Meng, Xianggao; Jia, Lihui; Pan, Zhiquan

    2015-06-01

    Four new Zn(II) and Cu(II) coordinated polymers ([ZnL2N3]ClO4 (1), [Cu2L2(CH3CN)]Cl4 (2) [CuL](NO3)2 (3), [Cu(H2O)L](SO4) (4) L = 2-((4-phenyl-2H-1,2,3-triazol-2-yl)methyl) pyridine (ptmp)) have been reported. All the compounds have been characterized by IR spectrum, elemental analyses and X-ray crystallography diffraction. Single-crystal X-ray diffraction analyses show that one-dimensional polymers are formed in these four complexes. Chain-like structures are formed in complex 1, 2 and 3, which are connected by azide, chloride and nitrate anions, respectively. In complex 4, one-dimensional left-handed polymer is formed by a μ2-SO4 bridge. The fluorescent and electrochemical properties of these four complexes were investigated. It was found that these three Cu(II) complexes displayed a quenching of fluorescence, while Zn(II) complex exhibited a clear enhanced fluorescence.

  6. Mononuclear thiocyanate containing nickel(II) and binuclear azido bridged nickel(II) complexes of N4-coordinate pyrazole based ligand: Syntheses, structures and magnetic properties

    Science.gov (United States)

    Solanki, Ankita; Monfort, Montserrat; Kumar, Sujit Baran

    2013-10-01

    Two mononuclear nickel(II) complexes [NiL1(NCS)2] (1) and [NiL2(NCS)2] (2) and two azido bridged binuclear nickel(II) complexes [Ni(()2()2] (3) and [Ni(()2()2] (4), where L1, L2, L1‧ and L2‧ are N,N-diethyl-N‧,N‧-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)ethane-1,2-diamine (L1), N,N-bis((1H-pyrazol-1-yl)methyl)-N‧,N‧-diethylethane-1,2-diamine (L2), N,N-diethyl-N‧-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)ethane-1,2-diamine (L1‧) and N-((1H-pyrazol-1-yl)methyl)-N‧,N‧-diethylethane-1,2-diamine (L2‧) have been synthesized and characterized by microanalyses and physico-chemical methods. Single crystal X-ray diffraction analyses revealed that complexes 1 and 2 are mononuclear NCS- containing Ni(II) complex with octahedral geometry and complexes 3 and 4 are end-on (μ-1,1) azido bridged binuclear Ni(II) complexes with distorted octahedral geometry. Variable temperature magnetic studies of the complexes 3 and 4 display ferromagnetic interaction with J values 19 and 32 cm-1, respectively.

  7. Synthesis and Characterization of Phenothiazine-Based Platinum(II)-Acetylide Photosensitizers for Efficient Dye-Sensitized Solar Cells.

    Science.gov (United States)

    Siu, Chi-Ho; Lee, Lawrence Tien Lin; Yiu, Sze-Chun; Ho, Po-Yu; Zhou, Panwang; Ho, Cheuk-Lam; Chen, Tao; Liu, Jianyong; Han, Keli; Wong, Wai-Yeung

    2016-03-07

    Three new unsymmetrical phenothiazine-based platinum(II) bis(acetylide) complexes PT1-PT3 with different electron-donating arylacetylide ligands were synthesized and characterized. Their photophysical, electrochemical, and photovoltaic properties have been fully investigated and the density functional theory (DFT) calculations have been carried out. Under AM 1.5 irradiation (100 mW cm(-2)), the PT1-based dye-sensitized solar cell (DSSC) device exhibited an attractive power conversion efficiency (η) up to 5.78 %, with a short-circuit photocurrent density (J(sc)) of 10.98 mA cm(-2), an open-circuit photovoltage (V(oc)) of 0.738 V, and a fill factor (ff) of 0.713. These findings provide strong evidence that platinum-acetylide complexes have great potential as promising photosensitizers in DSSC applications.

  8. Synthesis, characterization, and biological activity of some novel Schiff bases and their Co(II) and Ni(II) complexes: A new route for Co3O4 and NiO nanoparticles for photocatalytic degradation of methylene blue dye

    Science.gov (United States)

    Nassar, Mostafa Y.; Aly, Hisham M.; Abdelrahman, Ehab A.; Moustafa, Moustafa E.

    2017-09-01

    Six novel Co(II) and Ni(II)-triazole Schiff base complexes have been successfully synthesized by refluxing the prepared triazole Schiff bases with CoCl2·6H2O or NiCl2·6H2O. The Schiff base ligands were prepared through condensation of 3-R-4-amino-5-hydrazino-1,2,4-triazole with dibenzoylmethane [Rdbnd H, CH3, and CH2CH3; namely, L1, L2, and L3, respectively]. The prepared Co(II) and Ni(II) complexes have been identified using elemental analysis, FT-IR, UV-Vis, magnetic moment, conductivity, and thermal analysis. On the basis of the conductance results, it was concluded that all the prepared complexes are nonelectrolytes. Interestingly, the prepared Co(II) and Ni(II) complexes were employed as precursors for producing of Co3O4 and NiO nanoparticles, respectively. The produced nanostructures have been identified by XRD, HR-TEM, FT-IR and UV-Vis spectra. The produced nanoparticles revealed good photocatalytic activity for the degradation of methylene blue dye under UV illumination in presence of hydrogen peroxide. The percent of degradation was estimated to be 55.71% in 420.0 min and 90.43% in 360.0 min for Co3O4 and NiO, respectively. Moreover, the synthesized complexes, nano-sized Co3O4, and NiO products have been examined, employing modified Bauer- Kirby method, for antifungal (Candida albicans and Aspergillus flavus) and antibacterial (Staphylococcus aureus and Escherichia coli) activities.

  9. Installation Restoration Program. Phase II, Stage 1. Problem Confirmation Study, Luke Air Force Base, Glendale, Arizona.

    Science.gov (United States)

    1984-11-01

    potable water in LAFB. Surface water from the Central Arizona Project (CAP) is available to the Base, but at a significantly higher cost than that of...available supplies of potable water which currently support the Base mission at LAFB. 1-16 1-16 SECTION 2 ENVIRONMENTAL SETTING 2.1 REGIONAL GEOLOGY Luke Air...the northern portion of the Base discharges toward the nearest natural surface water feature, the Agua Fria River. Figure 2-1 summarizes surface

  10. Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II Complexes

    Directory of Open Access Journals (Sweden)

    Ladislav Habala

    2016-12-01

    Full Text Available In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C. albicans. All copper(II complexes showed excellent inhibitory properties against jack bean urease, considerably better than that of the standard inhibitor acetohydroxamic acid.

  11. Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes.

    Science.gov (United States)

    Habala, Ladislav; Varényi, Samuel; Bilková, Andrea; Herich, Peter; Valentová, Jindra; Kožíšek, Jozef; Devínsky, Ferdinand

    2016-12-17

    In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C. albicans. All copper(II) complexes showed excellent inhibitory properties against jack bean urease, considerably better than that of the standard inhibitor acetohydroxamic acid.

  12. Disposable biosensor based on cathodic electrochemiluminescence of tris(2,2-bipyridine)ruthenium(II) for uric acid determination

    Energy Technology Data Exchange (ETDEWEB)

    Ballesta-Claver, J.; Rodríguez-Gómez, R. [ECsens, Department of Analytical Chemistry, Campus Fuentenueva, Faculty of Sciences, University of Granada, E-18071 Granada (Spain); Capitán-Vallvey, L.F., E-mail: lcapitan@ugr.es [ECsens, Department of Analytical Chemistry, Campus Fuentenueva, Faculty of Sciences, University of Granada, E-18071 Granada (Spain)

    2013-04-03

    Highlights: ► Cathodic ECL offers conventional and non-aggressive analysis conditions. ► The ECL hydrogen peroxide/ruthenium complex system for uric acid determination is novel. ► The ruthenium complex is electrochemically immobilized on graphite screen-printed electrodes. ► The quantification of the uric acid is based on a Stern–Volmer type equation. ► The use of the cathodic ECL working methodology reduces interferences during analysis. -- Abstract: A new method for uric acid (UA) determination based on the quenching of the cathodic ECL of the tris(2,2-bipyridine)ruthenium(II)–uricase system is described. The biosensor is based on a double-layer design containing first tris(2,2-bipyridine)ruthenium(II) (Ru(bpy){sub 3}{sup 2+}) electrochemically immobilized on graphite screen-printed cells and uricase in chitosan as a second layer. The uric acid biosensing is based on the ECL quenching produced by uric acid over the cathodic ECL caused by immobilized Ru(bpy){sub 3}{sup 2+} in the presence of uricase. The use of a −1.1 V pulse for 1 s with a dwelling time of 10 s makes it possible to estimate the initial enzymatic rate, which is used as the analytical signal. The Stern–Volmer type calibration function shows a dynamic range from 1.0 × 10{sup −5} to 1.0 × 10{sup −3} M with a limit of detection of 3.1 × 10{sup −6} M and an accuracy of 13.6% (1.0 × 10{sup −4} M, n = 5) as relative standard deviation. Satisfactory results were obtained for urine samples, creating an affordable alternative for uric acid determination.

  13. Synthesis, Characterization and Use of Schiff Bases as Fluorimetric Analytical Reagents (Part II)

    OpenAIRE

    Mohamed N. Ibrahim; Salaheddin A. I. Sharif

    2011-01-01

    Many Schiff bases were prepared by condensation reaction of certain aromatic amines with aromatic aldehydes derivatives and then the fluorescence properties of these Schiff bases were examined in acidic and basic media. It is shown that these compounds can be used for fluorimetric monitoring of small pH changes.

  14. Synthesis, Characterization and Use of Schiff Bases as Fluorimetric Analytical Reagents (Part II

    Directory of Open Access Journals (Sweden)

    Mohamed N. Ibrahim

    2011-01-01

    Full Text Available Many Schiff bases were prepared by condensation reaction of certain aromatic amines with aromatic aldehydes derivatives and then the fluorescence properties of these Schiff bases were examined in acidic and basic media. It is shown that these compounds can be used for fluorimetric monitoring of small pH changes.

  15. Base cation deposition in Europe - Part II. Acid neutralization capacity and contribution to forest nutrition

    NARCIS (Netherlands)

    Draaijers, G.P.J.; Leeuwen, E.P. van; Jong, P.G.H. de; Erisman, J.W.

    1997-01-01

    An assessment was made of the capacity of base cations to neutralize acid deposition and of the contribution of base cation deposition to forest nutrition in Europe. In large parts of southern Europe more than 50% of the potential acid deposition was found counteracted by deposition of non-sea salt

  16. Installation Restoration Program, Phase II - Confirmation/Quantification Stage I, Moody Air Force Base, Georgia.

    Science.gov (United States)

    1985-12-01

    ABBREVIATIONS, AND UNITS OF MESUREMENT ~~(Page I of 2) "’ 2 % W. -* AFB Air Force Base ATC Air Training Command I ASTM American Society for Testing Materials...following emergency phone numbers should be available * 1 on-site: I. Ambulance or medical assistance, 2. Base fire department (or other if off-site), and

  17. Hanna, Wyoming underground coal gasification data base. Volume 3. The Hanna II, Phase I field test

    Energy Technology Data Exchange (ETDEWEB)

    Bartke, T.C.; Fischer, D.D.; King, S.B.; Boyd, R.M.; Humphrey, A.E.

    1985-08-01

    This report is part of a seven-volume series on the Hanna, Wyoming, underground coal gasification field tests. Volume 1 is a summary of the project, and each of Volumes 2 through 6 describes a particular test. Volume 7 is a compilation of all the data for the tests in Volumes 2 through 6. Hanna II, Phase I was conducted during the spring and summer of 1975, at a site about 700 feet up dip (to the southwest) of the Hanna I test. The test was conducted in two stages - Phase IA and IB. Phase IA consisted of linking and gasification operations between Wells 1 and 3 and Phase IB of linking from the 1-3 gasification zone to Well 2, followed by a short period of gasification from Well 2 to Well 3 over a broad range of air injection rates, in order to determine system turndown capabilities and response times. This report covers: (1) site selection and characteristics; (2) test objectives; (3) facilities description; (4) pre-operational testing; (5) test operations summary; and (6) post-test activity. 7 refs., 11 figs., 8 tabs.

  18. A Hubble diagram from Type II Supernovae based solely on photometry: the Photometric-Colour Method

    CERN Document Server

    T., de Jaeger; P., Anderson J; L., Galbany; M., Hamuy; M., Phillips M; M., Stritzinger; C., Gutiérrez; L., Bolt; R., Burns C; A., Campillay; S., Castellón; C., Contreras; G., Folatelli; L., Freedman W; Y., Hsiao E; K., Krisciunas; W., Krzeminski; H., Kuncarayakti; N., Morrell; F., Olivares E; E., Persson S; N, Suntzeff

    2015-01-01

    We present a Hubble diagram of type II supernovae using corrected magnitudes derived only from photometry, with no input of spectral information. We use a data set from the Carnegie Supernovae Project I (CSP) for which optical and near-infrared light-curves were obtained. The apparent magnitude is corrected by two observables, one corresponding to the slope of the plateau in the $V$ band and the second a colour term. We obtain a dispersion of 0.44 mag using a combination of the $(V-i)$ colour and the $r$ band and we are able to reduce the dispersion to 0.39 mag using our golden sample. A comparison of our photometric colour method (PCM) with the standardised candle method (SCM) is also performed. The dispersion obtained for the SCM (which uses both photometric and spectroscopic information) is 0.29 mag which compares with 0.43 mag from the PCM, for the same SN sample. The construction of a photometric Hubble diagram is of high importance in the coming era of large photometric wide-field surveys, which will in...

  19. A HUBBLE DIAGRAM FROM TYPE II SUPERNOVAE BASED SOLELY ON PHOTOMETRY: THE PHOTOMETRIC COLOR METHOD

    Energy Technology Data Exchange (ETDEWEB)

    De Jaeger, T.; González-Gaitán, S.; Galbany, L.; Hamuy, M.; Gutiérrez, C. P.; Kuncarayakti, H. [Millennium Institute of Astrophysics, Santiago (Chile); Anderson, J. P. [European Southern Observatory, Alonso de Córdova 3107, Casilla 19, Santiago (Chile); Phillips, M. M.; Campillay, A.; Castellón, S.; Hsiao, E. Y.; Morrell, N. [Las Campanas Observatory, Carnegie Observatories, Casilla 601, La Serena (Chile); Stritzinger, M. D.; Contreras, C. [Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Bolt, L. [Argelander Institut für Astronomie, Universität Bonn, Auf dem Hgel 71, D-53111 Bonn (Germany); Burns, C. R. [Observatories of the Carnegie Institution for Science, Pasadena, CA 91101 (United States); Folatelli, G. [Instituto de Astrofísica de La Plata, CONICET, Paseo del Bosque S/N, B1900FWA, La Plata (Argentina); Freedman, W. L. [Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States); Krisciunas, K. [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); Krzeminski, W., E-mail: dthomas@das.uchile.cl [N. Copernicus Astronomical Center, ul. Bartycka 18, 00-716 Warszawa (Poland); and others

    2015-12-20

    We present a Hubble diagram of SNe II using corrected magnitudes derived only from photometry, with no input of spectral information. We use a data set from the Carnegie Supernovae Project I for which optical and near-infrared light curves were obtained. The apparent magnitude is corrected by two observables, one corresponding to the slope of the plateau in the V band and the second a color term. We obtain a dispersion of 0.44 mag using a combination of the (V − i) color and the r band and we are able to reduce the dispersion to 0.39 mag using our golden sample. A comparison of our photometric color method (PCM) with the standardized candle method (SCM) is also performed. The dispersion obtained for the SCM (which uses both photometric and spectroscopic information) is 0.29 mag, which compares with 0.43 mag from the PCM for the same SN sample. The construction of a photometric Hubble diagram is of high importance in the coming era of large photometric wide-field surveys, which will increase the detection rate of supernovae by orders of magnitude. Such numbers will prohibit spectroscopic follow up in the vast majority of cases, and hence methods must be deployed which can proceed using solely photometric data.

  20. Photoinduced hydrogen evolution with new tetradentate cobalt(ii) complexes based on the TPMA ligand.

    Science.gov (United States)

    Natali, Mirco; Badetti, Elena; Deponti, Elisa; Gamberoni, Marta; Scaramuzzo, Francesca A; Sartorel, Andrea; Zonta, Cristiano

    2016-10-07

    Hydrogen production from water splitting is nowadays recognized as a target, fundamental reaction for the production of clean fuels. Indeed, tremendous efforts have been devoted towards the research of suitable catalysts capable of performing this reaction. With respect to heterogeneous systems, molecular catalysts such as metal complexes are amenable to chemical functionalization in order to fine tune the catalytic properties. In this paper a new class of tris(2-pyridylmethyl)-amine (TPMA) cobalt(ii) complexes (CoL0-4) has been synthesized and employed as hydrogen evolving catalysts under photochemical conditions taking advantage of Ru(bpy)3(2+) (where bpy is 2,2'-bipyridine) as a light-harvesting sensitizer and ascorbic acid as a sacrificial electron donor. Tuning of the photocatalytic activity has been attempted through the introduction of different substituents at the catalyst periphery rather than through a direct chemical modification of the chelating TPMA ligand. The results show that CoL0-4 behave as competent hydrogen evolving catalysts (HECs), although the effects played by the different substituents on the catalysis are relatively modest. Possible reasons supporting the observed behavior as well as possible improvements of the aforementioned tuning approach are discussed.

  1. Synthesis, Electrochemical, Spectroscopic, Antimicrobial, and Superoxide Dismutase Activity of Nickel (II Complexes with Bidentate Schiff Bases

    Directory of Open Access Journals (Sweden)

    R. N. Patel

    2013-01-01

    Full Text Available Five new nickel (II complexes, namely, [Ni(L12](ClO42(1; [Ni(L22](ClO42(2; [Ni(L32](ClO42(3; [Ni(L42](ClO42(4; [Ni(L52](ClO42(5, where L1 = benzoylhydrazide; L2 = N-[(1-1-(2-methylphenylethylidene]benzohydrazide; L3=N-[(1-1-(4-methylphenylethylidene]benzohydrazide; L4=N-[(1-1-(2-methoxyphenylethylidene]benzohydrazide; L5 = N-[(1-1-(4-methoxy-phenylethylidene]benzohydrazide, have been synthesized and characterized by various physicochemical and spectroscopic techniques. The synthesized complexes are stable powders, insoluble in common organic solvents such as ethanol, benzene, carbon tetrachloride, chloroform, and diethyl ether, and are nonelectrolytes. The magnetic and spectroscopic data indicate a distorted square planar geometry for all complexes. The superoxide dismutase activity of these complexes has been measured and discussed. Antibacterial and antifungal properties of these complexes were also tested.

  2. Models of class II methanol masers based on improved molecular data

    CERN Document Server

    Cragg, D M; Godfrey, P D

    2005-01-01

    The class II masers of methanol are associated with the early stages of formation of high-mass stars. Modelling of these dense, dusty environments has demonstrated that pumping by infrared radiation can account for the observed masers. Collisions with other molecules in the ambient gas also play a significant role, but have not been well modelled in the past. Here we examine the effects on the maser models of newly available collision rate coefficients for methanol. The new collision data does not alter which transitions become masers in the models, but does influence their brightness and the conditions under which they switch on and off. At gas temperatures above 100 K the effects are broadly consistent with a reduction in the overall collision cross-section. This means, for example, that a slightly higher gas density than identified previously can account for most of the observed masers in W3(OH). We have also examined the effects of including more excited state energy levels in the models, and find that th...

  3. A Multi-objective Cross-training Plan Based on NSGA-II

    Directory of Open Access Journals (Sweden)

    Jun Gong

    2013-10-01

    Full Text Available The previous research on cross-training mainly focused on productive efficiency. However, enhancing labor’s satisfaction of tasks is as much important as improving production performance. This paper addresses a new cross-training policy for an assembly cell from the point of view of humanization. A multi-objective 0-1 integer programming model is presented to implement the cross-training policy for an assembly cell. The first objective works on getting to maximize average satisfaction degree, and the second objective seeks to minimize average paid salary, while determining which labors should be cross-trained on which tasks. Non-dominated sorting genetic algorithm (NSGA-II is developed to solve the model. A series of computational experiments are proceeded to explore the impact of three factors on cross-training, including labor’s preference structure, labor’s salary structure, and task redundancy. The results indicate that the balanced preference structure is better than the extreme one, the non-uniform salary structure is better than the uniform one, and the smaller task redundancy is better than the bigger one under various scenarios in the paper. Those insights can be used to direct the managers of human resource to choose the candidates for cross-training

  4. DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex

    Indian Academy of Sciences (India)

    Sarat Chandra Kumar; Abhijit Pal; Merry Mitra; V M Manikandamathavan; Chia -Her Lin; Balachandran Unni Nair; Rajarshi Ghosh

    2015-08-01

    Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and = 108.8120(10)° , = 91.2010(10)° , = 91.1500(10)° . The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 10 4 M−1 and 2.0 × 10 4 M−1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner.

  5. Copper-based nanoparticles prepared from copper (II acetate bipyridine complex

    Directory of Open Access Journals (Sweden)

    Lastovina Tatiana A.

    2016-01-01

    Full Text Available We report the synthesis of CuO, Cu/Cu2O and Cu2O/CuO nanoparticles (NPs from the single copper (II acetate bipyridine complex by three different methods:microwave-assisted, solvothermal and borohydride. Presence of bipyridine ligand in the copper complex would impose no need in additional stabilization during synthesis. The phases of formed NPs were identified by X-ray diffraction. CuO NPs of ~11 nm were obtained via solvothermal synthesis from alkaline solution at 160°C. The Cu/Cu2O NPs of ~80 nm were produced via microwave-assisted polyol procedure at 185-200°C, where ethylene glycol can play a triple role as a solvent, a reducing agent and a surfactant. The Cu2O/CuO NPs of ~16 nm were synthesized by a borohydride method at room temperature. Interplanar spacing calculated from the selected-area electron diffraction data confirmed the formation of Cu, CuO and Cu2O phases in respective samples. All NPs are stable and can be used for various applications including biomedicine.

  6. Effect of the Intervention based on Partnership Care Model on Self-Concept Promotion in Patients with Type II Diabetes

    Directory of Open Access Journals (Sweden)

    M. Sajjadi

    2017-01-01

    Full Text Available Aims: As a chronic worldwide spreading disease, diabetes negatively affects the persons’ self-concept. Since self-concept plays an important role in daily life, it should be under consideration especially in the patients with chronic diseases. The aim of the study was to determine the effects of the partnership-care model intervention on self-concept enhancement in persons with type II diabetes. Materials & Methods: In the controlled randomized clinical trial, 60 patients with type II diabetes referred to Imam Zaman Hospital were studied in Mashhad in 2015. The subjects, selected via available sampling method, were divided into two groups including control and experimental groups. Data was collected using a three-section questionnaire including demographic information, the disease information, and Beck self-concept test sections. The self-concept of the subjects having been determined, seven 90-minute partnership-care intervention sessions were conducted in experimental group. Then, the self-concept was measured in both groups. Data was analyzed by SPSS 20 software using paired T, independent T, and Chi-square tests. Findings: Before and after the intervention, the mean self-concept scores were not significantly different in control group (p=0.066. However, the difference was significant in experimental group (p<0.001. In addition, the mean scores of control and experimental groups were not significantly different before the intervention (p=0.537. Nevertheless, the mean self-concept scores of the groups were significantly different after the intervention (p<0.001. Conclusion: The intervention based on the partner-ship care model enhances the self-concept in patients with type II diabetes.

  7. Solid phase extraction and preconcentration of Cu(II), Pb(II), and Ni(II) in environmental samples on chemically modified Amberlite XAD-4 with a proper Schiff base.

    Science.gov (United States)

    Topuz, Berrin; Macit, Mustafa

    2011-02-01

    A new chelating resin, Amberlite XAD-4 loaded with N,N-bis(salicylidene)cyclohexanediamine (SCHD), was synthesized and characterized. The resin Amberlite XAD-4-SCHD was used for selective separation, preconcentration, and determination of Cu(II), Pb(II), and Ni(II) ions in water samples by flame atomic absorption spectrometry (FAAS). Effects of pH, concentration, and volume of elution solution; flow rate of elution; and sample solution, sample volume, and interfering ions for the recovery of the analytes were investigated. These metal ions can be desorbed with 0.5-M HNO3 (recovery, 98%-101%). The sorption capacity was found between 1.38×10(-1) and 3.58×10(-1) mmol/g. In order to evaluate the accuracy of the proposed procedure, the certified reference materials, BCR-032 (Moroccan phosphate rock) and BCR-715 (industrial effluent wastewater), were analyzed. The detection limits of the method were found to be 0.11, 1.91, and 0.43 μg/L for Cu(II), Pb(II), and Ni(II), respectively. The method was applied to the extraction and the recovery of copper, lead, and nickel in wastewater and other water samples.

  8. Preconcentrative separation of palladium(II) using palladium(II) ion-imprinted polymer particles formed with different quinoline derivatives and evaluation of binding parameters based on adsorption isotherm models.

    Science.gov (United States)

    Daniel, Sobhi; Babu, Prem E J; Rao, T Prasada

    2005-01-30

    Palladium(II) ion-imprinted polymer (IIP) materials were synthesized by thermally polymerizing the ternary complexes of palladium(II) with amino (AQ) or hydroxy (HQ) or mercapto (MQ) derivatives of quinoline and 4-vinyl-pyridine. The functional and crosslinking monomers used during polymerization were 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA). 2,2'-Azobisisobutyronitrile (AIBN) and 2-methoxy ethanol were used as the initiator and porogen, respectively. The resulting polymer materials were dried in an oven at 80 degrees C, ground and sieved to obtain IIP particles which were then subjected to leaching with 50% (v/v) HCl to obtain the leached palladium(II) IIP particles. Control polymer (CP) particles were also prepared by following the above procedure described for IIP particles. The CP particles, unleached and leached AQ-based IIP particles were then characterized by IR, XRD and microanalysis studies. Analytical studies such as preconcentration of palladium(II) from dilute aqueous solutions and separation studies in the presence of selected noble and base metals which co-exist with palladium(II) in its ore or mineral deposits were systematically studied using CP and IIP particles and are compared. AQ-based IIP particles gave higher percent extraction and selectivity coefficients compared to HQ- or MQ-based IIP particles. Five replicate determinations of 25mug of palladium(II) present in 500ml of aqueous solution, when subjected to preconcentration and determination by iodide-Rhodamine 6G procedure gave a mean absorbance of 0.104 with a relative standard deviation of 2.25%. The detection limit corresponding to three times the standard deviation of the blank was found to be 5.0mug of palladium(II) per litre. The rebinding studies using AQ-, HQ- and MQ-based IIPs were carried out and were fitted to the different adsorption isotherm models, viz. Langmuir (L), Freundlich (F) and Langmuir-Freundlich (LF). These adsorption models were

  9. Cu(II) complexes of an ionic liquid-based Schiff base [1-{2-(2-hydroxy benzylidene amino) ethyl}-3-methyl­imidazolium]Pf6: Synthesis, characterization and biological activities

    OpenAIRE

    Saha Sanjoy; Brahman Dhiraj; Sinha Biswajit

    2015-01-01

    Two Cu(II) complexes of an ionic liquid based Schiff base 1-{2-(2-hydroxybenzylideneamino) ethyl}-3-methylimidazolium hexaflurophosphate, were prepared and characterized by different analytical and spectroscopic methods such as elemental analysis, magnetic susceptibility, UV-Vis, IR, NMR and mass spectroscopy. The Schiff base ligand was found to act as a potential bidentate chelating ligand with N, O donor sites and formed 1:2 metal chelates with Cu(II) sal...

  10. Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited-state intramolecular proton transfer.

    Science.gov (United States)

    Henary, Maged M; Wu, Yonggang; Fahrni, Christoph J

    2004-06-21

    To develop a zinc(II)-selective emission ratiometric probe suitable for biological applications, we explored the cation-induced inhibition of excited-state intramolecular proton transfer (ESIPT) with a series of 2-(2'-benzenesulfonamidophenyl)benzimidazole derivatives. In the absence of Zn(II) at neutral pH, the fluorophores undergo ESIPT to yield a highly Stokes' shifted emission from the proton-transfer tautomer. Coordination of Zn(II) inhibits the ESIPT process and yields a significant hypsochromic shift of the fluorescence emission maximum. Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations. Due to the modular architecture of the fluorophore, the Zn(II) binding affinity can be readily tuned by implementing simple structural modifications. The synthesized probes are suitable to gauge free Zn(II) concentrations in the micromolar to picomolar range under physiological conditions.

  11. Crystal structure, characterization and magnetic properties of a 1D copper(II) polymer incorporating a Schiff base with carboxylate side arm

    Indian Academy of Sciences (India)

    SHYAMAPADA SHIT; MADHUSUDAN NANDY; CORRADO RIZZOLI; CÉDRIC DESPLANCHES; SAMIRAN MITRA

    2016-06-01

    A new 1D polymeric copper(II) complex [{Cu(L)$(CF_{3}COO)}2]_{n}$ has been synthesized using apotentially tetradentate Schiff base ligand, HL, ((E)-2-((pyridin-2-yl)methyleneamino)-5-chlorobenzoic acid)and characterized by different spectroscopic methods. Single crystal X-ray structural characterization revealsthat the side arm carboxylate group of the coordinated Schiff base exhibits a $μ_{1,3}$ -bridging mode and connectsthe neighbouring copper(II) ions leading to a zigzag 1D chain structure where the copper(II) ions displaydistorted square pyramidal geometries. Variable temperature magnetic susceptibility measurement reveals aweak antiferromagnetic exchange (J = −0.47±0.01 $cm_{−1}) prevails between copper(II) ions in the chainmediated by the bridging carboxylate group, is also supported by the room temperature EPR spectral study.Electrochemical property of the complex is also reported.

  12. Low-cost chemiresistive sensor for volatile amines based on a 2D network of a zinc(II) Schiff-base complex

    Science.gov (United States)

    Mirabella, S.; Oliveri, I. P.; Ruffino, F.; Maccarrone, G.; Di Bella, S.

    2016-10-01

    A marked chemiresistive behavior is revealed in a nanostructured material obtained by spin-coating a solution of a bis(salycilaldiminato)Zn(II) Schiff-base (ZnSB) complex. The resulting submicron 2D network exhibits reversible changes in absorbance and resistance under the cycles of absorption and desorption of a volatile amine. These results are explained in terms of a Lewis donor-acceptor interaction between the ZnSB (acceptor) and the chemisorbed amine (donor). The 2D network of ZnSB was employed as a sensing element to fabricate a low-cost device for the volatile amines detection, showing promising results for food spoilage detection.

  13. Design, spectral characterization, thermal, DFT studies and anticancer cell line activities of Co(II), Ni(II) and Cu(II) complexes of Schiff bases derived from 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol.

    Science.gov (United States)

    Tyagi, Prateek; Chandra, Sulekh; Saraswat, B S; Yadav, Deepak

    2015-06-15

    A series of two biologically active Schiff base ligands L(1), L(2) have been synthesized in equimolar reaction of 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol with thiophene-2-carbaldehyde and furan-2-carbaldehyde. The synthesized Schiff bases were used for complexation with different metal ions like Co(II), Ni(II) and Cu(II) by using a molar ratio of ligand: metal as 1:1 and 2:1. The characterization of Schiff bases and metal complexes was done by (1)H NMR, UV-Vis, TGA, IR, mass spectrometry and molar conductivity studies. The in DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6-31+g(d,p) basis set. On the basis of the spectral studies an octahedral geometry has been assigned for Co(II), Ni(II) and Cu(II) complexes. The effect of these complexes on proliferation of human breast cancer cell line (MCF-7) and human hepatocellular liver carcinoma cell line (Hep-G2) were studied and compared with those of free ligand. The anticancer cell line results reveal that all metal complexes show moderate to significant % cytotoxicity on cell line HepG2 and MCF-7.

  14. Design, spectral characterization, thermal, DFT studies and anticancer cell line activities of Co(II), Ni(II) and Cu(II) complexes of Schiff bases derived from 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

    Science.gov (United States)

    Tyagi, Prateek; Chandra, Sulekh; Saraswat, B. S.; Yadav, Deepak

    2015-06-01

    A series of two biologically active Schiff base ligands L1, L2 have been synthesized in equimolar reaction of 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol with thiophene-2-carbaldehyde and furan-2-carbaldehyde. The synthesized Schiff bases were used for complexation with different metal ions like Co(II), Ni(II) and Cu(II) by using a molar ratio of ligand: metal as 1:1 and 2:1. The characterization of Schiff bases and metal complexes was done by 1H NMR, UV-Vis, TGA, IR, mass spectrometry and molar conductivity studies. The in DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6-31+g(d,p) basis set. On the basis of the spectral studies an octahedral geometry has been assigned for Co(II), Ni(II) and Cu(II) complexes. The effect of these complexes on proliferation of human breast cancer cell line (MCF-7) and human hepatocellular liver carcinoma cell line (Hep-G2) were studied and compared with those of free ligand. The anticancer cell line results reveal that all metal complexes show moderate to significant % cytotoxicity on cell line HepG2 and MCF-7.

  15. Cu(II complexes of an ionic liquid-based Schiff base [1-{2-(2-hydroxy benzylidene amino ethyl}-3-methyl­imidazolium]Pf6: Synthesis, characterization and biological activities

    Directory of Open Access Journals (Sweden)

    Saha Sanjoy

    2015-01-01

    Full Text Available Two Cu(II complexes of an ionic liquid based Schiff base 1-{2-(2-hydroxybenzylideneamino ethyl}-3-methylimidazolium hexaflurophosphate, were prepared and characterized by different analytical and spectroscopic methods such as elemental analysis, magnetic susceptibility, UV-Vis, IR, NMR and mass spectroscopy. The Schiff base ligand was found to act as a potential bidentate chelating ligand with N, O donor sites and formed 1:2 metal chelates with Cu(II salts. The synthesized Cu(II complexes were tested for biological activity.

  16. Concurrent and adjuvant temozolomide-based chemoradiotherapy schedules for glioblastoma. Hypotheses based on two prospective phase II trials

    Energy Technology Data Exchange (ETDEWEB)

    Balducci, M. [Catholic Univ. of the Sacred Heart, Rome (Italy). Dept. of Radiation Oncology; Fiorentino, A. [IRCCS/CROB, Rionero in Vulture (Italy). Dept. of Radiation Oncology; De Bonis, P. [Catholic Univ. of the Sacred Heart, Rome (Italy). Dept. of Neurosurgery; and others

    2013-11-15

    Aim: To investigate the impact of nonstandard concomitant temozolomide (TMZ) administration in two prospective phase II studies for glioblastoma (GBM). Patients and methods: From October 2000 to June 2008, 104 patients were enrolled in two studies: 25 in RT-TMZ-10.00 and 79 in RT-TMZ-01.04. Adjuvant radiotherapy (RT) was used with a total dose of 59.4 Gy (1.8 Gy/day). Patients received concomitant TMZ (75 mg/m{sup 2}/day) from Monday to Friday during the first and last weeks of RT in the RT-TMZ-10.00 study and from Monday to Friday during all weeks of RT in the RT-TMZ-01.04 trial. Adjuvant TMZ (200 mg/m{sup 2}) was administered for 5 days every 28 days. Results: Median progression-free (PFS) and overall survival (OS) were 9 and 16 months, respectively, with no significant difference between the two groups (p = 0.5 and 0.14, respectively). The 2- and 5-year OS rates were 32 and 3 %, respectively, and similar to those observed with standard treatment regimens. Conclusion: Our data support the hypothesis that adjuvant TMZ is more important than concomitant chemotherapy (CH) and that RT is the more important element of the concomitant treatment schedule. (orig.)

  17. Dimensional optimization of a minimally invasive surgical robot system based on NSGA-II algorithm

    National Research Council Canada - National Science Library

    Wang, Wei; Wang, Weidong; Dong, Wei; Yu, Hongjian; Yan, Zhiyuan; Du, Zhijiang

    2015-01-01

    Based on the proposed end-effector structure of a laparoscopic minimally invasive surgical manipulator, a dimensional optimization method is investigated to enlarge the motion range of the mechanical...

  18. Synthesis, Characterisation and Structural Studies of Complexes Containing Different Schiff Bases with Mn (Lll And Mn (Ii Transition Metals

    Directory of Open Access Journals (Sweden)

    Gulrez Nizami

    2014-01-01

    Full Text Available The Schiff bases 5-methyl2-hydroxyacetophenonemorpholine-N-thiohydrazide, 5-methyl2-hydroxyacetophenoneantipyrine 5-chloro2-hydroxyacetophenonemorpholine-N-thiohydrazone has reacted with MnII and MnIII to form co-ordination compounds having general formula [M (C14H19O2N3S 3H2O] Cl; [M (C14H19O2N3S.3H2O]; [M (C20H20N3O2 2] Cl; [M (C20H20N3O2 2];[M(C13H14O2N3SCl.3H2O]Cl and [M(C13H14O2N3SCl].3H2 O] respectively. Where M=Mn III and Mn II. The adducts have been characterized on the basis of elemental analyses molar conductance, I.R , visible spectra, magnetic susceptibility measurement and TGA. The ligands behave in dibasic tridentate manner in 5-methyl2-hydroxyacetophenonemorpholine-N-thiohydrazone and 5-chloro2-hydroxyacetophenonemorpholine-N-thiohydrazone.While5-methyl2hydroxyacetophenoneantipyrine behaves in monobasic tridentate manner. All these compounds are paramagnetic in nature and have octahedral geometry.

  19. Exploration of the structural features and magnetic behaviour in a novel 3-dimensional interpenetrating Co(II)-based framework

    Indian Academy of Sciences (India)

    Soumyabrata Goswami; Amit Kumar Mondal; Sanjit Konar

    2015-02-01

    A new Co(II)-based three-dimensional (3D) framework having the molecular formula [Co(C4O4)(4-bpmh))H2O)2]n·2nH2O·2nMeOH·(1)(4-bpmh = N, N-bis-pyridin-4-ylmethylene-hydrazine) has been synthesized using a mixed ligand system and characterized by elemental analysis, IR spectroscopy, thermogravimetric analysis, single crystal X-ray diffraction and variable temperature magnetic study. The framework is constructed by the bridging squarate (C4O2−4) and N, N-bis-pyridin-4-ylmethylene-hydrazine (4-bpmh) ligands and interpenetration of the 2D grid-like frameworks at definite angles gives rise to 2D→3D inclined polycatenation with sql/Shubnikov tetragonal plane net topology. Extensive non-covalent interactions (H-bonding as well as $\\cdots$ interactions) are also observed which stabilises the 3D arrangement. Additionally, complex 1 contains 1D channels of large dimensions (10.91 × 11.78 Å2) that runs along the b-axis. Variable temperature DC magnetic susceptibility study reveals dominant spin–orbit coupling effect typical of the 4T1g ground state of octahedral high-spin Co(II) ion at a higher temperature range.

  20. Synthesis, Structural Diversity and Mimic Superoxide Dismutase of Mn(II) Complexes Derived from N, O-donor Schiff bases.

    Science.gov (United States)

    Qin, Jie; Yin, Qiang; Zhao, Shan-Shan; Wang, Jun-Zheng; Qian, Shao-Song

    2016-01-01

    Two new potentially tetradentate Schiff base ligands N'-(pyridin-2-ylmethylene)nicotinohydrazide (L1), and N'-(pyridin-2-ylmethylene)isonicotinohydrazide (L(2)) were synthesized. Reactions of hydrazone ligands L(1) and L(2) with Mn(NO(3))(2) afford two mononuclear Mn(II) complexes, [Mn(L(1))(NO(3))(H(2)O)(2)]•(NO(3)) (1) and [Mn(L(2))(2)(NO(3))(H(2)O)]•(NO(3)) (2). For complexes 1 and 2, L(1) and L(2) act as pincer-like tridentate or bidentate ligands, respectively. The Mn(II) ions in the two compounds are both in heptacoordinated environment, while the two molecules display diverse solid-state supramolecular structures because of the different orientation of Npyridine and hydrogen bonding patterns of nitrate anions. Complex 1 features 2D supramolecular sheet, while complex 2 is double-chain supramolecular structure. Both of the two complexes exhibit moderate superoxide dismutase (SOD) mimetic activity.

  1. A structure-based model of energy transfer reveals the principles of light harvesting in photosystem II supercomplexes.

    Science.gov (United States)

    Bennett, Doran I G; Amarnath, Kapil; Fleming, Graham R

    2013-06-19

    Photosystem II (PSII) initiates photosynthesis in plants through the absorption of light and subsequent conversion of excitation energy to chemical energy via charge separation. The pigment binding proteins associated with PSII assemble in the grana membrane into PSII supercomplexes and surrounding light harvesting complex II trimers. To understand the high efficiency of light harvesting in PSII requires quantitative insight into energy transfer and charge separation in PSII supercomplexes. We have constructed the first structure-based model of energy transfer in PSII supercomplexes. This model shows that the kinetics of light harvesting cannot be simplified to a single rate limiting step. Instead, substantial contributions arise from both excitation diffusion through the antenna pigments and transfer from the antenna to the reaction center (RC), where charge separation occurs. Because of the lack of a rate-limiting step, fitting kinetic models to fluorescence lifetime data cannot be used to derive mechanistic insight on light harvesting in PSII. This model will clarify the interpretation of chlorophyll fluorescence data from PSII supercomplexes, grana membranes, and leaves.

  2. Two novel Co(II complexes with two different Schiff bases: inhibiting growth of human skin cancer cells

    Directory of Open Access Journals (Sweden)

    Y.-J. Xiao

    Full Text Available Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II-coordination compounds, namely, Py3CoL1 (1 and Py3CoL2 (2 (Py=pyridine, L1=3,5-ClC6H2(OC=NC6H3(O-4-NO2, L2=3,5-BrC6H2(OC=NC6H3(O-4-NO2 have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30 were used in the screening tests.

  3. Mn(II)-based porous metal-organic framework showing metamagnetic properties and high hydrogen adsorption at low pressure.

    Science.gov (United States)

    Han, Zheng-Bo; Lu, Rui-Yun; Liang, Yan-Fang; Zhou, Yan-Ling; Chen, Qing; Zeng, Ming-Hua

    2012-01-02

    A Mn(II)-based homometallic porous metal-organic framework, Mn(5)(btac)(4)(μ(3)-OH)(2)(EtOH)(2)·DMF·3EtOH·3H(2)O (1, btac = benzotriazole-5-carboxylate), has been solvothermally synthesized and structurally characterized by elemental analysis, thermogravimetric analysis, and X-ray crystallographic study. 1 is a 3D neutral framework featuring 1D porous channels constructed by {Mn-OH-Mn}(n) chains and btac linkers. Magnetic studies show that 1 is a 3D metamagnet containing 1D {Mn-OH-Mn}(n) ferrimagnetic chains. High-pressure H(2) adsorption measurement at 77 K reveals that activated 1 can absorb 0.99 wt % H(2) at 0.5 atm and reaches a maximum of 1.03 wt % at 5.5 atm. The steep H(2) absorption at lower pressure (98.2% of the storage capacity at 0.5 atm) is higher than the corresponding values of some MOFs (MIL-100 (16.1%), MOF-177 (57.1%), and MOF-5 (22.2%)). Furthermore, activated 1 can adsorb CO(2) at room temperature and 275 K. The adsorption enthalpy is 22.0 kJ mol(-1), which reveals the high binding ability for CO(2). Detailed gas sorption implies that the exposed Mn(II) coordination sites in the activated 1 play an important role to improve its adsorption capacities.

  4. Bases conceptuales y metodológicas de la Encuesta Nacional de Salud II, México 1994

    Directory of Open Access Journals (Sweden)

    1998-01-01

    Full Text Available Se describen las bases conceptuales y metodológicas de la Encuesta Nacional de Salud II (ENSA-II, que integra avances de la investigación multidisciplinaria en salud pública, tanto en el terreno conceptual como en el metodológico, que se han dado en nuestro país últimamente. Su diseño se concentró particularmente en las condiciones del acceso, la calidad y los costos de los servicios de atención a la salud, tanto a nivel ambulatorio como hospitalario. Se incluyen detalles de su marco conceptual, así como los aspectos relacionados con el procesamiento y análisis. La cobertura geográfica fue hecha para cinco regiones; se visitaron 12 615 viviendas a escala nacional, y se recabó información sobre 61 524 individuos. La tasa global de respuesta fue de 96.7%, tanto para los hogares como para los utilizadores identificados de servicios de salud. La conclusión general apunta hacia la incorporación del enfoque de la población al proceso de planeación y asignación de recursos para la atención a la salud.

  5. Can copper(II) mediate Hoogsteen base-pairing in a left-handed DNA duplex? A pulse EPR study.

    Science.gov (United States)

    Santangelo, Maria Grazia; Antoni, Philipp M; Spingler, Bernhard; Jeschke, Gunnar

    2010-02-22

    Pulse EPR spectroscopy is used to investigate possible structural features of the copper(II) ion coordinated to poly(dG-dC).poly(dG-dC) in a frozen aqueous solution, and the structural changes of the polynucleotide induced by the presence of the metal ion. Two different copper species were identified and their geometry explained by a molecular model. According to this model, one species is exclusively coordinated to a single guanine with the N7 nitrogen atom forming a coordinative bond with the copper. In the other species, a guanine and a cytosine form a ternary complex together with the copper ion. A copper crosslink between the N7 of guanine and N3 of cytosine is proposed as the most probable coordination site. Moreover, no evidence was found for an interaction of either copper species with a phosphate group or equatorial water molecules. In addition, circular dichroism (CD) spectroscopy showed that the DNA of the Cu(II)-poly(dG-dC).poly(dG-dC) adducts resembles the left-handed Z-form. These results suggest that metal-mediated Hoogsteen base pairing, as previously proposed for a right-handed DNA duplex, can also occur in a double-stranded left-handed DNA.

  6. Doubtful outcome of the validation of the Rome II questionnaire: validation of a symptom based diagnostic tool

    Directory of Open Access Journals (Sweden)

    Nylin Henry BO

    2009-12-01

    Full Text Available Abstract Background Questionnaires are used in research and clinical practice. For gastrointestinal complaints the Rome II questionnaire is internationally known but not validated. The aim of this study was to validate a printed and a computerized version of Rome II, translated into Swedish. Results from various analyses are reported. Methods Volunteers from a population based colonoscopy study were included (n = 1011, together with patients seeking general practice (n = 45 and patients visiting a gastrointestinal specialists' clinic (n = 67. The questionnaire consists of 38 questions concerning gastrointestinal symptoms and complaints. Diagnoses are made after a special code. Our validation included analyses of the translation, feasibility, predictability, reproducibility and reliability. Kappa values and overall agreement were measured. The factor structures were confirmed using a principal component analysis and Cronbach's alpha was used to test the internal consistency. Results and Discussion Translation and back translation showed good agreement. The questionnaire was easy to understand and use. The reproducibility test showed kappa values of 0.60 for GERS, 0.52 for FD, and 0.47 for IBS. Kappa values and overall agreement for the predictability when the diagnoses by the questionnaire were compared to the diagnoses by the clinician were 0.26 and 90% for GERS, 0.18 and 85% for FD, and 0.49 and 86% for IBS. Corresponding figures for the agreement between the printed and the digital version were 0.50 and 92% for GERS, 0.64 and 95% for FD, and 0.76 and 95% for IBS. Cronbach's alpha coefficient for GERS was 0.75 with a span per item of 0.71 to 0.76. For FD the figures were 0.68 and 0.54 to 0.70 and for IBS 0.61 and 0.56 to 0.66. The Rome II questionnaire has never been thoroughly validated before even if diagnoses made by the Rome criteria have been compared to diagnoses made in clinical practice. Conclusion The accuracy of the Swedish version of

  7. Enhancing physical activity in older adults receiving hospital based rehabilitation: a phase II feasibility study

    Directory of Open Access Journals (Sweden)

    Said Catherine M

    2012-06-01

    Full Text Available Abstract Background Older adults receiving inpatient rehabilitation have low activity levels and poor mobility outcomes. Increased physical activity may improve mobility. The objective of this Phase II study was to evaluate the feasibility of a randomized controlled trial (RCT of enhanced physical activity in older adults receiving rehabilitation. Methods Patients admitted to aged care rehabilitation with reduced mobility were randomized to receive usual care or usual care plus additional physical activity, which was delivered by a physiotherapist or physiotherapy assistant. The feasibility and safety of the proposed RCT protocol was evaluated. The primary clinical outcome was mobility, which was assessed on hospital admission and discharge by an assessor blinded to group assignment. To determine the most appropriate measure of mobility, three measures were trialled; the Timed Up and Go, the Elderly Mobility Scale and the de Morton Mobility Index. Results The protocol was feasible. Thirty-four percent of people admitted to the ward were recruited, with 47 participants randomised to a control (n = 25 or intervention group (n = 22. The rates of adverse events (death, falls and readmission to an acute service did not differ between the groups. Usual care therapists remained blind to group allocation, with no change in usual practice. Physical activity targets were met on weekdays but not weekends and the intervention was acceptable to participants. The de Morton Mobility Index was the most appropriate measure of mobility. Conclusions The proposed RCT of enhanced physical activity in older adults receiving rehabilitation was feasible. A larger multi-centre RCT to establish whether this intervention is cost effective and improves mobility is warranted. Trial registration The trial was registered with the ANZTCR (ACTRN12608000427370.

  8. Theoretical and experimental studies of Cu(II) and Zn(II) coordination compounds with N,O donor bidentate Schiff base ligand containing amino phenol moiety

    Science.gov (United States)

    Kusmariya, Brajendra S.; Tiwari, Anjali; Mishra, A. P.; Naikoo, Gowhar Ahmad

    2016-09-01

    We report here two mononuclear Cu(II) and Zn(II) coordination compounds of general formula [CuII(L)2].2H2O (1) and [ZnII(L)2].3H2O (2) derived from bidentate 2-chloro-6-{[(4-hydroxy-3-methoxyphenyl)methylidene]amino}-4 nitrophenol ligand (HL). These compounds were synthesized and characterized by elemental analysis, FT-IR, uv-vis, 1H NMR, molar conductance, thermal, PXRD, SEM-EDX and electrochemical studies. The PXRD and SEM analysis shows the amorphous/nanocrystalline nature of 1 and crystalline nature of 2. The diffraction peak broadening was explained in terms of domain size and the crystallite lattice strain. Thermogravimetric analysis in the range of 300-1172 K has been performed to determine the thermal stability of synthesized compounds. The non-isothermal kinetic parameters of degradation process were calculated using Coats-Redfern (C-R), Piloyan-Novikova (P-N) and Horowitz-Metzger (H-M) methods assuming first order degradation and proposed a random nucleation mechanism of thermal decomposition for both compounds. The cyclic voltammetric studies reveal the irreversibility of the oxidation/reduction process of synthesized compounds. To support the experimental findings theoretical calculations by means of DFT and TD-DFT at B3LYP level were incorporated. In addition; frequency calculations, HOMO-LUMO, energy gap (ΔE), molecular electrostatic potential (MEP), spin density and crystal packing were also computed at the same level of theory.

  9. Biologically active new Fe(II, Co(II, Ni(II, Cu(II, Zn(II and Cd(II complexes of N-(2-thienylmethylenemethanamine

    Directory of Open Access Journals (Sweden)

    C. SPÎNU

    2008-04-01

    Full Text Available Iron(II, cobalt(II, nickel (II, copper (II, zinc(II and cadmium(II complexes of the type ML2Cl2, where M is a metal and L is the Schiff base N-(2-thienylmethylenemethanamine (TNAM formed by the condensation of 2-thiophenecarboxaldehyde and methylamine, were prepared and characterized by elemental analysis as well as magnetic and spectroscopic measurements. The elemental analyses suggest the stoichiometry to be 1:2 (metal:ligand. Magnetic susceptibility data coupled with electronic, ESR and Mössbauer spectra suggest a distorted octahedral structure for the Fe(II, Co(II and Ni(II complexes, a square-planar geometry for the Cu(II compound and a tetrahedral geometry for the Zn(II and Cd(II complexes. The infrared and NMR spectra of the complexes agree with co-ordination to the central metal atom through nitrogen and sulphur atoms. Conductance measurements suggest the non-electrolytic nature of the complexes, except for the Cu(II, Zn(II and Cd(II complexes, which are 1:2 electrolytes. The Schiff base and its metal chelates were screened for their biological activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the metal chelates were found to possess better antibacterial activity than that of the uncomplexed Schiff base.

  10. Click on silica: systematic immobilization of Co(II) Schiff bases to the mesoporous silica via click reaction and their catalytic activity for aerobic oxidation of alcohols.

    Science.gov (United States)

    Rana, Bharat S; Jain, Suman L; Singh, Bhawan; Bhaumik, Asim; Sain, Bir; Sinha, Anil K

    2010-09-07

    The systematic immobilization of cobalt(II) Schiff base complexes on SBA-15 mesoporous silica via copper catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) "click reaction" involving either step-wise synthesis of silica-bound Schiff base ligand followed by its subsequent complexation with cobalt ions, or by the direct immobilization of preformed Co(II) Schiff base complex to the silica support is described. The catalytic activity of the prepared complexes was studied for the oxidation of alcohols to carbonyl compounds using molecular oxygen as oxidant. The immobilized complexes were recycled for several runs without loss in catalytic activity and no leaching was observed during this course.

  11. MODELING OF NI-CR-MO BASED ALLOYS: PART II - KINETICS

    Energy Technology Data Exchange (ETDEWEB)

    Turchi, P A; Kaufman, L; Liu, Z

    2006-07-07

    The CALPHAD approach is applied to kinetic studies of phase transformations and aging of prototypes of Ni-Cr-Mo-based alloys selected for waste disposal canisters in the Yucca Mountain Project (YMP). Based on a previous study on alloy stability for several candidate alloys, the thermodynamic driving forces together with a newly developed mobility database have been used to analyze diffusion-controlled transformations in these Ni-based alloys. Results on precipitation of the Ni{sub 2}Cr-ordered phase in Ni-Cr and Ni-Cr-Mo alloys, and of the complex P- and {delta}-phases in a surrogate of Alloy 22 are presented, and the output from the modeling are compared with experimental data on aging.

  12. Selective determination of trace copper(II) by cathodic adsorptive stripping voltammetry with a naphthol-derivative Schiff's base.

    Science.gov (United States)

    Shamsipur, Mojtaba; Saeidi, Mahboubeh; Sharghi, Hashem; Naeimi, Hossein

    2003-01-01

    A selective and sensitive stripping voltammetric method for the determination of trace amounts of copper(II) with a recently synthesized naphthol-derivative Schiff's base (2,2'-[1,2-ethanediylbis(nitriloethylidyne)]bis(1-naphthalene)) is presented. The method is based on adsorptive accumulation of the resulting copper-Schiff's base complex on a hanging mercury drop electrode, followed by the stripping voltammetric measurement at the reduction current of adsorbed complex at -0.15 V (vs. Ag/AgCl). The optimal conditions for the stripping analysis of copper include pH 5.5 to 6.5, 8 microM Schiff's base and an accumulation potential of -0.05 V (vs. Ag/AgCI). The peak current is linearly proportional to the copper concentration over a range 2.3-50.8 ng ml(-1) with a limit of detection of 1.9 ng ml(-1). The accumulation time and RSD are 90 s and (3.2-3.5)%, respectively. The method was applied to the determination of copper in some analytical grade salts, tap water, human serum and sheep's liver.

  13. Cobalt(II/III) redox electrolyte in ZnO nanowire-based dye-sensitized solar cells.

    Science.gov (United States)

    Fan, Jiandong; Hao, Yan; Cabot, Andreu; Johansson, Erik M J; Boschloo, Gerrit; Hagfeldt, Anders

    2013-03-01

    In this work, we explore the use of cobalt complex redox shuttles in dye sensitized solar cells (DSCs) based on ZnO nanowires (NWs). Arrays of vertically aligned ZnO NWs produced by a low-cost hydrothermal method are used to fabricate DSCs with [Co(bpy)3](2+/3+) as electrolyte. A direct comparison of the performance of [Co(bpy)3](2+/3+)-based ZnO DSC with I(-)/I3(-)-based ones demonstrates the higher suitability of the cobalt complex, both in terms of a larger open circuit voltage (VOC) and a higher photocurrent. The [Co(bpy)3](2+/3+) electrolyte results in VOC enhancements above 200 mV. This VOC increase is associated to the better match between the cobalt complex redox potential and the oxidation potential of the dye. The incident photon-to-current efficiency (IPCE) enhancement is attributed to a less competitive visible light absorption of the cobalt redox couple. Thus the present study opens new opportunities to improve energy conversion efficiency in ZnO-based DSCs.

  14. Mobile group II intron based gene targeting in Lactobacillus plantarum WCFS1.

    Science.gov (United States)

    Sasikumar, Ponnusamy; Paul, Eldho; Gomathi, Sivasamy; Abhishek, Albert; Sasikumar, Sundaresan; Selvam, Govindan Sadasivam

    2016-10-01

    The usage of recombinant lactic acid bacteria for delivery of therapeutic proteins to the mucosa has been emerging. In the present study, an attempt was made to engineer a thyA mutant of Lactobacillus plantarum (L. plantarum) using lactococcal group II intron Ll.LtrB for the development of biologically contained recombinant L. plantarum for prevention of calcium oxalate stone disease. The 3 kb Ll.LtrB intron donor cassettes from the source vector pACD4C was PCR amplified, ligated into pSIP series of lactobacillus vector pLp_3050sAmyA, yielding a novel vector pLpACD4C (8.6 kb). The quantitative real-time PCR experiment shows 94-fold increased expression of Ll.LtrB intron and 14-fold increased expression of ltrA gene in recombinant L. plantarum containing pLpACD4C. In order to target the thyA gene, the potential intron RNA binding sites in the thyA gene of L. plantarum was predicted with help of computer algorithm. The insertion location 188|189s of thyA gene (lowest E-0.134) was chosen and the wild type intron Ll.LtrB was PCR modified, yielding a retargeted intron of pLpACDthyA. The retargeted intron was expressed by using induction peptide (sppIP), subsequently the integration of intron in thyA gene was identified by PCR screening and finally ThyA(-) mutant of L. plantarum (ThyA18) was detected. In vitro growth curve result showed that in the absence of thymidine, colony forming units of mutant ThyA18 was decreased, whereas high thymidine concentration (10 μM) supported the growth of the culture until saturation. In conclusion, ThyA(-) mutant of L. plantarum (ThyA18) constructed in this study will be used as a biologically contained recombinant probiotic to deliver oxalate decarboxylase into the lumen for treatment of hyperoxaluria and calcium oxalate stone deposition.

  15. Structure-Triggered High Quantum Yield Luminescence and Switchable Dielectric Properties in Manganese(II) Based Hybrid Compounds.

    Science.gov (United States)

    Wang, Zhong-Xia; Li, Peng-Fei; Liao, Wei-Qiang; Tang, Yuanyuan; Ye, Heng-Yun; Zhang, Yi

    2016-04-01

    Two new manganese(II) based organic-inorganic hybrid compounds, C11H21Cl3MnN2 (1) and C11H22Cl4MnN2 (2), with prominent photoluminescence and dielectric properties were synthesized by solvent modulation. Compound 1 with novel trigonal bipyramidal geometry exhibits bright red luminescence with a lifetime of 2.47 ms and high quantum yield of 35.8 %. Compound 2 with tetrahedral geometry displays intense long-lived (1.54 ms) green light emission with higher quantum yield of 92.3 %, accompanied by reversible solid-state phase transition at 170 K and a distinct switchable dielectric property. The better performance of 2 results from the structure, including a discrete organic cation moiety and inorganic metal anion framework, which gives the cations large freedom of motion.

  16. Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties.

    Science.gov (United States)

    Reddy, Pulimamidi Rabindra; Rajeshwar, Suryam; Satyanarayana, Battu

    2016-07-01

    Three mononuclear Cu(II) complexes [Cu(naph-phe)phen] (1), [Cu(naph-tyr)(phen)] (2) and [Cu(naph-trp)(phen)] (3) were synthesized, characterized and their biological properties were studied. Complexes 1, 2, 3 exhibit square pyramidal geometry where Schiff base acts as a binegative tridentate ONO donor ligand and phen acts as NN donor ligand. CT-DNA binding studies revealed that the complexes bind through intercalative mode and show good binding propensity. The hydrolytic DNA cleavage activity of these complexes has been studied using gel electrophoresis. The DNA binding and cleavage affinities decrease in the order of 3>2>1. The in-vitro antimicrobial activities of the complexes were also studied.

  17. The prognostic importance of miR-21 in stage II colon cancer: a population-based study

    DEFF Research Database (Denmark)

    Kjaer-Frifeldt, S.; Hansen, T. F.; Nielsen, B. S.

    2012-01-01

    R-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient......-free cancer-specific survival (RF-CSS): HR = 1.26; 95% CI: 1.15-1.60; P analysis, a high level of miR-21 retained its prognostic importance and was found to be significantly related to poor RF-CSS: HR 1.41; 95% CI: 1.19-1.67; P ... was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence...

  18. Preparation and Biological Evaluation of Two Novel Platinum(II Complexes Based on the Ligands of Dipicolyamine Bisphosphonate Esters

    Directory of Open Access Journals (Sweden)

    Ling Qiu

    2016-02-01

    Full Text Available Two new platinum(II-based complexes bearing a bone-targeting group were synthesized and characterized. They both have excellent affinity for hydroxyapatite (HA, which is abundant in human bone tissues. Their antitumor activities against five human cancer cell lines (U2OS, A549, HCT116, MDA-MB-231 and HepG2 were evaluated and compared with cisplatin (CDDP. Though the antitumor efficacies of new complexes are lower than that of CDDP, they show higher selectivity against the HepG2 hepatoma cell line than the L02 normal liver cell line. Morphology studies exhibited typical characteristics of cell apoptosis and the cell cycle distribution analysis indicated that the complexes can inhibit cancer cells by inducing cell cycle arrest at the G2/M phase, a similar mechanism of action to CDDP.

  19. A multicriteria model for ranking of improvement approaches in construction companies based on the PROMETHÉE II method

    Directory of Open Access Journals (Sweden)

    Renata Maciel de Melo

    2015-03-01

    Full Text Available The quality of the construction production process may be improved using several different methods such as Lean Construction, ISO 9001, ISO 14001 or ISO 18001. Construction companies need a preliminary study and systematic implementation of changes to become more competitive and efficient. This paper presents a multicriteria decision model for the selection and ranking of such alternatives for improvement approaches regarding the aspects of quality, sustainability and safety, based on the PROMETHEE II method. The adoption of this model provides more confidence and visibility for decision makers. One of the differentiators of this model is the use of a fragmented set of improvement alternatives. These alternatives were combined with some restrictions to create a global set of alternatives. An application to three scenarios, considering realistic data, was developed. The results of the application show that the model should be incorporated into the strategic planning process of organizations.

  20. Photoluminiscence response of Ru(II) complex immobilized in SiO2-based matrix to dissolved oxygen in beer.

    Science.gov (United States)

    Anastasova, S; Milanova, M; Todorovsky, D

    2008-04-24

    The possibility to use the photoluminescence of Ru(II) tris(4,7-diphenyl-1,10-phenathroline) dichloride, immobilized in sol-gel produced SiO2-based matrix for the determination of dissolved oxygen concentration in beer is studied. Organically-modified silane (octyltriethoxysilane) and mixtures from tetraethoxysilane and octyltriethoxysilane are used as precursors for matrix production. Spin- and dip-coating techniques are applied for films deposition. The predeposition ultrasound treatment of the sol ensures a good sensitivity and a linear sensor quenching response to oxygen in 1/6 ppm O2-concentration interval. The CO2 present practically has no effect on the films performance. Their photoluminescence show rather good stability on prolonged storage in beer.

  1. Phase II final report and second update of the energy economic data base (EEDB) program. Volume 1 of 1

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The Energy Economic Data Base (EEDB) Program deals with the development of cost data for nuclear and comparison electric power generating stations. The objective of the USDOE EEDB Program is to provide periodic updates of technical and cost (capital, fuel and operating and maintenance) information of significance to the US Department of Energy. This information is intended to be used by USDOE in evaluating and monitoring US Civilian nuclear power programs, and to provide them with a consistent means of evaluating the nuclear option against alternatives. This report presents the Second Update of the EEDB for a cost and regulation date of January 1, 1979, prepared during Phase II of the EEDB Program. The Second Update is the first of a series of periodic updates marking the beginning of the next step in meeting the objective of the EEDB Program.

  2. Impact of Lewis base on chemical reactivity and separation efficiency for hydrated fourth-row transition metal (II) complexes: an ONIOM DFT/MM study.

    Science.gov (United States)

    He, Dingsheng; Ma, Ming

    2014-04-24

    In this paper, two-layer ONIOM combinations of high-level quantum mechanics (QM) and inexpensive molecular mechanics (MM) are successfully used to investigate the structural characters of metal (M, all the transition metals in the fourth period)-H2O-Lewis base (A(-)) complexes. Global and local descriptors of chemical reactivity and selectivity from conceptual density functional theory are employed to show the properties of the active complexes of M(H2O)2A2 and to study the effect of the Lewis base for the separation of transition metal ions. It is shown that chemical potential, hardness, electrophilicity, as well as the dual and multiphilic descriptors are adequate for characterizing the global and local reactivity trends of the M(H2O)2A2 complex. It is found that the reactivity is well localized at the metallic center in M(H2O)2A2 and the dual descriptor (ΔfM(r)) can also be used to characterize the directional attack of the electrophile and nucleophile except for the selectivity of the reaction. On the basis of the values of ωM and Δsk, and the sign of ΔfM(r), the selectivity of the nucleophilic reagent (R(-)) for M(II) in M(H2O)2A2 (from high to low) follows this order: Cu(II) > Ni(II) > Co(II) > Fe(II) ≫ Mn(II) > Zn(II) > Cr(II). The Lewis base (A(-)) improves chemical reactivity and selectivity because of changing the reaction path and forming an intermediate, which possesses the higher antibonding character and the larger HOMO/LUMO gap. NBO or AIMALL analysis and Frontier orbital theory results presented here provided more theoretical support for the above reactivity and selectivity studies.

  3. SYNTHESIS, CHARACTERIZATION AND CATALYTIC ACTIVITY OF N,N'-BIS(3-ALLYL SALICYLIDENE)ETHYLENEDIAMINE COBALT(II) SCHIFF BASE COMPLEX ANCHORED ON A NEW POLYMER SUPPORT

    Institute of Scientific and Technical Information of China (English)

    K.C. Gupta; H.K. Abdulkadir; S. Chand

    2004-01-01

    A new chelating polymer support has been prepared by suspension copolymeriz a tion of synthesized N,N'-bis(3-allyl salicylidene)ethylenediamine monomer Schiff base (N,N'-BSEDA) with styrene (St) and divinylbenzene (DVB) using azobisisobutyronitrile (AIBN) as initiator in the presence of poly(vinyl alcohol). The content and complexation ability of monomer Schiff base (N,N'-BSEDA) for cobalt(II) ions in prepared crosslinked polymer beads have shown dependence on the amount of DVB used in reaction mixture. The amount of monomer Schiff base (N,N'-BSEDA) in crosslinked beads showed a substantial decreasing trend at high concentration of DVB in the reaction mixture (> 1.5 mol dm-3), hence the efficiency of complexation (EC%) and cobalt(II) ion loading (EL%) of polymer beads showed a decreasing trend. The structure of monomer Schiff base (N,N'-BSEDA) and its cobalt(II) complex on polymer support was elucidated by IR, UV and magnetic measurements. The catalytic activity of polymer bound cobalt(Ⅱ) Schiff base complex was evaluated by analyzing kinetic data of decomposition of hydrogen peroxide in the presence of either supported cobalt (II) complex or free cobalt(II) complex. The activation energy for the decomposition of hydrogen peroxide by polymer supported cobalt(II)complex was found to be low (33.37 kJ mol-l) in comparison with unsupported cobalt(II) complex (56.35 kJ mol-1). On the basis of experimental observations, reaction steps are proposed and a suitable rate expression derived.

  4. Dihedral-based segment identification and classification of biopolymers II: polynucleotides.

    Science.gov (United States)

    Nagy, Gabor; Oostenbrink, Chris

    2014-01-27

    In an accompanying paper (Nagy, G.; Oostenbrink, C. Dihedral-based segment identification and classification of biopolymers I: Proteins. J. Chem. Inf. Model. 2013, DOI: 10.1021/ci400541d), we introduce a new algorithm for structure classification of biopolymeric structures based on main-chain dihedral angles. The DISICL algorithm (short for DIhedral-based Segment Identification and CLassification) classifies segments of structures containing two central residues. Here, we introduce the DISICL library for polynucleotides, which is based on the dihedral angles ε, ζ, and χ for the two central residues of a three-nucleotide segment of a single strand. Seventeen distinct structural classes are defined for nucleotide structures, some of which--to our knowledge--were not described previously in other structure classification algorithms. In particular, DISICL also classifies noncanonical single-stranded structural elements. DISICL is applied to databases of DNA and RNA structures containing 80,000 and 180,000 segments, respectively. The classifications according to DISICL are compared to those of another popular classification scheme in terms of the amount of classified nucleotides, average occurrence and length of structural elements, and pairwise matches of the classifications. While the detailed classification of DISICL adds sensitivity to a structure analysis, it can be readily reduced to eight simplified classes providing a more general overview of the secondary structure in polynucleotides.

  5. A criterion of normality based on a single holomorphic function II

    CERN Document Server

    Liu, Xiaojun

    2011-01-01

    In this paper, we continue to discuss normality based on a single\\linebreak holomorphic function. We obtain the following result. Let $\\CF$ be a family of functions holomorphic on a domain $D\\subset\\mathbb C$. Let $k\\ge2$ be an integer and let $h(\

  6. Equilibrium II: Acids and Bases. Independent Learning Project for Advanced Chemistry (ILPAC). Unit P3.

    Science.gov (United States)

    Inner London Education Authority (England).

    This unit on equilibrium is one of 10 first year units produced by the Independent Learning Project for Advanced Chemistry (ILPAC). The unit, which consists of two levels, focuses on the application of equilibrium principles to equilibria involving weak acids and bases, including buffer solutions and indicators. Level one uses Le Chatelier's…

  7. Collection evaluation in University libraries (II. Methods based on collection use

    Directory of Open Access Journals (Sweden)

    Àngels Massísimo i Sánchez de Boado

    2004-01-01

    Full Text Available This is our second paper devoted to the collection evaluation in the university libraries. Seven methods are described, based on collection use. Their advantages and disadvantages are discussed, as well as their usefulness for a range of library types

  8. Dihedral-Based Segment Identification and Classification of Biopolymers II: Polynucleotides

    Science.gov (United States)

    2013-01-01

    In an accompanying paper (Nagy, G.; Oostenbrink, C. Dihedral-based segment identification and classification of biopolymers I: Proteins. J. Chem. Inf. Model. 2013, DOI: 10.1021/ci400541d), we introduce a new algorithm for structure classification of biopolymeric structures based on main-chain dihedral angles. The DISICL algorithm (short for DIhedral-based Segment Identification and CLassification) classifies segments of structures containing two central residues. Here, we introduce the DISICL library for polynucleotides, which is based on the dihedral angles ε, ζ, and χ for the two central residues of a three-nucleotide segment of a single strand. Seventeen distinct structural classes are defined for nucleotide structures, some of which—to our knowledge—were not described previously in other structure classification algorithms. In particular, DISICL also classifies noncanonical single-stranded structural elements. DISICL is applied to databases of DNA and RNA structures containing 80,000 and 180,000 segments, respectively. The classifications according to DISICL are compared to those of another popular classification scheme in terms of the amount of classified nucleotides, average occurrence and length of structural elements, and pairwise matches of the classifications. While the detailed classification of DISICL adds sensitivity to a structure analysis, it can be readily reduced to eight simplified classes providing a more general overview of the secondary structure in polynucleotides. PMID:24364355

  9. Bismuth oxide based ceramics with improved electrical and mechanical properties: Part II. Structural and mechanical properties

    NARCIS (Netherlands)

    Kruidhof, H.; Seshan, K.; Velde, van de G.M.H.; Vries, de K.J.; Burggraaf, A.J.

    1988-01-01

    Coprecipitation as a method of preparation for bismuth oxides based ceramics yields relatively strong and machineable materials in comparison with the solid state reaction. Compositions within the system (1−x)Bi2O3|xEr2O3 containing up to twenty five mole percent of erbium oxide show a slow transiti

  10. Specific Affinity Enrichment of Electrochemically Cleaved Peptides Based on Cu(II)-Mediated Spirolactone Tagging

    NARCIS (Netherlands)

    Zhang, Tao; de Vries, Marcel P.; Permentier, Hjalmar P.; Bischoff, Rainer

    2017-01-01

    Specific digestion of proteins is an essential step for mass spectrometry-based proteomics, and the chemical labeling of the resulting peptides is often used for peptide enrichment or the introduction of desirable tags. Electrochemical oxidation yielding specific cleavage C-terminal to tyrosine

  11. Structure and activity relationships for amine based CO2 absorbents—II

    NARCIS (Netherlands)

    Singh, Prachi; Niederer, John P.M.; Versteeg, Geert F.

    2009-01-01

    A study to determine the structure and activity relationships of various amine-based CO2 absorbents was performed, in which the absorption of pure CO2 at atmospheric pressure was measured to assess the total absorption rates and capacities. Steric hindrance effect was noticed when side chain with al

  12. Structure and activity relationships for amine-based CO2 absorbents-II

    NARCIS (Netherlands)

    Niederer, J. P. M.; Versteeg, G. F.

    2009-01-01

    A study to determine the structure and activity relationships of various amine-based CO2 absorbents was performed, in which the absorption of pure CO2 at atmospheric pressure was measured to assess the total absorption rates and capacities. Steric hindrance effect was noticed when side chain with al

  13. Evidence-based treatment of stuttering: II. Clinical significance of behavioral stuttering treatments.

    Science.gov (United States)

    Finn, Patrick

    2003-01-01

    An evidence-based framework can be described as an empirically-driven, measurement-based, client-sensitive approach for selecting treatments. It is believed that using such a framework is more likely to result in a clinically significant outcome. For this paper, a clinically significant outcome was defined as a meaningful treatment change. It was suggested that there are at least three groups for whom a treatment's outcome is meaningful. These groups include clinicians/clinical researchers, the clients, and relevant others who have some interest in the outcome (e.g., parents of a child who stutters). The meaning and measurement of clinical significance was discussed for each of these three groups, based on research from the behavioral stuttering treatment literature. The reader will learn about and be able to (1) broadly define a clinically significant outcome and identify some of the groups who are interested in such an outcome and (2) describe how clinical significance has been evaluated in stuttering treatment within an evidence-based framework.

  14. High-performance aqueous asymmetric electrochemical capacitor based on graphene oxide/cobalt(II)-tetrapyrazinoporphyrazine hybrids

    CSIR Research Space (South Africa)

    Lekitima, JN

    2013-01-01

    Full Text Available equivalent series resistance clearly indicate that this new material has great potential for the development of low-cost and ‘green’ aqueous AECs that operate at high energy and power densities. Interestingly, the energy density of the GO/CoTPyzPz//GOCB based...

  15. Workshop on Consistency Problems in UML-based Software Development II

    OpenAIRE

    Kuzniarz, Ludwik; Huzar, Zbigniew; Reggio, Gianna; Sourrouille, Jean Louis; Staron, Miroslaw

    2003-01-01

    Workshop materials of the Second Workshop on Consistency Problems in UML-based Software Development. The workshop is part of the Sixth International Conference on The Unified Modeling Language <> 2003 Workshop Website http://www.ipd.bth.se/consistencyUML/uml2003Workshop.asp

  16. Improving students’ understanding of quantum measurement. II. Development of research-based learning tools

    Directory of Open Access Journals (Sweden)

    Guangtian Zhu1,2

    2012-04-01

    Full Text Available We describe the development and implementation of research-based learning tools such as the Quantum Interactive Learning Tutorials and peer-instruction tools to reduce students’ common difficulties with issues related to measurement in quantum mechanics. A preliminary evaluation shows that these learning tools are effective in improving students’ understanding of concepts related to quantum measurement.

  17. SOLVENT-BASED TO WATERBASED ADHESIVE-COATED SUBSTRATE RETROFIT - VOLUME II: PROCESS OVERVIEW

    Science.gov (United States)

    This volume presents initial results of a study to identify the issues and barriers associated with retrofitting existing solvent-based equipment to accept waterbased adhesives as part of an EPA effort to improve equipment cleaning in the coated and laminated substrate manufactur...

  18. A polyoxometalate-based single-molecule magnet with a mixed-valent {Mn(IV)2Mn(III)6Mn(II)4} core.

    Science.gov (United States)

    Zhang, Zhi-Ming; Yao, Shuang; Li, Yang-Guang; Wu, Hai-Hong; Wang, Yong-Hui; Rouzières, Mathieu; Clérac, Rodolphe; Su, Zhong-Min; Wang, En-Bo

    2013-03-28

    A polyoxometalate (POM)-based {Mn(IV)2Mn(III)6Mn(II)4} complex with single-molecule magnet (SMM) behaviour was prepared, exhibiting the largest known Mn nuclearity and the most Mn valence states in the POM-based SMM family.

  19. Syntheses, structures and luminescence behaviour of some zinc(II) complexes containing acetate and tetradentate Schiff bases

    Indian Academy of Sciences (India)

    Ashis Kumar Maji; Subhasis Roy; Somnath Choubey; Rajarshi Ghosh; Barindra Kumar Ghosh

    2015-05-01

    Two mononuclear compounds of the types pentacoordinated [Zn(L1)(OAc)]PF6·H2O (1) and hexacoordinated [Zn(L2)(OAc)]PF6 (2) [L1 = N,N′-(bis(pyridin-2-yl)formylidene)-1,3-propanediamine; L2 = N,N′-(bis(pyridin-2-yl)benzylidene)-1,4-butanediamine] have been synthesized using one-pot reactions of a 1:1:1 molar ratio of Zn(OAc)2.2H2O, L1/L2, ammonium hexafluorophosphate in MeOH at room temperature. Compounds 1 and 2 are characterized on the basis of microanalytical, spectroscopic, thermal and other physicochemical results. Single crystal X-ray structural study reveals that the zinc(II) centre in 1 is coordinated by four N atoms of the Schiff base L1 and one O atom of terminal acetate with a ZnN4O chromophore, whereas in 2, the zinc(II) centre is bound by four N atoms of the tailored Schiff base L2 and two O atoms of the chelated acetate. In the crystalline state, mononuclear units in 1 are engaged in weak cooperative intermolecular O-H⋯O and C-H⋯F hydrogen bonds affording a 1D chain. The individual units of 2 are packed by ⋯ and anion⋯ interactions to form a 2D sheet structure. The complexes show reasonable thermal stabilities and display intraligand → ∗ fluorescence in solid state at room temperature.

  20. Implementation of SPI Interface Based on Nios II%基于Nios II的SPI接口实现

    Institute of Scientific and Technical Information of China (English)

    康宾; 孙亮; 周玉娟

    2014-01-01

    The Nios II is the second generation of FPGA embedded processor of Altera company and links with the peripheral interface to construct a complete SOPC system. AD9517-1ABCPZ is a clock chip, which is configured through SPI interface to operate prior to other parts of system and provide the clock for other chips of system. The implementation of SPI interface can use many methods, and the one adopted in this paper is based on Nios II. This method has the advantages such as simple and flexible operation, short development cycle, low cost as well as easy maintenance systems, etc., which can be applied to various intermediate-speed and low-speed system design. The implementation method mainly includes hardware and software design, the hardware design includes the construction of SOPC system based on Nios II and the design of SPI-MASTER interface FPGA program;the software design includes the design of SPI read-write functions and the design of AD9517-1ABCPZ register configuration functions.%Nios II是Altera公司的第二代FPGA嵌入式处理器,和其挂接的外围接口相当于一个完整的SOPC系统, AD9517-1ABCPZ是一款时钟芯片,需通过SPI接口配置,让其先于系统的其他部分工作,为系统其它芯片提供时钟。针对SPI接口的实现,目前有很多方法,基于Nios II实现,具有简单灵活、开发周期短、成本低和系统维护方便等优点,可应用于许多中、低速系统设计。实现主要包括硬件设计和软件设计,硬件设计包括基于Nios II的SOPC系统的搭建,SPI-MASTER接口FPGA程序设计;软件设计包括SPI读写函数设计,AD9517-1ABCPZ寄存器配置函数设计。