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Sample records for kable heather russell

  1. A Ka-band (32 GHz) beacon link experiment (KABLE) with Mars Observer

    Science.gov (United States)

    Riley, A. L.; Hansen, D. M.; Mileant, A.; Hartop, R. W.

    1987-02-01

    A proposal for a Ka-Band (32 GHz) Link Experiment (KABLE) with the Mars Observer mission was submitted to NASA. The experiment will rely on the fourth harmonic of the spacecraft X-band transmitter to generate a 33.6 GHz signal. The experiment will rely also on the Deep Space Network (DSN) receiving station equipped to simultaneously receive X- and Ka-band signals. The experiment will accurately measure the spacecraft-to-Earth telecommunication link performance at Ka-band and X-band (8.4 GHz).

  2. Fungi causing dying out of heather seedlings

    Directory of Open Access Journals (Sweden)

    Maria Kowalik

    2012-12-01

    Full Text Available The aim of the study was to determine the fungi causing dying out of one-yearold heather seedlings. Observations were carried out on: 'Amethyst', 'Annemarie', 'Colette', 'Perestroika' and 'Reini'. The shoots revealing necrotic symptoms were plated on PDA medium. 25 species of fungi were isolated. Among them Pestalotia sydowiana, Alternaria alternata, Cylindrocarpon destructans, Leptosphaeria coniothyrium and Epicoccum purpurascens were dominant, while Mammaria echinobotryoides, Phoma leveillei, Kaissleriella subalpina, Botrytis cinerea and Phytophthora cinnamomi occurred less frequently.

  3. Fungi causing dying out of heather seedlings

    OpenAIRE

    Maria Kowalik; Agnieszka Wandzel

    2012-01-01

    The aim of the study was to determine the fungi causing dying out of one-yearold heather seedlings. Observations were carried out on: 'Amethyst', 'Annemarie', 'Colette', 'Perestroika' and 'Reini'. The shoots revealing necrotic symptoms were plated on PDA medium. 25 species of fungi were isolated. Among them Pestalotia sydowiana, Alternaria alternata, Cylindrocarpon destructans, Leptosphaeria coniothyrium and Epicoccum purpurascens were dominant, while Mammaria echinobotryoides, Phoma leveille...

  4. Some Tests on Heather Field Moraine Clay

    DEFF Research Database (Denmark)

    Jørgensen, Mogens B.; Jacobsen, Moust

    This report deals with oedometer tests on three samples of moraine clay from the Heather Field in the English part of the North Sea. The tests have been carried out in the very unelastic apparatus used in Denmark and with special test procedures differing from the ones used elsewhere. In Denmark...... the English North Sea moraine clays with the corresponding Danish Moraine Clays. The Danish test procedures are explained in details and some comments are given in the hope that they may not be banalities all of them....

  5. Russell Dunes

    Science.gov (United States)

    2004-01-01

    26 March 2004 Dark streaks made by dozens of spring and summer dust devils created a form of martian graffiti on the sand dunes of Russell Crater near 54.5oS, 347.4oW. Gullies have developed on some of the dune slopes, as well. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image covers an area about 3 km (1.9 mi) across. Sunlight illuminates the scene from the upper left.

  6. Russell Extravaganza

    Science.gov (United States)

    2006-01-01

    26 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows dark-toned sand dunes on the floor of Russell Crater in south-central, Noachis Terra. A dune at the right (east) edge of the image is host to several small gullies whose channels extend predominantly to the west-southwest. The formation of these features is not well-understood, but they might result from a combination of downslope movement of sand and a lubricating agent, perhaps carbon dioxide gas or water that had been trapped in the dune as ice. The randomly-oriented dark streaks seen on the dunes and on the interdune surfaces were created by the passage of spring and summertime dust devils. Location near: 54.7oS, 347.4oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

  7. Heather Gell and Music Education in the Community

    Science.gov (United States)

    Nash, Sandra

    2014-01-01

    Kindergartener and Dalcroze teacher, Heather Gell (1896-1988), brought music to thousands of Australian children and adults. The community touched by Gell was vast: it included her classes in studios and teacher training colleges, "listeners in" to her radio programs, viewers of her television programs, Dalcroze trainees, and people in…

  8. Russell on Memory

    Directory of Open Access Journals (Sweden)

    Thomas Baldwin

    2001-12-01

    Full Text Available Russell famously propounded scepticism about memory in The Analysis of Mind (1921. As he there acknowledged, one way to counter this sceptical position is to hold that memory involves direct acquaintance with past, and this is in fact a thesis Russell had advanced in The Problems of Philosophy (1911. Indeed he had there used the case of memory to develop a sophisticated falibilist, non-sceptical, epistemology. By 1921, however, Russell had rejected the early conception of memory as incompatible with the neutral monism he now affirmed. In its place he argued that memory involves a distinctive type of belief whose content is given by imagery. Russell's language here is off-putting but without much distortion his later position can be interpreted as an early formulation of a functionalist theory of mind based on a causal theory of mental representation. Thus interpreted it provides the basis for a different response to Russell's sceptical thesis.

  9. Russell-Silver syndrome

    Science.gov (United States)

    ... other conditions that may mimic Russell-Silver syndrome) Treatment Growth hormone replacement may help if this hormone is lacking. Other treatments include: Making sure the person gets enough calories, ...

  10. {sup 134}Cs in heather seed plants grown with and without mycorrhiza

    Energy Technology Data Exchange (ETDEWEB)

    Strandberg, M. [Risoe National Laboratory, DK-4000 Roskilde (Denmark); Johansson, M. [Department of Mycology, Botanical Institute, University of Copenhagen, Oester Farimagsgade 2D, DK-1353 Copenhagen K. (Denmark)

    1988-08-01

    Experiments were carried out to determine differences between mycorrhized and non-mycorrhized seed plants of heather, Calluna vulgaris(L)Hull, as regards the uptake of {sup 134}Cs. In most treatments heather with mycorrhiza had a significantly higher transfer of {sup 134}Cs to the shoots than heather without mycorrhiza. As an average the concentration of {sup 134}Cs was 18% higher in the mycorrhized plants than in the non-mycorrhized. Application of 10 kg K/ha reduced the concentration of {sup 134}Cs in shoots of heather by 49% as an average. Because of improved growth in the potassium fertilized pots the reduction viewed on the basis of the area was only 33%. Nitrogen application does not significantly influence the concentration of {sup 134}Cs in shoots of heather regardless of mycorrhizal status. (Copyright (c) 1988 Elsevier Science B.V., Amsterdam. All rights reserved.)

  11. Russell and Humean Inferences

    Directory of Open Access Journals (Sweden)

    João Paulo Monteiro

    2001-12-01

    Full Text Available Russell's The Problems of Philosophy tries to establish a new theory of induction, at the same time that Hume is there accused of an irrational/ scepticism about induction". But a careful analysis of the theory of knowledge explicitly acknowledged by Hume reveals that, contrary to the standard interpretation in the XXth century, possibly influenced by Russell, Hume deals exclusively with causal inference (which he never classifies as "causal induction", although now we are entitled to do so, never with inductive inference in general, mainly generalizations about sensible qualities of objects ( whether, e.g., "all crows are black" or not is not among Hume's concerns. Russell's theories are thus only false alternatives to Hume's, in (1912 or in his (1948.

  12. Bertrand Russell on Chinese Education

    Science.gov (United States)

    Zheng, Wei-ping

    2008-01-01

    The visit of Bertrand Russell to China during 1920 to 1921 was one of the most significant events in May Fourth Movement, and Russell pointed out that education was the most important thing for Chinese reconstruction. The author argues that we should interpret Russell's educational idea of China from a theoretic and practical point of view. The…

  13. XS-1 Jack Russell

    Science.gov (United States)

    1956-01-01

    NACA High-Speed Flight Station Rocket Shop. Jack Russell, Head of the Rocket Shop preparing to do pressurization tests on the XLR-11 rocket engine. The console provided the readings for the test of the rocket engine systems. 1956 photo

  14. XS-1 Jack Russell

    Science.gov (United States)

    1956-01-01

    NACA High-Speed Flight Station Rocket Shop. Jack Russell, Head of the Rocket Shop preparing to do pressurization tests on the XLR-11 rocket engine. The console provided the readings for the test of the rocket engine systems. 1956 photo

  15. Russel-Silver syndrome

    OpenAIRE

    Nogueiras, AM; Costeiras, MT; Moreira, HS; Antunes, AH

    2001-01-01

    Russel-Silver syndrome is a pattern of malformations whose most characteristic features are intrauterine and postnatal growth retardation, a characteristic facial appearance and limb asymmetry. We report a 9-month-old male born at 37 weeks' gestation. Family history, pregnancy and delivery revealed no significant anomalies. The infant had no intrauterine growth retardation (birth weight and height ranging between the 25 th and 50 th percentile). The infant's head circumference was disproporti...

  16. Russell Dune Gullies

    Science.gov (United States)

    2005-01-01

    5 November 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows gullies and dust devil streaks on the slopes of a large dune in Russell Crater. Gullies on martian dunes typically occur only in the Noachis Terra region, and almost exclusively form on southward-facing slopes. They might be the result of downslope movement of sand mixed with a fluid such as carbon dioxide gas or water that had been trapped as ice in the dune. Location near: 54.6oS, 347.2oW Image width: width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Spring

  17. An Interview with Lesléa Newman: A Punchy New Heather, Dolly Parton, and Orange is the New Black.

    Science.gov (United States)

    Peel, Katie R

    2015-01-01

    This interview with Lesléa Newman took place on Monday, September 22, 2014. Newman, while quite prolific, is probably best known for her children's picture book, Heather Has Two Mommies, initially published in 1989. Heather became the cultural touchstone in discussions of not only lesbianism and children's literature, but book challenges and censorship, as well. In this interview, Newman speaks about the evolution of Heather and her various editions, new frontiers in both children's literature and representations of lesbians, identity politics and authorship, transgender issues and children's literature, and the continued need for diversity in literature for young readers.

  18. Effect of the consumption of heather on incoming larvae and established population of Teladorsagia circumcincta in experimentally infected Cashmere goats.

    Science.gov (United States)

    Moreno-Gonzalo, J; Osoro, K; García, U; Frutos, P; Celaya, R; Ferreira, L M M; Ortega-Mora, L M; Ferre, I

    2013-09-01

    This study was performed in Cashmere goats that were experimentally infected with Teladorsagia circumcincta to investigate the effects of heather consumption on the establishment of incoming infective larvae (experiment 1) and on an adult nematode population (experiment 2). In experiment 1, 24 non-lactating goats were divided into 2 groups: heather-supplemented vs. non-supplemented. After 2 weeks of adaptation to the diet, all of the goats were experimentally infected with 6000 infective larvae of T. circumcincta. Twelve animals (6 controls and 6 supplemented with heather) were slaughtered at 6 days and at 3 weeks post-infection (pi). After slaughter, the worms were counted and the female worm fecundity and development were determined. Heather consumption was associated with a significant reduction in larval establishment at 6 days (P=0.033) and at 3 weeks (P=0.041) pi. No differences in worm counts between the slaughter times were found. In the goats slaughtered at 3 weeks pi, the number of eggs in utero and length of the female worms were significantly (Pgoats were experimentally infected with 10,000 T. circumcincta infective larvae daily for 5 consecutive days (total infection of 50,000 larvae). After 3 weeks, 2 groups were established: control and heather-supplemented. The faecal egg output of each animal was measured at 2-days interval during the experimental period. The goats were slaughtered after 3 weeks of heather administration for parasitological studies. Heather administration was associated with a significant decrease in egg excretion between 25 and 29 days pi. The worm counts were similar in both groups, but the female length and fecundity were significantly (Pgoats. These results show that heather consumption reduces the establishment of T. circumcincta larvae in goats and the development and fecundity of female adult parasites. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Heather Clark. The Ulster Renaissance - Poetry in Belfast 1962-1972

    Directory of Open Access Journals (Sweden)

    Maryvonne BOISSEAU

    2007-06-01

    Full Text Available The idea of what has been termed an Ulster Renaissance to refer to the surge of new poetry in the North of Ireland in the late 1960s and 1970s together with what is known as the Belfast Group is often dismissed by the poets themselves and serious critics as a mere shorthand and inaccurate way to describe the vitality of that decade. Heather Clark’s study, originally a PhD dissertation, challenges this and argues for the significant impact of Hobsbaum’s group, later Heaney’s group, as well as ...

  20. Russell body duodenitis with immunoglobulin kappa lightchain restriction

    Institute of Scientific and Technical Information of China (English)

    William R Munday; Lucy Harn Kapur; Mina Xu; Xuchen Zhang

    2015-01-01

    Russell bodies are eosinophilic intracytoplasmicglobules which are likely the result of disturbedsecretion of immunoglobulins that accumulate withinthe plasma cell. Russell body collections have beenidentified within the stomach, known as Russellbody gastritis. Similar lesions within the duodenumare referred to as Russell body duodenitis, whichis rare. Several Russell body gastritis case reportsare associated with Helicobacter pylori . However,the etiology of Russell body duodenitis remainsunclear. Here we report the first case of Russell bodyduodenitis with immunoglobulin light chain restrictionin a background of peptic duodenitis.

  1. Genetics Home Reference: Russell-Silver syndrome

    Science.gov (United States)

    ... compared to the rest of the body. Affected children are thin and have poor appetites, and some develop recurrent episodes of low blood sugar (hypoglycemia) as a result of feeding difficulties. Adults with Russell-Silver ... with Russell-Silver syndrome have a small, triangular ...

  2. William Russell on Schools in Bulgaria

    Science.gov (United States)

    Popov, Nikolay; Sabic-El-Rayess, Amra

    2013-01-01

    William Russell became one of the most influential educators in the field of international and comparative education in the first half of the 20th century. In 1914, William Russell obtained his PhD from Teachers College and, within few years, became a prominent figure internationally. He traveled through Europe and taught in Japan and Siberia, as…

  3. Chernobyl-derived radiocesium in heather honey and its dependence on deposition patterns.

    Science.gov (United States)

    Fisk, S; Sanderson, D C

    1999-10-01

    Gamma-ray spectra were measured from Scottish heather honey samples gathered from hive locations with associated airborne gamma-ray survey data. The honeys all contained radiocesium, with activity concentrations ranging from 43-680 Bq kg(-1) 137Cs, and 134Cs/137Cs ratios consistent with Chernobyl deposition. Activity concentrations in honey were highly correlated with ground deposition within 2.5 km of the hive location over two successive years. Both isotope ratios and the quantitative relationships between environmental and food levels suggest that weapons testing fallout is significantly less available than recent deposition. The implications for design of future monitoring programs and radiological consequences are discussed. The whole-body retention of 137Cs in honey ingested by a volunteer was consistent with the ICRP's metabolic model for cesium.

  4. Biochemical nature of Russell Bodies.

    Science.gov (United States)

    Mossuto, Maria Francesca; Ami, Diletta; Anelli, Tiziana; Fagioli, Claudio; Doglia, Silvia Maria; Sitia, Roberto

    2015-07-30

    Professional secretory cells produce and release abundant proteins. Particularly in case of mutations and/or insufficient chaperoning, these can aggregate and become toxic within or amongst cells. Immunoglobulins (Ig) are no exception. In the extracellular space, certain Ig-L chains form fibrils causing systemic amyloidosis. On the other hand, Ig variants lacking the first constant domain condense in dilated cisternae of the early secretory compartment, called Russell Bodies (RB), frequently observed in plasma cell dyscrasias, autoimmune diseases and chronic infections. RB biogenesis can be recapitulated in lymphoid and non-lymphoid cells by expressing mutant Ig-μ, providing powerful models to investigate the pathophysiology of endoplasmic reticulum storage disorders. Here we analyze the aggregation propensity and the biochemical features of the intra- and extra-cellular Ig deposits in human cells, revealing β-aggregated features for RB.

  5. Russell body duodenitis with immunoglobulin kappa light chain restriction.

    Science.gov (United States)

    Munday, William R; Kapur, Lucy Harn; Xu, Mina; Zhang, Xuchen

    2015-01-16

    Russell bodies are eosinophilic intracytoplasmic globules which are likely the result of disturbed secretion of immunoglobulins that accumulate within the plasma cell. Russell body collections have been identified within the stomach, known as Russell body gastritis. Similar lesions within the duodenum are referred to as Russell body duodenitis, which is rare. Several Russell body gastritis case reports are associated with Helicobacter pylori. However, the etiology of Russell body duodenitis remains unclear. Here we report the first case of Russell body duodenitis with immunoglobulin light chain restriction in a background of peptic duodenitis.

  6. Clinical spectrum of silver - Russell syndrome

    Directory of Open Access Journals (Sweden)

    Sapna N.K. Varma

    2013-01-01

    Full Text Available Silver - Russell syndrome is a clinically and genetically heterogenous condition characterized by severe intrauterine and postnatal growth retardation, craniofacial disproportion and normal intelligence downward curvature of the corner of the mouth, syndactyly and webbed fingers. Diagnosis of Silver - Russell syndrome remains clinical; no definite etiology or specific tests have been established. In the recent years, it has been shown that more than 38% of patients have hypomethylation in the imprinting control region 1 of 11p15 and one-tenth of patients carry a maternal uniparental disomy of chromosome seven. The pathophysiological mechanisms resulting in the Silver - Russell phenotype remain unknown despite the recent progress in deciphering the molecular defects associated with this condition. This case report describes the clinical features of Silver - Russell syndrome in a father and daughter.

  7. Defrosting of Russell Crater Dunes

    Science.gov (United States)

    2007-01-01

    These two images (at right) were acquired by the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) 39 days apart at 19:10 UTC (2:10 PM EST) on December 28, 2006 (upper right) and at 20:06 UTC (3:06 PM EST) on February 5, 2007 (lower right). These CRISM data were acquired in 544 colors covering the wavelength range from 0.36-3.92 micrometers, and show features as small as 20 meters (about 65 feet) across. Both images are false color composites of bands at 2.5, 1.5, and 1.25 micrometers, and are nearly centered at the same location, 54.875oS, 12.919oE (upper right) and 54.895oS, 12.943oE (lower right). Each image is approximately 11 kilometers (7 miles) across at its narrowest. These are part of a series of images capturing the evolution of carbon dioxide frost on the surface of the dunes in Russell Crater. Russell Crater is one of many craters in the southern highland region of Mars that contain large areas of sand dunes. The sand in these dunes has accumulated over a very long time period -- perhaps millions of years -- as wind blows over the highland terrain, picking up sand in some places and depositing in others. The topography of the craters forces the wind to blow up and over the crater rims, and the wind often isn't strong enough to keep the tiny grains suspended. This makes the sand fall to the ground and gradually pile up, and over time the surface breezes shape the sand into ripples and dunes. A similar process is at work at the Great Sand Dunes National Park and Preserve in Colorado, USA. The above left image shows a THEMIS daytime infrared mosaic of Russell Crater and the location of its (approximately) 30-kilometer wide dune field in the northeastern quadrant of the crater floor. Superposed on this view and shown enlarged at the upper right is CRISM image FRT000039DF. This CRISM image was acquired during the late Martian southern winter (solar longitude = 157.7o), and the bright blue in this false color composite indicates the presence of

  8. Alfred Russel Wallace deserves better

    Indian Academy of Sciences (India)

    David Lloyd; Julian Wimpenny; Alfred Venables

    2010-09-01

    During 2009, while we were celebrating Charles Darwin and his The origin of species, sadly, little was said about the critical contribution of Alfred Russel Wallace (1823–1913) to the development of the theory of evolution. Like Darwin, he was a truly remarkable nineteenth century intellect and polymath and, according to a recent book by Roy Davies (The Darwin conspiracy: origins of a scientific crime), he has a stronger claim to the Theory of Evolution by Natural Selection than has Darwin. Here we present a critical comparison between the contributions of the two scientists. Sometimes referred to as ‘The other beetle-hunter’ and largely neglected for many decades, Wallace had a far greater experience of collecting and investigating animals and plants from their native habitats than had Darwin. He was furthermore much more than a pioneer biogeographer and evolutionary theorist, and also made contributions to anthropology, ethnography, geology, land reform and social issues. However, being a more modest, self-deprecating man than Darwin, and lacking the latter’s establishment connections, Wallace’s contribution to the theory of evolution was not given the recognition it deserved and he was undoubtedly shabbily treated at the time. It is time that Wallace’s relationship with Darwin is reconsidered in preparation for 2013, the centenary of Wallace’s death, and he should be recognized as at least an equal in the Wallace–Darwin theory of evolution.

  9. Silver-Russell syndrome in Hong Kong.

    Science.gov (United States)

    Luk, H M; Yeung, K S; Wong, W L; Chung, B Hy; Tong, T Mf; Lo, I Fm

    2016-12-01

    To examine the molecular pathogenetic mechanisms, (epi)genotype-phenotype correlation, and the performance of the three clinical scoring systems-namely Netchine et al, Bartholdi et al, and Birmingham scores-for patients with Silver-Russell syndrome in Hong Kong. This retrospective case series was conducted at two tertiary genetic clinics, the Clinical Genetic Service, Department of Health, and clinical genetic clinic in Queen Mary Hospital in Hong Kong. All records of patients with suspected Silver-Russell syndrome under the care of the two genetic clinics between January 2010 and September 2015 were retrieved from the computer database. Of the 28 live-birth patients with Silver-Russell syndrome, 35.7% had H19 loss of DNA methylation, 21.4% had maternal uniparental disomy of chromosome 7, 3.6% had mosaic maternal uniparental disomy of chromosome 11, and the remaining 39.3% were Silver-Russell syndrome of unexplained molecular origin. No significant correlation between (epi)genotype and phenotype could be identified between H19 loss of DNA methylation and maternal uniparental disomy of chromosome 7. Comparison of molecularly confirmed patients and patients with Silver-Russell syndrome of unexplained origin revealed that postnatal microcephaly and café-au-lait spots were more common in the latter group, and body and limb asymmetry was more common in the former group. Performance analysis showed the Netchine et al and Birmingham scoring systems had similar sensitivity in identifying Hong Kong Chinese subjects with Silver-Russell syndrome. This is the first territory-wide study of Silver-Russell syndrome in Hong Kong. The clinical features and the spectrum of underlying epigenetic defects were comparable to those reported in western populations.

  10. Hertzsprung and Russell: The Minards of Astronomy

    Science.gov (United States)

    Broek, J. V. D.; Russo, P.

    2014-01-01

    This article will explore the history of flow maps, the extent of their use and how astronomy has benefited from this illustrative way of communicating ideas. Flow maps are multidimensional infographics that tell a long story in one single image. In 1812 the French civil engineer Charles Joseph Minard created a flow map that is still dubbed "the mother of all flow maps", summarising Napoleon's Russian campaign (Figure 1). Almost 100 years later, in 1910, Ejnar Hertzsprung and Henry Norris Russell created a multidimensional flow map that arguably surpasses Minard's map in ingenuity -- the Hertzprung-Russell diagram. The Hertzprung-Russell diagram represents a major step towards an understanding of stellar evolution, or "the lives of stars", and is still used in astronomy today.

  11. City of Russell, Kansas - Clean Water Act Public Notice

    Science.gov (United States)

    The EPA is providing notice of a proposed Administrative Penalty Assessment against the City of Russell, KS, a municipality located at 133 West 8th Street, Russell, KS for alleged violations of its National Pollutant Discharge Elimination System permit (pe

  12. 21 CFR 864.8950 - Russell viper venom reagent.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Russell viper venom reagent. 864.8950 Section 864...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Reagents § 864.8950 Russell viper venom reagent. (a) Identification. Russell viper venom reagent is a device used to determine the cause of an...

  13. The spectroscopic Hertzsprung-Russell diagram

    CERN Document Server

    Langer, N

    2014-01-01

    The Hertzsprung-Russell diagram is an essential diagnostic diagram for stellar structure and evolution, which has now been in use for more than 100 years. Our spectroscopic Hertzsprung-Russell (sHR) diagram shows the inverse of the flux-mean gravity versus the effective temperature. Observed stars whose spectra have been quantitatively analyzed can be entered in this diagram without the knowledge of the stellar distance or absolute brightness. Observed stars can be as conveniently compared to stellar evolution calculations in the sHR diagram as in the Hertzsprung-Russell diagram. However, at the same time, our ordinate is proportional to the stellar mass-to-luminosity ratio, which can thus be directly determined. For intermediate- and low-mass star evolution at constant mass, we show that the shape of an evolutionary track in the sHR diagram is identical to that in the Hertzsprung-Russell diagram. We also demonstrate that for hot stars, their stellar Eddington factor can be directly read off the sHR diagram. ...

  14. Bertrand Russell Speaks: The BBC Interviews.

    Science.gov (United States)

    Wyatt, Woodrow

    1982-01-01

    Presents excerpts from 13 interviews with Bertrand Russell conducted for British television in 1959. The discussion covers the nature and purpose of philosophy, religion, war and pacifism, communism and capitalism, ethics and morality, personal and economic power, happiness, nationalism, individualism, fanaticism, and tolerance. (AM)

  15. Russel Nye: The Professor in Public Life.

    Science.gov (United States)

    Hungiville, Maurice

    1995-01-01

    A discussion of the influence of Russel Nye, a college English professor at Michigan State University and journalist, focuses on the values that shaped his teaching, scholarship, and writing and his defense of democratic values, especially in education. It is concluded that Nye's experience suggests that public service can be a source of personal…

  16. Astronaut Russell Schweickart photographed during EVA

    Science.gov (United States)

    1969-01-01

    Astronaut Russell L. Schweickart, lunar module pilot, is photographed from the Command Module 'Gumdrop' during his extravehicular activity on the fourth day of the Apollo 9 earth-orbital mission. The Command and Service Modules are docked with the Lunar Module.

  17. Heather K. Gerken, The Democracy Index: Why Our Election System is Failing and How to Fix It.

    OpenAIRE

    2010-01-01

    How can anyone who followed the 2000 Bush-Gore presidential election forget the fiasco that ensued in the state of Florida?  The discrepancies, allegations, and ultimately, the necessity of a recount, marred America’s claim of having a well-oiled electoral system and smooth functioning democracy.  In part, this book by Heather K. Gerken is a response to the national and international embarrassment emerging from that election.  But as the author reveals, the 2000 presidential election merely r...

  18. Heather K. Gerken, The Democracy Index: Why Our Election System is Failing and How to Fix It.

    Directory of Open Access Journals (Sweden)

    Joseph Michael Gratale

    2010-07-01

    Full Text Available How can anyone who followed the 2000 Bush-Gore presidential election forget the fiasco that ensued in the state of Florida?  The discrepancies, allegations, and ultimately, the necessity of a recount, marred America’s claim of having a well-oiled electoral system and smooth functioning democracy.  In part, this book by Heather K. Gerken is a response to the national and international embarrassment emerging from that election.  But as the author reveals, the 2000 presidential election merely r...

  19. Henry Norris Russell and the Expanding Universe

    CERN Document Server

    DeVorkin, David H

    2013-01-01

    Henry Norris Russell, one of the most influential American astronomers of the first half of the 20th Century, had a special place in his heart for the Lowell Observatory. Although privately critical of the founder for his pronouncements about life on Mars and the superiority of the Mars Hill observing site, he always supported the Observatory in public and professional circles. He staunchly supported Tombaugh's detection of a planet as leading from Lowell's prediction, and always promoted V. M. Slipher's spectroscopic investigations of planetary and stellar phenomena. But how did he react to Slipher's puzzling detection of the extreme radial velocities of spiral nebulae starting in 1912, and how did he regard the extension and interpretation of those observations by Hubble and others in following decades? Here we describe the arc of Russell's reactions, dating from Slipher's first detection, as an indicator of how mainstream stellar astronomers reacted to the concept of an expanding universe.

  20. The Critical Importance of Russell's Diagram

    CERN Document Server

    Gingerich, Owen

    2013-01-01

    The idea of dwarf and giants stars, but not the nomenclature, was first established by Eijnar Hertzsprung in 1905; his first diagrams in support appeared in 1911. In 1913 Henry Norris Russell could demonstrate the effect far more strikingly because he measured the parallaxes of many stars at Cambridge, and could plot absolute magnitude against spectral type for many points. The general concept of dwarf and giant stars was essential in the galactic structure work of Harlow Shapley, Russell's first graduate student. In order to calibrate the period-luminosity relation of Cepheid variables, he was obliged to fall back on statistical parallax using only 11 Cepheids, a very sparse sample. Here the insight provided by the Russell diagram became critical. The presence of yellow K giant stars in globular clusters credentialed his calibration of the period-luminosity relation by showing that the calibrated luminosity of the Cepheids was comparable to the luminosity of the K giants. It is well known that in 1920 Shaple...

  1. The Doctrine of Relations in Bertrand Russell's Principles of Mathematics

    Directory of Open Access Journals (Sweden)

    Michael Pakaluk

    2013-11-01

    Full Text Available The question of the nature of relations is of great importance in the early writings of Bertrand Russell, since his disagreements with British Idealism center around relations, and his philosophy of mathematics depends crucially on relations. Yet there is no extended and systematic discussion of relations in early Russell. After examining Russell's definition of a relation, the author systematically and critically examines Russell's views in Principles of Mathematics on the following issues: whether a relation exists apart from its terms; the intensional character of relations; difficulties in reflexive relations; and whether simple relations can relate more than two relata.

  2. The legacy of nitrogen pollution in heather moorlands: ecosystem response to simulated decline in nitrogen deposition over seven years.

    Science.gov (United States)

    Edmondson, J; Terribile, E; Carroll, J A; Price, E A C; Caporn, S J M

    2013-02-01

    Eutrophication and acidification of heather moorlands by chronic atmospheric nitrogen (N) pollution, is of major concern within these internationally important ecosystems. However, in the UK and Western Europe generally emissions of NO(y) and NH(x) peaked during the 20th century. Due to the history and scale of atmospheric N pollution, the legacy of these high levels of N deposition, through accumulation in soil, may hinder or prevent ecosystem recovery. Effects of N pollution on heather moorland were investigated throughout the ecosystem including; the dominant plant species, Calluna vulgaris, the bryophyte and lichen community and the soil system using a long-term experiment simulating wet N deposition. We observed an increase in C. vulgaris height, shoot extension and canopy density, litter mineral N, total N concentration, N:P and C:N ratios in response to N addition. Bryophyte species diversity, bryophyte and lichen frequency and the frequency of two individual bryophyte species (Lophozia ventricosa and Campylopus flexuosus) were significantly reduced by N addition. We developed an N recovery experiment, using a split-plot design, on the long-term N treatment plots to investigate ecosystem response to a simulated decline in N deposition. Two years after cessation of N treatment the only ecosystem component that responded to the recovery experiment was C. vulgaris shoot extension, however after seven years of recovery there were significant declines in litter total N concentration and mineral N and an increase in litter C:N ratio. Although bryophytes and lichens form a close relationship with atmospheric N deposition these organisms did not show a significant response to the N recovery experiment, two years after cessation of N treatment. These data indicate that low nutrient ecosystems, such as moorlands, have the capacity to respond to declines in N deposition however the accumulation of pollution may hinder recovery of sensitive organisms, such as bryophytes

  3. Comment on Brent Beal's and Heather Olson Beal's "Rethinking the Market Metaphor: School Choice, the Common Good, and the National Football League"

    Science.gov (United States)

    Bast, Joseph L.

    2013-01-01

    In their article "Rethinking the Market Metaphor: School Choice, the Common Good, and the National Football League," Brent D. Beal and Heather K. Olson Beal (this issue) promise to update some of the arguments made by Jeffrey R. Henig (1994) and add an interesting twist by proposing the National Football League (NFL) as a possible…

  4. Comment on Brent Beal's and Heather Olson Beal's "Rethinking the Market Metaphor: School Choice, the Common Good, and the National Football League"

    Science.gov (United States)

    Bast, Joseph L.

    2013-01-01

    In their article "Rethinking the Market Metaphor: School Choice, the Common Good, and the National Football League," Brent D. Beal and Heather K. Olson Beal (this issue) promise to update some of the arguments made by Jeffrey R. Henig (1994) and add an interesting twist by proposing the National Football League (NFL) as a possible…

  5. 学习曲线 Russell Westbrook

    Institute of Scientific and Technical Information of China (English)

    Husky

    2009-01-01

    俄克拉荷马雷霆队能从1月份开始逐渐打得有模有样,摇身一变成为西区的危险刺客,主要是因为他们顺着学习曲线成长,开始收到一些成果,或者也可以说这是某个球员的进步帮助了团队,他就是新秀控卫韦斯特布鲁克(Russell Westbrook)。

  6. 36 CFR 7.68 - Russell Cave National Monument.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Russell Cave National Monument. 7.68 Section 7.68 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.68 Russell Cave National Monument. (a...

  7. 76 FR 39867 - Russell, John G.; Notice of Filing

    Science.gov (United States)

    2011-07-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Russell, John G.; Notice of Filing Take notice that on June 29, 2011, John G. Russell submitted for filing, an application for authority to hold interlocking positions, pursuant to...

  8. Formulation and application of Russell's method

    Science.gov (United States)

    Hou, J. W.

    1985-01-01

    It is shown that the numerical technique of Russell's momentum approach can be derived by using Hamilton's principle and Vance's numerical scheme. It results in a set of first order differnce equations for solving the angular velocities. The numerical examples show that the method is reliable. The algorithm is modified next to perform the analysis of N-body systems with closed loop topology. To increase the formulation flexibility, the equations of motion are represented by using Cartesian coordinates and Lagrange multipliers. The algorithm consists of two parts, Vance's scheme and an unconstrained minimization. The Vance's scheme is used to find the angular velocities, and the unconstrained minimization is applied to provide the correct angular displacements. The proposed scheme is further extended to find the design sensitivity of an N-body system with closed loop configuration, and to carry out the design optimization as well. The numerical example of a small-scaled mechanical system is presented to verify the proposed formulation.

  9. 76 FR 20388 - Russell Investment Company, et al.; Notice of Application

    Science.gov (United States)

    2011-04-12

    ... COMMISSION Russell Investment Company, et al.; Notice of Application April 6, 2011. AGENCY: Securities and... the Act to invest in certain financial instruments. Applicants: Russell Investment Company and Russell Investment Funds (each a ``Trust and collectively the ``Trusts), Russell Investment Management Company...

  10. Polycyclic aromatic hydrocarbons in smoke used to smoke cheese produced by the combustion of rock rose (Cistus monspeliensis) and tree heather (Erica arborea) wood.

    Science.gov (United States)

    Conde, Francisco J; Ayala, Juan H; Afonso, Ana M; González, Venerando

    2005-01-12

    In this work, the polycyclic aromatic hydrocarbons (PAHs) and their methyl derivatives concentrations have been determined in smoke from the rock rose and tree heather wood combustion. The combustion is done in two types of smokers, kiln and drum, commonly used in the Canary Islands (Spain) to smoke cheese. The low control of the operational conditions justify the great variability of the PAHs concentration in the emissions, with values between 251.8 and 2547 microg/m3N. In general, the lowest concentrations correspond to the tree heather wood combustion in the drum, while the highest concentrations are usually reached in the rock rose wood combustion in the kiln. However, the relative contributions of each PAH to the total concentration are independently similar to the type of smoker and wood used. In the combustion conditions, the equilibrium is not reached during the PAHs distribution process between the gas and aerosol phases. Therefore, while naphthalene and their 1- and 2-methyl derivatives remain in the gas phase, phenanthrene and PAHs with higher molecular weight remain mainly in the aerosol phase. In this phase, the PAHs concentration represents 39.9% of the total PAHs produced by burning rock rose wood and 29.1% of the total PAHs when tree heather wood is used. To establish the carcinogenic potential in both phases, the percentages of some PAHs were calculated. These values are significantly higher in the aerosol phase and, at the same time, higher when rock rose wood is used.

  11. Charles M. Russell National Wildlife Refuge fence mapping and inventory

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final report for a project at Charles M. Russell National Wildlife Refuge (CMR) to GIS map refuge pasture boundaries and applying historic domestic livestock use to...

  12. Charles M. Russell National Wildlife Refuge Wilderness proposal recommendations & analysis

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains information supporting and altering the proposal for designated wilderness located in the Charles M. Russell National Wildlife Refuge....

  13. Tom Russell: "Õpetajakoolitust tuleks alustada praktikast" / Liisa Lumiste

    Index Scriptorium Estoniae

    Lumiste, Liisa

    2013-01-01

    Eduko programmi raames Tallinna Ülikoolis toimunud avalikul loengul rääkis Kanada kasvatusteadlane Tom Russell praktika tähtsusest õpetajakoolituses ja viis läbi meistriklassi õpetajakoolituse õppejõududele

  14. Russell-Silver syndrome associated with low conus medullaris.

    Science.gov (United States)

    Gabor, Larisa; Canaz, Huseyin; Canaz, Gokhan; Kara, Nursu; Alatas, Ibrahim; Bozkus, Hakan

    2016-01-01

    Russell-Silver syndrome is a rare heterogeneous disorder mainly characterized by intrauterine and postnatal growth retardation, craniofacial disproportion, clinodactyly, variation in urogenital development, and skeletal asymmetry. It is rare to come across tethered cord-associated Russell-Silver syndrome. We report a rare case of Russell-Silver syndrome associated with low conus medullaris in a 2-year-old patient with demonstrative phenotype. Magnetic resonance imaging indicated a low conus medullaris at the inferior border of the L3 vertebral body. Urodynamic study revealed detrusor-sphincter dyssynergia and detrusor overactivity. A decision to follow-up the patient was made because of the suspicion of tethered cord syndrome. Even though tethered cord syndrome is not a common finding in Russell-Silver syndrome, it is important to consider tethered cord syndrome to avoid scoliosis and other long-term complications.

  15. Exploring Ethnic Inequalities in Admission to Russell Group Universities.

    Science.gov (United States)

    Boliver, Vikki

    2016-04-01

    This article analyses national university applications and admissions data to explore why ethnic minority applicants to Russell Group universities are less likely to receive offers of admission than comparably qualified white applicants. Contrary to received opinion, the greater tendency of ethnic minorities to choose highly numerically competitive degree subjects only partially accounts for their lower offer rates from Russell Group universities relative to white applicants with the same grades and 'facilitating subjects' at A-level. Moreover, ethnic inequalities in the chances of receiving an admissions offer from a Russell Group university are found to be greater in relation to courses where ethnic minorities make up a larger percentage of applicants. This latter finding raises the possibility that some admissions selectors at some Russell Group universities may be unfairly rejecting a proportion of their ethnic minority applicants in an attempt to achieve a more ethnically representative student body.

  16. Tom Russell: "Õpetajakoolitust tuleks alustada praktikast" / Liisa Lumiste

    Index Scriptorium Estoniae

    Lumiste, Liisa

    2013-01-01

    Eduko programmi raames Tallinna Ülikoolis toimunud avalikul loengul rääkis Kanada kasvatusteadlane Tom Russell praktika tähtsusest õpetajakoolituses ja viis läbi meistriklassi õpetajakoolituse õppejõududele

  17. e-assessment practice at Russell Group Universities\\ud

    OpenAIRE

    2015-01-01

    The Learning Technology & Innovation (LTI) at the London School of Economics & Political Science (LSE) undertook a study on e-assessment practice across Russell Group universities in an effort to better understand the current e-assessment landscape and the various institutional factors affecting the degree of engagement with e-assessment practice. This report details the results of the online survey relating to all Russell Group universities while providing a focused analysis on LSE from a co...

  18. Empirical Limits on the Russell Conjecture

    CERN Document Server

    Reddick, Rachel

    2013-01-01

    The Russell Conjecture states that there is an unproven possibility of small (<1 m) hollow heat-resistant objects (HoHOs) in Earth orbit or otherwise present in the inner solar system or asteroid belt. While such objects are not the current target of any ongoing searches, we can place stringent limits on their presence using current optical and infrared surveys. The high albedo of HoHOs partially compensates for their small size. As such, we find that no HoHOs greater than 10 cm in radius to a distance of at least 30,000 km, by the Air Force Space Surveillance System. Objects of that size in a stable orbit at 384,000 km (the Earth-Moon distance) may be detected and confirmed by more infrequent, deeper sweeps of the same system. However, it remains possible for undetected HoHOs to exist in near-Earth or Martian orbit. We discuss the prospects of finding such HoHOs in the near future with new telescopes such as LSST.

  19. 75 FR 77665 - Frank Russell Company, Administrative Service Center, Including On-Site Leased Workers From Volt...

    Science.gov (United States)

    2010-12-13

    ... Employment and Training Administration Frank Russell Company, Administrative Service Center, Including On... for Worker Adjustment Assistance on July 30, 2010, applicable to workers of Frank Russell Company..., Washington location of Frank Russell Company, Administrative Service Center. The Department has determined...

  20. Síndrome de Silver-Russell: relato de caso Silver-Russell Syndrome: case report

    Directory of Open Access Journals (Sweden)

    Natalia Freitas Rossi

    2006-12-01

    Full Text Available OBJETIVO: descrever o fenótipo da síndrome de Silver-Russell (SSR e apresentar um caso diagnosticado com esta afecção genética, abordando aspectos genéticos, psicológicos e fonoaudiológicos. MÉTODOS: trata-se de relato de caso de uma criança do gênero feminino, sete anos e onze meses, portadora da síndrome de Silver-Russel. Foram realizadas avaliação genética médica e molecular, avaliação psicológica, avaliação fonoaudiológica e aplicação de testes complementares. RESULTADOS: a análise molecular da região 7p11 excluiu a dissomia uniparental para este caso. No exame físico foram constatados os principais sinais clínicos da SSR que incluiu retardo no crescimento de origem pré-natal, fácies típica, assimetrias ósseas e clinodactilia do 5º dedo. A avaliação cognitiva e fonoaudiológica mostraram deficiência mental, distúrbio de linguagem oral e comprometimento das funções orais. CONCLUSÃO: o estudo deste caso possibilitou a divulgação do fenótipo da SSR com suas manifestações físicas, cognitivas e fonoaudiológicas. Embora o teste molecular não tenha confirmado um dos possíveis mecanismos etiológicos da síndrome, a avaliação genética médica constatou a presença dos principais sinais clínicos que foram correlacionados à literatura. A avaliação psicológica e fonoaudiológica apontaram para comprometimento cognitivo e de comunicação, funções orais , sugerindo que importantes alterações fonoaudiológicas podem fazer parte do fenótipo desta síndrome, ainda pouco difundida para fonoaudiólogos.PURPOSE: to describe Silver-Russell syndrome (SRS phenotype and report a case with this condition, concerning genetics, psychological and speech/language and oral function evaluation. METHODS: we will submit the case of a girl, seven years and eleven months with Silver-Russell syndrome. Medical genetic evaluation, molecular test, psychological and speech/language evaluation was done. Complementary

  1. Russell body gastritis: case report Gastrite com corpúsculos de Russell: relato de caso

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2012-02-01

    Full Text Available Russell body gastritis (RBG, which can be associated with Helicobacter pylori (HP infection, is a recently acknowledged lesion characterized by the presence of eosinophilic intracytoplasmic inclusions in plasmacytes. Herein the authors discuss the morphological aspects of a case of RBG in a male patient with clinical complaint of epigastric pain. Upper endoscopy revealed areas of erythema/edema in the antrum. As far as microscopy is concerned, a mononuclear inflammatory infiltrate was identified on the lamina propria, with plasma cells containing Schiff acid periodic (PAS positive eosinophilic intracytoplasmic globules, which showed positive immunostaining for CD79a, CD138, and kappa/lambda light chains. HP was identified by Giemsa stains.A gastrite com corpúsculos de Russell (RBG, que pode estar associada à infecção por Helicobacter pylori (HP, é uma lesão recentemente reconhecida que se caracteriza pela presença de inclusões eosinofílicas intracitoplasmáticas em plasmócitos. Neste relato, os autores discutem os aspectos morfológicos de um caso de RBG em um paciente masculino com queixa clínica de dor epigástrica. A endoscopia revelou áreas de eritema/edema no antro. À microscopia, um infiltrado inflamatório mononuclear foi identificado na lâmina própria, com plasmócitos exibindo glóbulos eosinofílicos intracitoplasmáticos ácido periódico de Schiff (PAS positivos, que apresentaram imunoexpressão positiva para CD79a,CD138 e cadeias leves kappa/lambda. HP foi identificado na coloração de Giemsa.

  2. Myotonia congenita in a Jack Russell terrier : clinical communication

    Directory of Open Access Journals (Sweden)

    R.G. Lobetti

    2009-05-01

    Full Text Available A 4-month-old male Jack Russell terrier was evaluated for non-painful muscle spasms and collapse associated with exercise and activity. Clinical examination revealed well-defined, non-painful hypertrophic muscles of the fore and hind limbs and exercise and excitement induced hindquarter bunny-hopping gait, which improved with activity but worsened with resting and with any sudden changes in direction of movement. Neurological examination and routine laboratory testing showed no abnormalities. DNA analysis for myotonia congenita showed the dog to have a gene mutation in the chloride ion channel, diagnostic for myotonia congenita, which has not been reported in the Jack Russell terrier breed.

  3. Estimating phase integrals - A generalization of Russell's law

    Science.gov (United States)

    Verbiscer, Anne J.; Veverka, Joseph

    1988-01-01

    An attempt is made to demonstrate, by means of Hapke's (1981) photometric function, that a simple and reliable method exists for the estimation of phase integrals from limited higher phase angle measurements. This method is a generalization of the approximation first proposed by Russell (1916) and more recently treated by Veverka (1971). It is shown that this generalization of Russell's law can employ observations anywhere in the range of phase angles from 40 to 90 deg; optimum estimates of q will be obtained if the data near 70 deg are obtainable.

  4. 76 FR 37857 - Russell Exchange Traded Funds Trust, et al.; Notice of Application

    Science.gov (United States)

    2011-06-28

    ... COMMISSION Russell Exchange Traded Funds Trust, et al.; Notice of Application June 22, 2011. AGENCY... the Act for an exemption from sections 12(d)(1)(A) and (B) of the Act. APPLICANTS: Russell Exchange Traded Funds Trust (formerly, U.S. One Trust, the ``Trust''), Russell Investment Management Company...

  5. 76 FR 142 - Notice of Prevention of Significant Deterioration Final Determination for Russell City Energy Center

    Science.gov (United States)

    2011-01-03

    ... AGENCY Notice of Prevention of Significant Deterioration Final Determination for Russell City Energy... Petitions for Review of a Federal Prevention of Significant Deterioration (PSD) Permit issued to Russell... agreement dated February 4, 2008, issued a PSD permit to Russell City Energy Center, LLC, on February 3...

  6. Channels on Dunes in Russell Crater

    Science.gov (United States)

    2006-01-01

    Hundreds of enigmatic small channels are seen to carve into the slopes of these dark sand dunes lying within Russell Crater on Mars. These features were previously identified as gullies in images from the Mars Orbiter Camera (MOC) on Mars Global Surveyor, but the higher resolution HiRISE image brings out many new details and mysteries. The channels extend from near the top of the dunes to their bases, indicating that some fluid material carved into the sand. The channels commonly begin as smaller tributaries joined together, suggesting several sources of fluid. Distinct dark spots are located near where the channels seem to originate. Several channels appear to originate at alcoves. Several of these channels have sinuous middle reaches while others are straighter. Further down slope, some channel edges appear elevated above the surrounding terrain, particularly in the lower reaches. The channels seem to terminate abruptly, with no deposition of material, unlike at the bases of some other gullies on Mars that are not on dunes. One hypothesis for the origin of the channels, which has previously been proposed by the MOC team, is that CO2 (or maybe H2O) frost is deposited on the dunes in shadows or at night. Some frost may also be incorporated into the internal parts of the dunes due to natural avalanching. When the frost is eventually heated by sunlight, rapid sublimation triggers an avalanche of fluidized sand, forming a gully. HiRISE will continue to target small channel features such as these and may return to search for any changes over time. Image PSP_001440_1255 was taken by the High Resolution Imaging Science Experiment (HiRISE) camera onboard the Mars Reconnaissance Orbiter spacecraft on November 16, 2006. The complete image is centered at -54.2 degrees latitude, 12.9 degrees East longitude. The range to the target site was 251.4 km (157.1 miles). At this distance the image scale is 50.3 cm/pixel (with 2 x 2 binning) so objects 151 cm across are resolved. The

  7. Epigenoty-pephenotype correlations in Silver-Russell syndrome

    NARCIS (Netherlands)

    Wakeling, E. L.; Abu Amero, S.; Alders, M.; Bliek, J.; Forsythe, E.; Kumar, S.; Lim, D. H.; MacDonald, F.; Mackay, D. J.; Maher, E. R.; Moore, G. E.; Poole, R. L.; Price, S. M.; Tangeraas, T.; Turner, C. L. S.; Van Haelst, M. M.; Willoughby, C.; Temple, I. K.; Cobben, J. M.

    2010-01-01

    Background Silver Russell syndrome (SRS) is characterised by intrauterine growth restriction, poor postnatal growth, relative macrocephaly, triangular face and asymmetry. Maternal uniparental disomy (mUPD) of chromosome 7 and hypomethylation of the imprinting control region (ICR) 1 on chromosome 11p

  8. Epigenoty-pephenotype correlations in Silver-Russell syndrome

    NARCIS (Netherlands)

    Wakeling, E. L.; Abu Amero, S.; Alders, M.; Bliek, J.; Forsythe, E.; Kumar, S.; Lim, D. H.; MacDonald, F.; Mackay, D. J.; Maher, E. R.; Moore, G. E.; Poole, R. L.; Price, S. M.; Tangeraas, T.; Turner, C. L. S.; Van Haelst, M. M.; Willoughby, C.; Temple, I. K.; Cobben, J. M.

    2010-01-01

    Background Silver Russell syndrome (SRS) is characterised by intrauterine growth restriction, poor postnatal growth, relative macrocephaly, triangular face and asymmetry. Maternal uniparental disomy (mUPD) of chromosome 7 and hypomethylation of the imprinting control region (ICR) 1 on chromosome 11p

  9. Telling Lewis Hine's Story: Russell Freedman's "Kids at Work."

    Science.gov (United States)

    Zarnowski, Myra

    In "Kids at Work," Russell Freedman explores the world of child labor during the years 1908-1918 when Lewis Hine, "teacher-crusader," worked as an investigative photographer for the National Child Labor Committee (NCLC). Hine's writing and the photos he gathered from across the country revealed a "shocking reality that…

  10. A New Method for Obtaining Russell-Saunders Terms

    Science.gov (United States)

    Liu, Ying; Liu, Yue; Liu, Bihui

    2011-01-01

    A new method for obtaining Russell-Saunders terms of atomic configurations is reported. This new method is significantly different from, while at the same time complementary to, previously published methods for obtaining atomic terms. This novel procedure is elicited by the method used to determine the splitting of S, P, D terms in weak ligand…

  11. Astronaut Russell Schweickart inside simulator for EVA training

    Science.gov (United States)

    1968-01-01

    Astronaut Russell L. Schweickart, lunar module pilot of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission, is seen inside Chamber 'A', Space Environment Simulation Laboratory, bldg 32, participating in dry run activity in preparpation for extravehicular activity.

  12. Is Russell's vicious circle principle false or meaningless?

    NARCIS (Netherlands)

    Fleischhacker, L.E.

    1979-01-01

    P. Vardy asserts the thesis that the vicious circle principle has the same structure as Russell's paradox. But structure is not the thing itself. It is the thing objectivated from the wiewpoint of a mathematician. So this structure can be expressed in a mathematical formalism, e. g. the Λ-calculus.

  13. Obituary: Russell Makidon (1971-2009)

    Science.gov (United States)

    Sivaramakrishnan, Anand

    2009-12-01

    Russell Benjamin Makidon died at the age of 38 in Baltimore on June 22, 2009. Complications following surgery to remove a tumor cut his life tragically short. Russ was a Mission Systems Scientist at the Space Telescope Science Institute (STScI), which he joined straight out of graduate school in 1997. He brought both the force of his intellect and his superb people skills to STScI, where he served the Institute and the broader community with extraordinary effectiveness. Russ was pivotal in helping to develop the wavefront sensing and control system of the James Webb Space Telescope (JWST). He was also a member of the NSF Center for Adaptive Optics at Lick Observatory. Born to Cathy Ann and Peter Makidon, a worker at General Motors, on January 22, 1971, in Bay City, Michigan, Russ was an only child. He was raised by his mother, in Florida, and her parents, in Munger, Michigan. He is survived by his mother, his grandfather Benjamin Franklin Histed, and his father. In addition to his interest in science, Russ was a talented artist and his sketches had appeared in statewide and national competitions. Turning down a scholarship at the Savannah College of Art and Design, he studied physics and astronomy at the University of Michigan, followed by a Masters under Stephen Strom at the University of Massachusetts. He measured pre-main sequence stellar rotation in NGC 2264 and other OB associations, providing insight on the role that circumstellar disks play in setting stellar angular momentum in young stellar clusters and associations. This work, and his extraordinary skills in facilitating scientific exchange, led to his co-investigatorship on the Hubble Space Telescope (HST) Orion Treasury Project. Russ advanced the understanding of high contrast imaging, especially the relation between the properties of a wavefront control or adaptive optics systems and the physics of coronagraphic imaging. He developed a practical understanding of coronagraphy, performing timely and

  14. The spectroscopic Hertzsprung-Russell diagram of Galactic massive stars

    CERN Document Server

    Castro, N; Langer, N; Simón-Díaz, S; Schneider, F R N; Izzard, R G

    2014-01-01

    The distribution of stars in the Hertzsprung-Russell diagram narrates their evolutionary history and directly assesses their properties. Placing stars in this diagram however requires the knowledge of their distances and interstellar extinctions, which are often poorly known for Galactic stars. The spectroscopic Hertzsprung-Russell diagram (sHRD) tells similar evolutionary tales, but is independent of distance and extinction measurements. Based on spectroscopically derived effective temperatures and gravities of almost 600 stars, we derive for the first time the observational distribution of Galactic massive stars in the sHRD. While biases and statistical limitations in the data prevent detailed quantitative conclusions at this time, we see several clear qualitative trends. By comparing the observational sHRD with different state-of-the-art stellar evolutionary predictions, we conclude that convective core overshooting may be mass-dependent and, at high mass ($\\geq 15\\,M_\\odot$), stronger than previously thou...

  15. Russell bodies in a skin biopsy: a case report

    Directory of Open Access Journals (Sweden)

    Verheij Joanne

    2009-11-01

    Full Text Available Abstract Introduction The presence of eosinophilic bodies in a skin biopsy can be found in a variety of situations and this may present a challenge to the pathologist. The differential diagnosis of these eosinophilic structures include microorganisms such as histoplasmosis or cryptococcosis, fungi, Michaelis-Gutmann bodies, deposits of amyloid or immunoglobulins, colloid bodies or elastic bodies. Case presentation During a routine examination of a skin biopsy with actinic keratosis taken from the cheek of a 61-year-old man, clusters of eosinophilic bodies were seen within an inflammatory infiltrate in the dermis, both intracytoplasmic and extracellular. Using additional immunohistochemical staining, these structures were identified as polyclonal Russell bodies. Conclusion The differential diagnosis of intracytoplasmic eosinophilic structures in a skin biopsy includes Russell bodies, an uncommon finding that may be associated with chronic inflammatory conditions.

  16. How to release Frege's system from Russell's antinomy

    CERN Document Server

    Cattabriga, Paola

    2007-01-01

    The conditions for proper definitions in mathematics are given, in terms of the theory of definition, on the basis of the criterions of eliminability and non-creativity. As a definition, Russell's antinomy is a violation of the criterion of eliminability (Behmann, 1931; Bochvar, 1943). Following the path of the criterion of non-creativity, this paper develops a new analysis of Comprehension schema and, as a consequence, proof that Russell's antinomy argumentation, despite the words of Frege himself, does not hold in Grundgesetze der Arithmetik. According to Basic Law (III), the class of classes not belonging to themselves is a class defined by a function which can not take as argument its own course of value. In other words, the class of classes not belonging to themselves is a class whose classes are not identical to the class itself.

  17. Russell And Frege On The Logic of Functions

    Directory of Open Access Journals (Sweden)

    Bernard Linsky

    2009-10-01

    Full Text Available I compare Russell’s theory of mathematical functions, the “descriptive functions” from Principia Mathematica ∗30, with Frege’s well known account of functions as “unsaturated” entities. Russell analyses functional terms with propositional functions and the theory of definite descriptions. This is the primary technical role of the theory of descriptions in P M . In Principles of Mathematics and some unpublished writings from before 1905, Russell offered explicit criticisms of Frege’s account of functions. Consequenly, the theory of descriptions in “On Denoting” can be seen as a crucial part of Russell’s larger logicist reduction of mathematics,aswellasanexcursionintothetheoryof reference.

  18. Diagnosis and management of Silver-Russell syndrome

    DEFF Research Database (Denmark)

    Wakeling, Emma L; Brioude, Frédéric; Lokulo-Sodipe, Oluwakemi

    2017-01-01

    This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver-Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Considerable overlap exists between the care of individuals born...... and speech delay and psychosocial challenges. An early emphasis on adequate nutritional status is important, with awareness that rapid postnatal weight gain might lead to subsequent increased risk of metabolic disorders. The benefits of treating patients with SRS with growth hormone include improved body...

  19. Some early similarities and later differences between Bertrand Russell and B. F. Skinner

    OpenAIRE

    Moxley, Roy A.

    2003-01-01

    B. F. Skinner credited Bertrand Russell with converting him to behaviorism and with writing one of the books that most influenced him. Particularly in Skinner's early work, there are similarities between Skinner and Russell that extend across mathematics, determinism, positivism, verbal behavior, future communities, evolution, and pragmatism. Later, Skinner's views changed, and he parted company with Russell in most of these areas. Perhaps the most dramatic and fundamental departure came when...

  20. Helicobacter pylori-negative Russell body gastritis: case report.

    Science.gov (United States)

    Del Gobbo, Alessandro; Elli, Luca; Braidotti, Paola; Di Nuovo, Franca; Bosari, Silvano; Romagnoli, Solange

    2011-03-07

    Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions. Very few cases have been reported in the literature; the majority of which have shown Helicobacter Pylori (H. pylori) infection, thus suggesting a correlation between plasma cell presence and antigenic stimulation by H. pylori. We present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophagogastroduodenoscopy for epigastric pain. Gastric biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink bodies. Giemsa staining for H. pylori infection was negative, as well as immunohistochemical detection. The cells with eosinophilic inclusions stained positive for CD138, CD79a, and κ and lambda light chains, which confirmed plasma cell origin. In particular, κ and lambda light chains showed a polyclonal origin and the patient was negative for immunological dyscrasia. The histological observations were confirmed by ultrastructural examination. The cases reported in the literature associated with H. pylori infection have shown regression of plasma cells after eradication of H. pylori. Nothing is known about the progression of H. pylori-negative cases. The unusual morphological appearance of this type of chronic gastritis should not be misinterpreted during routine examination, and it should be distinguished from other common forms of chronic gastritis. It is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy, which can help with differential diagnosis. The long-term effects of plasma cells hyperactivation are still unknown, because cases of gastric tumor that originated in patients affected by Russell body gastritis have not been described in the literature. We are of the opinion that these patients should be scheduled

  1. Helicobacter pylori-negative Russell body gastritis: Case report

    Institute of Scientific and Technical Information of China (English)

    Alessandro Del Gobbo; Luca Elli; Paola Braidotti; Franca Di Nuovo; Silvano Bosari; Solange Romagnoli

    2011-01-01

    Russell body gastritis is an unusual form of chronic gas-tritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions. Very few cases have been reported in the lit-erature; the majority of which have shown Helicobacter Pylori (H. pylori) infection, thus suggesting a correlation between plasma cell presence and antigenic stimulation by H. pylori. We present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophago-gastroduodenoscopy for epigastric pain. Gastric biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink bodies. Giemsa staining for H. pylori infection was nega-tive, as well as immunohistochemical detection. The cells with eosinophilic inclusions stained positive for CD138, CD79a, and κ and lambda light chains, which confirmed plasma cell origin. In particular, κ and lambda light chains showed a polyclonal origin and the patient was negative for immunological dyscrasia. The histologi-cal observations were confirmed by ultrastructural ex-amination. The cases reported in the literature associated with H. pylori infection have shown regression of plasma cells after eradication of H. pylori. Nothing is known about the progression of H. pylori-negative cases. The unusual morphological appearance of this type of chron-ic gastritis should not be misinterpreted during routine examination, and it should be distinguished from other common forms of chronic gastritis. It is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy, which can help with differential diagnosis. The long-term effects of plasma cells hyper-activation are still unknown, because cases of gastric tu-mor that originated in patients affected by Russell body gastritis have not been described in the literature. We are of the opinion that these patients should be

  2. Bertrand Russell: pacifismo político relativo

    Directory of Open Access Journals (Sweden)

    Francisco A. Laca-Arocena

    2011-01-01

    Full Text Available Siguiendo la biografía de Bertrand Russell (1872-1970, lógico matemático, filósofo, premio Nobel de Literatura 1950 y militante pacifista a lo largo de gran parte del conflictivo siglo XX, se analiza el doble conflicto que afronta un pacifista: de desobediencia civil a un gobierno que ha declarado una guerra y de relativa marginación social con una opinión pública cuando ésta es mayoritariamente favorable a esa guerra. Tras un breve análisis del pacifismo contrastándolo con una doble tradición en el pensamiento político anglosajón, el utilitarismo y la teoría del contrato social, se incide en la distinción personal de Russell entre guerras ¿de prestigio¿ y ¿de valores¿. Fue pacifista en la Primera Guerra Mundial considerándola una guerra de prestigio, pero fue partidario de oponerse al nazismo en la Segunda Guerra entendiendo que se trataba de un combate de valores. Volvería a un activismo pacifista en su oposición a la guerra de Vietnam. Estas diferentes posiciones ante la guerra en relación con lo que en cada caso esté en juego, se conoce como ¿pacifismo político relativo¿, cuyo representante más genuino fue el propio Russell.

  3. The Church in the Thought of Charles Taze Russell

    Science.gov (United States)

    1990-07-01

    widespread anxiety over religious pluralism. Once Russell became convinced that the Bible could be correct and that Christendom had misrepresented its truth...for the church to separate itself from nominal Christendom . We admonish the New Creation to have nothing whatever to do with any of these semi-relig...only to the Lord and to those who have his Spirit . To what are they to come? As of 1893, we read: The true view, as we conceive it, is as follows: God’s

  4. Destructive Cholangitis in an Adult Jack Russell Terrier

    Directory of Open Access Journals (Sweden)

    Atsushi Kodama

    2012-01-01

    Full Text Available A 4-year-old female Jack Russell terrier dog exhibited vomiting and severe jaundice of the visible mucous membranes and skin. Ultrasonography revealed diffuse areas of high echogenicity and focal areas of low echogenicity in the left lobe of the liver. On macroscopic observation of the biopsied liver specimen, many scattered irregularly shaped red spots were observed on the liver surface and on the cut surface. Histopathologically, there was loss of the interlobular bile duct and cholangitis accompanied by infiltration of pigment-laden macrophages in the Glisson’s capsule. Therefore, in the present case the dog was diagnosed with destructive cholangitis.

  5. Alfred Russell Wallace and the evolution of the human mind.

    Science.gov (United States)

    Gross, Charles

    2010-10-01

    Today the fame of Alfred Russell Wallace is as the independent codiscoverer with Charles Darwin of the origin of species by natural selection. Although they were on very amiable terms all their lives, 11 years after announcing their discovery, Wallace and Darwin had a major disagreement on the evolution of human cognition. The author considers how this divergence and other disagreements, particularly on the role of instinct, are related to the differences in their class backgrounds, education, experience with non-European cultures, and views on socialism, phrenology, mesmerism, and spiritualism.

  6. Astronaut Russell Schweickart wears EMU and PLSS for countdown test

    Science.gov (United States)

    1969-01-01

    Astronaut Russell L. Schweickart, lunar module pilot of the Apollo 9 prime crew, wears the extravehicular mobility unit (EMU) which he will use during his scheduled Apollo 9 extravehicular activity. In addition to the space suit and bubble helmet, the EMU also includes a portable life support system (PLSS) back pack, an Oxygen Purge System (seen atop the PLSS), and a Remote Control Unit on his chest. When this photograph was taken, Schweickart was suited up to participate in an Apollo 9 Countdown Demonstration Test.

  7. 76 FR 14101 - Bruss North America; Russell Springs, KY; Bruss North America; Orion, MI; Amended Revised...

    Science.gov (United States)

    2011-03-15

    ... Employment and Training Administration Bruss North America; Russell Springs, KY; Bruss North America; Orion... Springs, Kentucky. The workers are engaged in the production of automobile parts and component parts. The... production of automobile parts at the Russell Springs, Kentucky location of Bruss North America. The...

  8. 76 FR 7590 - Bruss North America Russell Springs, Kentucky; Notice of Revised Determination on Reconsideration

    Science.gov (United States)

    2011-02-10

    ... Employment and Training Administration Bruss North America Russell Springs, Kentucky; Notice of Revised... workers of Bruss North America, Russell Springs, Kentucky (subject firm), regarding their application for... Springs, Kentucky, who are engaged in employment related to the production of automobile parts...

  9. From the Lab Bench: A tribute to Russell Hackley, a true grass farmer

    Science.gov (United States)

    An article was written about the legacy of Russell Hackley, a stocker producer from Grayson County, who passed away on June 11, 2016 and was a strong advocate for the cattle and forage industries. In memory of Russell, I would like to discuss some things I overheard him say about agriculture and fo...

  10. Russell Crowe maailma tipust maailma äärele / Timo Diener

    Index Scriptorium Estoniae

    Diener, Timo

    2003-01-01

    Näitleja Russell Crowe ja tema suhe oma rolliga seiklusfilmis "Kapten ja komandör : retk maailma äärele" ("Master and Commander : The Far Side of the World") : stsenarist Patrick O'Briani romaanide järgi ja režissöör Peter Weir : peaosas Russell Crowe : Ameerika Ühendriigid 2003

  11. Letty M. Russell: A Feminist Liberation Approach to Educating for Justice

    Science.gov (United States)

    Brady, Judith Ann

    2008-01-01

    This article examines the Rev. Dr. Letty M. Russell's feminist liberation approach to educating for justice by reviewing the major themes in her writings. Educating for justice was rooted in Russell's life and ministry, namely, a sense of God's mission to reconcile and mend the world; partnership as sharing in God's mission to effect justice; and…

  12. Russell Crowe maailma tipust maailma äärele / Timo Diener

    Index Scriptorium Estoniae

    Diener, Timo

    2003-01-01

    Näitleja Russell Crowe ja tema suhe oma rolliga seiklusfilmis "Kapten ja komandör : retk maailma äärele" ("Master and Commander : The Far Side of the World") : stsenarist Patrick O'Briani romaanide järgi ja režissöör Peter Weir : peaosas Russell Crowe : Ameerika Ühendriigid 2003

  13. Woods and Russell, Hill, and the emergence of medical statistics

    Science.gov (United States)

    Farewell, Vern; Johnson, Tony

    2010-01-01

    In 1937, Austin Bradford Hill wrote Principles of Medical Statistics (Lancet: London, 1937) that became renowned throughout the world and is widely associated with the birth of modern medical statistics. Some 6 years earlier Hilda Mary Woods and William Thomas Russell, colleagues of Hill at the London School of Hygiene and Tropical Medicine, wrote a similar book An Introduction to Medical Statistics (PS King and Son: London, 1931) that is little known today. We trace the origins of these two books from the foundations of early demography and vital statistics, and make a detailed examination of some of their chapters. It is clear that these texts mark a watershed in the history of medical statistics that demarcates the vital statistics of the nineteenth and early twentieth centuries from the modern discipline. Moreover, we consider that the book by Woods and Russell is of some importance in the development of medical statistics and we describe and acknowledge their place in the history of this discipline. Copyright © 2010 John Wiley & Sons, Ltd. PMID:20535761

  14. 76 FR 32226 - Russell Newman, Inc., a Subsdiary of RNA Holdings, LLC, Including On-Site Leased Workers From...

    Science.gov (United States)

    2011-06-03

    ... Employment and Training Administration Russell Newman, Inc., a Subsdiary of RNA Holdings, LLC, Including On...; Russell Newman, Inc., a Subsidiary of RNA Holdings, LLC, Great Barrington, MA; RNA Holdings, LLC, a... Adjustment Assistance on March 3, 2011, applicable to workers of Russell Newman, Inc., a subsidiary of RNA...

  15. 75 FR 39046 - Russell Brands, LLC, Fabrics Division, a Subsidiary of Fruit of the Loom, Including Employees...

    Science.gov (United States)

    2010-07-07

    ... Employment and Training Administration Russell Brands, LLC, Fabrics Division, a Subsidiary of Fruit of the... Eligibility to Apply for Worker Adjustment Assistance on December 10, 2009, applicable to workers of Russell... workers of Russell Brands, LLC, Fabric Division, a subsidiary of Fruit of the Loom, including employees...

  16. "Russell Body Gastroenterocolitis" in a Posttransplant Patient: A Case Report and Review of Literature.

    Science.gov (United States)

    Muthukumarana, Vidarshi; Segura, Sheila; O'Brien, Miechelle; Siddiqui, Rina; El-Fanek, Hani

    2015-12-01

    Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated rough endoplasmic reticulum cisternae. Russell body gastritis was first described 1998 by Tazawa and Tsutsumi. Since then only 39 cases involving the gastrointestinal tract have been reported in English literature, which include Russell body gastritis, duodenitis, and esophagitis. We report a case of a 44-year-old female with a history of diabetes mellitus, status post kidney and pancreas transplant who presented with multiple episodes of watery diarrhea associated with abdominal pain, nausea, and vomiting. Upper gastroendoscopic examination showed diffuse mild erythema in the gastric body and a clean-based duodenal ulcer. Lower gastroendoscopic examination was normal. Examination of multiple biopsies from duodenal, gastric, terminal ileum, and colonic mucosae revealed numerous plasma cells with abundant eosinophilic granular cytoplasm (Russell bodies) and eccentric nuclei, highlighted by PAS stain and CD 138 plasma cell marker. Helicobacter pylori stains were performed on gastric biopsies and were negative for organisms. To date, there are no cases described in English literature with multifocal Russell body infiltrates in gastrointestinal tract in a single patient including ileum and/or colon. This makes our case the first to be reported with these unique findings; thus, the spectrum of Russell body-associated chronic inflammation of the gastrointestinal tract would be more suitably referred to as "Russell body gastroenterocolitis." © The Author(s) 2015.

  17. A Family with Russel Silver Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Alpaslan Tuzcu

    2004-01-01

    Full Text Available Russel Silver Syndrome (RSS is a very rare syndrome with phenotypicchanges and its etiology has not explained yet. In 1953 and 1954, a specialgroup of Intrauterin Growth Reterdation, childiren with short staturealong a small triangular face, low-set ears, incurved fifth fingers and othercharactheristics were described. Our patient who come us with shortstature was a twenty years old man. His parents were relatives and he wasthe second child of a family with six children. His length was 155 cm, under-3SD. Also he had a small triangular face, his lips were towards downrightand a small mandibula. Incurved fifth fingers and short stature werepresent in all members of the family.As the result, RSS must be thought inpatients with short sature, especially who has similar phenotypicspecialities as our patient.

  18. Semi-analytical formulas for the Hertzsprung-Russell diagram

    Directory of Open Access Journals (Sweden)

    Zaninetti L.

    2008-01-01

    Full Text Available The absolute visual magnitude as function of the observed color (B-V, also named Hertzsprung-Russell diagram, can be described through five equations; that when calibrated stars are available means eight constants. The developed framework allows to deduce the remaining physical parameters, mass, radius and luminosity. This new technique is applied to the first 10 pc, the first 50 pc, the Hyades and to the determination of the distance of a cluster. The case of the white dwarfs is analyzed assuming the absence of calibrated data: our equation produces a smaller χ2 with respect to the standard color-magnitude calibration when applied to the Villanova Catalog of Spectroscopically Identified White Dwarfs. The theoretical basis of the formulas for the colors and the bolometric correction of the stars is clarified by a Taylor expansion in the temperature of the Planck distribution.

  19. SINDROME DE SILVER-RUSSELL, REPORTE DE UN CASO

    OpenAIRE

    Ángela Liliana Grandas Ramírez; Natalia Cardenas Niño; Claudia Milena Rincón Bermúdez

    2012-01-01

    El síndrome Silver-Russell es un desorden genético (hipometilación en la región centro 1 (ICR1) del  IGF2 /H19  locus 11p15) y clínicamente heterogéneo, caracterizado por retardo del crecimiento intrauterino, baja talla y peso, y perímetro cefálico normal. Su tratamiento se basa en la  hormona del crecimiento. Se presenta el caso de una niña de 5 años que ingresa al servicio de Estomatología Pediátrica de la Fundación HOMI Hospital de la Misericordia de Bogotá, con antecedente de retardo del ...

  20. The Russell gold deposit, Carolina Slate Belt, North Carolina

    Science.gov (United States)

    Klein, T.L.; Cunningham, C.G.; Logan, M.A.V.; Seal, R.R.

    2007-01-01

    Gold deposits have been mined in the Carolina slate belt from the early 1800s to recent times, with most of the production from large mines in South Carolina. The Russell mine, one of the larger producers in North Carolina, is located in the central Uwharrie Mountains, and produced over 470 kg of gold. Ore grades averaged about 3.4 grams per tonne (g/ t), with higher-grade zones reported. The Russell deposit is interpreted to be a sediment-hosted, gold-rich, base-metal poor, volcanogenic massive sulfide deposit in which gold was remobilized, in part, during Ordovician metamorphism. The ore was deposited syngenetically with laminated siltstones of the late Proterozoic Tillery Formation that have been metamorphosed to a lower greenschist facies. The Tillery Formation regionally overlies subaerial to shallow marine rhyolitic volcanic and volcaniclastic rocks of the Uwharrie Formation and underlies the marine volcanic and sedimentary rocks of the Cid Formation. Recent mapping has shown that a rhyolitic dome near the Russell mine was extruded during the deposition of the lower part of the Tillery Formation, at about the same time as ore deposition. Relict mafic, rock fragments present in the ore zones suggest contemporaneous bimodal (rhyolite-basalt) volcanism. The maximum formation age of the Russell deposit is younger than 558 Ma, which is similar to that of the larger, well known Brewer, Haile, and Ridgeway deposits of South Carolina. Gold was mined from at least six zones that are parallel to the regional metamorphic foliation. These strongly deformed zones consist of northeast-trending folds, high-angle reverse faults, and asymmetric doubly plunging folds overturned to the southeast. The dominant structure at the mine is an asymmetric doubly plunging anticline with the axis trending N 45?? E, probably related to late Ordovician (456 ?? 2 Ma) regional metamorphism and deformation. Two stages of pyrite growth are recognized. Stage 1, primary, spongy pyrite, is

  1. Democracia, poder y minorías en Bertrand Russell

    Directory of Open Access Journals (Sweden)

    Álvaro Carvajal Villaplana

    2013-11-01

    Full Text Available En este artículo se hace un análisis de la noción de democracia como doma del poder del filósofo analítico Bertrand Russell, idea que aparece en su libro Power (1938. A este concepto se lo vincula con la defensa de las minorías, y en este artículo esta idea se extiende a la defensa de las minorías sexuales. Asimismo, se hace una correlación con el pensamiento de Leibniz de que debe haber un control ético del poder de los gobernantes y con la idea de la democracia vacía de Jacques Ranciére.

  2. Russell's Unknown Logicism A Study in the History and Philosophy of Mathematics

    CERN Document Server

    Gandon, Professor Sebastien

    2012-01-01

    In this excellent book Sebastien Gandon focuses mainly on Russell's two major texts, Principa Mathematica and Principle of Mathematics, meticulously unpicking the details of these texts and bringing a new interpretation of both the mathematical and the philosophical content.

  3. Charles M. Russell National Wildlife Refuge Wilderness Character Monitoring Back-end Database

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is the back-end data file for the Charles M. Russell Wilderness Character Monitoring Application. User interface and lookup databases are required for use (see...

  4. Charles M. Russell NWR administrative inspection, July 25-29, 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is an administrative inspection report for Charles M. Russell National Wildlife Refuge, completed July 25-29, 1994. The following areas were reviewed: buildings...

  5. Charles M. Russell National Wildlife Refuge: Annual narrative report: Calendar year 1981

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1981 calendar year. The report...

  6. Charles M. Russell National Wildlife Refuge: Annual narrative report: Calendar year 1982

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1982 calendar year. The report...

  7. Charles M. Russell National Wildlife Range Wilderness proposal public hearing summary analysis and wilderness study summary

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains both a public hearing summary analysis and a wilderness study summary for the Charles M. Russell National Wildlife Range. The public hearing...

  8. Charles M. Russell National Wildlife Range : Narrative Report : January - December 1964

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges: Hailstone, Halfbreed, Mason, Miller, Yellow Water, War Horse, and Wild...

  9. Charles M. Russell National Wildlife Range : Narrative Report : January - December 1966

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell National Wildlife Range (includes satellite refuges: Hailstone, Halfbreed, Mason, Miller, Yellow Water, War...

  10. Charles M. Russell National Wildlife Range : Narrative Report : January - December 1965

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell National Wildlife Range (includes satellite refuges: Hailstone, Halfbreed, Mason, Miller, Yellow Water, War...

  11. Charles M. Russell National Wildlife Refuge: Annual narrative report: Calendar year 1984

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1984 calendar year. The report...

  12. Charles M. Russell National Wildlife Refuge: Annual narrative report: Calendar year 1985

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR, War Horse NWR, Lake Mason NWR, Hailstone NWR, Halfbreed NWR, Tew WPA, and Spidel WPA outlines Refuge...

  13. Charles M. Russell National Wildlife Refuge: Annual narrative report: Calendar year 1983

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1983 calendar year. The report...

  14. Charles M. Russell National Wildlife Range : Narrative Report : January - December 1967

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell National Wildlife Range (includes satellite refuges: Hailstone, Halfbreed, Mason, Miller, Yellow Water, War...

  15. Charles M. Russell National Wildlife Range : Narrative Report : May- August 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell outlines Refuge accomplishments from May to August of 1963. The report begins by summarizing the weather conditions,...

  16. Charles M. Russell National Wildlife Range : Narrative Report : September to December 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell outlines Refuge accomplishments from September to December of 1963. The report begins by summarizing the weather...

  17. Charles M Russell National Wildlife Refuge [Land Status Map: Sheet 2 of 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This map was produced by the Division of Realty to depict landownership at Charles M. Russell National Wildlife Refuge. It was generated from rectified aerial...

  18. Charles M Russell National Wildlife Refuge [Land Status Map: Sheet 1 of 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This map was produced by the Division of Realty to depict landownership at Charles M. Russell National Wildlife Refuge. It was generated from rectified aerial...

  19. Operations inspection of Charles M. Russell National Wildlife Refuge, July 25-29, 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — An operational inspection regarding the biological program of the Charles M. Russell (CMR) NWR was conducted in conjunction with the comprehensive inspection by the...

  20. Final Environmental Assessment : Livestock Grazing Management Seven Blackfeet Habitat Unit : Charles M. Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final environmental assessment for the grazing management within the Seven Blackfeet Habitat Unit of the Charles M. Russell National Wildlife Refuge, in relation to...

  1. Charles M. Russell National Wildlife Refuge: Annual narrative report: Calendar year 1979

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell National Wildlife Refuge (including the satellite refuges) outlines Refuge accomplishments during the 1979 calendar...

  2. Charles M. Russell National Wildlife Range : Narrative Report : January - April 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell outlines Refuge accomplishments from January through April of 1963. The report begins by summarizing the weather...

  3. Astronaut Russell Schweickart suits up for test of life support system

    Science.gov (United States)

    1968-01-01

    Astronaut Russell L. Schweickart suits up to participate in an altitude verification test of the Apollo Portable Life Support System flight unit in Crew Systems Division's 8-ft. altitude chamber in Building 7, Manned Spacecraft Center (MSC).

  4. Astronaut Russell L. Schweickart on deck prior to water egress training

    Science.gov (United States)

    1968-01-01

    Astronaut Russell L. Schweickart, lunar module pilot of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission, relaxes on the deck of the NASA Motor Vessel Retriever prior to water egress training in the Gulf of Mexico.

  5. O Platonismo de Russell na metafísica e na matemática

    Directory of Open Access Journals (Sweden)

    Guido Imaguire

    2005-06-01

    Full Text Available Neste artigo, analiso o surgimento e a superação do Platonismo em B. Russell, tanto na sua filosofia da matemática como na sua metafísica. Começo por explicitar os argumentos que levaram Russell a aderir ao chamado "Platonismo Proposicional" - posição que será tecnicamente relevante na definição de números. Na seção seguinte, discutirei até que ponto a teoria das descrições definidas determina, necessariamente, uma adesão ao nominalismo, e as dificuldades que surgem para o logicismo conseqüentes do abandono do platonismo. Finalmente, mostrarei como a posição madura de Russell caracteriza-se mais como um reducionismo do que propriamente como um nominalismo, e como este é fundado no princípio do mínimo vocabulário.In this paper, I analyze the emergence and the overcoming of Platonism both in Russell's philosophy of mathematics and his metaphysics. I begin by examining the arguments which led Russell to endorse a position that I term "Propositional Platonism" - this position proves to be relevant for Russell's definition of numbers. In the following section, I address the question of the extent to which Russell's theory of descriptions implies the acceptance of nominalism. Moreover, I examine the difficulties which arise for logicism, if it no longer goes hand in hand with platonism. Finally, I argue argue that Russell's mature position is to be characterized as a form of reductionism rather than as a variant of nominalism

  6. Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome.

    LENUS (Irish Health Repository)

    Fenton, E

    2008-12-01

    Silver-Russell syndrome is a rare genetically heterogeneous disorder in which patients demonstrate intrauterine and postnatal growth retardation, triangular facies, excessive sweating during early childhood, late closure of the anterior fontanelle and skeletal asymmetry. An association with malignancy exists and only one previous intracranial tumour has been reported, a craniopharyngioma. We report the first case of Silver-Russell syndrome associated with a supratentorial juvenile pilocytic astrocytoma.

  7. Engaging History in Collaborative Mythmaking: A Conversation with Russell Banks Engager l’Histoire dans la création des Mythes : Conversation avec Russell Banks

    Directory of Open Access Journals (Sweden)

    Kimberly Rae Connor

    2009-11-01

    Full Text Available A word about Russell BanksRussell Banks was raised in New Hampshire and eastern Massachusetts. The eldest of four children, he grew up in a working-class, hardscrabble world that has played a major role in shaping his writing. Banks (the first in his family to go to college attended Colgate University and later graduated Phi Beta Kappa from the University of North Carolina at Chapel Hill. Before he could support himself as a writer, he tried his hand at plumbing, and worked as a shoe salesma...

  8. Silver-Russell syndrome: genetic basis and molecular genetic testing

    Directory of Open Access Journals (Sweden)

    Binder Gerhard

    2010-06-01

    Full Text Available Abstract Imprinted genes with a parent-of-origin specific expression are involved in various aspects of growth that are rooted in the prenatal period. Therefore it is predictable that many of the so far known congenital imprinting disorders (IDs are clinically characterised by growth disturbances. A noteable imprinting disorder is Silver-Russell syndrome (SRS, a congenital disease characterised by intrauterine and postnatal growth retardation, relative macrocephaly, a typical triangular face, asymmetry and further less characteristic features. However, the clinical spectrum is broad and the clinical diagnosis often subjective. Genetic and epigenetic disturbances can meanwhile be detected in approximately 50% of patients with typical SRS features. Nearly one tenth of patients carry a maternal uniparental disomy of chromosome 7 (UPD(7mat, more than 38% show a hypomethylation in the imprinting control region 1 in 11p15. More than 1% of patients show (submicroscopic chromosomal aberrations. Interestingly, in ~7% of 11p15 hypomethylation carriers, demethylation of other imprinted loci can be detected. Clinically, these patients do not differ from those with isolated 11p15 hypomethylation whereas the UPD(7mat patients generally show a milder phenotype. However, an unambiguous (epigenotype-phenotype correlation can not be delineated. We therefore suggest a diagnostic algorithm focused on the 11p15 hypomethylation, UPD(7mat and cryptic chromosomal imbalances for patients with typical SRS phenotype, but also with milder clinical signs only reminiscent for the disease.

  9. The Solar Eclipse Mural Series by Howard Russell Butler

    Science.gov (United States)

    Pasachoff, J. M.; Olson, R. J. M.

    2016-01-01

    There is a rich trove of astronomical phenomena in works of art by artists from the greater New York area, a trend that is even more pronounced in the oeuvres of New York City residents through the present day. A case in point is the trio of oil paintings by artist (and former physics professor) Howard Russell Butler depicting total solar eclipses in 1918, 1923, and 1925 that are based on his own observations. They were long displayed in the former art-deco building of the Hayden Planetarium of the American Museum of Natural History, the location of this conference. (The Museum also has nine other Butler paintings, none of which are currently exhibited.) Since the eclipse paintings have been in storage for many years, these once famous works are now virtually forgotten. Based on our research as an astronomer who has seen sixty-two solar eclipses and an art historian who has written extensively about astronomical imagery, we will discuss Butler's Solar Eclipse Triptych to explore its place in the history of astronomical imaging.

  10. SINDROME DE SILVER-RUSSELL, REPORTE DE UN CASO

    Directory of Open Access Journals (Sweden)

    Ángela Liliana Grandas Ramírez

    2012-12-01

    Full Text Available El síndrome Silver-Russell es un desorden genético (hipometilación en la región centro 1 (ICR1 del  IGF2 /H19  locus 11p15 y clínicamente heterogéneo, caracterizado por retardo del crecimiento intrauterino, baja talla y peso, y perímetro cefálico normal. Su tratamiento se basa en la  hormona del crecimiento. Se presenta el caso de una niña de 5 años que ingresa al servicio de Estomatología Pediátrica de la Fundación HOMI Hospital de la Misericordia de Bogotá, con antecedente de retardo del crecimiento intrauterino, manejada con dieta rica en carbohidratos y uso de biberón hasta los 2 y medio años, Al examen talla 88 cm y peso 9 Kg,  cara forma triangular, frente prominente, micrognatismo mandibular, apiñamiento dental y caries de la infancia temprana. Se diagnostica con retardo de la edad ósea, dental y morfológica. El tratamiento programa individual riesgo de caries y proveer una alta calidad de salud oral.

  11. Mass loss rates in the Hertzsprung-Russell diagram

    Energy Technology Data Exchange (ETDEWEB)

    Jager, C. de; Nieuwenhuijzen, H.; Hucht, K.A. van der

    1988-02-01

    From the literature we collected values for the rate of mass loss for 271 stars, nearly all of population I, and of spectral types 0 through M. Rates of stellar mass loss determined according to six different methods were compared and appear to yield the same result per star within the limits of errors; this is true regardless of the star's position in the HR-diagram. Thus average rates of mass loss were determined, and weights were allocated to the M-determinations for each star. In addition we studied some groups of other stars: fast rotators (22 Be-type stars), and chemically evolved stars (31 Wolf-Rayet stars; 11 C- and 4 S-type stars and 15 nuclei of planetary nebulae). The chemically evolved stars have rates of mass loss which are larger than those of ''normal'' stars occupying the same positions in the Hertzprung-Russel diagram, by factors: 160 for Wolf-Rayet stars; 11 for C-type stars, and by estimated factors of 10/sup 3/ to 10/sup 4/ for the nuclei of planetary nebulae.

  12. At home among strangers: Alfred Russel Wallace in Russia.

    Science.gov (United States)

    Levit, Georgy S; Polatayko, Sergey V

    2013-12-01

    Alfred Russel Wallace (1823-1913) was an influential figure within Russian pre-Synthetic evolutionary biology, i.e. the time period before the Synthetic Theory of Evolution was established (ca. 1880-1930s). His major works were translated into Russian and his general ideas were read and discussed by both insiders and outsiders of scientific evolutionism. At the same time, Wallace played a controversial role in the growth of Darwinism in Russia, and Charles Robert Darwin (1809-1882) has eclipsed Wallace in his influence on Russian evolutionary thinking. In this paper we briefly outline Wallace’s impact on Russian pre-Synthetic scientific evolutionism and its general intellectual climate. We demonstrate that both Russian pro-Darwinian evolutionists and anti-Darwinians (scientific anti-Darwinians as well as creationists) were fully aware of Wallace’s contributions to the development of evolutionary theory. Yet, Wallace’s radical selectionism, as well as his controversial arguments for “design in nature”, predetermined his special place within the Russian intellectual landscape.

  13. Antiphospholipid syndrome: analysis of dilute Russell's viper venom time titer.

    Science.gov (United States)

    Martinez, Alan P; Cunningham, Mark T

    2016-07-01

    To evaluate the characteristic features of the dilute Russell's viper venom time (DRVVT) titer in the antiphospholipid syndrome (APS). The medical record of 3660 consecutive patients with DRVVT orders between 2006 and 2015 were examined for criteria satisfying the diagnosis of APS. DRVVT titer was studied as a function of titer distribution, titer stability, and clinicopathologic features. Twenty-six patients were diagnosed with APS based on a persistently positive DRVVT and a history of arterial or venous thrombosis. DRVVT titer was mostly of low magnitude (65-77% of patients), was of similar value between initial and repeat testing (mean DRVVT titer 1.40 vs. 1.38; P = 0.858; mean time interval 216 days), and was positively associated with anticardiolipin antibodies (IgG and IgM) and antibeta-2-glycoprotein I antibodies (IgG and IgM) (P antiphospholipid antibody profile in 0 and 62% of patients, respectively (P antiphospholipid antibody profiles.

  14. Howard Russell Butler's Oil Paintings of Solar Eclipses and Prominences

    Science.gov (United States)

    Pasachoff, Jay M.; Olson, Roberta J. M.

    2014-06-01

    Howard Russell Butler (1856-1934) was invited to join the US Naval Observatory expedition to the total solar eclipse of 1918 because of his ability to paint astronomical phenomena based on quickly-made notes about spatial and color details. His giant triptych of the total eclipses of 1918, 1923, and 1925 was proposed for a never-built astronomical center at the American Museum of Natural History and wound up at their Hayden Planetarium when it was constructed in the mid-1930s. Half-size versions are installed at the Fels Planetarium at the Franklin Institute in Philadelphia and at the Firestone Library of Princeton University, whose newly conserved canvases were recently hung; the Buffalo Museum of Science has another half-size version in storage. We discuss not only the eclipse triptychs but also the series of large oil paintings he made of solar prominences (in storage at the American Museum of Natural History) and of his 1932-eclipse and other relevant works.JMP was supported for this work in part by Division III Discretionary Funds and the Brandi Fund of Williams College. His current eclipse research is supported by grants AGS-1047726 from the Solar Research Program of the Atmospheric and Geospace Sciences Division of NSF and 9327-13 from the Committee for Research and Exploration of the National Geographic Society.

  15. Type 1 collagenopathy presenting with a Russell-Silver phenotype.

    Science.gov (United States)

    Parker, Michael J; Deshpande, Charulata; Rankin, Julia; Wilson, Louise C; Balasubramanian, Meena; Hall, Christine M; Wagner, Bart E; Pollitt, Rebecca; Dalton, Ann; Bishop, Nicholas J

    2011-06-01

    Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders of bone formation, resulting in low bone mass and an increased propensity to fracture. It exhibits a broad spectrum of clinical severity, ranging from multiple fractures in utero and perinatal death, to normal adult stature and low fracture incidence. Extra-skeletal features of OI include blue sclera, hearing loss, skin hyperlaxity, joint hyperextensibility, and dentinogenesis imperfecta. The proα1(I) and proα2(I) chains of collagen 1 are encoded by the COL1A1 and COL1A2 genes, respectively; quantitative or qualitative defects in type I collagen synthesis usually manifest as types of OI or some sub-types of EDS. The majority of patients (about 90%) with a clinical diagnosis of OI have a mutation in the COL1A1 or COL1A2 genes, which shows an autosomal dominant pattern of inheritance. Six other genes, CRTAP, LEPRE1, FKBP10, PP1B, SP7/Osterix (OSX), and SERPINH1, are associated with autosomal recessive forms of OI. However, other, rare phenotypes have also been described. There are many differential diagnoses of the short, syndromic child, including chromosomal, single gene, and multifactorial causes. However, one condition of particular relevance in the context of this report is the Russell-Silver syndrome (RSS). As originally described, the RSS is a very specific condition. However, it has subsequently become an umbrella term for a heterogeneous group of conditions presenting with short stature and triangular shape to the face. A significant proportion of these are now believed to be due to imprinting defects at 11p15. However, the cause in many cases remains unknown. We describe two cases with a phenotypic overlap between OI and RSS who both have COL1A1 mutations. Thus, a type 1 collagenopathy should be considered in the differential diagnosis of syndromic short stature.

  16. Heredity, development and evolution: the unmodern synthesis of E.S. Russell.

    Science.gov (United States)

    Esposito, Maurizio

    2013-09-01

    In 1930, while R.A. Fisher, J.B.S. Haldane, E.B. Ford and S.G. Wright were laying the foundations of what a decade later J.S. Huxley dubbed "Modern Synthesis", E.S. Russell published a groundbreaking work, The Interpretation of Development and Heredity. In this book Russell not only condemned Mendelian genetics and neo-Darwinism, but also proposed an alternative synthesis unifying heredity, development, and evolution. The book did not represent the work of a mind operating in isolation. Rather, it was a synthetic work connecting ideas and doctrines of many influential scientists working in Europe and the USA. Through the analysis of archival documents and rarely or never mentioned sources, this article provides an unconventional picture of Russell's theoretical biology. It will be shown that Russell was an international celebrity; he was at the centre of a large network of scholars who shared his ideas and insights. He was one of several biologists arguing for a different synthesis; a synthesis perhaps less visible, less institutionalised, and less 'modern', nevertheless with its influential advocates and international support. Finally, this study shows that Russell's synthesis was not rooted in the classic pantheon of towering figures in the history of biology, i.e. Darwin, Wallace, and Mendel, but was based on the teachings of Kant, Goethe, Cuvier, von Baer, and Müller.

  17. Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom.

    Science.gov (United States)

    Maung, K M; Lynn, Z

    2012-12-01

    Snake bite has been regarded as an important health problem in Myanmar since early 1960's. In the recent years, there has been growing interest in alternative therapies and therapeutic use of natural products, especially those derive from plants. In Myanmar and Indian traditional medicine, various plants have used as a remedy for treating snake bite. The present study was carried out to evaluate the effects of alcohol extract of Tamarind (Tamarindus indica Linn.) seed on some biologic properties of Russell's viper (Daboia russelli siamensis) venom (RVV). The Phospholipase A2 (PLA2) enzyme, coagulase enzyme and caseinolytic enzyme activities of Russell's viper venom (RVV) were reduced when mixed and incubated with the extract. When the RVV and the different amount of extracts were preincubated and injected intramuscularly into mice, all of them survived, but all the mice in the control group died. On the other hand, when RVV were injected first followed by the extract into mice, all of them died. If the extract was injected near the site where Russell's viper venom was injected, all the mice survived for more than 24 hours and the survival time prolonged but they all died within 96 hours. In conclusion, according to the results obtained, the extract neutralizes some biologic properties of the Russell's viper venom and prolonged the survival time if the extract was injected near the site where the Russell's viper venom was injected.

  18. The life and viper of Dr Patrick Russell MD FRS (1727-1805): physician and naturalist.

    Science.gov (United States)

    Hawgood, B J

    1994-11-01

    It is nearly two hundred years since the publication in 1796 of An Account of Indian Serpents collected on the Coast of Coromandel by Patrick Russell. Within the folio is a drawing and description of the venomous snake called Katuka Rekula Poda in the local Telugu language, whose venom was shown experimentally by Dr Russell to be nearly as lethal as that of Cobra de Capello. The snake is now known as Vipera russelli or Russell's viper. Dr Russell was representative of the naturalistic tendency of British medicine in the late 18th century. He was a keen observer and skilled doctor in clinical practice, particularly in Aleppo, Syria, during an outbreak of the plague, and indefatigable in his study of plant and animal life both in Aleppo and later in the Madras Province of India. As a physician as well as Naturalist to the East India Company in the Carnatic he was concerned with the problem of snakebite. His first aim was to find a means whereby the non-specialist could distinguish between poisonous and harmless snakes and so combat the terrible notion that all bites were mortal. His writing, encompassing social and natural histories and climaxed by a study of snakes, has left a rich legacy. Dr Patrick Russell was a man of the highest integrity and ability, a physician and naturalist par excellence.

  19. Russell and Burch's 3Rs then and now: the need for clarity in definition and purpose.

    Science.gov (United States)

    Tannenbaum, Jerrold; Bennett, B Taylor

    2015-03-01

    Russell and Burch's The Principles of Humane Experimental Technique was first published in 1959. A Special Edition containing the original text was reissued in 1992, after its ideas had gained widespread interest in the scientific community. In the Principles, Russell and Burch proposed a new applied science that would improve the treatment of laboratory animals while advancing the quality of science in studies that use animals. They introduced and defined the terms replacement, reduction, and refinement, which subsequently have become known as 'alternatives' or 'alternative methods' for minimizing the potential for animal pain and distress in biomedical research. Here we describe and explain the original definitions of the 3Rs in the Principles, examine how current definitions differ among themselves and from Russell and Burch's definitions, and suggest relevant considerations for evaluating all definitions of the 3Rs.

  20. New developments in Silver-Russell syndrome and implications for clinical practice.

    Science.gov (United States)

    Ishida, Miho

    2016-04-01

    Silver-Russell syndrome is a clinically and genetically heterogeneous disorder, characterized by prenatal and postnatal growth restriction, relative macrocephaly, body asymmetry and characteristic facial features. It is one of the imprinting disorders, which results as a consequence of aberrant imprinted gene expressions. Currently, maternal uniparental disomy of chromosome 7 accounts for approximately 10% of Silver-Russell syndrome cases, while ~50% of patients have hypomethylation at imprinting control region 1 at chromosome 11p15.5 locus, leaving ~40% of cases with unknown etiologies. This review aims to provide a comprehensive list of molecular defects in Silver-Russell syndrome reported to date and to highlight the importance of multiple-loci/tissue testing and trio (both parents and proband) screening. The epigenetic and phenotypic overlaps with other imprinting disorders will also be discussed.

  1. 77 FR 44611 - Russell City Energy Company, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2012-07-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Russell City Energy Company, LLC; Supplemental Notice That Initial Market... in the above-referenced proceeding, of Russell City Energy Company, LLC's application for market...

  2. A new cycle of jökulhlaups at Russell Glacier, Kangerlussuaq, West Greenland

    DEFF Research Database (Denmark)

    Russell, Andrew J.; Carrivick, Jonathan L.; Ingeman-Nielsen, Thomas

    2011-01-01

    Jokulhlaups in 2007 and 2008 from an ice-dammed lake at the northern margin of RussellGlacier, West Greenland, marked the onset of a renewed jokulhlaup cycle after 20 years of stability. Wepresent a record of successive ice-dammed lake drainage events and associated ice-margin dynamicsspanning 25......-based examination of controls on jokulhlaup magnitude and frequency for thissystem. We find that Russell Glacier jokulhlaups have a much higher peak discharge than predicted bythe Clague–Mathews relationship, which we attribute to an unusually short englacial/subglacialrouteway and the presence of a thin ice dam...

  3. Prenatal molecular testing for Beckwith-Wiedemann and Silver-Russell syndromes

    DEFF Research Database (Denmark)

    Eggermann, Thomas; Brioude, Frédéric; Russo, Silvia

    2016-01-01

    Beckwith-Wiedemann and Silver-Russell syndromes (BWS/SRS) are two imprinting disorders (IDs) associated with disturbances of the 11p15.5 chromosomal region. In BWS, epimutations and genomic alterations within 11p15.5 are observed in >70% of patients, whereas in SRS they are observed in about 60...

  4. 75 FR 67095 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, Montana

    Science.gov (United States)

    2010-11-01

    ... Fish and Wildlife Service Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, Montana AGENCY: Fish and Wildlife Service, Interior (DOI). ACTION: Notice; extension of comment period. SUMMARY: We, the U.S. Fish and Wildlife Service, are extending the comment period for...

  5. 75 FR 54381 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT

    Science.gov (United States)

    2010-09-07

    ... Fish and Wildlife Service Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability: Draft...; request for comments. SUMMARY: We, the U.S. Fish and Wildlife Service (Service), announce the...

  6. Researcher Profile: An Interview with Russell James, JD, PhD, CFP(R

    Directory of Open Access Journals (Sweden)

    Russell James

    2014-03-01

    Full Text Available Russell James is a professor and the CH Foundation Chair in Personal Financial Planning in the Department of Personal Financial Planning at Texas Tech University, where he is also the Director of Graduate Studies in Charitable Financial Planning. His research is focused on encouraging generosity and satisfaction in financial decision-making.

  7. 77 FR 67829 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT...

    Science.gov (United States)

    2012-11-14

    .... Montana State University- 1500 University Drive, 406-657-2011 Billings. Billings, MT 59101. Montana State... Refuge, MT; Availability of Record of Decision for the Final Comprehensive Conservation Plan and Final... of the message. U.S. mail: Charles M. Russell NWR, P.O. Box 110, Lewistown, MT 59457....

  8. Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell's Viper Bites with Coagulopathy.

    Directory of Open Access Journals (Sweden)

    Geoffrey K Isbister

    Full Text Available Russell's viper envenoming is a major problem in South Asia and causes venom induced consumption coagulopathy. This study aimed to investigate the kinetics and dynamics of venom and clotting function in Russell's viper envenoming.In a prospective cohort of 146 patients with Russell's viper envenoming, we measured venom concentrations, international normalised ratio [INR], prothrombin time (PT, activated partial thromboplastin time (aPTT, coagulation factors I, II, V, VII, VIII, IX and X, and von Willebrand factor antigen. The median age was 39 y (16-82 y and 111 were male. The median peak INR was 6.8 (interquartile range [IQR]: 3.7 to >13, associated with low fibrinogen [median,3 at 6 h post-antivenom but had reduced to <2, by 24 h. The aPTT had also returned to close to normal (<50 sec at 24 h. Factor VII, VIII and IX levels were unusually high pre-antivenom, median peak concentrations of 393%, 307% and 468% respectively. Pre-antivenom venom concentrations and the INR (r = 0.20, p = 0.02 and aPTT (r = 0.19, p = 0.03 were correlated (non-parametric Spearman analysis.Russell's viper coagulopathy results in prolonged aPTT, INR, low fibrinogen, factors V, VIII and X which recover over 48 h. Severity of clotting abnormalities was associated with venom concentrations.

  9. "Your Tern Now My Tern Later": A Tribute to the Outlaw Writer Russell Hoban

    Science.gov (United States)

    de Rijke, Victoria

    2013-01-01

    Russell Hoban died in December 2011. In this article, Victoria de Rijke celebrates this mysterious writer's huge contribution to children's literature over 52 years; a career which began and ended with two mythological books: "The Mouse & His Child" (1967) and "Soonchild" (2012). Published in "CLE" over…

  10. Visualizing, Rather than Deriving, Russell-Saunders Terms: A Classroom Activity with Quantum Numbers

    Science.gov (United States)

    Coppo, Paolo

    2016-01-01

    A 1 h classroom activity is presented, aimed at consolidating the concepts of microstates and Russell-Saunders energy terms in transition metal atoms and coordination complexes. The unconventional approach, based on logic and intuition rather than rigorous mathematics, is designed to stimulate discussion and enhance familiarity with quantum…

  11. "Adoption Wisdom: A Guide to the Issues and Feelings of Adoption" by Marlou Russell. Book Review.

    Science.gov (United States)

    Simonson, Tracy

    1998-01-01

    Reviews "Adoption Wisdom: A Guide to the Issues and Feelings of Adoption" by Marlou Russell. Maintains that its narrative/comment format and accounts of those involved in adoption validate the feelings of the adoption-triad members. Suggests that the book lacks information on individuals who contributed comments and contains few narratives from…

  12. Narrative report 1970: Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Mason, Yellow Water, War Horse & Wild Horse

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1970 calendar year. The report...

  13. National Wildlife Refuge Visitor Survey 2010/2011 : Individual refuge results for Charles M. Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the National Wildlife Refuge Visitor Survey for Charles M. Russell NWR and is part of the USGS Data Series 643. The survey was conducted to...

  14. [Charles M. Russell National Wildlife Refuge : Sentinel plant species field inventory study plan and methods : Summer 2007

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This study plan is for the assessment and adaptive management of environmental processes with sentinel plant species at Charles M. Russell National Wildlife Refuge....

  15. Narrative report FY 1978 for Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason & War Horse Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell National Wildlife Refuge (including the satellite refuges) outlines Refuge accomplishments during the 1978 calendar...

  16. Narrative report FY 1977 for Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Lake Mason & War Horse Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell National Wildlife Range (including the satellite refuges) outlines Refuge accomplishments during the 1977 calendar year....

  17. Narrative report FY 1974: Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Lake Mason & War Horse Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1974 fiscal year. The report...

  18. Narrative report FY 1975: Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Lake Mason & War Horse Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1975 fiscal year. The report...

  19. Department of the Interior : Draft Environmental Statement : DES 74-54 : Proposed Charles M. Russell National Wildlife Range Wilderness Area

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a draft of an analysis of the environmental impact wilderness designation would pose for the Charles M. Russell National Wildlife Range Wilderness...

  20. Sequencing and analysis of the complete mitochondrial DNA of Russell's snapper (L.russellii)

    Institute of Scientific and Technical Information of China (English)

    Yusong Guo; Zhongduo Wang; Chuwu Liu; Yun Liu

    2008-01-01

    The entire mitochondrial DNA sequence (mitogenome) of Russell's snapper (Lutjanus russellii) was determined using long PCR and primer-walking methodology,representing the first complete mitogenome accessioned for Lutjanid fishes (16,505 bp,GenBank Accession No.EF514208).The mitogenome was similar in gene composition and order to those of other vertebrates,having 37 structural genes,i.e.,two ribosomal RNAs,22 transfer RNAs,and 13 protein-coding genes.Phylogenetic analyses based on the mtDNA sequence of Russell's snapper supported a close relationship between Lutjaninae and Caesioninae,consistent with taxonomic hypotheses based on morphology.More studies utilizing mitogenomes are needed to resolve high-level relationships among snappers.

  1. Bertrand Russell : [poems] / Jaan Kaplinski ; transl. by the author, ed. by Fiona Sampson

    Index Scriptorium Estoniae

    Kaplinski, Jaan, 1941-

    2003-01-01

    Autori lühitutvustus lk. 266. Sisu: Bertrand Russell ; "Once again I think of what I have read..." ; "I do not feel at home in this synthetic world..." ; "Silence is always here and everywhere..." ; "In the morning, I was presented to President Mitterrand..." ; Evening is coming. The land and the forest meet..." ; " A cloudy afternoon in late autumn..." ; "My poems often aren't poems..." ; "My eyesight's weakening...". Orig.: Bertrand Russell ; Mõtlen taas loetule..." ; "Ei ole kodune siin sünteetilises maailmas..." ; "Vaikus on alati siin..." ; "Hommikul tutvustati mind president Mitterrandile.." ; "Õhtu tuleb ja maa ja mets saavad kokku..." ; "Pilvealune südasügise-pärastlõuna..." ; "Mu luuletused ei ole tihti luuletused..." ; "Silmad on nõrgaks jäänd..."

  2. A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies

    Directory of Open Access Journals (Sweden)

    Hidekazu Kayano

    2011-01-01

    Full Text Available A 71-year-old Japanese male patient infected with HCV was diagnosed with thrombocytopenia. Histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with Russell bodies. Immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of CD5+ CD23+ B cells. Russell bodies were positive for IgM and lambda immunoglobulin light chain. The patient also underwent gastric biopsy, which revealed Helicobacter pylori (HP infection. Subsequent eradication of the bacteria resulted in improvement of his thrombocytopenia. The clinical course remained uneventful at 15-month follow-up, consistent with monoclonal B-cell lymphocytosis. The observed clonal expansion with plasmacytic differentiation may have occurred under the influence of HCV with HP infection.

  3. Bertrand Russell : [poems] / Jaan Kaplinski ; transl. by the author, ed. by Fiona Sampson

    Index Scriptorium Estoniae

    Kaplinski, Jaan, 1941-

    2003-01-01

    Autori lühitutvustus lk. 266. Sisu: Bertrand Russell ; "Once again I think of what I have read..." ; "I do not feel at home in this synthetic world..." ; "Silence is always here and everywhere..." ; "In the morning, I was presented to President Mitterrand..." ; Evening is coming. The land and the forest meet..." ; " A cloudy afternoon in late autumn..." ; "My poems often aren't poems..." ; "My eyesight's weakening...". Orig.: Bertrand Russell ; Mõtlen taas loetule..." ; "Ei ole kodune siin sünteetilises maailmas..." ; "Vaikus on alati siin..." ; "Hommikul tutvustati mind president Mitterrandile.." ; "Õhtu tuleb ja maa ja mets saavad kokku..." ; "Pilvealune südasügise-pärastlõuna..." ; "Mu luuletused ei ole tihti luuletused..." ; "Silmad on nõrgaks jäänd..."

  4. Distinct 15q genotypes in Russell-Silver and ring 15 syndromes

    Energy Technology Data Exchange (ETDEWEB)

    Rogan, P.K.; Seip, J.R. [Pennsylvania State Univ., Hershey, PA (United States); Driscoll, D.J. [Univ. of Florida, Gainesville (United States)] [and others

    1996-03-01

    Individuals with a ring 15 chromosome [r(15)] and those with Russell-Silver syndrome have short stature, developmental delay, triangular face, and clinodactyly. To assess whether the apparent phenotypic overlap of these conditions reflects a common genetic cause, the extent of deletions in chromosome 15q was determined in 5 patients with r(15), 1 patient with del 15q26.1-qter, and 5 patients with Russell-Silver syndrome. All patient with Russell-Silver syndrome were diploid for genetic markers in distal 15q, indicating that Russell-Silver syndrome in these individuals was unlikely to be related to the expression of single alleles at these or linked genetic loci. At least 3 distinct sites of chromosome breakage close to the telomere were found in the r(15) and del 15q25.1-qter patients, with 1 r(15) patient having both a terminal and an interstitial deletion. Although the patient with del 15q25.1-qter exhibited the largest deletion and the most profound growth retardation, the degree of growth impairment among the r(15) patients was not correlated with the size of the deleted interval. Rather, the parental origin of the ring chromosome in several patients was associated with phenotypes that are also seen in patients with either Prader-Willi (PWS) or Angelman (AS) syndromes, conditions that result from uniparental expression of genes on chromosome 15. The PWS-like or AS-like phenotypes could be explained by postzygotic loss of the ring chromosome, leading to uniparental inheritance of the intact chromosome in some tissues of r(15) patients. 33 refs., 2 figs., 3 tabs.

  5. Finding the courage: the unconventional lives of WMS and Claire Russell.

    Science.gov (United States)

    Paskal, Cleo

    2009-12-01

    WMS and Claire Russell led lives of extraordinary intellectual adventure, spanning from the traditional formal education of Oxford University to the creativity of science fiction and the experimental world of mid-20th Century psychoanalysis. The verbal and pictorial illustrations presented in this article offer an insight into the vast collection of documents related to their lives and work currently being catalogued in the Manuscripts and Special Collections department of the University of Nottingham.

  6. Memory as acquaintance with the past: some Lessons from Russell, 1912-1914

    Directory of Open Access Journals (Sweden)

    Paulo Faria

    2010-06-01

    Full Text Available Russell's theory of memory as acquaintance with the past seems to square uneasily with his definition of acquaintance as the converse of the relation of presentation of an object to a subject. We show how the two views can be made to cohere under a suitable construal of 'presentation', which has the additional appeal of bringing Russell's theory of memory closer to contemporary views on direct reference and object-dependent thinking than is usually acknowledged. The drawback is that memory as acquaintance with the past falls short of fulfilling Russell's requirement that knowledge by acquaintance be discriminating knowledge - a shortcoming shared by contemporary externalist accounts of knowledge from memory.A teoria russelliana da memória como contato (acquaintance com o passado parece coadunar-se mal com definição do contato (acquaintance como a conversa da relação de apresentação de um objeto a um sujeito. Mostramos como as duas concepções podem ser conciliadas mediante uma interpretação apropriada de 'apresentação', que tem a vantagem adicional de salientar uma proximidade maior que a usualmente reconhecida entre a teoria da memória de Russell e idéias contemporâneas sobre referência direta e pensamentos dependentes de objeto. O preço a pagar é o reconhecimento de que a memória como contato (acquaintance com o passado não satisfaz o requisito russelliano de que o conhecimento por contato deva ser discriminativo - uma limitação que é compartilhada pelas abordagens externalistas contemporâneas do conhecimento derivado da memória.

  7. Russell Reising, 'Every Sound There Is'. The Beatles' Revolver and the Transformation of Rock and Roll

    OpenAIRE

    Etlinger, Sarah A.

    2012-01-01

    Russell Reising declares in the introduction to his excellent collection commemorating Revolver that “Revolver has always been the right answer” (1) to any question concerning the “best” Beatles album of all time. Reising suggests that this album, instead of the more popular and critically acclaimed Sgt. Pepper, is rapidly tightening “its grip on our collective imagination”(1) for it introduces the Beatles as true pioneers of musical experimentation. As a “grandly complex and ambitious statem...

  8. Chronic Pituitary Failure Resembling Sheehan's Syndrome Following a Bite of Russell's Viper. A Case Report.

    Science.gov (United States)

    Srinivasan, K G; Srividya, S; Usha Nandhini, K P; Ramprabananth, S

    2010-03-01

    Hypopituitarism can be the sequela of a variety of causes like postpartum pituitary necrosis or Sheehan's syndrome, lymphocytic hypophysitis, trauma and encephalitis. A very rare cause is envenomation by a bite of a Russell's viper. Very few cases with documented imaging findings of chronic pituitary failure resulting from snake bite have been reported. We describe a case of hypopituitarism with clinical, endocrine and magnetic resonance (MR) imaging studies occurring as a delayed complication of snake bite.

  9. Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a Jack Russell terrier

    OpenAIRE

    JO'Neill Emma; Acke Els; Tobin Emma; McCarthy Grainne

    2010-01-01

    Abstract A twenty-month-old Jack Russell terrier was presented with a four-day history of thrombocytopenia, echymotic inguinal haemorrhages, coughing and reduced exercise tolerance. Clinical examination revealed several petechial haemorrhages on the gingivae and small echymotic haemorrhages in the inguinal region, along with mild bilateral epistaxis. Haematology confirmed a platelet count of 1.0 × 10/L. Thoracic radiographs revealed a wide-spread mixed alveolar-interstitial lung pattern, appa...

  10. Charles Robert Darwin and Alfred Russel Wallace: their dispute over the units of selection.

    Science.gov (United States)

    Ruse, Michael

    2013-12-01

    Charles Darwin and Alfred Russel Wallace independently discovered the mechanism of natural selection for evolutionary change. However, they viewed the working of selection differently. For Darwin, selection was always focused on the benefit for the individual. For Wallace, selection was as much something of benefit for the group as for the individual. This difference is traced to their different background political-economic views, with Darwin in favor of Adam Smith's view of society and Wallace following Robert Owen in being a socialist.

  11. Congenital deafness in Jack Russell terriers: prevalence and association with phenotype.

    Science.gov (United States)

    Comito, B; Knowles, K E; Strain, G M

    2012-08-01

    Congenital hereditary sensorineural deafness is the most common form of deafness in dogs. The objectives of this study were to determine a reliable measure of the prevalence of deafness in Jack Russell terriers, an affected breed, and associations between deafness and phenotypic characteristics. Brainstem auditory evoked response recordings and phenotypic parameters (coat color, coat texture, sex, eye color, sire and dam hearing status) were recorded for 1009 Jack Russell terriers. The prevalence of unilateral and bilateral deafness was 3.57% and 0.50%, respectively, lower by a factor of three to four than in earlier reports based on smaller and closely related kindreds. Significant association with deafness was identified with white coat color and parental hearing status, but not with sex or coat type. Lack of significant sex or coat type associations and the significant association with white coat color are consistent with previous reports. In conclusion the prevalence of deafness in Jack Russell terriers is lower than initially reported. Deafness was associated with white coat color and parental hearing status. The association with parental hearing status supports this form of deafness being a heritable trait in the breed and the association with white coat color supports an inheritance linked to pigmentation genes.

  12. A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.

    Science.gov (United States)

    Rohdin, Cecilia; Gilliam, Douglas; O'Leary, Caroline A; O'Brien, Dennis P; Coates, Joan R; Johnson, Gary S; Jäderlund, Karin Hultin

    2015-05-23

    Hereditary ataxias with similar phenotypes were reported in the Smooth-Haired Fox Terrier, the Jack Russell Terrier and the Parson Russell Terrier. However, segregation analyses showed differing inheritance modes in these breeds. Recently, molecular genetic studies on the Russell group of terriers found independent mutations in KCNJ10 and CAPN1, each associated with a specific clinical subtype of inherited ataxia. The aim of this study was to clarify whether or not Smooth-Haired Fox Terriers with hereditary ataxia and dogs of other related breeds harbor either of the same mutations. A sub goal was to update the results of KCNJ10 genotyping in Russell group terriers. Three Smooth-Haired Fox Terriers with hereditary ataxia and two Toy Fox Terriers with a similar phenotype were all homozygous for the KCNJ10 mutation. The same mutation was also found in a heterozygous state in clinically unaffected Tenterfield Terriers (n = 5) and, in agreement with previous studies, in Jack Russell Terriers, Parson Russell Terriers, and Russell Terriers. A KCNJ10 mutation, previously associated with an autosomal recessive spinocerebellar ataxia in Jack Russell Terriers, Parson Russell Terriers, and Russell Terriers segregates in at least three more breeds descended from British hunting terriers. Ataxic members of two of these breeds, the Smooth-Haired Fox Terrier and the Toy Fox Terrier, were homozygous for the mutation, strengthening the likelihood that this genetic defect is indeed the causative mutation for the disease known as "hereditary ataxia" in Fox Terriers and "spinocerebellar ataxia with myokymia, seizures or both" in the Russell group of terriers.

  13. A petition to Mr Peel: Gideon Mantell and the trial of Hannah Russell.

    Science.gov (United States)

    Flanagan, R J; Watson, K D

    2009-07-01

    In the summer of 1826, Hannah Russell was tried for petty treason, viz. the murder of her husband, Benjamin Russell, by poisoning. Their lodger, Daniel Leney, was indicted as her accomplice. The exact circumstances surrounding the death were unclear but Hannah was known to have purchased white arsenic (arsenious oxide). A local surgeon, Thomas Evans, supported at the post-mortem examination by two further surgeons, not only reported severe corrosion of the gastrointestinal tract, but also the recovery of nearly an eighth of an ounce of arsenic from the victim's stomach. Both accused were convicted and sentenced to death. Leney was executed, but Hannah Russell was respited because the trial judge, Sir Robert Graham, had doubts as to a direction he had given to the jury. The surgeon and paleontologist Gideon Mantell took up her case, stressing that death from arsenic could not have taken place as quickly as was alleged and maintaining that the chemical evidence of arsenic poisoning was inconclusive. He gained the support of some eminent chemists and physicians. Subsequently, forensic toxicologists [Sir] Robert Christison and Alfred Swaine Taylor pointed out that Mantell's arguments as to the possible time to death in arsenic poisoning were quite wrong. Moreover, Evans gave details of the analyses he and his colleagues had undertaken to Christison, who pronounced the findings sound, as indeed did Mantell after Evans and his colleagues published details of their investigations in the Sussex Advertiser. Papers in The National Archives show that Hannah was pardoned for the offence for which she was indicted, leaving it open to prefer a lesser charge. That this was never done may have been due to Mantell's campaign, at least in part, but the pardon she did receive was due to the concern of the trial judge as to the implications of the evidence presented at trial.

  14. 股骨近端防旋髓内钉治疗 Russell-TaylorⅡ型股骨转子下骨折%Proximal femoral nail antirotation in Russell-TaylorⅡtype femoral subtrochanteric fracture

    Institute of Scientific and Technical Information of China (English)

    孟位明; 许红生; 付卫杰; 王平

    2014-01-01

    目的:探讨股骨近端防旋髓内钉(PFNA)治疗Russell-TaylorⅡ型股骨转子下骨折的手术方法及疗效。方法对17例Russell-TaylorⅡ型股骨转子下骨折患者牵引复位后均行PFNA内固定治疗。结果手术时间60~90 min,术中出血量150~400 ml。17例均获随访,时间10~24个月。骨折均达骨性愈合。按Harris标准进行髋关节功能评价:优10例,良6例,可1例。结论 PFNA治疗Russell-TaylorⅡ型股骨转子下骨折操作简单,创伤小,疗效满意。%Objective To explore the surgical methods and therapeutic effect of the proximal femoral nail antirotation (PFNA)in treatment Russell-TaylorⅡ type femoral subtrochanteric fractures.Methods The PFNA were used for internal fixation in 17 patients of Russell-Taylor Ⅱ type femoral subtrochanteric fractures.Results The operation time was 60~90 minutes,and intraoperative blood loss was 150~400 ml.All 17 patients were followed up for 10~24 months.The fracture of all patients achieved bony healing.According to the standard of Harris hip joint function assessment,the results were excellent in 10 patients,good in 6 and fair in 1.Conclusions PFNA treatment is sim-ple to be used in Russell-TaylorⅡtype femoral subtrochanteric fractures with minimal trauma,and curative effect is satisfied.

  15. Right cranial lung lobe torsion after a diaphragmatic rupture repair in a Jack Russell terrier

    Directory of Open Access Journals (Sweden)

    Terzo E

    2008-03-01

    Full Text Available Abstract A seven-year-old male Jack Russell terrier was presented with a history of coughing, generalised weakness and lethargy 10 days after an abdominal coeliotomy to repair a large diaphragmatic rupture. Thoracic radiographs demonstrated a soft tissue mass in the midcaudal right thoracic cavity. Ultrasonographic studies, bronchoscopy and subsequent exploratory thoracotomy confirmed a diagnosis of a right cranial lung lobe torsion (LLT, with an anomalous caudodorsal displacement of the affected lobe. LLT should be considered as a differential diagnosis for respiratory tract disease following diaphragmatic rupture repair.

  16. Psychosis in secondary empty sella syndrome following a Russell's viper bite

    Directory of Open Access Journals (Sweden)

    Badr Ratnakaran

    2016-01-01

    Full Text Available Hypopituitarism can present with psychiatric symptoms. We report a unique case of psychosis in clear consciousness in a case of hypopituitarism due to the secondary empty sella syndrome following a Russell's viper bite which was untreated and presented with psychotic symptoms for past 13 years following the snake bite. After the diagnosis of psychosis due to hypopituitarism was made, the patient was treated with levothyroxine and prednisolone supplements and his psychotic symptoms subsided without any psychotropic drugs. Vasculotoxic snake bites can cause hypopituitarism and can present with psychosis. Further research will be needed into the prevalence of this phenomenon.

  17. Seminoma in a Man with Russell-Silver Syndrome Presenting with Testicular Torsion

    Directory of Open Access Journals (Sweden)

    Satoshi Funada

    2016-01-01

    Full Text Available Russell-Silver syndrome (RSS is a type of primordial dwarfism. Only one case of testicular cancer in RSS has been reported, the pathology of which was nonseminoma. Here, we report a case of seminoma in a 36-year-old man who was diagnosed with RSS at birth. The seminoma was diagnosed when the patient presented with testicular torsion. This is the first report of testicular seminoma in an RSS patient in the literature. We also discussed the correlation between seminoma and RSS.

  18. Herpes labialis in patients with Russell's viper bite and acute kidney injury: a single center experience.

    Science.gov (United States)

    Waikhom, Rajesh; Sapam, Ranjeeta; Patil, Krishna; Jadhav, Jaya Prada; Sircar, Dipankar; Roychowdhury, Arpita; Dasgupta, Sanjay; Pandey, Rajendra

    2011-06-01

    Snake bite is an important health hazard in tropical countries and is associated with significant morbidity and mortality. Herpes labialis is a common ailment caused by the Herpes simplex virus. There is no published data showing any association between the snake bite and development of Herpes labialis. Here, we present a series of patients who developed Herpes labialis after Russell's viper bite and had acute kidney injury. We attempted to find whether snake bite is an immunosuppressed state and whether it could have pre-disposed the patients to the development of these lesions.

  19. Novel role of antiplatelet agents (aspirin plus clopidogrel in an incoagulable blood of a victim of russell's viper snakebite

    Directory of Open Access Journals (Sweden)

    H. S. Bawaskar

    2006-01-01

    Full Text Available Snake antivenom is a specific antidote to the venom action, neutralizing the circulating venom. However, it fails to neutralize the venom fixed to target organs such as platelets, renal tubules, etc. Russell's viper venom initiates rapid coagulation in a victim by activating blood platelets, factors V, X, and anticoagulant cofactors. Activation of thrombin, resulting in formation of micro-thrombi, fibrinolysis, and a vicious cascade, sets in. Inhibition of activated platelets by aspirin (cyclooxygenase inhibitor and clopidogrel (ADP receptor inhibitor helps to break this vicious circle induced by Russell's venom and may initiate the natural physiological clotting mechanism. They can be utilized as an adjuvant treatment.

  20. Role of Russell - Taylor delta reconstruction nail in the management of complex proximal femoral fractures

    Directory of Open Access Journals (Sweden)

    Raj D

    2005-01-01

    Full Text Available Background: Complex proximal femoral fractures are challenging problem. Methods: Forty-one patients had Russell- Taylor Delta reconstruction nailing done during the period from March 1992 to December 1996. 38 patients could be followed both clinically and radiologically either up to the fracture union or death. Clinical outcome was assessed by Kyle′s criteria. Out of 13 patients with high-energy comminuted fractures, 12 were rated excellent or good. There was one death due to poly trauma. Results: Out of six elderly subtrochanteric fractures, 4 had excellent or good results. There was one poor result and one death. Out of 11 elderly interochanteric fractures with subtrochanteric extension, 8 had excellent or good results. There was 1 fair, 1 poor result and 1 death. In the elderly groups, the poor results were due to poor pre- existing medical conditions of the patients. In all the seven cases of pathological lesions, excellent or good results were achieved either till fracture union or death because of their malignant pathology. Conclusion: Russell- Taylor Delta reconstruction nail is a very useful device in high-energy comminuted proximal femoral fractures, in elderly low energy proximal femoral fractures and also in pathological lesions. The implant provides bio-mechanically stable fixation. The relatively high complication rate in elderly patients is because of their poor medical condition. In cases of pathological lesions, it is always preferable to fix the bone at the stage of impending fracture.

  1. W. Ritchie Russell, A.B. Baker, and Fred Plum: Pioneers of ventilatory management in poliomyelitis.

    Science.gov (United States)

    Wijdicks, Eelco F M

    2016-09-13

    Historically, neurologists were not involved in the day-to-day management of critically ill patients with bulbar poliomyelitis, but some were. The major contributions of 3 neurologists-W. Ritchie Russell, A.B. Baker, and Fred Plum-in the respiratory management of poliomyelitis have not been recognized. Russell's work was instrumental in identifying multiple types of poliomyelitis defined by their respiratory needs, and he advised treatment that varied from simple postural drainage to use of respirators. He participated in the development of the Radcliffe respiratory pump. Baker recognized the essential involvement of the vagal nerve in respiratory distress, but also observed that involvement of vital centers without cranial nerve involvement would lead to irregular and shallow respiration in some patients and in others with marked dysautonomic features. A similar finding of central involvement of respiration was noted by Plum, who also stressed the importance of hypercapnia. Plum emphasized measurements of vital capacity and techniques to minimize trauma with suctioning after tracheostomy. These 3 neurologists understood the importance of airway and ventilator management, which is currently one of the many pillars of neurocritical care. © 2016 American Academy of Neurology.

  2. Multiple segmental uniparental disomy associated with abnormal DNA methylation of imprinted loci in Silver-Russell syndrome

    NARCIS (Netherlands)

    R.P. Dias (Renuka); I. Bogdarina (Irina); J.-B. Cazier (Jean-Baptiste); C. Buchanan (Charles); M.C. Donaldson (Magruder); L. Johnston (Linda); A.C.S. Hokken-Koelega (Anita); A.J. Clark (Adrian)

    2012-01-01

    textabstractBackground: Silver-Russell syndrome (SRS; online inheritance in man 180860) is a low-birth-weight syndrome characterized by postnatal growth restriction and variable dysmorphic features. Although maternal uniparental disomy (UPD) of chromosome 7 and hypomethylation of H19 have been repor

  3. Pathogenicity, Ovicidal Action, and Median Lethal Concentrations (LC 50 ) of Entomopathogenic Fungi against Exotic Spiralling Whitefly, Aleurodicus dispersus Russell

    OpenAIRE

    Boopathi Thangavel; Karuppuchamy Palaniappan; Kalyanasundaram Manickavasagam Pillai; Mohankumar Subbarayalu; Ravi Madhaiyan

    2013-01-01

    Biological control using entomopathogenic fungi could be a promising alternative to chemical control. Entomopathogenic fungi, Beauveria bassiana (Balsamo) Vuillemin, Metarhizium anisopliae (Metschnikoff) Sorokin, Lecanicillium lecanii (Zimmerm.) Zare and Gams, and Paecilomyces fumosoroseus (Wize) Brown and Smith, were tested for their pathogenicity, ovicidal effect, and median lethal concentrations (LC50) against exotic spiralling whitefly, Aleurodicus dispersus Russell. The applications were...

  4. Developing a Hybrid Model of Rational-Emotive Therapy and Systemic Family Therapy: A Response to Russell and Morrill.

    Science.gov (United States)

    Guterman, Jeffrey T.

    1991-01-01

    Challenges Russell and Morrill's (1989) assertion that a practical blending of Rational Emotive Therapy (RET) and systemic family therapy is possible. Cautions that a connection between these approaches be made only with an appreciation and respect for these schools' epistemological differences and correspondingly disparate cognitive change…

  5. Síndrome de Russel ou síndrome de Diencefálica de emagreciemento

    Directory of Open Access Journals (Sweden)

    Nelson Pires Ferreira

    1971-06-01

    Full Text Available Os autores relatam um caso de síndrome de Russel ou síndrome diencefálica do emagrecimento. Revisam a literatura disponível sobre o assunto e comentam a dificuldade do diagnóstico na fase inicial da doença.

  6. Algal communities in cryoconite holes on the Russell glacier, Southwest Greenland

    Science.gov (United States)

    Lamsters, Kristaps; Stivrins, Normunds; Karušs, Jānis; Krievāns, Māris; Rečs, Agnis

    2017-04-01

    The surface of the Greenland Ice Sheet in ablation zone has considerably darkened in the last decades, thus absorbing more solar radiation and accelerating ice melting. Darkening of glacier is made of different impurities that reduce surface albedo. These impurities are represented as cryoconite - combination of dust, soot and microorganisms. While mineral dust composes the greatest part of cryoconite, the black carbon is the most solar radiation absorbing constituent. Microorganisms on the ice are concentrated in cryoconite holes, which have long been of scientific interest, but still remain poorly understood. In order to investigate the microbial communities in cryoconite holes, we collected 12 samples from cryoconite holes at 6 sites located on a 2.5 km long transect line on Russell glacier, Southwest Greenland. The first sampling site was set 3 km from glacier margin at 552 m a.s.l. and the last sampling site was 500 m from the glacier margin at 423 m a.s.l. Depth and diameter of each cryoconite hole, as well as pH, temperature and electrical conductivity was measured in situ on July 29, 2017. During microscopic analysis all microcharcoal (10-100 µm), spheroidal carbonaceous particles (soot), pollen, spores and algae were recorded. Principal Component Analysis reveal two clusters of cryoconite holes (located at 423-465 m a.s.l. and 465-552 m a.s.l.) indicating altitudinal differences. Further, our results show that the biomass of green algae Mesotaeniaceae is correlated with temperature. Meanwhile green algae Chlamydomonadaceae correlates with temperature, microcharcoal and soot particle abundance. Our results show that green algae are dominant type of microorganisms inhabiting cryconite holes on the Russell's glacier at least up to distance of 3 km from ice margin. It is contrary to the previous study of Uetake et al. (2010), who found that cyanobacterial (Oscillatoriaceae) community dominated at 510-635 m altitude of the ablation area of Russell glacier in

  7. Possible seasonal activity of gullies on an sand dune (Russell crater, Mars)

    Science.gov (United States)

    Jouannic, Gwénaël.; Gargani, Julien; Costard, François

    2010-05-01

    Recent work has shown that gullies are among the most youthful features on Mars (Malin and Edgett, 2000; Costard et al., 2002; Reiss and Jaumann, 2003, Malin et al., 2006). Here we show that the gullies located on the Russell Crater dune are not only extremely youthful but also seem to be still actives. Various geomorphological features consistent with a seasonal activity suggest reactivated flows over the last three terrestrial years. Moreover, using an assemblage of 26 HiRISE images over a 31 month period (November 2006-May 2009) and superposed with MOLA tracks, we performed a quantitative analysis of the sinuosity and branching of the gullies on the shallow slope of the Russell crater. These geomorphologicals features suggest that debris flow have been formed by a fluid flow. As pure water generally is not thought to be stable on the surface of Mars under current conditions, these gullies could be indicative of a highly localized zone of meta-stability heretofore unidentified in the literature or by a highly mineralized water. Equally, the occurrence of the gullies on a dune may point to a near-surface source, i.e. near surface permafrost (Vedie et al. 2008), that could have been emplaced under conditions associated with late Amazonian obliquity excursions (Costard et al., 2002). Nevertheless, the precise composition of the fluid (CO2, mineralized water,…) is still unknown. Costard, F., Forget, F., Mangold, N., Peulvast, J.P., 2002. Formation of recent martian debris flow by melting of near-surface ground ice at high obliquity. Science, 295, 110-113. Malin, M.C., Edgett, K.E., 2000. Evidence for recent groundwater seepage and surface runoff on Mars. Science, 288, 2330-2335. Malin, M.C., Edgett, K.E., Posiolova, L.V., McColley, S.M., Dobrea, E.Z., 2006. Present day impact crater rate and contemporary gully activity on Mars. Science, 314, 1573-1577. Reiss, D., Jaumann, R., 2003. Recent debris flows on Mars : Seasonal observations of the Russell Crater dune field

  8. FPGA-based adaptive backstepping fuzzy control for a micro-positioning Scott-Russell mechanism

    Science.gov (United States)

    Fung, Rong-Fong; Weng, Ming-Hong; Kung, Ying-Shieh

    2009-11-01

    This paper utilizes the field programmable gate array (FPGA) and Nios II embedded processor technologies to design a controller IC for a micro-positioning Scott-Russell (SR) mechanism, which is driven by a piezoelectric actuator (PA) and its hysteresis phenomenon is described by Bouc-Wen hysteresis model. For the controller design, the adaptive backstepping fuzzy control (ABFC) method is developed to compensate the PA's hysteresis and achieve the motion tracking control. The fuzzy logic method (FLM) is utilized to find the best adaptation gain of the adaptation law and control gain of the stabilization controls. This ABFC controller method can improve the transient and asymptotic tracking performances, and make the SR mechanism keep good working performance when external disturbances is added in the control system. Finally, we successfully apply the system-on-a-programmable-chip (SoPC) technologies to develop the motion controller IC, and achieve the advantages of reduced space, high performance and low cost.

  9. Russell-Silver Syndrome: A Case Report with Review of Literature

    Directory of Open Access Journals (Sweden)

    Sreedevi

    2011-01-01

    Full Text Available Russell-Silver syndrome is a disorder present at birth characterized by low birth weight, poor postnatal growth, craniofacial disproportion, clinodactyly, normal intelligence, downward curvature of the corner of the mouth, syndactyly, cafe-au-fait spots, cryptorchidism. etc. Episodes of hypoglycemia is an important feature in the diagnosis of RSS. Diagnosis of RSS remains clinical as no definite etiology or specific test has been established. It appears to be sporadic in most instances and has been noted to occur in all racial groups. We report to you one such case of an 11-year-old boy who presented with most of the features mentioned above. Early diagnosis of such cases is essential to overcome the psychological trauma to the patient.

  10. Alfred Russel Wallace's medical libertarianism: state medicine, human progress, and evolutionary purpose.

    Science.gov (United States)

    Flannery, Michael A

    2015-01-01

    Alfred Russel Wallace (1823-1913), naturalist and explorer of South America and the Malay Archipelago, secured his place in history by independently discovering the theory of natural selection. His letter outlining the theory was sent from Ternate in eastern Indonesia and received at Down House, according to Charles Darwin (1809-82), on June 18, 1858, prompting the now-famed evolutionist to rush his languishing manuscript to press. Wallace's contributions to evolutionary biology, biogeography, and anthropology are well known, but his medical views have received far less attention. Within the context of a strident populist antivaccination movement and an ominous elitist eugenics campaign, Wallace took his stand, which revealed itself in a libertarianism that defended traditional socialist constituencies (the working poor, the lumpenproletariat, and feminist reformers) against state-mandated medical interventions. Rather than viewing Wallace as a heterodox contrarian, this article argues that his positions were logical outgrowths of his medical libertarianism and evolutionary and social theories.

  11. A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris.

    Science.gov (United States)

    Galli-Tsinopoulou, Assimina; Emmanouilidou, Eleftheria; Karagianni, Paraskevi; Grigoriadou, Maria; Kirkos, John; Varlamis, George S

    2008-01-01

    Silver Russell Syndrome (SRS) is a rare condition (1/3000 - 1/100,000 newborns). We present a female infant with SRS, cardiac malposition and asymmetric enlargement of the clitoris. She is the first child of Greek nonconsanguinous parents, born at 38 weeks gestation, following in vitro fertilisation (IVF). The patient had intrauterine growth retardation, body asymmetry, enlarged clitoris, hemihypertrophy of external genitalia and features characteristic of SRS. Electrocardiography and chest X-rays revealed a median position of the heart. The infant fulfilled the criteria proposed by Price et al for SRS. Genetic analysis did not reveal mUPD of chromosome 7. This is the first report of a patient with SRS presenting ìmesocardiaî and asymmetric enlargement of the clitoris. Our case constitutes another paradigm of SRS following IVF, which possibly supports the hypothesis that IVF may be associated with higher prevalence of SRS than natural fertilisation.

  12. Capturing the will: Imposture, delusion, and exposure in Alfred Russel Wallace's defence of spirit photography.

    Science.gov (United States)

    Mitchell, Benjamin David

    2014-06-01

    The co-discoverer of natural selection, Alfred Russel Wallace, found himself deeply embroiled in a range of controversies surrounding the relationship between science and spiritualism. At the heart of these controversies lay a crisis of evidence in cases of delusion or imposture. He had the chance to observe the many epistemic impasses brought about by this crisis while participating in the trial of the American medium Henry Slade, and through his exchanges with the physiologist William Benjamin Carpenter and the psychical researcher Frederic Myers. These contexts help to explain the increasing value that Wallace placed on the evidence of spirit photography. He hoped that it could simultaneously break these impasses, while answering once and for all the interconnected questions of the unity of the psyche and the reliability of human observation.

  13. Syndrome de Silver Russell: à propos de 3 cas et revue de la litterature

    OpenAIRE

    2013-01-01

    Le syndrome de Silver Russell (SSR) est une maladie génétique rare. Sa prévalence est estimée à 1/100.000. Il s’agit d’une pathologie de l’empreinte parentale, caractérisée par une grande diversité phénotypique. Ses signes cliniques majeurs sont: un retard de croissance intra-utérin sévère, un retard staturo-pondéral post natal, une dysmorphie cranio-faciale particulière et une asymétrie des membres. Nous rapportons dans ce travail les observations de trois patients, qui présentent un retard ...

  14. Syndrome de Silver Russell: à propos de 3 cas et revue de la litterature

    Science.gov (United States)

    Lamzouri, Afaf; Ratbi, Ilham; Sefiani, Abdelaziz

    2013-01-01

    Le syndrome de Silver Russell (SSR) est une maladie génétique rare. Sa prévalence est estimée à 1/100.000. Il s’agit d’une pathologie de l’empreinte parentale, caractérisée par une grande diversité phénotypique. Ses signes cliniques majeurs sont: un retard de croissance intra-utérin sévère, un retard staturo-pondéral post natal, une dysmorphie cranio-faciale particulière et une asymétrie des membres. Nous rapportons dans ce travail les observations de trois patients, qui présentent un retard staturo-pondéral, une dysmorphie faciale caractéristique du SSR et une hemihypertrophie corporelle. Nous discutons à travers ces cas les aspects cliniques et génétiques de ce rare syndrome. PMID:23717707

  15. Sense data and the philosophy of mind: Russell, James, and Mach

    Directory of Open Access Journals (Sweden)

    Gary Hatfield

    2002-12-01

    Full Text Available The theory of knowledge in early twentieth-century Anglo American philosophy was oriented toward phenomenally described cognition There was a healthy respect for the mind body problem, which meant that phenomena in both the mental and physical domain were taken sinuously Bertrand Russell's developing position on sense-data and momentary particulars drew upon, and ultimately became like, the neutral monism of Ernst Mach and William James Due to a more recent behaviorist and physicalist inspired "fear of the mental", this development has been down played in historical work on early analytic philosophy Such neglect as sumes that the "linguistic turn" is a proper and permanent effect of twentieth century philosophy, an assumption that distorts early analytic historiography, and begs a substantive philosophical question about thought and cognition.

  16. Long term evolution of the subglacial water pressure on Russell glacier, a modelling approach.

    Science.gov (United States)

    de Fleurian, Basile; Mouginot, Jeremie; Nisancioglu, Kerim H.

    2017-04-01

    Basal sliding is the main control on land terminating outlet glaciers velocity. This sliding is mainly driven by the water pressure at the base of the glaciers. The ongoing increase in surface melt of the Greenland Ice Sheet warrants an examination of its impact on basal water pressure and in turn on basal sliding. Here, we examine the case of Russell glacier, West Greenland, where a remarkably extensive set of observations have been gathered. Our recently published study (de Fleurian et. al. 2016) is pointing to the fact that two different hydrological regimes exist under this glacier. Near the front of the glacier, the development of an efficient drainage system allows the water pressure to drop quickly at the end of summer and yields a stagnation of its annual-mean value. Conversely, further upglacier, the lack of an efficient drainage system leads to an increase of the mean annual water pressure throughout the years. This study left the question of the long term evolution of the subglacial hydrological system under a warmer climate. To answer this question we present here the results of longer simulations where runoff forcing is derived from a simple Positive Degree Day scheme scaled on the IPCC climatic scenarios. To get further insight from our subglacial hydrological model, we investigate the impact of the varying water pressure on modelled surface velocities. Reference: de Fleurian, B., M. Morlighem, H. Seroussi, E. Rignot, M. R. van den Broecke, P. Kuipers Munneke, J. Mouginot, C. J. P. P. Smeets, and A. J. Tedstone (2016), A modeling study of the effect of runoff variability on the effective pressure beneath Russell Glacier, West Greenland, J. Geophys. Res. Earth Surf., 121, 1834-1848, doi:10.1002/2016JF003842.

  17. The search for mathematical roots, 1870-1940 logics, set theories and the foundations of mathematics from Cantor through Russell to Godel

    CERN Document Server

    Grattan-Guinness, I

    2001-01-01

    While many books have been written about Bertrand Russell's philosophy and some on his logic, I. Grattan-Guinness has written the first comprehensive history of the mathematical background, content, and impact of the mathematical logic and philosophy of mathematics that Russell developed with A. N. Whitehead in their Principia mathematica (1910-1913).This definitive history of a critical period in mathematics includes detailed accounts of the two principal influences upon Russell around 1900: the set theory of Cantor and the mathematical logic of Peano and his followers. Substantial surveys ar

  18. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1990 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  19. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1994 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  20. Narrative report 1972: Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Lake Mason, Yellow Water, War Horse, & Wild Horse Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1972 calendar year. The report...

  1. Developing a protocol to monitor management effects on priority resources in sage steppe habitat at Charles M. Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In 2015, Charles M. Russell National Wildlife Refuge (CMR) received funds from the United States Fish and Wildlife Service (USFWS) Region 6 Inventory and Monitoring...

  2. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1992 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  3. Narrative report 1969: Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Mason, Yellow Water, War Horse & Wild Horse National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1969 calendar year. The report...

  4. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1993 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  5. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1995 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  6. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1997 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  7. Narrative report 1968: Charles M. Russell National Wildlife Range and Hailstone*, Halfbreed*, Mason*, Miller*, Yellow Water*, War Horse*, & Wild Horse* National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR (including the satellite refuges) outlines Refuge accomplishments during the 1968 calendar year. The report...

  8. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1996 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  9. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1998 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  10. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1989 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  11. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1991 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  12. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management District: 1986 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and WarHorse National Wildlife Refuges; the CMR Wetland Management...

  13. Narrative report: Calendar year 1976: Charles M. Russell National Wildlife Range and Hailstone, Halfbreed, Lake Mason & War Horse National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell National Wildlife Range (including the satellite refuges) outlines Refuge accomplishments during the 1976 calendar year....

  14. Movements, distribution and habitat selection of elk in the Missouri River Breaks and portions of the Charles M. Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final report for a study at Charles M. Russell National Wildlife Refuge (CMR) to spatially depict elk habitat use and intensity for a better understanding of elk...

  15. Bird species composition and abundance in two riparian areas with differing grazing histories on the Charles M. Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This paper reports the results of a breeding bird survey conducted in June 1994 in Siparyann Creek drainage and Rock Creek drainage within Charles M. Russell...

  16. Final Comprehensive Conservation Plan and Environmental Impact Statement: Charles M. Russell National Wildlife Refuge, UL Bend National Wildlife Refuge: Volumes 1 and 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Charles M. Russell NWR and UL Bend NWR for the next 15 years. This plan outlines the...

  17. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1999 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  18. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management District: 1987 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and WarHorse National Wildlife Refuges; the CMR Wetland Management...

  19. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 2000 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  20. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 1988 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and WarHorse National Wildlife Refuges; the CMR Wetland Management...

  1. Charles M. Russell National Wildlife Refuge and Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges and the CMR Wetland Management Districts: 2001 annual narrative reports

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Charles M. Russell NWR; Hailstone, Halfbreed, Lake Mason, and War Horse National Wildlife Refuges; the CMR Wetland Management...

  2. Comment on 'Intercalibration of solar wind instruments during the International Magnetospheric Study' by S. M. Petrinec and C. T. Russell

    Science.gov (United States)

    Paularena, K. I.; Lazarus, A. J.

    1994-01-01

    In their paper Petrinec and Russell (PR) (1993) claim to have developed a 'more homogeneous and accurate set of solar wind data' by 'correcting' the reported ion densities from three plasma instruments: the Los Alamos National Laboratory (LANL) ion electrostatic analyzer on ISEE 3 and the LANL electrostatic analyzer and the Massachusetts Institute of Technology (MIT) Faraday cup plasma instrument on Interplanetary Monitoring Platform 8 (IMP 8). Their data manipulation techniques are examined. The foundations on which their data set are built, are discussed. Reanalysis by MIT on the MIT instrument (IMP 8) was done. Initial results have been issued. The Petrinec & Russell (1993) (PR) paper does not provide accurate density estimates and is an exercise that will only bring confusion to users of the data. The results of PR should be treated with skepticism.

  3. Helicobacter pylori-negative Russell body gastritis: does the diagnosis call for screening for plasmacytic malignancies, especially multiple myeloma?

    OpenAIRE

    2014-01-01

    Russell body gastritis (RBG) is a rare entity with unestablished pathophysiology, endoscopic findings, clinical manifestations and treatments. Literature is scarce on this clinical entity with unclear clinical significance. Of 18 cases reported, 12 tested (+) for Helicobacter pylori and improved with treatment, but it remains unclear whether this link is coincidental or bears some clinical significance. We describe a case of elderly woman who had a follow-up oesophagogastroduodenoscopy for ch...

  4. The prominent absence of Alfred Russel Wallace at the Darwin anniversaries in Germany in 1909, 1959 and 2009.

    Science.gov (United States)

    Hossfeld, Uwe; Olsson, Lennart

    2013-12-01

    It is well known that the contribution of Alfred Russell Wallace (1823-1913) to the development of the "Darwinian" principle of natural selection has often been neglected. Here we focus on how the three anniversaries to celebrate the origin of the Darwin-Wallace theory in Germany in 1909, in 1959 in the divided country, as well as in 2009, have represented Charles Robert Darwin's and Alfred Russell Wallace's contributions. We have analyzed books and proceedings volumes related to these anniversaries, and the main result is that Wallace was almost always ignored, or only mentioned in passing. In 1909, Ernst Haeckel gave a talk in Jena, later published under the title The worldview of Darwin and Lamarck (Das Weltbild von Darwin und Lamarck), but not as the Darwin-Wallace concept. Haeckel mentions Wallace only once. In two important proceedings volumes from the 1959 anniversaries, Wallace was ignored. The only fair treatment of Wallace is given in another book, a collection of documents edited by Gerhard Heberer, for which the author selected nine key documents and reprinted excerpts (1959). Three of them were articles by Wallace, including the Sarawak- and Ternate-papers of 1855 and 1858, respectively. An analysis of the dominant themes during the celebrations of 2009 shows that none of the six topics had much to do with Wallace and his work. Thus, the tendency to exclude Alfred Russell Wallace is an international phenomenon, and largely attributable to the "Darwin industry".

  5. Joseph A. Burton Forum Award Talk: Remembering our Humanity: the deep impact of the Russell-Einstein Manifesto

    Science.gov (United States)

    Lewis, Patricia M.

    2009-05-01

    ``There lies before us, if we choose, continual progress in happiness, knowledge, and wisdom. Shall we, instead, choose death, because we cannot forget our quarrels? We appeal as human beings to human beings: Remember your humanity, and forget the rest.'' Days before his death, Albert Einstein joined Bertrand Russell and other notable scientists and philosophers in issuing a statement calling for the abolition of war and for governments to ``find peaceful means for the settlement of all matters of dispute between them." As a first step, they called for the renunciation of nuclear weapons. The initiative led to the establishment of the Pugwash Conferences on Science and World Affairs, which bring together influential scholars and public figures concerned with reducing the danger of armed conflict and seeking cooperative solutions for global problems. The Russell-Einstein Manifesto has had a major impact on the way in which people discuss the issues of peace and war. The paper traces the growing awareness of the meaning of war, ways in which violent conflict can be prevented, particularly in the nuclear age, and the humanitarian imperative for so doing. From the Russell-Einstein Manifesto, London, 9 July 1955, signed also by Max Born, Percy W. Bridgman, Leopold Infeld, Frederic Joliot-Curie, Herman J. Muller, Linus Pauling, Cecil F. Powell, Joseph Rotblat and Hideki Yukawa

  6. Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a jack russell terrier

    Directory of Open Access Journals (Sweden)

    JO'Neill Emma

    2010-07-01

    Full Text Available Abstract A twenty-month-old Jack Russell terrier was presented with a four-day history of thrombocytopenia, echymotic inguinal haemorrhages, coughing and reduced exercise tolerance. Clinical examination revealed several petechial haemorrhages on the gingivae and small echymotic haemorrhages in the inguinal region, along with mild bilateral epistaxis. Haematology confirmed a platelet count of 1.0 × 10/L. Thoracic radiographs revealed a wide-spread mixed alveolar-interstitial lung pattern, apparent throughout the entire lungfield, but particularly marked within the left lung lobes. A presumptive diagnosis of immune-mediated thrombocytopenia was made and the dog was treated with vincristine and immunosuppressive doses of prednisolone. Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement. Evaluation for an underlying cause of the disease revealed Angiostrongylus vasorum L1 larvae on faecal analysis and treatment with fenbendazole was commenced. The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis. This is the second report of immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection and it is the first to be successfully managed. The report highlights that Angiostrongylus vasorum should be considered in young dogs presented with thrombocytopenia.

  7. The mine and the furnace: Francis Bacon, Thomas Russell, and early Stuart mining culture.

    Science.gov (United States)

    Pastorino, Cesare

    2009-01-01

    Notwithstanding Francis Bacon's praise for the philosophical role of the mechanical arts, historians have often downplayed Bacon's connections with actual artisans and entrepreneurs. Addressing the specific context of mining culture, this study proposes a rather different picture. The analysis of a famous mining metaphor in The Advancement of Learning shows us how Bacon's project of reform of knowledge could find an apt correspondence in civic and entrepreneurial values of his time. Also, Bacon had interesting and so far unexplored links with the early modern English mining enterprises, like the Company of Mineral and Battery Works, ofwhich he was a shareholder. Moreover, Bacon's notes in a private notebook, Commentarius Solutus, and records of patents of invention, allow us to start grasping Bacon's connections with the metallurgist and entrepreneur Thomas Russell. Lastly, this paper argues that, to fully understand Bacon's links with the world of Stuart technicians and entrepreneurs, it is necessary to consider a different and insufficiently studied aspect of Bacon's interests, namely his work as patents referee while a Commissioner of Suits.

  8. Sindrome de russel tumor diencefálico em uma criança

    Directory of Open Access Journals (Sweden)

    Luiz A. C. Roxo da Motta

    1990-03-01

    Full Text Available Apresenta-se o caso de criança do sexo masculino com síndrome de Russel devida a astrocitoma pilocítico localizado na região diencefálica. O diagnóstico foi realizado aos 16 meses de idade, mas sua sintomatologia se iniciou aos 4 meses, com emagrecimento progressivo. À internação apresentava-se com peso de 6150g e 74cm de estatura, emaciada, sem panículo adiposo, irritadica e com sinais de hipertensão intracraniana. Existia estrabismo convergente, nistagmo vertical do olho esquerdo e papiledema bilateral. Os reflexos tendinosos eram exaltados e tinha tetraparesia espástica. A avaliação endócrina demonstrou aumento basal do GH (23 ng/ml, do TSH (6,2 mUI/l e da prolactina (26 ng/ml. Os dois primeiros hormônios não responderam ao teste agudo com o TRH, enquanto a prolactina teve resposta pobre. Foi submetida a radioterapia com acelerador linear (dose total de 4000 rads e a cirurgia, na qual não se conseguiu extirpar todo o tumor, devido a seu tamanho. Nove meses após, a criança encontra-se bem, com apreciável ganho ponderai (2500g.

  9. Silver-Russell Syndrome and Beckwith-Wiedemann Syndrome: Opposite Phenotypes with Heterogeneous Molecular Etiology

    Science.gov (United States)

    Õunap, Katrin

    2016-01-01

    Silver-Russell syndrome (SRS) and Beckwith-Wiedemann syndrome (BWS) are 2 clinically opposite growth-affecting disorders belonging to the group of congenital imprinting disorders. The expression of both syndromes usually depends on the parental origin of the chromosome in which the imprinted genes reside. SRS is characterized by severe intrauterine and postnatal growth retardation with various additional clinical features such as hemihypertrophy, relative macrocephaly, fifth finger clinodactyly, and triangular facies. BWS is an overgrowth syndrome with many additional clinical features such as macroglossia, organomegaly, and an increased risk of childhood tumors. Both SRS and BWS are clinically and genetically heterogeneous, and for clinical diagnosis, different diagnostic scoring systems have been developed. Six diagnostic scoring systems for SRS and 4 for BWS have been previously published. However, neither syndrome has common consensus diagnostic criteria yet. Most cases of SRS and BWS are associated with opposite epigenetic or genetic abnormalities in the 11p15 chromosomal region leading to opposite imbalances in the expression of imprinted genes. SRS is also caused by maternal uniparental disomy 7, which is usually identified in 5-10% of the cases, and is therefore the first imprinting disorder that affects 2 different chromosomes. In this review, we describe in detail the clinical diagnostic criteria and scoring systems as well as molecular causes in both SRS and BWS. PMID:27587987

  10. Myoclonus-dystonia and Silver-Russell syndrome resulting from maternal uniparental disomy of chromosome 7.

    Science.gov (United States)

    Sheridan, M B; Bytyci Telegrafi, A; Stinnett, V; Umeh, C C; Mari, Z; Dawson, T M; Bodurtha, J; Batista, D A S

    2013-10-01

    Myoclonus-dystonia (M-D) is a movement disorder that is often associated with mutations in epsilon-sarcoglycan (SGCE), a maternally imprinted gene at 7q21.3. We report a 24-year-old male with short stature (uniparental disomy. Parental SNP arrays confirmed that the proband had maternal uniparental disomy of chromosome 7 (mUPD7) with regions of heterodisomy and isodisomy. mUPD7 is the cause of approximately 5-10% of Silver-Russell syndrome (SRS), a disorder characterized by prenatal and postnatal growth retardation. Although SRS was not suspected in our patient, these findings explain his short stature. SGCE methylation testing showed loss of the unmethylated paternal allele. Our findings provide a unifying diagnosis for his short stature and M-D and help to optimize his medication regimen. In conclusion, we show that M-D is a clinical feature that may be associated with SRS due to mUPD7. Individuals with mUPD7 should be monitored for the development of movement disorders. Conversely, individuals with M-D and short stature should be evaluated for SRS.

  11. Synthesis and characterization of chitosan tripolyphosphate nanoparticles and its encapsulation efficiency containing Russell's viper snake venom.

    Science.gov (United States)

    Venkatesan, C; Vimal, S; Hameed, A S Sahul

    2013-08-01

    Chitosan Tripolyphosphate (CS/TPP) nanoparticle is a biodegradable and nontoxic polysaccharide, used as a carrier for drug delivery. The morphology and particle-size measurements of the nanoparticles were studied by field emission scanning electron microscopy and Fourier Transform Infrared Spectroscopy (FTIR). This study aims to evaluate the impact of Russell's viper venom encapsulation on various factors and loading capacity, in addition to explore the physicochemical structure of nanoparticles. FTIR confirmed that tripolyphosphoric groups of TPP linked with ammonium groups of CS in the nanoparticles. Our results showed that CS can react with TPP to form stable cationic nanoparticles. The results also showed that encapsulation efficiency of venom at different concentrations of 20, 40, 60, 500, and 1000 µg/mL were achieved for CS/TPP nanoparticles at different concentrations of 1.5, 2, and 3 mg/mL. The cytotoxicity of CS/TPP nanoparticles was evaluated by MTT (-3 (4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a tetrazole) assay.

  12. A CHRNE frameshift mutation causes congenital myasthenic syndrome in young Jack Russell Terriers.

    Science.gov (United States)

    Rinz, Caitlin J; Lennon, Vanda A; James, Fiona; Thoreson, James B; Tsai, Kate L; Starr-Moss, Alison N; Humphries, H Dale; Guo, Ling T; Palmer, Anthony C; Clark, Leigh Anne; Shelton, G Diane

    2015-12-01

    Congenital myasthenic syndromes (CMSs) are a group of rare genetic disorders of the neuromuscular junction resulting in structural or functional causes of fatigable weakness that usually begins early in life. Mutations in pre-synaptic, synaptic and post-synaptic proteins have been demonstrated in human cases, with more than half involving aberrations in nicotinic acetylcholine receptor (AChR) subunits. CMS was first recognized in dogs in 1974 as an autosomal recessive trait in Jack Russell Terriers (JRTs). A deficiency of junctional AChRs was demonstrated. Here we characterize a CMS in 2 contemporary cases of JRT littermates with classic clinical and electromyographic findings, and immunochemical confirmation of an approximately 90% reduction in AChR protein content. Loci encoding the 5 AChR subunits were evaluated using microsatellite markers, and CHRNB1 and CHRNE were identified as candidate genes. Sequences of the splice sites and exons of both genes revealed a single base insertion in exon 7 of CHRNE that predicts a frameshift mutation and a premature stop codon. We further demonstrated this pathogenic mutation in CHRNE in archival tissues from unrelated JRTs studied 34 years ago.

  13. The ornithologist Alfred Russel Wallace and the controversy surrounding the dinosaurian origin of birds.

    Science.gov (United States)

    Ibrahim, Nizar; Kutschera, Ulrich

    2013-12-01

    Over many years of his life, the British naturalist Alfred Russel Wallace (1823-1913) explored the tropical forests of Malaysia, collecting numerous specimens, including hundreds of birds, many of them new to science. Subsequently, Wallace published a series of papers on systematic ornithology, and discovered a new species on top of a volcano on Ternate, where he wrote, in 1858, his famous essay on natural selection. Based on this hands-on experience, and an analysis of an Archaeopteryx fossil, Wallace suggested that birds may have descended from dinosaurian ancestors. Here, we describe the "dinosaur-bird hypothesis" that originated with the work of Thomas H. Huxley (1825-1895). We present the strong evidence linking theropod dinosaurs to birds, and briefly outline the long and ongoing controversy around this concept. Dinosaurs preserving plumage, nesting sites and trace fossils provide overwhelming evidence for the dinosaurian origin of birds. Based on these recent findings of paleontological research, we conclude that extant birds indeed descended, with some modifications, from small, Mesozoic theropod dinosaurs. In the light of Wallace's view of bird origins, we critically evaluate recent opposing views to this idea, including Ernst Mayr's (1904-2005) arguments against the "dinosaur-bird hypothesis", and document that this famous ornithologist was not correct in his assessment of this important aspect of vertebrate evolution.

  14. Measuring dabigatran with the dilute Russell viper venom confirm assay in an anticoagulation clinic population.

    Science.gov (United States)

    McGlasson, David L; Fritsma, George A

    2016-01-01

    The dabigatran dose-response is predictable; however, it is necessary to measure plasma levels in a variety of clinical conditions. We evaluated a novel dabigatran measure - the 'dilute Russell viper venom confirm (DRVVC) assay' - against current developmental assays and a reference method. We measured plasma dabigatran and compared results from the Stago Sta-Clot DRVVC assay, Stago Ecarin Chromogenic Assay, Biophen Hemoclot Thrombin Inhibitor, and liquid chromatography tandem mass spectrometry. We obtained dabigatran calibrators and controls from Biophen, and performed the coagulation assays using a Stago STA-R Evolution coagulometer. Liquid chromatography tandem mass spectrometry method specimens were performed on an AB Sciex instrument at LabCorp. We enrolled 97 anticoagulation clinic patients (mean age 76 years) who were taking 150 mg dabigatran twice daily. All had creatinine clearances above 30 ml/min; patients were not excluded for concurrent medications or health issues. Citrated blood specimens were processed immediately, and stored at -70°C. We did not correlate collection time with medication time. We employed descriptive statistics, analysis of variance, and the Bland-Altman difference plot to assess the data. The range for all assays was 11.6-917 ng/ml. Analysis of variance generated a P value of 0.1 and Bland-Altman differences were all below 4.0% compared with DRVVC. The DRVVC measures dabigatran with validity comparable to other methods.

  15. Luminous blue variables at quiescence: The zone of avoidance in the Hertzsprung-Russell diagram

    Science.gov (United States)

    Stothers, Richard B.; Chin, Chao-Wen

    1994-01-01

    Two phases of dynamical instability are theoretically predicted to exist during the evolution of supergiants of normal metallicity that are initially more massive than approximately 60 solar mass. One phase occurs briefly in the yellow or red region of the Hertzsprung-Russell diagram for stars in the early stages of core helium burning, and the other phase occurs for a longer time in the blue or blue-white region for stars exhausting their core helium. Probably only the second phase exists in the case of supergiants with initial masses between approximately 60 solar mass and approximately 30 solar mass or with low metallicities The cause of instability is the partial ionization of hydrogen and helium in a quasi-isolated outer region of the stellar envelope, above the layer where the iron opacity attains a large local maximum. Predicted luminosities, effective temperatures, ejected nebular masses, remnant masses, eruption recurrence times, and lifetimes, though very approximate, are generally consistent with available observational data for the important class of unstable supergiants known as luminous blue variables.

  16. Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a Jack Russell terrier.

    Science.gov (United States)

    Jo'neill, Emma; Acke, Els; Tobin, Emma; McCarthy, Grainne

    2010-07-01

    A twenty-month-old Jack Russell terrier was presented with a four-day history of thrombocytopenia, echymotic inguinal haemorrhages, coughing and reduced exercise tolerance. Clinical examination revealed several petechial haemorrhages on the gingivae and small echymotic haemorrhages in the inguinal region, along with mild bilateral epistaxis. Haematology confirmed a platelet count of 1.0 × 10/L. Thoracic radiographs revealed a wide-spread mixed alveolar-interstitial lung pattern, apparent throughout the entire lungfield, but particularly marked within the left lung lobes. A presumptive diagnosis of immune-mediated thrombocytopenia was made and the dog was treated with vincristine and immunosuppressive doses of prednisolone. Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement. Evaluation for an underlying cause of the disease revealed Angiostrongylus vasorum L1 larvae on faecal analysis and treatment with fenbendazole was commenced. The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis. This is the second report of immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection and it is the first to be successfully managed. The report highlights that Angiostrongylus vasorum should be considered in young dogs presented with thrombocytopenia.

  17. Riparian and wetland ecological health : evaluation of selected streams on the Charles M. Russell National Wildlife Refuge : Appendix A : Key to riparian and wetland sites of Charles M. Russell National Wildlife Refuge and descriptions of habitat types and major seral community types of CMR NWR

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains a key to riparian and wetland sites, as well as description of habitat and community types for the Charles M. Russell National Wildlife Refuge...

  18. Molecular and clinical studies in 138 Japanese patients with Silver-Russell syndrome.

    Directory of Open Access Journals (Sweden)

    Tomoko Fuke

    Full Text Available BACKGROUND: Recent studies have revealed relative frequency and characteristic phenotype of two major causative factors for Silver-Russell syndrome (SRS, i.e. epimutation of the H19-differentially methylated region (DMR and uniparental maternal disomy 7 (upd(7mat, as well as multilocus methylation abnormalities and positive correlation between methylation index and body and placental sizes in H19-DMR epimutation. Furthermore, rare genomic alterations have been found in a few of patients with idiopathic SRS. Here, we performed molecular and clinical findings in 138 Japanese SRS patients, and examined these matters. METHODOLOGY/PRINCIPAL FINDINGS: We identified H19-DMR epimutation in cases 1-43 (group 1, upd(7mat in cases 44-52 (group 2, and neither H19-DMR epimutation nor upd(7mat in cases 53-138 (group 3. Multilocus analysis revealed hyper- or hypomethylated DMRs in 2.4% of examined DMRs in group 1; in particular, an extremely hypomethylated ARHI-DMR was identified in case 13. Oligonucleotide array comparative genomic hybridization identified a ∼3.86 Mb deletion at chromosome 17q24 in case 73. Epigenotype-phenotype analysis revealed that group 1 had more reduced birth length and weight, more preserved birth occipitofrontal circumference (OFC, more frequent body asymmetry and brachydactyly, and less frequent speech delay than group 2. The degree of placental hypoplasia was similar between the two groups. In group 1, the methylation index for the H19-DMR was positively correlated with birth length and weight, present height and weight, and placental weight, but with neither birth nor present OFC. CONCLUSIONS/SIGNIFICANCE: The results are grossly consistent with the previously reported data, although the frequency of epimutations is lower in the Japanese SRS patients than in the Western European SRS patients. Furthermore, the results provide useful information regarding placental hypoplasia in SRS, clinical phenotypes of the hypomethylated ARHI

  19. Regional economic impacts of current and proposed management alternatives for Charles M. Russell National Wildlife Refuge

    Science.gov (United States)

    Koontz, Lynne; Sexton, Natalie; Ishizaki, Asuka; Ritten, John

    2013-01-01

    The National Wildlife Refuge System Improvement Act of 1997 requires all units of the National Wildlife Refuge System to be managed under a Comprehensive Conservation Plan (CCP). The CCP must describe the desired future conditions of a refuge and provide long-range guidance and management direction to achieve refuge purposes. Charles M. Russell (CMR) National Wildlife Refuge, located in north-central Montana, is in the process of developing a range of management goals, objectives, and strategies for the CCP. The CCP for the Refuge must contain an analysis of expected effects associated with current and proposed refuge-management strategies. For refuge CCP planning, an economic analysis provides a means of estimating how current management (No Action Alternative) and proposed management activities (Alternatives) affect the local economy. This type of analysis provides two critical pieces of information: (1) it illustrates a refuge’s contribution to the local community; and (2) it can help in determining whether economic effects are or are not a real concern in choosing among management alternatives. It is important to note that the economic value of a refuge encompasses more than just the impacts on the regional economy. Refuges also provide substantial nonmarket values (values for items not exchanged in established markets) such as maintaining endangered species, preserving wetlands, educating future generations, and adding stability to the ecosystem (Carver and Caudill, 2007). However, quantifying these types of nonmarket values is beyond the scope of this study. This report first presents a description of the local community and economy near the Refuge. Next, the methods used to conduct a regional economic impact analysis are described. An analysis of the final CCP management strategies that could affect stakeholders and residents and the local economy is then presented. The refuge management activities of economic concern in this analysis are:

  20. Correction of the axial and appendicular deformities in a patient with Silver-Russel syndrome

    Directory of Open Access Journals (Sweden)

    Ali Al Kaissi

    2015-01-01

    Full Text Available Background: Scoliosis and limb length discrepancy are the major orthopaedic abnormalities in patients with Silver-Russel syndrome (SRS. In this paper, we describe a series of orthopaedic interventions in an attempt to overcome the progressive pathologic mechanism in a 7-year-old girl who manifested the full phenotypic features of SRS. Materials and Methods: Unilateral hip dislocation, progressive scoliosis and limb length discrepancy have been dealt with through Pemberton osteotomy, spinal fusion and Taylor-Spatial-Frame respectively. Results: In order to correct the axial and the appendicular deformities a sum of seven operations were performed (between the age of 7 years and 13 years. Pemberton osteotomy was performed to treat dislocation of her right hip because of developmental dysplasia of the hip. Spinal fusion (spondylodesis of segments Th3-L5 was done to correct her scoliosis. And, to overcome the limb length discrepancy of 15-cm we used Taylor-Spatial-Frame with percutaneous distal corticotomy of the femur, and the proximal tibia, as well as the foot, were performed. We were able to minimize the limb length discrepancy to 5 cm. The girl became able to walk with the aid of a below knee orthosis and through lifting the left limb with 5-cm height shoe. Conclusion: Limb lengthening surgery in patients with multiple malformation complex as in SRS is associated with high recurrence risk because of; muscular hypotonia, overtubulation of the long bones, and the poor bone regenerative quality. Our interventions were principally directed towards improving the cosmetic outlook, functions and the biomechanics.

  1. Role of the Russell-McPherron Effect in the Acceleration of Relativistic Electrons

    Science.gov (United States)

    McPherron, R. L.; Baker, D. N.; Crooker, N. U.

    2010-01-01

    While it is well known that high fluxes of relativistic electrons in the Earth's radiation belts are associated with high-speed solar wind and its heightened geoeffectiveness,less known is the fact that the Russell McPherron(R M) effect strongly controls whether or not a given high-speed stream is geoffective. To test whether it then follows that the R M effect also strongly controls fluxes of relativistic electrons, we perform a superposed epoch analysis across corotating interaction regions (CIR) keyed on the interfaces between slow and fast wind. A total of 394 stream interfaces were identified in the years 1994-2006. Equinoctial interfaces were separated into four classes based on the R-M effect,that is, whether the solar wind on either side of the interface was either(geo)effective (E) or ineffective (I) depending on season and the polarity of the interplanetary magnetic field (IMF). Four classes of interface identified as II, IE, EI,and EE are possible. The classes IE and EI correspond to CIRs with polarity changes indicating passage through the heliospheric current sheet. To characterize the behavior of solar wind and magnetospheric variables, we produced maps of dynamic cumulative probability distribution functions (cdfs) as a function of time over 10-day intervals centered on the interfaces. These reveal that effective high-speed streams have geomagnetic activity nearly twice as strong as ineffective streams and electron fluxes a factor of 12 higher. In addition they show that an effective low-speed stream increases the flux of relativistic electrons before the interface so that an effective to ineffective transition results in lower fluxes after the interface.We conclude that the R-M effect plays a major role in organizing and sustaining a sequence of physical processes responsible for the acceleration of relativistic electrons.

  2. Impact of fine debris on ice melt rates at Russell Glacier, central-west Greenland

    Science.gov (United States)

    Carr, Rachel; Linighan, James; Cumming, Alex M. J.

    2017-04-01

    Losses from the Greenland Ice Sheet (GrIS) have increased sharply in recent years, due to accelerated glacier discharge and increased surface melting. In 2012, 99% of the Greenland ice sheet experienced melt, which was exceptional on centennial timescales, but is expected to occur frequently in the future, as climate warms. Ice albedo is a primary control on melt rates and remotely sensed data shows that the GrIS has darkened substantial in recent decades, due to both inorganic and biological material. This has been particularly marked in south- and central-west Greenland and can lead to the development of positive feedbacks. Consequently, it is important to understand the relationship between melt and surface albedo on the GrIS. Here we use a combination of satellite remote sensing and field data to assess the impact of fine debris on melt rates at Russell Glacier, central-west Greenland. Our field data demonstrate that areas with a greater percentage coverage of fine, largely inorganic debris experienced higher melt rates than in areas with a sparse coverage. However, the relationship between melt and debris cover was highly spatially variable. Furthermore, the debris cover evolved substantially over time and we saw marked changes over a period of a few days. Using ASTER imagery, we show that the spatial extent of debris has expanded markedly in this section of the GrIS during the last decade, which could substantially accelerate melting. However, the complex and variable relationship between debris cover and melt rates highlights the need for further research, in order to accurately forecast its impact on GrIS melt rates.

  3. Bites by Russell's vipers (Daboia russelii siamensis) in Myanmar: effect of the snake's length and recent feeding on venom antigenaemia and severity of envenoming.

    Science.gov (United States)

    Tun-Pe; Ba-Aye; Aye-Aye-Myint; Tin-Nu-Swe; Warrell, D A

    1991-01-01

    An improved enzyme immunoassay technique (EIA) was used in the diagnosis of 311 suspected Russell's viper bite cases in Myanmar [Burma], 181 of whom (58%) had systemic envenoming. Russell's viper venom was detected in the sera of 175 (56.3%), cobra or green pit viper venoms in 4 (1.3%), and no venom in the remaining 132 (42.4). Among 175 of these patients who failed to bring the dead snake, EIA achieved a specific diagnosis of Russell's viper envenoming in 101 (58%). The serum venom antigen concentration was higher in patients with systemic envenoming than in those with local or no envenoming and it increased with the development of coagulopathy. Stomach contents were examined in 101 Russell's vipers responsible for bites. The presence of prey, usually a rodent, in the snake's stomach, indicating that it had eaten recently, did not influence the severity of envenoming, the initial venom level, or the percentage circumference increase and the extent of local swelling in the bitten limb. One hundred and fifty-five Russell's vipers responsible for bites showed a bimodal distribution of total lengths. The smaller snakes had probably been born that year. Longer snakes were responsible for more severe envenoming, a shorter interval between the bite and the detection of incoagulable blood, and more extensive local swelling with a greater percentage circumference increase of the bitten limb; but their bites were not associated with higher initial venom antigenaemia or a greater risk of developing acute renal failure.

  4. Hubbard Glacier, Alaska: growing and advancing in spite of global climate change and the 1986 and 2002 Russell Lake outburst floods

    Science.gov (United States)

    Trabant, Dennis C.; March, Rod S.; Thomas, Donald S.

    2003-01-01

    Hubbard Glacier, the largest calving glacier on the North American Continent (25 percent larger than Rhode Island), advanced across the entrance to 35-mile-long Russell Fiord during June 2002, temporarily turning it into a lake. Hubbard Glacier has been advancing for more than 100 years and has twice closed the entrance to Russell Fiord during the last 16 years by squeezing and pushing submarine glacial sediments across the mouth of the fiord. Water flowing into the cutoff fiord from mountain streams and glacier melt causes the level of Russell Lake to rise. However, both the 1986 and 2002 dams failed before the lake altitude rose enough for water to spill over a low pass at the far end of the fiord and enter the Situk River drainage, a world-class sport and commercial fishery near Yakutat, Alaska.

  5. Comments on 'The magnetic field of Mars - Implications from gas dynamic modeling' by C. T. Russell, J. C. Luhmann, J. R. Spreiter, and S. S. Stahara

    Science.gov (United States)

    Dolginov, Sh. SH.

    1986-01-01

    The Russell et al. (1984) claim that gas dynamic modeling allows a determination of interplanetary and magnetosheath field configurations resembling the Mars 3 magnetic field observations during the January 21, 1972 encounter, and their proposal of a draped magnetic field pattern model for these data, are presently disputed. Extensive use is made of Martian magnetic field analyses undertaken by Dolginov between 1973 and 1984, which are held to prove the existence of an intrinsic Martian magnetic field. Russell replies that the Russell et al. analysis of the variation in the Mars 2, 3, and 5 data suggests the presence of both zero-level and sensor polarity errors in these data. The rejection of an intrinsic Martian magnetic field is accordingly reaffirmed, pending the availability of less ambiguous data.

  6. Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii envenomings.

    Directory of Open Access Journals (Sweden)

    Kalana Maduwage

    2014-12-01

    Full Text Available Venom recurrence or persistence in the circulation after antivenom treatment has been documented many times in viper envenoming. However, it has not been associated with clinical recurrence for many snakes, including Russell's viper (Daboia spp.. We compare the recovery of coagulopathy to the recurrence or persistence of venom in patients with Russell's viper envenoming.The study included patients with Russell's viper (D. russelii envenoming presenting over a 30 month period who had Russell's viper venom detected by enzyme immunoassay. Demographics, information on the snake bite, and clinical effects were collected for all patients. All patients had serum collected for venom specific enzyme immunoassay and citrate plasma to measure fibrinogen levels and prothrombin time (international normalised ratio; INR. Patients with venom recurrence/persistence were compared to those with no detectable recurrence of venom. There were 55 patients with confirmed Russell's viper envenoming and coagulopathy with low fibrinogen concentrations: 31 with venom recurrence/persistence, and 24 with no venom detected post-antivenom. Fibrinogen concentrations increased and INR decreased after antivenom in both the recurrence and non-recurrence patients. Clinical features, laboratory parameters, antivenom dose and length of hospital were similar for both groups. Pre-antivenom venom concentrations were higher in patients with venom recurrence/persistence with a median venom concentration of 385 ng/mL (16-1521 ng/mL compared to 128 ng/mL (14-1492 ng/mL; p = 0.008.Recurrence of Russell's viper venom was not associated with a recurrence of coagulopathy and length of hospital stay. Further work is required to determine if the detection of venom recurrence is due to the venom specific enzyme immunoassay detecting both venom-antivenom complexes as well as free venom.

  7. Heritability and complex segregation analysis of deafness in Jack Russell Terriers

    Directory of Open Access Journals (Sweden)

    Strain George M

    2007-11-01

    Full Text Available Abstract Background The association between patterns of pigmentation and deafness in the dog has a long-documented history, with reports dating back over one hundred years. Long suspected of having a genetic basis, the search for loci with a pronounced influence in the expression of hearing loss in the dog has yet to be successful. No studies in the dog to date have found a possible influence of a specific colour locus associated with deafness. The present study is intended to evaluate the heritability of deafness in the Jack Russell Terrier (JRT, characterize the mode of inheritance, and evaluate the existence of a sex, coat colour, or coat texture influence on the expression of sensorineural deafness. Results The estimation of heritability of deafness in the JRT was 0.22 when deafness was considered a binary (normal/deaf trait and 0.31 when deafness was considered a three-category (normal/unilateral/bilateral deafness. The influence of coat colour in the incidence of JRT deafness was statistically significant, indicating that dogs with more white are more likely to be deaf. The influence of sex or coat texture was not statistically significant in the incidence of JRT deafness. Complex segregation analysis revealed a model of a single locus with a large effect on the binary measure of hearing loss is not supported. Conclusion This is the first attempt, to our knowledge, to characterize a genetic component responsible for deafness in the JRT. The heritability of deafness in the JRT was found to be 0.22 and 0.31 considering deafness to be a two-category or three-category trait, respectively. There appears to be an influence of coat colour on the expression of deafness. In an attempt to characterize the mode of inheritance of deafness in the JRT, a model of a single locus with a large effect on hearing loss is not supported with this data. Further study is needed to determine if a single locus may be influencing deafness in the JRT. While the

  8. Deletions and rearrangements of the H19/IGF2 enhancer region in patients with Silver-Russell syndrome and growth retardation

    DEFF Research Database (Denmark)

    Grønskov, Karen; Poole, Rebecca L; Hahnemann, Johanne M D

    2011-01-01

    Silver-Russell syndrome (SRS) is characterised by prenatal and postnatal growth retardation, dysmorphic facial features, and body asymmetry. In 35-60% of SRS cases the paternally methylated imprinting control region (ICR) upstream of the H19 gene (H19-ICR) is hypomethylated, leading to downregula......Silver-Russell syndrome (SRS) is characterised by prenatal and postnatal growth retardation, dysmorphic facial features, and body asymmetry. In 35-60% of SRS cases the paternally methylated imprinting control region (ICR) upstream of the H19 gene (H19-ICR) is hypomethylated, leading...

  9. The relationship between the Russell-McPherron effect and solar wind entry under northward IMF condition

    Science.gov (United States)

    Bai, Shichen; Shi, Quanqi; Tian, Anmin; Nowada, Motoharu; Zong, Qiugang; Fu, Suiyan; Zhou, Xuzhi; Pu, Zuyin

    2017-04-01

    The strong magnetic storms tend to occur in March and September. This phenomenon can be explained by the Russell-McPherron (R-M) effect, since the Bz magnitude is enhanced in March and September under southward IMF condition. Same mechanism should be valid under northward IMF condition, and the semiannual variation of geomagnetic activity under northward IMF condition could be expected. In this paper, the R-M effect under northward IMF condition is verified by utilizing 42 years of Interplanetary Magnetic Field (IMF) data. Cold-dense plasma sheet occurrence is chosen to investigate the monthly variation of solar wind entry under northward IMF condition. CDPS events are identified using multiple satellites' data between 1996 and 2014. We found that the seasonal variation of northward IMF and the occurrence rate of CDPS have semiannual period, these phenomena are related to the R-M effect.The R-M effect will affect the solar wind entry under northward IMF condition. Keywords: Semiannual variation, Russell-McPherron effect, Cold-dense plasma sheet

  10. Estimation of Streamflow Characteristics for Charles M. Russell National Wildlife Refuge, Northeastern Montana

    Science.gov (United States)

    Sando, Steven K.; Morgan, Timothy J.; Dutton, DeAnn M.; McCarthy, Peter M.

    2009-01-01

    Charles M. Russell National Wildlife Refuge (CMR) encompasses about 1.1 million acres (including Fort Peck Reservoir on the Missouri River) in northeastern Montana. To ensure that sufficient streamflow remains in the tributary streams to maintain the riparian corridors, the U.S. Fish and Wildlife Service is negotiating water-rights issues with the Reserved Water Rights Compact Commission of Montana. The U.S. Geological Survey, in cooperation with the U.S. Fish and Wildlife Service, conducted a study to gage, for a short period, selected streams that cross CMR, and analyze data to estimate long-term streamflow characteristics for CMR. The long-term streamflow characteristics of primary interest include the monthly and annual 90-, 80-, 50-, and 20-percent exceedance streamflows and mean streamflows (Q.90, Q.80, Q.50, Q.20, and QM, respectively), and the 1.5-, 2-, and 2.33- year peak flows (PK1.5, PK2, and PK2.33, respectively). The Regional Adjustment Relationship (RAR) was investigated for estimating the monthly and annual Q.90, Q.80, Q.50, Q.20, and QM, and the PK1.5, PK2, and PK2.33 for the short-term CMR gaging stations (hereinafter referred to as CMR stations). The RAR was determined to provide acceptable results for estimating the long-term Q.90, Q.80, Q.50, Q.20, and QM on a monthly basis for the months of March through June, and also on an annual basis. For the months of September through January, the RAR regression equations did not provide acceptable results for any long-term streamflow characteristic. For the month of February, the RAR regression equations provided acceptable results for the long-term Q.50 and QM, but poor results for the long-term Q.90, Q.80, and Q.20. For the months of July and August, the RAR provided acceptable results for the long-term Q.50, Q.20, and QM, but poor results for the long-term Q.90 and Q.80. Estimation coefficients were developed for estimating the long-term streamflow characteristics for which the RAR did not provide

  11. [The concomitance of pericarditis constrictiva in patient with Silver-Russell syndrome, primary hyperparathyroidism and oncologic history: causal coincidence or pathogenetic sequence?].

    Science.gov (United States)

    Banach, Monika; Zapolski, Tomasz; Drozd, Jakub; Wysokiński, Andrzej

    2011-01-01

    The most common cause of calcific pericarditis is idiopathic. We report a case of a 24 year-old woman with Silver-Russell syndrome, history of Wilms' tumour in childhood, constrictive pericarditis and primary hyperparathyroidism. We analyse pathologic mechanisms of disseminated calcification and possible genetic factors that may contribute to aetiology and clinical presentation of calcific pericarditis.

  12. 成人 Silver-Russell 综合征1例并文献复习%A rare case of Silver-Russell syndrome in adult and literature review

    Institute of Scientific and Technical Information of China (English)

    卢佩颖; 谷卫; 庞晓虹; 单鹏飞

    2015-01-01

    Silver-Russell syndrome ( SRS ) is a rare genetic disorder with non-specific manifestations and severity , so that the clinical diagnosis of SRS remains difficult.We reported a 23-year-old female patient with SRS characterized with short body stature , asymmetry, obesity, fifth finger clinodactyly and dislocation of hip .The patient had a past history of lengthening operation on the right lower limb at the age of 10.Chromosome analysis revealed (46, XX).The patient was admitted due to severe asymmetry in low extremities caused by right-side obesity .After successful orthopedic surgery in the right hips and thighs the symptoms of patient were relieved .%Silver-Russell综合征是罕见遗传性疾病,临床表现异质性大,故诊断困难。1例成人女性Silver-Russell 综合征患者,以身材矮小、肢体不对称伴右侧肥胖、第五手指弯斜和髋关节脱位为主要临床表现,染色体检测提示(46,XX)。患者10岁时曾行右下肢延长手术。入院时肢体不对称伴右侧肥胖影响肢体功能,入院后行右侧臀部和大腿整形术,术后运动功能好转。

  13. Genomic imbalance in the centromeric 11p15 imprinting center in three families: Further evidence of a role for IC2 as a cause of Russell-Silver syndrome.

    Science.gov (United States)

    Cytrynbaum, Cheryl; Chong, Karen; Hannig, Vickie; Choufani, Sanaa; Shuman, Cheryl; Steele, Leslie; Morgan, Thomas; Scherer, Stephen W; Stavropoulos, Dimitri J; Basran, Raveen K; Weksberg, Rosanna

    2016-10-01

    Russell-Silver syndrome is a heterogeneous disorder characterized by intrauterine growth retardation, postnatal growth deficiency, characteristic facial appearance, and other variable features. Genetic and epigenetic alterations are identified in about 60% of individuals with Russell-Silver syndrome. Most frequently, Russell-Silver syndrome is caused by altered gene expression on chromosome 11p15 due to loss of methylation at the telomeric imprinting center. To date there have been a handful of isolated clinical reports implicating the centromeric imprinting center 2 in the etiology of Russell-Silver syndrome. Here we report three new families with genomic imbalances, involving imprinting center 2 resulting in gain of methylation at this center and a Russell-Silver syndrome phenotype, including two families with a maternally inherited microduplication and the first pediatric patient with a paternally derived microdeletion. The findings in our families provide additional evidence of a role for imprinting center 2 in the etiology of Russell-Silver syndrome and suggest that imprinting center 2 imprinting abnormalities may be a more common cause of Russell-Silver syndrome than previously recognized. Furthermore, our findings together with previous clinical reports of genomic imbalances involving imprinting center 2 serve to underscore the complexity of the epigenetic regulation of the 11p15 region making it challenging to predict phenotype on the basis of genotype alone. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. Complex tissue-specific epigenotypes in Russell-Silver Syndrome associated with 11p15 ICR1 hypomethylation.

    Science.gov (United States)

    Azzi, Salah; Blaise, Annick; Steunou, Virginie; Harbison, Madeleine D; Salem, Jennifer; Brioude, Frédéric; Rossignol, Sylvie; Habib, Walid Abi; Thibaud, Nathalie; Neves, Cristina Das; Jule, Marilyne Le; Brachet, Cécile; Heinrichs, Claudine; Bouc, Yves Le; Netchine, Irène

    2014-10-01

    Russell-Silver Syndrome (RSS) is a prenatal and postnatal growth retardation syndrome caused mainly by 11p15 ICR1 hypomethylation. Clinical presentation is heterogeneous in RSS patients with 11p15 ICR1 hypomethylation. We previously identified a subset of RSS patients with 11p15 ICR1 and multilocus hypomethylation. Here, we examine the relationships between IGF2 expression, 11p15 ICR1 methylation, and multilocus imprinting defects in various cell types from 39 RSS patients with 11p15 ICR1 hypomethylation in leukocyte DNA. 11p15 ICR1 hypomethylation was more pronounced in leukocytes than in buccal mucosa cells. Skin fibroblast IGF2 expression was correlated with the degree of ICR1 hypomethylation. Different tissue-specific multilocus methylation defects coexisted in 38% of cases, with some loci hypomethylated and others hypermethylated within the same cell type in some cases. Our new results suggest that tissue-specific epigenotypes may lead to clinical heterogeneity in RSS.

  15. Helicobacter pylori-negative Russell body gastritis: does the diagnosis call for screening for plasmacytic malignancies, especially multiple myeloma?

    Science.gov (United States)

    Klair, Jagpal Singh; Girotra, Mohit; Kaur, Aneet; Aduli, Farshad

    2014-03-26

    Russell body gastritis (RBG) is a rare entity with unestablished pathophysiology, endoscopic findings, clinical manifestations and treatments. Literature is scarce on this clinical entity with unclear clinical significance. Of 18 cases reported, 12 tested (+) for Helicobacter pylori and improved with treatment, but it remains unclear whether this link is coincidental or bears some clinical significance. We describe a case of elderly woman who had a follow-up oesophagogastroduodenoscopy for chronic peptic ulcers, and biopsy showed positive immunohistochemical stains for κ and λ, indicating a polytypic population of plasma cells. Immunostaining for H pylori was negative. Biopsies were also (-) for gastric carcinoma, lymphoma and plasmacytoma. Considering her RGB-suggestive histology and her symptoms of bone pains and anaemia, multiple myeloma screening was considered clinically relevant. The purpose of this review was to educate clinicians and gastroenterologists about this unique entity and explore its association with multiple myeloma or other plamacytic malignancies.

  16. Evolucionismo darwinista? Contribuições de Alfred Russel Wallace à teoria da evolução

    Directory of Open Access Journals (Sweden)

    Nelson Papavero

    2014-06-01

    Full Text Available Teria sido mesmo Charles Darwin o autor da teoria do processo evolutivo? Em suas pesquisas, Darwin discute mais a origem da seleção natural do que propriamente a origem das espécies. Três anos antes da publicação do artigo de Darwin, outro naturalista, Alfred Russel Wallace, publicou um trabalho propondo que todas as espécies vivas descendiam de um único ancestral comum. Foi Wallace o primeiro a notar que cada margem dos rios amazônicos podia ser habitada por espécies diferentes de macacos. Em 1858, Wallace sintetiza a teoria da seleção natural, mas ao invés de publicar a descoberta, remete-a para Darwin que, pouco tempo depois, publica A Origem das Espécies. Este artigo visa discutir quais seriam as contribuições de Wallace para as teorias evolutivas.

  17. Population Pharmacokinetics of an Indian F(ab'2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii Bites.

    Directory of Open Access Journals (Sweden)

    Geoffrey K Isbister

    Full Text Available There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell's viper bites.Patient data and serial blood samples were collected from patients with Russell's viper (Daboia russelii envenoming in Sri Lanka. All patients received Indian F(ab'2 snake antivenom manufactured by VINS Bioproducts Ltd. Antivenom concentrations were measured with sandwich enzyme immunoassays. Timed antivenom concentrations were analysed using MONOLIXvs4.2. One, two and three compartment models with zero order input and first order elimination kinetics were assessed. Models were parameterized with clearance (CL, intercompartmental clearance (Q, central compartment volume (V and peripheral compartment volume (VP. Between-subject-variability (BSV on relative bioavailability (F was included to account for dose variations. Covariates effects (age, sex, weight, antivenom batch, pre-antivenom concentrations were explored by visual inspection and in model building. There were 75 patients, median age 57 years (40-70 y and 64 (85% were male. 411 antivenom concentration data points were analysed. A two compartment model with zero order input, linear elimination kinetics and a combined error model best described the data. Inclusion of BSV on F and weight as a covariate on V improved the model. Inclusion of pre-antivenom concentrations or different batches on BSV of F did not. Final model parameter estimates were CL,0.078 L h(-1, V,2.2L, Q,0.178 L h(-1 and VP,8.33L. The median half-life of distribution was 4.6 h (10-90%iles:2.6-7.1 h and half-life of elimination, 140 h (10th-90th percentilesx:95-223h.Indian F(ab'2 snake antivenom displayed biexponential disposition pharmacokinetics, with a rapid distribution half-life and more prolonged elimination half-life.

  18. Proximal femoral nail antirotation combined with cable internal fixation for the treatment of Russell-Taylor type Ⅱ femoral subtrochanteric fracture%股骨近端防旋髓内钉结合钢缆治疗 Russell-TaylorⅡ型股骨转子下骨折

    Institute of Scientific and Technical Information of China (English)

    董飞; 李爱国; 王文; 叶伟雄; 陈鸿辉

    2015-01-01

    Objective To investigate curative effect of proximal femoral nail antirotation ( PFNA) combined with ca-ble in treatment of Russell-Taylor typeⅡfemoral subtrochanteric fracture. Methods 21 cases of Russell-Taylor typeⅡ femoral subtrochanteric fractures were treated with PFNA combined with cable. Results The operation time was 62~127 min, the blood loss was 150~420 ml. Good fracture reduction and reliable fixation were obtained. 21 cases were followed up for 7~20 months, and fracture healing time was 5~9 months, with Harris score of 79~93, there were 15 excellent cases, 5 good, and 1 fair. Conclusions PFNA combined with cable for the treatment of Russell-Taylor type Ⅱ femoral subtrochanteric fracture is an effective methrod.%目的 探讨股骨近端防旋髓内钉( PFNA) 结合钢缆治疗Russell-TaylorⅡ型股骨转子下骨折的疗效. 方法 采用PFNA联合钢缆捆扎固定治疗21 例Russell-Taylor Ⅱ型股骨转子下骨折患者. 结果 手术时间62~127 min,术中出血量150~420 ml,患者均骨折复位良好,内固定可靠. 21 例均获得随访,时间7~20 个月. 骨折愈合时间5~9个月. 患髋关节Harris 评分为79~93分,其中优15 例,良5 例,中1 例. 结论 PF-NA 结合钢缆是治疗Russell-Taylor Ⅱ型股骨转子下骨折有效的手段.

  19. Genome-wide association study for hereditary ataxia in the Parson Russell Terrier and DNA-testing for ataxia-associated mutations in the Parson and Jack Russell Terrier.

    Science.gov (United States)

    Gast, Alana Christina; Metzger, Julia; Tipold, Andrea; Distl, Ottmar

    2016-10-10

    Spinocerebellar ataxia also referred to as hereditary ataxia comprises different forms of progressive neurodegenerative diseases. A complex mode of inheritance was most likely in Parson Russell Terriers (PRT) and in Jack Russell Terriers (JRT). Recently, the missense mutation KCNJ10:c.627C > G was shown to be associated with the spinocerebellar ataxia (SCA) in JRT and related Russell group of terriers, whereas the missense mutation CAPN1:c.344G > A was associated with late onset ataxia (LOA) in PRT. We performed a genome-wide association study (GWAS) in PRT including 15 cases and 29 controls and found a statistically strong signal in the genomic region on dog chromosome 38 (CFA38) where KCNJ10 is located. We tested the CAPN1:c.344G > A and KCNJ10:c.627C > G (Transcript XM_545752.4) mutations in a sample of 77 PRT and 9 JRT from Germany as well as further 179 controls from 20 different dog breeds. All cases and controls genotyped carried the wild-type for the CAPN1:c.344G > A mutation. Among the PRT, 17/77 (22.1 %) dogs were homozygous for the mutant KCNJ10 allele and 22/77 (28.6 %) dogs were heterozygous. Three cases of PRT had the homozygous KCNJ10 wild-type. In JRT, 1/3 cases did show the mutant KCNJ10 allele homozygous. Thus, we sequenced the KCNJ10 exons with their adjacent regions from 10 PRT and 3 JRT including the animals with imperfect co-segregation of the c.627C > G mutation. We identified a total of 45 genetic variants within KCNJ10. The most likely variant explaining the cases appeared a 1-bp-insertion in a C-stretch within exon 3 (KCNJ10:g.22141027insC). In silico analysis showed that this indel may influence the regulation of gene expression. In the present study, 16/21 cases of hereditary ataxia perfectly co-segregated with the KCNJ10:c.627C > G mutation. The CAPN1:c.344G > A mutation could not be validated and seems to be a rare variant in the samples screened. Screening KCNJ10 for further mutations did result in a

  20. Charles M. Russell National Wildlife Refuge : Proposal for Developing a Sentinel Plant Inventory and Monitoring Protocol that is Complementary with Ecological Site Descriptions and The National Vegetation Classification System

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Proposal to develop an inventory and monitoring protocol for sentinel plants species on the Charles M. Russell National Wildlife Refuge. Sentinel species produce the...

  1. 1980 annual narrative report for Charles M. Russell National Wildlife Refuge, Hailstone National Wildlife Refuge, Halfbreed National Wildlife Refuge, Lake Mason National Wildlife Refuge, War Horse National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Charles M. Russell National Wildlife Refuge (including the satellite refuges) outlines Refuge accomplishments during the 1980 calendar...

  2. The monitoring of ice sheet movement using multiple spaceborne data fusion: A case study of a remote sensing observation over Russell Glacier in Greenland

    Science.gov (United States)

    Choi, Y.; Kim, J.; Lin, S. Y.; Chen, W. C.

    2014-12-01

    The changes of ice sheet in Greenland have been traced through various remote sensing observations. However, it was realised that the uncertainties in the observed change of ice sheet were not fully addressed. Therefore, we devised and tested a scheme employing multiple sensor satellite data and the data fusion to spatially and temporally monitor the migration of glacier with high accuracy. The test area was established in Russell glacier in western Greenland where the change of glacier has been obvious for the last century. Firstly, differential interferometric SAR (D-InSAR) campaigns using ALOS PALSAR pairs were applied to monitor the glacial change. In terms of data fusion aspect, we then employed pixel tracing method by co-registration of ALOS PRISM optical images over target area to compensate for any line-of-sight glacial movement resulted by the D-InSAR analysis. To securely trace individual pixel, high accuracy sub-pixel co-registration algorithm was developed. Meanwhile, PALSAR pairs were also applied to test the amplitude tracking method in the same manner. To address the temporal difference between the acquisition of SAR and optical images, the velocity vectors considering seasonal mean migration were interpolated. At last, the outputs from analyses were incorporated to build an effective 3D movement tracing over Russell glacier. Furthermore, in order to investigate the glacial migration process, the hydrodynamic simulations employing optical stereo pairs and InSAR DTMs over meltwater outflow channels, such as Akuliarusiarsuup Kuua and Qinnguata Kuussua from Russell glacier, were conducted simultaneously with the tracking of the geometric movement of glacier. The overall results were anticipated to be incorporated for the understanding of long term change of Russell glacier. Based on the output of this case study, the proposed method will be extended into a comprehensive scheme to tackle the issues of ice sheet change occurred in the Greenland.

  3. Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine.

    Science.gov (United States)

    Shenoy, P A; Nipate, S S; Sonpetkar, J M; Salvi, N C; Waghmare, A B; Chaudhari, P D

    2014-01-15

    Piper longum L. fruits have been traditionally used against snakebites in north-eastern and southern region of India. The aim of the study was to assess the production of antibody response against Russell's viper venom in mice after prophylactic immunization with ethanolic extract of fruits of Piper longum L. and piperine. The mice sera were tested for the presence of antibodies against Russell's viper venom by in vitro lethality neutralization assay and in vivo lethality neutralization assay. Polyvalent anti-snake venom serum (antivenom) manufactured by Haffkine Bio-Pharmaceutical Corporation Ltd. was used as standard. Further confirmation of presence of antibodies against the venom in sera of mice immunized with PLE and piperine was done using indirect enzyme-linked immunosorbent assay (ELISA) and double immunodiffusion test. Treatment with PLE-treated mice serum and piperine-treated mice serum was found to inhibit the lethal action of venom both in the in vitro lethality neutralization assay and in vivo lethality neutralization assay. ELISA testing indicated that there were significantly high (ppiperine treated mice serum and the venom antigens. In double immunodiffusion test, a white band was observed between the two wells of antigen and antibodies for both the PLE-treated and piperine-treated mice serum. Thus it can be concluded that immunization with ethanolic extract of fruits of Piper longum and piperine produced a high titre antibody response against Russell's viper venom in mice. The antibodies against PLE and piperine could be useful in antivenom therapy of Russell's viper bites. PLE and piperine may also have a potential interest in view of the development of antivenom formulations used as antidote against snake bites.

  4. Processamento auditivo, leitura e escrita na síndrome de Silver-Russell: relato de caso Auditory processing, reading and writing in the Silver-Russell syndrome: case report

    Directory of Open Access Journals (Sweden)

    Patrícia Fernandes Garcia

    2012-03-01

    Full Text Available O objetivo deste trabalho foi descrever os aspectos fonoaudiológicos de processamento auditivo, leitura e escrita de um paciente do gênero masculino com diagnóstico de síndrome de Silver-Russell. Aos dois meses de idade o paciente apresentava déficit pôndero-estatural; frontal amplo; orelhas pequenas, proeminentes e com baixa implantação; palato ogival; discreta micrognatia; esclera azulada; manchas café-com-leite; sobreposição do primeiro e segundo artelhos à direita; refluxo gastroesofágico; voz e choro agudos; atraso leve no desenvolvimento neuropsicomotor; e dificuldade de ganhar peso, recebendo o diagnóstico da síndrome. Na avaliação psicológica, realizada aos 8 anos de idade, o paciente apresentou nível intelectual normal, com dificuldades cognitivas envolvendo atenção sustentada, concentração, memória verbal imediata e processos emocionais e comportamentais. Para avaliação da leitura e escrita e de seus processos subjacentes, realizada aos 9 anos de idade foram utilizados os testes de Compreensão Leitora de Textos Expositivos, Perfil das Habilidades Fonológicas, Teste de Discriminação Auditiva, escrita espontânea, Teste de Desempenho Escolar (TDE, teste de Nomeação Automática Rápida e prova de memória de trabalho fonológica. Apresentou dificuldades em todos os testes, estando as pontuações abaixo do esperado para sua idade. Na avaliação do processamento auditivo foram realizados testes monóticos, dióticos e dicóticos. Foram encontradas alterações nas habilidades de atenção auditiva sustentada e seletiva, memória sequencial para sons verbais e não-verbais, e resolução temporal. Conclui-se que o paciente apresenta alterações na aprendizagem da leitura e escrita que podem ser secundários a síndrome de Silver-Russell, porém tais dificuldades também podem ser decorrentes das alterações em habilidades do processamento auditivo.The aim of this study was to describe the speech

  5. Structural and functional characterization of complex formation between two Kunitz-type serine protease inhibitors from Russell's Viper venom.

    Science.gov (United States)

    Mukherjee, Ashis K; Dutta, Sumita; Kalita, Bhargab; Jha, Deepak K; Deb, Pritam; Mackessy, Stephen P

    2016-01-01

    Snake venom Kunitz-type serine protease inhibitors (KSPIs) exhibit various biological functions including anticoagulant activity. This study elucidates the occurrence and subunit stoichiometry of a putative complex formed between two KSPIs (Rusvikunin and Rusvikunin-II) purified from the native Rusvikunin complex of Pakistan Russell's Viper (Daboia russelii russelii) venom (RVV). The protein components of the Rusvikunin complex were identified by LC-MS/MS analysis. The non-covalent interaction between two major components of the complex (Rusvikunin and Rusvikunin-II) at 1:2 stoichiometric ratio to form a stable complex was demonstrated by biophysical techniques such as spectrofluorometric, classical gel-filtration, equilibrium gel-filtration, circular dichroism (CD), dynamic light scattering (DLS), RP-HPLC and SDS-PAGE analyses. CD measurement showed that interaction between Rusvikunin and Rusvikunin-II did not change their overall secondary structure; however, the protein complex exhibited enhanced hydrodynamic diameter and anticoagulant activity as compared to the individual components of the complex. This study may lay the foundation for understanding the basis of protein complexes in snake venoms and their role in pathophysiology of snakebite.

  6. De novo IGF2 mutation on the paternal allele in a patient with Silver-Russell syndrome and ectrodactyly.

    Science.gov (United States)

    Yamoto, Kaori; Saitsu, Hirotomo; Nakagawa, Norio; Nakajima, Hisakazu; Hasegawa, Tatsuji; Fujisawa, Yasuko; Kagami, Masayo; Fukami, Maki; Ogata, Tsutomu

    2017-08-01

    Although paternally expressed IGF2 is known to play a critical role in placental and body growth, only a single mutation has been found in IGF2. We identified, through whole-exome sequencing, a de novo IGF2 indel mutation leading to frameshift (NM_000612.5:c.110_117delinsAGGTAA, p.(Leu37Glnfs*31)) in a patient with Silver-Russell syndrome, ectrodactyly, undermasculinized genitalia, developmental delay, and placental hypoplasia. Furthermore, we demonstrated that the mutation resided on the paternal allele by sequencing the long PCR product harboring the mutation- and methylation-sensitive SmaI and SalI sites before and after SmaI/SalI digestion. The results, together with the previous findings in four cases from a single family with a paternally inherited IGF2 nonsense mutation and those in patients with variable H19 differentially methylated region epimutations leading to compromised IGF2 expression, suggest that the whole phenotype of this patient is explainable by the IGF2 mutation, and that phenotypic severity is primarily determined by the IGF2 expression level in target tissues. © 2017 Wiley Periodicals, Inc.

  7. Silver-Russell syndrome due to maternal uniparental disomy 7 and a familial reciprocal translocation t(7;13).

    Science.gov (United States)

    Behnecke, A; Hinderhofer, K; Jauch, A; Janssen, J W G; Moog, U

    2012-11-01

    Silver-Russell syndrome (SRS) is a genetically heterogeneous disorder characterized by intrauterine and postnatal growth retardation, typical facial features and a spectrum of additional features including body and limb asymmetry and clinodactyly. Maternal uniparental disomy for chromosome 7 (upd(7)mat) was shown to occur in 5-10% of patients with SRS. Maternal UPD7 is clinically often associated with mild SRS. Parents of an affected child are given a negligible recurrence risk as all reported cases with upd(7)mat have been sporadic so far. In general, chromosomal rearrangements-like translocations increase the likelihood of uniparental disomy (UPD) for the chromosomes involved. However, SRS as the result of a upd(7)mat in association with an inherited chromosomal translocation involving chromosome 7 has only been reported once before. Here, we describe the second case of SRS with upd(7)mat due to a familial reciprocal translocation t(7;13). This emphasizes the importance of chromosome analysis in SRS patients with upd(7)mat to rule out chromosomal rearrangements despite their rare occurrence as they are of great relevance for genetic counseling of SRS families.

  8. Trisomy 7 mosaicism prenatally misdiagnosed and maternal uniparental disomy in a child with pigmentary mosaicism and Russell- Silver syndrome.

    Science.gov (United States)

    Petit, F; Holder-Espinasse, M; Duban-Bedu, B; Bouquillon, S; Boute-Benejean, O; Bazin, A; Rouland, V; Manouvrier-Hanu, S; Delobel, B

    2012-03-01

    Prenatal diagnosis of true mosaic trisomy 7 is rare in amniotic fluid and can be misinterpreted as pseudomosaic. The phenotype is highly variable and may be modified by a maternal uniparental disomy of chromosome 7 leading to mild Russell-Silver syndrome (RSS). We report here the third postnatal case of mosaic trisomy 7 with maternal uniparental disomy of chromosome 7 in a boy presenting a mild RSS. Fetal karyotype performed in amniocentesis for intrauterine growth retardation was considered normal. Mosaic trisomy 7 was diagnosed after birth, on fibroblasts karyotype performed for blaschkolinear pigmentary skin anomalies and failure to thrive. Maternal uniparental disomy of chromosome 7 was observed in blood sample. Retrospectively, trisomic 7 cells were identified in one prenatal long-term flask culture revealing a prenatal diagnosis failure. This report emphasizes the difficulty of assessing fetal mosaicism and distinguishing it from pseudomosaicism in cultured amniocytes. It is important to search for uniparental disomy as an indirect clue of trisomy 7 mosaicism and a major prognosis element. Although there are only few prenatal informative cases, detection of trisomy 7 in amniocentesis appears to be associated with a relatively good outcome when maternal uniparental disomy has been ruled out.

  9. A modeling study of the effect of runoff variability on the effective pressure beneath Russell Glacier, West Greenland

    Science.gov (United States)

    Fleurian, Basile; Morlighem, Mathieu; Seroussi, Helene; Rignot, Eric; Broeke, Michiel R.; Kuipers Munneke, Peter; Mouginot, Jeremie; Smeets, Paul C. J. P.; Tedstone, Andrew J.

    2016-10-01

    Basal sliding is a main control on glacier flow primarily driven by water pressure at the glacier base. The ongoing increase in surface melting of the Greenland Ice Sheet warrants an examination of its impact on basal water pressure and in turn on basal sliding. Here we examine the case of Russell Glacier, in West Greenland, where an extensive set of observations has been collected. These observations suggest that the recent increase in melt has had an equivocal impact on the annual velocity, with stable flow on the lower part of the drainage basin but accelerated flow above the Equilibrium Line Altitude (ELA). These distinct behaviors have been attributed to different evolutions of the subglacial draining system during and after the melt season. Here we use a high-resolution subglacial hydrological model forced by reconstructed surface runoff for the period 2008 to 2012 to investigate the cause of these distinct behaviors. We find that the increase in meltwater production at low elevation yields a more efficient drainage system compatible with the observed stagnation of the mean annual flow below the ELA. At higher elevation, the model indicates that the drainage system is mostly inefficient and is therefore strongly sensitive to an increase in meltwater availability, which is consistent with the observed increase in ice velocity.

  10. Pathogenicity, Ovicidal Action, and Median Lethal Concentrations (LC50 of Entomopathogenic Fungi against Exotic Spiralling Whitefly, Aleurodicus dispersus Russell

    Directory of Open Access Journals (Sweden)

    Boopathi Thangavel

    2013-01-01

    Full Text Available Biological control using entomopathogenic fungi could be a promising alternative to chemical control. Entomopathogenic fungi, Beauveria bassiana (Balsamo Vuillemin, Metarhizium anisopliae (Metschnikoff Sorokin, Lecanicillium lecanii (Zimmerm. Zare and Gams, and Paecilomyces fumosoroseus (Wize Brown and Smith, were tested for their pathogenicity, ovicidal effect, and median lethal concentrations (LC50 against exotic spiralling whitefly, Aleurodicus dispersus Russell. The applications were made at the rate of 2 × 109 conidia mL−1 for evaluating the pathogenicity and ovicidal effect of entomopathogenic fungi against A. dispersus. The results of pathogenicity test showed that P. fumosoroseus (P1 strain was highly pathogenic to A. dispersus recording 100% mortality at 15 days after treatment (DAT. M. anisopliae (M2 strain had more ovicidal effect causing 37.3% egg mortality at 8 DAT. However, L. lecanii (L1 strain caused minimum egg hatchability (23.2% at 10 DAT as compared to control (92.6%. The lowest LC50 produced by P. fumosoroseus (P1 strain as 8.189 × 107 conidia mL−1 indicated higher virulence against A. dispersus. Hence, there is potential for use of entomopathogenic fungi in the field conditions as an alternate control method in combating the insect pests and other arthropod pests since they are considered natural mortality agents and are environmentally safe.

  11. Imprinted anomalies in fetal and childhood growth disorders: the model of Russell-Silver and Beckwith-Wiedemann syndromes.

    Science.gov (United States)

    Netchine, Irène; Rossignol, Sylvie; Azzi, Salah; Brioude, Fréderic; Le Bouc, Yves

    2012-01-01

    Fetal growth is a complex process. Its restriction is associated with morbidity and long term metabolic consequences. Imprinted genes have a critical role in mammalian fetal growth. The human chromosome 11p15 encompasses two imprinted domains regulated by their own differentially methylated region (DMR), also called Imprinted Control Region (ICR1 at the H19/IGF-2 domain, paternally methylated), and ICR2 at the KCNQ1/CDKN1C domain (maternally methylated). Loss of imprinting at these two domains is implicated in two growth disorders clinically opposite. A loss of DNA methylation (LOM) at ICR1 is identified in over 50% of patients with Russell-Silver syndrome (RSS), characterized by intrauterine and postnatal growth retardation, spared cranial growth, frequent body asymmetry and severe feeding difficulties. Inversely, a gain of methylation at ICR1 is found in 10% of patients with Beckwith-Wiedemann syndrome (BWS), an overgrowth syndrome with an enhanced childhood tumor risk. We have identified over 150 RSS patients with 11p15 LOM allowing long-term follow-up studies and proposal of clinical guidelines. We also found that ∼10% of RSS patients and ∼25% of BWS patients have multilocus LOM at imprinted regions other than ICR1 or ICR2 11p15, respectively. Recent studies have identified cis-acting regulatory elements and trans-acting factors involved in the regulation of 11p15 imprinting, establishing new potential mechanisms of RSS and BWS.

  12. Commentary: ADHD and social disadvantage: an inconvenient truth? --a reflection on Russell et al. () and Larsson et al. ().

    Science.gov (United States)

    Nigg, Joel T; Craver, Lindsay

    2014-05-01

    In the 1950's, many experts believed hyperkinesis was a neurotic reaction to inner conflicts arising from early family experiences. In the 1990's, many experts believed ADHD to be 'genetic' (without a mechanistic explanation of what that meant). Both views appear naïve today in a scientific world grappling with the complexity of highly plastic gene expression, gene x environment interplay, and epigenetic, context-dependent emergence of psychopathology. Both views also fail to account for the uncomfortable fact that ADHD is also associated with social disadvantage - a level of analysis required in a developmental psychopathology approach. That developmental psychopathology approach, pioneered a generation ago, initially emphasized the accumulation of risk and protective factors, and emerged in a contemporary systemic approach that seeks to determine whether it is risk accumulation (e.g., allostatic load) or specific risk factors (e.g., family process) that mechanistically shape psychopathology. Despite the prominence of the developmental psychopathology perspective, the social context of ADHD is surprisingly neglected today. Both Russell et al. (this issue, 2014) and Larsson et al. (this issue, 2014) take strides toward remedying this state of affairs. © 2014 The Authors. Journal of Child Psychology and Psychiatry. © 2014 Association for Child and Adolescent Mental Health.

  13. Alfred Russel Wallace (1823-1913): the forgotten co-founder of the Neo-Darwinian theory of biological evolution.

    Science.gov (United States)

    Kutschera, Ulrich; Hossfeld, Uwe

    2013-12-01

    The British naturalist Alfred Russel Wallace (1823-1913), who had to leave school aged 14 and never attended university, did extensive fieldwork, first in the Amazon River basin (1848-1852) and then in Southeast Asia (1854-1862). Based on this experience, and after reading the corresponding scientific literature, Wallace postulated that species were not created, but are modified descendants of pre-existing varieties (Sarawak Law paper, 1855). Evolution is brought about by a struggle for existence via natural selection, which results in the adaptation of those individuals in variable populations who survive and reproduce (Ternate essay, 1858). In his monograph Darwinism (1889), and in subsequent publications, Wallace extended the contents of Darwin's Origin of Species (1859) into the Neo-Darwinian theory of biological evolution, with reference to the work of August Weismann (1834-1914). Wallace also became the (co)-founder of biogeography, biodiversity research, astrobiology and evolutionary anthropology. Moreover, he envisioned what was later called the anthropocene (i.e., the age of human environmental destructiveness). However, since Wallace believed in atheistic spiritualism and mixed up scientific facts and supernatural speculations in some of his writings, he remains a controversial figure in the history of biology.

  14. Engaging with Lyell: Alfred Russel Wallace's Sarawak Law and Ternate papers as reactions to Charles Lyell's Principles of Geology.

    Science.gov (United States)

    Costa, J T

    2013-12-01

    Alfred Russel Wallace (1823-1913) and Charles Darwin (1809-1882) are honored as the founders of modern evolutionary biology. Accordingly, much attention has focused on their relationship, from their independent development of the principle of natural selection to the receipt by Darwin of Wallace's essay from Ternate in the spring of 1858, and the subsequent reading of the Wallace and Darwin papers at the Linnean Society on 1 July 1858. In the events of 1858 Wallace and Darwin are typically seen as central players, with Darwin's friends Charles Lyell (1797-1875) and Joseph Dalton Hooker (1817-1911) playing supporting roles. This narrative has resulted in an under-appreciation of a more central role for Charles Lyell as both Wallace's inspiration and foil. The extensive anti-transmutation arguments in Lyell's landmark Principles of Geology were taken as the definitive statement on the subject. Wallace, in his quest to solve the mystery of species origins, engaged with Lyell's arguments in his private field notebooks in a way that is concordant with his engagement with Lyell in the 1855 and 1858 papers. I show that Lyell was the object of Wallace's Sarawak Law and Ternate papers through a consideration of the circumstances that led Wallace to send his Ternate paper to Darwin, together with an analysis of the material that Wallace drew upon from the Principles. In this view Darwin was, ironically, intended for a supporting role in mediating Wallace's attempted dialog with Lyell.

  15. Pathogenicity, Ovicidal Action, and Median Lethal Concentrations (LC 50 ) of Entomopathogenic Fungi against Exotic Spiralling Whitefly, Aleurodicus dispersus Russell.

    Science.gov (United States)

    Thangavel, Boopathi; Palaniappan, Karuppuchamy; Manickavasagam Pillai, Kalyanasundaram; Subbarayalu, Mohankumar; Madhaiyan, Ravi

    2013-01-01

    Biological control using entomopathogenic fungi could be a promising alternative to chemical control. Entomopathogenic fungi, Beauveria bassiana (Balsamo) Vuillemin, Metarhizium anisopliae (Metschnikoff) Sorokin, Lecanicillium lecanii (Zimmerm.) Zare and Gams, and Paecilomyces fumosoroseus (Wize) Brown and Smith, were tested for their pathogenicity, ovicidal effect, and median lethal concentrations (LC50) against exotic spiralling whitefly, Aleurodicus dispersus Russell. The applications were made at the rate of 2 × 10(9) conidia mL(-1) for evaluating the pathogenicity and ovicidal effect of entomopathogenic fungi against A. dispersus. The results of pathogenicity test showed that P. fumosoroseus (P1 strain) was highly pathogenic to A. dispersus recording 100% mortality at 15 days after treatment (DAT). M. anisopliae (M2 strain) had more ovicidal effect causing 37.3% egg mortality at 8 DAT. However, L. lecanii (L1 strain) caused minimum egg hatchability (23.2%) at 10 DAT as compared to control (92.6%). The lowest LC50 produced by P. fumosoroseus (P1 strain) as 8.189 × 10(7) conidia mL(-1) indicated higher virulence against A. dispersus. Hence, there is potential for use of entomopathogenic fungi in the field conditions as an alternate control method in combating the insect pests and other arthropod pests since they are considered natural mortality agents and are environmentally safe.

  16. Understanding Russell's viper venom factor V activator's substrate specificity by surface plasmon resonance and in-silico studies.

    Science.gov (United States)

    Yadav, Pradeep K; Antonyraj, Christian B; Basheer Ahamed, Syed Ibrahim; Srinivas, Sistla

    2017-01-01

    Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546). Russell's viper venom factor V activator (RVV-V) is a thrombin-like serine proteinase that activates FV with selective, single cleavage at site III. A long lasting effort is being pending in understanding the 'selective' binding specificity of the RVV-V towards site III. Here, we present the binding kinetic study of RVV-V with two designed peptides corresponding to the regions from site I (Gln699-Asn713) and site II (1008Lys-Pro1022), respectively, that include 15 amino acids. Our investigation for justifying the binding efficacy and kinetics of peptides includes SPR method, protein-peptide docking, molecular dynamics simulation, and principal component analysis (PCA). Surprisingly, the SPR experiment disclosed that the Peptide II showed a lower binding affinity with KD of 2.775 mM while the Peptide I showed none. Docking and simulation of both the peptides with RVV-V engaged either rooted or shallow binding for Peptide II and Peptide I respectively. The peptide binding resulted in global conformational changes in the native fold of RVV-V, whereas the similar studies for thrombin failed to make major changes in the native fold. In support, the PCA analysis for RVV-V showed the dislocation of catalytic triad upon binding both the peptides. Hence, RVV-V, a serine protease, is incompetent in cleaving these two sites. This study suggests a transition in RVV-V from the native rigid to the distorted flexible structure and paves a way to design a new peptide substrate/inhibitor.

  17. Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.

    Directory of Open Access Journals (Sweden)

    Oliver P Forman

    Full Text Available Spinocerebellar ataxia (SCA in the Parson Russell Terrier (PRT dog breed is a disease of progressive incoordination of gait and loss of balance. Clinical signs usually become notable between 6 and 12 months of age with affected dogs presenting with symmetric spinocerebellar ataxia particularly evident in the pelvic limbs. The degree of truncal ataxia, pelvic limb hypermetria and impaired balance is progressive, particularly during the initial months of disease. A certain degree of stabilisation as well as intermittent worsening may occur. At the later stages of the disease ambulation often becomes difficult, with owners often electing to euthanise affected dogs on welfare grounds. Using a GWAS approach and target-enriched massively-parallel sequencing, a strongly associated non-synonymous SNP in the CAPN1 gene, encoding the calcium dependent cysteine protease calpain1 (mu-calpain, was identified. The SNP is a missense mutation causing a cysteine to tyrosine substitution at residue 115 of the CAPN1 protein. Cysteine 115 is a highly conserved residue and forms a key part of a catalytic triad of amino acids that are crucial to the enzymatic activity of cysteine proteases. The CAPN1 gene shows high levels of expression in the brain and nervous system and roles for the protein in both neuronal necrosis and maintenance have been suggested. Given the functional implications and high level of conservation observed across species, the CAPN1 variant represents a provocative candidate for the cause of SCA in the PRT and a novel potential cause of ataxia in humans.

  18. Prenatal molecular testing for Beckwith-Wiedemann and Silver-Russell syndromes: a challenge for molecular analysis and genetic counseling.

    Science.gov (United States)

    Eggermann, Thomas; Brioude, Frédéric; Russo, Silvia; Lombardi, Maria P; Bliek, Jet; Maher, Eamonn R; Larizza, Lidia; Prawitt, Dirk; Netchine, Irène; Gonzales, Marie; Grønskov, Karen; Tümer, Zeynep; Monk, David; Mannens, Marcel; Chrzanowska, Krystyna; Walasek, Malgorzata K; Begemann, Matthias; Soellner, Lukas; Eggermann, Katja; Tenorio, Jair; Nevado, Julián; Moore, Gudrun E; Mackay, Deborah Jg; Temple, Karen; Gillessen-Kaesbach, Gabriele; Ogata, Tsutomu; Weksberg, Rosanna; Algar, Elizabeth; Lapunzina, Pablo

    2016-06-01

    Beckwith-Wiedemann and Silver-Russell syndromes (BWS/SRS) are two imprinting disorders (IDs) associated with disturbances of the 11p15.5 chromosomal region. In BWS, epimutations and genomic alterations within 11p15.5 are observed in >70% of patients, whereas in SRS they are observed in about 60% of the cases. In addition, 10% of the SRS patients carry a maternal uniparental disomy of chromosome 7 11p15.5. There is an increasing demand for prenatal testing of these disorders owing to family history, indicative prenatal ultrasound findings or aberrations involving chromosomes 7 and 11. The complex molecular findings underlying these disorders are a challenge not only for laboratories offering these tests but also for geneticists counseling affected families. The scope of counseling must consider the range of detectable disturbances and their origin, the lack of precise quantitative knowledge concerning the inheritance and recurrence risks for the epigenetic abnormalities, which are hallmarks of these developmental disorders. In this paper, experts in the field of BWS and SRS, including members of the European network of congenital IDs (EUCID.net; www.imprinting-disorders.eu), put together their experience and work in the field of 11p15.5-associated IDs with a focus on prenatal testing. Altogether, prenatal tests of 160 fetuses (122 referred for BWS, 38 for SRS testing) from 5 centers were analyzed and reviewed. We summarize the current knowledge on BWS and SRS with respect to diagnostic testing, the consequences for prenatal genetic testing and counseling and our cumulative experience in dealing with these disorders.

  19. Diagnosis of Russell-Silver syndrome by the combined bisulfite restriction analysis-denaturing high-performance liquid chromatography assay.

    Science.gov (United States)

    Hattori, Mitsu; Torii, Chiharu; Yagihashi, Tatsuhiko; Izumi, Kosuke; Suda, Naoto; Ohyama, Kimie; Takahashi, Takao; Moriyama, Keiji; Kosaki, Kenjiro

    2009-10-01

    Russell-Silver syndrome (RSS) is characterized by prenatal and postnatal growth retardation, triangular facies, and fifth-finger clinodactyly. Half of all patients with RSS have hypomethylation of the differentially methylated region of the H19 gene on chromosome 11p15.5. Hence, a quantitative methylation analysis of this region can be useful for the molecular diagnosis of RSS. However, conventional assays based on bisulfite clone sequencing are rather time and labor consuming and are not suitable for clinical use. In the present study, we investigated a possible method of quantitatively determining H19 hypomethylation in RSS patients using a combined bisulfite restriction analysis (COBRA)-denaturing high-performance liquid chromatography (DHPLC) assay; in this combined assay, polymerase chain reaction products amplified from the H19 differentially methylated region of bisulfite-treated genomic DNA were analyzed using a COBRA assay, which detects methylation-dependent sequence differences in the bisulfite-treated genomic DNA using a restriction enzyme analysis. We designed the assay so that a restriction enzyme (HinfI) would cut the methylated, but not the unmethylated, template. The molar ratio between the cut and uncut fragments was measured using DHPLC, and the construction of a calibration curve enabled the methylation index for the original genomic DNA to be estimated. An analysis of seven RSS patients using the COBRA-DHPLC assay demonstrated that three of the seven RSS patients had a low methylation index of around 10%. A comparison of the methylation indices obtained using COBRA-DHPLC and conventional bisulfite clone sequencing revealed an excellent intermethod agreement. In summary, we have developed a robust, rapid, and cost-effective COBRA-DHPLC-based screening system for RSS.

  20. Distúrbio de leitura e escrita na Síndrome de Silver-Russell - doi:10.5020/18061230.2006.p113

    Directory of Open Access Journals (Sweden)

    Renata Cavalcante Barbosa

    2012-01-01

    Full Text Available A síndrome de Silver-Russell constitui uma rara doença genética. O seu fenótipo clássico inclui retardo no crescimento intra-uterino e pós-natal, hemihipertrofia, assimetria lateral, assimetria de membros, clinodactilia do quinto dedo da mão e um número variável de dismorfismos faciais, entre eles a desproporção craniofacial e a face triangular. A descrição de suas manifestações fonoaudiológicas, além de escassa, enfatiza aspectos craniofaciais e orais em detrimento dos comprometimentos de leitura e escrita. O objetivo deste estudo foi relatar o caso de uma garota de 14 anos de idade com a Síndrome de Silver-Russell, a qual, após ser submetida a: Teste Illinois de Habilidades Psicolingüísticas; Prova da Consciência Fonológica; Prova de Leitura e Escrita e Teste de Desempenho Escolar, teve diagnóstico fonoaudiológico de Distúrbio de Leitura e Escrita (DLE. Os dados da avaliação evidenciaram a presença de prejuízo na modalidade escrita da linguagem, determinado primordialmente por déficit no processamento fonológico. Com base nos achados, sugerese a realização de avaliação das habilidades de memória fonológica, consciência fonológica e acesso ao léxico mental em crianças com Síndrome de Silver-Russell, durante o período pré-escolar, com o intuito de impedir a instalação e o agravamento de comprometimentos da linguagem escrita.

  1. Indians, blacks and mixed to beyond of the Amazon landscape: the building of local experience in ethnographic notes of the work of Alfred Russel Wallace (1850-1852

    Directory of Open Access Journals (Sweden)

    Victor R. L. Silva

    2016-12-01

    Full Text Available The article reflects on the scientific travels in the Imperial Brazil, highlighting the path way of Alfred Russel Wallace through rivers and equatorial forests of the Amazon valley, and the varied cultural events that took place in this collecting journey. Becomes important the emphasis given to the descriptions of indians and black people of his view, and the analysis of the characteristics and recurrences of this view in comparison of nineteenth-century thought, and in order to break, dissension and creativity.

  2. Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.

    Science.gov (United States)

    Van De Pette, Matthew; Tunster, Simon J; McNamara, Grainne I; Shelkovnikova, Tatyana; Millership, Steven; Benson, Lindsay; Peirson, Stuart; Christian, Mark; Vidal-Puig, Antonio; John, Rosalind M

    2016-03-01

    The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations reported in these patients and the lack of suitable animal models to test the contribution of specific gene alterations. Some genetic alterations suggest a role for increased dosage of the imprinted CYCLIN DEPENDENT KINASE INHIBITOR 1C (CDKN1C) gene, often mutated in IMAGe Syndrome and Beckwith-Wiedemann Syndrome (BWS). Cdkn1c encodes a potent negative regulator of fetal growth that also regulates placental development, consistent with a proposed role for CDKN1C in these complex childhood growth disorders. Here, we report that a mouse modelling the rare microduplications present in some SRS patients exhibited phenotypes including low birth weight with relative head sparing, neonatal hypoglycemia, absence of catch-up growth and significantly reduced adiposity as adults, all defining features of SRS. Further investigation revealed the presence of substantially more brown adipose tissue in very young mice, of both the classical or canonical type exemplified by interscapular-type brown fat depot in mice (iBAT) and a second type of non-classic BAT that develops postnatally within white adipose tissue (WAT), genetically attributable to a double dose of Cdkn1c in vivo and ex-vivo. Conversely, loss-of-function of Cdkn1c resulted in the complete developmental failure of the brown adipocyte lineage with a loss of markers of both brown adipose fate and function. We further show that Cdkn1c is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT. This study reveals a key requirement for Cdkn1c in the early development of the brown adipose lineages. Importantly, active BAT consumes high amounts of energy to

  3. The reliability of age measurements for Young Stellar Objects from Hertzsprung-Russell or color-magnitude diagrams

    Institute of Scientific and Technical Information of China (English)

    Thomas Preibisch

    2012-01-01

    The possibility to estimate ages and masses of Young Stellar Objects (YSOs) from their location in the Hertzsprung-Russell diagram (HRD) or a colormagnitude diagram provides a very important tool for the investigation of fundamental questions related to the processes of star formation and early stellar evolution.Age estimates are essential for studies of the temporal evolution of circumstellar material around YSOs and the conditions for planet formation.The characterization of the age distribution of the YSOs in a star forming region allows researchers to reconstruct the star formation history and provides important information on the fundamental question of whether star formation is a slow or a fast process.However,the reliability of these age measurements and the ability to detect possible age spreads in the stellar population of star forming regions are fundamentally limited by several factors.The variability of YSOs,unresolved binary components,and uncertainties in the calibrations of the stellar parameters cause uncertainties in the derived luminosities that are usually much larger than the typical photometry errors.Furthermore,the pre-main sequence evolution track of a YSO depends to some degree on the initial conditions and the details of its individual accretion history.I discuss how these observational and model uncertainties affect the derived isochronal ages,and demonstrate how neglecting or underestimating these uncertainties can easily lead to severe misinterpretations,gross overestimates of the age spread,and ill-based conclusions about the star formation history.These effects are illustrated by means of Monte-Carlo simulations of observed star clusters with realistic observational uncertainties.The most important points are as follows.First,the observed scatter in the HRD must not be confused with a genuine age spread,but is always just an upper limit to the true age spread.Second,histograms of isochronal ages naturally show a decreasing number of

  4. Nuclear planetology: understanding habitable planets as Galactic bulge stellar remnants (black dwarfs) in a Hertzsprung-Russell (HR) diagram

    Science.gov (United States)

    Roller, Goetz

    2016-04-01

    The Hertzsprung-Russell (HR) diagram is one of the most important diagrams in astronomy. In a HR diagram, the luminosity of stars and/or stellar remnants (white dwarf stars, WD's), relative to the luminosity of the sun, is plotted versus their surface temperatures (Teff). The Earth shows a striking similarity in size (radius ≈ 6.370 km) and Teff of its outer core surface (Teff ≈ 3800 K at the core-mantle-boundary) with old WD's (radius ≈ 6.300 km) like WD0346+246 (Teff ≈ 3820 K after ≈ 12.7 Ga [1]), which plot in the HR diagram close to the low-mass extension of the stellar population or main sequence. In the light of nuclear planetology [2], Earth-like planets are regarded as old, down-cooled and differentiated black dwarfs (Fe-C BLD's) after massive decompression, the most important nuclear reactions involved being 56Fe(γ,α)52Cr (etc.), possibly responsible for extreme terrestrial glaciations events ("snowball" Earth), together with (γ,n), (γ,p) and fusion reactions like 12C(α,γ)16O. The latter reaction might have caused oxidation of the planet from inside out. Nuclear planetology is a new research field, tightly constrained by a coupled 187Re-232Th-238U systematics. By means of nuclear/quantum physics and taking the theory of relativity into account, it aims at understanding the thermal and chemical evolution of Fe-C BLD's after gravitational contraction (e.g. Mercury) or Fermi-pressure controlled collapse (e.g. Earth) events after massive decompression, leading possibly to an r-process event, towards the end of their cooling period [2]. So far and based upon 187Re-232Th-238U nuclear geochronometry, the Fe-C BLD hypothesis can successfully explain the global terrestrial MORB 232Th/238U signature [3]. Thus, it may help to elucidate the DM (depleted mantle), EMI (enriched mantle 1), EMII (enriched mantle 2) or HIMU (high U/Pb) reservoirs, and the 187Os/188Os isotopic dichotomy in Archean magmatic rocks and sediments [4]. Here I present a conceptual

  5. Study of Correlation of Logging Parameters Obtained from the Wells Drilled on Two Nearby Areas with the Same Geological Structure. An Example of Counties Russell and Ellis, Kansas State, USA

    Directory of Open Access Journals (Sweden)

    P. R. Shiryaev

    2016-12-01

    Full Text Available Based on the data shared by Kansas geological survey, the analysis of logging parameters from the wells located in nearby Counties Russell and Ellis located in the Kansas State, USA was performed. These counties have the similar geological structure. Data obtained in Kansas geological survey were processed to delete the gaps and other inconsistent readings. Then the correlation matrixes were calculated showing correlation between shallow, medium and deep logging in each well. Correlation matrixes demonstrated significant correlation between medium and deep logging, and medium and shallow logging because of similar geological structure. Ellis County is located at higher elevation than Russell County hence well top in Ellis County is at the higher elevation than well top in Russell County. We determined the depth shift, for which the maximum correlation between logging parameters in both wells (in Russell and Ellis Counties was observed. In addition, the correlation coefficients for the same logging parameters in two wells were received. The strongest correlation coefficient of up to 0.425 was obtained between medium logging in two wells. The results of study show that if the geological structures are similar the logging parameters obtained from the wells in these areas are also similar.

  6. Estudio clínico, citogenético y molecular en pacientes con el síndrome de Russell- Silver

    Directory of Open Access Journals (Sweden)

    Gabriel Bedoya Berrío

    2001-04-01

    Full Text Available El síndrome de Russel Silver (SRS fue descrito independientemente por Silver y colaboradores en 1953 (1 y por Russell en 1954 (2. Silver hizo énfasis en la asimetría esquelética como característica del trastorno. Russel observó que esta característica era variable en los pacientes que examinó. El diagnóstico clínico incluye un severo retraso en el crecimiento pre y postnatal, características dismórficas incluyendo cara triangular, frente amplia, mandíbula pequeña y comisuras
    labiales hacia abajo (3,4.
    Recientes descubrimientos de disomía uniparental materna
    (DUPm del cromosoma 7 en el 10% de los pacientes con SRS,
    sugieren la presencia de genes impronta en este cromosoma, cuya mutación es responsable del fenotipo de SRS (5.
    Genes comprometidos: varios genes impronta (PEG1/MEST,
    gamama2- COP, y GBR10 localizados en el cromosoma 7. En pacientes con SRS se han identificado duplicaciones en la región 7p13-p11.2 de origen materno que rodean el gen GBR10. Recientemente, pacientes SRS con DUP de la región 7q31-qter únicamente, han reforzado la evidencia que PG1/MEST o genes adyacentes son críticos.
    Pruebas moleculares: solamente el 10% de los casos clínicos
    presentan un mecanismo de alteración de la impronta (UDPm 7; este análisis de microsatélites requiere las muestras de los padres. Luego de que los genes críticos han sido mapeados, las deleciones y los puntos de mutación pueden identificarse en pacientes que no presentan DUP (6.
    La incidencia de SRS no se conoce y puede estar subestimada.

  7. Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle.

    Science.gov (United States)

    Shenoy, P A; Nipate, S S; Sonpetkar, J M; Salvi, N C; Waghmare, A B; Chaudhari, P D

    2013-05-20

    Piper longum L. fruits have been traditionally used against snakebites in north-eastern and southern region of India. To examine the ability of ethanolic extract of fruits of Piper longum L., Piperaceae (PLE) and piperine, one of the main active principles of Piper longum, to inhibit the Russell's viper (Doboia russelii, Viperidae) snake venom activities. Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine against Russell's viper venom was studied in embryonated fertile chicken eggs, mice and rats by using various models as follows: inhibition of venom lethal action, inhibition of venom haemorrhagic action (in vitro), inhibition of venom haemorrhagic action (in vivo), inhibition of venom necrotizing action, inhibition of venom defibrinogenating action, inhibition of venom induced paw edema, inhibition of venom induced mast cell degranulation, creatine kinase assay and assay for catalase activity. PLE was found to inhibit the venom induced haemorrhage in embryonated fertile chicken eggs. Administration of PLE and piperine significantly (p<0.01) inhibited venom induced lethality, haemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose dependent manner. PLE and piperine also significantly (p<0.01) reduced venom induced mast cell degranulation in rats. Venom induced decrease in catalase enzyme levels in mice kidney tissue and increase in creatine kinase enzyme levels in mice serum were significantly (p<0.01) reversed by administration of both PLE and piperine. PLE possesses good anti-snake venom properties and piperine is one of the compounds responsible for the effective venom neutralizing ability of the plant. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  8. Hypopituitarism following envenoming by Russell's vipers (Daboia siamensis and D. russelii) resembling Sheehan's syndrome: first case report from Sri Lanka, a review of the literature and recommendations for endocrine management.

    Science.gov (United States)

    Antonypillai, C N; Wass, J A H; Warrell, D A; Rajaratnam, H N

    2011-02-01

    Russell's vipers (Daboia russelii and D. siamensis) inhabit 10 South and South East Asian countries. People envenomed by these snakes suffer coagulopathy, bleeding, shock, neurotoxicity, acute kidney injury and local tissue damage leading to severe morbidity and mortality. An unusual complication of Russell's viper bite envenoming in Burma (D. siamensis) and southern India (D. russelii) is hypopituitarism but until now it has not been reported elsewhere. Here, we describe the first case of hypopituitarism following Russell's viper bite in Sri Lanka, review the literature on this subject and make recommendations for endocrine investigation and management. A 49-year-old man was bitten and seriously envenomed by D. russelii in 2005. He was treated with antivenom but although he recovered from the acute effects he remained feeling unwell. Hypopituitarism, with deficiencies of gonadal, steroid and thyroid axes, was diagnosed 3 years later. He showed marked improvement after replacement of anterior pituitary hormones. We attribute his hypopituitarism to D. russelii envenoming. Russell's viper bite is known to cause acute and chronic hypopituitarism and diabetes insipidus, perhaps through deposition of fibrin microthrombi and haemorrhage in the pituitary gland resulting from the action of venom procoagulant enzymes and haemorrhagins. Forty nine cases of hypopituitarism following Russell's viper bite have been described in the English language literature. Patients with acute hypopituitarism may present with hypoglycaemia and hypotension during the acute phase of envenoming. Those with chronic hypopituitarism seem to have recovered from envenoming but present later with features of hypopituitarism. Over 85% of these patients had suffered acute kidney injury immediately after the bite. Steroid replacement in acute hypopituitarism is life saving. All 11 patients with chronic hypopituitarism in whom the outcome of treatment was reported, showed marked improvement with hormone

  9. Can we predict the global magnetic topology of a pre-main sequence star from its position in the Hertzsprung-Russell diagram?

    CERN Document Server

    Gregory, S G; Morin, J; Hussain, G A J; Mayne, N J; Hillenbrand, L A; Jardine, M

    2012-01-01

    ZDI studies have shown that the magnetic fields of T Tauri stars can be significantly more complex than a simple dipole and can vary markedly between sources. We collect and summarize the magnetic field topology information obtained to date and present Hertzsprung-Russell (HR) diagrams for the stars in the sample. Intriguingly, the large scale field topology of a given pre-main sequence (PMS) star is strongly dependent upon the stellar internal structure, with the strength of the dipole component of its multipolar magnetic field decaying rapidly with the development of a radiative core. Using the observational data as a basis, we argue that the general characteristics of the global magnetic field of a PMS star can be determined from its position in the HR diagram. Moving from hotter and more luminous to cooler and less luminous stars across the PMS of the HR diagram, we present evidence for four distinct magnetic topology regimes. Stars with large radiative cores, empirically estimated to be those with a core...

  10. Resister's logic: the anti-vaccination arguments of Alfred Russel Wallace and their role in the debates over compulsory vaccination in England, 1870-1907.

    Science.gov (United States)

    Fichman, Martin; Keelan, Jennifer E

    2007-09-01

    In the 1880s, Alfred Russel Wallace, the celebrated co-discoverer of natural selection, launched himself into the centre of a politicised and polarised debate over the unpopular compulsory vaccination laws in England. Wallace never wavered in his belief that smallpox vaccination was useless and likely dangerous. Six years before his death, the anti-vaccinationists successfully secured a conscience clause that effectively dismantled the compulsory vaccination laws. Several other important Victorian scientists joined Wallace in the fight to repeal compulsory vaccination arguing that widely held views on the effectiveness of vaccination and evidence for immunity were inconclusive in the light of (then) contemporary standards of evidence. This article situates Wallace's anti-vaccination logic within the broader matrix of sociopolitical and cultural reform movements of the late Victorian era. Additionally it provides the first detailed analysis of his critique of vaccination science, in particular the role statistics played in his arguments. In this period, both pro-vaccinationists and anti-vaccinationists invested great efforts in collating and analysing statistical data sets that either supported or refuted the claims of vaccination's effectiveness. While each side presented 'controlled' case studies to support their assertions, without an unambiguous test to measure or demonstrate vaccination's effectiveness, the anti-vaccinationists continued to mount credible statistical critiques of vaccination science.

  11. A case of Silver–Russell syndrome (SRS): multiple pituitary hormone deficiency, lack of H19 hypomethylation and favourable growth hormone (GH) treatment response

    Indian Academy of Sciences (India)

    Zoran S. Gucev; Velibor Tasic; Aleksandra Jancevska; Ilija Kirovski

    2009-08-01

    Hypomethylation of the imprinting control region 1 (ICR1) at the IGF2/H19 locus on 11p15 is linked to Silver–Russell syndrome (SRS) and/or hemihypertrophy. This SRS patient was born in term with weight of 3500 g (50 percentile) and length 48 cm (>1 SD below the mean). He was first noticed at the age of 10 years for short stature (114.5 cm, $-3.85$ SD), relatively normal head circumference, a classic facial phenotype, hemihypertrophy (2.5 cm thinner left arm and leg in comparison to the right, asymmetric face), moderate clinodactyly and striking thinness (BMI of 15.3). At the age of 30, the body asymmetry ameliorated (1 cm thinner left arm and leg than the right), and BMI normalized (20.5 cm). Methylation analysis was performed by bisulphate treatment of DNA samples, radiolabelled PCR amplification, and digestion of the PCR products using restriction enzymes. The patient had normomethylation, and in addition hypopituitarism, with low levels of growth hormone (GH) (provocative testing before the start and after termination of GH treatment), thyroxin, TSH, FSH, LH and testosterone. The GH was given for six years, growth response was satisfactory and he reached an adult height of 166 cm. This is a first report of hypopituitarism in a patient with SRS without H19 hypomethylation. It seems that the lack of hypomethylation in this hypopituitary SRS patient is responsible, at least partly, for the favourable final adult height under GH treatment.

  12. Modeling of subglacial water pressure on Russell glacier, toward a better understanding of the relation between meltwater availability and ice dynamics.

    Science.gov (United States)

    de Fleurian, Basile; Morlighem, Mathieu; Seroussi, Helene; Rignot, Eric

    2016-04-01

    Basal sliding is the main control on outlet glaciers velocity. This sliding is mainly driven by the water pressure at the base of the glaciers. The ongoing increase in surface melt of the Greenland Ice Sheet warrants an examination of its impact on basal water pressure and in turn on basal sliding. Here, we examine the case of Russell glacier, West Greenland, where a remarkably extensive set of observations have been gathered. These observations suggest that the increase in runoff has no impact on the annual velocity on the lower part of the drainage basin, but yield an acceleration of ice flow above the Equilibrium Line Altitude (ELA). It is believed that this two distinct behaviours are due to different evolutions of the subglacial draining system during and after the melt season. We use here a high-resolution new generation subglacial hydrological model forced by reconstructed surface runoff for the period 2008 to 2012 to investigate the possible causes of these distinct behaviours. The model results confirm the existence of two distinct behaviours of the subglacial water pressure, an increase in the mean annual water pressure at high elevation and a stagnation of these same mean annual pressures below the ELA. The increase in meltwater at the lower elevation leads to a more developed efficient drainage system and the overall steadiness of the annual velocities, but, at higher elevation the drainage system remains mainly inefficient and is therefore strongly sensitive to the increase in meltwater availability.

  13. EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders: Silver–Russell and Beckwith–Wiedemann syndrome

    Science.gov (United States)

    Eggermann, Katja; Bliek, Jet; Brioude, Frédéric; Algar, Elizabeth; Buiting, Karin; Russo, Silvia; Tümer, Zeynep; Monk, David; Moore, Gudrun; Antoniadi, Thalia; Macdonald, Fiona; Netchine, Irène; Lombardi, Paolo; Soellner, Lukas; Begemann, Matthias; Prawitt, Dirk; Maher, Eamonn R; Mannens, Marcel; Riccio, Andrea; Weksberg, Rosanna; Lapunzina, Pablo; Grønskov, Karen; Mackay, Deborah JG; Eggermann, Thomas

    2016-01-01

    Molecular genetic testing for the 11p15-associated imprinting disorders Silver–Russell and Beckwith–Wiedemann syndrome (SRS, BWS) is challenging because of the molecular heterogeneity and complexity of the affected imprinted regions. With the growing knowledge on the molecular basis of these disorders and the demand for molecular testing, it turned out that there is an urgent need for a standardized molecular diagnostic testing and reporting strategy. Based on the results from the first external pilot quality assessment schemes organized by the European Molecular Quality Network (EMQN) in 2014 and in context with activities of the European Network of Imprinting Disorders (EUCID.net) towards a consensus in diagnostics and management of SRS and BWS, best practice guidelines have now been developed. Members of institutions working in the field of SRS and BWS diagnostics were invited to comment, and in the light of their feedback amendments were made. The final document was ratified in the course of an EMQN best practice guideline meeting and is in accordance with the general SRS and BWS consensus guidelines, which are in preparation. These guidelines are based on the knowledge acquired from peer-reviewed and published data, as well as observations of the authors in their practice. However, these guidelines can only provide a snapshot of current knowledge at the time of manuscript submission and readers are advised to keep up with the literature. PMID:27165005

  14. EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders: Silver-Russell and Beckwith-Wiedemann syndrome.

    Science.gov (United States)

    Eggermann, Katja; Bliek, Jet; Brioude, Frédéric; Algar, Elizabeth; Buiting, Karin; Russo, Silvia; Tümer, Zeynep; Monk, David; Moore, Gudrun; Antoniadi, Thalia; Macdonald, Fiona; Netchine, Irène; Lombardi, Paolo; Soellner, Lukas; Begemann, Matthias; Prawitt, Dirk; Maher, Eamonn R; Mannens, Marcel; Riccio, Andrea; Weksberg, Rosanna; Lapunzina, Pablo; Grønskov, Karen; Mackay, Deborah Jg; Eggermann, Thomas

    2016-10-01

    Molecular genetic testing for the 11p15-associated imprinting disorders Silver-Russell and Beckwith-Wiedemann syndrome (SRS, BWS) is challenging because of the molecular heterogeneity and complexity of the affected imprinted regions. With the growing knowledge on the molecular basis of these disorders and the demand for molecular testing, it turned out that there is an urgent need for a standardized molecular diagnostic testing and reporting strategy. Based on the results from the first external pilot quality assessment schemes organized by the European Molecular Quality Network (EMQN) in 2014 and in context with activities of the European Network of Imprinting Disorders (EUCID.net) towards a consensus in diagnostics and management of SRS and BWS, best practice guidelines have now been developed. Members of institutions working in the field of SRS and BWS diagnostics were invited to comment, and in the light of their feedback amendments were made. The final document was ratified in the course of an EMQN best practice guideline meeting and is in accordance with the general SRS and BWS consensus guidelines, which are in preparation. These guidelines are based on the knowledge acquired from peer-reviewed and published data, as well as observations of the authors in their practice. However, these guidelines can only provide a snapshot of current knowledge at the time of manuscript submission and readers are advised to keep up with the literature.

  15. A Narrow Segment of Maternal Uniparental Disomy of Chromosome 7q31-qter in Silver-Russell Syndrome Delimits a Candidate Gene Region

    Science.gov (United States)

    Hannula, Katariina; Lipsanen-Nyman, Marita; Kontiokari, Tero; Kere, Juha

    2001-01-01

    Maternal uniparental disomy of chromosome 7 (matUPD7), the inheritance of both chromosomes from only the mother, is observed in ∼10% of patients with Silver-Russell syndrome (SRS). It has been suggested that at least one imprinted gene that regulates growth and development resides on human chromosome 7. To date, three imprinted genes—PEG1/MEST, γ2-COP, and GRB10—have been identified on chromosome 7, but their role in the etiology of SRS remains uncertain. In a systematic screening with microsatellite markers, for matUPD7 cases among patients with SRS, we identified a patient who had a small segment of matUPD7 and biparental inheritance of the remainder of chromosome 7. Such a pattern may be explained by somatic recombination in the zygote. The matUPD7 segment at 7q31-qter extends for 35 Mb and includes the imprinted gene cluster of PEG1/MEST and γ2-COP at 7q32. GRB10 at 7p11.2-p12 is located within a region of biparental inheritance. Although partial UPD has previously been reported for chromosomes 6, 11, 14, and 15, this is the first report of a patient with SRS who has segmental matUPD7. Our findings delimit a candidate imprinted region sufficient to cause SRS. PMID:11112662

  16. Influence of Constant Temperature on Development and Reproduction of Encarsia guadeloupae Viggiani (Hymenoptera: Aphelinidae), a Parasitoid of the Spiraling Whitefly Aleurodicus dispersus Russell (Hemiptera: Aleyrodidae).

    Science.gov (United States)

    Chen, J Y; Niu, L M; Li, L; Han, D Y; Fu, Y G

    2015-04-01

    Encarsia guadeloupae Viggiani is an important parasitoid of Aleurodicus dispersus Russell. The effects of temperature (16, 20, 24, 28, and 32°C) on development and reproduction of this parasitoid on A. dispersus were studied in laboratory experiments. The developmental duration of E. guadeloupae varied from 14.9 (32°C) to 54.4 days (16°C). The developmental threshold and thermal constant for an entire generation were 10.52°C and 308.85 degree-days, respectively. The highest survival rate (63.8%) of immature E. guadeloupae was recorded at 28°C. The average adult longevity ranged from 6.0 (32°C) to 15.1 days (16°C). The highest fecundity was observed at 28°C. The intrinsic rate of increase (r m ), net reproduction rate (R o ), and finite rate of increase (λ) were the highest at 28°C, which were 0.18, 54.25 and 1.21, respectively. We concluded that 28°C is the most suitable temperature for development and reproduction of E. guadeloupae.

  17. Comparative study of anticoagulant and procoagulant properties of 28 snake venoms from families Elapidae, Viperidae, and purified Russell's viper venom-factor X activator (RVV-X).

    Science.gov (United States)

    Suntravat, Montamas; Nuchprayoon, Issarang; Pérez, John C

    2010-09-15

    Snake venoms consist of numerous molecules with diverse biological functions used for capturing prey. Each component of venom has a specific target, and alters the biological function of its target. Once these molecules are identified, characterized, and cloned; they could have medical applications. The activated clotting time (ACT) and clot rate were used for screening procoagulant and anticoagulant properties of 28 snake venoms. Crude venoms from Daboia russellii siamensis, Bothrops asper, Bothrops moojeni, and one Crotalus oreganus helleri from Wrightwood, CA, had procoagulant activity. These venoms induced a significant shortening of the ACT and showed a significant increase in the clot rate when compared to the negative control. Factor X activator activity was also measured in 28 venoms, and D. r. siamensis venom was 5-6 times higher than those of B. asper, B. moojeni, and C. o. helleri from Wrightwood County. Russell's viper venom-factor X activator (RVV-X) was purified from D. r. siamensis venom, and then procoagulant activity was evaluated by the ACT and clot rate. Other venoms, Crotalus atrox and two Naja pallida, had anticoagulant activity. A significant increase in the ACT and a significant decrease in the clot rate were observed after the addition of these venoms; therefore, the venoms were considered to have anticoagulant activity. Venoms from the same species did not always have the same ACT and clot rate profiles, but the profiles were an excellent way to identify procoagulant and anticoagulant activities in snake venoms.

  18. A 1750-1999 AD Atmospheric Record of East Asian Black Carbon Emissions from the Prospector-Russell Col Ice Core, Mt. Logan, Yukon Territory

    Science.gov (United States)

    Menking, J. A.; Kaspari, S.; Osterberg, E. C.; Fisher, D.

    2012-12-01

    Black carbon (BC), an aerosol created from the incomplete combustion of fossil and biofuels, absorbs sunlight causing warming in the atmosphere and cooling at the surface. BC deposited on snow and ice reduces the surface albedo, accelerating seasonal snowmelt and glacier retreat and influencing the regional water cycle and climate. Estimates place East Asia as the top BC producer worldwide. Recent studies suggest that increases in East Asian BC related to industrialization have influenced Asian climate by altering temperatures and the timing and magnitude of precipitation. East Asian BC emissions have been estimated using fossil fuel inventories, but observational data is needed to constrain the timing and magnitude of recent BC emissions changes in order to better assess the role of BC in recent climate change. Here we present a time series of East Asian atmospheric BC that spans 1750-1999 AD that was developed using an ice core collected at the Prospector-Russell (PR) Col on Mt. Logan, Yukon Territory, Canada. The PR Col ice core is ideal for developing a record of East Asian BC emissions because the Mt. Logan summit has been shown to capture Asian emissions transported across the Pacific Ocean. The Mt. Logan record shows increases in BC concentration occurring in the early 1980's related to the recent industrialization of East Asian nations. We utilize the BC record from Mt. Logan (1) for comparison with estimated East Asian emissions inventories, and (2) to assess the role of BC in recent climate change with respect to the timing and magnitude of changes in East Asian BC emissions.

  19. Thin-layer effects in glaciological seismic amplitude-versus-angle (AVA analysis: implications for characterising a subglacial till unit, Russell Glacier, West Greenland

    Directory of Open Access Journals (Sweden)

    A. D. Booth

    2012-08-01

    Full Text Available Seismic amplitude-versus-angle (AVA methods are a powerful means of quantifying the physical properties of subglacial material, but serious interpretative errors can arise when AVA is measured over a thinly-layered substrate. A substrate layer with a thickness less than 1/4 of the seismic wavelength, λ, is considered "thin", and reflections from its bounding interfaces superpose and appear in seismic data as a single reflection event. AVA interpretation of subglacial till can be vulnerable to such thin-layer effects, since a lodged (non-deforming till can be overlain by a thin (metre-scale cap of dilatant (deforming till. We assess the potential for misinterpretation by simulating seismic data for a stratified subglacial till unit, with an upper dilatant layer between 0.1–5.0 m thick (λ / 120 to > λ / 4, with λ = 12 m. For dilatant layers less than λ / 6 thick, conventional AVA analysis yields acoustic impedance and Poisson's ratio that indicate contradictory water saturation. A thin-layer interpretation strategy is proposed, that accurately characterises the model properties of the till unit. The method is applied to example seismic AVA data from Russell Glacier, West Greenland, in which characteristics of thin-layer responses are evident. A subglacial till deposit is interpreted, having lodged till (acoustic impedance = 4.26±0.59 × 106 kg m−2 s−1 underlying a water-saturated dilatant till layer (thickness < 2 m, Poisson's ratio ~ 0.5. Since thin-layer considerations offer a greater degree of complexity in an AVA interpretation, and potentially avoid misinterpretations, they are a valuable aspect of quantitative seismic analysis, particularly for characterising till units.

  20. IGF2/H19 hypomethylation is tissue, cell, and CpG site dependent and not correlated with body asymmetry in adolescents with Silver-Russell syndrome

    Directory of Open Access Journals (Sweden)

    Kannenberg Kai

    2012-09-01

    Full Text Available Abstract Background Silver-Russell syndrome (SRS is characterized by severe intrauterine and postnatal growth failure and frequent body asymmetry. Half of the patients with SRS carry a DNA hypomethylation of the imprinting center region 1 (ICR1 of the insulin-like growth factor 2 (IGF2/H19 locus, and the clinical phenotype is most severe in these patients. We aimed to elucidate the epigenetic basis of asymmetry in SRS and the cellular consequences of the ICR1 hypomethylation. Results The ICR1 methylation status was analyzed in blood and in addition in buccal smear probes and cultured fibroblasts obtained from punch biopsies taken from the two body halves of 5 SRS patients and 3 controls. We found that the ICR1 hypomethylation in SRS patients was stronger in blood leukocytes and oral mucosa cells than in fibroblasts. ICR1 CpG sites were affected differently. The severity of hypomethylation was not correlated to body asymmetry. IGF2 expression and IGF-II secretion of fibroblasts were not correlated to the degree of ICR1 hypomethylation. SRS fibroblasts responded well to stimulation by recombinant human IGF-I or IGF-II, with proliferation rates comparable with controls. Clonal expansion of primary fibroblasts confirmed the complexity of the cellular mosaicism. Conclusions We conclude that the ICR1 hypomethylation SRS is tissue, cell, and CpG site specific. The correlation of the ICR1 hypomethylation to IGF2 and H19 expression is not strict, may depend on the investigated tissue, and may become evident only in case of more severe methylation defects. The body asymmetry in juvenile SRS patients is not related to a corresponding ICR1 hypomethylation gradient, rendering more likely an intrauterine origin of asymmetry. Overall, it may be instrumental to consider not only the ICR1 methylation status as decisive for IGF2/H19 expression regulation.

  1. Biochemical and pharmacological characterization of a toxic fraction and its cytotoxin-like component isolated from Russell's viper (Daboia russelii russelii) venom.

    Science.gov (United States)

    Thakur, Rupamoni; Chattopadhyay, Pronobesh; Mukherjee, Ashis K

    2015-02-01

    The pathophysiological significance of a toxic fraction (GF-VI DEAE-II) isolated from Russell's viper venom (RVV) is characterized. GF-VI DEAE-II represents 1.6% of the total RVV protein and it comprises of a 27.6kDa minor component (RP-I) (0.04%, w/w) and a major 6.6kDa non-enzymatic peptide (1.11%, w/w), named Rusvitoxin. The LC-MS/MS analysis of RP-I showed its identity to snake venom serine proteases, whereas Rusvitoxin demonstrated its close identity with snake venom three finger toxins, cytotoxins and cardiotoxins particularly from Naja sp. GF-VI DEAE-II was found to be non-cytotoxic to the tested mammalian cancer cells and non-hemolytic; nevertheless, it demonstrated α-fibrin(ogen)ase activity and in vivo toxicity in BALB/c mice with an LD50 (i.p.) of 2.3mg/kg. GF-VI DEAE-II induced lethargy and hind-leg paralysis in mice within 10min of i.p. injection. GF-VI DEAE-II induced hyperfibrinogenomia, and significantly altered (p<0.05) the plasma levels of factor X, pro- and anti-inflammatory cytokines viz. TNF-α, IL-6 and IL-10 in treated mice. Histological observations of tissues and biochemical properties of serum from GF-VI DEAE-II-treated mice suggested multiple organ dysfunctions. Conversely, Rusvitoxin at a dose of 5mg/kg did not induce toxicity in BALB/c mice. At 1:15 (antigen: antivenom, w/w) ratio, commercially polyvalent and monovalent antivenoms neutralized more than 80% of the fibrinolytic and anticoagulant activities of GF-VI DEAE-II. The present study suggests the significant role of GF-VI DEAE-II in RVV-induced pathogenesis in victim/prey.

  2. Inhibition of secretary PLA₂--VRV-PL-VIIIa of Russell's viper venom by standard aqueous stem bark extract of Mangifera indica L.

    Science.gov (United States)

    Dhananjaya, B L; Sudarshan, S

    2015-03-01

    The aqueous extract of Mangifera indica is known to possess anti-snake venom activities. However, its inhibitory potency and mechanism of action on multi-toxic phospholipases A2s, which are the most toxic and lethal component of snake venom is still unknown. Therefore, this study was carried out to evaluate the modulatory effect of standard aqueous bark extract of M. indica on VRV-PL-VIIIa of Indian Russells viper venom. Mangifera indica extract dose dependently inhibited the GIIB sPLA2 (VRV-PL-VIIIa) activity with an IC50 value of 6.8±0.3 μg/ml. M. indica extract effectively inhibited the indirect hemolytic activity up to 96% at ~40 μg/ml concentration. Further, M. indica extract at different concentrations (0-50 μg/ml) inhibited the edema formed in a dose dependent manner. It was found that there was no relieve of inhibitory effect of the extract when examined as a function of increased substrate and calcium concentration. The inhibition was irreversible as evident from binding studies. The in vitro inhibition is well correlated with in situ and in vivo edema inducing activities. As the inhibition is independent of substrate, calcium concentration and was irreversible, it can be concluded that M. indica extracts mode of inhibition could be due to direct interaction of components present in the extract with PLA2 enzyme. In conclusion, the aqueous extract of M. indica effectively inhibits svPLA2 (Snake venom phospholipase A2) enzymatic and its associated toxic activities, which substantiate its anti-snake venom properties. Further in-depth studies are interesting to known on the role and mechanism of the principal inhibitory constituents present in the extract, so as to develop them into potent anti-snake venom and as an anti-inflammatory agent.

  3. Activated protein C resistance in patients following venous thromboembolism receiving rivaroxaban versus vitamin K antagonists: assessment using Russell viper venom time-based assay.

    Science.gov (United States)

    Goralczyk, Tadeusz; Wojtowicz, Katarzyna B; Undas, Anetta

    2016-09-15

    Activated protein C resistance (APC-R) is assessed as part of thrombophilia screening, preferably in patients not taking oral anticoagulants. Rivaroxaban is known to alter some APC-R assays. To our knowledge, there have been no reports on the effect of rivaroxaban on the Russell viper venom time (RVVT)-based APC-R assay in real-life patients. In 168 consecutive outpatients suspected of having venous thromboembolism because of thrombophilia, APC-R was determined using the RVVT-based ProC Ac R assay (Siemens, Marburg, Germany). Patients receiving rivaroxaban or vitamin K antagonists were eligible. We measured rivaroxaban concentrations using the anti-Xa Biophen DiXal assay (Hyphen Biomed, Neuville-Sur-Oise, France) and factor V Leiden using the real-time PCR. APC-R was detected in 23 (28%) patients on rivaroxaban (n = 81) administrated 2-48 h since the blood draw, 15 (28%) patients on vitamin K antagonists (n = 54), and in four (12%) patients off anticoagulation (n = 33). Compared with nonanticoagulated patients, APC-R ratios were similar in patients on rivaroxaban, without any correlation with rivaroxaban concentrations (from 0 to 303 μg/l). None of the patients on rivaroxaban were found to have false-negative or false-positive APC-R ratios. Rivaroxaban concentrations up to 300 μg/l do not affect results of the ProC Ac R RVVT-based assay, which could be recommended in patients referred to a clinic for thrombophilia screening in whom the time since the last dose of rivaroxaban is uncertain.

  4. Effects of autism spectrum disorders on outcome in teenage-onset anorexia nervosa evaluated by the Morgan-Russell outcome assessment schedule: a controlled community-based study.

    Science.gov (United States)

    Nielsen, Søren; Anckarsäter, Henrik; Gillberg, Carina; Gillberg, Christopher; Råstam, Maria; Wentz, Elisabet

    2015-01-01

    The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN). The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51 healthy comparison cases. The full multinomial distribution of responses for the full scale and each of the subscales was evaluated using exact nonparametric statistical methods. The impact of diagnostic stability of ASD on outcome in AN was evaluated in a dose-response model. There were no deaths in either group. Food intake and menstrual pattern were initially poor in the AN group but normalised over time. MROAS 'mental state' was much poorer in the AN group and did not improve over time. The psychosexual MROAS domains 'attitudes' and 'aims' showed persistent problems in the AN group. In the MROAS socioeconomic domain, the subscales 'personal contacts', 'social activities' and 'employment record' all showed highly significant between-group differences at all three follow-ups. A statistically significant negative dose-response relationship was found between a stable diagnosis of ASD over time and the results on the subscales 'mental state', 'psychosexual state' and 'socio-economic state'. Outcome of teenage-onset AN is favourable with respect to mortality and persisting eating disorder, but serious problems remain in the domains 'mental state', 'psychosexual function' and 'socioeconomic state'. Outcome is considerably worse if ASD is present. Treatment programmes for AN need to be modified so as to accommodate co-existing ASD.

  5. Yield stability in maize (Zea mays L. and correlations among the parameters of the Eberhart and Russell, Lin and Binns and Huehn models

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Scapim

    2000-06-01

    Full Text Available Assessment of the stability and adaptability of a genotype to different environments is useful for recommending cultivars for known conditions of cultivation and should be a requirement in breeding programs. Twenty maize (Zea mays L. cultivars were tested at eight locations in Minas Gerais by the National Center for Maize and Sorghum Research (CNPMS of the Brazilian Enterprise for Agricultural Research (EMBRAPA for two years. The experiments involved a randomized complete block design in which three procedures were used to analyze cultivar stability and adaptability. The level of association among the parameters obtained by the three methods was assessed using Spearman's rank correlation. Hybrids 'DINA 170', 'G-96C', 'C 505', 'DINA 70' and 'C 435' had a mean yield greater than 6,000 kg/ha. Eberhart and Russell's regression coefficient (betai was negative and correlated significantly (P or = 0.05, but correlated positively with Si(1 (P O conhecimento sobre a estabilidade e adaptabilidade de comportamento de genótipos contém informações muito úteis para a recomendação de cultivares para condições de cultivo conhecidas a priori, de modo que a avaliação da resposta dos genótipos às variações ambientais deve ser etapa obrigatória em programas de melhoramento. Para caracterizar 20 cultivares de milho, foram realizados dez ensaios (oito localidades do Estado de Minas Gerais, em dois anos no delineamento de blocos ao acaso, pelo Centro Nacional de Pesquisa de Milho e Sorgo (CNPMS da Empresa Brasileira de Pesquisa Agropecuária (Embrapa. Três procedimentos estatísticos foram adotados para a análise da estabilidade e adaptabilidade dos cultivares e avaliou-se o grau de associação entre os parâmetros dos três métodos por meio da correlação classificatória de Spearman. 'DINA 170', 'G-96C', 'C 505', 'DINA 70' e 'C 435' destacaram-se com produtividades médias superiores a 6.000 kg/ha. O coeficiente de regressão (betai de Eberhart

  6. Level II scour analysis for Bridge 63 (MTH0TH00120063) on Town Highway 12, crossing Russell Brook, Mount Holly, Vermont

    Science.gov (United States)

    Wild, Emily C.; Severance, Timothy

    1998-01-01

    This report provides the results of a detailed Level II analysis of scour potential at structure MTHOTH00120063 on Town Highway 12 crossing Russell Brook, Mount Holly, Vermont (figures 1–8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (FHWA, 1993). Results of a Level I scour investigation also are included in appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, gleaned from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in appendix D. The site is in the Green Mountain section of the New England physiographic province in south-central Vermont. The 3.6-mi2 drainage area is in a predominantly rural and forested basin. In the vicinity of the study site, the surface cover is forest upstream and downstream of the bridge. In the study area, Russell Brook has an incised, sinuous channel with a slope of approximately 0.0263 ft/ft, an average channel top width of 29 ft and an average bank height of 3 ft. The channel bed material ranges from cobbles to boulders with a median grain size (D50) of 97.1 mm (0.318 ft). The geomorphic assessment at the time of the Level I and Level II site visit on October 4, 1995, indicated that the reach was stable. The Town Highway 12 crossing of Russell Brook is a 29-ft-long, one-lane bridge consisting of a 26-foot steel-stringer span (Vermont Agency of Transportation, written communication, March 21, 1995). The opening length of the structure parallel to the bridge face is 23.5 ft. The bridge is supported by vertical, concrete abutments with wingwalls. The channel is skewed approximately 40 degrees to the opening while the computed opening-skew-to-roadway is 35 degrees. During the Level I assessment, it was observed that the upstream left wingwall footing was exposed 0.2 ft, in reference to

  7. 勒氏笛鲷(Lutjanus russellii)肌肉生长抑制素基因的克隆与分析%Cloning and Analysis of the Myostatin (MSTN) Gene in Russell's Snapper, Lutjanus russellii

    Institute of Scientific and Technical Information of China (English)

    邓思平; 李嘉颖; 张婉玲; 宋春杰; 李广丽; 朱春华; 吴天利

    2011-01-01

    Myostatin (MSTN) gene was isolated from Russell's snapper, Lutjanus russellii by homology cloning method with the genome DNA. The Russell's snapper MSTN was 2887 bp in length, including three exons and two introns, along with 101 bp 5-UTR (untranslated region), 385 bp exon 1, 354 bp intron 1, 370 bp exon 2, 761 bp intron 2, 381 bp exon 3 and 1 932 bp 3'-UTR. The Russell's snapper MSTN gene encodes a 378 amino acid protein, including nine conserved cysteine residues, a RVRR proteolytic cleavage domain, and a putative signal peptide of 22 amino acids. Amino acid sequence analyses show the Russell's snapper MSTN has closer affinity with type 1 MSTN than type 2 MSTN of several telests. And it has the highest identity with Perciformes, higher identity with Cypriniformes, and the least identity with that of mouse, human and chicken MSTN. Neighbor-joining method and the results also show Russell's snapper has the closest homology with morone. And it clusters with type 1 MSTN of fish. It suggests that the Russell's snapper MSTN we isolated may belong to type I MSTN.%以勒氏笛鲷(Lutjanus russellii)基因组DNA为模板,采用同源克隆的方法,获得2887bp的肌肉生长抑制素(myostatin,MSTN)基因组序列,该MSTN序列具有3个外显子和2个内含子,包括101bp的5′-UTR、385bp的外显子1、354bp的内含子1、370bp的外显子2、761bp的内含子2、381bp的外显子3和1932bp的3′-UTR.整个开放阅读框编码了378个氨基酸,前面的22个氨基酸为信号肽,具有9个保守的半胱氨基酸及一个RVRR的蛋白酶解加工位点.氨基酸序列分析发现,该基因编码的蛋白质与其他鱼类的Ⅰ型同源性较高,与其他鱼类的2型MSTN同源性较低,且与鲈形目的同源性最高,与鲤形目的同源性较低,与人、鼠和鸡的同源性最低.采用邻接法(Neighbor-Joining)构建的MSTN的系统发育树表明,勒氏笛鲷MSTN与鲈形目鱼类的狼鲈属亲缘关系较近,且与鱼类的MSTN-1聚为1支.这表明该基因属于Ⅰ型MSTN基因.

  8. 7th February 2011 - Scottish Cabinet Secretary for Education and Lifelong Learning M. Russell MSP signing the guest book with Beams Department Head P. Collier and Adviser J. Ellis

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    01-17:Scottish Cabinet Secretary for Education and Lifelong Learning M. Russell MSP signing the guest book with Beams Department Head P. Collier and Adviser J. Ellis 18-22: Teachers and Pupils signing the guest book 23-27: visiting the CERN control centre with P. Collier 28-32: visiting the LHCb underground area 33-74: visitng the ATLAS underground area Other members of the delegation: Chief Scientific Adviser to the Scottish Government and Chair in Molecular and Cell Biology at the University of Aberdeen A. Glover; Assistant Private Secretary M. Gallagher; Associate Director Institute for Gravitational Research, University of Glasgow J.Hough.

  9. Study on Dimethoate by Trunk Injection Method for the Aleurodicus dispersus Russell Control%树干注射乐果防治螺旋粉虱的研究

    Institute of Scientific and Technical Information of China (English)

    田海; 张扬; 曾东强; 黄超福; 谭辉华

    2011-01-01

    选用20%乐果水乳剂在螺旋粉虱成虫产卵高峰期采用树干注射法进行防治,采用气相色谱法分析了乐果在印度紫檀叶片中的吸收分布.结果表明,采用树干注射法施药,20%乐果水乳剂对螺旋粉虱具有显著的防治效果;乐果在印度紫檀叶片中的含量随着时间的变化先增加后降低,在14d左右达到浓度高峰.%20% Dimethoate EW was selected to be injected in the trunk of the red sandalwood during the oviposition peaks of Aleurodicus dispersus Russell. The dimethoate concentrations in the red sandalwood leaves were analyzed by gas chromatography. The results showed that trunk-injection of dimethoate had remarkable efficacy on controlling of Aleurodicus dispersus Russell. The concentration of dimethoate in the red sandalwood leaves first increased following trunk-injection, then decreased at 14 days.

  10. TERRAIN, RUSSELL COUNTY, KENTUCKY USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  11. BASEMAP, RUSSELL COUNTY, ALABAMA USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  12. HYDRAULICS, Russell COUNTY, KENTUCKY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  13. HYDROLOGY, RUSSELL COUNTY, ALABAMA USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  14. TERRAIN, RUSSELL COUNTY, ALABAMA USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  15. Russell BarkIey父母培训八步法对注意缺陷多动障碍儿童干预的疗效%Effect of eight steps of BarkIey Russell parental training on children with attention deficit hyperactivity disorder

    Institute of Scientific and Technical Information of China (English)

    聂所成; 刘长成; 张新风; 韩刚亚

    2016-01-01

    Objective To study the feasibility and efficacy of BarkIey Russell parent training for children with attention deficit hyperactivity disorder (ADHD).Methods 80 children with ADHD were randomly divided into the study group and the control group.The control group were given routine medication,psychological care,health education.The study group were given the Barkley Russell parent training on the basis of the therapy for the control group.Parent training includes analysis of the reasons for the child's behavior,to give attention and praise,material rewards or punishment,supervision in public places children,and to correct the bad behavior of children in school.Using self-compiled questionnaire and Conners questionnaire,we evaluated the effect in both groups.Results The effective rate of the study group and the control group were 76.92% and 54.05%,respectively,the comparison was statistically significant (P,X2=4.41 < 0.05).After 10 weeks of treatment,the study group was significantly decrease in among conduct problems,learning problems,psychosomatic problems,impulsivity hyperactivity,anxiety,andhyperactivity index (t =7.2825,7.5142,6.9048,2.1560,7.1232,11.4252,P< 0.05),the impulsivity,hyperactivity,anxiety,and hyperactivity index in the control group is significantly decreased (t=2.5992,6.8614,2.8384,P< 0.05) compared with those before treatment;group:after 10 weeks of treatment,study group and the control group were statistically significant in conduct problems,learning problems,psychosomatic problem (t=15.5986,3.9941,3.8795,P<0.05).94.3% of the parents feel that this training on the discipline of the child's help,and this training is introduced to other parents.Conclusion parent training can effectively improve the core symptoms of ADHD children,the parents of the high degree of satisfaction.%目的 研究Russell Barkley父母培训八步法对注意缺陷多动障碍(ADHD)儿童干预的可行性和疗效,为临床干预提供依据.方法 采用80

  16. Killarney Community Hospitals (Fuschia, Hawthorn and Heather Wards), St Margaret's Road, Killarney, Kerry.

    LENUS (Irish Health Repository)

    McNabola, Aonghus

    2009-02-01

    According to World Health Organisation figures, 30% of all cancer deaths, 20% of all coronary heart diseases and strokes and 80% of all chronic obstructive pulmonary disease are caused by cigarette smoking. Environmental Tobacco Smoke (ETS) exposure has also been shown to be associated with disease and premature death in non-smokers. In response to this environmental health issue, several countries have brought about a smoking ban policy in public places and in the workplace. Countries such as the U.S., France, Italy, Ireland, Malta, the Netherlands, Sweden, Scotland, Spain, and England have all introduced policies aimed at reducing the population exposure to ETS. Several investigations have monitored the effectiveness of these smoking ban policies in terms of ETS concentrations, human health and smoking prevalence, while others have also investigated a number of alternatives to smoking ban policy measures. This paper reviews the state of the art in research, carried out in the field of ETS, smoking bans and Tobacco Control to date and highlights the need for future research in the area.

  17. Book Review ~ e-Research: Methods, Strategies, and Issues. Authors: Terry Anderson and Heather Kanuka

    Directory of Open Access Journals (Sweden)

    Reviewed by Christine von Prümmer

    2003-10-01

    Full Text Available The book e-Research: Methods, Strategies, and Issues is a comprehensive introduction to Net-based research, covering all steps of a research project as well as different types of research. True to its title, it also deals with important issues of e-research, focussing especially on the issue of ethics.

  18. In vitro activity of heather [Calluna vulgaris (L.) Hull] extracts on selected urinary tract pathogens

    Science.gov (United States)

    Vučić, Dragana M.; Petković, Miroslav R.; Rodić-Grabovac, Branka B.; Stefanović, Olgica D.; Vasić, Sava M.; Čomić, Ljiljana R.

    2014-01-01

    Calluna vulgaris L. Hull (Ericaceae) has been used for treatment of urinary tract infections in traditional medicine. In this study we analyzed in vitro antibacterial activity of the plant extracts on different strains of Escherichia coli, Enterococcus faecalis and Proteus vulgaris, as well as the concentrations of total phenols and flavonoids in the extracts. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. The concentrations of total phenols were examined by using Folin-Ciocalteu reagent and ranged between 67.55 to 142.46 mg GAE/g. The concentrations of flavonoids in extracts were determined using spectrophotometric method with aluminum chloride and the values ranged from 42.11 to 63.68 mg RUE/g. The aqueous extract of C. vulgaris showed a significant antibacterial activity. The values of MIC were in the range from 2.5 mg/ml to 20 mg/ml for this extract. Proteus vulgaris strains were found to be the most sensitive. The results obtained suggest that all tested extracts of C. vulgaris inhibit the growth of human pathogens, especially the aqueous extract. PMID:25428676

  19. Information Literacy Course Yields Mixed Effects on Undergraduate Acceptance of the University Library Portal Heather Coates

    Directory of Open Access Journals (Sweden)

    Heather Coates

    2016-04-01

    Full Text Available Objective – To determine the effects over time of a 3-credit semester-long undergraduate information literacy course on student perception and use of the library web portal. Design – Mixed methods, including a longitudinal survey and in-person interviews. Setting – Information literacy course at a comprehensive public research institution in the northeastern United States of America. Subjects – Undergraduates at all levels enrolled in a 3-credit general elective information literacy course titled “The Internet and Information Access.” Methods – A longitudinal survey was conducted by administering a questionnaire to students at three different points in time: prior to instruction, near the end of the course (after receiving instruction on the library portal, and three months after the course ended, during the academic year 2011-2012. The survey was created by borrowing questions from several existing instruments. It was tested and refined through pre-pilot and pilot studies conducted in the 2010-2011 academic year, for which results are reported. Participation was voluntary, though students were incentivized to participate through extra credit for completing the pre- and post-instruction questionnaire, and a monetary reward for completing the follow-up questionnaire. Interviews were conducted with a subset of 14 participants at a fourth point in time. Main Results – 239 of the 376 (63.6% students enrolled in the course completed the pre- and post-instruction questionnaire. Fewer than half of those participants (111 or 30% of students enrolled completed the follow-up questionnaire. Participants were primarily sophomores and juniors (32% each, with approximately one-quarter (26% freshman, and only 10% seniors. Student majors were concentrated in the social sciences (62%, with fewer students from science and technology (13%, business (13%, and the humanities (9%. The 14 participants interviewed were drawn from both high- and low-use students. Overall, the course had a positive effect on students’ perception of usefulness (PU and ease of use (PEOU, as well as usage of the library portal. This included significant positive changes in perceived ease of use and information quality in the short-term (from pre-instruction to post-instruction. The results were mixed for perceived usefulness and system quality. Though there was mixed long-term impact on usage, the course does not appear to have had a long-term effect on PU and PEOU. The interview participants were asked questions to explore why and how they used the library portal, and revealed that both high- and low-use students used the library portal for similar reasons: to find information for research papers or projects, to search the library catalogue for books, and in response to a mandate or encouragement from instructors. Conclusion – The study supports the theory that an information literacy course could change student perception and use of the library portal in the short-term. Replicating this design in other settings could provide a systematic approach for assessing whether information literacy courses address learning outcomes over time. A longitudinal approach could be useful for comparing proficiency and information behaviors of those who take information literacy courses with those who do not.

  20. Bertrand Russell's View About Family Education: Education and the Good Life%罗素《教育与美好生活》一书所阐述的家庭教育观

    Institute of Scientific and Technical Information of China (English)

    丁毅

    2012-01-01

    罗素的《教育与美好生活》包含了大量的家庭教育思想和及早施教的教育原则,已被当今社会所认同并实施。他的“爱与同情”的教育方法对中国父母也有很大的借鉴意义。而在家庭教育的内容方面,罗素不仅重视品行教育和智力教育,更强调在家庭中施行性教育的重要性。%Bertrand Russell's Education and the Good Life contains lots of family educational thoughts. The principle of early teaching has been accepted and put into practice. The educational method of love and compassion also gives some enlightenment to Chinese parents. Besides his educational content, the book contains not only morality education and intellectual education but also sexual education.

  1. 股骨近端外侧锁定钢板治疗Russell-Taylor Ⅱ型股骨转子下骨折%Femoral subtrochanteric fractures treated with proximal lateral femur locking Plate

    Institute of Scientific and Technical Information of China (English)

    胡孙君; 陈舰; 陈杰; 俞光荣; 张世民

    2012-01-01

    目的 探讨股骨近端外侧锁定钢板治疗股骨转子下骨折的治疗效果.方法 对28例Russell-Taylor Ⅱ型股骨转子下骨折患者采用股骨近端外侧锁定钢板固定.结果 28例均获得随访,时间10~24个月.根据髋关节Harris评分:优13例,良10例,中5例.结论 股骨近端外侧锁定钢板治疗股骨转子下骨折可以达到可靠的固定效果,骨折愈合较快,短期临床疗效良好.%Objective To study the outcome of subtrochanteric hip fractures treated by proximal lateral femur locking plate. Methods 28 elder patients with subtrochanteric hip fractures were treated with proximal lateral femur locking plate. Results All patients were followed up for 10 ~24 months. According to Hams index, there were 13 excellent cases, f 0 good and 5 fair. Conclusions The proximal lateral femur locking plate is the kind of stable and effective internal fixation of treating subtrochanteric hip fractures, and the clinical outcome is satisfied.

  2. Electro-physiological and Behavioral Responses of Aleurodicus dispersus Russell to Seven Plants%螺旋粉虱对7种植物的行为及电生理反应

    Institute of Scientific and Technical Information of China (English)

    郑丽霞; 吴伟坚; 符悦冠

    2016-01-01

    为了更好地了解螺旋粉虱(Aleurodicus dispersus Russell)对寄主植物的化学选择机制,运用H型嗅觉仪和触角电位(Electroantennogram EAG)反应技术,研究了螺旋粉虱雌雄成虫对印度紫檀(Pterocarpus indicus)、番石榴(Psidium guajava)、番木瓜(Carica papaya)、香蕉(Musa supientum)、羊蹄甲(Bauhinia variegata)、大叶榄仁(Terminalia esculentum)和散尾葵(Chrysalidocarpus lutescens)等7种植物及其挥发物的嗅觉行为及电生理反应.结果表明:螺旋粉虱雌虫对印度紫檀及其挥发物表现出显著的正趋向作用;螺旋粉虱雌雄虫对散尾葵及其挥发物表现出显著的负趋向作用.在剂量反应试验中,螺旋粉虱雌虫的EAG反应随着印度紫檀挥发油和散尾葵挥发油浓度的增加而增强,当浓度增加到10 mol/L时,EAG反应最强.该研究结果可为开发螺旋粉虱田间引诱剂和驱避剂提供参考.

  3. Twin Legacies: Victor and Vincent McKusick/Twin Studies: Twinning Rates I; Twinning Rates II; MZ Twin Discordance for Russell-Silver Syndrome; Twins' Language Skills/Headlines: Babies Born to Identical Twin Couples; Identity Exchange; Death of Princess Ashraf (Twin); Yahoo CEO Delivers Identical Twins.

    Science.gov (United States)

    Segal, Nancy L

    2016-04-01

    The lives of the illustrious monozygotic (MZ) twins, Victor A. and Vincent L. McKusick, are described. Victor earned the distinction as the 'Father of Medical Genetics', while Vincent was a legendary Chief Justice of the Maine Supreme Court. This dual biographical account is followed by two timely reports of twinning rates, a study of MZ twin discordance for Russell-Silver Syndrome (RSS) and a study of twins' language skills. Twin stories in the news include babies born to identical twin couples, a case of switched identity, the death of Princess Ashraf (Twin) and a new mother of twins who is also Yahoo's CEO.

  4. On Bertrand Russell ’ s Understanding of the Debate between “Passion” and“Prudence” in the Pre-milesian Greek Society%罗素对米利都学派前古希腊社会“热情”与“审慎”的认识

    Institute of Scientific and Technical Information of China (English)

    刘加翠

    2015-01-01

    The pre-Socratic philosophy , which represents the initial attempts of the Greeks to philosophically under-stand the world of nature , refers to Greek philosophy before Socrates .The debate among ancient Greeks in that pe-riod between “passion” and“prudence” has been an important issue also of contention among numerous research-ers investigating into ancient Greek philosophy nowadays .However, in Bertrand Russell ’ s eye, with the entire Greek society back then scrutinized as a whole , the Greeks had always shown preference of “passion” over “pru-dence”.Russell even trenchantly took Greek-style serenity and solemnity as a parody of others .By delving into some hints implied in A History of Western Philosophy by Russell , who surveyed Western philosophy from the pre-Socratic philosophers to the early 20 th century , we could gain an insight into the “fanaticism” inhering in the early stages of ancient Greek civilization during the pre-Milesian period .%前苏格拉底时期是古希腊哲学的起源时期,其中,在米利都学派形成以前,希腊人是“热情”还是“审慎”的论争,也成了众多研究古希腊哲学学者一直争论不休的一个重要问题。关于这一问题,罗素认为,从当时希腊社会整体上看,希腊人则一直是“热情”多于“审慎”。罗素甚至用了一句近似尖刻的话说认为希腊人“静穆”是“拾人牙慧”。通过梳理罗素关于西方哲学发展的著名论著《西方哲学史》这一著作中的有关线索,可以从米利都学派之前希腊文明的兴起过程中窥探出希腊文明兴起源头上“狂热”的成分。

  5. Creativity Research Program and its Interactive Approach--Russell on Mutual Interaction Methodology of Science-Religion Relation%创造性研究纲领的互动路径--拉塞尔的科学与宗教方法论研究

    Institute of Scientific and Technical Information of China (English)

    刘益宇

    2014-01-01

    罗伯特·拉塞尔提出的创造性研究纲领当今科学与宗教研究领域最具建设性的创见之一。拉塞尔主要继承巴伯批判实在论类比方法的合理内核,走向互动方法;进而而发展墨菲的观点,激发科学研究纲领可以部分地根据宗教学说试验性地、假说性地产生的洞见;突破皮考克的突现认知整体主义中宗教位于层级体系顶部的局限。拉塞尔提出这种富有建设性的新型方法论,强调从科学和宗教两方面出发,走向两者的动态而又对称的互动,具有很强的现实应用性,为科学与宗教的现实互动提供了有效的指导纲领,并带来了新型的转变。%The methodology of“creative mutual interaction”(CMI), proposed by Russell, can be regarded as one of most constructive perspective in the contemporary science-religion academia. Russell mainly inherited reasonable connotations of Barbour’s analogical methodology, and then turned into an interactive methodology;then extended Murphy’s agenda to use Lakatosian methodology to inspire scientific research programs based in part on insights from theological doctrines;surmounted the constraints of Peacock’s epistemic holism of emergence. Finally, Russell stated this new kind of constructive methodology. This new one emphasizes that we should move both ways between theology and science instead of generating research just within religion in light of science. What this new transformation offers is a new direction for science-theology relation---to build a new dynamic, though asymmetric, interaction.

  6. Liquid Crystal Alignment With a PhotoCrosslin kable and Solvent-Soluble Polyimide Film%用可光聚合和可溶的聚酰亚胺薄膜作液晶取向层

    Institute of Scientific and Technical Information of China (English)

    李文清; 徐成书; 吴思聪

    2000-01-01

    我们开发了一种含苯乙烯侧链的可光聚合和可溶的新型聚酰亚胺(PICA),用于对向列相液晶取向.用长波线性偏振紫外光(LPUV)照射PICA薄膜,能得到很好的液晶取向.液晶的取向方向垂直于入射LPUV光的偏振轴.由PICA薄膜诱发的液晶分子的取向,在加热至85℃并保持450小时后仍保持不变.采用两次曝光的方法能使PICA薄膜产生小的预倾角.

  7. Water quality of heather industry in Lorca (Spain); Depuracion de aguas del sector de curtidos en Lorca

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The company Aquagest Levante, S. A. is building a new wastewater treatment plant to solve the environmental problems in the Gaudalentin River. This plant is going to treat the water for all the leather industries in the village of Lorca (Murcia), grouped in the association SARCUSA. This project has some innovative technologies to profit the natural resources, as a tertiary treatment based on nano filtration and evaporation, to recycle the water in agriculture and industry or a thermal sludge drying at low temperature-STC system-to minimize the residue and reuse for agriculture application, associated to a cogeneration to optimize the energetic costs for all the treatment system. (Author)

  8. “Weary for the Heather and the Deer”: R. L. Stevenson Depicts the Scottish Diasporic Experience

    Directory of Open Access Journals (Sweden)

    Christy Danelle Di Frances

    2015-07-01

    Full Text Available Robert Louis Stevenson is well known as a writer of popular Victorian adventures, yet much of his fiction is steeped in the cultural and historical preoccupations of Scotland. Texts such as Kidnapped (1886, The Master of Ballantrae (1889, and Catriona (1893 hinge upon culturally significant events such as the Jacobite Rising of 1745 and the Appin Murder. These works also allude to the Highland Clearances of the eighteenth and nineteenth centuries and the Battle of Culloden with its ensuing disarming acts—all occurrences which contributed to or comprised significant catalysts for the large-scale expulsion of Scots from their homeland. Certainly, themes of exile pervade Stevenson’s Scottish work and maintain a more liminal presence in his later South Seas fiction, and many of the author’s finest characters can be read as enactments of temporary or permanent expatriates whose real-life counterparts form a fascinating cross-section of the diasporic movement. This paper focuses on several of these characters, whose adventures are encoded into their corresponding texts as fictional re-constructions of a broader experience common to displaced Scots in the eighteenth and nineteenth centuries. Some are driven from Scotland as a direct result of economic hardship or domestic conflict, while others leave (at least temporarily as a means of avoiding the political corruption and intrigue characteristic of the historical struggle for Scottish independence. Through characters like David Balfour, Alan Breck Stewart, James Durie, and Archie Weir, Stevenson explores the psychological ramifications of politically enforced and self-imposed exile, thus providing fictional extrapolations of the Scottish diasporic experience. These portrayals, infused with a the author’s own experiences abroad, offer fascinating microcosms which gesture towards the collective experience of a wide-scale network of displaced Scots in the Victorian world. An early version of this paper was presented at the NAVSA 2012 “Victorian Networks” conference hosted by the University of Wisconsin at Madison.

  9. 75 FR 51045 - Pesticide Products; Registration Applications

    Science.gov (United States)

    2010-08-18

    ... 18300, Greensboro, NC 27419. Active ingredient: Trinexapac ethyl. Proposed use: Grass grown for seed... ingredient: Clothianidin. Proposed use: Mustard seed. Contact: Kable Bo Davis, (703) 306-0415, davis.kable..., guava, mango, olive, pomegranate, pome fruit, and stone fruit; conifers, eucalyptus; and...

  10. Summary of the Richard B. Russell Concrete Dam Vibration Study.

    Science.gov (United States)

    1988-02-01

    REPORT (Year. Month,. Day) 15 PAGE COUN T - ., tROM _____To __ Februarv 1988 6 5K51EN’S" 0-A-ON Aabsle f--m National Technical Information Service, 5285...SL, and was edited by Ms. Lee T. Byrne of the Information Products Division, Information Technology Laboratory, WES. COL Dwayne G. Lee, CE, is the...the dam. 50. Measurements from both tests at the relative joint motion arrays indicated relative motions between monoliths. The nonlinear behavoir of

  11. Russell Lecture Dark Star Formation and Cooling Instability

    CERN Document Server

    Lynden-Bell, Donald

    2001-01-01

    Optically thin cooling gas at most temperatures above 30K will make condensations by pressure pushing material into cool dense regions. This works without gravity. Cooling condensations will flatten and become planar/similarity solutions. Most star formation may start from cooling condensations - with gravity only important in the later stages. The idea that some of the dark matter could be pristine white dwarfs that condensed slowly on to planetary sized seeds without firing nuclear reactions is found lacking. However, recent observations indicate fifty times more halo white dwarfs than have been previously acknowledged; enough to make the halo fraction observed as MACHOS. A cosmological census shows that only 1% of the mass of the Universe is of known constitution.

  12. Historical Investigations of the Richard B. Russell Multiple Resource Area.

    Science.gov (United States)

    1981-11-01

    Howard W. Southern Regions of the United States. Chapel Hill, North Carolina: University of North Carolina Press, 1936. 443 Oliphant, J. Orin . [ed...South Carolina, 1978. 515 Thompson, Edgar T. [ed.]. Perspectives on the South: Agenda for Research. Durham, North Carolina: Duke University Press...1967. 516 Thompson, Edgar T. Plantation Societies, Race Relations and The South: The Regimentation of Population Durham, North Carolina: Duke University

  13. Cool Stars in the Hertzsprung-Russell Diagram

    CERN Document Server

    van Loon, Jacco Th

    2015-01-01

    As the opening review to the focus meeting ``Stellar Behemoths: Red Supergiants across the Local Universe'', I here provide a brief introduction to red supergiants, setting the stage for subsequent contributions. I highlight some recent activity in the field, and identify areas of progress, areas where progress is needed, and how such progress might be achieved.

  14. 76 FR 23342 - Russell Investment Management Company, et al.;

    Science.gov (United States)

    2011-04-26

    ... adopted or will adopt a Code of Ethics as required under rule 17j- 1 under the Act, which contains... as an ``ETF,'' an ``investment company,'' a ``fund,'' or a ``trust.'' All marketing materials...

  15. An approach to the natural: the Kenneth Russell memorial lecture.

    Science.gov (United States)

    Beasley, Wyn

    2007-12-01

    This paper reports on the disability resulting from the dislocation, later recurrent, of the right shoulder suffered by Winston Churchill in 1896. It considers the management principles enunciated by Hippocrates and their relevance to his situation and to contemporary practice.

  16. Outburst flood evolution at Russell Glacier, western Greenland

    DEFF Research Database (Denmark)

    Carrivick, Jonathan; Russell, Andrew; Ingeman-Nielsen, Thomas;

    2013-01-01

    Outburst floods have produced a distinctive and widespread Quaternary record both onshore and offshore via widespread and intense geomorphological impacts, yet these impacts remain poorly understood due to a lack of modern analogues. This study therefore makes the first systematic quantification ...

  17. The Road Inventory of Charles M Russell Wetlands Management District

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — To determine the relative needs of the U.S. Fish and Wildlife Service, the Federal Highway Administration (FHWA) was asked to inventory all public access and...

  18. The Road Inventory of Charles M Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — To determine the relative needs of the U.S. Fish and Wildlife Service, the Federal Highway Administration (FHWA) was asked to inventory all public access and...

  19. Magnetic AP Stars in the Hertzsprung-Russell Diagram

    Science.gov (United States)

    Hubrig, S.; North, P.; Mathys, G.

    2000-08-01

    The evolutionary state of magnetic Ap stars is rediscussed using the recently released Hipparcos data. The distribution of the magnetic Ap stars of mass below 3 Msolar in the H-R diagram differs from that of the normal stars in the same temperature range at a high level of significance. Magnetic stars are concentrated toward the center of the main-sequence band. This is shown in two forms of the H-R diagram: one where logL is plotted against logTeff and a version more directly tied to the observed quantities, showing the astrometry-based luminosity (Arenou & Luri) against the (B2-G)0 index of Geneva photometry. In particular, it is found that magnetic fields appear only in stars that have already completed at least approximately 30% of their main-sequence lifetime. No clear picture emerges as to the possible evolution of the magnetic field across the main sequence. Hints of some (loose) relations between magnetic field strength and other stellar parameters are found: stars with shorter periods tend to have stronger fields, as do higher temperature and higher mass stars. A marginal trend of the magnetic flux to be lower in more slowly rotating stars may possibly be seen as suggesting a dynamo origin for the field. No correlation between the rotation period and the fraction of the main-sequence lifetime completed is observed, indicating that the slow rotation in these stars must already have been achieved before they became observably magnetic. Based on data from the ESA Hipparcos satellite and on observations collected at the European Southern Observatory (La Silla, Chile; ESO programs Nos. 43.7-004, 44.7-012, 49.7-030, 50.7-067, 51.7-041, 52.7-063, 53.7-028, 54.E-0416, and 55.E-0751), at the Observatoire de Haute-Provence (Saint-Michel l'Observatoire, France), at Kitt Peak National Observatory, and at the Canada-France-Hawaii Telescope.

  20. Outburst flood evolution at Russell Glacier, western Greenland

    DEFF Research Database (Denmark)

    Carrivick, Jonathan L.; Turner, Andy G.D.; Russell, Andrew J.

    2013-01-01

    Glacial lake outburst floods have produced a distinctive and widespread Quaternary record both onshore and offshore via widespread and intense geomorphological impacts, yet these impacts remain poorly understood due to a lack of modern analogues. This study therefore makes a systematic quantifica......Glacial lake outburst floods have produced a distinctive and widespread Quaternary record both onshore and offshore via widespread and intense geomorphological impacts, yet these impacts remain poorly understood due to a lack of modern analogues. This study therefore makes a systematic...... quantification of the evolution of a bedrock-channelled outburst flood. Channel topography was obtained from digitised aerial photographs, a 5 m grid resolution DEM and bathymetric surveys. Flood inundation was measured in the field from dGPS measurements. Flood evolution was analysed with application...... of a numerical model. Novel flood metrics, including ‘rate-of-rise-to-peak’ and ‘persistence-above-a-value’ of hydraulics were calculated. The key findings were that outburst floods; (i) that enter intermediary lakes are dramatically attenuated in terms of propagation whilst basin filling proceeds to the outlet...

  1. Water Quality Studies: Richard B. Russell and Clarks Hill Lakes.

    Science.gov (United States)

    1986-12-01

    oxygenation of a major portion of the hypo- limnion of the lower portion of the main basin during the stratified period. 66. Dissolved oxygen depletion was...major portion of the hypo- limnion at Station 130, 140, and 150 on 25 March, 1985. These patterns were suggestive of influences from inflows to these...November. This pattern was evident from data collected on 1, 4, and 6 November (Figure 47). Stratified conditions and isolation of the hypo- limnion

  2. Using Health Data - Applying Technology to Work Smarter Grain Heather Proctor Paula Using Health Data - Applying Technology to Work Smarter 276 + CD Elsevier 9780729538893 0729538893 [Formula: see text].

    Science.gov (United States)

    2010-05-26

    The title gives the impression that this book will be about the collection and analysis of healthcare data, but its actual focus is how to use the Microsoft Office 2007 suite of programs in the healthcare setting.

  3. Using health data: applying technology to work smarter Heather Grain Using health data: applying technology to work smarter Paula Procter Elsevier £20.99 276pp 9780729538893 0729538893 [Formula: see text].

    Science.gov (United States)

    2010-09-02

    The TITLE of this book may give the impression that it concerns the collection and analysis of healthcare data, but it is actually about how to use Microsoft office 2007 software in healthcare settings.

  4. Using health data: applying technology to work smarter Heather Grain Paula Procter Elsevier Using health data: applying technology to work smarter £20.99 276pp 9780729538893 0729538893 [Formula: see text].

    Science.gov (United States)

    2010-10-07

    THE TITLE of this book may give the impression that it concerns the collection and analysis of healthcare data, but it is actually about how to use Microsoft office 2007 software in healthcare settings.

  5. 2015 Russell Ross Memorial Lecture in Vascular Biology: Protective Autoimmunity in Atherosclerosis.

    Science.gov (United States)

    Ley, Klaus

    2016-03-01

    Atherosclerosis is an inflammatory disease of the arterial wall. It is accompanied by an autoimmune response against apolipoprotein B-100, the core protein of low-density lipoprotein, which manifests as CD4 T cell and antibody responses. To assess the role of the autoimmune response in atherosclerosis, the nature of the CD4 T cell response against apolipoprotein B-100 was studied with and without vaccination with major histocompatibility complex-II-restricted apolipoprotein B-100 peptides. The immunologic basis of autoimmunity in atherosclerosis is discussed in the framework of theories of adaptive immunity. Older vaccination approaches are also discussed. Vaccinating Apoe(-/-) mice with major histocompatibility complex-II-restricted apolipoprotein B-100 peptides reduces atheroma burden in the aorta by ≈40%. The protective mechanism likely includes secretion of interleukin-10. Protective autoimmunity limits atherosclerosis in mice and suggests potential for developing preventative and therapeutic vaccines for humans.

  6. 78 FR 30941 - Frank Russell Company, et al.; Notice of Application

    Science.gov (United States)

    2013-05-23

    ... where the fees are disclosed to other prospective and existing customers. Applicants submit that the... than quarterly, with information about the profitability of such Adviser on a per-Fund basis. The information will reflect the impact on profitability of the hiring or termination of any money manager...

  7. [Silver-Russell syndrome (hemihypertrophy) and cor triatriatum in a newborn].

    Science.gov (United States)

    Ríos-Méndez, Raúl Enrique; Montero-Monar, Hernán Eduardo; Pernández-Alvarado, Antonio Pedro; Hidalgo-Flores, Einstein Gustavo

    2015-06-01

    Hemihypertrophy syndrome and cor triatriatum are extremely rare pathologies. Hemihypertrophy is defined as complete or partial overgrowth of one of the hemibodies. Cor triatriatum is a congenital heart disease characterized by a membrane which separates the left atrium into two chambers; if that membrane has a restrictive hole, it causes obstruction to blood passage from the pulmonary veins into the left ventricle causing hypertension and pulmonary edema. In this context, the patent ductus arteriosus can act as a means of decompression of the pulmonary circuit, because it allows the blood passage from the pulmonary artery to the aorta. We report a patient with Silver-Rusell syndrome (hemihypertrophy), cor triatriatum and ductus arteriosus with reverse flow. To our knowledge, this association of rare pathologies and this clinical presentation have not been described previously.

  8. Preliminary selenium assessment of the Charles M. Russell Wetland Management District

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — During the summer of 2012, the Montana Ecological Services Environmental Contaminants Program measured various field water quality parameters and collected surface...

  9. Retrenchment: General Russell E. Dougherty and the Strategic Air Command During the Age of Detente

    Science.gov (United States)

    2014-06-01

    what happened to Ruth Farnsworth, or the scrutiny of a death penalty case brewing with the undercurrents of racial tension, Dougherty grew...to do what there was to do. Guam was on a beer -and-taxicab economy.”30 Gerry became sick as well. She was forced to have surgery for a growth on

  10. A new cycle of jökulhlaups at Russell Glacier, Kangerlussuaq, West Greenland

    DEFF Research Database (Denmark)

    Russell, Andrew J.; Carrivick, Jonathan L.; Ingeman-Nielsen, Thomas;

    2011-01-01

    years. Robust calculations of lake volumes and peak discharges are made, based onintensive field surveys and utilizing high-spatial-resolution orthophotographs of the lake basin and icemargin. These data enable identification of controls on the behaviour of the ice-dammed lake andprovide the first field...

  11. Optic neuritis caused by canine distemper virus in a Jack Russell terrier.

    Science.gov (United States)

    Richards, Tara R; Whelan, Nick C; Pinard, Chantale L; Alcala, Fernanda Castillo; Wolfe, Katheryn C

    2011-04-01

    An atypical case of canine distemper (CD) was diagnosed in a vaccinated healthy adult dog. The patient was presented circling, seizuring, and blind. Postmortem examination resulted in a diagnosis of CD. Optic neuritis was diagnosed, a finding not previously described in the context of CD virus infection presenting solely with neurological signs.

  12. Preliminary studies of the CHIM electrogeochemical method at the Kokomo Mine, Russell Gulch, Colorado

    Science.gov (United States)

    Smith, D.B.; Hoover, D.B.; Sanzolone, R.F.

    1993-01-01

    The CHIM electrogeochemical exploration technique was developed in the former Soviet Union about 20 years ago and is claimed to be effective in exploration for concealed mineral deposits that are not detectable by other geochemical or geophysical techniques. The method involves providing a high-voltage direct current to an anode and an array of special collector cathodes. Cations mobile in the electric field are collected at the cathodes and their concentrations determined. The U.S. Geological Survey started a study of the CHIM method by conducting tests over a precious- and base-metal-bearing quartz vein covered with 3 m of colluvial soil and weathered bedrock near the Kokomo Mine, Colorado. The tests show that the CHIM method gives better definition of the vein than conventional soil geochemistry based on a total-dissolution technique. The CHIM technique gives reproducible geochemical anomaly patterns, but the absolute concentrations depend on local site variability as well as temporal variations. Weak partial dissolutions of soils at the Kokomo Mine by an enzyme leach, a dilute acetic acid leach, and a dilute hydrochloric acid leach show results comparable to those from the CHIM method. This supports the idea that the CHIM technique is essentially a weak in-situ partial extraction involving only ions able to move in a weak electric field. ?? 1993.

  13. PROBLEM INSIDER DAN OUTSIDER DALAM STUDI AGAMA Telaah atas Pemikiran Russel T. McCutcheon

    Directory of Open Access Journals (Sweden)

    Mudrik al-farizi

    2012-09-01

    Full Text Available Islam ditinjau dari sudut waktunya berproses pada dua rentang waktu yang berbeda tetapi tidak dapat dipisahkan, yaitu pada masa proses tashri> (masa Nabi dan pasca proses tashri>’ (sejak masa sahabat sampai sekarang. Rentang waktu yang sangat panjang dalam historiografi tashri>’ tersebut sudah tentu menimbulkan beragam permasalahan multi dimensi yang berbeda bagi Islam dalam kapasitasnya sebagai problem solver dalam kehidupan manusia. Oleh karena itu, studi Islam—oleh sebagian orang—dianggap tidak cukup hanya dilakukan dengan analisis teks (textual analysis belaka, melainkan harus dikaitkan dengan konteks yang melatarinya, baik pada saat teks (baca: nas}s} diturunkan, maupun konteks yang melatari saat teks akan diterapkan dalam dimensi ruang dan waktu yang berbeda. Problem epistemologis studi Islam pada mulanya bertumpu pada idealisme dengan menjadikan teks-teks suci sebagai satu-satunya sumber kebenaran, pada perkembangannya bergerak menuju empirisme dengan memandang bahwa Islam tidak bisa dilihat hanya dari teks-teks sucinya, karena Islam telah menjadi budaya dalam perilaku penganutnya. Karena itu studi Islam pada masa modern berkembang dalam berbagai model pendekatan ilmu pengetahuan, seperti antropologi, sosiologi, sejarah, dan lainnya. Salah satu bentuk perkembangan pendekatan dalam memahami Islam ialah adanya pemilahan perspektif antara insider (pemeluk agama yang dikaji dengan outsider (orang luar yang bukan pemeluk agama yang menjadi obyek kajian.

  14. Energetic properties of stellar pulsations across the Hertzsprung-Russell diagram

    Science.gov (United States)

    Daszyńska-Daszkiewicz, Jadwiga

    2015-09-01

    I will review types of modes which are observed in stars with different masses and on various evolutionary stages. In particular, I will focus on energetic aspects of oscillation modes, i.e., excitation, distribution of kinetic energy, mode amplitude and lifetime.

  15. Situk River Hydrology Following Closure of Russell Fiord by Hubbard Glacier

    Science.gov (United States)

    2011-03-01

    heights from GPS (using their geoid models) and their own NAVD88 heights. However, the disagreement on NGS data- sheets for Yakutat is around 1.5 m...This is because the geoid or the mod- eled NAVD88 surface simply isn’t well known in the vicinity of Yakutat, primarily because of isostatic rebound

  16. Leibniz's Infinitesimals: Their Fictionality, Their Modern Implementations, And Their Foes From Berkeley To Russell And Beyond

    CERN Document Server

    Katz, Mikhail G; 10.1007/s10670-012-9370-y

    2012-01-01

    Many historians of the calculus deny significant continuity between infinitesimal calculus of the 17th century and 20th century developments such as Robinson's theory. Robinson's hyperreals, while providing a consistent theory of infinitesimals, require the resources of modern logic; thus many commentators are comfortable denying a historical continuity. A notable exception is Robinson himself, whose identification with the Leibnizian tradition inspired Lakatos, Laugwitz, and others to consider the history of the infinitesimal in a more favorable light. Inspite of his Leibnizian sympathies, Robinson regards Berkeley's criticisms of the infinitesimal calculus as aptly demonstrating the inconsistency of reasoning with historical infinitesimal magnitudes. We argue that Robinson, among others, overestimates the force of Berkeley's criticisms, by underestimating the mathematical and philosophical resources available to Leibniz. Leibniz's infinitesimals are fictions, not logical fictions, as Ishiguro proposed, but ...

  17. Deciphering the evolution of birdwing butterflies 150 years after Alfred Russel Wallace

    Science.gov (United States)

    Condamine, Fabien L.; Toussaint, Emmanuel F. A.; Clamens, Anne-Laure; Genson, Gwenaelle; Sperling, Felix A. H.; Kergoat, Gael J.

    2015-01-01

    One hundred and fifty years after Alfred Wallace studied the geographical variation and species diversity of butterflies in the Indomalayan-Australasian Archipelago, the processes responsible for their biogeographical pattern remain equivocal. We analysed the macroevolutionary mechanisms accounting for the temporal and geographical diversification of the charismatic birdwing butterflies (Papilionidae), a major focus of Wallace’s pioneering work. Bayesian phylogenetics and dating analyses of the birdwings were conducted using mitochondrial and nuclear genes. The combination of maximum likelihood analyses to estimate biogeographical history and diversification rates reveals that diversity-dependence processes drove the radiation of birdwings, and that speciation was often associated with founder-events colonizing new islands, especially in Wallacea. Palaeo-environment diversification models also suggest that high extinction rates occurred during periods of elevated sea level and global warming. We demonstrated a pattern of spatio-temporal habitat dynamics that continuously created or erased habitats suitable for birdwing biodiversity. Since birdwings were extinction-prone during the Miocene (warmer temperatures and elevated sea levels), the cooling period after the mid-Miocene climatic optimum fostered birdwing diversification due to the release of extinction. This also suggests that current global changes may represent a serious conservation threat to this flagship group. PMID:26133078

  18. Energetic properties of stellar pulsations across the Hertzsprung-Russell diagram

    Directory of Open Access Journals (Sweden)

    Daszyńska-Daszkiewicz Jadwiga

    2015-01-01

    Full Text Available I will review types of modes which are observed in stars with different masses and on various evolutionary stages. In particular, I will focus on energetic aspects of oscillation modes, i.e., excitation, distribution of kinetic energy, mode amplitude and lifetime.

  19. Charles M. Russell and UL Bend National Wildlife Refuge: A Report on Wilderness Character Monitoring

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is the completed effort of the U.S. Fish and Wildlife Service, Wilderness Fellows program to develop a monitoring strategy and evaluate the status of...

  20. Enemigos naturales de la mosca blanca Aleurodicus dispersus Russell (Homoptera: Aleyrodidae): parasitoides y depredadores.

    OpenAIRE

    2016-01-01

    Se estudió la composición de parasitoides y depredadores de la mosca blanca en espiral Aleurodicus dispersus así como la abundancia relativa de las primeras diez fincas productoras de banano, durante 1997 y 1998 en Matina, Limón, Costa Rica. Se recuperaron cuatro especies de parasitoides de ninfas de mosca blanca Encarsiella noyesi Hayat, E. aleurodici (Girault), Encarsiella probo nsp. y Encarsia guadeloupae Viggiani. Los depredadores de ninfas y adultos de mosca blanca más comunes fueron dos...

  1. Silver-Russell Syndrome & Small for Gestational Age : Long-term health perspectives

    NARCIS (Netherlands)

    C.C.J. Smeets (Lin)

    2017-01-01

    markdownabstractFor over 25 years, our research group and others have been investigating children born small for gestational age (SGA) with persistent short stature, and the efficacy and safety of biosynthetic growth hormone treatment (GH) in these children. One of the causes of short SGA is

  2. The sperm ultrastructure of Caurinus dectes Russell (Mecoptera: Boreidae) and its phylogenetic implications.

    Science.gov (United States)

    Russell, Loren K; Dallai, Romano; Gottardo, Marco; Beutel, Rolf G

    2013-12-01

    The sperm structure of the enigmatic mecopteran species Caurinus dectes (Boreidae) is described for the first time. Diagnostic features are the bi-layered acrosome, a cylindric nucleus provided with two longitudinal opposite grooves, and a simple 9 + 2 axoneme which degenerates in the posterior tail end. The results are conform with the monophyly of Mecoptera including Boreidae. A possible autapomorphy of the order is the presence of the two longitudinal opposite grooves along the nucleus, and the presence of two electron-dense fibres beneath the axoneme. Some apparently plesiomorphic features are preserved in the sperm of Caurinus. Features characterizing the distal part of the flagellum, including the presence of an axial cylindrical structure and the distinctive type of axoneme degeneration, are potential synapomorphies of Caurinus and Boreus, i.e. autapomorphic traits of Boreidae. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Getting into a Russell Group University: High Scores and Private Schooling

    Science.gov (United States)

    Hemsley-Brown, Jane

    2015-01-01

    Despite substantial prior research on higher education choice, top universities in the UK continue to stand accused of favouring socio-economically advantaged students, to the detriment of those from poorer backgrounds. The objectives of this study are to test whether students with the same or equivalent entry scores are more or less likely to…

  4. Wittgenstein on Circularity in the Frege-Russell Definition of Cardinal Number

    NARCIS (Netherlands)

    de Bruin, B.P.

    2008-01-01

    Several scholars have argued that Wittgenstein held the view that the notion of number is presupposed by the notion of one-one correlation, and that therefore Hume's principle is not a sound basis for a definition of number. I offer a new interpretation of the relevant fragments from Wittgenstein's

  5. Definition of the Pleiades Main Sequence in the Hertzsprung-Russell Diagram

    Science.gov (United States)

    Hansen-Ruiz, C. S.; van Leeuwen, F.

    1997-08-01

    The Pleiades main sequence is intrinsically of very small width. Disturbances to this width come primarily from three sources: local interstellar reddening (related to the reflection nebulae), multiplicity and variations in the distance moduli related to the size of the cluster (~20 pc diameter). Walraven 5-channel photometry can be used to remove most of the reddening related effects. A full literature survey was made concerning multiplicity to provide information needed to correct for multiplicity effects. The locus of the resulting corrected main sequence can be determined using Hipparcos parallaxes (van Leeuwen and Hansen-Ruiz 1997), providing a well defined observational isochrone for the study of stellar evolution and stellar structure. Preliminary results are presented.

  6. The complete mitochondrial genome of a spiraling whitefly, Aleurodicus dispersus Russell (Hemiptera: Aleyrodidae).

    Science.gov (United States)

    Ming-Xing, Lu; Zhi-Teng, Chen; Wei-Wei, Yu; Yu-Zhou, Du

    2017-03-01

    We report the complete mitochondrial genome (mitogenome) of a spiraling whitefly, Aleurodicus dispersus (Hemiptera: Aleyrodidae). The 16 170 bp long genome consists of 13 protein-coding genes, 20 transfer RNAs, 2 ribosomal RNAs, and a control region. The A. dispersus mitogenome also includes a cytb-like non-coding region and shows several variations relative to the typical insect mitogenome. A phylogenetic tree has been constructed using the 13 protein-coding genes of 12 related species from Hemiptera. Our results would contribute to further study of phylogeny in Aleyrodidae and Hemiptera.

  7. Deciphering the evolution of birdwing butterflies 150 years after Alfred Russel Wallace.

    Science.gov (United States)

    Condamine, Fabien L; Toussaint, Emmanuel F A; Clamens, Anne-Laure; Genson, Gwenaelle; Sperling, Felix A H; Kergoat, Gael J

    2015-07-02

    One hundred and fifty years after Alfred Wallace studied the geographical variation and species diversity of butterflies in the Indomalayan-Australasian Archipelago, the processes responsible for their biogeographical pattern remain equivocal. We analysed the macroevolutionary mechanisms accounting for the temporal and geographical diversification of the charismatic birdwing butterflies (Papilionidae), a major focus of Wallace's pioneering work. Bayesian phylogenetics and dating analyses of the birdwings were conducted using mitochondrial and nuclear genes. The combination of maximum likelihood analyses to estimate biogeographical history and diversification rates reveals that diversity-dependence processes drove the radiation of birdwings, and that speciation was often associated with founder-events colonizing new islands, especially in Wallacea. Palaeo-environment diversification models also suggest that high extinction rates occurred during periods of elevated sea level and global warming. We demonstrated a pattern of spatio-temporal habitat dynamics that continuously created or erased habitats suitable for birdwing biodiversity. Since birdwings were extinction-prone during the Miocene (warmer temperatures and elevated sea levels), the cooling period after the mid-Miocene climatic optimum fostered birdwing diversification due to the release of extinction. This also suggests that current global changes may represent a serious conservation threat to this flagship group.

  8. "A Prison for the Infinite": D. H. Lawrence and Bertrand Russell on the War

    OpenAIRE

    Ferretter, Luke

    2015-01-01

    In his recent book War Trauma and English Modernism, Carl Krockel argues that Lawrence suffered from "war trauma," throughout not only the war years but for almost the entire remainder of his life. He is right to say so. The war smashed Lawrence, as an artist and as a man, and I would disagree with Krockel's thesis only insofar as he sees the beginning of a healing process at work in the final draft of Lady Chatterley's Lover (153-4). Lawrence responded to the war in many ways at the time – t...

  9. Analysis of impairment : Charles M. Russell National Wildlife Refuge Enhancement Act of 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This analysis of impairment is regarding the proposal to create private ownership of 12 federally-leased cabin sites in the South Fork of Rock Creek as per the...

  10. 77 FR 26781 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT

    Science.gov (United States)

    2012-05-07

    ..., and environmental education and interpretation. We will review and update the CCP at least every 15... to this and early in the preplanning phase, we outlined a process that would be inclusive of diverse... opportunities for young hunters. We would manage Refuge access to benefit public and economic uses. Access...

  11. Composteren van materialen die vrijkomen bij het beheer van heidevelden : Composting of materials resulting from heathland management

    NARCIS (Netherlands)

    Riem Vis, F.

    1985-01-01

    As heather materials contain relatively little easily decomposable organic matter, the composting process proceeds slowly. Composted heather materials have low contents of nutrients , a low electrical conductivity and a rather low pH

  12. Composteren van materialen die vrijkomen bij het beheer van heidevelden : Composting of materials resulting from heathland management

    NARCIS (Netherlands)

    Riem Vis, F.

    1985-01-01

    As heather materials contain relatively little easily decomposable organic matter, the composting process proceeds slowly. Composted heather materials have low contents of nutrients , a low electrical conductivity and a rather low pH

  13. Americans Want to Be Fit, but Most Don't Put in The Effort

    Science.gov (United States)

    ... activity recommendations, said Heather Hausenblas, a professor of kinesiology at Jacksonville University in Florida. In fact, only ... a problem." SOURCES: Heather Hausenblas, Ph.D., professor, kinesiology, Jacksonville University, Jacksonville, Fla.; Pamela Peeke, M.D., ...

  14. Offshore aerosorgailuentzako plataforma flotatzaileen eredu dinamiko sinplifikatua

    OpenAIRE

    2015-01-01

    Lan honetan, offshore aerosorgailuentzako eredu dinamiko sinplifikatuak programatu dira Matlab bidez, horretarako lehendabizi beste mekanismo batzuen modelo dinamikoak diseinatuz, proiektuaren helburua den plataformaren eredua programatzeko beharrezko ezagutzak eskuratzeko. Simulatu nahi den plataforma mota, “Tension Leg Platform” deituriko itsasoko lurzoruari kable edo sirga batzuen bidez lotzen den plataforma flotatzailea da, zeinak kableen luzeraren kontrolarekin plataformaren egonkorta...

  15. 77 FR 45629 - Animal Generic Drug User Fee Rates and Payment Procedures for Fiscal Year 2013

    Science.gov (United States)

    2012-08-01

    ... FDA's Center for Veterinary Medicine. FDA records the official abbreviated application receipt date as...AGDUFA/default.htm or contact Lisa Kable, Center for Veterinary Medicine (HFV- 10), Food and Drug... the Center for Veterinary Medicine (CVM) at: cvmagdufa@fda.hhs.gov . SUPPLEMENTARY INFORMATION:...

  16. [Montana MOYOCO Invasive Species Strike Team Final Report 2013] Charles M. Russel National Wildlife Refuge, Benton Lake ISST

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The MOYOCO (MT) Invasive Species Strike Team is made up of two field strike teams, housed at Benton Lake and Lee Metcalf National Wildlife Refuges, yet administered...

  17. [Montana MOYOCO Invasive Species Strike Team Final Report 2014] Charles M. Russel National Wildlife Refuge, Benton Lake ISST

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The MOYOCO (MT) Invasive Species Strike Team is made up of two field strike teams, housed at Benton Lake and Lee Metcalf National Wildlife Refuges, yet administered...

  18. Insights about children for parents from eminent writers: from Dante and Castiglione to Mark Twain and Bertrand Russell.

    Science.gov (United States)

    Carey, William B

    2006-02-01

    Behavioral science and literature have had a long and complex relationship with each other, sometimes differing and sometimes similar in ways of portraying human development. In the ancient world nature seems to have been the dominant explanation of human variations in both science and literature. That speculative philosophical view persisted into the late Middle Ages and the Renaissance among the academicians, while the best literature moved ahead by introducing the modern view of an interaction between nature and nurture. In the modern era literature began to describe the inner world of children a century before the birth of child psychology, and literature has generally continued to describe the interactions between nature and nurture without taking sides in the academic battles of science. The great wealth of insights into the origins of children's behavior in the nonscientific literature should be incorporated into the education of child health professionals because the richer understanding that it engenders would lead to better child rearing and educational practice.

  19. Paintings from the Cushing/Whitney Library of Yale University: the Eleventh Kenneth Fitzpatrick Russell Memorial Lecture - 2012.

    Science.gov (United States)

    Low, Gordon

    2013-12-01

    In the early years of the introduction of Christianity into China, one American medical missionary distinguished himself by his kindness and generosity towards the Chinese people, and also by his surgical prowess. Peter Parker (1804-1888) was a graduate from the Yale University Medical School and was also an ordained minister. He came to the south China city of Canton (now called Guangzhou) in 1834, built a hospital, treated the patients without charge and also groomed medical apprentices to help him in his work. He so impressed a Chinese artist, Lam Qua (1801-1860) that Lam offered to paint in oil, without charge, some of the unusual patients of Parker. Parker stayed in China until 1857. Altogether, there are about 109 paintings. More than 80 of them are in the Harvey Cushing/John Hay Whitney Medical Historical Library of the Yale University Medical School, New Haven, and 23 of them are in Guy's Hospital, London. A description of some of the paintings, together with accounts of Parker and Lam are discussed. © 2013 Royal Australasian College of Surgeons.

  20. Positioning University as a Brand: Distinctions between the Brand Promise of Russell Group, 1994 Group, University Alliance, and Million+ Universities

    Science.gov (United States)

    Furey, Sheila; Springer, Paul; Parsons, Christine

    2014-01-01

    Branding is now widely used by higher education (HE) institutions, yet questions still surround the transference of private sector concepts to a university context. This article reports on findings from studies that investigated the brand promises of four UK universities--one from each of the HE "mission groups." The evidence indicated…

  1. Modesty and Humility with Charles Robert Darwin and Alfred Russel Wallace%达尔文-华莱士之让

    Institute of Scientific and Technical Information of China (English)

    方舟子

    2009-01-01

    1831年12月27日,刚刚从剑桥大学神学院毕业的达尔文作为一名无报酬的博物学家,随贝格尔号扬帆起航,开始了历时5年的环球考察。此时他还是一个正统的基督教徒。贝格尔号绕地球一圈,于1836年10月2日回到英国的时候,

  2. Anti-venom potential of aqueous extract of stem bark of Mangifera indica L. against Daboia russellii (Russell's viper) venom.

    Science.gov (United States)

    Dhananjaya, B L; Zameer, F; Girish, K S; D'Souza, Cletus J M

    2011-06-01

    Several plant extracts rich in pharmacologically active compounds have shown to antagonize venom of several species. Mangifera indica has been used against snakebite by the traditional healers. However, there is paucity of scientific data in support. In this study, we evaluated the antivenom potential of aqueous extract of stem bark of M. indica against D. russellii venom-induced pharmacological effects such as life myotoxicity, edema, LD50 etc. The extract inhibited the phospholipase, protease, hyaluronidase, 5'nucleotidase, ATPase and alkaline phosphomonoesterase activities with varying IC50 values. It significantly inhibited both metalloproteases and serine proteases activities. Further, the extract significantly reduced the myotoxicity of the venom, as evident by the reduction of serum creatin kinase and lactate dehydrogenase activities. Though the extract completely inhibited in vitro PLA2 activity, it was unable to completely inhibit in situ hemolytic and in vivo edema-inducing activities, usually brought about by PLA2s. In lethality studies, co-injection of the venom preincubated with the extract showed higher protection than the independent injection of venom, followed by the extract in the mice. However, in both the cases the extract -a cocktail of inhibitors significantly increased the survival time, when compared to that of mice injected (i.p) with the venom alone. These results encourage further studies on the potential use of cocktail of inhibitors in improving the treatment of snake envenomation. Further, this study substantiates the use of M. indica as an antidote against snakebite by the traditional healers.

  3. A Hipparcos study of the Hyades open cluster Improved colour-absolute magnitude and Hertzsprung-Russell diagrams

    CERN Document Server

    De Bruijne, J H J; De Zeeuw, P T; Bruijne, Jos H.J. de; Hoogerwerf, Ronnie

    2001-01-01

    Hipparcos parallaxes fix distances to individual stars in the Hyades cluster with an accuracy of 6%. We use the Hipparcos (and Tycho-2) proper motions, which have a larger relative precision than the trigonometric parallaxes, to derive ~3 times more precise distance estimates, by assuming that all members share the same space motion. The improved parallaxes as a set are statistically consistent with the Hipparcos parallaxes. The new parallaxes confirm that the Hipparcos measurements are correlated on small angular scales, consistent with the limits specified in the Hipparcos Catalogue, though with significantly smaller `amplitudes' than claimed by Narayanan & Gould. The colour-absolute magnitude diagram of the cluster based on the new paral- laxes shows a well-defined main sequence with two gaps/turn-offs. These features provide the first direct observational support of Boehm-Vitense's prediction that (the onset of) surface convection in stars affects their B-V colours. We present and discuss the theoreti...

  4. [Montana MOYOCO Invasive Species Strike Team Final Report 2015] Charles M. Russel National Wildlife Refuge, Benton Lake ISST

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The MOYOCO (MT) Invasive Species Strike Team is made up of two field strike teams, housed at Benton Lake and Lee Metcalf National Wildlife Refuges, yet administered...

  5. [Montana MOYOCO Invasive Species Strike Team Final Report 2016] Charles M. Russel National Wildlife Refuge, Benton Lake ISST

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The MOYOCO (MT) Invasive Species Strike Team is made up of two field strike teams, housed at Benton Lake and Lee Metcalf National Wildlife Refuges, yet administered...

  6. Richard B. Russell Dam and Reservoir: Potential Water Quality Effects of Initial Filling and Decomposition of Vegetation.

    Science.gov (United States)

    1984-01-01

    the retention time of water in the hypo- . limnion and serve to move materials out of the project as soon as they are released rather than permitting...them to accumulate. Influence of oxygen injection on releases 76. Injection of oxygen into releases from the anoxic hypo- limnion of the Richard B

  7. Positioning University as a Brand: Distinctions between the Brand Promise of Russell Group, 1994 Group, University Alliance, and Million+ Universities

    Science.gov (United States)

    Furey, Sheila; Springer, Paul; Parsons, Christine

    2014-01-01

    Branding is now widely used by higher education (HE) institutions, yet questions still surround the transference of private sector concepts to a university context. This article reports on findings from studies that investigated the brand promises of four UK universities--one from each of the HE "mission groups." The evidence indicated…

  8. Natural Fire Regimes and Pre-European Settlement Vegetation of the Charles M. Russell National Wildlife Refgue

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The goal of this project was to develop maps of the historical fire regimes and original vegetation of CMR to provide a background for decisions around restoration...

  9. Searching for Adverse Effects in MEDLINE and EMBASE Requires a Combined Approach for Efficient Retrieval, A review of: Golder, Su, Heather M. McIntosh, Steve Duffy, and Julie Glanville. “Developing Efficient Search Strategies to Identify Reports of Adverse Effects in MEDLINE and EMBASE.” Health Information & Libraries Journal 23.1 (Mar. 2006: 3-12.

    Directory of Open Access Journals (Sweden)

    Marcy L. Brown

    2006-09-01

    Full Text Available Objective – To assess the sensitivity and precision of various search strategies for retrieving adverse effects studies from the MEDLINE and EMBASE databases. Design – Analytical survey. Subjects – A case study using a recently published systematic review of the effectiveness and adverse effects of seven new anti-epileptic drugs. Setting – MEDLINE and EMBASE searches performed by researchers at the Centre for Reviews and Dissemination and the UK Cochrane Centre Search Filters Design Group at the University of York, UK. Methods – Five key approaches to searching were defined. The first approach used either text words or controlled vocabulary to search for specific adverse effects. The second used subheadings or qualifiers either attached to drug names found in the controlled vocabulary (approach 2a or ‘floating’ without drug names (approach 2b. The third approach used text words as synonyms for the phrase ‘adverse effects.’ The fourth used controlled indexing terms for adverse effects. The fifth and final approach used two published search strategies incorporating study design (Badgett et al., Loke et al.. These five approaches were used to search for studies of the adverse effects of seven new anti‐epileptic drugs. 5,011 unique papers were retrieved. Of these, 236 were judged potentially relevant and 225 full text articles were obtained. The inclusion criteria from a previously published systematic review (Wilby et al. were applied to the papers, and 79 met the criteria. Five papers were added to the set after being identified from reference lists, clinical experts, and other sources. This new set of 84 studies was used as a quasi gold standard (QGS against which more than 300 combinations of the five approaches could be tested. To create the set of possible approaches, the researchers combined search strategies one through four in all possible ways, and used all available subheading combinations from 2a and 2b. The Badgett and Loke searches were tested separately. Main Results – Sensitivity and precision were determined for each combination. Formulas used to calculate sensitivity and precision were provided. In MEDLINE, search strategies using floating subheadings achieved the highest sensitivity. The most useful single subheading in both MEDLINE and EMBASE was “adverse effects,” with 79.1% and 79.5% sensitivity respectively. Of the more than 300 combinations tested, the most sensitive combination in MEDLINE included specified adverse effects in combination with the floating subheadings “adverse effects,” “complications,” and “drug effects,” together with text words for adverse effects. This strategy had 97.0% sensitivity, but low precision at 2.8%. The highest precision was achieved by using subheadings attached to drug indexing terms. In EMBASE, the strategy of Loke et al. provided the highest sensitivity at 86.3% and precision of 2.0%. Since researchers are not likely to know in advance all of the reported adverse effects of a particular drug therapy, the most sensitive strategies without specific adverse events were also identified. The search with the highest sensitivity in MEDLINE had 95.5% sensitivity, and 97.3% sensitivity in EMBASE. Conclusion – Searching for adverse effects requires a combination of approaches in both MEDLINE and EMBASE. In MEDLINE, the most sensitive combination yielded 97.0% sensitivity. Regardless of the approach used, precision remains low. An effective generic search filter for adverse effects searches may not yet be feasible. More research is needed on search strategies, as well as more consistent methods of reporting and indexing adverse effects.

  10. Formens fascination

    DEFF Research Database (Denmark)

    Prebensen, Henrik

    2006-01-01

    Sprogvidenskab, matematisk lingvistik, matematik, humaniora, sprogform, Saussure, Frege, Russel, Reichenbach, Chomsky, formalisme, funktionalisme......Sprogvidenskab, matematisk lingvistik, matematik, humaniora, sprogform, Saussure, Frege, Russel, Reichenbach, Chomsky, formalisme, funktionalisme...

  11. Allen Denver Russell Memorial Lecture, 2006. The use of microbicides in infection control: a critical look at safety, testing and applications.

    Science.gov (United States)

    Sattar, S A

    2006-10-01

    Microbial pathogens continue as major threats to health. Indeed, many ongoing societal changes are enhancing our vulnerability and exposure to several frank and opportunistic pathogens. This, together with rampant antimicrobial resistance and reduced prospects for newer drugs and vaccines, is forcing a higher reliance on microbiocides in infection prevention and control. That this reliance may not be well-founded becomes apparent from a closer look at current ways of testing and registering microbiocides, their label claims as well as human and environmental safety of certain widely used microbicidal chemicals. Many methods to test microbiocides for registration are flawed and/or entail test conditions irrelevant to field use. Pathogens listed on product labels may not be among those amenable to interruption through microbiocide use. The wide variations and discrepancies in existing national/regional regulations for registering microbiocides for sale stifle innovation. This is a critical look at the above-mentioned issues with emphasis on chemicals meant for use on environmental surfaces and medical devices. It highlights better ways to test microbiocides and to attain global harmonization of testing and product registration. It also details the known and potential dangers of microbiocide use and what to consider in choosing such formulations for optimal safety and effectiveness. End users are advised to be more critical and prudent in the selection and application of microbicidal chemicals, manufacturers are encouraged to explore infection control products and technologies that are safer in the workplace and for the environment, and regulators are urged to review and update the requirements and procedures for premarket review of microbiocide efficacy data and label claims. Independent investigations are also urgently needed to document the proportion of nosocomial infections that would be amenable to prevention through chemical disinfection of environmental surfaces.

  12. Comment on 'Distribution of whistler mode bursts at Venus' by F.L. Scarf, K.F. Jordan, and C.T. Russell

    Science.gov (United States)

    Taylor, Harry A., Jr.; Kramer, Leonard; Cloutier, Paul A.

    1989-01-01

    Consideration is given to the study of the 100-Hz electric field noise observed from the Pioneer Venus Orbiter (PVO) by Scarf et al. (1987). It is suggested that the study incorrectly interprets the results as evidence for lightning and volcanism at Venus. Statistical evidence is presented, suggesting that the distribution of the noise is essentially random, within the zone of occurrence of ion troughs, and decreases at the lowest PVO altitudes, closest to the neutral atmosphere. It is found that the topographic clustering reported by Scarf et al. is an artifact of the variable spatial distribution of troughs and associated noise.

  13. Farklı parametrizasyon tekniklerinin Saurida lessepsianus (Russell, Golani & Tikochinski, 2015’un von Bertalanffy büyüme parametrelerinin tahminine etkisi

    Directory of Open Access Journals (Sweden)

    Sedat Gündoğdu

    2015-12-01

    Full Text Available Bu çalışmada Saurida lessepsianus’un von Bertalanffy büyüme modeli parametreleri tahminine, farklı parametrizasyon tekniklerinin etkisi incelenmiştir. Bu amaçla Galucci ve Quinn parametrizasyonu, Mooij parametrizasyonu, Francis parametrizasyonu ve Schnute parametrizasyonu kullanılmıştır. Akaike Bilgi Kriteri (AIC, güvenirlik aralıkları ve parametreler arası korelasyonlar yardımıyla modeller karşılaştırılmıştır. Buna göre en uygun parametrizasyon yönteminin Francis parametrizasyon yöntemi olduğu tespit edilmiştir.

  14. Richard B. Russell Dam and Lake, Savannah River, Georgia and South Carolina Final Foundation Report, Concrete Dam, Embankments and Powerhouse. Volume 1. Text and Plates

    Science.gov (United States)

    1989-10-03

    shear zone, showed evidence of hydrotherml alteration and severe weathering. Possibly, the joint allowed easy penetration by hydrothermal solutions... HYDROTHERMALLY ALTERED QFG & EHG p/ ENG CONCRETE 0 oH 4*Mr ENO EW QFMG COWNETE EMSc,- ANOESITE 9 .am colse sme. *A"* - - ecoop VA _______ HA~S JII*to& 3...rock. somatiamu bordered by itetadiabme dikes. Cn mops, this rock is called quartz feldspar porphyry . Ibisenfladi (1977) refers to this rock an a

  15. Farklı parametrizasyon tekniklerinin Saurida lessepsianus (Russell, Golani & Tikochinski, 2015’un von Bertalanffy büyüme parametrelerinin tahminine etkisi

    Directory of Open Access Journals (Sweden)

    Sedat Gündoğdu

    2016-01-01

    Full Text Available Bu çalışmada Saurida lessepsianus’un von Bertalanffy büyüme modeli parametreleri tahminine, farklı parametrizasyon tekniklerinin etkisi incelenmiştir. Bu amaçla Galucci ve Quinn parametrizasyonu, Mooij parametrizasyonu, Francis parametrizasyonu ve Schnute parametrizasyonu kullanılmıştır. Akaike Bilgi Kriteri (AIC, güvenirlik aralıkları ve parametreler arası korelasyonlar yardımıyla modeller karşılaştırılmıştır. Buna göre en uygun parametrizasyon yönteminin Francis parametrizasyon yöntemi olduğu tespit edilmiştir.

  16. Farklı parametrizasyon tekniklerinin Saurida lessepsianus (Russell, Golani & Tikochinski, 2015)’un von Bertalanffy büyüme parametrelerinin tahminine etkisi

    OpenAIRE

    Sedat Gündoğdu; Makbule Baylan

    2016-01-01

    Bu çalışmada Saurida lessepsianus’un von Bertalanffy büyüme modeli parametreleri tahminine, farklı parametrizasyon tekniklerinin etkisi incelenmiştir. Bu amaçla Galucci ve Quinn parametrizasyonu, Mooij parametrizasyonu, Francis parametrizasyonu ve Schnute parametrizasyonu kullanılmıştır. Akaike Bilgi Kriteri (AIC), güvenirlik aralıkları ve parametreler arası korelasyonlar yardımıyla modeller karşılaştırılmıştır. Buna göre en uygun parametrizasyon yönteminin Francis parametrizasyon yöntemi old...

  17. Hypomethylation of the H19 gene causes not only Silver-Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype.

    NARCIS (Netherlands)

    Bliek, J.; Terhal, P.; Bogaard, M.J. van den; Maas, S.; Hamel, B.C.J.; Salieb-Beugelaar, G.; Simon, M.; Letteboer, T.; Smagt, J. van der; Kroes, H.Y.; Mannens, M.

    2006-01-01

    The H19 differentially methylated region (DMR) controls the allele-specific expression of both the imprinted H19 tumor-suppressor gene and the IGF2 growth factor. Hypermethylation of this DMR--and subsequently of the H19 promoter region--is a major cause of the clinical features of gigantism and/or

  18. Meeting Report. Assessing Human Germ-Cell Mutagenesis in thePost-Genome Era: A Celebration of the Legacy of William Lawson (Bill)Russell

    Energy Technology Data Exchange (ETDEWEB)

    Wyrobek, Andrew J.; Mulvihill, John J.; Wassom, John S.; Malling,Heinrich V.; Shelby, Michael D.; Lewis, Susan E.; Witt, Kristine L.; Preston, R. Julian; Perreault-Darney, Sally; Allen, James W.; DeMarini,David M.; Woychik, Richard P.; Bishop Jack B; Workshop Presenters

    2006-04-18

    Although numerous germ-cell mutagens have been identified inanimal model systems, to date, no human germ-cell mutagens have beenconfirmed. Because the genomic integrity of our germ cells is essentialfor the continuation of the human species, a resolution of this enduringconundrum is needed. To facilitate such a resolution, we organized aworkshop at The Jackson Laboratory in Bar Harbor, Maine on September28-30, 2004. This interactive workshop brought together scientists from awide range of disciplines to assess the applicability of emergingmolecular methods for genomic analysis to the field of human germ-cellmutagenesis. Participants recommended that focused, coordinated humangerm-cell mutation studies be conducted in relation to important societalexposures. Because cancer survivors represent a unique cohort withwell-defined exposures, there was a consensus that studies should bedesigned to assess the mutational impact on children born to parents whohad received certain types of mutagenic cancer chemotherapy prior toconceiving their children. Within this high-risk cohort, parents andchildren could be evaluated for inherited changes in (a) gene sequencesand chromosomal structure, (b) repeat sequences and minisatelliteregions, and (c) global gene expression and chromatin. Participants alsorecommended studies to examine trans-generational effects in humansinvolving mechanisms such as changes in imprinting and methylationpatterns, expansion of nucleotide repeats, or induction of mitochondrialDNA mutations. Workshop participants advocated establishment of abio-bank of human tissue samples that could be used to conduct amultiple-endpoint, comprehensive, and collaborative effort to detectexposure-induced heritable alterations in the human genome. Appropriateanimal models of human germ-cell mutagenes is should be used in parallelwith human studies to provide insights into the mechanisms of mammaliangerm-cell mutagenesis. Finally, participants recommended that scientificspecialty groups be convened to address specific questions regarding thepotential germ-cell mutagenicity of environmental, occupational, andlifestyle exposures. Strong support from relevant funding agencies andengagement of scientists outside the fields of genomics and germ-cellmutagenesis will be required to launch a full-scale assault on some ofthe most pressing and enduring questions in environmental mutagenesis: Dohuman germ-cell mutagens exist, what risk do they pose to futuregenerations, and are some parents at higher risk than others foracquiring and transmitting germ-cell mutations?

  19. Evolution of long-lived globular cluster stars III. Effect of the initial helium spread on the position of stars in a synthetic Hertzsprung-Russel diagram

    CERN Document Server

    Chantereau, William; Meynet, Georges

    2016-01-01

    Context. Globular clusters host multiple populations of long-lived low-mass stars whose origin remains an open question. Several scenarios have been proposed to explain the associated photometric and spectroscopic peculiarities. They differ, for instance, in the maximum helium enrichment they predict for stars of the second population, which these stars can inherit at birth as the result of the internal pollution of the cluster by different types of stars of the first population. Aims. We present the distribution of helium-rich stars in present-day globular clusters as it is expected in the original framework of the fast-rotating massive stars scenario (FRMS) as first-population polluters. We focus on NGC 6752. (to be continued)

  20. Evolution of long-lived globular cluster stars III. Effect of the initial helium spread on the position of stars in a synthetic Hertzsprung-Russell diagram

    OpenAIRE

    Chantereau, William; Charbonnel, Corinne; Meynet, Georges

    2016-01-01

    Context. Globular clusters host multiple populations of long-lived low-mass stars whose origin remains an open question. Several scenarios have been proposed to explain the associated photometric and spectroscopic peculiarities. They differ, for instance, in the maximum helium enrichment they predict for stars of the second population, which these stars can inherit at birth as the result of the internal pollution of the cluster by different types of stars of the first population. Aims. We pre...

  1. Serious Games: Defense Advanced Research Projects Agency: An Interview with Innovation Information Office Program Manager CAPT Russell Shilling, PhD.

    Science.gov (United States)

    2012-04-01

    Dr. Shilling received his Doctor of Philosophy in Experimental Psychology (Auditory Psychophysics/Neuroscience) from the University of North Carolina at Greensboro in 1992 and his Bachelor of Arts in Psychology at Wake Forest University in 1985. In 1993 he graduated with top honors from Aerospace Experimental Psychologist training-Naval Flight Surgeon Class 93002. In 1996, he served as an Assistant/Associate Professor at the U.S. Air Force Academy in the Department of Behavioral Sciences and Leadership. In 2000, he arrived at the Naval Postgraduate School as an Associate Professor in the Operations Research and Systems Engineering Departments and became Technical Director for Immersive Technologies in the Modeling, Virtual Environments, and Simulation Institute. His military decorations include the Defense Superior Service Medal, Meritorious Service Medal (three awards), the Navy Commendation Medal, and the Navy Achievement Medal. He is also the recipient of the American Hospital Association's 2009 Executive Award for Excellence.

  2. Testing and Evaluation of the 84 Sites and Reconnaissance of the Islands and Cleveland Property, Richard B. Russell Dam and Lake, Savannah River, Georgia and South Carolina.

    Science.gov (United States)

    1983-08-01

    element might still be largely present. No definite features were found. The site might enable horizontal distributional studies to be made, based on...prior to the beginning of transit mapping, these were also done concurrently with the mapping. 2) A detailed transit map was made of the site area (Figure...working platform. This interpretation was further substantiated by a high density of coal clinkers in this unit and the absence of burned materials in

  3. Evolution of long-lived globular cluster stars. III. Effect of the initial helium spread on the position of stars in a synthetic Hertzsprung-Russell diagram

    Science.gov (United States)

    Chantereau, W.; Charbonnel, C.; Meynet, G.

    2016-08-01

    Context. Globular clusters host multiple populations of long-lived low-mass stars whose origin remains an open question. Several scenarios have been proposed to explain the associated photometric and spectroscopic peculiarities. They differ, for instance, in the maximum helium enrichment they predict for stars of the second population, which these stars can inherit at birth as the result of the internal pollution of the cluster by different types of stars of the first population. Aims: We present the distribution of helium-rich stars in present-day globular clusters as it is expected in the original framework of the fast-rotating massive stars scenario (FRMS) as first-population polluters. We focus on NGC 6752. Methods: We completed a grid of 330 stellar evolution models for globular cluster low-mass stars computed with different initial chemical compositions corresponding to the predictions of the original FRMS scenario for [Fe/H] = -1.75. Starting from the initial helium-sodium relation that allows reproducing the currently observed distribution of sodium in NGC 6752, we deduce the helium distribution expected in that cluster at ages equal to 9 and 13 Gyr. We distinguish the stars that are moderately enriched in helium from those that are very helium-rich (initial helium mass fraction below and above 0.4, respectively), and compare the predictions of the FRMS framework with other scenarios for globular cluster enrichment. Results: The effect of helium enrichment on the stellar lifetime and evolution reduces the total number of very helium-rich stars that remain in the cluster at 9 and 13 Gyr to only 12% and 10%, respectively, from an initial fraction of 21%. Within this age range, most of the stars still burn their hydrogen in their core, which widens the MS band significantly in effective temperature. The fraction of very helium-rich stars drops in the more advanced evolution phases, where the associated spread in effective temperature strongly decreases. These stars even disappear from the horizontal branch and the asymptotic giant branch at 13 Gyr. Conclusions: The helium constraint is no suitable criterion for clearly distinguishing between the scenarios for GC self-enrichment because only few very helium-rich stars are predicted in the investigated framework and because it is difficult to derive the helium content of GC stars observationally. However, the helium constraint indicates some difficulties of the original FRMS scenario that require the exploration of alternatives. The files containing the relevant evolution characteristics of the complete grid of models from the pre-main sequence up to the end of the stellar life (see Appendix of Chantereau et al. 2015) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A111 As in Chantereau et al. (2015), we also provide all the tables on the website http://obswww.unige.ch/Recherche/evol/starevol/Globular.php

  4. Geronimo's Kids: A Teacher's Lessons on the Apache Reservation. Elma Dill Russell Spencer Series in the West and Southwest, No. 16.

    Science.gov (United States)

    Ove, Robert S.; Stockel, H. Henrietta

    In 1948, a young and naive Robert Ove arrived at Whitetail, on the Mescalero Apache Reservation, to teach at the Bureau of Indian Affairs day school. Living there were the Chiricahua Apaches--descendants of Geronimo and the survivors of nearly 30 years of incarceration by the U.S. government. With help from Indian historian H. Henrietta Stockel,…

  5. Comment on 'Distribution of whistler mode bursts at Venus' by F.L. Scarf, K.F. Jordan, and C.T. Russell

    Science.gov (United States)

    Taylor, Harry A., Jr.; Kramer, Leonard; Cloutier, Paul A.

    1989-01-01

    Consideration is given to the study of the 100-Hz electric field noise observed from the Pioneer Venus Orbiter (PVO) by Scarf et al. (1987). It is suggested that the study incorrectly interprets the results as evidence for lightning and volcanism at Venus. Statistical evidence is presented, suggesting that the distribution of the noise is essentially random, within the zone of occurrence of ion troughs, and decreases at the lowest PVO altitudes, closest to the neutral atmosphere. It is found that the topographic clustering reported by Scarf et al. is an artifact of the variable spatial distribution of troughs and associated noise.

  6. Commentary: ADHD and Social Disadvantage: An Inconvenient Truth?--A Reflection on Russell et al. (2014) and Larsson et al. (2014)

    Science.gov (United States)

    Nigg, Joel T.; Craver, Lindsay

    2014-01-01

    In the 1950's, many experts believed hyperkinesis was a neurotic reaction to inner conflicts arising from early family experiences. In the 1990's, many experts believed ADHD to be "genetic" (without a mechanistic explanation of what that meant). Both views appear naïve today in a scientific world grappling with the complexity…

  7. All That Remains. The Traditional Architecture and Historic Engineering Structures, Richard B. Russell Multiple Resource Area, Georgia and South Carolina. Appendix A. The Inventory.

    Science.gov (United States)

    1983-01-01

    homes still in existance. The architectural quality of the building, though deteriorated through vandalism and neglect, is easily detectable and would...o Roag 2 t, en east and nijh nnrn A mlactn X ME F; N CONOOONE 1oOPCIN INDoo ).T EAP in’ -~o >~A, " E~O~ -AEA ~ 0E~OE D-. 16 INUENTORIEDBY ArrDT N A

  8. The Beaverdam Group: Archaeological Investigations at 9EB92, 9EB207, 9EB208 and 9EB219 Richard B. Russell Multiple Resource Area, Elbert County, Georgia.

    Science.gov (United States)

    1984-01-01

    36 Laboratory Methods ........... .................. ..... .. 37 -- Lithic Analysis ................................... 37...historic activity. The majority of the historic items were expended shotgun shells and discarded cans. Lithic Analysis The majority of artifacts...recovered from the Beaverdam Group sites consists of lithic material, most of which is crudely worked. Lithic analysis proceeded on the basis of two

  9. All That Remains: The Traditional Architecture and Engineering Structures of the Richard B. Russel Multiple Resource Area, Georgia and South Carolina. Appendix B.

    Science.gov (United States)

    1983-01-01

    BERRY ( HOWARD UNIVERSITY), DAVID T. MARSH JR. ( HOWARD UNIVERSITY), AND STAFF LANDSCAPE ARCHITECT, PAUL D. DOLUNSKY. GROGAN HOUSE IEUREKA I 500 300...VAS EXECUTED UNDER THE DIRECTION OF ROBNERT ICAPUHCHU 4E OF NAER; JOHN V OF GEORGI ). THE HAS FIELD OFFICE, ELBERTON, GEORGA. ,,TEA PP IRCHE FHBiN

  10. 文学阅读中的医学人文渗透--以Russel Baker作品In My Day为例%Inifltration of Medical Humanism in Literary Reading--A Case Study of Russel Baker’s In My Day

    Institute of Scientific and Technical Information of China (English)

    丁杨; 孔祥国

    2016-01-01

    The enhancement of medical students’ medical humanistic quality is an important factor in the construction of a harmonious doctor-patient relationship and the improvement of therapeutic effect. In language teaching classes like College English, the inifltration of medical humanism in literary reading on the basis of the interpretation of illness narrative and the inspiration of empathy between doctors and patients can effectively help medical students to learn about illness and patients, enhance their empathy and humanistic care consciousness, therefore, it provides new angles and means for the cultivation of medical students’ medical humanistic quality.%医学生医学人文素养的提高是构建和谐医患关系、提升诊疗效果的重要因素,在大学英语等语言类课堂教学中,通过文学阅读渗透医学人文教育,基于疾病叙事的解读和和医患共情的激发,能够有效地帮助医学生认识疾病和病患,增强共情意识和人文关怀意愿,从而为医学生医学人文素养的培育提供新的视角和途径。

  11. 75 FR 58428 - Notice of Inventory Completion: Athens County Historical Society and Museum, Athens, OH

    Science.gov (United States)

    2010-09-24

    ... in a hatbox in the collections storage. According to a former museum curator, the human remains were... contact Heather Reed, Curator/Education Coordinator, Athens County Historical Society and Museum, 65 N...

  12. Plaadid / Aivo Vahemets

    Index Scriptorium Estoniae

    Vahemets, Aivo

    2005-01-01

    Uutest heliplaatidest Jam, Pearl "Rearviewmirror", Sibul, Riho "Must", Seal "Best 1991-2004", Carlton, Vanessa "Harmonium", Live "Awake - The Best Of", Stefani, Gwen "Love. Angel. Music. Baby", Collins, Finghin "Dear Heather"

  13. EPA Recognizes Whole Foods Market in Marietta, Ga for Reducing Food Waste

    Science.gov (United States)

    ATLANTA - Today, U.S. Environmental Protection Agency (EPA) Regional Administrator Heather McTeer Toney recognized the Whole Foods Market Merchant Walk Marietta Store in Georgia for the store's achievements in EPA's Food Recovery Challenge. Whole Fo

  14. Plaadid / Aivo Vahemets

    Index Scriptorium Estoniae

    Vahemets, Aivo

    2005-01-01

    Uutest heliplaatidest Jam, Pearl "Rearviewmirror", Sibul, Riho "Must", Seal "Best 1991-2004", Carlton, Vanessa "Harmonium", Live "Awake - The Best Of", Stefani, Gwen "Love. Angel. Music. Baby", Collins, Finghin "Dear Heather"

  15. Tark raadio / Neil Savage

    Index Scriptorium Estoniae

    Savage, Neil

    2006-01-01

    California Santa Barbara ülikooli infotehnoloogia abiprofessor Heather Zheng tegeleb küsimusega, kuidas traadita seadmeid tõhusamalt eetrisse ära mahutada. Artikkel üldpealkirja all: 10 tulevikutehnoloogiat

  16. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest Juliette And The Licks "Four On The Floor", The Bosshoss "Rodeo Radio", Teriyaki Boys "Beef Or Chicken", Apocalyptica "Amplified", Chieftains "The Essential", Heather Greene "Five Dollar Dress", Teräsbetoni "Vaadimehe metallia"

  17. Pop / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2004-01-01

    Heliplaatidest: Goldie Lookin Chain "Greatest Hits", Placebo "Once More With Feeling - The Singles 1996 to 2004", The Killers "Hot Fuss", Leonard Cohen "Dear Heather", Ray Conniff "The Essenttial Ray Conniff", Neurosis "The Eye Of Every Storm"

  18. Plaadid / Mart Normet

    Index Scriptorium Estoniae

    Normet, Mart, 1979-

    2006-01-01

    Uutest heliplaatidest The Roots "Game Theory", Maarja ja Rannap "Läbi jäätunud klaasi", Natalie Walker " Urban Angel", Outkast "Idlewild", Peter Grant "New Vintage", Stone Sour "Come What May", Heather Greene "Five Dollar Dress"

  19. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest Juliette And The Licks "Four On The Floor", The Bosshoss "Rodeo Radio", Teriyaki Boys "Beef Or Chicken", Apocalyptica "Amplified", Chieftains "The Essential", Heather Greene "Five Dollar Dress", Teräsbetoni "Vaadimehe metallia"

  20. Muusika : Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest: Def Räädu "Planet Duckrabbit", Sõpruse Puiestee "XX sajandi lapsed", Ines "15 magamata ööd", Metro Luminal "Reboot", Helin-Mari Arder "Su aknast näen", Leonard Cohen "Dear Heather"

  1. Mieren in Veluwebermen: soortenrijkdom en aanbevelingen voor beheer (Hymenoptera: Formicidae).

    NARCIS (Netherlands)

    Noordijk, J.; Boer, P.

    2007-01-01

    Ants in roadside verges on the Veluwe: species richness and recommendations for management (Hymenoptera: Formicidae) Highway verges in the Veluwe region contain some well developed nutrient poor plant communities, like grasslands, grey hair grass vegetation and heather vegetation. These places

  2. Plaadid / Mart Normet

    Index Scriptorium Estoniae

    Normet, Mart, 1979-

    2006-01-01

    Uutest heliplaatidest The Roots "Game Theory", Maarja ja Rannap "Läbi jäätunud klaasi", Natalie Walker " Urban Angel", Outkast "Idlewild", Peter Grant "New Vintage", Stone Sour "Come What May", Heather Greene "Five Dollar Dress"

  3. 75 FR 67965 - Announcement of Local Government Advisory Committee Members

    Science.gov (United States)

    2010-11-04

    .... Ronald K. Davis, Mayor, Prichard, Alabama. Adam Ortiz, Mayor, Edmonston, Maryland. Heather McTeer Hudson..., Massachusetts. David W. Smith, Mayor, Newark, California. Tribal (Elected and Appointed) Steve Ortiz,...

  4. Pop / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2004-01-01

    Heliplaatidest: Goldie Lookin Chain "Greatest Hits", Placebo "Once More With Feeling - The Singles 1996 to 2004", The Killers "Hot Fuss", Leonard Cohen "Dear Heather", Ray Conniff "The Essenttial Ray Conniff", Neurosis "The Eye Of Every Storm"

  5. Muusika : Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest: Def Räädu "Planet Duckrabbit", Sõpruse Puiestee "XX sajandi lapsed", Ines "15 magamata ööd", Metro Luminal "Reboot", Helin-Mari Arder "Su aknast näen", Leonard Cohen "Dear Heather"

  6. Tark raadio / Neil Savage

    Index Scriptorium Estoniae

    Savage, Neil

    2006-01-01

    California Santa Barbara ülikooli infotehnoloogia abiprofessor Heather Zheng tegeleb küsimusega, kuidas traadita seadmeid tõhusamalt eetrisse ära mahutada. Artikkel üldpealkirja all: 10 tulevikutehnoloogiat

  7. A System of Third-Order Differential Operators Conformally Invariant under $\\mathfrak{sl}(3,\\mathbb{C})$ and $\\mathfrak{so}(8,\\mathbb{C})$

    CERN Document Server

    Kubo, Toshihisa

    2011-01-01

    In earlier work, Barchini, Kable, and Zierau constructed a number of conformally invariant systems of differential operators associated to Heisenberg parabolic subalgebras in simple Lie algebras. The construction was systematic, but the existence of such a system was left open in two cases, namely, the $\\Omega_3$ system for type $A_2$ and type $D_4$. Here, such a system is shown to exist for both cases. The construction of the system may also be interpreted as giving an explicit homomorphism between generalized Verma modules.

  8. 76 FR 5412 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

    Science.gov (United States)

    2011-01-31

    ... 3, 2007), 72 FR 17963 (April 10, 2007) (SR-ISE-2006-59). The Exchange believes that introducing... Retail Index (MVR); Nasdaq Q- 50 Index (NXTQ); Mini-Russell 2000 (RMN); Russell 1000 Index (RUI); S&P...

  9. 78 FR 27415 - Kansas; Major Disaster and Related Determinations

    Science.gov (United States)

    2013-05-10

    ..., McPherson, Ness, Osage, Osborne, Pawnee, Phillips, Pratt, Rice, Rooks, Rush, Russell, Smith, and..., Marion, McPherson, Ness, Osage, Osborne, Pawnee, Phillips, Pratt, Rice, Rooks, Rush, Russell, Smith, and...

  10. Hætten af for Robin Hood

    DEFF Research Database (Denmark)

    Oxenbøll, Morten

    2010-01-01

    En historisk gennemgang af Robin Hood myten i anledning af den kommende Hood film med Russell Crowe i hovedrollen.......En historisk gennemgang af Robin Hood myten i anledning af den kommende Hood film med Russell Crowe i hovedrollen....

  11. JRHR Vol 8 No 1

    African Journals Online (AJOL)

    USER

    This paper employs the methods of philosophical analysis and hermeneutics to .... philosophy is rendered tellingly and eloquently by Bertrand. Russell .... negative quality of the mind is translated to actions in relations with .... Russell, Bertrand.

  12. 76 FR 39457 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Science.gov (United States)

    2011-07-06

    ... market. \\10\\ The Russell 3000 Value Index measures the performance of the broad value segment of the U.S... forecasted growth values. \\11\\ The Russell 3000 Growth Index measures the performance of the broad growth... ratios and higher forecasted growth values. \\12\\ The Russell 2500 Index measures the performance of...

  13. Joint Global War on Terror (GWOT) Vascular Injury Study 2

    Science.gov (United States)

    2017-02-01

    surveillance program design and identified Service Members who incurred vascular injury. She has left the study. Name: Andrea Russell Project...Role: Research Nurse Nearest person month worked: 36 Contribution to Project: Ms. Andrea Russell assisted in developing the surveillance...program design and continues to identify Service Members who incurred vascular injury for inclusion in the study. Ms. Russell also oversees all

  14. High Speed Surface Thermocouples Interface to Wireless Transmitters

    Science.gov (United States)

    2017-03-15

    Transmitters David Patti 1 Item 6: Eric Gingrich, MS-12 1 RD ECOM-TARDEC-RTI-GVPM Russell Robinson, ACO 1 Item 14, Recipient Destinations: Include completed DD...David Patti: david.m.patti4.civ@mail.mil - Russell Robinson, ACO: russell.robinson@dcma.mil - OTIC (mai l 2 hardcopies) : Defense Technical Information

  15. The Transformation of American Revolutionary Forces

    Science.gov (United States)

    2017-05-25

    grounding in military skills. Historian Russell Weigley asserts that the various militias performed adequately when defending their homes and settlements...outers.” The prevalence of social pariahs 14 Russell F. Weigley, History of the United States Army...Weedon. New York: Arno Press, 1971. Weigley, Russell F. History of the United States Army. Enlarged ed. Bloomington: Indiana University Press, 1984

  16. 75 FR 78302 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-12-15

    ... Contained in the Standard & Poor's 500 Index, Russell 1000 Index, and Specified Exchange Traded Products... individual stocks contained in the Standard & Poor's 500 Index, Russell 1000 Index, and specified Exchange... securities in the Standard & Poor's 500 Index, the Russell 1000 Index, as well as a pilot list of...

  17. 76 FR 19819 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2011-04-08

    ... Contained in the Standard & Poor's 500 Index, Russell 1000 Index, and Specified Exchange Traded Products... contained in the Standard & Poor's 500 Index, Russell 1000 Index, and specified Exchange Traded Products... only apply to securities in the Standard & Poor's 500 Index, the Russell 1000 Index, as well as a...

  18. Combining Psychological Models with Machine Learning to Better Predict People’s Decisions

    Science.gov (United States)

    2012-03-09

    in some applications (Kaelbling, Littman, & Cassandra, 1998; Neumann & Morgenstern, 1944; Russell & Norvig , 2003). However, research into people’s...scientists often model peoples’ decisions through machine learning techniques (Russell & Norvig , 2003). These models are based on statistical methods such as...A., & Kraus, S. (2011). Using aspiration adaptation theory to improve learning. In Aamas (p. 423-430). Russell, S. J., & Norvig , P. (2003

  19. Nobel Prize in Physics 1993 "for the discovery of a new type of pulsar, a discovery that has opened up new possibilities for the study of gravitation" : Russell A. Hulse and Joseph H. Taylor Jr.

    CERN Multimedia

    1994-01-01

    Prof. J. H. Taylor Jr. presents "Binary pulsars and relativistic gravity" Spinning freely on their axes, and emitting radio noise detectable over interastellar distances, pulsars make extraordinarily stable natural clocks. Detailed comparisons of""pulsar time" with time kept by atomic clocks on Earth have opened the way for tests of gravity under conditions much more relativistic than found anywhere within the solar system. Among other results,these experiments have demonstrated the existence,quadrupolar nature, and propagation speed of gravitational waves.

  20. 多种药剂对螺旋粉虱不同虫态的毒力测定%Toxicity of Several Inseccides to Different Stages of Aleurodicus dispersus Russell

    Institute of Scientific and Technical Information of China (English)

    廖永林; 张扬; 曾东强; 黄超福; 李燕芳; 李梅辉; 陈造熊

    2011-01-01

    The toxicity of 30 kinds of insecticides on the adult and 15 kinds of insecticides on the 3rd instar nymph of A leurodicus dispersus were determined by Potter spraying method.The results showed that methidathion,chlorpyrifos, phoxim, malathion, alpha-cypermethrin, deltamethrin, dichlorvos and profenofos had higher toxicity on the adult and 3rd instar nymphs.Methidathion, chlorpyrifos, phoxim, malathion, alpha-cypermethrin, deltamethrin,dichlorvos and profenofos got higher toxicity on the adult with LC50 of 0.912 3, 1.571 4, 1.673 1, 2.248 2, 2.557 0, 3.039 1, 3.186 8 and 4.189 5 mg/L, respectively.Deltamethrin, methidathion, chlorpyrifos, lambda-cyhalothrin and betacypermethrin got higher toxicity on the instar nymph with LC50 of 8.527 6, 11.486 5, 12.950 3, 12.973 8 and 13.7036 mg/L,respectively.The sensitivity of different instar nymph to 8 kinds of insecticides was measured with Potter spraying method.The results indicated that the 1st instar nymph had higher than 2-4 instar nymph, and the 4 instar nymph had the less sensiticity.%采用Potter喷雾法,测定30种杀虫剂对螺旋粉虱成虫与15种杀虫剂对螺旋粉虱若虫的毒力.结果表明:杀扑磷、毒死蜱、辛硫磷、溴氰菊酯、马拉硫磷等对成虫、若虫均具有较高活性.对成虫杀扑磷毒力最强,其LC50值为0.9123 mg/L,毒死蜱、辛硫磷、马拉硫磷、顺式氯氰菊酯、溴氰菊酯、敌敌畏及丙溴磷对成虫毒力均较高,其LC50值分别为1.571 4、1.673 1、2.248 2、2.557 0、3.039 1、3.186 8、4.1895 mg/L.对若虫溴氰菊酯毒力最强,其LC20值为8.527 6 mg/L,杀扑磷、毒死蜱、高效氯氟氰菊酯、高效氯氰菊酯对若虫同样具有较高毒力,其LC50值分别为11.486 5、12.950 3、12.973 8、13.703 6 mg/L.另通过不同龄期若虫对毒死蜱等8种杀虫剂的敏感性测定,发现1~4龄若虫对杀虫剂的敏感性随虫龄增加而降低,1龄若虫最敏感,2龄和3龄若虫的敏感性相当,4龄若虫敏感性最低.

  1. Integrative Paths to the Past: Paleoanthropological Advances in Honor of F. Clark Howell, edited by Robert S. Corrnccini and Russell L. Ciochon, Englewood Cliffs, New Jersey: Prentice-Hall, 1994.

    Directory of Open Access Journals (Sweden)

    Pamela R. Willoughby

    1995-11-01

    Full Text Available F. Clark Howell retired from the faculty of the University of California at Berkeley in 1991. At Berkeley, and earlier while at the University of Chicago, he was responsible for training a number of specialists in human biocultural evolution, or palaeoanthropology. In fact, Howell is credited with developing the concept of palaeoanthropology (and defining the term itself; he certainly created the framework for this integrated, multi-disciplinary approach to human evolution. For his retirement, former students and colleagues collaborated to produce this volume. Some of the papers were presented at a one day symposium reviewing the highlights of Howell's career along with current research directions in palaeoanthropology. It took place during the annual meeting of the American Anthropological Association held in San Francisco in 1992. Bowell's long time colleague J. Desmond Clark gave the distinguished lecture at the same meeting. During his career, Howell directed excavations at Isimilain Tanzania, as well as Torralba and Ambrona in Spain (all extensive Acheulean localities, but is best known for his work west of the Omo River in southern Ethiopia. It was there during the 1960s and 1970s that he developed the methods and approaches which would come to characterize the best of palaeoanthropological research.

  2. The Banister Allen Plantation (38AB102) and Thomas B. Clinkscales Farm: (38AB221) Data Recovery in the Richard B. Russell Multiple Resource Area Abbeville County, South Carolina.

    Science.gov (United States)

    1983-01-01

    than with Structure A. In addition to the glass and bottle fragments noted above, pecan and hickory nut shells, ": the fluted clay pipe bowl fragment...variety of artifact classes suggestive of secondary deposition some distance away from the immediate habitation area of Structure B: a button, nut ...increased its representation in the archaeological record is immaterial, since the Clinkscales house was abandoned, and if it ever had glazed windows

  3. 持续创新共享未来——访沙伯基础创新塑料聚碳酸酯业务负责人 William D Russell 先生

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    沙特基础工业公司是世界主要石化产品公司之一,产品包括聚乙烯、聚丙烯、高级热塑性材料、糖醇、甲醇和肥料等。沙特基础工业公司的重要战略业务部门——沙伯基础创新塑料是全球领先的工程热塑性材料供应商,在为客户提供突破性解决方案方面拥有80年的经验。公司通过与客户协作以及不断投资开发新型聚合物技术、全球应用开发、工艺技术以及满足汽车、电子、建筑、运输与保健等多个行业需求的环保型解决方案,持续在塑料行业保持较大的优势。公司的产品品种繁多,包括热塑性树脂、涂层、特种复合材料、薄膜与板材等。在Chinaplas 2011国际橡塑展上,本刊采访了沙伯基础创新塑料聚碳酸酯业务负责人William D Russell先生,对其在中国市场的业务状况有了进一步的了解。

  4. Community Adult Education; Evidence Submitted to the Russell Committee on Adult Education in England and Wales by the Workers' Educational Association (West Lancashire & Cheshire District) and the Liverpool Educational Priority Area Action/Research Project.

    Science.gov (United States)

    Lovett, T. O.

    This paper discusses six roles which an adult education agency can fill in an Educational Priority Area and illustrates each one with examples from the Liverpool E.P.A. Project. These roles are: (1) adult education cum community development; (2) adult education as a resource in community development work; (3) adult education as an aid to parents…

  5. Proposed additions to the National Wilderness Preservation System : Part 35 : Deferred Areas : Kofa Game Range - Charles M. Russell National Wildlife Range - Lake Mead National Recreation Area - Nunivak National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is one of the Presidential Transmittals proposing additions to the National Wilderness Preservation System. This particular transmittal focuses on the...

  6. Comment on 'Observations of reconnection of interplanetary and lobe magnetic field lines at the high-latitude magnetopause' by J.T. Gosling, M.F. Thomsen, S.J. Bame, R.C. Elphic, and C.T. Russell

    Science.gov (United States)

    Belen'kaia, Elena

    1993-01-01

    Comment is presented on the results of measurements, reported by Gosling et al. (1991), that were made on ISEE in the vicinity of the high-latitude dusk magnetopause near the terminator plane, at a time when the local magnetosheath and tail lobe magnetic fields were nearly oppositely directed. The character of the observed plasma flowing both tailward and sunward within the high-latitude magnetopause current layer presented real evidence for the local reconnection process. Gosling et al. argued that this process may be a manifestation of different global magnetospheric topology structures. In the comment, a global magnetospheric convection pattern is constructed for the northward IMF and for the case of a large azimuthal component of the IMF with small Bz, irrespective of its sign. The suggested scheme provides a simple explanation for the observed sunward convection in the polar caps both for the northward and for strong By with small Bz. According to the present model, for the magnetosheath field at 2300 UT on June 11, 1978, the reconnection between the open field lines appears at the northern neutral point.

  7. Education and the National Question Today. Essay Reviews: "Nationalism in Education," edited by Klaus Schleicher; "Dogmatic Wisdom: How the Culture Wars Divert Education and Distract America," by Russell Jacoby; "Blood and Belonging: Journeys into the New Nationalism," by Michael Ignatieff.

    Science.gov (United States)

    Post, David

    1995-01-01

    Reviews three books concerned with the role of education either in constructing new nationalist identities or in promoting global awareness and pluralistic attitudes. Distinguishes between multicultural education in elementary and secondary schools and separatist ethnic studies in universities. Points out the appeal of nationalist and ethnic…

  8. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2005-01-01

    Full Text Available Sitor Situmorang, Toba na Sae; Sejarah lembaga sosial politik abad XIII-XX (Johann Angerler Raul Pertierra, Science, technology, and everyday culture in the Philippines (Greg Bankoff Françoise Gérard and François Ruf (eds, Agriculture in crisis; People, commodities and natural resources in Indonesia, 1996-2000 (Peter Boomgaard Kennet Sillander, Acting authoritatively; How authority is expressed through social action among the Bentian of Indonesian Borneo (Aurora Donzelli Kathleen M. Nadeau, Liberation theology in the Philippines; Faith in a revolution (Gareth Fisher Roy Ellen, On the edge of the Banda Zone; Past and present in the social organization of a Moluccan trading network (Gregory Forth Roy Ellen, On the edge of the Banda Zone; Past and present in the social organization of a Moluccan trading network (J.M. Gullick I.H.N. Evans, Bornean diaries, 1938-1942 (Fiona Harris S. Margana, Kraton Surakarta dan Yogyakarta 1769-1874 (Mason C. Hoadley Henry Frei, Guns of February; Ordinary Japanese soldiers’ views of the Malayan campaign and the fall of Singapore 1941-42 (Russell Jones Gerrit Knaap and Heather Sutherland, Monsoon traders; Ships, skippers and commodities in eighteenth-century Makassar (J. Thomas Lindblad David W. Fraser and Barbara G. Fraser, Mantles of merit; Chin textiles from Myanmar, India and Bangladesh (Sandra A. Niessen Kees Snoek, E. du Perron; Het leven van een smalle mens (Frank Okker Arthur J. Dommen, The Indochinese experience of the French and the Americans; Nationalism and communism in Cambodia, Laos and Vietnam (Vatthana Pholsena J.H.M.C. Boelaars and A.C. Blom, Mono Koame; ‘Wij denken ook’ (Anton Ploeg James J. Fox and Dionisio Babo Soares (eds, Out of the ashes; Destruction and reconstruction of East Timor (Johanna van Reenen Anke Niehof and Firman Lubis (eds, Two is enough; Family planning in Indonesia under the New Order 1968-1998 (Elisabeth Schr

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2001-07-01

    societies of color in the nineteenth century. Baton Rouge: Louisiana State University Press, 1998. xxii + 227 pp. -Alvin O. Thompson, Maurice St. Pierre, Anatomy of resistance: Anti-colonialism in Guyana 1823-1966. London: Macmillan, 1999. x + 214 pp. -Linda Peake, Barry Munslow, Guyana: Microcosm of sustainable development challenges. Aldershot, U.K. and Brookfield VT: Ashgate, 1998. x + 130 pp. -Stephen Stuempfle, Peter Mason, Bacchanal! The carnival culture of Trinidad. Philadelphia PA: Temple University Press, 1998. 191 pp. -Christine Chivallon, Catherine Benoît, Corps, jardins, mémoires: Anthropologie du corps et de l' espace à la Guadeloupe. Paris: CNRS Éditions, 2000. 309 pp. -Katherine E. Browne, Mary C. Waters, Black identities: Wsst Indian immigrant dreams and American realities. New York: Russell Sage Foundation; Cambridge MA: Harvard University Press, 1999. xvii + 413 pp. -Eric Paul Roorda, Bernardo Vega, Los Estados Unidos y Trujillo - Los días finales: 1960-61. Colección de documentos del Departamento de Estado, la CIA y los archivos del Palacio Nacional Dominicano. Santo Domingo: Fundación Cultural Dominicana, 1999. xx+ 783 pp. -Javier Figueroa-de Cárdenas, Charles D. Ameringer, The Cuban democratic experience: The Auténtico years, 1944-1952. Gainesville: University Press of Florida, 2000. ix + 230 pp. -Robert Lawless, Charles T. Williamson, The U.S. Naval mission to Haiti, 1959-1963. Annapolis MD: Naval Institute Press, 1999. xv + 395 pp. -Noel Leo Erskine, Arthur Charles Dayfoot, The shaping of the West Indian Church, 1492-1962. Kingston: The Press University of the West Indies; Gainesville: University Press of Florida, 1999. xvii + 360 pp. -Edward Baugh, Laurence A. Breiner, An introduction to West Indian poetry. Cambridge: Cambridge University Press, 1998. xxii + 261 pp. -Lydie Moudileno, Heather Hathaway, Caribbean waves: Relocating Claude McKay and Paule Marshall. Bloomington: Indiana University Press, 1999. xi + 201 pp. -Nicole Roberts

  10. Compositional Modeling with DPNs

    Science.gov (United States)

    2007-11-02

    Technical Report Compositional Modeling with DPNs 6. AUTHOR(S) Geoffrey Zweig and Stuart Russell 7. PERFORMING ORGANIZATION NAMES(S) AND ADDRESS(ES...Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. 239-18 298-102 Compositional Modeling With DPNs Geoffrey Zweig Stuart Russell Report No. UCB...Modeling With DPNs Geoffrey Zweig * Stuart Russell * Sept. 8, 1997 Abstract Dynamic probabilistic networks (DPNs) are a powerful and efficient method for

  11. Economic instruments for solid waste management in South Africa: opportunities and constraints

    CSIR Research Space (South Africa)

    Nahman, Anton

    2009-01-01

    Full Text Available (Nahman, 2009). 4 countries, where they appear to have some important advantages over CAC (Pearce and Turner, 1994; Bell and Russell, 2002; Inter-American Development Bank, 2003). These include cost effectiveness, promotion of economic efficiency... negatively on competitiveness and equity) will be politically unpopular. These conditions are unlikely to be fulfilled in many developing countries (Bell and Russell, 2002; Russell and Vaughan, 2003), where CAC mechanisms therefore continue to dominate...

  12. Joint Exercise Program: DOD Needs to Take Steps to Improve the Quality of Funding Data

    Science.gov (United States)

    2017-02-01

    Cary B. Russell at (202) 512-5431 or russellc@gao.gov. Why GAO Did This Study The Joint Exercise Program is the principal means for combatant...contributors to this report are listed in appendix V. Cary B. Russell Director Defense Capabilities and Management Page 23 GAO-17-7...Exercise Program Appendix V: GAO Contact and Staff Acknowledgments Page 36 GAO-17-7 Joint Exercise Program Cary B. Russell , (202) 512

  13. Angelic Hierarchical Planning: Optimal and Online Algorithms

    Science.gov (United States)

    2008-12-06

    restrict our attention to plans in I∗(Act, s0). Definition 2. ( Parr and Russell , 1998) A plan ah∗ is hierarchically optimal iff ah∗ = argmina∈I∗(Act,s0):T...Murdock, Dan Wu, and Fusun Yaman. SHOP2: An HTN planning system. JAIR, 20:379–404, 2003. Ronald Parr and Stuart Russell . Reinforcement Learning with...Angelic Hierarchical Planning: Optimal and Online Algorithms Bhaskara Marthi Stuart J. Russell Jason Wolfe Electrical Engineering and Computer

  14. A United Framework for Solving Multiagent Task Assignment Problems

    Science.gov (United States)

    2007-12-01

    Intelligent automation and soft computing, 5:5–19, 1999. 98. Parr , Ronald and Stuart Russell . “Reinforcement Learning with Hierarchies of Machines...Problems Optimally, Efficiently and Asynchronously”. Proceedings of AAMAS. 2003. 94. Murphy, Robin Roberson, Christine Laetitia Lisetti, Russell ...update”. European Journal of Operational Research, 174:23–37, 2006. 103. Russell , Stuart and Peter Norvig. Artificial Intelligence: A Modern Approach

  15. Modeling Behavior and Variation for Crowd Animation

    Science.gov (United States)

    2009-08-01

    Stuart J. Russell . The BATmobile: Towards a bayesian automated taxi. In IJCAI, pages 1878–1885, 1995. 2.4 [23] Jeffrey Forbes, Nikunj Oza, Ronald Parr ...and Stuart Russell . Feasibility study of fully au- tomated traffic using decision-theoretic control, 1997. Cal. PATH Research Report UCB- ITS-PRR-97...18, Inst. of Transportation Studies, U. C. Berkeley. 2.4 [24] Nir Friedman, Kevin Murphy, and Stuart Russell . Learning the structure of dynamic

  16. Short-Sighted Probabilistic Planning

    Science.gov (United States)

    2013-08-01

    approaches mentioned so far is applied by t-look- ahead [Pearl, 1985, Russel and Norvig , 2003] and Upper Confidence bound for Trees (UCT) [Kocsis and...Symbiotic Human-Robot Interaction. In Proc. of the 9th Int. Joint Conf. on Autonomous Agents and Multiagent Systems (AAMAS). [Russel and Norvig , 2003...Russel, S. J. and Norvig , P. (2003). Artificial Intelligence - A Modern Approach. Prentice Hall, 2nd edition. [Samadi et al., 2012] Samadi, M., Kollar, T

  17. Modeling Cyber Situational Awareness Through Data Fusion

    Science.gov (United States)

    2013-03-01

    through a medium. Described by Russell and Norvig [39], a simpler method of expressing the transition between states is to look at the state transition...Diagram Russell and Norvig [39] further explain MDP as a process that can decide on an optimal state based on a previous state in a stochastic...Russell and Norvig [39] explain that planning in artificial intelligence is a method to find a set of actions to achieve a goal. This is accomplished

  18. Methods for Reachability-based Hybrid Controller Design

    Science.gov (United States)

    2012-05-10

    Markov Decision Processes (see for example Russell and Norvig , 2002; Thrun et al., 2005). Given a finite state space, the state transition kernel ν can be...distribution p0 and the information vector ik. The update equations for pk|k can be found in for example Chapter 17 of Russell and Norvig (2002) or...for POMDP problems to find the optimal control policy (Russell and Norvig , 2002, Chapter 17; Thrun et al., 2005, Chapter 15). However, as shown by

  19. Bayesian Logic Programs for Plan Recognition and Machine Reading

    Science.gov (United States)

    2012-12-01

    representing relational domains involving several objects, their properties, and their relationships with other objects (Russell & Norvig , 2003). A term in...Russell & Norvig , 2003) from a specified query (SLD resolution) to obtain all possible de- ductive proofs for the query. In the context of the current task...IJCAI 1995), pp. 1146–1152, Montreal, Canada. Russell, S., & Norvig , P. (2003). Artificial Intelligence: A Modern Approach (2 edition). Prentice Hall

  20. Understanding Optimal Decision-Making in Wargaming

    Science.gov (United States)

    2013-10-01

    previously (Russell & Norvig , 2010). The perception 8 Figure 2.3: Information processing model of human cognition (C. Wickens & Hollands, 2000). Dotted...decision-making (Perla, 1990). 9 Figure 2.4: Agent environment interaction (Russell & Norvig , 2010). 2.2. Neurophysiological Measures The study of...selection while balancing exploration and exploitation (Sutton & Barto, 1998; Russell & Norvig , 2010). For our purposes, with our version of the IGT

  1. The Multi-Intelligence Tools Suite - Supporting Research and Development in Information and Knowledge Exploitation

    Science.gov (United States)

    2011-06-01

    mechanisms must operate on representations of facts, rather than on the facts themselves [Russell, Norvig , 1995]. The object of knowledge representation...KR) is to express knowledge in computer-tractable form, such that it can be exploited [Russell, Norvig , 1995]. KR and reasoning is the area of...related to the sentences of English and other natural languages, but is not identical [Russell, Norvig , 1995]. Sentences in logic are intended to

  2. 78 FR 26679 - Kansas Disaster #KS-00073

    Science.gov (United States)

    2013-05-07

    ..., Dickinson, Ellis, Franklin, Harper, Harvey, Hodgeman, Kingman, Marion, Mcpherson, Ness, Osage, Osborne, Pawnee, Phillips, Pratt, Rice, Rooks, Rush, Russell, Smith, Stafford. The Interest Rates are: Percent For...

  3. Water flow through the polypropylene-based geotextiles.

    CSIR Research Space (South Africa)

    Patanaik, A

    2008-06-01

    Full Text Available velocity data obtained from water permeability test and theo- retical prediction based on FEA. References 1. Mao, N.; Russell, S. J. J Textile Inst 2000, 91, 235. 2. Mao, N.; Russell, S. J. J Textile Inst 2000, 91, 244. 3. Sullivan, R. R.; Hertel, K.... 7. Patnaik, A.; Rengasamy, R. S.; Kothari, V. K.; Ghosh, A. Wet- ting and Wicking in Fibrous Materials; Textile Progress; Wood- head Publishing: Cambridge, UK, 2006. 8. Mao, N.; Russell, S. J.; Pourdeyhimi, B. In Russell, S. J., Eds.; Woodhead...

  4. 77 FR 49440 - Membership of the Performance Review Board

    Science.gov (United States)

    2012-08-16

    ... Pontius Angela Rogers James Russell Dennis Savage Richard Sayre Steven Schleien Donna Seymour David... Johnson Kevin Kelly Paul Koffsky Paul Kozemchak Roberta Lowe Nathan Maenle Richard Mccormick...

  5. Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The Netherlands.

    NARCIS (Netherlands)

    Wielinga, Peter R; Gaasenbeek, Cor; Fonville, Manoj; Boer, Albert de; Vries, Ankje de; Dimmers, Wim; Akkerhuis Op Jagers, Gerard; Schouls, Leo M; Borgsteede, Fred; Giessen, Joke W B van der

    2006-01-01

    From 2000 to 2004, ticks were collected by dragging a blanket in four habitat areas in The Netherlands: dunes, heather, forest, and a city park. Tick densities were calculated, and infection with Borrelia burgdorferi and Anaplasma and Ehrlichia species was investigated by reverse line blot analysis.

  6. Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in the Netherlands

    NARCIS (Netherlands)

    Wielinga, P.R.; Gaasenbeek, C.P.H.; Fonville, M.; Boer, de A.G.; Vries, de A.; Dimmers, W.J.; Jagers op Akkerhuis, G.A.J.M.; Schouls, L.M.; Borgsteede, F.H.M.; Giessen, van der J.W.B.

    2006-01-01

    From 2000 to 2004, ticks were collected by dragging a blanket in four habitat areas in The Netherlands: dunes, heather, forest, and a city park. Tick densities were calculated, and infection with Borrelia burgdorferi and Anaplasma and Ehrlichia species was investigated by reverse line blot analysis.

  7. The Secret Identity of Science Education: Masculine and Politically Conservative?

    Science.gov (United States)

    Lemke, Jay

    2011-01-01

    This response to Jesse Bazzul and Heather Sykes' paper, "The secret identity of a biology textbook: straight and naturally sexed," explores their critiques of textbooks and curricula that authoritatively present scientific accounts of the natural world without engaging students in critical thinking. It proposes that we need to go beyond such…

  8. Cultural Tourism in Transnational Adoption: "Staged Authenticity" and Its Implications for Adopted Children

    Science.gov (United States)

    Quiroz, Pamela Anne

    2012-01-01

    The discursive practices of adoptive parents in two online transnational adoption forums (2006-2008) and observations of five international adoption workshops suggest that what Heather Jacobson described as "culture keeping", the cultural socialization of children that retains a sense of native group identity, is more aptly characterized as…

  9. Chasing Rainbows: A Comment on School Choice and the National Football League

    Science.gov (United States)

    Beal, Brent D.; Olson Beal, Heather K.

    2013-01-01

    In this article, Brent Beal, and Heather Olson Beal respond to comments made about their article: "Rethinking the Market Metaphor: School Choice, the Common Good, and the National Football League," appearing in this issue of the Journal of School Choice. Comments were made by Vitteritti, Houck, Coulson, Bast, and Merrifield. In their…

  10. Het geslacht Stereocaulon (Lichenes) in Nederland

    NARCIS (Netherlands)

    Brand, A.M.; Sipman, H.J.M.

    1978-01-01

    Eight Stereocaulon (Lichenes) species have been found in the Netherlands. Of these S. paschale (L.) Fr. and S. tomentosum Fr. have been observed only in the last century, in heather and woodland on sand. S. condensatum Hoffm. is found on old drifted sands in the interior, where it occurs now and is

  11. Addressing Army Aviation Collective Training Challenges with Simulators and Simulations Capabilities

    Science.gov (United States)

    2012-08-01

    Aptima, Inc. Technical Review by William Bickley, U.S. Army Research Institute Heather Priest-Walker, U.S. Army Research Institute...training challenges at home station and at Aviation Training Exercises. This report benefitted from the thoughtful comments of Drs. William Bickley and...environment, cockpit instrumentation, communications, weapons systems, gunnery environment, AH64 TADS , NVG (Night Vision Goggles) Simulation, EDMs

  12. Cultural Tourism in Transnational Adoption: "Staged Authenticity" and Its Implications for Adopted Children

    Science.gov (United States)

    Quiroz, Pamela Anne

    2012-01-01

    The discursive practices of adoptive parents in two online transnational adoption forums (2006-2008) and observations of five international adoption workshops suggest that what Heather Jacobson described as "culture keeping", the cultural socialization of children that retains a sense of native group identity, is more aptly characterized as…

  13. Can nutrient status of four woody plant species be predicted using field spectrometry?

    NARCIS (Netherlands)

    Ferwerda, J.G.; Skidmore, A.K.

    2007-01-01

    This paper demonstrates the potential of hyperspectral remote sensing to predict the chemical composition (i.e., nitrogen, phosphorous, calcium, potassium, sodium, and magnesium) of three tree species (i.e., willow, mopane and olive) and one shrub species (i.e., heather). Reflectance spectra, deriva

  14. Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in the Netherlands

    NARCIS (Netherlands)

    Wielinga, P.R.; Gaasenbeek, C.P.H.; Fonville, M.; Boer, de A.G.; Vries, de A.; Dimmers, W.J.; Jagers op Akkerhuis, G.A.J.M.; Schouls, L.M.; Borgsteede, F.H.M.; Giessen, van der J.W.B.

    2006-01-01

    From 2000 to 2004, ticks were collected by dragging a blanket in four habitat areas in The Netherlands: dunes, heather, forest, and a city park. Tick densities were calculated, and infection with Borrelia burgdorferi and Anaplasma and Ehrlichia species was investigated by reverse line blot analysis.

  15. Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The Netherlands.

    NARCIS (Netherlands)

    Wielinga, Peter R; Gaasenbeek, Cor; Fonville, Manoj; Boer, Albert de; Vries, Ankje de; Dimmers, Wim; Akkerhuis Op Jagers, Gerard; Schouls, Leo M; Borgsteede, Fred; Giessen, Joke W B van der

    2006-01-01

    From 2000 to 2004, ticks were collected by dragging a blanket in four habitat areas in The Netherlands: dunes, heather, forest, and a city park. Tick densities were calculated, and infection with Borrelia burgdorferi and Anaplasma and Ehrlichia species was investigated by reverse line blot analysis.

  16. Adding Scents to Symbols: Using Food Fragrances with Deafblind Young People Making Choices at Mealtimes

    Science.gov (United States)

    Murdoch, Heather; Gough, Anne; Boothroyd, Eileen; Williams, Kate

    2014-01-01

    This article is written by Heather Murdoch, research consultant for the Seashell Trust, Anne Gough, deputy headteacher at Royal School Manchester/Seashell Trust, Eileen Boothroyd, consultant for the Seashell Trust, and Kate Williams, a creative perfumer for Seven (PZ Cussons). It describes the use of food fragrances with deafblind students who are…

  17. Diagnosis and management of feline hyperthyroidism: current perspectives

    OpenAIRE

    Vaske HH; Schermerhorn T; Armbrust L; Grauer GF

    2014-01-01

    Heather H Vaske, Thomas Schermerhorn, Laura Armbrust, Gregory F Grauer Department of Clinical Sciences, Kansas State University, Manhattan, KS, USA Abstract: Previous and ongoing research has provided insights to the pathophysiology and diagnosis of hyperthyroidism as well as new treatment modalities. This paper reviews the etiology, clinical presentation, and clinicopathologic changes associated with hyperthyroidism, and provides a thorough explanation of confirmatory testing and treatment ...

  18. Agricultural Warfare and Bioterrorism using Invasive Species

    Science.gov (United States)

    The chapter on Agricultural Warfare and Bioterrorism using Invasive Species is part of the book titled Pest Management and Phytosanitary Trade Barriers authored by Neil Heather (Australia) and Guy Hallman. The chapter attempts to briefly put the topic into context with phytosanitation. It presents...

  19. 77 FR 75153 - Notice of Receipt of Pesticide Products; Registration Applications To Register New Uses

    Science.gov (United States)

    2012-12-19

    ...: Fungicide. Proposed Uses: Seed treatment for use on potato; and potato, wet peel. Contact: Heather Garvie... Ingredient: Fluxapyroxad. Product Type: Fungicide. Proposed Uses: Seed treatment use on Brassica vegetables... stable fly larvae in cattle barns and horse barns; control of litter beetles in poultry...

  20. On Twitter, Donald Trump has been paying little lip service to issues important to women.

    OpenAIRE

    2016-01-01

    Throughout the presidential election campaign Heather Evans, Kayla Brown, and Tiffany Wimberly have collected and coded tweets from both Hillary Clinton and Donald Trump. In their latest analysis, and in light of the release of the ‘Trump tapes’ this weekend, they find that Trump is largely ignoring ‘female issues’ while Clinton has talked about them significantly more often.

  1. Discrimination of Polish unifloral honeys using overall PTR-MS and HPLC fingerprints combined with chemometrics

    NARCIS (Netherlands)

    Kus, P.M.; Ruth, van S.M.

    2015-01-01

    A total of 62 honey samples of six floral origins (rapeseed, lime, heather, cornflower, buckwheat and black locust) were analysed by means of proton transfer reaction mass spectrometry (PTR-MS) and HPLC-DAD. The data were evaluated by principal component analysis and k-nearest neighbours classificat

  2. Learning from Teacher Observations: Challenges and Opportunities Posed by New Teacher Evaluation Systems

    Science.gov (United States)

    Hill, Heather C.; Grossman, Pam

    2013-01-01

    In this article, Heather C. Hill and Pam Grossman discuss the current focus on using teacher observation instruments as part of new teacher evaluation systems being considered and implemented by states and districts. They argue that if these teacher observation instruments are to achieve the goal of supporting teachers in improving instructional…

  3. Adding Scents to Symbols: Using Food Fragrances with Deafblind Young People Making Choices at Mealtimes

    Science.gov (United States)

    Murdoch, Heather; Gough, Anne; Boothroyd, Eileen; Williams, Kate

    2014-01-01

    This article is written by Heather Murdoch, research consultant for the Seashell Trust, Anne Gough, deputy headteacher at Royal School Manchester/Seashell Trust, Eileen Boothroyd, consultant for the Seashell Trust, and Kate Williams, a creative perfumer for Seven (PZ Cussons). It describes the use of food fragrances with deafblind students who are…

  4. 77 FR 65404 - Notice of Inventory Completion: Maxwell Museum of Anthropology, University of New Mexico...

    Science.gov (United States)

    2012-10-26

    ... National Park Service Notice of Inventory Completion: Maxwell Museum of Anthropology, University of New... Anthropology. Repatriation of the human remains to the Indian tribe stated below may occur if no additional.... ADDRESSES: Dr. Heather Edgar, Maxwell Museum of Anthropology, MSC01 1050, University of New...

  5. 77 FR 65403 - Notice of Inventory Completion: Maxwell Museum of Anthropology, University of New Mexico...

    Science.gov (United States)

    2012-10-26

    ... National Park Service Notice of Inventory Completion: Maxwell Museum of Anthropology, University of New... to be culturally affiliated with the human remains may contact the Maxwell Museum of Anthropology.... Heather Edgar, Maxwell Museum of Anthropology, MSC01 1050, University of New Mexico, Albuquerque, NM...

  6. 77 FR 46116 - Notice of Inventory Completion: Maxwell Museum of Anthropology, University of New Mexico...

    Science.gov (United States)

    2012-08-02

    ...-1100-665] Notice of Inventory Completion: Maxwell Museum of Anthropology, University of New Mexico... Anthropology has completed an inventory of human remains in consultation with the appropriate Indian tribe, and... Museum of Anthropology at the address below by September 4, 2012. ADDRESSES: Heather Edgar,...

  7. Determination of the surface drag coefficient

    DEFF Research Database (Denmark)

    Mahrt, L.; Vickers, D.; Sun, J.L.

    2001-01-01

    This study examines the dependence of the surface drag coefficient on stability, wind speed, mesoscale modulation of the turbulent flux and method of calculation of the drag coefficient. Data sets over grassland, sparse grass, heather and two forest sites are analyzed. For significantly unstable ...

  8. Media and Young Children's Learning

    Science.gov (United States)

    Kirkorian, Heather L.; Wartella, Ellen A.; Anderson, Daniel R.

    2008-01-01

    Electronic media, particularly television, have long been criticized for their potential impact on children. One area for concern is how early media exposure influences cognitive development and academic achievement. Heather Kirkorian, Ellen Wartella, and Daniel Anderson summarize the relevant research and provide suggestions for maximizing the…

  9. Heathland and the palynology of prehistoric barrows. Reflections on the interrelation between soil formation and pollen infiltration.

    NARCIS (Netherlands)

    Groenman-van Waateringe, W; Spek, Mattheus

    2016-01-01

    In the sandy areas of the Netherlands, heather (Calluna vulgaris) played an important role in the construction of prehistoric barrows, although, as will be shown in this paper, not in all periods as was recently asserted by Doorenbosch (2013). Since the mineralogical composition and the texture of t

  10. Museum makes room for the Big Bang

    CERN Multimedia

    Pinnell, Heather

    2007-01-01

    "Heather Pinnell discovers that a small exhibition about the Large Hadron Collider scored very highly for its impact." The museum has plans to add a spark chamber into the gallery to show that the experiments done at CERM are safe. (2/3 page)

  11. 77 FR 60434 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-03

    ... Type: New OFF License. Farkas Worldwide Shipping Inc. (NVO), 1420 W. Flager Street, Miami, FL 33135, Officers: Heather R. Farkas, President (QI), Maria A. Farkas, Secretary, Application Type: New NVO License... License. Mota Import Export LLC dba MTI Mota Import Export Cargo Express (NVO), 175 Smith Street,...

  12. 78 FR 61370 - National Vaccine Injury Compensation Program; List of Petitions Received

    Science.gov (United States)

    2013-10-03

    ... Federal Claims No: 13-0574V 26. Heather and Matthew Scheidegger on behalf of Troy Scheidegger, Boca Raton.... Mordichai and Chana Pshemish on behalf of Y.P., Boca Raton, Florida, Court of Federal Claims No: 13-0612V 46...

  13. Students Try to Break Taboo around Social Class on Campus

    Science.gov (United States)

    Sander, Libby

    2013-01-01

    When Heather Berg arrived at the University of Virginia in the fall of 2011, she was struck by the seemingly posh lifestyle many of her fellow students enjoyed. Now finishing her second year, she has friends who also felt that culture shock at first. But it's been hard to find them, and to speak candidly with anyone about the impact of money--or…

  14. Mieren in Veluwebermen: soortenrijkdom en aanbevelingen voor beheer (Hymenoptera: Formicidae).

    NARCIS (Netherlands)

    Noordijk, J.; Boer, P.

    2007-01-01

    Ants in roadside verges on the Veluwe: species richness and recommendations for management (Hymenoptera: Formicidae) Highway verges in the Veluwe region contain some well developed nutrient poor plant communities, like grasslands, grey hair grass vegetation and heather vegetation. These places provi

  15. Private-sector caesarean sections in perspective

    African Journals Online (AJOL)

    2005-02-28

    Feb 28, 2005 ... zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand. N Engl J Med ... Cape Town. Heather McLeod, BBusSc, CFA, FIA, FASSA .... future, the required service level agreements will most likely specifically ...

  16. A Response to Cole and Mendick: Interpretation, Misrepresentation and Misrecognition

    Science.gov (United States)

    Moore, Rob

    2006-01-01

    In this article, the author presents his views on Mike Cole's and Heather Mendick's comments on his book titled "Education and Society: Issues and Explanations in the Sociology of Education." In his review, Cole stated that the author's critical realism is seen as an advance on Marxism, of which the author is dismissive. The author refutes that…

  17. Case study - human body relay race.

    Science.gov (United States)

    Lewis, Heather

    2017-04-01

    This case presentation introduces the work of Heather Lewis, Graphic Designer from Birmingham Community Healthcare Foundation Trust, Clinical Illustration department. The graphic design team offer professional design solutions in a variety of formats such as scientific posters, banners, patient information booklets and promotional items. This particular project was requested by the Combined Community Dental Service, a Specialist Division in Birmingham.

  18. Can a District-Level Teacher Salary Incentive Policy Improve Teacher Recruitment and Retention? Policy Brief 13-4

    Science.gov (United States)

    Hough, Heather J.; Loeb, Susanna

    2013-01-01

    In this policy brief, Heather Hough and Susanna Loeb examine the effect of the Quality Teacher and Education Act of 2008 (QTEA) on teacher recruitment, retention, and overall teacher quality in the San Francisco Unified School District (SFUSD). They provide evidence that a salary increase can improve a school district's attractiveness within their…

  19. Take it or leave it

    DEFF Research Database (Denmark)

    With texts from Christine van Assche, Heather Barton, Hans Belting, Raymond Bellour, Dan Cameron, Sabine Fabo, Solange Farkas, Ursula Frohne, Jörg Heiser, Wulf Herzogenrath, Kathy Rae Huffman, Slavko Kacunko, Doris Krystof, Friedemann Malsch, Kobena Mercer, Yvonne Spielmann, Paul Virilio Marcel O...

  20. Role of sand lizards in the ecology of Lyme and other tick-borne diseases in the Netherlands

    Directory of Open Access Journals (Sweden)

    Spitzen - van der Sluijs Annemarieke

    2010-05-01

    Full Text Available Abstract Background Lizards are considered zooprophylactic for almost all Borrelia burgdorferi species, and act as dilution hosts in parts of North America. Whether European lizards significantly reduce the ability of B. burgdorferi to maintain itself in enzootic cycles, and consequently decrease the infection rate of Ixodes ricinus ticks for B. burgdorferi and other tick-borne pathogens in Western Europe is not clear. Results Ticks were collected from sand lizards, their habitat (heath and from the adjacent forest. DNA of tick-borne pathogens was detected by PCR followed by reverse line blotting. Tick densities were measured at all four locations by blanket dragging. Nymphs and adult ticks collected from lizards had a significantly lower (1.4% prevalence of B. burgdorferi sensu lato, compared to questing ticks in heath (24% or forest (19%. The prevalence of Rickettsia helvetica was significantly higher in ticks from lizards (19% than those from woodland (10% whereas neither was significantly different from the prevalence in ticks from heather (15%. The prevalence of Anaplasma and Ehrlichia spp in heather (12% and forest (14% were comparable, but significantly lower in ticks from sand lizards (5.4%. The prevalence of Babesia spp in ticks varied between 0 and 5.3%. Tick load of lizards ranged from 1 - 16. Tick densities were ~ 5-fold lower in the heather areas than in woodlands at all four sites. Conclusions Despite their apparent low reservoir competence, the presence of sand lizards had insignificant impact on the B. burgdorferi s.l. infection rate of questing ticks. In contrast, sand lizards might act as reservoir hosts for R. helvetica. Remarkably, the public health risk from tick-borne diseases is approximately five times lower in heather than in woodland, due to the low tick densities in heather.