WorldWideScience

Sample records for k-9 program overview

  1. K9 Buddies: A Program of Guide Dogs for the Blind

    Science.gov (United States)

    Ritter, Joanne

    2007-01-01

    Today, exceptional dogs that have been specially bred and socialized are paired with children who are blind or visually impaired. These dogs, called "K9 Buddies," are from Guide Dogs for the Blind, a national nonprofit organization with a mission to offer skilled mobility dogs and training free-of-charge to adults with visual impairments…

  2. Validation and Development of a Certification Program for Using K9s to Survey Desert Tortoises

    Science.gov (United States)

    2013-08-01

    Esque, and K. Nussear. Humans vs. K9s: Is fear warranted in the race to save the desert tortoise? 91st Annual Ecological Society of America , August 6-11...desert tortoises, other reptiles (Schwartz et al., 1984; Engeman et al., 1998), or even to 10 distinguish cancer in human subjects (McCulloch et...has yet to be validated in mammals. Therefore, it is not possible to explain precisely how dogs use scent to find desert tortoises, other reptiles

  3. Human Reliability Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  4. Acquisition Support Program Overview

    Science.gov (United States)

    2016-06-30

    Principles of Effective Acquisition © 2006 by Carnegie Mellon University page 31 Summary The SEI, through the Acquisition Support Program , works directly...2006 by Carnegie Mellon University page 1 Acquisition Support Program Overview Brian Gallagher Director, Acquisition Support Program 9 March, 2006...MAR 2006 2. REPORT TYPE 3. DATES COVERED 00-00-2006 to 00-00-2006 4. TITLE AND SUBTITLE Acquisition Support Program Overview 5a. CONTRACT

  5. BMDO photovoltaics program overview

    Science.gov (United States)

    Caveny, Leonard H.; Allen, Douglas M.

    1994-01-01

    This is an overview of the Ballistic Missile Defense Organization (BMDO) Photovoltaic Program. Areas discussed are: (1) BMDO advanced Solar Array program; (2) Brilliant Eyes type satellites; (3) Electric propulsion; (4) Contractor Solar arrays; (5) Iofee Concentrator and Cell development; (6) Entech linear mini-dome concentrator; and (7) Flight test update/plans.

  6. LANL HED Programs Overview

    Energy Technology Data Exchange (ETDEWEB)

    Flippo, Kirk Adler [Los Alamos National Laboratory

    2015-04-23

    The Powerpoint presentation provides an overview of High-Energy Density (HED) Physis, ICF and Burning Plasma research programs at Los Alamos National Lab. in New Mexico. Work in nuclear diagnostics is also presented, along with a summary of collaborations and upcoming projects.

  7. NREL biofuels program overview

    Energy Technology Data Exchange (ETDEWEB)

    Mielenz, J.R. [National Renewable Energy Laboratory, Golden, CO (United States)

    1996-09-01

    The NREL Biofuels Program has been developing technology for conversion of biomass to transportation fuels with support from DOE Office of Transportation Technologies Biofuels System Program. This support has gone to both the National Renewable Energy Laboratory, and over 100 subcontractors in universities and industry. This overview will outline the value of the Biofuels development program to the Nation, the current status of the technology development, and what research areas still need further support and progress for the development of a biofuels industry in the US.

  8. Federal Energy Management Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2017-08-05

    Brochure offers an overview of the Federal Energy Management Program (FEMP), which provides agencies and organizations with the information, tools, and assistance they need to achieve their energy-related requirements and goals through specialized initiatives.

  9. K9传奇

    Institute of Scientific and Technical Information of China (English)

    周文峰

    2004-01-01

    @@ 源远流长的家世 K9这个说法我们中国人不大熟悉,对其意思也不甚明了,但是,在美国、俄罗斯等国,K9却是一个非常大众化的用词.实际上,"K9"就是指警犬和军犬.

  10. Overview of communications programs

    Science.gov (United States)

    Depaula, Ramon P.

    1991-01-01

    The objective of the communications program is to advance critical areas of enabling and enhancing communication technologies that support commercial needs, science, and exploration missions for the 1990's and beyond. The technology program consists of research and technology development in the following areas: RF technology; digital technology; optical communications; mobile communications; and systems integration, test, and evaluation.

  11. 2007 Biomass Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    The Biomass Program is actively working with public and private partners to meet production and technology needs. With the corn ethanol market growing steadily, researchers are unlocking the potential of non-food biomass sources, such as switchgrass and forest and agricultural residues. In this way, the Program is helping to ensure that cost-effective technologies will be ready to support production goals for advanced biofuels.

  12. Hydrogen program overview

    Energy Technology Data Exchange (ETDEWEB)

    Gronich, S. [Dept. of Energy, Washington, DC (United States). Office of Utility Technologies

    1997-12-31

    This paper consists of viewgraphs which summarize the following: Hydrogen program structure; Goals for hydrogen production research; Goals for hydrogen storage and utilization research; Technology validation; DOE technology validation activities supporting hydrogen pathways; Near-term opportunities for hydrogen; Market for hydrogen; and List of solicitation awards. It is concluded that a full transition toward a hydrogen economy can begin in the next decade.

  13. Better Plants Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-09-30

    The U.S. Department of Energy’s (DOE’s) Better Buildings, Better Plants Program is a voluntary partnership initiative to drive significant energy efficiency improvement across energy intensive companies and organizations. 157 leading manufacturers and public water and wastewater treatment utilities are partnering with DOE through Better Plants to improve energy efficiency, slash carbon emissions, and cut energy costs.

  14. Geothermal energy program overview

    Science.gov (United States)

    1991-12-01

    The mission of the Geothermal Energy Program is to develop the science and technology necessary for tapping our nation's tremendous heat energy sources contained within the Earth. Geothermal energy is a domestic energy source that can produce clean, reliable, cost-effective heat and electricity for our nation's energy needs. Geothermal energy - the heat of the Earth - is one of our nation's most abundant energy resources. In fact, geothermal energy represents nearly 40 percent of the total U.S. energy resource base and already provides an important contribution to our nation's energy needs. Geothermal energy systems can provide clean, reliable, cost-effective energy for our nation's industries, businesses, and homes in the form of heat and electricity. The U.S. Department of Energy's (DOE) Geothermal Energy Program sponsors research aimed at developing the science and technology necessary for utilizing this resource more fully. Geothermal energy originates from the Earth's interior. The hottest fluids and rocks at accessible depths are associated with recent volcanic activity in the western states. In some places, heat comes to the surface as natural hot water or steam, which have been used since prehistoric times for cooking and bathing. Today, wells convey the heat from deep in the Earth to electric generators, factories, farms, and homes. The competitiveness of power generation with lower quality hydrothermal fluids, geopressured brines, hot dry rock, and magma (the four types of geothermal energy), still depends on the technical advancements sought by DOE's Geothermal Energy Program.

  15. Commercial Crew Development Program Overview

    Science.gov (United States)

    Russell, Richard W.

    2011-01-01

    NASA's Commercial Crew Development Program is designed to stimulate efforts within the private sector that will aid in the development and demonstration of safe, reliable, and cost-effective space transportation capabilities. With the goal of delivery cargo and eventually crew to Low Earth Orbit (LEO) and the International Space Station (ISS) the program is designed to foster the development of new spacecraft and launch vehicles in the commercial sector. Through Space Act Agreements (SAAs) in 2011 NASA provided $50M of funding to four partners; Blue Origin, The Boeing Company, Sierra Nevada Corporation, and SpaceX. Additional, NASA has signed two unfunded SAAs with ATK and United Space Alliance. This paper will give a brief summary of these SAAs. Additionally, a brief overview will be provided of the released version of the Commercial Crew Development Program plans and requirements documents.

  16. Radioisotope Power Systems Program: A Program Overview

    Science.gov (United States)

    Hamley, John A.

    2016-01-01

    NASA's Radioisotope Power Systems (RPS) Program continues to plan, mature research in energy conversion, and partners with the Department of Energy (DOE) to make RPS ready and available to support the exploration of the solar system in environments where the use of conventional solar or chemical power generation is impractical or impossible to meet potential future mission needs. Recent programs responsibilities include providing investment recommendations to NASA stakeholders on emerging thermoelectric and Stirling energy conversion technologies and insight on NASA investments at DOE in readying a generator for the Mars 2020 mission. This presentation provides an overview of the RPS Program content and status and the approach used to maintain the readiness of RPS to support potential future NASA missions.

  17. Photovoltaic Energy Program overview: Fiscal year 1994

    Science.gov (United States)

    1995-03-01

    This is the 1994 overview for the Photovoltaic (PV) Energy Program. The topics of this overview include cooperative research projects to improve PV systems and develop precommercial prototypes of new PV products, expanding understanding of the fundamental mechanisms governing the formation and performance of PV materials, and helping US industry enhance its leadership position in the PV market.

  18. Overview of the Project Prometheus Program

    Science.gov (United States)

    Burdick, G. M.

    2003-01-01

    This presentation will give an overview of the Project Prometheus Program (PPP, formerly the Nuclear Systems Initiative, NSI) and the Jupiter Icy Moons Orbiter (JIMO) Project (a component of PPP), a mission to the three icy Galilean moons of Jupiter.

  19. Building Technologies Program Multi-Year Program Plan Program Overview 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan Program Overview 2008, including market overview and federal role, program vision, mission, design and structure, and goals and multi-year targets.

  20. Adult Literacy Programs: An Overview.

    Science.gov (United States)

    Newman, Anabel P.

    1994-01-01

    This article examines the broad array of adult literacy program alternatives currently available. These include government-funded adult education programs, such as Adult Basic Education and Even Start, volunteer programs such as Laubach Literacy Action and Literacy Volunteers of America, business and industry sponsored programs, community-based…

  1. Geothermal Technologies Program Overview - Peer Review Program

    Energy Technology Data Exchange (ETDEWEB)

    Milliken, JoAnn [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-06

    This Geothermal Technologies Program presentation was delivered on June 6, 2011 at a Program Peer Review meeting. It contains annual budget, Recovery Act, funding opportunities, upcoming program activities, and more.

  2. Overview of DOE space nuclear propulsion programs

    Science.gov (United States)

    Newhouse, Alan R.

    1993-01-01

    An overview of Department of Energy space nuclear propulsion programs is presented in outline and graphic form. DOE's role in the development and safety assurance of space nuclear propulsion is addressed. Testing issues and facilities are discussed along with development needs and recent research activities.

  3. Air Force Phillips Laboratory Battery Program overview

    Science.gov (United States)

    House, Shaun

    1992-01-01

    Battery development and testing efforts at Phillips Laboratory fall into three main categories: nickel hydrogen, sodium sulfur, and solid state batteries. Nickel hydrogen work is broken down into a Low Earth Orbit (LEO) Life Test Program, a LEO Pulse Test Program, and a Hydrogen Embrittlement Investigation. Sodium sulfur work is broken down into a Geosynchronous Earth Orbit (GEO) Battery Flight Test and a Hot Launch Evaluation. Solid state polymer battery work consists of a GEO Battery Development Program, a Pulse Power Battery Small Business Innovation Research (SBIR), and an in-house evaluation of current generation laboratory cells. An overview of the program is presented.

  4. Space Propulsion Technology Program Overview

    Science.gov (United States)

    Escher, William J. D.

    1991-01-01

    The topics presented are covered in viewgraph form. Focused program elements are: (1) transportation systems, which include earth-to-orbit propulsion, commercial vehicle propulsion, auxiliary propulsion, advanced cryogenic engines, cryogenic fluid systems, nuclear thermal propulsion, and nuclear electric propulsion; (2) space platforms, which include spacecraft on-board propulsion, and station keeping propulsion; and (3) technology flight experiments, which include cryogenic orbital N2 experiment (CONE), SEPS flight experiment, and cryogenic orbital H2 experiment (COHE).

  5. A topaz international program overview

    Science.gov (United States)

    Thome, Frank V.; Wyant, Francis J.; Mulder, Daniel; McCarson, T. D.; Ponomarev-Stepnoi, Nikolai Nikolaevich

    1995-01-01

    Five years ago, during the 8th Symposium on Space Nuclear Power Systems, in Albuquerque, NM, Academician Nikolai Nikolaevich Ponomarev-Stepnoi, First Deputy Director of the Russian Research Center, Kurchatov Institute, proposed the sale of the Soviety Union's TOPAZ II technology to the United States. This proposal, made at great personal risk, was initially viewed with much skepticism by most Americans attending that conference since the Cold War was still in full swing. There were, however, a few visionaries, some would say fanatics, that set about to make this sale possible. Even these visionaries did not anticipate the collapse of the Soviet Union or the subsequent efforts by the U.S. and other Western powers to help the Newly Independent States transition to a market economy. Little did these visionaries know that the formation of the ``TOPAZ II Program,'' using former military space power technology of the Soviet Union, would become the preeminent example of technology cooperation between two former adversaries. A unique teaming arrangement formed in New Mexico, called the New Mexico Strategic Alliance and consisting of the Air Force Phillips Laboratory, Sandia National Laboratories, the University of New Mexico, and Los Alamos Nationalo Laboratory, was a key ingredient in making this program a success. A brief summary of some of the highlights of this technology partnership is given to explain how international patnerships of this type can enable commercialization and technology transfer.

  6. The ESCOMPTE program: an overview

    Science.gov (United States)

    Cros, B.; Durand, P.; Cachier, H.; Drobinski, Ph.; Fréjafon, E.; Kottmeier, C.; Perros, P. E.; Peuch, V.-H.; Ponche, J.-L.; Robin, D.; Saı̈d, F.; Toupance, G.; Wortham, H.

    2004-01-01

    In this paper, the "Expérience sur Site pour COntraindre les Modèles de Pollution atmosphérique et de Transport d'Emissions" (ESCOMPTE) program is presented. The ESCOMPTE program is used to produce a relevant set of data for testing and evaluating regional pollution models. It includes high-resolution (in space and time) atmospheric emission inventories and field experiments, and covers an area of 120×120 km, centered over the Marseilles-Berre area in the southeast of France during Summer 2001. This region presents a high occurrence of photochemical pollution events, which result from numerous industrial and urban sources of primary pollutants. From the dynamical characteristics of the area, sea-breeze circulation and channeling effects due to terrain features highly influence the location of the pollutant plumes. ESCOMPTE will provide a highly documented framework for dynamics and chemistry studies. Campaign strategies and experimental set up are described. During the planning phase, existing modeling results helped defining the experimental design. The campaign involved surface measurement networks, remote sensing, ship-borne, balloon-borne, and airplane measurements. Mean standard meteorological parameters and turbulent fluxes, ozone, ozone precursors, photochemically active trace gases, and aerosols were measured. Five intensive observation periods (IOPs) were documented using a wide spectrum of instruments, involving aircraft (7) (one of them equipped with a Doppler lidar, the others for in situ meteorological and chemical measurements), constant volume balloons (33), ozone lidars (5), wind profilers (15 sodars and radars), Doppler scanning lidar (1), radiosonde systems (at 4 locations), instrumented ships (2). In addition to the air quality networks from environmental agencies, 15 supplementary ground stations equipped for chemistry and/or meteorology and/or surface flux measurements, were operational. All instruments were calibrated and compared during a

  7. K9的由来

    Institute of Scientific and Technical Information of China (English)

    张四峰

    2015-01-01

    <正>K9在美国、俄罗斯等国,是一个非常大众化的用词。实际上,"K9"就是指警犬和军犬。这个称呼还有一段来历。第二次世界大战时,美国看到第一次世界大战期间军犬在战场上发挥的巨大作用,于是也开始组建自己的拥有2万只军犬的特种部队,用于执行侦察、放哨、探测地雷、警卫等军事任务。但是,如何给这支部队编号呢?于是就有人想到犬的英文单词Canine的谐音K9。这个编号深受官方和公众的欢迎,很快就风靡开来。在美

  8. K9巡逻队

    Institute of Scientific and Technical Information of China (English)

    朱英

    2015-01-01

    某警察局以其精锐的警犬部队(即K9巡逻队)而闻名,但在最近的一次行动中却遭遇了尴尬。一个金发女子下班回到家中,发现自己的家被洗劫一空,感到非常震惊。她立即打电话向警察局报案。

  9. NASA Space Cryocooler Programs: A 2003 Overview

    Science.gov (United States)

    Ross, R. G., Jr.; Boyle, R. F.; Kittel, P.

    2004-01-01

    Mechanical cryocoolers represent a significant enabling technology for NASA's Earth and Space Science missions. An overview is presented of ongoing cryocooler activities within NASA in support of current flight projects, near-term flight instruments, and long-term technology development. NASA programs in Earth and space science observe a wide range of phenomena, from crop dynamics to stellar birth. Many of the instruments require cryogenic refrigeration to improve dynamic range, extend wavelength coverage, and enable the use of advanced detectors. Although, the largest utilization of coolers over the last decade has been for instruments operating at medium to high cryogenic temperatures (55 to 150 K), reflecting the relative maturity of the technology at these temperatures, important new developments are now focusing at the lower temperature range from 4 to 20 K in support of studies of the origin of the universe and the search for planets around distant stars. NASA's development of a 20K cryocooler for the European Planck spacecraft and its new Advanced Cryocooler Technology Development Program (ACTDP) for 6-18 K coolers are examples of the thrust to provide low temperature cooling for this class of missions.

  10. Overview Of Federal And State Programs

    Science.gov (United States)

    Snow, Frank J.

    1981-01-01

    Energy audits are a major component of a number of Federal and State energy conservation programs. To various degrees, these programs provide an opportunity for the application of infrared remote sensing (thermography) to the conduct of these audits. The following programs are reviewed and an indication given of how each might make use of infrared as an audit tool: o Residential Conservation Service Program o Schools and Hospitals Program o Federal Energy Management Program o State Energy Grants Program o Weatherization Assistance Program o Energy Extension Service Program o Industrial Energy Conservation Program

  11. Use of K9 units in healthcare: a history.

    Science.gov (United States)

    Sarnese, Paul M

    2016-01-01

    The use of K9 units within healthcare facilities will continue to increase as the violence within healthcare increases. K9s are a wise investment and are cost-effective. K9 units deter and prevent crime and violence at facilities. The typical K9 will be utilized for eight to ten years. The research demonstrates that facilities that have deployed K9 units have seen a reduction in crime and violence. A well trained K9 can not only patrol the exterior of a healthcare facility but also the patient care and service areas. As more hospitals and healthcare facilities look at non-lethal weapons to protect their officers, staff and guests, the use of K9 within healthcare will continue to rise.

  12. Human Genome Program Report. Part 1, Overview and Progress

    Science.gov (United States)

    1997-11-01

    This report contains Part 1 of a two-part report to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 consists of the program overview and report on progress.

  13. Human genome program report. Part 1, overview and progress

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report contains Part 1 of a two-part report to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 consists of the program overview and report on progress.

  14. Photovoltaic Energy Program overview, fiscal year 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The US Department of Energy (DOE) Photovoltaic Energy Program fosters the widespread acceptance of photovoltaic (PV) technology and accelerates commercial use of US PV products. The Program is founded on a collaborative strategy involving industry, the research and development community, potential users, utilities, and state and federal agencies. There are three main Program elements: Systems Engineering and Applications, Technology Development, and Research and Development.

  15. Program Review Rating Scales: Introduction and Overview.

    Science.gov (United States)

    2003

    "Safe and Sound: An Educational Leader's Guide to Evidence-Based Social and Emotional Learning Programs" introduces the concepts of SEL and comprehensive approaches to SEL, describes the value of such programming to the essential academic mission of schools, and suggests how to approach implementing such programming. This packet contains the…

  16. K9初级课堂 关于K9 sports的基础问题

    Institute of Scientific and Technical Information of China (English)

    sunbird

    2006-01-01

    K9训练营已经开办近一年,小编是越来越了解这个K9 sports,进而越来越喜欢,于是想做得更专业,却不小心进入一个误区,很多新读者看着小编每次报道的K9比赛难免一头雾水,心中有个大大的问号,到底什么是K9 sports呀?本期K9训练营就来解答新读者们的疑惑,也为以后咱K9 sports更好地发展开个好头!

  17. Photovoltaic Energy Program Overview Fiscal Year 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    Significant activities in the National Photovoltaic Program are reported for each of the three main program elements. In Research and Development, advances in thin-film materials and crystalline silicon materials are described. The Technology Development report describes activities in photovoltaic manufacturing technology, industrial expansion, module and array development, and testing photovoltaic system components. Systems Engineering and Applications projects described include projects with government agencies, projects with utilities, documentation of performance for international applications, and product certification.

  18. Nasa's Planetary Geologic Mapping Program: Overview

    Science.gov (United States)

    Williams, D. A.

    2016-06-01

    NASA's Planetary Science Division supports the geologic mapping of planetary surfaces through a distinct organizational structure and a series of research and analysis (R&A) funding programs. Cartography and geologic mapping issues for NASA's planetary science programs are overseen by the Mapping and Planetary Spatial Infrastructure Team (MAPSIT), which is an assessment group for cartography similar to the Mars Exploration Program Assessment Group (MEPAG) for Mars exploration. MAPSIT's Steering Committee includes specialists in geological mapping, who make up the Geologic Mapping Subcommittee (GEMS). I am the GEMS Chair, and with a group of 3-4 community mappers we advise the U.S. Geological Survey Planetary Geologic Mapping Coordinator (Dr. James Skinner) and develop policy and procedures to aid the planetary geologic mapping community. GEMS meets twice a year, at the Annual Lunar and Planetary Science Conference in March, and at the Annual Planetary Mappers' Meeting in June (attendance is required by all NASA-funded geologic mappers). Funding programs under NASA's current R&A structure to propose geological mapping projects include Mars Data Analysis (Mars), Lunar Data Analysis (Moon), Discovery Data Analysis (Mercury, Vesta, Ceres), Cassini Data Analysis (Saturn moons), Solar System Workings (Venus or Jupiter moons), and the Planetary Data Archiving, Restoration, and Tools (PDART) program. Current NASA policy requires all funded geologic mapping projects to be done digitally using Geographic Information Systems (GIS) software. In this presentation we will discuss details on how geologic mapping is done consistent with current NASA policy and USGS guidelines.

  19. Industrial Advanced Turbine Systems Program overview

    Energy Technology Data Exchange (ETDEWEB)

    Esbeck, D.W. [Solar Turbines Inc., San Diego, CA (United States)

    1995-10-01

    The U.S. Department of Energy (DOE), in partnership with industry, has set new performance standards for industrial gas turbines through the creation of the Industrial Advanced Turbine System Program. Their leadership will lead to the development of an optimized, energy efficient, and environmentally friendly gas turbine power systems in this size class (3-to-20 MW). The DOE has already created a positive effect by encouraging gas turbine system manufacturers to reassess their product and technology plans using the new higher standards as the benchmark. Solar Turbines has been a leader in the industrial gas turbine business, and is delighted to have joined with the DOE in developing the goals and vision for this program. We welcome the opportunity to help the national goals of energy conservation and environmental enhancement. The results of this program should lead to the U.S. based gas turbine industry maintaining its international leadership and the creation of highly paid domestic jobs.

  20. Overview of NRC PRA research program

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-02-01

    The NRC`s research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements.

  1. 24 CFR 3286.5 - Overview of installation program.

    Science.gov (United States)

    2010-04-01

    ... authorized by the Act to oversee the system established by the regulations in this part, as the Secretary... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Overview of installation program. 3286.5 Section 3286.5 Housing and Urban Development Regulations Relating to Housing and Urban...

  2. Geothermal Program Overview: Fiscal Years 1993-1994

    Energy Technology Data Exchange (ETDEWEB)

    1995-11-01

    Geothermal energy represents the largest U.S. energy resource base and already provides an important contribution to our nation's energy needs. This overview looks at the basic science behind the various geothermal technologies and provides information on DOE Geothermal Energy Program activities and accomplishments.

  3. 40 CFR 63.90 - Program overview.

    Science.gov (United States)

    2010-07-01

    ... appropriate. For accidental release prevention programs, the criteria of § 63.95 must be met in addition to... prevention requirements, noticing, field inspections, entry, sampling, or accidental release prevention... validated according to EPA Method 301 (Part 63, Appendix A) to demonstrate that it provides equal or...

  4. The Utility Battery Storage Systems Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    Utility battery energy storage allows a utility or customer to store electrical energy for dispatch at a time when its use is more economical, strategic, or efficient. The UBS program sponsors systems analyses, technology development of subsystems and systems integration, laboratory and field evaluation, and industry outreach. Achievements and planned activities in each area are discussed.

  5. Data systems and computer science programs: Overview

    Science.gov (United States)

    Smith, Paul H.; Hunter, Paul

    1991-01-01

    An external review of the Integrated Technology Plan for the Civil Space Program is presented. The topics are presented in viewgraph form and include the following: onboard memory and storage technology; advanced flight computers; special purpose flight processors; onboard networking and testbeds; information archive, access, and retrieval; visualization; neural networks; software engineering; and flight control and operations.

  6. Navy SBIR/STTR Program Overview

    Science.gov (United States)

    2012-08-08

    Innova <ve  Research  Program   –  2.6...3%  of  RDT&E  in  FY2012,  rising  to  .45%  for  FY2016   •  Programs  Fund   Innova <ve,  High  Tech  Research  with... innova <ve  R&D  that  meets  a  DoN  Need   –  Transi<on  that  technology  to  a  DoN  plaeorm/  system   • 

  7. An overview of the SAFSIM computer program

    Energy Technology Data Exchange (ETDEWEB)

    Dobranich, D.

    1993-01-01

    SAFSIM (System Analysis Flow SIMulator) is a FORTRAN computer program that provides engineering simulations of user-specified flow networks at the system level. It includes fluid mechanics, heat transfer, and reactor dynamics capabilities. SAFSIM provides sufficient versatility to allow the simulation of almost any flow system, from a backyard sprinkler system to a clustered nuclear reactor propulsion system. In addition to versatility, speed and robustness are primary goals of SAFSIM development. The current capabilities of SAFSIM are summarized and some sample applications are presented. It is applied here to a nuclear thermal propulsion system and nuclear rocket engine test facility.

  8. Overview of Sandia's electric vehicle battery program

    Science.gov (United States)

    Clark, R. P.

    1993-11-01

    Sandia National Laboratories is actively involved in several projects which are part of an overall Electric Vehicle Battery Program. Part of this effort is funded by the United States Department of Energy/Office of Transportation Technologies (DOE/OTT) and the remainder is funded through the United States Advanced Battery Consortium (USABC). DOE/OTT supported activities include research and development of zinc/air and sodium/sulfur battery technologies as well as double layer capacitor (DLC) R&D. Projects in the USABC funded work include lithium/polymer electrolyte (LPE) R&D, sodium/sulfur activities and battery test and evaluation.

  9. Efficient separations and processing crosscutting program overview

    Energy Technology Data Exchange (ETDEWEB)

    Gerdes, K.D. [Department of Energy, Germantown, MD (United States); Harness, J.L. [Department of Energy, Oak Ridge, TN (United States); Kuhn, W.L. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-10-01

    The US Department of Energy (DOE) established the Office of Science and Technology (formerly the Office of Technology Development), as part of the Office of Environmental Management (EM) in November 1989. EM manages remediation of all DOE sites and wastes from current operations. The goal of the EM program is to minimize risks to human health, safety, and the environment and to bring all DOE sites into compliance with federal, state, and local regulations by the year 2019. The Office of Science and Technology (EM-50) is charged with developing and implementing new technologies that are safer, faster, more effective, and less expensive than current methods. To focus resources and address opportunities, EM-50 has targeted four major remediation and waste management problem areas within the DOE complex for action based on risk, prevalence, or need for technology development to meet environmental requirements and regulations. Other areas may be added or current areas further partitioned to ensure that research technology development programs remain focused on EM`s most pressing remediation and waste management needs. These major problem areas, called Focus Areas are: high-level waste tank remediation; mixed waste characterization, treatment, and disposal; subsurface contaminants; and facility transitioning, decommissioning, and final disposition.

  10. Overview of the Heavy Ion Fusion Program

    CERN Document Server

    Celata, C M

    2000-01-01

    The world Heavy Ion Fusion (HIF) Program for inertial fusion energy is looking toward the development and commissioning of several new experiments. Recent and planned upgrades of the facilities at GSI, in Russia, and in Japan greatly enhance the ability to study energy deposition in hot dense matter. Worldwide target design developments have focused on non-ignition targets for nearterm experiments and designs which, while lowering the energy required for ignition, tighten accelerator requirements. The U.S program is transitioning between scaled beam dynamics experiments and high current experiments with power-plant-driver-scale beams. Current effort is aimed at preparation for the next-step large facility, the Integrated Research Experiment (IRE)-- an induction linac accelerating multiple beams to a few hundred MeV, then focusing to deliver tens of kilojoules to a target. The goal is to study heavy ion energy deposition, and to test all of the components and physics needed for an engineering test of a power p...

  11. Overview of NASA's Microgravity Materials Research Program

    Science.gov (United States)

    Downey, James Patton; Grugel, Richard

    2012-01-01

    The NASA microgravity materials program is dedicated to conducting microgravity experiments and related modeling efforts that will help us understand the processes associated with the formation of materials. This knowledge will help improve ground based industrial production of such materials. The currently funded investigations include research on the distribution of dopants and formation of defects in semiconductors, transitions between columnar and dendritic grain morphology, coarsening of phase boundaries, competition between thermally and kinetically favored phases, and the formation of glassy vs. crystalline material. NASA microgravity materials science investigators are selected for funding either through a proposal in response to a NASA Research Announcement or by participation in a team proposing to a foreign agency research announcement. In the latter case, a US investigator participating in a successful proposal to a foreign agency can then apply to NASA for funding of an unsolicited proposal. The program relies on cooperation with other aerospace partners from around the world. The ISS facilities used for these investigations are provided primarily by partnering with foreign agencies and in most cases the US investigators are working as a part of a larger team studying a specific area of materials science. The following facilities are to be utilized for the initial investigations. The ESA provided Low Gradient Facility and the Solidification and Quench Inserts to the Materials Research Rack/Materials Science Laboratory are to be used primarily for creating bulk samples that are directionally solidified or quenched from a high temperature melt. The CNES provided DECLIC facility is used to observe morphological development in transparent materials. The ESA provided Electro-Magnetic Levitator (EML) is designed to levitate, melt and then cool samples in order to study nucleation behavior. The facility provides conditions in which nucleation of the solid is

  12. Overview of NASA's Microgravity Materials Science Program

    Science.gov (United States)

    Downey, James Patton

    2012-01-01

    The microgravity materials program was nearly eliminated in the middle of the aughts due to budget constraints. Hardware developments were eliminated. Some investigators with experiments that could be performed using ISS partner hardware received continued funding. Partnerships were established between US investigators and ESA science teams for several investigations. ESA conducted peer reviews on the proposals of various science teams as part of an ESA AO process. Assuming he or she was part of a science team that was selected by the ESA process, a US investigator would submit a proposal to NASA for grant funding to support their part of the science team effort. In a similar manner, a US materials investigator (Dr. Rohit Trivedi) is working as a part of a CNES selected science team. As funding began to increase another seven materials investigators were selected in 2010 through an NRA mechanism to perform research related to development of Materials Science Research Rack investigations. One of these has since been converted to a Glovebox investigation.

  13. Overview of the RFX fusion science program

    Science.gov (United States)

    Martin, P.; Adamek, J.; Agostinetti, P.; Agostini, M.; Alfier, A.; Angioni, C.; Antoni, V.; Apolloni, L.; Auriemma, F.; Barana, O.; Barison, S.; Baruzzo, M.; Bettini, P.; Boldrin, M.; Bolzonella, T.; Bonfiglio, D.; Bonomo, F.; Boozer, A. H.; Brombin, M.; Brotankova, J.; Buffa, A.; Canton, A.; Cappello, S.; Carraro, L.; Cavazzana, R.; Cavinato, M.; Chacon, L.; Chitarin, G.; Cooper, W. A.; Dal Bello, S.; Dalla Palma, M.; Delogu, R.; De Lorenzi, A.; De Masi, G.; Dong, J. Q.; Drevlak, M.; Escande, D. F.; Fantini, F.; Fassina, A.; Fellin, F.; Ferro, A.; Fiameni, S.; Fiorentin, A.; Franz, P.; Gaio, E.; Garbet, X.; Gazza, E.; Giudicotti, L.; Gnesotto, F.; Gobbin, M.; Grando, L.; Guo, S. C.; Hirano, Y.; Hirshman, S. P.; Ide, S.; Igochine, V.; In, Y.; Innocente, P.; Kiyama, S.; Liu, S. F.; Liu, Y. Q.; Lòpez Bruna, D.; Lorenzini, R.; Luchetta, A.; Manduchi, G.; Mansfield, D. K.; Marchiori, G.; Marcuzzi, D.; Marrelli, L.; Martini, S.; Matsunaga, G.; Martines, E.; Mazzitelli, G.; McCollam, K.; Menmuir, S.; Milani, F.; Momo, B.; Moresco, M.; Munaretto, S.; Novello, L.; Okabayashi, M.; Ortolani, S.; Paccagnella, R.; Pasqualotto, R.; Pavei, M.; Perverezev, G. V.; Peruzzo, S.; Piovan, R.; Piovesan, P.; Piron, L.; Pizzimenti, A.; Pomaro, N.; Pomphrey, N.; Predebon, I.; Puiatti, M. E.; Rigato, V.; Rizzolo, A.; Rostagni, G.; Rubinacci, G.; Ruzzon, A.; Sakakita, H.; Sanchez, R.; Sarff, J. S.; Sattin, F.; Scaggion, A.; Scarin, P.; Schneider, W.; Serianni, G.; Sonato, P.; Spada, E.; Soppelsa, A.; Spagnolo, S.; Spolaore, M.; Spong, D. A.; Spizzo, G.; Takechi, M.; Taliercio, C.; Terranova, D.; Toigo, V.; Valisa, M.; Veranda, M.; Vianello, N.; Villone, F.; Wang, Z.; White, R. B.; Yadikin, D.; Zaccaria, P.; Zamengo, A.; Zanca, P.; Zaniol, B.; Zanotto, L.; Zilli, E.; Zollino, G.; Zuin, M.

    2011-09-01

    This paper summarizes the main achievements of the RFX fusion science program in the period between the 2008 and 2010 IAEA Fusion Energy Conferences. RFX-mod is the largest reversed field pinch in the world, equipped with a system of 192 coils for active control of MHD stability. The discovery and understanding of helical states with electron internal transport barriers and core electron temperature >1.5 keV significantly advances the perspectives of the configuration. Optimized experiments with plasma current up to 1.8 MA have been realized, confirming positive scaling. The first evidence of edge transport barriers is presented. Progress has been made also in the control of first-wall properties and of density profiles, with initial first-wall lithization experiments. Micro-turbulence mechanisms such as ion temperature gradient and micro-tearing are discussed in the framework of understanding gradient-driven transport in low magnetic chaos helical regimes. Both tearing mode and resistive wall mode active control have been optimized and experimental data have been used to benchmark numerical codes. The RFX programme also provides important results for the fusion community and in particular for tokamaks and stellarators on feedback control of MHD stability and on three-dimensional physics. On the latter topic, the result of the application of stellarator codes to describe three-dimensional reversed field pinch physics will be presented.

  14. Mars Exploration Rover thermal test program overview

    Science.gov (United States)

    Pauken, Michael T.; Kinsella, Gary; Novak, Keith; Tsuyuki, Glenn

    2004-01-01

    In January 2004, two Mars Exploration Rovers (MER) landed on the surface of Mars to begin their mission as robotic geologists. A year prior to these historic landings, both rovers and the spacecraft that delivered them to Mars, were completing a series of environmental tests in facilities at the Jet Propulsion Laboratory. This paper describes the test program undertaken to validate the thermal design and verify the workmanship integrity of both rovers and the spacecraft. The spacecraft, which contained the rover within the aeroshell, were tested in a 7.5 m diameter thermal vacuum chamber. Thermal balance was performed for the near earth (hot case) condition and for the near Mars (cold case) condition. A solar simulator was used to provide the solar boundary condition on the solar array. IR lamps were used to simulate the solar heat load on the aeroshell for the off-sun attitudes experienced by the spacecraft during its cruise to Mars. Each rover was tested separately in a 3.0 m diameter thermal vacuum chamber over conditions simulating the warmest and coldest expected Mars diurnal temperature cycles. The environmental tests were conducted in a quiescent nitrogen atmosphere at a pressure of 8 to 10 Torr. In addition to thermal balance testing, the science instruments on board the rovers were tested successfully in the extreme environmental conditions anticipated for the mission. A solar simulator was not used in these tests.

  15. Overview of the Defense Programs Research and Technology Development Program for Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This documents presents a programmatic overview and program element plan summaries for conceptual design and assessment; physics; computation and modeling; system engineering science and technology; electronics, photonics, sensors, and mechanical components; chemistry and materials; special nuclear materials, tritium, and explosives.

  16. Los Alamos safeguards program overview and NDA in safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Keepin, G.R.

    1988-01-01

    Over the years the Los Alamos safeguards program has developed, tested, and implemented a broad range of passive and active nondestructive analysis (NDA) instruments (based on gamma and x-ray detection and neutron counting) that are now widely employed in safeguarding nuclear materials of all forms. Here very briefly, the major categories of gamma ray and neutron based NDA techniques, give some representative examples of NDA instruments currently in use, and cite a few notable instances of state-of-the-art NDA technique development. Historical aspects and a broad overview of the safeguards program are also presented.

  17. Refractive index of K9 Glass under Shock Loading

    Science.gov (United States)

    Hu, Changming; Wang, Xiang; Cai, Lingcang; Liu, Cangli

    2013-06-01

    We study K9 glass refraction index under shock loading conducted on powder gun,all experimental tests are plate impact loading. The impact veceloty range from 300m/s to 1200m/s, and the measure method is laser interferometer Photon Doppler Velocimetry(PDV) to measure the particle velocity both at the impact interface and free surface, The shock pressure from 2 GPa to 8 GPa, values for refraction are found from velocity corrections that must be made to account for refraction-index changes in the K9 glass due to shock wave motion. Experiment results show that refraction-index of K9 glass changes with the shock pressure in line relations, it can be as measure window to study the interesting materials under 10 GPa during the shock loading.

  18. 起亚全新车型K9

    Institute of Scientific and Technical Information of China (English)

    肖昕

    2012-01-01

    车型平台源自雅科仕。外观造型出自大师手笔一如K2与瑞纳、K5与索纳塔的兄弟关系,K9也自然而然地继承了雅科仕的车型平台。不过出自设计大师彼得·希瑞尔手笔的K9显然不像保守的雅科仕那么死气沉沉,

  19. Overview of the Lockheed Martin Compact Fusion Reactor (CFR) Program

    Science.gov (United States)

    McGuire, Thomas

    2015-11-01

    The Lockheed Martin Compact Fusion Reactor (CFR) Program endeavors to quickly develop a compact fusion power plant with favorable commercial economics and military utility. An overview of the concept and its diamagnetic, high beta magnetically encapsulated linear ring cusp confinement scheme will be given. The analytical model of the major loss mechanisms and predicted performance will be discussed, along with the major physics challenges. Key features of an operational CFR reactor will be highlighted. The proposed developmental path following the current experimental efforts will be presented. ©2015 Lockheed Martin Corporation. All Rights Reserved.

  20. 76 FR 5789 - Teaching American History Grant Program; Office of Innovation and Improvement; Overview...

    Science.gov (United States)

    2011-02-02

    ... Teaching American History Grant Program; Office of Innovation and Improvement; Overview Information; Teaching American History Grant Program; Notice Inviting Applications for New Awards for Fiscal Year (FY... of Announcement I. Funding Opportunity Description Purpose of Program: The Teaching American History...

  1. K9与空警协同作战

    Institute of Scientific and Technical Information of China (English)

    李钢; 游海霞

    2011-01-01

    在美国、俄罗斯等国,用"K9"指代警犬和军犬.这个称呼始于第二次世界大战.当时,美国看到第一次世界大战期间军犬在战场上发挥的巨大作用,于是也开始组建自己的拥有2万只军犬的特种部队,用于执行侦察、放哨、探测地雷、警卫等军事任务.但是,如何给这支部队编号呢?于是就有人想到犬的英文单词Canine的谐音K9.这个编号深受官方和公众的欢迎,很快就风靡开来.

  2. The K9 On-Board Rover Architecture

    Science.gov (United States)

    Bresina, John L.; Bualat, Maria; Fair, Michael; Washington, Richard; Wright, Anne

    2006-01-01

    This paper describes the software architecture of NASA Ames Research Center s K9 rover. The goal of the onboard software architecture team was to develop a modular, flexible framework that would allow both high- and low-level control of the K9 hardware. Examples of low-level control are the simple drive or pan/tilt commands which are handled by the resource managers, and examples of high-level control are the command sequences which are handled by the conditional executive. In between these two control levels are complex behavioral commands which are handled by the pilot, such as drive to goal with obstacle avoidance or visually servo to a target. This paper presents the design of the architecture as of Fall 2000. We describe the state of the architecture implementation as well as its current evolution. An early version of the architecture was used for K9 operations during a dual-rover field experiment conducted by NASA Ames Research Center (ARC) and the Jet Propulsion Laboratory (JPL) from May 14 to May 16, 2000.

  3. U.S. DOE indirect coal liquefaction program: An overview

    Energy Technology Data Exchange (ETDEWEB)

    Shen, J.; Schmetz, E.; Winslow, J.; Tischer, R. [Dept. of Energy, Germantown, MD (United States); Srivastava, R.

    1997-12-31

    Coal is the most abundant domestic energy resource in the United States. The Fossil Energy Organization within the US Department of Energy (DOE) has been supporting a coal liquefaction program to develop improved technologies to convert coal to clean and cost-effective liquid fuels to complement the dwindling supply of domestic petroleum crude. The goal of this program is to produce coal liquids that are competitive with crude at $20 to $25 per barrel. Indirect and direct liquefaction routes are the two technologies being pursued under the DOE coal liquefaction program. This paper will give an overview of the DOE indirect liquefaction program. More detailed discussions will be given to the F-T diesel and DME fuels which have shown great promises as clean burning alternative diesel fuels. The authors also will briefly discuss the economics of indirect liquefaction and the hurdles and opportunities for the early commercial deployment of these technologies. Discussions will be preceded by two brief reviews on the liquid versus gas phase reactors and the natural gas versus coal based indirect liquefaction.

  4. H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.

    Science.gov (United States)

    Kuang, Fei Li; Luo, Zhonghui; Scharff, Matthew D

    2009-03-31

    Class switch recombination (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that allows the same variable (V) region to be expressed with any one of the downstream constant region (C) genes to encode antibodies with many different effector functions. One hypothesis for how CSR is targeted to different C region genes is that histone modifications increase accessibility and/or recruit activation-induced cytosine deaminase (AID) and its associated processes to particular donor and recipient switch regions. In this work, we identified H3 acetyl K9 and H3 trimethyl K9 as histone modifications that correlate with the recombining pair of donor and recipient switch regions. The appearance of H3 trimethyl K9 is surprising because usually it is thought to mark silent genes and heterochromatin. Nevertheless, the time course of appearance of these histone modifications, the regions in IgH they associate with, and their appearance independent of AID damage suggest that both modifications play a role in targeting CSR.

  5. The NASA Electronic Parts and Packaging (NEPP) Program: An Overview

    Science.gov (United States)

    Label, Kenneth A.; Sampson, Michael J.

    2016-01-01

    This presentation provides an overview of the NEPP Program. The NEPP Mission is to provide guidance to NASA for the selection and application of microelectronics technologies; Improve understanding of the risks related to the use of these technologies in the space environment; Ensure that appropriate research is performed to meet NASA mission assurance needs. NEPP's Goals are to provide customers with appropriate and cost-effective risk knowledge to aid in: Selection and application of microelectronics technologies; Improved understanding of risks related to the use of these technologies in the space environment; Appropriate evaluations to meet NASA mission assurance needs; Guidelines for test and application of parts technologies in space; Assurance infrastructure and support for technologies in use by NASA space systems.

  6. Overview of the NRL DPF program: Experiment and Modeling

    Science.gov (United States)

    Richardson, A. S.; Jackson, S. L.; Angus, J. R.; Giuliani, J. L.; Swanekamp, S. B.; Schumer, J. W.; Mosher, D.

    2016-10-01

    Charged particle acceleration in imploding plasmas is an important phenomenon which occurs in various natural and laboratory plasmas. A new research project at the Naval Research Laboratory (NRL) has been started to investigate this phenomenon both experimentally-in a dense plasma focus (DPF) device-and theoretically using analytical and computational modeling. The DPF will be driven by the high-inductance (607 nH) Hawk pulsed-power generator, with a rise time of 1.2 μs and a peak current of 665 kA. In this poster we present an overview of the research project, and some preliminary results from fluid simulations of the m = 0 instability in an idealized DPF pinch. This work was supported by the Naval Research Laboratory Base Program.

  7. Physics of the Cosmos (PCOS) Technology Development Program Overview

    Science.gov (United States)

    Pham, B. Thai; Clampin, M.; Werneth, R. L.

    2014-01-01

    The Physics of the Cosmos (PCOS) Program Office was established in FY11 and resides at the NASA Goddard Space Flight Center (GSFC). The office serves as the implementation arm for the Astrophysics Division at NASA Headquarters for PCOS Program related matters. We present an overview of the Program’s technology management activities and the Program’s technology development portfolio. We discuss the process for addressing community-provided technology needs and the Technology Management Board (TMB)-vetted prioritization and investment recommendations. This process improves the transparency and relevance of technology investments, provides the community a voice in the process, and leverages the technology investments of external organizations by defining a need and a customer. Goals for the PCOS Program envisioned by the National Research Council’s (NRC) “New Worlds, New Horizons in Astronomy and Astrophysics” (NWNH) Decadal Survey report include science missions and technology development for dark energy, gravitational waves, X-ray, and inflation probe science.

  8. Main: 1K9B [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1K9B 大豆 Soybean Glycine max (L.) Merrill Bowman-Birk Type Proteinase Inhibitor Precursor Glycine Ma...x Molecule: Bowman-Birk Type Proteinase Inhibitor; Chain: A; Synonym: Bbi; Other_details: Fr....O.Essen, G.Wenzl, Y.M.Kim, P.Flecker Crystal Structure Of The Bifunctional Soybean Bowma...n-Birk Inhibitor At 0.28 Nm Resolution. Structural Peculiarities In A Folded Protein Conformation Eu...877; Prot_inh_BBI.|Pfam; PF00228; Bowman-Birk_leg; 2.|SMART; SM00269; BowB; 1.|PROSITE; PS00281; BOWMAN_BIRK

  9. An overview of solution methods for multi-objective mixed integer linear programming programs

    DEFF Research Database (Denmark)

    Andersen, Kim Allan; Stidsen, Thomas Riis

    Multiple objective mixed integer linear programming (MOMIP) problems are notoriously hard to solve to optimality, i.e. finding the complete set of non-dominated solutions. We will give an overview of existing methods. Among those are interactive methods, the two phases method and enumeration...... methods. In particular we will discuss the existing branch and bound approaches for solving multiple objective integer programming problems. Despite the fact that branch and bound methods has been applied successfully to integer programming problems with one criterion only a few attempts has been made...

  10. An overview of solution methods for multi-objective mixed integer linear programming programs

    DEFF Research Database (Denmark)

    Andersen, Kim Allan; Stidsen, Thomas Riis

    Multiple objective mixed integer linear programming (MOMIP) problems are notoriously hard to solve to optimality, i.e. finding the complete set of non-dominated solutions. We will give an overview of existing methods. Among those are interactive methods, the two phases method and enumeration...... methods. In particular we will discuss the existing branch and bound approaches for solving multiple objective integer programming problems. Despite the fact that branch and bound methods has been applied successfully to integer programming problems with one criterion only a few attempts has been made...

  11. Structural biology of human H3K9 methyltransferases.

    Directory of Open Access Journals (Sweden)

    Hong Wu

    Full Text Available UNLABELLED: SET domain methyltransferases deposit methyl marks on specific histone tail lysine residues and play a major role in epigenetic regulation of gene transcription. We solved the structures of the catalytic domains of GLP, G9a, Suv39H2 and PRDM2, four of the eight known human H3K9 methyltransferases in their apo conformation or in complex with the methyl donating cofactor, and peptide substrates. We analyzed the structural determinants for methylation state specificity, and designed a G9a mutant able to tri-methylate H3K9. We show that the I-SET domain acts as a rigid docking platform, while induced-fit of the Post-SET domain is necessary to achieve a catalytically competent conformation. We also propose a model where long-range electrostatics bring enzyme and histone substrate together, while the presence of an arginine upstream of the target lysine is critical for binding and specificity. ENHANCED VERSION: This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1.

  12. Data of evolutionary structure change: 1K9PA-1CNPA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1K9PA-1CNPA 1K9P 1CNP A A -ACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQ...D>1K9P A 1K9PA IGSKL-QDAEI 1CNP A 1CNPA VAL CA 413 -13.432999610900879 15.65699958801269...5 50.41999816894531 rallel> 0.11400000005960464 0.9580000042915344 <

  13. Brazilian Air Force aircraft structural integrity program: An overview

    Directory of Open Access Journals (Sweden)

    Alberto W. S. Mello Junior

    2009-01-01

    Full Text Available This paper presents an overview of the activities developed by the Structural Integrity Group at the Institute of Aeronautics and Space - IAE, Brazil, as well as the status of ongoing work related to the life extension program for aircraft operated by the Brazilian Air Force BAF. The first BAF-operated airplane to undergo a DTA-based life extension was the F-5 fighter, in the mid 1990s. From 1998 to 2001, BAF worked on a life extension project for the BAF AT- 26 Xavante trainer. All analysis and tests were performed at IAE. The fatigue critical locations (FCLs were presumed based upon structural design and maintenance data and also from exchange of technical information with other users of the airplane around the world. Following that work, BAF started in 2002 the extension of the operational life of the BAF T-25 “Universal”. The T-25 is the basic training airplane used by AFA - The Brazilian Air Force Academy. This airplane was also designed under the “safe-life” concept. As the T-25 fleet approached its service life limit, the Brazilian Air Force was questioning whether it could be kept in flight safely. The answer came through an extensive Damage Tolerance Analysis (DTA program, briefly described in this paper. The current work on aircraft structural integrity is being performed for the BAF F-5 E/F that underwent an avionics and weapons system upgrade. Along with the increase in weight, new configurations and mission profiles were established. Again, a DTA program was proposed to be carried out in order to establish the reliability of the upgraded F-5 fleet. As a result of all the work described, the BAF has not reported any accident due to structural failure on aircraft submitted to Damage Tolerance Analysis.

  14. Overview of Mars Science Laboratory (MSL) Environmental Program

    Science.gov (United States)

    Forgave, John C.; Man, Kin F.; Hoffman, Alan R.

    2006-01-01

    This viewgraph presentation is an overview of the Mars Science Laboratory (MSL) program. The engineering objectives of the program are to create a Mobile Science Laboratory capable of one Mars Year surface operational lifetime (670 Martian sols = 687 Earth days). It will be able to land and operation over wide range of latitudes, altitudes and seasons It must have controlled propulsive landing and demonstrate improved landing precision via guided entry The general science objectives are to perform science that will focus on Mars habitability, perform next generation analytical laboratory science investigations, perform remote sensing/contact investigations and carry a suite of environmental monitoring instruments. Specific scientific objectives of the MSL are: (1) Characterization of geological features, contributing to deciphering geological history and the processes that have modified rocks and regolith, including the role of water. (2) Determination of the mineralogy and chemical composition (including an inventory of elements such as C, H, N, O, P, S, etc. known to be building blocks for life) of surface and near-surface materials. (3) Determination of energy sources that could be used to sustain biological processes. (4) Characterization of organic compounds and potential biomarkers in representative regolith, rocks, and ices. (5) Determination the stable isotopic and noble gas composition of the present-day bulk atmosphere. (6) Identification potential bio-signatures (chemical, textural, isotopic) in rocks and regolith. (7) Characterization of the broad spectrum of surface radiation, including galactic cosmic radiation, solar proton events, and secondary neutrons. (8) Characterization of the local environment, including basic meteorology, the state and cycling of water and C02, and the near-surface distribution of hydrogen. Several views of the planned MSL and the rover are shown. The MSL environmental program is to: (1) Ensure the flight hardware design is

  15. Architecture for Control of the K9 Rover

    Science.gov (United States)

    Bresina, John L.; Bualat, maria; Fair, Michael; Wright, Anne; Washington, Richard

    2006-01-01

    Software featuring a multilevel architecture is used to control the hardware on the K9 Rover, which is a mobile robot used in research on robots for scientific exploration and autonomous operation in general. The software consists of five types of modules: Device Drivers - These modules, at the lowest level of the architecture, directly control motors, cameras, data buses, and other hardware devices. Resource Managers - Each of these modules controls several device drivers. Resource managers can be commanded by either a remote operator or the pilot or conditional-executive modules described below. Behaviors and Data Processors - These modules perform computations for such functions as planning paths, avoiding obstacles, visual tracking, and stereoscopy. These modules can be commanded only by the pilot. Pilot - The pilot receives a possibly complex command from the remote operator or the conditional executive, then decomposes the command into (1) more-specific commands to the resource managers and (2) requests for information from the behaviors and data processors. Conditional Executive - This highest-level module interprets a command plan sent by the remote operator, determines whether resources required for execution of the plan are available, monitors execution, and, if necessary, selects an alternate branch of the plan.

  16. An Overview of Fifth-Year Teacher Education Programs.

    Science.gov (United States)

    Helmich, Edith

    A series of model five-year teacher education programs are described. Two main types of programs are included--state-initiated programs and university-based fifth-year programs. An analysis and description of of the following programs is presented: (1) Florida Performance Program Management System--Beginning Teacher Program; (2) Kentucky…

  17. An Overview of the Evidence on Bullying Prevention and Intervention Programs

    National Research Council Canada - National Science Library

    Mishna, Faye

    2008-01-01

    ... of experiencing problems that may persist into adulthood. The aim of this article is to provide a brief overview of key points and issues regarding the current state of anti-bullying prevention and intervention programs...

  18. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability

    Science.gov (United States)

    Liu, Nan; Zhang, Zhuqiang; Jiang, Yonghua; Meng, Lingjun; Xiong, Jun; Zhao, Zuodong; Zhou, Xiaohua; Li, Jia; Li, Hong; Zheng, Yong; Chen, She; Cai, Tao; Gao, Shaorong

    2015-01-01

    GLP and G9a are major H3K9 dimethylases and are essential for mouse early embryonic development. GLP and G9a both harbor ankyrin repeat domains that are capable of binding H3K9 methylation. However, the functional significance of their recognition of H3K9 methylation is unknown. Here, we report that the histone methyltransferase activities of GLP and G9a are stimulated by neighboring nucleosomes that are premethylated at H3K9. These stimulation events function in cis and are dependent on the H3K9 methylation binding activities of ankyrin repeat domains of GLP and G9a. Disruption of the H3K9 methylation-binding activity of GLP in mice causes growth retardation of embryos, ossification defects of calvaria, and postnatal lethality due to starvation of the pups. In mouse embryonic stem cells (ESCs) harboring a mutant GLP that lacks H3K9me1-binding activity, critical pluripotent genes, including Oct4 and Nanog, display inefficient establishment of H3K9me2 and delayed gene silencing during differentiation. Collectively, our study reveals a new activation mechanism for GLP and G9a that plays an important role in ESC differentiation and mouse viability. PMID:25637356

  19. An Overview of Quality Programs that Support Transition-Aged Youth

    Directory of Open Access Journals (Sweden)

    Christopher M. Kalinyak

    2016-12-01

    Full Text Available This article provides a concise overview of several programs that deliver services to transition-aged youth, ages 14–29. Included are family support, the Assisting Unaccompanied Children and Youth program, the Substance Abuse and Mental Health Services Administration services, the wraparound approach, intensive home-based treatment, multisystemic therapy, foster care, independent living, mentoring, the Steps to Success program, the Jump on Board for Success program, the Options program, the Positive Action program, the Transition to Success model, and the Transition to Independence Program. Primary focus is placed upon the usefulness of each of the programs in facilitating successful outcomes for transition-aged youth.

  20. Overview of an Advanced Hypersonic Structural Concept Test Program

    Science.gov (United States)

    Stephens, Craig A.; Hudson, Larry D.; Piazza, Anthony

    2007-01-01

    This viewgraph presentation provides an overview of hypersonics M&S advanced structural concepts development and experimental methods. The discussion on concepts development includes the background, task objectives, test plan, and current status of the C/SiC Ruddervator Subcomponent Test Article (RSTA). The discussion of experimental methods examines instrumentation needs, sensors of interest, and examples of ongoing efforts in the development of extreme environment sensors.

  1. The NASA Electronic Parts and Packaging (NEPP) Program: Overview and Update FY15 and Beyond

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2016-01-01

    The NASA Electronic Parts and Packaging (NEPP) program, and its subset the NASA Electronic Parts Assurance Group (NEPAG), are NASA's point-of-contacts for reliability and radiation tolerance of electrical, electronic, and electromechanical (EEE) parts and their packages. This presentation includes a Fiscal Year 2015 program overview.

  2. Encendiendo una Llama. Bilingual Gifted and Talented Program: Overview, Identification of Students, and Instructional Approaches.

    Science.gov (United States)

    Hartford Public Schools, CT.

    Three pamphlets describe facets of "Encendiendo Una Llama," a Hartford (Connecticut) demonstration program for bilingual gifted and talented students. An overview pamphlet summarizes key aspects of the model program: identification procedures, instructional services, teacher training, parent involvement, evidence of effectiveness, implementation…

  3. Human Research Program Science Management: Overview of Research and Development Activities

    Science.gov (United States)

    Charles, John B.

    2007-01-01

    An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

  4. Overview of the U.S. Department of Energy's Isotope Programs

    Energy Technology Data Exchange (ETDEWEB)

    Carty, J.

    2004-10-05

    This presentation provides an overview of the U.S. Department of Energy's Isotopes Program. The charter of the Isotope Programs covers the production and sale of radioactive and stable isotopes, associated byproducts, surplus materials, and related isotope services.

  5. 76 FR 14379 - Advanced Placement Incentive Program; Office of Elementary and Secondary Education; Overview...

    Science.gov (United States)

    2011-03-16

    ... Advanced Placement Incentive Program; Office of Elementary and Secondary Education; Overview Information... Advanced Placement Programs is from section 1705(c) of the Elementary and Secondary Education Act of 1965... Secondary Education may change the maximum amount through a notice published in the Federal...

  6. SHPPS 2006: School Health Policies and Programs Study--Overview

    Science.gov (United States)

    Centers for Disease Control and Prevention, 2007

    2007-01-01

    The School Health Policies and Programs Study (SHPPS) is a national survey periodically conducted to assess school health policies and programs at the state, district, school, and classroom levels. SHPPS 2006 was designed to answer the following questions: (1) What are the characteristics of each school health program component at the state,…

  7. The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Silje V Veiseth

    2011-03-01

    Full Text Available Chromatin structure and gene expression are regulated by posttranslational modifications (PTMs on the N-terminal tails of histones. Mono-, di-, or trimethylation of lysine residues by histone lysine methyltransferases (HKMTases can have activating or repressive functions depending on the position and context of the modified lysine. In Arabidopsis, trimethylation of lysine 9 on histone H3 (H3K9me3 is mainly associated with euchromatin and transcribed genes, although low levels of this mark are also detected at transposons and repeat sequences. Besides the evolutionarily conserved SET domain which is responsible for enzyme activity, most HKMTases also contain additional domains which enable them to respond to other PTMs or cellular signals. Here we show that the N-terminal WIYLD domain of the Arabidopsis SUVR4 HKMTase binds ubiquitin and that the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin, enabling conversion of H3K9me1 to H3K9me3 in vitro. Chromatin immunoprecipitation and immunocytological analysis showed that SUVR4 in vivo specifically converts H3K9me1 to H3K9me3 at transposons and pseudogenes and has a locus-specific repressive effect on the expression of such elements. Bisulfite sequencing indicates that this repression involves both DNA methylation-dependent and -independent mechanisms. Transcribed genes with high endogenous levels of H3K4me3, H3K9me3, and H2Bub1, but low H3K9me1, are generally unaffected by SUVR4 activity. Our results imply that SUVR4 is involved in the epigenetic defense mechanism by trimethylating H3K9 to suppress potentially harmful transposon activity.

  8. NASA’S PLANETARY GEOLOGIC MAPPING PROGRAM: OVERVIEW

    OpenAIRE

    Williams, D. A.

    2016-01-01

    NASA’s Planetary Science Division supports the geologic mapping of planetary surfaces through a distinct organizational structure and a series of research and analysis (R&A) funding programs. Cartography and geologic mapping issues for NASA’s planetary science programs are overseen by the Mapping and Planetary Spatial Infrastructure Team (MAPSIT), which is an assessment group for cartography similar to the Mars Exploration Program Assessment Group (MEPAG) for Mars exploration. MAPSIT...

  9. (abstract) JPL Cryocooler Development and Test Program Overview

    Science.gov (United States)

    Ross, R. G.

    1994-01-01

    Many near-term and future space-instrument programs within NASA and the Ballistic Missile Defense Organization (BMDO) depend on the successful development of long-life, low-vibration space cryocoolers. The most demanding near-term programs include a number of science instruments selected for NASA's Earth Observing System (Eos) program, and a number of space reconnaissance instruments associated with the BMDO's Brilliant Eyes program; both of these programs require delivery of similar types of flight coolers in the next few years. To help ensure the success of these cooler commitments, JPL has implemented an extensive cryocooler program in support of the NASA/JPL AIRS project, the Air Force Phillips Laboratory (AFPL), and the Air Force Space and Missiles Systems Division (SMC). This program is directed at assisting industry in developing advanced cryocoolers that successfully address the broad array of complex performance requirements needed for NASA and BMDO long-life space instruments. The JPL cryocooler program includes extensive characterization and life testing of industry-developed cryocoolers, development and flight testing of advanced sorption cooler systems for detector cooling to 10 K , development of mechanical cryocooler enhancement technologies, and flight tests of advanced low-vibration Stirling-cooler systems.

  10. Lawrence Berkeley Laboratory/University of California lighting program overview

    Energy Technology Data Exchange (ETDEWEB)

    Berman, S.

    1981-12-01

    The objective of the Lighting Program is to assist and work in concert with the lighting community (composed of manufacturers, designers, and users) to achieve a more efficient lighting economy. To implement its objectives, the Lighting Program has been divided into three major categories: technical engineering, buildings applications, and human impacts (impacts on health and vision). The technical program aims to undertake research and development projects that are both long-range and high-risk and which the lighting industry has little interest in pursuing on its own, but from which significant benefits could accrue to both the public and the industry. The building applications program studies the effects that introducing daylighting in commercial buildings has on lighting and cooling electrical energy requirements as well as on peak demand. This program also examines optimization strategies for integrating energy-efficient design, lighting hardware, daylighting, and overall building energy requirements. The impacts program examines relationships between the user and the physical lighting environment, in particular how new energy-efficient technologies relate to human productivity and health. These efforts are interdisciplinary, involving engineering, optometry, and medicine. The program facilities are described and the personnel in the program is identified.

  11. Overview of Four Prescription Monitoring/Review Programs in Canada

    Directory of Open Access Journals (Sweden)

    Andrea D Furlan

    2014-01-01

    Full Text Available BACKGROUND: Prescription monitoring or review programs collect information about prescription and dispensing of controlled substances for the purposes of monitoring, analysis and education. In Canada, it is the responsibility of the provincial institutions to organize, maintain and run such programs.

  12. Overview and Summary: School Health Policies and Programs Study 2006

    Science.gov (United States)

    Kann, Laura; Brener, Nancy D.; Wechsler, Howell

    2007-01-01

    Background: The School Health Policies and Programs Study (SHPPS) 2006 is the largest, most comprehensive assessment of school health programs in the United States ever conducted. Methods: The Centers for Disease Control and Prevention conducts SHPPS every 6 years. In 2006, computer-assisted telephone interviews or self-administered mail…

  13. Marshall Island radioassay quality assurance program an overview

    Energy Technology Data Exchange (ETDEWEB)

    Conrado, C.L.; Hamilton, T.F.; Kehl, S.R.; Robison, W.L.; Stoker, A.C.

    1998-09-01

    The Lawrence Livermore National Laboratory has developed an extensive quality assurance program to provide high quality data and assessments in support of the Marshall Islands Dose Assessment and Radioecology Program. Our quality assurance objectives begin with the premise of providing integrated and cost-effective program support (to meet wide-ranging programmatic needs, scientific peer review, litigation defense, and build public confidence) and continue through from design and implementation of large-scale field programs, sampling and sample preparation, radiometric and chemical analyses, documentation of quality assurance/quality control practices, exposure assessments, and dose/risk assessments until publication. The basic structure of our radioassay quality assurance/quality control program can be divided into four essential elements; (1) sample and data integrity control; (2) instrument validation and calibration; (3) method performance testing, validation, development and documentation; and (4) periodic peer review and on-site assessments. While our quality assurance objectives are tailored towards a single research program and the evaluation of major exposure pathways/critical radionuclides pertinent to the Marshall Islands, we have attempted to develop quality assurance practices that are consistent with proposed criteria designed for laboratory accre

  14. NASA RPS Program Overview: A Focus on RPS Users

    Science.gov (United States)

    Hamley, John A.; Sutliff, Thomas J.; Sandifer, Carl E., II; Zakrajsek, June F.

    2016-01-01

    The goal of NASA's Radioisotope Power Systems (RPS) Program is to make RPS ready and available to support the exploration of the solar system in environments where the use of conventional solar or chemical power generation is impractical or impossible to meet the needs of the missions. To meet this goal, the RPS Program, working closely with the Department of Energy, performs mission and system studies (such as the recently released Nuclear Power Assessment Study), assesses the readiness of promising technologies to infuse in future generators, assesses the sustainment of key RPS capabilities and knowledge, forecasts and tracks the Programs budgetary needs, and disseminates current information about RPS to the community of potential users. This process has been refined and used to determine the current content of the RPS Programs portfolio. This portfolio currently includes an effort to mature advanced thermoelectric technology for possible integration into an enhanced Multi-Mission Radioisotope Generator (eMMRTG), sustainment and production of the currently deployed MMRTG, and technology investments that could lead to a future Stirling Radioisotope Generator (SRG). This paper describes the program planning processes that have been used, the currently available MMRTG, and one of the potential future systems, the eMMRTG.

  15. Overview of the solar dynamic ground test demonstration program

    Science.gov (United States)

    Shaltens, Richard K.; Boyle, Robert V.

    1993-01-01

    The Solar Dynamic (SD) Ground Test Demonstration (GTD) program demonstrates the availability of SD technologies in a simulated space environment at the NASA Lewis Research Center (LeRC) vacuum facility. An aerospace industry/ government team is working together to design, fabricate, build, and test a complete SD system. This paper reviews the goals and status of the SD GTD program. A description of the SD system includes key design features of the system, subsystems, and components as reported at the Critical Design Review (CDR).

  16. Overview of the EPA quality system for environmental programs

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, G.L. [Environmental Protection Agency, Research Triangle Park, NC (United States)

    1993-12-31

    Formalized quality assurance program requirements for the U.S. Environmental Protection Agency (EPA) have been established for more than a decade. During this period, the environmental issues and concerns addressed by the EPA have changed. Many issues, such as ozone depletion and global climate warming, have become international concerns among the world environmental community. Other issues, such as hazardous waste cleanup and clean air, remain a focus of national environmental concerns. As the environmental issues of the 1980`s evolved, the traditional quality assurance (QA) program was transformed through the use of quality management principles into a Quality System to help managers meet the needs of the 1990`s and beyond.

  17. High-level waste immobilization program: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Bonner, W.R.

    1979-09-01

    The High-Level Waste Immobilization Program is providing technology to allow safe, affordable immobilization and disposal of nuclear waste. Waste forms and processes are being developed on a schedule consistent with national needs for immobilization of high-level wastes stored at Savannah River, Hanford, Idaho National Engineering Laboratory, and West Valley, New York. This technology is directly applicable to high-level wastes from potential reprocessing of spent nuclear fuel. The program is removing one more obstacle previously seen as a potential restriction on the use and further development of nuclear power, and is thus meeting a critical technological need within the national objective of energy independence.

  18. Dangerous R loops form in the absence of H3K9 methylation

    DEFF Research Database (Denmark)

    Salcini, Anna Elisabetta

    2016-01-01

    Methylation of histone H3 on lysine 9 (H3K9) is a hallmark of transcriptionally inactive heterochromatin that is deregulated in pathological conditions. A new study shows that complete loss of H3K9 methylation in Caenorhabditis elegans leads to derepression of repetitive elements and formation...

  19. Geometric Modeling Applications Interface Program (GMAP). Volume 1. Executive Overview

    Science.gov (United States)

    1989-09-01

    Z . Code) 10. SOURCE OF FUNDING NOS. PROGRAM PROJECT TASK WORK UNIT ELEMENT NO. NO. NO. NO. 11. TITLE (Include Security Classification) GEOMETRIC...342f CI FTR560240OOlU September 1989 SECTION 2 SCOPE OF GMAP GMAP focused on the generacion , control, and exchange of computer information to replace

  20. Biomass Power: Program overview fiscal years 1993--1994

    Science.gov (United States)

    1995-03-01

    The Biomass Power Program and industry are developing technologies to expand the use of biomass that include methods of feedstock production and the equipment to convert feedstocks into electric power or process heat. With the help of advanced biomass power technologies and new feedstock supply systems, as much as 50,000 megawatts (MW) of biomass power capacity will be in place by the year 2010. The Biomass Power Program supports the development of three technologies -- gasification, pyrolysis, and direct combustion -- from the laboratory bench scale to the prototype commercial scale. Gasification equipment produces biogas that is burned in high-efficiency turbine-generators developed for the electric power industry. Pyrolysis processes produce oils from renewable biomass that burn like petroleum to generate electricity. In direct combustion technology, power plants today burn bulk biomass directly to generate electricity. Improving the direct combustion technology of these plants increases efficiency and reduces emissions. In addition to developing these three technologies, the Biomass Power Program supports joint ventures to plan and construct facilities that demonstrate the benefits of biomass power. The program is supporting joint ventures to conduct 10 case studies of dedicated feedstock supply systems.

  1. Computing, Information, and Communications Technology (CICT) Program Overview

    Science.gov (United States)

    VanDalsem, William R.

    2003-01-01

    The Computing, Information and Communications Technology (CICT) Program's goal is to enable NASA's Scientific Research, Space Exploration, and Aerospace Technology Missions with greater mission assurance, for less cost, with increased science return through the development and use of advanced computing, information and communication technologies

  2. USSOCOM TCCC CASEVAC Set Program A Retrospective and Overview.

    Science.gov (United States)

    Gilpin, John

    2012-01-01

    The United States Special Operations Command (USSOCOM) Tactical Combat Casualty Care (TCCC) Casualty Evacuation (CASEVAC) Set Program was initiated in 2006 as a three-step effort. The initial effort was to develop an improved Individual First Aid Kit (IFAK); this was followed by the development of a Medic bag and culminated with the CASEVAC Set. The intent of the Program is both standardizing the medical load out across SOF components and expanding the skill set of Special Operations Forces (SOF) medical practitioners by providing equipment and training outside the normal parameters of many units. Even though the Set is currently being fielded to a variety of units, there are still personnel unaware of the Set and its capabilities. The goal of this article is to increase awareness of the existence of the program and to promote thought/discussion regarding the expansion of the capabilities of the Advanced Tactical Practitioner (ATP) beyond traditional medical skills. This program is best understood by first looking back to where it originated, and then examining where it is at present. 2012.

  3. Overview of the Hemostasis Research Program: Advances and Future Directions

    Science.gov (United States)

    2004-09-01

    advanced to treat such an injury in the field. The hypothesis was that a hemostatic material could be infused into a closed body cavity by a trocar ...Research Program of the US Army Medical Research and Material Command is to reduce the morbidity and mortality resulting from injuries on the

  4. Weatherization Innovation Pilot Program: Program Overview and Philadelphia Project Highlight (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2012-01-01

    Case Study with WIPP program overview, information regarding eligibility, and successes from Pennsylvania's Commission on Economic Opportunity (CEO) that demonstrate innovative approaches that maximize the benefit of the program. The Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) recently launched the Weatherization Innovation Pilot Program (WIPP) to accelerate innovations in whole-house weatherization and advance DOE's goal of increasing the energy efficiency and health and safety of homes of low-income families. Since 2010, WIPP has helped weatherization service providers as well as new and nontraditional partners leverage non-federal financial resources to supplement federal grants, saving taxpayer money. WIPP complements the Weatherization Assistance program (WAP), which operates nation-wide, in U.S. territories and in three Native American tribes. 16 grantees are implementing weatherization innovation projects using experimental approaches to find new and better ways to weatherize homes. They are using approaches such as: (1) Financial tools - by understanding a diverse range of financing mechanisms, grantees can maximize the impact of the federal grant dollars while providing high-quality work and benefits to eligible low-income clients; (2) Green and healthy homes - in addition to helping families reduce their energy costs, grantees can protect their health and safety. Two WIPP projects (Connecticut and Maryland) will augment standard weatherization services with a comprehensive green and healthy homes approach; (3) New technologies and techniques - following the model of continuous improvement in weatherization, WIPP grantees will continue to use new and better technologies and techniques to improve the quality of work; (4) Residential energy behavior change - Two grantees are rigorously testing home energy monitors (HEMs) that display energy used in kilowatt-hours, allowing residents to monitor and reduce their

  5. Application of Geologic Mapping Based on MapGIS K9%基于MapGIS K9的地质制图的应用

    Institute of Scientific and Technical Information of China (English)

    陈立

    2011-01-01

    Geologic mapping is an important component in geographic information system. The MapGIS K9 in the geologic mapping was described briefly and the process of geologic mapping was also expounded in this article.%地质制图是地理信息系统中的一项重要的组成部分,文章简要介绍了地理信息地质制图中的MapGIS K9,并对地质制图过程进行叙述.

  6. Overview of the Intelligent Manufacturing Systems (IMS) Program

    Energy Technology Data Exchange (ETDEWEB)

    Martel, A. [Canadian IMS Secretraiat, Ottawa, (Canada); Adjemian, A. [European Commission, DG-RTD, Brussels (Belgium)

    2001-07-01

    According to its proponents, the Intelligent Manufacturing System is a highly efficient, global production system, designed as the first decisive step in ensuring that society will continue to flourish materially and spiritually. It is the gateway to advanced manufacturing and processing technologies, represented by a project-based, industry-led, government-endorsed program of cooperative research, carried out in seven industrially advanced regions of the world (Australia, Canada, Europe, Japan, Switzerland, USA, Korea). Currently, there are projects worth about $250 million in progress involving 200+ companies and 200+ research institutions. The benefits of IMS sponsorship, and the type of projects carried on as part of the program (e.g. projects dealing with total product life cycle issues, process issues, strategy/planning /design tools, human/organisation/social issues, virtual/extended enterprise issues) are discussed.

  7. Geothermal program overview: Fiscal years 1993--1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    The DOE Geothermal Energy Program is involved in three main areas of research: finding and tapping the resource; power generation; and direct use of geothermal energy. This publication summarizes research accomplishments for FY 1993 and 1994 for the following: geophysical and geochemical technologies; slimhole drilling for exploration; resource assessment; lost circulation control; rock penetration mechanics; instrumentation; Geothermal Drilling Organization; reservoir analysis; brine injection; hot dry rock; The Geysers; Geothermal Technology Organization; heat cycle research; advanced heat rejection; materials development; and advanced brine chemistry.

  8. Overview of recent activities in the Heat Cycle Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Bliem, C.J.; Mines, G.L.

    1987-01-01

    The Heat Cycle Research Program, which is being conducted for the Department of Energy, has as its objective the development of the technology for effecting the improved utilization of moderate temperature geothermal resources. To meet this objective, the program has as one of its goals to improve the performance of geothermal binary cycles to levels approaching the practicable thermodynamic maximum. In pursuit of this goal, tests are being conducted at the Heat Cycle Research Facility located at the DOE Geothermal Test Facility, East Mesa, California. The current testing involves the investigation of binary power cycle performance utilizing mixtures of non-adjacent hydrocarbons as the working fluids, with supercritical vaporization and in-tube condensation of the working fluid. In addition to the present test program, preparations are being made to investigate the binary cycle performance improvements which can be achieved by allowing supersaturated vapor expansions in the turbine. These efforts are anticipated to verify that through the utilization of these advanced power cycle concepts and allowing the supersaturated turbine expansions, improvements of up to 28% in the net geofluid effectiveness (net watt hours plant output per pound of geofluid) over conventional binary power plants can be achieved. Results presented for the recent testing, including those tests examining the performance of the countercurrent condenser at different tube inclinations, support the assumptions used in projected performance improvements. 3 refs., 9 figs.

  9. An overview of the NASA textile composites program

    Science.gov (United States)

    Dexter, H. Benson

    1993-01-01

    The NASA Langley Research Center is conducting and sponsoring research to explore the benefits of textile reinforced composites for civil transport aircraft primary structures. The objective of this program is to develop and demonstrate the potential of affordable textile reinforced composite materials to meet design properties and damage tolerance requirements of advanced aircraft structures. In addition to in-house research, the program includes major participation by the aircraft industry and aerospace textile companies. The major program elements include development of textile preforms, processing science, mechanics of materials, experimental characterization of materials, and development and evaluation of textile reinforced composite structural elements and subcomponents. The NASA Langley in-house research is focused on science-based understanding of resin transfer molding (RTM), development of powder-coated towpreg processes, analysis methodology, and development of a performance database on textile reinforced composites. The focus of the textile industry participation is on development of multidirectional, damage-tolerant preforms, and the aircraft industry participation is in the areas of innovative design concepts, cost-effective fabrication, and testing of textile reinforced composite structural elements and subcomponents. Textile processes such as 3-D weaving, 2-D and 3-D braiding, and knitting/stitching are being compared with conventional laminated tape processes for improved damage tolerance. Through-the-thickness reinforcements offer significant damage tolerance improvements. However, these gains must be weighed against potential loss in in-plane properties such as strength and stiffness. Analytical trade studies are underway to establish design guidelines for the application of textile material forms to meet specific loading requirements. Fabrication and testing of large structural components are required to establish the full potential of textile

  10. Gasoline toxicology: overview of regulatory and product stewardship programs.

    Science.gov (United States)

    Swick, Derek; Jaques, Andrew; Walker, J C; Estreicher, Herb

    2014-11-01

    Significant efforts have been made to characterize the toxicological properties of gasoline. There have been both mandatory and voluntary toxicology testing programs to generate hazard characterization data for gasoline, the refinery process streams used to blend gasoline, and individual chemical constituents found in gasoline. The Clean Air Act (CAA) (Clean Air Act, 2012: § 7401, et seq.) is the primary tool for the U.S. Environmental Protection Agency (EPA) to regulate gasoline and this supplement presents the results of the Section 211(b) Alternative Tier 2 studies required for CAA Fuel and Fuel Additive registration. Gasoline blending streams have also been evaluated by EPA under the voluntary High Production Volume (HPV) Challenge Program through which the petroleum industry provide data on over 80 refinery streams used in gasoline. Product stewardship efforts by companies and associations such as the American Petroleum Institute (API), Conservation of Clean Air and Water Europe (CONCAWE), and the Petroleum Product Stewardship Council (PPSC) have contributed a significant amount of hazard characterization data on gasoline and related substances. The hazard of gasoline and anticipated exposure to gasoline vapor has been well characterized for risk assessment purposes.

  11. The application of MAPGIS K9 in geological mapping%MAPGIS K9在地质制图中的应用

    Institute of Scientific and Technical Information of China (English)

    冯娟; 翟伟芳; 赵伟娜

    2016-01-01

    The product name of MAPGIS is released digital group, is China's geographic information system with full independent intellectual copyright software platform. MAPGIS K9 help drawings, graphics editing and graphics processing and other functions, is the first selection of digital industry of our country geological mapping tool. Combined with practical work, this paper introduces the MAPGIS K9 at Grid correction, point parameters editor, line editor, the pologon parameters editor, map layout design of digital mapping method and the skill.%MAPGIS是中地数码集团的产品名称,是我国具有完全自主知识版权的地理信息系统软件平台。MAPGIS K9具有机助制图、图形编辑和图形处理等多种功能,是我国地质行业数字化制图的首选工具。本文结合工作实例,介绍了MAPGIS K9在栅格数据校正、点参数编辑、线参数编辑、面参数编辑、地图版面设计等方面的数字制图方法和技巧。

  12. Spitzer ultra faint survey program (surfs up). I. An overview

    Energy Technology Data Exchange (ETDEWEB)

    Bradač, Maruša; Huang, Kuang-Han; Cain, Benjamin; Hall, Nicholas; Lubin, Lori [Department of Physics, University of California, Davis, CA 95616 (United States); Ryan, Russell; Casertano, Stefano [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Lemaux, Brian C. [Aix Marseille Université, CNRS, LAM (Laboratoire d' Astrophysique de Marseille) UMR 7326, F-13388 Marseille (France); Schrabback, Tim; Hildebrandt, Hendrik [Argelander-Institut für Astronomie, Auf Dem Hügel 71, D-53121 Bonn (Germany); Gonzalez, Anthony H. [Department of Astronomy, University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611 (United States); Allen, Steve; Von der Linden, Anja [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 382 Via Pueblo Mall, Stanford, CA 94305-4060 (United States); Gladders, Mike [The University of Chicago, The Kavli Institute for Cosmological Physics, 933 East 56th Street, Chicago, IL 60637 (United States); Hinz, Joannah; Zaritsky, Dennis [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Treu, Tommaso, E-mail: marusa@physics.ucdavis.edu [Department of Physics, University of California, Santa Barbara, CA 93106 (United States)

    2014-04-20

    Spitzer UltRa Faint SUrvey Program is a joint Spitzer and Hubble Space Telescope Exploration Science program using 10 galaxy clusters as cosmic telescopes to study z ≳ 7 galaxies at intrinsically lower luminosities, enabled by gravitational lensing, than blank field surveys of the same exposure time. Our main goal is to measure stellar masses and ages of these galaxies, which are the most likely sources of the ionizing photons that drive reionization. Accurate knowledge of the star formation density and star formation history at this epoch is necessary to determine whether these galaxies indeed reionized the universe. Determination of the stellar masses and ages requires measuring rest-frame optical light, which only Spitzer can probe for sources at z ≳ 7, for a large enough sample of typical galaxies. Our program consists of 550 hr of Spitzer/IRAC imaging covering 10 galaxy clusters with very well-known mass distributions, making them extremely precise cosmic telescopes. We combine our data with archival observations to obtain mosaics with ∼30 hr exposure time in both 3.6 μm and 4.5 μm in the central 4' × 4' field and ∼15 hr in the flanking fields. This results in 3σ sensitivity limits of ∼26.6 and ∼26.2 AB magnitudes for the central field in the IRAC 3.6 and 4.5 μm bands, respectively. To illustrate the survey strategy and characteristics we introduce the sample, present the details of the data reduction and demonstrate that these data are sufficient for in-depth studies of z ≳ 7 sources (using a z = 9.5 galaxy behind MACS J1149.5+2223 as an example). For the first cluster of the survey (the Bullet Cluster) we have released all high-level data mosaics and IRAC empirical point-spread function models. In the future we plan to release these data products for the entire survey.

  13. Human Research Program Advanced Exercise Concepts (AEC) Overview

    Science.gov (United States)

    Perusek, Gail; Lewandowski, Beth; Nall, Marsha; Norsk, Peter; Linnehan, Rick; Baumann, David

    2015-01-01

    Exercise countermeasures provide benefits that are crucial for successful human spaceflight, to mitigate the spaceflight physiological deconditioning which occurs during exposure to microgravity. The NASA Human Research Program (HRP) within the Human Exploration and Operations Mission Directorate (HEOMD) is managing next generation Advanced Exercise Concepts (AEC) requirements development and candidate technology maturation to Technology Readiness Level (TRL) 7 (ground prototyping and flight demonstration) for all exploration mission profiles from Multi Purpose Crew Vehicle (MPCV) Exploration Missions (up to 21 day duration) to Mars Transit (up to 1000 day duration) missions. These validated and optimized exercise countermeasures systems will be provided to the ISS Program and MPCV Program for subsequent flight development and operations. The International Space Station (ISS) currently has three major pieces of operational exercise countermeasures hardware: the Advanced Resistive Exercise Device (ARED), the second-generation (T2) treadmill, and the cycle ergometer with vibration isolation system (CEVIS). This suite of exercise countermeasures hardware serves as a benchmark and is a vast improvement over previous generations of countermeasures hardware, providing both aerobic and resistive exercise for the crew. However, vehicle and resource constraints for future exploration missions beyond low Earth orbit will require that the exercise countermeasures hardware mass, volume, and power be minimized, while preserving the current ISS capabilities or even enhancing these exercise capabilities directed at mission specific physiological functional performance and medical standards requirements. Further, mission-specific considerations such as preservation of sensorimotor function, autonomous and adaptable operation, integration with medical data systems, rehabilitation, and in-flight monitoring and feedback are being developed for integration with the exercise

  14. Urban Dispersion Program Overview and MID05 Field Study Summary

    Energy Technology Data Exchange (ETDEWEB)

    Allwine, K Jerry; Flaherty, Julia E.

    2007-07-31

    The Urban Dispersion Program (UDP) was a 4-year project (2004–2007) funded by the U.S. Department of Homeland Security with additional support from the Defense Threat Reduction Agency. The U.S. Environmental Protection Agency (EPA) also contributed to UDP through funding a human-exposure component of the New York City (NYC) field studies in addition to supporting an EPA scientist in conducting modeling studies of NYC. The primary goal of UDP was to improve the scientific understanding of the flow and diffusion of airborne contaminants through and around the deep street canyons of NYC. The overall UDP project manager and lead scientist was Dr. Jerry Allwine of Pacific Northwest National Laboratory. UDP had several accomplishments that included conducting two tracer and meteorological field studies in Midtown Manhattan.

  15. Geothermal energy program summary: Volume 1: Overview Fiscal Year 1988

    Science.gov (United States)

    1989-02-01

    Geothermal energy is a here-and-now technology for use with dry steam resources and high-quality hydrothermal liquids. These resources are supplying about 6 percent of all electricity used in California. However, the competitiveness of power generation using lower quality hydrothermal fluids, geopressured brines, hot dry rock, and magma still depends on the technology improvements sought by the DOE Geothermal Energy R and D Program. The successful outcome of the R and D initiatives will serve to benefit the U.S. public in a number of ways. First, if a substantial portion of our geothermal resources can be used economically, they will add a very large source of secure, indigenous energy to the nation's energy supply. In addition, geothermal plants can be brought on line quickly in case of a national energy emergency. Geothermal energy is also a highly reliable resource, with very high plant availability. For example, new dry steam plants at The Geysers are operable over 99 percent of the time, and the small flash plant in Hawaii, only the second in the United States, has an availability factor of 98 percent. Geothermal plants also offer a viable baseload alternative to fossil and nuclear plants -- they are on line 24 hours a day, unaffected by diurnal or seasonal variations. The hydrothermal power plants with modern emission control technology have proved to have minimal environmental impact. The results to date with geopressured and hot dry rock resources suggest that they, too, can be operated so as to reduce environmental effects to well within the limits of acceptability. Preliminary studies on magma are also encouraging. In summary, the character and potential of geothermal energy, together with the accomplishments of DOE's Geothermal R and D Program, ensure that this huge energy resource will play a major role in future U.S. energy markets.

  16. NASA's Radioisotope Power Systems Program Overview - A Focus on RPS Users

    Science.gov (United States)

    Hamley, John A.; McCallum, Peter W.; Sandifer, Carl E., II; Sutliff, Thomas J.; Zakrajsek, June F.

    2016-01-01

    The goal of NASA's Radioisotope Power Systems (RPS) Program is to make RPS ready and available to support the exploration of the solar system in environments where the use of conventional solar or chemical power generation is impractical or impossible to meet potential future mission needs. To meet this goal, the RPS Program manages investments in RPS technologies and RPS system development, working closely with the Department of Energy. This paper provides an overview of the RPS Program content and status, its collaborations with potential RPS users, and the approach employed to maintain the readiness of RPS to support future NASA mission concepts.

  17. Overview of computerized dietary assessment programs for research and practice in nutrition education.

    Science.gov (United States)

    Probst, Yasmine C; Tapsell, Linda C

    2005-01-01

    Computerized dietary assessment programs are often used for nutrition education research and practice. This article provides an informal overview of 29 dietary assessment programs mentioned in the literature covered by MEDLINE from 1996 to 2003, along with the components and capabilities of these programs derived from additional sources as needed. According to the literature, the advantages of using computers for dietary assessment include standardization of the questioning sequence, fast and easy processing, immediate results, and increased flexibility. The disadvantages include the need for typing skills and computer literacy, as well as potential bias in the responses if an interviewer is required.

  18. An Overview of the US DCLL ITER TBM Program

    Energy Technology Data Exchange (ETDEWEB)

    Wong, C. P. C. [General Atomics, San Diego; Abdou, M [University of California, Los Angeles; Dagher, M [University of California, Los Angeles; Katoh, Yutai [ORNL; Kurtz, Richard [Pacific Northwest National Laboratory (PNNL); Malang, Siegfried [Consultant; Marriott, Edward [University of Wisconsin, Madison; Merrill, Brad [Idaho National Laboratory (INL); Messadek, K [University of California, Los Angeles; Morley, N.B. [University of California, Los Angeles; Pint, Bruce A [ORNL; Sawan, M. [University of Wisconsin; Sharafat, S [University of California, Los Angeles; Smolentsev, Sergey [University of California, Los Angeles; Sze, Dai-Kai [University of California, San Diego; Willms, Scott [Los Alamos National Laboratory (LANL); Ying, Alice [University of California, Los Angeles; Youssef, M Z [University of California, Los Angeles

    2010-01-01

    Under the US Fusion Nuclear Science and Technology program, we selected the Dual Coolant Lead Lithium (DCLL) concept as our primary Test Blanket Module (TBM) for testing in ITER. The DCLL blanket concept has the potential to be a high-performance DEMO blanket design with a projected thermal efficiency of >40%. Reduced activation ferritic/martensitic (RAF/M) steel is used as the structural material. Helium is used to cool the first wall and blanket structure, and the self-cooled Pb-17Li breeder is circulated for power conversion and for tritium extraction. A SiC-based flow channel insert (FCI) is used as an electrical insulator for magnetohydrodynamic pressure drop reduction from the circulating Pb-17Li and as a thermal insulator to separate the high-temperature Pb-17Li ({approx}650-700 C) from the RAF/M structure, which has a corrosion temperature limit of {approx}480 C. The RAF/M material must also operate at temperatures above 350 C but less than 550 C. We are continuing the development of the mechanical design and performing neutronics, structural and thermal hydraulics analyses of the DCLL TBM module. Prototypical FCI structures were fabricated and further attention was paid to MHD effects and the design of the inboard blanket for DEMO. We are also making progress on related R&D needs to address key areas. This paper is a summary report on the progress and results of recent DCLL TBM development activities.

  19. An overview of the US DCLL ITER-TBM program

    Energy Technology Data Exchange (ETDEWEB)

    Wong, C.P.C., E-mail: wongc@fusion.gat.com [General Atomics, P.O. Box, 85608, San Diego, CA, 92186-5608 (United States); Abdou, M.; Dagher, M. [University of California-Los Angeles, CA (United States); Katoh, Y. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Kurtz, R.J. [Pacific Northwest National Laboratory, Richland, WA (United States); Malang, S. [Fusion Nuclear Technology Consulting, Linkenheim (Germany); Marriott, E.P. [University of Wisconsin, Madison, WI (United States); Merrill, B.J. [Idaho National Laboratory, Idaho Falls, ID (United States); Messadek, K.; Morley, N.B. [University of California-Los Angeles, CA (United States); Sawan, M.E. [University of Wisconsin, Madison, WI (United States); Sharafat, S.; Smolentsev, S. [University of California-Los Angeles, CA (United States); Sze, D.K. [University of California-San Diego, La Jolla, CA (United States); Willms, S. [Los Alamos National Laboratory, Los Alamos, NM (United States); Ying, A.; Youssef, M.Z. [University of California-Los Angeles, CA (United States)

    2010-12-15

    Under the US Fusion Nuclear Science and Technology program, we selected the Dual Coolant Lead Lithium (DCLL) concept as our primary Test Blanket Module (TBM) for testing in ITER. The DCLL blanket concept has the potential to be a high-performance DEMO blanket design with a projected thermal efficiency of >40%. Reduced activation ferritic/martensitic (RAF/M) steel is used as the structural material. Helium is used to cool the first wall and blanket structure, and the self-cooled Pb-17Li breeder is circulated for power conversion and for tritium extraction. A SiC-based flow channel insert (FCI) is used as an electrical insulator for magnetohydrodynamic pressure drop reduction from the circulating Pb-17Li and as a thermal insulator to separate the high-temperature Pb-17Li ({approx}650-700 deg. C) from the RAF/M structure, which has a corrosion temperature limit of {approx}480 deg. C. The RAF/M material must also operate at temperatures above 350 deg. C but less than 550 deg. C. We are continuing the development of the mechanical design and performing neutronics, structural and thermal hydraulics analyses of the DCLL TBM module. Prototypical FCI structures were fabricated and further attention was paid to MHD effects and the design of the inboard blanket for DEMO. We are also making progress on related R and D needs to address key areas. This paper is a summary report on the progress and results of recent DCLL TBM development activities.

  20. Overview of Westinghouse`s Advanced Turbine Systems Program

    Energy Technology Data Exchange (ETDEWEB)

    Bannister, R.L.; Bevc, F.P.; Diakunchak, I.S.; Huber, D.J. [Westinghouse Electric Corp., Orlando, FL (United States)

    1995-10-01

    Westinghouse`s experience with land based gas turbines started in 1945 with the development of a 2000 hp gas turbine-generator set that consisted of a single reduction gear, compressor, 12 combustors and turbine. A thermal efficiency of 18% was obtained. By 1954, Westinghouse had developed a 15 MW unit (with a regenerator and intercooler) that was designed for a full-load simple cycle efficiency of 29%. As the initial step in the Advanced Turbine Systems (ATS) program, Westinghouse has already developed a 230 MW gas turbine that has a simple cycle efficiency of 38.5% without the use of regeneration and intercooler concepts. In 1967, Westinghouse developed its first gas turbine combined cycle, a synergistic combination of the Brayton and the Rankine cycles. In a combined cycle the heat rejected by the higher temperature topping cycle is recovered in the lower temperature bottoming cycle to produce additional power from the energy initially released by the fuel. In this first Westinghouse combined cycle, a 1450{degrees}F burner outlet temperature gas turbine, rated at 25 MW, supplied exhaust heat which was used in a boiler to furnish steam to drive an 85 MW steam turbine. This plant achieved an annual average efficiency of 39.6%.

  1. An overview of the Nuclear Materials Focus Area research program

    Energy Technology Data Exchange (ETDEWEB)

    ROBERSON,GARY D.; POLANSKY,GARY F.; OSBORNE,KEN K.; RANDALL,VIRGINIA

    2000-02-25

    The Nuclear Material Focus Area (NMFA) is responsible for providing comprehensive needs identification, integration of technology research and development activities, and technology deployment for stabilization, packaging, and interim storage of surplus nuclear materials within the DOE complex. The NMFA was chartered in April 1999 by the Office of Science and Technology (OST), an organizational component of the US Department of Energy's (DOE) Office of Environmental Management (EM). OST manages a national program to conduct basic and applied research, and technology development, demonstration, and deployment assistance that is essential to completing a timely and cost-effective cleanup of the DOE nuclear weapons complex. DOE/EM provides environmental research results, as well as cleanup technologies and systems, to meet high-priority end-user needs, reduce EM's major cost centers and technological risks, and accelerate technology deployments. The NMFA represents the segment of EM that focuses on technological solutions for re-using, transforming, and disposing excess nuclear materials and is jointly managed by the DOE Albuquerque Operations Office and the DOE Idaho Operations Office.

  2. NASA F-16XL supersonic laminar flow control program overview

    Science.gov (United States)

    Fischer, Michael C.

    1992-01-01

    The viewgraphs and discussion of the NASA supersonic laminar flow control program are provided. Successful application of laminar flow control to a High Speed Civil Transport (HSCT) offers significant benefits in reductions of take-off gross weight, mission fuel burn, cruise drag, structural temperatures, engine size, emissions, and sonic boom. The ultimate economic success of the proposed HSCT may depend on the successful adaption of laminar flow control, which offers the single most significant potential improvements in lift drag ratio (L/D) of all the aerodynamic technologies under consideration. The F-16XL Supersonic Laminar Flow Control (SLFC) Experiment was conceived based on the encouraging results of in-house and NASA supported industry studies to determine if laminar flow control is feasible for the HSCT. The primary objective is to achieve extensive laminar flow (50-60 percent chord) on a highly swept supersonic wing. Data obtained from the flight test will be used to validate existing Euler and Navier Stokes aerodynamic codes and transition prediction boundary layer stability codes. These validated codes and developed design methodology will be delivered to industry for their use in designing supersonic laminar flow control wings. Results from this experiment will establish preliminary suction system design criteria enabling industry to better size the suction system and develop improved estimates of system weight, fuel volume loss due to wing ducting, turbocompressor power requirements, etc. so that benefits and penalties can be more accurately assessed.

  3. 2003 Biology and Biotechnology Research Program Overview and Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Prange, C

    2003-03-01

    LLNL conducts multidisciplinary bioscience to fill national needs. Our primary roles are to: develop knowledge and tools which enhance national security, including biological, chemical and nuclear capabilities, and energy and environmental security; develop understanding of genetic and biochemical processes to enhance disease prevention, detection and treatment; develop unique biochemical measurement and computational modeling capabilities which enable understanding of biological processes; and develop technology and tools which enhance healthcare. We execute our roles through integrated multidisciplinary programs that apply our competencies in: microbial and mammalian genomics--the characterization of DNA, the genes it encodes, their regulation and function and their role in living systems; protein function and biochemistry - the structure, function, and interaction of proteins and other molecules involved in the integrated biochemical function of the processes of life; computational modeling and understanding of biochemical systems--the application of high-speed computing technology to simulate and visualize complex, integrated biological processes; bioinformatics--databasing, networking, and analysis of biological data; and bioinstrumentation--the application of physical and engineering technologies to novel biological and biochemical measurements, laboratory automation, medical device development, and healthcare technologies. We leverage the Laboratory's exceptional capabilities in the physical, computational, chemical, environmental and engineering sciences. We partner with industry and universities to utilize their state-of-the art technology and science and to make our capabilities and discoveries available to the broader research community.

  4. An Overview of Recent PISCES Program PMI Results

    Science.gov (United States)

    Tynan, George; Doerner, Russell; Abe, Shota; Baldwin, Matthew; Barton, Joseph; Chen, Renkun; Gosselin, Jordan; Hollmann, Eric; Nishijima, Daisuke; Simmonds, Michael; Wang, Yong; Yu, Jonathan

    2015-11-01

    The PISCES Program is focused on fundamental PMI studies of Be and W-based solid plasma facing components under steady-state and transient conditions. We will show results from studies in W, Be and mixed W-Be material systems. Topics of investigation include formation of near-surface nanobubbles from He plasma ion implantation, growth of W-fuzz from these bubbles in steady-state and transient conditions, D retention in Be and W and development of a D-retention model for both H/D isotope exchange and displacement damage experiments. Initial studies of PMI in displacement damaged W are also presented, showing the effect of damage and exposure temperature on D retention, D diffusion, W thermal conductivity. Be-based results include morphology evolution under high plasma flux exposure, Be erosion mechanisms, and retention in Be-based materials. Future plans and connections to fusion energy system requirements will be discussed. This work supported by grant DE-FG02-07ER54912.

  5. Laboratory support of drug abuse control programs: an overview.

    Science.gov (United States)

    Decker, W J

    1977-01-01

    Labeling an individual a drug abuser has serious sociologic and legal implications that only laboratory testing can effectively allay. A proper specimen (both qualitatively and quantitatively) must be obtained for analysis. Positive identification of specimen with subject is of paramount importance. The problems of specimen substitution--other people's urine, tap water, apple juice--directly impinge here, as does the possibility of drug degradation by heat, light, and microbial attack and of drug adsorption by the container and urinary sediment. Confirmation of postives indicated by screening tests (thin layer chromatography and immunoassays) by gas chromatography and/or ultraviolet spectrophotometry is, in most situations, mandatory. An effective quality control program is an absolute requirement. Even under ideal circumstances, laboratory results can sometimes wrongly indicate the abuse of drugs; and conversely, drug abuse can take place without detection by the laboratory. As in any clinical situation, laboratory tests are only a part (albeit an important one) of the entire evaluation of the individual involved.

  6. Overview of multilayer ceramic actuator program at C-MET

    Science.gov (United States)

    Raghu, N.; Kumar, V.; Dayas, K. R.; Rao, I. C.

    2003-10-01

    One of the major programs being undertaken in our unit is, development of actuator materials and conversion of these materials into multilayer actuator devices. In order to achieve this objective, development of piezoelectric and electrostrictive materials are also being attempted. A simple and novel chemical precipitation route has been adopted for the synthesis of nano-actuator materials. Lead Zirconate Titanate (PZT) powder, free of agglomerates, phase pure, good chemical homogeneity and of 50 - 75 nm size has been synthesized. Synthesis of nano Ba(Sn,Ti)O3 which shows linear, nearly hysteresis free strain curve is also discussed. Phase pure electrostrictive Lead Magnesium Niobate-Lead Titanate (PMN-PT) powder with a dielectric constant of 25,000 and a Tc of 38°C was prepared through double-step process. C-MET has state of the art facility for multilayer (ML) ceramic processing. These Nano-PZT powders have been converted into 50 micron green tapes through tape casting technique. Characteristics of these synthesized materials and the fabrication of ML actuators there from are presented.

  7. An overview of the US DCLL ITER-TBM program

    Energy Technology Data Exchange (ETDEWEB)

    Wong, C. P. C.; Abdou, M.; Dagher, M.; Katoh, Y.; Kurtz, R. J.; Malang, S.; Marriott, E. P.; Merrill, B. J.; Messadek, K.; Morley, N. B.; Sawan, M. E.; Sharafat, S.; Smolentsev, S.; Sze, D. K.; Willms, S.; Ying, A.; Youssef, M. Z.

    2010-12-01

    Under the US Fusion Nuclear Science and Technology program, we selected the Dual Coolant Lead Lithium (DCLL) concept as our primary Test Blanket Module (TBM) for testing in ITER. The DCLL blanket concept has the potential to be a high-performance DEMO blanket design with a projected thermal efficiency of >40%. Reduced activation ferritic/martensitic (RAF/M) steel is used as the structural material. Helium is used to cool the first wall and blanket structure, and the self-cooled Pb-17Li breeder is circulated for power conversion and for tritium extraction. A SiC-based flow channel insert (FCI) is used as an electrical insulator for magnetohydrodynamic pressure drop reduction from the circulating Pb-17Li and as a thermal insulator to separate the high-temperature Pb-17Li (~650–700 °C) from the RAF/M structure, which has a corrosion temperature limit of ~480 °C. The RAF/M material must also operate at temperatures above 350 °C but less than 550 °C. We are continuing the development of the mechanical design and performing neutronics, structural and thermal hydraulics analyses of the DCLL TBM module. Prototypical FCI structures were fabricated and further attention was paid to MHD effects and the design of the inboard blanket for DEMO. We are also making progress on related R&D needs to address key areas. Finally, this paper is a summary report on the progress and results of recent DCLL TBM development activities.

  8. TERRAPOWER, LLC TRAVELING WAVE REACTOR DEVELOPMENT PROGRAM OVERVIEW

    Directory of Open Access Journals (Sweden)

    PAVEL HEJZLAR

    2013-11-01

    burden. This paper describes the origins and current status of the TWR development program at TerraPower, LLC. Some of the areas covered include the key TWR design challenges and brief descriptions of TWR-Prototype (TWR-P reactor. Selected information on the TWR-P core designs are also provided in the areas of neutronic, thermal hydraulic and fuel performance. The TWR-P plant design is also described in such areas as; system design descriptions, mechanical design, and safety performance.

  9. An Overview of the NASA Aeronautics Test Program Strategic Plan

    Science.gov (United States)

    Marshall, Timothy J.

    2010-01-01

    U.S. leadership in aeronautics depends on ready access to technologically advanced, efficient, and affordable aeronautics test capabilities. These systems include major wind tunnels and propulsion test facilities and flight test capabilities. The federal government owns the majority of the major aeronautics test capabilities in the United States, primarily through the National Aeronautics and Space Administration (NASA) and the Department of Defense (DoD), however an overarching strategy for management of these national assets was needed. Therefore, in Fiscal Year (FY) 2006 NASA established the Aeronautics Test Program (ATP) as a two-pronged strategic initiative to: (1) retain and invest in NASA aeronautics test capabilities considered strategically important to the agency and the nation, and (2) establish a strong, high level partnership with the DoD Test Resources Management Center (TRMC), stewards of the DoD test and evaluation infrastructure. Since then, approximately seventy percent of the ATP budget has been directed to underpin fixed and variable costs of facility operations within its portfolio and the balance towards strategic investments in its test facilities, including maintenance and capability upgrades. Also, a strong guiding coalition was established through the National Partnership for Aeronautics Testing (NPAT), with governance by the senior leadership of NASA s Aeronautics Research Mission Directorate (ARMD) and the DoD's TRMC. As part of its strategic planning, ATP has performed or participated in many studies and analyses, including assessments of major NASA and DoD aeronautics test capabilities, test facility condition evaluations and market research. The ATP strategy has also benefitted from unpublished RAND research and analysis by Ant n et al. (2009). Together, these various studies, reports and assessments serve as a foundation for a new, five year strategic plan that will guide ATP through FY 2014. Our vision for the future is a balanced

  10. Study on damage of K9 glass under 248nm ultraviolet pulsed laser irradiation

    Science.gov (United States)

    Wang, Xi; Fang, Xiaodong

    2015-04-01

    The damage of K9 glass under 248nm ultraviolet pulsed laser irradiation was studied. The laser pulse energy was kept within the range of 60mJ to 160mJ, and the repetition rate was adjusted within the range of 1Hz to 40Hz. The damage morphologies of single-pulse and multi-pulse laser irradiation were characterized by optical microscope, and the damage mechanism was discussed. The experimental results indicated that the damage of K9 glass irradiated by 248nm ultraviolet laser mainly followed the thermal-mechanical coupling mechanism and the damage threshold of K9 glass was 2.8J/cm2. The intensity of damage area increased gradually with the increase of the laser pulse number. It was shown that accumulation effect of laser induced damage to K9 glass was obvious.

  11. 比亚迪K9登陆武汉和曼谷

    Institute of Scientific and Technical Information of China (English)

    张艳

    2015-01-01

    3月1日,比亚迪绿色公交正式登陆武汉,2辆K9纯电动大巴走上武汉街头。作为全球首款全通道低地板纯电动公交,K9为武汉市民的绿色出行增添新动力。武汉K9纯电动大巴采用白绿色车身,简洁大方。首批2辆K9投放在武汉295路公交线路,从汉口火车站开往黄陂客运站,单车载客往返一次60个站点、约80公里,运营时间约3小时。

  12. TALE-directed local modulation of H3K9 methylation shapes exon recognition.

    Science.gov (United States)

    Bieberstein, Nicole I; Kozáková, Eva; Huranová, Martina; Thakur, Prasoon K; Krchňáková, Zuzana; Krausová, Michaela; Carrillo Oesterreich, Fernando; Staněk, David

    2016-07-21

    In search for the function of local chromatin environment on pre-mRNA processing we established a new tool, which allows for the modification of chromatin using a targeted approach. Using Transcription Activator-Like Effector domains fused to histone modifying enzymes (TALE-HME), we show locally restricted alteration of histone methylation modulates the splicing of target exons. We provide evidence that a local increase in H3K9 di- and trimethylation promotes inclusion of the target alternative exon, while demethylation by JMJD2D leads to exon skipping. We further demonstrate that H3K9me3 is localized on internal exons genome-wide suggesting a general role in splicing. Consistently, targeting of the H3K9 demethylase to a weak constitutive exon reduced co-transcriptional splicing. Together our data show H3K9 methylation within the gene body is a factor influencing recognition of both constitutive and alternative exons.

  13. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis

    OpenAIRE

    Wang, Lifeng; Xu, Shiliyang; Lee, Ji-Eun; Baldridge, Anne; Grullon, Sean; Peng, Weiqun; Ge, Kai

    2012-01-01

    PPARγ promotes adipogenesis while Wnt proteins inhibit adipogenesis. However, the mechanisms that control expression of these positive and negative master regulators of adipogenesis remain incompletely understood. By genome-wide histone methylation profiling in preadipocytes, we find that among gene loci encoding adipogenesis regulators, histone methyltransferase (HMT) G9a-mediated repressive epigenetic mark H3K9me2 is selectively enriched on the entire PPARγ locus. H3K9me2 and G9a levels dec...

  14. Numerical simulation of temperature field in K9 glass irradiated by ultraviolet pulse laser

    Science.gov (United States)

    Wang, Xi; Fang, Xiaodong

    2015-10-01

    The optical component of photoelectric system was easy to be damaged by irradiation of high power pulse laser, so the effect of high power pulse laser irradiation on K9 glass was researched. A thermodynamic model of K9 glass irradiated by ultraviolet pulse laser was established using the finite element software ANSYS. The article analyzed some key problems in simulation process of ultraviolet pulse laser damage of K9 glass based on ANSYS from the finite element models foundation, meshing, loading of pulse laser, setting initial conditions and boundary conditions and setting the thermal physical parameters of material. The finite element method (FEM) model was established and a numerical analysis was performed to calculate temperature field in K9 glass irradiated by ultraviolet pulse laser. The simulation results showed that the temperature of irradiation area exceeded the melting point of K9 glass, while the incident laser energy was low. The thermal damage dominated in the damage mechanism of K9 glass, the melting phenomenon should be much more distinct.

  15. The NASA Electronic Parts and Packaging (NEPP) Program: NEPP Overview - Automotive Electronics

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2016-01-01

    The results of NASAs studies into the appropriateness of using U.S. Automotive electronic parts in NASA spaceflight systems will be presented. The first part of the presentation provides an overview of the United States Automotive Electronics Council's AECQ standardization program, the second part provides a summary of the results of NASA's procurement and testing experiences and other lessons learned along with preliminary test results.

  16. Overview 2010 of ARL Program on Network Science for Human Decision Making

    Science.gov (United States)

    2011-01-01

    IN FRACTAL PHYSIOLOGY       OVERVIEW 2010 OF ARL PROGRAM ON NETWORK SCIENCE FOR HUMAN DECISION MAKING   Bruce J West Journal Name: Frontiers in...2:76. doi:10.3389/fphys.2011.00076 Article URL: http://www.frontiersin.org/Journal/Abstract.aspx?s=454& name= fractal %20physiology&ART_DOI=10.3389...functions: transportation, electrical power, food distribution, finance , and health care to name a few. The 1 2 interoperability of these networks

  17. Data Conversion Between AutoCAD and MapGIS K9%AutoCAD与MapGIS K9数据转换

    Institute of Scientific and Technical Information of China (English)

    郑贵洲; 姚昳昕; 彭俊芳

    2013-01-01

    介绍了两种软件的数据特点和数据格式,阐述了AutoCAD和MapGIS K9块与子图、线型、颜色、图案、图层之间对照关系表的建立方法,详细概括了实现两种格式间数据转换的过程.

  18. Mobilizing communities: an overview of the Community Coalition Partnership Programs for the Prevention of Teen Pregnancy.

    Science.gov (United States)

    Cassell, Carol; Santelli, John; Gilbert, Brenda Colley; Dalmat, Michael; Mezoff, Jane; Schauer, Mary

    2005-09-01

    The Community Coalition Partnership Programs for the Prevention of Teen Pregnancy (CCPP) was a seven-year (1995-2002) demonstration program funded by the Centers for Disease Control and Prevention (CDC) Division of Reproductive Health conducted in 13 U.S cities. The purpose of the CCPP was to demonstrate whether community partners could mobilize and organize community resources in support of comprehensive, effective, and sustainable programs for the prevention of initial and subsequent pregnancies. This article provides a descriptive overview of the program origins, intentions, and efforts over its planning and implementation phases, including specific program requirements, needs and assets assessments, intervention focus, CDC support for evaluation efforts, implementation challenges, and ideas for translation and dissemination. CDC hopes that the experiences gained from this effort lead to a greater understanding of how to mobilize community coalitions as an intervention to prevent teen pregnancy and address other public health needs.

  19. Overview of ORNL/NRC programs addressing durability of concrete structures

    Energy Technology Data Exchange (ETDEWEB)

    Naus, D.J.; Oland, C.B.

    1994-06-01

    The role of reinforced concrete relative to its applications as either safety-related structures in nuclear power or engineered barriers of low-level radioactive waste disposal facilities is described. Factors that can affect the long-term durability of reinforced concrete are identified. Overviews are presented of the Structural Aging Program, which is addressing the aging management of safety-related concrete structures in nuclear power plants, and the Permeability Test Methods and Data Program, which is identifying pertinent data and information for use in performance assessments of engineered barriers for low-level radioactive waste disposal.

  20. Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis

    Science.gov (United States)

    Maeda, Kazuya; Doi, Shigehiro; Nakashima, Ayumu; Nagai, Takuo; Irifuku, Taisuke; Ueno, Toshinori; Masaki, Takao

    2017-01-01

    Activity of H3K9 histone methyltransferase G9a is reportedly induced by transforming growth factor-β1 (TGF-β1) and plays an important role in the progression of cancer and fibrosis. In this study, we investigated whether inhibition of G9a-mediated H3K9 methylation attenuates peritoneal fibrosis in mice and human peritoneal mesothelial cells (HPMCs). Nonadherent cells of peritoneal dialysis (PD) patients were isolated from PD effluent to examine expression of G9a. Peritoneal fibrosis was induced by peritoneal injection of methylglyoxal (MGO) in male C57/B6 mice for 3 weeks. BIX01294, a G9a inhibitor, was administered by subcutaneous injection. Effects of BIX01294 on MGO-induced pathological and functional changes in mice were evaluated by immunohistochemistry and a peritoneal equilibration test. HPMCs were isolated from human omentum, and the inhibitory effect of BIX01294 on TGF-β1-induced fibrotic changes was investigated in the HPMCs by western blotting. G9a was upregulated in nonadherent cells of human PD effluent, the peritoneum of MGO-injected mice, and TGF-β1-stimulated HPMCs. BIX01294 significantly reduced the submesothelial zone thickness and cell density in MGO-injected mice. Immunohistochemical staining revealed that BIX01294 treatment decreased not only mono-methylation of H3K9 (H3K9me1), but also the number of mesenchymal cells, accumulation of collagen, and infiltration of monocytes. In addition to the pathological changes, BIX01294 reduced the level of TGF-β1 in peritoneal fluid and improved peritoneal functions. Furthermore, BIX01294 inhibited TGF-β1-induced fibrotic changes along with suppression of H3K9me1 in HPMCs. Therefore, inhibition of H3K9 methyltransferase G9a suppresses peritoneal fibrosis through a reduction of H3K9me1. PMID:28278257

  1. Overview of nuclear education and outreach program among Malaysian school students

    Science.gov (United States)

    Sahar, Haizum Ruzanna; Masngut, Nasaai; Yusof, Mohd Hafizal; Ngadiron, Norzehan; Adnan, Habibah

    2017-01-01

    This paper gives an overview of nuclear education and outreach program conducted by Agensi Nuklear Malaysia (Nuklear Malaysia) throughout its operation and establishment. Since its foundation in 1972, Nuklear Malaysia has been the pioneer and is competent in the application of nuclear science and technology. Today, Nuklear Malaysia has ventured and eventually contributed into the development of various socio-economic sectors which include but not limited to medical, industry, manufacturing, agriculture, health, radiation safety and environment. This paper accentuates on the history of education and outreach program by Nuklear Malaysia, which include its timeline and evolution; as well as a brief on education and outreach program management, involvement of knowledge management as part of its approach and later the future of Nuklear Malaysia education and outreach program.

  2. Influence of ion beam bombardment on surface roughness of K9 glass substrate

    Science.gov (United States)

    Pan, Yongqiang; Huang, Guojun; Hang, Lingxia

    2010-10-01

    Ion beam bombardment optical substrate surface has become an important part of process of optical thin films deposition. In this work, the K9 optical glass is bombarded by the broad beam cold cathode ion source. The dependence of the K9 glass surface roughness on the ion beam bombardment time, the ion energy, the distance and incident angle are all investigated, respectively. Surface roughness of K9 glass is measured using Talysurf CCI. The experimental results show that when the ion energy is 800ev, the bombardment distance of 20cm, with the ion beam bombardment time increased, the K9 substrate surface roughness first increase and then decrease. When the ion beam bombardment distance is 20cm, bombardment time is 10min, with the bombardment energy increases, substrate surface roughness increase first and then decrease, especially in the ion energy greater than 1200ev, the optical substrate surface roughness rapidly increases. When the ion energy is 800 eV, bombardment time is 10min, with the bombardment distance increase, substrate surface roughness decrease gradually. Furthermore, the incident angle of ion beam plays an important role in improving the K9 glass surface roughness.

  3. 起亚旗舰K9正式发布

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    起亚目前发布了全新研发的旗舰豪华轿车——K9,新车将于2012年上半年在韩国上市销售。起亚表示K9也将在2012年年底销往韩国以外的市场,但尚未透露海外市场的车名和准确发布时间。全新K9是起亚旗下首款后驱轿车,将被作为起亚的旗舰车系替代2010年退市的欧菲莱斯(Opirus,又称为Amanti),但定位将有所提升。起亚表示K9拥有出类拔萃的设计和操控乐趣,并拥有大量先进技术,这表示我们可以将K9视为起亚最高研发和制造水平的展现。

  4. Environmental effects monitoring at the Terra Nova offshore oil development (Newfoundland, Canada): Program design and overview

    Science.gov (United States)

    DeBlois, Elisabeth M.; Tracy, Ellen; Janes, G. Gregory; Crowley, Roger D.; Wells, Trudy A.; Williams, Urban P.; Paine, Michael D.; Mathieu, Anne; Kilgour, Bruce W.

    2014-12-01

    An environmental effects monitoring (EEM) program was developed by Suncor (formerly Petro-Canada) in 1997/98 to assess effects of the Terra Nova offshore oil and gas development on the receiving environment. The Terra Nova Field is located on the Grand Banks approximately 350 km southeast of Newfoundland (Canada), at approximately 100 m water depth. The EEM program was developed with guidance from experts in government, academia and elsewhere, and with input from the public. The EEM program proposed by Suncor was accepted by Canadian regulatory agencies and the program was implemented in 2000, 2001, 2002, 2004, 2006, 2008 and 2010, with pre-development sampling in 1997. The program continues to be implemented every two years. EEM includes an assessment of alterations in sediment quality through examination of changes in sediment chemistry, particle size, toxicity and benthic invertebrate community structure. A second component of the program examines potential effects on two species of commercial fishing interest: Iceland scallop (Chlamys islandica) and American plaice (Hippoglossoides platessoides). Chemical body burden for these two species is examined and taste tests are performed to assess the presence of taint in edible tissues. Effects on American plaice bioindicators are also examined. A final component of the program assesses potential effects of the Terra Nova development on water quality and examines water column chemistry, chlorophyll concentration and physical properties. The papers presented in this collection focus on effects of drill cuttings and drilling muds on the seafloor environment and, as such, report results on sediment quality and bioaccumulation of drilling mud components in Iceland scallop and American plaice. This paper provides information on drilling discharges, an overview of the physical oceanography at the Terra Nova Field, and an overview of the field program designed to assess environmental effects of drilling at Terra Nova.

  5. 浅析MapGIS K9的应用技术

    Institute of Scientific and Technical Information of China (English)

    李莉英

    2013-01-01

    MapGIS K9是采用新一代GIs架构技术和开发模式,面向网络超大型分布式地理信息系统基础软件平台.MapGIS K9中地质制图是一项重要的组成部分,文章简述MapGIS K9在地质制图中的应用技术,以便为地质制图人员提供参考.地质制图是一项较为复杂的综合性工作,它需要制图人员在大量地质调查的基础上,运用先进技术完成制图工作.

  6. 起亚旗舰车型K9韩国上市

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    日前,现代起亚汽车全新旗舰车型K9正式在韩国上市销售。全新起亚K9豪华轿车与现代雅科仕共享技术平台,它出自前奥迪设计师彼得·希瑞尔之手,外形更加优雅、时尚。全新起亚K9装备了3.8L排量V6汽油发动机,最高输出功率210kW。

  7. File list: His.PSC.50.H3K9K14ac.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.H3K9K14ac.AllCell mm9 Histone H3K9K14ac Pluripotent stem cell ERX245530,...1 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.H3K9K14ac.AllCell.bed ...

  8. File list: His.PSC.20.H3K9ac.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.H3K9ac.AllCell hg19 Histone H3K9ac Pluripotent stem cell SRX067524,SRX03...8537,SRX951984,SRX951983,SRX038538,SRX095381 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.H3K9ac.AllCell.bed ...

  9. Study on fine annealing process of the large-aperture K9 glasses

    Science.gov (United States)

    Gang, Wang; Bin, Liu Yi; Zheng, Li Li; Hui, Zhang; Lei, Xie; Min, Qiu Fu; Ping, Ma; Yao, Yan Ding

    2016-10-01

    Study on fine annealing process of the large-aperture K9 glasses was carried out in the report. The process parameters of glass placed way, fan speed and design of the cavity for keeping temperature uniformity were attained. By the fine annealing experiment, the stress distribution was improved evidently. The stress changed from Irregular distribution to consistency symmetric distribution and the stress max was reduced. The surface profile accuracy of the large-aperture K9 glasses was controlled steadily during CNC polishing.

  10. Agent oriented programming: An overview of the framework and summary of recent research

    Science.gov (United States)

    Shoham, Yoav

    1993-01-01

    This is a short overview of the agent-oriented programming (AOP) framework. AOP can be viewed as an specialization of object-oriented programming. The state of an agent consists of components called beliefs, choices, capabilities, commitments, and possibly others; for this reason the state of an agent is called its mental state. The mental state of agents is captured formally in an extension of standard epistemic logics: beside temporalizing the knowledge and belief operators, AOP introduces operators for commitment, choice and capability. Agents are controlled by agent programs, which include primitives for communicating with other agents. In the spirit of speech-act theory, each communication primitive is of a certain type: informing, requesting, offering, etc. This document describes these features in more detail and summarizes recent results and ongoing AOP-related work.

  11. A brief overview of NASA Langley's research program in formal methods

    Science.gov (United States)

    1992-01-01

    An overview of NASA Langley's research program in formal methods is presented. The major goal of this work is to bring formal methods technology to a sufficiently mature level for use by the United States aerospace industry. Towards this goal, work is underway to design and formally verify a fault-tolerant computing platform suitable for advanced flight control applications. Also, several direct technology transfer efforts have been initiated that apply formal methods to critical subsystems of real aerospace computer systems. The research team consists of six NASA civil servants and contractors from Boeing Military Aircraft Company, Computational Logic Inc., Odyssey Research Associates, SRI International, University of California at Davis, and Vigyan Inc.

  12. An overview of U.S. predoctoral dental implant programs and their directors.

    Science.gov (United States)

    Barwacz, Christopher A; Avila-Ortiz, Gustavo; Allareddy, Veerasathpurush; Tamegnon, Monelle; Hoogeveen, Kaitlin

    2015-03-01

    The aim of this study was to provide an overview of current predoctoral implant programs in the United States, including curricular characteristics and clinical practices regarding implant therapy education and program directors' characteristics. An electronic survey was sent to predoctoral implant program directors of all 64 accredited U.S. dental schools; 52 of the 60 eligible programs responded, for a response rate of 87%. The responding program directors were primarily affiliated with either prosthodontics departments (44%) or restorative dentistry departments (40%). Structurally, 80.8% of the responding schools integrate their implant programs into the third year of the curriculum. Clinical implant therapy exercises reported were simulation exercises without direct patient care (90.4% of responding schools) and direct patient care under supervision (94.2%). The most frequently taught restorative modalities are posterior single-tooth implant crown (96.2%), mandibular implant-retained overdenture (88.5%), and anterior implant-supported single crown (61.5%). A majority (74.5%) of responding programs utilize analog surgical guide planning, while 25.5% reported use of digital guided surgery planning software. All schools in the Northwest and 66.7% in the South Central regions utilize custom abutments as the primary abutment design, while a majority of schools in the North Central (62.5%), Northeast (53.8%), Southwest (66.7%), and Southeast (80%) regions use stock abutments (p=0.02). Regional differences were significant with regard to fixation modality, with all the Northwest programs using screw retention and 90% of Southeast and 87.5% of North Central programs using cement retention (p=0.002). This study demonstrated that while institutions share program director and curricular similarities, clinical practices and modalities vary significantly by region.

  13. Gradual development of a genome-wide H3-K9 trimethylation pattern in paternally derived pig pronucleus.

    Science.gov (United States)

    Jeong, Young Sun; Yeo, Seungeun; Park, Jung Sun; Lee, Kyung-Kwang; Kang, Yong-Kook

    2007-06-01

    The cytoplasm of a mature oocyte contains many protein complexes that are programmed to restructure incoming sperm chromatins on fertilization. Of the complicated biochemical events that these functional machineries control, the most impressive and important is epigenetic reprogramming. Despite its importance in epigenetic resetting, or "de-differentiation," of gamete genomes back to an incipient status, the mechanisms of epigenetic reprogramming do not seem to be conserved among mammals. Here, we report that, unlike in the mouse, the pig sperm-derived pronucleus is markedly trimethylated at lysine 9 of histone H3 (H3-m(3)K9), which might be associated with preservation of paternally derived cytosine methylation in pig zygotes. The male H3-m(3)K9 pattern is gradually established during pronucleus development, and this process occurs independently of DNA replication. Considering these unique epigenetic features, the pig zygote is, we believe, suited to serve as another model of epigenetic reprogramming that is antithetical to the well-characterized mouse model.

  14. The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy

    Science.gov (United States)

    Aronsen, Jan Magnus; Ferrini, Arianna; Brien, Patrick; Alkass, Kanar; Tomasso, Antonio; Agrawal, Asmita; Bergmann, Olaf; Reik, Wolf; Roderick, Hywel Llewelyn

    2016-01-01

    Cardiac hypertrophic growth in response to pathological cues is associated with reexpression of fetal genes and decreased cardiac function and is often a precursor to heart failure. In contrast, physiologically induced hypertrophy is adaptive, resulting in improved cardiac function. The processes that selectively induce these hypertrophic states are poorly understood. Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which are involved in stable cellular differentiation, specifically in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated these marks with their associated transcriptomes. This analysis revealed the pervasive loss of euchromatic H3K9me2 as a conserved feature of pathological hypertrophy that was associated with reexpression of fetal genes. In hypertrophy, H3K9me2 was reduced following a miR-217–mediated decrease in expression of the H3K9 dimethyltransferases EHMT1 and EHMT2 (EHMT1/2). miR-217–mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy and fetal gene reexpression, while suppression of this pathway protected against pathological hypertrophy both in vitro and in mice. Thus, we have established a conserved mechanism involving a departure of the cardiomyocyte epigenome from its adult cellular identity to a reprogrammed state that is accompanied by reexpression of fetal genes and pathological hypertrophy. These results suggest that targeting miR-217 and EHMT1/2 to prevent H3K9 methylation loss is a viable therapeutic approach for the treatment of heart disease. PMID:27893464

  15. What`s new in federal energy management: FEMP program overview. SAVEnergy program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The SAVEnergy Program provides direct assistance to Federal agencies in identifying and implementing energy efficiency and water conservation measures. The Energy Policy Act of 1992 (EPAct) and Executive Order 12902 require that Federal agencies reduce the energy consumed in Federal buildings. The Executive Order increases the goal to a 30% reduction, compared with 1985, by 2005. In addition, agencies are required, to the maximum extent possible, to install all energy and water conservation measures with paybacks of less than 10 years. To help meet these goals, the US Department of Energy`s (DOE`s) Federal Energy management Program (FEMP) recently initiated the SAVEnergy Program. The SAVEnergy approach has three key elements: The Action Plan with recommended conservation actions and complete proposals on how the agency can implement them; The Action Team to implement the SAVEnergy Action Plan; The FEMPTracks database to evaluate the SAVEnergy Program (and all other FEMP programs) and record progress toward conservation goals.

  16. After the Visit: An Overview of Government and Community Programs Supporting Children with Medical Complexity.

    Science.gov (United States)

    Olson, Kaitlyn B

    2017-05-04

    The optimal care of children with medical complexity (CMC) requires involvement from a network of professionals that includes physicians, nurses, ancillary service providers, and educators. Pediatric health care providers typically have early and frequent contact with the families of CMC. Therefore, they are in a unique position to connect families to developmental, educational, and psychosocial supports. This article reviews important government and community programs that support CMC living in the United States. It outlines the educational rights of children with disabilities and offers practical tips for collaborating with Early Intervention and the public school system. The article also provides an overview of financial assistance programs, respite care services, and support groups that are beneficial to CMC and their families.

  17. After the Visit: An Overview of Government and Community Programs Supporting Children with Medical Complexity

    Directory of Open Access Journals (Sweden)

    Kaitlyn B. Olson

    2017-05-01

    Full Text Available The optimal care of children with medical complexity (CMC requires involvement from a network of professionals that includes physicians, nurses, ancillary service providers, and educators. Pediatric health care providers typically have early and frequent contact with the families of CMC. Therefore, they are in a unique position to connect families to developmental, educational, and psychosocial supports. This article reviews important government and community programs that support CMC living in the United States. It outlines the educational rights of children with disabilities and offers practical tips for collaborating with Early Intervention and the public school system. The article also provides an overview of financial assistance programs, respite care services, and support groups that are beneficial to CMC and their families.

  18. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.

    Directory of Open Access Journals (Sweden)

    Jessica B Bessler

    2010-01-01

    Full Text Available Histone methylation is a prominent feature of eukaryotic chromatin that modulates multiple aspects of chromosome function. Methyl modification can occur on several different amino acid residues and in distinct mono-, di-, and tri-methyl states. However, the interplay among these distinct modification states is not well understood. Here we investigate the relationships between dimethyl and trimethyl modifications on lysine 9 of histone H3 (H3K9me2 and H3K9me3 in the adult Caenorhabditis elegans germ line. Simultaneous immunofluorescence reveals very different temporal/spatial localization patterns for H3K9me2 and H3K9me3. While H3K9me2 is enriched on unpaired sex chromosomes and undergoes dynamic changes as germ cells progress through meiotic prophase, we demonstrate here that H3K9me3 is not enriched on unpaired sex chromosomes and localizes to all chromosomes in all germ cells in adult hermaphrodites and until the primary spermatocyte stage in males. Moreover, high-copy transgene arrays carrying somatic-cell specific promoters are highly enriched for H3K9me3 (but not H3K9me2 and correlate with DAPI-faint chromatin domains. We further demonstrate that the H3K9me2 and H3K9me3 marks are acquired independently. MET-2, a member of the SETDB histone methyltransferase (HMTase family, is required for all detectable germline H3K9me2 but is dispensable for H3K9me3 in adult germ cells. Conversely, we show that the HMTase MES-2, an E(z homolog responsible for H3K27 methylation in adult germ cells, is required for much of the germline H3K9me3 but is dispensable for H3K9me2. Phenotypic analysis of met-2 mutants indicates that MET-2 is nonessential for fertility but inhibits ectopic germ cell proliferation and contributes to the fidelity of chromosome inheritance. Our demonstration of the differential localization and independent acquisition of H3K9me2 and H3K9me3 implies that the trimethyl modification of H3K9 is not built upon the dimethyl modification in

  19. KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation.

    Science.gov (United States)

    Lohmann, Felix; Loureiro, Joseph; Su, Hui; Fang, Qing; Lei, Hong; Lewis, Tanya; Yang, Yi; Labow, Mark; Li, En; Chen, Taiping; Kadam, Shilpa

    2010-02-01

    Dynamic regulation of histone methylation by methyltransferases and demethylases plays a central role in regulating the fate of embryonic stem (ES) cells. The histone H3K9 methyltransferase KMT1E, formerly known as ESET or Setdb1, is essential to embryonic development as the ablation of the Setdb1 gene results in peri-implantation lethality and prevents the propagation of ES cells. However, Setdb1-null blastocysts do not display global changes in H3K9 methylation or DNA methylation, arguing against a genome-wide defect. Here we show that conditional deletion of the Setdb1 gene in ES cells results in the upregulation of lineage differentiation markers, especially trophectoderm-specific factors, similar to effects observed upon loss of Oct3/4 expression in ES cells. We demonstrate that KMT1E deficiency in ES cells leads to a decrease in histone H3K9 methylation at and derepression of trophoblast-associated genes such as Cdx2. Furthermore, we find genes that are derepressed upon Setdb1 deletion to overlap with known targets of polycomb mediated repression, suggesting that KMT1E mediated H3K9 methylation acts in concert with polycomb controlled H3K27 methylation. Our studies thus demonstrate an essential role for KMT1E in the control of developmentally regulated gene expression programs in ES cells.

  20. Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation.

    Science.gov (United States)

    Young, Amy C; Schwarz, Evan; Medina, Genevieve; Obafemi, Adebisi; Feng, Sing-Yi; Kane, Colin; Kleinschmidt, Kurt

    2012-09-01

    Synthetic cannabinoids have been popular recreational drugs of abuse for their psychoactive properties. Five of the many synthetic cannabinoids have been recently banned in the United States because of their unknown and potentially harmful adverse effects. Little is known about these substances. They are thought to have natural cannabinoid-like effects but have different chemical structures. Adverse effects related to synthetic cannabinoids are not well known. We provide clinical effects and patient outcome following K9 use. In addition, we briefly review synthetic cannabinoids. We present a 17-year-old adolescent boy with chest pain, tachycardia, and then bradycardia associated with smoking K9. Two synthetic cannabinoids, JWH-018 and JWH-073, were confirmed on laboratory analysis. In addition to the limited current data, we demonstrate harmful adverse effects related to toxicity of 2 synthetic cannabinoids. Further studies are needed.

  1. 商务大屏 双网双待 中恒K9

    Institute of Scientific and Technical Information of China (English)

    GWY

    2012-01-01

    一直主推商务手机的中恒,在功能上采用逐步升级的策略,以此满足不同层次用户的需要。K9从型号上来看是K8的延续,两者均强调双网双待,后者支持GSM/WCDMA,后者则支持GSM/CDMA2000。因此从功能上来看,K9也可以看作是SX30+的大屏升级版。

  2. Heterochromatic genome stability requires regulators of histone H3 K9 methylation.

    Directory of Open Access Journals (Sweden)

    Jamy C Peng

    2009-03-01

    Full Text Available Heterochromatin contains many repetitive DNA elements and few protein-encoding genes, yet it is essential for chromosome organization and inheritance. Here, we show that Drosophila that lack the Su(var3-9 H3K9 methyltransferase display significantly elevated frequencies of spontaneous DNA damage in heterochromatin, in both somatic and germ-line cells. Accumulated DNA damage in these mutants correlates with chromosomal defects, such as translocations and loss of heterozygosity. DNA repair and mitotic checkpoints are also activated in mutant animals and are required for their viability. Similar effects of lower magnitude were observed in animals that lack the RNA interference pathway component Dcr2. These results suggest that the H3K9 methylation and RNAi pathways ensure heterochromatin stability.

  3. Heterochromatic genome stability requires regulators of histone H3 K9 methylation.

    Science.gov (United States)

    Peng, Jamy C; Karpen, Gary H

    2009-03-01

    Heterochromatin contains many repetitive DNA elements and few protein-encoding genes, yet it is essential for chromosome organization and inheritance. Here, we show that Drosophila that lack the Su(var)3-9 H3K9 methyltransferase display significantly elevated frequencies of spontaneous DNA damage in heterochromatin, in both somatic and germ-line cells. Accumulated DNA damage in these mutants correlates with chromosomal defects, such as translocations and loss of heterozygosity. DNA repair and mitotic checkpoints are also activated in mutant animals and are required for their viability. Similar effects of lower magnitude were observed in animals that lack the RNA interference pathway component Dcr2. These results suggest that the H3K9 methylation and RNAi pathways ensure heterochromatin stability.

  4. Acupuncture promotes angiogenesis after myocardial ischemia through H3K9 acetylation regulation at VEGF gene.

    Directory of Open Access Journals (Sweden)

    Shu-Ping Fu

    Full Text Available BACKGROUND: Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI, but the mechanisms have not yet been well elucidated. Angiogenesis mediated by VEGF gene expression and its modification through histone acetylation has been considered a target in treating myocardial ischemia. This study aims to exam whether modulation of angiogenesis through H3K9 acetylation regulation at VEGF gene is one possible cardioprotective mechanism of acupuncture. RESULTS: We generated rat MI models by ligating the left anterior descending coronary artery and applied electroacupuncture (EA treatment at the Neiguan (PC6 acupoint. Our results showed that acupuncture reversed the S-T segment change, reduced Q-wave area, decreased CK, CK-MB, LDH levels, mitigated myocardial remodeling, and promoted microvessel formation in the MI heart. RNA-seq analysis showed that VEGF-induced angiogenesis signaling was involved in the modulation of EA. Western blot results verified that the protein expressions of VEGF, Ras, phospho-p44/42 MAPK, phospho-p38 MAPK, phospho-SAPK/JNK and Akt, were all elevated significantly by EA treatment in the MI heart. Furthermore, increased H3K9 acetylation was also observed according with the VEGF. ChIP assay confirmed that EA treatment could notably stimulate the recruitment of H3K9ace at the VEGF promoter. CONCLUSIONS: Our study demonstrates for the first time that acupuncture can effectively up-regulate VEGF expression through H3K9 acetylation modification directly at the VEGF promoter and hence activate VEGF-induced angiogenesis in rat MI models. We employed high throughput sequencing in this study and, for the first time, generated genome-wide gene expression profiles both in the rat MI model and in acupuncture treatment.

  5. Acupuncture promotes angiogenesis after myocardial ischemia through H3K9 acetylation regulation at VEGF gene.

    Science.gov (United States)

    Fu, Shu-Ping; He, Su-Yun; Xu, Bin; Hu, Chen-Jun; Lu, Sheng-Feng; Shen, Wei-Xing; Huang, Yan; Hong, Hao; Li, Qian; Wang, Ning; Liu, Xuan-Liang; Liang, Fanrong; Zhu, Bing-Mei

    2014-01-01

    Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI), but the mechanisms have not yet been well elucidated. Angiogenesis mediated by VEGF gene expression and its modification through histone acetylation has been considered a target in treating myocardial ischemia. This study aims to exam whether modulation of angiogenesis through H3K9 acetylation regulation at VEGF gene is one possible cardioprotective mechanism of acupuncture. We generated rat MI models by ligating the left anterior descending coronary artery and applied electroacupuncture (EA) treatment at the Neiguan (PC6) acupoint. Our results showed that acupuncture reversed the S-T segment change, reduced Q-wave area, decreased CK, CK-MB, LDH levels, mitigated myocardial remodeling, and promoted microvessel formation in the MI heart. RNA-seq analysis showed that VEGF-induced angiogenesis signaling was involved in the modulation of EA. Western blot results verified that the protein expressions of VEGF, Ras, phospho-p44/42 MAPK, phospho-p38 MAPK, phospho-SAPK/JNK and Akt, were all elevated significantly by EA treatment in the MI heart. Furthermore, increased H3K9 acetylation was also observed according with the VEGF. ChIP assay confirmed that EA treatment could notably stimulate the recruitment of H3K9ace at the VEGF promoter. Our study demonstrates for the first time that acupuncture can effectively up-regulate VEGF expression through H3K9 acetylation modification directly at the VEGF promoter and hence activate VEGF-induced angiogenesis in rat MI models. We employed high throughput sequencing in this study and, for the first time, generated genome-wide gene expression profiles both in the rat MI model and in acupuncture treatment.

  6. The North American Regional Climate Change Assessment Program: Overview of Climate Change Results

    Science.gov (United States)

    Mearns, L. O.

    2012-12-01

    The North American Regional Climate Change Assessment Program (NARCCAP) is an international program that is serving the climate scenario needs of the United States, Canada, and northern Mexico. We are systematically investigating the uncertainties in regional scale projections of future climate and producing high resolution climate change scenarios using multiple regional climate models (RCMs) and multiple global model responses by nesting the RCMs within atmosphere ocean general circulation models (AOGCMs) forced with a medium-high emissions scenario, over a domain covering the conterminous US, northern Mexico, and most of Canada. The project also includes a validation component through nesting the participating RCMs within the NCEP reanalysis R2. The basic spatial resolution of the RCM simulations is 50 km. This program includes six different RCMs that have been used in various intercomparison programs in Europe and the United States. Four different AOGCMs provide boundary conditions to drive the RCMS for 30 years in the current climate and 30 years for the mid 21st century. The resulting climate model simulations form the basis for multiple high resolution climate scenarios that can be used in climate change impacts and adaptation assessments over North America. All 12 sets of current and future simulations have been completed. Measures of uncertainty across the multiple simulations are being developed by geophysical statisticians. In this overview talk, results from the various climate change experiments for various subregions, along with measures of uncertainty, will be presented

  7. The DOE Office of Environmental Management International Collaboration Program Overview: Interactions, Agreements, and Future Direction

    Energy Technology Data Exchange (ETDEWEB)

    Marra, James C.; Fox, Kevin M.; Jannik, Gerald T.; Farfan, Eduardo B.; Kim, Dong-Sang; Vienna, John D.; Roach, Jay; Aloy, A. S.; Stefanovsky, S. V.; Lopukh, D. B.; Bondarkov, M. D.; Gerdes, Kurt D.; Han, Ana M.

    2010-02-10

    As the lead U.S. agency for the environmental cleanup, the Department of Energy (DOE) Office of Environmental Management (EM) carries out international activities in support of U.S. policies and objectives regarding accelerated risk reduction and remediation of the environmental legacy of the nation's nuclear weapons program and government-sponsored nuclear energy research. To achieve this, EM pursues collaborations with foreign government organizations, educational institutions, and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. An initiative of the International Program is to link international experience and expertise to the technical needs of the overall EM mission and to foster further collaboration with international partners to promote those needs. This paper will provide an overview of the current international program and how it plans to leverage existing, and when necessary, new international partnerships to support the overall EM cleanup mission. In addition it will examine the future vision of the international program to promote the EM mission through a focus on transformational solutions, science, and technology development.

  8. Study on Dynamic Compression Properties of K9 Glass with Doppler Pins Array Measurements

    Science.gov (United States)

    Changming, Hu; Xiang, Wang; Lingcang, Cai; Cangli, Liu

    2009-06-01

    K9 glass is one of archetypal brittle materials for studies of dynamic fracture, failure wave, and so on. This paper presented the dynamic compression properties of K9 glass under uniaxial strain condition. Experimental sample is K9 glass with internal pre-existed defects, and the shape of pre-existed defects is disc with less than 0.5 mm diameter. All tests were conducted by power gun with 37 mm diameter chamber. Doppler Pins array with high space-time resolutions, which consists of sixteen pins in range of 2 mm line length, were applied to measure the particle velocity histories in different positions at the sample rear surface, and the space-resolution is 127 μm, Experimental results show failure waves initiate at internal micro-surfaces of the sample under shock loading, and the dynamic stress concentration is likely attributed to be a physical mechanism of the initiation of the failure wave. These defects that by the controlled laser irradiation in advance are some internal micro-surfaces. Meanwhile, the experimental results show that internal micro-surfaces of the sample have influence on the elastic precursor wave decay.

  9. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

    Science.gov (United States)

    Ryu, Hoon; Lee, Junghee; Hagerty, Sean W; Soh, Byoung Yul; McAlpin, Sara E; Cormier, Kerry A; Smith, Karen M; Ferrante, Robert J

    2006-12-12

    Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. It has been suggested that altered chromatin modulation and transcription dysfunction may play a role in the pathogenesis of Huntington's disease (HD). Increased histone methylation, a well established mechanism of gene silencing, results in transcriptional repression. ERG-associated protein with SET domain (ESET), a histone H3 (K9) methyltransferase, mediates histone methylation. We show that ESET expression is markedly increased in HD patients and in transgenic R6/2 HD mice. Similarly, the protein level of trimethylated histone H3 (K9) was also elevated in HD patients and in R6/2 mice. We further demonstrate that both specificity protein 1 (Sp1) and specificity protein 3 (Sp3) act as transcriptional activators of the ESET promoter in neurons and that mithramycin, a clinically approved guanosine-cytosine-rich DNA binding antitumor antibiotic, interferes with the DNA binding of these Sp family transcription factors, suppressing basal ESET promoter activity in a dose dependent manner. The combined pharmacological treatment with mithramycin and cystamine down-regulates ESET gene expression and reduces hypertrimethylation of histone H3 (K9). This polytherapy significantly ameliorated the behavioral and neuropathological phenotype in the R6/2 mice and extended survival over 40%, well beyond any existing reported treatment in HD mice. Our data suggest that modulation of gene silencing mechanisms, through regulation of the ESET gene is important to neuronal survival and, as such, may be a promising treatment in HD patients.

  10. Optical properties of K9 glass waveguides fabricated by using carbon-ion implantation

    Science.gov (United States)

    Liu, Chun-Xiao; Wei, Wei; Fu, Li-Li; Zhu, Xu-Feng; Guo, Hai-Tao; Li, Wei-Nan; Lin, She-Bao

    2016-07-01

    K9 glass is a material with promising properties that make it attractive for optical devices. Ion implantation is a powerful technique to form waveguides with controllable depth and refractive index profile. In this work, optical planar waveguide structures were fabricated in K9 glasses by using 6.0-MeV C3+-ion implantation with a fluence of 1.0 × 1015 ions/cm2. The effective refractive indices of the guided modes were measured by using a prism-coupling system. The refractive index change in the ion-irradiated region was simulated by using the intensity calculation method. The modal intensity profile of the waveguide was calculated and measured by using the finite difference beam propagation method and the end-face coupling technique, respectively. The transmission spectra before and after the implantation showed that the main absorption band was not influenced by the low fluence dopants. The optical properties of the carbon-implanted K9 glass waveguides show promise for use as integrated photonic devices.

  11. File list: His.PSC.20.H3K9ac.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.H3K9ac.AllCell mm9 Histone H3K9ac Pluripotent stem cell SRX185844,SRX185...848,SRX873351,SRX873349,SRX873345,SRX097641,SRX130021,SRX873347,SRX187620 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.H3K9ac.AllCell.bed ...

  12. Histone H3-K9 methyltransferase ESET is essential for early development.

    Science.gov (United States)

    Dodge, Jonathan E; Kang, Yong-Kook; Beppu, Hideyuki; Lei, Hong; Li, En

    2004-03-01

    Methylation of histone H3 at lysine 9 (H3-K9) mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing gene expression at euchromatic sites. ESET, G9a, SUV39-h1, SUV39-h2, and Eu-HMTase are histone methyltransferases that catalyze H3-K9 methylation in mammalian cells. Previous studies demonstrate that the SUV39-h proteins are preferentially targeted to the pericentric heterochromatin, and mice lacking both Suv39-h genes show cytogenetic abnormalities and an increased incidence of lymphoma. G9a methylates H3-K9 in euchromatin, and G9a null embryos die at 8.5 days postcoitum (dpc). G9a null embryo stem (ES) cells show altered DNA methylation in the Prader-Willi imprinted region and ectopic expression of the Mage genes. So far, an Eu-HMTase mouse knockout has not been reported. ESET catalyzes methylation of H3-K9 and localizes mainly in euchromatin. To investigate the in vivo function of Eset, we have generated an allele that lacks the entire pre- and post-SET domains and that expresses lacZ under the endogenous regulation of the Eset gene. We found that zygotic Eset expression begins at the blastocyst stage and is ubiquitous during postimplantation mouse development, while the maternal Eset transcripts are present in oocytes and persist throughout preimplantation development. The homozygous mutations of Eset resulted in peri-implantation lethality between 3.5 and 5.5 dpc. Blastocysts null for Eset were recovered but in less than Mendelian ratios. Upon culturing, 18 of 24 Eset(-/-) blastocysts showed defective growth of the inner cell mass and, in contrast to the approximately 65% recovery of wild-type and Eset(+/-) ES cells, no Eset(-/-) ES cell lines were obtained. Global H3-K9 trimethylation and DNA methylation at IAP repeats in Eset(-/-) blastocyst outgrowths were not dramatically altered. Together, these results suggest that Eset is required for peri-implantation development and the survival of ES cells.

  13. Early Childhood Caries and the Impact of Current U.S. Medicaid Program: An Overview

    Directory of Open Access Journals (Sweden)

    Bussma Ahmed Bugis

    2012-01-01

    Full Text Available Pediatric dental caries is the most common chronic disease among children. Above 40% of the U.S. children aged 2–11 years have dental caries; more than 50% of them come from low-income families. Under dental services of the Medicaid program, children enrolled in Medicaid must receive preventive dental services. However, only 1/5 of them utilize preventive dental services. The purpose of this overview is to measure the impact of Medicaid dental benefits on reducing oral health disparities among Medicaid-eligible children. This paper explains the importance of preventive dental care, children at high risk of dental caries, Medicaid dental benefits, utilization of dental preventive services by Medicaid-eligible children, dental utilization influencing factors, and outcome evaluation of Medicaid in preventing dental caries among children. In conclusion, despite the recent increase of children enrolled in Medicaid, utilizing preventive dental care is still a real challenge that faces Medicaid.

  14. Telecommunications, navigation and information management concept overview for the Space Exploration Initiative program

    Science.gov (United States)

    Bell, Jerome A.; Stephens, Elaine; Barton, Gregg

    1991-01-01

    An overview is provided of the Space Exploration Initiative (SEI) concepts for telecommunications, information systems, and navigation (TISN), and engineering and architecture issues are discussed. The SEI program data system is reviewed to identify mission TISN interfaces, and reference TISN concepts are described for nominal, degraded, and mission-critical data services. The infrastructures reviewed include telecommunications for robotics support, autonomous navigation without earth-based support, and information networks for tracking and data acquisition. Four options for TISN support architectures are examined which relate to unique SEI exploration strategies. Detailed support estimates are given for: (1) a manned stay on Mars; (2) permanent lunar and Martian settlements; short-duration missions; and (4) systematic exploration of the moon and Mars.

  15. Overview of the US Department of Energy Light Water Reactor Sustainability Program

    Energy Technology Data Exchange (ETDEWEB)

    K. A. McCarthy; D. L. Williams; R. Reister

    2012-05-01

    The US Department of Energy Light Water Reactor Sustainability Program is focused on the long-term operation of US commercial power plants. It encompasses two facets of long-term operation: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the nuclear industry that support implementation of performance improvement technologies. An important aspect of the Light Water Reactor Sustainability Program is partnering with industry and the Nuclear Regulatory Commission to support and conduct the long-term research needed to inform major component refurbishment and replacement strategies, performance enhancements, plant license extensions, and age-related regulatory oversight decisions. The Department of Energy research, development, and demonstration role focuses on aging phenomena and issues that require long-term research and/or unique Department of Energy laboratory expertise and facilities and are applicable to all operating reactors. This paper gives an overview of the Department of Energy Light Water Reactor Sustainability Program, including vision, goals, and major deliverables.

  16. DNA methylation and histone H3-K9 modifications contribute to MUC17 expression.

    Science.gov (United States)

    Kitamoto, Sho; Yamada, Norishige; Yokoyama, Seiya; Houjou, Izumi; Higashi, Michiyo; Goto, Masamichi; Batra, Surinder K; Yonezawa, Suguru

    2011-02-01

    MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract. It has been suggested that MUC17 expression is correlated with the malignancy potential of pancreatic ductal adenocarcinomas (PDACs). In the present study, we provided the first report of the MUC17 gene expression through epigenetic regulation such as promoter methylation, histone modification and microRNA (miRNA) expression. Near the transcriptional start site, the DNA methylation level of MUC17-negative cancer cell lines (e.g. PANC1) was high, whereas that of MUC17-positive cells (e.g. AsPC-1) was low. Histone H3-K9 (H3-K9) modification status was also closely related to MUC17 expression. Our results indicate that DNA methylation and histone H3-K9 modification in the 5' flanking region play a critical role in MUC17 expression. Furthermore, the hypomethylation status was observed in patients with PDAC. This indicates that the hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of PDAC. In addition, the result of miRNA microarray analysis showed that five potential miRNA candidates existed. It is also possible that the MUC17 might be post-transcriptionally regulated by miRNA targeting to the 3'-untranslated region of its mRNA. These understandings of the epigenetic changes of MUC17 may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients.

  17. The National Shipbuilding Research Program, Proceedings of the REAPS Technical Symposium Paper No. 1: Ship Production Committee Panel Overviews

    Science.gov (United States)

    1980-10-01

    consensus specification, we experienced sematical problems. Avondale Shipyards, Inc. requested Mr. Richard Muther , President of Richard Muther and...1978, Mr. Richard Muther addressed the panel. His primary objective was definition which would do away with the sematical problems. Mr. Richard Muther’s...COMMITTEE PANEL OVERVIEWS SP-1 - SHIPYARD FACILITIES AND ENVIRONMENTAL EFFECTS Richard A. Price Program Manager Maritime Administration Research and

  18. Study on dynamic compression performance of K9 glass with prefabricated defects

    Science.gov (United States)

    Hu, Changming; Wang, Xiang; Cai, Lingcang; Liu, Cangli

    2012-03-01

    We conducted several planar impact experiments to study dynamic compression properties of K9 glass on powder gun using Photon Doppler Velocimetry (PDV) measure system. Samples are prefabricated some internal meso-defects by laser three-dimensional erosion technique before shock loading. Free surface velocities recorded by high temporal-spatial resolution PDV array or multi-point PDV. All these experimental results show some different properties influenced by evolutions of pre-existed internal defects face on free surface velocity profiles. The critical compression strength and dynamic evolution information of pre-existed internal defects can be derived from the experimental results tentatively.

  19. Fast Predicting Statistical Subsurface Damage Parameters of the K9 Sample

    Science.gov (United States)

    Wang, Hairong; Chen, Hongfeng; Xiao, Lihui; Zhang, Bike; Jiang, Zhuangde

    2015-07-01

    Based on the subsurface damage model and the material removal rate of K9 glass in HF acid solution, a fast method is proposed to calculate the parameters of characterizing the subsurface damage of a polished sample. When micro cracks of the etched sample's subsurface can be clearly observed, lengths, widths, angles, densities of the micro cracks can be calculated by using the image processing algorithm, and depths of the micro cracks may be predicted by the load-crack model. Eventually a set of the parameters are proposed as a complete description about subsurface damage of the sample.

  20. Evaluación cardiovascular en perros de atención inmediata (k9)

    OpenAIRE

    Julio Adrián Benítez Tezoquipa; Roberto Villa Ocaranza; Alejandro Rodolfo Reynoso Palomar

    2012-01-01

    El estudio de las respuestas al ejercicio y entrenamiento tipo K9 en perros, ha sido poco evaluado a diferencia de otros tipos de entrenamiento en deportes o utilidades en canidos. El ejercicio continuo y el entrenamiento exhaustivo conducen al desgaste físico y emocional de los perros, por lo que realizar la valoración del sistema cardiovascular permitió determinar el tipo, características y posibles factores involucrados en el desarrollo de cardiopatías en este tipo de animales. Se efectuar...

  1. A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

    Energy Technology Data Exchange (ETDEWEB)

    Shan, Chun-Min; Wang, Jiyong; Xu, Ke; Chen, Huijie; Yue, Jia-Xing; Andrews, Stuart; Moresco, James J.; Yates, John R.; Nagy, Peter L.; Tong, Liang; Jia, Songtao

    2016-09-20

    Histone lysine-to-methionine (K-to-M) mutations are associated with multiple cancers, and they function in a dominant fashion to block the methylation of corresponding lysines on wild type histones. However, their mechanisms of function are controversial. Here we show that in fission yeast, introducing the K9M mutation into one of the three histone H3 genes dominantly blocks H3K9 methylation on wild type H3 across the genome. In addition, H3K9M enhances the interaction of histone H3 tail with the H3K9 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 is trapped at nucleation sites to prevent its spreading and the formation of large heterochromatin domains. We further determined the crystal structure of an H3K9M peptide in complex with human H3K9 methyltransferase G9a and SAM, which reveales that the methionine side chain had enhanced van der Waals interactions with G9a. Therefore, our results provide a detailed mechanism by which H3K9M regulates H3K9 methylation.

  2. 固结磨料化学机械研抛K9玻璃的材料去除机理%Material Removal Mechanism of K9 Glass During Chemical Mechanical Polishing by Fixed Abrasive Pad

    Institute of Scientific and Technical Information of China (English)

    樊吉龙; 朱永伟; 李军; 叶剑锋

    2012-01-01

    采用失重法对固结磨料研抛K9玻璃材料去除过程中的机械与化学作用进行了分离,采用显微硬度方法分析了研抛液对K9玻璃工件表层硬度的影响.研究结果表明:研抛液能与K9玻璃发生化学反应并在其表面形成一层较基质材料软的变质层,变质层厚度随浸泡时间的延长而增加;单纯研抛液的化学作用对K9玻璃的材料去除作用有限,固结磨料研抛垫对K9玻璃的机械去除作用主要以脆性去除为主,化学与机械的交互作用是K9玻璃影响材料去除的主要方式:当研抛盘转速为200r/min时,化学作用与机械作用达到平衡,交互作用最为强烈,材料去除率达到最大值.%The mechanical and chemical functions during the material removal process are separated by adopting weight loss measurements when fixed abrasive pad works on K9 glass. The influence of polishing slurry on the surface hardness of K9 glass is also analyzed by the micro-hardness method. The research results show that the chemical reaction between polishing slurry and K9 glass will take place and form a denatured layer on the surface of K9 glass, which is softer than host material and whose thickness increases with soak time. The material removal rate of K9 glass by chemical function is very limited and the mechanical function of K9 glass is mainly by brittle removal, while the interaction of chemical and mechanical functions is the main factor in influencing the material removal rate of K9 glass. When the rotation speed of the polishing pad is 200 r/min, the chemical and mechanical functions come to a balance with their interaction being the strongest, and the material removal rate reaches its maximum.

  3. The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression.

    Science.gov (United States)

    Yang, Yong-Jin; Han, Jeung-Whan; Youn, Hong-Duk; Cho, Eun-Jung

    2010-01-01

    Parafibromin, a component of the RNA polymerase II-associated PAF1 complex, is a tumor suppressor linked to hyperparathyroidism-jaw tumor syndrome and sporadic parathyroid carcinoma. Parafibromin induces cell cycle arrest by repressing cyclin D1 via an unknown mechanism. Here, we show that parafibromin interacts with the histone methyltransferase, SUV39H1, and functions as a transcriptional repressor. The central region (128-227 amino acids) of parafibromin is important for both the interaction with SUV39H1 and transcriptional repression. Parafibromin associated with the promoter and coding regions of cyclin D1 and was required for the recruitment of SUV39H1 and the induction of H3 K9 methylation but not H3 K4 methylation. RNA interference analysis showed that SUV39H1 was critical for cyclin D1 repression. These data suggest that parafibromin plays an unexpected role as a repressor in addition to its widely known activity associated with transcriptional activation. Parafibromin as a part of the PAF1 complex might downregulate cyclin D1 expression by integrating repressive H3 K9 methylation during transcription.

  4. K9玻璃的离子束抛光

    Institute of Scientific and Technical Information of China (English)

    苏志伟; 陈庆川

    2005-01-01

    K9玻璃是常用的光学和微系统材料。随着光学和微系统技术的迅速发展,由于具有较低廉的价格、良好的微加工性能,在K9玻璃上制作微米、纳米尺度的微结构和微器件的技术,已应用于光电子、微波技术、衍射光学元件等众多领域。但是,由于光学和微波等器件的表面粗糙可引起光散射和信号损失,从而降低器件性能。因此材料表面的超光滑处理对提高光学和微波等器件的性能具有十分重要的意义。

  5. The North American Regional Climate Change Assessment Program (NARCCAP): Overview of Climate Change Results

    Science.gov (United States)

    Bukovsky, M. S.; Mearns, L. O.

    2012-04-01

    NARCCAP is an international program that is serving the climate scenario needs of the United States, Canada, and northern Mexico. We are systematically investigating the uncertainties in regional scale projections of future climate and producing high resolution climate change scenarios using six different regional climate models (RCMs ) and multiple global model responses to a future emission scenario, by nesting the RCMs within four atmosphere ocean general circulation models (AOGCMs) forced with the A2 SRES scenario, over a domain covering the conterminous US, northern Mexico, and most of Canada. The project also includes a validation component through nesting the participating RCMs within NCEP reanalyses. The spatial resolution of the RCM simulations is 50 km. This program includes RCMs that participated in the European PRUDENCE program (HadRM3 and RegCM), the Canadian regional climate model (CRCM) as well as the NCEP regional spectral model (RSM), the NCAR/PSU MM5, and NCAR WRF. AOGCMs include the Hadley Centre HadCM3, NCAR CCSM, the Canadian CGCM3 and the GFDL model. Insufficient funding was available to simulate all 24 combinations of RCMs and AOGCMs. Thus, we used a balanced fractional factorial statistical design to reduce the number of combinations of RCM-AOGCM pairs to twelve. High resolution (50 km) global time-slice experiments based on the GFDL atmospheric model and the NCAR atmospheric model (CAM3) have also been produced and will be compared with the simulations of the regional models. The geographic domain was regionalized into 29 subregions based on common climatological features, and summary climate change statistics for each of the subregions have been produced. In this overview talk, results from the RCM climate change simulations for select subregions of North America will be presented.

  6. MapGIS K9软件在数字地质图中的应用%DISCUSSION ON THE APPLICATION OF MAPGIS K9 SOFTWARE IN DIGITAL GEOLOGICAL MAPPING

    Institute of Scientific and Technical Information of China (English)

    代丽霞; 胡红霞; 朱忠梅

    2013-01-01

    从制图的角度,结合工作实践阐述了MapGIS K9在地形地质图的绘制、图形数据库的建立等方面的应用.使制图专业人员对MapGIS K9软件更加了解,并对其基本功能与应用由感性上升到理性认识,从而更好地掌握MapGIS K9,提高制图质量及精度要求.

  7. HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Margarida L A Figueiredo

    Full Text Available Heterochromatin protein 1 (HP1 proteins, recognized readers of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me, are important regulators of heterochromatin-mediated gene silencing and chromosome structure. In Drosophila melanogaster three histone lysine methyl transferases (HKMTs are associated with the methylation of H3K9: Su(var3-9, Setdb1, and G9a. To probe the dependence of HP1a binding on H3K9me, its dependence on these three HKMTs, and the division of labor between the HKMTs, we have examined correlations between HP1a binding and H3K9me patterns in wild type and null mutants of these HKMTs. We show here that Su(var3-9 controls H3K9me-dependent binding of HP1a in pericentromeric regions, while Setdb1 controls it in cytological region 2L:31 and (together with POF in chromosome 4. HP1a binds to the promoters and within bodies of active genes in these three regions. More importantly, however, HP1a binding at promoters of active genes is independent of H3K9me and POF. Rather, it is associated with heterochromatin protein 2 (HP2 and open chromatin. Our results support a hypothesis in which HP1a nucleates with high affinity independently of H3K9me in promoters of active genes and then spreads via H3K9 methylation and transient looping contacts with those H3K9me target sites.

  8. Fundamental Aeronautics Program: Overview of Propulsion Work in the Supersonic Cruise Efficiency Technical Challenge

    Science.gov (United States)

    Castner, Ray

    2012-01-01

    The Supersonics Project, part of NASA's Fundamental Aeronautics Program, contains a number of technical challenge areas which include sonic boom community response, airport noise, high altitude emissions, cruise efficiency, light weight durable engines/airframes, and integrated multi-discipline system design. This presentation provides an overview of the current (2012) activities in the supersonic cruise efficiency technical challenge, and is focused specifically on propulsion technologies. The intent is to develop and validate high-performance supersonic inlet and nozzle technologies. Additional work is planned for design and analysis tools for highly-integrated low-noise, low-boom applications. If successful, the payoffs include improved technologies and tools for optimized propulsion systems, propulsion technologies for a minimized sonic boom signature, and a balanced approach to meeting efficiency and community noise goals. In this propulsion area, the work is divided into advanced supersonic inlet concepts, advanced supersonic nozzle concepts, low fidelity computational tool development, high fidelity computational tools, and improved sensors and measurement capability. The current work in each area is summarized.

  9. Fundamental Aeronautics Program: Overview of Project Work in Supersonic Cruise Efficiency

    Science.gov (United States)

    Castner, Raymond

    2011-01-01

    The Supersonics Project, part of NASA?s Fundamental Aeronautics Program, contains a number of technical challenge areas which include sonic boom community response, airport noise, high altitude emissions, cruise efficiency, light weight durable engines/airframes, and integrated multi-discipline system design. This presentation provides an overview of the current (2011) activities in the supersonic cruise efficiency technical challenge, and is focused specifically on propulsion technologies. The intent is to develop and validate high-performance supersonic inlet and nozzle technologies. Additional work is planned for design and analysis tools for highly-integrated low-noise, low-boom applications. If successful, the payoffs include improved technologies and tools for optimized propulsion systems, propulsion technologies for a minimized sonic boom signature, and a balanced approach to meeting efficiency and community noise goals. In this propulsion area, the work is divided into advanced supersonic inlet concepts, advanced supersonic nozzle concepts, low fidelity computational tool development, high fidelity computational tools, and improved sensors and measurement capability. The current work in each area is summarized.

  10. Shellside flow-induced tube vibration in typical heat exchanger configurations: overview of a research program

    Energy Technology Data Exchange (ETDEWEB)

    Halle, H.; Chenoweth, J.M.; Wambsganss, M.W.

    1986-01-01

    A comprehensive research program is being conducted to develop the necessary criteria to assist designers and operators of shell-and-tube heat exchangers to avoid detrimental flow-induced tube vibration. This paper presents an overview of the insights gained from shellside water-flow testing on a horizontal, industrial-sized test exchanger that can be configured in many ways using interchangeable tube bundles and replaceable nozzles. Nearly 50 different configurations have been tested representing various combinations of triangular, square, rotated-triangular, and rotated-square tubefield layouts; odd and even numbers of crosspasses; and both single- and double-segmental baffles with different cut sizes and orientations. The results are generally consistent with analytical relationships that predict tube vibration response by the combined reinforcing effect of the vibration mode shape and flow velocity distribution. An understanding of the vibration and instability performance is facilitated by recognizing that the excitation is induced by three separate, though sometimes interacting, flow conditions. These are the crossflows that generate ''classic'' fluidelastic instabilities in the interior of the tube bundle, the entrance and exit bundle flow from and into the shell nozzles, and the localized high velocity bypass and leakage stream flows. The implications to design and/or possible field remedies to avoid vibration problems are discussed. 17 refs., 10 figs.

  11. The CAM Education Program of the National Center for Complementary and Alternative Medicine: an overview.

    Science.gov (United States)

    Pearson, Nancy J; Chesney, Margaret A

    2007-10-01

    The authors provide a historical context and overview of the experience of education projects at 14 health professions schools in the United States and the American Medical Students Association that were funded by the National Center for Complementary and Alternative Medicine at the National Institutes of Health in cohorts of five per year in 2000, 2001, and 2002-2003. These 15 projects were designed to incorporate CAM information into the curricula of conventional health professions schools. A longer-term goal was to accelerate the integration of CAM and conventional medicine. The overall program started in 2000 at a time when discussions about the definition, goals, and value of integrative medicine were already well underway. The efforts specific to each project, as well as the shared challenges, accomplishments, and collaborative efforts of all 15 projects, can provide guidance for the education of conventional health care providers about CAM in an integrative medicine environment. Challenging issues that must be faced include (1) the need to develop successful strategies to incorporate information about CAM into already dense health professions school curricula, (2) the need for conventional health professionals to have authoritative resources to provide their patients information about risks and benefits of CAM practices, and (3) the need to identify appropriate roles for CAM practitioners in educating conventional health professionals about CAM therapies. The authors discuss these issues and others and present some recommendations.

  12. Commercial Building Energy Asset Score Program Overview and Technical Protocol (Version 1.1)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Goel, Supriya; Makhmalbaf, Atefe

    2013-08-09

    The U.S. Department of Energy (DOE) is developing a voluntary national scoring system for commercial buildings to help building owners and managers assess a building’s energy-related systems independent of operations. The goal of the score is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system, known as the Commercial Building Energy Asset Score, will allow building owners and managers to compare their building infrastructure against peers and track building upgrades over time. The system will also help other building stakeholders (e.g., building investors, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset scoring tool. The alternative methods that were considered prior to developing the current approach are described in the Program Overview and Technical Protocol Version 1.0.

  13. The plasma spectrum research on K9 glass under nanosecond pulse laser%ns脉冲激光作用下K9玻璃的等离子体谱图研究

    Institute of Scientific and Technical Information of China (English)

    刘丽炜; 蔡红星; 李昌立; 何双力; 张喜和; 冯锴

    2008-01-01

    建立一套激光等离子体光谱测量实验装置,以Nd:YAG调Q倍频固体激光器为激发光源,作用K9玻璃.通过对K9的等离子体谱图的分析发现,K9玻璃等离子体谱强度的变化与激光器输出能量呈线性关系.同时利用显微镜观察K9玻璃的表面损伤形貌,并进行理论分析.

  14. Research and Application of Flex Development Mode Based on MapGIS K9 IMS%MapGIS K9 IMS的Flex开发模式研究及应用

    Institute of Scientific and Technical Information of China (English)

    秦超; 姜良君; 薛逸飞; 蔡永香

    2012-01-01

    对MapGIS K9 IMS的Flex开发框架展开研究,重点介绍了Flex客户端的结构及常用的控件,然后结合一个应用实例说明了MapGIS K9 IMS的Flex开发WebGIS的主要过程和关键问题,最后总结了基于MapGIS K9IMS的Flex开发模式设计与开发WebGIS的优势.%This paper introduces the Flex development framework of MapGIS K9 IMS, and mainly discusses the structure of client on Flex and the widgets used frequently. Then, by combining a specific application instance, the paper explains the main process and key problems when developing WebGIS based on this model. At last, the advantages of design and development of WebGIS based on this development mode are summarized

  15. Alignment of palatally impacted canine with open window technique and modified K-9 spring

    Directory of Open Access Journals (Sweden)

    Dipti Shastri

    2014-01-01

    Full Text Available The patient was an 18-year-old female who had an Angle Class I malocclusion with a left palatally impacted maxillary canine. The orthodontic treatment of a palatally impacted canine is aimed at bringing the tooth into its correct position in the dental arch without causing any periodontal damage. To achieve this goal, a variety of surgical and orthodontic techniques have been proposed in relation to the position of the impacted tooth and there are various treatment methods used for traction. The duration of the traction was 3 months and alignment duration was 12 months the total treatment time was 15 months. In the following case, we presented that maxillary palatally impacted canine was brought into the arch with open window method for canine exposure and modified K-9 spring for traction, that is simple spring for orthodontic traction of the palatally impacted canines.

  16. Mapgis k9地籍管理系统测试

    Institute of Scientific and Technical Information of China (English)

    颜循英

    2015-01-01

    由于第二次全国土地调查涉及面广,数据类型多,调查的结果缺乏标准和规范,给政府对全国土地管理带来极大不便,所以全国各省市的土地主管部门对地籍管理系统提出了新的要求。Mapgis k9地籍管理系统软件是按国家规定的制度开发,保证了地籍资料的连贯性、系统性、可靠性、精确性和完整性。

  17. Fuel cell program - Overview reports 2007; Programm Brennstoffzellen inkl. Wasserstoff - Ueberblicksberichte der BFE-Programmleiter 2007

    Energy Technology Data Exchange (ETDEWEB)

    Luzzi, A.; Spirig, M.

    2008-07-01

    This report for the Swiss Federal Office of Energy (SFOE) presents the overview reports made by SFOE Heads of Program on work done in 2007. Projects reported on in the natural gas-fired fuel cell area include the EU-project REAL-SFOC, the long-term testing of anode-supported SOFC stacks, intermediate-temperature fuel cells based on proton conducting electrolytes, the interdisciplinary ONEBAT project and lifetime-enhancement of SOFC stacks for CHP applications. In the polymer-electrolyte fuel cell (PEFC) area, projects concerning proton-conducting polymer membranes, factors limiting the lifetime of fuel cell membranes, a new highly active oxygen reduction electrode for PEM fuel cell and zinc/air battery applications, the enhancement of PEFC durability and reliability, model-based investigation of PEFC performance, and local gas analysis of PE fuel cells are briefly reported on. Long-term research activities in the hydrogen technology area reported on include those concerning the photo-chemical conversion and storage of solar energy and the storage of hydrogen in metallic and complex hydrides. Further projects reported on include those concerning the physical aspects of hydrides for system integration and safety and new, complex metal hydrides. Swiss national and international co-ordination is reviewed in the areas of fuel cell technology and hydrogen technology. Work done in several projects run within the framework of the IEA's Advanced Fuel Cells Program is reviewed. Several pilot and demonstration (P and D) projects are also reported on in the natural-gas SOFC and PEFC areas. Comments on the 2007 results and a review of work to be done in 2008, along with a list of R, D, P and D projects, complete the report.

  18. Overview of space power electronic's technology under the CSTI High Capacity Power Program

    Science.gov (United States)

    Schwarze, Gene E.

    The Civilian Space Technology Initiative (CSTI) is a NASA Program targeted at the development of specific technologies in the areas of transportation, operations and science. Each of these three areas consists of major elements and one of the operation's elements is the High Capacity Power element. The goal of this element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA initiatives. The High Capacity Power element is broken down into several subelements that includes energy conversion in the areas of the free piston Stirling power converter and thermoelectrics, thermal management, power management, system diagnostics, and environmental compatibility and system's lifetime. A recent overview of the CSTI High capacity Power element and a description of each of the program's subelements is given by Winter (1989). The goals of the Power Management subelement are twofold. The first is to develop, test, and demonstrate high temperature, radiation-resistant power and control components and circuits that will be needed in the Power Conditioning, Control and Transmission (PCCT) subsystem of a space nuclear power system. The results obtained under this goal will also be applicable to the instrumentation and control subsystem of a space nuclear reactor. These components and circuits must perform reliably for lifetimes of 7-10 years. The second goal is to develop analytical models for use in computer simulations of candidate PCCT subsystems. Circuits which will be required for a specific PCCT subsystem will be designed and built to demonstrate their performance and, also, to validate the analytical models and simulations. The tasks under the Power Management subelement will now be described in terms of objectives, approach and present status of work.

  19. Overview of space power electronic's technology under the CSTI High Capacity Power Program

    Science.gov (United States)

    Schwarze, Gene E.

    1994-01-01

    The Civilian Space Technology Initiative (CSTI) is a NASA Program targeted at the development of specific technologies in the areas of transportation, operations and science. Each of these three areas consists of major elements and one of the operation's elements is the High Capacity Power element. The goal of this element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA initiatives. The High Capacity Power element is broken down into several subelements that includes energy conversion in the areas of the free piston Stirling power converter and thermoelectrics, thermal management, power management, system diagnostics, and environmental compatibility and system's lifetime. A recent overview of the CSTI High capacity Power element and a description of each of the program's subelements is given by Winter (1989). The goals of the Power Management subelement are twofold. The first is to develop, test, and demonstrate high temperature, radiation-resistant power and control components and circuits that will be needed in the Power Conditioning, Control and Transmission (PCCT) subsystem of a space nuclear power system. The results obtained under this goal will also be applicable to the instrumentation and control subsystem of a space nuclear reactor. These components and circuits must perform reliably for lifetimes of 7-10 years. The second goal is to develop analytical models for use in computer simulations of candidate PCCT subsystems. Circuits which will be required for a specific PCCT subsystem will be designed and built to demonstrate their performance and, also, to validate the analytical models and simulations. The tasks under the Power Management subelement will now be described in terms of objectives, approach and present status of work.

  20. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway.

    Science.gov (United States)

    Gao, S J; Boshoff, C; Jayachandra, S; Weiss, R A; Chang, Y; Moore, P S

    1997-10-16

    Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus linked to the development of Kaposi's sarcoma and a rare B cell lymphoma, primary effusion lymphoma. The KSHV gene ORF K9 encodes vIRF which is a protein with low but significant homology to members of the interferon (IFN) regulatory factor (IRF) family responsible for regulating intracellular interferon signal transduction (Moore PS, Boshoff C, Weiss RA and Chang Y. (1996). Science, 274, 1739-1744). vIRF inhibits IFN-beta signal transduction as measured using an IFN-responsive ISG54 reporter construct co-transfected with ORF K9 into HeLa and 293 cells. vIRF also suppresses genes under IFN regulatory control as shown by inhibition of the IFN-beta inducibility of p21WAF1/CIP1, however, no direct DNA-binding or protein-protein interactions characteristic for IRF repressor proteins were identified. Stable transfectant NIH3T3 clones expressing vIRF grew in soft agar and at low serum concentrations, lost contact inhibition and formed tumors after injection into nude mice indicating that vIRF has the properties of a viral oncogene. Since vIRF is primarily expressed in KSHV-infected B cells, not KS spindle cells, this study suggests that vIRF is a transforming oncogene active in B cell neoplasias that may provide a unique immune escape mechanism for infected cells. This data is consistent with tumor suppressor pathways serving a dual function as host cell antiviral pathways.

  1. Study on ultra-precision machining of K9 glass by fixed abrasive lapping and polishing%固结磨料研磨抛光K9玻璃的超精密加工工艺研究

    Institute of Scientific and Technical Information of China (English)

    李标; 李军; 朱永伟; 夏磊; 李鹏鹏; 孙玉利; 左敦稳

    2012-01-01

    PHL-350 High-speed lapping & polishing system was employed in ultra-precision machining experiment of K9 glass by fixed abrasive lapping and polishing. Influence of fixed abrasive pad ( FAP ) with different particle size and different abrasive on material removal rate and surface quality of the K9 glass was studied. An ultra-precision machining process of K9 glass with high efficiency, low cost and high quality was obtained: first M20/30 diamond FAP was used for lapping, then 3 μm CeO2 FAP was used for polishing. A good surface of K9 glass with surface roughness RMS less than 0. 6 nm and very few micro scratches or damages was achieved.%采用PHL-350型平面高速研磨抛光系统,通过固结磨料研磨抛光方法进行了超精密加工K9玻璃试验研究.探讨了不同粒径和不同磨粒研磨抛光垫在加工中对K9玻璃材料去除率和表面质量的影响.获得了高效率、低成本、高质量的K9玻璃的超精密加工工艺:首先使用M20/30金刚石研磨垫研磨,然后使用3μm CeO2抛光垫抛光.加工后K9玻璃的表面粗糙度优于RMS 0.6 nm,微观损伤少.

  2. Analysis of gene selection in reassortant formation between canine rotavirus K9 and human rotaviruses with different antigenic specificities.

    Science.gov (United States)

    Kobayashi, N; Taniguchi, K; Urasawa, T; Urasawa, S

    1993-01-01

    A number of antigenic mosaic reassortants which have neutralization proteins VP4 and VP7 derived from different parental strains were analysed in order to study gene selection in reassortant formation between animal and human rotaviruses (HRV). These reassortants were isolated from mixed infection of MA-104 cells with canine rotavirus strain K9 (subgroup I and G serotype 3) and HRV strains (with subgroup I or II antigen and G serotype 1-4, 9 or 12 antigen), through repeated selections with anti-VP4 and anti-VP7 neutralizing monoclonal antibodies directed specifically at HRV and K9, respectively. By serological and genomic analyses, all the isolated clones were found to be antigenic mosaic reassortants possessing VP4 of K9 and VP7 of HRV. In the reassortants between strain K9 and one of the six strains of subgroup II HRV, a single or a few genotypes with particular constellations of RNA segments were predominant, with only a few RNA segments including gene 4 (encoding VP4) being derived from K9. In contrast, in the reassortants between strain K9 and any one of the subgroup I HRV, more than nine different genotypes were identified and various RNA segments, except for segments 8 and 10, were derived from K9. These findings indicated that the RNA segments of K9 might be reassorted more readily with those of subgroup I HRV than with those of subgroup II HRV, suggesting the possible existence of functional mechanisms which determine the extent of diversity of genome selection depending on the pairs of parent strains in the reassortant formation.

  3. Target Salt 2025: A Global Overview of National Programs to Encourage the Food Industry to Reduce Salt in Foods

    OpenAIRE

    Jacqui Webster; Kathy Trieu; Elizabeth Dunford; Corinna Hawkes

    2014-01-01

    Reducing population salt intake has been identified as a priority intervention to reduce non-communicable diseases. Member States of the World Health Organization have agreed to a global target of a 30% reduction in salt intake by 2025. In countries where most salt consumed is from processed foods, programs to engage the food industry to reduce salt in products are being developed. This paper provides a comprehensive overview of national initiatives to encourage the food industry to reduce sa...

  4. Overview and current status of DOE/UPVG`s TEAM-UP Program

    Energy Technology Data Exchange (ETDEWEB)

    Hester, S.

    1995-11-01

    An overview is given of the Utility Photovoltaic Group. The mission is to accelerate the use of small-scale and large scale applications of photovoltaics for the benefit of the electric utilities and their customers.

  5. OVERVIEW OF RECENT EXPERIMENTAL RESULTS FROM THE DIII-D ADVANCED TOKAMAK PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    BURRELL,KH

    2002-11-01

    OAK A271 OVERVIEW OF RECENT EXPERIMENTAL RESULTS FROM THE DIII-D ADVANCED TOKAMAK PROGRAM. The DIII-D research program is developing the scientific basis for advanced tokamak (AT) modes of operation in order to enhance the attractiveness of the tokamak as an energy producing system. Since the last International Atomic Energy Agency (IAEA) meeting, the authors have made significant progress in developing the building blocks needed for AT operation: (1) the authors have doubled the magnetohydrodynamic (MHD) stable tokamak operating space through rotational stabilization of the resistive wall mode; (2) using this rotational stabilization, they have achieved {beta}{sub N}H{sub 89} {le} 10 for 4 {tau}{sub E} limited by the neoclassical tearing mode; (3) using real-time feedback of the electron cyclotron current drive (ECCD) location, they have stabilized the (m,n) = (3,2) neoclassical tearing mode and then increased {beta}{sub T} by 60%; (4) they have produced ECCD stabilization of the (2,1) neoclassical tearing mode in initial experiments; (5) they have made the first integrated AT demonstration discharges with current profile control using ECCD; (6) ECCD and electron cyclotron heating (ECH) have been used to control the pressure profile in high performance plasmas; and (7) they have demonstrated stationary tokamak operation for 6.5 s (36 {tau}{sub E}) at the same fusion gain parameter of {beta}{sub N}H{sub 89}/q{sub 95}{sup 2} {approx} 0.4 as ITER but at much higher q{sub 95} = 4.2. They have developed general improvements applicable to conventional and advanced tokamak operating modes: (1) they have an existence proof of a mode of tokamak operation, quiescent H-mode, which has no pulsed, ELM heat load to the divertor and which can run for long periods of time (3.8 s or 25 {tau}{sub E}) with constant density and constant radiation power; (2) they have demonstrated real-time disruption detection and mitigation for vertical disruption events using high pressure gas jet

  6. The Cryogenic AntiCoincidence detector for ATHENA X-IFU: a program overview

    Science.gov (United States)

    Macculi, C.; Argan, A.; D'Andrea, M.; Lotti, S.; Laurenza, M.; Piro, L.; Biasotti, M.; Corsini, D.; Gatti, F.; Torrioli, G.; Fiorini, M.; Molendi, S.; Uslenghi, M.; Mineo, T.; Bulgarelli, A.; Fioretti, V.; Cavazzuti, E.

    2016-07-01

    The ATHENA observatory is the second large-class ESA mission, in the context of the Cosmic Vision 2015 - 2025, scheduled to be launched on 2028 at L2 orbit. One of the two on-board instruments is the X-IFU (X-ray Integral Field Unit): it is a TES-based kilo-pixels order array able to perform simultaneous high-grade energy spectroscopy (2.5 eV at 6 keV) and imaging over the 5 arcmin FoV. The X-IFU sensitivity is degraded by the particles background which is induced by primary protons of both solar and Cosmic Rays origin, and secondary electrons. The studies performed by Geant4 simulations depict a scenario where it is mandatory the use of reduction techniques that combine an active anticoincidence detector and a passive electron shielding to reduce the background expected in L2 orbit down to the goal level of 0.005 cts/cm2/s/keV, so enabling the characterization of faint or diffuse sources (e.g. WHIM or Galaxy cluster outskirts). From the detector point of view this is possible by adopting a Cryogenic AntiCoincidence (CryoAC) placed within a proper optimized environment surrounding the X-IFU TES array. It is a 4-pixels detector made of wide area Silicon absorbers sensed by Ir TESes, and put at a distance < 1 mm below the TES-array. On October 2015 the X-IFU Phase A program has been kicked-off, and about the CryoAC is at present foreseen on early 2017 the delivery of the DM1 (Demonstration Model 1) to the FPA development team for integration, which is made of 1 pixel "bridgessuspended" that will address the final design of the CryoAC. Both the background studies and the detector development work is on-going to provide confident results about the expected residual background at the TES-array level, and the single pixel design to produce a detector for testing activity on 2016/2017. Here we will provide an overview of the CryoAC program, discussing some details about the background assessment having impact on the CryoAC design, the last single pixel characterization

  7. Effect of focus position of ns pulse laser on damage characteristics of K9 glass

    Science.gov (United States)

    Pan, Yunxiang; Zhang, Hongchao; Li, Mengmeng; Shen, Zhonghua; Lu, Jian; Ni, Xiaowu

    2015-05-01

    Laser-induced damage of optical glasses has been investigated for more than fifty years. Due to the residual scratches, inclusions and other forms of defects at surfaces of optical glasses after the processes of grinding and polishing, it is well known that the sample surface can be damaged more easily than bulk. In order to get the relationship between the damage threshold and the location of the laser spot, we carried out damage experiments on K9 glasses with a 7ns pulse laser. Since ns pulse laser-induced damage of optical glasses always accompanies with the generation of the plasma, a optical microscope connected with a CCD camera was used to observe the plasma flash, which can provide a real time detection of damage sites. The laser pulse was first focused into the bulk, then the spot was moved toward the direction of incident laser beam step by step until the beam was completely focused in ambient air. Damage threshold curves were measured for each focus position, and low thresholds and high thresholds were extracted from those curves. Finally, the relationship between damage thresholds and focus position was analyzed.

  8. Effect of amorphous C films deposited by RF magnetron sputtering on smoothing K9 glass substrate

    Science.gov (United States)

    Deng, Songwen; Qi, Hongji; Wei, Chaoyang; Yi, Kui; Fan, Zhengxiu; Shao, Jianda

    2009-12-01

    Soft X-ray multilayer reflectors must be deposited on super-smooth surface such as super-polished silicon wafers or glasses, which are complicate, time-consuming and expensive to produce. To overcome this shortage, C films deposited by RF magnetron sputtering were considered to smooth the K9 glass substrates' surface in the present paper. The structure of C films was systematically studied by XRD and Raman spectrum. The surface morphology and rms-roughness were obtained by AFM. Then, we calculated the impact of the C layers on the reflectivity curve of Mo/Si soft X-ray multilayer reflector around 13.5 nm. The C films exhibit typical amorphous state. With the increasing of power and thickness, the content of sp3 hybrid bonding decreases while the amount or size of well-organized graphite clusters increases. The surface rms-roughness decreases from 2.4 nm to 0.62 nm after smoothed by an 80 nm thick C layer deposited in 500 W, which is the smoothest C layer surface we have obtained. The calculation results show that the theoretical normal incidence reflectivity of Mo/Si multilayer at 13.5 nm increases from 7% to 63%.

  9. Mutations in keratin K9 in kindreds with epidermolytic palmoplantar keratoderma and epidemiology in Northern Ireland.

    Science.gov (United States)

    Covello, S P; Irvine, A D; McKenna, K E; Munro, C S; Nevin, N C; Smith, F J; Uitto, J; McLean, W H

    1998-12-01

    Epidermolytic palmoplantar keratoderma (EPPK, MIM #144200) is an autosomal dominant disorder in which hyperkeratosis confined to the palms and soles is characterized histologically by cytolysis of suprabasal keratinocytes. Mutations in the keratin 9 gene (KRT9), a type 1 keratin expressed exclusively in the suprabasal keratinocytes of palmoplantar epidermis, have previously been demonstrated in this disorder. Here, we have studied four Northern Irish kindreds presenting with EPPK. By direct sequencing of polymerase chain reaction products, heterozygous missense mutations in exon 1 of KRT9 were detected in all the families. These included a novel mutation M156T; as well as M156V in two kindreds; and R162Q in the remaining family. All mutations were confirmed by reverse strand sequencing and restriction enzyme analysis. The point prevalence of EPPK in Northern Ireland was found to be 4.4 per 100,000. To date, all reported EPPK mutations occur in the helix initiation motif at the start of the central coiled-coil rod domain of K9.

  10. Purification and partial characterization of a tripeptidase from Pediococcus pentosaceus K9.2.

    Science.gov (United States)

    Simitsopoulou, M; Vafopoulou, A; Choli-Papadopoulou, T; Alichanidis, E

    1997-12-01

    A tripeptidase was purified from the cytoplasm of Pediococcus pentosaceus K9.2 by anion-exchange chromatography, gel filtration chromatography, and high-performance liquid chromatography. The molecular mass of the enzyme was estimated by gel filtration at 100,000 Da. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified peptidase showed one protein band of 45,000 Da. Optimal enzyme activity was obtained at pH 7.0 and at 50 degrees C. The peptidase hydrolyzed all tripeptides tested. Cleavage was not observed with dipeptides, oligopeptides, or amino acid-p-nitroanilide derivatives. Strong inhibition of activity was caused by EDTA, 1,10-phenanthroline, dithiothreitol, and beta-mercaptoethanol, whereas phenylmethylsulfonyl fluoride and sulfur-reactive reagents had no effect on peptidase activity. Mg2+, Mn2+, and Ca2+ stimulated the hydrolyzing activity of the enzyme. The 20 N-terminal amino acids of the tripeptidase from P. pentosaceus had 84% identity with those from the corresponding N-terminal region of the tripeptidase from Lactococcus lactis subsp. cremoris Wg2.

  11. 俄罗斯进口 K9焦煤在本钢的应用研究%Application research of Russian imported K9 coking coal in Bensteel

    Institute of Scientific and Technical Information of China (English)

    邢毅; 王文光; 翟向军; 韩颖; 李利凯

    2015-01-01

    通过质量检测、煤的岩相分析、40 kg试验焦炉炼焦试验,对俄罗斯进口K9焦煤的煤质特性和结焦特性进行了研究。结果表明K9煤低灰、低硫,为单一煤层煤,煤质稳定,配煤炼焦时有利于焦炭质量稳定,提高焦炭平均粒度和抗碎强度。在使用K9焦煤时,还可以配入高硫肥煤。%Russian imported K9 coking coal was investigated on coal quality and coking property by means of quality detection, petrographic analysis of coal and 40kg testing coke oven test.The result in-dicated that K9 coal was featured with low ash, low sulfur and stable quality, belonging to single coal seam.So it is beneficial to stabilize coke quality and improve coke average particle size and crushing strength in coal blending and coking.Meanwhile, fat coal with high sulfur content can be used in co-king.

  12. Molecular Targets of Chromatin Repressive Mark H3K9me3 in Primate Progenitor Cells within Adult Neurogenic Niches

    Directory of Open Access Journals (Sweden)

    Michael R Foret

    2014-07-01

    Full Text Available Histone 3 Lysine 9 (H3K9 methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3 is enriched in an adult neural stem cell niche- the subventricular zone (SVZ on the walls of the lateral ventricle in both rodent and non-human primate baboon brain. Previous studies have shown that there is significant correlation between baboon and human regarding genomic similarity and brain structure, suggesting that findings in baboon are relevant to human. To understand the function of H3K9me3 in this adult neurogenic niche, we performed genome-wide analyses using ChIP-Seq (chromatin immunoprecipitation and deep-sequencing and RNA-Seq for in vivo SVZ cells purified from baboon brain. Through integrated analyses of ChIP-Seq and RNA-Seq, we found that H3K9me3-enriched genes associated with cellular maintenance, post-transcriptional and translational modifications, signaling pathways, and DNA replication are expressed, while genes involved in axon/neuron, hepatic stellate cell, or immune-response activation are not expressed. As neurogenesis progresses in the adult SVZ, cell fate restriction is essential to direct proper lineage commitment. Our findings highlight that H3K9me3 repression in undifferentiated SVZ cells is engaged in the maintenance of cell type integrity, implicating a role for H3K9me3 as an epigenetic mechanism to control cell fate transition within this adult germinal niche.

  13. Research on Coal Quality and Coking Property of Russian Imported K9 Coking Coal%俄罗斯进口K9焦煤煤质特性与结焦特性研究

    Institute of Scientific and Technical Information of China (English)

    王文光; 李立凯; 李春那; 王军; 丁娜; 顾雪霞; 隋月诗

    2012-01-01

    通过质量检测、煤的岩相分析、40kg试验焦炉炼焦试验,对俄罗斯进口K9焦煤的煤质特性和结焦特性进行了研究,K9煤低灰、低硫,为单一煤层煤,煤质稳定,配煤炼焦有利于焦炭质量稳定.K9焦煤的结焦性能略好于我厂使用的国内中钢2号焦煤的结焦性能.

  14. 固结磨料研磨K9玻璃表面粗糙度模型%Model of Surface Roughness in Fixed Abrasive Lapping of K9 Glass

    Institute of Scientific and Technical Information of China (English)

    李军; 王慧敏; 王文泽; 黄建东; 朱永伟; 左敦稳

    2015-01-01

    Surface roughness model is an important basis for lapping process design and process parameter selection. K9 glass is one of the most widely applied optical materials. The model of surface roughness in lapping of K9 glass is established to improve processing efficiency and save production cost. Based on surface microstructure of the lapping pad, fixed abrasive lapping process is simplified, and the number of effective abrasives and the single abrasive depth of cutting into the workpiece are calculated. Combing the force equilibrium in lapping process, surface roughness model of fixed abrasive lapping of K9 glass is established. The model is verified by lapping of K9 glass with different abrasive particle sizes and concentrations, as well as different pressures. The results show that surface roughness of K9 glass is proportional to particle size and one-third power of lapping pressure, and inversely proportional to two-ninth power of the pad concentration. The changing trend of theoretical surface roughness values over abrasive particle sizes and pad concentrations as well as lapping pressures matches experimental trend. Surface roughness of K9 glass can be successfully predicted by the model in fixed abrasive lapping process, which can be used to guide the lapping process design and process parameters selection with high reliability.%表面粗糙度模型是研磨过程设计和工艺参数选择的重要依据,K9 玻璃是应用最广泛的光学材料之一.建立研磨 K9玻璃表面粗糙度模型有利于提高加工效率、节约生产成本.简化固结磨料研磨过程,基于研磨垫表面微结构,计算研磨过程中参与研磨的有效磨粒数和单颗磨粒切入工件深度,利用研磨过程中受力平衡,建立固结磨料研磨K9玻璃表面粗糙度模型.采用不同磨粒粒径和不同磨料浓度的固结磨料研磨垫以及不同压力研磨K9玻璃验证表面粗糙度模型.结果表明:固结磨料研磨K9玻璃

  15. Measurement for bulk and surface absorptances of K9 substrates with laser calorimeter%激光量热法测量K9基片的表面吸收和体吸收

    Institute of Scientific and Technical Information of China (English)

    刘浩; 潘峰; 陈松林; 王震; 马平; 欧阳升; 卫耀伟

    2014-01-01

    表面抛光可能给K9基片带来额外的杂质和吸收,分离K9基片的表面吸收率与体吸收率有助于改进基片的加工质量和抛光工艺,对抗损伤能力研究具有重要意义.分析了激光量热法测量弱吸收的原理,采用符合ISO 11551要求的激光量热计测量K9基片的弱吸收.对相同工艺抛光的不同厚度K9基片进行了弱吸收表征,实验发现K9基片的弱吸收随着厚度增加近似线性增大.推导了表面吸收率和体吸收率的计算式,实验得出本样品的表面吸收率为1.21×10-5,体吸收率远大于表面吸收率,体吸收系数为1.72×10-3/cm.实验结果显示所用K9样品的吸收主要来自于材料本身,改善抛光工艺对降低其吸收率作用不大.

  16. 脉冲CO2激光损伤K9玻璃的实验与仿真%Simulation and Experimental Research on Damage in K9 Glass due to Pulsed CO2 Laser Radiation

    Institute of Scientific and Technical Information of China (English)

    王玺; 李化; 聂劲松

    2008-01-01

    对脉冲CO2激光损伤K9玻璃进行了实验与仿真研究.采用输出脉宽为10μs的脉冲CO2激光器对K9玻璃样品进行激光损伤实验,并且建立了脉冲CO2激光损伤K9玻璃的理论模型,利用有限元法对K9玻璃样品中的温度和应力分布进行数值分析.研究表明,K9玻璃的损伤阈值为6.533 J/cm2;入射激光能量密度越高,样品的损伤程度就越大,并且多脉冲对样品的损伤程度明显大于单脉冲;在激光能量较强的情况下,K9玻璃表面在光斑区域内形成熔融损伤和由压缩应力造成的应力损伤,在光斑区域外围则形成由环向拉伸应力造成的应力损伤,仿真分析结果与实验结果吻合良好.

  17. Analysis of damage threshold of K9 glass irradiated by 248-nm KrF excimer laser

    Science.gov (United States)

    Wang, Xi; Shao, Jingzhen; Li, Hua; Nie, Jinsong; Fang, Xiaodong

    2016-02-01

    The theoretical model of K9 glass irradiated by a 248-nm KrF excimer laser was established, and a numerical simulation was performed to calculate temperature and thermal stress fields in the K9 glass sample using the finite element method. The laser-induced damage thresholds were defined and calculated, and the effect of repetition frequency and the number of pulses on the damage threshold were also studied. Furthermore, the experiment research was carried out to confirm the numerical simulation. The damage threshold and damage morphology were analyzed by means of a metallurgical microscope and scanning electron microscopy. The simulation and experimental results indicated that the damage mechanism of K9 glass irradiated by a KrF excimer laser was melting damage and stress damage, and the stress damage first appeared inside the K9 glass sample. The tensile stress damage threshold, the compressive stress damage threshold, and the melting damage threshold were 0.64, 0.76, and 1.05 J/cm2, respectively. The damage threshold decreased with increasing repetition frequency and number of laser pulses. The experimental results indicated that the damage threshold of K9 glass was 2.8 J/cm2.

  18. A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.

    Science.gov (United States)

    Shirato, Haruki; Ogawa, Satoko; Nakajima, Kuniko; Inagawa, Masayo; Kojima, Mizuyo; Tachibana, Makoto; Shinkai, Yoichi; Takeuchi, Takashi

    2009-01-09

    Covalent modifications of histone tails have critical roles in regulating gene expression. Previously, we identified the jumonji (jmj, Jarid2) gene, the jmjC domain, and a Jmj family. Recently, many Jmj family proteins have been shown to be histone demethylases, and jmjC is the catalytic domain. However, Jmj does not have histone demethylase activity because the jmjC domain lacks conserved residues for binding to cofactors. Independently of these studies, we previously showed that Jmj binds to the cyclin D1 promoter and represses the transcription of cyclin D1. Here, we show the mechanisms by which Jmj represses the transcription of cyclin D1. We found that a protein complex of Jmj had histone methyltransferase activity toward histone H3 lysine 9 (H3-K9). We also found that Jmj bound to the H3-K9 methyltransferases G9a and GLP. Expression of Jmj recruited G9a and GLP to the cyclin D1 promoter and increased H3-K9 methylation. Inactivation of both G9a and GLP, but not of only G9a, inhibited the methylation of H3-K9 in the cyclin D1 promoter and repression of cyclin D1 expression by Jmj. These results suggest that Jmj methylates H3-K9 and represses cyclin D1 expression through G9a and GLP, and that Jmj family proteins can regulate gene expression by not only histone demethylation but also other histone modification.

  19. Analysis of temperature and thermal stress fields of K9 glass damaged by 1064nm nanosecond pulse laser

    Science.gov (United States)

    Pan, Yunxiang; Shen, Zhonghua; Lu, Jian; Ni, Xiaowu

    2013-02-01

    There are residual scratches, inclusions and other forms of defects at surfaces of optical materials after the processes of grinding and polishing, which could either enhance the local electric field or increase the absorption rate of the material. As a result, the laser-induced damage threshold at the surface of the material is reduced greatly. In order to study underlying mechanisms and process of short pulsed laser-induced damage to K9 glass, a spatial axisymmetric model where the K9 glass was irradiated by a laser whose wavelength and pulse width are respectively 1064nm and 10ns was established. Taking into account the fact that the surface of the K9 glass is more likely to be damaged, 2μm-thick layers whose absorption coefficients are larger than bulk were set at both the input and output surfaces in the model. In addition, the model assumed that once the calculated tensile/compressive stress was greater than the tensile/compressive strength of K9 glass, the local absorption coefficient increased. The finite element method(FEM) was applied to calculate the temperature and thermal stress fields in the K9 glass. Results show that only the temperature of a small part of interacted region exceeds the melting point, while most of the damage pit is generated by thermal stress. The simulated damage morphology and the size of the damage region are consistent with those reported in literatures, which indicates that the model built in our work is reasonable.

  20. Study on Traffic Thematic Maps Based on MapGIS K9 and Image Fusion%基于影像融合的MapGIS K9交通专题图制作研究

    Institute of Scientific and Technical Information of China (English)

    袁媛; 向怀坤; 张文绩

    2014-01-01

    研究将全色影像和多光谱影像在MapGIS K9遥感影像处理平台进行融合的方法,使融合后的影像既有正确的投影信息又有丰富的色彩和较高的空间分辨率.以融合后的影像为底图,研究利用MapGIS K9制作交通专题图的方法.

  1. Experiment on damage in K9 glass due to repetition rate pulsed CO2 laser radiation%重频脉冲CO2激光损伤K9玻璃的实验

    Institute of Scientific and Technical Information of China (English)

    王玺; 卞进田; 李华; 聂劲松; 孙晓泉; 尹学忠; 雷鹏

    2013-01-01

      对脉冲CO2激光在不同重频模式下损伤K9玻璃进行了实验研究。采用输出能量为10 J,脉宽为90 ns,重复频率在100 Hz至300 Hz之间连续可调的脉冲CO2激光器,对K9玻璃样品进行了激光损伤实验,观察到两次不同重频条件下样品的损伤形貌。实验结果表明,重频越高,对样品的损伤程度就越严重;应力损伤成为K9玻璃激光损伤的最主要的原因,在重频强激光的辐照下,K9玻璃表面出现强烈的等离子体闪光,伴随明显的熔融气化破坏,并形成等离子体爆轰波。爆轰波对玻璃材料产生了严重的力学冲击作用,这种应力作用足以对K9玻璃造成毁灭性破坏。运用有限元分析对激光辐照K9玻璃的温度与应力分布进行仿真,其计算结果与实验基本吻合。%  In this paper, the experiment on damage in K9 glass induced by pulsed CO2 laser under different repetition rates was carried out, which had a pulse width of 90 ns. The laser pulse energy was 10 J and the repetition rate was kept within the range of 100 Hz to 300 Hz. The damage morphologies of two kind repetition rates after laser irradiation were characterized. The experimental results indicate that the effect of laser irradiation on samples can be affected considerably by the change of laser repetition rate, and the intensity of damage morphology on the sample increases with the laser repetition rate, and the damage in K9 glass induced by pulsed CO2 laser is dominated by stress. As a result, the plasma detonation wave induced by laser occured, the material was broken result from the melting and evaporation of K9 glass. It is shown that the plasma detonation wave affected stress damage considerably, and this mechanical effect almost destroyed K9 glass sample. A numerical simulation was performed to calculate temperature and stress distributions in K9 glass sample irradiated by pulsed CO2 laser using finite element method. The model

  2. 优良K9苹果优质丰产配套栽培技术

    Institute of Scientific and Technical Information of China (English)

    李占印; 任宝君

    2014-01-01

    K9苹果,又名七月鲜,是辽宁省果树科学研究所以佚名大苹果为母本、铃铛果为父本杂交选育而成的.近年来在朝阳市的建平县、凌源市栽培表现果色艳丽、酸甜适口、果型圆正等诸多优良特性,根据K9在辽西北地区的生长特性,总结了苹果K9的园地选择、栽植、整形修剪、肥水管理、病虫害防治等系列关键技术.

  3. ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation.

    Science.gov (United States)

    Karagianni, Panagiota; Amazit, Larbi; Qin, Jun; Wong, Jiemin

    2008-01-01

    Methylation of histone H3 on lysine 9 is critical for diverse biological processes including transcriptional repression, heterochromatin formation, and X inactivation. The biological effects of histone methylation are thought to be mediated by effector proteins that recognize and bind to specific patterns of methylation. Using an unbiased in vitro biochemical approach, we have identified ICBP90, a transcription and cell cycle regulator, as a novel methyl K9 H3-specific binding protein. ICBP90 and its murine homologue Np95 are enriched in pericentric heterochromatin of interphase nuclei, and this localization is dependent on H3K9 methylation. Specific binding of ICBP90 to methyl K9 H3 depends on two functional domains, a PHD (plant homeodomain) finger that defines the binding specificity and an SRA (SET- and RING-associated) domain that promotes binding activity. Furthermore, we present evidence that ICBP90 is required for proper heterochromatin formation in mammalian cells.

  4. OVERVIEW OF RECENT EXPERIMENTAL RESULTS FROM THE DIII-D ADVANCED TOKAMAK PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    BURRELL,HK

    2002-11-01

    OAK A271 OVERVIEW OF RECENT EXPERIMENTAL RESULTS FROM THE DIII-D ADVANCED TOKAMAK PROGRAM. The DIII-D research program is developing the scientific basis for advanced tokamak (AT) modes of operation in order to enhance the attractiveness of the tokamak as an energy producing system. Since the last International Atomic Energy Agency (IAEA) meeting, they have made significant progress in developing the building blocks needed for AT operation: (1) they have doubled the magnetohydrodynamic (MHD) stable tokamak operating space through rotational stabilization of the resistive wall mode; (2) using this rotational stabilization, they have achieved {beta}{sub N}H{sub 89} {ge} 10 for 4 {tau}{sub E} limited by the neoclassical tearing mode; (3) using real-time feedback of the electron cyclotron current drive (ECCD) location, they have stabilized the (m,n) = (3,2) neoclassical tearing mode and then increased {beta}{sub T} by 60%; (4) they have produced ECCD stabilization of the (2,1) neoclassical tearing mode in initial experiments; (5) they have made the first integrated AT demonstration discharges with current profile control using ECCD; (6) ECCD and electron cyclotron heating (ECH) have been used to control the pressure profile in high performance plasmas; and (7) they have demonstrated stationary tokamak operation for 6.5 s (36 {tau}{sub E}) at the same fusion gain parameter of {beta}{sub N}H{sub 89}/q{sub 95}{sup 2} {approx} 0.4 as ITER but at much higher q{sub 95} = 4.2. The authors have developed general improvements applicable to conventional and advanced tokamak operating modes: (1) they have an existence proof of a mode of tokamak operation, quiescent H-mode, which has no pulsed, ELM heat load to the divertor and which can run for long periods of time (3.8 s or 25 {tau}{sub E}) with constant density and constant radiated power; (2) they have demonstrated real-time disruption detection and mitigation for vertical disruption events using high pressure gas jet

  5. Trends in Canadian faculties of education: An overview of graduate programs, curricular offerings, exit requirements, and modes of delivery.

    Directory of Open Access Journals (Sweden)

    Carla Abreu Ellis

    2008-07-01

    Full Text Available Introduction This research investigated universities registered with the Association of Universities and Colleges of Canada (AUCC whose primary instructional language was English. A content analysis was performed on university web pages related to the following content: (a frequency of graduate programs being offered, (b types of degrees being offered, (c frequency and variation of program of study offerings, (d variation of exit requirements, and (e modalities of course delivery. This research provides an overview and analysis of graduate level programs, more precisely Masters and Doctorate degrees, offered through faculties of education in Canada. An understanding of the findings of this research may benefit Canadian university administrative bodies in providing a source in which they may compare findings with their current offerings and programming. Prospective students of graduate programs in education may also benefit from the information provided in this study when choosing a program of study by ameliorating their knowledge of current programs, curriculum offerings, and modes of course delivery being offered by faculties of education in Canada.

  6. 准分子激光辐照K9玻璃的热力效应分析%Thermal and mechanical damage in K9 glass irradiated by KrF excimer laser

    Institute of Scientific and Technical Information of China (English)

    王玺; 方晓东

    2016-01-01

    A numerical simulation is performed to calculate temperature and stress distributions in K9 glass sample irradia-ted by KrF excimer laser using finite element method,and the relationship between laser parameters and damage effect is also studied.The simulation results indicate that the damage of K9 glass irradiated by KrF excimer laser is thermal stress damage when the incident laser energy is low.The stress damage in laser spot area is dominated by compressive stress,and the damage near the edge of the spot or inside the K9 glass is dominated by tensile stress.The thermal stress as shock wave oscillates obvi-ously inside the K9 glass sample.It is shown that repetition frequency and the number of pulses affect damage considerably,and the accumulation of multi-shot laser induced damage in K9 glass is obvious.%基于传热学理论,利用有限元法对KrF准分子激光辐照K9 玻璃样品中的热力效应进行了数值分析,并比较了脉冲数目和重频对损伤效果的影响.研究表明,较低的准分子激光能量就能够使 K9 玻璃在表面和体内产生热应力损伤,热应力损伤在光斑区域内主要由压缩热应力控制,在光斑边缘和材料内部则主要由拉伸热应力控制.在激光脉冲结束时刻,产生的温度和热应力最大,且热应力以热冲击波的形式在材料内传播,随时间变化而来回振荡,逐渐减弱.这种热应力的反复冲击会对材料产生持续的损伤增长效应,增加了材料的损伤时间,并使材料更容易断裂.脉冲数目和重复频率对损伤效果有着较大影响,在高重复频率下,损伤累积效应明显.

  7. Overview Presentation

    Science.gov (United States)

    Lytle, John

    2001-01-01

    This report provides an overview presentation of the 2000 NPSS (Numerical Propulsion System Simulation) Review and Planning Meeting. Topics include: 1) a background of the program; 2) 1999 Industry Feedback; 3) FY00 Status, including resource distribution and major accomplishments; 4) FY01 Major Milestones; and 5) Future direction for the program. Specifically, simulation environment/production software and NPSS CORBA Security Development are discussed.

  8. 固结磨料研磨掺铈玻璃与K9玻璃的对比研究%Research on fixed abrasive lapping of cerium doped glass and K9 glass

    Institute of Scientific and Technical Information of China (English)

    夏磊; 李军; 李鹏鹏; 朱永伟; 王文泽; 左敦稳

    2013-01-01

    在相同研磨条件下,采用固结磨料研磨垫研磨掺铈玻璃和K9玻璃,比较掺铈玻璃和K9玻璃的研磨材料去除率,研磨摩擦系数值和加工后表面质量.研究结果表明:金刚石固结磨料研磨垫对掺铈玻璃的材料去除率和研磨摩擦系数小于K9玻璃,表面质量相对较优.掺铈玻璃残屑中的Ce与Si在金刚石颗粒表面及磨粒之间形成包裹层和填覆层,改变材料去除机理,导致材料去除率和摩擦系数下降,获得更优的表面质量.%Fixed abrasive pad was employed to lap cerium doped glass and K9 glass in the same condition. Material removal rate(MRR) , lapping friction coefficient and surface quality were investigated. Results showed that MRR and lapping friction coefficient of cerium doped glass were less than those of K9 glass, but surface quality was better. The Ce and Si from the chips of cerium doped glass formed a covering layer on diamond particle surface and a filling layer in the gap between abrasives, thus changing the material removal mechanism. MRR and friction coefficient declined, and surface quality got better.

  9. Cloning, characterization and serological evaluation of K9 and K26: two related hydrophilic antigens of Leishmania chagasi.

    Science.gov (United States)

    Bhatia, A; Daifalla, N S; Jen, S; Badaro, R; Reed, S G; Skeiky, Y A

    1999-08-20

    We report here the molecular cloning and characterization of two related hydrophilic antigens of Leishmania chagasi. These two antigens have predicted molecular weights of approximately 9 and 26 kDa and detect antibodies in sera of patients with kala-azar (k). Thus, to maintain consistency with nomenclature of the previously described 39 kDa diagnostic antigen of L. chagasi (k39 [1]), these antigens are being referred to as k9 and k26. A significant difference between k9 and k26 is the presence of 11 copies of a 14 amino acid repeat in the open reading frame of k26. The region flanking the repeats of k26 shares a 69% identity with the open reading frame of k9. The recombinant proteins encoded by both antigens are very hydrophilic and show aberrant migration on SDS PAGE. Results of Southern blot analysis reveal that k9 and k26 are conserved to varying degrees among various Leishmania species. Interestingly, the repeat region of k26 is specific to L. chagasi and L. donovani while the flanking region is conserved among several other species. Transcript levels of k26 are significantly upregulated in the amastigote stage of the parasite. Our results show that recombinant K26 is specific in detecting antibodies in infection sera from visceral leishmaniasis (VL) patients. Thus rK26 may complement rK39 in a more accurate diagnosis of VL in the old and the new world.

  10. Transient absorption and luminescence spectra of K9 glass at sub-damage site by ultraviolet laser irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Z., E-mail: namezhangzhen@126.com [Science and Technology on Plasma Physics Laboratory, Research Center of Laser Fusion (China); Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610000 (China); Huang, J.; Geng, F.; Zhou, X.Y. [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Feng, S.Q. [Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610000 (China); Cheng, X.L., E-mail: chengxl@scu.edu.cn [Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610000 (China); Jiang, X.D. [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Wu, W.D. [Science and Technology on Plasma Physics Laboratory, Research Center of Laser Fusion (China); Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610000 (China); Zheng, W.G.; Tang, Y.J. [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China)

    2014-01-01

    Highlights: • Transient absorption and luminescence spectra at sub-damage site of K9 glass by laser irradiation at 355 nm are presented. • As the energy density increases to 2.54 J/cm{sup 2}, the absorption intensity reaches to about 0.2. • The mechanism of two-photon ionization mainly plays a critical role at sub-damage site. • Intensity of Raman spectra is very high at low energy density and decreased with respect to high energy density. -- Abstract: Transient absorption and luminescence spectra at sub-damage site of K9 glass by laser irradiation at 355 nm are presented. The dependence of transient absorption on laser energy and number of pulses was investigated. As the energy density increases to 2.54 and 3.18 J/cm{sup 2}, the transient absorption intensity reaches to about 0.20 range from 400 to 480 nm. With the increase of number of pulses the process of residual absorption appears, which can be used to explain the fatigue effect of K9 glass. The defects in K9 glass were investigated by fluorescence and Raman spectra. The fluorescence band centered at about 410 nm is attributed to oxygen deficiency centers. The mechanism of two-photon ionization plays a critical role at sub-damage site. Compared to the Raman spectra of pristine site, intensity of Raman spectra is very high at a lower energy density, while it decreased at a higher energy density.

  11. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.

    Science.gov (United States)

    Schotta, Gunnar; Lachner, Monika; Sarma, Kavitha; Ebert, Anja; Sengupta, Roopsha; Reuter, Gunter; Reinberg, Danny; Jenuwein, Thomas

    2004-06-01

    Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in mammals. Here we show that H4-K20 trimethylation is also focally enriched at pericentric heterochromatin. Intriguingly, H3-K9 trimethylation by the Suv39h HMTases is required for the induction of H4-K20 trimethylation, although the H4 Lys 20 position is not an intrinsic substrate for these enzymes. By using a candidate approach, we identified Suv4-20h1 and Suv4-20h2 as two novel SET domain HMTases that localize to pericentric heterochromatin and specifically act as nucleosomal H4-K20 trimethylating enzymes. Interaction of the Suv4-20h enzymes with HP1 isoforms suggests a sequential mechanism to establish H3-K9 and H4-K20 trimethylation at pericentric heterochromatin. Heterochromatic H4-K20 trimethylation is evolutionarily conserved, and in Drosophila, the Suv4-20 homolog is a novel PEV modifier to regulate position-effect variegation. Together, our data indicate a function for H4-K20 trimethylation in gene silencing and further suggest H3-K9 and H4-K20 trimethylation as important components of a repressive pathway that can index pericentric heterochromatin.

  12. K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase.

    Science.gov (United States)

    Kobza, Keyna; Camporeale, Gabriela; Rueckert, Brian; Kueh, Alice; Griffin, Jacob B; Sarath, Gautam; Zempleni, Janos

    2005-08-01

    Histones are modified post-translationally, e.g. by methylation of lysine and arginine residues, and by phosphorylation of serine residues. These modifications regulate processes such as gene expression, DNA repair, and mitosis and meiosis. Recently, evidence has been provided that histones are also modified by covalent binding of the vitamin biotin. The aims of this study were to identify biotinylation sites in histone H3, and to investigate the crosstalk among histone biotinylation, methylation and phosphorylation. Synthetic peptides based on the sequence of human histone H3 were used as substrates for enzymatic biotinylation by biotinidase; biotin in peptides was probed using streptavidin peroxidase. These studies provided evidence that K4, K9 and K18 in histone H3 are good targets for biotinylation; K14 and K23 are relatively poor targets. Antibodies were generated to histone H3, biotinylated either at K4, K9 or K18. These antibodies localized to nuclei in human placental cells in immunocytochemistry and immunoblotting experiments, suggesting that lysines in histone H3 are biotinylated in vivo. Dimethylation of R2, R8 and R17 increased biotinylation of K4, K9 and K18, respectively, by biotinidase; phosphorylation of S10 abolished biotinylation of K9. These observations are consistent with crosstalk between biotinylation of histones and other known modifications of histones. We speculate that this crosstalk provides a link to known roles for biotin in gene expression and cell proliferation.

  13. H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases

    DEFF Research Database (Denmark)

    Hansen, Klavs R; Hazan, Idit; Shanker, Sreenath;

    2011-01-01

    Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both multicellular eukaryotes and single-cell model...

  14. H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.

    Science.gov (United States)

    Paschall, Amy V; Yang, Dafeng; Lu, Chunwan; Choi, Jeong-Hyeon; Li, Xia; Liu, Feiyan; Figueroa, Mario; Oberlies, Nicholas H; Pearce, Cedric; Bollag, Wendy B; Nayak-Kapoor, Asha; Liu, Kebin

    2015-08-15

    The Fas-FasL effector mechanism plays a key role in cancer immune surveillance by host T cells, but metastatic human colon carcinoma often uses silencing Fas expression as a mechanism of immune evasion. The molecular mechanism under FAS transcriptional silencing in human colon carcinoma is unknown. We performed genome-wide chromatin immunoprecipitation sequencing analysis and identified that the FAS promoter is enriched with H3K9me3 in metastatic human colon carcinoma cells. The H3K9me3 level in the FAS promoter region is significantly higher in metastatic than in primary cancer cells, and it is inversely correlated with Fas expression level. We discovered that verticillin A is a selective inhibitor of histone methyltransferases SUV39H1, SUV39H2, and G9a/GLP that exhibit redundant functions in H3K9 trimethylation and FAS transcriptional silencing. Genome-wide gene expression analysis identified FAS as one of the verticillin A target genes. Verticillin A treatment decreased H3K9me3 levels in the FAS promoter and restored Fas expression. Furthermore, verticillin A exhibited greater efficacy than decitabine and vorinostat in overcoming colon carcinoma resistance to FasL-induced apoptosis. Verticillin A also increased DR5 expression and overcame colon carcinoma resistance to DR5 agonist drozitumab-induced apoptosis. Interestingly, verticillin A overcame metastatic colon carcinoma resistance to 5-fluorouracil in vitro and in vivo. Using an orthotopic colon cancer mouse model, we demonstrated that tumor-infiltrating cytotoxic T lymphocytes are FasL(+) and that FasL-mediated cancer immune surveillance is essential for colon carcinoma growth control in vivo. Our findings determine that H3K9me3 of the FAS promoter is a dominant mechanism underlying FAS silencing and resultant colon carcinoma immune evasion and progression.

  15. A National Overview of Staff and Program Characteristics 1984-1985. HEP/CAMP National Evaluation Project. Research Report No. 1.

    Science.gov (United States)

    Riley, Gary L.

    One of four products of the 1984-85 National Evaluation Project to compile baseline data on characteristics and impacts of High School Equivalency Programs (HEP) and College Assistance for Migrants Programs (CAMP), this report presents a brief overview of the goals, basic research design, and summary of the evaluation project products and a…

  16. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  17. 75 FR 43510 - Office of Innovation and Improvement; Overview Information; Charter Schools Program (CSP) Grants...

    Science.gov (United States)

    2010-07-26

    ...-State Educational Agencies for Planning, Program Design, and Implementation and for Dissemination.... The non-State educational agency (non-SEA) grants for planning, program design, and implementation... program. 5. Funding Restrictions: Use of Funds for Post-Award Planning and Design of the...

  18. The Math and Science Partnership Program Evaluation: Overview of the First Two Years

    Science.gov (United States)

    Yin, Robert K.

    2008-01-01

    This study describes the Math and Science Partnership Program Evaluation (MSP-PE) during the project's first two years and provides the evaluation framework being used to assess the National Science Foundation's MSP Program. The study conveys the MSP-PE's ongoing design and implementation. To show how they reflect the nature of the MSP Program,…

  19. 青兰高速二灰土(水泥/石灰/土)试验段(k9+412-k9+740)施工方法

    Institute of Scientific and Technical Information of China (English)

    刘庆滨

    2008-01-01

    路基综合稳定土简称二灰土,它是水泥、石灰、土的混合料。现广泛应用在高速、一级路的路基底基层的施工上,因他的施工工艺技术含量要求较高,所以在正式大面积施工前,一定要做好施工试验段的全部技术指标的确定工作。以下就是青兰高速的试验段(K9+412-k9+740)的施工过程。

  20. K9玻璃磁性研磨抛光表面粗糙度试验研究%Research on surface roughness of K9 glass by magnetic abrasive finishing

    Institute of Scientific and Technical Information of China (English)

    丘永亮; 邱腾雄; 阎秋生

    2015-01-01

    针对 K9光学玻璃研磨抛光过程中存在的问题,将磁性研磨加工方法应用在光学玻璃的研磨抛光上。试验表明,K9玻璃的表面粗糙度值Ra由原来的90 nm 左右下降到40 nm 左右。为进一步研究磁性研磨试验的4个因素,设计了正交试验,最终得出各个因素对于工件表面粗糙度影响的主次顺序,并确定其最优组合为:磁极转速2300 r/min,加工间隙1.5 mm,磁感应强度0.4 T,进给速度200 mm/min。%To study the existing problems of polishing K9 optical glass,magnetic abrasive finishing was put forward in polishing optical glass•Results showed that surface roughness R a of K9 glass decreased from 90 nm to 40 nm•Based on the feasibility study,the magnetic abrasive finishing experiments were performed by orthogonal experiment with 4 parameters•Then various factors of magnetic abrasive finishing were listed in sequence•The optimum combination was that:pole speed of 2300 r∕min,working clearance of 1•5 mm,magnetic flux density of 0•4 T and feed rate of 200 mm∕min.

  1. H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus.

    Science.gov (United States)

    Snigdha, Shikha; Prieto, G Aleph; Petrosyan, Arpine; Loertscher, Brad M; Dieskau, André P; Overman, Larry E; Cotman, Carl W

    2016-03-23

    An increasing number of studies show that an altered epigenetic landscape may cause impairments in regulation of learning and memory-related genes within the aged hippocampus, eventually resulting in cognitive deficits in the aged brain. One such epigenetic repressive mark is trimethylation of H3K9 (H3K9me3), which is typically implicated in gene silencing. Here, we identify, for the first time, an essential role for H3K9me3 and its histone methyl transferase (SUV39H1) in mediating hippocampal memory functions. Pharmacological inhibition of SUV39H1 using a novel and selective inhibitor decreased levels of H3K9me3 in the hippocampus of aged mice, and improved performance in the objection location memory and fear conditioning tasks and in a complex spatial environment learning task. The inhibition of SUV39H1 induced an increase in spine density of thin and stubby but not mushroom spines in the hippocampus of aged animals and increased surface GluR1 levels in hippocampal synaptosomes, a key index of spine plasticity. Furthermore, there were changes at BDNF exon I gene promoter, in concert with overall BDNF levels in the hippocampus of drug-treated animals compared with control animals. Together, these data demonstrate that SUV39H1 inhibition and the concomitant H3K9me3 downregulation mediate gene transcription in the hippocampus and reverse age-dependent deficits in hippocampal memory. Cognitive decline is a debilitating condition associated with not only neurodegenerative diseases but also aging in general. However, effective treatments have been slow to emerge so far. In this study, we demonstrate that epigenetic regulation of key synaptic proteins may be an underlying, yet reversible, cause of this decline. Our findings suggest that histone 3 trimethylation is a probable target for pharmacological intervention that can counteract cognitive decline in the aging brain. Finally, we provide support to the hypothesis that, by manipulating the enzyme that regulates H3K9

  2. A critical overview of industrial energy decoupling programs in six developing countries in Asia

    Energy Technology Data Exchange (ETDEWEB)

    Luken, Ralph A., E-mail: SkipLuken@yahoo.com [UNIDO, PO Box 300 (Library), A-1400 Vienna (Austria); Piras, Stefano [UNIDO (Austria)

    2011-06-15

    In reviewing the journal literature on the decoupling of energy use and industrial output in the Asian region, particularly with respect to developing countries, we found little information about most country programs other than for China and India and only one article that compared the programs of these two countries. For this reason, we used diverse sources to identify the key programmatic features that have contributed, but clearly are not totally responsible for, decoupling achievements of two countries ( China and Thailand) and then, on the basis of these findings, reviewed emerging industrial energy decoupling programs in four other countries (India, Indonesia, Malaysia and Vietnam). We found that the design of the two successful on-going decoupling programs have common features, which are setting an explicit target for decoupling of energy use and industrial output, a government program that offers financial incentives and imposes specific auditing and reporting requirements and involvement of the manufacturing sector in designing and implementing targets as they apply to individual enterprises. We also found that the emerging programs in the other four countries lack some or all of these essential programmatic features. - Highlights: > We reviewed two on-going and four emerging industrial energy decoupling programs. > These six Asian developing countries have very different rates of decoupling. > The two successful on-going programs share three common features. > These are quantitative targets, supportive programs and industry involvement. > The four emerging programs lack some or all of these features.

  3. Aircraft structural health monitoring system development: overview of the Air Force/Navy smart metallic structures program

    Science.gov (United States)

    Van Way, Craig B.; Kudva, Jayanth N.; Schoess, Jeffrey N.; Zeigler, Michael L.; Alper, James M.

    1995-05-01

    Significant progress in fulfilling the current joint Air Force/Navy `Smart Metallic Structures (SMS)' program primary objective, to demonstrate a viable structural health monitoring system (SHMS) for a large structural aircraft component, is presented. Structural health monitoring and its relation to current Force Management (FM) and Aircraft Structural Integrity Program (ASIP) procedures are first reviewed together with a brief status overview of the relevant sensor technologies (e.g. AE, fiber-optic, corrosion, etc.). Key features of the SHMS architecture are described for the selected F/A-18 bulkhead and T-38 wing spar structural demonstration articles, highlighting sensors, processors, data busses, hardware, and software. Results from acoustic monitoring of the program sub-element structural tests are presented in some detail along with a status review of the SHMS multiplex bus component hardware and software. Finally, structural requirements for an SHMS meeting minimum ASIP guidelines for damage detection are discussed along with foals for future testing and development of the SHMS under the SMS program.

  4. Program definition and assessment overview. [for thermal energy storage project management

    Science.gov (United States)

    Gordon, L. H.

    1980-01-01

    The implementation of a program level assessment of thermal energy storage technology thrusts for the near and far term to assure overall coherent energy storage program is considered. The identification and definition of potential thermal energy storage applications, definition of technology requirements, and appropriate market sectors are discussed along with the necessary coordination, planning, and preparation associated with program reviews, workshops, multi-year plans and annual operating plans for the major laboratory tasks.

  5. Preventing cervical cancer : overviews of the National Breast and Cervical Cancer Early Detection Program and 2 US immunization programs.

    Science.gov (United States)

    Khan, Kris; Curtis, C Robinette; Ekwueme, Donatus U; Stokley, Shannon; Walker, Chastity; Roland, Katherine; Benard, Vicki; Saraiya, Mona

    2008-11-15

    Three federal programs with the potential to reduce cervical cancer incidence, morbidity, and mortality, especially among underserved populations, are administered by the Centers for Disease Control and Prevention (CDC): the National Breast and Cervical Cancer Early Detection Program (NBCCEDP), the Vaccines for Children (VFC) Program, and the Section 317 immunization grant program. The NBCCEDP provides breast and cervical cancer screening and diagnostic services to uninsured and underinsured women. The VFC program and the Section 317 immunization grant program provide vaccines, including human papillomavirus (HPV) vaccine, to targeted populations at no cost for these vaccines. This article describes the programs, their histories, populations served, services offered, and roles in preventing cervical cancer through HPV vaccination and cervical cancer screening. Potential long-term reduction in healthcare costs resulting from HPV vaccination is also discussed. As an example of an initiative to vaccinate uninsured women aged 19-26 years through a cancer services program, a state-based effort that was recently launched in New York, is highlighted.

  6. National waste terminal storage program: Office of Nuclear Waste Isolation Technical Program Plan. Volume 1, Technical Overview

    Energy Technology Data Exchange (ETDEWEB)

    1979-02-16

    A Technical Program Plan was developed detailing projected activities toward the development and operation of a geologic waste repository. This volume presents the overall program in summary fashion: objectives, technical scope, technical approach, schedule plan, FY 1979 budget and milestone plan, organization, management processes, and nuclear waste isolation issues. 8 figures, 8 tables. (DLC)

  7. Comparative investigation of damage performance on K9 and SiO2 under 1064-nm nanosecond laser irradiation

    Science.gov (United States)

    Liu, Hongjie; Wang, Fengrui; Zhang, Zhen; Huang, Jin; Zhou, Xinda; Jiang, Xiaodong; Wu, Weidong; Zheng, Wanguo

    2012-01-01

    Laser damage performance of K9 glass and fused silica glass were tested respectively at same experimental condition with 1064 nm nanosecond laser. The initial damage threshold (IDT), the damage growth threshold (DGT) and the damage growth laws of the two optics glass were investigated comparatively. The results show that the damage growth behavior of the two glasses are quite different, for example, the lower damage growth threshold and the higher damage growth coefficient for K9 glass, which can attribute to the difference of the material's damage morphology, optical absorption, residual stress near damage site between the two optics glass. The research is very important to choose transparent optical material applied in high power laser.

  8. H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.

    Science.gov (United States)

    Hansen, Klavs R; Hazan, Idit; Shanker, Sreenath; Watt, Stephen; Verhein-Hansen, Janne; Bähler, Jürg; Martienssen, Robert A; Partridge, Janet F; Cohen, Amikam; Thon, Geneviève

    2011-01-06

    Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both multicellular eukaryotes and single-cell model organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic histone marks to the properties of heterochromatin remain largely undefined. Here, we report that silencing of the fission yeast mating-type cassettes, which are located in a well-characterized heterochromatic region, is hardly affected in cells lacking the H3K9 methyltransferase Clr4. We document the existence of a pathway parallel to H3K9me ensuring gene repression in the absence of Clr4 and identify a silencing factor central to this pathway, Clr5. We find that Clr5 controls gene expression at multiple chromosomal locations in addition to affecting the mating-type region. The histone deacetylase Clr6 acts in the same pathway as Clr5, at least for its effects in the mating-type region, and on a subset of other targets, notably a region recently found to be prone to neo-centromere formation. The genomic targets of Clr5 also include Ste11, a master regulator of sexual differentiation. Hence Clr5, like the multi-functional Atf1 transcription factor which also modulates chromatin structure in the mating-type region, controls sexual differentiation and genome integrity at several levels. Globally, our results point to histone deacetylases as prominent repressors of gene expression in fission yeast heterochromatin. These deacetylases can act in concert with, or independently of, the widely studied H3K9me mark to influence gene silencing at heterochromatic loci.

  9. H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.

    Directory of Open Access Journals (Sweden)

    Klavs R Hansen

    Full Text Available Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me and hypoacetylation have been evolutionarily conserved and are found in both multicellular eukaryotes and single-cell model organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic histone marks to the properties of heterochromatin remain largely undefined. Here, we report that silencing of the fission yeast mating-type cassettes, which are located in a well-characterized heterochromatic region, is hardly affected in cells lacking the H3K9 methyltransferase Clr4. We document the existence of a pathway parallel to H3K9me ensuring gene repression in the absence of Clr4 and identify a silencing factor central to this pathway, Clr5. We find that Clr5 controls gene expression at multiple chromosomal locations in addition to affecting the mating-type region. The histone deacetylase Clr6 acts in the same pathway as Clr5, at least for its effects in the mating-type region, and on a subset of other targets, notably a region recently found to be prone to neo-centromere formation. The genomic targets of Clr5 also include Ste11, a master regulator of sexual differentiation. Hence Clr5, like the multi-functional Atf1 transcription factor which also modulates chromatin structure in the mating-type region, controls sexual differentiation and genome integrity at several levels. Globally, our results point to histone deacetylases as prominent repressors of gene expression in fission yeast heterochromatin. These deacetylases can act in concert with, or independently of, the widely studied H3K9me mark to influence gene silencing at heterochromatic loci.

  10. The effect of laser pulse width on laser-induced damage at K9 and UBK7 components surface

    Science.gov (United States)

    Zhou, Xinda; Ba, Rongsheng; Zheng, Yinbo; Yuan, Jing; Li, Wenhong; Chen, Bo

    2015-07-01

    In this paper, we investigated the effects of laser pulse width on laser-induced damage. We measured the damage threshold of K9 glass and UBK7 glass optical components at different pulse width, then analysis pulse-width dependence of damage threshold. It is shown that damage threshold at different pulse width conforms to thermal restriction mechanism, Because of cm size laser beam, defect on the optical component surface leads to laser-induced threshold decreased.

  11. Intensive English Programs in the United States: An Overview of Structure and Mentoring

    Science.gov (United States)

    Thompson, Amy S.

    2013-01-01

    Although English as a second language (ESL) programs are common in the United States, there is surprisingly little research documenting the existing structures and mentoring strategies they use. This lack of research could be partly due to ESL programs' widely varying internal structures (Larson, 1990) and the fact that they are often marginalized…

  12. 75 FR 37771 - Office of Postsecondary Education; Overview Information; Transition Programs for Students with...

    Science.gov (United States)

    2010-06-30

    ...) With mental retardation or a cognitive impairment, characterized by significant limitations in-- (i.... 4. Intergovernmental Review: This program is subject to Executive Order 12372 and the regulations in 34 CFR part 79. Information about Intergovernmental Review of Federal Programs under Executive Order...

  13. Application of Communications Satellite to Educational Development; An Overview of the Washington University Program.

    Science.gov (United States)

    Morgan, Robert P.; And Others

    Selected aspects and results of an interdisciplinary research and education program to examine the potential and problems associated with the use of communication satellites to help meet educational needs in the United States are summarized. The progress of the program to date in four major areas is described: needs analysis, communications…

  14. 75 FR 67705 - Office of Postsecondary Education; Overview Information; Talent Search (TS) Program; Notice...

    Science.gov (United States)

    2010-11-03

    ... rigorous secondary school program of study, postsecondary education enrollment, and postsecondary degree... individuals with potential for education at the postsecondary level and encourage them to complete secondary school and undertake a program of postsecondary education. TS projects publicize the availability of,...

  15. Map Gis-K9 在油田发展建设中的应用

    Institute of Scientific and Technical Information of China (English)

    李金仁

    2016-01-01

    在信息技术时代,油田发展建设过程中也必须提升其决策和业务的信息技术水平。Map GIS-K9 不仅技术成熟,而且二次开发等售后服务能够基于用户实际情况做出科学调整,因此,它在油田发展建设中得到广发应用,也受到用户的广泛认可。从石油地质图编绘系统、油气管道管理系统等方面讨论了Map Gis-K9 在油田发展建设中的应用,希望对促进Map Gis-K9 在油田工程领域中更好地发挥价值,从而促进中国石油领域的进步有积极意义。

  16. Fluorescence and Raman spectra on surface of K9 glass by high fluence ultraviolet laser irradiation at 355 nm

    Science.gov (United States)

    Zhang, Zhen; Huang, Jin; Geng, Feng; Zhou, Xiaoyan; Feng, Shiquan; Ren, Dahua; Cheng, Xinlu; Jiang, Xiaodong; Wu, Weidong; Zheng, Wanguo; Tang, Yongjian

    2013-11-01

    In order to explore the damage mechanisms of K9 glass irradiated by high energy density ultraviolet laser, laser-induced fluorescence and Raman spectra were investigated. Compared the fluorescence spectra of damaged area, undamaged area and sub-damaged area, it can be conclude that the fluorescence spectrum of sub-damaged area is different from the structure of the other two areas. Especially, the main peak of the spectra at 415 nm reveals the unique characteristics of K9 glass. The structure at the sub-damaged area enhances intensity of the Raman scattering spectra. Three peaks of the spectra at about 500 nm and two characteristic peaks at about 550 nm exhibit the characterization of damaged area. A peak of the Raman scattering spectra at 350 nm which related to water can be observed. The relationship between intensity of Raman scattering and laser intensity at 355 nm is investigated by confocal Raman microscopy. At sub-damage area, signal of Raman scattering is rather high and decreased dramatically with respect to energy density. The major band at about 1470 cm-1 sharpened and moved to higher frequency with densification. These phenomena demonstrate that the structure of sub-damaged area has some characterization compared with the damaged area. The investigation of defect induced fluorescence and Raman spectra on surface of K9 glass is important to explore the damage mechanisms of optical materials irradiated by ultraviolet laser irradiation at 355 nm.

  17. Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation.

    Science.gov (United States)

    Lee, Junghee; Hagerty, Sean; Cormier, Kerry A; Kim, Jinho; Kung, Andrew L; Ferrante, Robert J; Ryu, Hoon

    2008-06-15

    Chromatin remodeling is tightly controlled under physiological conditions. Alterations in chromatin structure are involved in the pathogenesis of neuronal systems. We found that the monoallelic deletion of CREB binding protein (CBP) results in the induction of ERG-associated protein with SET domain (ESET) and increases trimethylation of histone H3 (K9) and condensation of pericentromeric heterochromatin structure in neurons. Nested deletion and mutational analysis of the ESET promoter further demonstrated that the Ets-2 transcription factor regulates transcriptional activity of the ESET gene. In CBP+/- mice, Ets-2 occupancy in the ESET promoter DNA was markedly elevated. Our results suggest that CBP is a transcriptional repressor of ESET gene expression by limiting Ets-2 transcriptional activity, while CBP siRNA enhances basal and Ets-2-dependent ESET transcriptional activity. Altered expression of the ESET gene and hypertrimethylation of H3 (K9) correlate with striatal neuron atrophy and dysfunction in CBP+/- mice. These results establish an alternative pathway that loss of CBP leads to the pericentric heterochromatin condensation through ESET expression and trimethylation of H3 (K9).

  18. KEY COMPARISON Final report on APMP international comparison APMP.EM-K9: High voltage AC-DC transfer standards

    Science.gov (United States)

    Wei, Yih-Cheng; Yeh, Hsin-Da

    2010-01-01

    The international key comparison APMP.EM-K9 of AC-DC high voltage transfer standards with 12 participants was carried out from June 2000 to January 2004. This comparison offers the same range and frequencies as BIPM key comparison CCEM-K9, voltages at 500 V and 1000 V, frequency from 1 kHz to 100 kHz. This comparison provides the national metrology institutes (NMIs) of the APMP member economies with an opportunity to link the values of their standards for AC-DC transfer difference to the international reference values. The results of the majority of the participating NMIs show an agreement with the reference value within the associated expanded uncertainty given by the individual NMI. The agreement of the results and the tables of the degree of equivalence of the participants are included. The results have been linked to the key comparison CCEM-K9. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  19. Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote

    Directory of Open Access Journals (Sweden)

    Walter Jörn

    2004-09-01

    Full Text Available Abstract Background In the mouse zygote the paternal genome undergoes dramatic structural and epigenetic changes. Chromosomes are decondensed, protamines replaced by histones and DNA is rapidly and actively demethylated. The epigenetic asymmetry between parental genomes remains at least until the 2-cell stage suggesting functional differences between paternal and maternal genomes during early cleavage stages. Results Here we analyzed the timing of histone deposition on the paternal pronucleus and the dynamics of histone H3 methylation (H3/K4mono-, H3/K4tri- and H3/K9di-methylation immediately after fertilization. Whereas maternal chromatin maintains all types of histone H3 methylation throughout the zygotic development, paternal chromosomes acquire new and unmodified histones shortly after fertilization. In the following hours we observe a gradual increase in H3/K4mono-methylation whereas H3/K4tri-methylation is not present before latest pronuclear stages. Histone H3/K9di-methylation is completely absent from the paternal pronucleus, including metaphase chromosomes of the first mitotic stage. Conclusion Parallel to the epigenetic asymmetry in DNA methylation, chromatin modifications are also different between both parental genomes in the very first hours post fertilization. Whereas methylation at H3/K4 gradually becomes similar between both genomes, H3/K9 methylation remains asymmetric.

  20. Shock induced damage and damage threshold of optical K9 glass investigated by laser-driven shock wave

    Science.gov (United States)

    Song, Yunfei; Yu, Guoyang; Jiang, Lilin; Zheng, Xianxu; Liu, Yuqiang; Yang, Yanqiang

    2011-04-01

    The shock wave driven by short laser pulse is used to study the damage of brittle material K9 glass. The damage morphology of K9 glass surface indicates that the material has experienced different loading modes, respectively, at the central area and the surrounding area of the shock wave. At the central area of shock wave, the wavefront is plane and has a uniform pressure distribution, the material mainly suffers a longitudinal shock pressure; but on the edge the shock wave, the wavefront is approximately spherical, besides longitudinal pressure, transverse tensile stress will emerge inside the material. In the latter case, the damage threshold of the material is much smaller than that in the case of compressing by longitudinal pressure only. According to the relationship between damage area and shock pressure, an experimental method is proposed to measure the damage threshold of materials under shock loading. The damage threshold of K9 glass under spherical shock wave is measured to be about 1.12 GPa; and the damage threshold under plane shock wave is estimated to be between 1.82 and 1.98 GPa. They are much bigger than the damage threshold under static pressure. This method could also be used to measure the damage threshold of other materials when loaded by dynamic pressure.

  1. Transient absorption and luminescence spectra of K9 glass at sub-damage site by ultraviolet laser irradiation

    Science.gov (United States)

    Zhang, Z.; Huang, J.; Geng, F.; Zhou, X. Y.; Feng, S. Q.; Cheng, X. L.; Jiang, X. D.; Wu, W. D.; Zheng, W. G.; Tang, Y. J.

    2014-01-01

    Transient absorption and luminescence spectra at sub-damage site of K9 glass by laser irradiation at 355 nm are presented. The dependence of transient absorption on laser energy and number of pulses was investigated. As the energy density increases to 2.54 and 3.18 J/cm2, the transient absorption intensity reaches to about 0.20 range from 400 to 480 nm. With the increase of number of pulses the process of residual absorption appears, which can be used to explain the fatigue effect of K9 glass. The defects in K9 glass were investigated by fluorescence and Raman spectra. The fluorescence band centered at about 410 nm is attributed to oxygen deficiency centers. The mechanism of two-photon ionization plays a critical role at sub-damage site. Compared to the Raman spectra of pristine site, intensity of Raman spectra is very high at a lower energy density, while it decreased at a higher energy density.

  2. The U.S. Global Change Research Program: An Overview and Perspectives on the FY 1992 Program.

    Science.gov (United States)

    Corell, Robert W.

    1991-05-01

    The U.S. Global Change Research Program (US/GCRP) represents an integrated, government-wide scientific effort designed to document, understand, and predict changes in the global environment as the foundation for national and international policymaking. The President's budget message to the U.S. Congress for FY 1992 proposes spending $1.186 billion on the U.S. Global Change Research Program, an increase of $232 million or almost 25 percent over FY 1991. The budget details a coordinated program of research that involves nine agencies, including the addition in FY 1992 of the several units within the Department of Defense and the Smithsonian Institution.

  3. Overview of Evaluation Methods for R&D Programs. A Directory of Evaluation Methods Relevant to Technology Development Programs

    Energy Technology Data Exchange (ETDEWEB)

    Ruegg, Rosalie [TIA Consulting, Inc., Emeral Isle, NC (United States); Jordan, Gretchen B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2007-03-01

    This document provides guidance for evaluators who conduct impact assessments to determine the “realized” economic benefits and costs, energy, environmental benefits, and other impacts of the Office of Energy Efficiency and Renewable Energy’s (EERE) R&D programs. The focus of this Guide is on realized outcomes or impacts of R&D programs actually experienced by American citizens, industry, and others.

  4. An Overview of the NASA Fundamental Aeronautics Program Subsonic Fixed Wing Project and Ultra High Bypass Partnership Research Goals

    Science.gov (United States)

    Hughes, Christopher E.

    2009-01-01

    An overview of the NASA Fundamental Aeronautics Program (FAP) mission and goals is presented. One of the subprograms under the FAP, the Subsonic Fixed Wing Project (SFW), is the focus of the presentation. The SFW system environmental metrics are discussed, along with highlights of planned, systematic approach to research to reduce the environmental impact of commercial aircraft in the areas of acoustics, fuel burn and emissions. The presentation then focuses on collaborative research being conducted with U.S. Industry on the Ultra High Bypass (UHB) engine cycle, the propulsion cycle selected by the SFW to meet the system goals. The partnerships with General Electric Aviation to investigate Open Rotor propulsion concepts and with Pratt & Whitney to investigate the Geared Turbofan UHB engine are highlighted, including current and planned future collaborative research activities with NASA and each organization.

  5. The Program Manager’s Support System (PMSS). An Executive Overview and System Description,

    Science.gov (United States)

    1987-01-01

    process. The PMSS tool will, when completed, support the program management process in all stages of program nanagement; that is, birth of the...module, developed as a template on LOTUS 1-2-3, is an application of the Constructive Cost Model (COCOMO) developed by B. Boehm. The DSMC SWCE module, a...developed for a specific program office but can be modified for use by others. It is a "template" system designed to operate on a Zenith Z-150 using Lotus 1

  6. Overview of the NASA Lewis component technology program for Stirling power converters

    Science.gov (United States)

    Thieme, Lanny G.; Swec, Diane M.

    1992-01-01

    This paper presents an update on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power program is part of the High Capacity Power element of the NASA Civil Space Technology Initiative. Lewis is also providing technical management of a DOE-funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The Lewis component technology program is coordinated with the primary contract efforts of these projects but is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  7. 76 FR 4330 - American Overseas Research Centers (AORC) Program; Office of Postsecondary Education; Overview...

    Science.gov (United States)

    2011-01-25

    ..., Javanese, Kannada, Kashmiri, Kazakh, Khmer (Cambodian), Kirghiz, Korean, Kurdish (Kurmanji), Kurdish... International Education and Foreign Language Studies: Domestic Programs, of which we intend to allocate $1,400... you. 2. Administrative and National Policy Requirements: We identify administrative and...

  8. An Overview of ARM Program Climate Research Facility Data Quality Assurance

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, Randy A. [University of Oklahoma, Norman; Long, Chuck A. [Pacific Northwest National Laboratory (PNNL); Sisterson, D. L. [Argonne National Laboratory (ANL); Turner, D. [University of Wisconsin; Bahrmann, C. P. [Pennsylvania State University; Christensen, Sigurd W [ORNL; Doty, K. J. [Brookhaven National Laboratory (BNL); Eagan, R. C. [Argonne National Laboratory (ANL); Halter, T. D. [Pacific Northwest National Laboratory (PNNL); Ivey, M. D. [Sandia National Laboratories (SNL); Keck, N. N. [Pacific Northwest National Laboratory (PNNL); Kehoe, Kenneth E. [University of Oklahoma, Norman; Liljegren, J. C. [Argonne National Laboratory (ANL); Macduff, M. C. [Pacific Northwest National Laboratory (PNNL); Mather, J. H. [Pacific Northwest National Laboratory (PNNL); McCord, Raymond A [ORNL; Monroe, Justin W. [University of Oklahoma; Moore, Sean T. [Mission Research and Technical Services; Nitschke, K. L. [Los Alamos National Laboratory (LANL); Orr, B. W. [Argonne National Laboratory (ANL); Perez, Robin C. [Pacific Northwest National Laboratory (PNNL); Perkins, B. D. [Los Alamos National Laboratory (LANL); Richardson, S. J. [Pennsylvania State University; Sonntag, Karen L. [University of Oklahoma, Norman; Voyles, Jimmy W. [Pacific Northwest National Laboratory (PNNL); Wagener, Richard [Brookhaven National Laboratory (BNL)

    2008-10-30

    This report documents key aspects of the Atmospheric Radiation Measurement (ARM) Program's data quality assurance program. Processes described include data archival, display, and distribution, data stream reprocessing, and future directions in ARM data quality checking. A comprehensive, end-to-end data quality assurance program, from instrument siting, to calibration and maintenance, through data quality control and well-documented dissemination, is essential for producing a high-quality research data set. The processes developed over the past 15 years by the ARM Program offer a possible framework for use by other instrumentation-diverse networks, and are offered here to highlight the myriad aspects that go into producing such a data set.

  9. An Overview of the Society of Actuaries and Its Education Programs

    Science.gov (United States)

    Klugman, Stuart; Long, Gena

    2014-01-01

    The Society of Actuaries (SOA) is the world's largest actuarial organization. This article describes the SOA with particular attention paid to its education and qualification processes and resources available for university and college programs.

  10. 2017-04-28_W88 ALT 370 Program Overview(OUO).

    Energy Technology Data Exchange (ETDEWEB)

    Daniels, Vonceil

    2017-04-01

    All major program milestones have been met and the program is executing within budget. The ALT 370 program achieved Phase 6.4 authorization in February of this year. Five component Final Design Reviews (FDRs) have been completed, indicating progress in finalizing the design and development phase of the program. A series of ground-based qualification activities have demonstrated that designs are meeting functional requirements. The first fully functional flight test, FCET-53, demonstrated end-to-end performance in normal flight environments in February. Similarly, groundbased nuclear safety and hostile environments testing indicates that the design meets requirements in these stringent environments. The first in a series of hostile blast tests was successfully conducted in April.

  11. Overview of the NASA Lewis component technology program for Stirling power converters

    Science.gov (United States)

    Thieme, Lanny G.; Swec, Diane M.

    This paper presents an update on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power program is part of the High Capacity Power element of the NASA Civil Space Technology Initiative. Lewis is also providing technical management of a DOE-funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The Lewis component technology program is coordinated with the primary contract efforts of these projects but is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  12. Overview of the TCV tokamak program: scientific progress and facility upgrades

    DEFF Research Database (Denmark)

    Coda, S.; Ahn, J.; Albanese, R.

    2017-01-01

    The TCV tokamak is augmenting its unique historical capabilities (strong shaping, strong electron heating) with ion heating, additional electron heating compatible with high densities, and variable divertor geometry, in a multifaceted upgrade program designed to broaden its operational range with...

  13. Overview of the biomedical and environmental programs at the Oak Ridge National Laboratory. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Pfuderer, H.A.; Moody, J.B. (comps.)

    1981-07-01

    Separate abstracts were prepared for each of the 6 chapters presented by the six divisions involved in the Biomedical and Environmental Sciences Program at Oak Ridge National Laboratory. The introduction is not covered by an abstract and deals with the environmental, health and safety considerations of energy technology decisions, the major initiatives now being taken by these 6 divisions, and recent major accomplishments in the biomedical and environmental science program. (KRM)

  14. Overview of the SAMSI year-long program on Statistical, Mathematical and Computational Methods for Astronomy

    Science.gov (United States)

    Jogesh Babu, G.

    2017-01-01

    A year-long research (Aug 2016- May 2017) program on `Statistical, Mathematical and Computational Methods for Astronomy (ASTRO)’ is well under way at Statistical and Applied Mathematical Sciences Institute (SAMSI), a National Science Foundation research institute in Research Triangle Park, NC. This program has brought together astronomers, computer scientists, applied mathematicians and statisticians. The main aims of this program are: to foster cross-disciplinary activities; to accelerate the adoption of modern statistical and mathematical tools into modern astronomy; and to develop new tools needed for important astronomical research problems. The program provides multiple avenues for cross-disciplinary interactions, including several workshops, long-term visitors, and regular teleconferences, so participants can continue collaborations, even if they can only spend limited time in residence at SAMSI. The main program is organized around five working groups:i) Uncertainty Quantification and Astrophysical Emulationii) Synoptic Time Domain Surveysiii) Multivariate and Irregularly Sampled Time Seriesiv) Astrophysical Populationsv) Statistics, computation, and modeling in cosmology.A brief description of each of the work under way by these groups will be given. Overlaps among various working groups will also be highlighted. How the wider astronomy community can both participate and benefit from the activities, will be briefly mentioned.

  15. Overview of results from phase I of the Beam Energy Scan program at RHIC

    Directory of Open Access Journals (Sweden)

    McDonald Daniel

    2015-01-01

    Full Text Available The first phase of the Beam Energy Scan (BES program at the Relativistic Heavy Ion Collider (RHIC was successfully completed during the years 2010, 2011 and 2014, with Au+Au collisions at center-of-mass energies (√sNN of 7.7, 11.5, 14.5, 19.6, 27, and 39 GeV. The BES has three distinct goals: search for the turning off of the signatures of the Quark Gluon Plasma (QGP, search for the first-order phase transition, and search for the critical point. We report several interesting results that address each of these goals of the BES program.

  16. The North American Regional Climate Change Assessment Program: Overview of Phase I Results

    Energy Technology Data Exchange (ETDEWEB)

    Mearns, L. O.; Arritt, R.; Biner, S.; Bukovsky, Melissa; McGinnis, Seth; Sain, Steve; Caya, Daniel; Correia Jr., James; Flory, Dave; Gutowski, William; Takle, Gene; Jones, Richard; Leung, Lai-Yung R.; Moufouma-Okia, Wilfran; McDaniel, Larry; Nunes, A.; Qian, Yun; Roads, J.; Sloan, Lisa; Snyder, Mark A.

    2012-09-20

    The North American Regional Climate Change Assessment Program is an international effort designed to systematically investigate the uncertainties in regional scale projections of future climate and produce high resolution climate change scenarios using multiple regional climate models (RCMs) nested within atmosphere ocean general circulation models (AOGCMs) forced with the A2 SRES scenario, with a common domain covering the conterminous US, northern Mexico, and most of Canada. The program also includes an evaluation component (Phase I) wherein the participating RCMs are nested within 25 years of NCEP/DOE global reanalysis II. The grid spacing of the RCM simulations is 50 km.

  17. Student Research in Asia Overview of 2007 Student-Faculty Fellows Program

    Directory of Open Access Journals (Sweden)

    Van Symons

    2008-09-01

    Full Text Available During the summer of 2007, mentors from fourteen different small college/universities in North America, each with from two to five students, conducted undergraduate research in East and Southeast Asia as part of the 9th annual Student-Faculty Fellows Program. Each project was generously funded by the Freeman Foundation and administered by ASIANetwork.

  18. 75 FR 49484 - Office of Postsecondary Education; Overview Information; Jacob K. Javits Fellowship Program...

    Science.gov (United States)

    2010-08-13

    ... education. The selected fields in the arts are: Creative writing, music performance, music theory, music...: September 30, 2010. Deadline for Transmittal of the Free Application for Federal Student Aid (FAFSA... purpose of the Jacob K. Javits (JKJ) Fellowship Program is to award fellowships to eligible students...

  19. 75 FR 28789 - Office of Innovation and Improvement; Overview Information; Charter Schools Program (CSP) Grants...

    Science.gov (United States)

    2010-05-24

    ... of the Social Security Act, or (iv) data on children eligible to receive medical assistance under the Medicaid program under Title XIX of the Social Security Act, or (v) an alternate method that combines or... to participate in the meeting (e.g., interpreting service, assistive listening device, or...

  20. Gang Prevention: An Overview of Research and Programs. Juvenile Justice Bulletin

    Science.gov (United States)

    Howell, James C.

    2010-01-01

    This bulletin presents research on why youth join gangs and how a community can build gang prevention and intervention services. The author summarizes recent literature on gang formation and identifies promising and effective programs for gang prevention. The following are some key findings: (1) Youth join gangs for protection, enjoyment, respect,…

  1. Key Implementation Considerations for Executing Evidence-Based Programs: Project Overview. ASPE Research Brief

    Science.gov (United States)

    US Department of Health and Human Services, 2013

    2013-01-01

    In April 2011, the U.S. Department of Health and Human Services (HHS) Office of the Assistant Secretary for Planning and Evaluation (ASPE) hosted a Forum, Emphasizing Evidence-Based Programs for Children and Youth, to convene the nation's leading practitioners and researchers with experience using and evaluating an array of evidence-based…

  2. 24 CFR 291.510 - Overview of the GNND Sales Program.

    Science.gov (United States)

    2010-04-01

    ... Program enables a full-time law enforcement officer, teacher, or firefighter/emergency medical technician... the law enforcement officer, teacher, or firefighter/emergency medical technician finances the home... officers, teachers, and firefighters/emergency medical technicians prior to listing the properties for...

  3. 75 FR 8316 - Office of Postsecondary Education; Overview Information; Erma Byrd Scholarship Program; Notice...

    Science.gov (United States)

    2010-02-24

    ... Rulemaking Requirements. Under the Administrative Procedure Act (APA) (5 U.S.C. 553) and section 437 of the... provisions of section 553 of the APA and section 437 of GEPA do not apply to this program. IV. Application... of the application package in an accessible format (e.g., braille, large print, audiotape, or...

  4. Toxicity characterization of environmental chemicals by the US National Toxicology Program: an overview.

    Science.gov (United States)

    Chhabra, Rajendra S; Bucher, John R; Wolfe, Mary; Portier, Christopher

    2003-08-01

    The US National Toxicology Program (NTP) is an interagency program whose mission is to evaluate agents of public health concern by developing and applying the tools of modern toxicology and molecular biology. Chemicals substances or physical agents selected for toxicology and carcinogenesis evaluations by the NTP are usually studied in a series of subacute (14-day exposure), subchronic (90-day exposure) and chronic (2-year exposure) studies in rodents. The NTP has published more than 500 reports of the findings and conclusions from its toxicology and carcinogenesis studies. In more specialized studies, the NTP also evaluates adverse effects on the structure and function of the immune, reproductive, nervous, and respiratory systems. The program attempts to evaluate and appropriately incorporate new technologies to improve the way we study the toxicity of chemicals. For example, the program has extensively evaluated several transgenic mouse models for their potential use as short-term cancer screens and has been a full participant in an international effort to examine their usefulness in pharmaceutical registration. Toxicogenomics, an emerging scientific field that examines the expression of thousands of genes simultaneously in response to chemical exposure, holds promise for future application to better understand the underlying mechanisms of chemical toxicity. A number of public health issues being addressed by the NTP are not only of national importance but also have global impact, such as the potential for endocrine disruptors to influence development and carcinogenesis and the safety of herbal medicines and dietary supplements. The program participates in the preparation of national and international toxicity testing guidelines and the findings from NTP studies are widely used for risk assessments by international organizations and federal agencies. The NTP maintains databases that contain toxicity, and health and safety information on a large number of

  5. Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Donglin; Qu, Xiying; Li, Lin; Zhou, Xin; Liu, Sijie; Lin, Shiguan; Wang, Pengfei; Liu, Shaohui; Kong, Chuijin; Wang, Xiaohui; Liu, Lin; Zhu, Huanzhang, E-mail: hzzhu@fudan.edu.cn

    2013-06-05

    Understanding the mechanism of HIV-1 latency is crucial to eradication of the viral reservoir in HIV-1-infected individuals. However, the role of histone methyltransferase (HMT) G9a-like protein (GLP) in HIV-1 latency is still unclear. In the present work, we established four clonal cell lines containing HIV-1 vector. We found that the integration sites of most clonal cell lines favored active gene regions. However, we also observed hypomethylation of CpG of HIV 5′LTR in all four clonal cell lines. Additionally, 5′-deoxy-5′-methylthioadenosine (MTA), a broad-spectrum histone methyltransferase inhibitor, was used to examine the role of histone methylation in HIV-1 latency. MTA was found to decrease the level of H3K9 dimethylation, causing reactivation of latent HIV-1 in C11 cells. GLP knockdown by small interfering RNA clearly induced HIV-1 LTR expression. Results suggest that GLP may play a significant role in the maintenance of HIV-1 latency by catalyzing dimethylation of H3K9. - Highlights: ► We have established an in vitro model of HIV-1 latency. ► The integration sites of most clonal cell lines favor in active gene regions. ► Hypomethylation occurs in CpG islands of HIV 5′LTR in all four clonal cell lines. ► MTA can reactivate latent HIV-1 by decreasing the level of H3K9 me2 in C11 cells. ► HMT GLP may play a significant role in the maintenance of HIV-1 latency.

  6. Process of consumer energy conservation: A conceptual framework for program analysis. Energy conservation programs for consumers: A comparative overview of findings

    Energy Technology Data Exchange (ETDEWEB)

    Joerges, B.; Olsen, M.E.; Mueller, H.

    1983-01-01

    In the first volume of the CECP Technical Reports Series two studies are combined: one version of the initial conceptual framework guiding CECP-research, and a condensed comparative analysis of the national findings in phase I of our research. Since the two papers originally stood on their own, some figures, tables, introductory remarks, and explications of terms are repeated. The first part, on the process of consumer energy conservation, is one of several formulations of a conceptual and analytical perspective for the evaluation of energy conservation policies and programs. The second part, on the comparison of conservation policies and programs, summarizes the findings of studies in the eight countries included. This cross-national overview should be understood as an attempt to identify common themes and trends as well as characteristic differences in conservation policies and programs directed at private end-users of energy. It should not be read as a substitute but rather an invitation to refer back to the original studies contained in this series.

  7. Target salt 2025: a global overview of national programs to encourage the food industry to reduce salt in foods.

    Science.gov (United States)

    Webster, Jacqui; Trieu, Kathy; Dunford, Elizabeth; Hawkes, Corinna

    2014-08-21

    Reducing population salt intake has been identified as a priority intervention to reduce non-communicable diseases. Member States of the World Health Organization have agreed to a global target of a 30% reduction in salt intake by 2025. In countries where most salt consumed is from processed foods, programs to engage the food industry to reduce salt in products are being developed. This paper provides a comprehensive overview of national initiatives to encourage the food industry to reduce salt. A systematic review of the literature was supplemented by key informant questionnaires to inform categorization of the initiatives. Fifty nine food industry salt reduction programs were identified. Thirty eight countries had targets for salt levels in foods and nine countries had introduced legislation for some products. South Africa and Argentina have both introduced legislation limiting salt levels across a broad range of foods. Seventeen countries reported reductions in salt levels in foods-the majority in bread. While these trends represent progress, many countries have yet to initiate work in this area, others are at early stages of implementation and further monitoring is required to assess progress towards achieving the global target.

  8. Target Salt 2025: A Global Overview of National Programs to Encourage the Food Industry to Reduce Salt in Foods

    Directory of Open Access Journals (Sweden)

    Jacqui Webster

    2014-08-01

    Full Text Available Reducing population salt intake has been identified as a priority intervention to reduce non-communicable diseases. Member States of the World Health Organization have agreed to a global target of a 30% reduction in salt intake by 2025. In countries where most salt consumed is from processed foods, programs to engage the food industry to reduce salt in products are being developed. This paper provides a comprehensive overview of national initiatives to encourage the food industry to reduce salt. A systematic review of the literature was supplemented by key informant questionnaires to inform categorization of the initiatives. Fifty nine food industry salt reduction programs were identified. Thirty eight countries had targets for salt levels in foods and nine countries had introduced legislation for some products. South Africa and Argentina have both introduced legislation limiting salt levels across a broad range of foods. Seventeen countries reported reductions in salt levels in foods—the majority in bread. While these trends represent progress, many countries have yet to initiate work in this area, others are at early stages of implementation and further monitoring is required to assess progress towards achieving the global target.

  9. Pre-analytical variables of circulating cell-free nucleosomes containing 5-methylcytosine DNA or histone modification H3K9Me3

    DEFF Research Database (Denmark)

    Rasmussen, Louise; Herzog, Marielle; Rømer, Eva

    2016-01-01

    Aim: To evaluate pre-analytical variables of circulating cell-free nucleosomes containing 5-methylcytosine DNA (5mC) or histone modification H3K9Me3 (H3K9Me3). Materials and methods: Six studies were designed to assess the possible influence of pre-analytical variables. Study 1: influence of stasis...

  10. Alternative response technology program for the Deepwater Horizon in the Gulf of Mexico - an overview

    Energy Technology Data Exchange (ETDEWEB)

    Cortez, Michael J.; Rowe, Hunter G. [BP - Gulf Coast Restoration (United States)], email: michael.cortez@bp.com

    2011-07-01

    The innovative approach utilized by the Alternative Response Technology (ART) Program for the MC252 Deepwater Horizon response in the Gulf of Mexico during 2010 was presented in this paper. The ART program is authorized by the Unified Area Command. This paper focuses on the spill response technologies that were implemented offshore, near shore and on-shore, and covers technologies related to booming, skimming, separation, sand cleaning, surveillance and detection. A process was designed and implemented for capturing ideas real time, which leveraged the public's ingenuity and entrepreneurial spirit. About 120,000 individual ideas were submitted by the public globally from more than 100 countries. About 40,000 of these ideas were related to addressing the spill response. There are about 100 new technologies related to spill response that were formally evaluated and/or field tested, and approximately 25 of those tested were successfully implemented across the spill response area.

  11. Program director`s overview report for the Office of Health & Environmental Research

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, D. [ed.

    1994-02-01

    LBL performs basic and applied research and develops technologies in support of the Office of Health and Environmental Research`s mission to explore and mitigate the long-term health and environmental consequences of energy use and to advance solutions to major medical challenges. The ability of the Laboratory to engage in this mission depends upon the strength of its core competencies. In addition, there are several key capabilities that are cross-cutting, or underlie, many of the core competencies. Attention is focused on the following: Facilities and resources; research management practices; research in progress; program accomplishments and research highlights; program orientation; work for non-OHER organizations DOE; critical issues; and resource orientation.

  12. Overview of the U.S. Department of Energy Formerly Utilized Sites Remedial Action Program - 12189

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Christopher [U.S. Department of Energy Office of Legacy Management, Washington, DC (United States); Kothari, Vijendra [U.S. Department of Energy Office of Legacy Management, Morgantown, West Virginia (United States); Starr, Ken [U.S. Department of Energy Office of Legacy Management, Westminster, Colorado (United States); Gillespie, Joey; Widdop, Michael [S.M. Stoller Corporation, Contractor for the U.S. Department of Energy Office of Legacy Management, Grand Junction, Colorado (United States)

    2012-07-01

    The U.S. Department of Energy (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to address residual radiological contamination at sites where work was performed for the Manhattan Engineer District and U.S. Atomic Energy Commission. Initially, FUSRAP activities began with a records search for sites that had the potential to contain residual radiological contamination; 46 sites were identified that were eligible for and required remediation. Remedial action began in 1979. In 1997, Congress assigned responsibility for the remediation of FUSRAP sites to the U.S. Army Corps of Engineers (USACE). DOE retains responsibility for determining if sites are eligible for FUSRAP remediation and for providing long-term surveillance and maintenance (LTS and M) of remediated FUSRAP sites. DOE LTS and M activities are designed to ensure that FUSRAP sites remain protective of human health and the environment and to preserve knowledge regarding FUSRAP sites. Additional elements include eligibility determinations, transition of remediated sites from USACE to DOE, LTS and M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close coordination with USACE and regulators to ensure there is no loss of protectiveness when sites transition to DOE for LTS and M. Over the life of the FUSRAP program from 1974 to the present, DOE's primary mission and responsibility has been to ensure that FUSRAP sites remain protective of human health and the environment. In fulfilling this mission, the DOE program includes the following key elements: eligibility determinations, transition of remediated sites from USACE to DOE, LTS and M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close communication stakeholders as well as state and federal regulators

  13. Joint Service Chemical and Biological Defense Program FY 08-09 Overview

    Science.gov (United States)

    2007-10-01

    detoxifying component. These include photocatalysts, nanoceramic -supported enzymes, and biocides/sporocides. Researchers will also pursue technologies...oil, and lubricants (POLs)—significant capability improvements for the armor community. The JSLIST Block II Glove Upgrade (JB2GU) provides protection...Strategy, and Support PM Project manager POL petroleum, oil, and lubricants POM Program objective memorandum PPE personal protective equipment R&D

  14. An overview of PETC`s gas-to-liquids technology R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Stiegel, G.J.; Bose, A.C.; Srivastava, R.D.

    1995-04-01

    The overall goal of the Gas-to-Liquids Program at the U.S. Department of Energy`s Pittsburgh Energy Technology Center (PETC) is to develop technologies for the production of hydrocarbon fuels and premium chemicals from light alkane gases. PETC`s current Gas-to-Liquids Program comprises the development of four primary advanced conversion technologies, namely, partial oxidation, oxidative coupling, oxyhydrochlorination, and novel conversion processes. Based on the current state of development, it can be concluded that, in the near future, one or more of these technologies will reach proof-of-concept demonstration. Oxyhydrochlorination is the most advanced direct conversion technology, and the synthesis of lower cost methyl chloride from natural gas would impact several commercial technologies that utilize methyl chloride as an intermediate to high value products. Technology development for the partial oxidation of methane to synthesis gas using ceramic membranes could result in significant savings in synthesis gas generation costs by eliminating the air separation plant and replacing the conventional synthesis gas generation loop. A mixed conducting membrane has been developed, and sustained proof-of-principle tests have shown commercially relevant methane conversions and CO selectivities. A multichannel reactor development and demonstration program has been proposed.

  15. An overview of Compassionate Use Programs in the European Union member states.

    Science.gov (United States)

    Balasubramanian, Gayathri; Morampudi, Suman; Chhabra, Pankdeep; Gowda, Arun; Zomorodi, Behsad

    2016-11-01

    The past decade witnessed rapid development of novel drugs and therapeutic biological agents. The marketing authorization for novel therapies is often time consuming and distressing for patients. Earlier clinical trials were the only way to access new drugs under development. However, not every patient meets the enrolment criteria, and participation is difficult for patients with life-threatening, long-lasting or seriously debilitating diseases like rare diseases. Early access programs like "Compassionate Use Program (CUP)" have generated alternative channels for such patients. The European Medical Agency provides regulations and recommendations for compassionate use, upon which every European Union (EU) member state has developed its own rules and regulations. Despite previous reviews and studies, the available information is limited and gaps exist. This literature review explores CUP in 28 EU member states. Data was collected through literature review and use of country-specific search terms from the healthcare domain. Data sources were not limited to databases and articles published in journals, but also included grey literature. The results implied that CUP was present in 20 EU member states (71%). Of 28 EU states, 18 (∼64%) had nationalized regulations and processes were well-defined. Overall, this review identified CUP and its current status and legislation in 28 EU member states. The established legislation for CUP in the EU member states suggest their willingness to adopt processes that facilitate earlier and better access to new medicines. Further research and periodic reviews are warranted to understand the contemporary and future regulatory trends in early access programs.

  16. The NIH Countermeasures Against Chemical Threats Program: overview and special challenges.

    Science.gov (United States)

    Jett, David A

    2016-06-01

    Intentional exposures to toxic chemicals can stem from terrorist attacks, such as the release of sarin in the Tokyo subway system in 1995, as well as from toxic industrial accidents that are much more common. Developing effective medical interventions is a critical component of the overall strategy to overcome the challenges of chemical emergencies. These challenges include the rapid and lethal mode of action of many toxic chemicals that require equally fast-acting therapies, the large number of chemicals that are considered threats, and the diverse demographics and vulnerabilities of those who may be affected. In addition, there may be long-term deleterious effects in survivors of a chemical exposure. Several U.S. federal agencies are invested in efforts to improve preparedness and response capabilities during and after chemical emergencies. For example, the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) Program supports investigators who are developing therapeutics to reduce mortality and morbidity from chemical exposures. The program awards grants to individual laboratories and includes contract resource facilities and interagency agreements with Department of Defense laboratories. The range of high-quality research within the NIH CounterACT Program network is discussed.

  17. Overview of the 2006-2008 JOGMEC/NRCan/Aurora Mallik Gas Hydrate Production Test Program

    Science.gov (United States)

    Yamamoto, K.; Dallimore, S. R.

    2008-12-01

    During the winters of 2007 and 2008 the Japan Oil, Gas and Metals National Corporation (JOGMEC) and Natural Resources Canada (NRCan), with Aurora Research Institute as the operator, carried out an on-shore gas hydrate production test program at the Mallik site, Mackenzie Delta, Northwest Territories, Canada. The prime objective of the program was to verify the feasibility of depressurization technique by drawing down the formation pressure across a 12m perforated gas hydrate bearing section. This project was the second full scale production test at this site following the 2002 Japex/JNOC/GSC et al Mallik research program in which seven participants organizatinos from five countries undertook a thermal test using hot water circulation Field work in 2007 was devoted to establishing a production test well, installing monitoring devices outside of casing, conducting base line geophysical studies and undertaking a short test to gain practical experience prior to longer term testing planned for 2008 . Hydrate-dissociated gas was produced to surface by depressurization achieved by lowering the fluid level with a dowhole pump. However, the operation was terminated 60 hours after the start of the pumping mainly due to sand production problems. In spite of the short period (12.5 hours of ellapsed pumping time), at least 830m3 of the gas was produced and accumulated in the borehole. Sand screens were installed across the perforated interval at the bottom hole for the 2008 program to overcome operational problems encountered in 2007 and achieve sustainable gas production. Stable bottom hole flowing pressures were successfully achieved during a 6 day test with continuous pump operation. Sustained gas production was achieved with rates between 2000- 4000m3/day and cummulative gas volume in the surface of approximately 13,000m3. Temperature and pressure data measured at the bottom hole and gas and water production rates gave positive evidence for the high efficiency of gas

  18. Overview of the University of Washington's Pre-Major in Astronomy Program

    Science.gov (United States)

    Haggard, Daryl; Pre-Major in Astronomy Program

    2015-01-01

    The fraction of science PhDs awarded to women, African American, Latino, and other minority students is currently far smaller than the fraction of the general population that these groups constitute (NSF 06-320, NSF 04-317). The future of Physics and Astronomy in the United States depends on recruiting and retaining these students in STEM majors and careers (Norman et al., 2009). The greatest obstacles for persistence in science reported by students are loss of interest, intimidation, poor advising, and lack of acceptance (Seymour & Hewitt, 1997). In 2005, a group of University of Washington graduate students created the Pre-Major in Astronomy Program (Pre-MAP) to connect incoming undergraduate students to authentic research experiences as a means of recruiting and retaining them in STEM. Pre-MAP was one of only 13 initiatives supported by the President's Diversity Appraisal Implementation Fund and has proved to be one of its greatest success stories. At its core is a 10-week seminar in which undergraduates learn astronomical research techniques (e.g., computing, data analysis, documentation, statistics, and literature review) and apply them to projects conducted in small groups, under the supervision of faculty and postdocs. Now in its tenth year, Pre-MAP has engaged more than 100 undergraduates — its ongoing success has made it a model for similar programs at UW and other universities.I will outline the beginnings, funding streams, and structure of this long-running diversity program. The Pre-MAP sessions that follow will highlight our best practices and lessons learned, and feature first-hand accounts from several of our fantastic Pre-MAP alumni.

  19. National Swine Genetic Improvement: An overview of essential program components and organizational structure needed for success

    Institute of Scientific and Technical Information of China (English)

    John; MABRY

    2005-01-01

    The swine industry in China is a thrivingand evolving industry that has shown phenome-nal growth over the past10years.Newand mod-ern swine farms have been started in locationsacross the country.Genetics has been importedfrom many different countries in an effort to up-grade the quality and efficiency of the traditionalbreeds of swine.But to insure long term successand viability in a worldwide competitive industrysuch as pork,there is need for a National SwineGenetic Improvement Program.This programneeds to ...

  20. Overview of CMC Development Activities in NASA's Ultra-Efficient Engine Technology (UEET) Program

    Science.gov (United States)

    Brewer, Dave

    2001-01-01

    The primary objective of the UEET (Ultra-Efficient Engine Technology) Program is to address two of the most critical propulsion issues: performance/efficiency and reduced emissions. High performance, low emissions engine systems will lead to significant improvement in local air quality, minimum impact on ozone depletion and level to an overall reduction in aviation contribution to global warming. The Materials and Structures for High Performance project will develop and demonstrate advanced high temperature materials to enable high-performance, high efficiency, and environmentally compatible propulsion systems.

  1. Overview of the Mexican-American cooperative program at the Cerro Prieto geothermal field

    Science.gov (United States)

    Lippmann, M. J.; Zelwer, R.

    1982-09-01

    The Lawrence Berkeley Laboratory is coordinating the US technical activities being carried out at Cerro Prieto under a five-year agreement between the US Department of Energy and the Comission Federal de Electricidad de Mexico. This agreement, signed in July 1977, is expected to expire in July 1982. Efforts are being made to continue some of the research beyond the formal termination of the agreement. A description of the program, which involves studies of geology, geophysics, hydrodynamics, subsidence, geothermal wells and reservoirs, and aquifers, is discussed.

  2. Overview 2010 of ARL Program on Network Science for Human Decision Making.

    Science.gov (United States)

    West, Bruce J

    2011-01-01

    The Army Research Laboratory program on the Network Science of Human Decision Making brings together researchers from a variety of disciplines to work on a complex research problem that defies confinement within any single discipline. Consequently, new and rewarding solutions have been obtained for a problem of importance to society and the Army, that being, the human dimension of complex networks. This program investigates the basic research foundation of a science of networks supporting the linkage between the cognitive and social domains as they relate to human decision making. The research strategy extends recent methods of non-equilibrium statistical physics to non-stationary, renewal stochastic processes characteristic of the interactions among nodes in complex networks. The theoretical analyses of complex networks, although mathematically rigorous, often elude analytic solutions and require simulation and computation to analyze the underlying dynamic process. The information transfer between two complex networks is calculated using the principle of complexity management as well as direct numerical calculation of the decision making model developed within the project.

  3. OVERVIEW 2010 OF ARL PROGRAM ON NETWORK SCIENCE FOR HUMAN DECISION MAKING

    Directory of Open Access Journals (Sweden)

    Bruce J West

    2011-11-01

    Full Text Available The Army Research Laboratory program on the Network Science of Human Decision Making brings together researchers from a variety of disciplines to work on a complex research problem that defies confinement within any single discipline. Consequently, new and rewarding solutions have been obtained for a problem of importance to society and the Army, that being, the human dimension of complex networks. This program investigates the basic research foundation of a science of networks supporting the linkage between the cognitive and social domains as they relate to human decision making. The research strategy extends recent methods of non-equilibrium statistical physics to non-stationary, renewal stochastic processes characteristic of the interactions among nodes in complex networks. The theoretical analyses of complex networks, although mathematically rigorous, often elude analytic solutions and require simulation and computation to analyze the underlying dynamic process. The information transfer between two complex networks is calculated using the Principle of Complexity Management (PCM as well as direct numerical calculation of the decision making model (DMM developed within the project.

  4. Overview of recent results from the Beam Energy Scan program in the STAR experiment

    Science.gov (United States)

    Lipiec, Andrzej

    2016-09-01

    It is believed, that shortly after the Big Bang the Universe existed in the state of the Quark Gluon Plasma, where quarks and gluons act as quasi-free particles. During relativistic heavy ion collisions this state of matter can be reproduced. Quantum Chromo-Dynamics (QCD) calculations show possible existence of the critical point and the 1st order phase transition between hadron gas and QGP. The Relativistic Heavy Ion Collider's (RHIC) program called Beam Energy Scan (BES) was developed for experimental verification of above QCD predictions. Within this program the Solenoidal Tracker At RHIC (STAR) experiment gathered data from gold-gold collisions at √sNN = 7.7, 11.5, 14.5, 19.6, 27, 39, 62.4 and 200 GeV. This data are analysed by STAR Collaboration in search for answers to questions concerning the nuclear matter phases, namely: what is the collision energy for the onset of the QGP formation? What is the nature of a phase transition between QGP and hadron gas? Is there a critical point and if yes, where is it situated? In this proceedings a few of the latest STAR results that address these questions are presented.

  5. H0LiCOW - I. H0 Lenses in COSMOGRAIL's Wellspring: program overview

    Science.gov (United States)

    Suyu, S. H.; Bonvin, V.; Courbin, F.; Fassnacht, C. D.; Rusu, C. E.; Sluse, D.; Treu, T.; Wong, K. C.; Auger, M. W.; Ding, X.; Hilbert, S.; Marshall, P. J.; Rumbaugh, N.; Sonnenfeld, A.; Tewes, M.; Tihhonova, O.; Agnello, A.; Blandford, R. D.; Chen, G. C.-F.; Collett, T.; Koopmans, L. V. E.; Liao, K.; Meylan, G.; Spiniello, C.

    2017-07-01

    Strong gravitational lens systems with time delays between the multiple images allow measurements of time-delay distances, which are primarily sensitive to the Hubble constant that is key to probing dark energy, neutrino physics and the spatial curvature of the Universe, as well as discovering new physics. We present H0LiCOW (H0 Lenses in COSMOGRAIL's Wellspring), a program that aims to measure H0 with species to 0.2 (1σ uncertainties) when combined with current cosmic microwave background (CMB) experiments. These are, respectively, a factor of ˜15, ˜2 and ˜1.5 tighter than CMB alone. Our data set will further enable us to study the stellar initial mass function of the lens galaxies, and the co-evolution of supermassive black holes and their host galaxies. This program will provide a foundation for extracting cosmological distances from the hundreds of time-delay lenses that are expected to be discovered in current and future surveys.

  6. Joint Task Force on Undergraduate Physics Programs (J-TUPP): Overview and Major Findings

    Science.gov (United States)

    Heron, Paula

    2016-03-01

    The Joint Task Force on Undergraduate Physics Programs (JTUPP) was formed in response to growing awareness in the physics community that physics majors pursue a wide range of careers after graduation, with very few ending up in academia. The task force is charged with identifying the skills and knowledge that undergraduate physics degree holders should possess to be well prepared for a diverse set of careers, and providing guidance for physicists considering revising the undergraduate curriculum to improve the education of a diverse student population. Task force members represent large and small universities, professional societies, and industry, and have expertise in a broad range of areas including entrepreneurship, physics education research and systemic change in education. We reviewed employment data, surveys of employers, and reports generated by other disciplines. We also met with physicists in selected industries to get their views on the strengths and weaknesses of physics graduates, commissioned a series of interviews with recent physics graduates employed in the private sector, and identified exemplary programs that ensure that all of their students are well prepared to pursue a wide range of career paths. The findings and recommendations will be summarized.

  7. Advanced Earth-to-orbit propulsion technology program overview: Impact of civil space technology initiative

    Science.gov (United States)

    Stephenson, Frank W., Jr.

    1988-01-01

    The NASA Earth-to-Orbit (ETO) Propulsion Technology Program is dedicated to advancing rocket engine technologies for the development of fully reusable engine systems that will enable space transportation systems to achieve low cost, routine access to space. The program addresses technology advancements in the areas of engine life extension/prediction, performance enhancements, reduced ground operations costs, and in-flight fault tolerant engine operations. The primary objective is to acquire increased knowledge and understanding of rocket engine chemical and physical processes in order to evolve more realistic analytical simulations of engine internal environments, to derive more accurate predictions of steady and unsteady loads, and using improved structural analyses, to more accurately predict component life and performance, and finally to identify and verify more durable advanced design concepts. In addition, efforts were focused on engine diagnostic needs and advances that would allow integrated health monitoring systems to be developed for enhanced maintainability, automated servicing, inspection, and checkout, and ultimately, in-flight fault tolerant engine operations.

  8. An Overview of the Los Alamos Program on Asteroid Mitigation by a Nuclear Explosion

    Science.gov (United States)

    Weaver, R.; Gisler, G. R.; Plesko, C. S.; Ferguson, J.

    2014-12-01

    Los Alamos National Laboratory is standing up a new program to address the mitigation of a potentially hazardous objects (PHO) by using nuclear explosives. A series of efforts at Los Alamos have been working this problem for the last few years in an informal fashion. We now have a funded program to dedicate time to this important mission. The goal of our project is to study the effectiveness of using a nuclear explosive to mitigate (alter orbit or destroy) an PHO on an Earth crossing path. We are also pursuing studies of impact hazards should the international leadership decide not to organize a mission for active mitigation of a PHO. Such impact hazards are characterized as local, regional or global. Impact hazards include: a direct hit in an urban area (potentially catastrophic but highly unlikely); the generation a significant tsunami from an ocean impact close to a coastline and regional and global effects from medium to large impactors. Previous studies at Los Alamos have looked at 2D and 3D simulations in the deep ocean from large bolides, as well as impacts that have global consequences. More recent work has included radiation-hydrodynamic simulations of momentum transfer (and enhancement) from a low energy (10 kt) stand-off source, as well as surface and subsurface high energy explosions (100 kt - 10 Mt) for example PHOs. The current program will carefully look at two main aspects of using a standoff nuclear source: 1) a computational study for the optimum height-of-burst (HOB) of a stand-off burst using our best energy coupling techniques for both neutrons and x-rays; and 2) as a function of the nuclear energy produced and the HOB what is the optimum energy field: neutrons or x-rays. This team is also working with NNSA and NASA Goddard to compare numerical results for these complicated simulations on a well defined series of test problems involving both kinetic impactors and stand-off nuclear energy sources. Results will be shown by the co-authors on

  9. U.S. Department of Energy's Regional Carbon Sequestration Partnership Program: Overview

    Science.gov (United States)

    Litynski, J.; Plasynski, S.; Spangler, L.; Finley, R.; Steadman, E.; Ball, D.; Nemeth, K.J.; McPherson, B.; Myer, L.

    2009-01-01

    The U.S. Department of Energy (DOE) has formed a nationwide network of seven regional partnerships to help determine the best approaches for capturing and permanently storing gases that can contribute to global climate change. The Regional Carbon Sequestration Partnerships (RCSPs) are tasked with determining the most suitable technologies, regulations, and infrastructure for carbon capture, transport, and storage in their areas of the country and parts of Canada. The seven partnerships include more than 350 state agencies, universities, national laboratories, private companies, and environmental organizations, spanning 42 states, two Indian nations, and four Canadian provinces. The Regional Partnerships initiative is being implemented in three phases: ???Characterization Phase (2003-2005): The objective was to collect data on CO2 sources and sinks and develop the human capital to support and enable future carbon sequestration field tests and deployments. The completion of this Phase was marked by release of the Carbon Sequestration Atlas of the United States and Canada-Version 1 which included a common methodology for capacity assessment and reported over 3,000GT of storage capacity in saline formations, depleted oil and gas fields, and coal seams.???Validation Phase (2005-2009): The objective is to plan and implement small-scale (1??million tons of CO2) Carbon Capture and Storage (CCS) projects, which will demonstrate that large volumes of CO2 can be injected safely, permanently, and economically into geologic formations representative of large storage capacity. Even though the RCSP Program is being implemented in three phases, it should be viewed as an integrated whole, with many of the goals and objectives transitioning from one phase to the next. Accomplishments and results from the Characterization Phase have helped to refine goals and activities in the Validation and Deployment Phases. The RCSP Program encourages and requires open information sharing among

  10. Cancer Prevention Interdisciplinary Education Program at Purdue University: Overview and Preliminary Results

    Science.gov (United States)

    Teegarden, Dorothy; Lee, Ji-Yeon; Adedokun, Omolola; Childress, Amy; Parker, Loran Carleton; Burgess, Wilella; Nagel, Julie; Knapp, Deborah W.; Lelievre, Sophie; Agnew, Christopher R.; Shields, Cleveland; Leary, James; Adams, Robin; Jensen, Jakob D.

    2012-01-01

    Cancer prevention is a broad field that crosses many disciplines; therefore, educational efforts to enhance cancer prevention research focused on interdisciplinary approaches to the field are greatly needed. In order to hasten progress in cancer prevention research, the Cancer Prevention Internship Program (CPIP) at Purdue University was designed to develop and test an interdisciplinary curriculum for undergraduate and graduate students. The hypothesis was that course curriculum specific to introducing interdisciplinary concepts in cancer prevention would increase student interest in and ability to pursue advanced educational opportunities (e.g., graduate school, medical school). Preliminary results from the evaluation of the first year which included 10 undergraduate and 5 graduate students suggested that participation in CPIP is a positive professional development experience, leading to a significant increase in understanding of interdisciplinary research in cancer prevention. In its first year, the CPIP project has created a successful model for interdisciplinary education in cancer prevention research. PMID:21533583

  11. Geriatric Nursing Master’s Degree Program Overviews in Iran: Review Article

    Directory of Open Access Journals (Sweden)

    Leila Valizadeh

    2016-03-01

    Full Text Available ​The increasing number of elderly in recent years has led to great changes in the country's healthcare system. One of these changes is developing geriatric nursing master degree. This paper, with non-systematic approach, presents an evaluation of geriatric nursing graduate program in Iran. According to the results, mission and curriculum of the course are written in details. The number of faculties and students is rising every year. It seems that “the teacher shortage” and “determining the accurate and appropriate job status” for graduates are the main challenges. Given the young nature of the field, it is strongly recommended to reassess after some years.

  12. THE DOE OFFICE OF ENVIRONMENTAL MANAGEMENT INTERNATIONAL COOPERATIVE PROGRAM: OVERVIEW OF TECHNICAL TASKS AND RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Marra, J.; Fox, K.; Farfan, E.; Jannik, T.

    2009-12-08

    The DOE Office of Environmental Management (DOE-EM) Office of Engineering and Technology is responsible for implementing EM's International Cooperative Program. Over the past 15 years, collaborative work has been conducted through this program with researchers in Russia, Ukraine, France, United Kingdom and Republic of Korea. Currently, work is being conducted with researchers in Russia and Ukraine. Efforts aimed at evaluating and advancing technologies to support U.S. high-level waste (HLW) vitrification initiatives are being conducted in collaboration with Russian researchers. Work at Khlopin Radium Institute (KRI) is targeted at improving the throughput of current vitrification processes by increasing melting rate. These efforts are specifically targeted at challenging waste types identified at the Savannah River Site (SRS) and Hanford Site. The objectives of current efforts at SIA Radon are to gain insight into vitrification process limits for the cold crucible induction melter (CCIM) technology. Previous demonstration testing has shown that the CCIM offers the potential for dramatic increases in waste loading and waste throughput. However, little information is known regarding operational limits that could affect long-term, efficient CCIM operations. Collaborative work with the Russian Electrotechnical University (ETU) 'LETI' is aimed at advancing CCIM process monitoring, process control and design. The goal is to further mature the CCIM technology and to establish it as a viable HLW vitrification technology. The greater than two year effort conducted with the International Radioecology Laboratory in the Ukraine recently completed. The objectives of this study were: to assess the long-term impacts to the environment from radiation exposure in the Chernobyl Exclusion Zone (ChEZ); and to provide information on remediation guidelines and ecological risk assessment within radioactively contaminated territories around the Chernobyl Nuclear Power Plant

  13. The DOE Office of Environmental Management International Cooperative Program: Overview of Technical Tasks and Results

    Energy Technology Data Exchange (ETDEWEB)

    Marra, James C.; Fox, Kevin M.; Jannik, Gerald T.; Farfan, Eduardo B.; Kim, Dong-Sang; Vienna, John D.; Roach, Jay; Aloy, A. S.; Stefanovsky, S. V.; Lopukh, D. B.; Bondarkov, M. D.; Gerdes, Kurt D.; Han, Ana M.

    2010-01-22

    The DOE Office of Environmental Management (DOE-EM) Office of Engineering and Technology is responsible for implementing EM’s International Cooperative Program. Over the past 15 years, collaborative work has been conducted through this program with researchers in Russia, Ukraine, France, United Kingdom and Republic of Korea. Currently, work is being conducted with researchers in Russia and Ukraine. Efforts aimed at evaluating and advancing technologies to support U.S. high-level waste (HLW) vitrification initiatives are being conducted in collaboration with Russian researchers. Work at Khlopin Radium Institute (KRI) is targeted at improving the throughput of current vitrification processes by increasing melting rate. These efforts are specifically targeted at challenging waste types identified at the Savannah River Site (SRS) and Hanford Site. The objectives of current efforts at SIA Radon are to gain insight into vitrification process limits for the cold crucible induction melter (CCIM) technology. Previous demonstration testing has shown that the CCIM offers the potential for dramatic increases in waste loading and waste throughput. However, little information is known regarding operational limits that could affect long-term, efficient CCIM operations. Collaborative work with the Russian Electrotechnical University (ETU) “LETI” is aimed at advancing CCIM process monitoring, process control and design. The goal is to further mature the CCIM technology and to establish it as a viable HLW vitrification technology. The greater than two year effort conducted with the International Radioecology Laboratory in the Ukraine recently completed. The objectives of this study were: to assess the long-term impacts to the environment from radiation exposure in the Chernobyl Exclusion Zone (ChEZ); and to provide information on remediation guidelines and ecological risk assessment within radioactively contaminated territories around the Chernobyl Nuclear Power Plant (Ch

  14. THE DOE OFFICE OF ENVIRONMENTAL MANAGEMENT INTERNATIONAL COOPERATIVE PROGRAM: OVERVIEW OF TECHNICAL TASKS AND RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Marra, J.; Fox, K.; Farfan, E.; Jannik, T.

    2009-12-08

    The DOE Office of Environmental Management (DOE-EM) Office of Engineering and Technology is responsible for implementing EM's International Cooperative Program. Over the past 15 years, collaborative work has been conducted through this program with researchers in Russia, Ukraine, France, United Kingdom and Republic of Korea. Currently, work is being conducted with researchers in Russia and Ukraine. Efforts aimed at evaluating and advancing technologies to support U.S. high-level waste (HLW) vitrification initiatives are being conducted in collaboration with Russian researchers. Work at Khlopin Radium Institute (KRI) is targeted at improving the throughput of current vitrification processes by increasing melting rate. These efforts are specifically targeted at challenging waste types identified at the Savannah River Site (SRS) and Hanford Site. The objectives of current efforts at SIA Radon are to gain insight into vitrification process limits for the cold crucible induction melter (CCIM) technology. Previous demonstration testing has shown that the CCIM offers the potential for dramatic increases in waste loading and waste throughput. However, little information is known regarding operational limits that could affect long-term, efficient CCIM operations. Collaborative work with the Russian Electrotechnical University (ETU) 'LETI' is aimed at advancing CCIM process monitoring, process control and design. The goal is to further mature the CCIM technology and to establish it as a viable HLW vitrification technology. The greater than two year effort conducted with the International Radioecology Laboratory in the Ukraine recently completed. The objectives of this study were: to assess the long-term impacts to the environment from radiation exposure in the Chernobyl Exclusion Zone (ChEZ); and to provide information on remediation guidelines and ecological risk assessment within radioactively contaminated territories around the Chernobyl Nuclear Power Plant

  15. K9BB METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  16. K9MN METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  17. Mount Elbert Gas Hydrate Stratigraphic Test Well, Alaska North Slope: Overview of scientific and technical program

    Science.gov (United States)

    Hunter, R.B.; Collett, T.S.; Boswell, R.; Anderson, B.J.; Digert, S.A.; Pospisil, G.; Baker, R.; Weeks, M.

    2011-01-01

    scientific research programs can be safely, effectively, and efficiently conducted within ANS infrastructure. The program success resulted in a technical team recommendation to project management to drill and complete a long-term production test within the area of existing ANS infrastructure. If approved by stakeholders, this long-term test would build on prior arctic research efforts to better constrain the potential gas rates and volumes that could be produced from gas hydrate-bearing sand reservoirs. ?? 2010 Elsevier Ltd.

  18. Overview of the TCV tokamak program: scientific progress and facility upgrades

    Science.gov (United States)

    Coda, S.; Ahn, J.; Albanese, R.; Alberti, S.; Alessi, E.; Allan, S.; Anand, H.; Anastassiou, G.; Andrèbe, Y.; Angioni, C.; Ariola, M.; Bernert, M.; Beurskens, M.; Bin, W.; Blanchard, P.; Blanken, T. C.; Boedo, J. A.; Bolzonella, T.; Bouquey, F.; Braunmüller, F. H.; Bufferand, H.; Buratti, P.; Calabró, G.; Camenen, Y.; Carnevale, D.; Carpanese, F.; Causa, F.; Cesario, R.; Chapman, I. T.; Chellai, O.; Choi, D.; Cianfarani, C.; Ciraolo, G.; Citrin, J.; Costea, S.; Crisanti, F.; Cruz, N.; Czarnecka, A.; Decker, J.; De Masi, G.; De Tommasi, G.; Douai, D.; Dunne, M.; Duval, B. P.; Eich, T.; Elmore, S.; Esposito, B.; Faitsch, M.; Fasoli, A.; Fedorczak, N.; Felici, F.; Février, O.; Ficker, O.; Fietz, S.; Fontana, M.; Frassinetti, L.; Furno, I.; Galeani, S.; Gallo, A.; Galperti, C.; Garavaglia, S.; Garrido, I.; Geiger, B.; Giovannozzi, E.; Gobbin, M.; Goodman, T. P.; Gorini, G.; Gospodarczyk, M.; Granucci, G.; Graves, J. P.; Guirlet, R.; Hakola, A.; Ham, C.; Harrison, J.; Hawke, J.; Hennequin, P.; Hnat, B.; Hogeweij, D.; Hogge, J.-Ph.; Honoré, C.; Hopf, C.; Horáček, J.; Huang, Z.; Igochine, V.; Innocente, P.; Ionita Schrittwieser, C.; Isliker, H.; Jacquier, R.; Jardin, A.; Kamleitner, J.; Karpushov, A.; Keeling, D. L.; Kirneva, N.; Kong, M.; Koubiti, M.; Kovacic, J.; Krämer-Flecken, A.; Krawczyk, N.; Kudlacek, O.; Labit, B.; Lazzaro, E.; Le, H. B.; Lipschultz, B.; Llobet, X.; Lomanowski, B.; Loschiavo, V. P.; Lunt, T.; Maget, P.; Maljaars, E.; Malygin, A.; Maraschek, M.; Marini, C.; Martin, P.; Martin, Y.; Mastrostefano, S.; Maurizio, R.; Mavridis, M.; Mazon, D.; McAdams, R.; McDermott, R.; Merle, A.; Meyer, H.; Militello, F.; Miron, I. G.; Molina Cabrera, P. A.; Moret, J.-M.; Moro, A.; Moulton, D.; Naulin, V.; Nespoli, F.; Nielsen, A. H.; Nocente, M.; Nouailletas, R.; Nowak, S.; Odstrčil, T.; Papp, G.; Papřok, R.; Pau, A.; Pautasso, G.; Pericoli Ridolfini, V.; Piovesan, P.; Piron, C.; Pisokas, T.; Porte, L.; Preynas, M.; Ramogida, G.; Rapson, C.; Rasmussen, J. Juul; Reich, M.; Reimerdes, H.; Reux, C.; Ricci, P.; Rittich, D.; Riva, F.; Robinson, T.; Saarelma, S.; Saint-Laurent, F.; Sauter, O.; Scannell, R.; Schlatter, Ch.; Schneider, B.; Schneider, P.; Schrittwieser, R.; Sciortino, F.; Sertoli, M.; Sheikh, U.; Sieglin, B.; Silva, M.; Sinha, J.; Sozzi, C.; Spolaore, M.; Stange, T.; Stoltzfus-Dueck, T.; Tamain, P.; Teplukhina, A.; Testa, D.; Theiler, C.; Thornton, A.; Tophøj, L.; Tran, M. Q.; Tsironis, C.; Tsui, C.; Uccello, A.; Vartanian, S.; Verdoolaege, G.; Verhaegh, K.; Vermare, L.; Vianello, N.; Vijvers, W. A. J.; Vlahos, L.; Vu, N. M. T.; Walkden, N.; Wauters, T.; Weisen, H.; Wischmeier, M.; Zestanakis, P.; Zuin, M.; the EUROfusion MST1 Team

    2017-10-01

    The TCV tokamak is augmenting its unique historical capabilities (strong shaping, strong electron heating) with ion heating, additional electron heating compatible with high densities, and variable divertor geometry, in a multifaceted upgrade program designed to broaden its operational range without sacrificing its fundamental flexibility. The TCV program is rooted in a three-pronged approach aimed at ITER support, explorations towards DEMO, and fundamental research. A 1 MW, tangential neutral beam injector (NBI) was recently installed and promptly extended the TCV parameter range, with record ion temperatures and toroidal rotation velocities and measurable neutral-beam current drive. ITER-relevant scenario development has received particular attention, with strategies aimed at maximizing performance through optimized discharge trajectories to avoid MHD instabilities, such as peeling-ballooning and neoclassical tearing modes. Experiments on exhaust physics have focused particularly on detachment, a necessary step to a DEMO reactor, in a comprehensive set of conventional and advanced divertor concepts. The specific theoretical prediction of an enhanced radiation region between the two X-points in the low-field-side snowflake-minus configuration was experimentally confirmed. Fundamental investigations of the power decay length in the scrape-off layer (SOL) are progressing rapidly, again in widely varying configurations and in both D and He plasmas; in particular, the double decay length in L-mode limited plasmas was found to be replaced by a single length at high SOL resistivity. Experiments on disruption mitigation by massive gas injection and electron-cyclotron resonance heating (ECRH) have begun in earnest, in parallel with studies of runaway electron generation and control, in both stable and disruptive conditions; a quiescent runaway beam carrying the entire electrical current appears to develop in some cases. Developments in plasma control have benefited from

  19. Overview of high-Q2 nucleon form factor program with Super BigBite Spectrometer in JLab's Hall A

    Science.gov (United States)

    Puckett, Andrew; Jefferson Lab Hall A; Super BigBite Spectrometer Collaboration

    2017-01-01

    The elastic electromagnetic form factors (EMFFs) of the nucleon describe the impact-parameter-space distributions of electric charge and magnetization in the nucleon in the infinite momentum frame. The form factors are among the simplest and most fundamental measurable dynamical quantities describing the nucleon's structure. Precision measurements of the nucleon form factors provide stringent benchmarks testing the most sophisticated theoretical models of the nucleon, as well as ab initio calculations in lattice QCD and continuum non-perturbative QCD calculations based on the Dyson-Schwinger equations. Measurements at momentum transfers Q in the few-GeV range probe the theoretically challenging region of transition between the non-perturbative and perturbative regimes of QCD. The recent upgrade of the Continuous Electron Beam Accelerator Facility (CEBAF) to a maximum electron beam energy of 11 GeV will facilitate the measurement of the nucleon helicity-conserving (F1) and helicity-flip (F2) form factors of both proton and neutron to Q2 > 10 GeV2, In this talk, I will present an overview of the Super BigBite Spectrometer, currently under construction in CEBAF's experimental Hall A, and its physics program of high-Q2 nucleon EMFF measurements. Supported by US DOE award DE-SC0014230.

  20. H0LiCOW I. H0 Lenses in COSMOGRAIL's Wellspring: Program Overview

    CERN Document Server

    Suyu, S H; Courbin, F; Fassnacht, C D; Rusu, C E; Sluse, D; Treu, T; Wong, K C; Auger, M W; Ding, X; Hilbert, S; Marshall, P J; Rumbaugh, N; Sonnenfeld, A; Tewes, M; Tihhonova, O; Agnello, A; Blandford, R D; Chen, G C -F; Collett, T; Koopmans, L V E; Liao, K; Meylan, G; Spiniello, C

    2016-01-01

    Strong gravitational lens systems with time delays between the multiple images are a powerful probe of cosmology and astrophysics. In particular, the time-delay distance from such a system is primarily sensitive to the Hubble constant that is key to probing dark energy, neutrino physics, and the spatial curvature of the Universe, as well as discovering new physics. We present H0LiCOW (H0 Lenses in COSMOGRAIL's Wellspring), a program that aims to measure H0 with <3.5% uncertainty in precision and accuracy from five lens systems (B1608+656, RXJ1131-1231, HE0435-1223, WFI2033-4723 and HE1104-1805). We have acquired or are in the process of acquiring (1) time delays through COSMOGRAIL and Very Large Array monitoring, (2) high-resolution Hubble Space Telescope imaging for the lens mass modeling, (3) wide-field imaging and spectroscopy to characterize the lens environment, and (4) moderate-resolution spectroscopy for obtaining the stellar velocity dispersion of the lenses and, thus, to further constrain our lens...

  1. Integrated design and synthesis of smart material systems: an overview of the ARPA SPICES program

    Science.gov (United States)

    Jacobs, Jack H.

    1995-05-01

    The Synthesis and Processing of Intelligent Cost Effective Structures (SPICES) program is comprised of a consortium of industrial, academic and government labs to develop cost effective material processing and synthesis technologies to enable new products using active vibration suppression and control devices to be brought to market. Each team member possesses a specialty in the area of smart structures which has been focused towards the development of several actively controlled smart material systems. Since smart structures involve the integration of multiple engineering disciplines, it is the objective of the consortium to establish cost effective design processes between this multiorganizational team for future incorporation of this new technology into each members respective product lines. To accomplish this task, the disciplines of materials, manufacturing, analytical modeling, actuation, sensing, signal processing, and control had to be synthesized into a unified approach between all ten consortium members. The process developed for intelligent structural systems can truly be classified as multiorganization/multidiciplined Integrated Product Development. This process is described in detail as it applies to the SPICES development articles and smart material fabrication in general.

  2. Overview of C-2U FRC Experimental Program and Plans for C-2W

    Science.gov (United States)

    Gota, H.; Binderbauer, M. W.; Tajima, T.; Putvinski, S.; Tuszewski, M.; Dettrick, S.; Korepanov, S.; Smirnov, A.; Thompson, M. C.; Yang, X.; Cappello, M.; Ivanov, A. A.; TAE Team

    2016-10-01

    Tri Alpha Energy's experimental program has been focused on a demonstration of reliable field-reversed configuration (FRC) formation and sustainment, driven by fast ions via high-power neutral-beam (NB) injection. The world's largest compact-toroid experimental devices, C-2 and C-2U, have successfully produced a well-stabilized, sustainable FRC plasma state with NB injection (input power, PNB 10 + MW; 15 keV hydrogen) and end-on coaxial plasma guns. Remarkable improvements in confinement and stability of FRC plasmas have led to further improved fast-ion build up; thereby, an advanced beam-driven FRC state has been produced and sustained for up to 5 + ms (longer than all characteristic system time scales), only limited by hardware and electric supply constraints such as NB and plasma-gun power supplies. To further improve the FRC performance the C-2U device is being replaced by C-2W featuring higher injected NB power, longer pulse duration as well as enhanced edge-biasing systems and substantially upgraded divertors. Main C-2U experimental results and key features of C-2W will be presented. Tri Alpha Energy, Inc.

  3. An overview of the HSST Full-Thickness Shallow-Crack Clad Beam Testing Program

    Science.gov (United States)

    Keeney, J. A.; Theiss, T. J.; McAfee, W. J.; Bass, B. R.

    1994-08-01

    A testing program is described that will utilize full-thickness clad beam specimens to quantify fracture toughness for shallow flaws in material for which metallurgical conditions are prototypic of those found in reactor pressure vessels (RPV's). The beam specimens are fabricated from a section of an RPV wall that includes weld, plate and clad material. Metallurgical factors potentially influencing fracture toughness for shallow flaws in the beam specimen include material gradients due to welding and cladding applications, as well as material inhomogeneities in welded regions due to reheating in multiple weld passes. Fracture toughness tests focusing on shallow flaws in plate and weld material will also provide data for evaluating the relative influence of absolute and normalized crack depth on constraint conditions. Pretest finite-element analyses are described that provide near-tip stress and strain fields for characterization of constraint in the shallow-crack specimens in terms of the Q-stress. Analysis results predict a constraint loss in the shallow-crack clad beam specimen similar to that determined for a previously tested shallow-crack single-edge notch homogeneous bend specimen with the same normalized crack depth.

  4. Overview of the U.S. Department of Energy Formerly Utilized Sites Remedial Action Program - 12189

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Christopher [U.S. Department of Energy Office of Legacy Management, Washington, DC; Kothari, Vijendra [U.S. Department of Energy Office of Legacy Management, Morgantown, West Virginia; Starr, Ken [U.S. Department of Energy Office of Legacy Management, Westminster, Colorado; Gillespie, Joey [S.M. Stoller Corporation, Contractor for the U.S. Department of Energy Office of Legacy Management, Grand Junction, Colorado; Widdop, Michael [S.M. Stoller Corporation, Contractor for the U.S. Department of Energy Office of Legacy Management, Grand Junction, Colorado; none,

    2012-02-26

    The U.S. Department of Energy (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to address residual radiological contamination at sites where work was performed for the Manhattan Engineer District and U.S. Atomic Energy Commission. Initially, FUSRAP activities began with a records search for sites that had the potential to contain residual radiological contamination; 46 sites were identified that were eligible for and required remediation. Remedial action began in 1979. In 1997, Congress assigned responsibility for the remediation of FUSRAP sites to the U.S. Army Corps of Engineers (USACE). DOE retains responsibility for determining if sites are eligible for FUSRAP remediation and for providing long-term surveillance and maintenance (LTS&M) of remediated FUSRAP sites. DOE LTS&M activities are designed to ensure that FUSRAP sites remain protective of human health and the environment and to preserve knowledge regarding FUSRAP sites. Additional elements include eligibility determinations, transition of remediated sites from USACE to DOE, LTS&M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close coordination with USACE and regulators to ensure there is no loss of protectiveness when sites transition to DOE for LTS&M.

  5. Commercial Building Energy Asset Score System: Program Overview and Technical Protocol (Version 1.0)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Gorrissen, Willy J.

    2013-01-11

    The U.S. Department of Energy (DOE) is developing a national voluntary energy asset score system that includes an energy asset score tool to help building owners evaluate their buildings with respect to the score system. The goal of the energy asset score system is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system will allow building owners and managers to compare their building infrastructure against peers and track building upgrade progress over time. The system can also help other building stakeholders (e.g., building operators, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from their operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset score tool. This report also describes alternative methods that were considered prior to developing the current approach. Finally, this report describes a few features of the program where alternative approaches are still under evaluation.

  6. Overview of the RFX-mod contribution to the international Fusion Science Program

    Science.gov (United States)

    Puiatti, M. E.; Dal Bello, S.; Marrelli, L.; Martin, P.; Agostinetti, P.; Agostini, M.; Antoni, V.; Auriemma, F.; Barbisan, M.; Barbui, T.; Baruzzo, M.; Battistella, M.; Belli, F.; Bettini, P.; Bigi, M.; Bilel, R.; Boldrin, M.; Bolzonella, T.; Bonfiglio, D.; Brombin, M.; Buffa, A.; Canton, A.; Cappello, S.; Carraro, L.; Cavazzana, R.; Cester, D.; Chacon, L.; Chapman, B. E.; Chitarin, G.; Ciaccio, G.; Cooper, W. A.; Dalla Palma, M.; Deambrosis, S.; Delogu, R.; De Lorenzi, A.; De Masi, G.; Dong, J. Q.; Escande, D. F.; Esposito, B.; Fassina, A.; Fellin, F.; Ferro, A.; Finotti, C.; Franz, P.; Frassinetti, L.; Furno Palumbo, M.; Gaio, E.; Ghezzi, F.; Giudicotti, L.; Gnesotto, F.; Gobbin, M.; Gonzales, W. A.; Grando, L.; Guo, S. C.; Hanson, J. D.; Hirshman, S. P.; Innocente, P.; Jackson, J. L.; Kiyama, S.; Komm, M.; Laguardia, L.; Li, C.; Liu, S. F.; Liu, Y. Q.; Lorenzini, R.; Luce, T. C.; Luchetta, A.; Maistrello, A.; Manduchi, G.; Mansfield, D. K.; Marchiori, G.; Marconato, N.; Marocco, D.; Marcuzzi, D.; Martines, E.; Martini, S.; Matsunaga, G.; Mazzitelli, G.; Miorin, E.; Momo, B.; Moresco, M.; Okabayashi, M.; Olofsson, E.; Paccagnella, R.; Patel, N.; Pavei, M.; Peruzzo, S.; Pilan, N.; Pigatto, L.; Piovan, R.; Piovesan, P.; Piron, C.; Piron, L.; Predebon, I.; Rea, C.; Recchia, M.; Rigato, V.; Rizzolo, A.; Roquemore, A. L.; Rostagni, G.; Ruset, C.; Ruzzon, A.; Sajò-Bohus, L.; Sakakita, H.; Sanchez, R.; Sarff, J. S.; Sartori, E.; Sattin, F.; Scaggion, A.; Scarin, P.; Schmitz, O.; Sonato, P.; Spada, E.; Spagnolo, S.; Spolaore, M.; Spong, D. A.; Spizzo, G.; Stevanato, L.; Takechi, M.; Taliercio, C.; Terranova, D.; Trevisan, G. L.; Urso, G.; Valente, M.; Valisa, M.; Veranda, M.; Vianello, N.; Viesti, G.; Villone, F.; Vincenzi, P.; Visona', N.; Wang, Z. R.; White, R. B.; Xanthopoulos, P.; Xu, X. Y.; Yanovskiy, V.; Zamengo, A.; Zanca, P.; Zaniol, B.; Zanotto, L.; Zilli, E.; Zuin, M.

    2015-10-01

    The RFX-mod device is operated both as a reversed field pinch (RFP), where advanced regimes featuring helical shape develop, and as a tokamak. Due to its flexibility, RFX-mod is contributing to the solution of key issues in the roadmap to ITER and DEMO, including MHD instability control, internal transport barriers, edge transport and turbulence, isotopic effect, high density limit and three-dimensional (3D) non-linear MHD modelling. This paper reports recent advancements in the understanding of the self-organized helical states, featuring a strong electron transport barrier, in the RFP configuration; the physical mechanism driving the residual transport at the barrier has been investigated. Following the first experiments with deuterium as the filling gas, new results concerning the isotope effect in the RFP are discussed. Studies on the high density limit show that in the RFP it is related to a toroidal particle accumulation due to the onset of a convective cell. In the tokamak configuration, q(a) regimes down to q(a) = 1.2 have been pioneered, with (2,1) tearing mode (TM) mitigated and (2,1) resistive wall mode (RWM) stabilized: the control of such modes can be obtained both by poloidal and radial sensors. Progress has been made in the avoidance of disruptions due to the (2,1) TM by applying q(a) control, and on the general issue of error field control. The effect of externally applied 3D fields on plasma flow and edge turbulence, sawtooth control and runaway electron decorrelation has been analysed. The experimental program is supported by substantial theoretical activity: 3D non-linear visco-resistive MHD and non-local transport modelling have been advanced; RWMs have been studied by a toroidal MHD kinetic hybrid stability code.

  7. An overview of the United States Department of Energy plant lifetime improvement program

    Energy Technology Data Exchange (ETDEWEB)

    Rosinski, S.T.; Clauss, J.M. [Sandia National Labs., Albuquerque, NM (United States); Harrison, D.L. [USDOE, Washington, DC (United States)

    1993-08-01

    Today, 109 nuclear power plants provide over 20 percent of the electrical energy generated in the US. The operating license of the first of these plants will expire in the year 2000; one third of the operating licenses will expire by 2010 and the remaining plant licenses are scheduled to expire by 2033. The National Energy Strategy assumes that 70 percent of these plants will continue to operate beyond their current license expiration to assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth. In order to preserve this energy resource in the US three major tasks must be successfully completed: (1) establishment of the regulations, technical standards, and procedures for the preparation and review of a license renewal application; (2) development, verification, and validation of the various technical criteria and bases for needed monitoring, refurbishment, or replacement of plant equipment; and (3) demonstration of the regulatory process. Since 1985, the US Department of Energy (DOE) has been working with the nuclear industry and the US Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of nuclear power plants through the renewal of operating licenses. This paper focuses primarily on DOE`s Plant Lifetime Improvement (PLIM) Program efforts to develop the technical criteria and bases for effective aging management and lifetime improvement for continued operation of nuclear power plants. This paper describes current projects to resolve generic technical issues, including degradation of long-lived components, reactor pressure vessel (RPV) embrittlement management approaches, and analytical methodologies to characterize RPV integrity.

  8. ARPA/NIJ/Rome Laboratory concealed weapon detection program: an overview

    Science.gov (United States)

    Currie, Nicholas C.; Demma, Fred J.; Ferris, David D., Jr.; McMillan, Robert W.; Wicks, Michael C.

    1996-06-01

    Recent advances in passive and active imaging and non- imaging sensor technology offer the potential to detect weapons that are concealed beneath a person's clothing. Sensors that are discussed in this paper are characterized as either non-imaging or imaging. Non-imaging sensors include wide band radar and portal devices such as metal detectors. In general the strength of non-imaging sensors rest with the fact that they are generally inexpensive and can rapidly perform bulk separation between regions where persons are likely to be carrying concealed weapons and those regions that are likely to contain persons who are unarmed. The bulk process is typically accomplished at the expense of false alarm rate. Millimeter-wave (MMW), microwave, x-ray, acoustic, magnetic, and infrared (IR) imaging sensor technologies provide with greater certainty the means to isolate persons within a crowd that are carrying concealed weapons and to identify the weapon type. The increased certainty associated with imaging sensors is accomplished at the expense of cost and bulk surveillance of the crowd. CWD technologies have a variety of military and civilian applications. This technology focus area addresses specific military needs under the Defense Advanced Research Projects Agency's (DARPA) operations other than war/law enforcement (OOTW/LE). Additionally, this technology has numerous civilian law enforcement applications that are being investigated under the National Institute of Justice's (NIJ) Concealed Weapons Detection program. This paper discusses the wide variety of sensors that might be employed in support of a typical scenario, the strengths and weaknesses of each of the sensors relative to the given scenario, and how CWD breadboards will be tested to determine the optimal CWD application. It rapidly becomes apparent that no single sensor will completely satisfy the CWD mission necessitating the fusion of two or more of these sensors.

  9. Overview of the DoD's rf multifunction structural aperture (MUSTRAP) program

    Science.gov (United States)

    Alt, Kevin H.; Lockyer, Allen J.; Coughlin, Daniel P.; Kudva, Jayanth N.; Tuss, James

    2001-08-01

    structural and electrical performance. Highlights of the program are presented in the text.

  10. Next Generation Safeguards Initiative: Overview and Policy Context of UF6 Cylinder Tracking Program

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, Brian D [Los Alamos National Laboratory; Whitaker, J. Michael [ORNL; White-Horton, Jessica L. [ORNL; Durbin, Karyn R. [NNSA

    2012-07-12

    Thousands of cylinders containing uranium hexafluoride (UF{sub 6}) move around the world from conversion plants to enrichment plants to fuel fabrication plants, and their contents could be very useful to a country intent on diverting uranium for clandestine use. Each of these large cylinders can contain close to a significant quantity of natural uranium (48Y cylinder) or low-enriched uranium (LEU) (30B cylinder) defined as 75 kg {sup 235}U which can be further clandestinely enriched to produce 1.5 to 2 significant quantities of high enriched uranium (HEU) within weeks or months depending on the scale of the clandestine facility. The National Nuclear Security Administration (NNSA) Next Generation Safeguards Initiative (NGSI) kicked off a 5-year plan in April 2011 to investigate the concept of a unique identification system for UF{sub 6} cylinders and potentially to develop a cylinder tracking system that could be used by facility operators and the International Atomic Energy Agency (IAEA). The goal is to design an integrated solution beneficial to both industry and inspectorates that would improve cylinder operations at the facilities and provide enhanced capabilities to deter and detect both diversion of low-enriched uranium and undeclared enriched uranium production. The 5-year plan consists of six separate incremental tasks: (1) define the problem and establish the requirements for a unique identification (UID) and monitoring system; (2) develop a concept of operations for the identification and monitoring system; (3) determine cylinder monitoring devices and technology; (4) develop a registry database to support proof-of-concept demonstration; (5) integrate that system for the demonstration; and (6) demonstrate proof-of-concept. Throughout NNSA's performance of the tasks outlined in this program, the multi-laboratory team emphasizes that extensive engagement with industry stakeholders, regulatory authorities and inspectorates is essential to its success.

  11. The NASA/Industry Design Analysis Methods for Vibrations (DAMVIBS) Program - A government overview. [of rotorcraft technology development using finite element method

    Science.gov (United States)

    Kvaternik, Raymond G.

    1992-01-01

    An overview is presented of government contributions to the program called Design Analysis Methods for Vibrations (DAMV) which attempted to develop finite-element-based analyses of rotorcraft vibrations. NASA initiated the program with a finite-element modeling program for the CH-47D tandem-rotor helicopter. The DAMV program emphasized four areas including: airframe finite-element modeling, difficult components studies, coupled rotor-airframe vibrations, and airframe structural optimization. Key accomplishments of the program include industrywide standards for modeling metal and composite airframes, improved industrial designs for vibrations, and the identification of critical structural contributors to airframe vibratory responses. The program also demonstrated the value of incorporating secondary modeling details to improving correlation, and the findings provide the basis for an improved finite-element-based dynamics design-analysis capability.

  12. A role for repressive complexes and H3K9 di-methylation in PRDM5-associated brittle cornea syndrome

    DEFF Research Database (Denmark)

    Porter, Louise F; Galli, Giorgio G; Williamson, Sally

    2015-01-01

    skin fibroblast expression microarrays from patients with PRDM5 mutations p.Arg590* and Δ exons 9-14, as well as from a PRDM5 ChIP-sequencing experiment. Gene ontology analysis of dysregulated PRDM5 target genes reveals enrichment for extracellular matrix (ECM) genes supporting vascular integrity...... and development. Q-PCR, and ChIP-qPCR confirm upregulation of critical mediators of ECM stability in vascular structures (COL13A1, COL15A1, NTN1, CDH5) in patient fibroblasts. We identify H3K9 di-methylation at these PRDM5 target genes in fibroblasts, and demonstrate that the BCS2 mutation p.Arg83Cys diminishes...

  13. H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases

    DEFF Research Database (Denmark)

    Hansen, Klavs R; Hazan, Idit; Shanker, Sreenath

    2011-01-01

    Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both multicellular eukaryotes and single-cell model...... organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic histone marks to the properties of heterochromatin remain largely undefined. Here, we report that silencing of the fission yeast mating-type cassettes, which are located in a well...... at multiple chromosomal locations in addition to affecting the mating-type region. The histone deacetylase Clr6 acts in the same pathway as Clr5, at least for its effects in the mating-type region, and on a subset of other targets, notably a region recently found to be prone to neo-centromere formation...

  14. Polarization-dependent characteristics of a racetrack waveguide resonator fabricated by ion exchange in K9 glass

    Institute of Scientific and Technical Information of China (English)

    Xiuyou Han; Feng Liu; Fufei Pang; Fenghong Chu; Haiwen Cai; Ronghui Qu; Zujie Fang

    2006-01-01

    @@ A racetrack waveguide resonator filter was fabricated by ion exchange technology in K9 optical glass.The filter responses of the waveguide resonator were measured with two polarized input lightwaves. The polarization-dependent characteristics of the waveguide resonator were analyzed, and the results of effective indices of Nte = 1.5721 and Ntm = 1.5548, coupling ratios of Rte = 0.731 and Rtm = 0.761, and losses of Αte = 4.35 Db/cm and Αtm = 6.05 Db/cm were obtained for transverse electric (TE) and transverse magnetic (TM) modes, respectively. The causes of large loss and effective index differences between TE and TM modes were discussed.

  15. Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

    Science.gov (United States)

    Ugarte, Fernando; Sousae, Rebekah; Cinquin, Bertrand; Martin, Eric W.; Krietsch, Jana; Sanchez, Gabriela; Inman, Margaux; Tsang, Herman; Warr, Matthew; Passegué, Emmanuelle; Larabell, Carolyn A.; Forsberg, E. Camilla

    2015-01-01

    Summary Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem cell function. Using nuclease sensitivity assays, we found a progressive decrease in chromatin digestion among pluripotent embryonic stem cells (ESCs), multipotent hematopoietic stem cells (HSCs), and mature hematopoietic cells. Quantitative high-resolution microscopy revealed that ESCs contain significantly more euchromatin than HSCs, with a further reduction in mature cells. Increased cellular maturation also led to heterochromatin localization to the nuclear periphery. Functionally, prevention of heterochromatin formation by inhibition of the histone methyltransferase G9A resulted in delayed HSC differentiation. Our results demonstrate global chromatin rearrangements during stem cell differentiation and that heterochromatin formation by H3K9 methylation regulates HSC differentiation. PMID:26489895

  16. DOG1 (clone K9) is seldom expressed and not useful in the evaluation of pancreatic neoplasms.

    Science.gov (United States)

    Hemminger, Jessica; Marsh, William L; Iwenofu, Obiajulu Hans; Frankel, Wendy L

    2012-07-01

    DOG1, a transmembrane calcium-regulated chloride channel protein, is a sensitive and specific marker for gastrointestinal stromal tumors compared with other spindle cell and epithelioid neoplasms. Overexpression has also been described in a variety of both benign and malignant epithelial neoplasms. Recently, DOG1 immunoreactivity has been reported in pancreatic solid pseudopapillary tumors (SPT), suggesting a role as a marker for SPT. Utilizing immunohistochemistry, we evaluated DOG1 expression in pancreatic neoplasms to determine the prevalence of staining and establish diagnostic utility. Multiple tissue microarrays (TMA) were created from cores of formalin-fixed paraffin-embedded blocks containing pancreatic adenocarcinomas (n=112), neuroendocrine tumors (n=99), serous cystadenomas (n=28), and SPT (n=14) as well as normal pancreas (n=12). Immunoreactivity for DOG1 (clone K9) was assessed for intensity (1 to 3+), percentage of tumor positivity and location. Of the 99 cases of neuroendocrine tumors, only 2 (2%) were focally positive. Patchy staining was identified in 8 cases (7%) of adenocarcinoma of 1 to 2+ intensity, involving 15% to 80% of the tumor cells and primarily seen in a membranous and luminal distribution. In contrast to a previous report, no DOG1 positivity was observed in SPT, evaluated by both TMA and full sections. The TMAs of serous cystadenomas and normal pancreas were negative for DOG1. Rarely, pancreatic islets displayed granular, cytoplasmic staining. DOG1 antibody clone K9 is not a useful marker for SPT or other primary pancreatic neoplasms. Additional studies may be helpful to evaluate differences between clones of DOG1.

  17. Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.

    Directory of Open Access Journals (Sweden)

    Michael Brauchle

    Full Text Available Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC domain-containing proteins are one class of broadly expressed enzymes catalyzing methyl group removal. However, several JmjC proteins remain uncharacterized, gaps persist in understanding substrate recognition, and the integration of JmjC proteins into signaling pathways is just emerging. The KDM3 subfamily is an evolutionarily conserved group of histone demethylase proteins, thought to share lysine substrate specificity. Here we use a systematic approach to compare KDM3 subfamily members. We show that full-length KDM3A and KDM3B are H3K9me1/2 histone demethylases whereas we fail to observe histone demethylase activity for JMJD1C using immunocytochemical and biochemical approaches. Structure-function analyses revealed the importance of a single amino acid in KDM3A implicated in the catalytic activity towards H3K9me1/2 that is not conserved in JMJD1C. Moreover, we use quantitative proteomic analyses to identify subsets of the interactomes of the 3 proteins. Specific interactor candidates were identified for each of the three KDM3 subfamily members. Importantly, we find that SCAI, a known transcriptional repressor, interacts specifically with KDM3B. Taken together, we identify substantial differences in the biology of KDM3 histone demethylases, namely enzymatic activity and protein-protein interactions. Such comparative approaches pave the way to a better understanding of histone demethylase specificity and protein function at a systems level and are instrumental in identifying the more subtle differences between closely related proteins.

  18. An overview of fiber-to-the-premises (FTTP) product requirements and qualification programs

    Science.gov (United States)

    Gebizlioglu, Osman S.; Gallo, Ernest J.

    2006-04-01

    North American deployments of FTTP architectures have been rapidly increasing. While the FTTP market is being driven by major telecommunications service providers, equipment suppliers have been scrambling to bring products to market that will ensure them a piece of this high-stakes market. In this invited presentation/paper, we propose to examine the technical requirements that are needed to support the new FTTP network with a host of new products that have been in development. To enable service providers select the best new products for FTTP deployment, product selection needs to be based on the analysis and testing of new products for performance and reliability, Telcordia, in its traditional role of telecommunications standards development, has been publishing generic requirements (GR) documents that have been used by suppliers, service providers and the industry at large. Product qualification programs based on the established performance and reliability requirements/standards have been designed to evaluate products to determine if they can 1) withstand the rigors of the outside plant deployment environment and perform for extended periods of time, 2) be upgradeable, and 3) craft friendly. The outside plant is a tough environment to live in. A product must perform under the extreme conditions of cold down -40°C (-40°F) and hot up to 46°C (115°F) with high humidity of 95%, rain, snow, sleet, vibration due to traffic, lightning, heating due to solar loads, high winds, ice, sand storms, and products are even tested to demonstrate if they can continue to operate in an earthquake, a wild fire and a shotgun blast. All FTTP products are not only expected to perform, but they must meet stringent optical performance criteria of low insertion loss and reflectance / return loss at a broad range of wavelengths from 1310, 1490, 1550 and 1625 nm. While the upstream (from the customer to the CO) voice and data transmission is currently planned over 1310-nm wavelength, the

  19. Earth2Class Overview: An Innovative Program Linking Classroom Educators and Research Scientists

    Science.gov (United States)

    Passow, M.; Iturrino, G. J.; Baggio, F. D.; Assumpcao, C. M.

    2005-12-01

    The Earth2Class (E2C) workshops, held at the Lamont-Doherty Earth Observatory (LDEO), provide an effective model for improving knowledge, teaching, and technology skills of middle and high school science educators through ongoing interactions with research scientists and educational technology. With support from an NSF GeoEd grant, E2C has developed monthly workshops, web-based resources, and summer institutes in which classroom teachers and research scientists have produced exemplar curriculum materials about a wide variety of cutting-edge geoscience investigations suitable for dissemination to teachers and students. Some of the goals of this program are focused to address questions such as: (1) What aspects of the E2C format and educational technology most effectively connect research discoveries with classroom teachers and their students? (2) What benefits result through interactions among teachers from highly diverse districts and backgrounds with research scientists, and what benefits do the scientists gain from participation? (3) How can the E2C format serve as a model for other research institution-school district partnerships as a mechanism for broader dissemination of scientific discoveries? E2C workshops have linked LDEO scientists from diverse research specialties-seismology, marine geology, paleoclimatology, ocean drilling, dendrochronology, remote sensing, impact craters, and others-with teachers from schools in the New York metropolitan area. Through the workshops, we have trained teachers to enhance content knowledge in the Earth Sciences and develop skills to incorporate new technologies. We have made a special effort to increase the teaching competency of K-12 Earth Sciences educators serving in schools with high numbers of students from underrepresented groups, thereby providing greater role models to attract students into science and math careers. E2C sponsored Earth Science Teachers Conferences, bringing together educators from New York and New

  20. ns脉冲激光作用下K9玻璃的等离子体谱图研究

    Institute of Scientific and Technical Information of China (English)

    刘丽炜; 蔡红星; 李昌立; 何双力; 张喜和; 冯锴

    2008-01-01

    建立一套激光等离子体光谱测量实验装置,以Nd:YAG调Q倍频固体激光器为激发光源,作用K9玻璃。通过对K9的等离子体谱图的分析发现,K9玻璃等离子体谱强度的变化与激光器输出能量呈线性关系。同时利用显微镜观察K9玻璃的表面损伤形貌,并进行理论分析。

  1. Effect of inclusion matrix model on temperature and thermal stress fields of K9-glass damaged by long-pulse laser

    Science.gov (United States)

    Pan, Yunxiang; Wang, Bin; Shen, Zhonghua; Lu, Jian; Ni, Xiaowu

    2013-04-01

    A model containing an inclusion matrix heated by a millisecond laser is proposed to calculate temperature and thermal stress fields of K9-glass using a finite element method. First, the evolution of temperature and thermal stress fields is analyzed. Results show that both the upper and lower surfaces are damaged. K9-glass is primarily damaged by the combination of radial and axial stresses. Calculated damage morphology is mainly determined by radial stress. Then damage morphology evolution with the increase of the incident laser energy is investigated, which shows that damage area spreads inward from both the front and rear surfaces. Finally, experimental results of long-pulse laser damage of K9-glass are analyzed. The comparison of numerical results with experimental observations shows a good correlation in damage morphology, which indicates that the built inclusion matrix model is applicable to long-pulse laser damage in K9-glass.

  2. Excel与MapGis K9相结合在山东县级林地保护利用规划中的应用

    Institute of Scientific and Technical Information of China (English)

    张晓红; 袁孟妍; 刘国群

    2016-01-01

    MapGis K9在山东省县级林地保护利用规划小班勾绘过程中操作简单,但在小班属性输入时却费时费力。本文通过excel与MapGis K9相结合,批量导入小班属性,大大提高了小班制图的效率。

  3. HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats.

    Directory of Open Access Journals (Sweden)

    Kerstin Mosch

    Full Text Available H3 lysine 9 trimethylation (H3K9me3 is a histone posttranslational modification (PTM that has emerged as hallmark of pericentromeric heterochromatin. This constitutive chromatin domain is composed of repetitive DNA elements, whose transcription is differentially regulated. Mammalian cells contain three HP1 proteins, HP1α, HP1β and HP1γ These have been shown to bind to H3K9me3 and are thought to mediate the effects of this histone PTM. However, the mechanisms of HP1 chromatin regulation and the exact functional role at pericentromeric heterochromatin are still unclear. Here, we identify activity-dependent neuroprotective protein (ADNP as an H3K9me3 associated factor. We show that ADNP does not bind H3K9me3 directly, but that interaction is mediated by all three HP1 isoforms in vitro. However, in cells ADNP localization to areas of pericentromeric heterochromatin is only dependent on HP1α and HP1β. Besides a PGVLL sequence patch we uncovered an ARKS motif within the ADNP homeodomain involved in HP1 dependent H3K9me3 association and localization to pericentromeric heterochromatin. While knockdown of ADNP had no effect on HP1 distribution and heterochromatic histone and DNA modifications, we found ADNP silencing major satellite repeats. Our results identify a novel factor in the translation of H3K9me3 at pericentromeric heterochromatin that regulates transcription.

  4. An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.

    Science.gov (United States)

    Sabbattini, Pierangela; Sjoberg, Marcela; Nikic, Svetlana; Frangini, Alberto; Holmqvist, Per-Henrik; Kunowska, Natalia; Carroll, Tom; Brookes, Emily; Arthur, Simon J; Pombo, Ana; Dillon, Niall

    2014-03-01

    Methylated histones H3K9 and H3K27 are canonical epigenetic silencing modifications in metazoan organisms, but the relationship between the two modifications has not been well characterized. H3K9me3 coexists with H3K27me3 in pluripotent and differentiated cells. However, we find that the functioning of H3K9me3 is altered by H3S10 phosphorylation in differentiated postmitotic osteoblasts and cycling B cells. Deposition of H3K9me3/S10ph at silent genes is partially mediated by the mitogen- and stress-activated kinases (MSK1/2) and the Aurora B kinase. Acquisition of H3K9me3/S10ph during differentiation correlates with loss of paused S5 phosphorylated RNA polymerase II, which is present on Polycomb-regulated genes in embryonic stem cells. Reduction of the levels of H3K9me3/S10ph by kinase inhibition results in increased binding of RNAPIIS5ph and the H3K27 methyltransferase Ezh1 at silent promoters. Our results provide evidence of a novel developmentally regulated methyl-phospho switch that modulates Polycomb regulation in differentiated cells and stabilizes repressed states.

  5. Overview of Relational Programming.

    Science.gov (United States)

    1981-11-01

    Computer Science Department Technical Report NPS52-81-014, Naval Postgraduate School, October 1981. [7) Whitehead, A. N. and Russell, B. Principia ... Mathematica to *56, Cambridge, 1970. 17 - APPENDIX: RELATIONAL CALCULUS - REVISED NOTATION - 18- Old Notation Name New Notation xGC class membership x EC

  6. The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation.

    Science.gov (United States)

    He, Quanyuan; Kim, Hyeung; Huang, Rui; Lu, Weisi; Tang, Mengfan; Shi, Fengtao; Yang, Dong; Zhang, Xiya; Huang, Junjiu; Liu, Dan; Songyang, Zhou

    2015-09-03

    In mammals, DNA methylation is essential for protecting repetitive sequences from aberrant transcription and recombination. In some developmental contexts (e.g., preimplantation embryos) DNA is hypomethylated but repetitive elements are not dysregulated, suggesting that alternative protection mechanisms exist. Here we explore the processes involved by investigating the role of the chromatin factors Daxx and Atrx. Using genome-wide binding and transcriptome analysis, we found that Daxx and Atrx have distinct chromatin-binding profiles and are co-enriched at tandem repetitive elements in wild-type mouse ESCs. Global DNA hypomethylation further promoted recruitment of the Daxx/Atrx complex to tandem repeat sequences, including retrotransposons and telomeres. Knockdown of Daxx/Atrx in cells with hypomethylated genomes exacerbated aberrant transcriptional de-repression of repeat elements and telomere dysfunction. Mechanistically, Daxx/Atrx-mediated repression seems to involve Suv39h recruitment and H3K9 trimethylation. Our data therefore suggest that Daxx and Atrx safeguard the genome by silencing repetitive elements when DNA methylation levels are low.

  7. Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.

    Science.gov (United States)

    Feng, Ya; Liu, Te; Dong, Su-Yan; Guo, Yan-Jie; Jankovic, Joseph; Xu, Huaxi; Wu, Yun-Cheng

    2015-08-01

    The protein deacetylase SIRT1 has been recognized to exert its protective effect by directly deacetylasing histone and many other transcriptional factors including p53. However, the effect of SIRT1 on p53 expression at the transcriptional level still remains to be elucidated. In this study, we found that rotenone treatment decreased cell viability, induced apoptosis, reduced SIRT1 level, and promoted p53 expression. Pre-treatment with resveratrol, a SIRT1 activator, could attenuate rotenone-induced cell injury and p53 expression, whereas down-regulation of SIRT1 directly increased p53 expression. Moreover, chromatin immunoprecipitation experiments showed that SIRT1 bound to H3K9 within the p53 promoter region, and this binding resulted in decreased H3K9 acetylation and increased H3K9 tri-methylation, thereby inhibiting p53 gene transcription. In conclusion, our data indicate that rotenone promotes p53 transcription and apoptosis through targeting SIRT1 and H3K9. This leads to nigrostriatal degeneration, the main pathogenic mechanism of motor features of Parkinson's disease. SIRT1, a deacetylase enzyme, has neuroprotective effects for Parkinson's disease via targeting various factors. Resveratrol activated SIRT1 can target H3K9 and regulate p53 gene expression at the transcriptional level, thus inhibiting p53 transcription to enhance neuroprotection, alleviating rotenone induced dopaminergic neurodegeneration. We think these findings should provide a new strategy for the treatment of Parkinson's disease.

  8. The histone H3K9 methylation and RNAi pathways regulate normalnucleolar and repeated DNA organization by inhibiting formation ofextrachromosomal DNAs

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Jamy C.; Karpen, Gary H.

    2006-06-15

    In order to identify regulators of nuclear organization, Drosophila mutants in the Su(var)3-9 histone H3K9 methyltransferase, RNAi pathway components, and other regulators of heterochromatin-mediated gene silencing were examined for altered nucleoli and positioning of repeated DNAs. Animals lacking components of the H3K9 methylation and RNAi pathways contained disorganized nucleoli, ribosomal DNA (rDNA) and satellite DNAs. The levels of H3K9 dimethylation (H3K9me2) in chromatin associated with repeated DNAs decreased dramatically in Su(var)3-9 and dcr-2 (dicer-2) mutant tissues compared to wild type. We also observed a substantial increase in extrachromosomal repeated DNAs in mutant tissues. The disorganized nucleolus phenotype depends on the presence of Ligase 4 (Lig4), and ecc DNA formation is not induced by removal of cohesin. We conclude that H3K9 methylation of rDNA and satellites, maintained by Su(var)3-9, HP1, and the RNAi pathway, is necessary for the structural stability of repeated DNAs, which is mediated through suppression of non-homologous end joining (NHEJ). These results suggest a mechanism for how local chromatin structure can regulate genome stability, and the organization of chromosomal elements and nuclear organelles.

  9. Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity

    Science.gov (United States)

    Ishimoto, Kenji; Kawamata, Natsuko; Uchihara, Yoshie; Okubo, Moeka; Fujimoto, Reiko; Gotoh, Eiko; Kakinouchi, Keisuke; Mizohata, Eiichi; Hino, Nobumasa; Okada, Yoshiaki; Mochizuki, Yasuhiro; Tanaka, Toshiya; Hamakubo, Takao; Sakai, Juro; Kodama, Tatsuhiko; Inoue, Tsuyoshi; Tachibana, Keisuke; Doi, Takefumi

    2016-01-01

    Posttranslational modifications (PTMs) of proteins play a crucial role in regulating protein-protein interactions, enzyme activity, subcellular localization, and stability of the protein. SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase that regulates the methylation of histone H3 on lysine 9 (H3K9), gene silencing, and transcriptional repression. The C-terminal region of SETDB1 is a key site for PTMs, and is essential for its enzyme activity in mammalian and insect cells. In this study, we aimed to evaluate more precisely the effect of PTMs on the H3K9 methyltransferase activity of SETDB1. Using mass spectrometry analysis, we show that the C-terminal region of human SETDB1 purified from insect cells is ubiquitinated. We also demonstrate that the ubiquitination of lysine 867 of the human SETDB1 is necessary for full H3K9 methyltransferase activity in mammalian cells. Finally, we show that SETDB1 ubiquitination regulates the expression of its target gene, serpin peptidase inhibitor, clade E, member 1 (SERPINE1) by methylating H3K9. These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity. PMID:27798683

  10. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.

    Science.gov (United States)

    Tachibana, Makoto; Ueda, Jun; Fukuda, Mikiko; Takeda, Naoki; Ohta, Tsutomu; Iwanari, Hiroko; Sakihama, Toshiko; Kodama, Tatsuhiko; Hamakubo, Takao; Shinkai, Yoichi

    2005-04-01

    Histone H3 Lys 9 (H3-K9) methylation is a crucial epigenetic mark for transcriptional silencing. G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regions and is essential for murine embryogenesis. There is a single G9a-related methyltransferase in mammals, called GLP/Eu-HMTase1. Here we show that GLP is also important for H3-K9 methylation of mouse euchromatin. GLP-deficiency led to embryonic lethality, a severe reduction of H3-K9 mono- and dimethylation, the induction of Mage-a gene expression, and HP1 relocalization in embryonic stem cells, all of which were phenotypes of G9a-deficiency. Furthermore, we show that G9a and GLP formed a stoichiometric heteromeric complex in a wide variety of cell types. Biochemical analyses revealed that formation of the G9a/GLP complex was dependent on their enzymatic SET domains. Taken together, our new findings revealed that G9a and GLP cooperatively exert H3-K9 methyltransferase function in vivo, likely through the formation of higher-order heteromeric complexes.

  11. Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Aishu; Qiu, Yu [Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, 401147 (China); Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, 401147 (China); Cui, Hongjuan [State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716 (China); Fu, Gang, E-mail: fg.ras@hotmail.com [Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, 401147 (China); Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, 401147 (China)

    2015-03-27

    Objective: To explore whether inhibition of H3K9 Methyltransferase G9a could exert an antitumoral effect in oral squamous cell carcinoma (OSCC). Materials and methods: First we checked G9a expression in two OSCC cell lines Tca8113 and KB. Next we used a special G9a inhibitor BIX01294 (BIX) to explore the effect of inhibition of G9a on OSCC in vitro. Cell growth was tested by typlan blue staining, MTT assay and Brdu immunofluorescence staining. Cell autophagy was examined by monodansylcadaverine (MDC) staining, LC3-II immunofluorescence staining and LC3-II western blot assay. Cell apoptosis was checked by FITC Annexin-V and PI labeling, tunnel staining and caspase 3 western blot assay. Finally, the effect of inhibition of G9a on clonogenesis and tumorigenesis capacity of OSCC was analyzed by soft agar growth and xenograft model. Results: Here we showed that G9a was expressed in both Tca8113 and KB cells. Inhibition of G9a using BIX significantly reduced cell growth and proliferation in Tca8113 and KB. Inhibition of G9a induced cell autophagy with conversion of LC3-I to LC3-II and cell apoptosis with the expression of cleaved caspase 3. We also found that inhibition of G9a reduced colony formation in soft agar and repressed tumor growth in mouse xenograph model. Conclusion: Our results suggested that G9a might be a potential epigenetic target for OSCC treatment. - Highlights: • Inhibition of G9a reduced cell growth and proliferation in OSCC cells. • Inhibition of G9a induces autophagy and apoptosis in OSCC cells. • Inhibition of G9a repressed tumor growth in mouse xenograph model.

  12. 78 FR 47717 - The Violence Against Women Reauthorization Act of 2013: Overview of Applicability to HUD Programs

    Science.gov (United States)

    2013-08-06

    ... development of regulations or guidance, or both, as may be applicable. A. Coverage for Victims of Sexual... URBAN DEVELOPMENT The Violence Against Women Reauthorization Act of 2013: Overview of Applicability to... of General Counsel, Department of Housing and Urban Development, 451 7th Street SW., Room...

  13. Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution

    Science.gov (United States)

    Ding, Rui; Jin, Yongtang; Liu, Xinneng; Ye, Huaizhuang; Zhu, Ziyi; Zhang, Yuan; Wang, Ting; Xu, Yinchun

    2017-01-01

    As an important risk factor of respiratory disorders, traffic-related air pollution (TRAP) has caused extensive concerns. Epigenetic change has been considered a link between TRAP and respiratory diseases. However, the exact effects of TRAP on epigenetic changes are still unclear. Here we investigated the dose- and time- effect responses of TRAP on DNA methylations and H3K9 acetylation (H3K9ac) in both blood and lung tissues of rats. The findings showed that every 1 μg/m3 increase of TRAP components were associated with changes in %5 mC (95% CI) in LINE-1, iNOS, p16CDKN2A, and APC ranging from −0.088% (−0.150, −0.026) to 0.102 (0.049, 0.154), as well as 0.276 (0.053, 0.498) to 0.475 (0.103, 0.848) ng/mg increase of H3K9ac. In addition, every 1 more day exposure at high level of TRAP (in tunnel) also significantly changed the levels of DNA methylation (ranging from −0.842% to 0.248%) and H3K9ac (16.033 and 15.718 ng/mg pro in PBMC and lung tissue, respectively) changes. Season and/or sex could interact with air pollutants in affecting DNA methylation and H3K9ac. The findings showed that TRAP exposure is dose- and time- dependently associated with the changes of DNA methylation and H3K9ac. PMID:28256616

  14. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.

    Science.gov (United States)

    Valle-García, David; Qadeer, Zulekha A; McHugh, Domhnall S; Ghiraldini, Flávia G; Chowdhury, Asif H; Hasson, Dan; Dyer, Michael A; Recillas-Targa, Félix; Bernstein, Emily

    2016-06-02

    ATRX is a SWI/SNF chromatin remodeler proposed to govern genomic stability through the regulation of repetitive sequences, such as rDNA, retrotransposons, and pericentromeric and telomeric repeats. However, few direct ATRX target genes have been identified and high-throughput genomic approaches are currently lacking for ATRX. Here we present a comprehensive ChIP-sequencing study of ATRX in multiple human cell lines, in which we identify the 3' exons of zinc finger genes (ZNFs) as a new class of ATRX targets. These 3' exonic regions encode the zinc finger motifs, which can range from 1-40 copies per ZNF gene and share large stretches of sequence similarity. These regions often contain an atypical chromatin signature: they are transcriptionally active, contain high levels of H3K36me3, and are paradoxically enriched in H3K9me3. We find that these ZNF 3' exons are co-occupied by SETDB1, TRIM28, and ZNF274, which form a complex with ATRX. CRISPR/Cas9-mediated loss-of-function studies demonstrate (i) a reduction of H3K9me3 at the ZNF 3' exons in the absence of ATRX and ZNF274 and, (ii) H3K9me3 levels at atypical chromatin regions are particularly sensitive to ATRX loss compared to other H3K9me3-occupied regions. As a consequence of ATRX or ZNF274 depletion, cells with reduced levels of H3K9me3 show increased levels of DNA damage, suggesting that ATRX binds to the 3' exons of ZNFs to maintain their genomic stability through preservation of H3K9me3.

  15. MapGIS K9投影变换在国土资源“一张图”中的应用研究%Research on the Apptication of MapGIS k9 Projection Transformation in Lamd Resources A Map

    Institute of Scientific and Technical Information of China (English)

    钟世彬; 胡水平; 闫喜凤

    2011-01-01

    This paper firmly introduced the I luir*ctrri*lic? Of MapOIS K9 projection tranaformalion. "Own il foruiwd on the application c the coordinate import,coordinate transformation,and dynamic projection in I.mil Resource* A Map. It was proved tli.it MapGIS K9 can improve efficiency and quality of Land Resourcr* A Mup.%介绍了MapGIS K9投影变换特点,重点阐述了坐标导入、坐标特换和动态投影在国土资源“一张图”中的应用实例.通过试验验证,MapGIS K9有利于提高国土资源“一张国”工程建设效率与质量.

  16. ANSYS在脉冲CO2激光对K9玻璃损伤过程模拟中的应用研究%Application of ANSYS in Simulation Process of Pulse CO2 Laser Damage of K9 Glass

    Institute of Scientific and Technical Information of China (English)

    王玺; 李化; 聂劲松

    2008-01-01

    从脉冲CO2激光损伤K9玻璃有限元模型的建立和网格划分、脉冲激光的加载、设置初始条件和边界条件等几个方面,分析了基于ANSYS的脉冲CO2激光损伤K9玻璃模拟过程中的一些关键问题,建立了脉冲CO2激光损伤K9玻璃的有限元模型,对K9玻璃受到脉冲CO2激光辐照时的温度和应力分布进行了数值分析.

  17. Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development

    DEFF Research Database (Denmark)

    Pedersen, Marianne Terndrup; Kooistra, Susanne Marije; Radzisheuskaya, Aliaksandra

    2016-01-01

    Chromatin-associated proteins are essential for the specification and maintenance of cell identity. They exert these functions through modulating and maintaining transcriptional patterns. To elucidate the functions of the Jmjd2 family of H3K9/H3K36 histone demethylases, we generated conditional J...... demethylases represents a novel mechanism ensuring transcriptional competence and stability of the pluripotent cell identity....

  18. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9

    Science.gov (United States)

    Dhayalan, Arunkumar; Tamas, Raluca; Bock, Ina; Tattermusch, Anna; Dimitrova, Emilia; Kudithipudi, Srikanth; Ragozin, Sergey; Jeltsch, Albert

    2011-01-01

    Mutations in the ATRX protein are associated with the alpha-thalassemia and mental retardation X-linked syndrome (ATR-X). Almost half of the disease-causing mutations occur in its ATRX-Dnmt3-Dnmt3L (ADD) domain. By employing peptide arrays, chromatin pull-down and peptide binding assays, we show specific binding of the ADD domain to H3 histone tail peptides containing H3K9me3. Peptide binding was disrupted by the presence of the H3K4me3 and H3K4me2 modification marks indicating that the ATRX-ADD domain has a combined readout of these two important marks (absence of H3K4me2 and H3K4me3 and presence of H3K9me3). Disease-causing mutations reduced ATRX-ADD binding to H3 tail peptides. ATRX variants, which fail in the H3K9me3 interaction, show a loss of heterochromatic localization in cells, which indicates the chromatin targeting function of the ADD domain of ATRX. Disruption of H3K9me3 binding may be a general pathogenicity pathway of ATRX mutations in the ADD domain which may explain the clustering of disease mutations in this part of the ATRX protein. PMID:21421568

  19. 固结磨料化学机械研抛K9玻璃的材料去除机理

    Institute of Scientific and Technical Information of China (English)

    刘大伟; 巨金艳

    2015-01-01

    固结磨料化学机械磨料研抛K9材料取出的时候,其机械性能和化学作用是相互分离的,同时在处理的过程中对工件表面的硬度也会产生非常重大的影响.相关的研究已经显示研抛液能够和K9玻璃产生非常行明显的化学反应,同时能够起到保护的作用,在去除K9材料的时候是随着浸泡时间的增长而增长的,其去除的主要方式是脆性去除.主要分析了固结磨料化学机械研抛K9玻璃的材料去除机理,以供参考和借鉴.

  20. Biodegradation of malachite green by strain Pseudomonas sp. K9 and cloning of the tmr2 gene associated with an ISPpu12.

    Science.gov (United States)

    Huan-Mei; Lian-Tai, Li; Cai-Fang, Yan; Jin-Jin, Sun; Yuan-Gao; Hong, Qing; Shun-Peng, Li

    2011-06-01

    A bacterial strain K9 capable of degrading malachite green was isolated from the sludge of the wastewater treatment system of a chemical plant. It was identified preliminarily as Pseudomonas sp. Strain K9 was also able to degrade other triphenylmethane dyes, such as Crystal Violet and Basic Fuchsin. The gene tmr2, encoding the triphenylmethane reductase, was cloned from strain K9, and functionally expressed in E. coli. A 5946-bp DNA fragment including the tmr2 gene was cloned from the genomic DNA of strain K9 by chromosome walking. Its sequence analysis showed that tmr2 was associated with a typical mobile element ISPpu12 consisting of tnpA (encoding a transposase), lspA (encoding a lipoprotein signal peptidase) and orf1 (encoding a putative MerR family regulator), orf2 (encoding a CDF family heavy metal/H(+) antiporter). This association was also found in another malachite green-degrading strain Pseudomonas sp. MDB-1, which indicated that the tmr2 gene might be a horizontally transferable gene.

  1. 高丽神话——韩国K9“雷声”自行式榴弹炮

    Institute of Scientific and Technical Information of China (English)

    国武

    2007-01-01

    1999年,韩国陆军装备了自行研制的K9“雷声”(Thunder52倍口径155毫米自行式榴弹炮,成为亚洲第一个、世界第二个正式装备52倍口径155毫米自行榴弹炮的国家。“墙内开花,墙外也香”,除了在2001年8月与土耳其签订的价值10亿美元的K9火炮出口合同外,K9连同法国的“恺撒”及瑞典的FH77已赫然出现在亚太地区国家陆军优先考虑采购的新型重型火炮系统清单中。韩国K9自行式榴弹炮已经冲出亚洲,逐步走向世界了。

  2. 高丽神话——记韩国K9“雷声”自行式榴弹炮

    Institute of Scientific and Technical Information of China (English)

    肖咏捷

    2006-01-01

    1999年,韩国陆军装备了自行研制的K9“雷声”(Thunder)52倍口径155毫米自行式榴弹炮,成为亚洲第一个、世界第二个正式装备52倍口径155毫米自行榴弹炮的国家。墙内开花墙外也香,除了在2001年8月与土耳其签订的价值10亿美元的K9火炮出口合同外,K9连同法国的“凯撒”及瑞典的FH-77已赫然出现在亚太地区国家陆军优先考虑采购的新型重型火炮系统清单中。韩国K9自行式榴弹炮忆经冲出亚洲,逐渐走向世界了。

  3. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.

    Science.gov (United States)

    Dhayalan, Arunkumar; Tamas, Raluca; Bock, Ina; Tattermusch, Anna; Dimitrova, Emilia; Kudithipudi, Srikanth; Ragozin, Sergey; Jeltsch, Albert

    2011-06-01

    Mutations in the ATRX protein are associated with the alpha-thalassemia and mental retardation X-linked syndrome (ATR-X). Almost half of the disease-causing mutations occur in its ATRX-Dnmt3-Dnmt3L (ADD) domain. By employing peptide arrays, chromatin pull-down and peptide binding assays, we show specific binding of the ADD domain to H3 histone tail peptides containing H3K9me3. Peptide binding was disrupted by the presence of the H3K4me3 and H3K4me2 modification marks indicating that the ATRX-ADD domain has a combined readout of these two important marks (absence of H3K4me2 and H3K4me3 and presence of H3K9me3). Disease-causing mutations reduced ATRX-ADD binding to H3 tail peptides. ATRX variants, which fail in the H3K9me3 interaction, show a loss of heterochromatic localization in cells, which indicates the chromatin targeting function of the ADD domain of ATRX. Disruption of H3K9me3 binding may be a general pathogenicity pathway of ATRX mutations in the ADD domain which may explain the clustering of disease mutations in this part of the ATRX protein.

  4. Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2 in human oral cancer cell line.

    Directory of Open Access Journals (Sweden)

    Daisuke Yamamoto

    Full Text Available BACKGROUND: Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ in human oral cancer cell line resulted in accumulation of decarboxylated S-adenosylmethionine (dcSAM, which acts as a competitive inhibitor of methylation reactions. We anticipated that accumulation of dcSAM impaired methylation reactions and resulted in hypomethylation of genome DNA and histone tails. METHODOLOGY/PRINCIPAL FINDINGS: Global methylation state of genome DNA and lysine residues of histone H3 and H4 tails were assayed by Methylation by Isoschizomers (MIAMI method and western blotting, respectively, in the presence or absence of OAZ expression. Ectopic expression of OAZ mediated hypomethylation of CpG islands of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2. Protein level of DNA methyltransferase 3B (DNMT3B and histone H3K9me specific methyltransferase G9a were down-regulated in OAZ transfectant. CONCLUSIONS/SIGNIFICANCE: OAZ induced hypomethylation of CpG islands of global genome DNA and H3K9me2 by down-regulating DNMT3B and G9a protein level. Hypomethylation of CpG islands of genome DNA and histone H3K9me2 is a potent mechanism of induction of the genes related to tumor suppression and DNA double strand break repair.

  5. Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

    Science.gov (United States)

    Bulut-Karslioglu, Aydan; De La Rosa-Velázquez, Inti A; Ramirez, Fidel; Barenboim, Maxim; Onishi-Seebacher, Megumi; Arand, Julia; Galán, Carmen; Winter, Georg E; Engist, Bettina; Gerle, Borbala; O'Sullivan, Roderick J; Martens, Joost H A; Walter, Jörn; Manke, Thomas; Lachner, Monika; Jenuwein, Thomas

    2014-07-17

    Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP sequencing in mouse embryonic stem cells (ESCs). Refined bioinformatic analyses of repeat subfamilies indicated selective accumulation of Suv39h-dependent H3K9me3 at interspersed repetitive elements that cover ∼5% of the ESC epigenome. The majority of the ∼8,150 intact long interspersed nuclear elements (LINEs) and endogenous retroviruses (ERVs), but only a minor fraction of the >1.8 million degenerate and truncated LINEs/ERVs, are enriched for Suv39h-dependent H3K9me3. Transcriptional repression of intact LINEs and ERVs is differentially regulated by Suv39h and other chromatin modifiers in ESCs but governed by DNA methylation in committed cells. These data provide a function for Suv39h-dependent H3K9me3 chromatin to specifically repress intact LINE elements in the ESC epigenome.

  6. NASA thunderstorm overflight program: Atmospheric electricity research. An overview report on the optical lightning detection experiment for spring and summer 1983

    Science.gov (United States)

    Vaughan, O. H., Jr.

    1984-01-01

    This report presents an overview of the NASA Thunderstorm Overflight Program (TOP)/Optical Lightning Experiment (OLDE) being conducted by the Marshall Space Flight Center and university researchers in atmospheric electricity. Discussed in this report are the various instruments flown on the NASA U-2 aircraft, as well as the ground instrumentation used in 1983 to collect optical and electronic signatures from the lightning events. Samples of some of the photographic and electronic signatures are presented. Approximately 4132 electronic data samples of optical pulses were collected and are being analyzed by the NASA and university researchers. A number of research reports are being prepared for future publication. These reports will provide more detailed data analysis and results from the 1983 spring and summer program.

  7. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome

    Science.gov (United States)

    Zhang, Haoyue; Sun, Linlin; Wang, Kun; Wu, Di; Trappio, Mason; Witting, Celeste; Cao, Kan

    2016-01-01

    Compelling evidence suggests that defective DNA damage response (DDR) plays a key role in the premature aging phenotypes in Hutchinson-Gilford progeria syndrome (HGPS). Studies document widespread alterations in histone modifications in HGPS cells, especially, the global loss of histone H3 trimethylated on lysine 9 (H3K9me3). In this study, we explore the potential connection(s) between H3K9me3 loss and the impaired DDR in HGPS. When cells are exposed to a DNA-damaging agent Doxorubicin (Dox), double strand breaks (DSBs) are generated that result in the phosphorylation of histone H2A variant H2AX (gammaH2AX) within an hour. We find that the intensities of gammaH2AX foci appear significantly weaker in the G0/G1 phase HGPS cells compared to control cells. This reduction is associated with a delay in the recruitment of essential DDR factors. We further demonstrate that ataxia-telangiectasia mutated (ATM) is responsible for the amplification of gammaH2AX signals at DSBs during G0/G1 phase, and its activation is inhibited in the HGPS cells that display significant loss of H3K9me3. Moreover, methylene (MB) blue treatment, which is known to save heterochromatin loss in HGPS, restores H3K9me3, stimulates ATM activity, increases gammaH2AX signals and rescues deficient DDR. In summary, this study demonstrates an early DDR defect of attenuated gammaH2AX signals in G0/G1 phase HGPS cells and provides a plausible connection between H3K9me3 loss and DDR deficiency. PMID:27907109

  8. Repeat Composition of CenH3-chromatin and H3K9me2-marked heterochromatin in Sugar Beet (Beta vulgaris).

    Science.gov (United States)

    Kowar, Teresa; Zakrzewski, Falk; Macas, Jiří; Kobližková, Andrea; Viehoever, Prisca; Weisshaar, Bernd; Schmidt, Thomas

    2016-05-26

    Sugar beet (Beta vulgaris) is an important crop of temperate climate zones, which provides nearly 30 % of the world's annual sugar needs. From the total genome size of 758 Mb, only 567 Mb were incorporated in the recently published genome sequence, due to the fact that regions with high repetitive DNA contents (e.g. satellite DNAs) are only partially included. Therefore, to fill these gaps and to gain information about the repeat composition of centromeres and heterochromatic regions, we performed chromatin immunoprecipitation followed by sequencing (ChIP-Seq) using antibodies against the centromere-specific histone H3 variant of sugar beet (CenH3) and the heterochromatic mark of dimethylated lysine 9 of histone H3 (H3K9me2). ChIP-Seq analysis revealed that active centromeres containing CenH3 consist of the satellite pBV and the Ty3-gypsy retrotransposon Beetle7, while heterochromatin marked by H3K9me2 exhibits heterogeneity in repeat composition. H3K9me2 was mainly associated with the satellite family pEV, the Ty1-copia retrotransposon family Cotzilla and the DNA transposon superfamily of the En/Spm type. In members of the section Beta within the genus Beta, immunostaining using the CenH3 antibody was successful, indicating that orthologous CenH3 proteins are present in closely related species within this section. The identification of repetitive genome portions by ChIP-Seq experiments complemented the sugar beet reference sequence by providing insights into the repeat composition of poorly characterized CenH3-chromatin and H3K9me2-heterochromatin. Therefore, our work provides the basis for future research and application concerning the sugar beet centromere and repeat-rich heterochromatic regions characterized by the presence of H3K9me2.

  9. A quick solution structure determination of the fully oxidized double mutant K9-10A cytochrome c7 from Desulfuromonas acetoxidans and mechanistic implications.

    Science.gov (United States)

    Assfalg, Michael; Bertini, Ivano; Turano, Paola; Bruschi, Mireille; Durand, Marie-Claire; Giudici-Orticoni, Marie-Thérèse; Dolla, Alain

    2002-02-01

    Lysines 9 and 10 in Desulfuromonas acetoxidans cytochrome c7, which could be involved in the interaction mechanism with the redox partners, have been replaced by alanine residues using site-directed mutagenesis. The solution structure of the fully oxidized form of K9-10A cytochrome c7, which is paramagnetic with three paramagnetic centers, has been determined via 1H NMR. The assignment of the spectra has been performed through an automatic program whose algorithm and strategy are here described. The assignment of the NOESY spectra has been further extended by back calculating the NOESY maps. The final number of meaningful NOE-based upper distance limits was 1186. In the Restrained Energy Minimization calculations, 147 pseudocontact shift constraints were also included, which showed consistency with NOE-based constraints and therefore further contribute to validate the structure quality. A final family of 35 conformers was calculated with RMSD values with respect to the mean structure of 0.69 +/- 0.17 A and 1.05 +/- 0.14 A for the backbone and heavy atoms, respectively. The overall fold of the molecule is maintained with respect to the native protein. The loop present between heme III and heme IV results to be highly disordered also in the present structure although its overall shape mainly resembles that of the oxidized native protein, and the two strands which give rise to the short beta-sheet present at the N-terminus and connected by a turn containing the mutated residues, are less clearly defined. If this loop is neglected, the RMSD values are 0.52 +/- 0.07 A and 0.92 +/- 0.06 A for the backbone and heavy atoms, respectively, which represent a reasonable resolution. The relative distances and orientations of the three hemes are maintained, as well as the orientation of the imidazole rings of the axial histidine ligands, with the only exception of heme IV. Such difference probably reflects minor conformational changes due to the substitution of the vicinal Lys

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference Registry Login SCR Training and Testing Cancer Cancer Programs Cancer Programs Overview of Cancer Programs Cancer Programs News American Joint Committee on ...

  11. A New Model Program for Academically Gifted Students in Turkey: Overview of the Education Program for the Gifted Students' Bridge with University (EPGBU)

    Science.gov (United States)

    Tortop, Hasan Said

    2013-01-01

    All over the world, studies related to design of appropriate educational programs for gifted students have been continuing. It is also important that these programs should be adapted to both realities of countries and developing educational technologies. In Turkey, the structure of The Education Program for the Gifted Students' Bridge with…

  12. Optimization of K9 Glass Film as Protection for Erbium-Doped Phosphate Glass Surface during Ion-Exchange Processing%K9玻璃薄膜对离子交换磷酸盐玻璃波导表面保护的优化研究

    Institute of Scientific and Technical Information of China (English)

    韩秀友; 初凤红; 蔡海文; 方祖捷; 赵明山

    2008-01-01

    采用镀K9玻璃薄膜方法来解决离子交换掺铒磷酸盐玻璃波导表面的侵蚀问题,对K9玻璃薄膜的厚度进行了优化研究.测量分析了样品的荧光光谱和荧光寿命,采用光学显微镜和棱镜耦合技术对不同K9玻璃薄膜厚度下制备波导的表面形貌和导光特性进行了表征和测试.结果表明,与掺铒磷酸盐玻璃原材料相比,镀K9玻璃薄膜后荧光光谱保持不变,荧光寿命稍有下降(约0.2 ms);K9玻璃薄膜的厚度在60~80 nm的范围内保护效果最佳.为下一步制备掺铒有源玻璃光波导器件奠定了良好的实验基础.

  13. Overview of Student Characteristics and Program Outcomes. HEP/CAMP National Evaluation Project. Research Report No. 2.

    Science.gov (United States)

    Riley, Gary L.; And Others

    This research report is a detailed summary of student backgrounds, family characteristics, and educational and career outcomes of the respondents in the 1984-85 High School Equivalency Programs (HEP) and College Assistance for Migrants Programs (CAMP) National Evaluation Project. The report indicates that approximately half the HEP/CAMP…

  14. State ICC Overview: Policies, Programs, and Practices of State Interagency Coordinating Councils under the Individuals with Disabilities Education Act.

    Science.gov (United States)

    Shackelford, Jo, Ed.

    This document presents general information about State Interagency Coordinating Councils (SICCs) which participate in the Early Intervention Program for Infants and Toddlers with Disabilities (formerly Part H Program, now Part C) under the Individuals with Disabilities Education Act (IDEA). The information was gathered from questionnaires returned…

  15. The role of Ser54 in the antinociceptive activity of BmK9, a neurotoxin from the scorpion Buthus martensii Karsch.

    Science.gov (United States)

    Wang, Yueqiu; Hao, Zhihui; Shao, Jianhua; Song, Yongbo; Li, Chunli; Li, Chuan; Zhao, Yongshan; Liu, Yanfeng; Wei, Tingting; Wu, Chunfu; Zhang, Jinghai

    2011-11-01

    Residue 54 has been shown to be important for bioactivity in several toxins. However, its role in the antinociceptive activity of toxins has not been evaluated yet. In this study, site-directed mutagenesis and mouse acetic acid writhing test were used to investigate the role of Ser54 in the antinociceptive activity of BmK9 neurotoxin from the Buthus martensii Karsch scorpion. Detailed mutagenesis analysis revealed that substitution of Ser54 by various polar amino acids produced no significant change in the antinociceptive activity, while all substitutions of nonpolar amino acid for Ser54 led to a significant loss of antinociceptive activity. Following the conformational analysis, it was suggested that Ser54 in BmK9 plays a functional role in the antinociceptive activity, the residue exerts its effect by means of a side-chain hydrogen bond.

  16. Catalytic roles of lysines (K9, K27, K31) in the N-terminal domain in human adenylate kinase by random site-directed mutagenesis.

    Science.gov (United States)

    Ayabe, T; Park, S K; Takenaka, H; Sumida, M; Uesugi, S; Takenaka, O; Hamada, M

    1996-11-01

    To elucidate lysine residues in the N-terminal domain of human cytosolic adenylate kinase (hAK1, EC 2.7.4.3), random site-directed mutagenesis of K9, K27, and K31 residues was performed, and six mutants were analyzed by steady-state kinetics. K9 residue may play an important role in catalysis by interacting with AMP2-. K27 and K31 residues appear to play a functional role in catalysis by interacting with MgATP2-. In human AK, the epsilon-amino group in the side chain of these lysine residues would be essential for phosphoryl transfer between MgATP2- and AMP2- during transition state.

  17. Study of methyl transferase (G9aMT) and methylated histone (H3-K9) expressions in unexplained recurrent spontaneous abortion (URSA) and normal early pregnancy.

    Science.gov (United States)

    Fatima, Nishat; Ahmed, S H; Salhan, Sudha; Rehman, S M F; Kaur, Jatinder; Owais, M; Chauhan, Shyam S

    2011-11-01

    We investigated the expression of methyl transferase G9a and methylated histone H3-K9 in fresh human decidual/endometrial tissue of 12 normal early pregnancies and 15 unexplained recurrent spontaneous abortions (URSA). The samples were obtained through dilatation and curettage and collected as per strict inclusion-exclusion criteria. The tissue was subjected to immunohistochemical analysis (IHC), western blotting (WB) and RT-PCR analysis. The results demonstrated methyl transferase G9a to have a lower expression in abortions when compared with that in normal pregnancy (P K9 was significantly lower (P < 0.0001) in URSA tissues than in controls. This study suggests that methylation may cause URSA and indicates the need for further work to explore the role of methylation in URSA and its possible prevention through locally acting methylating/demethylating agents.

  18. High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin.

    Science.gov (United States)

    Schalch, Thomas; Job, Godwin; Noffsinger, Victoria J; Shanker, Sreenath; Kuscu, Canan; Joshua-Tor, Leemor; Partridge, Janet F

    2009-04-10

    In fission yeast, assembly of centromeric heterochromatin requires the RITS complex, which consists of Ago1, Tas3, Chp1, and siRNAs derived from centromeric repeats. Recruitment of RITS to centromeres has been proposed to depend on siRNA-dependent targeting of Ago1 to centromeric sequences. Previously, we demonstrated that methylated lysine 9 of histone H3 (H3K9me) acts upstream of siRNAs during heterochromatin establishment. Our crystal structure of Chp1's chromodomain in complex with a trimethylated lysine 9 H3 peptide reveals extensive sites of contact that contribute to Chp1's high-affinity binding. We found that this high-affinity binding is critical for the efficient establishment of centromeric heterochromatin, but preassembled heterochromatin can be maintained when Chp1's affinity for H3K9me is greatly reduced.

  19. Swiss Energy research 2007 - Overview from the Heads of the Programs; Energie-Forschung 2007. Ueberblicksberichte der Programmleiter

    Energy Technology Data Exchange (ETDEWEB)

    Calisesi, Y.

    2008-04-15

    This comprehensive document issued by the Swiss Federal Office of Energy (SFOE) presents the overview reports elaborated by the heads of the various Swiss energy research programmes. Topics covered include the efficient use of energy, with reports covering energy in buildings, traffic and accumulators, electrical technologies, applications and grids, ambient heat, combined heat and power, cooling, combustion, the 'power station 2000', fuel cells and hydrogen and process engineering. Renewable energy topics reported on include solar heat, photovoltaics, industrial solar energy, biomass and wood energy, hydropower, geothermal heat and wind energy. Nuclear energy topics include safety, regulatory safety research and nuclear fusion. Finally, energy economics basics are reviewed. The report is completed with annexes on the Swiss Energy Research Commission, energy research organisations and a list of important addresses.

  20. ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients

    Energy Technology Data Exchange (ETDEWEB)

    Sui, W.G. [Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department, 181st Hospital, Guilin, Guangxi (China); He, H.Y. [The Life Science College, Guangxi Normal University, Guilin, Guangxi (China); Yan, Q.; Chen, J.J. [Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department, 181st Hospital, Guilin, Guangxi (China); Zhang, R.H. [The Life Science College, Guangxi Normal University, Guilin, Guangxi (China); Dai, Y. [Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University, Shenzhen, Guangdong (China)

    2013-12-12

    Membranous nephropathy (MN), characterized by the presence of diffuse thickening of the glomerular basement membrane and subepithelial in situ immune complex disposition, is the most common cause of idiopathic nephrotic syndrome in adults, with an incidence of 5-10 per million per year. A number of studies have confirmed the relevance of several experimental insights to the pathogenesis of human MN, but the specific biomarkers of MN have not been fully elucidated. As a result, our knowledge of the alterations in histone methylation in MN is unclear. We used chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) to analyze the variations in a methylated histone (H3K9me3) in peripheral blood mononuclear cells from 10 MN patients and 10 healthy subjects. There were 108 genes with significantly different expression in the MN patients compared with the normal controls. In MN patients, significantly increased activity was seen in 75 H3K9me3 genes, and decreased activity was seen in 33, compared with healthy subjects. Five positive genes, DiGeorge syndrome critical region gene 6 (DGCR6), sorting nexin 16 (SNX16), contactin 4 (CNTN4), baculoviral IAP repeat containing 3 (BIRC3), and baculoviral IAP repeat containing 2 (BIRC2), were selected and quantified. There were alterations of H3K9me3 in MN patients. These may be candidates to help explain pathogenesis in MN patients. Such novel findings show that H3K9me3 may be a potential biomarker or promising target for epigenetic-based MN therapies.

  1. 基于MapGIS K9的农村集体土地所有权建库研究

    Institute of Scientific and Technical Information of China (English)

    李扬帆

    2014-01-01

    在农村集体土地所有权确权登记发证项目中,需要进行数据库建设。介绍了MapGIS K9平台的功能及数据库建设流程,分析了数据要求及数据检查应该注意的问题。

  2. Final report of the key comparison APMP.QM-K9: APMP comparison on pH measurement of phosphate buffer

    Science.gov (United States)

    Hioki, Akiharu; Ohata, Masaki; Cherdchu, Chainarong; Tangpaisarnkul, Nongluck

    2011-01-01

    The APMP.QM-K9 was organised by TCQM of APMP to test the abilities of the national metrology institutes in the APMP region to measure a pH value of a phosphate buffer. This APMP comparison on pH measurement was proposed by the National Metrology Institute of Japan, NMIJ, and the National Institute of Metrology of Thailand, NIMT, in August 2009. After approval by TCQM, the comparison has been conducted by NMIJ and NIMT. The comparison is a key comparison following CCQM-K9, CCQM-K9.1 and CCQM-K9.2. The comparison material was a phosphate buffer of pH around 6.86 and the measurement temperatures were 15 °C, 25 °C and 37 °C. This is the first APMP key comparison on pH measurement and the third APMP comparison on pH measurement following APMP.QM-P06 (two phosphate buffers) in 2004 and APMP.QM-P09 (a phthalate buffer) in 2006. The results can be used further by any participant to support its CMC claim for a phosphate buffer. That claim will concern the pH method employed by the participant during this comparison and will cover the temperature(s) used or the full temperature range between 15 °C and 37 °C for the participant which measured pH values at the three temperatures. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  3. Dissolution behavior of bioactive glass ceramics with different CaO/MgO ratios in SBF-K9 and r-SBF$

    Institute of Scientific and Technical Information of China (English)

    M.U. Hashmi; Saqlain A. Shah

    2014-01-01

    In the present work, we studied dissolution behavior of three glass ceramics samples each having 34 SiO2-14.5 P2O5-1 CaF2-0.5 MgF2 (%wt) and ratio of CaO/MgO varying from 11.5:1 to 1:11.5 in conventional SBF (SBF-K9) and revised SBF (r-SBF) that has ionic concentration exactly equal to that of human blood plasma. For that purpose, samples were immersed in fluids for different time periods upto 25 days. Thin film XRD analysis revealed the diffusive nature of the phases on the surfaces of samples after soaking for different time periods in r-SBF. It showed the poor precipitation and small thickness of the HCAp layer on the samples as compared to that in SBF-K9, thus indicating the fitness and sensitivity of r-SBF for in-vitro characterization of samples. AAS, FTIR and EDS revealed slow bonding rate on the surfaces of the samples in r-SBF than that in SBF-K9 that showed the dependence of bond formation on the composition of the materials as well as on the physiological fluid used for in-vitro characterization. The rate of HCAp formation was slower in r-SBF due to more competitive adsorption of CO3- ions to Ca and Mg ions owing to greater amount of CO3- in r-SBF than that in SBF-K9. It shows the importance of CO3- content in the physiological fluids for the in-vitro assessment of samples. So, r-SBF is recommended to be used for assessment of samples to clearly understand their behavior in-vivo.

  4. Dissolution behavior of bioactive glass ceramics with different CaO/MgO ratios in SBF-K9 and r-SBF

    Directory of Open Access Journals (Sweden)

    M.U. Hashmi

    2014-08-01

    Full Text Available In the present work, we studied dissolution behavior of three glass ceramics samples each having 34 SiO2–14.5 P2O5–1 CaF2–0.5 MgF2 (%wt and ratio of CaO/MgO varying from 11.5:1 to 1:11.5 in conventional SBF (SBF-K9 and revised SBF (r-SBF that has ionic concentration exactly equal to that of human blood plasma. For that purpose, samples were immersed in fluids for different time periods upto 25 days. Thin film XRD analysis revealed the diffusive nature of the phases on the surfaces of samples after soaking for different time periods in r-SBF. It showed the poor precipitation and small thickness of the HCAp layer on the samples as compared to that in SBF-K9, thus indicating the fitness and sensitivity of r-SBF for in-vitro characterization of samples. AAS, FTIR and EDS revealed slow bonding rate on the surfaces of the samples in r-SBF than that in SBF-K9 that showed the dependence of bond formation on the composition of the materials as well as on the physiological fluid used for in-vitro characterization. The rate of HCAp formation was slower in r-SBF due to more competitive adsorption of CO3− ions to Ca and Mg ions owing to greater amount of CO3− in r-SBF than that in SBF-K9. It shows the importance of CO3− content in the physiological fluids for the in-vitro assessment of samples. So, r-SBF is recommended to be used for assessment of samples to clearly understand their behavior in-vivo.

  5. Growth of bultfonteinite and hydrogarnet in metasomatized basalt xenoliths in the B/K9 kimberlite, Damtshaa, Botswana: insights into hydrothermal metamorphism in kimberlite pipes

    Science.gov (United States)

    Buse, Ben; Schumacher, John C.; Sparks, R. Stephen J.; Field, Matthew

    2010-10-01

    Metamorphic assemblages within Karoo basalt xenoliths, found within volcaniclastic kimberlite of the B/K9 pipe, Damtshaa, Botswana, constrain conditions of kimberlite alteration. Bultfonteinite and chlorite partially replace the original augite-plagioclase assemblage, driven by the serpentinisation of the kimberlite creating strong chemical potential gradients for Si and Mg. Hydrogarnet and serpentine replace these earlier metamorphic assemblages as the deposits cool. The bultfonteinite (ideally Ca2SiO2[OH,F]4) and hydrogarnet assemblages require a water-rich fluid containing F-, and imply hydrothermal alteration dominated by external fluids rather than autometamorphism from deuteric fluids. Bultfonteinite and hydrogarnet are estimated to form at temperatures of ca. 350-250°C, which are similar to those for serpentinisation. Alteration within the B/K9 kimberlite predominantly occurs between 250 and 400°C. We attribute these conditions to increased efficiency of mass transfer and chemical reactions below the critical point of water and a consequence of volume-increasing serpentinisation and metasomatic reactions that take place over this temperature range. A comparison of the B/K9 kimberlite with kimberlites from Venetia, South Africa suggests that the composition and mineralogy of included xenoliths affects the alteration assemblages within kimberlite deposits.

  6. The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.

    Directory of Open Access Journals (Sweden)

    Elena Caro

    Full Text Available In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such as histone H3 lysine 9 (H3K9 methylation. In Arabidopsis thaliana, DNA methylation and H3K9 methylation are usually colocated and set up a mutually self-reinforcing and stable state. Here, in contrast, we found that SUVR5, a plant Su(var3-9 homolog with a SET histone methyltransferase domain, mediates H3K9me2 deposition and regulates gene expression in a DNA methylation-independent manner. SUVR5 binds DNA through its zinc fingers and represses the expression of a subset of stimulus response genes. This represents a novel mechanism for plants to regulate their chromatin and transcriptional state, which may allow for the adaptability and modulation necessary to rapidly respond to extracellular cues.

  7. 喉癌细胞系中抑癌基因MGMT表达与DNA甲基化及组蛋白H3-K9甲基化的关系%Correlation between histone H3-K9 methylation, DNA methylation and expression of gene MGMT in Hep-2 cell line

    Institute of Scientific and Technical Information of China (English)

    杨静; 何丽霞; 季文樾; 金明珠; 赵旭东

    2012-01-01

    To explore the correlation between histone H3-K9 methylation, DNA methylation and expression of carcinoma suppressor gene MGMT in laryngeal carcinoma Hep-2 cell line. Method: 5-Aza-dC was used to deal with Hep-2 cell cultured in vitro. ChIP, MSP and Realtime- PCR were used to detect H3-K9 methylation, DNA methylation, of MGMT gene promoter region and MGMT gene expression before and after treatment with drugs. Result: In Hep-2 cell line,gene MGMT was characterized by DNA methylation and histone H3-K9 hypermethylation. 5-Aza-dC was able to reduce H3-K9 methylation of MGMT gene histone in Hep-2 cell line, 5-Aza-dC was able to reverse DNA methylation of MGMT gene histone in Hep-2 cell line,5-Aza-dC was able to up-regulate the down-regulated gene expression of tumor suppressor genes MGMT. Conclusion: Promoter methylation of cancer suppressor gene MGMT may induce the gene inactivity. DNA methylation may increase H3-K9 methylation. 5-Aza-dC can reduce H3-K9 methylation of tumor suppressor gene MGMT histone by reversing DNA methylation of tumor suppressor gene MGMT, and then the expression of tumor suppressor genes is increased and tumor development is inhibited.%目的:探讨喉癌Hep-2细胞中组蛋白H3-K9甲基化与DNA甲基化及抑癌基因MGMT表达的关系.方法:应用去甲基化制剂5-氮杂-2'-脱氧胞苷(5-Aza-dC)处理体外培养的Hep-2细胞.应用染色质免疫沉淀技术、甲基化特异性聚合酶链反应和实时定量逆转录聚合酶链反应分析药物作用前后MGMT基因启动子区组蛋白H3-K9甲基化、DNA甲基化和MGMT表达情况.结果:①在Hep-2细胞未经药物干预前,MGMT表现为DNA甲基化,组蛋白H3-K9高甲基化,MGMT低表达.②在5-Aza-dC的作用下,Hep-2细胞中MGMT的组蛋白H3-K9甲基化状态被降低;MGMT的DNA甲基化状态得到了逆转;原来低表达的MGMT表达上调.结论:喉癌细胞系中MGMT启动子区甲基化可能是导致其基因失活的主要原因.DNA甲

  8. The INTERACT Quality Improvement Program: An Overview for Medical Directors and Primary Care Clinicians in Long-Term Care

    Science.gov (United States)

    Ouslander, Joseph G.; Bonner, Alice; Herndon, Laurie; Shutes, Jill

    2014-01-01

    INTERACT is a publicly available quality improvement program that focuses on improving the identification, evaluation, and management of acute changes in condition of nursing home residents. Effective implementation has been associated with substantial reductions in hospitalization of nursing home residents. Familiarity with and support of program implementation by medical directors and primary care clinicians in the nursing home setting are essential to effectiveness and sustainability of the program over time. In addition to helping nursing homes prevent unnecessary hospitalizations and their related complications and costs, and thereby continuing to be or becoming attractive partners for hospitals, health care systems, managed care plans, and ACOs, effective INTERACT implementation will assist nursing homes in meeting the new requirement for a robust QAPI program which is being rolled out by the federal government over the next year. PMID:24513226

  9. KiVa Antibullying Program: Overview of Evaluation Studies Based on a Randomized Controlled Trial and National Rollout in Finland

    Directory of Open Access Journals (Sweden)

    Christina Salmivalli

    2012-12-01

    Full Text Available The effects of a Finnish national school-based antibullying program (KiVa were evaluated in a randomized controlled trial (2007–2009 and during nationwide implementation (since 2009. The KiVa program is been found to reduce bullying and victimization and increase empathy towards victimized peers and self-efficacy to support and defend them. KiVa increases school liking and motivation and contributes to significant reductions in anxiety, depression, and negative peer perceptions. Somewhat larger reductions in bullying and victimization were found in the randomized controlled trial than in the broad rollout, and the largest effects were obtained in primary school (grades 1–6. The uptake of the KiVa program is remarkable, with 90 percent of Finnish comprehensive schools currently registered as program users.

  10. The NASA Electronic Parts and Packaging (NEPP) Program: Overview and the New Tenets for Cost Conscious Mission Assurance on Electrical, Electronic, and Electromechanical (EEE) Parts

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2015-01-01

    The NEPP Program focuses on the reliability aspects of electronic devices (integrated circuits such as a processor in a computer). There are three principal aspects of this reliability: 1) Lifetime, inherent failure and design issues related to the EEE parts technology and packaging; 2) Effects of space radiation and the space environment on these technologies, and; 3) Creation and maintenance of the assurance support infrastructure required for mission success. The NEPP mission is to provide guidance to NASA for the selection and application of microelectronics technologies, to improve understanding of the risks related to the use of these technologies in the space environment, and to ensure that appropriate EEE parts research is performed to meet NASA mission assurance needs. NEPPs FY15 goals are to represent the NASA voice to the greater aerospace EEE parts community including supporting anti-counterfeit and trust, provide relevant guidance to cost-effective missions, aid insertion of advanced (and commercial) technologies, resolve unexpected parts issues, ensure access to appropriate radiation test facilities, and collaborate as widely as possible with external entities. In accordance with the changing mission profiles throughout NASA, the NEPP Program has developed a balanced portfolio of efforts to provide agency-wide assurance for not only traditional spacecraft developments, but also those in-line with the new philosophies emerging worldwide. In this presentation, we shall present an overview of this program and considerations for EEE parts assurance as applied to cost conscious missions.

  11. Stroke: Overview

    Science.gov (United States)

    ... NICHD Research Information Clinical Trials Resources and Publications Stroke: Overview Skip sharing on social media links Share this: Page Content Stroke is a leading cause of disability and death ...

  12. Linking population, health, and the environment: an overview of integrated programs and a case study in Nepal.

    Science.gov (United States)

    Hahn, Sigrid; Anandaraja, Natasha; D'Agnes, Leona

    2011-01-01

    Population, health, and environment programs are cross-sectoral development initiatives that link conservation, health, and family planning interventions. These programs are generally located in biodiversity hotspots, where population pressure is among the factors contributing to environmental degradation. This review describes the general structure of population, health, and environment programs and provides selected examples to highlight various aspects of this approach. We focus in depth on a case study from the Integrating Population and Health into Forestry Management Agendas program in Nepal that simultaneously addressed deforestation from fuel-wood harvesting, indoor air pollution from wood fires, acute respiratory infections related to smoke inhalation, as well as family planning in communities in Nepal's densely populated forest corridors. Keys to the success of the Nepal project included empowerment of community forest user groups with population, health, and environment program know-how and appropriate technology. Lessons learned in Nepal point to the critical role that nongovernmental organizations can play as catalysts of cross-sectoral responses to complex development issues such as this one. The population, health, and environment approach can be an effective method for achieving sustainable development and meeting both conservation and health objectives.

  13. Investigation of Neutron-induced Reactions at n_TOF: an Overview of the 2009–2012 Experimental Program

    CERN Document Server

    Guerrero, C; Andrzejewski, J; Audouin, L; Barbagallo, M; Bécares, V; Bečvář, F; Belloni, F; Berthoumieux, E; Billowes, J; Boccone, V; Bosnar, D; Brugger, M; Calviani, M; Calviño, F; Cano-Ott, D; Carrapiço, C; Cerutti, F; Chiaveri, E; Chin, M; Colonna, N; Cortés, G; Cortés-Giraldo, M A; Diakaki, M; Domingo-Pardo, C; Duran, I; Dressler, R; Dzysiuk, N; Eleftheriadis, C; Ferrari, A; Fraval, K; Ganesan, S; García, A R; Giubrone, G; Gómez-Hornillos, M B; Gonçalves, I F; González-Romero, E; Griesmayer, E; Gunsing, F; Gurusamy, P; Jenkins, D G; Jericha, E; Kadi, Y; Käppeler, F; Karadimos, D; Kivel, N; Koehler, P; Kokkoris, M; Korschinek, G; Krtička, M; Kroll, J; Langer, C; Lederer, C; Leeb, H; Leong, L S; Losito, R; Manousos, A; Marganiec, J; Martínez, T; Mastinu, P F; Mastromarco, M; Massimi, C; Meaze, M; Mendoza, E; Mengoni, A; Milazzo, P M; Mingrone, F; Mirea, M; Mondelaers, W; Paradela, C; Pavlik, A; Perkowski, J; Pignatari, M; Plompen, A; Praena, J; Quesada, J M; Rauscher, T; Reifarth, R; Riego, A; Roman, F; Rubbia, C; Sarmento, R; Schillebeeckx, P; Schmidt, S; Schumann, D; Tagliente, G; Tain, J L; Tarrío, D; Tassan-Got, L; Tsinganis, A; Valenta, S; Vannini, G; Variale, V; Vaz, P; Ventura, A; Versaci, R; Vermeulen, M J; Vlachoudis, V; Vlastou, R; Wallner, A; Ware, T; Weigand, M; Weiß, C; Wright, T J; Žugec, P

    2014-01-01

    The neutron time-of-flight facility n\\_TOF is operating at CERN (Switzerland) since 2001, having started in 2009 a new campaign with an upgraded spallation target. The ambitious program carried out includes a large number of experiments in nuclear technology, astrophysics, basic physics, detector development and medical applications. This paper is devoted to the physics program at n\\_TOF and the measurements performed between 2009 and 2012. Special attention is given to those experiments that have been most challenging, are more important for a particular field, have reached unprecedented levels of accuracy, or have been carried out for the first time ever.

  14. An Overview of the Los Alamos Inertial Confinement Fusion and High-Energy-Density Physics Research Programs

    Energy Technology Data Exchange (ETDEWEB)

    Batha, Steven H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Physics Division

    2016-07-15

    The Los Alamos Inertial Confinement Fusion and Science Programs engage in a vigorous array of experiments, theory, and modeling. We use the three major High Energy Density facilities, NIF, Omega, and Z to perform experiments. These include opacity, radiation transport, hydrodynamics, ignition science, and burn experiments to aid the ICF and Science campaigns in reaching their stewardship goals. The ICF program operates two nuclear diagnostics at NIF, the neutron imaging system and the gamma reaction history instruments. Both systems are being expanded with significant capability enhancements.

  15. The Turkish Geography Teaching Program (2005) and Technology Use in Geography Courses: An Overview of High School Teachers' Approach

    Science.gov (United States)

    Incekara, Suleyman

    2011-01-01

    This study aims at assessing the importance and use of technology in geography courses, what the 2005 geography teaching program changed in terms of technology and some of the factors preventing the effective use of technology from teachers' perspectives. The research outcomes suggested that, despite the fact that there is a common consensus among…

  16. An overview of microbial food safety programs in beef, pork, and poultry from farm to processing in Canada.

    Science.gov (United States)

    Rajić, Andrijana; Waddell, Lisa A; Sargeant, Jan M; Read, Susan; Farber, Jeff; Firth, Martin J; Chambers, Albert

    2007-05-01

    Canada's vision for the agri-food industry in the 21st century is the establishment of a national food safety system employing hazard analysis and critical control point (HACCP) principles and microbiological verification tools, with traceability throughout the gate-to-plate continuum. Voluntary on-farm food safety (OFFS) programs, based in part on HACCP principles, provide producers with guidelines for good production practices focused on general hygiene and biosecurity. OFFS programs in beef cattle, swine, and poultry are currently being evaluated through a national recognition program of the Canadian Food Inspection Agency. Mandatory HACCP programs in federal meat facilities include microbial testing for generic Escherichia coli to verify effectiveness of the processor's dressing procedure, specific testing of ground meat for E. coli O157:H7, with zero tolerance for this organism in the tested lot, and Salmonella testing of raw products. Health Canada's policy on Listeria monocytogenes divides ready-to-eat products into three risk categories, with products previously implicated as the source of an outbreak receiving the highest priority for inspection and compliance. A national mandatory identification program to track livestock from the herd of origin to carcass inspection has been established. Can-Trace, a data standard for all food commodities, has been designed to facilitate tracking foods from the point of origin to the consumer. Although much work has already been done, a coherent national food safety strategy and concerted efforts by all stakeholders are needed to realize this vision. Cooperation of many government agencies with shared responsibility for food safety and public health will be essential.

  17. Histone H3 Acetyl K9 and Histone H3 Tri Methyl K4 as Prognostic Markers for Patients with Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Susanne Beyer

    2017-02-01

    Full Text Available Chromatin remodeling alters gene expression in carcinoma tissue. Although cervical cancer is the fourth most common cancer in women worldwide, a systematic study about the prognostic value of specific changes in the chromatin structure, such as histone acetylation or histone methylation, is missing. In this study, the expression of histone H3 acetyl K9, which is known to denote active regions at enhancers and promoters, and histone H3 tri methyl K4, which preferentially identifies active gene promoters, were examined as both show high metastatic potential. A panel of patients with cervical cancer was selected and the importance of the histone modifications concerning survival-time (overall survival and relapse-free survival was analyzed in 250 cases. Histone H3 acetyl K9 staining was correlated with low grading, low FIGO (TNM classification and the International Federation of Gynecology and Obstetrics status, negative N-status and low T-status in cervical cancer, showing a higher expression in adenocarcinoma than in squamous cell carcinoma. Cytoplasmic expression of histone H3 tri methyl K4 in a cervical cancer specimen was correlated with advanced T-status and poor prognosis. While cytoplasmic H3K4me3 expression seemed to be a marker of relapse-free survival, nuclear expression showed a correlation to poor prognosis in overall survival. Within this study, we analyzed the chemical modification of two histone proteins that are connected to active gene expression. Histone H3 acetyl K9 was found to be an independent marker of overall survival. Histone H3 tri methyl K4 was correlated with poor prognosis and it was found to be an independent marker of relapse-free survival. Therefore, we could show that chromatin remodeling plays an important role in cervical cancer biology.

  18. Histone H3 Acetyl K9 and Histone H3 Tri Methyl K4 as Prognostic Markers for Patients with Cervical Cancer.

    Science.gov (United States)

    Beyer, Susanne; Zhu, Junyan; Mayr, Doris; Kuhn, Christina; Schulze, Sandra; Hofmann, Simone; Dannecker, Christian; Jeschke, Udo; Kost, Bernd P

    2017-02-23

    Chromatin remodeling alters gene expression in carcinoma tissue. Although cervical cancer is the fourth most common cancer in women worldwide, a systematic study about the prognostic value of specific changes in the chromatin structure, such as histone acetylation or histone methylation, is missing. In this study, the expression of histone H3 acetyl K9, which is known to denote active regions at enhancers and promoters, and histone H3 tri methyl K4, which preferentially identifies active gene promoters, were examined as both show high metastatic potential. A panel of patients with cervical cancer was selected and the importance of the histone modifications concerning survival-time (overall survival and relapse-free survival) was analyzed in 250 cases. Histone H3 acetyl K9 staining was correlated with low grading, low FIGO (TNM classification and the International Federation of Gynecology and Obstetrics) status, negative N-status and low T-status in cervical cancer, showing a higher expression in adenocarcinoma than in squamous cell carcinoma. Cytoplasmic expression of histone H3 tri methyl K4 in a cervical cancer specimen was correlated with advanced T-status and poor prognosis. While cytoplasmic H3K4me3 expression seemed to be a marker of relapse-free survival, nuclear expression showed a correlation to poor prognosis in overall survival. Within this study, we analyzed the chemical modification of two histone proteins that are connected to active gene expression. Histone H3 acetyl K9 was found to be an independent marker of overall survival. Histone H3 tri methyl K4 was correlated with poor prognosis and it was found to be an independent marker of relapse-free survival. Therefore, we could show that chromatin remodeling plays an important role in cervical cancer biology.

  19. Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks.

    Directory of Open Access Journals (Sweden)

    Maria A Hahn

    Full Text Available To elucidate the relationship between intragenic DNA methylation and chromatin marks, we performed epigenetic profiling of chromosome 19 in human bronchial epithelial cells (HBEC and in the colorectal cancer cell line HCT116 as well as its counterpart with double knockout of DNMT1 and DNMT3B (HCT116-DKO. Analysis of H3K36me3 profiles indicated that this intragenic mark of active genes is associated with two categories of genes: (i genes with low CpG density and H3K9me3 in the gene body or (ii genes with high CpG density and DNA methylation in the gene body. We observed that a combination of low CpG density in gene bodies together with H3K9me3 and H3K36me3 occupancy is a specific epigenetic feature of zinc finger (ZNF genes, which comprise 90% of all genes carrying both histone marks on chromosome 19. For genes with high intragenic CpG density, transcription and H3K36me3 occupancy were not changed in conditions of partial or intensive loss of DNA methylation in gene bodies. siRNA knockdown of SETD2, the major histone methyltransferase responsible for production of H3K36me3, did not reduce DNA methylation in gene bodies. Our study suggests that the H3K36me3 and DNA methylation marks in gene bodies are established largely independently of each other and points to similar functional roles of intragenic DNA methylation and intragenic H3K9me3 for CpG-rich and CpG-poor genes, respectively.

  20. An overview of intravenous-related medication administration errors as reported to MEDMARX, a national medication error-reporting program.

    Science.gov (United States)

    Hicks, Rodney W; Becker, Shawn C

    2006-01-01

    Medication errors can be harmful, especially if they involve the intravenous (IV) route of administration. A mixed-methodology study using a 5-year review of 73,769 IV-related medication errors from a national medication error reporting program indicates that between 3% and 5% of these errors were harmful. The leading type of error was omission, and the leading cause of error involved clinician performance deficit. Using content analysis, three themes-product shortage, calculation errors, and tubing interconnectivity-emerge and appear to predispose patients to harm. Nurses often participate in IV therapy, and these findings have implications for practice and patient safety. Voluntary medication error-reporting programs afford an opportunity to improve patient care and to further understanding about the nature of IV-related medication errors.

  1. The first 7 years of the metropolitan fire brigade emergency responder program – an overview of incidents attended

    Science.gov (United States)

    Boyle, Malcolm J; Williams, Brett; Bibby, Colin; Morton, Allan; Huggins, Chris

    2010-01-01

    Purpose The Melbourne Metropolitan Fire and Emergency Services Board (MFESB) was the first fire service in Australia to implement a service-wide emergency medical response (EMR) program in 2001. No additional scientific analysis of the first responder program has been reported since the pilot program. The objective of this study was to report the first 7 years of responses by firefighters as first responders. Patients and methods The MFESB have three separate datasets with cardiac arrest information: (i) callout record; (ii) patient care record; and (iii) cardiac arrest record, including data from the automatic external defibrillator. Descriptive statistics were used to summarize the demographic and specific outcome data. Ethics approval was granted. Results A total of 8227 incidents were attended over the first 7 years. The most incidents attended were cardiac arrest 54% (n = 4450) followed by other medical 19% (n = 1579), and drug overdose 11% (n = 908); the remainder were <10% each. Sixty-three percent of incidents involved males. Average age was 57.2 years, median age 63 years, range from <1 month to 101 years; average response time was 6.1 minutes, median response time 5.6 minutes, range from 9 seconds to 31.5 minutes. Firefighters provided “initial care” in 57% and assisted in 26% of the incidents. Firefighters spent on average 4.8 minutes with the patient before handing over to paramedics; median 3.9 minutes, range of a few seconds to 39.2 minutes. Conclusion This study suggests that the MFESB EMR program is providing firefighter first responders to emergency situations in a short timeframe to assist the ambulance service. PMID:27147841

  2. Overview of the U.S. DOE Hydrogen Safety, Codes and Standards Program. Part 4: Hydrogen Sensors; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Buttner, William J.; Rivkin, Carl; Burgess, Robert; Brosha, Eric; Mukundan, Rangachary; James, C. Will; Keller, Jay

    2016-12-01

    Hydrogen sensors are recognized as a critical element in the safety design for any hydrogen system. In this role, sensors can perform several important functions including indication of unintended hydrogen releases, activation of mitigation strategies to preclude the development of dangerous situations, activation of alarm systems and communication to first responders, and to initiate system shutdown. The functionality of hydrogen sensors in this capacity is decoupled from the system being monitored, thereby providing an independent safety component that is not affected by the system itself. The importance of hydrogen sensors has been recognized by DOE and by the Fuel Cell Technologies Office's Safety and Codes Standards (SCS) program in particular, which has for several years supported hydrogen safety sensor research and development. The SCS hydrogen sensor programs are currently led by the National Renewable Energy Laboratory, Los Alamos National Laboratory, and Lawrence Livermore National Laboratory. The current SCS sensor program encompasses the full range of issues related to safety sensors, including development of advance sensor platforms with exemplary performance, development of sensor-related code and standards, outreach to stakeholders on the role sensors play in facilitating deployment, technology evaluation, and support on the proper selection and use of sensors.

  3. 基于MapGIS K9的基本农田监管系统的建设研究

    Institute of Scientific and Technical Information of China (English)

    覃艳琼; 覃豪杰

    2013-01-01

    基本农田数据库建设是保护耕地、实现基本农田规范亿管理的重要举措.本文以MapGIS K9地理信息套件为基础框架,介绍基本农田监管系统搭建方案,实现基本农田信息化动态管理,以全面提升基本农田保护水平.

  4. An Overview of the NASA Energy and Water cycle Study (NEWS) and the North American Water Program (NAWP)

    Science.gov (United States)

    Houser, P. R.

    2014-12-01

    NEWS: 10 years ago, NASA established the NASA Energy and Water-cycle Study (NEWS), whose long-term grand challenge is to document and enable improved, observationally based, predictions of water and energy cycle consequences of Earth system variability and change. The NEWS program builds upon existing NASA-supported basic research in atmospheric physics and dynamics, radiation, climate modeling, and terrestrial hydrology. While these NASA programs fund research activities that address individual aspects of the global energy and water cycles, they are not specifically designed to generate a coordinated result. NEWS developed the first coordinated attempt to describe the complete global energy and water cycle using existing and forthcoming satellite and ground based observations, and laying the foundation for essential NEWS developments in model representations of atmospheric energy and water exchange processes. This comprehensive energy and water data analysis program exploited crucial datasets, some requiring complete re-processing, and new satellite measurements. NAWP: Dramatically changing climates has had an indelible impact on North America's water crisis. To decisively address these challenges, we recommend that NAWP coalesce an interdisciplinary, international and interagency effort to make significant contributions to continental- to decision-scale hydroclimate science and solutions. By entraining, integrating and coordinating the vast array of interdisciplinary observational and prediction resources available, NAWP will significantly advance skill in predicting, assessing and managing variability and changes in North American water resources. We adopt three challenges to organize NAWP efforts. The first deals with developing a scientific basis and tools for mitigating and adapting to changes in the water supply-demand balance. The second challenge is benchmarking; to use incomplete and uncertain observations to assess water storage and quality dynamics, and

  5. Incorporating Cutting Edge Scientific Results from the MARGINS-GeoPRISMS Program into the Undergraduate Curriculum: An Overview

    Science.gov (United States)

    Morgan, J. K.; Costa, A.; Goodliffe, A. M.; Marshall, J. S.; Iverson, E. A. R.

    2014-12-01

    The NSF-MARGINS Program funded a decade of research on continental margin processes, organized around four initiatives: (1) chemical cycling in subduction zones (SubFac), (2) seismogenic zone processes at subduction zones (SEIZE), (3) rupturing continental lithosphere (RCL), and (4) source to sink sediment cycling at continental margins (S2S). The outcomes of this research provided critical new observations and insights into fundamental geologic processes along continental margins, and associated geologic hazards and economic resources. The transition to the successor GeoPRISMS Program provided a unique opportunity to identify and synthesize the highlights of MARGINS research, and to disseminate this knowledge to educators and students who will carry out the next phase of cutting-edge scientific research. The NSF TUES Program funded a two-year project entitled: "Bringing NSF MARGINS Continental Margins Research into the Undergraduate Curriculum," enabling development of ~15 mini-lessons drawing on key MARGINS results and data sets. The mini-lesson development team consists of 18 educators and scientists, grouped by initiative, and guided by experts in MARGINS science and current educational research and practices. Webinars and virtual check-ins enable team interactions and exchange of ideas and experiences; in person workshops solidified pedagogical approaches and assessment strategies, as well as initiative frameworks for the mini-lessons. Field testing by team members and outside volunteers during AY 2013-14 identified challenges and opportunities, guiding mini-lesson revision and finalization. The MARGINS mini-lessons define coordinated, data-rich educational resources, easy to access and free to the public, ready to be incorporated into multiple common geoscience course frameworks, taking the first step toward building a community of practice of scientists and curriculum specialists with the shared goal of moving cutting-edge science into undergraduate

  6. Overview of the 2003 and 2004 Field Program Phases of the Thunderstorm Electrification and Lightning Experiment (TELEX)

    Science.gov (United States)

    Rust, W. D.; Macgorman, D. R.; Schuur, T. J.; Bruning, E. C.; Weiss, S. A.; Straka, J.; Rison, W.; Hamlin, T.; Krehbiel, P. R.; Biggerstaff, M.; Apostololakopoulos, I.

    2004-12-01

    The scientific purpose of TELEX is to test and revise hypotheses concerning the inter-relationships among the wind field, microphysical characteristics, electrical structure, and lightning of isolated nonsevere and severe storms and mesoscale convective systems (MCSs). We conducted the field program of TELEX in central Oklahoma, 11 May-6 June 2003 and 9 May-20 June 2004. At the beginning of the 2003 field program, several new and upgraded observing systems were operating in central Oklahoma: the polarimetric part of the KOUN 11-cm wavelength Doppler radar, the Oklahoma three-dimensional Lightning Mapping Array (OK-LMA), and a mobile laboratory for storm intercept and mobile ballooning with up to four balloon soundings being possible simultaneously. Furthermore, the balloon-borne electric field meter was substantially upgraded the second year (both mechanically and electronically) to provide higher resolution data, including more accurate determination of instrument orientation to increase the resolution of three-dimensional electric field vectors in context of the three-dimensional structures of storm parameters and lightning. Presented in this paper are examples from both years in which instrumented balloons carrying a radiosonde and electric field meter obtained soundings. Other sensors were sometimes added to the instrument train by visiting researchers. In 2003, fourteen flights were made during seven missions. Owing to a scarcity of isolated deep convection in central Oklahoma during the 2003 program, the flights were mostly in nighttime multicellular storms and MCSs. In 2004, thirty-six flights were made during 13 ballooning missions. Soundings were made through nonsevere and severe storms and mesoscale convective systems. Several flights recorded data on both ascent and descent through the storm. Electric fields ranging above 150 kV/m were measured.

  7. Job-Oriented Basic Skills (JOBS) Curricula: An Overview of Four Research Studies to Improve Program Effectiveness.

    Science.gov (United States)

    1984-01-01

    sls learning by lower aptitude students. UNCLASSIFIED U cUYY wAIPcAT op ThNs PAom of 3mom*g FOREWORD This research was conducted under contract with...identify instructional methods, techniques, strategies, or content areas that could be used to improve JOBS program effectiveness. The contracting ...differential Is accounted for In part by the fact that 3OBS students have mucL lower aptitude scores and lower post-"A"-school-attrition rates than

  8. The first 7 years of the metropolitan fire brigade emergency responder program – an overview of incidents attended

    Directory of Open Access Journals (Sweden)

    Malcolm J Boyle

    2010-10-01

    Full Text Available Malcolm J Boyle1, Brett Williams1, Colin Bibby2, Allan Morton2, Chris Huggins11Department of Community Emergency Health and Paramedic Practice, Monash University, Frankston, Victoria, Australia; 2Emergency Medical Services, Metropolitan Fire and Emergency Services Board, Richmond, Victoria, AustraliaPurpose: The Melbourne Metropolitan Fire and Emergency Services Board (MFESB was the first fire service in Australia to implement a service-wide emergency medical response (EMR program in 2001. No additional scientific analysis of the first responder program has been reported since the pilot program. The objective of this study was to report the first 7 years of responses by firefighters as first responders.Patients and methods: The MFESB have three separate datasets with cardiac arrest information: (i callout record; (ii patient care record; and (iii cardiac arrest record, including data from the automatic external defibrillator. Descriptive statistics were used to summarize the demographic and specific outcome data. Ethics approval was granted.Results: A total of 8227 incidents were attended over the first 7 years. The most incidents attended were cardiac arrest 54% (n = 4450 followed by other medical 19% (n = 1579, and drug overdose 11% (n = 908; the remainder were <10% each. Sixty-three percent of incidents involved males. Average age was 57.2 years, median age 63 years, range from <1 month to 101 years; average response time was 6.1 minutes, median response time 5.6 minutes, range from 9 seconds to 31.5 minutes. Firefighters provided “initial care” in 57% and assisted in 26% of the incidents. Firefighters spent on average 4.8 minutes with the patient before handing over to paramedics; median 3.9 minutes, range of a few seconds to 39.2 minutes.Conclusion: This study suggests that the MFESB EMR program is providing firefighter first responders to emergency situations in a short timeframe to assist the ambulance service.Keywords: emergency

  9. Overview of the Year-One Field Program Phase of the Thunderstorm Electrification and Lightning Experiment (TELEX) 2003

    Science.gov (United States)

    Rust, D.; Macgorman, D.; Schuur, T.; Straka, J.; Rison, B.; Hamlin, T.; Krehbiel, P.; Bruning, E.

    2003-12-01

    Recent research has raised several issues that have significant implications for understanding storm electrification and lightning. The scientific purpose of TELEX is to test and revise hypotheses concerning the inter-relationships among the wind field, microphysical characteristics, electrical structure, and lightning of isolated severe storms and of large storm systems (called mesoscale convective systems, MCSs). We conducted the first-year's field program of TELEX in central Oklahoma, 11 May-6 June. This was the initial spring field deployment for several new observing systems operating in central Oklahoma: a 10-cm wavelength polarimetric Doppler radar, a lightning mapping array (LMA), and a new mobile lab for storm intercept and coordination of mobile ballooning of electric field meters and data acquisition. Also, the electric field meter was substantially upgraded (both mechanically and electronically) to provide higher resolution data, including more accurate determination of instrument orientation using a three-axis flux gate magnetometer arrangement and a two-axis accelerometer. The improvements allow more accurate determination of the electric field vector, and thus inferred charge structure, in context of the three-dimensional structures of storm parameters and lightning. Presented in this paper are examples from among the seven storm-intercept missions during which fourteen balloon soundings were obtained with instrumented balloons carrying a radiosonde and electric field meter. Owing to a scarcity of isolated deep convection in the target area during the program, the flights are mostly from nighttime multicellular storms and MCSs. Electric fields ranging above 100 kV/m were measured.

  10. Introductory Overviews

    NARCIS (Netherlands)

    Jakeman, A.J.; Hamilton, S.H.; Athanasiadis, I.N.; Pierce, S.A.

    2015-01-01

    Introductory Overview articles are designed to provide introductory level background to key themes and topics that caters to the eclectic readership of EMS. It is envisaged that these articles will help to break down barriers to shared understanding and dialogue within multidisciplinary teams, and m

  11. Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18.

    Science.gov (United States)

    Bao, Baolong; Pestinger, Valerie; Hassan, Yousef I; Borgstahl, Gloria E O; Kolar, Carol; Zempleni, Janos

    2011-05-01

    Holocarboxylase synthetase (HCS) mediates the binding of biotin to lysine (K) residues in histones H2A, H3 and H4; HCS knockdown disturbs gene regulation and decreases stress resistance and lifespan in eukaryotes. We tested the hypothesis that HCS interacts physically with histone H3 for subsequent biotinylation. Co-immunoprecipitation experiments were conducted and provided evidence that HCS co-localizes with histone H3 in human cells; physical interactions between HCS and H3 were confirmed using limited proteolysis assays. Yeast two-hybrid (Y2H) studies revealed that the N-terminal and C-terminal domains in HCS participate in H3 binding. Recombinant human HCS was produced and exhibited biological activity, as evidenced by biotinylation of its known substrate, recombinant p67. Recombinant histone H3.2 and synthetic H3-based peptides were also good targets for biotinylation by recombinant HCS (rHCS) in vitro, based on tracing histone-bound biotin with [(3)H]biotin, streptavidin and anti-biotin antibody. Biotinylation site-specific antibodies were generated and revealed that both K9 and K18 in H3 were biotinylated by HCS. Collectively, these studies provide conclusive evidence that HCS interacts directly with histone H3, causing biotinylation of K9 and K18. We speculate that the targeting of HCS to distinct regions in human chromatin is mediated by DNA sequence, biotin, RNA, epigenetic marks or chromatin proteins.

  12. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis.

    Science.gov (United States)

    Lee, Jayhun; Kang, Sangjo; Lilja, Karin C; Colletier, Keegan J; Scheitz, Cornelia Johanna Franziska; Zhang, Ying V; Tumbar, Tudorita

    2016-04-15

    Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. Skin hypomethylation during quiescence was necessary for subsequent progression of hair homeostasis (cycle). Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation in vivo during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis.

  13. Mission Operations Directorate - Success Legacy of the Space Shuttle Program (Overview of the Evolution and Success Stories from MOD During the Space Shuttle program)

    Science.gov (United States)

    Azbell, Jim A.

    2011-01-01

    In support of the Space Shuttle Program, as well as NASA's other human space flight programs, the Mission Operations Directorate (MOD) at the Johnson Space Center has become the world leader in human spaceflight operations. From the earliest programs - Mercury, Gemini, Apollo - through Skylab, Shuttle, ISS, and our Exploration initiatives, MOD and its predecessors have pioneered ops concepts and emphasized a history of mission leadership which has added value, maximized mission success, and built on continual improvement of the capabilities to become more efficient and effective. This paper provides specific examples that illustrate how MOD's focus on building and contributing value with diverse teams has been key to their successes both with the US space industry and the broader international community. This paper will discuss specific examples for the Plan, Train, Fly, and Facilities aspects within MOD. This paper also provides a discussion of the joint civil servant/contractor environment and the relative badge-less society within MOD. Several Shuttle mission related examples have also been included that encompass all of the aforementioned MOD elements and attributes, and are used to show significant MOD successes within the Shuttle Program. These examples include the STS-49 Intelsat recovery and repair, the (post-Columbia accident) TPS inspection process and the associated R-Bar Pitch Maneuver for ISS missions, and the STS-400 rescue mission preparation efforts for the Hubble Space Telescope repair mission. Since their beginning, MOD has consistently demonstrated their ability to evolve and respond to an ever changing environment, effectively prepare for the expected and successfully respond to the unexpected, and develop leaders, expertise, and a culture that has led to mission and Program success.

  14. Stress relaxation damage in K9 glass plate irradiated by 1.06μm CW laser%1.06μm连续激光照射下K9玻璃板的应力松驰破坏

    Institute of Scientific and Technical Information of China (English)

    罗福; 孙承纬; 杜祥琬

    2001-01-01

    Based on the stress relaxation model in 1D planar geometry andthe visco-elastic constitutive equation, the temperature and stress histories in the K9 glass samples irradiated by CW laser beams (λ=1.06μm) have been calculated. The results indicate that the residual tensile stress due to the stress relaxation effect during cooling after the laser radiation may be greater than the tensile fracture strength of samples, while the maximum compression stress during the laser heating is less than the requirement for compression damage. For a K9 glass window of 3mm thickness, its damage due to the stress relaxation may be induced by a laser radiation of 0.946MW/cm2 for 0.2s. Therefore, the stress relaxation should be regarded as the main mechanism of damage in K9 glass windows while a CW laser beam (λ=1.06μm) irradiates it with large spot.%基于一维应力松弛模型和粘弹性本构关系,对1.06μm连续激光照射下K9玻璃板中的温升和应力作了计算,结果表明,由于应力松弛效应,激光停照后的冷却过程中产生的残余拉伸应力可达到玻璃的拉伸断裂强度阈值,而激光加热期间的最大压缩应力却小于压缩断裂强度要求。对3mm厚的K9玻璃板,由应力松弛引起破坏所要求的激光参数为946kWcm2作用0.2s,因而应力松弛可能为1.06μm连续激光大光斑照射下K9玻璃窗口损伤的主要模式。

  15. South Atlantic Margin Processes and Links with Onshore Evolution: Overview of the German Priority Program SAMPLE (Invited)

    Science.gov (United States)

    Trumbull, R. B.

    2013-12-01

    Since 2009 the SAMPLE program (www.spp-sample.de) provides a platform for research into the causes and effects of continental breakup and the evolution of passive margins. SAMPLE encompasses 28 projects from 13 German institutions and many international partnerships. The 6-year program will run through 2015. At the core of the program are observational studies that are interlinked by modelling projects examining the interplay of deep mantle dynamics, lithospheric stress fields, pre-rift fabric and melt-weaking on localizing rifting. Geophysics teams collect and integrate existing data from wide-angle seismic profiles, reprocessed multichannel seismics, as well as gravity, magnetics and heat-flow studies to construct self-consistent lithospheric-scale 3-D models along the conjugate margins. Key interests are variations in margin architecture, distribution of magmatic features and the evolution of sedimentary basins (subsidence and thermal histories). An exciting new contribution of SAMPLE geophysics is a linked set of seismic, seismologic and magnetotelluric experiments along the Walvis Ridge, including onshore NW Namibia and the Tristan da Cunha hotspot. In the deep mantle, we examine evidence from global seismic tomography for dramatic low seismic-velocity regions near the core-mantle boundary beneath southern Africa and their implications for dynamics in the deep Earth and the thermo-chemical nature of plumes. Petrologic studies focus on near-primary mantle melts represented by Mg-rich mafic dikes. Projects address the origin of magmas and crust-mantle interaction, and the environmental impact of mega-scale volcanism during breakup. Thermobarometry results from the African margin reveal a N-to-S decrease in mantle potential temperatures from 1520°C (N) to 1380° (S), which supports a thermal plume origin for excessive melt production in the north. Thermochronology data from both conjugate margins reveal complex and puzzling patterns in the denudation history

  16. K9A1 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  17. K9D7 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  18. K9L2 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  19. State Estimation for K9

    Science.gov (United States)

    Xu, Ru-Gang; Koga, Dennis (Technical Monitor)

    2001-01-01

    The goal of 'Estimate' is to take advantage of attitude information to produce better pose while staying flexible and robust. Currently there are several instruments that are used for attitude: gyros, inclinometers, and compasses. However, precise and useful attitude information cannot come from one instrument. Integration of rotational rates, from gyro data for example, would result in drift. Therefore, although gyros are accurate in the short-term, accuracy in the long term is unlikely. Using absolute instruments such as compasses and inclinometers can result in an accurate measurement of attitude in the long term. However, in the short term, the physical nature of compasses and inclinometers, and the dynamic nature of a mobile platform result in highly volatile and therefore useless data. The solution then is to use both absolute and relative data. Kalman Filtering is known to be able to combine gyro and compass/inclinometer data to produce stable and accurate attitude information. Since the model of motion is linear and the data comes in as discrete samples, a Discrete Kalman Filter was selected as the core of the new estimator. Therefore, 'Estimate' can be divided into two parts: the Discrete Kalman Filter and the code framework.

  20. K9S2 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  1. K9V6 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  2. Overview of the program to assess the reliability of emerging nondestructive techniques open testing and study of flaw type effect on NDE response

    Science.gov (United States)

    Meyer, Ryan M.; Komura, Ichiro; Kim, Kyung-cho; Zetterwall, Tommy; Cumblidge, Stephen E.; Prokofiev, Iouri

    2016-02-01

    In February 2012, the U.S. Nuclear Regulatory Commission (NRC) executed agreements with VTT Technical Research Centre of Finland, Nuclear Regulatory Authority of Japan (NRA, former JNES), Korea Institute of Nuclear Safety (KINS), Swedish Radiation Safety Authority (SSM), and Swiss Federal Nuclear Safety Inspectorate (ENSI) to establish the Program to Assess the Reliability of Emerging Nondestructive Techniques (PARENT). The goal of PARENT is to investigate the effectiveness of current emerging and perspective novel nondestructive examination procedures and techniques to find flaws in nickel-alloy welds and base materials. This is done by conducting a series of open and blind international round-robin tests on a set of large-bore dissimilar metal welds (LBDMW), small-bore dissimilar metal welds (SBDMW), and bottom-mounted instrumentation (BMI) penetration weld test blocks. The purpose of blind testing is to study the reliability of more established techniques and included only qualified teams and procedures. The purpose of open testing is aimed at a more basic capability assessment of emerging and novel technologies. The range of techniques applied in open testing varied with respect to maturity and performance uncertainty and were applied to a variety of simulated flaws. This paper will include a brief overview of the PARENT blind and open testing techniques and test blocks and present some of the blind testing results.

  3. US Army TARDEC: Robotics Overview

    Science.gov (United States)

    2010-03-25

    unclassified US ARMY TARDEC Robotics Overview Bernard Theisen, Joint Center for Robotics 25 March 2010 Reference herein to any specific commercial...4. TITLE AND SUBTITLE US ARMY TARDEC Robotics Overview 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Bernard... Robotics Industry Partnerships Academia PartnershipsGovernment Partnerships TRADOC Community Outreach • S&T Support to the RS-JPO • Develops and Fosters

  4. HYPERFINE STRUCTURE SPECTRA FOR 4f45d6K\\-9/2→(23229.991)o\\-9/2 TRANSITION IN 143,145Nd+%143,145Nd+ 4f45d6K\\-9/2→(23229.991)o\\-9/2 跃迁超精细结构光谱

    Institute of Scientific and Technical Information of China (English)

    马洪良; 陆福全

    2001-01-01

    利用共线快离子束-激光光谱学方法测量了143,145Nd+ 6K\\-9/2→(23229.991)o\\-9/2跃迁的超精细结构光谱,得到了上、下能级的超精细相互作用常数.%Hyperfine structure spectra for 4f45d 6K\\-9/2→(23229.991)o\\-9/2 transition in 143,145Nd+ were measured by using collinear fast-ion-beam laser spectroscopy, and the magnetic dipole and electric quadrupole coupling constants of the metastable levels and excited levels were determined.

  5. MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9.

    Science.gov (United States)

    Nie, Fang; Liu, Tianming; Zhong, Liang; Yang, Xianggui; Liu, Yunhong; Xia, Hongwei; Liu, Xiaoqiang; Wang, Xiaoyan; Liu, Zhicheng; Zhou, Li; Mao, Zhaomin; Zhou, Qin; Chen, Tingmei

    2016-01-01

    Increasing evidence revealed that miRNAs, the vital regulators of gene expression, are involved in various cellular processes, including cell growth, differentiation, apoptosis and progression. In addition, miRNAs act as oncogenes and/or tumor suppressors. The present study aimed to verify the potential roles of miR148b in human renal cancer cells. miR‑148b was found to be downregulated in human renal cancel tissues and human renal cancer cell lines. Functional studies demonstrated that plasmid‑mediated overexpression of miR‑148b promoted cell proliferation, increased the S‑phase population of the cell cycle and enhanced apoptosis in the 786‑O and OS‑RC‑2 renal cancer cell lines, while it did not appear to affect the total number of viable cells according to a Cell Counting Kit‑8 assay. Subsequently, a luciferase reporter assay verified that miR148b directly targeted mitogen‑activated protein kinase (MAPK) kinase kinase 9 (MAP3K9), an upstream activator of MAPK kinase/c‑Jun N‑terminal kinase (JNK) signaling, suppressing the protein but not the mRNA levels. Furthermore, western blot analysis indicated that overexpression of miR148b in renal cancer cells inhibited MAPK/JNK signaling by decreasing the expression of phosphorylated (p)JNK. In addition, overexpression of MAP3K9 and pJNK was detected in clinical renal cell carcinoma specimens compared with that in their normal adjacent tissues. The present study therefore suggested that miR‑148b exerts an oncogenic function by enhancing the proliferation and apoptosis of renal cancer cells by inhibiting the MAPK/JNK pathway.

  6. Chromosomal distribution of H3K4me2, H3K9me2 and 5-methylcytosine: variations associated with polyploidy and hybridization in Brachiaria (Poaceae).

    Science.gov (United States)

    de Paula, Cristina Maria Pinto; Souza Sobrinho, Fausto; Techio, Vânia Helena

    2016-06-01

    Assessment of chromosomal distribution of modified histones and 5-methylcytosine shown that there are diversification of chromosomal types among species of Brachiaria and its interspecific hybrids. Histone post-translational modifications and DNA methylation are epigenetic processes that are involved in structural and functional organization of the genome. This study compared the chromosomal distribution of modified histones and 5-methylcytosine (5-mCyt) in species and interspecific hybrids of Brachiaria with different ploidy levels and reproduction modes. The relation between H3K9me2 and 5-mCyt was observed in the nucleolus organizer region, centromeric central domain and pericentromeric region. H3K4me2 was detected in euchromatic domains, mainly in the terminal chromosomal regions. Comparison of chromosomal distribution among species and hybrids showed greater variation of chromosomal types for the H3K9me2 in B. decumbens (tetraploid and apomictic species) and the 963 hybrid, while, for the H3K4me2, the variation was higher in B. brizantha and B. decumbens (tetraploid and apomictic species) and 963 hybrid. The chromosome distribution of 5-mCyt was similar between B. brizantha and B. decumbens, which differ from the distribution observed in B. ruziziensis (diploid and sexual species). Significant alterations in DNA methylation were observed in the artificially tetraploidized B. ruziziensis and in the interspecific hybrids, possibly as result of hybridization and polyploidization processes. The monitoring of histone modifications and DNA methylation allowed categorizing nuclear and chromosomal distribution of these epigenetic marks, thus contributing to the knowledge of composition and structure of the genome/epigenome of Brachiaria species and hybrids. These data can be useful for speciation and genome evolution studies in genus Brachiaria, and represent important markers to explore relationships between genomes.

  7. Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.

    Science.gov (United States)

    Schotta, Gunnar; Ebert, Anja; Krauss, Veiko; Fischer, Andreas; Hoffmann, Jan; Rea, Stephen; Jenuwein, Thomas; Dorn, Rainer; Reuter, Gunter

    2002-03-01

    Su(var)3-9 is a dominant modifier of heterochromatin-induced gene silencing. Like its mammalian and Schizosaccharomyces pombe homologues, Su(var) 3-9 encodes a histone methyltransferase (HMTase), which selectively methylates histone H3 at lysine 9 (H3-K9). In Su(var)3-9 null mutants, H3-K9 methylation at chromocentre heterochromatin is strongly reduced, indicating that SU(VAR)3-9 is the major heterochromatin-specific HMTase in Drosophila. SU (VAR)3-9 interacts with the heterochromatin-associated HP1 protein and with another silencing factor, SU(VAR)3-7. Notably, SU(VAR)3-9-HP1 interaction is interdependent and governs distinct localization patterns of both proteins. In Su(var)3-9 null mutants, concentration of HP1 at the chromocentre is nearly lost without affecting HP1 accumulation at the fourth chromosome. By contrast, in HP1 null mutants SU(VAR)3-9 is no longer restricted at heterochromatin but broadly dispersed across the chromosomes. Despite this interdependence, Su(var)3-9 dominates the PEV modifier effects of HP1 and Su(var)3-7 and is also epistatic to the Y chromosome effect on PEV. Finally, the human SUV39H1 gene is able to partially rescue Su(var)3-9 silencing defects. Together, these data indicate a central role for the SU(VAR)3-9 HMTase in heterochromatin-induced gene silencing in Drosophila.

  8. Effect of sleep deprivation on H3K9 and H3K4 methylation in the different brain region of rats%REM期睡眠剥夺对大鼠不同脑区组蛋白H3K9和H3K4甲基化水平的影响

    Institute of Scientific and Technical Information of China (English)

    马安东; 马妮; 史明; 田丰仓; 吴中亮

    2016-01-01

    目的:研究REM期睡眠剥夺对成年大鼠不同脑区包括海马、腹内侧前额叶皮质、下丘脑和中缝核群的组蛋白H3K9和H3K4三甲基化水平的影响.方法:将成年SD大鼠随机分为正常对照组(con)、睡眠剥夺1d组(SD1 d)、睡眠剥夺3d组(SD3 d)、睡眠剥夺6d组(SD6 d).采用改良式多平台水环境法建立REM期睡眠剥夺模型,分别于睡眠剥夺后1、3、6d断头取脑,用免疫荧光染色与Western Blot检测大鼠海马、腹内侧前额叶皮质、下丘脑和中缝核群H3K9和H3K4三甲基化水平的变化,最终结果进行统计学分析.结果:Western Blot结果显示:(1)海马、腹内侧前额叶皮质三个SD组H3K9三甲基化水平均低于control组(P<0.05),H3K4三甲基化水平均高于control组(P<0.05);(2)下丘脑三个SD组H3K9三甲基化水平均低于control组(P<0.01),但SD1 d组H3K4三甲基化水平高于control组(P<0.05),SD3 d、SD6 d组H3K4三甲基化水平低于control组(P<0.05);(3)中缝核群三个SD组H3K9和H3K4三甲基化水平均高于control组(P<0.05).对海马与下丘脑免疫荧光验证H3K9三甲基化结果与Western Blot结果趋势一致,且说明细胞无减少.结论:睡眠剥夺可能与海马、腹内侧前额叶皮质、下丘脑和中缝核群的组蛋白H3K9和H3K4三甲基化水平密切相关.

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection ... and Awards Overview Scholarships, Fellowships, and Awards Overview Health Policy Scholarships Scholarships for International Surgeons Research Scholarships ...

  10. Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Dongmei eTang

    2016-05-01

    Full Text Available The activation of neuromast supporting cell (SC proliferation leads to hair cell (HC regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of H3K9me2 in HC regeneration after HC loss remains poorly understood. In this study, we focused on the role of H3K9me2 in HC regeneration following neomycin-induced HC loss. To investigate the effects of H3K9me2 in HC regeneration, we took advantage of the G9a/GLP-specific inhibitor BIX01294 that significantly reduces the dimethylation of H3K9. We found that BIX01294 significantly reduced HC regeneration after neomycin-induced HC loss in the zebrafish lateral line. BIX01294 also significantly reduced the proliferation of neuromast cells and led to fewer SCs in the lateral line. In situ hybridization showed that BIX01294 significantly down-regulated the Wnt and Fgf signaling pathways, which resulted in reduced SC proliferation and HC regeneration in the neuromasts of the lateral line. Altogether, our results suggest that down-regulation of H3K9me2 significantly decreases HC regeneration after neomycin-induced HC loss through inactivation of the Wnt/β-catenin and Fgf signaling pathways. Thus H3K9me2 plays a critical role in HC regeneration.

  11. Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways

    Science.gov (United States)

    Tang, Dongmei; Lin, Qin; He, Yingzi; Chai, Renjie; Li, Huawei

    2016-01-01

    The activation of neuromast (NM) supporting cell (SC) proliferation leads to hair cell (HC) regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of H3K9me2 in HC regeneration after HC loss remains poorly understood. In this study, we focused on the role of H3K9me2 in HC regeneration following neomycin-induced HC loss. To investigate the effects of H3K9me2 in HC regeneration, we took advantage of the G9a/GLP-specific inhibitor BIX01294 that significantly reduces the dimethylation of H3K9. We found that BIX01294 significantly reduced HC regeneration after neomycin-induced HC loss in the zebrafish lateral line. BIX01294 also significantly reduced the proliferation of NM cells and led to fewer SCs in the lateral line. In situ hybridization showed that BIX01294 significantly down-regulated the Wnt and Fgf signaling pathways, which resulted in reduced SC proliferation and HC regeneration in the NMs of the lateral line. Altogether, our results suggest that down-regulation of H3K9me2 significantly decreases HC regeneration after neomycin-induced HC loss through inactivation of the Wnt/β-catenin and Fgf signaling pathways. Thus H3K9me2 plays a critical role in HC regeneration. PMID:27303264

  12. The USAF STINFO Program Overview

    Science.gov (United States)

    1989-06-01

    For N’IT T I S J ),.-t lf•i cation U ’Dstri:’... Ion/ A :.’ja I tY Codes ii r 2/or IDist SpOc al I/ - I 4318 essend noSteN INFO/tek 4318...accessible online as part I of the DROLS system. " STINFO responsibilities concerning Work Units are: m " Ensure that the R&T WUIS database is searched...System Database" i 5. DLAM 4185.18, "Defense RDT&E Online System, Dial-Up Retrieval Self-Training Manual" I I I I ’I I l I I I I USAF STINFO Ovwrview

  13. Overview of the COMPETE Program

    CERN Document Server

    Ezhela, Vladimir V; Gauron, P; Kang, K; Kang, S K; Kuyanov, Y V; Lengyel, A I; Lugovsky, K S; Lugovsky, S B; Lugovsky, V S; Martynov, E S; Nicolescu, Basarab; Razuvaev, E A; Sapunov, M Y; Selyugin, O V; Tkachenko, N P; Whalley, M R; Zenin, O V; Kuyanov, Yu.V.

    2002-01-01

    Nowadays, scientific databases have become the bread-and-butter of particle physicists. These databases must be maintained and checked repeatedly to insure the accuracy of their content. The COMPETE collaboration aims at motivating data maintenance via the interfacing of theory and experiment at the database level. The database concept then needs to be supplemented by a "model-base". Such an object enables one not only to decide what the best description may be, but also to discern what potential problems exist in the data. The systematization of such a cross-fertilization between models and data results in the "object of knowledge" that is the point at which all existing information resources on a given problem could converge. There are many advantages to such a global approach. First of all, the maintenance of a data set is not a static task: it needs to be motivated by physics. The second advantage is that one can have a common testing ground for theories and models. Thirdly, an extensive theoretical datab...

  14. GSBPP Overview

    OpenAIRE

    2007-01-01

    The Graduate School of Business & Public Policy is responsible for academic programs designed to educate officers and DoD civilian employees in a variety of functional management specialties. About 250 resident students are enrolled in various Master's degree curricula at any point in time. The school offers resident graduate programs and non-resident graduate programs using on-site instructions or latest VTE technology.

  15. Digital electronic engine control F-15 overview

    Science.gov (United States)

    Kock, B.

    1984-01-01

    A flight test evaluation of the digital elctronic engine control (DEEC) system was conducted. An overview of the flight program is presented. The roles of the participating parties, the system, and the flight program objectives are described. The test program approach is discussed, and the engine performance benefits are summarized. A description of the follow-on programs is included.

  16. Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts.

    Science.gov (United States)

    Peng, Chang; Zhang, Weihua; Zhao, Weian; Zhu, Jing; Huang, Xupei; Tian, Jie

    2015-06-01

    The expression of cardiac genes is precisely regulated, and any perturbation may cause developmental defects. In a previous study, we demonstrated that alcohol consumption during pregnancy could lead to uncontrolled expressions of cardiac genes and eventually result in cardiac dysplasia. However, the underlying mechanisms remain unclear. In the present study, we have investigated the alcohol-induced cardiac hypertrophy and its potential mechanisms. Furthermore, the protective effect of anacardic acid against the alcohol-induced cardiac hypertrophy has been explored in experimental mice. C57BL/6 pregnant mice were gavaged with 56% ethanol or saline and the hearts of their fetus were collected for analysis. Binding of p300, CBP, PCAF, SRC1, except GCN5, were increased to the NKX2.5 promoter in fetal mouse hearts exposed to alcohol. Increased acetylation of H3K9 and increased mRNA expression of NKX2.5, β-MHC and Cx43 were observed in the same samples. Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 and PCAF to the NKX2.5, β-MHC, Cx43 promoters and attenuated H3K9 hyperacetylation. Interestingly, anacardic acid down-regulated over-expression of these cardiac genes induced by alcohol and ultimately attenuated ethanol-induced cardiac hypertrophy in fetal mice. Our results indicate that alcohol exposure during pregnancy could lead to fetal cardiac hypertrophy. The over-expression of NKX2.5, β-MHC, Cx43 mediated by p300 and PCAF may be critical mechanisms of alcohol-induced cardiac hypertrophy. Anacardic acid can down-regulate the over-expression of cardiac genes and reverse cardiac hypertrophy caused by alcohol treatment in pregnant mice, suggesting it could be a potential therapeutic agent for the treatment of cardiac hypertrophy. Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  17. IBL Overview

    CERN Document Server

    Ferrere, D; The ATLAS collaboration

    2014-01-01

    The ATLAS IBL project is reaching a completion phase with the integration of the staves around the IPT and beam pipe structure. The installation and insertion into the Pixel will be done in May with a tight schedule constraint. This talk will give an overview of the project including the production status and the recent issues met like the corrosion problem. The tremendous effort made to recover the production and optimize the time and the available components to test the full on-detector and off-detector chain highlighted very efficient and excellent results. The integration tools and all the engineering efforts are also made to ensure the success of the last operations on the surface and in the cavern.

  18. MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

    Science.gov (United States)

    Thambirajah, Anita A.; Ng, Marlee K.; Frehlick, Lindsay J.; Li, Andra; Serpa, Jason J.; Petrotchenko, Evgeniy V.; Silva-Moreno, Begonia; Missiaen, Kristal K.; Borchers, Christoph H.; Adam Hall, J.; Mackie, Ryan; Lutz, Frank; Gowen, Brent E.; Hendzel, Michael; Georgel, Philippe T.; Ausió, Juan

    2012-01-01

    Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-binding protein that mediates transcriptional regulation, and is highly abundant in brain. The nature of its binding to reconstituted templates has been well characterized in vitro. However, its interactions with native chromatin are less understood. Here we show that MeCP2 displays a distinct distribution within fractionated chromatin from various tissues and cell types. Artificially induced global changes in DNA methylation by 3-aminobenzamide or 5-aza-2′-deoxycytidine, do not significantly affect the distribution or amount of MeCP2 in HeLa S3 or 3T3 cells. Most MeCP2 in brain is chromatin-bound and localized within highly nuclease-accessible regions. We also show that, while in most tissues and cell lines, MeCP2 forms stable complexes with nucleosome, in brain, a fraction of it is loosely bound to chromatin, likely to nucleosome-depleted regions. Finally, we provide evidence for novel associations of MeCP2 with mononucleosomes containing histone H2A.X, H3K9me2 and H3K27me3 in different chromatin fractions from brain cortex and in vitro. We postulate that the functional compartmentalization and tissue-specific distribution of MeCP2 within different chromatin types may be directed by its association with nucleosomes containing specific histone variants, and post-translational modifications. PMID:22144686

  19. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.

    Science.gov (United States)

    Fawdar, Shameem; Trotter, Eleanor W; Li, Yaoyong; Stephenson, Natalie L; Hanke, Franziska; Marusiak, Anna A; Edwards, Zoe C; Ientile, Sara; Waszkowycz, Bohdan; Miller, Crispin J; Brognard, John

    2013-07-23

    Approximately 70% of patients with non-small-cell lung cancer present with late-stage disease and have limited treatment options, so there is a pressing need to develop efficacious targeted therapies for these patients. This remains a major challenge as the underlying genetic causes of ~50% of non-small-cell lung cancers remain unknown. Here we demonstrate that a targeted genetic dependency screen is an efficient approach to identify somatic cancer alterations that are functionally important. By using this approach, we have identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. Mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases inhibits proliferation, suppresses constitutive activation of downstream signaling pathways, and results in specific killing of the lung cancer cells. Genomic profiling of patients with lung cancer is ushering in an era of personalized medicine; however, lack of actionable mutations presents a significant hurdle. Our study indicates that targeted genetic dependency screens will be an effective strategy to elucidate somatic variants that are essential for lung cancer cell viability.

  20. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia.

    Directory of Open Access Journals (Sweden)

    Pavel Burda

    Full Text Available GATA-1 and PU.1 are two important hematopoietic transcription factors that mutually inhibit each other in progenitor cells to guide entrance into the erythroid or myeloid lineage, respectively. PU.1 controls its own expression during myelopoiesis by binding to the distal URE enhancer, whose deletion leads to acute myeloid leukemia (AML. We herein present evidence that GATA-1 binds to the PU.1 gene and inhibits its expression in human AML-erythroleukemias (EL. Furthermore, GATA-1 together with DNA methyl Transferase I (DNMT1 mediate repression of the PU.1 gene through the URE. Repression of the PU.1 gene involves both DNA methylation at the URE and its histone H3 lysine-K9 methylation and deacetylation as well as the H3K27 methylation at additional DNA elements and the promoter. The GATA-1-mediated inhibition of PU.1 gene transcription in human AML-EL mediated through the URE represents important mechanism that contributes to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy.

  1. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia.

    Science.gov (United States)

    Burda, Pavel; Vargova, Jarmila; Curik, Nikola; Salek, Cyril; Papadopoulos, Giorgio Lucio; Strouboulis, John; Stopka, Tomas

    2016-01-01

    GATA-1 and PU.1 are two important hematopoietic transcription factors that mutually inhibit each other in progenitor cells to guide entrance into the erythroid or myeloid lineage, respectively. PU.1 controls its own expression during myelopoiesis by binding to the distal URE enhancer, whose deletion leads to acute myeloid leukemia (AML). We herein present evidence that GATA-1 binds to the PU.1 gene and inhibits its expression in human AML-erythroleukemias (EL). Furthermore, GATA-1 together with DNA methyl Transferase I (DNMT1) mediate repression of the PU.1 gene through the URE. Repression of the PU.1 gene involves both DNA methylation at the URE and its histone H3 lysine-K9 methylation and deacetylation as well as the H3K27 methylation at additional DNA elements and the promoter. The GATA-1-mediated inhibition of PU.1 gene transcription in human AML-EL mediated through the URE represents important mechanism that contributes to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy.

  2. piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.

    Science.gov (United States)

    Pezic, Dubravka; Manakov, Sergei A; Sachidanandam, Ravi; Aravin, Alexei A

    2014-07-01

    Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a diverse set of TEs in germ cells. In mice, piRNA-guided transposon repression correlates with establishment of CpG DNA methylation on their sequences, yet the mechanism and the spectrum of genomic targets of piRNA silencing are unknown. Here we show that in addition to DNA methylation, the piRNA pathway is required to maintain a high level of the repressive H3K9me3 histone modification on long interspersed nuclear elements (LINEs) in germ cells. piRNA-dependent chromatin repression targets exclusively full-length elements of actively transposing LINE families, demonstrating the remarkable ability of the piRNA pathway to recognize active elements among the large number of genomic transposon fragments.

  3. Loss of the DNA methyltransferase MET1 Induces H3K9 hypermethylation at PcG target genes and redistribution of H3K27 trimethylation to transposons in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Angelique Deleris

    Full Text Available Dimethylation of histone H3 lysine 9 (H3K9m2 and trimethylation of histone H3 lysine 27 (H3K27m3 are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG proteins and is associated with silent protein-coding genes, while H3K9m2 is correlated with DNA methylation and is associated with transposons and repetitive sequences. Recently, ectopic genic DNA methylation in the CHG context (where H is any base except G has been observed in globally DNA hypomethylated mutants such as met1, but neither the nature of the hypermethylated loci nor the biological significance of this epigenetic phenomenon have been investigated. Here, we generated high-resolution, genome-wide maps of both H3K9m2 and H3K27m3 in wild-type and met1 plants, which we integrated with transcriptional data, to explore the relationships between these two marks. We found that ectopic H3K9m2 observed in met1 can be due to defects in IBM1-mediated H3K9m2 demethylation at some sites, but most importantly targets H3K27m3-marked genes, suggesting an interplay between these two silencing marks. Furthermore, H3K9m2/DNA-hypermethylation at these PcG targets in met1 is coupled with a decrease in H3K27m3 marks, whereas CG/H3K9m2 hypomethylated transposons become ectopically H3K27m3 hypermethylated. Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation but ectopic hypermethylation of genes previously marked by H3K27m3.

  4. Rhinitis Overview

    Science.gov (United States)

    ... Education Center Fellows-in-Training Grants & Awards Program Directors Practice Resources ASTHMA IQ Consultation and Referral Guidelines Practice Financial Survey Practice Tools Running a Practice Statements and Practice Parameters About AAAAI Advocacy Allergist / Immunologists: ...

  5. SEI Overview

    Science.gov (United States)

    2012-06-11

    Architecting • Edge Programming for Mobile Platforms • Software Assurance Argumentation Theories • Secure Coding Patterns for C, C++, and Java...ACE/TSP Software Assurance Cases SOA Certification Program V&B Documentation SMART Malware & Forensics Analysis for Mobile Platforms XNET 14...Technology Specific Training • IPv6 • Wireless Security • SiLK & Netflow Analysis 75 The Cyber Exercise Challenge How to make cyber exercises

  6. An Overview. High Risk Series.

    Science.gov (United States)

    General Accounting Office, Washington, DC.

    This report provides an overview of efforts undertaken by the U.S. General Accounting Office (GAO) in 1990 to review and report on federal program areas its work identified as high risk because of vulnerabilities to waste, fraud, abuse, and mismanagement. It reviews the current status of efforts to address these concerns. The six categories of…

  7. Radiation Detection Overview for Nuclear Emergency Response

    Energy Technology Data Exchange (ETDEWEB)

    Myers, Steven Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-11-16

    This presentation discusses the fundamentals of gamma and neutron detection; presents an overview of the DOE Triage and JTOT Programs, gamma, and neutron signatures in select measurements; and offers a detector demonstration.

  8. Identification and characterization of the Spodoptera Su(var 3-9 histone H3K9 trimethyltransferase and its effect in AcMNPV infection.

    Directory of Open Access Journals (Sweden)

    Binbin Li

    Full Text Available Histone H3-lysine(9 (H3K9 trimethyltransferase gene Su(var 3-9 was cloned and identified in three Spodoptera insects, Spodopterafrugiperda (S. frugiperda, S. exigua and S. litura. Sequence analysis showed that Spodoptera Su(var 3-9 is highly conserved evolutionarily. Su(var 3-9 protein was found to be localized in the nucleus in Sf9 cells, and interact with histone H3, and the heterochromatin protein 1a (HP1a and HP1b. A dose-dependent enzymatic activity was found at both 27 °C and 37 °C in vitro, with higher activity at 27 °C. Addition of specific inhibitor chaetocin resulted in decreased histone methylation level and host chromatin relaxation. In contrast, overexpression of Su(var 3-9 caused increased histone methylation level and cellular genome compaction. In AcMNV-infected Sf9 cells, the transcription of Su(var 3-9 increased at late time of infection, although the mRNA levels of most cellular genes decreased. Pre-treatment of Sf9 cells with chaetocin speeded up viral DNA replication, and increased the transcription level of a variety of virus genes, whereas in Sf9 cells pre-transformed with Su(var 3-9 expression vector, viral DNA replication slow down slightly. These findings suggest that Su(var 3-9 might participate in the viral genes expression an genome replication repression during AcMNPV infection. It provided a new insight for the understanding virus-host interaction mechanism.

  9. 45 CFR 2554.1 - Overview of regulations.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Overview of regulations. 2554.1 Section 2554.1... SERVICE PROGRAM FRAUD CIVIL REMEDIES ACT REGULATIONS Overview and Definitions § 2554.1 Overview of... claim, regardless of whether property, services, or money is actually delivered or paid by...

  10. SIM.T-K9.1: Canada/Peru bilateral comparison of standard platinum resistance thermometers from 0.01 °C to 419.527 °C

    Science.gov (United States)

    Hill, K. D.; Barrientos, A.; Guillen, E.

    2015-01-01

    The Consultative Committee for Thermometry has organized Key Comparison 9 (CCT-K9) as an updated replacement for CCT-K3. A comparison of the fixed-point temperature standards of Peru with those of Canada was carried out following a protocol that closely resembles CCT-K9. The comparison was limited to the fixed points of tin and zinc, with NRC the pilot laboratory and the eventual link to CCT-K9 (currently, CCT-K9 remains a work in progress). The comparison protocol required INDECOPI to select, characterize, and transport (i.e. hand carry) the SPRTs to NRC. Following the measurements at NRC, the SPRTs were returned and re-measured at INDECOPI to close the loop and assess any changes that occurred in the SPRTs over the course of the measurements. The following degrees of equivalence, D, and expanded uncertainties, U (k = 2), were obtained via this comparison. T / °C DINDECOPI / mK U / mK 419.527 1.58 4.6 231.928 -2.12 3.9 SIM.T-K9.1 has demonstrated the compatibility of the fixed points of INDECOPI with those maintained by NRC within the combined uncertainties, and therefore serves to verify the intended calibration and measurement capabilities envisioned for INDECOPI, Peru. The results can be linked to NMIs globally following CCT-K9, with NRC as the linking participant. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  11. The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail 'histone code' and Riz1 tumor suppressor function.

    Science.gov (United States)

    Congdon, Lauren M; Sims, Jennifer K; Tuzon, Creighton T; Rice, Judd C

    2014-04-01

    PR-Set7/Set8/KMT5a is the sole histone H4 lysine 20 monomethyltransferase (H4K20me1) in metazoans and is essential for proper cell division and genomic stability. We unexpectedly discovered that normal cellular levels of monomethylated histone H3 lysine 9 (H3K9me1) were also dependent on PR-Set7, but independent of its catalytic activity. This observation suggested that PR-Set7 interacts with an H3K9 monomethyltransferase to establish the previously reported H4K20me1-H3K9me1 trans-tail 'histone code'. Here we show that PR-Set7 specifically and directly binds the C-terminus of the Riz1/PRDM2/KMT8 tumor suppressor and demonstrate that the N-terminal PR/SET domain of Riz1 preferentially monomethylates H3K9. The PR-Set7 binding domain was required for Riz1 nuclear localization and maintenance of the H4K20me1-H3K9me1 trans-tail 'histone code'. Although Riz1 can function as a repressor, Riz1/H3K9me1 was dispensable for the repression of genes regulated by PR-Set7/H4K20me1. Frameshift mutations resulting in a truncated Riz1 incapable of binding PR-Set7 occur frequently in various aggressive cancers. In these cancer cells, expression of wild-type Riz1 restored tumor suppression by decreasing proliferation and increasing apoptosis. These phenotypes were not observed in cells expressing either the Riz1 PR/SET domain or PR-Set7 binding domain indicating that Riz1 methyltransferase activity and PR-Set7 binding domain are both essential for Riz1 tumor suppressor function.

  12. The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail ‘histone code’ and Riz1 tumor suppressor function

    Science.gov (United States)

    Congdon, Lauren M.; Sims, Jennifer K.; Tuzon, Creighton T.; Rice, Judd C.

    2014-01-01

    PR-Set7/Set8/KMT5a is the sole histone H4 lysine 20 monomethyltransferase (H4K20me1) in metazoans and is essential for proper cell division and genomic stability. We unexpectedly discovered that normal cellular levels of monomethylated histone H3 lysine 9 (H3K9me1) were also dependent on PR-Set7, but independent of its catalytic activity. This observation suggested that PR-Set7 interacts with an H3K9 monomethyltransferase to establish the previously reported H4K20me1-H3K9me1 trans-tail ‘histone code’. Here we show that PR-Set7 specifically and directly binds the C-terminus of the Riz1/PRDM2/KMT8 tumor suppressor and demonstrate that the N-terminal PR/SET domain of Riz1 preferentially monomethylates H3K9. The PR-Set7 binding domain was required for Riz1 nuclear localization and maintenance of the H4K20me1-H3K9me1 trans-tail ‘histone code’. Although Riz1 can function as a repressor, Riz1/H3K9me1 was dispensable for the repression of genes regulated by PR-Set7/H4K20me1. Frameshift mutations resulting in a truncated Riz1 incapable of binding PR-Set7 occur frequently in various aggressive cancers. In these cancer cells, expression of wild-type Riz1 restored tumor suppression by decreasing proliferation and increasing apoptosis. These phenotypes were not observed in cells expressing either the Riz1 PR/SET domain or PR-Set7 binding domain indicating that Riz1 methyltransferase activity and PR-Set7 binding domain are both essential for Riz1 tumor suppressor function. PMID:24423864

  13. 基于MapGIS K9的林业地图符号库构建及符号化实施%Construction of Symbol Database and Symboltzation Execution of Forestry Map Based on MapGIS K9

    Institute of Scientific and Technical Information of China (English)

    司瑶; 武红敢

    2011-01-01

    为提高林业地图的制图效率和智能化水平,笔者提出了基于MapGIS K9平台的林业地图符号化方案.首先按照国家林业局2010年10月颁布的构建林业地图符号库,然后建立符号配置规则库以实现数字环境下符号配置规则的表达,最后在Map-GIS Objects组件开发技术支持下实现了符号化模块,按照符号配置规则对林业专题数据进行可视化表达.实践证明该方案能够基本满足包括森林资源规划设计调查成果图在内的常见林业地图制图要求.%In order to improve the cartography efficiency and the intelligent level of foreatry map,we put lorward the symbolization scheme of forestry map based on MapGIS K9 plarform.Firstly,the symbol database of forestry map wad constructed according to《The Graphic Representation of Foreatry Map》which was issued by The National Forestry Bureau in October2010.Then,the symbol configuration rule database was established to realize the expression of symbol configuration rule in the digital environment.Finally,the symbolization module was realized based on MapGIS objects component development technology.Sccording to the symbol configuration fule,the rhematic data of foreatry were done the visualization.The practice proved that the scheme could basically satisfy the cartography requirements of common forestry maps which included the foreat management inventory map.

  14. ISTI Overview

    Energy Technology Data Exchange (ETDEWEB)

    Eidenbenz, Stephan Johannes [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-01-10

    The Information Science & Technology Institute (ISTI) enables the execution of LANL’s institutional IS&T pillar through revitalization of technical IS&T areas, recruiting, and retention of IS&T staff. ISTI manages, organizes, and/or provides funding for (1) summer schools, (2) university collaborations, (3) workshops, (4) the IS&T seminar series, (5) program development, and (6) the visualization collaboratory at LARP all with a focus on IS&T.

  15. MPI overview

    Energy Technology Data Exchange (ETDEWEB)

    Asai, Noboru [Fujitsu Shizuoka Engineering Ltd. (Japan)

    1998-03-01

    MPI is recognized as the message passing standard these days. Its facility consists of various communication ways and group communication and moreover parallel I/O and external interface, to grow up a large scale of specification. MPI is intended as a completion of message passing, and its specification is defined by MPI Forum organized by universities, laboratories, vendors, and users in USA or Europe. Parallel applications newly written will use MPI from now on. The characteristics of MPI specification are (1)flexibility of communication control by user, (2)availability for a large scale of development with multiple communication spaces, (3)utilization of enhanced communication such as derived data or collective operations, and moreover in MPI-2, (4)more efficient communication with one-sided, (5)one of the solutions for parallel I/O, and (6)consideration of external interface among different languages or machines. MPI specification is on the way to be completed, and has grown up rapidly. It seems that the enhancement has come to stable status after the MPI-2 was defined, but the real value for developing applications shall be evaluated just from now on. The ideal form for parallel programming is assumed as a combination of automatic parallelization and message passing. MPI must be one of the important partners, and expected to be refined including a mixture with data parallel programming. (author)

  16. Genome-wide ChIP-seq mapping and analysis of butyrate-induced H3K9 and H3K27 acetylation and epigenomic landscape alteration in bovine cells

    Science.gov (United States)

    Utilizing next-generation sequencing technology, combined with ChIP (Chromatin Immunoprecipitation) technology, we analyzed histone modification (acetylation) induced by butyrate and the large-scale mapping of the epigenomic landscape of normal histone H3 and acetylated histone H3K9 and H3K27. To d...

  17. Breast Cancer Overview

    Science.gov (United States)

    ... Cancer > Breast Cancer > Breast Cancer: Overview Request Permissions Breast Cancer: Overview Approved by the Cancer.Net Editorial Board , ... bean-shaped organs that help fight infection. About breast cancer Cancer begins when healthy cells in the breast ...

  18. 24 CFR 572.1 - Overview of HOPE 3.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Overview of HOPE 3. 572.1 Section... DEVELOPMENT COMMUNITY FACILITIES HOPE FOR HOMEOWNERSHIP OF SINGLE FAMILY HOMES PROGRAM (HOPE 3) General § 572.1 Overview of HOPE 3. The purpose of the HOPE for Homeownership of Single Family Homes program...

  19. Integration of Schools and Mental Health Systems: An Overview of the State Grants from the U.S. Department of Education Program

    Science.gov (United States)

    Center for Mental Health in Schools at UCLA, 2008

    2008-01-01

    In 2005, the U.S. Department of Education implemented a grant program for the Integration of Schools and Mental Health Systems. As described on the Department's website, "this program provides grants to SEAs, LEAs, and Indian tribes for the purpose of increasing student access to quality mental health care by developing innovative programs…

  20. Strategic Analysis Overview

    Science.gov (United States)

    Cirillo, William M.; Earle, Kevin D.; Goodliff, Kandyce E.; Reeves, J. D.; Stromgren, Chel; Andraschko, Mark R.; Merrill, R. Gabe

    2008-01-01

    NASA s Constellation Program employs a strategic analysis methodology in providing an integrated analysis capability of Lunar exploration scenarios and to support strategic decision-making regarding those scenarios. The strategic analysis methodology integrates the assessment of the major contributors to strategic objective satisfaction performance, affordability, and risk and captures the linkages and feedbacks between all three components. Strategic analysis supports strategic decision making by senior management through comparable analysis of alternative strategies, provision of a consistent set of high level value metrics, and the enabling of cost-benefit analysis. The tools developed to implement the strategic analysis methodology are not element design and sizing tools. Rather, these models evaluate strategic performance using predefined elements, imported into a library from expert-driven design/sizing tools or expert analysis. Specific components of the strategic analysis tool set include scenario definition, requirements generation, mission manifesting, scenario lifecycle costing, crew time analysis, objective satisfaction benefit, risk analysis, and probabilistic evaluation. Results from all components of strategic analysis are evaluated a set of pre-defined figures of merit (FOMs). These FOMs capture the high-level strategic characteristics of all scenarios and facilitate direct comparison of options. The strategic analysis methodology that is described in this paper has previously been applied to the Space Shuttle and International Space Station Programs and is now being used to support the development of the baseline Constellation Program lunar architecture. This paper will present an overview of the strategic analysis methodology and will present sample results from the application of the strategic analysis methodology to the Constellation Program lunar architecture.

  1. 基于Oracle和MapGIS K9平台的第二次土地调查(农村部分)市级数据库建设——以崇左市为例

    Institute of Scientific and Technical Information of China (English)

    陈兰康; 何钊

    2012-01-01

    市级数据库(农村部分)建设是第二次全国土地调查的一项重要内容,是国土资源信息化的基础,是实现国土资源管理方式根本转变和国土资源工作现代化的重要组成部分。本文以Oracle 11G、MapGIS K9平台为基础,数据库建库、管理系统平台采用MapGIS K9国土资源数据中心系统,完成崇左市第二次土地调查(农村部分)数据库建设工作。

  2. Effect of Foliage Top-dressing of Potassium on the Photosynthetic Rate of Apple Trees%根外施钾对K9苹果树光合速率的影响研究

    Institute of Scientific and Technical Information of China (English)

    徐立祥; 唐雪东; 刘晓嘉

    2010-01-01

    采用GPS-1便携式光合作用测定系统,研究K9苹果树生育期根外施K对其光合速率的影响.结果表明:K9苹果树光合速率日变化呈双峰曲线,且根外施K处理叶片净光合速率(Pn)明显高于对照,在一定程度可缓和"午休"现象,每次喷钾的作用可持续25 d左右.并且3次根外施K处理叶片光合速率明显高于根外1次施K和2次施K处理.

  3. Photoionization study of Ne-like K9+, Ca10+, Sc11+, Ti12+, V13+, Cr14+, Mn15+, and Fe16+ ions using the screening constant by unit nuclear charge method

    Science.gov (United States)

    Goyal, Arun; Khatri, Indu; Sow, Malick; Sakho, Ibrahima; Aggarwal, Sunny; Singh, A. K.; Mohan, Man

    2016-08-01

    Photoionization of the 2s22p6 (1S0) ground state of the Ne-like (Z=19-29) ions is presented in this paper. Resonance energies and total natural width of the 2s2p6np 1P series of the Ne-like K9+, Ca10+, Sc11+, Ti12+, V13+, Cr14+, Mn15+, and Fe16+are reported. All the calculations are made using the Screening constant by unit nuclear charge (SCUNC) formalism. New data for Ne-like K9+, Sc11+, Ti12+, V13+, Cr14+, and Mn15+ions are tabulated. Good agreements are found with available literature data.

  4. The National Cancer Institute's PREVENT Cancer Preclinical Drug Development Program: overview, current projects, animal models, agent development strategies, and molecular targets.

    Science.gov (United States)

    Shoemaker, Robert H; Suen, Chen S; Holmes, Cathy A; Fay, Judith R; Steele, Vernon E

    2016-02-01

    The PREVENT Cancer Preclinical Drug Development Program (PREVENT) is a National Cancer Institute, Division of Cancer Prevention (NCI, DCP)-supported program whose primary goal is to bring new cancer preventive interventions (small molecules and vaccines) and biomarkers through preclinical development towards clinical trials by creating partnerships between the public sector (eg, academia, industry) and DCP. PREVENT has a formalized structure for moving interventions forward in the prevention pipeline using a stage-gate process with go/no go decision points along the critical path for development. This review describes the structure of the program, its focus areas, and provides examples of projects currently in the pipeline.

  5. A CO32--containing, dimanganese-substituted silicotungstate trimer, K9[H14{SiW10MnIIMnIIIO38}3(CO3)]·39H2O.

    Science.gov (United States)

    Yang, Ling; Liu, Qisen; Ma, Pengtao; Niu, Jingyang; Wang, Jingping

    2015-08-14

    An unprecedented silicotungstate trimer K(9)[H(14){SiW(10)Mn(II)Mn(III)O(38)}(3)(CO(3))]·39H(2)O (1) has been successfully synthesized, in which the CO(3)(2-) resides inside the three Keggin {SiW(10)Mn(II)Mn(III)O(38)} units and the three O atoms serve as μ(2)-O atoms to connect with three Mn(III). Magnetic investigation indicates that 1 exhibits antiferromagnetic coupling.

  6. Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9 analysis in fine needle aspiration cell blocks and the review of the literature

    Directory of Open Access Journals (Sweden)

    Sule Canberk

    2015-01-01

    Full Text Available Introduction: DOG1 is a transmembrane protein originally "discovered on gastrointestinal stromal tumors," works as a calcium-activated chloride channel protein. There is a limited number of studies on the potential usage of this antibody in the diagnosis of salivary gland tumors on routine practice in cell blocks. The aim of this study was to search for the usefulness of K9 clone in oncocytic type tumors and review of the literature. Materials and Methods: Sixty-nine fine needle aspiration (FNA cytologic materials of predominantly oncocytic morphology salivary gland tumors; acinic cell carcinoma (AciCC (n = 8, adenoid cystic carcinoma (n = 2, pleomorphic adenoma (PA (n = 22, Warthin tumor (WT (n = 20, myoepithelioma (ME (n = 5, benign oncocytoma (BeO (n = 3, mucoepidermoid carcinoma (MEC (n = 7, mammary analog salivary gland carcinoma (n = 2 were immunostained with DOG1 (clone K9 stain. Results: Of the 8 AciCCs, 7 were observed apical-luminal positive staining, demonstrating 1-3 + intensity, and involving 40-70% of the tumor cells. One MEC of 7 (14%, 1 ME of 5 (20%, and 4 PA of 22 (18% showed weak (1+ cytoplasmic granular staining in 5-10% of the tumor cells. Pure oncocytic neoplasms (WT, BeO showed no expression with DOG1-K9. Conclusions: FNA is a common tool in the diagnosis and management of salivary gland tumors. DOG1-K9 clone was very useful with a unique staining pattern of apical-luminal positivity in the differential diagnosis of AciCC from other oncocytic salivary gland tumors.

  7. Early postnatal feed restriction reduces liver connective tissue levels and affects H3K9 acetylation state of regulated genes associated with protein metabolism in low birth weight pigs.

    Science.gov (United States)

    Nebendahl, Constance; Görs, Solvig; Albrecht, Elke; Krüger, Ricarda; Martens, Karen; Giller, Katrin; Hammon, Harald M; Rimbach, Gerald; Metges, Cornelia C

    2016-03-01

    Intrauterine growth retardation is associated with metabolic consequences in adulthood. Since our previous data indicate birth weight-dependent effects of feed restriction (R) on protein degradation processes in the liver, it should be investigated whether effects on connective tissue turnover are obvious and could be explained by global changes of histone H3K9me3 and H3K9ac states in regulated genes. For this purpose, female littermate pigs with low (U) or normal (N) birth weight were subjected to 3-week R (60% of ad libitum fed controls) with subsequent refeeding (REF) for further 5 weeks. The 3-week R-period induced a significant reduction of connective tissue area by 43% in the liver of U animals at 98 d of age, which was not found in age-matched N animals. Of note, after REF at 131 d of age, in previously feed-restricted U animals (UR), the percentage of mean connective tissue was only 53% of ad libitum fed controls (UK), indicating a persistent effect. In U animals, R induced H3K9 acetylation of regulated genes (e.g. XBP1, ERLEC1, GALNT2, PTRH2), which were inter alia associated with protein metabolism. In contrast, REF was mostly accompanied by deacetylation in U and N animals. Thus, our epigenetic data may give a first explanation for the observed birth weight-dependent differences in this connective tissue phenotype.

  8. Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.

    Science.gov (United States)

    Sewalt, Richard G A B; Lachner, Monika; Vargas, Mark; Hamer, Karien M; den Blaauwen, Jan L; Hendrix, Thijs; Melcher, Martin; Schweizer, Dieter; Jenuwein, Thomas; Otte, Arie P

    2002-08-01

    Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of gene activity. Two distinct human PcG complexes have been characterized. The EED/EZH2 PcG complex utilizes histone deacetylation to repress gene activity. The HPC/HPH PcG complex contains the HPH, RING1, BMI1, and HPC proteins. Here we show that vertebrate Polycomb homologs HPC2 and XPc2, but not M33/MPc1, interact with the histone lysine methyltransferase (HMTase) SUV39H1 both in vitro and in vivo. We further find that overexpression of SUV39H1 induces selective nuclear relocalization of HPC/HPH PcG proteins but not of the EED/EZH2 PcG proteins. This SUV39H1-dependent relocalization concentrates the HPC/HPH PcG proteins to the large pericentromeric heterochromatin domains (1q12) on human chromosome 1. Within these PcG domains we observe increased H3-K9 methylation. Finally, we show that H3-K9 HMTase activity is associated with endogenous HPC2. Our findings suggest a role for the SUV39H1 HMTase and histone H3-K9 methylation in the targeting of human HPC/HPH PcG proteins to modified chromatin structures.

  9. Structural dynamics and fluid flow in shell-and-tube heat exchangers. Summary and overview of a DOE/ECUT-sponsored research program

    Science.gov (United States)

    Wambsganss, M. W.; Halle, H.; Mulcahy, T. M.

    1985-12-01

    Objective of the research program is to contribute to the design and development of energy-efficient, reliable, and cost-competitive industrial shell-and-tube heat exchangers. This report highlights the many technical contributions of the DOE/ECUT-sponsored program, reviews industry's use of the program results, and identifies research needs. Vibration excitation mechanisms, fluid/structure coupling, and flow distribution are briefly reviewed to provide background information. To date, the program has focused on the development of data bases of tube vibration and pressure drop information, derived from tests of a specially designed industrial-size heat exchanger. The development of an improved prediction method for fluid-elastic instability thresholds and the numerical simulation and measurement of flow distribution have also been addressed. Gas and two-phase flow testing is among the future research needs identified; such testing would require substantial modifications to the existing Heat Exchanger Test Facility. Industrial support, leading to a DOE/industry co-sponsored research pr ogram, is sought to allow for required modifications to the test facility, subsequent gas and two-phase flow testing, and expansion of the program to include further development of vibration and flow distribution prediction methods and related research.

  10. Overview of the energy research and development program of the Federal Republic of Germany with special attention to coal utilization technology

    Energy Technology Data Exchange (ETDEWEB)

    Holighaus, R.

    1980-01-01

    The objectives, the content and the finding of the Energy Research and Development Program are outlined with special attention to coal utilization technology. The largest part of the program is borne by the Federal Ministry for Research and Technology. The distribution of pending program shows clearly the priority for 'Coal and other fossil sources' which in fact means coal, the only large domestic energy source. The development activities are divided into following sections (in the order of financial priority): electricity generation from coal, gas generation from coal, liquefaction of coal, coal production and direct combustion. The different development strategies which are applied in the individual fields of coal utilization are discussed in detail. Several newly developed technologies are now, or in the near future, ready for commercial application. From the developments the Federal Government also expects to increase the attractivity of German industries as partners of joint ventures with countries having large coal deposits.

  11. AVLIS documentation overview and tables of contents

    Energy Technology Data Exchange (ETDEWEB)

    1984-11-15

    Three documents constitute the executive summary series in Data Package III: this document (Documentation Overview and Tables of Contents (E001)) plus the AVLIS Production Plant Executive Summary (E010) and the AVLIS Production Plant Overall Design Report (E020). They provide progressively greater detail on the key information and conclusions contained within the data package. The Executive Summary and Overall Design Report present summaries of each Data Package III document. They are intended to provide a global overview of AVLIS Production Plant deployment including program planning, project management, schedules, engineering design, production, operations, capital cost, and operating cost. The purpose of Overview and Tables of Contents is threefold: to briefly review AVLIS goals for Data Package III documentation, to present an overview of the contents of the data package, and to provide a useful guide to information contained in the numerous documents comprising the package.

  12. Overview of the Department of Energy's research, development and demonstration program for the recovery of energy and materials from urban waste

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, A. S.

    1979-01-01

    This program is directed at improving and developing technologies that reprocess waste into fuels, metals, glass, paper, ammonia, glucose, fertilizers, and other energy-intensive products. Nontechnical issues relating to institutional, socio-economic, and legal constraints to resource recovery are also being investigated. This paper briefly describes the technological options available in the field of resource recovery. Some of the approximately 80 projects comprising the Urban Waste Technology Branch's R, D, and D program are discussed and related to the overall objectives of th branch. To facilitate this presentation, projects are grouped as being primarily related to mechanical, thermal, or biological processes. To date, the majority of R and D funding has been devoted to biological processes including anaerobic and enzymatic digestion, energy production and conservation in water and waste water treatment, and energy generation and recovery in sanitary landfills. However, demonstration activities, representing slightly less than half the program effort, are focused on the thermal/mechanical systems. DOE activities ar coordinated with the EPA and other Federal, state, and local efforts in resource recovery to ensure the development of an efficient and comprehensive national resource recovery program. If successful, approximately 3% of the nation's energy needs could be supplied by reprocessing wastes.

  13. Preparing for a "Next Generation" Evaluation of Independent Living Programs for Youth in Foster Care: Project Overview. OPRE Report No. 2014-71

    Science.gov (United States)

    McDaniel, Marla; Courtney, Mark E.; Pergamit, Michael R.; Lowenstein, Christopher

    2014-01-01

    Youth transitioning out of foster care and into adulthood need multiple supports to navigate the challenges they face. Over the past three decades, federal child welfare policy has significantly increased the availability of those supports. In 1999, the Chafee Foster Care Independence Program was created, increasing the amount of funds potentially…

  14. Armed Conflict in Syria: Overview and U.S. Response

    Science.gov (United States)

    2014-09-17

    Armed Conflict in Syria : Overview and U.S. Response Christopher M. Blanchard, Coordinator Specialist in Middle Eastern Affairs Carla E. Humud... Syria : Overview and U.S. Response 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...98) Prescribed by ANSI Std Z39-18 Armed Conflict in Syria : Overview and U.S. Response Congressional Research Service Summary The summer 2014

  15. User support services and network application development: An overview

    Science.gov (United States)

    Gary, J. Patrick

    1991-01-01

    An overview is given of the user support services and network application development. The overview consists of the background, elements of NASA Science Internet (NSI) with GSFC responsibility, GSFC element objectives, and a summary of current status and plans. A conclusion of the overview is that refinement to the objectives and plans of the NSI elements under GSFC responsibility is ongoing and will continue to be influenced by user input/feedback through meetings with NSIUWG and user discipline programs, etc.

  16. TA-55 and Sigma Overview

    Energy Technology Data Exchange (ETDEWEB)

    Spearing, Dane Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Safeguards Science and Technology Group (NEN-1)

    2016-11-29

    These are slides from a facility overview presentation for visiting agencies to Los Alamos National Laboratory (LANL). The TA-55 Plutonium Facility (PF-4) is discussed in detail. PF-4 is a unique resource for US plutonium programs. The basic design is flexible and has adapted to changing national needs. It is a robust facility with strong safety and security implementation. It supports a variety of national programs. It will continue for many years into the future. Sigma is then discussed in detail, which handles everything from hydrogen to uranium. It has been in long term service to the Nation (nearly 60 years). It has a flexible authorization basis to handle almost the entire periodic table. It has a wide breadth of prototyping and characterization capabilities. It has integrated program and line management.

  17. Kanto Gakuin University communication spotlight : An overview of the incorporated text material for the oral communication program in the College of Engineering

    OpenAIRE

    Lisa Gayle Bond

    2012-01-01

    This article discusses Kanto Gakuin University Communication Spotlight's incorporation as the text used for the College of Engineering's Oral Communication course in the compulsory English program for first-year students. This paper examines the changes and enhancements made to the original textbook,Communication Spotlight Speaking Strategies and Listening Skills Starter: Split Version A. At the end of each term,students were randomly selected to complete a questionnaire regarding the text an...

  18. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription factor activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism.

    Science.gov (United States)

    Ueda, Keiji; Ishikawa, Kayo; Nishimura, Ken; Sakakibara, Shuhei; Do, Eunju; Yamanishi, Koichi

    2002-12-01

    The replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, a homologue of Epstein-Barr virus BRLF1 or Rta, is a strong transactivator and inducer of lytic replication. RTA acting alone can induce lytic replication of KSHV in infected cell lines that originated from primary effusion lymphomas, leading to virus production. During the lytic replication process, RTA activates many kinds of genes, including polyadenylated nuclear RNA, K8, K9 (vIRF), ORF57, and so on. We focused here on the mechanism of how RTA upregulates the K9 (vIRF) promoter and identified two independent cis-acting elements in the K9 (vIRF) promoter that responded to RTA. These elements were finally confined to the sequence 5'-TCTGGGACAGTC-3' in responsive element (RE) I-2B and the sequence 5'-GTACTTAAAATA-3' in RE IIC-2, both of which did not share sequence homology. Multiple factors bound specifically with these elements, and their binding was correlated with the RTA-responsive activity. Electrophoretic mobility shift assay with nuclear extract from infected cells and the N-terminal part of RTA expressed in Escherichia coli, however, did not show that RTA interacted directly with these elements, in contrast to the RTA responsive elements in the PAN/K12 promoter region, the ORF57/K8 promoter region. Thus, it was likely that RTA could transactivate several kinds of unique cis elements without directly binding to the responsive elements, probably through cooperation with other DNA-binding factors.

  19. 5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.

    Science.gov (United States)

    Wozniak, R J; Klimecki, W T; Lau, S S; Feinstein, Y; Futscher, B W

    2007-01-04

    The epigenetic silencing of tumor suppressor genes is a common event during carcinogenesis, and often involves aberrant DNA methylation and histone modification of gene regulatory regions, resulting in the formation of a transcriptionally repressive chromatin state. Two examples include the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently silenced in this manner in human breast cancer. Treatment of the breast tumor cell lines MDA-MB-231 and UACC 1179 with 5-aza-2'-deoxycytidine (5-aza-CdR) induced transcriptional reactivation of both genes in a dose-dependent manner. Importantly, DSC3 and MASPIN reactivation was closely and consistently linked with significant decreases in promoter H3 K9 di-methylation. Moreover, 5-aza-CdR treatment also resulted in global decreases in H3 K9 di-methylation, an effect that was linked to its ability to mediate dose-dependent, post-transcriptional decreases in the key enzyme responsible for this epigenetic modification, G9A. Finally, small interfering RNA (siRNA)-mediated knockdown of G9A and DNMT1 led to increased MASPIN expression in MDA-MB-231 cells, to levels that were supra-additive, verifying the importance of these enzymes in maintaining multiple layers of epigenetic repression in breast tumor cells. These results highlight an additional, complimentary mechanism of action for 5-aza-CdR in the reactivation of epigenetically silenced genes, in a manner that is independent of its effects on DNA methylation, further supporting an important role for H3 K9 methylation in the aberrant repression of tumor suppressor genes in human cancer.

  20. Adapting the Australian system: is an organized screening program feasible in Malaysia?--an overview of cervical cancer screening in both countries.

    Science.gov (United States)

    Rashid, Rima Ma; Dahlui, Maznah; Mohamed, Majdah; Gertig, Dorota

    2013-01-01

    Cervical cancer is the third most common form of cancer that strikes Malaysian women. The National Cancer Registry in 2006 and 2007 reported that the age standardized incidence (ASR) of cervical cancer was 12.2 and 7.8 per 100,000 women, respectively. The cumulative risk of developing cervical cancer for a Malaysian woman is 0.9 for 74 years. Among all ethnic groups, the Chinese experienced the highest incidence rate in 2006, followed by Indians and Malays. The percentage cervical cancer detected at stage I and II was 55% (stage I: 21.0%, stage II: 34.0%, stage III: 26.0% and stage IV: 19.0%). Data from Ministry of Health Malaysia (2006) showed a 58.9% estimated coverage of pap smear screening conducted among those aged 30-49 years. Only a small percentage of women aged 50-59 and 50-65 years old were screened, 14% and 13.8% coverage, respectively. Incidence of cervical cancer was highest (71.6%) among those in the 60-65 age group (MOH, 2003). Currently, there is no organized population-based screening program available for the whole of Malaysia. A pilot project was initiated in 2006, to move from opportunistic cervical screening of women who attend antenatal and postnatal visits to a population based approach to be able to monitor the women through the screening pathway and encourage women at highest risk to be screened. The project was modelled on the screening program in Australia with some modifications to suit the Malaysian setting. Substantial challenges have been identified, particularly in relation to information systems for call and recall of women, as well as laboratory reporting and quality assurance. A cost-effective locally-specific approach to organized screening, that will provide the infrastructure for increasing participation in the cervical cancer screening program, is urgently required.

  1. YALINA facility a sub-critical Accelerator- Driven System (ADS) for nuclear energy research facility description and an overview of the research program (1997-2008).

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, Y.; Smith, D. L.; Nuclear Engineering Division

    2010-04-28

    The YALINA facility is a zero-power, sub-critical assembly driven by a conventional neutron generator. It was conceived, constructed, and put into operation at the Radiation Physics and Chemistry Problems Institute of the National Academy of Sciences of Belarus located in Minsk-Sosny, Belarus. This facility was conceived for the purpose of investigating the static and dynamic neutronics properties of accelerator driven sub-critical systems, and to serve as a neutron source for investigating the properties of nuclear reactions, in particular transmutation reactions involving minor-actinide nuclei. This report provides a detailed description of this facility and documents the progress of research carried out there during a period of approximately a decade since the facility was conceived and built until the end of 2008. During its history of development and operation to date (1997-2008), the YALINA facility has hosted several foreign groups that worked with the resident staff as collaborators. The participation of Argonne National Laboratory in the YALINA research programs commenced in 2005. For obvious reasons, special emphasis is placed in this report on the work at YALINA facility that has involved Argonne's participation. Attention is given here to the experimental program at YALINA facility as well as to analytical investigations aimed at validating codes and computational procedures and at providing a better understanding of the physics and operational behavior of the YALINA facility in particular, and ADS systems in general, during the period 1997-2008.

  2. 40 CFR 161.20 - Overview.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES General Provisions § 161.20 Overview. (a) Legal authority... Insecticide, Fungicide and Rodenticide Act, as amended (FIFRA) (7 U.S.C. 136-136y). (b) Purposes of this...

  3. Introduction: TQM Fundamentals and Overview of Contents.

    Science.gov (United States)

    Jurow, Susan; Barnard, Susan B.

    1993-01-01

    Discusses Total Quality Management (TQM), benefits to libraries, and possible barriers to its adoption. An overview is provided of 13 articles included in this issue on (1) library approaches to TQM; (2) implementing a TQM program; (3) supporting TQM efforts; and (4) learning from the experience of others. (EAM)

  4. Introduction: TQM Fundamentals and Overview of Contents.

    Science.gov (United States)

    Jurow, Susan; Barnard, Susan B.

    1993-01-01

    Discusses Total Quality Management (TQM), benefits to libraries, and possible barriers to its adoption. An overview is provided of 13 articles included in this issue on (1) library approaches to TQM; (2) implementing a TQM program; (3) supporting TQM efforts; and (4) learning from the experience of others. (EAM)

  5. Fims, forestry information management system: An overview

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This geographic information system has been developed as part of Forestry Canada's Eastern Quebec Forestry Program for woodlot owners in eastern Quebec. The goal was to provide private woodlot operators with a management system that uses the most advanced technology available. This booklet provides an overview of this system, explaining how the system can be used.

  6. 农村集体土地所有权登记发证MAPGIS K9入库前的框架搭建方法步骤

    Institute of Scientific and Technical Information of China (English)

    连金玲; 郭秋云; 惠以珩

    2013-01-01

    农村集体土地所有权工作入库工作是必不可少的一项内容,而枣庄市农村集体土地确权外业完成后的内业成图都是用的南方CASS8.0软件就,本文主要针对枣庄市农村集体土地所有权,利用MAPGIS K9入库前,由CASS8.0到MAGIS的入库准备工作,包括界址点、界址线转换到MAPGIS下,以及界址点、界址线、宗地属性的录入和挂接,为入库奠定良好的基础。框架搭建好后直接导入MAPGIS K9中完善库的内容。

  7. Kickstarting Choreographic Programming

    OpenAIRE

    Montesi, Fabrizio

    2015-01-01

    We present an overview of some recent efforts aimed at the development of Choreographic Programming, a programming paradigm for the production of concurrent software that is guaranteed to be correct by construction from global descriptions of communication behaviour.

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Opportunities Leadership Opportunities Leadership & Advocacy Summit Get Involved in ACS Surgeons as Leaders Course Webinars for Surgeons ... Quality Programs Overview About Quality Programs ACS Leadership in Quality ACS Leadership in Quality Inspiring Quality Initiative ...

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Safety Conference Registry Login SCR Training and Testing Cancer Cancer Programs Cancer Programs Overview of Cancer ... and FAQs Features of the SSR CMS Merit-Based Incentive Payment System MOC Part 4 and Recertification ...

  10. Information sciences and human factors overview

    Science.gov (United States)

    Holcomb, Lee B.

    1988-01-01

    An overview of program objectives of the Information Sciences and Human Factors Division of NASA's Office of Aeronautics and Space Technology is given in viewgraph form. Information is given on the organizational structure, goals, the research and technology base, telerobotics, systems autonomy in space operations, space sensors, humans in space, space communications, space data systems, transportation vehicle guidance and control, spacecraft control, and major program directions in space.

  11. The mammalian toxicological hazards of petroleum-derived substances: an overview of the petroleum industry response to the high production volume challenge program.

    Science.gov (United States)

    McKee, Richard H; White, Russell

    2014-01-01

    Petroleum-derived substances are complex and composed of aliphatic (normal-, iso-, and cycloparaffins), olefinic, and/or aromatic constituents. Approximately 400 of these complex substances were evaluated as part of the US Environmental Protection Agency voluntary High Production Volume (HPV) Challenge program. The substances were separated into 13 groups (categories), and all available data were assessed. Toxicology testing was conducted as necessary to fully address the end points encompassed by the HPV initiative. In a broad sense, volatile hydrocarbons may cause acute central nervous system effects, and those that are liquids at room temperature pose aspiration hazards if taken into the lungs as liquids and may also cause skin irritation. Higher boiling substances may contain polycyclic aromatic constituents (PACs) that can be mutagenic and carcinogenic and may also cause developmental effects. Substances containing PACs can also cause target organ and developmental effects. The effects of aliphatic constituents include liver enlargement and/or renal effects in male rats via an α-2u-globulin-mediated process and, in some cases, small but statistically significant reductions in hematological parameters. Crude oils may contain other constituents, particularly sulfur- and nitrogen-containing compounds, which are removed during refining. Aside from these more generic considerations, some specific petroleum substances may contain unusually toxic constituents including benzene, 1,3-butadiene, and/or n-hexane, which should also be taken into account if present at toxicologically relevant levels.

  12. Evolutionary Computation:ao Overview

    Institute of Scientific and Technical Information of China (English)

    HeZhenya; WeiChengjian

    1997-01-01

    Evolutionary computation is a field of simulating evolution on a computer.Both aspects of it ,the problem solving aspect and the aspect of modeling natural evolution,are important.Simulating evolution on a computer results in stochastic optimization techniques that can outperform classical methods of optimization when applied to difficult real-world problems.There are currently four main avenues of research in simulated evolution:genetic algorithms,evolutionary programming,evolution strategies,and genetic programming.This paper presents a brief overview of thd field on evolutionary computation,including some theoretical issues,adaptive mechanisms,improvements,constrained optimizqtion,constrained satisfaction,evolutionary neural networks,evolutionary fuzzy systems,hardware evolution,evolutionary robotics,parallel evolutionary computation,and co-evolutionary models.The applications of evolutionary computation for optimizing system and intelligent information processing in telecommunications are also introduced.

  13. Osteoporosis: An Overview.

    Science.gov (United States)

    Johnston, C. Conrad; Slemenda, Charles

    1987-01-01

    An overview of osteoporosis, its types, causes, diagnosis, and treatment is presented. Risk factors and bone mass measurement are also discussed. This article serves as an introduction to a symposium on osteoporosis containing five other articles in this issue. (MT)

  14. Overview of Rehabilitation

    Science.gov (United States)

    ... Organ Systems Additional Content Medical News Overview of Rehabilitation By Alex Moroz, MD, FACP, New York University School of Medicine;Rusk Rehabilitation NOTE: This is the Consumer Version. DOCTORS: Click ...

  15. Overview of Poisoning

    Science.gov (United States)

    ... Abbreviations Weights & Measures ENGLISH View Professional English Deutsch Japanese Espaniol Find information on medical topics, symptoms, drugs, ... Insecticide Poisoning Iron Poisoning Lead Poisoning Overview of Food Poisoning Mushroom (Toadstool) Poisoning Plant and Shrub Poisoning ...

  16. Computational Thinking in K-9 Education

    NARCIS (Netherlands)

    Mannila, Linda; Dagiene, Valentina; Demo, Barbara; Grgurina, Natasa; Mirolo, Claudio; Rolandsson, Lennart; Settle, Amber

    2014-01-01

    In this report we consider the current status of the coverage of computer science in education at the lowest levels of education in multiple countries. Our focus is on computational thinking (CT), a term meant to encompass a set of concepts and thought processes that aid in formulating problems and

  17. Overview of Specialized Courts

    OpenAIRE

    2009-01-01

    This Overview has two primary purposes. First, it provides judicial system officials with the arguments in favor of and in opposition to the creation of specialized courts. Second, it offers recommendations for consideration by judicial system officials when they are deliberating whether to establish specialized courts. This Overview also provides a review of types of specialized courts that have been established in court systems in some countries in Europe and the United States. This review ...

  18. TFAWS: Ares Thermal Overview

    Science.gov (United States)

    Sharp, John R.

    2007-01-01

    As part of a Constellation session at the 2007 Thermal & Fluids Analysis Workshop (TFAWS), an overview of the Crew Launch Vehicle (CLV), Crew Exploration Vehicle (CEV) and Lunar Lander systems will be given. This presentation provides a general description of the CLV (also known as Ares-I)and Ares-V vehicles portion of the session. The presentation will provide an overview of the thermal requirements, design environments, challenges and thermal modeling examples.

  19. Conformal Ablative Thermal Protection System for Planetary and Human Exploration Missions: Overview of the Technology Maturation Efforts Funded by NASA's Game Changing Development Program

    Science.gov (United States)

    Beck, Robin A.; Arnold, James O.; Gasch, Matthew J.; Stackpoole, Margaret M.; Fan, Wendy; Szalai, Christine E.; Wercinski, Paul F.; Venkatapathy, Ethiraj

    2012-01-01

    The Office of Chief Technologist (OCT), NASA has identified the need for research and technology development in part from NASA's Strategic Goal 3.3 of the NASA Strategic Plan to develop and demonstrate the critical technologies that will make NASA's exploration, science, and discovery missions more affordable and more capable. Furthermore, the Game Changing Development Program (GCDP) is a primary avenue to achieve the Agency's 2011 strategic goal to "Create the innovative new space technologies for our exploration, science, and economic future." In addition, recently released "NASA space Technology Roadmaps and Priorities," by the National Research Council (NRC) of the National Academy of Sciences stresses the need for NASA to invest in the very near term in specific EDL technologies. The report points out the following challenges (Page 2-38 of the pre-publication copy released on February 1, 2012): Mass to Surface: Develop the ability to deliver more payload to the destination. NASA's future missions will require ever-greater mass delivery capability in order to place scientifically significant instrument packages on distant bodies of interest, to facilitate sample returns from bodies of interest, and to enable human exploration of planets such as Mars. As the maximum mass that can be delivered to an entry interface is fixed for a given launch system and trajectory design, the mass delivered to the surface will require reduction in spacecraft structural mass; more efficient, lighter thermal protection systems; more efficient lighter propulsion systems; and lighter, more efficient deceleration systems. Surface Access: Increase the ability to land at a variety of planetary locales and at a variety of times. Access to specific sites can be achieved via landing at a specific location (s) or transit from a single designated landing location, but it is currently infeasible to transit long distances and through extremely rugged terrain, requiring landing close to the

  20. The Uranium from Seawater Program at the Pacific Northwest National Laboratory: Overview of Marine Testing, Adsorbent Characterization, Adsorbent Durability, Adsorbent Toxicity, and Deployment Studies

    Energy Technology Data Exchange (ETDEWEB)

    Gill, Gary A.; Kuo, Li-Jung; Janke, Chris J.; Park, Jiyeon; Jeters, Robert T.; Bonheyo, George T.; Pan, Horng-Bin; Wai, Chien; Khangaonkar, Tarang; Bianucci, Laura; Wood, Jordana R.; Warner, Marvin G.; Peterson, Sonja; Abrecht, David G.; Mayes, Richard T.; Tsouris, Costas; Oyola, Yatsandra; Strivens, Jonathan E.; Schlafer, Nicholas J.; Addleman, R. Shane; Chouyyok, Wilaiwan; Das, Sadananda; Kim, Jungseung; Buesseler, Ken; Breier, Crystal; D’Alessandro, Evan

    2016-02-07

    The Pacific Northwest National Laboratory’s (PNNL) Marine Science Laboratory (MSL) located along the coast of Washington State is evaluating the performance of uranium adsorption materials being developed for seawater extraction under realistic marine conditions with natural seawater. Two types of exposure systems were employed in this program: flow-through columns for testing of fixed beds of individual fibers and pellets and a recirculating water flume for testing of braided adsorbent material. Testing consists of measurements of the adsorption of uranium and other elements from seawater as a function of time, typically 42 to 56 day exposures, to determine the adsorbent capacity and adsorption rate (kinetics). Analysis of uranium and other trace elements collected by the adsorbents was conducted following strong acid digestion of the adsorbent with 50% aqua regia using either Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) or Inductively Coupled Plasma Mass Spectrometer (ICP-MS). The ORNL 38H adsorbent had a 56 day adsorption capacity of 3.30 ± 0.68 g U/ kg adsorbent (normalized to a salinity of 35 psu), a saturation adsorption capacity of 4.89 ± 0.83 g U/kg of adsorbent material (normalized to a salinity of 35 psu) and a half-saturation time of 28 ± 10 days. The AF1 adsorbent material had a 56 day adsorption capacity of 3.9 ± 0.2 g U/kg adsorbent material (normalized to a salinity of 35 psu), a saturation capacity of 5.4 ± 0.2 g U/kg adsorbent material (normalized to a salinity of 35 psu) and a half saturation time of 23 ± 2 days. The ORNL amidoxime-based adsorbent materials are not specific for uranium, but also adsorb other elements from seawater. The major doubly charged cations in seawater (Ca and Mg) account for a majority of the cations adsorbed (61% by mass and 74% by molar percent). For the ORNL AF1 adsorbent material, U is the 4th most abundant element adsorbed by mass and 7th most abundant by molar percentage