WorldWideScience

Sample records for k-9 program overview

  1. Program overview

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    The program overview describes the following resources and facilities; laser facilities, main laser room, target room, energy storage, laboratory area, building support systems, general plant project, and the new trailer complex

  2. Human Reliability Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  3. Vehicle Technologies Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-05

    Overview of the Vehicle Technologies Program including external assessment and market view; internal assessment, program history and progress; program justification and federal role; program vision, mission, approach, strategic goals, outputs, and outcomes; and performance goals.

  4. Research Program Overview

    Science.gov (United States)

    PEER logo Pacific Earthquake Engineering Research Center home about peer news events research products laboratories publications nisee b.i.p. members education FAQs links research Research Program Overview Tall Buildings Initiative Transportation Research Program Lifelines Program Concrete Grand

  5. NREL biofuels program overview

    Energy Technology Data Exchange (ETDEWEB)

    Mielenz, J.R. [National Renewable Energy Laboratory, Golden, CO (United States)

    1996-09-01

    The NREL Biofuels Program has been developing technology for conversion of biomass to transportation fuels with support from DOE Office of Transportation Technologies Biofuels System Program. This support has gone to both the National Renewable Energy Laboratory, and over 100 subcontractors in universities and industry. This overview will outline the value of the Biofuels development program to the Nation, the current status of the technology development, and what research areas still need further support and progress for the development of a biofuels industry in the US.

  6. 1996 ICF program overview

    International Nuclear Information System (INIS)

    Correll, D

    1996-01-01

    The continuing objective of the Inertial Confinement Fusion (ICF) Program is the demonstration of thermonuclear fusion ignition and energy gain in the laboratory. The underlying theme of all ICF activities as a science research and development program is the Department of Energy's (DOE's) Defense Programs (DP) science-based Stockpile Stewardship and Management (SSM) Program. The extension of current program research capabilities in the National Ignition Facility (NIF) is necessary for the ICF Program to satisfy its stewardship responsibilities. ICF resources (people and facilities) are increasingly being redirected in support of the performance, schedule, and cost goals of the NIF. One of the more important aspects of ICF research is the national nature of the program. Lawrence Livermore National Laboratory's (LLNL's) ICF Program falls within DOE's national ICF Program, which includes the Nova and Beamlet laser facilities at LLNL and the OMEGA, Nike, and Trident laser facilities at the University of Rochester (Laboratory for Laser Energetics, UR/LLE), the Naval Research Laboratory (NRL), and Los Alamos National Laboratory (LANL), respectively. The Particle Beam Fusion Accelerator (PBFA) and Saturn pulsed-power facilities are at Sandia National Laboratories (SNL). General Atomics, Inc. (GA) develops and provides many of the targets for the above experimental facilities. LLNL's ICF Program supports activities in two major interrelated areas: (1) target physics and technology (experimental, theoretical, and computational research); and (2) laser science and optics technology development. Experiments on LLNL's Nova laser primarily support ignition and weapons physics research. Experiments on LLNL's Beamlet laser support laser science and optics technology development. In addition, ICF sciences and technologies, developed as part of the DP mission goals, continue to support additional DOE objectives. These objectives are (1) to achieve diversity in energy sources

  7. Wind energy program overview

    International Nuclear Information System (INIS)

    1992-02-01

    This overview emphasizes the amount of electric power that could be provided by wind power rather than traditional fossil fuels. New wind power markets, advances in technology, technology transfer, and wind resources are some topics covered in this publication

  8. Federal Energy Management Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2017-08-05

    Brochure offers an overview of the Federal Energy Management Program (FEMP), which provides agencies and organizations with the information, tools, and assistance they need to achieve their energy-related requirements and goals through specialized initiatives.

  9. SSCL quality program overview

    International Nuclear Information System (INIS)

    Hedderick, R.V.; Threatt, D.C.

    1992-01-01

    The Quality Program for the Superconducing Super Collider Laboratory (SSCL) was developed for a number of reasons. The need for a quality program not only is a contractual requirement, but it also makes good economic sense to implement such a program. The quality program is the device used to coordinate the activities of different Laboratory organizations, such as Engineering and Procurement, and to improve operational reliability and safety. To be successful, the QA Program not only must satisfy Department of Energy (DOE) requirements and provide for flowdown of requirements to performing organizations, but must also be flexible enough so that the program is tailored to meet the needs of each internal organization. The keys to success are management support, acceptance by personnel, and cost effectiveness. These three items are assured by involving appropriate management at each step of program development, by personnel training and by feedback, and by programs to reduce defects and improve quality. Equally valuable is involvement of key organizations in program development. We will describe the basic SSCL Quality Program requirements, how the requirements are tailored to the needs of Laboratory organizations, and how the effectiveness of the program is validated

  10. SP-100 Program overview

    International Nuclear Information System (INIS)

    Truscello, V.C.

    1984-01-01

    The SP-100 Program is expected to go through three phases: technology assessment and advancement, ground testing, and flight qualification. Currently the program is in the two- to three-year technology assessment and advancement stage. Goals are to identify the space nuclear power system concept that best meets anticipated requirements of future space missions, assess the technical feasibility of that concept, and establish a cost and schedule for developing the concept. The SP-100 Project Office has begun the implementation activities needed to meet these goals. With regard to refractory alloys, a better data base will be required before we move ahead in the program from technology assessment to ground demonstration

  11. 2007 Biomass Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    The Biomass Program is actively working with public and private partners to meet production and technology needs. With the corn ethanol market growing steadily, researchers are unlocking the potential of non-food biomass sources, such as switchgrass and forest and agricultural residues. In this way, the Program is helping to ensure that cost-effective technologies will be ready to support production goals for advanced biofuels.

  12. Program overview: Subsurface science program

    International Nuclear Information System (INIS)

    1994-03-01

    The OHER Subsurface Science Program is DOE's core basic research program concerned with subsoils and groundwater. These practices have resulted in contamination by mixtures of organic chemicals, inorganic chemicals, and radionuclides. A primary long-term goal is to provide a foundation of knowledge that will lead to the reduction of environmental risks and to cost-effective cleanup strategies. Since the Program was initiated in 1985, a substantial amount of research in hydrogeology, subsurface microbiology, and the geochemistry of organically complexed radionuclides has been completed, leading to a better understanding of contaminant transport in groundwater and to new insights into microbial distribution and function in the subsurface environments. The Subsurface Science Program focuses on achieving long-term scientific advances that will assist DOE in the following key areas: providing the scientific basis for innovative in situ remediation technologies that are based on a concept of decontamination through benign manipulation of natural systems; understanding the complex mechanisms and process interactions that occur in the subsurface; determining the influence of chemical and geochemical-microbial processes on co-contaminant mobility to reduce environmental risks; improving predictions of contaminant transport that draw on fundamental knowledge of contaminant behavior in the presence of physical and chemical heterogeneities to improve cleanup effectiveness and to predict environmental risks

  13. Laser fusion program overview

    International Nuclear Information System (INIS)

    Emmett, J.L.

    1977-01-01

    This program is structured to proceed through a series of well defined fusion milestones to proof of the scientific feasibility, of laser fusion with the Shiva Nova system. Concurrently, those key technical areas, such as advanced lasers, which are required to progress beyond proof of feasibility, are being studied. We have identified and quantified the opportunities and key technical issues in military applications, such as weapons effects simulations, and in civilian applications, such as central-station electric power production. We summarize the current status and future plans for the laser fusion program at LLL, emphasizing the civilian applications of laser fusion

  14. Better Plants Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-09-30

    The U.S. Department of Energy’s (DOE’s) Better Buildings, Better Plants Program is a voluntary partnership initiative to drive significant energy efficiency improvement across energy intensive companies and organizations. 157 leading manufacturers and public water and wastewater treatment utilities are partnering with DOE through Better Plants to improve energy efficiency, slash carbon emissions, and cut energy costs.

  15. Fusion program overview

    International Nuclear Information System (INIS)

    Clarke, J.F.

    1983-01-01

    There has been and continues to be a perceived need for the fusion energy option in our energy future. The National Energy Plan states that ''the Federal Government recognizes a direct responsibility to demonstrate the scientific and engineering feasibility of fusion''. The goal of the program, in exercising this responsibility, is to develop the knowledge base upon which decisions on the commercial feasibility of fusion will be made after the conclusion of the present scientific feasibility phase of the program. The strategy is to preceed sequentially through a product definition phase, to the product development phase. Product definition is the identification of an attractive fusion reactor concept supported by a sound base of scientific and technological information. Product development is the further refinement of scientific, technological and engineering information base of the selected concept to provide a firm basis for commercial application. Each of these phases will be discussed with special emphasis on the relationship between the annual appropriation process and the influence of external forces on the pace of the program. This discussion will include the use of international cooperation to maintain and extend program scope. Further discussion will cover the important scientific and technological advances of the last few years and the way in which they have influenced the development of our management strategy to maximize our resources

  16. Hydrogen program overview

    Energy Technology Data Exchange (ETDEWEB)

    Gronich, S. [Dept. of Energy, Washington, DC (United States). Office of Utility Technologies

    1997-12-31

    This paper consists of viewgraphs which summarize the following: Hydrogen program structure; Goals for hydrogen production research; Goals for hydrogen storage and utilization research; Technology validation; DOE technology validation activities supporting hydrogen pathways; Near-term opportunities for hydrogen; Market for hydrogen; and List of solicitation awards. It is concluded that a full transition toward a hydrogen economy can begin in the next decade.

  17. Geothermal Energy Program overview

    International Nuclear Information System (INIS)

    1991-12-01

    The mission of the Geothermal Energy Program is to develop the science and technology necessary for tapping our nation's tremendous heat energy sources contained with the Earth. Geothermal energy is a domestic energy source that can produce clean, reliable, cost- effective heat and electricity for our nation's energy needs. Geothermal energy -- the heat of the Earth -- is one of our nation's most abundant energy resources. In fact, geothermal energy represents nearly 40% of the total US energy resource base and already provides an important contribution to our nation's energy needs. Geothermal energy systems can provide clean, reliable, cost-effective energy for our nation's industries, businesses, and homes in the form of heat and electricity. The US Department of Energy's (DOE) Geothermal Energy Program sponsors research aimed at developing the science and technology necessary for utilizing this resource more fully. Geothermal energy originates from the Earth's interior. The hottest fluids and rocks at accessible depths are associated with recent volcanic activity in the western states. In some places, heat comes to the surface as natural hot water or steam, which have been used since prehistoric times for cooking and bathing. Today, wells convey the heat from deep in the Earth to electric generators, factories, farms, and homes. The competitiveness of power generation with lower quality hydrothermal fluids, geopressured brines, hot dry rock, and magma ( the four types of geothermal energy) still depends on the technical advancements sought by DOE's Geothermal Energy Program

  18. Laser program overview

    International Nuclear Information System (INIS)

    Storm, E.; Coleman, L.W.

    1985-01-01

    The objectives of the Lawrence Livermore National Laboratory Laser Fusion program are to understand and develop the science and technology of inertial confinement fusion (ICF), and to utilize ICF in short- and long-term military applications, and, in the long-term, as a candidate for central-station civilian power generation. In 1984, using the Novette laser system, the authors completed experiments showing the very favorable scaling of laser-plama interactions with short-wavelength laser light. Their Novette experiments have unequivocally shown that short laser wavelength, i.e., less than 1 μm, is required to provide the drive necessary for efficient compression, ignition, and burn of DT fusion fuel. In other experiments with Novette, the authors made the first unambiguous observation of amplified spontaneous emission in the soft x-ray regime. The authors also conducted military applications and weapons physics experiments, which they discuss in detail in the classified volume of our Laser Program Annual Report. In the second thrust, advanced laser studies, they develop and test the concepts, components, and materials for present and future laser systems. Over the years, this has meant providing the technology base and scientific advances necessary to construct and operate a succession of six evermore-powerful laser systems. The latest of these, Nova, a 100-TW/100-kJ-class laser system, was completed in 1984. The Nd:glass laser continues to be the most effective and versatile tool for ICF and weapons physics because of its scalability in energy, the ability to efficiently convert its 1=μm output to shorter wavelengths, its ability to provide flexible, controlled pulse shaping, and its capability to adapt to a variety of irradiation and focusing geometries. For these reasons, many of our advanced laser studies are in areas appropriate to solid state laser technologies

  19. Commercial Crew Development Program Overview

    Science.gov (United States)

    Russell, Richard W.

    2011-01-01

    NASA's Commercial Crew Development Program is designed to stimulate efforts within the private sector that will aid in the development and demonstration of safe, reliable, and cost-effective space transportation capabilities. With the goal of delivery cargo and eventually crew to Low Earth Orbit (LEO) and the International Space Station (ISS) the program is designed to foster the development of new spacecraft and launch vehicles in the commercial sector. Through Space Act Agreements (SAAs) in 2011 NASA provided $50M of funding to four partners; Blue Origin, The Boeing Company, Sierra Nevada Corporation, and SpaceX. Additional, NASA has signed two unfunded SAAs with ATK and United Space Alliance. This paper will give a brief summary of these SAAs. Additionally, a brief overview will be provided of the released version of the Commercial Crew Development Program plans and requirements documents.

  20. USNRC HTGR safety research program overview

    International Nuclear Information System (INIS)

    Foulds, R.B.

    1982-01-01

    An overview is given of current activities and planned research efforts of the US Nuclear Regulatory Commission (NRC) HTGR Safety Program. On-going research at Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory, and Pacific Northwest Laboratory are outlined. Tables include: HTGR Safety Issues, Program Tasks, HTGR Computer Code Library, and Milestones for Long Range Research Plan

  1. Geothermal Technologies Program Overview - Peer Review Program

    Energy Technology Data Exchange (ETDEWEB)

    Milliken, JoAnn [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-06

    This Geothermal Technologies Program presentation was delivered on June 6, 2011 at a Program Peer Review meeting. It contains annual budget, Recovery Act, funding opportunities, upcoming program activities, and more.

  2. Seismic safety margins research program overview

    International Nuclear Information System (INIS)

    Tokarz, F.J.; Smith, P.D.

    1978-01-01

    A multiyear seismic research program has been initiated at the Lawrence Livermore Laboratory. This program, the Seismic Safety Margins Research Program (SSMRP) is funded by the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. The program is designed to develop a probabilistic systems methodology for determining the seismic safety margins of nuclear power plants. Phase I, extending some 22 months, began in July 1978 at a funding level of approximately $4.3 million. Here we present an overview of the SSMRP. Included are discussions on the program objective, the approach to meet the program goal and objectives, end products, the probabilistic systems methodology, and planned activities for Phase I

  3. NASA/FAA Tailplane Icing Program Overview

    Science.gov (United States)

    Ratvasky, Thomas P.; VanZante, Judith Foss; Riley, James T.

    1999-01-01

    The effects of tailplane icing were investigated in a four-year NASA/FAA Tailplane Icing, Program (TIP). This research program was developed to improve the understanding, of iced tailplane aeroperformance and aircraft aerodynamics, and to develop design and training aides to help reduce the number of incidents and accidents caused by tailplane icing. To do this, the TIP was constructed with elements that included icing, wind tunnel testing, dry-air aerodynamic wind tunnel testing, flight tests, and analytical code development. This paper provides an overview of the entire program demonstrating the interconnectivity of the program elements and reports on current accomplishments.

  4. A topaz international program overview

    Science.gov (United States)

    Thome, Frank V.; Wyant, Francis J.; Mulder, Daniel; McCarson, T. D.; Ponomarev-Stepnoi, Nikolai Nikolaevich

    1995-01-01

    Five years ago, during the 8th Symposium on Space Nuclear Power Systems, in Albuquerque, NM, Academician Nikolai Nikolaevich Ponomarev-Stepnoi, First Deputy Director of the Russian Research Center, Kurchatov Institute, proposed the sale of the Soviety Union's TOPAZ II technology to the United States. This proposal, made at great personal risk, was initially viewed with much skepticism by most Americans attending that conference since the Cold War was still in full swing. There were, however, a few visionaries, some would say fanatics, that set about to make this sale possible. Even these visionaries did not anticipate the collapse of the Soviet Union or the subsequent efforts by the U.S. and other Western powers to help the Newly Independent States transition to a market economy. Little did these visionaries know that the formation of the ``TOPAZ II Program,'' using former military space power technology of the Soviet Union, would become the preeminent example of technology cooperation between two former adversaries. A unique teaming arrangement formed in New Mexico, called the New Mexico Strategic Alliance and consisting of the Air Force Phillips Laboratory, Sandia National Laboratories, the University of New Mexico, and Los Alamos Nationalo Laboratory, was a key ingredient in making this program a success. A brief summary of some of the highlights of this technology partnership is given to explain how international patnerships of this type can enable commercialization and technology transfer.

  5. The ESCOMPTE program: an overview

    Science.gov (United States)

    Cros, B.; Durand, P.; Cachier, H.; Drobinski, Ph.; Fréjafon, E.; Kottmeier, C.; Perros, P. E.; Peuch, V.-H.; Ponche, J.-L.; Robin, D.; Saı̈d, F.; Toupance, G.; Wortham, H.

    2004-01-01

    In this paper, the "Expérience sur Site pour COntraindre les Modèles de Pollution atmosphérique et de Transport d'Emissions" (ESCOMPTE) program is presented. The ESCOMPTE program is used to produce a relevant set of data for testing and evaluating regional pollution models. It includes high-resolution (in space and time) atmospheric emission inventories and field experiments, and covers an area of 120×120 km, centered over the Marseilles-Berre area in the southeast of France during Summer 2001. This region presents a high occurrence of photochemical pollution events, which result from numerous industrial and urban sources of primary pollutants. From the dynamical characteristics of the area, sea-breeze circulation and channeling effects due to terrain features highly influence the location of the pollutant plumes. ESCOMPTE will provide a highly documented framework for dynamics and chemistry studies. Campaign strategies and experimental set up are described. During the planning phase, existing modeling results helped defining the experimental design. The campaign involved surface measurement networks, remote sensing, ship-borne, balloon-borne, and airplane measurements. Mean standard meteorological parameters and turbulent fluxes, ozone, ozone precursors, photochemically active trace gases, and aerosols were measured. Five intensive observation periods (IOPs) were documented using a wide spectrum of instruments, involving aircraft (7) (one of them equipped with a Doppler lidar, the others for in situ meteorological and chemical measurements), constant volume balloons (33), ozone lidars (5), wind profilers (15 sodars and radars), Doppler scanning lidar (1), radiosonde systems (at 4 locations), instrumented ships (2). In addition to the air quality networks from environmental agencies, 15 supplementary ground stations equipped for chemistry and/or meteorology and/or surface flux measurements, were operational. All instruments were calibrated and compared during a

  6. Overview of Department of Energy programs

    International Nuclear Information System (INIS)

    Hill, J.R.

    1985-01-01

    An overview is presented of policies and standards of the US DOE in the protection of the public, government employees, and government property from damage caused by natural phenomena. Included are Department of Energy orders covering policy and standards for natural phenomena hazards mitigation and Office of Nuclear Safety projects related to natural phenomena hazards mitigation. National Federal programs, committees, and reports are listed. 18 references

  7. The NASA Aviation Safety Program: Overview

    Science.gov (United States)

    Shin, Jaiwon

    2000-01-01

    In 1997, the United States set a national goal to reduce the fatal accident rate for aviation by 80% within ten years based on the recommendations by the Presidential Commission on Aviation Safety and Security. Achieving this goal will require the combined efforts of government, industry, and academia in the areas of technology research and development, implementation, and operations. To respond to the national goal, the National Aeronautics and Space Administration (NASA) has developed a program that will focus resources over a five year period on performing research and developing technologies that will enable improvements in many areas of aviation safety. The NASA Aviation Safety Program (AvSP) is organized into six research areas: Aviation System Modeling and Monitoring, System Wide Accident Prevention, Single Aircraft Accident Prevention, Weather Accident Prevention, Accident Mitigation, and Synthetic Vision. Specific project areas include Turbulence Detection and Mitigation, Aviation Weather Information, Weather Information Communications, Propulsion Systems Health Management, Control Upset Management, Human Error Modeling, Maintenance Human Factors, Fire Prevention, and Synthetic Vision Systems for Commercial, Business, and General Aviation aircraft. Research will be performed at all four NASA aeronautics centers and will be closely coordinated with Federal Aviation Administration (FAA) and other government agencies, industry, academia, as well as the aviation user community. This paper provides an overview of the NASA Aviation Safety Program goals, structure, and integration with the rest of the aviation community.

  8. Introduction and overview of research program

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The research goals have remained the same over the last several years: (1) to provide data which rigorously test proton + nucleus (pA) reaction models appropriate for medium energies (nonrelativistic and relativistic); (2) to provide data and appropriate analyses of it to obtain new, unambiguous information about the details of nuclear structure and reaction mechanisms (this information, in turn, can be used to test fundamental models of nuclear structure and effective interactions); (3) to provide proton + nucleon data which help constrain the nucleon-nucleon phase shift solutions, and (4) to develop and improve the pA models themselves. For this reason, since its conception in 1976, our program has held to the pragmatic philosophy that precise, reliable experimental data and state-of-the-art theoretical analyses are of equal importance. Thus, experiment and theory have merged to play complementary and closely linked roles in our studies to date; this philosophy is not expected to change in the future. A schematic overview indicating the framework in which the research program operates is shown and discussed

  9. NASA Technology Demonstrations Missions Program Overview

    Science.gov (United States)

    Turner, Susan

    2011-01-01

    , more than 70% of the TDM funds will be competitively awarded as a result of yearly calls for proposed flight demonstrators and selected based on possible payoff to NASA, technology maturity, customer interest, cost, and technical risk reduction. This paper will give an overview of the TDM Program s mission and organization, as well as its current status in delivering advanced space technologies that will enable more flexible and robust future missions. It also will provide several examples of missions that fit within these parameters and expected outcomes.

  10. Natural Programming: Project Overview and Proposal

    National Research Council Canada - National Science Library

    Myers, Brad

    1998-01-01

    .... The Natural Programming Project is developing general principles, methods, and programming language designs that will significantly reduce the amount of learning and effort needed to write programs...

  11. DOE Solar Energy Technologies Program: Overview and Highlights

    Energy Technology Data Exchange (ETDEWEB)

    2006-05-01

    A non-technical overview of the U.S. Department of Energy's Solar Energy Technologies Program, including sections on photovoltaics (PV), concentrating solar power, and solar heating and lighting R&D.

  12. Natural Programming: Project Overview and Proposal

    National Research Council Canada - National Science Library

    Myers, Brad

    1998-01-01

    End-users must write programs to control many different kinds of applications. Examples include multimedia authoring, controlling robots, defining manufacturing processes, setting up simulations, programming agents, scripting, etc...

  13. Human genome program report. Part 1, overview and progress

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report contains Part 1 of a two-part report to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 consists of the program overview and report on progress.

  14. An Overview of Head Start Program Studies

    Science.gov (United States)

    Hines, Jeanne Morris

    2017-01-01

    Johnson's "War on Poverty" administrative team campaigned for committee members to join the War on Poverty efforts to create and develop programs for children born into poverty (Zigler, 2003). Poverty based programs, such as the Head Start program, continue to put into place proactive measures to increase preschooler's cognitive…

  15. Overview of the NRC performance monitoring program

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1987-01-01

    In response to the accident at Three Mile Island, the NRC developed the Systematic Assessment of Licensee Performance (SALP) Program to aid in the identification of those licensees that were more likely than others to have safety problems and to provide a rational basis for allocation of inspection resources. The NRC also has an ongoing program of screening and evaluating operating reactor event reports on a daily basis for promptly identifying safety problems. Although the SALP and event report evaluation programs have been successful in identifying potential performance problems, a concern developed recently about the adequacy and timeliness of NRC programs to detect poor or declining performance. The performance indicator program as approved by the commission is in the implementation phase. The program is expected to undergo refinements as new indicators are developed and experience is gained in the use of indicators

  16. Overview of Advanced Turbine Systems Program

    Science.gov (United States)

    Webb, H. A.; Bajura, R. A.

    The US Department of Energy initiated a program to develop advanced gas turbine systems to serve both central power and industrial power generation markets. The Advanced Turbine Systems (ATS) Program will lead to commercial offerings by the private sector by 2002. ATS will be developed to fire natural gas but will be adaptable to coal and biomass firing. The systems will be: highly efficient (15 percent improvement over today's best systems); environmentally superior (10 percent reduction in nitrogen oxides over today's best systems); and cost competitive (10 percent reduction in cost of electricity). The ATS Program has five elements. Innovative cycle development will lead to the demonstration of systems with advanced gas turbine cycles using current gas turbine technology. High temperature development will lead to the increased firing temperatures needed to achieve ATS Program efficiency goals. Ceramic component development/demonstration will expand the current DOE/CE program to demonstrate industrial-scale turbines with ceramic components. Technology base will support the overall program by conducting research and development (R&D) on generic technology issues. Coal application studies will adapt technology developed in the ATS program to coal-fired systems being developed in other DOE programs.

  17. An overview of the Structural Aging Program

    International Nuclear Information System (INIS)

    Naus, D.J.; Arndt, E.G.

    1992-01-01

    The structural Aging Program is conducted at the Oak Ridge National Laboratory (ORNL) for the Nuclear Regulatory Commission (NRC). The program has the overall objective of preparing an expandable handbook or report which will provide NRC with potential structural safety issues and acceptance criteria for use in nuclear power plant evaluations for continued service. Initial focus of the program is on concrete and concrete-related materials which comprise safety-related (Category I) structures in light-water reactor facilities. The program is organized into four tasks: Task S.1 -- Program Management, Task S.2 -- Materials Property Data Base, Task S.3 -- Structural Component Assessment/Repair Technology, and Task S.4 -- Quantitative Methodology for Continued Service Determinations. Objectives, background information, and accomplishments under each of these tasks are presented

  18. DOD's advanced thermionics program an overview

    International Nuclear Information System (INIS)

    Drake, T.R.

    1998-01-01

    The Defense Special Weapons Agency (DSWA) manages a congressionally mandated program in advanced thermionics research. Guided by congressional language to advance the state-of-the-art in the US and support the Integrated Solar Upper Stage (ISUS) program, DSWA efforts concentrate on four areas: an electrically testable design of a high-performance, in-core thermionic fuel element (TFE), the ISUS program, a microminiature thermionic converter and several modeling efforts. The DSWA domestic program is augmented by several small contracts with Russian institutes, awarded under the former TOPAZ International Program that the Ballistic Missile Defense Organization transferred to DSWA. The design effort at General Atomics will result in an electrically testable, multi-cell TFE for in-core conversion, involving system design and advanced collector and emitter technologies. For the ISUS program, DSWA funded a portion of the engine ground demonstration, including development of the power management system and the planar diodes. Current efforts supporting ISUS include continued diode testing and developing an advanced planar diode. The MTC program seeks to design a mass producable, close-spaced thermionic converter using integrated circuit technologies. Modeling and analysis at DSWA involves development of the Reactor System Mass with Thermionics estimation model (RSMASS-T), developing a new thermionic theory, and reviewing applications for the MTC technology. The Russian deliverables include several reports and associated hardware that describe many of its state-of-the-art thermionic technologies and processes

  19. Overview of EPRI's human factors research program

    International Nuclear Information System (INIS)

    O'Brien, J.F.; Parris, H.L.

    1981-01-01

    The human factors engineering program in the Nuclear Power Division, EPRI is dedicated to the resolution of man-machine interface problems specific to the nuclear power industry. Particularly emphasis is placed on the capabilities and limitations of the people who operate and maintain the system, the tasks they must perform, and what they need to accomplish those tasks. Six human factors R and D projects are being conducted at the present time. In addition, technical consultation is being furnished to a study area, operator aids, being funded by another program area outside the human factors program area. All of these activities are summarized

  20. AUA Program Master Plan. Volume 1: Overview

    Science.gov (United States)

    1997-03-01

    The Office of Air Traffic Systems Development (AUA) Program Master Plan : summarizes the management, development approach, and status of products and : services provided by the AUA organization to fulfill its role in supporting : National Airspace Sy...

  1. Overview of the DOE nuclear data program

    International Nuclear Information System (INIS)

    Whetstone, S.L.

    1991-01-01

    Numerous researchers receive support from the US Department of Energy's (DOE's) nuclear data program; others work closely with it, attending coordination meetings and contributing to data activities. Since fiscal year (FY) 1988, the nuclear data program has been included in the budget of the Division of Nuclear Physics in the DOE's Office of High Energy and Nuclear Physics. The budget for nuclear data consists of two budget categories: nuclear data compilation and evaluation and nuclear data measurements, both of which are contained within the low-energy nuclear physics program. The program has become essentially the sole supporter of the National Nuclear Data Center at Brookhaven National Laboratory. The Center coordinates the production of the ENSDF data base and Nuclear Data Sheets as well as, through the Cross Section Evaluation Working Group (CSEWG138), the production of the ENDF. Two rather large accelerator facilities, completely supported by the program, the Oak Ridge Electron Linear Accelerator and the fast neutron generator at Argonne National Laboratory, form the core of the nuclear data measurement activity together with measurement programs at Los Alamos National Laboratory's LAMPF/WNR facility, and at accelerator laboratories at Ohio University, Duke University, the University of Lowell, the University of Michigan, and the Colorado School of Mines. Some history is discussed and future modernizing plans are identified

  2. Overview of international fusion technology programs

    International Nuclear Information System (INIS)

    Coffman, F.E.; Baublitz, J.E.; Beard, D.S.; Cohen, M.M.; Dalder, E.N.C.; Finfgeld, C.R.; Haas, G.M.; Head, C.R.; Murphy, M.R.; Nardella, G.R.

    1979-01-01

    World fusion technology programs, as well as current progress and future plans for the U.S., are discussed. Regarding conceptual design, the international INTOR tokamak study, the Garching Ignition Test Reactor Study, the U.S. Engineering Test Facility conceptual design, the Argonne National Laboratory Commercial Tokamak Study, mirror conceptual designs, and alternate concepts and applications studies are summarized. With regard to magnetics, progress to date in the large coil program and pulsed coil program is summarized. In the area of plasma heating and fueling and exhaust, work on a new positive ion source research and development program at Lawrence Berkeley Laboratory and Oak Ridge National Laboratory is described, as is negative ion work. Tradeoff considerations for radio-frequency heating alternatives are made, and a new 60-100 GHz electron cyclotron heating research and development program is discussed. Progress and plans for solid hydrogen pellet injector development are analyzed, as are plans for a divertor technology initiative. A brief review of the U.S. alternate applications and environment and safety program is included

  3. Employee assistance programs: an overview and suggested roles for psychiatrists.

    Science.gov (United States)

    Brill, P; Herzberg, J; Speller, J L

    1985-07-01

    Although employee assistance programs are rapidly becoming the predominant vehicle for the delivery of mental health services in occupational settings, few programs employ a psychiatrist on either a part-time or a full-time basis. After providing an overview of the need for, cost-effectiveness of, and current status of employee assistance programs, the authors draw on their own experiences with employee assistance programs to present four broad categories of roles the psychiatrist can assume in such programs: clinician, supervisor and educator, administrator, and organizational consultant. Problems encountered in these roles are also discussed.

  4. Overview of NRC PRA research program

    International Nuclear Information System (INIS)

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T.

    1997-01-01

    The NRC's research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements

  5. Heavy-Section Steel Technology program overview

    International Nuclear Information System (INIS)

    Pennell, W.E.

    1990-01-01

    This paper presents a status review of ongoing HSST program tasks aimed at refining the technology used in analysis of reactor pressure vessel fracture margins under pressurized thermal-shock (PTS) loading. Specific fracture-technology issues addressed include vessel flaw density and distribution, shallow flaws, fracture-toughness data transfer, circumferential cracks, ductile tearing and the influence of low-tearing toughness in stainless steel cladding. Preliminary results from the analysis and test programs are presented, together with interim assessments of their potential impact on a reactor vessel PTS analysis. 31 refs., 23 figs., 1 tab

  6. Overview of DOE's transuranic waste program

    International Nuclear Information System (INIS)

    McFadden, M.H.; Detamore, J.A.

    1988-01-01

    The United States Department of Energy (DOE) has assigned to Albuquerque Operations the Defense Transuranic Waste Program (DTWP) responsibility for long-range planning and management for defense transuranic (TRU) waste. The Transuranic Waste Lead Organization (TLO) has divided the Program into seven elements that support its primary goal of ending interim storage and achieving permanent disposal. These elements include waste generation site activities, storage site activities, burial site activities, technology development, transportation, institutional activities and permanent disposal. This paper briefly discusses these seven elements and how they are integrated to provide for successful achievement of the primary goal

  7. Overview of DOE's Transuranic Waste Program

    International Nuclear Information System (INIS)

    McFadden, M.H.; Detamore, J.A.

    1987-01-01

    The US Department of Energy has assigned to Albuquerque Operations the Defense Transuranic Waste Program responsibility for long-range planning and management of defense transuranic (TRU) waste. The Transuranic Waste Lead Organization (TLO) has divided the Program into seven elements which support it's primary goal of ending interim storage and achieving permanent disposal. These are: waste generation site activities, storage site activities, burial site activities, technology development, transportation, institutional activities, and permanent disposal. This paper will briefly discuss these seven elements and how they are integrated to provide for successful achievement of the primary goal

  8. OVERVIEW OF USEPA'S ARSENIC TECHNOLOGY DEMONSTRATION PROGRAM

    Science.gov (United States)

    This presentation provides a summary on the Arsenic Treatment Technology Demonstration Program. The information includes the history and the current status of the demonstration projects on both round 1 and round 2 including some photos of the treatment systems. The presentation m...

  9. Subseabed Disposal Program plan. Volume I. Overview

    International Nuclear Information System (INIS)

    1980-01-01

    Some of the most stable geologic formations are underneath the deep oceans. Purpose of this program is to assess the technical, environmental, and engineering feasibility of disposing of packaged high-level waste and/or repackaged spent reactor fuel in these formations

  10. Data systems and computer science programs: Overview

    Science.gov (United States)

    Smith, Paul H.; Hunter, Paul

    1991-01-01

    An external review of the Integrated Technology Plan for the Civil Space Program is presented. The topics are presented in viewgraph form and include the following: onboard memory and storage technology; advanced flight computers; special purpose flight processors; onboard networking and testbeds; information archive, access, and retrieval; visualization; neural networks; software engineering; and flight control and operations.

  11. Military Transition Assistance Program (TAP): An Overview

    Science.gov (United States)

    2017-03-15

    in the development, management oversight, and strategic planning of TAP. TAP Counseling Requirements Over time, Congress has increased the...training, and placement services provided under qualified job training programs of the DOL* Veterans small business ownership and entrepreneurship ...Accessing Higher Education (DOD) Career Technical Training (VA) Entrepreneurship (SBA) Capstone Verifies that servicemembers have met Career

  12. Subseabed Disposal Program Plan. Volume I. Overview

    International Nuclear Information System (INIS)

    1981-07-01

    The primary objective of the Subseabed Disposal Program (SDP) is to assess the scientific, environmental, and engineering feasibility of disposing of processed and packaged high-level nuclear waste in geologic formations beneath the world's oceans. High-level waste (HLW) is considered the most difficult of radioactive wastes to dispose of in oceanic geologic formations because of its heat and radiation output. From a scientific standpoint, the understanding developed for the disposal of such HLW can be used for other nuclear wastes (e.g., transuranic - TRU - or low-level) and materials from decommissioned facilities, since any set of barriers competent to contain the heat and radiation outputs of high-level waste will also contain such outputs from low-level waste. If subseabed disposal is found to be feasible for HLW, then other factors such as cost will become more important in considering subseabed emplacement for other nuclear wastes. A secondary objective of the SDP is to develop and maintain a capability to assess and cooperate with the seabed nuclear waste disposal programs of other nations. There are, of course, a number of nations with nuclear programs, and not all of these nations have convenient access to land-based repositories for nuclear waste. Many are attempting to develop legislative and scientific programs that will avoid potential hazards to man, threats to other ocean uses, and marine pollution, and they work together to such purpose in meetings of the international NEA/Seabed Working Group. The US SDP, as the first and most highly developed R and D program in the area, strongly influences the development of subseabed-disposal-related policy in such nations

  13. An overview of the ASCOT program

    International Nuclear Information System (INIS)

    Doran, J.C.

    1993-09-01

    ASCOT (Atmospheric Studies in Complex Terrain) is a multi-laboratory U.S. Department of Energy research program studying the properties of atmospheric boundary layers over non-uniform terrain and the interactions among various scales of motion that influence those properties. Within this context, one of the principal goals of the ASCOT program is to provide information necessary for an accurate description of transport and diffusion processes for atmosphere pollutants that may be released in regions of complex terrain. Three examples from past ASCOT research relevant to this goal are presented. Current and proposed research in the Front Range region of Colorado in the vicinity of the Rocky Flats Plant is also described

  14. Overview of ONWI'S Salt site selection program

    International Nuclear Information System (INIS)

    Madia, W.J.

    1983-01-01

    In the past year, activities in the salt site selection program of the Office of Nuclear Waste Isolation (ONWI) have focused on narrowing the number and size of areas under consideration as candidate repository sites. The progressive focusing is illustrated. Bedded salt, in the Permian Basin of West Texas and the Paradox Basin of Utah, and salt domes in the Gulf Coast Salt Dome Region (including parts of East Texas, Louisiana, and Mississippi) have been the subjects of geologic, environmental, and socioeconomic characterization of progressively greater detail as the screening process has proceeded. Detailed, field-oriented research and testing have superceded broad-based studies relying heavily on literature and other existing data. Coinciding with the increased field activities has been the publication of results and recommendations resulting from earlier program efforts

  15. Overview of Japanese control rods development program

    International Nuclear Information System (INIS)

    Koyama, M.

    1984-01-01

    The Japanese control rods development program was established based on the fast breeder reactor program. Therefore, PNC's efforts have been made mainly for the development of analysis, design and fabrication technologies for ''JOYO'' and ''MONJU'' control rods. Laboratory studies were performed to obtain the information for absorber materials. The design and fabrication of the sealed and vented type control rod pins were completed, and water loop tests and in-sodium tests were carried out. Irradiation behavior of enriched B 4 C pellets with low and high density in DFR was examined. Japan's experimental fast reactor, JOYO, has been operated at the rated power of 50MWt and 75MWt since April 1977 when the MK-I core (breeder core) attained initial criticality. Post irradiation examinations on control rod, removed from the reactor, were carried out and their performance behavior were evaluated. In the MK-II core, a control rods monitoring program has been in investigation. Absorber Materials Irradiation Rigs (AMIR) are scheduled to be loaded and irradiated in the JOYO MK-II core from 1984. (author)

  16. Photovoltaic Energy Program Overview, Fiscal Year 2000

    Energy Technology Data Exchange (ETDEWEB)

    Weis-Taylor, P.

    2001-03-02

    This ''annual report'' details the FY 2000 achievements of the U.S. Department of Energy PV Program in the categories of Research and Development, Technology Development, and Systems Engineering and Applications. Highlights include development of a record-breaking concentrator solar cell that is 32.4% efficient; fabrication of a record CIGS (copper indium gallium diselenide) cell at 18.8% efficiency; sharing an R and D 100 award with Siemens Solar Industries and the California Energy Commission for development and deployment of commercial CIS thin-film modules; and support for the efforts of the PV Industry Roadmap Workshop.

  17. An overview of the SAFSIM computer program

    International Nuclear Information System (INIS)

    Dobranich, D.

    1993-01-01

    SAFSIM (System Analysis Flow SIMulator) is a FORTRAN computer program that provides engineering simulations of user-specified flow networks at the system level. It includes fluid mechanics, heat transfer, and reactor dynamics capabilities. SAFSIM provides sufficient versatility to allow the simulation of almost any flow system, from a backyard sprinkler system to a clustered nuclear reactor propulsion system. In addition to versatility, speed and robustness are primary goals of SAFSIM development. The current capabilities of SAFSIM are summarized and some sample applications are presented. It is applied here to a nuclear thermal propulsion system and nuclear rocket engine test facility

  18. Efficient separations and processing crosscutting program overview

    Energy Technology Data Exchange (ETDEWEB)

    Gerdes, K.D. [Department of Energy, Germantown, MD (United States); Harness, J.L. [Department of Energy, Oak Ridge, TN (United States); Kuhn, W.L. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-10-01

    The US Department of Energy (DOE) established the Office of Science and Technology (formerly the Office of Technology Development), as part of the Office of Environmental Management (EM) in November 1989. EM manages remediation of all DOE sites and wastes from current operations. The goal of the EM program is to minimize risks to human health, safety, and the environment and to bring all DOE sites into compliance with federal, state, and local regulations by the year 2019. The Office of Science and Technology (EM-50) is charged with developing and implementing new technologies that are safer, faster, more effective, and less expensive than current methods. To focus resources and address opportunities, EM-50 has targeted four major remediation and waste management problem areas within the DOE complex for action based on risk, prevalence, or need for technology development to meet environmental requirements and regulations. Other areas may be added or current areas further partitioned to ensure that research technology development programs remain focused on EM`s most pressing remediation and waste management needs. These major problem areas, called Focus Areas are: high-level waste tank remediation; mixed waste characterization, treatment, and disposal; subsurface contaminants; and facility transitioning, decommissioning, and final disposition.

  19. Overview of the Tokamak de Varennes program

    International Nuclear Information System (INIS)

    Pacher, H.D.

    1986-01-01

    The Tokamak de Varennes will be the major Canadian experiment in the magnetic fusion domain. It has a toroidal field of 1.5 tesla, major radius of 0.85 m, a minor radius of 0.25 m, and will study long pulses, up to 30 seconds duration. Initially, a series of successive plasma pulses, each of the order of seconds, will yield a duty factor of over 50 percent. During this phase, the major emphasis will be on the study of impurity generation, transport, and control, plasma-wall interactions and material properties. The program will include studies of fast current rampdown and the resultant current profile modifications. The development of advanced diagnostics will also be undertaken. To attain a higher duty factor with continuous plasma operation, noninductive current drive by radio=frequency will be added as an early upgrade. This will introduce current drive investigations such as transformer recharge and profile relaxation, and enhance the wall and materials study program. In this context, the Tokamak de Varennes will concentrate on the study of impurity exhaust and retention as well as net erosion of the limiter and neutralization plate materials

  20. Overview of the USA inertial fusion program

    International Nuclear Information System (INIS)

    Kahalas, S.L.

    1989-01-01

    The next step in the USA inertial fusion program is to begin planning for a Laboratory Microfusion Facility or LMF. The LMF would have an output energy of between 200 and 1000 MJ, the latter energy being equivalent to a quarter ton of high explosive, with an input driver energy of 5-10 MJ. This implies a high target gain, 100-200 or more, with either a laser or particle beam driver. The LMF would cost a half billion to a billion dollars and would require a serious commitment by the country and the Department of Energy. The Department is in the stage of preliminary planning for an LMF and beginning a process by which a driver selection can be made in the fiscal year 1991-1992 timeframe. Construction initiation will require that a departmental decision be made as well as appropriation of funds within the Congressional funding cycle. In this paper, we review recent progress leading to the new USA program planning for the next facility and describe the status of this preliminary planning as well as characteristics of the LMF. (orig.)

  1. LLL magnetic fusion energy program: an overview

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    Over the last 12 months, significant progress has been made in the LLL magnetic fusion energy program. In the 2XIIB experiment, a tenfold improvement was achieved in the plasma confinement factor (the product of plasma density and confinement time), pushed plasma temperature and pressure to values never before reached in a magnetic fusion experiment, and demonstrated--for the first time--plasma startup by neutral beam injection. A new laser-pellet startup technique for Baseball IIT has been successfully tested and is now being incorporated in the experiment. Technological improvements have been realized, such as a breakthrough in fabricating niobium-tin conductors for superconducting magnets. These successes, together with complementary progress in theory and reactor design, have led to a proposal to build the MX facility, which could be on the threshold of a mirror fusion reactor

  2. Department of Energy Hazardous Waste Remedial Actions Program: An overview

    International Nuclear Information System (INIS)

    Eyman, L.D.; Swiger, R.F.

    1988-01-01

    This paper describes the national Department of Energy (DOE) program for managing hazardous waste. An overview of the DOE Hazardous Waste Remedial Actions Program (HAZWRAP), including its mission, organizational structure, and major program elements, is given. The paper focuses on the contractor support role assigned to Martin Marietta Energy Systems, Inc., through the establishment of the HAZWRAP Support Contractor Office (SCO). The major SCO programs are described, and the organization for managing the programs is discussed. The HAZWRAP SCO approaches to waste management planning and to technology research, development, and demonstration are presented. The role of the SCO in the DOE Environmental Restoration Program and the development of the DOE Waste Information network are reviewed. Also discussed is the DOE Work for Others Program, where waste management decentralized support, via interagency agreements between DOE and the Department of Defense and DOE and the Environmental Protection Agency, is provided for those sponsors planning remedial response actions. 2 refs

  3. Overview of NASA's Microgravity Materials Science Program

    Science.gov (United States)

    Downey, James Patton

    2012-01-01

    The microgravity materials program was nearly eliminated in the middle of the aughts due to budget constraints. Hardware developments were eliminated. Some investigators with experiments that could be performed using ISS partner hardware received continued funding. Partnerships were established between US investigators and ESA science teams for several investigations. ESA conducted peer reviews on the proposals of various science teams as part of an ESA AO process. Assuming he or she was part of a science team that was selected by the ESA process, a US investigator would submit a proposal to NASA for grant funding to support their part of the science team effort. In a similar manner, a US materials investigator (Dr. Rohit Trivedi) is working as a part of a CNES selected science team. As funding began to increase another seven materials investigators were selected in 2010 through an NRA mechanism to perform research related to development of Materials Science Research Rack investigations. One of these has since been converted to a Glovebox investigation.

  4. Overview of the RERF scientific research program

    International Nuclear Information System (INIS)

    Bennett, B.G.

    2003-01-01

    Radiation Effects Research Foundation (RERF) was founded to study the effects of radiation in survivors of the atomic bombings of Hiroshima and Nagasaki. Several fixed cohorts or sub-cohorts were established to provide epidemiological and clinical data on the health status and mortality of survivors and their children. Genetics and radiobiological studies are carried out to help interpret the findings. The Life Span Study is the core project of RERF. It consists of a large cohort from a general population of both sexes and all ages, encompassing a wide range of accurately known doses and incorporating accurate disease incidence and mortality recording. These features make this a very valuable and informative study. The Adult Health Study is a clinical study of a sub-cohort of the Life Span Study. Examinations of survivors are conducted every two years, providing a continuing health profile of an aging population and establishing the radiation-related risk of non-cancer diseases. The children of atomic-bomb survivors are being studied to determine whether genetic effects might be apparent that could be related to parental exposures. Initial study of post-natal defects did not demonstrate discernable effects. The mortality follow up is continuing. A new clinical study of survivor children was recently started to examine the health condition of these now middle-aged individuals. It is now 58 years since the atomic bombings of Hiroshima and Nagasaki. The legacy of those events still marks the lives of the survivors. RERF feels an important responsibility to investigate the effects of radiation to contribute to the welfare of those affected, to understand and quantify the effects, and to provide a scientific basis for radiation protection worldwide. We intend to continue a high quality scientific research program into the future, establishing where possible more collaborative efforts to be sure that our shared resources and capabilities are most effectively utilized

  5. Overview of the Novel Intelligent JAXA Active Rotor Program

    Science.gov (United States)

    Saito, Shigeru; Kobiki, Noboru; Tanabe, Yasutada; Johnson, Wayne; Yamauchi, Gloria K.; Young, Larry A.

    2010-01-01

    The Novel Intelligent JAXA Active Rotor (NINJA Rotor) program is a cooperative effort between JAXA and NASA, involving a test of a JAXA pressure-instrumented, active-flap rotor in the 40- by 80-Foot Wind Tunnel at Ames Research Center. The objectives of the program are to obtain an experimental database of a rotor with active flaps and blade pressure instrumentation, and to use that data to develop analyses to predict the aerodynamic and aeroacoustic performance of rotors with active flaps. An overview of the program is presented, including a description of the rotor and preliminary pretest calculations.

  6. Overview of Faculty Development Programs for Interprofessional Education.

    Science.gov (United States)

    Ratka, Anna; Zorek, Joseph A; Meyer, Susan M

    2017-06-01

    Objectives. To describe characteristics of faculty development programs designed to facilitate interprofessional education, and to compile recommendations for development, delivery, and assessment of such faculty development programs. Methods. MEDLINE, CINAHL, ERIC, and Web of Science databases were searched using three keywords: faculty development, interprofessional education, and health professions. Articles meeting inclusion criteria were analyzed for emergent themes, including program design, delivery, participants, resources, and assessment. Results. Seventeen articles were identified for inclusion, yielding five characteristics of a successful program: institutional support; objectives and outcomes based on interprofessional competencies; focus on consensus-building and group facilitation skills; flexibility based on institution- and participant-specific characteristics; and incorporation of an assessment strategy. Conclusion. The themes and characteristics identified in this literature overview may support development of faculty development programs for interprofessional education. An advanced evidence base for interprofessional education faculty development programs is needed.

  7. Overview of the Defense Programs Research and Technology Development Program for Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This documents presents a programmatic overview and program element plan summaries for conceptual design and assessment; physics; computation and modeling; system engineering science and technology; electronics, photonics, sensors, and mechanical components; chemistry and materials; special nuclear materials, tritium, and explosives.

  8. K-9 training aids made using additive manufacturing

    Science.gov (United States)

    Reynolds, John G.; Durban, Matthew M.; Gash, Alexander E.; Grapes, Michael D.; Kelley, Ryan S.; Sullivan, Kyle T.

    2018-02-20

    Additive Manufacturing (AM) is used to make aids that target the training of K-9s to detect explosives. The process uses mixtures of explosives and matrices commonly used in AM. The explosives are formulated into a mixture with the matrix and printed using AM techniques and equipment. The explosive concentrations are kept less than 10% by wt. of the mixture to conform to requirements of shipping and handling.

  9. Federal Energy Efficiency through Utility Partnerships: Federal Energy Management Program (FEMP) Program Overview Fact Sheet

    International Nuclear Information System (INIS)

    Beattie, D.; Wolfson, M.

    2001-01-01

    This Utility Program Overview describes how the Federal Energy Management Program (FEMP) utility program assists Federal energy managers. The document identifies both a utility financing mechanism and FEMP technical assistance available to support agencies' implementation of energy and water efficiency methods and renewable energy projects

  10. Overview of the US spent nuclear fuel program

    International Nuclear Information System (INIS)

    Hurt, W.L.

    1999-01-01

    This report, Overview of the United States Spent Nuclear Fuel Program, December, 1997, summarizes the U.S. strategy for interim management and ultimate disposition of spent nuclear fuel from research and test reactors. The key elements of this strategy include consolidation of this spent nuclear fuel at three sites, preparation of the fuel for geologic disposal in road-ready packages, and low-cost dry interim storage until the planned geologic repository is opened. The U.S. has a number of research programs in place that are intended to Provide data and technologies to support both characterization and disposition of the fuel. (author)

  11. Los Alamos safeguards program overview and NDA in safeguards

    International Nuclear Information System (INIS)

    Keepin, G.R.

    1988-01-01

    Over the years the Los Alamos safeguards program has developed, tested, and implemented a broad range of passive and active nondestructive analysis (NDA) instruments (based on gamma and x-ray detection and neutron counting) that are now widely employed in safeguarding nuclear materials of all forms. Here very briefly, the major categories of gamma ray and neutron based NDA techniques, give some representative examples of NDA instruments currently in use, and cite a few notable instances of state-of-the-art NDA technique development. Historical aspects and a broad overview of the safeguards program are also presented

  12. The experiments of high power electron beam emission by the K-9M-57 and K-9M-58 rockets

    International Nuclear Information System (INIS)

    Kaneko, Osamu; Sasaki, Susumu; Yamori, Akira; Hagiwara, Michinobu; Kawashima, Nobuki

    1977-01-01

    Active experiments have been conducted to obtain the precise picture of the ionosphere and magnetosphere. As the turbulence source of the active experiment by the authors, electron beam was employed, and the variation of the rocket potential, wave excitation and turbulence of peripheral plasma were investigated. The rated voltage and current of the present electron gun were 6 kV and 500 mA, respectively. The Langmuir probe, floating probe, optical detector and wave receiver were used for the measurement of various phenomena associated with electron beam emission. The experimental data on the voltage-current characteristics of the electron gun, the rocket potential, total light emission and plasma density and temperature were obtained by the K-9M-57 and K-9M-58 rockets. (Yoshimori, M.)

  13. Low-level waste management program: technical program overview

    International Nuclear Information System (INIS)

    Lowrie, R.S.

    1981-01-01

    The mission of the technical program is to develop the technology component of the Department of Energy's Low-Level Waste Management Program and to manage research and development, demonstration, and documentation of the technical aspects of the program. Some of the major technology objectives are: develop and demonstrate techniques for waste generation reduction; develop and demonstrate waste treatment, handling and packaging techniques; develop and demonstrate the technology for greater confinement; and develop the technology for remedial action at existing sites. In addition there is the technology transfer objective which is to compile and issue a handbook documenting the technology for each of the above technology objectives

  14. Overview of AEOD's program for trending reactor operational events

    International Nuclear Information System (INIS)

    Baranowsky, P.W.; O'Reilly, P.D.; Rasmuson, D.M.; Houghton, J.R.

    1994-01-01

    This paper presents an overview of the trending program being performed by AEOD. The major elements of the program include: (1) system and component reliability trending and analysis, (2) special data collection and analysis (e.g., IPE and PRA component failure data, common cause failure event data), (3) risk assessment of safety issues based on actual operating experience, (4) Accident Sequence Precursor (ASP) Program, and (5) trending US industry risk. AEOD plans to maintain up-to-date safety data trends for selected high risk or high regulatory profile components, systems, accident initiators, accident sequences, and regulatory issues. AEOD will also make greater use of PRA insights and perform limited probabilistic safety assessments to evaluate the safety significance of qualitative results. Examples of a system study and an issue evaluation are presented, as well as a summary of the common cause failure event database

  15. Graphic overview system for DOE's effluent and environmental monitoring programs

    International Nuclear Information System (INIS)

    Burson, Z.G.; Elle, D.R.

    1980-03-01

    The Graphic Overview System is a compilation of photos, maps, overlays, and summary information of environmental programs and related data for each DOE site. The information consists of liquid and airborne effluent release points, on-site storage locations, monitoring locations, aerial survey results, population distributions, wind roses, and other related information. The relationships of different environmental programs are visualized through the use of colored overlays. Trends in monitoring data, effluent releases, and on-site storage data are also provided as a corollary to the graphic display of monitoring and release points. The results provide a working tool with which DOE management (headquarters and field offices) can place in proper perspective key aspects of all environmental programs and related data, and the resulting public impact of each DOE site

  16. An overview of the Cooperative IASCC Research (CIR) program

    International Nuclear Information System (INIS)

    Pathania, R.; Gott, K.; Scott, P.

    2007-01-01

    Irradiation-Assisted Stress Corrosion Cracking (IASCC) has affected reactor core internal structures fabricated from austenitic stainless steels in both Pressurized Water Reactors (PWR) and Boiling Water Reactors (BWR). The Cooperative IASCC Research (CIR) Program is an international research effort designed to address irradiation-assisted stress corrosion cracking (IASCC) in light water reactor (LWR) components. The objectives of the CIR program are to develop a mechanistic understanding of IASCC initiation and crack growth, to derive a predictive model of IASCC, if possible based on a mechanistic understanding, and thus to identify possible countermeasures to IASCC. It complements other more applied programs by concentrating on the underlying physical causes of IASCC. This paper provides an overview of the current status and achievements of the CIR program, which has been running since 1995. Two phases of the program have been completed and a final extension program is in progress which is scheduled to finish in 2008. The extent to which the CIR program has met its objectives, or will meet them with its current plans extending into 2008, is assessed. (author)

  17. An Overview of Residential Ventilation Activities in the Building America Program (Phase I)

    Energy Technology Data Exchange (ETDEWEB)

    Barley, D.

    2001-05-21

    This report provides an overview of issues involved in residential ventilation; provides an overview of the various ventilation strategies being evaluated by the five teams, or consortia, currently involved in the Building America Program; and identifies unresolved technical issues.

  18. An overview of the NASA rotary engine research program

    Science.gov (United States)

    Meng, P. R.; Hady, W. F.

    1984-01-01

    A brief overview and technical highlights of the research efforts and studies on rotary engines over the last several years at the NASA Lewis Research Center are presented. The test results obtained from turbocharged rotary engines and preliminary results from a high performance single rotor engine were discussed. Combustion modeling studies of the rotary engine and the use of a Laser Doppler Velocimeter to confirm the studies were examined. An in-house program in which a turbocharged rotary engine was installed in a Cessna Skymaster for ground test studies was reviewed. Details are presented on single rotor stratified charge rotary engine research efforts, both in-house and on contract.

  19. Philosophy and overview of the INEL waste management program

    International Nuclear Information System (INIS)

    Gertz, C.P.; Whitsett, J.B.; Hamric, J.P.

    1986-01-01

    The INEL philosophy of ''get the job done; do it right--the first time'' is described as it applies to all phases of waste management activities. In addition, an overview of INEL's waste management programs and projects--low-level waste management operations and technology development; transuranic waste management operations and technology development; high-level waste management operations and technology development; spent fuel storage operations and equipment/technology development; transportation operations, technology development, and prototype cask procurements--are discussed. Emphasis is placed on the application of the INEL philosophy to the successful initiation and continuation of INEL waste management activities

  20. Overview: Defense high-level waste technology program

    International Nuclear Information System (INIS)

    Shupe, M.W.; Turner, D.A.

    1987-01-01

    Defense high-level waste generated by atomic energy defense activities is stored on an interim basis at three U.S. Department of Energy (DOE) operating locations; the Savannah River Plant in South Carolina, the Hanford Site in Washington, and the Idaho National Engineering Laboratory in Idaho. Responsibility for the permanent disposal of this waste resides with DOE's Office of Defense Waste and Transportation Management. The objective of the Defense High-Level Wast Technology Program is to develop the technology for ending interim storage and achieving permanent disposal of all U.S. defense high-level waste. New and readily retrievable high-level waste are immobilized for disposal in a geologic repository. Other high-level waste will be stabilized in-place if, after completion of the National Environmental Policy Act (NEPA) process, it is determined, on a site-specific basis, that this option is safe, cost effective and environmentally sound. The immediate program focus is on implementing the waste disposal strategy selected in compliance with the NEPA process at Savannah River, while continuing progress toward development of final waste disposal strategies at Hanford and Idaho. This paper presents an overview of the technology development program which supports these waste management activities and an assessment of the impact that recent and anticipated legal and institutional developments are expected to have on the program

  1. U.S. DOE indirect coal liquefaction program: An overview

    Energy Technology Data Exchange (ETDEWEB)

    Shen, J.; Schmetz, E.; Winslow, J.; Tischer, R. [Dept. of Energy, Germantown, MD (United States); Srivastava, R.

    1997-12-31

    Coal is the most abundant domestic energy resource in the United States. The Fossil Energy Organization within the US Department of Energy (DOE) has been supporting a coal liquefaction program to develop improved technologies to convert coal to clean and cost-effective liquid fuels to complement the dwindling supply of domestic petroleum crude. The goal of this program is to produce coal liquids that are competitive with crude at $20 to $25 per barrel. Indirect and direct liquefaction routes are the two technologies being pursued under the DOE coal liquefaction program. This paper will give an overview of the DOE indirect liquefaction program. More detailed discussions will be given to the F-T diesel and DME fuels which have shown great promises as clean burning alternative diesel fuels. The authors also will briefly discuss the economics of indirect liquefaction and the hurdles and opportunities for the early commercial deployment of these technologies. Discussions will be preceded by two brief reviews on the liquid versus gas phase reactors and the natural gas versus coal based indirect liquefaction.

  2. The NASA Electronic Parts and Packaging (NEPP) Program: An Overview

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2016-01-01

    This presentation provides an overview of the NEPP Program. The NEPP Mission is to provide guidance to NASA for the selection and application of microelectronics technologies; Improve understanding of the risks related to the use of these technologies in the space environment; Ensure that appropriate research is performed to meet NASA mission assurance needs. NEPP's Goals are to provide customers with appropriate and cost-effective risk knowledge to aid in: Selection and application of microelectronics technologies; Improved understanding of risks related to the use of these technologies in the space environment; Appropriate evaluations to meet NASA mission assurance needs; Guidelines for test and application of parts technologies in space; Assurance infrastructure and support for technologies in use by NASA space systems.

  3. An overview of the Radioisotope Thermoelectric Generator Transportation System Program

    International Nuclear Information System (INIS)

    McCoy, J.C.; Becker, D.L.

    1996-01-01

    Radioisotope Thermoelectric Generators (RTG) convert the heat generated by radioactive decay to electricity using thermocouples. RTGs have a long operating life, are reasonably lightweight, and require little or no maintenance once assembled and tested. These factors make RTGs particularly attractive for use in spacecraft. However, because RTGs contain significant quantities of radioactive materials, normally plutonium-238 and its decay products, they must be transported in packages built in accordance with Title 10, Code of Federal Regulations, Part 71. The U.S. Department of Energy assigned the Radioisotope Thermoelectric Generator Transportation System (RTGTS) Program to Westinghouse Hanford Company in 1988 to develop a system meeting the regulatory requirements. The program objective was to develop a transportation system that would fully comply with 10 CFR 71 while protecting RTGs from adverse environmental conditions during normal conditions of transport (e.g., shock and heat). The RTGTS is scheduled for completion in December 1996 and will be available to support the National Aeronautics and Space Administration close-quote s Cassini mission to Saturn in October 1997. This paper provides an overview of the RTGTS and discusses the hardware being produced. Additionally, various program management innovations mandated by recent major changes in the U.S. Department of Energy structure and resources will be outlined. copyright 1996 American Institute of Physics

  4. Physics of the Cosmos (PCOS) Technology Development Program Overview

    Science.gov (United States)

    Pham, B. Thai; Clampin, M.; Werneth, R. L.

    2014-01-01

    The Physics of the Cosmos (PCOS) Program Office was established in FY11 and resides at the NASA Goddard Space Flight Center (GSFC). The office serves as the implementation arm for the Astrophysics Division at NASA Headquarters for PCOS Program related matters. We present an overview of the Program’s technology management activities and the Program’s technology development portfolio. We discuss the process for addressing community-provided technology needs and the Technology Management Board (TMB)-vetted prioritization and investment recommendations. This process improves the transparency and relevance of technology investments, provides the community a voice in the process, and leverages the technology investments of external organizations by defining a need and a customer. Goals for the PCOS Program envisioned by the National Research Council’s (NRC) “New Worlds, New Horizons in Astronomy and Astrophysics” (NWNH) Decadal Survey report include science missions and technology development for dark energy, gravitational waves, X-ray, and inflation probe science.

  5. An overview of the Radioisotope Thermoelectric Generator Transporation System Program

    International Nuclear Information System (INIS)

    McCoy, J.C.

    1995-10-01

    Radioisotope Thermoelectric Generators (RTG) convert the heat generated by radioactive decay to electricity using thermocouples. RTGs have a long operating life, are reasonably lightweight, and require little or no maintenance once assembled and tested. These factors make RTGs particularly attractive for use in spacecraft However, because RTGs contain significant quantities of radioactive materials, normally plutonium-238 and its decay products, they must be transported in packages built in accordance with Title 10, Code of Federal Regulations, Part 71. The US Department of Energy assigned the Radioisotope Thermoelectric Generator Transportation System (RTGTS) Program to Westinghouse Hanford Company in 1988 to develop a system meeting the regulatory requirements. The program objective was to develop a transportation system that would fully comply with 10 CFR 71 while protecting RTGs from adverse environmental conditions during normal conditions of transport (e.g., shock and heat). The RTGTS is scheduled for completion in December 1996 and will be available to support the National Aeronautics and Space Administrations Cassini mission to Saturn in October 1997. This paper provides an overview of the RTGTS and discusses the hardware being produced. Additionally, various program management innovations mandated by recent ma or changes in the US Department of Energy structure and resources will be outlined

  6. Overview of the DOE-EM Packaging Certification Program

    International Nuclear Information System (INIS)

    Feldman, M.R.; Bennett, M.E.; Shuler, J.M.

    2009-01-01

    The U.S. Department of Transportation, in 49 CFR 173.7(d) grants the U.S. Department of Energy (DOE) the power to use 'packagings made by or under the direction of the U.S. Department of Energy... for the transportation of Class 7 materials when evaluated, approved and certified by the Department of Energy against packaging standards equivalent to those specified in 10 CFR part 71'. Via DOE Order 460.1B, DOE has established the DOE Packaging Certification Program (PCP) within the Department of Environmental Management for purposes including the certification of radioactive materials packages for DOE use. This paper will provide an overview of the programs and activities currently undertaken by the PCP in support of the safe transport of radioactive materials, including technical review of Safety Analysis Reports for Packaging, development of guidance documents and training courses, a quality assurance audit and field assessment program, database and docket management, and testing and test methodology development. The paper will also highlight the various organizations currently utilized by the PCP to meet the requirements of DOE O 460.1B, as well as some creative and effective methods that are being used to meet program objectives. The DOE Package Certification Program's primary function is to perform technical reviews of SARPs in support of the packaging certification process to ensure that the maximum protection is afforded to the public, all federal regulations are met, and the process is as time-effective and cost-effective as possible. Five additional specific functions are also supported by the PCP: development of guidance documents, training courses, a QA audit and field assessment program, database and docket management, and testing methods development. Each of these functions individually contributes to the overall mission of the PCP as defined in DOE O 460.1B. Taken as a whole, these functions represent a robust program to ensure the safety of workers

  7. Overview of the DIII-D program computer systems

    International Nuclear Information System (INIS)

    McHarg, B.B. Jr.

    1997-11-01

    Computer systems pervade every aspect of the DIII-D National Fusion Research program. This includes real-time systems acquiring experimental data from data acquisition hardware; cpu server systems performing short term and long term data analysis; desktop activities such as word processing, spreadsheets, and scientific paper publication; and systems providing mechanisms for remote collaboration. The DIII-D network ties all of these systems together and connects to the ESNET wide area network. This paper will give an overview of these systems, including their purposes and functionality and how they connect to other systems. Computer systems include seven different types of UNIX systems (HP-UX, REALIX, SunOS, Solaris, Digital UNIX, Ultrix, and IRIX), OpenVMS systems (both BAX and Alpha), MACintosh, Windows 95, and more recently Windows NT systems. Most of the network internally is ethernet with some use of FDDI. A T3 link connects to ESNET and thus to the Internet. Recent upgrades to the network have notably improved its efficiency, but the demand for bandwidth is ever increasing. By means of software and mechanisms still in development, computer systems at remote sites are playing an increasing role both in accessing and analyzing data and even participating in certain controlling aspects for the experiment. The advent of audio/video over the interest is now presenting a new means for remote sites to participate in the DIII-D program

  8. An overview of solution methods for multi-objective mixed integer linear programming programs

    DEFF Research Database (Denmark)

    Andersen, Kim Allan; Stidsen, Thomas Riis

    Multiple objective mixed integer linear programming (MOMIP) problems are notoriously hard to solve to optimality, i.e. finding the complete set of non-dominated solutions. We will give an overview of existing methods. Among those are interactive methods, the two phases method and enumeration...... methods. In particular we will discuss the existing branch and bound approaches for solving multiple objective integer programming problems. Despite the fact that branch and bound methods has been applied successfully to integer programming problems with one criterion only a few attempts has been made...

  9. Nevada Nuclear Waste Storage Investigations Quality-Assurance Program Plan: management and overview

    International Nuclear Information System (INIS)

    1981-10-01

    This Quality Assurance Program Plan (QAPP) defines the quality assurance program in effect for those activities of the Nevada Nuclear Waste Storage (NNWSI) that are directly controlled by: DOE/NV, the Technical Overview Contractor, and the Quality Assurance Overview Contractor. It is intended as a supplement to the NNWSI-QAP

  10. Overview of the U.S. Department of Energy's Isotope Programs

    International Nuclear Information System (INIS)

    Carty, J.

    2004-01-01

    This presentation provides an overview of the U.S. Department of Energy's Isotopes Program. The charter of the Isotope Programs covers the production and sale of radioactive and stable isotopes, associated byproducts, surplus materials, and related isotope services

  11. Brazilian Air Force aircraft structural integrity program: An overview

    Directory of Open Access Journals (Sweden)

    Alberto W. S. Mello Junior

    2009-01-01

    Full Text Available This paper presents an overview of the activities developed by the Structural Integrity Group at the Institute of Aeronautics and Space - IAE, Brazil, as well as the status of ongoing work related to the life extension program for aircraft operated by the Brazilian Air Force BAF. The first BAF-operated airplane to undergo a DTA-based life extension was the F-5 fighter, in the mid 1990s. From 1998 to 2001, BAF worked on a life extension project for the BAF AT- 26 Xavante trainer. All analysis and tests were performed at IAE. The fatigue critical locations (FCLs were presumed based upon structural design and maintenance data and also from exchange of technical information with other users of the airplane around the world. Following that work, BAF started in 2002 the extension of the operational life of the BAF T-25 “Universal”. The T-25 is the basic training airplane used by AFA - The Brazilian Air Force Academy. This airplane was also designed under the “safe-life” concept. As the T-25 fleet approached its service life limit, the Brazilian Air Force was questioning whether it could be kept in flight safely. The answer came through an extensive Damage Tolerance Analysis (DTA program, briefly described in this paper. The current work on aircraft structural integrity is being performed for the BAF F-5 E/F that underwent an avionics and weapons system upgrade. Along with the increase in weight, new configurations and mission profiles were established. Again, a DTA program was proposed to be carried out in order to establish the reliability of the upgraded F-5 fleet. As a result of all the work described, the BAF has not reported any accident due to structural failure on aircraft submitted to Damage Tolerance Analysis.

  12. Overview of recent focussing horns for the BNL neutrino program

    International Nuclear Information System (INIS)

    Carroll, A.; Leonhardt, W.; Monaghan, R.

    1987-01-01

    In this paper we present an overview of the two magnetic focussing horn systems recently constructed, installed, and operated in the fast extracted beam for the neutrino physics program at the AGS. These horn systems consist of a number of interrelated subsystems which operate together to produce a very intense, parallel beam of pions. The strong magnetic focussing is generated by pulsing the coaxial structures of the horns with currents of up to 300kA during the 2.5 μsec proton beam spill. Because of their high levels of induced radioactivity, these horns had to be designed for reliability and ease in installation. Both horn systems built had the same overall features, but the broad band system focussed pions over as large a momentum band as possible to maximize the neutrino flux. The narrow band systems restricted the momentum to +-15% of 3 GeV/c to provide kinematic constraints for the experiment. A synopsis of the design concepts and critical engineering requirements is given. Detailed discussion of the subsystems follows in the subsequent papers

  13. Live imaging of H3K9 acetylation in plant cells

    Science.gov (United States)

    Kurita, Kazuki; Sakamoto, Takuya; Yagi, Noriyoshi; Sakamoto, Yuki; Ito, Akihiro; Nishino, Norikazu; Sako, Kaori; Yoshida, Minoru; Kimura, Hiroshi; Seki, Motoaki; Matsunaga, Sachihiro

    2017-01-01

    Proper regulation of histone acetylation is important in development and cellular responses to environmental stimuli. However, the dynamics of histone acetylation at the single-cell level remains poorly understood. Here we established a transgenic plant cell line to track histone H3 lysine 9 acetylation (H3K9ac) with a modification-specific intracellular antibody (mintbody). The H3K9ac-specific mintbody fused to the enhanced green fluorescent protein (H3K9ac-mintbody-GFP) was introduced into tobacco BY-2 cells. We successfully demonstrated that H3K9ac-mintbody-GFP interacted with H3K9ac in vivo. The ratio of nuclear/cytoplasmic H3K9ac-mintbody-GFP detected in quantitative analysis reflected the endogenous H3K9ac levels. Under chemically induced hyperacetylation conditions with histone deacetylase inhibitors including trichostatin A, Ky-2 and Ky-14, significant enhancement of H3K9ac was detected by H3K9ac-mintbody-GFP dependent on the strength of inhibitors. Conversely, treatment with a histone acetyltransferase inhibitor, C646 caused a reduction in the nuclear to cytoplasmic ratio of H3K9ac-mintbody-GFP. Using this system, we assessed the environmental responses of H3K9ac and found that cold and salt stresses enhanced H3K9ac in tobacco BY-2 cells. In addition, a combination of H3K9ac-mintbody-GFP with 5-ethynyl-2′-deoxyuridine labelling confirmed that H3K9ac level is constant during interphase. PMID:28418019

  14. An Overview of the CNES Propulsion Program for Spacecraft

    Science.gov (United States)

    Cadiou, A.; Darnon, F.; Gibek, I.; Jolivet, L.; Pillet, N.

    2004-10-01

    This paper presents an overview of the CNES spacecraft propulsion activities. The main existing and future projects corresponding to low earth orbit and geostationary platforms are described. These projects cover various types of propulsion subsystems: monopropellant, bipropellant and electric. Monopropellant is mainly used for low earth orbit applications such as earth observation (SPOT/Helios, PLEIADES) or scientific applications (minisatellite PROTEUS line and micro satellites MYRIADE line). Bipropellant is used for geostationary telecommunications satellites (@BUS). The field of application of electric propulsion is the station keeping of geostationary telecommunication satellites (@BUS), main propulsion for specific probes (SMART 1) and fine attitude control for dedicated micro satellites (MICROSCOPE). The preparation of the future and the associated Research and Technology program are also described in the paper. The future developments are mainly dedicated to the performance improvements of electric propulsion which leads to the development of thrusters with higher thrust and higher specific impulse than those existing today, the evaluation of the different low thrust technologies for formation flying applications, the development of new systems to pressurize the propellants (volatile liquid, micro pump), the research on green propellants and different actions concerning components such as over wrapped pressure vessels, valves, micro propulsion. A constant effort is also put on plume effect in chemical and electrical propulsion area (improvement of tools and test activities) in the continuity of the previous work. These different R &T activities are described in detail after a presentation of the different projects and of their propulsion subsystems. The scientific activity supporting the development of Hall thrusters is going on in the frame of the GDR (Groupement de Recherche) CNRS / Universities / CNES / SNECMA on Plasma Propulsion.

  15. The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Silje V Veiseth

    2011-03-01

    Full Text Available Chromatin structure and gene expression are regulated by posttranslational modifications (PTMs on the N-terminal tails of histones. Mono-, di-, or trimethylation of lysine residues by histone lysine methyltransferases (HKMTases can have activating or repressive functions depending on the position and context of the modified lysine. In Arabidopsis, trimethylation of lysine 9 on histone H3 (H3K9me3 is mainly associated with euchromatin and transcribed genes, although low levels of this mark are also detected at transposons and repeat sequences. Besides the evolutionarily conserved SET domain which is responsible for enzyme activity, most HKMTases also contain additional domains which enable them to respond to other PTMs or cellular signals. Here we show that the N-terminal WIYLD domain of the Arabidopsis SUVR4 HKMTase binds ubiquitin and that the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin, enabling conversion of H3K9me1 to H3K9me3 in vitro. Chromatin immunoprecipitation and immunocytological analysis showed that SUVR4 in vivo specifically converts H3K9me1 to H3K9me3 at transposons and pseudogenes and has a locus-specific repressive effect on the expression of such elements. Bisulfite sequencing indicates that this repression involves both DNA methylation-dependent and -independent mechanisms. Transcribed genes with high endogenous levels of H3K4me3, H3K9me3, and H2Bub1, but low H3K9me1, are generally unaffected by SUVR4 activity. Our results imply that SUVR4 is involved in the epigenetic defense mechanism by trimethylating H3K9 to suppress potentially harmful transposon activity.

  16. 75 FR 13740 - Office of Innovation and Improvement; Overview Information; Charter Schools Program (CSP) Grants...

    Science.gov (United States)

    2010-03-23

    ... DEPARTMENT OF EDUCATION Office of Innovation and Improvement; Overview Information; Charter Schools Program (CSP) Grants for National Leadership Activities; Notice Inviting Applications for New... of public schools have been identified for improvement, corrective action, or restructuring under...

  17. 75 FR 37771 - Office of Postsecondary Education; Overview Information; Transition Programs for Students with...

    Science.gov (United States)

    2010-06-30

    ... education (or consortia of institutions of higher education), to create or expand high quality, inclusive... DEPARTMENT OF EDUCATION Office of Postsecondary Education; Overview Information; Transition Programs for Students with Intellectual Disabilities Into Higher Education (TPSID)--Model Comprehensive...

  18. Whole-House Approach Benefits Builders, Buyers, and the Environment Building America Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-05-01

    This document provides an overview of the U.S. Department of Energy's Building America program. Building America works with the residential building industry to develop and implement innovative building processes and technologies.

  19. Overview of the CTR blanket engineering research program at the University of Tokyo

    International Nuclear Information System (INIS)

    Nakazawa, Masaharu; Madarame, Haruki; Takahashi, Yoichi; Takagi, Toshiyuki

    1989-01-01

    A small overview has been given on the fusion reactor blanket engineering research program at the University of Tokyo as an introduction to the following articles, especially in its history, organization, experimental facilities and ten years research activity. (orig.)

  20. Overview

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This section describes the activities and accomplishments of the DOE research and development program offices. The Office of Energy Research (ER) manages fundamental science and basic energy research programs in several areas: high-energy physics; nuclear physics; the physical, biological, and mathematical sciences; magnetic fusion energy; and environmental and health effects. ER also supports many scientific user facilities that are used by universities and private-sector researchers and manages the DOE Small Business Innovation Research (SBIR) program and the R ampersand D Laboratory Technology Transfer Program. Brief descriptions of technology transfer accomplishments in each of these areas are given

  1. Nye County, Nevada 1992 nuclear waste repository program: Program overview. Final report

    International Nuclear Information System (INIS)

    1998-01-01

    The purpose of this document is to provide an overview of the Nye County FY92 Nuclear Waste Repository Program (Program). Funds to pay for Program costs will come from the Federal Nuclear Waste Fund, which was established under the Nuclear Waste Policy Act of 1982 (NWPA). In early 1983, the Yucca Mountain was identified as a potentially suitable site for the nation's first geologic repository for spent reactor fuel and high-level radioactive waste. Later that year, the Nye County Board of County Commissioners (Board) established the capability to monitor the Federal effort to implement the NWPA and evaluate the potential impacts of repository-related activities on Nye County. Over the last eight years, the County's program has grown in complexity and cost in order to address DOE's evolving site characterization studies, and prepare for the potential for facility construction and operation. Changes were necessary as well, in response to Congress's redirection of the repository program specified in the amendments, to the NWPA approved in 1987. In early FY 1991, the County formally established a project office to plan and implement its program of work. The Repository Project Office's (RPO) mission and functions are provided in Section 2.0. The RPO organization structure is described in Section 3.0

  2. Covalent Modifications of Histone H3K9 Promote Binding of CHD3

    Directory of Open Access Journals (Sweden)

    Adam H. Tencer

    2017-10-01

    Full Text Available Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD. Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3 whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9—methylation or acetylation (H3K9me3 or H3K9ac—enhance this interaction. Binding of CHD3 PHDs promotes H3K9Cme3-nucleosome unwrapping in vitro and perturbs the pericentric heterochromatin structure in vivo. Methylation or acetylation of H3K9 uniquely alleviates the intra-nucleosomal interaction of histone H3 tails, increasing H3K9 accessibility. Collectively, our data suggest that the targeting of covalently modified H3K9 by CHD3 might be essential in diverse functions of NuRD.

  3. An Overview of Quality Programs that Support Transition-Aged Youth

    Directory of Open Access Journals (Sweden)

    Christopher M. Kalinyak

    2016-12-01

    Full Text Available This article provides a concise overview of several programs that deliver services to transition-aged youth, ages 14–29. Included are family support, the Assisting Unaccompanied Children and Youth program, the Substance Abuse and Mental Health Services Administration services, the wraparound approach, intensive home-based treatment, multisystemic therapy, foster care, independent living, mentoring, the Steps to Success program, the Jump on Board for Success program, the Options program, the Positive Action program, the Transition to Success model, and the Transition to Independence Program. Primary focus is placed upon the usefulness of each of the programs in facilitating successful outcomes for transition-aged youth.

  4. Overview of national bird population monitoring programs and databases

    Science.gov (United States)

    Gregory S. Butcher; Bruce Peterjohn; C. John Ralph

    1993-01-01

    A number of programs have been set up to monitor populations of nongame migratory birds. We review these programs and their purposes and provide information on obtaining data or results from these programs. In addition, we review recommendations for improving these programs.

  5. Biogeochemistry of uranium mill wastes program overview and conclusions

    International Nuclear Information System (INIS)

    Dreesen, D.R.

    1981-05-01

    The major findings and conclusions are summarized for research on uranium mill tailings for the US Department of Energy and the US Nuclear Regulatory Commission. An overview of results and interpretations is presented for investigations of 222 Rn emissions, revegetation of tailings and mine spoils, and trace element enrichment, mobility, and bioavailability. A brief discussion addresses the implications of these findings in relation to tailings disposal technology and proposed uranium recovery processes

  6. The NASA Electronic Parts and Packaging (NEPP) Program: Overview and Update FY15 and Beyond

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2016-01-01

    The NASA Electronic Parts and Packaging (NEPP) program, and its subset the NASA Electronic Parts Assurance Group (NEPAG), are NASA's point-of-contacts for reliability and radiation tolerance of electrical, electronic, and electromechanical (EEE) parts and their packages. This presentation includes a Fiscal Year 2015 program overview.

  7. Encendiendo una Llama. Bilingual Gifted and Talented Program: Overview, Identification of Students, and Instructional Approaches.

    Science.gov (United States)

    Hartford Public Schools, CT.

    Three pamphlets describe facets of "Encendiendo Una Llama," a Hartford (Connecticut) demonstration program for bilingual gifted and talented students. An overview pamphlet summarizes key aspects of the model program: identification procedures, instructional services, teacher training, parent involvement, evidence of effectiveness, implementation…

  8. Reducing the Risk: Unemployed Migrant Youth and Labour Market Programs. Overview.

    Science.gov (United States)

    Australian Inst. of Multicultural Affairs, Melbourne (Australia).

    This booklet is an overview and summary of the publication "Reducing the Risk: Unemployed Migrant Youth and Labour Market Programs" which reviews programs and services for migrant and refugee youth in Australia. The unemployment rate for this group is higher than for their Australian-born peers, and their participation in governmental…

  9. Human Research Program Science Management: Overview of Research and Development Activities

    Science.gov (United States)

    Charles, John B.

    2007-01-01

    An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

  10. Overview of the U.S. Department of Energy's Isotope Programs

    Energy Technology Data Exchange (ETDEWEB)

    Carty, J.

    2004-10-05

    This presentation provides an overview of the U.S. Department of Energy's Isotopes Program. The charter of the Isotope Programs covers the production and sale of radioactive and stable isotopes, associated byproducts, surplus materials, and related isotope services.

  11. Overview of four prescription monitoring/review programs in Canada.

    Science.gov (United States)

    Furlan, Andrea D; MacDougall, Peter; Pellerin, Denise; Shaw, Karen; Spitzig, Doug; Wilson, Galt; Wright, Janet

    2014-01-01

    Prescription monitoring or review programs collect information about prescription and dispensing of controlled substances for the purposes of monitoring, analysis and education. In Canada, it is the responsibility of the provincial institutions to organize, maintain and run such programs. To describe the characteristics of four provincial programs that have been in place for >6 years. The managers of the prescription monitoring⁄review programs of four provinces (British Columbia, Alberta, Saskatchewan and Nova Scotia) were invited to present at a symposium at the Canadian Pain Society in May 2012. In preparation for the symposium, one author collected and summarized the information. Three provinces have a mix of review and monitoring programs; the program in British Columbia is purely for review and education. All programs include controlled substances (narcotics, barbiturates and psychostimulants); however, other substances are differentially included among the programs: anabolic steroids are included in Saskatchewan and Nova Scotia; and cannabinoids are included in British Columbia and Nova Scotia. Access to the database is available to pharmacists in all provinces. Physicians need consent from patients in British Columbia, and only professionals registered with the program can access the database in Alberta. The definition of inappropriate prescribing and dispensing is not uniform. Double doctoring, double pharmacy and high-volume dispensing are considered to be red flags in all programs. There is variability among Canadian provinces in managing prescription monitoring⁄review programs.

  12. Transcriptional repression is epigenetically marked by H3K9 methylation during SV40 replication

    OpenAIRE

    Kallestad, Les; Christensen, Kendra; Woods, Emily; Milavetz, Barry

    2014-01-01

    Background We have recently shown that T-antigen binding to Site I results in the replication-dependent introduction of H3K9me1 into SV40 chromatin late in infection. Since H3K9me2 and H3K9me3 are also present late in infection, we determined whether their presence was also related to the status of ongoing transcription and replication. Transcription was either inhibited with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidizole (DRB) or stimulated with sodium butyrate and the effects on histone m...

  13. Lawrence Berkeley Laboratory/University of California lighting program overview

    Energy Technology Data Exchange (ETDEWEB)

    Berman, S.

    1981-12-01

    The objective of the Lighting Program is to assist and work in concert with the lighting community (composed of manufacturers, designers, and users) to achieve a more efficient lighting economy. To implement its objectives, the Lighting Program has been divided into three major categories: technical engineering, buildings applications, and human impacts (impacts on health and vision). The technical program aims to undertake research and development projects that are both long-range and high-risk and which the lighting industry has little interest in pursuing on its own, but from which significant benefits could accrue to both the public and the industry. The building applications program studies the effects that introducing daylighting in commercial buildings has on lighting and cooling electrical energy requirements as well as on peak demand. This program also examines optimization strategies for integrating energy-efficient design, lighting hardware, daylighting, and overall building energy requirements. The impacts program examines relationships between the user and the physical lighting environment, in particular how new energy-efficient technologies relate to human productivity and health. These efforts are interdisciplinary, involving engineering, optometry, and medicine. The program facilities are described and the personnel in the program is identified.

  14. An Overview of State Policies Supporting Worksite Health Promotion Programs.

    Science.gov (United States)

    VanderVeur, Jennifer; Gilchrist, Siobhan; Matson-Koffman, Dyann

    2017-05-01

    Worksite health promotion (WHP) programs can reduce the occurrence of cardiovascular disease risk factors. State law can encourage employers and employer-provided insurance companies to offer comprehensive WHP programs. This research examines state law authorizing WHP programs. Quantitative content analysis. Worksites or workplaces. United States (and the District of Columbia). State law in effect in 2013 authorizing WHP programs. Frequency and distribution of states with WHP laws. To determine the content of the laws for analysis and coding, we identified 18 policy elements, 12 from the Centers for Disease Control and Prevention's Worksite Health ScoreCard (HSC) and 6 additional supportive WHP strategies. We used these strategies as key words to search for laws authorizing WHP programs or select WHP elements. We calculated the number and type of WHP elements for each state with WHP laws and selected two case examples from states with comprehensive WHP laws. Twenty-four states authorized onsite WHP programs, 29 authorized WHP through employer-provided insurance plans, and 18 authorized both. Seven states had a comprehensive WHP strategy, addressing 8 or more of 12 HSC elements. The most common HSC elements were weight management, tobacco cessation, and physical activity. Most states had laws encouraging the adoption of WHP programs. Massachusetts and Maine are implementing comprehensive WHP laws but studies evaluating their health impact are needed.

  15. Research program on radioactive wastes - Overview report for 2011

    International Nuclear Information System (INIS)

    Brander, S.

    2012-01-01

    This report for the Swiss Federal Office of Energy (SFOE) summarises the program's main points of interest and the work done in the year 2011 along with the results obtained. The aims of the program are recapitulated. The research program is co-ordinated by a working group comprising the Swiss Federal Office of Energy, the Swiss Federal Nuclear Safety Inspectorate ENSI, the Commission on Nuclear Waste Disposal and the Commission for Safety in Nuclear Installations, Some highlights of the research program are briefly described and discussed. Topics covered concern the marking of nuclear waste repositories, value judgement and opinion building, waste management as well as repository design, including dimensioning and monitoring systems, National and international co-operation is also discussed

  16. Overview of implementation of DARPA GPU program in SAIC

    Science.gov (United States)

    Braunreiter, Dennis; Furtek, Jeremy; Chen, Hai-Wen; Healy, Dennis

    2008-04-01

    This paper reviews the implementation of DARPA MTO STAP-BOY program for both Phase I and II conducted at Science Applications International Corporation (SAIC). The STAP-BOY program conducts fast covariance factorization and tuning techniques for space-time adaptive process (STAP) Algorithm Implementation on Graphics Processor unit (GPU) Architectures for Embedded Systems. The first part of our presentation on the DARPA STAP-BOY program will focus on GPU implementation and algorithm innovations for a prototype radar STAP algorithm. The STAP algorithm will be implemented on the GPU, using stream programming (from companies such as PeakStream, ATI Technologies' CTM, and NVIDIA) and traditional graphics APIs. This algorithm will include fast range adaptive STAP weight updates and beamforming applications, each of which has been modified to exploit the parallel nature of graphics architectures.

  17. Vulnerability and Risk Analysis Program: Overview of Assessment Methodology

    National Research Council Canada - National Science Library

    2001-01-01

    .... Over the last three years, a team of national laboratory experts, working in partnership with the energy industry, has successfully applied the methodology as part of OCIP's Vulnerability and Risk Analysis Program (VRAP...

  18. Ultra-Low-Energy Sub-Threshold Circuits: Program Overview

    National Research Council Canada - National Science Library

    Chandrakasan, Anantha

    2007-01-01

    In this DARPA program, we have developed a robust design methodology to scale power supply voltages to levels as low as 250mV, reducing the energy dissipation of digital computation by an order of magnitude...

  19. Overview of the Nuclear Regulatory Commission's safety research program

    International Nuclear Information System (INIS)

    Beckjord, E.S.

    1989-01-01

    Accomplishments during 1988 of the Office of Nuclear Regulatory Research and the program of safety research are highlighted, and plans, expections, and needs of the next year and beyond are discussed. Topics discussed include: ECCS Appendix K Revision; pressurized thermal shock; NUREG-1150, or the PRA method performance document; resolution of station blackout; severe accident integration plan; nuclear safety research review committee; and program management

  20. The Marshall Islands radioassay quality assurance program. An overview

    International Nuclear Information System (INIS)

    Hamilton, T.F.; Robison, W.L.; Kehl, S.; Stoker, A.C.; Conrado, C.L.

    2000-01-01

    An extensive quality assurance program to provide high quality data and assessments in support of the Marshall Islands Dose Assessment and Radioecology Program has been developed the Lawrence Livermore National Laboratory. Quality assurance objectives begin with the premise of providing integrated and cost-effective program support (to meet wide-ranging programmatic needs, scientific peer review, and build public confidence) and continue through from design and implementation of large-scale field programs, sampling and sample preparation, radiometric and chemical analyses, documentation of quality assurance/quality control practices, exposure assessments, and dose/risk assessments until publication. The basic structure of the radioassay quality assurance/quality control program can be divided into four essential elements: (1) sample and data integrity control, (2) instrument validation and calibration, (3) method performance testing, validation, development and documentation, and (4) periodic peer review and on-site assessments. While the quality assurance objectives are tailored towards a single research program and the evaluation of major exposure pathways/critical radionuclides pertinent to the Marshall Islands, quality assurance practices that are consistent with proposed criteria designed for laboratory accreditation were attempted to be developed. (author)

  1. Overview of the French program in chemical separations and transmutation

    International Nuclear Information System (INIS)

    Baudin, G.

    1993-01-01

    A long-range effort has begun in France that is aimed at the reduction of the volume and activity level of wastes containing long half-life radionuclides. This effort constitutes the SPIN (SeParations-INcineration) Program which investigates separations techniques that can improve current reprocessing technologies coupled with destruction of long-lived species through transmutation. Removal and destruction of specific radionuclides (e.g., neptunium, americium, technetium, iodine, cesium, and strontium) will be emphasized. Advanced solvent extraction chemistry focusing, for example, on development and implementation of diamides for actinide-lanthanide separations constitutes an important component of the SPIN program. The second component of the program focuses on inventory reductions through transmutation of such long-lived nuclides in fast reactor systems (Super Phenix). Accelerator-based systems are also being evaluated as a possible long-term option. Both of these components of the SPIN program are aimed at further reduction of the potential radiotoxicity and radiological impact of high-level wastes destined for geological storage. In this presentation, major activities of the SPIN Program will be described with emphasis on activities related to advanced chemical separations

  2. Healthy cities: overview of a WHO international program.

    Science.gov (United States)

    Goldstein, G

    2000-01-01

    Health is the outcome of all the factors and activities impinging upon the lives of individuals and communities. The last decade has seen an emerging understanding within development circles that living conditions are greatly affected by local action, by the work of local government, and by community groups and organizations. In addressing health and environmental issues and making interventions, an integrated approach, based on 'settings', exemplified in the Healthy Cities approach, has proved most effective. A Healthy City project can involve people and organizations in the programs and activities that are needed for better health, and enables a city or neighborhood to mobilize the human and financial resources required to address many health and quality of life issues. The WHO program involves implementating city projects and networks in all regions of the world and serves as a vehicle for many health programs, including major disease control initiatives. Healthy City projects allow Ministries of Health to develop stronger partnerships with local government organizations (such as the Union of Local Authorities and its members, "Local Agenda 21" initiatives, and others). One focus for the program is the development of 'multi-'multi-city action plans' for major global priority issues, including AIDS, sanitation, women's health, and violence, to ensure that major public health programs are strengthened by wider community participation. It is recognized that city networking--at national, regional, and international levels--now must be better exploited by individual cities and municipalities to solve local health problems.

  3. NASA RPS Program Overview: A Focus on RPS Users

    Science.gov (United States)

    Hamley, John A.; Sutliff, Thomas J.; Sandifer, Carl E., II; Zakrajsek, June F.

    2016-01-01

    The goal of NASA's Radioisotope Power Systems (RPS) Program is to make RPS ready and available to support the exploration of the solar system in environments where the use of conventional solar or chemical power generation is impractical or impossible to meet the needs of the missions. To meet this goal, the RPS Program, working closely with the Department of Energy, performs mission and system studies (such as the recently released Nuclear Power Assessment Study), assesses the readiness of promising technologies to infuse in future generators, assesses the sustainment of key RPS capabilities and knowledge, forecasts and tracks the Programs budgetary needs, and disseminates current information about RPS to the community of potential users. This process has been refined and used to determine the current content of the RPS Programs portfolio. This portfolio currently includes an effort to mature advanced thermoelectric technology for possible integration into an enhanced Multi-Mission Radioisotope Generator (eMMRTG), sustainment and production of the currently deployed MMRTG, and technology investments that could lead to a future Stirling Radioisotope Generator (SRG). This paper describes the program planning processes that have been used, the currently available MMRTG, and one of the potential future systems, the eMMRTG.

  4. Overview of US Fusion Energy Programs: January 1993

    International Nuclear Information System (INIS)

    Crandall, D.H.

    1994-01-01

    The US Fusion Program is in open-quotes Transition.close quotes This happens so infrequently that no one knows exactly what to expect; it makes everyone a little skittish. Program leadership does make a difference; Secretary Watkins was a positive force for fusion. Energy Research Director Happer remains in his position and is a positive force for scientific quality. Secretary O'Leary has stated that open-quotes Fusion energy holds great promise as an element of the nation's long-term energy supply.close quotes While new leaders may seek new directions with important implications for fusion, it seems reasonable to expect that, for fusion, such changes are likely to emerge slowly. Thus the assumption now is that the fusion priorities remain unchanged. In the spirit of optimism surrounding the new administration, the Fusion Energy Program's intention is to make as much progress as possible on the course presently established

  5. Overview of the US Magnetic Fusion Energy Program

    International Nuclear Information System (INIS)

    Wiffen, F.W.; Dowling, R.J.; Marton, W.A.; Eckstrand, S.A.

    1990-01-01

    Since the 1988 Symposium on Fusion Technology, steady progress has been made in the US Magnetic Fusion Energy Program. The large US tokamaks have reached new levels of plasma performance with associated improvements in the understanding of transport. The technology support for ongoing and future devices is similarly advancing with notable advances in magnetic, rf heating tubes, pellet injector, plasma interactive materials, tritium handling, structural materials, and system studies. Currently, a high level DOE review of the program is underway to provide recommendations for a strategic plan

  6. Overview of the TFTR Lithium Blanket Module program

    International Nuclear Information System (INIS)

    Jassby, D.L.

    1986-01-01

    The LBM (Lithium Blanket Module) is an approximately cubic module, about 80 cm on each side, with construction representative of a helium-cooled lithium oxide fusion reactor blanket module. Measurements of neutron transport and tritium breeding in the LBM will be made in irradiation programs first with a point-neutron source, and subsequently with the D-D and D-T fusion-neutron sources of the TFTR. This paper summarizes the objectives of the LBM program, the design, development and construction of the LBM, and progress in the experimental tests

  7. High-level waste immobilization program: an overview

    International Nuclear Information System (INIS)

    Bonner, W.R.

    1979-09-01

    The High-Level Waste Immobilization Program is providing technology to allow safe, affordable immobilization and disposal of nuclear waste. Waste forms and processes are being developed on a schedule consistent with national needs for immobilization of high-level wastes stored at Savannah River, Hanford, Idaho National Engineering Laboratory, and West Valley, New York. This technology is directly applicable to high-level wastes from potential reprocessing of spent nuclear fuel. The program is removing one more obstacle previously seen as a potential restriction on the use and further development of nuclear power, and is thus meeting a critical technological need within the national objective of energy independence

  8. Overview of the EPA quality system for environmental programs

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, G.L. [Environmental Protection Agency, Research Triangle Park, NC (United States)

    1993-12-31

    Formalized quality assurance program requirements for the U.S. Environmental Protection Agency (EPA) have been established for more than a decade. During this period, the environmental issues and concerns addressed by the EPA have changed. Many issues, such as ozone depletion and global climate warming, have become international concerns among the world environmental community. Other issues, such as hazardous waste cleanup and clean air, remain a focus of national environmental concerns. As the environmental issues of the 1980`s evolved, the traditional quality assurance (QA) program was transformed through the use of quality management principles into a Quality System to help managers meet the needs of the 1990`s and beyond.

  9. Research program on radioactive wastes - Overview report 2012

    International Nuclear Information System (INIS)

    Brander, S.

    2013-01-01

    This short report issued by the Swiss Federal Office of Energy (SFOE) takes a look at the work done within the framework of the Swiss Research Program on Radioactive Wastes. The program was developed in 2006/2007 by the various federal institutes and commissions involved together with an university of applied sciences. Points investigated included long-term aspects, the planning of deep repositories, opinion building and acceptance as well as depository concepts. Highlights in the research and development areas are discussed, including knowledge conservation, marking concepts, storage of radioactive wastes, repository conception, monitoring and sociological aspects. National and international co-operation in these areas are reported on

  10. Overview of the EPA quality system for environmental programs

    International Nuclear Information System (INIS)

    Johnson, G.L.

    1993-01-01

    Formalized quality assurance program requirements for the U.S. Environmental Protection Agency (EPA) have been established for more than a decade. During this period, the environmental issues and concerns addressed by the EPA have changed. Many issues, such as ozone depletion and global climate warming, have become international concerns among the world environmental community. Other issues, such as hazardous waste cleanup and clean air, remain a focus of national environmental concerns. As the environmental issues of the 1980's evolved, the traditional quality assurance (QA) program was transformed through the use of quality management principles into a Quality System to help managers meet the needs of the 1990's and beyond

  11. Overview of the TFTB lithium blanket module program

    International Nuclear Information System (INIS)

    Jassby, D.L.

    1986-01-01

    The Lithium Blanket Module (LBM) is an ∼ 80-cm 3 module, representative of a helium-cooled lithium oxide fusion reactor blanket module. This paper summarizes the design, development, and construction of the LBM, and indicates the present status of the LBM program

  12. Overview of U.S. programs for hydrogen from renewables

    International Nuclear Information System (INIS)

    Lewis, M.

    2007-01-01

    This paper discusses US program for hydrogen from renewable energy sources. Renewable energy sources include biomass, wind, solar, hydropower, geothermal and ocean waves. Although nuclear power is not considered renewable, a case can be made that it is, but requires recycling of spent fuel. The paper also discusses hydrogen production, storage and delivery. It discusses fuel cells, safety codes and standards and system analysis

  13. Energy-Related Inventions Program: an overview of the evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Soderstrom, E.J.; Bronfman, L.M.; Rorke, M.G.

    1983-09-01

    The Energy-Related Inventions Program (ERIP) is jointly administered by the US Departments of Energy and Commerce. Grants were awarded for 165 of 208 inventions recommended by the National Bureau of Standards (NBS). Of the 165 inventions, 46 have been able to acquire follow-on financing from a variety of sources. Further, 35 of the inventions have reached the marketplace, and their cumulative sales to date total $178 million. An additional 10 inventions are now starting into production. Jobs that have been created directly by production related to the inventions total 756; additional spin-off jobs attributable to the inventions include component and material suppliers, jobbers, franchisees, and distributors. The program was recently evaluated at Oak Ridge National Laboratory, with the following conclusions: (1) the evaluation process at NBS has been successful in identifying technically and economically feasible inventions, (2) the success rate for the program is about equivalent to the reported success rates of private venture capital firms, (3) the program is supporting inventions at a point in their development where they are supported by neither the venture capital community nor industry, and (4) the one-time DOE grants and the associated ERIP support to inventors have been successful in readying inventors for follow-on financing from the private sector.

  14. Computing, Information, and Communications Technology (CICT) Program Overview

    Science.gov (United States)

    VanDalsem, William R.

    2003-01-01

    The Computing, Information and Communications Technology (CICT) Program's goal is to enable NASA's Scientific Research, Space Exploration, and Aerospace Technology Missions with greater mission assurance, for less cost, with increased science return through the development and use of advanced computing, information and communication technologies

  15. Overview of Gas Research Institute environmental research programs

    International Nuclear Information System (INIS)

    Evans, J.M.

    1991-01-01

    The Gas Research Institute (GRI) is a private not-for-profit membership organization of natural gas pipelines, distribution companies and natural gas producers. GRI's purpose is to plan, to manage and to develop financing for a gas-related research and development (R and D) program on behalf of its members and their customers. GRI does not do any research itself. GRI's R and D program is designed to provide advanced technologies for natural gas supply, transport, storage, distribution and end-use applications in all markets. In addition, basic research is conducted for GRI in these areas to build a foundation for future technology breakthroughs. Work in the Environment and Safety Research Department includes sections interested in: supply related research, air quality research, end use equipment safety research, gas operations safety research, and gas operations environmental research. The Natural Gas Supply Program has research ongoing in such areas as: restoration of pipeline right-of-ways; cleaning up town gas manufacturing sites; the development of methanogenic bacteria for soil and groundwater cleanup; development of biological fluidized carbon units for rapid destruction of carbonaceous compounds; research on liquid redox sulfur recovery for sulfur removal from natural gas; research on produced water and production wastes generated by the natural gas industry; environmental effects of coalbed methane production; and subsurface effects of natural gas operations. The western coalbed methane and ground water programs are described

  16. Solar Program Overview: Fiscal Years 2002& 2003 (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2004-06-01

    This document describes the research activities and accomplishments of the DOE Solar Energy Technologies Program for fiscal years 2002 and 2003. It includes detailed accounts, charts, and photos of R&D activities in the areas of photovoltaics, concentrating solar power, and solar heating and lighting

  17. Seismic safety margins research program. Phase I final report - Overview

    International Nuclear Information System (INIS)

    Smith, P.D.; Dong, R.G.; Bernreuter, D.L.; Bohn, M.P.; Chuang, T.Y.; Cummings, G.E.; Johnson, J.J.; Mensing, R.W.; Wells, J.E.

    1981-04-01

    The Seismic Safety Margins Research Program (SSMRP) is a multiyear, multiphase program whose overall objective is to develop improved methods for seismic safety assessments of nuclear power plants, using a probabilistic computational procedure. The program is being carried out at the Lawrence Livermore National Laboratory and is sponsored by the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. Phase I of the SSMRP was successfully completed in January 1981: A probabilistic computational procedure for the seismic risk assessment of nuclear power plants has been developed and demonstrated. The methodology is implemented by three computer programs: HAZARD, which assesses the seismic hazard at a given site, SMACS, which computes in-structure and subsystem seismic responses, and SEISIM, which calculates system failure probabilities and radioactive release probabilities, given (1) the response results of SMACS, (2) a set of event trees, (3) a family of fault trees, (4) a set of structural and component fragility descriptions, and (5) a curve describing the local seismic hazard. The practicality of this methodology was demonstrated by computing preliminary release probabilities for Unit 1 of the Zion Nuclear Power Plant north of Chicago, Illinois. Studies have begun aimed at quantifying the sources of uncertainty in these computations. Numerous side studies were undertaken to examine modeling alternatives, sources of error, and available analysis techniques. Extensive sets of data were amassed and evaluated as part of projects to establish seismic input parameters and to produce the fragility curves. (author)

  18. An Overview of the EPRI PWR Primary Chemistry Program

    International Nuclear Information System (INIS)

    Perkins, David; Fruzzetti, Keith; Haas, Carey; Wells, Dan

    2012-09-01

    Primary chemistry controls continue to evolve, impacting long term equipment reliability goals, optimized core designs, and radiation dose management practices. Chemistry initiatives include increased primary system pH (T) , zinc injection, and optimization of primary system hydrogen concentration. Nevertheless, utilities are faced with ever changing challenges as fuel vendors continue to optimize core power densities coupled with longer operating cycles and material replacement efforts. These challenges must be collaboratively addressed by the plant chemists, engineers, and operators. Operational chemistry has changed dramatically over the years with increased primary pH (T) programs requiring some utilities to operate with up to 6 ppm lithium or slightly higher. Coupled with primary pH (T) program optimization, are ongoing EPRI research efforts attempting to develop an optimized hydrogen control program balancing material issues associated with primary water stress corrosion cracking (PWSCC) crack growth rate against fuel concerns associated with increased hydrogen concentrations. One of the most significant primary chemistry changes that effectively balances the demands of materials, fuels, chemistry and dose management strategies is zinc injection into the primary coolant. Since 1994 when Farley initiated zinc injection, zinc injection has been successfully injected at over 70 pressurized water reactors world-wide. Combining operational chemistry with shutdown chemistry controls provides the plant chemist with a technically based and balanced approach to fuel and material integrity as well as dose management strategies. Shutdown chemistry has continually evolved since the 1970's when the chemist was primarily concerned with fission products. Now the chemist must manage corrosion product release, and support Outage Management and Radiation Protection through the performance of a controlled shutdown. In part, this change was driven as plant materials evolved

  19. Aviation Safety Program: Weather Accident Prevention (WxAP) Project Overview and Status

    Science.gov (United States)

    Nadell, Shari-Beth

    2003-01-01

    This paper presents a project overview and status for the Weather Accident Prevention (WxAP) aviation safety program. The topics include: 1) Weather Accident Prevention Project Background/History; 2) Project Modifications; 3) Project Accomplishments; and 4) Project's Next Steps.

  20. An overview of environment Canada's National Incinerator Testing and Evaluation Program (NITEP)

    International Nuclear Information System (INIS)

    Finkelstein, A.

    1991-01-01

    In response to the many concerns associated with incineration, Environment Canada established the National Incineration Testing and evaluation Program (NITEP) in 1984. It's mission was to assess the incineration process as a means for disposal of MSW in Canada. The program primarily focused on the environment and health impacts of MSW incinerators by determining how design and operating conditions can be modified to reduce emissions of concern. In addition to developing better measuring and monitoring methods, supporting ash residue management research programs, NITEP established four major field projects to develop the data base necessary for national guidelines. This paper presents a brief overview of the most significant field program findings over the past six years and the rationale for the Canadian Council of Ministers of the Environment (CCME) Operating and Emissions Guidelines for MSW Incinerators published in June of 1989. In addition an overview of the ash work completed to date, and work still underway, will be presented

  1. Research program on regulatory safety - Overview report 2010

    International Nuclear Information System (INIS)

    Mailaender, R

    2011-01-01

    This report for the Swiss Federal Office of Energy (SFOE) summarises the program's main points of interest, work done in the year 2010 and the results obtained. The main highlights of the research program, which was co-ordinated by the Swiss Federal Nuclear Safety Inspectorate ENSI are reported on. Topics reported on include nuclear fuels and materials, the development of a data base on damage and internal incidents, external incidents and human factors. Also, system behaviour and hazardous accident events are reported on, as are radiation protection and waste disposal. Project highlights include the KORA II project, which examined corrosion crack development in austenitic structural materials, the OECD's Halden Reactor Project in the man-technology-organisational area, and work done in the Mont Terri rock research laboratory. Also, national and international co-operation is briefly looked at and work to be done in 2011 is reviewed. A list of current and completed projects completes the report

  2. Overview of the X-band R and D Program

    International Nuclear Information System (INIS)

    2002-01-01

    An electron/positron linear collider with a center-of-mass energy between 0.5 and 1 TeV is recognized as an important complement to the physics program of the LHC. The Next Linear Collider (NLC) is being designed by a US collaboration (FNAL, LBNL, LLNL, and SLAC) which is working closely with the Japanese collaboration that is designing the Japanese Linear Collider (JLC). The NLC/JLC main linacs are based on normal conducting 11 GHz rf. This paper will discuss the status of the NLC design. Results from the ongoing R and D programs, including the recently uncovered high gradient damage problem, will be discussed along with changes to the optical design and collider layout which were made to enhance the collider capabilities

  3. Overview PWR-Blowdown Heat Transfer Separate-Effects Program

    International Nuclear Information System (INIS)

    White, J.D.

    1978-01-01

    The ORNL Pressurized Water Reactor Blowdown Heat Transfer Program (PWR-BDHT) is a separate-effects experimental study of thermal-hydraulic phenomena occurring during the first 20 sec of a hypothetical LOCA. Specific objectives include the determination, for a wide range of parameters, of time to CHF and the following variables for both pre- and post-CHF: heat fluxes, ΔT (temperature difference between pin surface and fluid), heat transfer coefficients, and local fluid properties. A summary of the most interesting results from the program obtained during the past year is presented. These results are in the area of: (1) RELAP verification, (2) electric pin calibration, (3) time to critical heat flux (CHF), (4) heat transfer coefficient comparisons, and (5) nuclear fuel pin simulation

  4. Overview of the Hanford Site Performance Assurance Program

    International Nuclear Information System (INIS)

    Duncan, M.R.; Billings, M.P.; Delvin, W.L.; Scott, D.D.; Weatherby, J.W.

    1991-01-01

    This paper reports on a safeguards and security performance assurance program which encompasses the routine and special activities carried out to assure that safeguards and security subsystems and components are operating in a effective and reliable manner. At the Hanford Site, performance assurance involves widely varied activities, e.g., force-on-force exercises, functional testing of security components, and limited scope performance testing of material control and accountability subsystems. These activities belong to one of four categories: performance testing, functional testing, inspection, and preventive maintenance. Using categories has aided in identifying and assessing the relevant contribution each activity makes to the performance assurance program. Efforts have progressed toward incorporating performance assurance activities into the assessment of protection effectiveness required for Master Safeguards and Security Agreement development and its associated verification and validation process

  5. Overview of the NASA balloon R&D program

    Science.gov (United States)

    Smith, I. Steve, Jr.

    1994-01-01

    The catastrophic balloon failure during the first half of the 1980's identified the need for a comprehensive and continuing balloon research and development (R&D) commitment by NASA. Technical understanding was lacking in many of the disciplines and processes associated with scientific ballooning. A comprehensive balloon R&D plan was developed in 1986 and implemented in 1987. The objectives were to develop the understanding of balloon system performance, limitations, and failure mechanisms. The program consisted of five major technical areas: structures, performance and analysis, materials, chemistry and processing, and quality control. Research activitites have been conducted at NASA/Goddard Space Flight Center (GSFC)-Wallops Flight Facility (WFF), other NASA centers and government facilities, universities, and the balloon manufacturers. Several new and increased capabilities and resources have resulted from this activity. The findings, capabilities, and plan of the balloon R&D program are presented.

  6. The U.S. RERTR Program: Overview, status and plans

    International Nuclear Information System (INIS)

    Travelli, A.

    1985-01-01

    The status of the Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a brief review of the accomplishments which the RERTR Program, in cooperation with its many international partners, had achieved by the end of 1983 in the area of LEU research reactor fuels development and application, emphasis is placed on the RERTR Program developments which took place during 1984 and on current plans and schedules. The RERTR progress in 1984 has been significant, with solid accomplishments and few surprises. Most LEU U 3 Si 2 -AI irradiation tests with 48 g U/cm 3 have been successfully completed, and contract negotiations are under way for the procurement of a whole-core demonstration of this fuel in the ORR. The demonstration is to begin in mid-1985 and to last for approximately eighteen months. Qualification of U 3 Si-AI fuel with 7 g U/cm 3 is scheduled for 1989. International cooperation among fuel developers, commercial vendors, and reactor operators has been essential to the progress which has been achieved. With continued international cooperation, it will be feasible to significantly reduce HEU usage in research reactors in the next few years. (author)

  7. An overview of the DIII-D program

    International Nuclear Information System (INIS)

    Luxon, J.L.

    1996-10-01

    The DIII-D program focuses on developing fusion physics in an integrated program of tokamak concept improvement. The intent is both to support the present ITER physics R and D and to develop more efficient concepts for the later phases of ITER and eventual power plants. Progress in this effort can be best summarized by recent results for a diverted deuterium discharge with negative central shear which reached a performance level of Q DT = 0.32. The ongoing development of the tools needed to carry out this program of understanding and optimization continues to be crucial to its success. Control of the plasma cross-sectional shape and the internal distributions of plasma current, density, and rotation has been essential to optimizing plasma performance. Advanced divertor concepts provide edge power and particle control for future devices such as ITER and provide techniques to help manage the edge power and particle flows for advanced tokamak concepts. New divertor diagnostics and improved modeling are developing excellent divertor understanding. Many of the plasma physics issues being posed by ITER are being addressed. Scrapeoff layer power flow is being characterized to provide an accurate basis for the design of reactor devices. Ongoing studies of the density limit focus on identifying ways in which ITER can achieve the required densities in excess of the Greenwald limit. Better understanding of disruptions is crucial to the design of future reactors

  8. An overview of DARPA's advanced space technology program

    Science.gov (United States)

    Nicastri, E.; Dodd, J.

    1993-02-01

    The Defense Advanced Research Projects Agency (DARPA) is the central research and development organization of the DoD and, as such, has the primary responsibility for the maintenance of U.S. technological superiority over potential adversaries. DARPA's programs focus on technology development and proof-of-concept demonstrations of both evolutionary and revolutionary approaches for improved strategic, conventional, rapid deployment and sea power forces, and on the scientific investigation into advanced basic technologies of the future. DARPA can move quickly to exploit new ideas and concepts by working directly with industry and universities. For four years, DARPA's Advanced Space Technology Program (ASTP) has addressed various ways to improve the performance of small satellites and launch vehicles. The advanced technologies that are being and will be developed by DARPA for small satellites can be used just as easily on large satellites. The primary objective of the ASTP is to enhance support to operational commanders by developing and applying advanced technologies that will provide cost-effective, timely, flexible, and responsive space systems. Fundamental to the ASTP effort is finding new ways to do business with the goal of quickly inserting new technologies into DoD space systems while reducing cost. In our view, these methods are prime examples of what may be termed 'technology leveraging.' The ASTP has initiated over 50 technology projects, many of which were completed and transitioned to users. The objectives are to quickly qualify these higher risk technologies for use on future programs and reduce the risk of inserting these technologies into major systems, and to provide the miniaturized systems that would enable smaller satellites to have significant - rather than limited - capability. Only a few of the advanced technologies are described, the majority of which are applicable to both large and small satellites.

  9. Overview of the National Water-Quality Assessment Program

    Science.gov (United States)

    Leahy, P.P.; Thompson, T.H.

    1994-01-01

    The Nation's water resources are the basis for life and our economic vitality. These resources support a complex web of human activities and fishery and wildlife needs that depend upon clean water. Demands for good-quality water for drinking, recreation, farming, and industry are rising, and as a result, the American public is concerned about the condition and sustainability of our water resources. The American public is asking: Is it safe to swim in and drink water from our rivers or lakes? Can we eat the fish that come from them? Is our ground water polluted? Is water quality degrading with time, and if so, why? Has all the money we've spent to clean up our waters, done any good? The U.S. Geological Survey's National Water-Quality Assessment (NAWQA) Program was designed to provide information that will help answer these questions. NAWQA is designed to assess historical, current, and future water-quality conditions in representative river basins and aquifers nationwide. One of the primary objectives of the program is to describe relations between natural factors, human activities, and water-quality conditions and to define those factors that most affect water quality in different parts of the Nation. The linkage of water quality to environmental processes is of fundamental importance to water-resource managers, planners, and policy makers. It provides a strong and unbiased basis for better decisionmaking by those responsible for making decisions that affect our water resources, including the United States Congress, Federal, State, and local agencies, environmental groups, and industry. Information from the NAWQA Program also will be useful for guiding research, monitoring, and regulatory activities in cost effective ways.

  10. An overview of the NASA Advanced Propulsion Concepts program

    International Nuclear Information System (INIS)

    Curran, F.M.; Bennett, G.L.; Frisbee, R.H.; Sercel, J.C.; Lapointe, M.R.

    1992-07-01

    NASA Advanced Propulsion Concepts (APC) program for the development of long-term space propulsion system schemes is managed by both NASA-Lewis and the JPL and is tasked with the identification and conceptual development of high-risk/high-payoff configurations. Both theoretical and experimental investigations have been undertaken in technology areas deemed essential to the implementation of candidate concepts. These APC candidates encompass very high energy density chemical propulsion systems, advanced electric propulsion systems, and an antiproton-catalyzed nuclear propulsion concept. A development status evaluation is presented for these systems. 45 refs

  11. Severe accident sequence assessment for boiling water reactors: program overview

    International Nuclear Information System (INIS)

    Fontana, M.H.

    1980-10-01

    The Severe Accident Sequence Assessment (SASA) Program was started at the Oak Ridge National Laboratory (ORNL) in June 1980. This report documents the initial planning, specification of objectives, potential uses of the results, plan of attack, and preliminary results. ORNL was assigned the Brown's Ferry Unit 1 Plant with the station blackout being the initial sequence set to be addressed. This set includes: (1) loss of offsite and onsite ac power with no coolant injection; and (2) loss of offsite and onsite ac power with high pressure coolant injection (HPCI) and reactor core isolation cooling (RCIC) as long as dc power supply lasts. This report includes representative preliminary results for the former case

  12. Overview and direction in the tandem mirror program

    International Nuclear Information System (INIS)

    Thomassen, K.I.

    1983-04-01

    There are two main thrusts to the tandem mirror program at the present time. One is to gather the experimental data base to verify the axicell thermal-barrier concept and the other to improve the end plugs for tandems. With such improvements one might approach the ideal fusion reactor, a simple solenoid of modular elements whose ends are but a modest perturbation on the configuration from both a cost and technological viewpoint. Progress toward these two goals is discussed here, and the directions to be taken in the immediate future are described

  13. Gasoline toxicology: overview of regulatory and product stewardship programs.

    Science.gov (United States)

    Swick, Derek; Jaques, Andrew; Walker, J C; Estreicher, Herb

    2014-11-01

    Significant efforts have been made to characterize the toxicological properties of gasoline. There have been both mandatory and voluntary toxicology testing programs to generate hazard characterization data for gasoline, the refinery process streams used to blend gasoline, and individual chemical constituents found in gasoline. The Clean Air Act (CAA) (Clean Air Act, 2012: § 7401, et seq.) is the primary tool for the U.S. Environmental Protection Agency (EPA) to regulate gasoline and this supplement presents the results of the Section 211(b) Alternative Tier 2 studies required for CAA Fuel and Fuel Additive registration. Gasoline blending streams have also been evaluated by EPA under the voluntary High Production Volume (HPV) Challenge Program through which the petroleum industry provide data on over 80 refinery streams used in gasoline. Product stewardship efforts by companies and associations such as the American Petroleum Institute (API), Conservation of Clean Air and Water Europe (CONCAWE), and the Petroleum Product Stewardship Council (PPSC) have contributed a significant amount of hazard characterization data on gasoline and related substances. The hazard of gasoline and anticipated exposure to gasoline vapor has been well characterized for risk assessment purposes. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  14. Status of the RERTR program: overview, progress and plans

    International Nuclear Information System (INIS)

    Travelli, A.

    1985-01-01

    The status of the US Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 . Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U 3 Si-Al fuel with approx.7 g U/cm 3 is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals

  15. Overview of the NRC nuclear waste management program

    International Nuclear Information System (INIS)

    Malaro, J.C.

    1976-01-01

    The NRC has firmly established waste management as a high-priority effort and has made the commitment to act rapidly and methodically to establish a sound regulatory base for licensing waste management activities. We believe the priorities for NRC work in waste management are consistent with the needs of the overall national waste management program. Present licensing procedures and criteria are adequate for the short term, and priority attention is being given to the longer term, when the quantities of waste to be managed will be greater and licensing demands will increase. Recognizing that its decision will affect industry, other governmental jurisdictions, private interest groups, and the public at large, NRC has encouraged and will continue to encourage their participation in planning our program. We also recognize that the problems of nuclear waste management are international in scope. Many waste management problems (e.g., potential for contamination of oceans and atmosphere, need for isolation of some wastes for longer periods than governments and political boundaries have remained stable in the past), require a set of internationally acceptable and accepted solutions. The wastes from the U.S. nuclear industry will account for only about one third of the nuclear waste generated in the world. Therefore, we propose to cooperate and where appropriate take the lead in establishing acceptable worldwide policies, standards and procedures for handling nuclear wastes

  16. Overview of NRC's human factors regulatory research program

    International Nuclear Information System (INIS)

    Coffman, F.D. Jr.

    1989-01-01

    The human factors research program is divided into distinct and interrelated program activities: (1) Personnel Performance measurement, (2) Personnel Subsystem, (3) Human-System Interface, (4) Organization and Management, and (5) a group of Reliability Assessment activities. The purpose of the Personnel Performance Measurement activity is to improve the Agency's understanding of the factors influencing personnel performance and the effects on the safety of nuclear operations and maintenance by developing improvements to methods for collecting and managing personnel performance data. Personnel Subsystem research will broaden the understanding of such factors as staffing, qualifications, and training that influence human performance in the nuclear system and will develop the technical basis for regulatory guidance to reduce any adverse impact of these influences on nuclear safety. Research in the Human-System Interface activity will provide the technical basis for ensuring that the interface between the system and the human user supports safe operations and maintenance. Organization and Management research will result in the development of tools for evaluating organization and management issues within the nuclear industry. And finally, the Reliability Assessment group of activities includes multidisciplinary research that will integrate human and hardware considerations for evaluating reliability and risk in NRC licensing, inspection, and regulatory decisions

  17. Overview of the department of energy carbon dioxide research program

    International Nuclear Information System (INIS)

    Riches, M.R.; Koomanoff, F.A.

    1985-01-01

    The goal of the Department of Energy (DOE) Carbon Dioxide Research Program is to identify possible policy options for government action in response to effects of increased CO 2 . The achievement of this goal requires a significant increase in our scientific knowledge of the atmosphere, the biosphere, the oceans, and the cryosphere-their interactions and the effects that increasing atmospheric CO 2 and other trace gases will have on them. To identify and specify valid choices, a program of directed research is required. The research areas include: Projection of future atmospheric CO 2 concentrations Estimation of Co 2 -induced global/regional climate changes Estimation of crop and ecosystem response to CO 2 -induced changes Estimation of the effect of CO 2 -induced climate changes on sea level, fisheries, and human health. This paper describes the present DOE plan to address the questions related to the global and regional rate of CO 2 -induced climate change. The objective of the plan is to define the key questions in such a way that research is directed at experiments where answers are needed rather than at experiments where answers can be easily obtained. Only through this kind of focus can we expect to provide the climate-change estimates required for the policy process

  18. The status of the RERTR Program: Overview, progress and plans

    International Nuclear Information System (INIS)

    Travelli, A.

    1985-01-01

    The status of the U.S. Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U 3 Si 2 -AI and U 3 Si-AI fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U 3 Si 2 -AI fuel at 4.8 g U/cm 3 . Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U 3 Si-AI fuel with ∼7 g U/cm 3 is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals. (author)

  19. An overview of the United States dose reassessment program

    International Nuclear Information System (INIS)

    Christy, R.F.

    1983-01-01

    The US Dose Reassessment Program consists of a number of separate efforts to reexamine all the stages from the initial assembly of the fissionable material, through the transport of neutrons and gamma rays, to the final deposition of the dose of ionizing radiation. Where possible, experimental measurements will be used to normalize the calculations. This program is summarized as follows: (1) calculations on the output of prompt neutrons and gamma rays from the detonating bomb, by Los Alamos National Laboratory (LANL), including calculation of the output of various test bombs where measurements have been made and of a critical assembly of a Hiroshima type bomb, (2) transport calculations for prompt neutrons and gamma rays in air by Oak Ridge National Laboratory (ORNL) and Lawrence Livermore National Laboratory (LLNL) including transport in air of gamma rays secondary to prompt neutrons and calculation of various test devices, (3) calculation of the emission and transport in air of delayed gamma rays from the cloud of fission products by Science Applications, Inc. (SAI) which can also include delayed neutron calculations, (4) calculations of the shielding effects of buildings, etc., on the neutron and gamma ray flux by SAI and ORNL, (5) calculation of organ doses and transport in the body by ORNL and SAI, (6) calibration of in situ measurements by LLNL and ORNL, (7) thermoluminescent (TL) dosimetry to determine gamma ray flux by the Japanese National Institute of Radiological Sciences and the University of Utah, and (8) review of information on bomb yield by LANL and ORNL. (author)

  20. Spitzer ultra faint survey program (surfs up). I. An overview

    Energy Technology Data Exchange (ETDEWEB)

    Bradač, Maruša; Huang, Kuang-Han; Cain, Benjamin; Hall, Nicholas; Lubin, Lori [Department of Physics, University of California, Davis, CA 95616 (United States); Ryan, Russell; Casertano, Stefano [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Lemaux, Brian C. [Aix Marseille Université, CNRS, LAM (Laboratoire d' Astrophysique de Marseille) UMR 7326, F-13388 Marseille (France); Schrabback, Tim; Hildebrandt, Hendrik [Argelander-Institut für Astronomie, Auf Dem Hügel 71, D-53121 Bonn (Germany); Gonzalez, Anthony H. [Department of Astronomy, University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611 (United States); Allen, Steve; Von der Linden, Anja [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 382 Via Pueblo Mall, Stanford, CA 94305-4060 (United States); Gladders, Mike [The University of Chicago, The Kavli Institute for Cosmological Physics, 933 East 56th Street, Chicago, IL 60637 (United States); Hinz, Joannah; Zaritsky, Dennis [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Treu, Tommaso, E-mail: marusa@physics.ucdavis.edu [Department of Physics, University of California, Santa Barbara, CA 93106 (United States)

    2014-04-20

    Spitzer UltRa Faint SUrvey Program is a joint Spitzer and Hubble Space Telescope Exploration Science program using 10 galaxy clusters as cosmic telescopes to study z ≳ 7 galaxies at intrinsically lower luminosities, enabled by gravitational lensing, than blank field surveys of the same exposure time. Our main goal is to measure stellar masses and ages of these galaxies, which are the most likely sources of the ionizing photons that drive reionization. Accurate knowledge of the star formation density and star formation history at this epoch is necessary to determine whether these galaxies indeed reionized the universe. Determination of the stellar masses and ages requires measuring rest-frame optical light, which only Spitzer can probe for sources at z ≳ 7, for a large enough sample of typical galaxies. Our program consists of 550 hr of Spitzer/IRAC imaging covering 10 galaxy clusters with very well-known mass distributions, making them extremely precise cosmic telescopes. We combine our data with archival observations to obtain mosaics with ∼30 hr exposure time in both 3.6 μm and 4.5 μm in the central 4' × 4' field and ∼15 hr in the flanking fields. This results in 3σ sensitivity limits of ∼26.6 and ∼26.2 AB magnitudes for the central field in the IRAC 3.6 and 4.5 μm bands, respectively. To illustrate the survey strategy and characteristics we introduce the sample, present the details of the data reduction and demonstrate that these data are sufficient for in-depth studies of z ≳ 7 sources (using a z = 9.5 galaxy behind MACS J1149.5+2223 as an example). For the first cluster of the survey (the Bullet Cluster) we have released all high-level data mosaics and IRAC empirical point-spread function models. In the future we plan to release these data products for the entire survey.

  1. Human Research Program Advanced Exercise Concepts (AEC) Overview

    Science.gov (United States)

    Perusek, Gail; Lewandowski, Beth; Nall, Marsha; Norsk, Peter; Linnehan, Rick; Baumann, David

    2015-01-01

    Exercise countermeasures provide benefits that are crucial for successful human spaceflight, to mitigate the spaceflight physiological deconditioning which occurs during exposure to microgravity. The NASA Human Research Program (HRP) within the Human Exploration and Operations Mission Directorate (HEOMD) is managing next generation Advanced Exercise Concepts (AEC) requirements development and candidate technology maturation to Technology Readiness Level (TRL) 7 (ground prototyping and flight demonstration) for all exploration mission profiles from Multi Purpose Crew Vehicle (MPCV) Exploration Missions (up to 21 day duration) to Mars Transit (up to 1000 day duration) missions. These validated and optimized exercise countermeasures systems will be provided to the ISS Program and MPCV Program for subsequent flight development and operations. The International Space Station (ISS) currently has three major pieces of operational exercise countermeasures hardware: the Advanced Resistive Exercise Device (ARED), the second-generation (T2) treadmill, and the cycle ergometer with vibration isolation system (CEVIS). This suite of exercise countermeasures hardware serves as a benchmark and is a vast improvement over previous generations of countermeasures hardware, providing both aerobic and resistive exercise for the crew. However, vehicle and resource constraints for future exploration missions beyond low Earth orbit will require that the exercise countermeasures hardware mass, volume, and power be minimized, while preserving the current ISS capabilities or even enhancing these exercise capabilities directed at mission specific physiological functional performance and medical standards requirements. Further, mission-specific considerations such as preservation of sensorimotor function, autonomous and adaptable operation, integration with medical data systems, rehabilitation, and in-flight monitoring and feedback are being developed for integration with the exercise

  2. Overview and status of the SIMMER testing program

    International Nuclear Information System (INIS)

    Scott, J.H.

    1979-01-01

    Los Alamos Scientific Laboratory has undertaken an extensive experiment analysis program to test the results of SIMMER Liquid Metal Fast Breeder Reactor (LMFBR) accident calculations. Initially, we will test the postdisassembly work-energy partition problem. The SIMMER-calculated order-of-magnitude reduction of available kinetic energy following a severe hypothetical core-disruptive accident (HCDA) can be attributed to (1) purely fluid-dynamic effects; and (2) rate-controlled effects, such as phase transitions and heat transfer. We have chosen to test separately each class of mitigator. In this paper we review the experiments initially chosen for testing of each class of mitigator and report on the status of the analyses. We enumerate several problems in SIMMER that experiment analysis has disclosed. Finally, needs for future experiments are discussed

  3. Strategic Defense Initiative Organization adaptive structures program overview

    Science.gov (United States)

    Obal, Michael; Sater, Janet M.

    In the currently envisioned architecture none of the Strategic Defense System (SDS) elements to be deployed will receive scheduled maintenance. Assessments of performance capability due to changes caused by the uncertain effects of environments will be difficult, at best. In addition, the system will have limited ability to adjust in order to maintain its required performance levels. The Materials and Structures Office of the Strategic Defense Initiative Organization (SDIO) has begun to address solutions to these potential difficulties via an adaptive structures technology program that combines health and environment monitoring with static and dynamic structural control. Conceivable system benefits include improved target tracking and hit-to-kill performance, on-orbit system health monitoring and reporting, and threat attack warning and assessment.

  4. Urban Dispersion Program Overview and MID05 Field Study Summary

    Energy Technology Data Exchange (ETDEWEB)

    Allwine, K Jerry; Flaherty, Julia E.

    2007-07-31

    The Urban Dispersion Program (UDP) was a 4-year project (2004–2007) funded by the U.S. Department of Homeland Security with additional support from the Defense Threat Reduction Agency. The U.S. Environmental Protection Agency (EPA) also contributed to UDP through funding a human-exposure component of the New York City (NYC) field studies in addition to supporting an EPA scientist in conducting modeling studies of NYC. The primary goal of UDP was to improve the scientific understanding of the flow and diffusion of airborne contaminants through and around the deep street canyons of NYC. The overall UDP project manager and lead scientist was Dr. Jerry Allwine of Pacific Northwest National Laboratory. UDP had several accomplishments that included conducting two tracer and meteorological field studies in Midtown Manhattan.

  5. The US Liquid-Metal Reactor Program - overview and status

    International Nuclear Information System (INIS)

    Quinn, J.E.; Gyorey, G.L.; Salerno, L.N.

    1992-01-01

    The US Advanced Liquid-Metal Reactor (ALMR) Program has three major elements being developed in an integrated fashion to produce a system meeting the US long-term nuclear energy needs. Reactor design, one of those elements, is the focus of this paper. The other two elements, the integral fast reactor metal-fuel cycle and the light water reactor (LWR) spent-fuel actinide recycle, will be addressed in companion papers. The ALMR is adaptable to multiple missions with few modifications such as the core arrangements. The missions identified to date are (a) the extension of the existing uranium resources through breeding and highly efficient uranium utilization, (b) the recycle and utilization of the long-life actinides in LWR spent fuel as fissile material for the ALMR, and (c) the conversion of excess weapons fissil material into electricity. In addition to these missions, the reactor design is adaptable to either the metal-fuel cycle or the oxide fuel cycle

  6. Overview of the United States steam generator development programs

    Energy Technology Data Exchange (ETDEWEB)

    Kaspar, P W; Lowe, P A

    1975-07-01

    The LMFBR steam generator development program of the USA was initiated to support the development of reliable designs and meaningful performance data for these critical components. Since the steam generators include the structural boundary between heated sodium and water, the consequences of small flaws in the materials that form the boundary are significant. Successful development and demonstration of commercial LMFBR power plants requires the consideration of many factors in addition to the design, construction and operation of a particular plant. Additional factors which must be assessed include: economics, reliability, safety, environment, operability, maintainability and conservation of the resources. In terms of the steam generator these items led to the selection of a single wall tube design using a forced recirculating system for the present Clinch River Breeder Reactor. There are strong economic incentives to use a once-through steam generating system in future designs.

  7. Geothermal energy program summary: Volume 1: Overview Fiscal Year 1988

    Science.gov (United States)

    1989-02-01

    Geothermal energy is a here-and-now technology for use with dry steam resources and high-quality hydrothermal liquids. These resources are supplying about 6 percent of all electricity used in California. However, the competitiveness of power generation using lower quality hydrothermal fluids, geopressured brines, hot dry rock, and magma still depends on the technology improvements sought by the DOE Geothermal Energy R and D Program. The successful outcome of the R and D initiatives will serve to benefit the U.S. public in a number of ways. First, if a substantial portion of our geothermal resources can be used economically, they will add a very large source of secure, indigenous energy to the nation's energy supply. In addition, geothermal plants can be brought on line quickly in case of a national energy emergency. Geothermal energy is also a highly reliable resource, with very high plant availability. For example, new dry steam plants at The Geysers are operable over 99 percent of the time, and the small flash plant in Hawaii, only the second in the United States, has an availability factor of 98 percent. Geothermal plants also offer a viable baseload alternative to fossil and nuclear plants -- they are on line 24 hours a day, unaffected by diurnal or seasonal variations. The hydrothermal power plants with modern emission control technology have proved to have minimal environmental impact. The results to date with geopressured and hot dry rock resources suggest that they, too, can be operated so as to reduce environmental effects to well within the limits of acceptability. Preliminary studies on magma are also encouraging. In summary, the character and potential of geothermal energy, together with the accomplishments of DOE's Geothermal R and D Program, ensure that this huge energy resource will play a major role in future U.S. energy markets.

  8. File list: His.PSC.50.H3K9K14ac.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.H3K9K14ac.AllCell hg19 Histone H3K9K14ac Pluripotent stem cell SRX037086... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.H3K9K14ac.AllCell.bed ...

  9. An overview of the contaminant analysis automation program

    International Nuclear Information System (INIS)

    Hollen, R.M.; Erkkila, T.; Beugelsdijk, T.J.

    1992-01-01

    The Department of Energy (DOE) has significant amounts of radioactive and hazardous wastes stored, buried, and still being generated at many sites within the United States. These wastes must be characterized to determine the elemental, isotopic, and compound content before remediation can begin. In this paper, the authors project that sampling requirements will necessitate generating more than 10 million samples by 1995, which will far exceed the capabilities of our current manual chemical analysis laboratories. The Contaminant Analysis Automation effort (CAA), with Los Alamos National Laboratory (LANL) as to the coordinating Laboratory, is designing and fabricating robotic systems that will standardize and automate both the hardware and the software of the most common environmental chemical methods. This will be accomplished by designing and producing several unique analysis systems called Standard Analysis Methods (SAM). Each SAM will automate a specific chemical method, including sample preparation, the analytical analysis, and the data interpretation, by using a building block known as the Standard Laboratory Module (SLM). This concept allows the chemist to assemble an automated environmental method using standardized SLMs easily and without the worry of hardware compatibility or the necessity of generating complicated control programs

  10. The DOE/NASA SRG110 Program Overview

    Science.gov (United States)

    Shaltens, R. K.; Richardson, R. L.

    2005-12-01

    The Department of Energy is developing the Stirling Radioisotope Generator (SRG110) for NASAs Science Mission Directorate for potential surface and deep space missions. The SRG110 is one of two new radioisotope power systems (RPSs) currently being developed for NASA space missions, and is capable of operating in a range of planetary atmospheres and in deep space environments. It has a mass of approximately 27 kg and produces more than 125We(dc) at beginning of mission (BOM), with a design lifetime of fourteen years. Electrical power is produced by two (2) free-piston Stirlings convertor heated by two General Purpose Heat Source (GPHS) modules. The complete SRG110 system is approximately 38 cm x 36 cm and 76 cm long. The SRG110 generator is being designed in 3 stages: Engineering Model, Qualification Generator, and Flight Generator. Current plans call for the Engineering Model to be fabricated and tested by October 2006. Completion of testing of the Qualification Generator is scheduled for mid-2009. This development is being performed by Lockheed Martin, Valley Forge, PA and Infinia Corporation, Kennewick, WA under contract to the Department of Energy, Germantown, Md. Glenn Research Center, Cleveland, Ohio is providing independent testing and support for the technology transition for the SRG110 Program.

  11. Overview of the aerial radiological measuring system (ARMS) program

    International Nuclear Information System (INIS)

    Deal, L.J.; Doyle, J.F. III.

    1975-01-01

    Since 1960 EG and G, Inc. has developed and maintained for the U.S. Energy Research and Development Administration (ERDA) a state-of-the-art radiation surveillance program called the Aerial Radiological Measuring System (ARMS). Radiological surveys covering more than 300,000 square miles have been performed. In addition to the radiation detector gear, the system includes an inertial navigation system, radar altimeter, meteorological probes, air sampler, air sample analyzer, multispectral cameras, aerial mapping camera and infrared scanner. The recently improved data acquisition system, REDAR, records all inputs digitally on magnetic tape and is readily mounted in fixed-wing aircraft or helicopters. The data analysis system, REDAC, is mounted in a mobile processing laboratory which accompanies the aircraft on surveys. Radiation isopleth maps, both for gross counts and selected isotopes, can be prepared in the field. Special computer software enables the ARMS to detect changes of less than 1.0 μR/hr in exposure rates between successive surveys of a given site

  12. An Overview of Recent PISCES Program PMI Results

    Science.gov (United States)

    Tynan, George; Doerner, Russell; Abe, Shota; Baldwin, Matthew; Barton, Joseph; Chen, Renkun; Gosselin, Jordan; Hollmann, Eric; Nishijima, Daisuke; Simmonds, Michael; Wang, Yong; Yu, Jonathan

    2015-11-01

    The PISCES Program is focused on fundamental PMI studies of Be and W-based solid plasma facing components under steady-state and transient conditions. We will show results from studies in W, Be and mixed W-Be material systems. Topics of investigation include formation of near-surface nanobubbles from He plasma ion implantation, growth of W-fuzz from these bubbles in steady-state and transient conditions, D retention in Be and W and development of a D-retention model for both H/D isotope exchange and displacement damage experiments. Initial studies of PMI in displacement damaged W are also presented, showing the effect of damage and exposure temperature on D retention, D diffusion, W thermal conductivity. Be-based results include morphology evolution under high plasma flux exposure, Be erosion mechanisms, and retention in Be-based materials. Future plans and connections to fusion energy system requirements will be discussed. This work supported by grant DE-FG02-07ER54912.

  13. Introduction to Metagenomics at DOE JGI: Program Overview and Program Informatics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Tringe, Susannah

    2011-10-12

    Susannah Tringe of the DOE Joint Genome Institute talks about the Program Overview and Program Informatics at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  14. Overview of the NARSTO-NE-OPS Program

    International Nuclear Information System (INIS)

    Philbrick, C. R.; Ryan, W. F.; Clark, R. D.; Doddridge, B. G; Dickerson, R. R.; Gaffney, J.; Marley, N.; Coulter, R.

    2002-01-01

    The NARSTO-NE-OPS (NorthEast Oxidant and Particle Study) is an investigation of the coupling of the meteorological and chemical processes that control the evolution of air pollution events. The project includes three major field programs carried out at a field site in northeast Philadelphia during the summers of 1998, 1999 and 2001. The activity brings together the research groups from 13 universities, 5 government laboratories and representatives of the electric power industry to apply the most advanced measurement techniques to understanding the physical and chemical processes contributing to air quality issues. Results have been obtained from three ground sites, two instrumented aircraft, many different instrumented balloon platforms, and several remote sensing techniques including satellites. In addition, the database used includes the ground-based measurements conducted at several surrounding state and city operated sites in Pennsylvania, New Jersey, Delaware, New York and Maryland. The results have shown the importance of developing the 3-dimensional regional scale picture of the atmosphere to understand and properly model air pollution events. It has been shown that only from such a perspective, which includes the vertical distribution and a regional context, can one hope to properly model and predict ozone and particulate pollution. A combination of photochemical and dynamical processes transport, both horizontal and vertical, accumulate pollutants that then mix with the locally produced chemical species to cause the more severe episodes of air pollution. Efforts have also focused on developmental testing of several new approaches to improved measuring techniques for better understanding of the physical and chemical properties of the airborne particulate matter

  15. An overview of the waste characterization program at Chalk River Nuclear Laboratories

    International Nuclear Information System (INIS)

    Csullog, G.W.; Hardy, D.G.

    1990-05-01

    A comprehensive Waste Characterization Program (WCP) is in place at Chalk River Laboratories to support disposal projects. The WCP is responsible for: 1) specifying the manifests for waste shipments; 2) developing and maintaining central databases for waste inventories and analytical data; and 3) developing the technologies and procedures to characterize the radiological and the physical/chemical properties of wastes. WCP work is being performed under the umbrella of a newly developed waste management Quality Assurance (QA) program. This paper gives an overview of the WCP with an emphasis on the requirements for determining radionuclide inventories in wastes, for implementing record-keeping systems, and for maintaining a QA program for disposal operations

  16. The Ontario hydro low pressure turbine disc inspection program automated ultrasonic inspection systems - an overview

    International Nuclear Information System (INIS)

    Huggins, J.W.; Chopcian, M.; Grabish, M.

    1990-01-01

    An overview of the Ontario Hydro Low Pressure Turbine Disc Inspection Program is presented. The ultrasonic inspection systems developed in-house to inspect low pressure turbine discs at Pickering and Bruce Nuclear Generating stations are described. Three aspects of the program are covered: PART I - Background to inspection program, disc cracking experience, and development of an in-house inspection capability: PART II - System development requirements; ultrasonic equipment, electromechanical subsystems and instrumentation console: PART III - Customized software for flaw detection, sizing, data acquisition/storage, advanced signal processing, reports, documentation and software based diagnostics

  17. NASA's Radioisotope Power Systems Program Overview - A Focus on RPS Users

    Science.gov (United States)

    Hamley, John A.; McCallum, Peter W.; Sandifer, Carl E., II; Sutliff, Thomas J.; Zakrajsek, June F.

    2016-01-01

    The goal of NASA's Radioisotope Power Systems (RPS) Program is to make RPS ready and available to support the exploration of the solar system in environments where the use of conventional solar or chemical power generation is impractical or impossible to meet potential future mission needs. To meet this goal, the RPS Program manages investments in RPS technologies and RPS system development, working closely with the Department of Energy. This paper provides an overview of the RPS Program content and status, its collaborations with potential RPS users, and the approach employed to maintain the readiness of RPS to support future NASA mission concepts.

  18. TERRAPOWER, LLC TRAVELING WAVE REACTOR DEVELOPMENT PROGRAM OVERVIEW

    Directory of Open Access Journals (Sweden)

    PAVEL HEJZLAR

    2013-11-01

    burden. This paper describes the origins and current status of the TWR development program at TerraPower, LLC. Some of the areas covered include the key TWR design challenges and brief descriptions of TWR-Prototype (TWR-P reactor. Selected information on the TWR-P core designs are also provided in the areas of neutronic, thermal hydraulic and fuel performance. The TWR-P plant design is also described in such areas as; system design descriptions, mechanical design, and safety performance.

  19. An Overview of the NASA Aeronautics Test Program Strategic Plan

    Science.gov (United States)

    Marshall, Timothy J.

    2010-01-01

    U.S. leadership in aeronautics depends on ready access to technologically advanced, efficient, and affordable aeronautics test capabilities. These systems include major wind tunnels and propulsion test facilities and flight test capabilities. The federal government owns the majority of the major aeronautics test capabilities in the United States, primarily through the National Aeronautics and Space Administration (NASA) and the Department of Defense (DoD), however an overarching strategy for management of these national assets was needed. Therefore, in Fiscal Year (FY) 2006 NASA established the Aeronautics Test Program (ATP) as a two-pronged strategic initiative to: (1) retain and invest in NASA aeronautics test capabilities considered strategically important to the agency and the nation, and (2) establish a strong, high level partnership with the DoD Test Resources Management Center (TRMC), stewards of the DoD test and evaluation infrastructure. Since then, approximately seventy percent of the ATP budget has been directed to underpin fixed and variable costs of facility operations within its portfolio and the balance towards strategic investments in its test facilities, including maintenance and capability upgrades. Also, a strong guiding coalition was established through the National Partnership for Aeronautics Testing (NPAT), with governance by the senior leadership of NASA s Aeronautics Research Mission Directorate (ARMD) and the DoD's TRMC. As part of its strategic planning, ATP has performed or participated in many studies and analyses, including assessments of major NASA and DoD aeronautics test capabilities, test facility condition evaluations and market research. The ATP strategy has also benefitted from unpublished RAND research and analysis by Ant n et al. (2009). Together, these various studies, reports and assessments serve as a foundation for a new, five year strategic plan that will guide ATP through FY 2014. Our vision for the future is a balanced

  20. ERRα induces H3K9 demethylation by LSD1 to promote cell invasion

    Science.gov (United States)

    Carnesecchi, Julie; Forcet, Christelle; Zhang, Ling; Tribollet, Violaine; Barenton, Bruno; Boudra, Rafik; Cerutti, Catherine; Billas, Isabelle M. L.; Sérandour, Aurélien A.; Carroll, Jason S.; Beaudoin, Claude; Vanacker, Jean-Marc

    2017-01-01

    Lysine Specific Demethylase 1 (LSD1) removes mono- and dimethyl groups from lysine 4 of histone H3 (H3K4) or H3K9, resulting in repressive or activating (respectively) transcriptional histone marks. The mechanisms that control the balance between these two antagonist activities are not understood. We here show that LSD1 and the orphan nuclear receptor estrogen-related receptor α (ERRα) display commonly activated genes. Transcriptional activation by LSD1 and ERRα involves H3K9 demethylation at the transcriptional start site (TSS). Strikingly, ERRα is sufficient to induce LSD1 to demethylate H3K9 in vitro. The relevance of this mechanism is highlighted by functional data. LSD1 and ERRα coregulate several target genes involved in cell migration, including the MMP1 matrix metallo-protease, also activated through H3K9 demethylation at the TSS. Depletion of LSD1 or ERRα reduces the cellular capacity to invade the extracellular matrix, a phenomenon that is rescued by MMP1 reexpression. Altogether our results identify a regulatory network involving a direct switch in the biochemical activities of a histone demethylase, leading to increased cell invasion. PMID:28348226

  1. ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

    Science.gov (United States)

    Carnesecchi, Julie; Forcet, Christelle; Zhang, Ling; Tribollet, Violaine; Barenton, Bruno; Boudra, Rafik; Cerutti, Catherine; Billas, Isabelle M L; Sérandour, Aurélien A; Carroll, Jason S; Beaudoin, Claude; Vanacker, Jean-Marc

    2017-04-11

    Lysine Specific Demethylase 1 (LSD1) removes mono- and dimethyl groups from lysine 4 of histone H3 (H3K4) or H3K9, resulting in repressive or activating (respectively) transcriptional histone marks. The mechanisms that control the balance between these two antagonist activities are not understood. We here show that LSD1 and the orphan nuclear receptor estrogen-related receptor α (ERRα) display commonly activated genes. Transcriptional activation by LSD1 and ERRα involves H3K9 demethylation at the transcriptional start site (TSS). Strikingly, ERRα is sufficient to induce LSD1 to demethylate H3K9 in vitro. The relevance of this mechanism is highlighted by functional data. LSD1 and ERRα coregulate several target genes involved in cell migration, including the MMP1 matrix metallo-protease, also activated through H3K9 demethylation at the TSS. Depletion of LSD1 or ERRα reduces the cellular capacity to invade the extracellular matrix, a phenomenon that is rescued by MMP1 reexpression. Altogether our results identify a regulatory network involving a direct switch in the biochemical activities of a histone demethylase, leading to increased cell invasion.

  2. The NASA Electronic Parts and Packaging (NEPP) Program: NEPP Overview - Automotive Electronics

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2016-01-01

    The results of NASAs studies into the appropriateness of using U.S. Automotive electronic parts in NASA spaceflight systems will be presented. The first part of the presentation provides an overview of the United States Automotive Electronics Council's AECQ standardization program, the second part provides a summary of the results of NASA's procurement and testing experiences and other lessons learned along with preliminary test results.

  3. Program overview

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    The current status and future plans for gas and glass laser research are described. Some special systems studies described are: (1) power production with laser fusion, (2) laser engineering research facility, and (3) laser isotope separation. (U.S.)

  4. Overview of ORNL/NRC programs addressing durability of concrete structures

    International Nuclear Information System (INIS)

    Naus, D.J.; Oland, C.B.

    1994-01-01

    The role of reinforced concrete relative to its applications as either safety-related structures in nuclear power or engineered barriers of low-level radioactive waste disposal facilities is described. Factors that can affect the long-term durability of reinforced concrete are identified. Overviews are presented of the Structural Aging Program, which is addressing the aging management of safety-related concrete structures in nuclear power plants, and the Permeability Test Methods and Data Program, which is identifying pertinent data and information for use in performance assessments of engineered barriers for low-level radioactive waste disposal

  5. Validation and Development of a Certification Program for Using K9s to Survey Desert Tortoises

    Science.gov (United States)

    2013-08-01

    more of the demonstrations with their dogs: Aimee Hurt with ‘Finney’ and ‘Wicket’, Margaret “Tudy” Morris and ‘Storm’, John Rarity and ‘Kai’, Chris...odor to get the reward. Day 1 – 3 (Sunday, Monday, Tuesday ) With the dog on a 6’ leash and in front of the handler, the handler will give the...Standard Time). 110 TRAINING LOG INFORMATION WEEK ONE - LINEUPS Days 1-3 Sunday, Monday, Tuesday Training Objectives: • Odor

  6. 12-Step Interventions and Mutual Support Programs for Substance Use Disorders: An Overview

    Science.gov (United States)

    Donovan, Dennis M.; Ingalsbe, Michelle H.; Benbow, James; Daley, Dennis C.

    2013-01-01

    Social workers and other behavioral health professionals are likely to encounter individuals with substance use disorders in a variety of practice settings outside of specialty treatment. 12-Step mutual support programs represent readily available, no cost community-based resources for such individuals; however, practitioners are often unfamiliar with such programs. The present article provides a brief overview of 12-Step programs, the positive substance use and psychosocial outcomes associated with active 12-Step involvement, and approaches ranging from ones that can be utilized by social workers in any practice setting to those developed for specialty treatment programs to facilitate engagement in 12-Step meetings and recovery activities. The goal is to familiarize social workers with 12-Step approaches so that they are better able to make informed referrals that match clients to mutual support groups that best meet the individual’s needs and maximize the likelihood of engagement and positive outcomes. PMID:23731422

  7. Overview of nuclear education and outreach program among Malaysian school students

    Science.gov (United States)

    Sahar, Haizum Ruzanna; Masngut, Nasaai; Yusof, Mohd Hafizal; Ngadiron, Norzehan; Adnan, Habibah

    2017-01-01

    This paper gives an overview of nuclear education and outreach program conducted by Agensi Nuklear Malaysia (Nuklear Malaysia) throughout its operation and establishment. Since its foundation in 1972, Nuklear Malaysia has been the pioneer and is competent in the application of nuclear science and technology. Today, Nuklear Malaysia has ventured and eventually contributed into the development of various socio-economic sectors which include but not limited to medical, industry, manufacturing, agriculture, health, radiation safety and environment. This paper accentuates on the history of education and outreach program by Nuklear Malaysia, which include its timeline and evolution; as well as a brief on education and outreach program management, involvement of knowledge management as part of its approach and later the future of Nuklear Malaysia education and outreach program.

  8. Hanford Waste Vitrification Plant quality assurance program description: Overview and applications

    International Nuclear Information System (INIS)

    Caplinger, W.H.

    1990-12-01

    This document describes the Hanford Waste Vitrification Plant Project Quality Assurance Program. This program is being implemented to ensure the acceptability of high-level radioactive canistered waste forms produced by the Hanford Waste Vitrification Plant for disposal in a licensed federal repository. The Hanford Waste Vitrification Plant Quality Assurance Program is comprised of this Quality Assurance Program Description as well as the associated contractors' quality assurance programs. The objective of this Quality Assurance Program Description is to provide the Hanford Waste Vitrification Plant Project participants with guidance and direction for program implementation while satisfying the US Department of Energy Office of Civilian Radioactive Waste Management needs in repository licensing activities with regard to canistered waste forms. To accomplish this objective, this description will be prepared in three parts: Part 1 - Overview and applications document; Part 2 - Development and qualification of the canistered waste form; Part 3 - Production of canistered waste forms. Part 1 describes the background, strategy, application, and content of the Hanford Waste Vitrification Plant Quality Assurance Program. This Quality Assurance Program Description, when complete, is designed to provide a level of confidence in the integrity of the canistered waste forms. 8 refs

  9. File list: His.PSC.20.H3K9ac.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.H3K9ac.AllCell mm9 Histone H3K9ac Pluripotent stem cell SRX185844,SRX185...848,SRX873351,SRX873349,SRX873345,SRX097641,SRX130021,SRX873347,SRX187620 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.H3K9ac.AllCell.bed ...

  10. Overview of a radiation safety program in a district style medical environment

    International Nuclear Information System (INIS)

    Wilson, G.

    2006-01-01

    This paper provides an overview of the eight components of a radiation safety program in a large health care facility spread out over several campuses in a large geographic area in Nova Scotia. The main focus is based on those areas that are regulated by the Canadian Nuclear Safety Commission and generally encompass nuclear medicine and radiation therapy operations. X-ray operations are regulated provincially, but the general operational principles of an effective radiation safety program can be applied in all these areas. The main components covered include the set up of an organizational structure that operates separately from individual departments, general items expected from reports to corporate management or regulators, and some examples of the front-line expectations for those in individual departments. The review is not all encompassing, but should give organizations some insight of the magnitude of a radiation safety program in a district style environment. (author)

  11. A brief overview of NASA Langley's research program in formal methods

    Science.gov (United States)

    1992-01-01

    An overview of NASA Langley's research program in formal methods is presented. The major goal of this work is to bring formal methods technology to a sufficiently mature level for use by the United States aerospace industry. Towards this goal, work is underway to design and formally verify a fault-tolerant computing platform suitable for advanced flight control applications. Also, several direct technology transfer efforts have been initiated that apply formal methods to critical subsystems of real aerospace computer systems. The research team consists of six NASA civil servants and contractors from Boeing Military Aircraft Company, Computational Logic Inc., Odyssey Research Associates, SRI International, University of California at Davis, and Vigyan Inc.

  12. An investigation on 800 nm femtosecond laser ablation of K9 glass in air and vacuum

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Shi-zhen, E-mail: xusz@uestc.edu.cn [School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Yao, Cai-zhen [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Dou, Hong-qiang [Department of Material Science and Engineering, Sichuan Engineering Technical College, Deyang 618000 (China); Liao, Wei, E-mail: liaowei@caep.cn [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Li, Xiao-yang; Ding, Ren-jie [School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Zhang, Li-juan; Liu, Hao; Yuan, Xiao-dong [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Zu, Xiao-tao [School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China)

    2017-06-01

    Highlights: • The fs laser ablation of borosilicate glass (K9) were investigated under 35 and 500 fs pulses. • At high fluence regime, the ablation rate at 35 fs in air increased to a plateau, and 500 fs in air and vacuum decreased. • The mechanisms of multiple-photon ionization and impact ionization were included. • The ablation morphologies of smooth zone and laser-induced periodic surface structures were presented and illustrated. • The ablation mechanisms of non-thermal and thermal ablation were included. - Abstract: Ablation rates of K9 glass were studied as a function of femtosecond laser fluences. The central wavelength was 800 nm, and pulse durations of 35 fs and 500 fs in air and vacuum were employed. Ablation thresholds of 0.42 J/cm{sup 2} and 2.1 J/cm{sup 2} were obtained at 35 fs and 500 fs, respectively, which were independent with the ambient conditions and depend on the incident pulse numbers due to incubation effects. The ablation rate of 35 fs pulse laser increased with the increasing of laser fluence in vacuum, while in air condition, it slowly increased to a plateau at high fluence. The ablation rate of 500 fs pulse laser showed an increase at low fluence and a slow drop of ablation rate was observed at high fluence in air and vacuum, which may due to the strong defocusing effects associated with the non-equilibrium ionization of air, and/or the shielding effects of conduction band electrons (CBEs) produced by multi-photon ionization and impact ionization in K9 glass surface. The typical ablation morphologies, e.g. smooth zone and laser-induced periodic surface structures (LIPSS) were also presented and illustrated.

  13. Genome-wide reduction in H3K9 acetylation during human embryonic stem cell differentiation

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Jana; Uhlířová, Radka; Galiová-Šustáčková, Gabriela; Kozubek, Stanislav; Šmigová, Jana; Bártová, Eva

    2009-01-01

    Roč. 219, č. 3 (2009), s. 677-687 ISSN 0021-9541 R&D Projects: GA MŠk(CZ) LC06027; GA MŠk(CZ) LC535; GA ČR(CZ) GA204/06/0978 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50110509 Keywords : hESC * H3K9 acetylation * epigenetics Subject RIV: BO - Biophysics Impact factor: 4.586, year: 2009

  14. A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

    Energy Technology Data Exchange (ETDEWEB)

    Shan, Chun-Min; Wang, Jiyong; Xu, Ke; Chen, Huijie; Yue, Jia-Xing; Andrews, Stuart; Moresco, James J.; Yates, John R.; Nagy, Peter L.; Tong, Liang; Jia, Songtao

    2016-09-20

    Histone lysine-to-methionine (K-to-M) mutations are associated with multiple cancers, and they function in a dominant fashion to block the methylation of corresponding lysines on wild type histones. However, their mechanisms of function are controversial. Here we show that in fission yeast, introducing the K9M mutation into one of the three histone H3 genes dominantly blocks H3K9 methylation on wild type H3 across the genome. In addition, H3K9M enhances the interaction of histone H3 tail with the H3K9 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 is trapped at nucleation sites to prevent its spreading and the formation of large heterochromatin domains. We further determined the crystal structure of an H3K9M peptide in complex with human H3K9 methyltransferase G9a and SAM, which reveales that the methionine side chain had enhanced van der Waals interactions with G9a. Therefore, our results provide a detailed mechanism by which H3K9M regulates H3K9 methylation.

  15. Environmental program overview for a high-level radioactive waste repository at Yucca Mountain

    International Nuclear Information System (INIS)

    1988-12-01

    The United States plans to begin operating the first repository for the permanent disposal of high-level nuclear waste early in the next century. In February 1983, the US Department of Energy (DOE) identified Yucca Mountain, in Nevada, as one of nine potentially acceptable sites for a repository. To determine its suitability, the DOE evaluated the Yucca Mountain site, along with eight other potentially acceptable sites, in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The purpose of the Environmental Program Overview (EPO) for the Yucca Mountain site is to provide an overview of the overall, comprehensive approach being used to satisfy the environmental requirements applicable to sitting a repository at Yucca Mountain. The EPO states how the DOE will address the following environmental areas: aesthetics, air quality, cultural resources (archaeological and Native American components), noise, radiological studies, soils, terrestrial ecosystems, and water resources. This EPO describes the environmental program being developed for the sitting of a repository at Yucca Mountain. 1 fig., 3 tabs

  16. Observation of photoelectrons of magnetic conjugate point with the rocket K-9M-54

    International Nuclear Information System (INIS)

    Mukai, Toshinori; Hirao, Kunio

    1976-01-01

    The results of the observation of photoelectrons with the rocket K-9M-54 are described. The instrument used for the observation has been reported elsewhere, and it is a low energy electron spectrometer. The angle of direction of the collimator of the detector was 30 degrees to the spin axis of the rocket. Variation of the electric potential was large. The rocket K-9M-54 took off on January 17, 1976, at six o'clock. The finally attained altitude of the rocket was about 366 km. The solar zenith angles were 106 degrees at Uchinoura and 94 degrees at the magnetic conjugate point. The UV shadow heights were 361 km at Uchinoura and 116 km at the magnetic conjugate point. The distribution of the pitch angle was observed, and was almost isotropic. The altitude variation of the integrated flux is shown in a figure, and it shows remarkable difference between the present result and the previous ones observed in day-time. The relations between energy and photoelectron flux at various altitudes were obtained. The characteristic features of the energy distribution were similar to those of the spectra observed in day-time. (Kato, T.)

  17. Food and nutrition programs for Aboriginal and Torres Strait Islander Australians: an overview of systematic reviews.

    Science.gov (United States)

    Browne, Jennifer; Adams, Karen; Atkinson, Petah; Gleeson, Deborah; Hayes, Rick

    2017-09-19

    Objective To provide an overview of previous reviews of programs that aimed to improve nutritional status or diet-related health outcomes for Aboriginal and Torres Strait Islander peoples, in order to determine what programs are effective and why. Methods A systematic search of databases and relevant websites was undertaken to identify reviews of nutrition interventions for Aboriginal and Torres Strait Islander Australians. Pairs of reviewers undertook study selection and data extraction and performed quality assessment using a validated tool. Results Twelve papers reporting 11 reviews were identified. Two reviews were rated high quality, three were rated medium and six were rated low quality. The reviews demonstrated that a positive effect on nutrition and chronic disease indicators can be a result of: 1) incorporating nutrition and breastfeeding advice into maternal and child health care services; and 2) multifaceted community nutrition programs. The evidence suggests that the most important factor determining the success of Aboriginal and Torres Strait Islander food and nutrition programs is community involvement in (and, ideally, control of) program development and implementation. Conclusions Community-directed food and nutrition programs, especially those with multiple components that address the underlying causes of nutrition issues, can be effective in improving nutrition-related outcomes. What is known about the topic? More effective action is urgently required in order to reduce the unacceptable health inequalities between Aboriginal and Torres Strait Islander peoples and non-Indigenous Australians. Food insecurity and nutrition-related chronic conditions are responsible for a large proportion of the ill health experienced by Australia's First Peoples. What does this paper add? This narrative overview of 11 reviews published between 2005 and 2015 provides a synthesis of the current evidence for improving Aboriginal and Torres Strait Islander nutrition

  18. Overview of the US Department of Energy Light Water Reactor Sustainability Program

    International Nuclear Information System (INIS)

    McCarthy, K.A.; Williams, D.L.; Reister, R.

    2012-01-01

    The US Department of Energy Light Water Reactor Sustainability (LWRS) Program is focused on enabling the long-term operation of US commercial power plants. Decisions on life extension will be made by commercial power plant owners - the information provided by the research and development activities in the LWRS Program will reduce the uncertainty (and therefore the risk) associated with making those decisions. The LWRS Program encompasses two facets of long-term operation: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the nuclear industry that support implementation of performance improvement technologies. An important aspect of the Light Water Reactor Sustainability Program is partnering with industry and the Nuclear Regulatory Commission to support and conduct the long-term research needed to inform major component refurbishment and replacement strategies, performance enhancements, plant license extensions, and age-related regulatory oversight decisions. The Department of Energy research, development, and demonstration role focuses on aging phenomena and issues that require long-term research and/or unique Department of Energy laboratory expertise and facilities and are applicable to all operating reactors. This paper provides an overview of the Department of Energy Light Water Reactor Sustainability Program, including vision, goals, and major deliverables. (author)

  19. Motor-operated Valve Program at NPP Krsko (NEK) - Status and Overview

    International Nuclear Information System (INIS)

    Nikolic, M; Jagodar, N.; Cerjak, J.; Butkovic, V.

    2002-01-01

    On the basics of US NRC Generic Letter 89-10 Safety-related Motor-operated Valve Testing and Surveillance and subsequent generic letters, Motor-operated Valve (MOV) Program at NEK has been developing. Namely, the holders of nuclear power plant operating licenses has to verify the design basis capability of safety-related e.g. important-to-safety MOVs, as well as to ensure the same for the life of the plant. In light of that, each plant should establish a program to address stressed issues for each program MOV (124 at NEK). Such comprehensive task requires significant effort in many aspects, and basically multidisciplinary skills. NEK MOV Program represents a blend of engineering and in-plant testing, comprised of three phases: Phase I Engineering, Phase II Field Implementation and Phase III Trending. Currently, the program is about the end of Phase I and II, as well as in development of engineering basis for launching Phase III. Overview of the major programmatic issues will be given in this paper along with ongoing activities: testing process, gear-ratio modification, pressure locking/thermal binding susceptibility screening and preventive maintenance. (author)

  20. Conversion of research and test reactors to low enriched uranium fuel: technical overview and program status

    International Nuclear Information System (INIS)

    Roglans-Ribas, J.

    2008-01-01

    Many of the nuclear research and test reactors worldwide operate with high enriched uranium fuel. In response to worries over the potential use of HEU from research reactors in nuclear weapons, the U.S Department of Energy (DOE) initiated a program - the Reduced Enrichment for Research and Test Reactors (RERTR) - in 1978 to develop the technology necessary to reduce the use of HEU fuel by converting research reactors to low enriched uranium (LEU) fuel. The Reactor Conversion program is currently under the DOE's National Nuclear Security Administration's Global Threat Reduction Initiative (GTRI). 55 of the 129 reactors included in the scope have been already converted to LEU fuel or have shutdown prior to conversion. The major technical activities of the Conversion Program include: (1) the development of advanced LEU fuels; (2) conversion analysis and conversion support; and (3) technology development for the production of Molybdenum-99 (Mo 99 ) with LEU targets. The paper provides an overview of the status of the program, the technical challenges and accomplishments, and the role of international collaborations in the accomplishment of the Conversion Program objectives. Nuclear research and test reactors worldwide have been in operation for over 60 years. Many of these facilities operate with high enriched uranium fuel. In response to increased worries over the potential use of HEU from research reactors in the manufacturing of nuclear weapons, the U.S Department of Energy (DOE) initiated a program - the Reduced Enrichment for Research and Test Reactors (RERTR) - in 1978 to develop the technology necessary to reduce the use of HEU fuel in research reactors by converting them to low enriched uranium (LEU) fuel. The reactor conversion program was initially focused on U.S.-supplied reactors, but in the early 1990s it expanded and began to collaborate with Russian institutes with the objective of converting Russian supplied reactors to the use of LEU fuel.

  1. Overview of GNSS-R Research Program for Ocean Observations at Japan

    Science.gov (United States)

    Ichikawa, Kaoru; Ebinuma, Takuji; Akiyama, Hiroaki; Kitazawa, Yukihito

    2015-04-01

    GNSS-R is a new remote-sensing method which uses reflected GNSS signals. Since no transmitters are required, it is suitable for small satellites. Constellations of GNSS-R small satellites have abilities on revolutionary progress on 'all-time observable' remote-sensing methods . We have started a research program for GNSS-R applications on oceanographic observations under a contract with MEXT (Ministry of Education Culture, Sports, Science and Technology, JAPAN) as a'Space science research base formation program'. The duration of research program is 3 years (2015-2017). The one of important focuses of this program is creation of a new community to merge space engineering and marine science through establishment on application plans of GNSS-R. Actual GNSS-R data acquisition experiments using multi-copters, ships, and/or towers are planned, together with in-situ sea truth data such as wave spectrum, wind speed profiles and sea surface height. These data are compared to determine the accuracy and resolution of the estimates based on GNSS-R observations. Meanwhile, preparation of a ground station for receiving GNSS-R satellite data will be also established. Whole those data obtained in this project will be distributed for public. This paper introduces the overview of research plan..

  2. Observation of solar HLy-α by K-9M-59 rocket

    International Nuclear Information System (INIS)

    Watanabe, Norihiko; Tono, Ichiro; Koshio, Takafumi.

    1978-01-01

    The purpose of the observation is to measure the illumination intensity of solar HLy-α (1216 A) and the altitude distribution of O 2 density in earth atmosphere. Since solar HLy-α is strongly absorbed by O 2 in the earth atmosphere, the extinction of HLy-α depends on the altitude distribution of O 2 density. The K-9M-59 rocket was launched on September 3, 1977. The HLy-α detector was a narrow-band ion chamber filled with NO gas. The result showed that the solar HLy-α irradiance at the rocket altitude of 90 km was 3.5 x 10 11 photons/cm 2 s and the altitude distribution of O 2 density was obtained. (Yoshimori, M.)

  3. Early Childhood Caries and the Impact of Current U.S. Medicaid Program: An Overview

    Directory of Open Access Journals (Sweden)

    Bussma Ahmed Bugis

    2012-01-01

    Full Text Available Pediatric dental caries is the most common chronic disease among children. Above 40% of the U.S. children aged 2–11 years have dental caries; more than 50% of them come from low-income families. Under dental services of the Medicaid program, children enrolled in Medicaid must receive preventive dental services. However, only 1/5 of them utilize preventive dental services. The purpose of this overview is to measure the impact of Medicaid dental benefits on reducing oral health disparities among Medicaid-eligible children. This paper explains the importance of preventive dental care, children at high risk of dental caries, Medicaid dental benefits, utilization of dental preventive services by Medicaid-eligible children, dental utilization influencing factors, and outcome evaluation of Medicaid in preventing dental caries among children. In conclusion, despite the recent increase of children enrolled in Medicaid, utilizing preventive dental care is still a real challenge that faces Medicaid.

  4. Overview of graduate training program of John Adams Institute for Accelerator Science

    Science.gov (United States)

    Seryi, Andrei

    The John Adams Institute for Accelerator Science is a center of excellence in the UK for advanced and novel accelerator technology, providing expertise, research, development and training in accelerator techniques, and promoting advanced accelerator applications in science and society. We work in JAI on design of novel light sources upgrades of 3-rd generation and novel FELs, on plasma acceleration and its application to industrial and medical fields, on novel energy recovery compact linacs and advanced beam diagnostics, and many other projects. The JAI is based on three universities - University of Oxford, Imperial College London and Royal Holloway University of London. Every year 6 to 10 accelerators science experts, trained via research on cutting edge projects, defend their PhD thesis in JAI partner universities. In this presentation we will overview the research and in particular the highly successful graduate training program in JAI.

  5. Overview of NASA's Universe of Learning: An Integrated Astrophysics STEM Learning and Literacy Program

    Science.gov (United States)

    Smith, Denise; Lestition, Kathleen; Squires, Gordon; Biferno, Anya A.; Cominsky, Lynn; Manning, Colleen; NASA's Universe of Learning Team

    2018-01-01

    NASA's Universe of Learning creates and delivers science-driven, audience-driven resources and experiences designed to engage and immerse learners of all ages and backgrounds in exploring the universe for themselves. The project is the result of a unique partnership between the Space Telescope Science Institute, Caltech/IPAC, Jet Propulsion Laboratory, Smithsonian Astrophysical Observatory, and Sonoma State University, and is one of 27 competitively-selected cooperative agreements within the NASA Science Mission Directorate STEM Activation program. The NASA's Universe of Learning team draws upon cutting-edge science and works closely with Subject Matter Experts (scientists and engineers) from across the NASA Astrophysics Physics of the Cosmos, Cosmic Origins, and Exoplanet Exploration themes. Together we develop and disseminate data tools and participatory experiences, multimedia and immersive experiences, exhibits and community programs, and professional learning experiences that meet the needs of our audiences, with attention to underserved and underrepresented populations. In doing so, scientists and educators from the partner institutions work together as a collaborative, integrated Astrophysics team to support NASA objectives to enable STEM education, increase scientific literacy, advance national education goals, and leverage efforts through partnerships. Robust program evaluation is central to our efforts, and utilizes portfolio analysis, process studies, and studies of reach and impact. This presentation will provide an overview of NASA's Universe of Learning, our direct connection to NASA Astrophysics, and our collaborative work with the NASA Astrophysics science community.

  6. An overview of the Nuclear Electric Propulsion Space Test Program (NEPSTP) satellite

    International Nuclear Information System (INIS)

    Voss, S.S.; Reynolds, E.L.

    1994-01-01

    Early in 1992 the idea of purchasing a Russian designed and fabricated space reactor power system and integrating it with a US designed satellite went from fiction to reality with the purchase of the first two Topaz II reactors by the Strategic Defense Initiative Organization (now the Ballistic Missile Defense Organization (BMDO)). The New Mexico Alliance was formed to establish a ground test facility in which to perform nonnuclear systems testing of the Topaz II, and to evaluate the Topaz II system for flight testing with respect to safety, performance, and operability. In conjunction, SDIO requested that the Applied Physics Laboratory in Laurel, MD propose a mission and design a satellite in which the Topaz II could be used as the power source. The outcome of these two activities was the design of the Nuclear Electric Propulsion Space Test Program (NEPSTP) satellite which combines a modified Russian Topaz II power system with a US designed satellite to achieve a specified mission. Due to funding reduction within the SDIO, the Topaz II flight program was postponed indefinitely at the end of Fiscal year 1993. The purpose of this paper is to present an overview of the NEPSTP mission and the satellite design at the time the flight program ended

  7. An overview of the waste characterization program at Chalk River Nuclear Laboratories

    International Nuclear Information System (INIS)

    Csullog, G.W.; Hardy, D.G.

    1988-01-01

    In the last five years, Chalk River Nuclear Laboratories (CRNL) placed 17,000 m 3 of wastes into storage (excluding contaminated soil and fill). Almost half of the waste was generated off-site. CRNL is now developing IRUS, an Intrusion Resistant Underground Structure, and the IST, an Improved Sand Trench, to replace storage with safe, permanent disposal. IRUS will be used to dispose of wastes with radiologically hazardous lifetimes between 150 and 500 years duration and the IST will be used for wastes with radiologically hazardous lifetimes of less than 150 years. A comprehensive Waste Characterization Program (WCP) is in place to support disposal projects. The WCP is responsible for (1) specifying the manifests for waste shipments; (2) developing and maintaining central databases for waste inventories and analytical data; and (3) developing the technologies and procedures to characterize the radiological and the physical/chemical properties of wastes. WCP work is being performed under the umbrella of a newly developed waste management quality assurance (QA) program. This paper gives an overview of the WCP with an emphasis on the requirements for determining radionuclide inventories in wastes, for implementing record-keeping systems and for maintaining a QA program for disposal operations

  8. Overview of the Education and Public Outreach (EPO) program of the Caltech Tectonics Observatory

    Science.gov (United States)

    Kovalenko, L.; Jain, K.; Maloney, J.

    2009-12-01

    The Caltech Tectonics Observatory (TO) is an interdisciplinary center, focused on geological processes occurring at the boundaries of Earth's tectonic plates (http://www.tectonics.caltech.edu). Over the past year, the TO has made a major effort to develop an Education and Public Outreach (EPO) program. Our goals are to (1) stimulate the interest of students and the general public in Earth Sciences, particularly in the study of tectonic processes, (2) inform and educate the general public about science in the context of TO discoveries and advancements, and (3) provide opportunities for graduate students, postdocs, and faculty to do outreach in the local K-12 schools. We have hosted local high school students and teachers to provide them with research experience (as part of Caltech’s “Summer Research Connection”); participated in teacher training workshops (organized by the local school district); hosted tours for local elementary school students; and brought hands-on activities into local elementary and middle school classrooms, science clubs, and science nights. We have also led local school students and teachers on geology field trips through nearby parks. In addition, we have developed education modules for undergraduate classes (as part of MARGINS program), and have written educational web articles on TO research (http://www.tectonics.caltech.edu/outreach). The presentation will give an overview of these activities and their impact on our educational program.

  9. Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects

    OpenAIRE

    Balan, Shabeesh; Iwayama, Yoshimi; Maekawa, Motoko; Toyota, Tomoko; Ohnishi, Tetsuo; Toyoshima, Manabu; Shimamoto, Chie; Esaki, Kayoko; Yamada, Kazuo; Iwata, Yasuhide; Suzuki, Katsuaki; Ide, Masayuki; Ota, Motonori; Fukuchi, Satoshi; Tsujii, Masatsugu

    2014-01-01

    Background Histone H3 methylation at lysine 9 (H3K9) is a conserved epigenetic signal, mediating heterochromatin formation by trimethylation, and transcriptional silencing by dimethylation. Defective GLP (Ehmt1) and G9a (Ehmt2) histone lysine methyltransferases, involved in mono and dimethylation of H3K9, confer autistic phenotypes and behavioral abnormalities in animal models. Moreover, EHMT1 loss of function results in Kleefstra syndrome, characterized by severe intellectual disability, dev...

  10. Super Energy Savings Performance Contracts: Federal Energy Management Program (FEMP) Program Overview (revision)

    International Nuclear Information System (INIS)

    Pitchford, P.

    2001-01-01

    This four-page publication describes the U.S. Department of Energy's (DOE's) streamlined energy savings performance contracting, or ''Super ESPC,'' process, which is managed by DOE's Federal Energy Management Program (FEMP). Under a Super ESPC, a qualifying energy service company (ESCO) from the private sector pays for energy efficiency improvements or advanced renewable energy technologies (e.g., photovoltaic systems, wind turbines, or geothermal heat pumps, among others) for a facility of a government agency. The ESCO is then repaid over time from the agency's resulting energy cost savings. Delivery orders under these contracts specify the level of performance (energy savings) and the repayment schedule; the contract term can be up to 25 years, although many Super ESPCs are for about 10 years or less

  11. PKL/K9, Refill and Reflood Experiment in a Simulated PWR Primary System (PKL)

    International Nuclear Information System (INIS)

    1981-01-01

    1 - Description of test facility: PKL-facility simulates the essential primary system components of a typical West German 1300 PWR with regard to their thermohydraulic behaviour. The facility essentially consists of the pressure vessel with the heated bundle, the downcomer simulator, the primary loops with the components steam generator and pump simulator, the injection devices, the break geometry simulator, as well as the separators connected thereto, and the test containment to maintain a back-pressure at the location of break which is expected to be typical for emergency conditions. The number of heater rods and the cross-sections of the testing plant are on a reduced scale 1:134 in comparison with a typical German PWR. The elevations and locations are essentially full scale. Pressure vessel: The space between the pressure vessel and the inner core casing is sealed from the core region and the upper and lower plenum and connected with the upper plenum only by a pressure equalization line. The rod bundle surrounded by the inner core casing consists of 340 rods, 337 of which are indirect electrically heated. The test bundle cross-section as well as a heater element with the measuring elevations, the original-KWU-spacers and the axial power profile (7 power steps) are described. Downcomer: The downcomer is simulated by the downcomer nozzle region and the downcomer U-tube. The cold leg injection takes place both directly in the downcomer nozzle region and in the lines of t he intact single and double loop near to the downcomer nozzle region. A cylindrical insertion and repulsing metal sheets are installed in the downcomer nozzle region in order to avoid the emergency injection points into the broken loop. 2 - Description of test: Test K 9 out of a series PKL-IB was conducted on May 30, 1979 by Kraftwerk Union (KWU) at Erlangen (Germany). The objective of the integral cold leg injection test K 9 (double-ended 200%-break) was to investigate after a LOCA the refill and

  12. Disability Overview

    Science.gov (United States)

    ... About CDC.gov . Disability & Health Home Disability Overview Disability Inclusion Barriers to Inclusion Inclusion Strategies Inclusion in Programs & Activities Resources Healthy Living Disability & Physical Activity Disability & Obesity Disability & Smoking Disability & Breast ...

  13. Overview of the joint US/Russia surety program in the Sandia National Laboratories Cooperative Measures Program

    International Nuclear Information System (INIS)

    Smith, R.E.; Vorontsova, O.S.; Blinov, I.M.

    1998-02-01

    Sandia National Laboratories has initiated many joint research and development projects with the two premier Russian nuclear laboratories, VNIIEF and VNIITF, (historically known as Arzamas-16 and Chelyabinsk-70) in a wide spectrum of areas. One of the areas in which critical dialogue and technical exchange is continuing to take place is in the realm of system surety. Activities primarily include either safety or security methodology development, processes, accident environment analyses and testing, accident data-bases, assessments, and product design. Furthermore, a continuing dialog has been established between the organizations with regard to developing a better understanding of how risk is perceived and analyzed in Russia versus that in the US. The result of such efforts could reduce the risk of systems to incur accidents or incidents resulting in high consequences to the public. The purpose of this paper is to provide a current overview of the Sandia surety program and its various initiatives with the Russian institutes, with an emphasis on the program scope and rationale. The historical scope of projects will be indicated. A few specific projects will be discussed, along with results to date. The extension of the joint surety initiatives to other government and industry organizations will be described. This will include the current status of a joint Sandia/VNIIEF initiative to establish an International Surety Center for Energy Intensive and High Consequence Systems and Infrastructures

  14. NRC review of passive reactor design certification testing programs: Overview and regulatory perspective

    International Nuclear Information System (INIS)

    Levin, A.E.

    1993-01-01

    Reactor vendors are developing new designs for future deployment, including open-quotes passiveclose quotes light water reactors (LWRs), such as General Electric's (G.E.'s) simplified boiling water reactor (SBWR) and Westinghouse's AP600, which depend primarily on inherent processes, such as national convection and gravity feed, for safety injection and emergency core cooling. The U.S. Nuclear Regulatory Commission (NRC) has implemented a new process, certification of standardized reactor designs, for licensing these Plants. Part 52 of Title 10 of the Code of Federal Regulations (10CFR52) contains the requirements that vendors must meet for design certification. One important section, 10CFR52.47, reads open-quotes Certification of a standard design which . . . utilizes simplified, inherent, passive, or other innovative means to accomplish its safety functions will be granted only if: (1) The performance of each safety feature of the design has been demonstrated through either analysis, appropriate test programs, experience, or a combination thereof; (2) Interdependent effects among the safety features have been found acceptable by analysis, appropriate test programs, experience, or a combination thereof; and (3) Sufficient data exist on the safety features of the design to assess the analytical tools used for safety analyses. . . . The vendors have initiated programs to test innovative features of their designs and to develop data bases needed to validate their analytical codes, as required by the design certification rule. Accordingly, the NRC is reviewing and evaluating the vendors programs to ensure that they address adequately key issues concerning safety system performance. This paper provides an overview of the NRC's review process and regulatory perspective

  15. Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a

    International Nuclear Information System (INIS)

    Zhang, Xi; Wu, Jianguo; Choiniere, Jonathan; Yang, Zhihong; Huang, Yi; Bennett, Jason; Wang, Li

    2016-01-01

    It is well established that increased liver cancer incidence is strongly associated with epigenetic silencing of tumor suppressor genes; the latter is contributed by the environmental exposure to arsenic. Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle. However, the epigenetic mechanisms mediated by arsenic to control PDK4 expression remain elusive. In the present study, we showed that histone methyltransferase G9a- and Suv39H-mediated histone H3 lysine 9 (H3K9) methylations contributed to PDK4 silencing in hepatic cells. The PDK4 expression was induced by G9a inhibitor BRD4770 (BRD) and Suv39H inhibitor Chaetocin (CHA). In contrast, arsenic exposure decreased PDK4 expression by inducing G9a and increasing H3K9 di- and tri-methylations levels (H3K9me2/3). In addition, arsenic exposure antagonizes the effect of BRD by enhancing the enrichment of H3K9me2/3 in the PKD4 promoter. Moreover, knockdown of G9a using siRNA induced PDK4 expression in HCC cells. Furthermore, arsenic decreased hepatic PDK4 expression as well as diminished the induction of PDK4 by BRD in mouse liver and hepatocytes. Overall, the results suggest that arsenic causes aberrant repressive histone modification to silence PDK4 in both HCC cells and in mouse liver. - Graphical abstract: Schematic showing arsenic-mediated epigenetic pathway that inhibits PDK4 expression. (A) BRD induces PDK4 expression by decreasing G9a protein and histone H3K9me2 and H3K9me3 levels as well as diminishing their recruitment to the PDK4 promoter. (B) Arsenic counteracts the effect of BRD by increasing histone H3K9me2 and H3K9me3 levels as well as enhancing their enrichment to the PDK4 promoter. Display Omitted - Highlights: • Histone methyltrasferase G9a inhibitor BRD induces PDK4 expression. • Arsenic decreases PDK4 expression and increases H3K9me2 and me3 levels. • Arsenic enhances H3K9me2/me3 enrichment in the PDK4 promoter. • Arsenic antagonizes the activation of

  16. Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xi; Wu, Jianguo; Choiniere, Jonathan [Department of Physiology and Neurobiology and The Institute for Systems Genomics, University of Connecticut, Storrs, CT 062696 (United States); Yang, Zhihong [Department of Physiology and Neurobiology and The Institute for Systems Genomics, University of Connecticut, Storrs, CT 062696 (United States); Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516 (United States); Huang, Yi [Department of Physiology and Neurobiology and The Institute for Systems Genomics, University of Connecticut, Storrs, CT 062696 (United States); School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035 (China); Bennett, Jason [Department of Physiology and Neurobiology and The Institute for Systems Genomics, University of Connecticut, Storrs, CT 062696 (United States); Wang, Li, E-mail: li.wang@uconn.edu [Department of Physiology and Neurobiology and The Institute for Systems Genomics, University of Connecticut, Storrs, CT 062696 (United States); Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516 (United States); School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035 (China); Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06520 (United States)

    2016-08-01

    It is well established that increased liver cancer incidence is strongly associated with epigenetic silencing of tumor suppressor genes; the latter is contributed by the environmental exposure to arsenic. Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle. However, the epigenetic mechanisms mediated by arsenic to control PDK4 expression remain elusive. In the present study, we showed that histone methyltransferase G9a- and Suv39H-mediated histone H3 lysine 9 (H3K9) methylations contributed to PDK4 silencing in hepatic cells. The PDK4 expression was induced by G9a inhibitor BRD4770 (BRD) and Suv39H inhibitor Chaetocin (CHA). In contrast, arsenic exposure decreased PDK4 expression by inducing G9a and increasing H3K9 di- and tri-methylations levels (H3K9me2/3). In addition, arsenic exposure antagonizes the effect of BRD by enhancing the enrichment of H3K9me2/3 in the PKD4 promoter. Moreover, knockdown of G9a using siRNA induced PDK4 expression in HCC cells. Furthermore, arsenic decreased hepatic PDK4 expression as well as diminished the induction of PDK4 by BRD in mouse liver and hepatocytes. Overall, the results suggest that arsenic causes aberrant repressive histone modification to silence PDK4 in both HCC cells and in mouse liver. - Graphical abstract: Schematic showing arsenic-mediated epigenetic pathway that inhibits PDK4 expression. (A) BRD induces PDK4 expression by decreasing G9a protein and histone H3K9me2 and H3K9me3 levels as well as diminishing their recruitment to the PDK4 promoter. (B) Arsenic counteracts the effect of BRD by increasing histone H3K9me2 and H3K9me3 levels as well as enhancing their enrichment to the PDK4 promoter. Display Omitted - Highlights: • Histone methyltrasferase G9a inhibitor BRD induces PDK4 expression. • Arsenic decreases PDK4 expression and increases H3K9me2 and me3 levels. • Arsenic enhances H3K9me2/me3 enrichment in the PDK4 promoter. • Arsenic antagonizes the activation of

  17. MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance.

    Science.gov (United States)

    Lev, Itamar; Seroussi, Uri; Gingold, Hila; Bril, Roberta; Anava, Sarit; Rechavi, Oded

    2017-04-24

    In C. elegans, alterations to chromatin produce transgenerational effects, such as inherited increase in lifespan and gradual loss of fertility. Inheritance of histone modifications can be induced by double-stranded RNA-derived heritable small RNAs. Here, we show that the mortal germline phenotype, which is typical of met-2 mutants, defective in H3K9 methylation, depends on HRDE-1, an argonaute that carries small RNAs across generations, and is accompanied by accumulated transgenerational misexpression of heritable small RNAs. We discovered that MET-2 inhibits small RNA inheritance, and, as a consequence, induction of RNAi in met-2 mutants leads to permanent RNAi responses that do not terminate even after more than 30 generations. We found that potentiation of heritable RNAi in met-2 animals results from global hyperactivation of the small RNA inheritance machinery. Thus, changes in histone modifications can give rise to drastic transgenerational epigenetic effects, by controlling the overall potency of small RNA inheritance. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function.

    Science.gov (United States)

    Bergmann, Jan H; Jakubsche, Julia N; Martins, Nuno M; Kagansky, Alexander; Nakano, Megumi; Kimura, Hiroshi; Kelly, David A; Turner, Bryan M; Masumoto, Hiroshi; Larionov, Vladimir; Earnshaw, William C

    2012-01-15

    Human kinetochores are transcriptionally active, producing very low levels of transcripts of the underlying alpha-satellite DNA. However, it is not known whether kinetochores can tolerate acetylated chromatin and the levels of transcription that are characteristic of housekeeping genes, or whether kinetochore-associated 'centrochromatin', despite being transcribed at a low level, is essentially a form of repressive chromatin. Here, we have engineered two types of acetylated chromatin within the centromere of a synthetic human artificial chromosome. Tethering a minimal NF-κB p65 activation domain within kinetochore-associated chromatin produced chromatin with high levels of histone H3 acetylated on lysine 9 (H3K9ac) and an ~10-fold elevation in transcript levels, but had no substantial effect on kinetochore assembly or function. By contrast, tethering the herpes virus VP16 activation domain produced similar modifications in the chromatin but resulted in an ~150-fold elevation in transcripts, approaching the level of transcription of an endogenous housekeeping gene. This rapidly inactivated kinetochores, causing a loss of assembled CENP-A and blocking further CENP-A assembly. Our data reveal that functional centromeres in vivo show a remarkable plasticity--kinetochores tolerate profound changes to their chromatin environment, but appear to be critically sensitive to the level of centromeric transcription.

  19. Molecular Targets of Chromatin Repressive Mark H3K9me3 in Primate Progenitor Cells within Adult Neurogenic Niches

    Directory of Open Access Journals (Sweden)

    Michael R Foret

    2014-07-01

    Full Text Available Histone 3 Lysine 9 (H3K9 methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3 is enriched in an adult neural stem cell niche- the subventricular zone (SVZ on the walls of the lateral ventricle in both rodent and non-human primate baboon brain. Previous studies have shown that there is significant correlation between baboon and human regarding genomic similarity and brain structure, suggesting that findings in baboon are relevant to human. To understand the function of H3K9me3 in this adult neurogenic niche, we performed genome-wide analyses using ChIP-Seq (chromatin immunoprecipitation and deep-sequencing and RNA-Seq for in vivo SVZ cells purified from baboon brain. Through integrated analyses of ChIP-Seq and RNA-Seq, we found that H3K9me3-enriched genes associated with cellular maintenance, post-transcriptional and translational modifications, signaling pathways, and DNA replication are expressed, while genes involved in axon/neuron, hepatic stellate cell, or immune-response activation are not expressed. As neurogenesis progresses in the adult SVZ, cell fate restriction is essential to direct proper lineage commitment. Our findings highlight that H3K9me3 repression in undifferentiated SVZ cells is engaged in the maintenance of cell type integrity, implicating a role for H3K9me3 as an epigenetic mechanism to control cell fate transition within this adult germinal niche.

  20. Fundamental Aeronautics Program: Overview of Project Work in Supersonic Cruise Efficiency

    Science.gov (United States)

    Castner, Raymond

    2011-01-01

    The Supersonics Project, part of NASA?s Fundamental Aeronautics Program, contains a number of technical challenge areas which include sonic boom community response, airport noise, high altitude emissions, cruise efficiency, light weight durable engines/airframes, and integrated multi-discipline system design. This presentation provides an overview of the current (2011) activities in the supersonic cruise efficiency technical challenge, and is focused specifically on propulsion technologies. The intent is to develop and validate high-performance supersonic inlet and nozzle technologies. Additional work is planned for design and analysis tools for highly-integrated low-noise, low-boom applications. If successful, the payoffs include improved technologies and tools for optimized propulsion systems, propulsion technologies for a minimized sonic boom signature, and a balanced approach to meeting efficiency and community noise goals. In this propulsion area, the work is divided into advanced supersonic inlet concepts, advanced supersonic nozzle concepts, low fidelity computational tool development, high fidelity computational tools, and improved sensors and measurement capability. The current work in each area is summarized.

  1. Fundamental Aeronautics Program: Overview of Propulsion Work in the Supersonic Cruise Efficiency Technical Challenge

    Science.gov (United States)

    Castner, Ray

    2012-01-01

    The Supersonics Project, part of NASA's Fundamental Aeronautics Program, contains a number of technical challenge areas which include sonic boom community response, airport noise, high altitude emissions, cruise efficiency, light weight durable engines/airframes, and integrated multi-discipline system design. This presentation provides an overview of the current (2012) activities in the supersonic cruise efficiency technical challenge, and is focused specifically on propulsion technologies. The intent is to develop and validate high-performance supersonic inlet and nozzle technologies. Additional work is planned for design and analysis tools for highly-integrated low-noise, low-boom applications. If successful, the payoffs include improved technologies and tools for optimized propulsion systems, propulsion technologies for a minimized sonic boom signature, and a balanced approach to meeting efficiency and community noise goals. In this propulsion area, the work is divided into advanced supersonic inlet concepts, advanced supersonic nozzle concepts, low fidelity computational tool development, high fidelity computational tools, and improved sensors and measurement capability. The current work in each area is summarized.

  2. Astrochemical evolution along star formation: Overview of the IRAM Large Program ASAI

    Science.gov (United States)

    Lefloch, Bertrand; Bachiller, R.; Ceccarelli, C.; Cernicharo, J.; Codella, C.; Fuente, A.; Kahane, C.; López-Sepulcre, A.; Tafalla, M.; Vastel, C.; Caux, E.; González-García, M.; Bianchi, E.; Gómez-Ruiz, A.; Holdship, J.; Mendoza, E.; Ospina-Zamudio, J.; Podio, L.; Quénard, D.; Roueff, E.; Sakai, N.; Viti, S.; Yamamoto, S.; Yoshida, K.; Favre, C.; Monfredini, T.; Quitián-Lara, H. M.; Marcelino, N.; Roberty, H. Boechat; Cabrit, S.

    2018-04-01

    Evidence is mounting that the small bodies of our Solar System, such as comets and asteroids, have at least partially inherited their chemical composition from the first phases of the Solar System formation. It then appears that the molecular complexity of these small bodies is most likely related to the earliest stages of star formation. It is therefore important to characterize and to understand how the chemical evolution changes with solar-type protostellar evolution. We present here the Large Program "Astrochemical Surveys At IRAM" (ASAI). Its goal is to carry out unbiased millimeter line surveys between 80 and 272 GHz of a sample of ten template sources, which fully cover the first stages of the formation process of solar-type stars, from prestellar cores to the late protostellar phase. In this article, we present an overview of the surveys and results obtained from the analysis of the 3 mm band observations. The number of detected main isotopic species barely varies with the evolutionary stage and is found to be very similar to that of massive star-forming regions. The molecular content in O- and C- bearing species allows us to define two chemical classes of envelopes, whose composition is dominated by either a) a rich content in O-rich complex organic molecules, associated with hot corino sources, or b) a rich content in hydrocarbons, typical of Warm Carbon Chain Chemistry sources. Overall, a high chemical richness is found to be present already in the initial phases of solar-type star formation.

  3. Commercial Building Energy Asset Score Program Overview and Technical Protocol (Version 1.1)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Goel, Supriya; Makhmalbaf, Atefe

    2013-08-09

    The U.S. Department of Energy (DOE) is developing a voluntary national scoring system for commercial buildings to help building owners and managers assess a building’s energy-related systems independent of operations. The goal of the score is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system, known as the Commercial Building Energy Asset Score, will allow building owners and managers to compare their building infrastructure against peers and track building upgrades over time. The system will also help other building stakeholders (e.g., building investors, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset scoring tool. The alternative methods that were considered prior to developing the current approach are described in the Program Overview and Technical Protocol Version 1.0.

  4. An Overview of the NASA Aviation Safety Program Propulsion Health Monitoring Element

    Science.gov (United States)

    Simon, Donald L.

    2000-01-01

    The NASA Aviation Safety Program (AvSP) has been initiated with aggressive goals to reduce the civil aviation accident rate, To meet these goals, several technology investment areas have been identified including a sub-element in propulsion health monitoring (PHM). Specific AvSP PHM objectives are to develop and validate propulsion system health monitoring technologies designed to prevent engine malfunctions from occurring in flight, and to mitigate detrimental effects in the event an in-flight malfunction does occur. A review of available propulsion system safety information was conducted to help prioritize PHM areas to focus on under the AvSP. It is noted that when a propulsion malfunction is involved in an aviation accident or incident, it is often a contributing factor rather than the sole cause for the event. Challenging aspects of the development and implementation of PHM technology such as cost, weight, robustness, and reliability are discussed. Specific technology plans are overviewed including vibration diagnostics, model-based controls and diagnostics, advanced instrumentation, and general aviation propulsion system health monitoring technology. Propulsion system health monitoring, in addition to engine design, inspection, maintenance, and pilot training and awareness, is intrinsic to enhancing aviation propulsion system safety.

  5. Stress relaxation damage in K9 glass plate irradiated by 1.06μm CW laser

    International Nuclear Information System (INIS)

    Luo Fu; Sun Chengwei

    2001-01-01

    Based on the stress relaxation model in 1D planar geometry and the visco-elastic constitutive equation, the temperature and stress histories in the K9 glass samples irradiated by CW laser beams (λ = 1.06 μm) have been calculated. The results indicate that the residual tensile stress due to the stress relaxation effect during cooling after the laser radiation may be greater than the tensile fracture strength of samples, while the maximum compression stress during the laser heating is less than the requirement for compression damage. For a K9 glass window of 3 mm thickness, its damage due to the stress relaxation may be induced by a laser radiation of 0.946 MW/cm 2 for 0.2s . Therefore, the stress relaxation should be regarded as the main mechanism of damage in K9 glass windows while a CW laser beam (λ = 1.06 μm) irradiates it with large spot

  6. An overview of a 5-year research program on acid deposition in China

    Science.gov (United States)

    Wang, T.; He, K.; Xu, X.; Zhang, P.; Bai, Y.; Wang, Z.; Zhang, X.; Duan, L.; Li, W.; Chai, F.

    2011-12-01

    Despite concerted research and regulative control of sulfur dioxide in China, acid rain remained a serious environmental issue, due to a sharp increase in the combustion of fossil fuel in the 2000s. In 2005, the Ministry of Science and Technology of China funded a five-year comprehensive research program on acid deposition. This talk will give an overview of the activities and the key findings from this study, covering emission, atmospheric processes, and deposition, effects on soil and stream waters, and impact on typical trees/plants in China. The main results include (1) China still experiences acidic rainfalls in southern and eastern regions, although the situation has stabilized after 2006 due to stringent control of SO2 by the Chinese Government; (2) Sulfate is the dominant acidic compound, but the contribution of nitrate has increased; (3) cloud-water composition in eastern China is strongly influenced by anthropogenic emissions; (4) the persistent fall of acid rain in the 30 years has lead to acidification of some streams/rivers and soils in southern China; (5) the studied plants have shown varying response to acid rain; (6) some new insights have been obtained on atmospheric chemistry, atmospheric transport, soil chemistry, and ecological impacts, some of which will be discussed in this talk. Compared to the situation in North America and Europe, China's acid deposition is still serious, and continued control of sulfur and nitrogen emission is required. There is an urgent need to establish a long-term observation network/program to monitor the impact of acid deposition on soil, streams/rivers/lakes, and forests.

  7. The Soreq Applied Research Accelerator Facility (SARAF): Overview, research programs and future plans

    Science.gov (United States)

    Mardor, Israel; Aviv, Ofer; Avrigeanu, Marilena; Berkovits, Dan; Dahan, Adi; Dickel, Timo; Eliyahu, Ilan; Gai, Moshe; Gavish-Segev, Inbal; Halfon, Shlomi; Hass, Michael; Hirsh, Tsviki; Kaiser, Boaz; Kijel, Daniel; Kreisel, Arik; Mishnayot, Yonatan; Mukul, Ish; Ohayon, Ben; Paul, Michael; Perry, Amichay; Rahangdale, Hitesh; Rodnizki, Jacob; Ron, Guy; Sasson-Zukran, Revital; Shor, Asher; Silverman, Ido; Tessler, Moshe; Vaintraub, Sergey; Weissman, Leo

    2018-05-01

    The Soreq Applied Research Accelerator Facility (SARAF) is under construction in the Soreq Nuclear Research Center at Yavne, Israel. When completed at the beginning of the next decade, SARAF will be a user facility for basic and applied nuclear physics, based on a 40 MeV, 5 mA CW proton/deuteron superconducting linear accelerator. Phase I of SARAF (SARAF-I, 4 MeV, 2 mA CW protons, 5 MeV 1 mA CW deuterons) is already in operation, generating scientific results in several fields of interest. The main ongoing program at SARAF-I is the production of 30 keV neutrons and measurement of Maxwellian Averaged Cross Sections (MACS), important for the astrophysical s-process. The world leading Maxwellian epithermal neutron yield at SARAF-I (5 × 10^{10} epithermal neutrons/s), generated by a novel Liquid-Lithium Target (LiLiT), enables improved precision of known MACSs, and new measurements of low-abundance and radioactive isotopes. Research plans for SARAF-II span several disciplines: precision studies of beyond-Standard-Model effects by trapping light exotic radioisotopes, such as 6He, 8Li and 18, 19, 23Ne, in unprecedented amounts (including meaningful studies already at SARAF-I); extended nuclear astrophysics research with higher energy neutrons, including generation and studies of exotic neutron-rich isotopes relevant to the rapid (r-) process; nuclear structure of exotic isotopes; high energy neutron cross sections for basic nuclear physics and material science research, including neutron induced radiation damage; neutron based imaging and therapy; and novel radiopharmaceuticals development and production. In this paper we present a technical overview of SARAF-I and II, including a description of the accelerator and its irradiation targets; a survey of existing research programs at SARAF-I; and the research potential at the completed facility (SARAF-II).

  8. Fuel cell program - Overview reports 2007; Programm Brennstoffzellen inkl. Wasserstoff - Ueberblicksberichte der BFE-Programmleiter 2007

    Energy Technology Data Exchange (ETDEWEB)

    Luzzi, A.; Spirig, M.

    2008-07-01

    This report for the Swiss Federal Office of Energy (SFOE) presents the overview reports made by SFOE Heads of Program on work done in 2007. Projects reported on in the natural gas-fired fuel cell area include the EU-project REAL-SFOC, the long-term testing of anode-supported SOFC stacks, intermediate-temperature fuel cells based on proton conducting electrolytes, the interdisciplinary ONEBAT project and lifetime-enhancement of SOFC stacks for CHP applications. In the polymer-electrolyte fuel cell (PEFC) area, projects concerning proton-conducting polymer membranes, factors limiting the lifetime of fuel cell membranes, a new highly active oxygen reduction electrode for PEM fuel cell and zinc/air battery applications, the enhancement of PEFC durability and reliability, model-based investigation of PEFC performance, and local gas analysis of PE fuel cells are briefly reported on. Long-term research activities in the hydrogen technology area reported on include those concerning the photo-chemical conversion and storage of solar energy and the storage of hydrogen in metallic and complex hydrides. Further projects reported on include those concerning the physical aspects of hydrides for system integration and safety and new, complex metal hydrides. Swiss national and international co-ordination is reviewed in the areas of fuel cell technology and hydrogen technology. Work done in several projects run within the framework of the IEA's Advanced Fuel Cells Program is reviewed. Several pilot and demonstration (P and D) projects are also reported on in the natural-gas SOFC and PEFC areas. Comments on the 2007 results and a review of work to be done in 2008, along with a list of R, D, P and D projects, complete the report.

  9. Overview of the unified program of the scaling factor determination program and the dose to curie conversion program

    International Nuclear Information System (INIS)

    Lee, Sang Chul; Hwang, Ki Ha; Lee, Kun Jai; Kim, Tae Wook; Kim, Kyoung Doek; Song, Myung Jae

    2005-01-01

    Final disposal of radioactive waste generated from Nuclear Power Plant (NPP) requires the information of the radionuclides inventories in waste package by national regulations and guidelines. However, the direct assessment through the destruction of the drummed radioactive waste for all stored drums is difficult economically and time-consuming. KAIST developed the program for the SF determination method based on the database for the activity of the each selected nuclide analyzed by KAERI using the statistical method such as log mean average (LMA) generally and the theoretical method for some fission nuclides. To improve the reliability of the SF calculated by the program, two methods have been applied. The first method is the calculation of scaling factor by grouping the waste type or plant type of the database set. The other method is the calculation of SF after the outlier of the database is eliminated

  10. Thermochemistry in BWR. An overview of applications of program codes and databases

    International Nuclear Information System (INIS)

    Hermansson, H-P.; Becker, R.

    2010-01-01

    The Swedish work on thermodynamics of metal-water systems relevant to BWR conditions has been ongoing since the 70ies, and at present time a compilation and adaptation of codes and thermodynamic databases are in progress. In the previous work, basic thermodynamic data were compiled for parts of the system Fe-Cr-Ni-Co-Zn-S-H 2 O at 25-300 °C. Since some thermodynamic information necessary for temperature extrapolations of data up to 300 °C was not published in the earlier works, these data have now been partially recalculated. This applies especially to the parameters of the HKF-model, which are used to extrapolate the thermodynamic data for ionic and neutral aqua species from 25 °C to BWR temperatures. Using the completed data, e.g. the change in standard Gibbs energy (ΔG 0 ) and the equilibrium constant (log K) can be calculated for further applications at BWR/LWR conditions. In addition a computer program is currently being developed at Studsvik for the calculation of equilibrium conductivity in high temperature water. The program is intended for PWR applications, but can also be applied to BWR environment. Data as described above will be added to the database of this program. It will be relatively easy to further develop the program e.g. to calculate Pourbaix diagrams, and these graphs could then be calculated at any temperature. This means that there will be no limitation to the temperatures and total concentrations (usually 10 -6 to 10 -8 mol/kg) as reported in earlier work. It is also easy to add a function generating ΔG 0 and log K values at selected temperatures. One of the fundamentals for this work was also to overview and collect publicly available thermodynamic program codes and databases of relevance for BWR conditions found in open sources. The focus has been on finding already done compilations and reviews, and some 40 codes and 15 databases were found. Codes and data-bases are often integrated and such a package is often developed for

  11. Assessing Costs and Benefits of Early Childhood Intervention Programs. Overview and Applicaton to the Starting Early Starting Smart Program

    National Research Council Canada - National Science Library

    Karoly, Lynn

    2001-01-01

    Agency and program administrators and decisionmakers responsible for implementing early childhood intervention programs are becoming more interested in quantifying the costs and benefits of such programs...

  12. Changing Curriculum: A Critical Inquiry into the Revision of the British Columbia Science Curriculum For Grades K-9

    Science.gov (United States)

    Searchfield, Mary A.

    In 2010 British Columbia's Ministry of Education started the process of redesigning the provincial school curriculum, Kindergarten to Grade 12. Mandatory implementation of the new curriculum was set for the 2016/17 school year for Grades K-9, and 2017/18 for Grades 10-12. With a concerted emphasis on personalized learning and through the frame of a Know-Do-Understand curriculum model, the new curriculum aims to meet the needs of today's learners, described as living in a technology-rich, fast-paced and ever-changing world, through a concept-based and competency-driven emphasis. This thesis is a critical analysis of the BC K-9 Science curriculum as written and published, looking specifically at how science is treated as a form of knowledge, its claimed presentation as a story, and on whether the intentions claimed by the designers are matched in the curriculum's final form.

  13. A role for repressive complexes and H3K9 di-methylation in PRDM5-associated brittle cornea syndrome

    DEFF Research Database (Denmark)

    Porter, Louise F; Galli, Giorgio G; Williamson, Sally

    2015-01-01

    skin fibroblasts and retinal tissue from BCS2 patients, to elucidate the epigenetic role of PRDM5 and mechanisms of its dysregulation in disease.First we report abnormal retinal vascular morphology in the eyes of two cousins with BCS2 (PRDM5 Δ exons 9-14) using immunohistochemistry, and mine data from......, and dysregulated H3K9 di-methylation in skin fibroblasts of three patients (p.Arg590*, p.Glu134* and Δ exons 9-14) by western blotting. These findings suggest that defective interaction of PRDM5 with repressive complexes, and dysregulation of H3K9 di-methylation, play a role in PRDM5-associated disease.......Type 2 brittle cornea syndrome (BCS2) is an inherited connective tissue disease with a devastating ocular phenotype caused by mutations in the transcription factor PRDM5 hypothesised to exert epigenetic effects through histone and DNA methylation. Here we investigate clinical samples, including...

  14. JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Sihui Li

    2018-04-01

    Full Text Available Summary: The arginine methylation status of histones dynamically changes during many cellular processes, including hematopoietic stem/progenitor cell (HSPC development. The arginine methyltransferases and the readers that transduce the histone codes have been defined. However, whether arginine demethylation actively occurs in cells and what enzyme demethylates the methylarginine residues during various cellular processes are unknown. We report that JMJD1B, previously identified as a lysine demethylase for H3K9me2, mediates arginine demethylation of H4R3me2s and its intermediate, H4R3me1. We show that demethylation of H4R3me2s and H3K9me2s in promoter regions is correlated with active gene expression. Furthermore, knockout of JMJD1B blocks demethylation of H4R3me2s and/or H3K9me2 at distinct clusters of genes and impairs the activation of genes important for HSPC differentiation and development. Consequently, JMJD1B−/− mice show defects in hematopoiesis. Altogether, our study demonstrates that demethylase-mediated active arginine demethylation process exists in eukaryotes and that JMJD1B demethylates both H4R3me2s and H3K9me2 for epigenetic programming during hematopoiesis. : Li et al. identify the arginine demethylase (RDM activity of JMJD1B, a known lysine demethylase (KDM. They reveal that JMJD1B actively mediates demethylation of histone markers H4R3me2s and H3K9me2 in hematopoietic stem/progenitor cells (HSPCs. Keywords: JMJD1B, KDM3B, PRMT5, arginine demethylase, histone, epigenetic programming, gene expression, hematopoiesis

  15. 75 FR 24671 - Office of Innovation and Improvement; Overview Information; Promise Neighborhoods Program

    Science.gov (United States)

    2010-05-05

    ...) in title I schools. Prepared for the U.S. Department of Education. Available January 2010 online at... University, 2004. \\8\\ Institute for Education Sciences. Status and Trends in the Education of American... DEPARTMENT OF EDUCATION Office of Innovation and Improvement; Overview Information; Promise...

  16. Overview of the TCV tokamak program: scientific progress and facility upgrades.

    Czech Academy of Sciences Publication Activity Database

    Coda, S.; Ficker, Ondřej; Horáček, Jan; Papřok, Richard

    2017-01-01

    Roč. 57, October (2017), č. článku 102011. ISSN 0029-5515 EU Projects: European Commission(XE) 633053 - EUROfusion Institutional support: RVO:61389021 Keywords : TCV * tokamak * overview Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 3.307, year: 2016

  17. 75 FR 67705 - Office of Postsecondary Education; Overview Information; Talent Search (TS) Program; Notice...

    Science.gov (United States)

    2010-11-03

    ... DEPARTMENT OF EDUCATION Office of Postsecondary Education; Overview Information; Talent Search (TS... currently being served by a Talent Search project, especially schools that the State has identified as the... reliable third-party sources when providing information on the implementation of their Talent Search...

  18. An overview of heat exchanger technology in the Canadian nuclear program

    International Nuclear Information System (INIS)

    Carlucci, L.N.; Dalrymple, D.G.; Ko, P.L.; Pathania, R.; Pettigrew, M.I.; Scott, D.A.

    1981-06-01

    This paper provides an overview of the Canadian approach to the reliability and serviceability of heat exchange equipment used in nuclear power stations and heavy water plants. Current work in vibration and fretting predictions, thermal-hydraulic analyses, and corrosion research is described. Procedures developed for in-service inspection, in situ tube replacment and chemical cleaning of corrosion products are also outlined

  19. An Overview of the WIN Program: Its Objectives, Accomplishments, and Problems.

    Science.gov (United States)

    Comptroller General of the U.S., Washington, DC.

    The Work Incentive (WIN) program is supposed to help recipients of Aid to Families with Dependent Children (AFDC) to get jobs through a program of training, work experience, and employment while reducing the cost of the AFDC program. Because of concerns raised about the program, the Government Accounting Office (GAO) assessed the program to…

  20. Pre-analytical variables of circulating cell-free nucleosomes containing 5-methylcytosine DNA or histone modification H3K9Me3

    DEFF Research Database (Denmark)

    Rasmussen, Louise; Herzog, Marielle; Rømer, Eva

    2016-01-01

    Aim: To evaluate pre-analytical variables of circulating cell-free nucleosomes containing 5-methylcytosine DNA (5mC) or histone modification H3K9Me3 (H3K9Me3). Materials and methods: Six studies were designed to assess the possible influence of pre-analytical variables. Study 1: influence of stasis...... significantly lower levels of 5mC or H3K9Me3 compared to levels in healthy individuals. Conclusion: Levels of 5mC or H3K9Me3 appear stable in most pre-analytical settings if blood samples are stored at room temperature until centrifugation....

  1. An overview of the status of nuclear science education in pre-college programs

    International Nuclear Information System (INIS)

    Ling, A.C.; Atwood, C.H.

    1993-01-01

    This communication will provide an overview of the papers given in the Symposium entitled 'Pre-College Education in Nuclear Science' held under the auspices of the Division of Nuclear Chemistry and Technology of the American Chemical Society, and given at the 204th National Meeting of the American Chemical Society in Washington, D.C., on August 24-28, 1992. The Symposium consisted of 45 invited papers, and covered topics in nuclear science education at the high school, middle school, and elementary school levels. The Symposium also presented an overview of the involvement of university and federal laboratories in providing teaching and research opportunities for pre-college faculty and students, curriculum enhancement by special interest groups such as power and utility companies, as well as funding opportunities from private and federal agencies. (author)

  2. Pilot program: NRC severe reactor accident incident response training manual. Overview and summary of major points

    International Nuclear Information System (INIS)

    McKenna, T.J.; Martin, J.A. Jr.; Giitter, J.G.; Miller, C.W.; Hively, L.M.; Sharpe, R.W.; Watkins

    1987-02-01

    Overview and Summary of Major Points is the first in a series of volumes that collectively summarize the U.S. Nuclear Regulatory Commission (NRC) emergency response during severe power reactor accidents and provide necessary background information. This volume describes elementary perspectives on severe accidents and accident assessment. Other volumes in the series are: Volume 2-Severe Reactor Accident Overview; Volume 3- Response of Licensee and State and Local Officials; Volume 4-Public Protective Actions-Predetermined Criteria and Initial Actions; Volume 5 - U.S. Nuclear Regulatory Commission. Each volume serves, respectively, as the text for a course of instruction in a series of courses for NRC response personnel. These materials do not provide guidance or license requirements for NRC licensees. The volumes have been organized into these training modules to accommodate the scheduling and duty needs of participating NRC staff. Each volume is accompanied by an appendix of slides that can be used to present this material

  3. Linking Shorebird Conservation and Education Along Flyways: An Overview of the Shorebird Sister Schools Program

    Science.gov (United States)

    Hillary Chapman; Heather Johnson

    2005-01-01

    The Shorebird Sister Schools Program (SSSP) is an internet-based environmental education program that provides a forum for students, biologists, and shorebird enthusiasts to track shorebird migration and share observations along flyways. The program?s vision is to engage public participation in the conservation of shorebirds and their wetland, grassland, and shoreline...

  4. Mexico; Financial Sector Assessment Program Update: Technical Note: Derivatives Market: Overview and Potential Vulnerabilities

    OpenAIRE

    International Monetary Fund

    2007-01-01

    This technical note provides an overview of Mexico’s derivatives markets, and describes concisely the derivatives regulatory framework and risk management practices in financial institutions active in these markets. The most important derivatives market in Mexico is the over-the-counter (OTC) derivatives market, which is fully integrated with the global derivatives market. The origin of the OTC derivatives market can be traced back to the 1994 Mexican crisis that forced Mexico to abandon its ...

  5. Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation

    International Nuclear Information System (INIS)

    Ding, Donglin; Qu, Xiying; Li, Lin; Zhou, Xin; Liu, Sijie; Lin, Shiguan; Wang, Pengfei; Liu, Shaohui; Kong, Chuijin; Wang, Xiaohui; Liu, Lin; Zhu, Huanzhang

    2013-01-01

    Understanding the mechanism of HIV-1 latency is crucial to eradication of the viral reservoir in HIV-1-infected individuals. However, the role of histone methyltransferase (HMT) G9a-like protein (GLP) in HIV-1 latency is still unclear. In the present work, we established four clonal cell lines containing HIV-1 vector. We found that the integration sites of most clonal cell lines favored active gene regions. However, we also observed hypomethylation of CpG of HIV 5′LTR in all four clonal cell lines. Additionally, 5′-deoxy-5′-methylthioadenosine (MTA), a broad-spectrum histone methyltransferase inhibitor, was used to examine the role of histone methylation in HIV-1 latency. MTA was found to decrease the level of H3K9 dimethylation, causing reactivation of latent HIV-1 in C11 cells. GLP knockdown by small interfering RNA clearly induced HIV-1 LTR expression. Results suggest that GLP may play a significant role in the maintenance of HIV-1 latency by catalyzing dimethylation of H3K9. - Highlights: ► We have established an in vitro model of HIV-1 latency. ► The integration sites of most clonal cell lines favor in active gene regions. ► Hypomethylation occurs in CpG islands of HIV 5′LTR in all four clonal cell lines. ► MTA can reactivate latent HIV-1 by decreasing the level of H3K9 me2 in C11 cells. ► HMT GLP may play a significant role in the maintenance of HIV-1 latency

  6. H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases

    DEFF Research Database (Denmark)

    Hansen, Klavs R; Hazan, Idit; Shanker, Sreenath

    2011-01-01

    organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic histone marks to the properties of heterochromatin remain largely undefined. Here, we report that silencing of the fission yeast mating-type cassettes, which are located in a well......, our results point to histone deacetylases as prominent repressors of gene expression in fission yeast heterochromatin. These deacetylases can act in concert with, or independently of, the widely studied H3K9me mark to influence gene silencing at heterochromatic loci....

  7. An Overview and Funding History of Select Department of Justice (DOJ) Grant Programs

    National Research Council Canada - National Science Library

    James, Nathan

    2006-01-01

    ...), and the Office of Violence Against Women, provide grant funds to state, local, and tribal governments for crime prevention and intervention programs as well as funding for criminal justice system improvement programs...

  8. 26 CFR 301.6103(k)(9)-1 - Disclosure of returns and return information relating to payment of tax by credit card and debit...

    Science.gov (United States)

    2010-04-01

    ... relating to payment of tax by credit card and debit card. 301.6103(k)(9)-1 Section 301.6103(k)(9)-1... Disclosure of returns and return information relating to payment of tax by credit card and debit card... processing credit card and debit card transactions to effectuate payment of tax as authorized by § 301.6311-2...

  9. A Healthy Lifestyle Program for Latino Daughters and Mothers: The BOUNCE Overview and Process Evaluation

    Science.gov (United States)

    Olvera, Norma N.; Knox, Brook; Scherer, Rhonda; Maldonado, Gabriela; Sharma, Shreela V.; Alastuey, Lisa; Bush, Jill A.

    2008-01-01

    Background: Few family-based healthy lifestyle programs for Latinos have been conducted, especially family programs targeting mother-daughter dyads. Purpose: To assess the acceptability and feasibility of the Behavior Opportunities Uniting Nutrition Counseling and Exercise (BOUNCE) program designed for Latino mother-daughter pairs. Methods: 92…

  10. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  11. Overview of the U.S. inspection capability demonstration program for CRDM penetrations

    International Nuclear Information System (INIS)

    Melton, M.; Whitaker, D.; Ammirato, F.; Pathania, R.

    1994-01-01

    The US PWR Owners have developed a coordinated program to demonstrate the effectiveness of procedures for inspection of the Control Rod Drive Mechanism (CRDM) nozzle penetrations. The purpose of the inspections is to detect inside surface Primary Water Stress Corrosion Cracking (PWSCC). Reactor vessel manufacturers, PWR Owners Groups, and EPRI are participating in this cooperative program. Flaw detection, sizing, and location capability will be assessed in the program using realistic full-scale mockups containing intentional defects. The program is expected to be completed by January 1, 1994 and be available for qualification work at that time. The demonstration program is scheduled to become operational in 1993 to support 1994 and future inspections

  12. A critical overview of industrial energy decoupling programs in six developing countries in Asia

    International Nuclear Information System (INIS)

    Luken, Ralph A.; Piras, Stefano

    2011-01-01

    In reviewing the journal literature on the decoupling of energy use and industrial output in the Asian region, particularly with respect to developing countries, we found little information about most country programs other than for China and India and only one article that compared the programs of these two countries. For this reason, we used diverse sources to identify the key programmatic features that have contributed, but clearly are not totally responsible for, decoupling achievements of two countries ( China and Thailand) and then, on the basis of these findings, reviewed emerging industrial energy decoupling programs in four other countries (India, Indonesia, Malaysia and Vietnam). We found that the design of the two successful on-going decoupling programs have common features, which are setting an explicit target for decoupling of energy use and industrial output, a government program that offers financial incentives and imposes specific auditing and reporting requirements and involvement of the manufacturing sector in designing and implementing targets as they apply to individual enterprises. We also found that the emerging programs in the other four countries lack some or all of these essential programmatic features. - Highlights: → We reviewed two on-going and four emerging industrial energy decoupling programs. → These six Asian developing countries have very different rates of decoupling. → The two successful on-going programs share three common features. → These are quantitative targets, supportive programs and industry involvement. → The four emerging programs lack some or all of these features.

  13. Program definition and assessment overview. [for thermal energy storage project management

    Science.gov (United States)

    Gordon, L. H.

    1980-01-01

    The implementation of a program level assessment of thermal energy storage technology thrusts for the near and far term to assure overall coherent energy storage program is considered. The identification and definition of potential thermal energy storage applications, definition of technology requirements, and appropriate market sectors are discussed along with the necessary coordination, planning, and preparation associated with program reviews, workshops, multi-year plans and annual operating plans for the major laboratory tasks.

  14. An overview of the Douglas Aircraft Company Aeroelastic Design Optimization Program (ADOP)

    Science.gov (United States)

    Dodd, Alan J.

    1989-01-01

    From a program manager's viewpoint, the history, scope and architecture of a major structural design program at Douglas Aircraft Company called Aeroelastic Design Optimization Program (ADOP) are described. ADOP was originally intended for the rapid, accurate, cost-effective evaluation of relatively small structural models at the advanced design level, resulting in improved proposal competitiveness and avoiding many costly changes later in the design cycle. Before release of the initial version in November 1987, however, the program was expanded to handle very large production-type analyses.

  15. Cook It Up! A community-based cooking program for at-risk youth: overview of a food literacy intervention

    Directory of Open Access Journals (Sweden)

    Thomas Heather MC

    2011-11-01

    Full Text Available Abstract Background In Canada, there are limited occasions for youth, and especially at-risk youth, to participate in cooking programs. The paucity of these programs creates an opportunity for youth-focused cooking programs to be developed, implemented, and evaluated with the goal of providing invaluable life skills and food literacy to this potentially vulnerable group. Thus, an 18-month community-based cooking program for at-risk youth was planned and implemented to improve the development and progression of cooking skills and food literacy. Findings This paper provides an overview of the rationale for and implementation of a cooking skills intervention for at-risk youth. The manuscript provides information about the process of planning and implementing the intervention as well as the evaluation plan. Results of the intervention will be presented elsewhere. Objectives of the intervention included the provision of applied food literacy and cooking skills education taught by local chefs and a Registered Dietitian, and augmented with fieldtrips to community farms to foster an appreciation and understanding of food, from 'gate to plate'. Eight at-risk youth (five girls and three boys, mean age = 14.6 completed the intervention as of November 2010. Pre-test cooking skills assessments were completed for all participants and post-test cooking skills assessments were completed for five of eight participants. Post intervention, five of eight participants completed in-depth interviews about their experience. Discussion The Cook It Up! program can provide an effective template for other agencies and researchers to utilize for enhancing existing programs or to create new applied cooking programs for relevant vulnerable populations. There is also a continued need for applied research in this area to reverse the erosion of cooking skills in Canadian society.

  16. In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level

    Science.gov (United States)

    Park, Insun; Hwang, Yu Jin; Kim, TaeHun; Viswanath, Ambily Nath Indu; Londhe, Ashwini M.; Jung, Seo Yun; Sim, Kyoung Mi; Min, Sun-Joon; Lee, Ji Eun; Seong, Jihye; Kim, Yun Kyung; No, Kyoung Tai; Ryu, Hoon; Pae, Ae Nim

    2017-10-01

    ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3). SETDB1/ESET leads to heterochromatin condensation and epigenetic gene silencing. These functional changes are reported to correlate with Huntington's disease (HD) progression and mood-related disorders which make SETDB1/ESET a viable drug target. In this context, the present investigation was performed to identify novel peptide-competitive small molecule inhibitors of the SETDB1/ESET by a combined in silico-in vitro approach. A ligand-based pharmacophore model was built and employed for the virtual screening of ChemDiv and Asinex database. Also, a human SETDB1/ESET homology model was constructed to supplement the data further. Biological evaluation of the selected 21 candidates singled out 5 compounds exhibiting a notable reduction of the H3K9me3 level via inhibitory potential of SETDB1/ESET activity in SETDB1/ESET-inducible cell line and HD striatal cells. Later on, we identified two compounds as final hits that appear to have neuronal effects without cytotoxicity based on the result from MTT assay. These compounds hold the calibre to become the future lead compounds and can provide structural insights into more SETDB1/ESET-focused drug discovery research. Moreover, these SETDB1/ESET inhibitors may be applicable for the preclinical study to ameliorate neurodegenerative disorders via epigenetic regulation.

  17. In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level.

    Science.gov (United States)

    Park, Insun; Hwang, Yu Jin; Kim, TaeHun; Viswanath, Ambily Nath Indu; Londhe, Ashwini M; Jung, Seo Yun; Sim, Kyoung Mi; Min, Sun-Joon; Lee, Ji Eun; Seong, Jihye; Kim, Yun Kyung; No, Kyoung Tai; Ryu, Hoon; Pae, Ae Nim

    2017-10-01

    ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3). SETDB1/ESET leads to heterochromatin condensation and epigenetic gene silencing. These functional changes are reported to correlate with Huntington's disease (HD) progression and mood-related disorders which make SETDB1/ESET a viable drug target. In this context, the present investigation was performed to identify novel peptide-competitive small molecule inhibitors of the SETDB1/ESET by a combined in silico-in vitro approach. A ligand-based pharmacophore model was built and employed for the virtual screening of ChemDiv and Asinex database. Also, a human SETDB1/ESET homology model was constructed to supplement the data further. Biological evaluation of the selected 21 candidates singled out 5 compounds exhibiting a notable reduction of the H3K9me3 level via inhibitory potential of SETDB1/ESET activity in SETDB1/ESET-inducible cell line and HD striatal cells. Later on, we identified two compounds as final hits that appear to have neuronal effects without cytotoxicity based on the result from MTT assay. These compounds hold the calibre to become the future lead compounds and can provide structural insights into more SETDB1/ESET-focused drug discovery research. Moreover, these SETDB1/ESET inhibitors may be applicable for the preclinical study to ameliorate neurodegenerative disorders via epigenetic regulation.

  18. Pilot program: NRC severe reactor accident incident response training manual: Severe reactor accident overview

    International Nuclear Information System (INIS)

    McKenna, T.J.; Martin, J.A.; Miller, C.W.; Hively, L.M.; Sharpe, R.W.; Giitter, J.G.; Watkins, R.M.

    1987-02-01

    This pilot training manual has been written to fill the need for a general text on NRC response to reactor accidents. The manual is intended to be the foundation for a course for all NRC response personnel. Severe Reactor Accident Overview is the second in a series of volumes that collectively summarize the US Nuclear Regulatory Commission (NRC) emergency response during severe power reactor accidents and provide necessary background information. This volume describes elementary perspectives on severe accidents and accident assesment. Each volume serves, respectively, as the text for a course of instruction in a series of courses. Each volume is accompanied by an appendix of slides that can be used to present this material. The slides are called out in the text

  19. Integrated Worker Health Protection and Promotion Programs: Overview and Perspectives on Health and Economic Outcomes

    Science.gov (United States)

    Pronk, Nicolaas P.

    2014-01-01

    Objective To describe integrated worker health protection and promotion (IWHPP) program characteristics, to discuss the rationale for integration of OSH and WHP programs, and to summarize what is known about the impact of these programs on health and economic outcomes. Methods A descriptive assessment of the current state of the IWHPP field and a review of studies on the effectiveness of IWHPP programs on health and economic outcomes. Results Sufficient evidence of effectiveness was found for IWHPP programs when health outcomes are considered. Impact on productivity-related outcomes is considered promising, but inconclusive, whereas insufficient evidence was found for health care expenditures. Conclusions Existing evidence supports an integrated approach in terms of health outcomes but will benefit significantly from research designed to support the business case for employers of various company sizes and industry types. PMID:24284747

  20. Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects.

    Science.gov (United States)

    Balan, Shabeesh; Iwayama, Yoshimi; Maekawa, Motoko; Toyota, Tomoko; Ohnishi, Tetsuo; Toyoshima, Manabu; Shimamoto, Chie; Esaki, Kayoko; Yamada, Kazuo; Iwata, Yasuhide; Suzuki, Katsuaki; Ide, Masayuki; Ota, Motonori; Fukuchi, Satoshi; Tsujii, Masatsugu; Mori, Norio; Shinkai, Yoichi; Yoshikawa, Takeo

    2014-01-01

    Histone H3 methylation at lysine 9 (H3K9) is a conserved epigenetic signal, mediating heterochromatin formation by trimethylation, and transcriptional silencing by dimethylation. Defective GLP (Ehmt1) and G9a (Ehmt2) histone lysine methyltransferases, involved in mono and dimethylation of H3K9, confer autistic phenotypes and behavioral abnormalities in animal models. Moreover, EHMT1 loss of function results in Kleefstra syndrome, characterized by severe intellectual disability, developmental delays and psychiatric disorders. We examined the possible role of histone methyltransferases in the etiology of autism spectrum disorders (ASD) and suggest that rare functional variants in these genes that regulate H3K9 methylation may be associated with ASD. Since G9a-GLP-Wiz forms a heteromeric methyltransferase complex, all the protein-coding regions and exon/intron boundaries of EHMT1, EHMT2 and WIZ were sequenced in Japanese ASD subjects. The detected variants were prioritized based on novelty and functionality. The expression levels of these genes were tested in blood cells and postmortem brain samples from ASD and control subjects. Expression of EHMT1 and EHMT2 isoforms were determined by digital PCR. We identified six nonsynonymous variants: three in EHMT1, two in EHMT2 and one in WIZ. Two variants, the EHMT1 ankyrin repeat domain (Lys968Arg) and EHMT2 SET domain (Thr961Ile) variants were present exclusively in cases, but showed no statistically significant association with ASD. The EHMT2 transcript expression was significantly elevated in the peripheral blood cells of ASD when compared with control samples; but not for EHMT1 and WIZ. Gene expression levels of EHMT1, EHMT2 and WIZ in Brodmann area (BA) 9, BA21, BA40 and the dorsal raphe nucleus (DoRN) regions from postmortem brain samples showed no significant changes between ASD and control subjects. Nor did expression levels of EHMT1 and EHMT2 isoforms in the prefrontal cortex differ significantly between ASD and

  1. Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation.

    Science.gov (United States)

    Li, Qing-Lan; Lei, Pin-Ji; Zhao, Quan-Yi; Li, Lianyun; Wei, Gang; Wu, Min

    2017-08-01

    Epigenetic marks are critical regulators of chromatin and gene activity. Their roles in normal physiology and disease states, including cancer development, still remain elusive. Herein, the epigenomic change of H3K9me3, as well as its potential impacts on gene activity and genome stability, was investigated in an in vitro breast cancer transformation model. The global H3K9me3 level was studied with western blotting. The distribution of H3K9me3 on chromatin and gene expression was studied with ChIP-Seq and RNA-Seq, respectively. The global H3K9me3 level decreases during transformation and its distribution on chromatin is reprogrammed. By combining with TCGA data, we identified 67 candidate oncogenes, among which five genes are totally novel. Our analysis further links H3K9me3 with transposon activity, and suggests H3K9me3 reduction increases the cell's sensitivity to DNA damage reagents. H3K9me3 reduction is possibly related with breast cancer transformation by regulating gene expression and chromatin stability during transformation.

  2. HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.

    Science.gov (United States)

    Večeřa, Josef; Bártová, Eva; Krejčí, Jana; Legartová, Soňa; Komůrková, Denisa; Rudá-Kučerová, Jana; Štark, Tibor; Dražanová, Eva; Kašpárek, Tomáš; Šulcová, Alexandra; Dekker, Frank J; Szymanski, Wiktor; Seiser, Christian; Weitzer, Georg; Mechoulam, Raphael; Micale, Vincenzo; Kozubek, Stanislav

    2018-01-01

    Although histone acetylation is one of the most widely studied epigenetic modifications, there is still a lack of information regarding how the acetylome is regulated during brain development and pathophysiological processes. We demonstrate that the embryonic brain (E15) is characterized by an increase in H3K9 acetylation as well as decreases in the levels of HDAC1 and HDAC3. Moreover, experimental induction of H3K9 hyperacetylation led to the overexpression of NCAM in the embryonic cortex and depletion of Sox2 in the subventricular ependyma, which mimicked the differentiation processes. Inducing differentiation in HDAC1-deficient mouse ESCs resulted in early H3K9 deacetylation, Sox2 downregulation, and enhanced astrogliogenesis, whereas neuro-differentiation was almost suppressed. Neuro-differentiation of (wt) ESCs was characterized by H3K9 hyperacetylation that was associated with HDAC1 and HDAC3 depletion. Conversely, the hippocampi of schizophrenia-like animals showed H3K9 deacetylation that was regulated by an increase in both HDAC1 and HDAC3. The hippocampi of schizophrenia-like brains that were treated with the cannabinoid receptor-1 inverse antagonist AM251 expressed H3K9ac at the level observed in normal brains. Together, the results indicate that co-regulation of H3K9ac by HDAC1 and HDAC3 is important to both embryonic brain development and neuro-differentiation as well as the pathophysiology of a schizophrenia-like phenotype. © 2017 Wiley Periodicals, Inc.

  3. Overview of Evaluation Methods for R&D Programs. A Directory of Evaluation Methods Relevant to Technology Development Programs

    Energy Technology Data Exchange (ETDEWEB)

    Ruegg, Rosalie [TIA Consulting, Inc., Emeral Isle, NC (United States); Jordan, Gretchen B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2007-03-01

    This document provides guidance for evaluators who conduct impact assessments to determine the “realized” economic benefits and costs, energy, environmental benefits, and other impacts of the Office of Energy Efficiency and Renewable Energy’s (EERE) R&D programs. The focus of this Guide is on realized outcomes or impacts of R&D programs actually experienced by American citizens, industry, and others.

  4. NRC review of passive reactor design certification testing programs: Overview, progress, and regulatory perspective

    Energy Technology Data Exchange (ETDEWEB)

    Levin, A.E.

    1995-09-01

    New reactor designs, employing passive safety systems, are currently under development by reactor vendors for certification under the U.S. Nuclear Regulatory Commission`s (NRC`s) design certification rule. The vendors have established testing programs to support the certification of the passive designs, to meet regulatory requirements for demonstration of passive safety system performance. The NRC has, therefore, developed a process for the review of the vendors` testing programs and for incorporation of the results of those reviews into the safety evaluations for the passive plants. This paper discusses progress in the test program reviews, and also addresses unique regulatory aspects of those reviews.

  5. Overview of experimental results obtained under the Prestressed Concrete Nuclear Pressure Vessel Development Program at the Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Naus, D.J.

    1978-01-01

    Under the Prestressed Concrete Nuclear Pressure Vessel Development Program at the Oak Ridge National Laboratory, various aspects of Prestressed Concrete Pressure Vessels (PCPVs) are investigated and evaluated with respect to reliability, structural performance, constructability, and economy. Based upon identified needs, analytical and experimental investigations are conducted. Areas of interest include finite-element analysis development, materials and structural behavior tests, instrumentation evaluation and development, and structural model tests. Studies have been recently completed in the following areas: concrete embedment instrumentation systems for PCPVs, grouted-nongrouted prestressing systems, acoustic emission as a technique for structural integrity monitoring, and model tests of steam-generator cavity closure plugs for a Gas-Cooled Fast Reactor (GCFR). An overview of results is presented

  6. CO2 Injectivity in Geological Storages: an Overview of Program and Results of the GeoCarbone-Injectivity Project

    International Nuclear Information System (INIS)

    Lombard, J.M.; Egermann, P.; Azaroual, M.; Pironon, J.; Broseta, D.; Egermann, P.; Munier, G.; Mouronval, G.

    2010-01-01

    The objective of the GeoCarbone-Injectivity project was to develop a methodology to study the complex phenomena involved in the near well bore region during CO 2 injection. This paper presents an overview of the program and results of the project, and some further necessary developments. The proposed methodology is based on experiments and simulations at the core scale, in order to understand (physical modelling and definition of constitutive laws) and quantify (calibration of simulation tools) the mechanisms involved in injectivity variations: fluid/rock interactions, transport mechanisms, geomechanical effects. These mechanisms and the associated parameters have then to be integrated in the models at the well bore scale. The methodology has been applied for the study of a potential injection of CO 2 in the Dogger geological formation of the Paris Basin, in collaboration with the other ANR GeoCarbone projects. (authors)

  7. An Overview of the NASA Aviation Safety Program (AVSP) Systemwide Accident Prevention (SWAP) Human Performance Modeling (HPM) Element

    Science.gov (United States)

    Foyle, David C.; Goodman, Allen; Hooley, Becky L.

    2003-01-01

    An overview is provided of the Human Performance Modeling (HPM) element within the NASA Aviation Safety Program (AvSP). Two separate model development tracks for performance modeling of real-world aviation environments are described: the first focuses on the advancement of cognitive modeling tools for system design, while the second centers on a prescriptive engineering model of activity tracking for error detection and analysis. A progressive implementation strategy for both tracks is discussed in which increasingly more complex, safety-relevant applications are undertaken to extend the state-of-the-art, as well as to reveal potential human-system vulnerabilities in the aviation domain. Of particular interest is the ability to predict the precursors to error and to assess potential mitigation strategies associated with the operational use of future flight deck technologies.

  8. Overview of the TCV tokamak program: scientific progress and facility upgrades

    DEFF Research Database (Denmark)

    Coda, S.; Ahn, J.; Albanese, R.

    2017-01-01

    The TCV tokamak is augmenting its unique historical capabilities (strong shaping, strong electron heating) with ion heating, additional electron heating compatible with high densities, and variable divertor geometry, in a multifaceted upgrade program designed to broaden its operational range with...

  9. Overview of the TCV tokamak program : scientific progress and facility upgrades

    NARCIS (Netherlands)

    Coda, S.; Ahn, J.; Albanese, R.; Alberti, S.; Alessi, E.; Allan, S.; Anand, H.; Anastassiou, G.; Andrèbe, Y.; Angioni, C.; Ariola, M.; Bernert, M.; Beurskens, M.N.A.; Bin, W.; Blanchard, P.; Blanken, T.C.; Boedo, J.A.; Bolzonella, T.; Bouquey, F.; Braunmüller, F.H.; Bufferand, H.; Buratti, P.; Calabró, G.; Camenen, Y.; Carnevale, D.; Carpanese, F.; Causa, F.; Cesario, R.; Chapman, I.T.; Chellai, O.; Choi, D.; Cianfarani, C.; Ciraolo, G.; Citrin, J.; Costea, S.; Crisanti, F.; Cruz, N.; Czarnecka, A.; Decker, J.; De Masi, G.; De Tommasi, G.; Douai, D.; Dunne, M.; Duval, B.P.; Eich, T.; Elmore, S.; Esposito, B.; Faitsch, M.; Fasoli, A.; Fedorczak, N.; Felici, F.; Février, O.; Ficker, O.; Fietz, S.; Fontana, M.; Frassinetti, L.; Furno, I.; Galeani, S.; Gallo, A.; Galperti, C.; Garavaglia, S.; Garrido, I.; Geiger, B.; Giovannozzi, E.; Gobbin, M.; Goodman, T.P.; Gorini, G.; Gospodarczyk, M.; Granucci, G.; Graves, J.P.; Guirlet, R.; Hakola, A.; Ham, C.; Harrison, J.; Hawke, J.; Hennequin, P.; Hnat, B.; Hogeweij, D.; Hogge, J.- P.; Honoré, C.; Hopf, C.; Horáček, J.; Huang, Z.; Igochine, V.; Innocente, P.; Ionita-Schrittwieser, C.; Isliker, H.; Jacquier, R.; Jardin, A.; Kamleitner, J.; Karpushov, A.; Keeling, D.L.; Kirneva, N.; Kong, M.; Koubiti, M.; Kovacic, J.; Krämer-Flecken, A.; Krawczyk, N.; Kudlacek, O.; Labit, B.; Lazzaro, E.; Le, H.B.; Lipschultz, B.; Llobet, X.; Lomanowski, B.; Loschiavo, V.P.; Lunt, T.; Maget, P.; Maljaars, E.; Malygin, A.; Maraschek, M.; Marini, C.; Martin, P.; Martin, Y.; Mastrostefano, S.; Maurizio, R.; Mavridis, M.; Mazon, D.; McAdams, R.; McDermott, R.; Merle, A.; Meyer, H.; Militello, F.; Miron, I.G.; Molina Cabrera, P.A.; Moret, J.M.; Moro, A.; Moulton, D.; Naulin, V.; Nespoli, F.; Nielsen, A.H.; Nocente, M.; Nouailletas, R.; Nowak, S.; Odstrčil, T.; Papp, G.; Papřok, R.; Pau, A.; Pautasso, G.; Pericoli Ridolfini, V.; Piovesan, P.; Piron, C.; Pisokas, T.; Porte, L.; Preynas, M.; Ramogida, G.; Rapson, C.; Rasmussen, J.J.; Reich, M.; Reimerdes, H.; Reux, C.; Ricci, P.; Rittich, D.; Riva, F.; Robinson, T.; Saarelma, S.; Saint-Laurent, F.; Sauter, O.; Scannell, R.; Schlatter, Ch.; Schneider, B.; Schneider, P.; Schrittwieser, R.; Sciortino, F.; Sertoli, M.; Sheikh, U.; Sieglin, B.; Silva, M.; Sinha, J.; Sozzi, C.; Spolaore, M.; Stange, T.; Stoltzfus-Dueck, T.; Tamain, P.; Teplukhina, A.; Testa, D.; Theiler, C.; Thornton, A.; Tophøj, L.; Tran, M.Q.; Tsironis, C.; Tsui, C.; Uccello, A.; Vartanian, S.; Verdoolaege, G.; Verhaegh, K.H.A.; Vermare, L.; Vianello, N.; Vijvers, W.A.J.; Vlahos, L.; Vu, N.M.T.; Walkden, N.; Wauters, T.; Weisen, H.; Wischmeier, M.; Zestanakis, P.; Zuin, M.

    2017-01-01

    The TCV tokamak is augmenting its unique historical capabilities (strong shaping, strong electron heating) with ion heating, additional electron heating compatible with high densities, and variable divertor geometry, in a multifaceted upgrade program designed to broaden its operational range without

  10. An overview of the Indian program related to fast reactor core mechanical behaviour

    International Nuclear Information System (INIS)

    Govindarajan, S.; Bhoje, S.B.; Paranjpe, S.R.

    1984-01-01

    This Indian review paper presents the evolution of the fast breeder program which began with fast breeder test reactor (FBTR) commencing in 1972. The state-of-art in the field of core mechanical behaviour is reviewed

  11. Substance Abuse among the Deaf Population: An Overview of Current Strategies, Programs and Barriers to Recovery.

    Science.gov (United States)

    Lane, Katherine E.

    1989-01-01

    The paper analyzes the problem of alcohol and drug abuse among the deaf population focusing on: precipitating factors leading to substance abuse; barriers to recovery; and descriptions of several treatment centers, programs, and services. (JDD)

  12. Combating Political Police: An Overview of National Action’s Counterintelligence Program, 1982–1990

    Directory of Open Access Journals (Sweden)

    Troy Whitford

    2013-06-01

    Full Text Available During the mid to late 1980s the radical nationalist group National Action was targeted by domestic intelligence agencies. Known as “Operation Odessa” it was part of Australian Security Intelligence Organisation’s (ASIO program to combat what it saw as a rise in politically motivated violence. ASIO and state police Special Branch officers placed the group under surveillance and sent agents to disrupt meetings and recruit informants. Concurrently, National Action had developed its own counterintelligence program structuring the group in an effort to preserve secrecy, educating its membership in situational awareness and designating a senior member as an intelligence officer. Ultimately National Action counterintelligence program was unable to match the highly resourced government agencies and internal discipline issues meant the group was eventually disbanded. However, National Action’s effort to develop a counterintelligence program provides some examples of what low resourced Issue Motivated Groups are capable of achieving.

  13. The Idaho Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program overview

    International Nuclear Information System (INIS)

    Dorn, R.V. III; Griebenow, M.L.; Ackermann, A.L.; Miller, L.G.; Miller, D.L.; Wheeler, F.J.; Bradshaw, K.M.; Wessol, D.E.; Harker, Y.D.; Nigg, D.W.; Randolph, P.D.; Bauer, W.F.; Gavin, P.R.; Richards, T.L.

    1992-01-01

    The Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program has been funded since 1988 to evaluate brain tumor treatment using Na 2 B 12 H 11 SH (borocaptate sodium or BSH) and epithermal neutrons. The PBF/BNCT Program pursues this goal as a comprehensive, multidisciplinary, multiorganizational endeavor applying modern program management techniques. The initial focus was to: (1) establish a representative large animal model and (2) develop the generic analytical and measurement capabilities require to control treatment repeatability and determine critical treatment parameters independent of tumor type and body location. This paper will identify the PBF/BNCT Program elements and summarize the status of some of the developed capabilities

  14. Foreign Aid: An Introductory Overview of U.S. Programs and Policy

    Science.gov (United States)

    2004-04-15

    microcredit institutions. Training. Transfer of know-how is a significant part of most assistance programs. The International Military and...their varied developmental purposes. For instance, grants are sometimes provided to microcredit organizations which in turn provide loans to

  15. 2017-04-28_W88 ALT 370 Program Overview(OUO).

    Energy Technology Data Exchange (ETDEWEB)

    Daniels, Vonceil

    2017-04-01

    All major program milestones have been met and the program is executing within budget. The ALT 370 program achieved Phase 6.4 authorization in February of this year. Five component Final Design Reviews (FDRs) have been completed, indicating progress in finalizing the design and development phase of the program. A series of ground-based qualification activities have demonstrated that designs are meeting functional requirements. The first fully functional flight test, FCET-53, demonstrated end-to-end performance in normal flight environments in February. Similarly, groundbased nuclear safety and hostile environments testing indicates that the design meets requirements in these stringent environments. The first in a series of hostile blast tests was successfully conducted in April.

  16. An Overview of the Society of Actuaries and Its Education Programs

    Science.gov (United States)

    Klugman, Stuart; Long, Gena

    2014-01-01

    The Society of Actuaries (SOA) is the world's largest actuarial organization. This article describes the SOA with particular attention paid to its education and qualification processes and resources available for university and college programs.

  17. 75 FR 6007 - Office of Innovation and Improvement; Overview Information; School Leadership Grant Program...

    Science.gov (United States)

    2010-02-05

    ... 60 months. III. Eligibility Information 1. Eligible Applicants: High-need LEAs; consortia of high... School Libraries program, these same data apply to the ESEA definition of a high-need LEA used for...

  18. Overview of the biomedical and environmental programs at the Oak Ridge National Laboratory. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Pfuderer, H.A.; Moody, J.B. (comps.)

    1981-07-01

    Separate abstracts were prepared for each of the 6 chapters presented by the six divisions involved in the Biomedical and Environmental Sciences Program at Oak Ridge National Laboratory. The introduction is not covered by an abstract and deals with the environmental, health and safety considerations of energy technology decisions, the major initiatives now being taken by these 6 divisions, and recent major accomplishments in the biomedical and environmental science program. (KRM)

  19. Overview of the biomedical and environmental programs at the Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Pfuderer, H.A.; Moody, J.B.

    1981-07-01

    Separate abstracts were prepared for each of the 6 chapters presented by the six divisions involved in the Biomedical and Environmental Sciences Program at Oak Ridge National Laboratory. The introduction is not covered by an abstract and deals with the environmental, health and safety considerations of energy technology decisions, the major initiatives now being taken by these 6 divisions, and recent major accomplishments in the biomedical and environmental science program

  20. Overview of current programs and trends in assessment of health effects

    International Nuclear Information System (INIS)

    Thiessen, J.W.

    1983-01-01

    Radiation research programs of the US DOE are discussed in the presentation. Data bases have been established from epidemiological studies on radiation exposures and effects in atom bomb survivors, nuclear facility personnel, radium dial painters and populations living downwind from above- and below-ground nuclear tests. In addition, a Risk Analysis Program has been established to evaluate energy technologies and related problems with respect to their health and environmental uncertainties. 8 figures

  1. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation

    Energy Technology Data Exchange (ETDEWEB)

    Alamdar, Ambreen; Xi, Guochen [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Huang, Qingyu, E-mail: qyhuang@iue.ac.cn [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Centre for Epigenetics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M (Denmark); Tian, Meiping [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Eqani, Syed Ali Musstjab Akber Shah [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information & Technology, Islamabad (Pakistan); Shen, Heqing, E-mail: hqshen@iue.ac.cn [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China)

    2017-07-01

    Arsenic exposure has been associated with male reproductive dysfunction by disrupting steroidogenesis; however, the roles of epigenetic drivers, especially histone methylation in arsenic-induced steroidogenic toxicity remain not well documented. In this study, we investigated the role of histone H3 lysine 9 (H3K9) methylation in steroidogenesis disturbance in mouse Leydig cells (MLTC-1) due to arsenic exposure. Our results indicated that mRNA and protein expression levels of 3β-hydroxysteroid dehydrogenase (3β-HSD) were both significantly up-regulated while the rest of key genes involved in steroidogenesis were down-regulated. Moreover, arsenic exposure significantly decreased the histone H3K9 di- and tri-methylation (H3K9me2/3) levels in MLTC-1 cells. Since H3K9 demethylation leads to gene activation, we further investigated whether the induction of 3β-HSD expression was ascribed to reduced H3K9 methylation. The results showed that H3K9me2/3 demethylase (JMJD2A) inhibitor, quercetin (Que) significantly attenuated the decrease of H3K9me2/3 and increase of 3β-HSD expression induced by arsenic. To further elucidate the mechanism for the activation of 3β-HSD, we determined the histone H3K9 methylation levels in Hsd3b gene promoter, which also showed significant decrease of H3K9me2/3 in the investigated region after arsenic exposure. Considering these results, we conclude that arsenic exposure induced 3β-HSD up-regulation by suppressing H3K9me2/3 status, which is suggested as a compensatory mechanism for steroidogenic disturbance in MLTC-1 cells. - Highlights: • Epigenetic mechanisms of arsenic-induced male reproductive toxicity remain unclear. • Arsenic disturbs the expression of key steroidogenic genes in MLTC-1 cells. • Histone H3K9 di- and tri-methylation was suppressed in arsenic-exposed cells. • Arsenic activates 3β-HSD expression through repression of histone H3K9 methylation.

  2. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation

    International Nuclear Information System (INIS)

    Alamdar, Ambreen; Xi, Guochen; Huang, Qingyu; Tian, Meiping; Eqani, Syed Ali Musstjab Akber Shah; Shen, Heqing

    2017-01-01

    Arsenic exposure has been associated with male reproductive dysfunction by disrupting steroidogenesis; however, the roles of epigenetic drivers, especially histone methylation in arsenic-induced steroidogenic toxicity remain not well documented. In this study, we investigated the role of histone H3 lysine 9 (H3K9) methylation in steroidogenesis disturbance in mouse Leydig cells (MLTC-1) due to arsenic exposure. Our results indicated that mRNA and protein expression levels of 3β-hydroxysteroid dehydrogenase (3β-HSD) were both significantly up-regulated while the rest of key genes involved in steroidogenesis were down-regulated. Moreover, arsenic exposure significantly decreased the histone H3K9 di- and tri-methylation (H3K9me2/3) levels in MLTC-1 cells. Since H3K9 demethylation leads to gene activation, we further investigated whether the induction of 3β-HSD expression was ascribed to reduced H3K9 methylation. The results showed that H3K9me2/3 demethylase (JMJD2A) inhibitor, quercetin (Que) significantly attenuated the decrease of H3K9me2/3 and increase of 3β-HSD expression induced by arsenic. To further elucidate the mechanism for the activation of 3β-HSD, we determined the histone H3K9 methylation levels in Hsd3b gene promoter, which also showed significant decrease of H3K9me2/3 in the investigated region after arsenic exposure. Considering these results, we conclude that arsenic exposure induced 3β-HSD up-regulation by suppressing H3K9me2/3 status, which is suggested as a compensatory mechanism for steroidogenic disturbance in MLTC-1 cells. - Highlights: • Epigenetic mechanisms of arsenic-induced male reproductive toxicity remain unclear. • Arsenic disturbs the expression of key steroidogenic genes in MLTC-1 cells. • Histone H3K9 di- and tri-methylation was suppressed in arsenic-exposed cells. • Arsenic activates 3β-HSD expression through repression of histone H3K9 methylation.

  3. The US/USSR Biological Satellite Program: COSMOS 936 Mission Overview

    Science.gov (United States)

    Souza, K. A.

    1978-01-01

    On August 3, 1977, the Soviet Union launched Cosmos 936, an unmanned spacecraft carrying biology and physics experiments from 9 countries, including both the Soviet Union and U.S. The launch marked the second time the Soviet Union has flown U.S. experiments aboard one of its spacecraft, the first being Cosmos 782 launched Nov. 25, 1975, which remained in orbit 19.5 days. Aboard Cosmos 936 were: 30 young male Wistar SPF rats, 20 of which was exposed to hypogravity during flight while the remainder were subjected to a l x g acceleration by continuous configuration; 2) experiments with plants and fruit flies; 3) radiation physics experiments; and 4) a heat convection experiment. After 18.5 days in orbit, the spacecraft landed in central Asia where a Soviet recovery team began experiment operations, including animal autopsies, within 4.5 hr of landing. Half of the animals were autopsied at the recovery site and the remainder returned to Moscow and allowed to readapt to terrestrial gravity for 25 days after which they, too, were autopsied. Specimens for U.S. were initially prepared at the recovery site or Soviet laboratories and transferred to U.S. laboratories for complete analyses. An overview of the mission focusing on preflight, on-orbit, and postflight activities pertinent to the seven U.S. experiments aboard Cosmos 936 will be presented.

  4. The Medicare Health Outcomes Survey program: Overview, context, and near-term prospects

    Directory of Open Access Journals (Sweden)

    Miller Nancy A

    2004-07-01

    Full Text Available Abstract In 1996, the Centers for Medicare & Medicaid Services (CMS initiated the development of the Medicare Health Outcomes Survey (HOS. It is the first national survey to measure the quality of life and functional health status of Medicare beneficiaries enrolled in managed care. The program seeks to gather valid and reliable health status data in Medicare managed care for use in quality improvement activities, public reporting, plan accountability and improving health outcomes based on competition. The context that led to the development of the HOS was formed by the convergence of the following factors: 1 a recognized need to monitor the performance of managed care plans, 2 technical expertise and advancement in the areas of quality measurement and health outcomes assessment, 3 the existence of a tested functional health status assessment tool (SF-36®1, which was valid for an elderly population, 4 CMS leadership, and 5 political interest in quality improvement. Since 1998, there have been six baseline surveys and four follow up surveys. CMS, working with its partners, performs the following tasks as part of the HOS program: 1 Supports the technical/scientific development of the HOS measure, 2 Certifies survey vendors, 3 Collects Health Plan Employer Data and Information Set(HEDIS®2 HOS data, 4 Cleans, scores, and disseminates annual rounds of HOS data, public use files and reports to CMS, Quality Improvement Organizations (QIOs, Medicare+Choice Organizations (M+COs, and other stakeholders, 5 Trains M+COs and QIOs in the use of functional status measures and best practices for improving care, 6 Provides technical assistance to CMS, QIOs, M+COs and other data users, and 7 Conducts analyses using HOS data to support CMS and HHS priorities. CMS has recently sponsored an evaluation of the HOS program, which will provide the information necessary to enhance the future administration of the program. Information collected to date reveals that the

  5. International cooperation program on non-destructive inspection. Overview of PINC and PARENT

    International Nuclear Information System (INIS)

    Komura, Ichiro

    2016-01-01

    PINC (The Program for the Inspection of Nickel Alloy Components) and its successor program PARENT (The Program to Assess the Reliability of Emerging Nondestructive Techniques) are the programs on the verification of nondestructive inspection technology for detecting / dimension-evaluating the stress corrosion cracking (SCC) generated in the weld zone of nickel-based alloy. The US Nuclear Regulatory Commission plays a leading role, and the institutions of the United States, Japan, Korea, Sweden, Finland, and Switzerland participate in them. PINC was run from 2003 to 2009, and PARENT is currently underway with a schedule from 2010 to July 2017, including the extension period after July 2015. This paper outlined the implementation items and test results / achievements of PINC and PARENT programs. The target parts of PINC were a safe-end reducer and a reactor bottom instrument tube rest, and the flaw detection test and its analytical evaluation were carried out with a focus on the detectability and the sizing accuracy of defects. As a feature of the verification test of the non-destructive inspection technology in PARENT, two kinds of flaw detection tests, namely blind test and open test, are distinctively carried out. (A.O.)

  6. Overview of the Robert Wood Johnson Foundation Nurse Faculty Scholars program.

    Science.gov (United States)

    Campbell, Jacquelyn; Ladden, Maryjoan D; McBride, Angela Barron; Cimino, Andrea; Kostas-Polston, Elizabeth; Deming, Katie

    The Robert Wood Johnson Foundation Nurse Faculty Scholars program was created to address the nursing faculty shortage and thereby decrease the nursing shortage. The purpose of the study was to describe the program development, implementation, and ongoing outcome evaluation. Data on scholarly productivity, impact of research, research funding, and leadership positions were compiled, including an h-index (impact of publications) comparison with a comparison group of other interdisciplinary faculty at the same institutions of the 90 current and alumni scholars. There is evidence of the achievements of the individual scholars; however, the effect of the synergy of the multiple components of the program is difficult to capture in traditional evaluation strategies. The sense of possibility and responsibility (to the profession, to improving the health of all Americans, and to one's school of nursing and university) was a significant outcome of the program. Lessons learned from the program are important for the leadership development and retention of nursing faculty. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. An overview of the history of the US geologic repository program: policies, polities, and the public

    International Nuclear Information System (INIS)

    Hongnian Jow

    2010-01-01

    The high-level radioactive waste (HLW) and spent nuclear fuels (SNF) disposal program in the US started in 1950s soon after the Atomic Energy Act was passed by the US Congress. Early on, in 1955, the nuclear experts had recognized the difficulty of waste disposal as the most difficult problem in the peaceful use of nuclear energy. The development and evolution of the HLW/SNF disposal program from 1950s to the current status will be briefly discussed, including the importance of legislation process of Nuclear Waste Policy Act, its Amendments, and their impacts on the development of disposal program in the US. The recent developments of Yucca Mountain project from License Application in 2008 through the DOE's announcement of withdrawing the License Application in January 2010 will also be discussed. (authors)

  8. An overview of the U.S. programs on properties of primary circuit materials

    International Nuclear Information System (INIS)

    Brinkman, C.R.; Sikka, V.K.; Booker, M.K.

    1977-01-01

    The objective of U.S. Breeder Reactor Programs associated with primary circuit structural materials is to develop the design data base and associated design technology on existing commercially available materials as well as new alloys. This will permit economic operation of components at acceptable levels of plant availability and at up to 40-yr lifetimes for inaccessible components. Long-term component reliability, elevated-temperature service within the creep range, and resistance to sodium attack and irradiation damage, along with design in compliance with ASME Codes and RDT Specifications, have required that the U.S. Programs be directed toward contributing knowledge in a number of areas. These areas, relating to material deformation, failure modes, compatibility, fabrication, long-term behavior, irradiation damage, and availability will be discussed. The U.S. Structural Material Programs concerned with primary-circuit components will be reviewed, and their current and future contributions to knowledge of these areas will be explained. (author)

  9. Overview of the U.S. programs on properties of primary circuit materials

    International Nuclear Information System (INIS)

    Brinkman, C.R.; Sikka, V.K.; Booker, M.K.

    1977-01-01

    The objective of U.S. Breeder Reactor Programs associated with primary circuit structural materials is to develop the design data base and associated design technology on existing commercially available materials as well as new alloys. This will permit economic operation of components at acceptable levels of plant availability and at up to 40-year lifetimes for inaccessible components. Long-term component reliability, elevated-temperature service within the creep range, and resistance to sodium attack and irradiation damage, along with design in compliance with ASME Codes and RDT Specifications, have required that the U.S. programs be directed toward contributing knowledge in a number of areas. These areas, relating to material deformation, failure modes, compatibility, fabrication, long-term behavior, irradiation damage, and availability will be discussed. The U.S. Structural Material Programs concerned with primary-circuit components will be reviewed, and their current and future contributions to knowledge of these areas will be explained

  10. An overview of the U.S. programs on properties of primary circuit materials

    Energy Technology Data Exchange (ETDEWEB)

    Brinkman, C R; Sikka, V K; Booker, M K [Metals and Ceramics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1977-07-01

    The objective of U.S. Breeder Reactor Programs associated with primary circuit structural materials is to develop the design data base and associated design technology on existing commercially available materials as well as new alloys. This will permit economic operation of components at acceptable levels of plant availability and at up to 40-yr lifetimes for inaccessible components. Long-term component reliability, elevated-temperature service within the creep range, and resistance to sodium attack and irradiation damage, along with design in compliance with ASME Codes and RDT Specifications, have required that the U.S. Programs be directed toward contributing knowledge in a number of areas. These areas, relating to material deformation, failure modes, compatibility, fabrication, long-term behavior, irradiation damage, and availability will be discussed. The U.S. Structural Material Programs concerned with primary-circuit components will be reviewed, and their current and future contributions to knowledge of these areas will be explained. (author)

  11. HYSOLAR an overview on the German-Saudi Arabian program on solar hydrogen

    International Nuclear Information System (INIS)

    Steeb, H.; Seeger, W.

    1993-01-01

    The first phase of HYSOLAR, which ended in 1991, was focusing mainly on investigation, test and improvement of hydrogen production technologies. This paper shortly reviews the most important results: a 2 kW test and research facility in Jeddah; fundamental research in the fields of photo-electrochemistry, advanced alkaline electrolysis and alkaline fuel cells; system studies and decentralized hydrogen utilization; program for education. An outlook into the second phase program, where more emphasis is laid on hydrogen utilization technologies, is also included. 1 tab., 93 refs

  12. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation

    DEFF Research Database (Denmark)

    Alamdar, Ambreen; Xi, Guochen; Huang, Qingyu

    2017-01-01

    methylation. The results showed that H3K9me2/3 demethylase (JMJD2A) inhibitor, quercetin (Que) significantly attenuated the decrease of H3K9me2/3 and increase of 3β-HSD expression induced by arsenic. To further elucidate the mechanism for the activation of 3β-HSD, we determined the histone H3K9 methylation......Arsenic exposure has been associated with male reproductive dysfunction by disrupting steroidogenesis; however, the roles of epigenetic drivers, especially histone methylation in arsenic-induced steroidogenic toxicity remain not well documented. In this study, we investigated the role of histone H3...... lysine 9 (H3K9) methylation in steroidogenesis disturbance in mouse Leydig cells (MLTC-1) due to arsenic exposure. Our results indicated that mRNA and protein expression levels of 3β-hydroxysteroid dehydrogenase (3β-HSD) were both significantly up-regulated while the rest of key genes involved...

  13. 75 FR 10225 - Office of Postsecondary Education; Overview Information; Language Resource Centers Program...

    Science.gov (United States)

    2010-03-05

    ... this program in 34 CFR parts 655 and 669. II. Award Information Type of Award: Discretionary grants... in charts, tables, figures, and graphs. Use a font that is either 12 point or larger, or no smaller than 10 pitch (characters per inch). Use one of the following fonts: Times New Roman, Courier, Courier...

  14. Overview of the waste/barrier/rock interactions program of the basalt waste isolation project

    International Nuclear Information System (INIS)

    Salter, P.F.; Burnell, J.R.; Lane, D.L.

    1986-01-01

    The waste package waste/barrier/rock interactions testing program of the Basalt Waste Isolation Project is designed to assess the interactions between nuclear waste forms, other waste package components, and the environment in order to evaluate long-term waste package isolation (radionuclide release) behavior. The program involves reacting fully radioactive waste forms with combinations of steel or copper container material and basalt/bentonite packing material in site-specific ground water under anticipated repository conditions to obtain the steady state radionuclide concentrations required to predictively model waste package radionuclide concentrations required to predictively model waste package radionuclide releases. Both static and flow-through autoclaves are being used in the test program to determine radionuclide concentrations as a function of time and groundwater flow rate, and to evaluate the solid phase and water chemistry changes that control those concentrations. This test program, when combined with project hydrologic and geochemical testing and modeling efforts, and natural analog studies, provides the information required to evaluate long-term radionuclide mobility within a waste package emplaced in a basalt repository

  15. What We Know about Guided Pathways: Helping Students to Complete Programs Faster. Research Overview

    Science.gov (United States)

    Bailey, Thomas; Jaggars, Shanna Smith; Jenkins, Davis

    2015-01-01

    The idea behind guided pathways is straightforward. College students are more likely to complete a degree in a timely fashion if they choose a program and develop an academic plan early on, have a clear road map of the courses they need to take to complete a credential, and receive guidance and support to help them stay on plan. However, most…

  16. 76 FR 4330 - American Overseas Research Centers (AORC) Program; Office of Postsecondary Education; Overview...

    Science.gov (United States)

    2011-01-25

    ... to pay all or a portion of the cost of establishing or operating a center or program, including the... project, the Secretary considers-- (a) The quality and sufficiency of strategies for ensuring equal access... underrepresented based on race, color, national origin, gender, age, or disability. (b) The extent to which the...

  17. 75 FR 13735 - Office of Innovation and Improvement; Overview Information; Charter Schools Program (CSP): State...

    Science.gov (United States)

    2010-03-23

    ... financial assistance for the planning, program design, and initial implementation of charter schools, and to... process for the denial of an application for a charter school. Priority 4--High Degree of Autonomy (10 points). The State ensures that each charter school has a high degree of autonomy over the charter school...

  18. 75 FR 43510 - Office of Innovation and Improvement; Overview Information; Charter Schools Program (CSP) Grants...

    Science.gov (United States)

    2010-07-26

    ... providing financial assistance for the planning, program design, and initial implementation of charter... schools. The Secretary also encourages the applicant to include a description of the degree of autonomy... performance report, including financial information, as directed by the Secretary. If you receive a multi-year...

  19. Special Education Program Evaluation: A Planning Guide. An Overview. CASE Commissioned Series.

    Science.gov (United States)

    McLaughlin, John A.

    This resource guide is intended to help in planning special education program evaluations. It focuses on: basic evaluation concepts, identification of special education decision makers and their information needs, specific evaluation questions, procedures for gathering relevant information, and evaluation of the evaluation process itself.…

  20. OVERVIEW OF ADVANCED PETROLEUM-BASED FUELS-DIESEL EMISSIONS CONTROL PROGRAM (APBF-DEC)

    Energy Technology Data Exchange (ETDEWEB)

    Sverdrup, George M.

    2000-08-20

    The Advanced Petroleum-Based Fuels-Diesel Emissions Control Program (APBF-DEC) began in February 2000 and is supported by government agencies and industry. The purpose of the APBF-DEC program is to identify and evaluate the optimal combinations of fuels, lubricants, diesel engines, and emission control systems to meet the projected emission standards for the 2000 to 2010 time period. APBF-DEC is an outgrowth of the earlier Diesel Emission Control-Sulfur Effects Program (DECSE), whose objective is to determine the impact of the sulfur levels in fuel on emission control systems that could lower the emissions of NOx and particulate matter (PM) from diesel powered vehicles in the 2002 to 2004 period. Results from the DECSE studies of two emission control technologies-diesel particle filter (DPF) and NOx adsorber-will be used in the APBF-DEC program. These data are expected to provide initial information on emission control technology options and the effects of fuel properties (including additives) on the performance of emission control systems.

  1. Overview of Lidar Contributions to the Atmospheric Carbon and Transport - America (ACT-America) Program

    Science.gov (United States)

    Davis, K. J.; Meadows, B.; Barrick, J. D. W.; Bell, E.; Browell, E. V.; Campbell, J. F.; DiGangi, J. P.; Chen, G.; Dobler, J. T.; Fan, T. F.; Feng, S.; Fried, A.; Kooi, S. A.; Lauvaux, T.; Lin, B.; McGill, M. J.; Miles, N.; Nehrir, A. R.; Obland, M. D.; O'Dell, C.; Pal, S.; Pauly, R.; Sweeney, C.; Yang, M. Y.

    2017-12-01

    The Atmospheric Carbon and Transport - America (ACT-America) is an Earth Venture Suborbital -2 (EVS-2) mission sponsored by the Earth Science Division of NASA's Science Mission Directorate. A major objective is to enhance our knowledge of the sources/sinks and transport of atmospheric CO2 through the application of remote and in situ airborne measurements of CO2 and other atmospheric properties on spatial and temporal scales not previously available to the science community. ACT-America consists of five campaigns to measure regional carbon and evaluate transport under various meteorological conditions in three regional areas of the Continental United States. Three of the five campaigns, summer 2016, winter 2017, and fall 2017, have taken place. Data have been collected during these campaigns using 2 airborne platforms (NASA Wallops' C-130 and NASA Langley's B-200) with in-situ instruments on both aircraft and three lidar systems on the C-130, along with instrumented towers and coordinated under flights with the Orbiting Carbon Observatory (OCO-2) satellite. The lidar systems include the Harris Corp. Multi-Frequency Fiber Laser Lidar (MFLL), the NASA Langley ASCENDS CarbonHawk Experiment Simulator (ACES) and the Goddard Cloud Physics Laboratory (CPL). The airborne lidars provide unique data that complement the more traditional in situ sensors. Lidar CO2 measurements provide integrated views of spatial variations of partial columns of atmospheric CO2 which can be adjusted to the column of scientific interest by changing flight altitudes. Lidar backscatter data provide detailed views of atmospheric layers, including the atmospheric boundary layer, residual layers, and cloud layers. The combination of these two lidars provide a far more comprehensive view of atmospheric structure and CO2 content than can be achieved with in situ measurements alone. This presentation provides an overview of the application of these three lidar systems toward achieving ACT

  2. Overview about the fuel cell bus demonstration programs CUTE, ECTOS and STEP

    International Nuclear Information System (INIS)

    Faltenbacher, M.; Fischer, M.; Eyerer, P.; Binder, M.; Schuckert, M.

    2004-01-01

    'Full text:' The paper will give an overview about the CUTE, ECTOS and STEP projects. The aim of the projects is to develop and demonstrate a emission-free and low-noise transport system, including the accompanying energy infrastructure, which has great potential for reducing the global greenhouse effect according to the Kyoto protocol, improving the quality of the atmosphere and life in densely populated areas and conserving fossil resources. For this purpose the application of the innovative hydrogen-based fuel cell technology is established by using fuel cell powered buses in an urban environment together with novel hydrogen production and support systems as part of a European Union wide demonstration scheme. The project demonstrates also to European Society the availability of the FC technology as a safe and reliable transportation technology. The major objectives are as follows: Demonstration of more than 20 fuel cell powered regular service buses over a period of two years in several European inner city areas to illustrate the different operating conditions to be found in Europe; Design, construction and operation of the necessary infrastructure for hydrogen production, including the required refuelling stations; Collection of findings concerning the construction and operating behaviour of hydrogen production for mobile use, and exchange of experiences including bus operation under differing conditions among the numerous participating companies; and, the research work of IKP and PE comprises the ecological analysis of the entire life cycle and comparison with conventional alternatives (diesel driven buses, CNG-buses). It also includes the economical analysis of the hydrogen infrastructure. First experiences from CUTE and ECTOS were presented. (author)

  3. An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.

    Science.gov (United States)

    Sabbattini, Pierangela; Sjoberg, Marcela; Nikic, Svetlana; Frangini, Alberto; Holmqvist, Per-Henrik; Kunowska, Natalia; Carroll, Tom; Brookes, Emily; Arthur, Simon J; Pombo, Ana; Dillon, Niall

    2014-03-01

    Methylated histones H3K9 and H3K27 are canonical epigenetic silencing modifications in metazoan organisms, but the relationship between the two modifications has not been well characterized. H3K9me3 coexists with H3K27me3 in pluripotent and differentiated cells. However, we find that the functioning of H3K9me3 is altered by H3S10 phosphorylation in differentiated postmitotic osteoblasts and cycling B cells. Deposition of H3K9me3/S10ph at silent genes is partially mediated by the mitogen- and stress-activated kinases (MSK1/2) and the Aurora B kinase. Acquisition of H3K9me3/S10ph during differentiation correlates with loss of paused S5 phosphorylated RNA polymerase II, which is present on Polycomb-regulated genes in embryonic stem cells. Reduction of the levels of H3K9me3/S10ph by kinase inhibition results in increased binding of RNAPIIS5ph and the H3K27 methyltransferase Ezh1 at silent promoters. Our results provide evidence of a novel developmentally regulated methyl-phospho switch that modulates Polycomb regulation in differentiated cells and stabilizes repressed states.

  4. Alternative response technology program for the Deepwater Horizon in the Gulf of Mexico - an overview

    International Nuclear Information System (INIS)

    Cortez, Michael J.; Rowe, Hunter G.

    2011-01-01

    The innovative approach utilized by the Alternative Response Technology (ART) Program for the MC252 Deepwater Horizon response in the Gulf of Mexico during 2010 was presented in this paper. The ART program is authorized by the Unified Area Command. This paper focuses on the spill response technologies that were implemented offshore, near shore and on-shore, and covers technologies related to booming, skimming, separation, sand cleaning, surveillance and detection. A process was designed and implemented for capturing ideas real time, which leveraged the public's ingenuity and entrepreneurial spirit. About 120,000 individual ideas were submitted by the public globally from more than 100 countries. About 40,000 of these ideas were related to addressing the spill response. There are about 100 new technologies related to spill response that were formally evaluated and/or field tested, and approximately 25 of those tested were successfully implemented across the spill response area.

  5. Alternative response technology program for the Deepwater Horizon in the Gulf of Mexico - an overview

    Energy Technology Data Exchange (ETDEWEB)

    Cortez, Michael J.; Rowe, Hunter G. [BP - Gulf Coast Restoration (United States)], email: michael.cortez@bp.com

    2011-07-01

    The innovative approach utilized by the Alternative Response Technology (ART) Program for the MC252 Deepwater Horizon response in the Gulf of Mexico during 2010 was presented in this paper. The ART program is authorized by the Unified Area Command. This paper focuses on the spill response technologies that were implemented offshore, near shore and on-shore, and covers technologies related to booming, skimming, separation, sand cleaning, surveillance and detection. A process was designed and implemented for capturing ideas real time, which leveraged the public's ingenuity and entrepreneurial spirit. About 120,000 individual ideas were submitted by the public globally from more than 100 countries. About 40,000 of these ideas were related to addressing the spill response. There are about 100 new technologies related to spill response that were formally evaluated and/or field tested, and approximately 25 of those tested were successfully implemented across the spill response area.

  6. The DOE/NREL Next Generation Natural Gas Vehicle Program - An Overview

    International Nuclear Information System (INIS)

    Kevin Walkowicz; Denny Stephens; Kevin Stork

    2001-01-01

    This paper summarizes the Next Generation Natural Gas Vehicle (NG-NGV) Program that is led by the U.S. Department Of Energy's (DOE's) Office of Heavy Vehicle Technologies (OHVT) through the National Renewable Energy Laboratory (NREL). The goal of this program is to develop and implement one Class 3-6 compressed natural gas (CNG) prototype vehicle and one Class 7-8 liquefied natural gas (LNG) prototype vehicle in the 2004 to 2007 timeframe. OHVT intends for these vehicles to have 0.5 g/bhp-hr or lower emissions of oxides of nitrogen (NOx) by 2004 and 0.2 g/bhp-hr or lower NOx by 2007. These vehicles will also have particulate matter (PM) emissions of 0.01 g/bhp-hr or lower by 2004. In addition to ambitious emissions goals, these vehicles will target life-cycle economics that are compatible with their conventionally fueled counterparts

  7. Overview of the LBL/LLNL negative-ion-based neutral beam program

    International Nuclear Information System (INIS)

    Pyle, R.V.

    1980-01-01

    The LBL/LLNL negative-ion-based neutral beam development program and status are described. The emphasis has shifted in some details since the first symposium in 1977, but our overall objectives remain the same, namely, the development of megawatt d.c. injection systems. Previous emphasis was on a system in which the negative ions were produced by double charge exchange in sodium vapor. At present, the emphasis is on a self-extraction source in which the negative ions are produced on a biased surface imbedded in a plasma. A one-ampere beam will be accelerated to at least 40 keV next year. Studies of negative-ion formation and interactions help provide a data base for the technology program

  8. An overview of the PIREX Proton Irradiation facility and its research program

    Energy Technology Data Exchange (ETDEWEB)

    Victoria, M.; Gavillet, D. [Association EURATOM, Villigen (Switzerland)

    1995-10-01

    The main design characteristics of PIREX (Proton Irradiation Experiment) are described. The facility is installed in the 590 MeV proton beam of the PSI accelerator system. Its main task is the irradiation and testing of fusion reactor candidate materials. Protons of this energy produce simultaneously in the target material displacement damage and impurities, amongst them helium. They can therefore simulate possible synergistic effects between helium and damage that would result from irradiations with the fusion neutrons. The research program being developed includes studies on both materials of technological interest, such as martensitic stainless steels and Mo - based alloys and basic radiation damage research on pure metals. The facility is also being used for actinide transmutation studies, in the so called ATHENA experiment. The main directions of the research program are described and examples of present results are given.

  9. Overview of the U.S. Environmental Protection Agency's Hazardous Air Pollutant Early Reduction Program

    International Nuclear Information System (INIS)

    Laznow, J.; Daniel, J.

    1992-01-01

    Under provision of the Clean Air Act Amendments of 1990 Title III, the EPA has proposed a regulation (Early Reduction Program) to allow a six-year compliance extension from Maximum Achievable Control Technology (MACT) standards for sources that voluntarily reduce emissions of Hazardous Air Pollutants (HAPs) by 90% or more (95% or more for particulates) from a base year of 1987 or later. The emission reduction must be made before the applicable MACT standard is proposed for the source category or be subject to an enforceable commitment to achieve the reduction by January 1, 1994 for sources subject to MACT standards prior to 1994. The primary purpose of this program is to encourage reduction of HAPs emissions sooner than otherwise required. Industry would be allowed additional time in evaluating emission reduction options and developing more cost-effective compliance strategies, although, under strict guidelines to ensure actual, significant and verifiable emission reductions occur

  10. An overview of the US Department of Energy Plant Lifetime Improvement Program

    International Nuclear Information System (INIS)

    Moonka, A.K.; Harrison, D.L.

    1995-01-01

    This paper provides a brief summary of the U.S. Department of Energy's (USDOE's) cooperative effort with the nuclear industry to develop technology to manage the effects of material degradation in systems, structures and components (SSCs) that impact plant safety or can significantly improve plant performance/economics and to establish and demonstrate the license renewal process. Also included are efforts to reduce decontamination/decommission costs, and reduce the uncertainty in long-term service-life decision making. During 1995, the Plant Lifetime Improvement (PLIM) Program was renamed the Commercial Operating Light Water Reactor (COLWR) Program activities are focused on sustaining the LWR option for domestic electricity generation by supporting operation of existing LWRs as long as they are safe, efficient, and economical. The status of the key projects is discussed in this paper

  11. Program director`s overview report for the Office of Health & Environmental Research

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, D. [ed.

    1994-02-01

    LBL performs basic and applied research and develops technologies in support of the Office of Health and Environmental Research`s mission to explore and mitigate the long-term health and environmental consequences of energy use and to advance solutions to major medical challenges. The ability of the Laboratory to engage in this mission depends upon the strength of its core competencies. In addition, there are several key capabilities that are cross-cutting, or underlie, many of the core competencies. Attention is focused on the following: Facilities and resources; research management practices; research in progress; program accomplishments and research highlights; program orientation; work for non-OHER organizations DOE; critical issues; and resource orientation.

  12. NASA Applied Sciences Program. Overview Presentation; Discovering and Demonstrating Innovative and Practical Applications of Earth Science

    Science.gov (United States)

    Irwin, Daniel

    2010-01-01

    Goal 1: Enhance Applications Research Advance the use of NASA Earth science in policy making, resource management and planning, and disaster response. Key Actions: Identify priority needs, conduct applied research to generate innovative applications, and support projects that demonstrate uses of NASA Earth science. Goal 2: Increase Collaboration Establish a flexible program structure to meet diverse partner needs and applications objectives. Key Actions: Pursue partnerships to leverage resources and risks and extend the program s reach and impact. Goal 3:Accelerate Applications Ensure that NASA s flight missions plan for and support applications goals in conjunction with their science goals, starting with mission planning and extending through the mission life cycle. Key Actions: Enable identification of applications early in satellite mission lifecycle and facilitate effective ways to integrate end-user needs into satellite mission planning

  13. Space station environmental control and life support systems test bed program - an overview

    Science.gov (United States)

    Behrend, Albert F.

    As the National Aeronautics and Space Administration (NASA) begins to intensify activities for development of the Space Station, decisions must be made concerning the technical state of the art that will be baselined for the initial Space Station system. These decisions are important because significant potential exists for enhancing system performance and for reducing life-cycle costs. However, intelligent decisions cannot be made without an adequate assessment of new and ready technologies, i.e., technologies which are sufficiently mature to allow predevelopment demonstrations to prove their application feasibility and to quantify the risk associated with their development. Therefore, the NASA has implemented a technology development program which includes the establishment of generic test bed capabilities in which these new technologies and approaches can be tested at the prototype level. One major Space Station subsystem discipline in which this program has been implemented is the environmental control and life support system (ECLSS). Previous manned space programs such as Gemini, Apollo, and Space Shuttle have relied heavily on consumables to provide environmental control and life support services. However, with the advent of a long-duration Space Station, consumables must be reduced within technological limits to minimize Space Station resupply penalties and operational costs. The use of advanced environmental control and life support approaches involving regenerative processes offers the best solution for significant consumables reduction while also providing system evolutionary growth capability. Consequently, the demonstration of these "new technologies" as viable options for inclusion in the baseline that will be available to support a Space Station initial operational capability in the early 1990's becomes of paramount importance. The mechanism by which the maturity of these new regenerative life support technologies will be demonstrated is the Space

  14. Target salt 2025: a global overview of national programs to encourage the food industry to reduce salt in foods.

    Science.gov (United States)

    Webster, Jacqui; Trieu, Kathy; Dunford, Elizabeth; Hawkes, Corinna

    2014-08-21

    Reducing population salt intake has been identified as a priority intervention to reduce non-communicable diseases. Member States of the World Health Organization have agreed to a global target of a 30% reduction in salt intake by 2025. In countries where most salt consumed is from processed foods, programs to engage the food industry to reduce salt in products are being developed. This paper provides a comprehensive overview of national initiatives to encourage the food industry to reduce salt. A systematic review of the literature was supplemented by key informant questionnaires to inform categorization of the initiatives. Fifty nine food industry salt reduction programs were identified. Thirty eight countries had targets for salt levels in foods and nine countries had introduced legislation for some products. South Africa and Argentina have both introduced legislation limiting salt levels across a broad range of foods. Seventeen countries reported reductions in salt levels in foods-the majority in bread. While these trends represent progress, many countries have yet to initiate work in this area, others are at early stages of implementation and further monitoring is required to assess progress towards achieving the global target.

  15. Joint Service Chemical and Biological Defense Program: FY 06-07 Overview

    Science.gov (United States)

    2006-01-01

    Performers Molecular model of human plasma-derived butyryl Electronmicrograph of bacillus spores adhering to cell membrane processes 38866_BATT_TX 11...agents, and radioactive fallout. CPS is integrated with the ship’s Heating, Ventilation, and Air-Conditioning ( HVAC ) systems and provides filtered air...molecules for intervention against protein NTA. • Identify and evaluate effectiveness of spore germination inhibitors. • Expand drug discovery program

  16. Magnetic fusion program in the United States: an overview and perspective

    International Nuclear Information System (INIS)

    Clarke, J.F.

    1978-01-01

    Continuing technical progress in magnetic fusion energy research and a coherent national program involving national laboratories, industry and universities has won strong support from the new Department of Energy. This review presents recent technical progress and examines fusion in relation to other long term energy supply options. Fusion is seen as a technology which, because of its apparently minimal environmental impacts and promise of reasonable cost, has a good chance of competing successfully with the other inexhaustible energy sources

  17. Sample triage : an overview of Environment Canada's program

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, P.; Goldthorp, M.; Fingas, M. [Environment Canada, Ottawa, ON (Canada). Emergencies Science and Technology Division, Environmental Technology Centre, Science and Technology Branch

    2006-07-01

    The Chemical, biological and radiological/nuclear Research and Technology Initiative (CRTI) is a program led by Canada's Department of National Defence in an effort to improve the capability of providing technical and analytical support in the event of a terrorist-related event. This paper summarized the findings from the CRTI Sample Triage Working Group and reviewed information on Environment Canada's triage program and its' mobile sample inspection facility that was designed to help examine samples of hazardous materials in a controlled environment to minimize the risk of exposure. A sample triage program is designed to deal with administrative, health and safety issues by facilitating the safe transfer of samples to an analytical laboratory. It refers to the collation of all results including field screening information, intelligence and observations for the purpose of prioritizing and directing the sample to the appropriate laboratory for analysis. A central component of Environment Canada's Emergency Response Program has been its capacity to respond on site during an oil or chemical spill. As such, the Emergencies Science and Technology Division has acquired a new mobile sample inspection facility in 2004. It is constructed to work with a custom designed decontamination unit and Ford F450 tow vehicle. The criteria and general design of the trailer facility was described. This paper also outlined the steps taken following a spill of hazardous materials into the environment so that potentially dangerous samples could be safety assessed. Several field trials will be carried out in order to develop standard operating procedures for the mobile sample inspection facility. 6 refs., 6 figs., 4 appendices.

  18. An overview of Compassionate Use Programs in the European Union member states.

    Science.gov (United States)

    Balasubramanian, Gayathri; Morampudi, Suman; Chhabra, Pankdeep; Gowda, Arun; Zomorodi, Behsad

    2016-11-01

    The past decade witnessed rapid development of novel drugs and therapeutic biological agents. The marketing authorization for novel therapies is often time consuming and distressing for patients. Earlier clinical trials were the only way to access new drugs under development. However, not every patient meets the enrolment criteria, and participation is difficult for patients with life-threatening, long-lasting or seriously debilitating diseases like rare diseases. Early access programs like "Compassionate Use Program (CUP)" have generated alternative channels for such patients. The European Medical Agency provides regulations and recommendations for compassionate use, upon which every European Union (EU) member state has developed its own rules and regulations. Despite previous reviews and studies, the available information is limited and gaps exist. This literature review explores CUP in 28 EU member states. Data was collected through literature review and use of country-specific search terms from the healthcare domain. Data sources were not limited to databases and articles published in journals, but also included grey literature. The results implied that CUP was present in 20 EU member states (71%). Of 28 EU states, 18 (∼64%) had nationalized regulations and processes were well-defined. Overall, this review identified CUP and its current status and legislation in 28 EU member states. The established legislation for CUP in the EU member states suggest their willingness to adopt processes that facilitate earlier and better access to new medicines. Further research and periodic reviews are warranted to understand the contemporary and future regulatory trends in early access programs.

  19. Sample collection: an overview of the Hydrogeochemical and Stream Sediment Reconnaissance Program

    International Nuclear Information System (INIS)

    Bolivar, S.L.

    1979-01-01

    A Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) for uranium is currently being conducted throughout the conterminous United States and Alaska. The HSSR is part of the National Uranium Resource Evaluation sponsored by the US Department of Energy. This ambitious geochemical reconnaissance program is conducted by four national laboratories: Los Alamos Scientific Laboratory, Lawrence Livermore Laboratory, Oak Ridge Gaseous Diffusion Plant, and Savannah River Laboratory. The program is based on an extensive review of world literature, reconnaissance work done in other countries, and pilot studies conducted by each laboratory. Sample-collection methods and sample density are determined to optimize the probability of detecting potential uranium mineralization. To achieve this aim, each laboratory has developed independent standardized field collection procedures that are designed for its section of the country. Field parameters such as pH, conductivity, climate, geography, and geology are recorded at each site. Most samples are collected at densities of one sample site per 10 to 23 km 2 . The HSSR program has helped to improve existing hydrogeochemical reconnaissance exploration techniques. In addition to providing industry with data that may help to identify potential uranium districts and to extend known uranium provinces, the HSSR also provides multi-element analytical data, which can be used in water quality, soil, sediment, environmental, and base-metal exploration studies

  20. Overview of the National Uranium Resource Evaluation Hydrogeochemical and Stream Sediment Reconnaissance Program

    International Nuclear Information System (INIS)

    Bolivar, S.L.

    1980-01-01

    A Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) for uranium is currently being conducted throughout the conterminous United States and Alaska. The HSSR is part of the National Uranium Resource Evaluation sponsored by the US Department of Energy. This ambitious geochemical reconnaissance program is conducted by four Department of Energy laboratories: Los Alamos Scientific Laboratory, Lawrence Livermore Laboratory, Oak Ridge Gaseous Diffusion Plant, and Savannah River Laboratory. The program is based on an extensive review of world literature, reconnaissance work done in other countries, and pilot studies conducted by each laboratory. Sample-collection methods and sample density are determined to optimize the probability of detecting potential uranium mineralization. To achieve this aim, each laboratory has developed independent standardized field collection procedures that are designed for its section of the country. Field parameters such as pH, conductivity, climate, geography, and geology are recorded at each site. Most areas are sampled at densities of one sample site per 10 to 23 km 2 . The HSSR program has helped to improve existing hydrogeochemical reconnaissance exploration techniques. In addition to providing industry with data that may help to identify potential uranium districts and to extend known uranium provinces, the HSSR also provides multielement analytical data that can be used in water quality, soil, sediment, environmental, and base-metal exploration studies

  1. Overview of the National Uranium Resource Evaluation Hydrogeochemical and Stream Sediment Reconnaissance Program

    International Nuclear Information System (INIS)

    Bolivar, S.L.

    1980-07-01

    A Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) for uranium is currently being conducted throughout the conterminous United States and Alaska. The HSSR is part of the National Uranium Resource Evaluation sponsored by the US Department of Energy. This ambitious geochemical reconnasissance program is conducted by four Department of Energy Laboratories: Los Alamos Scientific Laboratory, Lawrence Livermore Laboratory, Oak Ridge Gaseous Diffusion Plant, and Savannah River Laboratory. Each laboratory was assigned a geographic region of the United States. The program is based on an extensive review of world literature, reconnaissance work done in other countries, and pilot studies conducted by each laboratory. Sample-collection methods and sample density are determined to optimize the probability of detecting potential uranium mineralization. To achieve this aim, each laboratory has developed independent standardized field collection procedures that are designed for its section of the country. Field parameters such as pH, conductivity, climate, geography, and geology are recorded at each site. Most areas are sampled at densities of one sample site per 10 to 23 km 2 . The HSSR program has helped to improve existing hydrogeochemical reconnaissance exploration techniques. In addition to providing industry with data that may help to identify potential uranium districts and to extend known uranium provinces, the HSSR also provides multielement analytical data that can be used in water quality, soil, sediment, environmental, and base-metal exploration studies

  2. Overview of NASA's Space Solar Power Technology Advanced Research and Development Program

    Science.gov (United States)

    Howell, Joe; Mankins, John C.; Davis, N. Jan (Technical Monitor)

    2001-01-01

    Large solar power satellite (SPS) systems that might provide base load power into terrestrial markets were examined extensively in the 1970s by the US Department of Energy (DOE) and the National Aeronautics and Space Administration (NASA). Following a hiatus of about 15 years, the subject of space solar power (SSP) was reexamined by NASA from 1995-1997 in the 'fresh look' study, and during 1998 in an SSP 'concept definition study', and during 1999-2000 in the SSP Exploratory Research and Technology (SERT) program. As a result of these efforts, during 2001, NASA has initiated the SSP Technology Advanced Research and Development (STAR-Dev) program based on informed decisions. The goal of the STAR-Dev program is to conduct preliminary strategic technology research and development to enable large, multi-megawatt to gigawatt-class space solar power (SSP) systems and wireless power transmission (WPT) for government missions and commercial markets (in-space and terrestrial). Specific objectives include: (1) Release a NASA Research Announcement (NRA) for SSP Projects; (2) Conduct systems studies; (3) Develop Component Technologies; (4) Develop Ground and Flight demonstration systems; and (5) Assess and/or Initiate Partnerships. Accomplishing these objectives will allow informed future decisions regarding further SSP and related research and development investments by both NASA management and prospective external partners. In particular, accomplishing these objectives will also guide further definition of SSP and related technology roadmaps including performance objectives, resources and schedules; including 'multi-purpose' applications (commercial, science, and other government).

  3. Research program on nuclear technology and nuclear safety - Overview report 2010

    International Nuclear Information System (INIS)

    Cavedon, J.-M.

    2011-01-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) summarises the program's main points of interest, work done in the year 2010 and the results obtained. The main highlights of the research program, which was co-ordinated by the Paul Scherrer Institute PSI are presented and discussed. Work done within the STARS program on third-generation nuclear power stations is discussed, as is that carried out on probabilistic safety analyses and human reliability. Analysis of activated materials and MOX nuclear fuel assemblies is discussed. A further project examined aging mechanisms in pressure-loaded components. Processes involved in serious accidents and cooling media loss were also examined. Other fluid-dynamic processes involved, along with other factors, are discussed. Work done on the upgrade of the PROTEUS experimental reactor is discussed, as is that done in connection with PSI's hot laboratory and on radiation-induced creeping in structural materials. Fuel cycles and the disposal of radioactive wastes are looked at and the optimisation of safety in sodium-cooled reactors is discussed. Energy economics aspects and national and international co-operation are briefly looked at and work to be done in 2011 is reviewed. A list of current and completed projects completes the report

  4. Overview of the Liquid Argon Cryogenics for the Short Baseline Neutrino Program (SBN) at Fermilab

    CERN Document Server

    Norris, Barry; Chalifour, Michel; Delaney, Mike; Dinnon, Mike; Doubnik, Roza; Geynisman, Michael; Hentschel, Steve; Kim, Min Jeong; Stefanik, Andy; Tillman, Justin; Zuckerbrot, Mike

    2017-01-01

    The Short-Baseline Neutrino (SBN) physics program will involve three LAr-TPC detectors located along the Booster Neutrino Beam (BNB) at Fermilab. This new SBN Program will deliver a rich and compelling physics opportunity, including the ability to resolve a class of experimental anomalies in neutrino physics and to perform the most sensitive search to date for sterile neutrinos at the eV mass-scale through both appearance and disappearance oscillation channels. The Program will be composed of an existing and operational detector known as Micro Boone (170 ton LAr mass) plus two new experiments known as the SBN Near Detector (SBND, ~ 260 ton) and the SBN Far Detector (SBN-FD, ~ 600 tons). Fermilab is now building two new facilities to house the experiments and incorporate all cryogenic and process systems to operate these detectors beginning in the 2018-2019 time frame. The SBN cryogenics are a collaborative effort between Fermilab and CERN. The SBN cryogenic systems for both detectors are composed of several s...

  5. Second line of defense program overview LA-UR-00-5161

    International Nuclear Information System (INIS)

    Knepper, P.L.; Martin, D.D.W.

    2001-01-01

    Full text: The illicit trafficking of nuclear material is a major concern for non-proliferation and global stability. The nuclear Material Protection, Control and Accounting (MPC and A) program provides the first line of defense in protecting nuclear materials within Russia by upgrading safeguards and security measures at Russian nuclear facilities. Second Line of Defense (SLD) is a cooperative program between the Russian Federation State Customs Committee (RF SCC) and the United States Department of Energy (US DOE) to minimize illicit trafficking of restricted nuclear materials through Russian border control points. This partnership was solidified with the signing of a protocol between DOE and the RF SCC in June 1998. The relationship will soon be formalized in a Memorandum of Understanding that will outline the working relationships and commitments to successful implementation of the SLD Program. The Russians first acknowledged the threat of nuclear smuggling at a Nuclear Safety Summit in Moscow in April 1996. Nikolai Kravehenko, head of the Regional Information and Technical Customs Department of the RF SCC, subsequently stated in a July 1998 interview, 'In order to stop trafficking and illegal shipment to other countries we [also] have to tighten security at the facilities and equip our borders with reliable technology.' At the September 1998 U.S.-Russia Presidential Summit, the then Chairman of the RF SCC, Valery Draganov, highlighted the illicit trafficking challenge confronting Russia and requested U.S. assistance. Since 1991, a myriad of cases associated with the diversion and recovery of nuclear materials appear to be linked to the FSU. In the majority of cases, the material's origin was attributed to Russia. With more than 20,000 km of border contiguous to fourteen other countries, and more than 350 customs and border sites, addressing the threat posed by nuclear smuggling in Russia is not only an urgent but also an expansive problem requiring joint U

  6. Overview of JSPS Core-to-Core Program: Forming Research and Educational Hubs of Medical Physics.

    Science.gov (United States)

    Koizumi, Masahiko; Takashina, Masaaki

    To foster medical physicists, we introduce the achievement we made since 2011 under the national research project of the Japan Society for the Promotion of Science (JSPS) Core-to-Core program; 'Forming Research and Educational Hubs of Medical Physics.' On this basis and under the JSPS program, we promoted research and educational exchange with Indiana University (IU) in USA, University of Groningen (The UG) in the Netherland and other cooperating institutions such as University of Minnesota (UM).A total of 23 students and researchers were sent. UG accepted the most among three institutions. In turn, 12 foreign researchers including post-doctor fellows came to Japan for academic seminars or educational lectures.Fifteen international seminars were held; 8 in Japan, 4 in USA, and 3 in the Netherland.Lots of achievement were made through these activities in 5 years. Total of 23 research topics at the international conferences were presented. Total of 12 articles were published in international journals.This program clearly promoted the establishment of international collaboration, and many young researchers and graduate students were exchanged and collaborated with foreign researchers.

  7. Overview of the 2006-2008 JOGMEC/NRCan/Aurora Mallik Gas Hydrate Production Test Program

    Science.gov (United States)

    Yamamoto, K.; Dallimore, S. R.

    2008-12-01

    During the winters of 2007 and 2008 the Japan Oil, Gas and Metals National Corporation (JOGMEC) and Natural Resources Canada (NRCan), with Aurora Research Institute as the operator, carried out an on-shore gas hydrate production test program at the Mallik site, Mackenzie Delta, Northwest Territories, Canada. The prime objective of the program was to verify the feasibility of depressurization technique by drawing down the formation pressure across a 12m perforated gas hydrate bearing section. This project was the second full scale production test at this site following the 2002 Japex/JNOC/GSC et al Mallik research program in which seven participants organizatinos from five countries undertook a thermal test using hot water circulation Field work in 2007 was devoted to establishing a production test well, installing monitoring devices outside of casing, conducting base line geophysical studies and undertaking a short test to gain practical experience prior to longer term testing planned for 2008 . Hydrate-dissociated gas was produced to surface by depressurization achieved by lowering the fluid level with a dowhole pump. However, the operation was terminated 60 hours after the start of the pumping mainly due to sand production problems. In spite of the short period (12.5 hours of ellapsed pumping time), at least 830m3 of the gas was produced and accumulated in the borehole. Sand screens were installed across the perforated interval at the bottom hole for the 2008 program to overcome operational problems encountered in 2007 and achieve sustainable gas production. Stable bottom hole flowing pressures were successfully achieved during a 6 day test with continuous pump operation. Sustained gas production was achieved with rates between 2000- 4000m3/day and cummulative gas volume in the surface of approximately 13,000m3. Temperature and pressure data measured at the bottom hole and gas and water production rates gave positive evidence for the high efficiency of gas

  8. Overview of environmental radiological monitoring program of Institute of Radiation Protection And Dosimetry - IRD

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Sarah Barreto Oliveira de Christo; Peres, Sueli da Silva, E-mail: suelip@ird.gov.br, E-mail: sarah.barreto1@gmail.com [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Radioproteção

    2017-07-01

    As a branch of the Brazilian Nuclear Energy Commission (CNEN), the Institute of Radiation Protection and Dosimetry (IRD) performs extensive activities in the fields of radiation protection, metrology, and dosimetry, as well as specific education, onto a wide operational scope that includes the technical support to national regulatory authorities in the licensing process for nationwide nuclear and radioactive facilities. IRD has several laboratories where are performed radiometric and radiochemical analyses and others radioactivity evaluation procedures in different types of samples obtained in the inspection activities, production of radioactivity metrological standards and reference material by National Laboratory of Metrology of Ionizing Radiation (LMNRI), besides others research activities. In this laboratories can be used sealed or unsealed radioactive sources and radiation-producing devices and are classified with radioactive installations in accordance to national regulations. This way, radioactive liquid effluents can be eventually produced and released into the environment in the course of such activities and an effluent monitoring program to control and reduce the releases to environment is carried out. Additionally, IRD maintains the Radioactive Waste Management Program and Environmental Radiological Monitoring Program (ERMP) in accordance to national regulations requirements. The primary focus of ERMP comprises the validation of the dose prognostics for the public members due to effluents discharge and the provision of consistent projections of the radiation levels at the monitoring sites. In this study, a long term ERMP data survey is discussed, spanning the last thirteen years of activities. On the basis of such discussions and prognostics, it could be observed that the radiological environmental radiological impact due to operation of IRD installations is negligible. (author)

  9. Overview of environmental radiological monitoring program of Institute of Radiation Protection And Dosimetry - IRD

    International Nuclear Information System (INIS)

    Gomes, Sarah Barreto Oliveira de Christo; Peres, Sueli da Silva

    2017-01-01

    As a branch of the Brazilian Nuclear Energy Commission (CNEN), the Institute of Radiation Protection and Dosimetry (IRD) performs extensive activities in the fields of radiation protection, metrology, and dosimetry, as well as specific education, onto a wide operational scope that includes the technical support to national regulatory authorities in the licensing process for nationwide nuclear and radioactive facilities. IRD has several laboratories where are performed radiometric and radiochemical analyses and others radioactivity evaluation procedures in different types of samples obtained in the inspection activities, production of radioactivity metrological standards and reference material by National Laboratory of Metrology of Ionizing Radiation (LMNRI), besides others research activities. In this laboratories can be used sealed or unsealed radioactive sources and radiation-producing devices and are classified with radioactive installations in accordance to national regulations. This way, radioactive liquid effluents can be eventually produced and released into the environment in the course of such activities and an effluent monitoring program to control and reduce the releases to environment is carried out. Additionally, IRD maintains the Radioactive Waste Management Program and Environmental Radiological Monitoring Program (ERMP) in accordance to national regulations requirements. The primary focus of ERMP comprises the validation of the dose prognostics for the public members due to effluents discharge and the provision of consistent projections of the radiation levels at the monitoring sites. In this study, a long term ERMP data survey is discussed, spanning the last thirteen years of activities. On the basis of such discussions and prognostics, it could be observed that the radiological environmental radiological impact due to operation of IRD installations is negligible. (author)

  10. Overview of waste isoltaion safety assessment program and description of source term characterization task at PNL

    International Nuclear Information System (INIS)

    Bradley, D.

    1977-01-01

    A project is being conducted to develop and illustrate the methods and obtain the data necessary to assess the safety of long-term disposal of high-level radioactive waste in geologic formations. The methods and data will initially focus on generic geologic isolation systems but will ultimately be applied to the long-term safety assessment of specific candidate sites that are selected in the NWTS Program. The activities of waste isolation safety assessment (WISAP) are divided into six tasks: (1) Safety Assessment Concepts and Methods, (2) Disruptive Event Analysis, (3) Source Characterization, (4) Transport Modeling, (5) Transport Data and (6) Societal Acceptance

  11. U.S. Department of Energy photovoltaic energy program overview, fiscal year 1999

    Energy Technology Data Exchange (ETDEWEB)

    Weis-Taylor, P.; Moon, S.

    2000-02-28

    This ``annual report'' details the FY 1999 achievements of the US Department of Energy PV Program in the categories of Research and Development, Technology Development, and Systems Engineering and Applications. Highlights include development of a record-breaking concentrator solar cell that is 32.3% efficient; fabrication of a record CIGS (copper indium gallium diselenide) cell at 18.8% efficiency; sharing an R and D 100 award with Siemens Solar Industries and the California Energy Commission for development and deployment of commercial CIS thin-film modules; and support for the efforts of the PV Industry Roadmap Workshop.

  12. Overview of management programs for plutonium-contaminated solid waste in the U.S.A

    International Nuclear Information System (INIS)

    Ramsey, R.W. Jr.; Daly, G.H.

    1975-01-01

    Programs for transuranium-contaminated solid wastes (TRU) in the U.S.A. are emphasizing a reduction in waste generation and the development of appropriate treatments to reduce the volume of wastes requiring interim storage and final disposal. Research and Development is emphasizing the establishment of sufficient information on treatment, hazards and storage to adopt a standardized procedure for handling wastes during an interim retrievable period and for final disposal. Federal responsibility for TRU waste is being proposed except for minimum amounts acceptable for commercial burial

  13. An overview of the United States Department of Energy Plant Lifetime Improvement Program

    International Nuclear Information System (INIS)

    Rosinski, S.T.; Clauss, J.M.; Harrison, D.L.

    2004-01-01

    Since 1985, the U.S. Department of Energy (DOE) has been working with the nuclear industry and the U.S. Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of nuclear power plants through the renewal of operating licenses. This paper focuses primarily on DOE'S Plant Lifetime Improvement (PLIM) Program efforts to develop the technical criteria and bases for effective aging management and lifetime improvement for continued operation of nuclear power plants. This paper describes current projects to resolve generic technical issues, including degradation of long-lived components, reactor pressure vessel (RPV) embrittlement management approaches, and analytical methodologies to characterize RPV integrity. (author)

  14. Overview of the Nuclear Regulatory Commission Low-Level Waste Management Program

    International Nuclear Information System (INIS)

    Bishop, W.P.; Bell, M.J.; Dragonette, K.S.; Adam, J.

    1979-01-01

    Environmental impacts from Table S-3 of 10 CFR Part 51 are included in individual environmental impact statements for LWR's. In response to a U.S. Court of Appeals finding of inadequate documentation to support Table S-3, ''Environmental Survey of Reprocessing and Waste Management Portions of the LWR Fuel Cycle'' (NUREG-0116) and ''Public Comments and Task Force Responses Regarding Environmental Survey of the Reprocessing and Waste Portions of the LWR Fuel Cycle'' (NUREG-0216) were published. As a result of these in-house studies, an interim rule revising Table S-3 has been published. These documents include discussions of shallow land burial of low-level waste, past experiences and sensitivity calculations estimating potential dose commitments from the groundwater migration of the wastes. An NRC task force report (NUREG-0217) examining the Federal and Agreement State programs for regulating commercial low-level waste disposal recommends increasing the federal role in low-level waste disposal. The need to investigate alternatives to shallow land burial is identified. The NRC is developing a radioactive waste management program which includes a plan for the implementation of the task force recommendations, the development of environmental impacts for low-level waste disposal, development of standards and criteria, and the establishment of a regulatory framework and licensing procedures for the disposal of low-level radioactive waste

  15. US waste management overview, new legislation, and status and plans of the disposal program

    International Nuclear Information System (INIS)

    Isaacs, T.

    1988-01-01

    The Nuclear Waste Policy Act of 1982 provided a comprehensive master plan for the United States to locate a nuclear waste repository. Details of this process, which began with 9 sites, are well known. One repository was to be provided with a 70,000 metric ton limit on capacity. Provisions were to be made for transportation and a proposed MRS facility, and for activities leading to the potential siting of a second repository. A decision analysis technique was used by DOE in nominating three repository sites for characterization. The second repository program, which had become a matter of political controversy, was stopped because the first repository would have enough capacity for all commercial spent fuel for some time to come. A court decision to drop the MRS was later overruled. DOE still wants a vigorous international program along with work concerned with any rock medium that can be of potential value to the US repository effort. WIPP will continue to be of interest and emphasis as a repository project in salt for defense transuranic wastes. High-level wastes will not be permanently isolated at WIPP

  16. Overview of a comprehensive environmental monitoring and surveillance program: The role of fish and wildlife

    International Nuclear Information System (INIS)

    Gray, R.H.

    1988-05-01

    Concern about the effects of potential releases from nuclear and non-nuclear activities on the US Department of Energy's Hanford Site in southeastern Washington has evolved over four decades into a comprehensive environmental monitoring and surveillance program. The program includes field sampling, and chemical and physical analyses of air, surface and ground water, fish and wildlife, soil, foodstuffs, and natural vegetation. In addition to monitoring radioactivity in fish and wildlife, population numbers of key species are determined, usually during the breeding season. Data from monitoring efforts are used to assess the environmental impacts of Hanford operations and calculate the overall radiological dose to humans onsite, at the Site perimeter, or residing in nearby communities. Chinook salmon spawning in the Columbia River at Hanford has increased in recent years with a concomitant increase in winter nesting activity of bald eagles (Haliaeetus leucocephalus). An elk (Cervus elaphus) herd, established by immigration in 1972, is also increasing. Nesting Canada goose (Branta canadensis) and great blue heron (Ardea herodias), and various other animals, e.g., mule deer (Odocoileus hemionus) and coyotes (Canis latrans) are common. Measured exposure to penetrating radiation and calculated radiation doses to the public are well below applicable regulatory limits

  17. Overview of research in teaching/education programs of graduate in Biochemistry

    Directory of Open Access Journals (Sweden)

    D.F. Escoto et al

    2014-08-01

    Full Text Available INTRODUCTION: In Brazil, since 1980, there is a tendency among Programs Graduate(PG of specific area, such as Biochemistry, of inserting activities involving teaching /education alongside their area of expertise. In this context, various scientific events ofrelevance in the area have presented sessions dedicated to these matters in theirconferences and meetings. OBJECTIVES: This study aimed to investigate the occurrenceof research lines or areas of concentration teaching/education in 16 PG. MATERIALSAND METHODS: We analyzed 35 courses and divided among doctoral, master’sacademic and professional. Data collection occurred through websites of programs. Theanalysis was performed from the indication of the concentration areas or lines of researchprograms presented in their virtual space. Later, they were classified into two categories:those with and those without research in teaching / education. RESULTS ANDDISCUSSION: After visiting all virtual spaces, the results obtained showed that only 3 PGhave research areas and/or areas of concentration in teaching/education. On 2 PG notfound sites were and other 2 PG nor its research nor their area of concentration. From thequantitative search of PG it was still possible to characterize each line found. Basically, theactivities focus on undergraduate education and the pursuit of new teachingmethodologies, only 1 of the PG aims at continuing formation of teachers of basiceducation. CONCLUSION: These activities contribute significantly to the impact andevaluation of the PG. Perceptibly, these spaces are scarce, however, with national policiesfor the dissemination and popularization of scientific production trend is that they areleveraged.

  18. ORNL long-range environmental and waste management plan: Program overview and summary

    International Nuclear Information System (INIS)

    Bates, L.D.; Berry, J.B.; Butterworth, G.E.

    1988-04-01

    The primary purpose of this report is to provide a thorough and systematic planning document to reflect the continuing process of site assessment, strategy development, and planning for the current and long-term control of environmental issues, waste management practices, and remedial action requirements. The docuemnt also provides an estimate of the resources required to implement the current plan. This document is not intended to be a budget document: it is, however, intended to provide guidance to both Martin Marietta Energy Systems, Inc., and the US Department of Energy (DOE) Management as to the near order of magnitude of the resources (primarily funding requirements) and the time frame required to execute the strategy in the present revision of the plan. The near-term (one to three years) part of the plan is a realistic assessment of the current program and ongoing capital projects and reflects the efforts preceived to be necessary to comply with all current state and federal regulations and DOE orders. It also should be in general agreement with current budget (funding) requests and obligations for these immediate years. Beyond the immediate time frame, the document reflects the strategy and the project and funding estimates as a snapshot at the time of publication. Annual revision will reflect the continuing evoltuion and development of environmental and waste management processes, characterizations, remedial actions, regulations, an strategies for the establishment and conduct of a comprehensive environmental and waste management program. 15 figs., 10 tabs

  19. Online support and education for dementia caregivers: overview, utilization, and initial program evaluation.

    Science.gov (United States)

    Glueckauf, Robert L; Ketterson, Timothy U; Loomis, Jeffrey S; Dages, Pat

    2004-01-01

    Family caregivers of older adults with progressive dementia (e.g., Alzheimer's disease) are confronted with a variety of challenges in providing assistance to their loved ones, such as dealing with persistent, repetitive questions, managing episodes of agitation and aggressive responding, as well as monitoring hygiene and self-care activities. Although professional and governmental organizations have called for the creation of community-based education and support programs, a significant proportion of dementia caregivers in the United States continue to receive little or no formal instruction in responding effectively to these anxiety-provoking situations. This paper describes the development and implementation of Alzheimer's Caregiver Support Online (also known as AlzOnline), an Internet- and telephone-based education and support network for caregivers of individuals with progressive dementia. An outcome analysis of a Robert Wood Johnson Foundation-funded strategic marketing initiative to promote the use of AlzOnline is reviewed, followed by a presentation of the findings of an initial program evaluation. Finally, future directions for online caregiver evaluation research are proposed.

  20. JMJ27, an Arabidopsis H3K9 histone demethylase, modulates defense against Pseudomonas syringae and flowering time.

    Science.gov (United States)

    Dutta, Aditya; Choudhary, Pratibha; Caruana, Julie; Raina, Ramesh

    2017-09-01

    Histone methylation is known to dynamically regulate diverse developmental and physiological processes. Histone methyl marks are written by methyltransferases and erased by demethylases, and result in modification of chromatin structure to repress or activate transcription. However, little is known about how histone methylation may regulate defense mechanisms and flowering time in plants. Here we report characterization of JmjC DOMAIN-CONTAINING PROTEIN 27 (JMJ27), an Arabidopsis JHDM2 (JmjC domain-containing histone demethylase 2) family protein, which modulates defense against pathogens and flowering time. JMJ27 is a nuclear protein containing a zinc-finger motif and a catalytic JmjC domain with conserved Fe(II) and α-ketoglutarate binding sites, and displays H3K9me1/2 demethylase activity both in vitro and in vivo. JMJ27 is induced in response to virulent Pseudomonas syringae pathogens and is required for resistance against these pathogens. JMJ27 is a negative modulator of WRKY25 (a repressor of defense) and a positive modulator of several pathogenesis-related (PR) proteins. Additionally, loss of JMJ27 function leads to early flowering. JMJ27 negatively modulates the major flowering regulator CONSTANS (CO) and positively modulates FLOWERING LOCUS C (FLC). Taken together, our results indicate that JMJ27 functions as a histone demethylase to modulate both physiological (defense) and developmental (flowering time) processes in Arabidopsis. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  1. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway

    Science.gov (United States)

    Ho, Jolene Caifeng; Abdullah, Lissa Nurrul; Pang, Qing You; Jha, Sudhakar; Chow, Edward Kai-Hua; Yang, Henry; Kato, Hiroyuki; Ueda, Jun

    2017-01-01

    Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be critical for the adaptation of cancer cells to the hypoxic microenvironment of solid tumors. Previously, we showed that loss-of-function of the hypoxia-regulated H3K9 methyltransferase G9A attenuates tumor growth. However, the mechanisms by which blockade of G9A leads to a tumor suppressive effect remain poorly understood. We show that G9A is highly expressed in breast cancer and is associated with poor patient prognosis, where it may function as a potent oncogenic driver. In agreement with this, G9A inhibition by the small molecule inhibitor, BIX-01294, leads to increased cell death and impaired cell migration, cell cycle and anchorage-independent growth. Interestingly, whole transcriptome analysis revealed that genes involved in diverse cancer cell functions become hypoxia-responsive upon G9A inhibition. This was accompanied by the upregulation of the hypoxia inducible factors HIF1α and HIF2α during BIX-01294 treatment even in normoxia that may facilitate the tumor suppressive effects of BIX-01294. HIF inhibition was able to reverse some of the transcriptional changes induced by BIX-01294 in hypoxia, indicating that the HIFs may be important drivers of these derepressed target genes. Therefore, we show that G9A is a key mediator of oncogenic processes in breast cancer cells and G9A inhibition by BIX-01294 can successfully attenuate oncogenicity even in hypoxia. PMID:29145444

  2. An overview of the U.S. Department of Energy's program for liquid metal reactor seismic technology

    International Nuclear Information System (INIS)

    Jetter, R.I.; Seidensticker, R.W.

    1988-01-01

    During the past decade, the U.S. Department of Energy (DOE) has sponsored the development of seismic design technology in support of Liquid Metal Reactors (LMR's). This has been accomplished through 1) major projects such as the Fast Flux Test Facility (FFTF) and the Clinch River Breeder Reactor (CRBR), 2) base technology programs and 3) support to the design development of innovative LMR's, SAFR and PRISM. These developments have come in the areas of ground motion definition, soil-structure interaction, seismic isolation, fluid-structure interaction and structural analysis methods and criteria for equipment and components such as piping, reactor core and vessels. The initial developments in seismic design technology by DOE and others were directed toward ensuring that the plant, equipment and components had sufficient seismic resistance to ensure availability after an Operations Basis Earthquake (OBE) and to survive a Safe Shutdown Earthquake (SSE). During this period, the emphasis on conservative design had significant cost impacts. The current focus is directed toward a better understanding of seismic design margins and the development of methods to reduce seismic loads on plant and equipment and to enhance siting flexibility. From this perspective, the DOE is currently reassessing the needs and priorities for future seismic technology development. Coordination with University research programs and ongoing seismic technology development sponsored by other governmental agencies and institutions is an integral part of this planning process. The purpose of this paper is to highlight the current status of DOE's seismic technology program for LMR's and to provide an overview of future areas of interest. (author). 7 refs

  3. U.S. Department of Energy's Regional Carbon Sequestration Partnership Program: Overview

    Science.gov (United States)

    Litynski, J.; Plasynski, S.; Spangler, L.; Finley, R.; Steadman, E.; Ball, D.; Nemeth, K.J.; McPherson, B.; Myer, L.

    2009-01-01

    The U.S. Department of Energy (DOE) has formed a nationwide network of seven regional partnerships to help determine the best approaches for capturing and permanently storing gases that can contribute to global climate change. The Regional Carbon Sequestration Partnerships (RCSPs) are tasked with determining the most suitable technologies, regulations, and infrastructure for carbon capture, transport, and storage in their areas of the country and parts of Canada. The seven partnerships include more than 350 state agencies, universities, national laboratories, private companies, and environmental organizations, spanning 42 states, two Indian nations, and four Canadian provinces. The Regional Partnerships initiative is being implemented in three phases: ???Characterization Phase (2003-2005): The objective was to collect data on CO2 sources and sinks and develop the human capital to support and enable future carbon sequestration field tests and deployments. The completion of this Phase was marked by release of the Carbon Sequestration Atlas of the United States and Canada-Version 1 which included a common methodology for capacity assessment and reported over 3,000GT of storage capacity in saline formations, depleted oil and gas fields, and coal seams.???Validation Phase (2005-2009): The objective is to plan and implement small-scale (1??million tons of CO2) Carbon Capture and Storage (CCS) projects, which will demonstrate that large volumes of CO2 can be injected safely, permanently, and economically into geologic formations representative of large storage capacity. Even though the RCSP Program is being implemented in three phases, it should be viewed as an integrated whole, with many of the goals and objectives transitioning from one phase to the next. Accomplishments and results from the Characterization Phase have helped to refine goals and activities in the Validation and Deployment Phases. The RCSP Program encourages and requires open information sharing among

  4. ATMEA1 Nuclear Power Plant. Overview of the HF engineering program

    International Nuclear Information System (INIS)

    Rivere, Cyril; Mashio, Kenji; Martinez-Pellegrini, Diego

    2015-01-01

    ATMEA, a joint-venture between AREVA and Mitsubishi Heavy Industries has developed the ATMEA1 Pressurized Water Reactor (PWR) Nuclear Island (NI), leveraging both of its shareholders’ proficient technologies, innovations and experiences. The scope of the ATMEA1 PWR development covers the complete scope of engineering works necessary to develop a standard product. As a recently emergent discipline in the field of nuclear plant engineering, Human Factor Engineering (HFE) is one of the challenges which has to be integrated within new plant development process. At early design stages of ATMEA1 development, ATMEA has defined and implemented an extensive NUREG-based HFE program, encompassing HFE Preliminary Analyses, Human-Systems Interfaces (HSI) Design and Verification and Validation (V and V) activities. The HFE Preliminary Analyses are defined through Operating Experience Review (OER), Functional Requirement Analysis and Function Allocation (FRA/FA) and Task Analysis (TA). Human-System Interface (HSI) Design and related V and V activities are based on Control Center, Control Rooms and Human-Machine Interfaces (HMIs). All these steps are implemented within the ATMEA Project through a structured generic documentation basis by a HFE team composed of HF specialists from both AREVA and MHI and managed by ATMEA. ATMEA1 development project aims to develop flexible and robust design and process which can be easily adapted to be compliant to any regulations over the world. U.S. regulatory guidelines related to HFE (e.g. ref. [1] and ref. [2]) were applied as a basis for this project. This paper presents the overall ATMEA1 HFE program content and the related process used to favor its implementation within the Project; through the collaboration between MHI and AREVA under ATMEA lead. A special focus is made on the HFE team composition, roles and responsibilities, the management of interfaces with the relevant engineering disciplines and the tools used to support the HFE

  5. U.S. Department of Energy's Regional Carbon Sequestration Partnership Program: Overview

    Science.gov (United States)

    Litynski, J.; Plasynski, S.; Spangler, L.; Finley, R.; Steadman, E.; Ball, D.; Nemeth, K.J.; McPherson, B.; Myer, L.

    2009-01-01

    The U.S. Department of Energy (DOE) has formed a nationwide network of seven regional partnerships to help determine the best approaches for capturing and permanently storing gases that can contribute to global climate change. The Regional Carbon Sequestration Partnerships (RCSPs) are tasked with determining the most suitable technologies, regulations, and infrastructure for carbon capture, transport, and storage in their areas of the country and parts of Canada. The seven partnerships include more than 350 state agencies, universities, national laboratories, private companies, and environmental organizations, spanning 42 states, two Indian nations, and four Canadian provinces. The Regional Partnerships initiative is being implemented in three phases: ???Characterization Phase (2003-2005): The objective was to collect data on CO2 sources and sinks and develop the human capital to support and enable future carbon sequestration field tests and deployments. The completion of this Phase was marked by release of the Carbon Sequestration Atlas of the United States and Canada-Version 1 which included a common methodology for capacity assessment and reported over 3,000GT of storage capacity in saline formations, depleted oil and gas fields, and coal seams.???Validation Phase (2005-2009): The objective is to plan and implement small-scale (partnerships are currently conducting over 20 small-scale geologic field tests and 11 terrestrial field tests.???Development Phase (2008-2018): The primary objective is the development of large-scale (>1??million tons of CO2) Carbon Capture and Storage (CCS) projects, which will demonstrate that large volumes of CO2 can be injected safely, permanently, and economically into geologic formations representative of large storage capacity. Even though the RCSP Program is being implemented in three phases, it should be viewed as an integrated whole, with many of the goals and objectives transitioning from one phase to the next. Accomplishments

  6. Overview of the Liquid Argon Cryogenics for the Short Baseline Neutrino Program (SBN) at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Norris, Barry [Fermilab; Bremer, Johan [CERN; Chalifour, Michel [Fermilab; Delaney, Mike [Fermilab; Dinnon, Mike [Fermilab; Doubnik, Roza [Fermilab; Geynisman, Michael [Fermilab; Hentschel, Steve [Fermilab; Kim, Min Jeong [Fermilab; Stefanik, Andy [Fermilab; Tillman, Justin [Fermilab; Zuckerbrot, Mike [Fermilab

    2017-01-01

    The Short-Baseline Neutrino (SBN) physics program will involve three LAr-TPC detectors located along the Booster Neutrino Beam (BNB) at Fermilab. This new SBN Program will deliver a rich and compelling physics opportunity, including the ability to resolve a class of experimental anomalies in neutrino physics and to perform the most sensitive search to date for sterile neutrinos at the eV mass-scale through both appearance and disappearance oscillation channels. The Program will be composed of an existing and operational detector known as Micro Boone (170 ton LAr mass) plus two new experiments known as the SBN Near Detector (SBND, ~ 260 ton) and the SBN Far Detector (SBN-FD, ~ 600 tons). Fermilab is now building two new facilities to house the experiments and incorporate all cryogenic and process systems to operate these detectors beginning in the 2018-2019 time frame. The SBN cryogenics are a collaborative effort between Fermilab and CERN. The SBN cryogenic systems for both detectors are composed of several sub-systems: External/Infrastructure (or LN2), Proximity (or LAr), and internal cryogenics. For each detector the External/Infrastructure cryogenics includes the equipment used to store and the cryogenic fluids needed for the operation of the Proximity cryogenics, including the LN2 and LAr storage facilities. The Proximity cryogenics consists of all the systems that take the cryogenic fluids from the external/infrastructure cryogenics and deliver them to the internal at the required pressure, temperature, purity and mass flow rate. It includes the condensers, the LAr and GAr purification systems, the LN2 and LAr phase separators, and the interconnecting piping. The Internal cryogenics is comprised of all the cryogenic equipment located within the cryostats themselves, including the GAr and LAr distribution piping and the piping required to cool down the cryostats and the detectors. These cryogenic systems will be engineered, manufactured, commissioned, and

  7. Overview of Flour Fortification Program with Iron and Folic Acid in Iran

    Directory of Open Access Journals (Sweden)

    Marjan Mahdavi-Roshan

    2017-06-01

    Full Text Available Introduction and purpose: A large percentage of the world population suffers from hidden hunger, which is defined as micronutrients deficiency. Iron deficiency anemia is one of the most common complications of the micronutrients deficiency and there is a lot of effort to deal with this problem. For this purpose, this study aimed to examine the program of flour fortification with iron in Iran. Methods: The cohort, case-control, and clinical trial studies with the search strategies such as iron deficiency anemia, fortification, and micronutrients deficiency, which were conducted until 2015 were included. The data sources entailed PubMed, Ovid, Elsevier Science, Blackwell Synergy, and Google. All the selected studies were available in English and Persian. Results: In several countries, the best method for correction of the iron deficiency anemia is food fortification due to high efficacy and low adverse effects of this method. Bread is a staple food in Iran; therefore, flour fortification was performed in this country. The premix powder containing 30 ppm of iron and 1.5 ppm of folic acid was used for flour fortification. Considering the various types of wealth, the total amount of iron in flour was up to 80 to 85 ppm that may lead to iron poisoning in people with a low socio-economic status because of high bread consumption, as well as the individuals with high socio-economic status since they receive iron from the other resources. Therefore this program was stopped in several provinces due to the mentioned complication. Conclusion: Prior to the implementation of this program, it was essential to carry out abundant pilot studies to investigate the probable complications and problems of this plan. To the best of our knowledge, there is limited number of studies conducted on the adverse effects of iron fortification in Iran; therefore, further studies are recommended in this issue.

  8. Overview of the program on soft x-ray lasers and their applications at Princeton

    International Nuclear Information System (INIS)

    Suckewer, S.; Ilcisin, K.; Princeton Univ., NJ

    1991-05-01

    In the last several years, rapid progress in the development of soft x-ray lasers (SXL) has been observed at a number of laboratories worldwide. Although SXLs are very ''young'' devices they have already been used for microscopy and holography, and new ideas emerging for broader application of SXLs to microscopy, holography and lithography. This paper describes the work at Princeton University on the development of a soft x-ray imaging transmission microscopy using a SXL as a radiation source and work on the development of a novel soft x-ray reflection microscope and its application to biological cell studies and lithography. Progress in the development of a photopumped VUV laser (60 nm), and programs for the development of a small scale SXL and for the application of a powerful subpicosecond KrF laser system are also discussed. 35 refs., 9 figs., 1 tab

  9. ORNL Long-Range Environmental and Waste Management Plan: Program overview and summary

    International Nuclear Information System (INIS)

    Bates, L.D.; Berry, J.B.; Butterworth, G.E.

    1987-12-01

    The primary purpose is to provide a thorough and systematic planning document to reflect the continuing process of site assessment, strategy development, and planning for the current and long-term control of environmental issues, waste management practices, and remedial action requirments. The document also provides an estimate of the resources required to implenent the current plan. As with any document of this nature, the near-term (one to three years) part of the plan is a realistic assessment of the current program and ongoing capital projects and relects the efforts preceived to be necesary to comply with all current state and federal regulations and DOE orders. It also should be in general agreement with current budget (funding) requests and obligations for these immediate years. Beyond the immediate time frame, the document reflects the strategy and the project and funding estimates as a snapshot at the time of publication. 15 figs., 10 tabs

  10. Overview of the Los Alamos National Laboratory Inertial Confinement Fusion Program

    International Nuclear Information System (INIS)

    Harris, D.B.

    1991-01-01

    The Los Alamos Inertial Confinement Fusion (ICF) Program is focused on preparing for a National Ignition Facility. Target physics research is addressing specific issues identified for the Ignition Facility target, and materials experts are developing target fabrication techniques necessary for the advanced targets. We are also working with Lawrence Livermore National Laboratory on the design of the National Ignition Facility target chamber. Los Alamos is also continuing to develop the KrF laser-fusion driver for ICF. We are modifying the Aurora laser to higher intensity and shorter pulses and are working with the Naval Research Laboratory on the development of the Nike KrF laser. 9 refs., 1 fig., 2 tabs

  11. Gas-cooled fast reactor safety - and overview and status of the U.S. program

    International Nuclear Information System (INIS)

    Torri, A.; Buttemer, D.R.

    1981-01-01

    In the revised GCFR Safety Program Plan a quantitative risk limit line has been adopted to establish requirements for the safety related functions and systems. The risk limit line is derived from an interpretation of NRC established licensing requirements, including those for LMFBR's. Multiple barriers to the progression of accident sequences are defined in the form of six Lines of Protection (LOPs). LOPs-1 to 3 are dedicated to accident prevention and represent the normal operating systems, the dedicated safety systems and the inherent design features, respectively. LOPs-4 to 6 are dedicated to the mitigation of core melt accident consequences and include in-vessel accident containment, secondary containment integrity and radiological attenuation, respectively. Cumulative frequency limits and consequence limits are established for each LOP. Design features associated with each LOP are described and the results of supporting safety analyses are summarized. (author)

  12. An overview of the joint FAA/NASA aircraft/ground runway friction program

    Science.gov (United States)

    Yager, Thomas J.

    1989-01-01

    There is a need for information on runways which may become slippery due to various forms and types of contaminants. Experience has shown that since the beginning of all weather aircraft operations, there have been landing and aborted takeoff incidents and/or accidents each year where aircraft have either run off the end or veered off the shoulder of low friction runways. NASA Langley's Landing and Impact Dynamics Branch is involved in several research programs directed towards obtaining a better understanding of how different tire properties interact with varying pavement surface characteristics to produce acceptable performance for aircraft ground handling requirements. One such effort, which was jointly supported by not only NASA and the FAA but by several aviation industry groups including the Flight Safety Foundation, is described.

  13. Overview of Gas Research Institute's industrial utilization research and development program

    Energy Technology Data Exchange (ETDEWEB)

    Tabb, E S

    1982-05-01

    A combination of technical, economic, political, and environmental constraints hamper industry's ability to use natural gas efficiently. Although the industrial sector has the best potential to absorb the current surplus of natural gas, many industrial users are disenchanged with the high cost, low efficiency, and environmental problems associated with the existing inventory of gas-fired process systems. Consequently, it is essential for an organization like Gas Research Institute (GRI), which has a national scope and a mandate to generate energy end-use benefits for the industrial gas consumer, to assume a leadership role in the development program aimed, not only at upgrading the energy efficiency of industrial process equipment, but at increasing its production capability while meeting environmental standards.

  14. An overview of federal government financial involvement in the Canadian nuclear program

    International Nuclear Information System (INIS)

    Wallace, T.W.

    1981-01-01

    The government of Canada has had a financial involvement with the nuclear industry in four areas: nuclear power development, including expenditures for research and development, prototype reactors, and regulation; uranium industry support, including the operations of Eldorado Nuclear Ltd. and the uranium stockpiling program; the financing of nuclear reactors, activities in which the federal government has acted as a banker for the sale of reactors; and heavy water production. Up to 1978-79 total federal expenditures of around $3.4 billion in current collars had been invested. Of this amount, about 56 percent was associated with nuclear power development, 2 percent with uranium industry support, 22 percent with heavy water, and 22 percent with financing reactor sales

  15. Overview of laser experimental program at Centre d'Etudes de Limeil-Valenton

    International Nuclear Information System (INIS)

    Decroisette, M.

    1985-11-01

    In the last four years a great deal of the efforts developed at CEL-V on the laser program concerned the improvement of the existing tools, and the construction of a new high power facility named Phebus. In the field of diagnostics, effort has been concentrated on X-ray metrology, and several actions have been undertaken to develop soft X-ray optics, high space-time resolution cameras and electronic digital readout systems. The advantages of short laser wavelengths have been emphasized for a long time, but it is lately that high efficiency conversion of infrared light was made possible at important energy level with a good reliability. Experiments have been performed at CEL-V at 0.35 μm wavelength mainly devoted to hydrodynamics and energy transport studies. On another hand, X-ray emission have been widely investigated for a better understanding of both plasma energetics and atomic physics

  16. Overview of U.S. LMFBR structural materials mechanical properties program

    International Nuclear Information System (INIS)

    Horak, J.A.; Purdy, C.M.

    This paper presents the objective, scope, and status of the U.S. Department of Energy's Materials and Structures Program to develop a data base on mechanical properties of structural materials for out-of-core structures and components for LMFBRs. Information on the development of a reference data base on materials for the reactor system, reactor enclosure system, primary heat transport system, intermediate heat transport system, and steam generator system is included. In addition, the development of the data and analyses to account for the effects of temperature and stress, as well as water/steam, sodium, and radiation environments, is described. Plans for the development of alternative materials for future out-of-core applications are presented. (author)

  17. Los Alamos National Laboratory transuranic waste characterization and certification program - an overview of capabilities and capacity

    International Nuclear Information System (INIS)

    Rogers, P.S.Z.; Sinkule, B.J.; Janecky, D.R.; Gavett, M.A.

    1997-01-01

    The Los Alamos National Laboratory (LANL) has full capability to characterize transuranic (TRU) waste for shipment to and disposal at the Waste Isolation Pilot Plant (WIPP) for its projected opening. LANL TRU waste management operations also include facilities to repackage both drums of waste found not to be certifiable for WIPP and oversized boxes of waste that must be size reduced for shipment to WIPP. All characterization activities and repackaging are carried out under a quality assurance program designed to meet Carlsbad Area Office (CAO) requirements. The flow of waste containers through characterization operations, the facilities used for characterization, and the electronic data management system used for data package preparation and certification of TRU waste at LANL are described

  18. Hanford long-term high-level waste management program overview

    International Nuclear Information System (INIS)

    Reep, I.E.

    1978-05-01

    The objective is the long-term disposition of the defense high-level radioactive waste which will remain upon completion of the interim waste management program in the mid-1980s, plus any additional high-level defense waste resulting from the future operation of N Reactor and the Purex Plant. The high-level radioactive waste which will exist in the mid-1980s and is addressed by this plan consists of approximately 3,300,000 ft 3 of damp salt cake stored in single-shell and double-shell waste tanks, 1,500,000 ft 3 of damp sludge stored in single-shell and double-shell waste tanks, 11,000,000 gallons of residual liquor stored in double-shell waste tanks, 3,000,000 gallons of liquid wastes stored in double-shell waste tanks awaiting solidification, and 2,900 capsules of 90 SR and 137 Cs compounds stored in water basins. Final quantities of waste may be 5 to 10% greater, depending on the future operation of N Reactor and the Purex Plant and the application of waste treatment techniques currently under study to reduce the inventory of residual liquor. In this report, the high-level radioactive waste addressed by this plan is briefly described, the major alternatives and strategies for long-term waste management are discussed, and a description of the long-term high-level waste management program is presented. Separate plans are being prepared for the long-term management of radioactive wastes which exist in other forms. 14 figures

  19. An overview of an experimental program for testing large reinforced concrete shear walls

    International Nuclear Information System (INIS)

    Farrar, C.R.; Bennett, J.G.

    1989-01-01

    The Seismic Category I Structures Program is being carried out at the Los Alamos National Laboratory under sponsorship of the US Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research. In the class of structure being investigated, the primary lateral load-resisting structural element is the reinforced concrete shear wall. Previous results from microconcrete models indicated that these structures responded to seismic excitations with initial frequencies that were reduced by factors of 2 or more over those calculated based on an uncracked cross-section strength-of-materials approach. Furthermore, though the structures themselves were shown to have sufficient reserve margins, the equipment and piping are designed to response spectra that are based on uncracked cross-sectional member properties, and these spectra may not be inappropriate for actual building responses. The current phase of the program is aimed at verification of these conclusions using conventional concrete structures to demonstrate that previous microconcrete results can be scaled to prototype structures. A new configuration of a shear wall structure was designed and tested to investigate the analytical-experimental differences observed during the previous model testing. Shear wall height-to-length aspect ratios were to vary from 1 to 0.25. Percentage steel ratios were to vary from 0.25% to 0.6% by area, in both horizontal and vertical directions. The test structures are shown in Fig. 1. TRG-1 and -2 were constructed with microconcrete. TRG-3, -4, -5, and -6 were constructed with conventional (19-mm aggregate) concrete. 11 refs., 4 figs

  20. Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.

    Science.gov (United States)

    Ebata, Kevin T; Mesh, Kathryn; Liu, Shichong; Bilenky, Misha; Fekete, Alexander; Acker, Michael G; Hirst, Martin; Garcia, Benjamin A; Ramalho-Santos, Miguel

    2017-01-01

    Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that vitamin C enhances the activity of Tet enzymes in embryonic stem (ES) cells, leading to DNA demethylation and activation of germline genes. We report here that vitamin C induces a remarkably specific demethylation of histone H3 lysine 9 dimethylation (H3K9me2) in naïve ES cells. Vitamin C treatment reduces global levels of H3K9me2, but not other histone methylation marks analyzed, as measured by western blot, immunofluorescence and mass spectrometry. Vitamin C leads to widespread loss of H3K9me2 at large chromosomal domains as well as gene promoters and repeat elements. Vitamin C-induced loss of H3K9me2 occurs rapidly within 24 h and is reversible. Importantly, we found that the histone demethylases Kdm3a and Kdm3b are required for vitamin C-induced demethylation of H3K9me2. Moreover, we show that vitamin C-induced Kdm3a/b-mediated H3K9me2 demethylation and Tet-mediated DNA demethylation are independent processes at specific loci. Lastly, we document Kdm3a/b are partially required for the upregulation of germline genes by vitamin C. These results reveal a specific role for vitamin C in histone demethylation in ES cells and document that DNA methylation and H3K9me2 cooperate to silence germline genes in pluripotent cells.

  1. Overview of the TCV tokamak program: scientific progress and facility upgrades

    Science.gov (United States)

    Coda, S.; Ahn, J.; Albanese, R.; Alberti, S.; Alessi, E.; Allan, S.; Anand, H.; Anastassiou, G.; Andrèbe, Y.; Angioni, C.; Ariola, M.; Bernert, M.; Beurskens, M.; Bin, W.; Blanchard, P.; Blanken, T. C.; Boedo, J. A.; Bolzonella, T.; Bouquey, F.; Braunmüller, F. H.; Bufferand, H.; Buratti, P.; Calabró, G.; Camenen, Y.; Carnevale, D.; Carpanese, F.; Causa, F.; Cesario, R.; Chapman, I. T.; Chellai, O.; Choi, D.; Cianfarani, C.; Ciraolo, G.; Citrin, J.; Costea, S.; Crisanti, F.; Cruz, N.; Czarnecka, A.; Decker, J.; De Masi, G.; De Tommasi, G.; Douai, D.; Dunne, M.; Duval, B. P.; Eich, T.; Elmore, S.; Esposito, B.; Faitsch, M.; Fasoli, A.; Fedorczak, N.; Felici, F.; Février, O.; Ficker, O.; Fietz, S.; Fontana, M.; Frassinetti, L.; Furno, I.; Galeani, S.; Gallo, A.; Galperti, C.; Garavaglia, S.; Garrido, I.; Geiger, B.; Giovannozzi, E.; Gobbin, M.; Goodman, T. P.; Gorini, G.; Gospodarczyk, M.; Granucci, G.; Graves, J. P.; Guirlet, R.; Hakola, A.; Ham, C.; Harrison, J.; Hawke, J.; Hennequin, P.; Hnat, B.; Hogeweij, D.; Hogge, J.-Ph.; Honoré, C.; Hopf, C.; Horáček, J.; Huang, Z.; Igochine, V.; Innocente, P.; Ionita Schrittwieser, C.; Isliker, H.; Jacquier, R.; Jardin, A.; Kamleitner, J.; Karpushov, A.; Keeling, D. L.; Kirneva, N.; Kong, M.; Koubiti, M.; Kovacic, J.; Krämer-Flecken, A.; Krawczyk, N.; Kudlacek, O.; Labit, B.; Lazzaro, E.; Le, H. B.; Lipschultz, B.; Llobet, X.; Lomanowski, B.; Loschiavo, V. P.; Lunt, T.; Maget, P.; Maljaars, E.; Malygin, A.; Maraschek, M.; Marini, C.; Martin, P.; Martin, Y.; Mastrostefano, S.; Maurizio, R.; Mavridis, M.; Mazon, D.; McAdams, R.; McDermott, R.; Merle, A.; Meyer, H.; Militello, F.; Miron, I. G.; Molina Cabrera, P. A.; Moret, J.-M.; Moro, A.; Moulton, D.; Naulin, V.; Nespoli, F.; Nielsen, A. H.; Nocente, M.; Nouailletas, R.; Nowak, S.; Odstrčil, T.; Papp, G.; Papřok, R.; Pau, A.; Pautasso, G.; Pericoli Ridolfini, V.; Piovesan, P.; Piron, C.; Pisokas, T.; Porte, L.; Preynas, M.; Ramogida, G.; Rapson, C.; Rasmussen, J. Juul; Reich, M.; Reimerdes, H.; Reux, C.; Ricci, P.; Rittich, D.; Riva, F.; Robinson, T.; Saarelma, S.; Saint-Laurent, F.; Sauter, O.; Scannell, R.; Schlatter, Ch.; Schneider, B.; Schneider, P.; Schrittwieser, R.; Sciortino, F.; Sertoli, M.; Sheikh, U.; Sieglin, B.; Silva, M.; Sinha, J.; Sozzi, C.; Spolaore, M.; Stange, T.; Stoltzfus-Dueck, T.; Tamain, P.; Teplukhina, A.; Testa, D.; Theiler, C.; Thornton, A.; Tophøj, L.; Tran, M. Q.; Tsironis, C.; Tsui, C.; Uccello, A.; Vartanian, S.; Verdoolaege, G.; Verhaegh, K.; Vermare, L.; Vianello, N.; Vijvers, W. A. J.; Vlahos, L.; Vu, N. M. T.; Walkden, N.; Wauters, T.; Weisen, H.; Wischmeier, M.; Zestanakis, P.; Zuin, M.; the EUROfusion MST1 Team

    2017-10-01

    The TCV tokamak is augmenting its unique historical capabilities (strong shaping, strong electron heating) with ion heating, additional electron heating compatible with high densities, and variable divertor geometry, in a multifaceted upgrade program designed to broaden its operational range without sacrificing its fundamental flexibility. The TCV program is rooted in a three-pronged approach aimed at ITER support, explorations towards DEMO, and fundamental research. A 1 MW, tangential neutral beam injector (NBI) was recently installed and promptly extended the TCV parameter range, with record ion temperatures and toroidal rotation velocities and measurable neutral-beam current drive. ITER-relevant scenario development has received particular attention, with strategies aimed at maximizing performance through optimized discharge trajectories to avoid MHD instabilities, such as peeling-ballooning and neoclassical tearing modes. Experiments on exhaust physics have focused particularly on detachment, a necessary step to a DEMO reactor, in a comprehensive set of conventional and advanced divertor concepts. The specific theoretical prediction of an enhanced radiation region between the two X-points in the low-field-side snowflake-minus configuration was experimentally confirmed. Fundamental investigations of the power decay length in the scrape-off layer (SOL) are progressing rapidly, again in widely varying configurations and in both D and He plasmas; in particular, the double decay length in L-mode limited plasmas was found to be replaced by a single length at high SOL resistivity. Experiments on disruption mitigation by massive gas injection and electron-cyclotron resonance heating (ECRH) have begun in earnest, in parallel with studies of runaway electron generation and control, in both stable and disruptive conditions; a quiescent runaway beam carrying the entire electrical current appears to develop in some cases. Developments in plasma control have benefited from

  2. Mount Elbert Gas Hydrate Stratigraphic Test Well, Alaska North Slope: Overview of scientific and technical program

    Science.gov (United States)

    Hunter, R.B.; Collett, T.S.; Boswell, R.; Anderson, B.J.; Digert, S.A.; Pospisil, G.; Baker, R.; Weeks, M.

    2011-01-01

    scientific research programs can be safely, effectively, and efficiently conducted within ANS infrastructure. The program success resulted in a technical team recommendation to project management to drill and complete a long-term production test within the area of existing ANS infrastructure. If approved by stakeholders, this long-term test would build on prior arctic research efforts to better constrain the potential gas rates and volumes that could be produced from gas hydrate-bearing sand reservoirs. ?? 2010 Elsevier Ltd.

  3. Overview of C-2U FRC Experimental Program and Plans for C-2W

    Science.gov (United States)

    Gota, H.; Binderbauer, M. W.; Tajima, T.; Putvinski, S.; Tuszewski, M.; Dettrick, S.; Korepanov, S.; Smirnov, A.; Thompson, M. C.; Yang, X.; Cappello, M.; Ivanov, A. A.; TAE Team

    2016-10-01

    Tri Alpha Energy's experimental program has been focused on a demonstration of reliable field-reversed configuration (FRC) formation and sustainment, driven by fast ions via high-power neutral-beam (NB) injection. The world's largest compact-toroid experimental devices, C-2 and C-2U, have successfully produced a well-stabilized, sustainable FRC plasma state with NB injection (input power, PNB 10 + MW; 15 keV hydrogen) and end-on coaxial plasma guns. Remarkable improvements in confinement and stability of FRC plasmas have led to further improved fast-ion build up; thereby, an advanced beam-driven FRC state has been produced and sustained for up to 5 + ms (longer than all characteristic system time scales), only limited by hardware and electric supply constraints such as NB and plasma-gun power supplies. To further improve the FRC performance the C-2U device is being replaced by C-2W featuring higher injected NB power, longer pulse duration as well as enhanced edge-biasing systems and substantially upgraded divertors. Main C-2U experimental results and key features of C-2W will be presented. Tri Alpha Energy, Inc.

  4. Overview of C-2W Field-Reversed Configuration Experimental Program

    Science.gov (United States)

    Gota, H.; Binderbauer, M. W.; Tajima, T.; Putvinski, S.; Tuszewski, M.; Dettrick, S.; Korepanov, S.; Romero, J.; Smirnov, A.; Song, Y.; Thompson, M. C.; van Drie, A.; Yang, X.; Ivanov, A. A.; TAE Team

    2017-10-01

    Tri Alpha Energy's research has been devoted to producing a high temperature, stable, long-lived field-reversed configuration (FRC) plasma state by neutral-beam injection (NBI) and edge biasing/control. C-2U experiments have demonstrated drastic improvements in particle and energy confinement properties of FRC's, and the plasma performance obtained via 10 MW NBI has achieved plasma sustainment of up to 5 ms and plasma (diamagnetism) lifetimes of 10 + ms. The emerging confinement scaling, whereby electron energy confinement time is proportional to a positive power of the electron temperature, is very attractive for higher energy plasma confinement; accordingly, verification of the observed Te scaling law will be a key future research objective. The new experimental device, C-2W (now also called ``Norman''), has the following key subsystem upgrades from C-2U: (i) higher injected power, optimum energies, and extended pulse duration of the NBI system; (ii) installation of inner divertors with upgraded edge-biasing systems; (iii) fast external equilibrium/mirror-coil current ramp-up capability; and (iv) installation of trim/saddle coils for active feedback control of the FRC plasma. This paper will review highlights of the C-2W program.

  5. An overview of the HSST Full-Thickness Shallow-Crack Clad Beam Testing Program

    International Nuclear Information System (INIS)

    Keeney, J.A.; Theiss, T.J.; McAfee, W.J.; Bass, B.R.

    1994-01-01

    A testing program is described that will utilize full-thickness clad beam specimens to quantify fracture toughness for shallow flaws in material for which metallurgical conditions are prototypic of those found in reactor pressure vessels (RPVs). The beam specimens are fabricated from a section of an RPV wall that includes weld, plate and clad material. Metallurgical factors potentially influencing fracture toughness for shallow flaws in the beam specimen include material gradients due to welding and cladding applications, as well as material inhomogeneities in welded regions due to reheating in multiple weld passes. Fracture toughness tests focusing on shallow flaws in plate and weld material will also provide data for evaluating the relative influence of absolute and normalized crack depth on constraint conditions. Pretest finite-element analyses are described that provide near-tip stress and strain fields for characterization of constraint in the shallow-crack specimens in terms of the Q-stress. Analysis results predict a constraint loss in the shallow-crack clad beam specimen similar to that determined for a previously tested shallow-crack single-edge notch homogeneous bend specimen with the same normalized crack depth

  6. Uranium removal from soils: An overview from the Uranium in Soils Integrated Demonstration program

    International Nuclear Information System (INIS)

    Francis, C.W.; Brainard, J.R.; York, D.A.; Chaiko, D.J.; Matthern, G.

    1994-01-01

    An integrated approach to remove uranium from uranium-contaminated soils is being conducted by four of the US Department of Energy national laboratories. In this approach, managed through the Uranium in Soils Integrated Demonstration program at the Fernald Environmental Management Project, Fernald, Ohio, these laboratories are developing processes that selectively remove uranium from soil without seriously degrading the soil's physicochemical characteristics or generating waste that is difficult to manage or dispose of. These processes include traditional uranium extractions that use carbonate as well as some nontraditional extraction techniques that use citric acid and complex organic chelating agents such as naturally occurring microbial siderophores. A bench-scale engineering design for heap leaching; a process that uses carbonate leaching media shows that >90% of the uranium can be removed from the Fernald soils. Other work involves amending soils with cultures of sulfur and ferrous oxidizing microbes or cultures of fungi whose role is to generate mycorrhiza that excrete strong complexers for uranium. Aqueous biphasic extraction, a physical separation technology, is also being evaluated because of its ability to segregate fine particulate, a fundamental requirement for soils containing high levels of silt and clay. Interactions among participating scientists have produced some significant progress not only in evaluating the feasibility of uranium removal but also in understanding some important technical aspects of the task

  7. Commercial Building Energy Asset Score System: Program Overview and Technical Protocol (Version 1.0)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Gorrissen, Willy J.

    2013-01-11

    The U.S. Department of Energy (DOE) is developing a national voluntary energy asset score system that includes an energy asset score tool to help building owners evaluate their buildings with respect to the score system. The goal of the energy asset score system is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system will allow building owners and managers to compare their building infrastructure against peers and track building upgrade progress over time. The system can also help other building stakeholders (e.g., building operators, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from their operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset score tool. This report also describes alternative methods that were considered prior to developing the current approach. Finally, this report describes a few features of the program where alternative approaches are still under evaluation.

  8. An overview of the United States Department of Energy plant lifetime improvement program

    International Nuclear Information System (INIS)

    Rosinski, S.T.; Clauss, J.M.; Harrison, D.L.

    1993-01-01

    Today, 109 nuclear power plants provide over 20 percent of the electrical energy generated in the US. The operating license of the first of these plants will expire in the year 2000; one third of the operating licenses will expire by 2010 and the remaining plant licenses are scheduled to expire by 2033. The National Energy Strategy assumes that 70 percent of these plants will continue to operate beyond their current license expiration to assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth. In order to preserve this energy resource in the US three major tasks must be successfully completed: (1) establishment of the regulations, technical standards, and procedures for the preparation and review of a license renewal application; (2) development, verification, and validation of the various technical criteria and bases for needed monitoring, refurbishment, or replacement of plant equipment; and (3) demonstration of the regulatory process. Since 1985, the US Department of Energy (DOE) has been working with the nuclear industry and the US Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of nuclear power plants through the renewal of operating licenses. This paper focuses primarily on DOE's Plant Lifetime Improvement (PLIM) Program efforts to develop the technical criteria and bases for effective aging management and lifetime improvement for continued operation of nuclear power plants. This paper describes current projects to resolve generic technical issues, including degradation of long-lived components, reactor pressure vessel (RPV) embrittlement management approaches, and analytical methodologies to characterize RPV integrity

  9. Next Generation Safeguards Initiative: Overview and Policy Context of UF6 Cylinder Tracking Program

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, Brian D [Los Alamos National Laboratory; Whitaker, J. Michael [ORNL; White-Horton, Jessica L. [ORNL; Durbin, Karyn R. [NNSA

    2012-07-12

    Thousands of cylinders containing uranium hexafluoride (UF{sub 6}) move around the world from conversion plants to enrichment plants to fuel fabrication plants, and their contents could be very useful to a country intent on diverting uranium for clandestine use. Each of these large cylinders can contain close to a significant quantity of natural uranium (48Y cylinder) or low-enriched uranium (LEU) (30B cylinder) defined as 75 kg {sup 235}U which can be further clandestinely enriched to produce 1.5 to 2 significant quantities of high enriched uranium (HEU) within weeks or months depending on the scale of the clandestine facility. The National Nuclear Security Administration (NNSA) Next Generation Safeguards Initiative (NGSI) kicked off a 5-year plan in April 2011 to investigate the concept of a unique identification system for UF{sub 6} cylinders and potentially to develop a cylinder tracking system that could be used by facility operators and the International Atomic Energy Agency (IAEA). The goal is to design an integrated solution beneficial to both industry and inspectorates that would improve cylinder operations at the facilities and provide enhanced capabilities to deter and detect both diversion of low-enriched uranium and undeclared enriched uranium production. The 5-year plan consists of six separate incremental tasks: (1) define the problem and establish the requirements for a unique identification (UID) and monitoring system; (2) develop a concept of operations for the identification and monitoring system; (3) determine cylinder monitoring devices and technology; (4) develop a registry database to support proof-of-concept demonstration; (5) integrate that system for the demonstration; and (6) demonstrate proof-of-concept. Throughout NNSA's performance of the tasks outlined in this program, the multi-laboratory team emphasizes that extensive engagement with industry stakeholders, regulatory authorities and inspectorates is essential to its success.

  10. The histone H3K9 methylation and RNAi pathways regulate normalnucleolar and repeated DNA organization by inhibiting formation ofextrachromosomal DNAs

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Jamy C.; Karpen, Gary H.

    2006-06-15

    In order to identify regulators of nuclear organization, Drosophila mutants in the Su(var)3-9 histone H3K9 methyltransferase, RNAi pathway components, and other regulators of heterochromatin-mediated gene silencing were examined for altered nucleoli and positioning of repeated DNAs. Animals lacking components of the H3K9 methylation and RNAi pathways contained disorganized nucleoli, ribosomal DNA (rDNA) and satellite DNAs. The levels of H3K9 dimethylation (H3K9me2) in chromatin associated with repeated DNAs decreased dramatically in Su(var)3-9 and dcr-2 (dicer-2) mutant tissues compared to wild type. We also observed a substantial increase in extrachromosomal repeated DNAs in mutant tissues. The disorganized nucleolus phenotype depends on the presence of Ligase 4 (Lig4), and ecc DNA formation is not induced by removal of cohesin. We conclude that H3K9 methylation of rDNA and satellites, maintained by Su(var)3-9, HP1, and the RNAi pathway, is necessary for the structural stability of repeated DNAs, which is mediated through suppression of non-homologous end joining (NHEJ). These results suggest a mechanism for how local chromatin structure can regulate genome stability, and the organization of chromosomal elements and nuclear organelles.

  11. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.

    Directory of Open Access Journals (Sweden)

    Jolene Caifeng Ho

    Full Text Available Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be critical for the adaptation of cancer cells to the hypoxic microenvironment of solid tumors. Previously, we showed that loss-of-function of the hypoxia-regulated H3K9 methyltransferase G9A attenuates tumor growth. However, the mechanisms by which blockade of G9A leads to a tumor suppressive effect remain poorly understood. We show that G9A is highly expressed in breast cancer and is associated with poor patient prognosis, where it may function as a potent oncogenic driver. In agreement with this, G9A inhibition by the small molecule inhibitor, BIX-01294, leads to increased cell death and impaired cell migration, cell cycle and anchorage-independent growth. Interestingly, whole transcriptome analysis revealed that genes involved in diverse cancer cell functions become hypoxia-responsive upon G9A inhibition. This was accompanied by the upregulation of the hypoxia inducible factors HIF1α and HIF2α during BIX-01294 treatment even in normoxia that may facilitate the tumor suppressive effects of BIX-01294. HIF inhibition was able to reverse some of the transcriptional changes induced by BIX-01294 in hypoxia, indicating that the HIFs may be important drivers of these derepressed target genes. Therefore, we show that G9A is a key mediator of oncogenic processes in breast cancer cells and G9A inhibition by BIX-01294 can successfully attenuate oncogenicity even in hypoxia.

  12. Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Aishu; Qiu, Yu [Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, 401147 (China); Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, 401147 (China); Cui, Hongjuan [State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716 (China); Fu, Gang, E-mail: fg.ras@hotmail.com [Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, 401147 (China); Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, 401147 (China)

    2015-03-27

    Objective: To explore whether inhibition of H3K9 Methyltransferase G9a could exert an antitumoral effect in oral squamous cell carcinoma (OSCC). Materials and methods: First we checked G9a expression in two OSCC cell lines Tca8113 and KB. Next we used a special G9a inhibitor BIX01294 (BIX) to explore the effect of inhibition of G9a on OSCC in vitro. Cell growth was tested by typlan blue staining, MTT assay and Brdu immunofluorescence staining. Cell autophagy was examined by monodansylcadaverine (MDC) staining, LC3-II immunofluorescence staining and LC3-II western blot assay. Cell apoptosis was checked by FITC Annexin-V and PI labeling, tunnel staining and caspase 3 western blot assay. Finally, the effect of inhibition of G9a on clonogenesis and tumorigenesis capacity of OSCC was analyzed by soft agar growth and xenograft model. Results: Here we showed that G9a was expressed in both Tca8113 and KB cells. Inhibition of G9a using BIX significantly reduced cell growth and proliferation in Tca8113 and KB. Inhibition of G9a induced cell autophagy with conversion of LC3-I to LC3-II and cell apoptosis with the expression of cleaved caspase 3. We also found that inhibition of G9a reduced colony formation in soft agar and repressed tumor growth in mouse xenograph model. Conclusion: Our results suggested that G9a might be a potential epigenetic target for OSCC treatment. - Highlights: • Inhibition of G9a reduced cell growth and proliferation in OSCC cells. • Inhibition of G9a induces autophagy and apoptosis in OSCC cells. • Inhibition of G9a repressed tumor growth in mouse xenograph model.

  13. Overview of recent experimental results from the DIII-D advanced tokamak program

    International Nuclear Information System (INIS)

    Burrell, K.H.

    2003-01-01

    The D III-D research program is developing the scientific basis for advanced tokamak (AT) modes of operation in order to enhance the attractiveness of the tokamak as an energy producing system. Since the last International Atomic Energy Agency (IAEA) meeting, we have made significant progress in developing the building blocks needed for AT operation: 1) We have doubled the magnetohydrodynamic (MHD) stable tokamak operating space through rotational stabilization of the resistive wall mode; 2) Using this rotational stabilization, we have achieved β N H 89 ≥ 10 for 4 τ E limited by the neoclassical tearing mode; 3) Using real-time feedback of the electron cyclotron current drive (ECCD) location, we have stabilized the (m,n) = (3,2) neoclassical tearing mode and then increased β T by 60%; 4) We have produced ECCD stabilization of the (2,1) neoclassical tearing mode in initial experiments; 5) We have made the first integrated AT demonstration discharges with current profile control using ECCD; 6) ECCD and electron cyclotron heating (ECH) have been used to control the pressure profile in high performance plasmas; and 7) We have demonstrated stationary tokamak operation for 6.5 s (36 τ E ) at the same fusion gain parameter of β N H 89 /q 95 2 ≅ 0.4 as ITER but at much higher q 95 = 4.2. We have developed general improvements applicable to conventional and advanced tokamak operating modes: 1) We have an existence proof of a mode of tokamak operation, quiescent H-mode, which has no pulsed, ELM heat load to the divertor and which can run for long periods of time (3.8 s or 25 τ E ) with constant density and constant radiated power; 2) We have demonstrated real-time disruption detection and mitigation for vertical disruption events using high pressure gas jet injection of noble gases; 3) We have found that the heat and particle fluxes to the inner strike points of balanced, double-null divertors are much smaller than to the outer strike points. (author)

  14. Earth2Class Overview: An Innovative Program Linking Classroom Educators and Research Scientists

    Science.gov (United States)

    Passow, M.; Iturrino, G. J.; Baggio, F. D.; Assumpcao, C. M.

    2005-12-01

    The Earth2Class (E2C) workshops, held at the Lamont-Doherty Earth Observatory (LDEO), provide an effective model for improving knowledge, teaching, and technology skills of middle and high school science educators through ongoing interactions with research scientists and educational technology. With support from an NSF GeoEd grant, E2C has developed monthly workshops, web-based resources, and summer institutes in which classroom teachers and research scientists have produced exemplar curriculum materials about a wide variety of cutting-edge geoscience investigations suitable for dissemination to teachers and students. Some of the goals of this program are focused to address questions such as: (1) What aspects of the E2C format and educational technology most effectively connect research discoveries with classroom teachers and their students? (2) What benefits result through interactions among teachers from highly diverse districts and backgrounds with research scientists, and what benefits do the scientists gain from participation? (3) How can the E2C format serve as a model for other research institution-school district partnerships as a mechanism for broader dissemination of scientific discoveries? E2C workshops have linked LDEO scientists from diverse research specialties-seismology, marine geology, paleoclimatology, ocean drilling, dendrochronology, remote sensing, impact craters, and others-with teachers from schools in the New York metropolitan area. Through the workshops, we have trained teachers to enhance content knowledge in the Earth Sciences and develop skills to incorporate new technologies. We have made a special effort to increase the teaching competency of K-12 Earth Sciences educators serving in schools with high numbers of students from underrepresented groups, thereby providing greater role models to attract students into science and math careers. E2C sponsored Earth Science Teachers Conferences, bringing together educators from New York and New

  15. An overview of fiber-to-the-premises (FTTP) product requirements and qualification programs

    Science.gov (United States)

    Gebizlioglu, Osman S.; Gallo, Ernest J.

    2006-04-01

    North American deployments of FTTP architectures have been rapidly increasing. While the FTTP market is being driven by major telecommunications service providers, equipment suppliers have been scrambling to bring products to market that will ensure them a piece of this high-stakes market. In this invited presentation/paper, we propose to examine the technical requirements that are needed to support the new FTTP network with a host of new products that have been in development. To enable service providers select the best new products for FTTP deployment, product selection needs to be based on the analysis and testing of new products for performance and reliability, Telcordia, in its traditional role of telecommunications standards development, has been publishing generic requirements (GR) documents that have been used by suppliers, service providers and the industry at large. Product qualification programs based on the established performance and reliability requirements/standards have been designed to evaluate products to determine if they can 1) withstand the rigors of the outside plant deployment environment and perform for extended periods of time, 2) be upgradeable, and 3) craft friendly. The outside plant is a tough environment to live in. A product must perform under the extreme conditions of cold down -40°C (-40°F) and hot up to 46°C (115°F) with high humidity of 95%, rain, snow, sleet, vibration due to traffic, lightning, heating due to solar loads, high winds, ice, sand storms, and products are even tested to demonstrate if they can continue to operate in an earthquake, a wild fire and a shotgun blast. All FTTP products are not only expected to perform, but they must meet stringent optical performance criteria of low insertion loss and reflectance / return loss at a broad range of wavelengths from 1310, 1490, 1550 and 1625 nm. While the upstream (from the customer to the CO) voice and data transmission is currently planned over 1310-nm wavelength, the

  16. KEY COMPARISON: Final report on CCQM-K9.2: Subsequent key comparison on pH determination of phosphate buffer by Harned cell measurements

    Science.gov (United States)

    Spitzer, Petra; Giera, Janine; Fraga, Isabel C.; Tønnes Jakobsen, Pia; Jensen, Hans D.; Hyllested, Peter; Karpov, Oleg; Kutovoy, Viatcheslav; Nakamura, Susumu; Vospelova, Alena; Zvezdina, Valentina

    2008-01-01

    CCQM-K9.2 was performed supplementary to the key comparison CCQM-K9 on the pH determination of a phosphate buffer with nominal pH ~ 6.9 (at 25 °C). The sample composition was very similar in both comparisons. Only the source of the starting material used for sample preparation was different. The comparison was restricted to the use of the primary method for pH (Harned cell measurement) as defined in the IUPAC Recommendations [2]. The measurement temperatures were 15 °C, 25 °C, 37 °C. CCQM-K9.2, CCQM-K.9 and the first supplementary comparison CCQM-K9.1 [5] are activities of the Electrochemical Working Group (EAWG) of the CCQM. All three comparisons were coordinated by the PTB, Germany. The Danish Primary Laboratory (DPL) successfully took part in the CCQM-K9. Meanwhile the primary set-up for pH in Denmark moved from DPL affiliated to Radiometer Medical to DFM, Denmark. The subsequent comparison allows assessing the degree of equivalence for the measurement of pH at DFM after the move. Due to the interest of other laboratories in demonstrating their progress in pH measurements on the primary level the CCQM-K9.2 supplementary comparison was extended to other participants than DFM, namely NMIJ, VNIIFTRI, INMETRO and CMI. The reported quantity for CCQM-K9.2 was not the pH of the sample but the acidity function at zero chloride molality (see chapter 12). To calculate the pH value from the acidity function it is necessary to know the ionic strength of the sample buffer solution, which was undisclosed by the coordinator. With the exception of the Czech Metrology Institute, CMI, good agreement in the determined acidity function is found between the participants. The results reported by DFM and by PTB agree within their measurement uncertainty at all measurement temperatures. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report

  17. Final report on CCQM-K9.2 : subsequent key comparison on pH determination of phosphate buffer by Harned cell measurements

    OpenAIRE

    Spitzer, Petra; Giera, Janine; Fraga, Isabel Cristina Serta; Jakobsen, Pia Tonnes; Jensen, Hans D.; Hyllested, Peter; Karpov, Oleg; Kutovoy, Viatcheslav; Nakamura, Susumu; Vospelova, Alena; Zvezdina, Valentina

    2008-01-01

    CCQM-K9.2 was performed supplementary to the key comparison CCQM-K9 [1] on the pH determination of a phosphate buffer with nominal pH ~ 6.9 (at 25 °C). The sample composition was very similar in both comparisons. Only the source of the starting material used for sample preparation was different. The comparison was restricted to the use of the primary method for pH (Harned cell measurement) as defined in the IUPAC Recommendations [2]. The measurement temperatures were15 °C, 25 °C , 37...

  18. Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2 in human oral cancer cell line.

    Directory of Open Access Journals (Sweden)

    Daisuke Yamamoto

    2010-09-01

    Full Text Available Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ in human oral cancer cell line resulted in accumulation of decarboxylated S-adenosylmethionine (dcSAM, which acts as a competitive inhibitor of methylation reactions. We anticipated that accumulation of dcSAM impaired methylation reactions and resulted in hypomethylation of genome DNA and histone tails.Global methylation state of genome DNA and lysine residues of histone H3 and H4 tails were assayed by Methylation by Isoschizomers (MIAMI method and western blotting, respectively, in the presence or absence of OAZ expression. Ectopic expression of OAZ mediated hypomethylation of CpG islands of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2. Protein level of DNA methyltransferase 3B (DNMT3B and histone H3K9me specific methyltransferase G9a were down-regulated in OAZ transfectant.OAZ induced hypomethylation of CpG islands of global genome DNA and H3K9me2 by down-regulating DNMT3B and G9a protein level. Hypomethylation of CpG islands of genome DNA and histone H3K9me2 is a potent mechanism of induction of the genes related to tumor suppression and DNA double strand break repair.

  19. Repeat Composition of CenH3-chromatin and H3K9me2-marked heterochromatin in Sugar Beet (Beta vulgaris)

    Czech Academy of Sciences Publication Activity Database

    Kowar, T.; Zakrzewski, F.; Macas, Jiří; Koblížková, Andrea; Viehoever, P.; Weisshaar, B.; Schmidt, T.

    2016-01-01

    Roč. 16, č. 120 (2016) ISSN 1471-2229 R&D Projects: GA ČR GBP501/12/G090 Institutional support: RVO:60077344 Keywords : Centromere * CenH3 * H3K9me2 * Heterochromatin Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.964, year: 2016

  20. Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development

    NARCIS (Netherlands)

    Pedersen, Marianne Terndrup; Kooistra, Susanne Marije; Radzisheuskaya, Aliaksandra; Laugesen, Anne; Johansen, Jens Vilstrup; Hayward, Daniel Geoffrey; Nilsson, Jakob; Agger, Karl; Helin, Kristian

    2016-01-01

    Chromatin-associated proteins are essential for the specification and maintenance of cell identity. They exert these functions through modulating and maintaining transcriptional patterns. To elucidate the functions of the Jmjd2 family of H3K9/H3K36 histone demethylases, we generated conditional

  1. Teachers, Teaching and Educational Effectiveness. Session I: Overview Presentation. Title I Dissemination and Program Improvement. East Coast Seminar.

    Science.gov (United States)

    Anderson, Lorin W.

    This seminar overview presents a summary of widely accepted findings by researchers on the qualities, behaviors, and characteristics of effective teachers. As defined in this paper, an effective teacher is one who can engage students in the learning processes, minimize disruptive behavior, and produce desired learning in a large number of…

  2. Assessing Costs and Benefits of Early Childhood Intervention Programs. Overview and Application to the Starting Early Starting Smart Program. Executive Summary

    National Research Council Canada - National Science Library

    Karoly, Lynn

    2001-01-01

    Agency and program administrators and decisionmakers responsible for implementing early childhood intervention programs are becoming more interested in quantifying the costs and benefits of such programs...

  3. An overview of experimental results obtained under the prestressed concrete nuclear pressure vessel development program at the Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Naus, D.J.

    1979-01-01

    Under the Prestressed Concrete Nuclear Pressure Development Program at the Oak Ridge National Laboratory, various aspects of Prestressed Concrete Pressure Vessels (PCPVs) are investigated with respect to reliability, structural performance, constructability, and economy. These investigations are conducted under the High-Temperature Gas-Cooled Reactor (HTGR) Program and the Gas-Cooled Fast Reactor (GCFR) Program. The objectives are to: (1) provide technical support to ongoing PCPV design activities, (2) contribute to the overall technological data base, and (3) provide independent review and evaluations. Specific areas of interest at present include finite-element analysis development, materials and structural behaviour tests, instrumentation evaluations and development, and structural model tests. The following provides an overview of both the HTGR and GCFR PCPV activities and a summary of recent experimental results

  4. ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients

    Energy Technology Data Exchange (ETDEWEB)

    Sui, W.G. [Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department, 181st Hospital, Guilin, Guangxi (China); He, H.Y. [The Life Science College, Guangxi Normal University, Guilin, Guangxi (China); Yan, Q.; Chen, J.J. [Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department, 181st Hospital, Guilin, Guangxi (China); Zhang, R.H. [The Life Science College, Guangxi Normal University, Guilin, Guangxi (China); Dai, Y. [Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University, Shenzhen, Guangdong (China)

    2013-12-12

    Membranous nephropathy (MN), characterized by the presence of diffuse thickening of the glomerular basement membrane and subepithelial in situ immune complex disposition, is the most common cause of idiopathic nephrotic syndrome in adults, with an incidence of 5-10 per million per year. A number of studies have confirmed the relevance of several experimental insights to the pathogenesis of human MN, but the specific biomarkers of MN have not been fully elucidated. As a result, our knowledge of the alterations in histone methylation in MN is unclear. We used chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) to analyze the variations in a methylated histone (H3K9me3) in peripheral blood mononuclear cells from 10 MN patients and 10 healthy subjects. There were 108 genes with significantly different expression in the MN patients compared with the normal controls. In MN patients, significantly increased activity was seen in 75 H3K9me3 genes, and decreased activity was seen in 33, compared with healthy subjects. Five positive genes, DiGeorge syndrome critical region gene 6 (DGCR6), sorting nexin 16 (SNX16), contactin 4 (CNTN4), baculoviral IAP repeat containing 3 (BIRC3), and baculoviral IAP repeat containing 2 (BIRC2), were selected and quantified. There were alterations of H3K9me3 in MN patients. These may be candidates to help explain pathogenesis in MN patients. Such novel findings show that H3K9me3 may be a potential biomarker or promising target for epigenetic-based MN therapies.

  5. Dissolution behavior of bioactive glass ceramics with different CaO/MgO ratios in SBF-K9 and r-SBF

    Directory of Open Access Journals (Sweden)

    M.U. Hashmi

    2014-08-01

    Full Text Available In the present work, we studied dissolution behavior of three glass ceramics samples each having 34 SiO2–14.5 P2O5–1 CaF2–0.5 MgF2 (%wt and ratio of CaO/MgO varying from 11.5:1 to 1:11.5 in conventional SBF (SBF-K9 and revised SBF (r-SBF that has ionic concentration exactly equal to that of human blood plasma. For that purpose, samples were immersed in fluids for different time periods upto 25 days. Thin film XRD analysis revealed the diffusive nature of the phases on the surfaces of samples after soaking for different time periods in r-SBF. It showed the poor precipitation and small thickness of the HCAp layer on the samples as compared to that in SBF-K9, thus indicating the fitness and sensitivity of r-SBF for in-vitro characterization of samples. AAS, FTIR and EDS revealed slow bonding rate on the surfaces of the samples in r-SBF than that in SBF-K9 that showed the dependence of bond formation on the composition of the materials as well as on the physiological fluid used for in-vitro characterization. The rate of HCAp formation was slower in r-SBF due to more competitive adsorption of CO3− ions to Ca and Mg ions owing to greater amount of CO3− in r-SBF than that in SBF-K9. It shows the importance of CO3− content in the physiological fluids for the in-vitro assessment of samples. So, r-SBF is recommended to be used for assessment of samples to clearly understand their behavior in-vivo.

  6. H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.

    Science.gov (United States)

    Wu, Rentian; Wang, Zhiquan; Zhang, Honglian; Gan, Haiyun; Zhang, Zhiguo

    2017-01-09

    DNA replication is tightly regulated to occur once and only once per cell cycle. How chromatin, the physiological substrate of DNA replication machinery, regulates DNA replication remains largely unknown. Here we show that histone H3 lysine 9 demethylase Kdm4d regulates DNA replication in eukaryotic cells. Depletion of Kdm4d results in defects in DNA replication, which can be rescued by the expression of H3K9M, a histone H3 mutant transgene that reverses the effect of Kdm4d on H3K9 methylation. Kdm4d interacts with replication proteins, and its recruitment to DNA replication origins depends on the two pre-replicative complex components (origin recognition complex [ORC] and minichromosome maintenance [MCM] complex). Depletion of Kdm4d impairs the recruitment of Cdc45, proliferating cell nuclear antigen (PCNA), and polymerase δ, but not ORC and MCM proteins. These results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of pre-initiative complex. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  7. DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells.

    Science.gov (United States)

    Lee, Ju-Kyung; Kim, Keun-Cheol

    2013-09-06

    3-Deazaneplanocin A (DZNep), an epigenetic anticancer drug, leads to the indirect suppression of S-adenosyl methionine-dependent cellular methylations by inhibiting S-adenosyl homocystein (AdoHcy) hydrolase. Although it is well known that DZNep targets the degradation of EZH2 protein, H3K27me3 HMTase, there are still uncertainties about the regulation of other types of HMTases during cell death. In this study, we describe that SETDB1 gene expression was regulated by DZNep treatment in human lung cancer cells. We confirm that DZNep induced growth inhibition and increased the dead cell population of lung cancer cells. DZNep treatment affected histone methylations, including H3K27me3 and H3K9me3, but not H3K4me3. Reduced levels of H3K27me3 and H3K9me3 were related with the decreased EZH2 and SETDB1 proteins. Real time PCR analysis showed that SETDB1 gene expression was decreased by DZNep treatment, but no effect was observed for EZH2 gene expression. We cloned the promoter region of SETDB1 and SUV39H1 genes, and performed luciferase assays. The promoter activity of SETDB1 gene was down regulated by DZNep treatment, whereas no effect on SUV39H1 promoter activity was observed. In conclusion, we suggest that DZNep regulates not only on H3K27me3 HMTase EZH2, but also H3K9 HMTase SETDB1 gene expression at the transcription level, implicating that the mechanism of action of DZNep targets multiple HMTases during the death of lung cancer cells. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Relationship between Gene Body DNA Methylation and Intragenic H3K9me3 and H3K36me3 Chromatin Marks

    OpenAIRE

    Hahn, Maria A.; Wu, Xiwei; Li, Arthur X.; Hahn, Torsten; Pfeifer, Gerd P.

    2011-01-01

    To elucidate the relationship between intragenic DNA methylation and chromatin marks, we performed epigenetic profiling of chromosome 19 in human bronchial epithelial cells (HBEC) and in the colorectal cancer cell line HCT116 as well as its counterpart with double knockout of DNMT1 and DNMT3B (HCT116-DKO). Analysis of H3K36me3 profiles indicated that this intragenic mark of active genes is associated with two categories of genes: (i) genes with low CpG density and H3K9me3 in the gene body or ...

  9. H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2.

    Science.gov (United States)

    Chen, Carol C L; Goyal, Preeti; Karimi, Mohammad M; Abildgaard, Marie H; Kimura, Hiroshi; Lorincz, Matthew C

    2018-01-01

    Phosphorylation of histone H3 at serine 10 (H3S10ph) by Aurora kinases plays an important role in mitosis; however, H3S10ph also marks regulatory regions of inducible genes in interphase mammalian cells, implicating mitosis-independent functions. Using the fluorescent ubiquitin-mediated cell cycle indicator (FUCCI), we found that 30% of the genome in interphase mouse embryonic stem cells (ESCs) is marked with H3S10ph. H3S10ph broadly demarcates gene-rich regions in G1 and is positively correlated with domains of early DNA replication timing (RT) but negatively correlated with H3K9me2 and lamin-associated domains (LADs). Consistent with mitosis-independent kinase activity, this pattern was preserved in ESCs treated with Hesperadin, a potent inhibitor of Aurora B/C kinases. Disruption of H3S10ph by expression of nonphosphorylatable H3.3S10A results in ectopic spreading of H3K9me2 into adjacent euchromatic regions, mimicking the phenotype observed in Drosophila JIL-1 kinase mutants . Conversely, interphase H3S10ph domains expand in Ehmt1 (also known as Glp ) null ESCs, revealing that H3S10ph deposition is restricted by H3K9me2. Strikingly, spreading of H3S10ph at RT transition regions (TTRs) is accompanied by aberrant transcription initiation of genes co-oriented with the replication fork in Ehmt1 -/- and Ehmt2 -/- ESCs, indicating that establishment of repressive chromatin on the leading strand following DNA synthesis may depend upon these lysine methyltransferases. H3S10ph is also anti-correlated with H3K9me2 in interphase murine embryonic fibroblasts (MEFs) and is restricted to intragenic regions of actively transcribing genes by EHMT2. Taken together, these observations reveal that H3S10ph may play a general role in restricting the spreading of repressive chromatin in interphase mammalian cells. © 2018 Chen et al.; Published by Cold Spring Harbor Laboratory Press.

  10. Epigenetic regulation of facultative heterochromatinisation in Planococcus citri via the Me(3)K9H3-HP1-Me(3)K20H4 pathway.

    Science.gov (United States)

    Bongiorni, Silvia; Pasqualini, Barbara; Taranta, Monia; Singh, Prim B; Prantera, Giorgio

    2007-03-15

    Using RNA interference (RNAi) we have conducted a functional analysis of the HP1-like chromobox gene pchet2 during embryogenesis of the mealybug Planococcus citri. Knocking down pchet2 expression results in decondensation of the male-specific chromocenter that normally arises from the developmentally-regulated facultative heterochromatinisation of the paternal chromosome complement. Together with the disappearance of the chromocenter the staining levels of two associated histone modifications, tri-methylated lysine 9 of histone H3 [Me(3)K9H3] and tri-methylated lysine 20 of histone H4 [Me(3)K20H4], are reduced to undetectable levels. Embryos treated with double-stranded RNA (dsRNA) targeting pchet2 also exhibit chromosome abnormalities, such as aberrant chromosome condensation, and also the presence of metaphases that contain 'lagging' chromosomes. We conclude that PCHET2 regulates chromosome behavior during metaphase and is a crucial component of a Me(3)K9H3-HP1-Me(3)K20H4 pathway involved in the facultative heterochromatinisation of the (imprinted) paternal chromosome set.

  11. Swiss Energy research 2007 - Overview from the Heads of the Programs; Energie-Forschung 2007. Ueberblicksberichte der Programmleiter

    Energy Technology Data Exchange (ETDEWEB)

    Calisesi, Y

    2008-04-15

    This comprehensive document issued by the Swiss Federal Office of Energy (SFOE) presents the overview reports elaborated by the heads of the various Swiss energy research programmes. Topics covered include the efficient use of energy, with reports covering energy in buildings, traffic and accumulators, electrical technologies, applications and grids, ambient heat, combined heat and power, cooling, combustion, the 'power station 2000', fuel cells and hydrogen and process engineering. Renewable energy topics reported on include solar heat, photovoltaics, industrial solar energy, biomass and wood energy, hydropower, geothermal heat and wind energy. Nuclear energy topics include safety, regulatory safety research and nuclear fusion. Finally, energy economics basics are reviewed. The report is completed with annexes on the Swiss Energy Research Commission, energy research organisations and a list of important addresses.

  12. Swiss Energy research 2007 - Overview from the Heads of the Programs; Energie-Forschung 2007. Ueberblicksberichte der Programmleiter

    Energy Technology Data Exchange (ETDEWEB)

    Calisesi, Y.

    2008-04-15

    This comprehensive document issued by the Swiss Federal Office of Energy (SFOE) presents the overview reports elaborated by the heads of the various Swiss energy research programmes. Topics covered include the efficient use of energy, with reports covering energy in buildings, traffic and accumulators, electrical technologies, applications and grids, ambient heat, combined heat and power, cooling, combustion, the 'power station 2000', fuel cells and hydrogen and process engineering. Renewable energy topics reported on include solar heat, photovoltaics, industrial solar energy, biomass and wood energy, hydropower, geothermal heat and wind energy. Nuclear energy topics include safety, regulatory safety research and nuclear fusion. Finally, energy economics basics are reviewed. The report is completed with annexes on the Swiss Energy Research Commission, energy research organisations and a list of important addresses.

  13. Cascade annealing: an overview

    International Nuclear Information System (INIS)

    Doran, D.G.; Schiffgens, J.O.

    1976-04-01

    Concepts and an overview of radiation displacement damage modeling and annealing kinetics are presented. Short-term annealing methodology is described and results of annealing simulations performed on damage cascades generated using the Marlowe and Cascade programs are included. Observations concerning the inconsistencies and inadequacies of current methods are presented along with simulation of high energy cascades and simulation of longer-term annealing

  14. Vulvovaginitis - overview

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000897.htm Vulvovaginitis - overview To use the sharing features on this page, please enable JavaScript. Vulvovaginitis or vaginitis is swelling or infection of the ...

  15. Overview of Pre-Flight Physical Training, In-Flight Exercise Countermeasures and the Post-Flight Reconditioning Program for International Space Station Astronauts

    Science.gov (United States)

    Kerstman, Eric

    2011-01-01

    International Space Station (ISS) astronauts receive supervised physical training pre-flight, utilize exercise countermeasures in-flight, and participate in a structured reconditioning program post-flight. Despite recent advances in exercise hardware and prescribed exercise countermeasures, ISS crewmembers are still found to have variable levels of deconditioning post-flight. This presentation provides an overview of the astronaut medical certification requirements, pre-flight physical training, in-flight exercise countermeasures, and the post-flight reconditioning program. Astronauts must meet medical certification requirements on selection, annually, and prior to ISS missions. In addition, extensive physical fitness testing and standardized medical assessments are performed on long duration crewmembers pre-flight. Limited physical fitness assessments and medical examinations are performed in-flight to develop exercise countermeasure prescriptions, ensure that the crewmembers are physically capable of performing mission tasks, and monitor astronaut health. Upon mission completion, long duration astronauts must re-adapt to the 1 G environment, and be certified as fit to return to space flight training and active duty. A structured, supervised postflight reconditioning program has been developed to prevent injuries, facilitate re-adaptation to the 1 G environment, and subsequently return astronauts to training and space flight. The NASA reconditioning program is implemented by the Astronaut Strength, Conditioning, and Rehabilitation (ASCR) team and supervised by NASA flight surgeons. This program has evolved over the past 10 years of the International Space Station (ISS) program and has been successful in ensuring that long duration astronauts safely re-adapt to the 1 g environment and return to active duty. Lessons learned from this approach to managing deconditioning can be applied to terrestrial medicine and future exploration space flight missions.

  16. Overview of an REU program: A case study in gender parity, ethnic diversity, and community college students

    Science.gov (United States)

    Pearson, J. K.; Noriega, G.; Benthien, M. L.

    2017-12-01

    The Undergraduate Studies in Earthquake Information Technology (USEIT) is an REU Internship Program focused in multi-disciplinary, collaborative research offered through the Southern California Earthquake Center (SCEC); a research consortium focused on earthquake science. USEIT is an 8-week intensive undergraduate research program. The program is designed for interns to work as a collaborative engine to solve an overarching real-world earthquake problem referred to as the "Grand Challenge". The interns are organized in teams and paired with mentors that have expertise in their specific task in the Grand Challenge. The program is focused around earthquake system science, where students have the opportunity to use super computers, programming platforms, geographic information systems, and internally designed and developed visualization software. The goal of the USEIT program is to motivate undergraduates from diverse backgrounds towards careers in science and engineering through team-based research in the field of earthquake information technology. Efforts are made to recruit students with diverse backgrounds, taking into consideration gender, ethnic background, socioeconomic standing, major, college year, and institution type (2-year and 4-year colleges). USEIT has a partnership with two local community colleges to recruit underserved students. Our emphasis is to attract students that would 1) grow and develop technical skills, soft skills, and confidence from the program, and 2) provide perspective and innovation to the program. USEIT offers on-campus housing to provide a submerged learning environment, recruits diverse majors to foster interdisciplinary collaboration, maintains a full time in lab mentor for day-to-day intern needs, takes students on field trips to provide context to their research, and plans activities and field trips for team building and morale. Each year metrics are collected through exit surveys, personal statements, and intern experience

  17. K-9 Police Dog Bite

    OpenAIRE

    Vy Han; John R. Marshall

    2017-01-01

    History of present illness: A 30-year-old male who was brought into the emergency department (ED) by police officers after being bitten in the right lower extremity by a police German Shepard after attempting to flee authorities on foot. The patient stated that the dog immediately bit down on his right calf and proceeded to violently shake its head side to side without releasing its grip until police manually pulled the dog off of him. Upon arrival to the ED, he was tachycardic in the 120’...

  18. K-9 Police Dog Bite

    Directory of Open Access Journals (Sweden)

    Vy Han

    2017-01-01

    Full Text Available History of present illness: A 30-year-old male who was brought into the emergency department (ED by police officers after being bitten in the right lower extremity by a police German Shepard after attempting to flee authorities on foot. The patient stated that the dog immediately bit down on his right calf and proceeded to violently shake its head side to side without releasing its grip until police manually pulled the dog off of him. Upon arrival to the ED, he was tachycardic in the 120’s, complaining of severe, throbbing, sharp pain in the right lower extremity, and was neurovascular intact on exam. Significant findings: The photograph is of the anterior compartment of the right lower leg demonstrating multiple deep lacerations with exposed and torn muscle. X-ray showed no foreign body. Discussion: Police dog bites should be treated more cautiously than typical dog bites because these highly-trained dogs are generally larger breeds which are taught to subdue suspects with a bite-and-hold technique rather than bite and release. This can lead to extensive crush injuries, fractures, large caliber lacerations with associated muscle tissue injury and/or severe neurovascular compromise.1 Hence, police dog bites often require provocative diagnostic testing, specialist consultation for possible operative repair, and aggressive irrigation and ultimately admission for intravenous antibiotics.1 This patient’s wound was aggressively irrigated and evaluated by plastic surgery in the ED. He was ultimately admitted for intravenous antibiotics, pain control, wound care, and healing by secondary intention.

  19. K9V6 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  20. K9A1 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  1. KiVa Antibullying Program: Overview of Evaluation Studies Based on a Randomized Controlled Trial and National Rollout in Finland

    Directory of Open Access Journals (Sweden)

    Christina Salmivalli

    2012-12-01

    Full Text Available The effects of a Finnish national school-based antibullying program (KiVa were evaluated in a randomized controlled trial (2007–2009 and during nationwide implementation (since 2009. The KiVa program is been found to reduce bullying and victimization and increase empathy towards victimized peers and self-efficacy to support and defend them. KiVa increases school liking and motivation and contributes to significant reductions in anxiety, depression, and negative peer perceptions. Somewhat larger reductions in bullying and victimization were found in the randomized controlled trial than in the broad rollout, and the largest effects were obtained in primary school (grades 1–6. The uptake of the KiVa program is remarkable, with 90 percent of Finnish comprehensive schools currently registered as program users.

  2. The NASA Electronic Parts and Packaging (NEPP) Program: Overview and the New Tenets for Cost Conscious Mission Assurance on Electrical, Electronic, and Electromechanical (EEE) Parts

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2015-01-01

    The NEPP Program focuses on the reliability aspects of electronic devices (integrated circuits such as a processor in a computer). There are three principal aspects of this reliability: 1) Lifetime, inherent failure and design issues related to the EEE parts technology and packaging; 2) Effects of space radiation and the space environment on these technologies, and; 3) Creation and maintenance of the assurance support infrastructure required for mission success. The NEPP mission is to provide guidance to NASA for the selection and application of microelectronics technologies, to improve understanding of the risks related to the use of these technologies in the space environment, and to ensure that appropriate EEE parts research is performed to meet NASA mission assurance needs. NEPPs FY15 goals are to represent the NASA voice to the greater aerospace EEE parts community including supporting anti-counterfeit and trust, provide relevant guidance to cost-effective missions, aid insertion of advanced (and commercial) technologies, resolve unexpected parts issues, ensure access to appropriate radiation test facilities, and collaborate as widely as possible with external entities. In accordance with the changing mission profiles throughout NASA, the NEPP Program has developed a balanced portfolio of efforts to provide agency-wide assurance for not only traditional spacecraft developments, but also those in-line with the new philosophies emerging worldwide. In this presentation, we shall present an overview of this program and considerations for EEE parts assurance as applied to cost conscious missions.

  3. Overview of decommissioning and decontamination technical information support activities funded by the US Department of Energy's remedial action programs

    International Nuclear Information System (INIS)

    Owen, P.T.

    1986-01-01

    In 1979 the US Department of Energy (DOE) established the Remedial Action Program Information Center (RAPIC) at the Oak Ridge National Laboratory to provide technical information support to the Surplus Facilities Management Program, DOE's national decommissioning and decontamination (D and D) program which is managed by DOE's Richland Operations Office and UNC Nuclear Industries, Inc., and to the other DOE remedial action programs. Specific information activities that RAPIC performs to support the DOE's programs and the D and D community include: maintaining a computerized bibliographic database containing about 4500 annotated citations (about 2000 on D and D) and a database of 1800 contacts involved with remedial action work at radioactively contaminated sites; publishing an annual bibliography, ''Nuclear Facility Decommissioning and Site Remedial Actions, A Selected Bibliography,'' ORNL/EIS-154 (six volumes published); maintaining a document repository and providing copies of requested publications; and performing manual and computerized searches of the technical literature. The most significant RAPIC function is serving as a focal point for D and D information. With the extensive resources at its command, RAPIC is in a unique position to provide a comprehensive information base to the D and D community. DOE makes these services available to foster good public relations and promote cooperation and information exchange

  4. Overview of the U.S. program for the management of spent nuclear fuel and high-level waste

    International Nuclear Information System (INIS)

    Kay, C.E.

    1991-01-01

    An important development in the waste-management program conducted by the U.S. Department of Energy (DOE) was the enactment of the Nuclear Waste Policy Amendments Act of 1987 (Amendments Act). The Amendments Act directs DOE to characterize only one site for the first repository; to develop only one repository at present; and to site, construct, and operate a facility for monitored retrievable storage (MRS), subject to certain conditions. Thus, the system authorized by the Congress consists of a geologic repository, an MRS facility, and a transportation system. Because Congress has streamlined the program by reducing options for the major elements of the system, the DOE will be able to concentrate on the technical activities needed for licensing and on developing an integrated system that is optimized for efficiency and manageability. Therefore, DOE is increasing emphasis on systems integration and on quality assurance. The focus of the program remains permanent disposal in a repository. (author) 4 refs

  5. Investigation of Neutron-induced Reactions at n_TOF: an Overview of the 2009–2012 Experimental Program

    CERN Document Server

    Guerrero, C; Andrzejewski, J; Audouin, L; Barbagallo, M; Bécares, V; Bečvář, F; Belloni, F; Berthoumieux, E; Billowes, J; Boccone, V; Bosnar, D; Brugger, M; Calviani, M; Calviño, F; Cano-Ott, D; Carrapiço, C; Cerutti, F; Chiaveri, E; Chin, M; Colonna, N; Cortés, G; Cortés-Giraldo, M A; Diakaki, M; Domingo-Pardo, C; Duran, I; Dressler, R; Dzysiuk, N; Eleftheriadis, C; Ferrari, A; Fraval, K; Ganesan, S; García, A R; Giubrone, G; Gómez-Hornillos, M B; Gonçalves, I F; González-Romero, E; Griesmayer, E; Gunsing, F; Gurusamy, P; Jenkins, D G; Jericha, E; Kadi, Y; Käppeler, F; Karadimos, D; Kivel, N; Koehler, P; Kokkoris, M; Korschinek, G; Krtička, M; Kroll, J; Langer, C; Lederer, C; Leeb, H; Leong, L S; Losito, R; Manousos, A; Marganiec, J; Martínez, T; Mastinu, P F; Mastromarco, M; Massimi, C; Meaze, M; Mendoza, E; Mengoni, A; Milazzo, P M; Mingrone, F; Mirea, M; Mondelaers, W; Paradela, C; Pavlik, A; Perkowski, J; Pignatari, M; Plompen, A; Praena, J; Quesada, J M; Rauscher, T; Reifarth, R; Riego, A; Roman, F; Rubbia, C; Sarmento, R; Schillebeeckx, P; Schmidt, S; Schumann, D; Tagliente, G; Tain, J L; Tarrío, D; Tassan-Got, L; Tsinganis, A; Valenta, S; Vannini, G; Variale, V; Vaz, P; Ventura, A; Versaci, R; Vermeulen, M J; Vlachoudis, V; Vlastou, R; Wallner, A; Ware, T; Weigand, M; Weiß, C; Wright, T J; Žugec, P

    2014-01-01

    The neutron time-of-flight facility n\\_TOF is operating at CERN (Switzerland) since 2001, having started in 2009 a new campaign with an upgraded spallation target. The ambitious program carried out includes a large number of experiments in nuclear technology, astrophysics, basic physics, detector development and medical applications. This paper is devoted to the physics program at n\\_TOF and the measurements performed between 2009 and 2012. Special attention is given to those experiments that have been most challenging, are more important for a particular field, have reached unprecedented levels of accuracy, or have been carried out for the first time ever.

  6. Mixed alkali neodymium orthoborates: K_9Li_3Nd_3(BO_3)_7 and A_2LiNd(BO_3)_2 (A = Rb, Cs)

    International Nuclear Information System (INIS)

    Chen, Pengyun; Xia, Mingjun; Li, Rukang

    2016-01-01

    Crystals of mixed alkali neodymium orthoborates, K_9Li_3Nd_3(BO_3)_7 and A_2LiNd(BO_3)_2 (A = Rb, Cs) were obtained by spontaneous crystallization. K_9Li_3Nd_3(BO_3)_7 crystallizes in space group P2/c with cell parameters of a = 11.4524(7) Aa, b = 10.1266(6) Aa, c = 12.3116 (10) Aa, β = 122.0090(10) . In the structure, NdO_8 polyhedra share corners and connect with planer BO_3 groups to form infinite [Nd_3B_3O_2_1]_n chains. These chains are linked by additional BO_3 groups to produce a double layer of [Nd_6B_6O_3_8]_n blocks in the ac plane with K and Li ions filled into the cavities. A_2LiNd(BO_3)_2 (A = Rb, Cs) crystallizes in space group Pbcm, with cell parameters of a = 7.113(2) Aa, b = 9.691(3) Aa and c = 10.135(3) Aa for Rb_2LiNd(BO_3)_2, and a = 7.2113(3) Aa, b = 9.9621(4) Aa, and c = 10.3347(4) Aa for Cs_2LiNd(BO_3)_2. In the structure, NdO_8 polyhedra are corner-sharing with each other and further interlinked by BO_3 groups to comprise the infinite [Nd_4B_4O_2_4] sheets in the bc plane, with Rb/Cs and Li ions occupying the interlayered space. The compounds show effective near-IR emission and their associated lifetimes are obtained by fluorescence spectra. (Copyright copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. An Overview of Research Strategies and Findings (1971-1975) of the Kamehameha Early Education Program. Technical Report #66.

    Science.gov (United States)

    Gallimore, Ronald; Tharp, Roland G.

    This report reviews the major lines of investigation of the Kamehameha Early Education Program (KEEP) for the period 1971-75. A brief introductory section describes the selection of initial research strategies, identification of problems, issues in research design (such as internal versus external validity) and problems pertaining to the process…

  8. Overview of Fuel Resources Program – Seawater Uranium Recovery Sponsored by the U.S. Department of Energy

    International Nuclear Information System (INIS)

    Kung, Stephen; Britt, Phillip F.; Gill, Gary A.; Schneider, Erich

    2014-01-01

    Investment strategy: To develop advanced adsorbents that can simultaneously enhance U sorption capacity, selectivity, kinetics, and materials durability to reduce the technology cost and uncertainties; Program goals: To develop lab-scale uranium recovery technology demonstration under marine conditions, and to work with potential commercial/industry partner(s) to establish technolog pricing threshhold

  9. An overview of microbial food safety programs in beef, pork, and poultry from farm to processing in Canada.

    Science.gov (United States)

    Rajić, Andrijana; Waddell, Lisa A; Sargeant, Jan M; Read, Susan; Farber, Jeff; Firth, Martin J; Chambers, Albert

    2007-05-01

    Canada's vision for the agri-food industry in the 21st century is the establishment of a national food safety system employing hazard analysis and critical control point (HACCP) principles and microbiological verification tools, with traceability throughout the gate-to-plate continuum. Voluntary on-farm food safety (OFFS) programs, based in part on HACCP principles, provide producers with guidelines for good production practices focused on general hygiene and biosecurity. OFFS programs in beef cattle, swine, and poultry are currently being evaluated through a national recognition program of the Canadian Food Inspection Agency. Mandatory HACCP programs in federal meat facilities include microbial testing for generic Escherichia coli to verify effectiveness of the processor's dressing procedure, specific testing of ground meat for E. coli O157:H7, with zero tolerance for this organism in the tested lot, and Salmonella testing of raw products. Health Canada's policy on Listeria monocytogenes divides ready-to-eat products into three risk categories, with products previously implicated as the source of an outbreak receiving the highest priority for inspection and compliance. A national mandatory identification program to track livestock from the herd of origin to carcass inspection has been established. Can-Trace, a data standard for all food commodities, has been designed to facilitate tracking foods from the point of origin to the consumer. Although much work has already been done, a coherent national food safety strategy and concerted efforts by all stakeholders are needed to realize this vision. Cooperation of many government agencies with shared responsibility for food safety and public health will be essential.

  10. An overview of intravenous-related medication administration errors as reported to MEDMARX, a national medication error-reporting program.

    Science.gov (United States)

    Hicks, Rodney W; Becker, Shawn C

    2006-01-01

    Medication errors can be harmful, especially if they involve the intravenous (IV) route of administration. A mixed-methodology study using a 5-year review of 73,769 IV-related medication errors from a national medication error reporting program indicates that between 3% and 5% of these errors were harmful. The leading type of error was omission, and the leading cause of error involved clinician performance deficit. Using content analysis, three themes-product shortage, calculation errors, and tubing interconnectivity-emerge and appear to predispose patients to harm. Nurses often participate in IV therapy, and these findings have implications for practice and patient safety. Voluntary medication error-reporting programs afford an opportunity to improve patient care and to further understanding about the nature of IV-related medication errors.

  11. Rapid, autonomous analysis of He spectra I: Overview of the RadID program, user experience, and structure

    Energy Technology Data Exchange (ETDEWEB)

    Gosnell, Thomas B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chavez, Joseph R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Rowland, Mark S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wong, James L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-02-26

    RadID is a new gamma-ray spectrum analysis program for rapid screening of HPGe gamma-ray data to reveal the presence of radionuclide signatures. It is an autonomous, rule-based heuristic system that can identify well over 200 radioactive sources with particular interest in uranium and plutonium characteristics. It executes in about one second. RadID does not require knowledge of the detector efficiency, the source-to-detector distance, or the geometry of the inspected radiation source—including any shielding. In this first of a three-document series we sketch the RadID program’s origin, its minimal requirements, the user experience, and the program operation.

  12. Centennial Challenges Program Overview: How NASA Successfully Involves the General Public in the Solving of Current Technology Gaps

    Science.gov (United States)

    Roman, Monsi C.; Kim, Tony; Sudnik, Janet; Sivak, Amy; Porter, Molly; Cylar, Rosaling; Cavanaugh, Dominique; Krome, Kim

    2017-01-01

    The National Aeronautics and Space Administration (NASA) Centennial Challenges Program, part of the Space Technology Mission Directorate (STMD), addresses key technology needs of NASA and the nation, while facilitating new sources of innovation outside the traditional community. This is done by the direct engagement of the public at large, through the offering of Congressional authorized prize purses and associated challenges developed by NASA and the aerospace community and set up as a competition awarding the prize money for achieving the specified technology goal.

  13. Probability-based load combinations for design of category I structures - overview of research program and recent results

    International Nuclear Information System (INIS)

    Reich, M.; Hwang, H.

    1984-01-01

    This paper discusses the probability-based load combinations for the program dealing with the design of Category I structures, currently being worked on at Brookhaven National Laboratory (BNL) for the Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission (NRC). The objective of this program is to develop a probabilistic approach for the safety evaluations of reactor containments and other seismic Category I structures subjected to multiple static and dynamic loadings. Furthermore, on the basis of the developed probabilistic approach, a load combination methodology for the design of seismic Category I structures will also be established. The major tasks of this program are: (1) establish probabilistic representations for various loads and structural resistance, (2) select appropriate structural analysis methods and identify limit states of structures, (3) develop a reliability analysis method applicable to nuclear structures, (4) apply the developed methodology to existing Category I structures in order to evaluate the reliability levels implied in the current design criteria, and (5) recommend load combination design criteria for Category I structures. When the program is completed, it will be possible to (1) provide a method that can evaluate the safety margins of existing containment and other Category I structures and (2) recommended probability-based load combinations and load factors for the design of Category I structures. At the present time, a reliability analysis method for seismic Category I concrete structures has been completed. By utilizing this method, it is possible to evaluate the safety of structures under various static and dynamic loads. In this paper, results of a reliability analysis of a realistic reinforced concrete containment structure under dead load, accidental pressure, and earthquake ground acceleration are presented to demonstrate the feasibility of the methodology. (orig.)

  14. Fatigue and fracture: Overview

    Science.gov (United States)

    Halford, G. R.

    1984-01-01

    A brief overview of the status of the fatigue and fracture programs is given. The programs involve the development of appropriate analytic material behavior models for cyclic stress-strain-temperature-time/cyclic crack initiation, and cyclic crack propagation. The underlying thrust of these programs is the development and verification of workable engineering methods for the calculation, in advance of service, of the local cyclic stress-strain response at the critical life governing location in hot section compounds, and the resultant crack initiation and crack growth lifetimes.

  15. Research program on nuclear technology and nuclear safety - Overview report 2010; Forschungsprogramm Kerntechnik und Nukleare Sicherheit. Ueberblicksbericht 2010

    Energy Technology Data Exchange (ETDEWEB)

    Cavedon, J.-M.

    2011-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) summarises the program's main points of interest, work done in the year 2010 and the results obtained. The main highlights of the research program, which was co-ordinated by the Paul Scherrer Institute PSI are presented and discussed. Work done within the STARS program on third-generation nuclear power stations is discussed, as is that carried out on probabilistic safety analyses and human reliability. Analysis of activated materials and MOX nuclear fuel assemblies is discussed. A further project examined aging mechanisms in pressure-loaded components. Processes involved in serious accidents and cooling media loss were also examined. Other fluid-dynamic processes involved, along with other factors, are discussed. Work done on the upgrade of the PROTEUS experimental reactor is discussed, as is that done in connection with PSI's hot laboratory and on radiation-induced creeping in structural materials. Fuel cycles and the disposal of radioactive wastes are looked at and the optimisation of safety in sodium-cooled reactors is discussed. Energy economics aspects and national and international co-operation are briefly looked at and work to be done in 2011 is reviewed. A list of current and completed projects completes the report.

  16. Overview of the U.S. DOE Hydrogen Safety, Codes and Standards Program. Part 4: Hydrogen Sensors; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Buttner, William J.; Rivkin, Carl; Burgess, Robert; Brosha, Eric; Mukundan, Rangachary; James, C. Will; Keller, Jay

    2016-12-01

    Hydrogen sensors are recognized as a critical element in the safety design for any hydrogen system. In this role, sensors can perform several important functions including indication of unintended hydrogen releases, activation of mitigation strategies to preclude the development of dangerous situations, activation of alarm systems and communication to first responders, and to initiate system shutdown. The functionality of hydrogen sensors in this capacity is decoupled from the system being monitored, thereby providing an independent safety component that is not affected by the system itself. The importance of hydrogen sensors has been recognized by DOE and by the Fuel Cell Technologies Office's Safety and Codes Standards (SCS) program in particular, which has for several years supported hydrogen safety sensor research and development. The SCS hydrogen sensor programs are currently led by the National Renewable Energy Laboratory, Los Alamos National Laboratory, and Lawrence Livermore National Laboratory. The current SCS sensor program encompasses the full range of issues related to safety sensors, including development of advance sensor platforms with exemplary performance, development of sensor-related code and standards, outreach to stakeholders on the role sensors play in facilitating deployment, technology evaluation, and support on the proper selection and use of sensors.

  17. Green power programs in Canada : 2002 : Overview of Government green power policies, utility green power development programs, green power and certificate marketing initiatives, and their benefits

    International Nuclear Information System (INIS)

    Bramley, M.; Boustie, S.; Vadgama, J.; Wieler, C.; Pape-Salmon, A.; Holmes, R.

    2003-11-01

    Green power is generally defined as electricity produced from renewable sources, and whose production has low adverse impacts on the environment, human health and communities. Green power has near-zero greenhouse gas (GHG) emissions and includes sources such as wind, hydro, and solar power. Green power offers several environmental benefits, as well as the enhancement of energy security, regional development, economic diversification and the creation of skilled jobs. There are four categories of programs related to green power development in Canada: government green power policies, utility green power development programs, green power marketing initiatives, and green power certificate marketing initiatives. Most of the activities associated with these four categories in 2002 were discussed in this report. However, difficulties with quantification prevented the inclusion of some green power activities in the report, such as (1) the generation of green power not certified or identified by the generator as green power, (2) industry or residential self-generation, (3) net metering, and (4) small government programs. Each category was presented in detail. The information included in the report was based on surveys sent to each program proponent. Follow-up communications and other publicly available information was also included. New programs operating in 2003 or currently under development were listed. refs., 8 tabs

  18. Modelling Overview

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Vesterager, Johan

    This report provides an overview of the existing models of global manufacturing, describes the required modelling views and associated methods and identifies tools, which can provide support for this modelling activity.The model adopted for global manufacturing is that of an extended enterprise s...

  19. Introductory Overviews

    NARCIS (Netherlands)

    Jakeman, A.J.; Hamilton, S.H.; Athanasiadis, I.N.; Pierce, S.A.

    2015-01-01

    Introductory Overview articles are designed to provide introductory level background to key themes and topics that caters to the eclectic readership of EMS. It is envisaged that these articles will help to break down barriers to shared understanding and dialogue within multidisciplinary teams, and

  20. Conference overview

    Indian Academy of Sciences (India)

    It had 17 plenary talks and as a new feature it also had 8 short talks which ..... absence of black holes, long-term simulations are possible and quantitative .... [3] For a brief overview, see The Nag Memorial Lecture by Ashoke Sen at the Inst-.

  1. An Overview of the NASA Energy and Water cycle Study (NEWS) and the North American Water Program (NAWP)

    Science.gov (United States)

    Houser, P. R.

    2014-12-01

    NEWS: 10 years ago, NASA established the NASA Energy and Water-cycle Study (NEWS), whose long-term grand challenge is to document and enable improved, observationally based, predictions of water and energy cycle consequences of Earth system variability and change. The NEWS program builds upon existing NASA-supported basic research in atmospheric physics and dynamics, radiation, climate modeling, and terrestrial hydrology. While these NASA programs fund research activities that address individual aspects of the global energy and water cycles, they are not specifically designed to generate a coordinated result. NEWS developed the first coordinated attempt to describe the complete global energy and water cycle using existing and forthcoming satellite and ground based observations, and laying the foundation for essential NEWS developments in model representations of atmospheric energy and water exchange processes. This comprehensive energy and water data analysis program exploited crucial datasets, some requiring complete re-processing, and new satellite measurements. NAWP: Dramatically changing climates has had an indelible impact on North America's water crisis. To decisively address these challenges, we recommend that NAWP coalesce an interdisciplinary, international and interagency effort to make significant contributions to continental- to decision-scale hydroclimate science and solutions. By entraining, integrating and coordinating the vast array of interdisciplinary observational and prediction resources available, NAWP will significantly advance skill in predicting, assessing and managing variability and changes in North American water resources. We adopt three challenges to organize NAWP efforts. The first deals with developing a scientific basis and tools for mitigating and adapting to changes in the water supply-demand balance. The second challenge is benchmarking; to use incomplete and uncertain observations to assess water storage and quality dynamics, and

  2. The current state of inservice testing programs at U.S. Nuclear Power Plants - a regulatory overview

    International Nuclear Information System (INIS)

    Campbell, P.; Colaccino, J.

    1994-01-01

    Information is provided on inservice testing (IST) of pumps and valves at U.S. nuclear power plants to provide consistency in the implementation of regulatory requirements and to enhance communications among utility licensees who may have, like NSSS vendors, similar kinds and numbers of components or comparable IST programs. Documents discussed include the ASME Operation and Maintenance Standards Parts 6 and 10 (covering inservice testing of pumps and valves in light water reactor power plants), the draft NUREG-1482, Guidelines for Inservice Testing at Nuclear Power Plants (including review comments by Nuclear Management and Resource Council), and applicable Licensee Event Reports including summaries of several reports relating to IST

  3. The Royal College of Pathologists of Australasia Quality Assurance Program: Immunohistochemistry Breast Marker Audit Overview 2005-2015.

    Science.gov (United States)

    Haffajee, Zenobia Ayesha Mohamed; Kumar, Beena; Francis, Glenn; Peck, Martyn; Badrick, Tony

    2017-11-20

    The Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) Anatomical Pathology provides a comprehensive External Quality Assurance (EQA) exercise to review the reporting of immunohistochemistry (IHC) and in-situ hybridization (ISH) breast markers through an audit of clinical results. The aim of this exercise was to provide information regarding the quality of breast marker testing within clinical laboratories from 2005 to 2015. This comprehensive audit included estrogen, progesterone, and HER2 marker reporting. This was an important quality assurance activity established in response to ongoing difficulties experienced in laboratories in this area of testing.

  4. Overview of the Quality Assurance Program Applied to the Performance Assessment of the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    Pickering, S.Y.

    1999-01-01

    The Waste Isolation Pilot Plant (WIPP) is the first deep geologic repository for radioactive waste disposal in the world to be certified by a regulator. Rigorous, nuclear-industry quality assurance (QA) requirements were imposed by the US Environmental Protection Agency. As the Scientific Advisor to the US Department of Energy, Sandia National Laboratories applied these standards to the experimental studies and performance assessment used in the certification process. The QA program ensured that activities conducted by SNL were traceable, transparent, reviewed, reproducible, and retrievable. As a result, regulators and stakeholders were able to evaluate and ultimately certify and accept the WIPP

  5. Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways

    Science.gov (United States)

    Tang, Dongmei; Lin, Qin; He, Yingzi; Chai, Renjie; Li, Huawei

    2016-01-01

    The activation of neuromast (NM) supporting cell (SC) proliferation leads to hair cell (HC) regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of H3K9me2 in HC regeneration after HC loss remains poorly understood. In this study, we focused on the role of H3K9me2 in HC regeneration following neomycin-induced HC loss. To investigate the effects of H3K9me2 in HC regeneration, we took advantage of the G9a/GLP-specific inhibitor BIX01294 that significantly reduces the dimethylation of H3K9. We found that BIX01294 significantly reduced HC regeneration after neomycin-induced HC loss in the zebrafish lateral line. BIX01294 also significantly reduced the proliferation of NM cells and led to fewer SCs in the lateral line. In situ hybridization showed that BIX01294 significantly down-regulated the Wnt and Fgf signaling pathways, which resulted in reduced SC proliferation and HC regeneration in the NMs of the lateral line. Altogether, our results suggest that down-regulation of H3K9me2 significantly decreases HC regeneration after neomycin-induced HC loss through inactivation of the Wnt/β-catenin and Fgf signaling pathways. Thus H3K9me2 plays a critical role in HC regeneration. PMID:27303264

  6. Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Dongmei eTang

    2016-05-01

    Full Text Available The activation of neuromast supporting cell (SC proliferation leads to hair cell (HC regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of H3K9me2 in HC regeneration after HC loss remains poorly understood. In this study, we focused on the role of H3K9me2 in HC regeneration following neomycin-induced HC loss. To investigate the effects of H3K9me2 in HC regeneration, we took advantage of the G9a/GLP-specific inhibitor BIX01294 that significantly reduces the dimethylation of H3K9. We found that BIX01294 significantly reduced HC regeneration after neomycin-induced HC loss in the zebrafish lateral line. BIX01294 also significantly reduced the proliferation of neuromast cells and led to fewer SCs in the lateral line. In situ hybridization showed that BIX01294 significantly down-regulated the Wnt and Fgf signaling pathways, which resulted in reduced SC proliferation and HC regeneration in the neuromasts of the lateral line. Altogether, our results suggest that down-regulation of H3K9me2 significantly decreases HC regeneration after neomycin-induced HC loss through inactivation of the Wnt/β-catenin and Fgf signaling pathways. Thus H3K9me2 plays a critical role in HC regeneration.

  7. Feasibility of and methodology for thermal annealing an embrittled reactor vessel. Volume 1. Program overview. Final report

    International Nuclear Information System (INIS)

    Mager, T.R.

    1983-01-01

    An EPRI sponsored program was carried out by Westinghouse to determine the extent of fracture toughness recovery as a function of annealing time and temperature for neutron embrittlement sensitive reactor vessel material and to develop an optimal thermal anneal procedure for field applications. Program materials were three weldments fabricated by Combustion Engineering, Inc., from the same heat of A533 Grade B Class 1 plate material and the same heat of MnMoNi weld wire. The only variables were the target copper level and the welding flux which was Linde Grade 80 and Linde 0091. Weldments of 0.22, 0.36, and 0.41 wt % copper were produced. It was concluded from this study that excellent recovery of all properties could be achieved by annealing at 850 0 F (454 0 C) and above for 168 hours. Such an annealing resulted in ductile-brittle transition temperature shift recovery of 80 to 100%, and reirradiation after this annealing indicated that the ductile-brittle transition temperature shift appears to continue at the rate which would have been expected had no anneal been performed. System limitations were identified for both wet and dry annealing methods

  8. Measuring the accomplishments of public participation programs: Overview of a methodological study performed for DOE's Office of Environmental Management

    International Nuclear Information System (INIS)

    Schweitzer, M.; Carnes, S.A.; Peelle, E.B.; Wolfe, A.K.

    1997-01-01

    Recently, staff at Oak Ridge National Laboratory performed a study for the Office of Intergovernmental and Public Accountability within the U.S. Department of Energy's (DOE) Office of Environmental Management (EM), examining how to measure the success of public participation programs. While the study began with a thorough literature review, the primary emphasis of this research effort was on getting key stakeholders to help identify attributes of successful public participation in EM activities and to suggest how those attributes might be measured. Interviews were conducted at nine DOE sites that provided substantial variety in terms of geographic location, types of environmental management activities undertaken, the current life-cycle stage of those EM efforts, and the public participation mechanisms utilized. Approximately 12 to 15 oral interviews were conducted at each site, and each respondent also was asked to complete a written survey. Those interviewed included: non-regulatory state and local government officials; project managers and public participation staff for DOE and its management and operations contractors; non-government groups concerned with environmental protection, public safety, and health issues; federal and state environmental regulators; business organizations; civic groups; and other interested parties. While this study examined only those public participation programs sponsored by DOE, the resulting findings also have applicability to the public involvement efforts sponsored by many other public and private sector organizations

  9. Mission Operations Directorate - Success Legacy of the Space Shuttle Program (Overview of the Evolution and Success Stories from MOD During the Space Shuttle program)

    Science.gov (United States)

    Azbell, Jim A.

    2011-01-01

    In support of the Space Shuttle Program, as well as NASA's other human space flight programs, the Mission Operations Directorate (MOD) at the Johnson Space Center has become the world leader in human spaceflight operations. From the earliest programs - Mercury, Gemini, Apollo - through Skylab, Shuttle, ISS, and our Exploration initiatives, MOD and its predecessors have pioneered ops concepts and emphasized a history of mission leadership which has added value, maximized mission success, and built on continual improvement of the capabilities to become more efficient and effective. This paper provides specific examples that illustrate how MOD's focus on building and contributing value with diverse teams has been key to their successes both with the US space industry and the broader international community. This paper will discuss specific examples for the Plan, Train, Fly, and Facilities aspects within MOD. This paper also provides a discussion of the joint civil servant/contractor environment and the relative badge-less society within MOD. Several Shuttle mission related examples have also been included that encompass all of the aforementioned MOD elements and attributes, and are used to show significant MOD successes within the Shuttle Program. These examples include the STS-49 Intelsat recovery and repair, the (post-Columbia accident) TPS inspection process and the associated R-Bar Pitch Maneuver for ISS missions, and the STS-400 rescue mission preparation efforts for the Hubble Space Telescope repair mission. Since their beginning, MOD has consistently demonstrated their ability to evolve and respond to an ever changing environment, effectively prepare for the expected and successfully respond to the unexpected, and develop leaders, expertise, and a culture that has led to mission and Program success.

  10. Overview of the U.S. Department of Energy/National Renewable Energy Laboratory avian research program

    International Nuclear Information System (INIS)

    Sinclair, K.C.; Morrison, M.L.

    1997-06-01

    As wind energy use continues to expand, concern over the possible impacts of wind farms on birds continues to be an issue. The concern includes two primary areas: the effect of avian mortality on bird populations, and possible litigation over the killing of even one bird if it is protected by the Migratory Bird Treaty Act or the Endangered Species Act or both. In order to address these concerns, the US Department of Energy (DOE) and the National Renewable Energy Laboratory (NREL), working collaboratively with all stakeholders including utilities, environmental groups, consumer advocates, utility regulators, government officials, and the wind industry, has an active avian-wind power research program. DOE/NREL is conducting and sponsoring research with the expectation of developing solutions to educe or avoid avian mortality due to wind energy development throughout the US. This paper outlines the DOE/NREL approach and summarizes completed, current, and planned projects

  11. An overview of course offered by the USA, UK and France to support Nuclear Power Program (NPP)

    International Nuclear Information System (INIS)

    Sheriffah Noor Khamseah Al-Idid Syed Ahmad Idid

    2012-01-01

    In her presentation, speaker address a topic on nuclear education that offered by USA, UK and France to support nuclear power program. Her presentation actually assist students that are willing to explore several courses related to nuclear energy and its application. The speaker also explained briefly the impact of major nuclear accidents such as Fukushima that can influence the participation of students to study in these fields. She also outlines several nuclear stake holders and also some activities to support nuclear application such as planning, research, engineering, environmental impact assessment and others. She also explain in detail the needs to develop human capital especially for this field. At the end of her lectures, she tried to suggest several recommendations so that the audients can use in order to review their own strategies and planning for future training and studies. (author)

  12. Overview of the U.S. Department of Energy/National Renewable Energy Laboratory avian research program

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, K.C. [National Renewable Energy Lab., Golden, CO (United States); Morrison, M.L. [California State Univ., Sacramento, CA (United States). Dept. of Biological Sciences

    1997-06-01

    As wind energy use continues to expand, concern over the possible impacts of wind farms on birds continues to be an issue. The concern includes two primary areas: the effect of avian mortality on bird populations, and possible litigation over the killing of even one bird if it is protected by the Migratory Bird Treaty Act or the Endangered Species Act or both. In order to address these concerns, the US Department of Energy (DOE) and the National Renewable Energy Laboratory (NREL), working collaboratively with all stakeholders including utilities, environmental groups, consumer advocates, utility regulators, government officials, and the wind industry, has an active avian-wind power research program. DOE/NREL is conducting and sponsoring research with the expectation of developing solutions to educe or avoid avian mortality due to wind energy development throughout the US. This paper outlines the DOE/NREL approach and summarizes completed, current, and planned projects.

  13. Overview of the nuclear fuel resources – seawater uranium recovery program sponsored by the U.S. Department of Energy

    International Nuclear Information System (INIS)

    Kung, S.

    2014-01-01

    For nuclear energy to remain a sustainable energy source, there must be assurance that an economically viable supply of nuclear fuel is available. One major goal of the Fuel Cycle Technology Research and Development (R&D) Program in the United States Department of Energy (DOE), Office of Nuclear Energy (NE) is to develop sustainable fuel cycles options. The development of technology to recover uranium from seawater has the potential to fulfill this program goal. Seawater uranium recovery technology is identified in the U.S. DOE NE Roadmap as an area most appropriate for federal involvement to support long-term, “game-changing” approach. Seawater contains more than 4 billion metric tons of dissolved uranium. This unconventional uranium resource, combined with a suitable extraction cost, can potentially meet the uranium demands for centuries to come. The challenge, however, is the low concentration of uranium in seawater – approximately 3.3 ppb. A multidisciplinary team from the U.S. national laboratories, universities, and research institutes has been assembled to address this challenge. Polymeric adsorbents materials containing amidoxime ligands, developed at the Oak Ridge National Laboratory (ORNL), have demonstrated great promise for the extraction of uranium from seawater. These ORNL adsorbents showed adsorption capacities for the extraction of uranium from seawater that exceed 3 mg U/g adsorbent in testing at the Pacific Northwest National Laboratory Marine Sciences Laboratory. A key component of this novel technology lies in the unique high surface-area polyethylene fibers that considerably increase the surface area and thus the grafting yield of functional groups without compromising its mechanical properties. In addition, high surface area nanomaterial adsorbents are under development at ORNL with the goal of increasing uranium adsorption capacity by taking advantage of the high surface areas and tunable porosity of carbon-based nanomaterials

  14. Green power programs in Canada : 2003 : overview of Government green power policies, utility green power implementation initiatives, green power and certificate marketing programs, and their benefits

    International Nuclear Information System (INIS)

    Whitmore, J.; Bramley, M.; Holmes, R.

    2004-09-01

    Green power is defined as electricity produced from renewable sources, and whose production has low adverse impacts on the environment, human health and communities. Green power has near-zero greenhouse gas (GHG) emissions and includes sources such as wind, hydro, and solar power. It offers several environmental benefits, as well as the enhancement of energy security, regional development, economic diversification and the creation of skilled jobs. There are four categories of programs related to green power development in Canada: government green power policies, utility green power development programs, green power marketing initiatives, and green power certificate marketing initiatives. Most of the activities in Canada associated with these four categories in 2003 were discussed in this report. However, difficulties with quantification prevented the inclusion of some green power activities such as (1) the generation of green power not certified or identified by the generator as green power, (2) industry or residential self-generation, (3) net metering, and (4) small government programs. Green power generation facilities in 2003 totaled 775 MW of capacity compared to 539 MW in 2002. Hydro capacity represented 41 per cent, followed by wind capacity at 40 per cent and wood waste at 17 per cent. Most of the green power generation facilities in 2003 were located in Alberta, followed by British Columbia, Ontario and Quebec. 230 refs., 8 tabs., 1 fig

  15. The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2.

    Science.gov (United States)

    Bugga, Lakshmi; McDaniel, Ivy E; Engie, Liana; Armstrong, Jennifer A

    2013-01-01

    CHD1 is a conserved chromatin remodeling factor that localizes to active genes and functions in nucleosome assembly and positioning as well as histone turnover. Mouse CHD1 is required for the maintenance of stem cell pluripotency while human CHD1 may function as a tumor suppressor. To investigate the action of CHD1 on higher order chromatin structure in differentiated cells, we examined the consequences of loss of CHD1 and over-expression of CHD1 on polytene chromosomes from salivary glands of third instar Drosophila melanogaster larvae. We observed that chromosome structure is sensitive to the amount of this remodeler. Loss of CHD1 resulted in alterations of chromosome structure and an increase in the heterochromatin protein HP1a, while over-expression of CHD1 disrupted higher order chromatin structure and caused a decrease in levels of HP1a. Over-expression of an ATPase inactive form of CHD1 did not result in severe chromosomal defects, suggesting that the ATPase activity is required for this in vivo phenotype. Interestingly, changes in CHD1 protein levels did not correlate with changes in the levels of the euchromatin mark H3K4me3 or elongating RNA Polymerase II. Thus, while CHD1 is localized to transcriptionally active regions of the genome, it can function to alter the levels of HP1a, perhaps through changes in methylation of H3K9.

  16. The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2.

    Directory of Open Access Journals (Sweden)

    Lakshmi Bugga

    Full Text Available CHD1 is a conserved chromatin remodeling factor that localizes to active genes and functions in nucleosome assembly and positioning as well as histone turnover. Mouse CHD1 is required for the maintenance of stem cell pluripotency while human CHD1 may function as a tumor suppressor. To investigate the action of CHD1 on higher order chromatin structure in differentiated cells, we examined the consequences of loss of CHD1 and over-expression of CHD1 on polytene chromosomes from salivary glands of third instar Drosophila melanogaster larvae. We observed that chromosome structure is sensitive to the amount of this remodeler. Loss of CHD1 resulted in alterations of chromosome structure and an increase in the heterochromatin protein HP1a, while over-expression of CHD1 disrupted higher order chromatin structure and caused a decrease in levels of HP1a. Over-expression of an ATPase inactive form of CHD1 did not result in severe chromosomal defects, suggesting that the ATPase activity is required for this in vivo phenotype. Interestingly, changes in CHD1 protein levels did not correlate with changes in the levels of the euchromatin mark H3K4me3 or elongating RNA Polymerase II. Thus, while CHD1 is localized to transcriptionally active regions of the genome, it can function to alter the levels of HP1a, perhaps through changes in methylation of H3K9.

  17. MINA controls proliferation and tumorigenesis of glioblastoma by epigenetically regulating cyclins and CDKs via H3K9me3 demethylation.

    Science.gov (United States)

    Huang, M-Y; Xuan, F; Liu, W; Cui, H-J

    2017-01-19

    It is generally known that histone demethylases regulate gene transcription by altering the methylate status on histones, but their roles in cancers and the underlying molecular mechanisms still remain unclear. MYC-induced nuclear antigen (MINA) is reported to be a histone demethylase and highly expressed in many cancers. Here, for the first time, we show that MINA is involved in glioblastoma carcinogenesis and reveal the probable mechanisms of it in cell-cycle control. Kaplan-Meier analysis of progression-free survival showed that high MINA expression was strongly correlated with poor outcome and advancing tumor stage. MINA knockdown significantly repressed the cell proliferation and tumorigenesis abilities of glioblastoma cells in vitro and in vivo that were rescued by overexpressing the full-length MINA afterwards. Microarray analysis after knockdown of MINA revealed that MINA probably regulated glioblastoma carcinogenesis through the predominant cell-cycle pathways. Further investigation showed that MINA deficiency led to a cell-cycle arrest in G1 and G2 phases. And among the downstream genes, we found that cyclins and cyclin-dependent kinases were directly activated by MINA via the demethylation of H3K9me3.

  18. Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution

    Directory of Open Access Journals (Sweden)

    Emma Rey-Jurado

    2018-01-01

    Full Text Available Vaccines have significantly reduced the detrimental effects of numerous human infectious diseases worldwide, helped to reduce drastically child mortality rates and even achieved eradication of major pathogens, such as smallpox. These achievements have been possible due to a dedicated effort for vaccine research and development, as well as an effective transfer of these vaccines to public health care systems globally. Either public or private institutions have committed to developing and manufacturing vaccines for local or international population supply. However, current vaccine manufacturers worldwide might not be able to guarantee sufficient vaccine supplies for all nations when epidemics or pandemics events could take place. Currently, different countries produce their own vaccine supplies under Good Manufacturing Practices, which include the USA, Canada, China, India, some nations in Europe and South America, such as Germany, the Netherlands, Italy, France, Argentina, and Brazil, respectively. Here, we discuss some of the vaccine programs and manufacturing capacities, comparing the current models of vaccine management between industrialized and developing countries. Because local vaccine production undoubtedly provides significant benefits for the respective population, the manufacture capacity of these prophylactic products should be included in every country as a matter of national safety.

  19. Brief overview of the long-lived radionuclide separation processes developed in France in connection with the SPIN program

    International Nuclear Information System (INIS)

    Madic, C.; Bourges, J.; Dozol, J.F.

    1995-01-01

    To reduce the long-term potential hazards associated with the management of nuclear wastes generated by nuclear fuel reprocessing, one alternative is the transmutation of long-lived radionuclides into short-lived radionuclides by nuclear means (P ampersand T strategy). In this context, according to the law passed by the French Parliament on 30 December 1991, the CEA launched the SPIN program for the design of long-lived radionuclide separation and nuclear incineration processes. The research in progress to define separation processes focused mainly on the minor actinides (neptunium, americium and curium) and some fission products, like cesium and technetium. To separate these long-lived radionuclides, two strategies were developed. The first involves research on new operating conditions for improving the PUREX fuel reprocessing technology. This approach concerns the elements neptunium and technetium (iodine and zirconium can also be considered). The second strategy involves the design of new processes; DIAMEX for the co-extraction of minor actinides from the high-level liquid waste leaving the PUREX process, An(III)/Ln(III) separation using tripyridyltriazine derivatives or picolinamide extracting agents; SESAME for the selective separation of americium after its oxidation to Am(IV) or Am(VI) in the presence of a heteropolytungstate ligand, and Cs extraction using a new class of extracting agents, calixarenes, which exhibit exceptional Cs separation properties, especially in the presence of sodium ion. This lecture focuses on the latest achievements in these research areas

  20. An Overview of Turkish Healthcare System after Health Transformation Program: Main Successes, Performance Assessment, Further Challenges, and Policy Options

    Directory of Open Access Journals (Sweden)

    Kadir GÜRSOY

    2015-02-01

    Full Text Available Turkish healthcare system has been stated to show significant improvements regarding wider access to healthcare facilities, and the quality and efficiency through the introduction of Health Transformation Program launched in 2003. While the old system relied on differing provisions and financing and lacked behind many developed nations in terms of health outcomes, the new system achieved nearly universal coverage and many health outcomes enhanced significantly. Health expenditures rose to 5.4% of GDP in 2013 from 4.8% in 1998. Furthermore, Turkey provided both better financial protection for the poor against high health expenditures, and equity in access to health care across the population. However, Turkey still faces new challenges to catch other developed countries to have better health and further improve financial sustainability. To reach these targets, Turkey needs to further implement new policy options for reform such as combating informal economy, allocating more on health resources, designing incentive- based payment methods, adopting gate keeping system and referral chain, developing capacity to deploy health technology assessments in reimbursement decisions, and ensuring the hospital autonomy.

  1. Overview of the SMAP Applications and the SMAP Early Adopters Program - NASA's First Mission-Directed Outreach Effort

    Science.gov (United States)

    Escobar, V. M.; Delgado Arias, S.; Nearing, G.; Entekhabi, D.; Njoku, E.; Yueh, S.; Doorn, B.; Reichle, R.

    2016-01-01

    Satellite data provide global observations of many of the earths system processes and features. These data are valuable for developing scientific products that increase our understanding of how the earths systems are integrated. The water, energy and carbon cycle exchanges between the land and atmosphere are linked by soil moisture. NASAs Soil Moisture Active Passive (SMAP) mission provides soil moisture and freeze thaw measurements from space and allows scientists to link the water energy and carbon cycles. In order for SMAP data to be best integrated into decision support systems, the mission has engaged with the stakeholder community since 2009 and has attempted to scale the utility of the data to the thematic societal impacts of the satellite product applications. The SMAP Mission, which launched on January 31, 2015, has actively grown an Early Adopter (EA) community as part of its applications effort and worked with these EAs to demonstrate a scaled thematic impact of SMAP data product in societally relevant decision support applications. The SMAP mission provides global observations of the Earths surface soil moisture, providing high accuracy, resolution and continuous global coverage. Through the Early Adopters Program, the SMAP Applications Team will spend the next 2 years after launch documenting and evaluating the use of SMAP science products in applications related to weather forecasting, drought, agriculture productivity, floods, human health and national security.

  2. Brief overview of the long-lived radionuclide separation processes developed in france in connection with the spin program

    Science.gov (United States)

    Madic, Charles; Bourges, Jacques; Dozol, Jean-François

    1995-09-01

    To reduce the long-term potential hazards associated with the management of nuclear wastes generated by nuclear fuel reprocessing, one alternative is the transmutation of long-lived radionuclides into short-lived radionuclides by nuclear means (P & T strategy). In this context, according to the law passed by the French Parliament on 30 December 1991, the CEA launched the SPIN program for the design of long-lived radionuclide separation and nuclear incineration processes. The research in progress to define separation processes focused mainly on the minor actinides (neptunium, americium and curium) and some fission products, like cesium and technetium. To separate these long-lived radionuclides, two strategies were developed. The first involves research on new operating conditions for improving the PUREX fuel reprocessing technology. This approach concerns the elements neptunium and technetium (iodine and zirconium can also be considered). The second strategy involves the design of new processes; DIAMEX for the co-extraction of minor actinides from the high-level liquid waste leaving the PUREX process, An(III)/Ln(III) separation using tripyridyltriazine derivatives or picolinamide extracting agents; SESAME for the selective separation of americium after its oxidation to Am(IV) or Am(VI) in the presence of a heteropolytungstate ligand, and Cs extraction using a new class of extracting agents, calixarenes, which exhibit exceptional Cs separation properties, especially in the presence of sodium ion. This lecture focuses on the latest achievements in these research areas.

  3. Brief overview of the long-lived radionuclide separation processes developed in France in connection with the SPIN program

    Energy Technology Data Exchange (ETDEWEB)

    Madic, C.; Bourges, J. [DRDD, Fontenay-aux-Roses (France); Dozol, J.F. [DESD, Cadarache (France)

    1995-10-01

    To reduce the long-term potential hazards associated with the management of nuclear wastes generated by nuclear fuel reprocessing, one alternative is the transmutation of long-lived radionuclides into short-lived radionuclides by nuclear means (P & T strategy). In this context, according to the law passed by the French Parliament on 30 December 1991, the CEA launched the SPIN program for the design of long-lived radionuclide separation and nuclear incineration processes. The research in progress to define separation processes focused mainly on the minor actinides (neptunium, americium and curium) and some fission products, like cesium and technetium. To separate these long-lived radionuclides, two strategies were developed. The first involves research on new operating conditions for improving the PUREX fuel reprocessing technology. This approach concerns the elements neptunium and technetium (iodine and zirconium can also be considered). The second strategy involves the design of new processes; DIAMEX for the co-extraction of minor actinides from the high-level liquid waste leaving the PUREX process, An(III)/Ln(III) separation using tripyridyltriazine derivatives or picolinamide extracting agents; SESAME for the selective separation of americium after its oxidation to Am(IV) or Am(VI) in the presence of a heteropolytungstate ligand, and Cs extraction using a new class of extracting agents, calixarenes, which exhibit exceptional Cs separation properties, especially in the presence of sodium ion. This lecture focuses on the latest achievements in these research areas.

  4. Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution.

    Science.gov (United States)

    Rey-Jurado, Emma; Tapia, Felipe; Muñoz-Durango, Natalia; Lay, Margarita K; Carreño, Leandro J; Riedel, Claudia A; Bueno, Susan M; Genzel, Yvonne; Kalergis, Alexis M

    2018-01-01

    Vaccines have significantly reduced the detrimental effects of numerous human infectious diseases worldwide, helped to reduce drastically child mortality rates and even achieved eradication of major pathogens, such as smallpox. These achievements have been possible due to a dedicated effort for vaccine research and development, as well as an effective transfer of these vaccines to public health care systems globally. Either public or private institutions have committed to developing and manufacturing vaccines for local or international population supply. However, current vaccine manufacturers worldwide might not be able to guarantee sufficient vaccine supplies for all nations when epidemics or pandemics events could take place. Currently, different countries produce their own vaccine supplies under Good Manufacturing Practices, which include the USA, Canada, China, India, some nations in Europe and South America, such as Germany, the Netherlands, Italy, France, Argentina, and Brazil, respectively. Here, we discuss some of the vaccine programs and manufacturing capacities, comparing the current models of vaccine management between industrialized and developing countries. Because local vaccine production undoubtedly provides significant benefits for the respective population, the manufacture capacity of these prophylactic products should be included in every country as a matter of national safety.

  5. Overview of U.S. DOE's Natural Gas-to-Liquids RD and D program and commercialization strategy

    International Nuclear Information System (INIS)

    Venkataraman, V.K.; Guthrie, H.D.; Avellanet, R.A.; Driscoll, D.J.

    1998-01-01

    Natural gas, which is comprised mostly of methane, is one of our most abundant natural resources, both in the U.S. and world wide. In the United States alone, recoverable natural gas resources are several times its current estimate of reserves, 166 trillion cubic feet (TCF). Unfortunately, many of these resources are located offshore or in remote areas. High transportation costs, or complete lack of any transportation mechanism, prohibits extensive use of this 'stranded' natural resource. To overcome this limitation, the U.S. Department of Energy's (DOE) Federal Energy Technology Center (FETC) has developed a highly diversified gas-to-liquids research program to evaluate, promote and develop processes that convert natural gas into higher value products (i.e., liquid fuels) which will offset the high transportation costs and allow use of this untapped, environmentally friendly resource. By advancing technologies to convert unmarketable gas resources into valuable products, cooperative efforts between DOE and industry could yield the following benefits by 20 10: (1) Our shortfall in domestic production of oil will be reduced by 200,000 to 500,000 barrels per day of high quality transportation fuel made from Alaska's North Slope gas resources; (2) Advanced gas-to-liquids conversion technology that yields ultra clean burning diesel fuels that meet the most stringent emissions requirements, at costs competitive with those of comparable fuels made from crude oils, will be utilized; and (3) Small-scale gas-to-liquids technology for both natural gas liquefaction and chemical conversion to higher hydrocarbon liquids will provide an economic and environmentally sound option for utilization of the associated gas of remote offshore oil reservoirs, and also for onshore gas reservoirs without pipeline access. In summary, development of efficient gas conversion technologies will enhance U.S. energy security, reduce dependence on oil imports and strengthen the economic

  6. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14.

    Science.gov (United States)

    Frouco, Gonçalo; Freitas, Ferdinando B; Martins, Carlos; Ferreira, Fernando

    2017-10-15

    African swine fever virus (ASFV) causes a highly lethal disease in swine for which neither a vaccine nor treatment are available. Recently, a new class of drugs that inhibit histone deacetylases enzymes (HDACs) has received an increasing interest as antiviral agents. Considering studies by others showing that valproic acid, an HDAC inhibitor (HDACi), blocks the replication of enveloped viruses and that ASFV regulates the epigenetic status of the host cell by promoting heterochromatinization and recruitment of class I HDACs to viral cytoplasmic factories, the antiviral activity of four HDACi against ASFV was evaluated in this study. Results showed that the sodium phenylbutyrate fully abrogates the ASFV replication, whereas the valproic acid leads to a significant reduction of viral progeny at 48h post-infection (-73.9%, p=0.046), as the two pan-HDAC inhibitors tested (Trichostatin A: -82.2%, p=0.043; Vorinostat: 73.9%, p=0.043). Further evaluation showed that protective effects of NaPB are dose-dependent, interfering with the expression of late viral genes and reversing the ASFV-induced histone H3 lysine 9 and 14 (H3K9K14) hypoacetylation status, compatible to an open chromatin state and possibly enabling the expression of host genes non-beneficial to infection progression. Additionally, a synergic antiviral effect was detected when NaPB is combined with an ASFV-topoisomerase II poison (Enrofloxacin). Altogether, our results strongly suggest that cellular HDACs are involved in the establishment of ASFV infection and emphasize that further in vivo studies are needed to better understand the antiviral activity of HDAC inhibitors. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Identification and Characterization of the Spodoptera Su(var) 3-9 Histone H3K9 trimethyltransferase and Its Effect in AcMNPV Infection

    Science.gov (United States)

    Li, Binbin; Li, Sisi; Yin, Juan; Zhong, Jiang

    2013-01-01

    Histone H3-lysine9 (H3K9) trimethyltransferase gene Su(var) 3-9 was cloned and identified in three Spodoptera insects, Spodoptera frugiperda ( S . frugiperda ), S . exigua and S . litura . Sequence analysis showed that Spodoptera Su(var) 3-9 is highly conserved evolutionarily. Su(var) 3-9 protein was found to be localized in the nucleus in Sf9 cells, and interact with histone H3, and the heterochromatin protein 1a (HP1a) and HP1b. A dose-dependent enzymatic activity was found at both 27 °C and 37 °C in vitro, with higher activity at 27 °C. Addition of specific inhibitor chaetocin resulted in decreased histone methylation level and host chromatin relaxation. In contrast, overexpression of Su(var) 3-9 caused increased histone methylation level and cellular genome compaction. In AcMNV-infected Sf9 cells, the transcription of Su(var) 3-9 increased at late time of infection, although the mRNA levels of most cellular genes decreased. Pre-treatment of Sf9 cells with chaetocin speeded up viral DNA replication, and increased the transcription level of a variety of virus genes, whereas in Sf9 cells pre-transformed with Su(var) 3-9 expression vector, viral DNA replication slow down slightly. These findings suggest that Su(var) 3-9 might participate in the viral genes expression an genome replication repression during AcMNPV infection. It provided a new insight for the understanding virus–host interaction mechanism. PMID:23894480

  8. Identification and characterization of the Spodoptera Su(var) 3-9 histone H3K9 trimethyltransferase and its effect in AcMNPV infection.

    Science.gov (United States)

    Li, Binbin; Li, Sisi; Yin, Juan; Zhong, Jiang

    2013-01-01

    Histone H3-lysine(9) (H3K9) trimethyltransferase gene Su(var) 3-9 was cloned and identified in three Spodoptera insects, Spodopterafrugiperda (S. frugiperda), S. exigua and S. litura. Sequence analysis showed that Spodoptera Su(var) 3-9 is highly conserved evolutionarily. Su(var) 3-9 protein was found to be localized in the nucleus in Sf9 cells, and interact with histone H3, and the heterochromatin protein 1a (HP1a) and HP1b. A dose-dependent enzymatic activity was found at both 27 °C and 37 °C in vitro, with higher activity at 27 °C. Addition of specific inhibitor chaetocin resulted in decreased histone methylation level and host chromatin relaxation. In contrast, overexpression of Su(var) 3-9 caused increased histone methylation level and cellular genome compaction. In AcMNV-infected Sf9 cells, the transcription of Su(var) 3-9 increased at late time of infection, although the mRNA levels of most cellular genes decreased. Pre-treatment of Sf9 cells with chaetocin speeded up viral DNA replication, and increased the transcription level of a variety of virus genes, whereas in Sf9 cells pre-transformed with Su(var) 3-9 expression vector, viral DNA replication slow down slightly. These findings suggest that Su(var) 3-9 might participate in the viral genes expression an genome replication repression during AcMNPV infection. It provided a new insight for the understanding virus-host interaction mechanism.

  9. PHOBOS Overview

    Science.gov (United States)

    Hofman, David J.; Phobos Collaboration; Bbback; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Chai, Z.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Hauer, M.; Heintzelman, G. A.; Henderson, C.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Wenger, E.; Wolfs, F. L. H.; Wosiek, B.; Kwoźniak; Wysłouch, B.

    2006-11-01

    A brief overview of the current results and conclusions from the PHOBOS experiment at the Relativistic Heavy Ion Collider (RHIC) is given. No evidence is found for non-monotonic behavior of observables measured by PHOBOS in the RHIC energy region. Convincing evidence is found that we have created a state of matter with high energy-density, that is nearly net-baryon free and is strongly interacting. The data are found to exhibit "simple" scaling behaviors, which include extended longitudinal scaling and scaling with the number of participating nucleons. The Au+Au collision charged particle data also exhibit a remarkable factorization of collision energy and geometry.

  10. Experimental overview

    International Nuclear Information System (INIS)

    Nagamiya, Shoji

    1992-01-01

    Five years ago the first heavy-ion beams were accelerated at both the BNL-AGS and the CERN-SPS. This conference is the 5th anniversary in the experimental field. Currently, four experimental groups (E802/E859, E810, E814, E858) are taking data at BNL and eight groups (NA34-3, NA44, NA45, NA35, NA36, NA38, WA80/WA93, WA85) at CERN. Au and Pb beams are about to come, and a lot of activities are going on for RHIC and LHC. The purpose of this talk is to overview where we are, in particular, by looking at the past data. In this talk, the data of proton rapidity distributions are reviewed first to study nuclear transparency, then, the data of energy spectra and slopes, HBT and anti d production are discussed in connection with the evolution of the collision. Third, the data of strangeness production are described. Finally, the status of J/ψ and that of soft photons and electron pairs are briefly overviewed. (orig.)

  11. KEY COMPARISON: Final report on bilateral comparison CCEM.RF-K9.1: Thermal noise standards at 12.4 GHz, 13.5 GHz, 15 GHz and 17.5 GHz

    Science.gov (United States)

    Allal, Djamel

    2009-01-01

    A bilateral comparison subsequent to key comparison CCEM.RF-K9 was decided between VNIIFTRI and PTB. It was registered into the BIPM KCDB under the identifier CCEM.RF-K9.1. The results of this comparison were gathered by the pilot laboratory of comparison CCEM.RF-K9, the LNE, and a very good agreement was found between the two participants. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  12. The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail ‘histone code’ and Riz1 tumor suppressor function

    Science.gov (United States)

    Congdon, Lauren M.; Sims, Jennifer K.; Tuzon, Creighton T.; Rice, Judd C.

    2014-01-01

    PR-Set7/Set8/KMT5a is the sole histone H4 lysine 20 monomethyltransferase (H4K20me1) in metazoans and is essential for proper cell division and genomic stability. We unexpectedly discovered that normal cellular levels of monomethylated histone H3 lysine 9 (H3K9me1) were also dependent on PR-Set7, but independent of its catalytic activity. This observation suggested that PR-Set7 interacts with an H3K9 monomethyltransferase to establish the previously reported H4K20me1-H3K9me1 trans-tail ‘histone code’. Here we show that PR-Set7 specifically and directly binds the C-terminus of the Riz1/PRDM2/KMT8 tumor suppressor and demonstrate that the N-terminal PR/SET domain of Riz1 preferentially monomethylates H3K9. The PR-Set7 binding domain was required for Riz1 nuclear localization and maintenance of the H4K20me1-H3K9me1 trans-tail ‘histone code’. Although Riz1 can function as a repressor, Riz1/H3K9me1 was dispensable for the repression of genes regulated by PR-Set7/H4K20me1. Frameshift mutations resulting in a truncated Riz1 incapable of binding PR-Set7 occur frequently in various aggressive cancers. In these cancer cells, expression of wild-type Riz1 restored tumor suppression by decreasing proliferation and increasing apoptosis. These phenotypes were not observed in cells expressing either the Riz1 PR/SET domain or PR-Set7 binding domain indicating that Riz1 methyltransferase activity and PR-Set7 binding domain are both essential for Riz1 tumor suppressor function. PMID:24423864

  13. Ostomy Home Skills Program

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  14. GEOTAB. Overview

    International Nuclear Information System (INIS)

    Eriksson, E.; Stark, T.; Johansson, B.; Magnusson, S.; Gerlach, M.; Sehlstedt, S.; Nilsson, A.C.

    1992-01-01

    Since 1977 Swedish Nuclear Fuel and Waste Managements Co., SKB has been performing a research and development program for the final disposal of spent nuclear fuel. One aim of this program is to gain knowledge of different bedrock properties. Measurements for the characterization of geological, geophysical, hydrogeological and hydrochemical conditions are performed in specific site investigations as well as for geoscientific projects. Large volumes of data have been produced since the start of the program, in the form of both raw data and results. During (the course of) the research program this data has been stored in various formats by different institutions and companies performing the investigations. It was therefore decided that all data from the research and development program should be stored in a single database. The database, called Geotab, is a relational database, based on a database handling system from Mimer Information Systems. The application program, also called GEOTAB, was developed by Ergodata. This manual provides a description of the basics of the database and application programs used in connection with GEOTAB. It is intended as an introduction for new and regular users. The database is a mix of information organized so that storage, retrieval and modification of the data is as efficient as possible. GEOTAB is built around a relational database model. (au)

  15. Genome-wide ChIP-seq mapping and analysis of butyrate-induced H3K9 and H3K27 acetylation and epigenomic landscape alteration in bovine cells

    Science.gov (United States)

    Utilizing next-generation sequencing technology, combined with ChIP (Chromatin Immunoprecipitation) technology, we analyzed histone modification (acetylation) induced by butyrate and the large-scale mapping of the epigenomic landscape of normal histone H3 and acetylated histone H3K9 and H3K27. To d...

  16. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast

    Science.gov (United States)

    Yamada, Shintaro; Ohta, Kunihiro; Yamada, Takatomi

    2013-01-01

    Histone modifications are associated with meiotic recombination hotspots, discrete sites with augmented recombination frequency. For example, trimethylation of histone H3 lysine4 (H3K4me3) marks most hotspots in budding yeast and mouse. Modified histones are known to regulate meiotic recombination partly by promoting DNA double-strand break (DSB) formation at hotspots, but the role and precise landscape of involved modifications remain unclear. Here, we studied hotspot-associated modifications in fission yeast and found general features: acetylation of H3 lysine9 (H3K9ac) is elevated, and H3K4me3 is not significantly enriched. Mutating H3K9 to non-acetylatable alanine mildly reduced levels of the DSB-inducing protein Rec12 (the fission yeast homologue of Spo11) and DSB at hotspots, indicating that H3K9ac may be involved in DSB formation by enhancing the interaction between Rec12 and hotspots. In addition, we found that the lack of the H3K4 methyltransferase Set1 generally increased Rec12 binding to chromatin but partially reduced DSB formation at some loci, suggesting that Set1 is also involved in DSB formation. These results suggest that meiotic DSB formation is redundantly regulated by multiple chromatin-related factors including H3K9ac and Set1 in fission yeast. PMID:23382177

  17. RETRAN overview

    International Nuclear Information System (INIS)

    Agee, L.J.

    1985-01-01

    The RETRAN code has become the industry standard with respect to NSSS transient analysis. The objective of this paper is to present an overview of important RETRAN-related events since the second International meeting in April of 1982. This paper is divided into three parts. The first part addresses the current status of the code with emphasis on the design review of RETRAN-02 MOD002 and the goal of RETRAN-02 in the Reactor Analysis Support Package (RASP). These activities are being undertaken to simplify the use of RETRAN for safety analysis and reload application which may be part of an NRC submittal. The second part of the paper describes significant applications of RETRAN. In the analysis section, special emphasis is placed on validation analyses which compare the code to actual plant data or experimental facilities. The third section briefly describes the pre-release version of RETRAN and the developmental goals for the next version of RETRAN. One major limitation of all state-of-the-art thermal-hydraulic codes is the determination of the structure of the fluid. A brief description of research needs in this are indicated

  18. Weapons engineering tritium facility overview

    Energy Technology Data Exchange (ETDEWEB)

    Najera, Larry [Los Alamos National Laboratory

    2011-01-20

    Materials provide an overview of the Weapons Engineering Tritium Facility (WETF) as introductory material for January 2011 visit to SRS. Purpose of the visit is to discuss Safety Basis, Conduct of Engineering, and Conduct of Operations. WETF general description and general GTS program capabilities are presented in an unclassified format.

  19. An Overview. High Risk Series.

    Science.gov (United States)

    General Accounting Office, Washington, DC.

    This report provides an overview of efforts undertaken by the U.S. General Accounting Office (GAO) in 1990 to review and report on federal program areas its work identified as high risk because of vulnerabilities to waste, fraud, abuse, and mismanagement. It reviews the current status of efforts to address these concerns. The six categories of…

  20. Radiation Detection Overview for Nuclear Emergency Response

    Energy Technology Data Exchange (ETDEWEB)

    Myers, Steven Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-11-16

    This presentation discusses the fundamentals of gamma and neutron detection; presents an overview of the DOE Triage and JTOT Programs, gamma, and neutron signatures in select measurements; and offers a detector demonstration.

  1. 24 CFR 982.501 - Overview.

    Science.gov (United States)

    2010-04-01

    ... TENANT BASED ASSISTANCE: HOUSING CHOICE VOUCHER PROGRAM Rent and Housing Assistance Payment § 982.501 Overview. (a) This subpart describes program requirements concerning the housing assistance payment and rent to owner. These requirements apply to the Section 8 tenant-based program. (b) There are two types...

  2. Early postnatal feed restriction reduces liver connective tissue levels and affects H3K9 acetylation state of regulated genes associated with protein metabolism in low birth weight pigs.

    Science.gov (United States)

    Nebendahl, Constance; Görs, Solvig; Albrecht, Elke; Krüger, Ricarda; Martens, Karen; Giller, Katrin; Hammon, Harald M; Rimbach, Gerald; Metges, Cornelia C

    2016-03-01

    Intrauterine growth retardation is associated with metabolic consequences in adulthood. Since our previous data indicate birth weight-dependent effects of feed restriction (R) on protein degradation processes in the liver, it should be investigated whether effects on connective tissue turnover are obvious and could be explained by global changes of histone H3K9me3 and H3K9ac states in regulated genes. For this purpose, female littermate pigs with low (U) or normal (N) birth weight were subjected to 3-week R (60% of ad libitum fed controls) with subsequent refeeding (REF) for further 5 weeks. The 3-week R-period induced a significant reduction of connective tissue area by 43% in the liver of U animals at 98 d of age, which was not found in age-matched N animals. Of note, after REF at 131 d of age, in previously feed-restricted U animals (UR), the percentage of mean connective tissue was only 53% of ad libitum fed controls (UK), indicating a persistent effect. In U animals, R induced H3K9 acetylation of regulated genes (e.g. XBP1, ERLEC1, GALNT2, PTRH2), which were inter alia associated with protein metabolism. In contrast, REF was mostly accompanied by deacetylation in U and N animals. Thus, our epigenetic data may give a first explanation for the observed birth weight-dependent differences in this connective tissue phenotype. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Photoionization study of Ne-like K9+, Ca10+, Sc11+, Ti12+, V13+, Cr14+, Mn15+, and Fe16+ ions using the screening constant by unit nuclear charge method

    International Nuclear Information System (INIS)

    Goyal, Arun; Khatri, Indu; Sow, Malick; Sakho, Ibrahima; Aggarwal, Sunny; Singh, A.K.; Mohan, Man

    2016-01-01

    Photoionization of the 2s 2 2p 6 ( 1 S 0 ) ground state of the Ne-like (Z=19–29) ions is presented in this paper. Resonance energies and total natural width of the 2s2p 6 np 1 P series of the Ne-like K 9+ , Ca 10+ , Sc 11+ , Ti 12+ , V 13+ , Cr 14+ , Mn 15+ , and Fe 16+ are reported. All the calculations are made using the Screening constant by unit nuclear charge (SCUNC) formalism. New data for Ne-like K 9+ , Sc 11+ , Ti 12+ , V 13+ , Cr 14+ , and Mn 15+ ions are tabulated. Good agreements are found with available literature data. - Highlights: • Photoionization of ground state of the Ne-like (Z=19–29) presented. • good agreements with scarce literature data. • New data for Ne-like K 9+ , Sc 11+ , Ti 12+ , V 13+ , Cr 14+ , and Mn 15+ ions. • Useful guidelines for application in laboratory, astrophysics, and plasma physics.

  4. Ostomy Home Skills Program

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    Full Text Available ... Membership Directory 2017 Annual Meeting 2016 Annual Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact Us Quality Programs Quality Programs Overview About Quality Programs ACS ...

  5. Ostomy Home Skills Program

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  6. EDM forum supplement overview.

    Science.gov (United States)

    Calonge, Ned

    2012-07-01

    The Agency for Health Research and Quality funded the Electronic Data Methods Forum (EDM Forum) to share the experiences and learnings from 11 research teams funded through three different grant programs, each of which involve the use of electronic clinical data in Comparative Effectiveness Research and Patient-Centered Outcomes Research. This overview is meant to describe the context in which the EDM forum was created and to introduce the set of papers in this supplement to Medical Care that describe the challenges and approaches to the use of electronic clinical data in the three key areas of analytic methods, clinical informatics and data governance. The participants in the EDM Forum are providing innovative approaches to generate information that can support the building of a "learning health care system." The compilation of papers presented in this supplement should serve as a resource to others working to develop the infrastructure for collecting, validating and using electronic data for research.

  7. Session Overview

    Science.gov (United States)

    Spencer, Cherrill

    2010-02-01

    High-school teachers are amongst the most important contributors to the development of the science and technology workforce of the future. Many of the more than 23,000 US high-school physics teachers are not adequately prepared to teach the subject. Only one-third of them, for example, majored in physics or physics education. Can inadequate teacher preparation be a factor in the poor performance of US students on international assessments of their achievements in science and physics? Since 1995 the Trends in International Mathematics and Science Study (TIMSS) has been administered four times to many hundreds of thousands of students in over 60 countries. TIMSS is used to measure trends in the mathematics and science knowledge and skills of fourth- and eighth-graders. The Program for International Student Assessment (PISA) has been administered three times since 2000, it focuses on 15-year-olds' capabilities in reading literacy, mathematics literacy, and science literacy. TIMSS Advanced (1995) assessed school-leaving students who have had special preparation in advanced mathematics and physics. In all these studies the US students, including the Advanced Placement physics students, scored below the international average, sometimes in the bottom third of countries! Three speakers have been invited to talk about the physics K-12 education systems in other countries, one that consistently scores at the top of the PISA (Finland) or score much higher than the USA on TIMSS ( various Northern European countries) and significantly better on recent bi-lateral comparisons (China). What can we learn from the physics teaching systems in these high-scoring countries that might be applied in the USA? There will be a panel discussion following the 3 invited talks, audience participation will be encouraged. )

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Chapter Competition Editorial Board Contact Resources in Surgical Education Newsletters Newsletters Overview Newsletters Overview ACS-AEI Consortium Quarterly ACS Chapter News Cancer Programs Brief Committee on Trauma News The Cutting Edge Philanthropy at Work ...

  9. DOE Hydrogen & Fuel Cell Overview

    Science.gov (United States)

    2011-01-13

    AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Department of Energy...Overview of Combined Heat+Power PowerElectricity Natural Gas Heat + Cooling Natural Gas or Biogas ...Fuel Cell Technologies Program eere.energy.gov Source: US DOE 10/2010 Biogas Benefits: Preliminary Analysis Stationary fuel

  10. 24 CFR 572.1 - Overview of HOPE 3.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Overview of HOPE 3. 572.1 Section... DEVELOPMENT COMMUNITY FACILITIES HOPE FOR HOMEOWNERSHIP OF SINGLE FAMILY HOMES PROGRAM (HOPE 3) General § 572.1 Overview of HOPE 3. The purpose of the HOPE for Homeownership of Single Family Homes program (HOPE...

  11. ORNL: PWR-BDHT analysis procedure, a preliminary overview

    International Nuclear Information System (INIS)

    Cliff, S.B.

    1978-01-01

    The computer programs currently used in the analysis of the ORNL-PWR Blowdown Heat Transfer Separate-Effects Program are overviewed. The current linkages and relationships among the programs are given along with general comments about the future directions of some of these programs. The overview is strictly from the computer science point of view with only minimal information concerning the engineering aspects of the analysis procedure

  12. Overview of the U.S. Nuclear Regulatory Commission collaborative research program to assess tsunami hazard for nuclear power plants on the Atlantic and Gulf Coasts

    Science.gov (United States)

    Kammerer, A.M.; ten Brink, Uri S.; Titov, V.V.

    2017-01-01

    In response to the 2004 Indian Ocean Tsunami, the United States Nuclear Regulatory Commission (US NRC) initiated a long-term research program to improve understanding of tsunami hazard levels for nuclear facilities in the United States. For this effort, the US NRC organized a collaborative research program with the United States Geological Survey (USGS) and the National Oceanic and Atmospheric Administration (NOAA) with a goal of assessing tsunami hazard on the Atlantic and Gulf Coasts of the United States. Necessarily, the US NRC research program includes both seismic- and landslide-based tsunamigenic sources in both the near and the far fields. The inclusion of tsunamigenic landslides, an important category of sources that impact tsunami hazard levels for the Atlantic and Gulf Coasts is a key difference between this program and most other tsunami hazard assessment programs. The initial phase of this work consisted of collection, interpretation, and analysis of available offshore data, with significant effort focused on characterizing offshore near-field landslides and analyzing their tsunamigenic potential and properties. In the next phase of research, additional field investigations will be conducted in key locations of interest and additional analysis will be undertaken. Simultaneously, the MOST tsunami generation and propagation model used by NOAA will first be enhanced to include landslide-based initiation mechanisms and then will be used to investigate the impact of the tsunamigenic sources identified and characterized by the USGS. The potential for probabilistic tsunami hazard assessment will also be explore in the final phases of the program.

  13. Computational Thinking in K-9 Education

    NARCIS (Netherlands)

    Mannila, Linda; Dagiene, Valentina; Demo, Barbara; Grgurina, Natasa; Mirolo, Claudio; Rolandsson, Lennart; Settle, Amber

    2014-01-01

    In this report we consider the current status of the coverage of computer science in education at the lowest levels of education in multiple countries. Our focus is on computational thinking (CT), a term meant to encompass a set of concepts and thought processes that aid in formulating problems and

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Policy Updates Selected Research Findings Quality Program Initiatives Communications to the Profession Advocacy Advocacy Overview Quality Payment Program QPP Resource Center QPP Resource Center 2018 Information 2017 Information Program Rules Surgeon Specific Registry Metabolic ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior Surgical Society ... Programs Quality Programs Overview About Quality Programs ACS Leadership in Quality ACS Leadership in Quality Setting the ...

  16. Nuclear energy research initiative, an overview of the cooperative program for the risk-informed assessment of regulatory and design requirements for future nuclear power plants

    International Nuclear Information System (INIS)

    Ritterbusch, Stanley E.

    2000-01-01

    EPRI sstudies have shown that nuclear plant capital costs will have to decrease by about 35% to 40% to be competitive with fossil-generated electricity in the Unite States. Also, the ''first concrete'' to fuel load construction schedule will have to be decreased to less than 40 months. Therefore, the U. S. Department of Energy (DOE) initiate the Nuclear Energy Research Initiative (NERI) and ABB CENP proposed a cooperative program with Sandia National Laboratory (SNL) and Duke Engineering and Services (DE and S) to begin an innovative research effort to drastically cut the cost of new nuclear power plant construction for the U. S. de-regulated market place. This program was approved by the DOE through three separate but coordinated ''cooperative agreements.'' They are the ''Risk-Informed Assessment of Regulatory and Design Requirements for Future Nuclear Power Plants'' (Risk-Informed NPP), the ''Smart Nuclear Power Plant Program'' (Smart-NPP), and ''Design, Procure, Construct, Install and Test'' (DPCIT) Program. DOE funded the three cooperative agreements at a level of $2.6 million for the first year of the program. Funding for the complete program is durrently at a level $6.9 million, however, ABB CENP and all partners anticipate that the scope of the NERI program will be increased as a result of the overall importance of NERI to the U. S. Government. The Risk-Informed NPP program, which is aimed at revising costly regularory and design requirements without reducing overall plant safety, has two basic tasks: ''development of Risk-Informed Methods'' and ''strengthening the Reliability Database.'' The overall objective of the first task is to develop a scientific, risk-informed approach for identifying and simplifying deterministic industry standards, regulatory requirements, and safety systems that do not significantly contribute to nuclear power plant reliability and safety. The second basic task is to develop a means for strengthening the reliability database

  17. Chronic Diseases Overview

    Science.gov (United States)

    ... Plan Templates All Chronic Surveillance Systems Communications Center Social Media Press Room Press Release Archives Multimedia Communication Campaigns Publications Chronic Disease Overview 2016–2017 At A ...

  18. Overview of the science activities for the 2002 Mallik gas hydrate production research well program, Mackenzie Delta, N.W.T., Canada

    Science.gov (United States)

    Dallimore, S. R.; Collett, T. S.; Uchida, T.; Weber, M.

    2003-04-01

    With the completion of scientific studies undertaken as part of the 1998 Mallik 2L-38 gas hydrate research well, an international research site was established for the study of Arctic natural gas hydrates in the Mackenzie Delta of northwestern Canada. Quantitative well log analysis and core studies reveal multiple gas hydrate layers from 890 m to 1106 m depth, exceeding 110 m in total thickness. High gas hydrate saturation values, which in some cases exceed 80% of the pore volume, establish the Mallik gas hydrate field as one of the most concentrated gas hydrate reservoirs in the world. Beginning in December 2001 and continuing to the middle of March 2002, two 1188 m deep science observation wells were drilled and instrumented and a 1166 m deep production research well program was carried out. The program participants include 8 partners; The Geological Survey of Canada (GSC), The Japan National Oil Corporation (JNOC), GeoForschungsZentrum Potsdam (GFZ), United States Geological Survey (USGS), United States Department of the Energy (USDOE), India Ministry of Petroleum and Natural Gas (MOPNG)/Gas Authority of India (GAIL) and the Chevron-BP-Burlington joint venture group. In addition the project has been accepted as part of the International Scientific Continental Drilling Program. The Geological Survey of Canada is coordinating the science program for the project and JAPEX Canada Ltd. acted as the designated operator for the fieldwork. Primary objectives of the research program are to advance fundamental geological, geophysical and geochemical studies of the Mallik gas hydrate field and to undertake advanced production testing of a concentrated gas hydrate reservoir. Full-scale field experiments in the production well monitored the physical behavior of the hydrate deposits in response to depressurization and thermal stimulation. The observation wells facilitated cross-hole tomography and vertical seismic profile experiments (before and after production) as well as

  19. Preparing for a "Next Generation" Evaluation of Independent Living Programs for Youth in Foster Care: Project Overview. OPRE Report No. 2014-71

    Science.gov (United States)

    McDaniel, Marla; Courtney, Mark E.; Pergamit, Michael R.; Lowenstein, Christopher

    2014-01-01

    Youth transitioning out of foster care and into adulthood need multiple supports to navigate the challenges they face. Over the past three decades, federal child welfare policy has significantly increased the availability of those supports. In 1999, the Chafee Foster Care Independence Program was created, increasing the amount of funds potentially…

  20. Overview of the ANL advanced LMR system thermal-hydraulic test program supporting both GE/PRISM and RI/SAFR

    International Nuclear Information System (INIS)

    Oras, J.J.; Kuzay, T.M.; Kasza, K.E.

    1988-01-01

    Descriptions of the ANL thermal-hydraulic water models of both the PRISM and SAFR reactors are presented, together with results from Phases I and II of the thermal-hydraulic test program. Phenomena discovered during these tests and modeling results are presented. Overall, these efforts demonstrate the acceptable thermal-hydraulic performance of both the PRISM and SAFR concepts

  1. Brief mental health interventions in conflict and emergency settings: an overview of four Médecins Sans Frontières - France programs.

    Science.gov (United States)

    Coldiron, Matthew E; Llosa, Augusto E; Roederer, Thomas; Casas, German; Moro, Marie-Rose

    2013-11-01

    Mental health problems, particularly anxiety and mood disorders, are prevalent in the setting of humanitarian emergencies, both natural and man-made disasters. Evidence regarding best strategies for therapeutic interventions is sparse. Médecins Sans Frontières has been providing mental health services during emergencies for over two decades, and here we compare data from four programs. In China, 564 patients were followed for an average of 7 sessions after a major earthquake. The most common diagnoses were PTSD and other anxiety disorders. Between program entry and exit, the median global assessment of functioning increased from 65 to 80. At program entry, 58% were considered moderately, markedly or severely ill; a proportion which fell to 14% at program exit. In Colombia in the setting of chronic violence, 2411 patients were followed for a median of two sessions. Anxiety disorders and major depression were the most common diagnoses, and 76% of patients were moderately or severely ill at program entry. 91% had symptomatic improvement at program exit. In Gaza, 1357 patients were followed for a median of 9 sessions; a majority was under age 15. PTSD and other anxiety disorders were the most common diagnoses, and 91% were moderately or severely ill at entry. 89% had improved symptoms at program exit. In the West Bank, the 1478 patients had similar characteristics to those enrolled in Gaza. 88% were moderately or severely ill at entry; 88% had improved at exit. It was feasible to implement brief yet effective mental health interventions in a wide variety of humanitarian contexts - post-natural disaster, during acute violent conflict and during chronic violent conflict. The most common diagnoses were PTSD, other anxiety disorders and mood disorders. The use of local specially-trained counselors who were focused on coping skills and improving functionality over a brief time period, likely contributed to the symptomatic improvement seen in a large majority of patients

  2. AVLIS documentation overview and tables of contents

    International Nuclear Information System (INIS)

    1984-01-01

    Three documents constitute the executive summary series in Data Package III: this document (Documentation Overview and Tables of Contents (E001)) plus the AVLIS Production Plant Executive Summary (E010) and the AVLIS Production Plant Overall Design Report (E020). They provide progressively greater detail on the key information and conclusions contained within the data package. The Executive Summary and Overall Design Report present summaries of each Data Package III document. They are intended to provide a global overview of AVLIS Production Plant deployment including program planning, project management, schedules, engineering design, production, operations, capital cost, and operating cost. The purpose of Overview and Tables of Contents is threefold: to briefly review AVLIS goals for Data Package III documentation, to present an overview of the contents of the data package, and to provide a useful guide to information contained in the numerous documents comprising the package

  3. Integrated Medical Model Overview

    Science.gov (United States)

    Myers, J.; Boley, L.; Foy, M.; Goodenow, D.; Griffin, D.; Keenan, A.; Kerstman, E.; Melton, S.; McGuire, K.; Saile, L.; hide

    2015-01-01

    The Integrated Medical Model (IMM) Project represents one aspect of NASA's Human Research Program (HRP) to quantitatively assess medical risks to astronauts for existing operational missions as well as missions associated with future exploration and commercial space flight ventures. The IMM takes a probabilistic approach to assessing the likelihood and specific outcomes of one hundred medical conditions within the envelope of accepted space flight standards of care over a selectable range of mission capabilities. A specially developed Integrated Medical Evidence Database (iMED) maintains evidence-based, organizational knowledge across a variety of data sources. Since becoming operational in 2011, version 3.0 of the IMM, the supporting iMED, and the expertise of the IMM project team have contributed to a wide range of decision and informational processes for the space medical and human research community. This presentation provides an overview of the IMM conceptual architecture and range of application through examples of actual space flight community questions posed to the IMM project.

  4. An overview of MEDM

    International Nuclear Information System (INIS)

    Evans, K. Jr.

    1999-01-01

    MEDM, which is derived from Motif Editor and Display Manager, is the primary graphical user interface to the EPICS control system and has also been used for other control systems. MEDM has two modes of operation, EDIT and EXECUTE. In its EDIT mode it provides the drawing tools needed to design control screens for operator interfaces. In its EXECUTE mode it manages those screens to communicate with the control system. MEDM provides a set of interface objects that falls into three main categories: (1) Monitors, such as text, meters, and plots; (2) Controllers, such as buttons, menus, and sliders; and (3) Drawing Objects, such as lines, rectangles, and images. Each of these objects has many options, allowing for the development of screens ranging from simple to quite sophisticated. MEDM has been developed over the last decade, primarily at Argonne National Laboratory, and is a large, well tested, extensively used program. It runs on most flavors of UNIX, VMS, and Windows 95/98/NT. It has been used to design thousands of control screens, such as the one shown in Fig. 1, at the Advanced Photon Source and other sites around the world. This paper presents an overview of MEDM and its features

  5. Virginia Natural Heritage Program

    Science.gov (United States)

    Heritage About Natural Heritage Overview, Mission Natural Heritage Inventory Community Ecology Program ) | Strategic Plan (PDF) | Executive Progress Report (PDF) | Code of Ethics (PDF) Your browser does not support

  6. TA-55 and Sigma Overview

    Energy Technology Data Exchange (ETDEWEB)

    Spearing, Dane Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Safeguards Science and Technology Group (NEN-1)

    2016-11-29

    These are slides from a facility overview presentation for visiting agencies to Los Alamos National Laboratory (LANL). The TA-55 Plutonium Facility (PF-4) is discussed in detail. PF-4 is a unique resource for US plutonium programs. The basic design is flexible and has adapted to changing national needs. It is a robust facility with strong safety and security implementation. It supports a variety of national programs. It will continue for many years into the future. Sigma is then discussed in detail, which handles everything from hydrogen to uranium. It has been in long term service to the Nation (nearly 60 years). It has a flexible authorization basis to handle almost the entire periodic table. It has a wide breadth of prototyping and characterization capabilities. It has integrated program and line management.

  7. NRC Waste Incidental to Reprocessing Program: Overview of Consultation and Monitoring Activities at the Idaho National Laboratory and the Savannah River Site - What We Have Learned - 12470

    Energy Technology Data Exchange (ETDEWEB)

    Suber, Gregory [Nuclear Regulatory Commission (United States)

    2012-07-01

    In 2005 the U.S. Nuclear Regulatory Commission (NRC) began to implement a new set of responsibilities under the Ronald W. Reagan National Defense Authorization Act (NDAA) of Fiscal Year 2005. Section 3116 of the NDAA requires the U.S. Department of Energy (DOE) to consult with the NRC for certain non-high level waste determinations and also requires NRC to monitor DOE's disposal actions related to those determinations. In Fiscal Year 2005, the NRC staff began consulting with DOE and completed reviews of draft waste determinations for salt waste at the Savannah River Site. In 2006, a second review was completed on tank waste residuals including sodium-bearing waste at the Idaho Nuclear Technology and Engineering Center Tank Farm at the Idaho National Laboratory. Monitoring Plans were developed for these activities and the NRC is actively monitoring disposal actions at both sites. NRC is currently in consultation with DOE on the F-Area Tank Farm closure and anticipates entering consultation on the H-Area Tank Farm at the Savannah River Site. This paper presents, from the NRC perspective, an overview of how the consultation and monitoring process has evolved since its conception in 2005. It addresses changes in methods and procedures used to collect and develop information used by the NRC in developing the technical evaluation report and monitoring plan under consultation and the implementation the plan under monitoring. It will address lessons learned and best practices developed throughout the process. The NDAA has presented significant challenges for the NRC and DOE. Past and current successes demonstrate that the NDAA can achieve its intended goal of facilitating tank closure at DOE legacy defense waste sites. The NRC believes many of the challenges in performing the WD reviews have been identified and addressed. Lessons learned have been collected and documented throughout the review process. Future success will be contingent on each agencies commitment to

  8. An overview of public health service health-related activities as they relate to the Department of Energy's environmental restoration program

    International Nuclear Information System (INIS)

    Kocher, P.L.; Bashor, M.M.

    1991-01-01

    The Agency for Toxic Substances and Disease Registry (ATSDR) was created by the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) as an agency of the Public Health Service. Under the Superfund Amendments and Reauthorization Act of 1986 (SARA; CERCLA as amended), the public health responsibilities of ATSDR were greatly expanded. Among the responsibilities are (1) preparing health assessments for each site proposed for or listed on the National Priorities List (NPL) established by the US Environmental Protection Agency; (2) conducting epidemiologic and other health studies around NPL sites; (3) establishing registries of exposed individuals; (4) establishing health surveillance programs; (5) developing toxicological profiles for hazardous substances; (6) performing health and emergency response consultations; and (7) performing other health-related activities (e.g., health education). In October 1990, ATSDR signed a memorandum of understanding (MOU) with the Department of Energy (DOE) headquarters requiring that DOE operations offices sign interagency agreements (IAGs) with ATSDR for its conduct of 104(i) health activities at DOE sites. These activities include health assessments, related health studies such as surveillance programs, epidemiologic studies, and registries of exposed persons, and toxicological profiles of hazardous substances unique to DOE sites. ATSDR's studies will focus more on an assessment of the health risk to human populations residing in and around DOE sites than on an evaluation of the health risk to workers on site. Nevertheless, CERCLA, the MOU, and site-specific IAGs authorize ATSDR's access to health and environmental data concerning each site. The IAGs contemplate that ATSDR work closely with DOE operations offices in their implementation of their respective environmental restoration programs

  9. YALINA facility a sub-critical Accelerator- Driven System (ADS) for nuclear energy research facility description and an overview of the research program (1997-2008).

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, Y.; Smith, D. L.; Nuclear Engineering Division

    2010-04-28

    The YALINA facility is a zero-power, sub-critical assembly driven by a conventional neutron generator. It was conceived, constructed, and put into operation at the Radiation Physics and Chemistry Problems Institute of the National Academy of Sciences of Belarus located in Minsk-Sosny, Belarus. This facility was conceived for the purpose of investigating the static and dynamic neutronics properties of accelerator driven sub-critical systems, and to serve as a neutron source for investigating the properties of nuclear reactions, in particular transmutation reactions involving minor-actinide nuclei. This report provides a detailed description of this facility and documents the progress of research carried out there during a period of approximately a decade since the facility was conceived and built until the end of 2008. During its history of development and operation to date (1997-2008), the YALINA facility has hosted several foreign groups that worked with the resident staff as collaborators. The participation of Argonne National Laboratory in the YALINA research programs commenced in 2005. For obvious reasons, special emphasis is placed in this report on the work at YALINA facility that has involved Argonne's participation. Attention is given here to the experimental program at YALINA facility as well as to analytical investigations aimed at validating codes and computational procedures and at providing a better understanding of the physics and operational behavior of the YALINA facility in particular, and ADS systems in general, during the period 1997-2008.

  10. Superfund TIO videos. Set A. Regulatory overview - CERCLA's relationship to other programs: RCRA, Title III, UST, CWA, SDWA. Part 1. Audio-Visual

    International Nuclear Information System (INIS)

    1990-01-01

    The videotape is divided into five sections. Section 1 provides definitions and historical information on both the Resource Conservation and Recovery Act (RCRA) and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The four types of RCRA regulatory programs - Subtitles C, D, I, and J - are described. Treatment, storage, and disposal (TSD) and recycling facilities are also discussed. Section 2 discusses the history behind the Emergency Planning and Community Right-to-Know Act (Title III). The four major provisions of Title III, which are emergency planning, emergency release notification, community right-to-know reporting, and the toxic chemical release inventory are covered. Section 3 outlines the UST program covering notification, record keeping, and the UST Trust Fund. Section 4 outlines the six major provisions of the Clean Water Act (CWA): water quality, pretreatment, prevention of oil and hazardous substance discharges, responses to oil and hazardous substance discharges, discharges of hazardous substances into the ocean, and dredge and fill. Section 5 explains the purpose, regulations, and standards of the Safe Drinking Water Act (SDWA). Specific issues such as underground injection, sole source aquifers, and lead contamination are discussed

  11. NOAA Office of Exploration and Research > Education > Overview

    Science.gov (United States)

    Organization Guiding Documents Organizational Structure Map of Staff and Affiliate Locations Strategic Plan Evaluation Education Overview Home About OER Overview Organization Guiding Documents Organizational Structure The mission of the OER Education Program is to support OER's vision and mission by reaching out in new

  12. Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group.

    Science.gov (United States)

    Shak, S

    1999-08-01

    The recombinant humanized anti-HER2 monoclonal antibody trastuzumab (Herceptin; Genentech, San Francisco, CA) was evaluated in human clinical trials for treatment of women with metastatic breast cancer who have tumors that overexpress HER2. The trastuzumab clinical program consisted of a series of phase I, phase II, and phase III clinical trials. Clinical experience with this novel biologic has been obtained in more than 1,000 women with HER2-overexpressing metastatic breast cancer. Two pivotal trials were performed to evaluate trastuzumab efficacy and safety: (1) trastuzumab in combination with chemotherapy as first-line therapy and (2) trastuzumab as a single agent in second- and third-line chemotherapy. Preliminary results of the pivotal clinical trials that have been presented at national meetings are summarized below. The data suggest that trastuzumab will be an important new treatment option for women with HER2-overexpressing metastatic breast cancer.

  13. Integrated process status overview

    International Nuclear Information System (INIS)

    Gertman, D.I.; Gaudio, P. Jr.

    1986-01-01

    This report summarizes findings to date with the IPSO, a large plant status overview currently under development at the OECD Halden Reactor Project. As part of a joint Halden and Combustion Engineering project, the overview is being tested in part to determine whether the large screen overview concept being entertained for use in the nuclear power plant (NPP) industry will facilitate operator performance. To this end an interactive simulation technique was used to establish a proof-of-principle test for the IPSO. Process control, operations, and human factors experts at Halden participated in the test and evaluation

  14. A mobile phone-based, community health worker program for referral, follow-up, and service outreach in rural Zambia: outcomes and overview.

    Science.gov (United States)

    Schuttner, Linnaea; Sindano, Ntazana; Theis, Mathew; Zue, Cory; Joseph, Jessica; Chilengi, Roma; Chi, Benjamin H; Stringer, Jeffrey S A; Chintu, Namwinga

    2014-08-01

    Mobile health (m-health) utilizes widespread access to mobile phone technologies to expand health services. Community health workers (CHWs) provide first-level contact with health facilities; combining CHW efforts with m-health may be an avenue for improving primary care services. As part of a primary care improvement project, a pilot CHW program was developed using a mobile phone-based application for outreach, referral, and follow-up between the clinic and community in rural Zambia. The program was implemented at six primary care sites. Computers were installed at clinics for data entry, and data were transmitted to central servers. In the field, using a mobile phone to send data and receive follow-up requests, CHWs conducted household health surveillance visits, referred individuals to clinic, and followed up clinic patients. From January to April 2011, 24 CHWs surveyed 6,197 households with 33,304 inhabitants. Of 15,539 clinic visits, 1,173 (8%) had a follow-up visit indicated and transmitted via a mobile phone to designated CHWs. CHWs performed one or more follow-ups on 74% (n=871) of active requests and obtained outcomes on 63% (n=741). From all community visits combined, CHWs referred 840 individuals to a clinic. CHWs completed all planned aspects of surveillance and outreach, demonstrating feasibility. Components of this pilot project may aid clinical care in rural settings and have potential for epidemiologic and health system applications. Thus, m-health has the potential to improve service outreach, guide activities, and facilitate data collection in Zambia.

  15. Making healthy eating and physical activity policy practice: the design and overview of a group randomized controlled trial in afterschool programs.

    Science.gov (United States)

    Beets, Michael W; Glenn Weaver, R; Turner-McGrievy, Gabrielle; Huberty, Jennifer; Ward, Dianne S; Freedman, Darcy A; Saunders, Ruth; Pate, Russell R; Beighle, Aaron; Hutto, Brent; Moore, Justin B

    2014-07-01

    National and state organizations have developed policies calling upon afterschool programs (ASPs, 3-6 pm) to serve a fruit or vegetable (FV) each day for snack, while eliminating foods and beverages high in added-sugars, and to ensure children accumulate a minimum of 30 min/d of moderate-to-vigorous physical activity (MVPA). Few efficacious and cost-effective strategies exist to assist ASP providers in achieving these important public health goals. This paper reports on the design and conceptual framework of Making Healthy Eating and Physical Activity (HEPA) Policy Practice in ASPs, a 3-year group randomized controlled trial testing the effectiveness of strategies designed to improve snacks served and increase MVPA in children attending community-based ASPs. Twenty ASPs, serving over 1800 children (6-12 years) will be enrolled and match-paired based on enrollment size, average daily min/d MVPA, and days/week FV served, with ASPs randomized after baseline data collection to immediate intervention or a 1-year delayed group. The framework employed, STEPs (Strategies To Enhance Practice), focuses on intentional programming of HEPA in each ASPs' daily schedule, and includes a grocery store partnership to reduce price barriers to purchasing FV, professional development training to promote physical activity to develop core physical activity competencies, as well as ongoing technical support/assistance. Primary outcome measures include children's accelerometry-derived MVPA and time spend sedentary while attending an ASP, direct observation of staff HEPA promoting and inhibiting behaviors, types of snacks served, and child consumption of snacks, as well as, cost of snacks via receipts and detailed accounting of intervention delivery costs to estimate cost-effectiveness. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Making Healthy Eating and Physical Activity Policy Practice: The Design and Overview of a Group Randomized Controlled Trial in Afterschool Programs

    Science.gov (United States)

    Beets, Michael W.; Weaver, R. Glenn; Turner-McGrievy, Gabrielle; Huberty, Jennifer; Ward, Dianne S.; Freedman, Darcy A.; Saunders, Ruth; Pate, Russell R.; Beighle, Aaron; Moore, Justin B.

    2014-01-01

    National and state organizations have developed policies calling upon afterschool programs (ASPs, 3-6pm) to serve a fruit or vegetable (FV) each day for snack, while eliminating foods and beverages high in added-sugars, and to ensure children accumulate a minimum of 30 min/d of moderate-to-vigorous physical activity (MVPA). Few efficacious and cost-effective strategies exist to assist ASP providers in achieving these important public health goals. This paper reports on the design and conceptual framework of Making Healthy Eating and Physical Activity (HEPA) Policy Practice in ASPs, a 3-year group randomized controlled trial testing the effectiveness of strategies designed to improve snacks served and increase MVPA in children attending community-based ASPs. Twenty ASPs, serving over 1,800 children (6-12yrs) will be enrolled and match-paired based on enrollment size, average daily min/d MVPA, and days/week FV served, with ASPs randomized after baseline data collection to immediate intervention or a 1-year delayed group. The framework employed, STEPs (Strategies To Enhance Practice), focuses on intentional programming of HEPA in each ASPs’ daily schedule, and includes a grocery store partnership to reduce price barriers to purchasing FV, professional development training to promote physical activity to develop core physical activity competencies, as well as ongoing technical support/assistance. Primary outcome measures include children’s accelerometry-derived MVPA and time spend sedentary while attending an ASP, direct observation of staff HEPA promoting and inhibiting behaviors, types of snacks served, and child consumption of snacks, as well as, cost of snacks via receipts and detailed accounting of intervention delivery costs to estimate cost-effectiveness. PMID:24893225

  17. Fims, forestry information management system: An overview

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This geographic information system has been developed as part of Forestry Canada's Eastern Quebec Forestry Program for woodlot owners in eastern Quebec. The goal was to provide private woodlot operators with a management system that uses the most advanced technology available. This booklet provides an overview of this system, explaining how the system can be used.

  18. Nevada Operations overview

    International Nuclear Information System (INIS)

    Church, B.W.

    1981-01-01

    A brief overview is given of weapon test site decontamination activities carried out by Nevada Operations Office. Tabulated data is given of event name, date, location, year of cleanup, and radioisotopes that were present, activity levels, and cost of cleanup

  19. EURO HAWK Project Overview

    National Research Council Canada - National Science Library

    2003-01-01

    Briefing charts from presentation on a EURO HAWK project overview; an airborne system with stand-off capability for wide-area intelligence, surveillance and reconnaissance meeting European NATO countries' ISR requirements...

  20. Overview of Movement Disorders

    Science.gov (United States)

    ... of Delirium Additional Content Medical News Overview of Movement Disorders By Hector A. Gonzalez-Usigli, MD, Professor ... Neurology, HE UMAE Centro Médico Nacional de Occidente; Movement Disorders Clinic, Neurology at IMSS Alberto Espay, MD, ...