Thio-, selenido-, and telluridogermanates(III): K/sub 6/Ge/sub 2/S/sub 6/, K/sub 6/Ge/sub 2/Se/sub 6/, and Na/sub 6/Ge/sub 2/Te/sub 6/

Energy Technology Data Exchange (ETDEWEB)

Eisenmann, B; Kieselbach, E; Schaefer, H; Schrod, H [Technische Hochschule Darmstadt (Germany, F.R.). Fachbereich Anorganische Chemie und Kernchemie

1984-09-01

The new compounds K/sub 6/Ge/sub 2/S/sub 6/ and K/sub 6/Ge/sub 2/Se/sub 6/ crystallize in the monoclinic system, space group C2/m (No 12). The compounds are isotypic and form the K/sub 6/Si/sub 2/Te/sub 6/ structure. Na/sub 6/Ge/sub 2/Te/sub 6/ crystallizes in the K/sub 6/Sn/sub 2/Te/sub 6/ structure, monoclinic, space group P2/sub 1//c (No 14). The lattice constants are given.

Canonical duality theory unified methodology for multidisciplinary study

CERN Document Server

Latorre, Vittorio; Ruan, Ning

2017-01-01

This book on canonical duality theory provides a comprehensive review of its philosophical origin, physics foundation, and mathematical statements in both finite- and infinite-dimensional spaces. A ground-breaking methodological theory, canonical duality theory can be used for modeling complex systems within a unified framework and for solving a large class of challenging problems in multidisciplinary fields in engineering, mathematics, and the sciences. This volume places a particular emphasis on canonical duality theory’s role in bridging the gap between non-convex analysis/mechanics and global optimization.  With 18 total chapters written by experts in their fields, this volume provides a nonconventional theory for unified understanding of the fundamental difficulties in large deformation mechanics, bifurcation/chaos in nonlinear science, and the NP-hard problems in global optimization. Additionally, readers will find a unified methodology and powerful algorithms for solving challenging problems in comp...

Unified field theory

International Nuclear Information System (INIS)

Prasad, R.

1975-01-01

Results of researches into Unified Field Theory over the past seven years are presented. The subject is dealt with in chapters entitled: the choice of affine connection, algebraic properties of the vector fields, field laws obtained from the affine connection based on the path integral method, application to quantum theory and cosmology, interpretation of physical theory in terms of geometry. (U.K.)

Ontology-based Metadata Portal for Unified Semantics

Data.gov (United States)

National Aeronautics and Space Administration — The Ontology-based Metadata Portal for Unified Semantics (OlyMPUS) will extend the prototype Ontology-Driven Interactive Search Environment for Earth Sciences...

Distribution of strontium in DB18K6 and DTBDB18K6 systems

International Nuclear Information System (INIS)

Usarov, Z.O.; Khujaev, S.

2007-01-01

Distributions of strontium in DB18K6 and DTBDB18K6 crown-ethers in chloroform were investigated for extraction of strontium from water solutions of nitric acid. Nitrate solutions with various pH were considered. In both crown-ethers the most extraction of strontium was observed for the moderate pH values. Equilibrium of extraction process is reached for comparatively short time and is occurred to be 20 min (authors)

Structural investigation on K3Gd5(PO4)6 in between 20 K to 1073 K

International Nuclear Information System (INIS)

Bevara, Samatha; Achary, S.N.; Tyagi, A.K.; Mishra, K.K.; Ravindran, T.R.; Sinha, A.K.; Sastry, P.U.

2016-01-01

Evolution of crystal structure of K 3 Gd 5 (PO 4 ) 6 in the temperature range from 20 K to 1073 K, as observed from combined variable temperature X-ray diffraction (using both synchrotron source and Cu K α lab source) and Raman spectroscopic studies is communicated in the manuscript. The title compound has an open tunnel containing three dimensional structure built by periodic arrangements of (Gd 5 (PO 4 ) 6 ) 3- ions which in turn are formed by PO 4 tetrahedra and GdO n (n = 8 and 9) polyhedra and these tunnels are occupied by K + ions. The XRD patterns in the entire temperature range of study indicated no change in the crystal structural, which is also supported by differential thermal analyses and Raman spectroscopy. Average axial thermal expansion coefficients between 20K and 1073 K are : α a =10.6 x 10 -6 K -1 , α b = 5.5 x 10 -6 K -1 and α c = 16.4 X 10.6 -6 K -1 . (author)

Technological Studies at Thomas Edison Middle School. Grades 6-7-8.

Science.gov (United States)

Foster, Patrick N.

This technology studies curriculum for grades 6-8 is a plan for each middle school student to experience technology education for approximately 60 days (1 trimester of a 180-day school year) in each grade. Section A provides definitions; structure or content for grade-level programs with science and technology unifiers (unifying curricular…

The system K2NbF7-K2TiF6-KCl

International Nuclear Information System (INIS)

Kamenskaya, L.A.; Matveev, A.M.

1984-01-01

Using visual-polythermal and thermographical methods the ternary system K 2 NbF 7 -K 2 TiE 6 -KCl has been studied. Crystallization fields of initial components and the field of solid solutions of double compounds K 3 NbClF 7 and K 3 TiClF 6 are outlined. Ternary eutectics at 654 deg C, having the composition K 2 NbF 6 -41, K 2 TiP 6 -41, KCl-18 mol.%, is determined. Potassium fluoroniobate and fluorotitanate form continuous solid solutions unstable in the presence of the third component, potassium chloride

Carnap on unified science

Czech Academy of Sciences Publication Activity Database

Klev, Ansten

-, č. 59 (2016), s. 53-67 ISSN 0039-3681 Institutional support: RVO:67985955 Keywords : Rudolf Carnap * Unity of Science * Logical Empiricism Subject RIV: AA - Philosophy ; Religion Impact factor: 0.723, year: 2016 http://www.sciencedirect.com/science/article/pii/S0039368116300206

Earth Science Community IT Resources through a Unified Data and Analysis Portal

Science.gov (United States)

Bock, Y.; Webb, F. H.; Kedar, S.; Pierce, M.; Scharber, M.; Argus, D. F.; Aydin, G.; Chang, R.; Dong, D.; Fang, P.; Granat, R. A.; Jamason, P.; Newport, B. J.; Owen, S. E.; Parker, J. W.; Prawirodirdjo, L.; Vernon, F.; Wadsworth, G.

2006-12-01

We are in the process of merging the capabilities of three NASA-funded projects under the umbrella of the NASA Access Project, "Modeling and On-the-fly Solutions for Solid Earth Sciences (MOSES)" to facilitate data mining and modeling of rapidly expanding multi-disciplinary geoscience data sets. (1) The SCIGN- REASoN project is focused on the combination, validation, archive, and delivery of high-level data products and data mining capabilities from space geodetic measurements, in particular from over 600 CGPS stations in Western North America; (2) The QuakeSim project is developing linked Web service environments for supporting high performance models of crustal deformation from a variety of geophysical sensors, including GPS and seismic instruments; (3) The SENH-Applications GPS/Seismic integration project has developed a prototype real-time GPS/seismic displacement meter for seismic hazard mitigation and monitoring of critical infrastructure. The focus of the MOSES project is to enable direct interaction between modelers and data/data-product providers using Web services, within a unified portal architecture. Modeling applications include, for example, time series analysis of continuous and real-time data (e.g., RDAHMM and st_filter programs) and fault dislocation modeling (e.g., Simplex program). Community resources include access to extensive infrastructure and distributed data archive holdings, an on-line map server/client linked to a GIS database, a "GPS Explorer" data portal that is extensible to heterogeneous data sets, and "Geophysical Resource Web Services." We present the current capabilities of the unified data and analysis portal, and provide a few examples of combinations of independent geophysical measurements.

A unifying philosophy of governance

Directory of Open Access Journals (Sweden)

Sankarshan Acharya

2012-09-01

Full Text Available Bertrand Russell won Nobel Prize for arguing that science has triumphed over religion. Since religions are based on god, Russell’s argument implies that science has triumphed over both religion and god. But neither Russell nor anyone else has ever defined religion and god, rationally. The assertion about triumph of science (which is founded on rationality over concepts such as religion and god (which are not defined rationally or scientifically in the extant literature cannot be rational. This paper offers a novel rational philosophical foundation for the concepts of god, religion and science in which the claim that science triumphs over religion is redundant. This paper also presents substantial new insights about epistemic truths to help resolve current problems facing humanity like financial moral hazard and terrorism which have unnerved nations worldwide. The humanity now begs to answer a fundamental question of how we can govern ourselves. This paper offers a coherent set of credible answers. In particular, it offers a coherent unified philosophy about how humans have universally formed beliefs to govern themselves and how this philosophy could help resolve current problems. The universal rendering of beliefs articulated here subsumes the extant characterization of probability beliefs in mathematics, science, engineering, economics, religion and philosophy. The universal beliefs so articulated in this paper obviate the currently prevalent philosophical conflicts between religion and science or between theism and atheism and paves the way for optimal governance for prosperity amid stability. This philosophy also offers a rational characterization of the spiritual notion of Nirvana or salvation of the soul and the notion of epistemic truth. The unifying philosophy can help humanity achieve unity, stability and prosperity, sans financial moral hazard, antagonism, wars, nuclear proliferation, global warming and atmospheric pollution.

Unified communications

OpenAIRE

Kravos, Urban

2011-01-01

In the modern business world, communication are becoming more and more complex. As a solution to this problem unified communications occurred. Using a single communication approach unified communications are the integration of various communication technologies (eg, telephony, unified messaging, audio, video and web conferencing and collaboration tools). Unified Messaging, which represents only part of the unified communications means the integration of different non real time communication t...

Model of unified gauge fields; Le modele des champs de jauge unifies

Energy Technology Data Exchange (ETDEWEB)

Leite Lopes, J. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)

1998-04-01

In this work, we discuss the physical ideas which represents the basis for the unified gauge field model. Despite of the difficulties that we presently have for embodying in a natural manner muons and hadrons in that model, we have the feeling that we are on the way which seems to lead to the construction of a theory in which the Maxwell electromagnetic field and the Fermi weak interaction field are manifestations of a unique subjacent physical entity - the unified gauge fields. (author) 22 refs., 6 figs.

A K Meikap

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Meikap. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 649-652 Alloys and Steels. An X-ray diffraction study of defect parameters in a Ti-base alloy · G Karmaker P Mukherjee A K Meikap S K Chattopadhyay S K Chatterjee.

Grand unified theories

International Nuclear Information System (INIS)

Rosner, J.L.

1987-01-01

This paper reports on a pedagogical introduction that attempts to unify the strong and electroweak interactions. Unifying groups discussed include SU(5), SO(10), and E 6 . Particular attention is paid to the questions of whether the low-energy gauge group (that accessible at accelerator experiments in the foreseeable future) extends beyond SU(3) x SU(2) L x U(1). Low-energy studies of neutral-current effects, direct production of gauge bosons, and new fermions all can shed light on this question. Brief remarks are made concerning the role of monopoles, cosmic strings, baryogenesis, supersymmetry, and higher dimensions in this program

Unifying physical concepts of reality

Energy Technology Data Exchange (ETDEWEB)

Gilbert, T.L.

1983-08-01

Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences.

Unifying physical concepts of reality

International Nuclear Information System (INIS)

Gilbert, T.L.

1983-01-01

Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences

Investigation of a Unified Chaotic System and Its Synchronization by Simulations

International Nuclear Information System (INIS)

Qing-Chu, Wu; Xin-Chu, Fu; Small, Michael

2010-01-01

We investigate a unified chaotic system and its synchronization including feedback synchronization and adaptive synchronization by numerical simulations. We propose a new dynamical quantity denoted by K, which connects adaptive synchronization and feedback synchronization, to analyze synchronization schemes. We find that K can estimate the smallest coupling strength for a unified chaotic system whether it is complete feedback or one-sided feedback. Based on the previous work, we also give a new dynamical method to compute the leading Lyapunov exponent. (general)

A K Singh

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Singh. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 633-638 Alloys and Steels. Analysis of stainless steel samples by energy dispersive X-ray fluorescence (EDXRF) spectrometry · M K Tiwari A K Singh K J S Sawhney · More Details ...

Rational Unified Process

OpenAIRE

Kopal, Nils

2016-01-01

In this German seminar paper, which was written in the year 2011 at the University of Duisburg for a Bachelor Colloquium in Applied computer science, we show a brief overview of the Rational Unified Process (RUP). Thus, interested students or generally interested people in software development gain a first impression of RUP. The paper includes a survey and overview of the underlying process structure, the phases of the process, its workflows, and describes the always by the RUP developers pos...

Assessment Strategies for Implementing Ngss in K12 Earth System Science Classrooms

Science.gov (United States)

McAuliffe, C.

2016-12-01

Several science education researchers have led assessment efforts that provide strategies particularly useful for evaluating the threedimensional learning that is central to NGSS (DeBarger, A. H., Penuel, W. R., Harris, C. J., Kennedy, C. K., 2016; Knight, A. M. & McNeill, K. L., 2015; McNeill, K. L., KatshSinger, R. & Pelletier, P., 2015; McNeill K.L., et.al., 2015; McNeill, K.L., & Krajcik, J.S., 2011; Penuel, W., 2016). One of the basic premises of these researchers is that, "Assessment is a practice of argument from evidence based on what students say, do, and write" and that "the classroom is the richest place to gather evidence of what students know (Penuel, W., 2016). The implementation of the NGSS in Earth System Science provides a unique opportunity for geoscience education researchers to study student learning and contribute to the development of this research as well as for geoscience educators to apply these approaches and strategies in their own work with K12 inservice and preservice educators. DeBarger, A. H., Penuel, W. R., Harris, C. J., Kennedy, C. K. (2016). Building an Assessment Argument to Design and Use Next Generation Science Assessments in Efficacy Studies of Curriculum Interventions. American†Journal†of†Evaluation†37(2) 174192Æ Knight, A. M. & McNeill, K. L. (2015). Comparing students' individual written and collaborative oral socioscientific arguments. International Journal of Environmental and Science Education.10(5), 23647. McNeill, K. L., KatshSinger, R. & Pelletier, P. (2015). Assessing science practices-Moving your class along a continuum. Science Scope. McNeill, K.L., & Krajcik, J.S. (2011). Supporting Grade 5-8 Students in Constructing Explanations in Science: The Claim, Evidence, and Reasoning Framework for Talk and Writing. Upper Saddle River, New Jersey: Pearson. Penuel, W. (2016). Classroom Assessment Strategies for NGSS Earth and Space Sciences. Implementing†the†NGSS†Webinar†Series, February 11, 2016.

C K Maiti

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. C K Maiti. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 579-582 Thin Films. Metallo–organic compound-based plasma enhanced CVD of ZrO2 films for microelectronic applications · S Chatterjee S K Samanta H D Banerjee C K Maiti.

A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals

International Nuclear Information System (INIS)

Peyret, Thomas; Poulin, Patrick; Krishnan, Kannan

2010-01-01

The algorithms in the literature focusing to predict tissue:blood PC (P tb ) for environmental chemicals and tissue:plasma PC based on total (K p ) or unbound concentration (K pu ) for drugs differ in their consideration of binding to hemoglobin, plasma proteins and charged phospholipids. The objective of the present study was to develop a unified algorithm such that P tb , K p and K pu for both drugs and environmental chemicals could be predicted. The development of the unified algorithm was accomplished by integrating all mechanistic algorithms previously published to compute the PCs. Furthermore, the algorithm was structured in such a way as to facilitate predictions of the distribution of organic compounds at the macro (i.e. whole tissue) and micro (i.e. cells and fluids) levels. The resulting unified algorithm was applied to compute the rat P tb , K p or K pu of muscle (n = 174), liver (n = 139) and adipose tissue (n = 141) for acidic, neutral, zwitterionic and basic drugs as well as ketones, acetate esters, alcohols, aliphatic hydrocarbons, aromatic hydrocarbons and ethers. The unified algorithm reproduced adequately the values predicted previously by the published algorithms for a total of 142 drugs and chemicals. The sensitivity analysis demonstrated the relative importance of the various compound properties reflective of specific mechanistic determinants relevant to prediction of PC values of drugs and environmental chemicals. Overall, the present unified algorithm uniquely facilitates the computation of macro and micro level PCs for developing organ and cellular-level PBPK models for both chemicals and drugs.

Lunar and Planetary Science XXXV: Engaging K-12 Educators, Students, and the General Public in Space Science Exploration

Science.gov (United States)

2004-01-01

The session "Engaging K-12 Educators, Students, and the General Public in Space Science Exploration" included the following reports:Training Informal Educators Provides Leverage for Space Science Education and Public Outreach; Teacher Leaders in Research Based Science Education: K-12 Teacher Retention, Renewal, and Involvement in Professional Science; Telling the Tale of Two Deserts: Teacher Training and Utilization of a New Standards-based, Bilingual E/PO Product; Lindstrom M. M. Tobola K. W. Stocco K. Henry M. Allen J. S. McReynolds J. Porter T. T. Veile J. Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes -- Update; Utilizing Mars Data in Education: Delivering Standards-based Content by Exposing Educators and Students to Authentic Scientific Opportunities and Curriculum; K. E. Little Elementary School and the Young Astronaut Robotics Program; Integrated Solar System Exploration Education and Public Outreach: Theme, Products and Activities; and Online Access to the NEAR Image Collection: A Resource for Educators and Scientists.

Problem-Based Learning in the Life Science Classroom, K-12

Science.gov (United States)

McConnell, Tom; Parker, Joyce; Eberhardt, Janet

2016-01-01

"Problem-Based Learning in the Life Science Classroom, K-12" offers a great new way to ignite your creativity. Authors Tom McConnell, Joyce Parker, and Janet Eberhardt show you how to engage students with scenarios that represent real-world science in all its messy, thought-provoking glory. The scenarios prompt K-12 learners to immerse…

Unifying the Universe the physics of heaven and earth

CERN Document Server

Padamsee, Hasan S

2003-01-01

Unifying the Universe: The Physics of Heaven and Earth provides a solid background in basic physics. With a humanistic perspective, it shows how science is significant for more than its technological consequences. The book includes clear and well-planned links to the arts and philosophies of relevant historical periods to bring science and the humanities together.

manoj k mitra

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. MANOJ K MITRA. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1203-1211. One-pot synthesis of CaAl-layered double hydroxide–methotrexate nanohybrid for anticancer application · MANJUSHA CHAKRABORTY MANOJ K MITRA JUI ...

K B Sinha

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K B Sinha. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 6 June 1998 pp 80-81 Book Review. Algebra in Ancient and Modern Times · K B Sinha · More Details Fulltext PDF ...

K Hussian Reddy

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K Hussian Reddy. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 6 June 1999 pp 67-77 General Article. Coordination Compounds in Biology - The Chemistry of Vitamin B12 and Model Compounds · K Hussian Reddy.

Grand unified theories

International Nuclear Information System (INIS)

Langacker, P.

1981-01-01

In this talk I discuss the present status of these theories and of their observational and experimental implications. In section II, I briefly review the standard SU 3 sup(c) x SU 2 x U 1 model of the strong and electroweak interactions. Although phenomenologically successful, the standard model leaves many questions unanswered. Some of these questions are addressed by grand unified theories, which are defined and discussed in Section III. The Georgi-Glashow SU 5 model is described, as are theories based on larger groups such as SO 10 , E 6 , or SO 16 . It is emphasized that there are many possible grand unified theories and that it is an experimental problem not only to test the basic ideas but to discriminate between models. (orig./HSI)

K J Rao

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K J Rao. Articles written in Bulletin of Materials Science. Volume 23 Issue 6 December 2000 pp 461-466 Material Synthesis. Microwave synthesis of electrode materials for lithium batteries · M Harish Bhat B P Chakravarthy P A Ramakrishnan A Levasseur K J RAO.

K A Malini

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K A Malini. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 623-631 Magnetic Materials. Tailoring magnetic and dielectric properties of rubber ferrite composites containing mixed ferrites · M R Anantharaman K A Malini S Sindhu E M ...

Constructing 5d orbifold grand unified theories from heterotic strings

International Nuclear Information System (INIS)

Kobayashi, Tatsuo; Raby, Stuart; Zhang Renjie

2004-01-01

A three-generation Pati-Salam model is constructed by compactifying the heterotic string on a particular T 6 /Z 6 Abelian symmetric orbifold with two discrete Wilson lines. The compactified space is taken to be the Lie algebra lattice G 2 -bar SU(3)-bar SO(4). When one dimension of the SO(4) lattice is large compared to the string scale, this model reproduces many features of a 5d SO(10) grand unified theory compactified on an S 1 /Z 2 orbifold. (Of course, with two large extra dimensions we can obtain a 6d SO(10) grand unified theory.) We identify the orbifold parities and other ingredients of the orbifold grand unified theories in the string model. Our construction provides a UV completion of orbifold grand unified theories, and gives new insights into both field theoretical and string theoretical constructions

New grand unified models with intersecting D6-branes, neutrino masses, and flipped SU(5)

Energy Technology Data Exchange (ETDEWEB)

Cvetic, Mirjam [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104-6396 (United States)]. E-mail: cvetic@cvetic.hep.upenn.edu; Langacker, Paul [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104-6396 (United States); School of Natural Sciences, Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540 (United States)

2007-07-30

We construct new supersymmetric SU(5) grand unified models based on Z{sub 4}xZ{sub 2} orientifolds with intersecting D6-branes. Unlike constructions based on Z{sub 2}xZ{sub 2} orientifolds, the orbifold images of the three-cycles wrapped by D6-branes correspond to new configurations and thus allow for models in which, in addition to the chiral sector in 10 and 5-bar representations of SU(5), only, there can be new sectors with (15+15-bar) and (10+10-bar) vector-pairs. We construct an example of such a globally consistent, supersymmetric model with four-families, two Standard Model Higgs pair-candidates and the gauge symmetry U(5)xU(1)xSp(4). In an N=2 sector, there are 5x(15+15-bar) and 1x(10+10-bar) vector-pairs, while another N=1 sector contains one vector-pair of 15-plets. The N=2 vector-pairs can obtain a large mass dynamically by parallel D6-brane splitting in a particular two-torus. The 15-vector-pairs provide, after symmetry breaking to the Standard Model (via parallel D-brane splitting), triplet pair candidates which can in principle play a role in generating Majorana-type masses for left-handed neutrinos, though the necessary Yukawa couplings are absent in the specific construction. This model can also be interpreted as a flipped SU(5)xU(1){sub X} grand unified model where the 10-vector-pairs can play the role of Higgs fields, though again there are phenomenological difficulties for the specific construction.

P K Sumodan

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. P K Sumodan. Articles written in Resonance – Journal of Science Education. Volume 6 Issue 5 May 2001 pp 48-55 General Article. The Tiny Terminators - Mosquitoes and Diseases · P K Sumodan · More Details Fulltext PDF. Volume 7 Issue 8 August 2002 pp ...

Preservice Teachers' Perspectives on 'Appropriate' K-8 Climate Change and Environmental Science Topics

Science.gov (United States)

Ford, D. J.

2013-12-01

With the release of the Next Generation Science Standards (NRC, 2013), climate change and related environmental sciences will now receive greater emphasis within science curricula at all grade levels. In grades K-8, preparation in foundational content (e.g., weather and climate, natural resources, and human impacts on the environment) and the nature of scientific inquiry will set the groundwork for later learning of climate change in upper middle and high school. These rigorous standards increase pressure on elementary and middle school teachers to possess strong science content knowledge, as well as experience supporting children to develop scientific ideas through the practices of science. It also requires a set of beliefs - about children and the science that is appropriate for them - that is compatible with the goals set out in the standards. Elementary teachers in particular, who often have minimal preparation in the earth sciences (NSF, 2007), and entrenched beliefs about how particular topics ought to be taught (Holt- Reynolds, 1992; Pajares, 1992), including climate change (Bryce & Day, 2013; Lambert & Bleicher, 2013), may face unique challenges in adjusting to the new standards. If teachers hold beliefs about climate change as controversial, for example, they may not consider it an appropriate topic for children, despite its inclusion in the standards. On the other hand, those who see a role for children in efforts to mitigate human impacts on the environment may be more enthusiastic about the new standards. We report on a survey of preservice K-8 teachers' beliefs about the earth and environmental science topics that they consider to be appropriate and inappropriate for children in grades K-3, 4-5, and 6-8. Participants were surveyed on a variety of standards-based topics using terminology that signals publicly and scientifically neutral (e.g. weather, ecosystems) to overtly controversial (evolution, global warming) science. Results from pilot data

Unifying Physics

Science.gov (United States)

Goradia, Shantilal

2013-04-01

Century old GR fails to unify quantum physics, nuclear force or distinguish between the mass of living bodies from inert mass. Probabilistic gravity [1] explains strong coupling (nuclear force). The natural log of the age of the universe, 10E60 in Planck times, equaling 137 (1/Alpha) extends physics to deeper science, if we stand on the shoulders of giants like Feynman and Gamow. Implications of [1] are that it is not the earth, but M and S numbers of the particles of the earth are remotely interacting with corresponding numbers of the particles of the moon and the sun respectively, neglecting other heavenly bodies in this short draft. This new physics is likely to enable creative scientific minds to throw light on a theoretical basis for an otherwise arbitrary cosmological constant, uniformity of microwave background, further vindication of Boltzmann, quantum informatics, Einstein’s later publicized views and more, eliminating the need to spend money for implicitly nonexistent quantum gravity and graviton.[4pt] [1] Journal of Physical Science and Applications 2 (7) (2012) 265-268.

Increasing ocean sciences in K and 1st grade classrooms through ocean sciences curriculum aligned to A Framework for K-12 Science Education, and implementation support.

Science.gov (United States)

Pedemonte, S.; Weiss, E. L.

2016-02-01

Ocean and climate sciences are rarely introduced at the early elementary levels. Reasons for this vary, but include little direct attention at the national and state levels; lack of quality instructional materials; and, lack of teacher content knowledge. Recent recommendations by the National Research Council, "revise the Earth and Space sciences core ideas and grade band endpoints to include more attention to the ocean whenever possible" (NRC, 2012, p. 336) adopted in the Next Generation Science Standards (NGSS), may increase the call for ocean and climate sciences to be addressed. In response to these recommendations' and the recognition that an understanding of some of the Disciplinary Core Ideas (DCIs) would be incomplete without an understanding of processes or phenomena unique to the ocean and ocean organisms; the ocean Literacy community have created documents that show the alignment of NGSS with the Ocean Literacy Principles and Fundamental Concepts (Ocean Literacy, 2013) as well as the Ocean Literacy Scope and Sequence for Grades K-12 (Ocean Literacy, 2010), providing a solid argument for how and to what degree ocean sciences should be part of the curriculum. However, the percentage of science education curricula focused on the ocean remains very low. This session will describe a new project, that draws on the expertise of curriculum developers, ocean literacy advocates, and researchers to meet the challenges of aligning ocean sciences curriculum to NGSS, and supporting its implementation. The desired outcomes of the proposed project are to provide a rigorous standards aligned curricula that addresses all of the Life Sciences, and some Earth and Space Sciences and Engineering Design Core Ideas for Grades K and 1; and provides teachers with the support they need to understand the content and begin implementation. The process and lessons learned will be shared.

Unified functional network and nonlinear time series analysis for complex systems science: The pyunicorn package

Science.gov (United States)

Donges, Jonathan; Heitzig, Jobst; Beronov, Boyan; Wiedermann, Marc; Runge, Jakob; Feng, Qing Yi; Tupikina, Liubov; Stolbova, Veronika; Donner, Reik; Marwan, Norbert; Dijkstra, Henk; Kurths, Jürgen

2016-04-01

We introduce the pyunicorn (Pythonic unified complex network and recurrence analysis toolbox) open source software package for applying and combining modern methods of data analysis and modeling from complex network theory and nonlinear time series analysis. pyunicorn is a fully object-oriented and easily parallelizable package written in the language Python. It allows for the construction of functional networks such as climate networks in climatology or functional brain networks in neuroscience representing the structure of statistical interrelationships in large data sets of time series and, subsequently, investigating this structure using advanced methods of complex network theory such as measures and models for spatial networks, networks of interacting networks, node-weighted statistics, or network surrogates. Additionally, pyunicorn provides insights into the nonlinear dynamics of complex systems as recorded in uni- and multivariate time series from a non-traditional perspective by means of recurrence quantification analysis, recurrence networks, visibility graphs, and construction of surrogate time series. The range of possible applications of the library is outlined, drawing on several examples mainly from the field of climatology. pyunicorn is available online at https://github.com/pik-copan/pyunicorn. Reference: J.F. Donges, J. Heitzig, B. Beronov, M. Wiedermann, J. Runge, Q.-Y. Feng, L. Tupikina, V. Stolbova, R.V. Donner, N. Marwan, H.A. Dijkstra, and J. Kurths, Unified functional network and nonlinear time series analysis for complex systems science: The pyunicorn package, Chaos 25, 113101 (2015), DOI: 10.1063/1.4934554, Preprint: arxiv.org:1507.01571 [physics.data-an].

Towards a Grand Unified Theory of sports performance.

Science.gov (United States)

Glazier, Paul S

2017-12-01

Sports performance is generally considered to be governed by a range of interacting physiological, biomechanical, and psychological variables, amongst others. Despite sports performance being multi-factorial, however, the majority of performance-oriented sports science research has predominantly been monodisciplinary in nature, presumably due, at least in part, to the lack of a unifying theoretical framework required to integrate the various subdisciplines of sports science. In this target article, I propose a Grand Unified Theory (GUT) of sports performance-and, by elaboration, sports science-based around the constraints framework introduced originally by Newell (1986). A central tenet of this GUT is that, at both the intra- and inter-individual levels of analysis, patterns of coordination and control, which directly determine the performance outcome, emerge from the confluence of interacting organismic, environmental, and task constraints via the formation and self-organisation of coordinative structures. It is suggested that this GUT could be used to: foster interdisciplinary research collaborations; break down the silos that have developed in sports science and restore greater disciplinary balance to the field; promote a more holistic understanding of sports performance across all levels of analysis; increase explanatory power of applied research work; provide stronger rationale for data collection and variable selection; and direct the development of integrated performance monitoring technologies. This GUT could also provide a scientifically rigorous basis for integrating the subdisciplines of sports science in applied sports science support programmes adopted by high-performance agencies and national governing bodies for various individual and team sports. Copyright © 2017 Elsevier B.V. All rights reserved.

Bringing Inquiry Science to K-5 Classrooms

Science.gov (United States)

Schachtel, Paula L.; Messina, D. L.; McDermott, L. C.

2006-12-01

As a science coach in the Seattle School District, I am responsible for helping other elementary teachers teach science. For several years, I have been participating in a program that consists of intensive NSF Summer Institutes and an ongoing academic-year Continuation Course. Teachers in this program work through modules in Physics by Inquiry, a research-based curriculum developed by the Physics Education Group at the University of Washington.1 I will discuss how this type of professional development has deepened my understanding of topics in physical science, helped me to teach science by inquiry to my own students, and enabled me to assist my colleagues in implementing inquiry science in their K-5 classrooms. Sponsored by Lillian C. McDermott. 1. A research-based curriculum developed by L.C. McDermott and the Physics Education Group at the University of Washington, Physics by Inquiry, New York, NY, John Wiley & Sons, Inc. (1996.)

Enriching K-12 Science and Mathematics Education Using LEGOs

Science.gov (United States)

Williams, Keeshan; Igel, Irina; Poveda, Ronald; Kapila, Vikram; Iskander, Magued

2012-01-01

This paper presents a series of illustrative LEGO Mindstorms-based science and math activities, developed under an NSF GK-12 Fellows project, for elementary, middle, and high school grades. The activities, developed by engineering and science graduate Fellows in partnership with K-12 teachers, are grade appropriate, address pertinent learning…

6kW class laser cutting equipment; 6kW daishutsuryoku laser setsudanki ni yoru atsuita setsudan

Energy Technology Data Exchange (ETDEWEB)

Nagata, Y.; Nagahori, M. [Tanaka Engineering Works Ltd., Saitama (Japan)

1994-11-01

Application of the laser cutting machine to the area of cutting steel plates of 5 mm thick or more was first enabled in 1990 by the 2 kW oscillator that was introduced in that year. The thick plate cutting industry has a short history. This paper describes the features and performance of the 6 kW laser cutting machine that was announced in April, 1994. The machine uses a newly developed high-speed axial flow type carbon dioxide laser oscillater with the rated output of 6 kW. As the discharge excitation method, the machine adopted the RF (radio frequency) method that causes low contamination in the discharge tube. The 6 kW laser cutting machine has a number of features such as a large cutting area provided by the oscillator contained in the cutting machine, cutting quality stabilized by the optical path length fixing unit, and automatic functions such as automatic setting of the cutting conditions and scheduled operation. The machine can cut mild steel plates of up to 40 mm thick (or up to 16 mm for stainless steel plates) at the cutting speed of 1600 mm/min for a 16 mm thick plate and 2200 mm/min for a 12 mm thick plate, with the good cut sectional surface. 5 figs., 1 tab.

A K Panda

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Panda. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 573-575. Influence of quench rates on the properties of rapidly solidified FeNbCuSiB alloy · A K Panda I Chattoraj S Basu A Mitra · More Details Abstract Fulltext PDF. FeNbCuSiB ...

UNION-K 2.0 User's Manual

International Nuclear Information System (INIS)

Yoo, Jae Woon; Jang, Jin Wook; Kim, Yeong Il

2008-12-01

The unified Input/Output processor UNION-K(UNified Input/Output Processor for Neutronics Analysis by K-CORE) has been developed to provide the automatic input file generation and output processing for the fast reactor core analysis. UNION-K includes the material database for reactor analysis and produces the input files for effective cross section generation, core analysis, and reactivity coefficient calculations. UNION-K can execute corresponding core analysis module and edit core performance parameters from the outputs. UNION-K also provides the graphical interface to check the geometrical arrangement of core and fuel sub-assembly and produces the picture files that can be used for reporting. This report has been prepared for instruction of using UNION-K Ver. 2.0 with examples

Unified Internet Messaging

OpenAIRE

Healy, Paul; Barber, Declan

2015-01-01

As telephony services, mobile services and internet services continue to converge, the prospect of providing Unified Messaging and even Unified Communications becomes increasingly achievable. This paper discusses the growing importance of IP-based networks to Unified Messaging developments and examines some of the key services and protocols that are likely to make Unified Messaging more widely available. In this initial paper, we limit ourselves initially to the unification of text-based mess...

BiteScis: Connecting K-12 teachers with science graduate students to produce lesson plans on modern science research

Science.gov (United States)

Battersby, Cara

2016-01-01

Many students graduate high school having never learned about the process and people behind modern science research. The BiteScis program addresses this gap by providing easily implemented lesson plans that incorporate the whos, whats, and hows of today's scienctific discoveries. We bring together practicing scientists (motivated graduate students from the selective communicating science conference, ComSciCon) with K-12 science teachers to produce, review, and disseminate K-12 lesson plans based on modern science research. These lesson plans vary in topic from environmental science to neurobiology to astrophysics, and involve a range of activities from laboratory exercises to art projects, debates, or group discussion. An integral component of the program is a series of short, "bite-size" articles on modern science research written for K-12 students. The "bite-size" articles and lesson plans will be made freely available online in an easily searchable web interface that includes association with a variety of curriculum standards. This ongoing program is in its first year with about 15 lesson plans produced to date.

Cool Science: K-12 Climate Change Art Displayed on Buses

Science.gov (United States)

Chen, R. F.; Lustick, D. S.; Lohmeier, J.; Thompson, S. R.

2015-12-01

Cool science is an art contest where K12 students create placards (7" x 22") to educate the public about climate change. Students are prompted to create their artwork in response to questions such as: What is the evidence for climate change? How does climate change impact your local community? What can you do to reduce the impacts of climate change? In each of three years, 500-600 student entrees have been submitted from more than 12 school districts across Massachusetts. A panel of judges including scientists, artists, rapid transit representatives, and educators chooses elementary, middle, and high school winners. Winners (6), runners-up (6), and honorable mentions (12) and their families and teachers are invited to an annual Cool Science Award Ceremony to be recognized and view winning artwork. All winning artwork is posted on the Cool Science website. The winning artwork (2 per grade band) is converted into placards (11" x 28") and posters (2.5' x 12') that are placed on the inside (placards) and outside (posters) of buses. Posters are displayed for one month. So far, Cool Science was implemented in Lowell, MA where over 5000 public viewers see the posters daily on the sides of Lowell Rapid Transit Authority (LRTA) buses, making approximately 1,000,000 impressions per year. Cool Science acts to increase climate literacy in children as well as the public, and as such promotes intergenerational learning. Using art in conjunction with science learning about climate change appears to be effective at engaging not just traditionally high achieving science students, but also those interested in the creative arts. Hearing winners' stories about how they created their artwork and what this contest meant to them supports the idea that Cool Science attracts a wide diversity of students. Parents discuss climate change with their children. Multiple press releases announcing the winners further promotes the awareness of climate change throughout school districts and their

The Engaged Microbiologist: Bringing the Microbiological Sciences to the K-12 Community.

Science.gov (United States)

Westenberg, David J

2016-03-01

Exposing K-12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS), "engaging in practices that scientists and engineers actually use." This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM) can play a critical role. ASM encourages its members to engage with the K-12 community by providing networking opportunities and resources for ASM members and K-12 teachers to work together to bring microbiology into the classroom. Journal of Microbiology & Biology Education.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Akshaya K Nayak. Articles written in Journal of Chemical Sciences. Volume 114 Issue 6 December 2002 pp 649-657. Modelling of multifrequency IRMPD for laser isotope separation · Akshaya K Nayak Sisir K Sarkar · More Details Abstract Fulltext PDF. The process of infrared ...

A unified approach to computing real and complex zeros of zero-dimensional ideals

NARCIS (Netherlands)

J.B. Lasserre; M. Laurent (Monique); P. Rostalski; M. Putinar; S. Sullivant

2009-01-01

textabstractIn this paper we propose a unified methodology for computing the set $V_K(I)$ of complex ($K = C$) or real ($K = R$) roots of an ideal $I$ in $R[x]$, assuming $V_K(I)$ is finite. We show how moment matrices, defined in terms of a given set of generators of the ideal I, can be used to

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. D K Lee. Articles written in Journal of Chemical Sciences. Volume 114 Issue 6 December 2002 pp 533-538. Photoinduced electron transfer of chlorophyll in lipid bilayer system · D K Lee K W Seo Y S Kang · More Details Abstract Fulltext PDF. Photoinduced electron transfer ...

Science Communication versus Science Education: The Graduate Student Scientist as a K-12 Classroom Resource

Science.gov (United States)

Strauss, Jeff; Shope, Richard E., III; Terebey, Susan

2005-01-01

Science literacy is a major goal of science educational reform (NRC, 1996; AAAS, 1998; NCLB Act, 2001). Some believe that teaching science only requires pedagogical content knowledge (PCK). Others believe doing science requires knowledge of the methodologies of scientific inquiry (NRC, 1996). With these two mindsets, the challenge for science educators is to create models that bring the two together. The common ground between those who teach science and those who do science is science communication, an interactive process that galvanizes dialogue among scientists, teachers, and learners in a rich ambience of mutual respect and a common, inclusive language of discourse . The dialogue between science and non-science is reflected in the polarization that separates those who do science and those who teach science, especially as it plays out everyday in the science classroom. You may be thinking, why is this important? It is vital because, although not all science learners become scientists, all K-12 students are expected to acquire science literacy, especially with the implementation of the No Child Left Behind Act of 2001 (NCLB). Students are expected to acquire the ability to follow the discourse of science as well as connect the world of science to the context of their everyday life if they plan on moving to the next grade level, and in some states, to graduate from high school. This paper posits that science communication is highly effective in providing the missing link for K-12 students cognition in science and their attainment of science literacy. This paper will focus on the "Science For Our Schools" (SFOS) model implemented at California State Univetsity, Los Angeles (CSULA) as a project of the National Science Foundation s GK-12 program, (NSF 2001) which has been a huge success in bridging the gap between those who "know" science and those who "teach" science. The SFOS model makes clear the distinctions that identify science, science communication, science

Hyperthermal K--TeF6 molecular beam scattering

International Nuclear Information System (INIS)

Wagner, A.F.; Young, C.E.; Pobo, L.G.; Wexler, S.

1982-01-01

Angular distributions of K + product ions from collisions of a beam of hyperthermal K atoms with a cross beam of thermal TeF 6 molecules were determined at 13.7 and 23.7 eV (lab). The angular yields of K atom products from the same system were too low to permit measurement of angular distributions. From the integrated yields, the K + ion/K atom branching ratio was determined to be greater than 10 3 . In addition to the extremely large branching ratio, the differential cross sections exhibited several other unusual characteristics: (a) the lack of small angle scattering, corresponding to virtual absence of covalent scattering, (b) two peaks in the differential cross section with an outer rainbow feature at very large scattering angles (approx.275 eV deg). The observations are unexpected from previous experimental and theoretical studies of electron transfer reactions and from the electronic and structural properties of TeF 6 and TeF - 6 . A simplified dynamics model based on formation of electronically excited TeF - 6 in the initial electron transfer, followed by inner crossings leading to formation of electronically and vibrationally unexcited TeF - 6 or dissociation to TeF - 5 and other ionic products, has been developed which accounts for the experimental results. The model suggests that the observed two peaks in the differential cross section are due to the production of TeF - 6 (inner peak) or TeF - 5 and other ionic dissociation products (outer peak). The model also suggests that the observed branching ratio requires a vertical electron affinity of < or =1.9 eV, much lower than its adiabatic electron affinity of 3.3 eV

Designing Successful Science Contests for K-12

Science.gov (United States)

Schwerin, T.; Colleton, N.

2006-12-01

Contests can engage, motivate, instruct and inspire students of all grade levels and interests. What are the ingredients necessary for a successful science contest? The Institute for Global Environmental Strategies (IGES) has recommendations for designing science-based competitions that are both fun and educational for for elementary and secondary students. These recommendations were developed as a result of IGES' experience gained through two annual student competitions that focus on Earth science topics: An annual art contest, for grades 2-4, challenges U.S. students to explore a specific Earth science topic. For example, past themes have included Polar Explorations: Going to Extremes (2006); Connect-4: Air, Land, Water, and Life (2005); and Picture Me: What Kind of Earth Explorer Would I Be? (2004). The contest supports national science education standards for grades K-4, and includes suggested classroom activities, books, and movies. The Thacher Scholarship was founded in 2000 by IGES in honor of the late Peter S. Thacher, a former IGES board member and leader in promoting the use of satellite remote sensing. The $4,000 scholarship is awarded to exceptional high school students displaying the best use of satellite remote sensing in understanding our changing planet.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K B R Varma. Articles written in Bulletin of Materials Science. Volume 30 Issue 6 December 2007 pp 567-570 Ceramics and Glasses. Microwave synthesis and sintering characteristics of CaCu3Ti4O12 · P Thomas L N Sathapathy K Dwarakanath K B R Varma · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K Prasad. Articles written in Bulletin of Materials Science. Volume 27 Issue 6 December 2004 pp 547-553 Glasses and Ceramics. Impedance analysis of Pb2Sb3LaTi5O18 ceramic · C K Suman K Prasad R N P Choudhary · More Details Abstract Fulltext PDF. Polycrystalline ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. K Vidyasagar. Articles written in Journal of Chemical Sciences. Volume 112 Issue 3 June 2000 pp 417-417. Solid state chemistry of new polysulphides in A/Sn/S (A = Na, K, Rb) systems · M Suseela Devi K Vidyasagar · More Details Fulltext PDF. Volume 115 Issue 5-6 ...

G-factor for the K-6, Jsup(π) = 6+ isomer in 178Hf

International Nuclear Information System (INIS)

Faestermann, T.; Haeusser, O.; Ward, D.; Andrews, H.R.; Alexander, T.K.; Horn, D.

1978-01-01

High-K isomers are prevalent towards the end of the rare-earth region of deformed nuclei where the valence particles fill high Ω orbitals. Very little is known about the g-factors for these isomers mainly because in the half-life range encountered, 50 ns-50 μs, quadrupole and paramagnetic relaxation effects can destroy the nuclear alignment very rapidly. In 178 Hf a Isub(π)K=6 + 6 isomer with a half-life of 78 ns has recently been found. It decays predominantly to the ground band (K=O) 6 + and 4 + levels with gamma rays of 921.8 keV and 1247.3 keV respectively. The authors have measured the g-factor of this isomer with the method of perturbed angular distributions. (Auth.)

Unified microprocessor CAMAC module for preliminary data processing

International Nuclear Information System (INIS)

Zaushitsin, V.L.; Kulik, O.V.; Repin, V.M.

1984-01-01

The UP-80 unified active module is described. It is made in the CAMAC standard on the base of the K580IK80 microprocessor allowing to increase the rate of large-volume experimental spectroscopic data processing by an order. Loading of 5 different programs for data processing is possible. Data from the operative storage with 1K capacity (8 bits) are recorded and read out trhough the CAMAC line (the regime of unit exchange is possible) or through the joint of the external line

NGSS-Aligned, K-12 Climate Science Curricula, taught with citizen science and teacher-led inquiry methods

Science.gov (United States)

Zainfeld, S.

2017-12-01

Teacher-led inquiry into student learning is a promising method of formative assessment to gain insight into student achievement. NGSS-aligned K-12 Climate Science curricula taught with citizen science and teacher-led inquiry methods are described, along with results from a scientist-teacher collaboration survey.

Outstanding Science Trade Books for Students K-12: Books Published in 2015

Science.gov (United States)

Science and Children, 2016

2016-01-01

Science teachers and mentors continue to be challenged to meet the high expectations of "A Framework for K-12 Science Education" and the "Next Generation Science Standards" ("NGSS"). Indeed the "Framework" urges to help learners "[build] progressively more sophisticated explanations of natural…

X-ray diffraction studies on K3Gd5 (PO4) 6 between 20K to 1073 K

International Nuclear Information System (INIS)

Bevara, Samatha; Achary, S.N.; Tyagi, A.K.; Sinha, A.K.; Sastry, P.U.

2016-01-01

Complex inorganic phosphates have been of interest due to their diversified crystal chemistry depending on composition, preparation condition as well as external parameters like temperature and pressure. In addition varieties of complex phosphates have been considered as potential host matrices for immobilization of radioactive elements as well as for selective separation of ions from high level nuclear waste or heavy metal ion pollutants from environment. Temperature and/or pressure induced structural variations are often noticed in such type complex phosphates. In K 2 O-Gd 2 O 3 -P 2 O 5 , a novel complex phosphate with K 3 Gd 5 (PO 4 ) 6 has been reported recently. In order to study the effect of temperature on crystal structure of K 3 Gd 5 (PO 4 ) 6 variable temperature XRD studies between 20 K to 1073 K were carried out and the results are presented herein

Association between PI3K/Akt/mTOR/p70S6K signaling pathway and hepatic fibrosis

Directory of Open Access Journals (Sweden)

WU Changhui

2015-11-01

Full Text Available Phosphoinositide 3-kinase (PI3K/protein kinase-B (AkT/mammalian target of rapamycin (mTOR/70-kDa ribosomal protein S6 kinase (p70S6K, PI3K/Akt/mTOR/p70S6K, is an important signaling pathway in the life activities of cells, and it plays an important role in promoting the growth, proliferation, invasion, and anti-apoptosis of cells and promoting angiogenesis. It was clarified that the PI3K/Akt/mTOR/p70S6K signaling pathway is involved in regulating the activities of hepatic stellate cell(HSC, thus influencing the development and progression of hepatic fibrosis. Analysis demonstrated that blocking any target of the PI3K/Akt/mTOR/p70S6K signaling pathway can inhibit the activation and proliferation of HSC, promote the apoptosis of HSC, inhibit the extracellular matrix secretion from HSC, and delay the progression of hepatic fibrosis. Blocking the pathway is expected to be a treatment strategy for hepatic fibrosis.

That's How We Roll: The NASA K2 Mission Science Products and Their Performance Metrics

Science.gov (United States)

Van Cleve, Jeffrey E.; Howell, Steve B.; Smith, Jeffrey C.; Clarke, Bruce D.; Thompson, Susan E.; Bryson, Stephen T.; Lund, Mikkel N.; Handberg, Rasmus; Chaplin, William J.

2016-07-01

NASA's exoplanet Discovery mission Kepler was reconstituted as the K2 mission a year after the failure of the second of Kepler's four reaction wheels in 2013 May. Fine control of the spacecraft pointing is now accomplished through the use of the two remaining well-functioning reaction wheels and balancing the pressure of sunlight on the solar panels, which constrains K2 observations to fields in the ecliptic for up to approximately 80 days each. This pseudo-stable mechanism gives typical roll motion in the focal plane of 1.0 pixels peak-to-peak over 6 hr at the edges of the field, two orders of magnitude greater than typical 6 hr pointing errors in the Kepler primary mission. Despite these roll errors, the joint performance of the flight system and its modified science data processing pipeline restores much of the photometric precision of the primary mission while viewing a wide variety of targets, thus turning adversity into diversity. We define K2 performance metrics for data compression and pixel budget available in each campaign; the photometric noise on exoplanet transit and stellar activity timescales; residual correlations in corrected long-cadence light curves; and the protection of test sinusoidal signals from overfitting in the systematic error removal process. We find that data compression and noise both increase linearly with radial distance from the center of the field of view, with the data compression proportional to star count as well. At the center, where roll motion is nearly negligible, the limiting 6 hr photometric precision for a quiet 12th magnitude star can be as low as 30 ppm, only 25% higher than that of Kepler. This noise performance is achieved without sacrificing signal fidelity; test sinusoids injected into the data are attenuated by less than 10% for signals with periods upto 15 days, so that a wide range of stellar rotation and variability signatures are preserved by the K2 pipeline. At timescales relevant to asteroseismology, light

Unified theory in the worldline approach

Directory of Open Access Journals (Sweden)

James P. Edwards

2015-11-01

Full Text Available We explore unified field theories based on the gauge groups SU(5 and SO(10 using the worldline approach for chiral fermions with a Wilson loop coupling to a background gauge field. Representing path ordering and chiral projection operators with functional integrals has previously reproduced the sum over the chiralities and representations of standard model particles in a compact way. This paper shows that for SU(5 the 5¯ and 10 representations – into which the Georgi–Glashow model places the left-handed fermionic content of the standard model – appear naturally and with the familiar chirality. We carry out the same analysis for flipped SU(5 and uncover a link to SO(10 unified theory. We pursue this by exploring the SO(10 theory in the same framework, the less established unified theory based on SU(6 and briefly consider the Pati–Salam model using SU(4×SU(2×SU(2.

UNION-K 2.0 User's Manual

Energy Technology Data Exchange (ETDEWEB)

Yoo, Jae Woon; Jang, Jin Wook; Kim, Yeong Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-12-15

The unified Input/Output processor UNION-K(UNified Input/Output Processor for Neutronics Analysis by K-CORE) has been developed to provide the automatic input file generation and output processing for the fast reactor core analysis. UNION-K includes the material database for reactor analysis and produces the input files for effective cross section generation, core analysis, and reactivity coefficient calculations. UNION-K can execute corresponding core analysis module and edit core performance parameters from the outputs. UNION-K also provides the graphical interface to check the geometrical arrangement of core and fuel sub-assembly and produces the picture files that can be used for reporting. This report has been prepared for instruction of using UNION-K Ver. 2.0 with examples.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. A S Laxmi Prasad. Articles written in Journal of Earth System Science. Volume 114 Issue 6 December 2005 pp 725-731. Lunar ranging instrument for Chandrayaan-1 · J A Kamalakar K V S Bhaskar A S Laxmi Prasad R Ranjith K A Lohar R Venketeswaran T K Alex.

Unified description of ^{6}Li structure and deuterium-^{4}He dynamics with chiral two- and three-nucleon forces.

Science.gov (United States)

Hupin, Guillaume; Quaglioni, Sofia; Navrátil, Petr

2015-05-29

We provide a unified ab initio description of the ^{6}Li ground state and elastic scattering of deuterium (d) on ^{4}He (α) using two- and three-nucleon forces from chiral effective field theory. We analyze the influence of the three-nucleon force and reveal the role of continuum degrees of freedom in shaping the low-lying spectrum of ^{6}Li. The calculation reproduces the empirical binding energy of ^{6}Li, yielding an asymptotic D- to S-state ratio of the ^{6}Li wave function in the d+α configuration of -0.027, in agreement with a determination from ^{6}Li-^{4}He elastic scattering, but overestimates the excitation energy of the 3^{+} state by 350 keV. The bulk of the computed differential cross section is in good agreement with data. These results endorse the application of the present approach to the evaluation of the ^{2}H(α,γ)^{6}Li radiative capture, responsible for the big-bang nucleosynthesis of ^{6}Li.

Teaching Planetary Sciences in Bilingual Classrooms

Science.gov (United States)

Lebofsky, L. A.; Lebofsky, N. R.

1993-05-01

Planetary sciences can be used to introduce students to the natural world which is a part of their lives. Even children in an urban environment are aware of such phenomena as day and night, shadows, and the seasons. It is a science that transcends cultures, has been prominent in the news in recent years, and can generate excitement in young minds as no other science can. It also provides a useful tool for understanding other sciences and mathematics, and for developing problem solving skills which are important in our technological world. However, only 15 percent of elementary school teachers feel very well qualified to teach earth/space science, while better than 80% feel well qualified to teach reading; many teachers avoid teaching science; very little time is actually spent teaching science in the elementary school: 19 minutes per day in K--3 and 38 minutes per day in 4--6. While very little science is taught in elementary and middle school, earth/space science is taught at the elementary level in less than half of the states. Therefore in order to teach earth/space science to our youth, we must empower our teachers, making them familiar and comfortable with existing materials. Tucson has another, but not unique, problem. The largest public school district, the Tucson Unified School District (TUSD), provides a neighborhood school system enhanced with magnet, bilingual and special needs schools for a school population of 57,000 students that is 4.1% Native American, 6.0% Black, and 36.0% Hispanic (1991). This makes TUSD and the other school districts in and around Tucson ideal for a program that reaches students of diverse ethnic backgrounds. However, few space sciences materials exist in Spanish; most materials could not be used effectively in the classroom. To address this issue, we have translated NASA materials into Spanish and are conducting a series of workshops for bilingual classroom teachers. We will discuss in detail our bilingual classroom workshops

ACHP | Unified Federal Review

Science.gov (United States)

Search skip specific nav links Home arrow Unified Federal Review Three logos: 1) Executive Office of the Homeland Security. Unified Federal Environmental and Historic Preservation Review Process Please visit the new location for the Unified Federal Review located here: http://www.fema.gov/environmental-historic

A Primary Grade (K-3) Earth Science Program

Science.gov (United States)

Schwartz, Maurice L.; Slesnick, Irwin L.

1973-01-01

Describes the rationale and structure of a newly developed earth science program for elementary school children (K-3). The activities involve pre-operational and concrete operational stages, progressing from one to the other. Children show sustained interest and enthusiasm as they investigate landforms, the moon, fossils, and weather phenomena.…

A unified free-form representation applied to the shape optimization of the hohlraum with octahedral 6 laser entrance holes

International Nuclear Information System (INIS)

Jiang, Shaoen; Ding, Yongkun; Huang, Yunbao; Li, Haiyan; Jing, Longfei; Huang, Tianxuan

2016-01-01

The hohlraum is very crucial for indirect laser driven Inertial Confinement Fusion. Usually, its shape is designed as sphere, cylinder, or rugby with some kind of fixed functions, such as ellipse or parabola. Recently, a spherical hohlraum with octahedral 6 laser entrance holes (LEHs) has been presented with high flux symmetry [Lan et al., Phys. Plasmas 21, 010704 (2014); 21, 052704 (2014)]. However, there is only one shape parameter, i.e., the hohlraum to capsule radius ratio, being optimized. In this paper, we build the hohlraum with octahedral 6LEHs with a unified free-form representation, in which, by varying additional shape parameters: (1) available hohlraum shapes can be uniformly and accurately represented, (2) it can be used to understand why the spherical hohlraum has higher flux symmetry, (3) it allows us to obtain a feasible shape design field satisfying flux symmetry constraints, and (4) a synthetically optimized hohlraum can be obtained with a tradeoff of flux symmetry and other hohlraum performance. Finally, the hohlraum with octahedral 6LEHs is modeled, analyzed, and then optimized based on the unified free-form representation. The results show that a feasible shape design field with flux asymmetry no more than 1% can be obtained, and over the feasible design field, the spherical hohlraum is validated to have the highest flux symmetry, and a synthetically optimal hohlraum can be found with closing flux symmetry but larger volume between laser spots and centrally located capsule

A unified free-form representation applied to the shape optimization of the hohlraum with octahedral 6 laser entrance holes

Energy Technology Data Exchange (ETDEWEB)

Jiang, Shaoen; Ding, Yongkun [Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Center for Applied Physics and Technology, Peking University, Beijing 100871 (China); Huang, Yunbao, E-mail: Huangyblhy@gmail.com, E-mail: scmyking-2008@163.com; Li, Haiyan [Key Laboratory of Computer Integrated Manufacturing System, Guangdong University of Technology, Guangzhou 510006 (China); Jing, Longfei, E-mail: Huangyblhy@gmail.com, E-mail: scmyking-2008@163.com; Huang, Tianxuan [Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China)

2016-01-15

The hohlraum is very crucial for indirect laser driven Inertial Confinement Fusion. Usually, its shape is designed as sphere, cylinder, or rugby with some kind of fixed functions, such as ellipse or parabola. Recently, a spherical hohlraum with octahedral 6 laser entrance holes (LEHs) has been presented with high flux symmetry [Lan et al., Phys. Plasmas 21, 010704 (2014); 21, 052704 (2014)]. However, there is only one shape parameter, i.e., the hohlraum to capsule radius ratio, being optimized. In this paper, we build the hohlraum with octahedral 6LEHs with a unified free-form representation, in which, by varying additional shape parameters: (1) available hohlraum shapes can be uniformly and accurately represented, (2) it can be used to understand why the spherical hohlraum has higher flux symmetry, (3) it allows us to obtain a feasible shape design field satisfying flux symmetry constraints, and (4) a synthetically optimized hohlraum can be obtained with a tradeoff of flux symmetry and other hohlraum performance. Finally, the hohlraum with octahedral 6LEHs is modeled, analyzed, and then optimized based on the unified free-form representation. The results show that a feasible shape design field with flux asymmetry no more than 1% can be obtained, and over the feasible design field, the spherical hohlraum is validated to have the highest flux symmetry, and a synthetically optimal hohlraum can be found with closing flux symmetry but larger volume between laser spots and centrally located capsule.

The short-circuit test results of 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer

International Nuclear Information System (INIS)

Tomioka, A.; Otonari, T.; Ogata, T.; Iwakuma, M.; Okamoto, H.; Hayashi, H.; Iijima, Y.; Saito, T.; Gosho, Y.; Tanabe, K.; Izumi, T.; Shiohara, Y.

2011-01-01

The 6.9 kV/2.3 kV 400 kVA-class single-phase YBCO model transformer with the YBCO tape with copper tape was manufactured for short-circuit current test. Short-circuit test was performed and the short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. The transformer withstood short-circuit current. We are planning to turn the result into a consideration of a 66 kV/6.9 kV-20 MVA-class three-phase superconducting transformer. We are developing an elemental technology for 66 kV/6.9 kV 20 MVA-class power transformer with YBCO conductors. The protection of short-circuit technology is one of the elemental technologies for HTS transformer. Since short-circuit current is much higher than critical current of YBCO tape, there is a possibility that superconducting characteristics may be damaged during short-circuit period. We made a conductor to compose the YBCO tape with copper tape. We manufactured 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer using this conductor and performed short-circuit current test. The short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. We may consider this conductor withstands short-circuit current.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Swapan K Pati. Articles written in Journal of Chemical Sciences. Volume 115 Issue 5-6 October-December 2003 pp 533-542. Electrostatic potential profile and nonlinear current in an interacting one-dimensional molecular wire · S Lakshmi Swapan K Pati · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Anjum Qureshi. Articles written in Bulletin of Materials Science. Volume 29 Issue 6 November 2006 pp 605-609. Analysis of organometallics dispersed polymer composite irradiated with oxygen ions · N L Singh Anjum Qureshi A K Rakshit D K Avasthi · More Details Abstract ...

Career education attitudes and practices of K-12 science educators

Science.gov (United States)

Smith, Walter S.

A random sample of 400 K-12 science educators who were members of the National Science Teachers Association were surveyed regarding their attitude toward and practice of career education in their science teaching. These science teachers rejected a narrowly vocational view, favoring instead a conception of career education which included self-perception, values analysis, and vocational skills objectives. The science educators affirmed the importance of career education for a student's education, asserted career education ought to be taught in their existing science courses, and expressed a willingness to do so. Fewer than one-third of the science teachers, however, reported incorporating career education at least on a weekly basis in their science lessons. The major impediment to including more career education in science teaching was seen to be their lack of knowledge of methods and materials relevant to science career education, rather than objections from students, parents, or administrators; their unwillingness; or their evaluation of career education as unimportant. Thus, in order to improve this aspect of science teaching, science teachers need more concrete information about science career education applications.

A phenomenological case study concerning science teacher educators' beliefs and teaching practices about culturally relevant pedagogy and preparing K-12 science teachers to engage African American students in K-12 science

Science.gov (United States)

Underwood, Janice Bell

Due to the rising diversity in today's schools, science teacher educators (STEs) suggest that K-12 teachers must be uniquely prepared to engage these students in science classrooms. Yet, in light of the increasing white-black science achievement gap, it is unclear how STEs prepare preservice teachers to engage diverse students, and African Americans in particular. Therefore, the purpose of this study was to find out how STEs prepare preservice teachers to engage African American students in K-12 science. Thus, using the culturally relevant pedagogy (CRP) framework, this phenomenological case study explored beliefs about culturally relevant science teaching and the influence of reported beliefs and experiences related to race on STEs' teaching practices. In the first phase, STE's in a mid-Atlantic state were invited to participate in an electronic survey. In the second phase, four participants, who were identified as exemplars, were selected from the survey to participate in three semi-structured interviews. The data revealed that STEs were more familiar with culturally responsive pedagogy (CResP) in the context of their post-secondary classrooms as opposed to CRP. Further, most of the participants in part one and two described modeling conventional ways they prepare their preservice teachers to engage K-12 students, who represent all types of diversity, without singling out any specific race. Lastly, many of the STEs' in this study reported formative experiences related to race and beliefs in various manifestations of racism have impacted their teaching beliefs and practices. The findings of this study suggest STEs do not have a genuine understanding of the differences between CRP and CResP and by in large embrace CResP principles. Secondly, in regards to preparing preservice teachers to engage African American students in science, the participants in this study seemed to articulate the need for ideological change, but were unable to demonstrate pedagogical changes

J K Thomas

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. J K Thomas. Articles written in Bulletin of Materials Science. Volume 31 Issue 5 October 2008 pp 719-722 Nanomaterials. Synthesis, characterization, sintering and dielectric properties of nanostructured perovskite-type oxide, Ba2GdSbO6 · C Vijayakumar H Padma Kumar Sam ...

Reading, Writing & Rings: Science Literacy for K-4 Students

Science.gov (United States)

McConnell, S.; Spilker, L.; Zimmerman-Brachman, R.

2007-12-01

Scientific discovery is the impetus for the K-4 Education program, "Reading, Writing & Rings." This program is unique because its focus is to engage elementary students in reading and writing to strengthen these basic academic skills through scientific content. As science has been increasingly overtaken by the language arts in elementary classrooms, the Cassini Education Program has taken advantage of a new cross-disciplinary approach to use language arts as a vehicle for increasing scientific content in the classroom. By utilizing the planet Saturn and the Cassini-Huygens mission as a model in both primary reading and writing students in these grade levels, young students can explore science material while at the same time learning these basic academic skills. Content includes reading, thinking, and hands-on activities. Developed in partnership with the Cassini-Huygens Education and Public Outreach Program, the Bay Area Writing Project/California Writing Project, Foundations in Reading Through Science & Technology (FIRST), and the Caltech Pre-College Science Initiative (CAPSI), and classroom educators, "Reading, Writing & Rings" blends the excitement of space exploration with reading and writing. All materials are teacher developed, aligned with national science and language education standards, and are available from the Cassini-Huygens website: http://saturn.jpl.nasa.gov/education/edu-k4.cfm Materials are divided into two grade level units. One unit is designed for students in grades 1 and 2 while the other unit focuses on students in grades 3 and 4. Each includes a series of lessons that take students on a path of exploration of Saturn using reading and writing prompts.

The Unified English Braille Code: Examination by Science, Mathematics, and Computer Science Technical Expert Braille Readers

Science.gov (United States)

Holbrook, M. Cay; MacCuspie, P. Ann

2010-01-01

Braille-reading mathematicians, scientists, and computer scientists were asked to examine the usability of the Unified English Braille Code (UEB) for technical materials. They had little knowledge of the code prior to the study. The research included two reading tasks, a short tutorial about UEB, and a focus group. The results indicated that the…

Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282: Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics

Directory of Open Access Journals (Sweden)

Filip Zemek

2013-08-01

Full Text Available Acetylcholinesterase (AChE reactivators (oximes are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE, critical detoxification enzymes in the blood and in the central nervous system (CNS. After exposure to OPNAs, accumulation of acetylcholine (ACh overstimulates receptors and blocks neuromuscular junction transmission resulting in CNS toxicity. Current efforts at treatments for OPNA exposure are focused on non-quaternary reactivators, monoisonitrosoacetone oximes (MINA, and diacylmonoxime reactivators (DAM. However, so far only quaternary oximes have been approved for use in cases of OPNA intoxication. Five acetylcholinesterase reactivator candidates (K027, K075, K127, K203, K282 are presented here, together with pharmacokinetic data (plasma concentration, human serum albumin binding potency. Pharmacokinetic curves based on intramuscular application of the tested compounds are given, with binding information and an evaluation of structural relationships. Human Serum Albumin (HSA binding studies have not yet been performed on any acetylcholinesterase reactivators, and correlations between structure, concentration curves and binding are vital for further development. HSA bindings of the tested compounds were 1% (HI-6, 7% (obidoxime, 6% (trimedoxime, and 5%, 10%, 4%, 15%, and 12% for K027, K075, K127, K203, and K282, respectively.

jijimon k thomas

Indian Academy of Sciences (India)

JIJIMON K THOMAS. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1171-1178. Enhanced infrared transmission characteristics of microwave-sintered Y$_2$O$_3$–MgO nanocomposite · C T MATHEW SAM SOLOMON JACOB KOSHY JIJIMON K THOMAS · More Details Abstract ...

Acinetobacter baumannii K11 and K83 capsular polysaccharides have the same 6-deoxy-l-talose-containing pentasaccharide K units but different linkages between the K units.

Science.gov (United States)

Kenyon, Johanna J; Shashkov, Alexander S; Senchenkova, Sof'ya N; Shneider, Mikhail M; Liu, Bin; Popova, Anastasiya V; Arbatsky, Nikolay P; Miroshnikov, Konstantin A; Wang, Lei; Knirel, Yuriy A; Hall, Ruth M

2017-10-01

Acinetobacter baumannii produces a variety of capsular polysaccharides (CPS) via genes located at the chromosomal K locus and some KL gene clusters include genes for the synthesis of specific sugars. The structures of K11 and K83 CPS produced by isolates LUH5545 and LUH5538, which carry related KL11a and KL83 gene clusters, respectively, were established by sugar analysis and one- and two-dimensional 1 H and 13 C NMR spectroscopy. Both CPS contain l-rhamnose (l-Rha) and 6-deoxy-l-talose (l-6dTal), and both KL gene clusters include genes for dTDP-l-Rhap synthesis and a tle (talose epimerase) gene encoding an epimerase that converts dTDP-l-Rhap to dTDP-l-6dTalp. The K11 and K83 repeat units are the same pentasaccharide, consisting of d-glucose, l-Rha, l-6dTal, and N-acetyl-d-glucosamine, except that l-6dTal is 2-O-acetylated in K83. However, the K units are linked differently, with l-Rha in the main chain in K11, but as a side-branch in K83. KL11 and KL83 encode unrelated Wzy polymerases that link the K units together and different acetyltransferases, though only Atr8 from KL83 is active. The substrate specificity of each Wzy polymerase was assigned, and the functions of all glycosyltransferases were predicted. The CPS structures produced by three closely related K loci, KL29, KL105 and KL106, were also predicted. Copyright © 2017 Elsevier B.V. All rights reserved.

Development of 66 kV/6.9 kV 2 MV A prototype HTS power transformer

International Nuclear Information System (INIS)

Bohno, T.; Tomioka, A.; Imaizumi, M.; Sanuki, Y.; Yamamoto, T.; Yasukawa, Y.; Ono, H.; Yagi, Y.; Iwadate, K.

2005-01-01

We have developed the technology of the producing a HTS magnet for the power transformer. Three subjects have been mainly studied, high voltage technologies, large current and low AC loss technologies and sub-cooling system technologies to establish the technology of 66 kV/6.9 kV 10 MV A class HTS power transformer. In order to verify the validity of elemental technologies, such as high voltage technologies, large current and low AC loss technologies and sub-cooling system technologies, single-phase 2 MV A class 66 kV/6.9 kV prototype HTS transformer was manufactured and tested. In the load loss (AC loss) measurement, it was obtained that the measured value of 633 W was almost corresponding to the calculated value of 576 W at the rated operation of 2 MV A. Moreover, the breakdown was not found all voltage withstand test. These test results indicate that elemental technologies were established for the development of 66 kV/6.9 kV 10 MV A class HTS power transformer

Can the laws of physics be unified ?

CERN Document Server

Langacker, Paul

2017-01-01

The standard model of particle physics describes our current understanding of nature's fundamental particles and their interactions, yet gaps remain. For example, it does not include a quantum theory of gravity, nor does it explain the existence of dark matter. Once complete, however, the standard model could provide a unified description of the very building blocks of the universe. Researchers have been chasing this dream for decades, and many wonder whether such a dream can ever be made a reality. Can the Laws of Physics Be Unified? is a short introduction to this exciting frontier of physics. The book is accessibly written for students and researchers across the sciences, and for scientifically minded general readers. Paul Langacker begins with an overview of the key breakthroughs that have shaped the standard model, and then describes the fundamental particles, their interactions, and their role in cosmology. He goes on to explain field theory, internal symmetries, Yang-Mills theories, strong and electro...

A unified survival theory of the functioning of the hypocretinergic system.

Science.gov (United States)

Chase, Michael H

2013-10-01

This article advances the theory that the hypocretinergic (orexinergic) system initiates, coordinates, and maintains survival behaviors and survival-related processes (i.e., the Unified Survival Theory of the Functioning of the Hypocretinergic System or "Unified Hypocretinergic Survival Theory"). A priori presumptive support for the Unified Hypocretinergic Survival Theory emanates from the fact that neurons that contain hypocretin are located in the key executive central nervous system (CNS) site, the lateral hypothalamus, that for decades has been well-documented to govern core survival behaviors such as fight, flight, and food consumption. In addition, the hypocretinergic system exhibits the requisite morphological and electrophysiological capabilities to control survival behaviors and related processes. Complementary behavioral data demonstrate that all facets of "survival" are coordinated by the hypocretinergic system and that hypocretinergic directives are not promulgated except during survival behaviors. Importantly, it has been shown that survival behaviors are selectively impacted when the hypocretinergic system is impaired or rendered nonfunctional, whereas other behaviors are relatively unaffected. The Unified Hypocretinergic Survival Theory resolves the disparate, perplexing, and often paradoxical-appearing results of previous studies; it also provides a foundation for future hypothesis-driven basic science and clinical explorations of the hypocretinergic system.

A model unified field equation

International Nuclear Information System (INIS)

Perring, J.K.; Skyrme, T.H.R.

1994-01-01

The classical solutions of a unified field theory in a two-dimensional space-time are considered. This system, a model of a interacting mesons and baryons, illustrates how the particle can be built from a wave-packet of mesons and how reciprocally the meson appears as a tightly bound combination of particle and antiparticle. (author). 6 refs

First-light instrument for the 3.6-m Devasthal Optical Telescope: 4Kx4K CCD Imager

Science.gov (United States)

Pandey, Shashi Bhushan; Yadav, Rama Kant Singh; Nanjappa, Nandish; Yadav, Shobhit; Reddy, Bheemireddy Krishna; Sahu, Sanjit; Srinivasan, Ramaiyengar

2018-04-01

As a part of in-house instrument developmental activity at ARIES, the 4Kx4K CCD Imager is designed and developed as a first-light instrument for the axial port of the 3.6-m Devasthal Optical Telescope (DOT). The f/9 beam of the telescope having a plate-scale of 6.4"/mm is utilized to conduct deeper photom-etry within the central 10' field of view. The pixel size of the blue-enhanced liquid nitrogen cooled STA4150 4Kx4K CCD chip is 15 μm, with options to select gain and speed values to utilize the dynamic range. Using the Imager, it is planned to image the central 6.5'x6.5' field of view of the telescope for various science goals by getting deeper images in several broad-band filters for point sources and objects with low surface brightness. The fully assembled Imager along with automated filter wheels having Bessel UBV RI and SDSS ugriz filters was tested in late 2015 at the axial port of the 3.6-m DOT. This instrument was finally mounted at the axial port of the 3.6-m DOT on 30 March 2016 when the telescope was technically activated jointly by the Prime Ministers of India and Belgium. It is expected to serve as a general purpose multi-band deep imaging instrument for a variety of science goals including studies of cosmic transients, active galaxies, star clusters and optical monitoring of X-ray sources discovered by the newly launched Indian space-mission called ASTROSAT, and follow-up of radio bright objects discovered by the Giant Meterwave Radio Telescope.

Sample environment for neutron scattering measurements of internal stresses in engineering materials in the temperature range of 6 K to 300 K.

Science.gov (United States)

Kirichek, O; Timms, J D; Kelleher, J F; Down, R B E; Offer, C D; Kabra, S; Zhang, S Y

2017-02-01

Internal stresses in materials have a considerable effect on material properties including strength, fracture toughness, and fatigue resistance. The ENGIN-X beamline is an engineering science facility at ISIS optimized for the measurement of strain and stress using the atomic lattice planes as a strain gauge. Nowadays, the rapidly rising interest in the mechanical properties of engineering materials at low temperatures has been stimulated by the dynamic development of the cryogenic industry and the advanced applications of the superconductor technology. Here we present the design and discuss the test results of a new cryogenic sample environment system for neutron scattering measurements of internal stresses in engineering materials under a load of up to 100 kN and in the temperature range of 6 K to 300 K. Complete cooling of the system starting from the room temperature down to the base temperature takes around 90 min. Understanding of internal stresses in engineering materials at cryogenic temperatures is vital for the modelling and designing of cutting-edge superconducting magnets and other superconductor based applications.

a k ganguli

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K GANGULI. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1121-1125. High-pressure studies of superconductivity in BiO 0.75 F 0.25 BiS 2 · ZEBA HAQUE GOHIL S THAKUR GANESAN KALAI SELVAN SONACHALAM ARUMUGAM L C ...

Assessing the Life Science Knowledge of Students and Teachers Represented by the K-8 National Science Standards

Science.gov (United States)

Sadler, Philip M.; Coyle, Harold; Cook Smith, Nancy; Miller, Jaimie; Mintzes, Joel; Tanner, Kimberly; Murray, John

2013-01-01

We report on the development of an item test bank and associated instruments based on the National Research Council (NRC) K-8 life sciences content standards. Utilizing hundreds of studies in the science education research literature on student misconceptions, we constructed 476 unique multiple-choice items that measure the degree to which test…

Development of 6.6 kV/600 A superconducting fault current limiter using coated conductors

Energy Technology Data Exchange (ETDEWEB)

Yazawa, T., E-mail: takashi.yazawa@toshiba.co.j [Toshiba Corporation, Power Systems Company (Japan); Koyanagi, K.; Takahashi, M.; Toba, K.; Takigami, H.; Urata, M. [Toshiba Corporation, Power Systems Company (Japan); Iijima, Y.; Saitoh, T. [Fujikura Ltd. (Japan); Amemiya, N. [Superconductivity Research Laboratory, ISTEC (Japan); Shiohara, Y. [Department of Electrical Engineering, Kyoto University (Japan); Ito, T. [Tokyo Gas Co., Ltd. (Japan)

2009-10-15

As one of the programs in the Ministry of Economy, Trade and Industry (METI) project regarding R and D on superconducting coated conductor, three-phase superconducting fault current limiter (SFCL) for 6.6 kV application was developed and successfully tested. The developed SFCL was mainly comprised three-phase set of current limiting coils installed in a sub-cooled nitrogen cryostat with a GM cryocooler, circuit breakers and a sequence circuit. The whole system was installed in a cubicle. Two tapes of coated conductor were wound in parallel in each coil to obtain the rated current of 72 A rms. After developing the whole SFCL system, short circuit experiments were implemented with a short circuit generator. In a three-line ground fault test, the SFCL successfully restricted the prospected short circuit current over 1.6 kA to about 800 A by the applied voltage of 6.6 kV. The SFCL was installed in a user field and connected with a gas engine generator, followed by a consecutive operation. In this program, 600 A class FCL coil, with which four coated conductor tapes were wound, was also developed. The coil showed sufficiently low AC loss at the rated current. With these results, the program attained the planned target of the fundamentals for the 6.6 kV/600 A SFCL.

Radial and Regge excitations in unified, grand unified and subconstituent models

International Nuclear Information System (INIS)

Schnitzer, H.J.

1981-01-01

Necessary group theoretic conditions for all elementary gauge bosons and fermions of an arbitrary renormalizable gauge theory to lie on Regge trajectories are reviewed. It is then argued that in properly unified gauge theories all particles of a given spin lie on Regge trajectories. This then implies that a properly unified gauge theory has no local U(1) factor groups, and no massive fermion singlets. A consideration of the general pattern of Regge and radial recurrences to be expected in quantum field theories suggests that the presence or absence of spin 3/2 quarks and/or leptons in the TeV region will provide crucial clues to enable one to distinguish between various classes of unified, grand unified, and subconstituent models. The correct interpretation of such excited fermions will require correlation with the higgs boson mass and possible radial and Regge excitations of the weak vector bosons. (orig.)

Piezoelectric ceramic material, containing PbNb2O6, K2Nb2O6

International Nuclear Information System (INIS)

Fesenko, E.G.; Filip'ev, V.S.; Razumovskaya, O.N.; Cherner, Ya.E.; Rudkovskaya, L.M.; Zav'yalov, V.P.; Molchanova, R.A.; Kryshtop, V.G.; Panich, A.E.; Servuli, V.A.

1984-01-01

A new piezoelectric ceramic material including PbNb 2 O 6 , K 2 Nb 2 O 6 is prepared. Above the new material contains Nb 2 O 5 . The invention relates to piezotechnique. The principal advantage of this material for acoustic converters is high anisotropy of piezoelectric properties as well as high Curie temperature (T C =539-553 deg C). The composition containing 93.96 mole% PbNb 2 O 6 ; 2.48 mole% K 2 Nb 2 O 6 and 3.56 mole% Nb 2 O 5 has optimum content of parameters

p k chakrabarti

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. P K CHAKRABARTI. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 60. Magnetic measurements, Raman and infrared spectra of metal–ligand complex derived from CoCl 2 · 6H 2 O and 2-benzoyl pyridine · S DATTA A S MAHAPATRA P SETT2 ...

p k mallick

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. P K MALLICK. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 60. Magnetic measurements, Raman and infrared spectra of metal–ligand complex derived from CoCl 2 · 6H 2 O and 2-benzoyl pyridine · S DATTA A S MAHAPATRA P SETT2, ...

The Unified Theory of Physics

OpenAIRE

Chung, Ding-Yu

2002-01-01

The unified theory of physics unifies various phenomena in our observable universe and other universes. The unified theory is based on the zero-energy universe and the space-object structures. Different universes in different developmental stages are the different expressions of the space-object structures. The unified theory is divided into five parts: the space-object structures, cosmology, the periodic table of elementary particles, the galaxy formation, and the extreme force field. The sp...

Two structure types based on Si6O15 rings: synthesis and structural and spectroscopic characterisation of Cs1.86K1.14DySi6O15 and Cs1.6K1.4SmSi6O15

International Nuclear Information System (INIS)

Wierzbicka-Wieczorek, Maria; Goeckeritz, Martin; Kolitsch, Uwe; Lenz, Christoph; Giester, Gerald

2015-01-01

The silicate Cs 1.86 K 1.14 DySi 6 O 15 represents a mixed tetrahedral-octahedral framework structure type based on roughly circular Si 6 O 15 rings and isolated DyO 6 octahedra. The silicate Cs 1.6 K 1.4 SmSi 6 O 15 has a layered atomic arrangement built from corrugated Si 6 O 15 layers containing four-, six- and eight-membered rings. The layers are connected by isolated SmO 6 octahedra to form a mixed tetrahedral-octahedral framework. This structure shows a close structural relationship to β-K 3 NdSi 6 O 15 and a less close one to dehydrated elpidite (Na 2 ZrSi 6 O 15 ). In both structures, Cs/K atoms occupy large voids. The silicates were obtained through high-temperature flux syntheses. Their crystal structures have been determined from single-crystal X-ray diffraction data. Cs 1.86 K 1.14 DySi 6 O 15 crystallises in R32 (no. 155) with a = 13.896(2), c = 35.623(7) Aa and V = 5957.2(17) Aa 3 , whereas Cs 1.6 K 1.4 SmSi 6 O 15 crystallises in Cmca (no. 64) with a = 14.474(3), b = 14.718(3), c = 15.231(3) Aa and V = 3244.7(11) Aa 3 . The Dy 3+ and Sm 3+ cations present in the silicates cause PL emission bands in the visible yellow-to-orange spectral range. (Copyright copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

A K Mittal

Indian Academy of Sciences (India)

A K Mittal. Articles written in Resonance – Journal of Science Education. Volume 7 Issue 2 February 2002 pp 6-19 General Article. Fractals and the Large-Scale Structure in the Universe - Introduction and Basic Concepts · A K Mittal T R Seshadri · More Details Fulltext PDF. Volume 7 Issue 4 April 2002 pp 39-47 General ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S K Singh. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 561-563. Synthesis of SiC from rice husk in a plasma reactor · S K Singh B C Mohanty S Basu · More Details Abstract Fulltext PDF. A new route for production of SiC from rice husk ...

Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats (

Directory of Open Access Journals (Sweden)

Wu Manlin

2013-08-01

Full Text Available p70 ribosomal S6 kinase (p70S6K can integrate nutrient and growth factor signals to promote cell growth and survival. We report our molecular characterization of the complementary DNA (cDNA that encodes the goat p70S6K gene 40S ribosomal S6 kinase 1 (S6K1 (GenBank accession GU144017 and its 3′ noncoding sequence in Inner Mongolia Cashmere goats (Capra hircus. Goat S6K1 cDNA was 2,272 bp and include an open reading frame (ORF of 1,578 bp, corresponding to a polypeptide of 525 amino acids, and a 694-residue 3′ noncoding sequence with a polyadenylation signal at nucleotides 2,218 to 2,223. The relative abundance of S6K1 mRNA was measured by real-time PCR in 6 tissues, and p70S6K expression was examined by immunohistochemistry in heart and testis. The phosphorylation of p70S6K is regulated by mitogen-activated protein kinase (MAPK signaling in fetal fibroblasts.

New unified fracture toughness estimation scheme for structural integrity assessment

Energy Technology Data Exchange (ETDEWEB)

Wallin, K; Nevasmaa, P [VTT, Espoo (Finland); Bannister, A [Research and Development, British Steel plc., Swinden Technology Centre Rotherham (United Kingdom)

1999-12-31

At present, treatment of fracture toughness data varies depending on the type of data (K{sub IC}, J, CTOD) that are available for fracture mechanics analysis. This complicates structural integrity assessment and makes it difficult to apply any single, unified procedure. Within the Brite-Euram project `SINTAP` a fracture toughness estimation scheme has been developed for the unified treatment of data for use in structural integrity assessment. As a procedure, it can be applied to Charpy data, as well as to fracture toughness data, and is suitable for the treatment of data at both single and different temperatures. The data sets may contain results from both homogeneous and inhomogeneous material, making the procedure applicable also to welded joints. The procedure allows fracture toughness assessment with quantified probability and confidence levels. Irrespective of the type of the original data, one material-specific K{sub mat} value representing a conservative estimate of the mean fracture toughness is obtained (with its probability distribution). This information can then be applied to structural integrity assessment. (orig.) 4 refs.

New unified fracture toughness estimation scheme for structural integrity assessment

Energy Technology Data Exchange (ETDEWEB)

Wallin, K.; Nevasmaa, P. [VTT, Espoo (Finland); Bannister, A. [Research and Development, British Steel plc., Swinden Technology Centre Rotherham (United Kingdom)

1998-12-31

At present, treatment of fracture toughness data varies depending on the type of data (K{sub IC}, J, CTOD) that are available for fracture mechanics analysis. This complicates structural integrity assessment and makes it difficult to apply any single, unified procedure. Within the Brite-Euram project `SINTAP` a fracture toughness estimation scheme has been developed for the unified treatment of data for use in structural integrity assessment. As a procedure, it can be applied to Charpy data, as well as to fracture toughness data, and is suitable for the treatment of data at both single and different temperatures. The data sets may contain results from both homogeneous and inhomogeneous material, making the procedure applicable also to welded joints. The procedure allows fracture toughness assessment with quantified probability and confidence levels. Irrespective of the type of the original data, one material-specific K{sub mat} value representing a conservative estimate of the mean fracture toughness is obtained (with its probability distribution). This information can then be applied to structural integrity assessment. (orig.) 4 refs.

Hydrogen peroxide mediates Rac1 activation of S6K1

International Nuclear Information System (INIS)

Bae, Gyu-Un; Kim, Yong Kee; Kwon, Hyoung-Keun; Park, Jong Woo; Lee, Eun Kyung; Paek, Se Jin; Choi, Wahn Soo; Jung, In Duk; Lee, Hoi Young; Cho, Eun-Jung; Lee, Hyang Woo; Han, Jeung-Whan

2004-01-01

We previously reported that hydrogen peroxide (H 2 O 2 ) mediates mitogen activation of ribosomal protein S6 kinase 1 (S6K1) which plays an important role in cell proliferation and growth. In this study, we investigated a possible role of H 2 O 2 as a molecular linker in Rac1 activation of S6K1. Overexpression of recombinant catalase in NIH-3T3 cells led to the drastic inhibition of H 2 O 2 production by PDGF, which was accompanied by a decrease in S6K1 activity. Similarly, PDGF activation of S6K1 was significantly inhibited by transient transfection or stable transfection of the cells with a dominant-negative Rac1 (Rac1N17), while overexpression of constitutively active Rac1 (Rac1V12) in the cells led to an increase in basal activity of S6K1. In addition, stable transfection of Rat2 cells with Rac1N17 dramatically attenuated the H 2 O 2 production by PDGF as compared with that in the control cells. In contrast, Rat2 cells stably transfected with Rac1V12 produced high level of H 2 O 2 in the absence of PDGF, comparable to that in the control cells stimulated with PDGF. More importantly, elimination of H 2 O 2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H 2 O 2 as a mediator in the activation of S6K1 by Rac1. However, H 2 O 2 could be also produced via other pathway, which is independent of Rac1 or PI3K, because in Rat2 cells stably transfected with Rac1N17, H 2 O 2 could be produced by arsenite, which has been shown to be a stimulator of H 2 O 2 production. Taken together, these results suggest that H 2 O 2 plays a pivotal role as a mediator in Rac1 activation of S6K1

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Chemical Sciences; Volume 113; Issue 5-6. Infrared and Raman spectroscopic studies of glasses with NASICON-type chemistry. K J Rao K C Sobha Sundeep Kumar. Volume 113 Issue 5-6 October-December 2001 pp 497- ...

Grade 6 Science Curriculum Specifications.

Science.gov (United States)

Alberta Dept. of Education, Edmonton. Curriculum Branch.

This material describes curriculum specifications for grade 6 science in Alberta. Emphases recommended are: (1) process skills (50%); (2) psychomotor skills (10%); (3) attitudes (10%); and (4) subject matter (30%). Priorities within each category are identified. (YP)

Natural phenomena evaluations of the K-25 site UF6 cylinder storage yards

International Nuclear Information System (INIS)

Fricke, K.E.

1996-01-01

The K-25 Site UF 6 cylinder storage yards are used for the temporary storage of UF 6 normal assay cylinders and long-term storage of other UF 6 cylinders. The K-25 Site UF 6 cylinder storage yards consist of six on-site areas: K-1066-B, K-1066-E, K-1066-F, K-1066-J, K-1066-K and K-1066-L. There are no permanent structures erected on the cylinder yards, except for five portable buildings. The operating contractor for the K-25 Site is preparing a Safety Analysis Report (SAR) to examine the safety related aspects of the K-25 Site UF 6 cylinder storage yards. The SAR preparation encompasses many tasks terminating in consequence analysis for the release of gaseous and liquid UF 6 , one of which is the evaluation of natural phenomena threats, such as earthquakes, floods, and winds. In support of the SAR, the six active cylinder storage yards were evaluated for vulnerabilities to natural phenomena, earthquakes, high winds and tornados, tornado-generated missiles, floods (local and regional), and lightning. This report summarizes those studies. 30 refs

The Development of a Conceptual Framework for New K-12 Science Education Standards (Invited)

Science.gov (United States)

Keller, T.

2010-12-01

The National Academy of Sciences has created a committee of 18 National Academy of Science and Engineering members, academic scientists, cognitive and learning scientists, and educators, educational policymakers and researchers to develop a framework to guide new K-12 science education standards. The committee began its work in January, 2010, released a draft of the framework in July, 2010, and intends to have the final framework in the first quarter of 2011. The committee was helped in early phases of the work by consultant design teams. The framework is designed to help realize a vision for science and engineering education in which all students actively engage in science and engineering practices in order to deepen their understanding of core ideas in science over multiple years of school. These three dimensions - core disciplinary ideas, science and engineering practices, and cross-cutting elements - must blend together to build an exciting, relevant, and forward looking science education. The framework will be used as a base for development of next generation K-12 science education standards.

Modeling Enterprise Authorization: A Unified Metamodel and Initial Validation

Directory of Open Access Journals (Sweden)

Matus Korman

2016-07-01

Full Text Available Authorization and its enforcement, access control, have stood at the beginning of the art and science of information security, and remain being crucial pillar of security in the information technology (IT and enterprises operations. Dozens of different models of access control have been proposed. Although Enterprise Architecture as the discipline strives to support the management of IT, support for modeling access policies in enterprises is often lacking, both in terms of supporting the variety of individual models of access control nowadays used, and in terms of providing a unified ontology capable of flexibly expressing access policies for all or the most of the models. This study summarizes a number of existing models of access control, proposes a unified metamodel mapped to ArchiMate, and illustrates its use on a selection of example scenarios and two business cases.

IPv6:n käyttöönotto PK-yrityksessä

OpenAIRE

Salonen, Arttu Petteri

2011-01-01

Tämän opinnäytetyön tarkoituksena on selvittää, kuinka IPv6-yhteydet otetaan käyt-töön PK-yrityksessä. Työssä selvitetään minkälaiset vaatimukset IPv6 asettaa lait-teistolle ja minkälaisia käytännön asioita yrityksen täytyy huomioida IPv6:n käyt-töönotossa. Lisäksi työssä on laboratoriosimulaation avulla havainnollistettu eri käyt-töjärjestelmien tukea IPv6:lle ja käyttöönottoon liittyviä reititin- ja osoitekonfiguraati-oita. Käyttöönoton lisäksi opinnäytetyössä esitellään IPv6-protokoll...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 24; Issue 6. Tailoring magnetic and dielectric properties of rubber ferrite composites containing mixed ferrites. M R Anantharaman K A Malini S Sindhu E M Mohammed S K Date S D Kulkarni P A Joy Philip Kurian. Magnetic Materials Volume 24 Issue 6 December 2001 ...

Using the K6 to Assess the Mental Health of Jailed Women

Science.gov (United States)

Kubiak, Sheryl Pimlott; Beeble, Marisa L.; Bybee, Deborah

2009-01-01

Despite high prevalence rates, many jails lack validated measures or consistent processes for detecting mental illness. In this study, we examined the utility of the K6, an internationally used brief mental health screening measure within an urban jail. The K6 and several other mental health measures were administered to 515 jailed women. The K6…

The Р60-S6K1 isoform of ribosomal protein S6 kinase 1 is a product of alternative mRNA translation

Directory of Open Access Journals (Sweden)

I. V. Zaiets

2018-07-01

Full Text Available Ribosomal protein S6 kinase 1 (S6K1 is a well-known downstream effector of mTORC1 (mechanistic target of rapamycin complex 1 participating primarily in the regulation of cell growth and metabolism. Deregulation of mTOR/S6K1 signaling can promote numerous human pathologies, including cancer, neurodegeneration, cardiovascular disease, and metabolic disorders. As existing data suggest, the S6K1 gene encodes several protein isoforms, including p85-S6K1, p70-S6K1, and p60-S6K1. The two of these isoforms, p85-S6K1 and p70-S6K1, were extensively studied to date. The origin and functional significance of the p60-S6K1 isoform remains a mystery, however, it was suggested that the isoform could be a product of alternative S6K1 mRNA translation. Herein we report the generation of HEK-293 cells exclusively expressing p60-S6K1 as a result of CRISPR/Cas9-mediated inactivation of p85/p70-S6K1 translation. Moreover, the generated modified cells displayed the elevated level of p60-S6K1 expression compared to that in wild-type HEK-293 cells. Our data confirm an assumption that p60-S6K1 is alternatively translated, most probably, from the common for both p70- and p85-S6K1 mRNA transcript and reveal a link between p60-S6K1 expression and such cellular processes as cell proliferation and motility. In addition, our findings indicate that the p60-S6K1 isoform of S6K1 may undergo a mode of regulation distinct from p70- and p85-S6K1 due to the absence of mTOR-regulated p60-S6K1 phosphorylation at T389 that is important for S6K1 activation.

KEY COMPARISON: Final report on APMP.M.P-K6.1 pneumatic key comparison from 20 kPa to 105 kPa in gauge mode

Science.gov (United States)

Hung, Chen-Chuan; Jian, Wu; Changpan, Tawat

2009-01-01

This report describes the key comparison APMP.M.P-K6.1 among the three national metrology institutes, Center for Measurement Standards-ITRI (CMS-ITRI, Taiwan), SPRING Singapore and National Institute of Metrology (NIMT), in the pressure range from 20 kPa to 105 kPa in gas media and gauge mode executed during the period April 2003 to April 2004. This comparison was conducted by CMS-ITRI and was based on the calibration procedure of APMP pneumatic pressure comparison APMP.M.P-K6. We intended to link to the CCM.P-K6 key comparison through the APMP.M.P-K6 key comparison by using the proposed linkage method in the APMP.M.P-K6 key comparison to determine a linking factor that can transform the quantities measured in the APMP.M.P-K6.1 key comparison. All three participating institutes used pneumatic piston gauges as their pressure standards. The Ruska 2465 gas-operated piston-cylinder assembly TL-1409 used as transfer standard offered by CMS-ITRI was calibrated three times by the pilot institute during the comparison period and showed that it was very stable after evaluation. The comparison was conducted on the basis of cross-float experiments to determine the effective area of transfer standards from the national standards of three institutes. The comparison results (as shown in Table 6) were equivalent to the CCM.P-K6 comparison and the relative bilateral degrees of equivalence between two laboratories were smaller than 39.7 × 10-6 from 20 kPa to 105 kPa. These results showed all participating institutes measuring the same quantity in the whole pressure range lay within their expanded uncertainty with confidence level 95%. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

Integrating independent research into science curricula to foster STEM leadership

Science.gov (United States)

Queenan, Craig; Calabro, Alyssa; Becker, David

2013-05-01

Preparing students for college and future careers is one of the main goals of K-12 education, but current STEM teaching methods do not do enough to interest students and leave them prepared to enter into and succeed in STEM careers. While measures to implement unifying standards for science education across the country are aimed at ensuring that all students are taught the same material at each grade level, a shift in the way science is taught to is needed to complete the redesign of science education. The independent research model described here aligns with the new content standards and focuses on developing the principles of perspective, purpose, resources, collaboration, analysis, and presentation. These principles not only engage students in the classroom, but also leave students prepared to enter into science programs in college and succeed in leadership roles in the STEM workforce.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science; Volume 120; Issue 6. Anthropogenic and impact spherules: Morphological similarity and chemical distinction – A case study from India and its implications. Ambalika Niyogi Jayanta K Pati Suresh C Patel Dipak Panda Shiv K Patil. Volume 120 Issue 6 December 2011 pp ...

A unified theory of development: a dialectic integration of nature and nurture.

Science.gov (United States)

Sameroff, Arnold

2010-01-01

The understanding of nature and nurture within developmental science has evolved with alternating ascendance of one or the other as primary explanations for individual differences in life course trajectories of success or failure. A dialectical perspective emphasizing the interconnectedness of individual and context is suggested to interpret the evolution of developmental science in similar terms to those necessary to explain the development of individual children. A unified theory of development is proposed to integrate personal change, context, regulation, and representational models of development.

An analysis of program planning in schools with emerging excellence in science instructional design

Science.gov (United States)

Carroll, Karen Marie

Science educators agree on many of the program elements that characterize exemplary science instructional programs, but it has not been clear how the processes of planning and implementation lead to excellence in program design. This study focuses on two K--12 school clusters located in unified school districts and one K--12 school cluster spanning two non-unified districts that are in the midst of building new science programs. The clusters were selected for support by an organization of educators, scientists, and businesspersons because they were recognized as likely to produce good programs. The investigation centers on three research questions: (1) To what extent have schools engaged in science education reform achieved excellence? (2) How did schools engaged in science program improvement go about achieving their goals, and (3) What contextual factors are most closely related to the realization of quality program elements? The degree to which each program studied met indicators of quality suggested by the National Science Education Standards (NSES) are described according to an Innovation Configuration (IC) Chart. Using a Stream Diagnostic method of analysis, levels of practice were associated with contextual factors categorized as Social, Organizing, and Resource. Findings reveal the importance of a balanced and synchronized function of all components, including administrative commitment, teacher participation, and favorable logistical aspects. Individual reform projects were more likely to be successful if they included exemplary program elements and mechanisms for program managers to access district personnel and procedures needed to implement programs. A review of the cluster case histories also revealed the positive impact of cooperation between the funding organization and the project, the degree to which professional development is directly related to the new program, and the availability of resources and support for each exemplary program element.

Generalized Information Theory Meets Human Cognition: Introducing a Unified Framework to Model Uncertainty and Information Search.

Science.gov (United States)

Crupi, Vincenzo; Nelson, Jonathan D; Meder, Björn; Cevolani, Gustavo; Tentori, Katya

2018-06-17

Searching for information is critical in many situations. In medicine, for instance, careful choice of a diagnostic test can help narrow down the range of plausible diseases that the patient might have. In a probabilistic framework, test selection is often modeled by assuming that people's goal is to reduce uncertainty about possible states of the world. In cognitive science, psychology, and medical decision making, Shannon entropy is the most prominent and most widely used model to formalize probabilistic uncertainty and the reduction thereof. However, a variety of alternative entropy metrics (Hartley, Quadratic, Tsallis, Rényi, and more) are popular in the social and the natural sciences, computer science, and philosophy of science. Particular entropy measures have been predominant in particular research areas, and it is often an open issue whether these divergences emerge from different theoretical and practical goals or are merely due to historical accident. Cutting across disciplinary boundaries, we show that several entropy and entropy reduction measures arise as special cases in a unified formalism, the Sharma-Mittal framework. Using mathematical results, computer simulations, and analyses of published behavioral data, we discuss four key questions: How do various entropy models relate to each other? What insights can be obtained by considering diverse entropy models within a unified framework? What is the psychological plausibility of different entropy models? What new questions and insights for research on human information acquisition follow? Our work provides several new pathways for theoretical and empirical research, reconciling apparently conflicting approaches and empirical findings within a comprehensive and unified information-theoretic formalism. Copyright © 2018 Cognitive Science Society, Inc.

The performance of the K10, K6 and GHQ-12 to screen for present state DSM-IV disorders among disability claimants

Directory of Open Access Journals (Sweden)

Cornelius Bert LR

2013-02-01

Full Text Available Abstract Background Screening for mental disorders among disability claimants is important, since mental disorders seem to be seriously under-recognized in this population. However, performance of potentially suitable scales is unknown. We aimed to evaluate the psychometric properties of three scales, the 10- and 6-item Kessler Psychological Distress Scale (K10, K6 and the 12-item General Health Questionnaire (GHQ-12, to predict present state mental disorders, classified according to the Diagnostic and Statistical Manual of Mental Disorders, 4thEdition (DSM-IV among disability claimants. Methods All scales were completed by a representative sample of persons claiming disability benefit after two years sickness absence (n=293. All diagnoses, both somatic and mental, were included. The gold standard was the Composite International Diagnostic Interview (CIDI 3.0 to diagnose present state DSM-IV disorder. Cronbach’s α, sensitivity, specificity, positive (PPV and negative predictive values (NPV, and the areas under the Receiver Operating Characteristic curve (AUC were calculated. Results Cronbach’s alpha’s were 0.919 (K10, 0.882 (K6 and 0.906 (GHQ-12. The optimal cut-off scores were 24 (K10, 14 ( K6 and 20 (GHQ-12. The PPV and the NPV for the optimal cut point of the K10 was 0.53 and 0.89, for the K6 0.51 and 0.87, and for the GHQ-12 0.50 and 0.82. The AUC’s for 30-day cases were 0.806 (K10; 95% CI 0.749-0.862, 0.796 (K6; 95% CI 0.737-0.854 and 0.695 (GHQ-12; 95% CI 0.626-0.765. Conclusions The K10 and K6 are reliable and valid scales to screen for present state DSM-IV mental disorder. The optimal cut-off scores are 24 (K10 and 14 (K6. The GHQ-12 (optimal cut-off score: 20 is outperformed by the K10 and K6, which are to be preferred above the GHQ-12. The scores on separate items of the K10 and K6 can be used in disability assessment settings as an agenda for an in-depth follow-up clinical interview to ascertain the presence of present state

The three constituencies of the state: why the state has lost unifying energy.

Science.gov (United States)

King, Desmond; Le Galès, Patrick

2017-11-01

We address resurgent populism by examining structural processes of state transformation in the UK, the US and France. Scholars stress the 'unifying energy of the state', a set of institutions and policies capable of limiting inequalities and defending legal regimes. One characteristic of modern Western statehood were packages of policies designed to integrate social groups and territories in part by ensuring common standards of provision and social citizenship across the nation state. This echoes James Scott's critical analysis of the modernist project of the state (1998). This 'unifying energy' had different origins including nationalist movements, combatting external influence or powers, war, and preparing citizens for the rigours of industrialization. Overcoming class differences and territorial differences (including cultural, social and economic differences) was a major source of mobilization to feed this 'unifying energy of the state' in France, Italy or Spain for instance. Political and cultural identities are related in significant part to respective nation states. We argue that this 'unifying energy' was an essential component of statehood in Europe and in the US. It is now largely lost. We explain why and the significance of its displacement. © London School of Economics and Political Science 2017.

Unified Symmetry of Hamilton Systems

International Nuclear Information System (INIS)

Xu Xuejun; Qin Maochang; Mei Fengxiang

2005-01-01

The definition and the criterion of a unified symmetry for a Hamilton system are presented. The sufficient condition under which the Noether symmetry is a unified symmetry for the system is given. A new conserved quantity, as well as the Noether conserved quantity and the Hojman conserved quantity, deduced from the unified symmetry, is obtained. An example is finally given to illustrate the application of the results.

Inequality in societies, academic institutions and science journals: Gini and k-indices

Science.gov (United States)

Ghosh, Asim; Chattopadhyay, Nachiketa; Chakrabarti, Bikas K.

2014-09-01

Social inequality is traditionally measured by the Gini-index (g). The g-index takes values from 0 to 1 where g=0 represents complete equality and g=1 represents complete inequality. Most of the estimates of the income or wealth data indicate the g value to be widely dispersed across the countries of the world: g values typically range from 0.30 to 0.65 at a particular time (year). We estimated similarly the Gini-index for the citations earned by the yearly publications of various academic institutions and the science journals. The ISI web of science data suggests remarkably strong inequality and universality (g=0.70±0.07) across all the universities and institutions of the world, while for the journals we find g=0.65±0.15 for any typical year. We define a new inequality measure, namely the k-index, saying that the cumulative income or citations of (1-k) fraction of people or papers exceed those earned by the fraction (k) of the people or publications respectively. We find, while the k-index value for income ranges from 0.60 to 0.75 for income distributions across the world, it has a value around 0.75±0.05 for different universities and institutions across the world and around 0.77±0.10 for the science journals. Apart from above indices, we also analyze the same institution and journal citation data by measuring Pietra index and median index.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Bajpai. Articles written in Bulletin of Materials Science. Volume 28 Issue 6 October 2005 pp 529-534 Review—Polymers. Morphological, thermal and annealed microhardness characterization of gelatin based interpenetrating networks of polyacrylonitrile: A hard biopolymer.

Bacterial Electrocatalysis of K4[Fe(CN)6] Oxidation

DEFF Research Database (Denmark)

Zheng, Zhiyong; Xiao, Yong; Wu, Ranran

Shewanella oneidensis MR-1 (MR-1), a model strain of electrochemically active bacteria, can transfer electrons from cell to extracellular electron acceptors including Fe(III) (hydro)oxides. It has been reported that several redox species such as cytochromes in membranes and flavins assist...... in the electron transport (ET) processes. However, the oxidization of metal compounds was barely described. Here we report electrocatalysis of K4[Fe(CN)6] oxidation by MR-1. K4[Fe(CN)6] is a redox inorganic compound and shows a reversible redox process on bare glassy carbon (GCE). This is reflected by a pair...

Problem-Based Learning in the Physical Science Classroom, K-12

Science.gov (United States)

McConnell, Tom J.; Parker, Joyce; Eberhardt, Janet

2018-01-01

"Problem-Based Learning in the Physical Science Classroom, K-12" will help your students truly understand concepts such as motion, energy, and magnetism in true-to-life contexts. The book offers a comprehensive description of why, how, and when to implement problem-based learning (PBL) in your curriculum. Its 14 developmentally…

Determination of the enthalpy of fusion of K{sub 3}TaF{sub 8} and K{sub 3}TaOF{sub 6}

Energy Technology Data Exchange (ETDEWEB)

Kosa, L. [Institute of Inorganic Chemistry, Slovak Academy of Sciences, SK-845 36 Bratislava (Slovakia)]. E-mail: uachkosa@savba.sk; Mackova, I. [Institute of Inorganic Chemistry, Slovak Academy of Sciences, SK-845 36 Bratislava (Slovakia)

2006-08-15

The areas of the fusion and crystallization peaks of K{sub 3}TaF{sub 8} and K{sub 3}TaOF{sub 6} have been measured using the DSC mode of the high-temperature calorimeter (SETARAM 1800 K). On the basis of these quantities and the temperature dependence of the used calorimetric method sensitivity, the values of the enthalpy of fusion of K{sub 3}TaF{sub 8} at temperature of fusion 1039 K: {delta}{sub fus} H {sub m}(K{sub 3}TaF{sub 8}; 1039 K) = (52 {+-} 2) kJ mol{sup -1} and of K{sub 3}TaOF{sub 6} at temperature of fusion 1055 K: {delta}{sub fus} H {sub m}(K{sub 3}TaOF{sub 6}; 1055 K) = (62 {+-} 3) kJ mol{sup -1} have been determined.

Cataclysms and Catastrophes: A Case Study of Improving K-12 Science Education Through a University Partnership

Science.gov (United States)

Fennell, T.; Ellins, K. K.; Morris, M.; Christeson, G.

2003-12-01

The K-12 science teacher is always seeking ways of improving and updating their curriculum by integrating the latest research into their most effective classroom activities. However, the daily demands of delivering instruction to large numbers of students coupled with the rapid advances in some fields of science can often overwhelm this effort. The NSF-sponsored Cataclysms and Catastrophes curriculum, developed by scientists from the The University of Texas at Austin Institute for Geophysics (UTIG) and Bureau of Economic Geology (BEG), middle and high school teachers, and UT graduate students (NSF GK-12 fellows) working together through the GK-12 program, is a textbook example of how universities can facilitate this quest, benefiting education at both K-12 and university levels. In 1992, "The Great K-T Extinction Debate" was developed as an activity in the Planet Earth class at the Liberal Arts and Science Academy of Austin as an interdisciplinary approach to science. Taking advantage of the media attention generated by the impact scenario for the K-T extinction, the activity consists of students participating in a simulated senate hearing on the potential causes of the K-T extinction and their implications for society today. This activity not only exposes students to the wide range of science involved in understanding mass extinctions, but also to the social, political and economic implications when this science is brought into the public arena and the corresponding use of data in decision making and disaster preparedness. While "The Great K-T Extinction Debate" was always a popular and effective activity with students, it was in desperate need of updating to keep pace with the evolving scientific debate over the cause of the K-T extinction and the growing body of impact evidence discovered over the past decade. By adding two inquiry-based learning activities that use real geophysical data collected by scientists studying the buried Chicxulub feature as a

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. ATANU BARIK. Articles written in Journal of Chemical Sciences. Volume 117 Issue 6 November 2005 pp 641-647. Fluorescence spectroscopic studies on binding of a flavonoid antioxidant quercetin to serum albumins · Beena Mishra Atanu Barik K Indira Priyadarsini Hari ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Atanu Barik. Articles written in Journal of Chemical Sciences. Volume 117 Issue 6 November 2005 pp 641-647. Fluorescence spectroscopic studies on binding of a flavonoid antioxidant quercetin to serum albumins · Beena Mishra Atanu Barik K Indira Priyadarsini Hari Mohan.

Viscosity of melts of the system KCl-KBF4-K2TiF6

International Nuclear Information System (INIS)

Nguyen, D.K.; Danek, V.

1997-01-01

The viscosity of melts of the system KCl-KBF 4 -K 2 TiF 6 has been measured by means of the computerized torsional pendulum method. The viscosity of KCl is higher that of KBF 4 at the same temperature, most probably due to the substantial overheating of KBF 4 . In the ternary system the viscosity increases with increasing with increasing content of K 2 TiF 6 . Additivity of algorithms of viscosity was adopted as the ideal behaviour of the mixture. Negative deviations from such additive behaviour were found in the binary system KCl-KBF 4 probably due to the breaks of the weak B-Cl-B bridges caused by the excess of Cl - ions. Positive deviations from the ideal behaviour were found in the binaries KCl-K 2 TiF 6 and KBF 4 -K 2 TiF 6 due to the formation of larger anions TiF 6 Cl 3- and TiF 7 3- caused by the reactions K 2 TiF 6 (l) + KCl(l) = K 3 TiF 6 Cl(l) and KBF 4 (l) + K 2 TiF 6 (l) = K 3 TiF 7 (l) + BF 3 (g). Statistically significant ternary interaction confirmed that the above chemical reactions take place also in the ternary system. (authors)

Alteration of Na-K pump activity in supersensitive rat caudal artery following 6-hydroxydopamine (6-OHDA) treatment

International Nuclear Information System (INIS)

Wong, S.K.; Foley, D.H.

1986-01-01

Contractile response and the Na-K pump activity, measured as ouabain-sensitive 86 Rb-uptake, were determined in caudal artery strips of rats pretreated with 6-OHDA. At 6-7 days after 6-OHDA treatment, the potencies of norepinephrine and serotonin in causing contraction of rat caudal artery were significantly increased by 2.3 - and 1.7 - fold respectively. There was, however, no change in maximum contractile response to either agent. Treatment with 6-OHDA also reduced endogenous catecholamine content of the caudal artery to 7% of the control. Analysis of ouabain-inhibitable 86 Rb-uptake of rat caudal artery by the double-reciprocal plots showed that both the rate of 86 Rb-uptake and the affinity for rubidium were depressed after 6-OHDA treatment. The results indicate that 6-OHDA induced supersensitivity in the rat caudal artery is associated with a decrease in the Na-K pump activity. These data provide additional support to the concept that inhibition of the Na-K pump may result in partial depolarization of the cell membrane which leads to supersensitivity of smooth muscle to excitatory drugs

Germline mutations in MAP3K6 are associated with familial gastric cancer.

Directory of Open Access Journals (Sweden)

Daniel Gaston

2014-10-01

Full Text Available Gastric cancer is among the leading causes of cancer-related deaths worldwide. While heritable forms of gastric cancer are relatively rare, identifying the genes responsible for such cases can inform diagnosis and treatment for both hereditary and sporadic cases of gastric cancer. Mutations in the E-cadherin gene, CDH1, account for 40% of the most common form of familial gastric cancer (FGC, hereditary diffuse gastric cancer (HDGC. The genes responsible for the remaining forms of FGC are currently unknown. Here we examined a large family from Maritime Canada with FGC without CDH1 mutations, and identified a germline coding variant (p.P946L in mitogen-activated protein kinase kinase kinase 6 (MAP3K6. Based on conservation, predicted pathogenicity and a known role of the gene in cancer predisposition, MAP3K6 was considered a strong candidate and was investigated further. Screening of an additional 115 unrelated individuals with non-CDH1 FGC identified the p.P946L MAP3K6 variant, as well as four additional coding variants in MAP3K6 (p.F849Sfs*142, p.P958T, p.D200Y and p.V207G. A somatic second-hit variant (p.H506Y was present in DNA obtained from one of the tumor specimens, and evidence of DNA hypermethylation within the MAP3K6 gene was observed in DNA from the tumor of another affected individual. These findings, together with previous evidence from mouse models that MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for FGC.

Unified Bessel, Modified Bessel, Spherical Bessel and Bessel-Clifford Functions

OpenAIRE

Yaşar, Banu Yılmaz; Özarslan, Mehmet Ali

2016-01-01

In the present paper, unification of Bessel, modified Bessel, spherical Bessel and Bessel-Clifford functions via the generalized Pochhammer symbol [ Srivastava HM, Cetinkaya A, K{\\i}ymaz O. A certain generalized Pochhammer symbol and its applications to hypergeometric functions. Applied Mathematics and Computation, 2014, 226 : 484-491] is defined. Several potentially useful properties of the unified family such as generating function, integral representation, Laplace transform and Mellin tran...

Conceptual definition of a 50-100 kWe NEP system for planetary science missions

Science.gov (United States)

Friedlander, Alan

1993-01-01

The Phase 1 objective of this project is to assess the applicability of a common Nuclear Electric Propulsion (NEP) flight system of the 50-100 kWe power class to meet the advanced transportation requirements of a suite of planetary science (robotic) missions, accounting for differences in mission-specific payloads and delivery requirements. The candidate missions are as follows: (1) Comet Nucleus Sample Return; (2) Multiple Mainbelt Asteroid Rendezvous; (3) Jupiter Grand Tour (Galilean satellites and magnetosphere); (4) Uranus Orbiter/Probe (atmospheric entry and landers); (5) Neptune Orbiter/Probe (atmospheric entry and landers); and (6) Pluto-Charon Orbiter/Lander. The discussion is presented in vugraph form.

Assessing the life science knowledge of students and teachers represented by the K-8 national science standards.

Science.gov (United States)

Sadler, Philip M; Coyle, Harold; Smith, Nancy Cook; Miller, Jaimie; Mintzes, Joel; Tanner, Kimberly; Murray, John

2013-01-01

We report on the development of an item test bank and associated instruments based on the National Research Council (NRC) K-8 life sciences content standards. Utilizing hundreds of studies in the science education research literature on student misconceptions, we constructed 476 unique multiple-choice items that measure the degree to which test takers hold either a misconception or an accepted scientific view. Tested nationally with 30,594 students, following their study of life science, and their 353 teachers, these items reveal a range of interesting results, particularly student difficulties in mastering the NRC standards. Teachers also answered test items and demonstrated a high level of subject matter knowledge reflecting the standards of the grade level at which they teach, but exhibiting few misconceptions of their own. In addition, teachers predicted the difficulty of each item for their students and which of the wrong answers would be the most popular. Teachers were found to generally overestimate their own students' performance and to have a high level of awareness of the particular misconceptions that their students hold on the K-4 standards, but a low level of awareness of misconceptions related to the 5-8 standards.

Involving Practicing Scientists in K-12 Science Teacher Professional Development

Science.gov (United States)

Bertram, K. B.

2011-12-01

The Science Teacher Education Program (STEP) offered a unique framework for creating professional development courses focused on Arctic research from 2006-2009. Under the STEP framework, science, technology, engineering, and math (STEM) training was delivered by teams of practicing Arctic researchers in partnership with master teachers with 20+ years experience teaching STEM content in K-12 classrooms. Courses based on the framework were offered to educators across Alaska. STEP offered in-person summer-intensive institutes and follow-on audio-conferenced field-test courses during the academic year, supplemented by online scientist mentorship for teachers. During STEP courses, teams of scientists offered in-depth STEM content instruction at the graduate level for teachers of all grade levels. STEP graduate-level training culminated in the translation of information and data learned from Arctic scientists into standard-aligned lessons designed for immediate use in K-12 classrooms. This presentation will focus on research that explored the question: To what degree was scientist involvement beneficial to teacher training and to what degree was STEP scientist involvement beneficial to scientist instructors? Data sources reveal consistently high levels of ongoing (4 year) scientist and teacher participation; high STEM content learning outcomes for teachers; high STEM content learning outcomes for students; high ratings of STEP courses by scientists and teachers; and a discussion of the reasons scientists indicate they benefited from STEP involvement. Analyses of open-ended comments by teachers and scientists support and clarify these findings. A grounded theory approach was used to analyze teacher and scientist qualitative feedback. Comments were coded and patterns analyzed in three databases. The vast majority of teacher open-ended comments indicate that STEP involvement improved K-12 STEM classroom instruction, and the vast majority of scientist open-ended comments

Why unify

International Nuclear Information System (INIS)

Georgi, H.

1980-01-01

Unified gauge theories such as SU(5) of particle interactions are built on the colour SU(3) and SU(2) x U(1) gauge theories which apparently describe strong and weak and electromagnetic interactions at distances as small as 10 -16 cm. In this article the classical reasons for going beyond SU(3)xSU(2)xU(1) to a fully unified theory such as SU(5) are reviewed, and a new reason formulated. A class of imaginary worlds similar to our own is considered and it is shown that unification is possible only in ours. This suggests that the low-energy interactions are unique in that they are constructed to make unification possible. (author)

Swapan K Ghosh | Speakers | Indian Academy of Sciences

Indian Academy of Sciences (India)

In spite of the differences in the nature of the density variables used in all these DFT-based descriptions, the corresponding theoretical frameworks, which project the many-particle picture to a single-particle one, have been found to possess an underlying unified structure. Some of these developments and applications of ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Farman Ali. Articles written in Journal of Chemical Sciences. Volume 122 Issue 6 November 2010 pp 847-855 Full Papers. Blue and white light electroluminescence in a multilayer OLED using a new aluminium complex · Pabitra K Nayak Neeraj Agarwal Farman Ali Meghan P ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Jadu Samuel. Articles written in Bulletin of Materials Science. Volume 36 Issue 6 November 2013 pp 981-987. Green chemical incorporation of sulphate into polyoxoanions of molybdenum to nano level · Jadu Samuel S Hari Prasad M K Sreedhar · More Details Abstract Fulltext ...

Seven Deadliest Unified Communications Attacks

CERN Document Server

York, Dan

2010-01-01

Do you need to keep up with the latest hacks, attacks, and exploits effecting Unified Communications technology? Then you need Seven Deadliest Unified Communication Attacks. This book pinpoints the most dangerous hacks and exploits specific to Unified Communications, laying out the anatomy of these attacks including how to make your system more secure. You will discover the best ways to defend against these vicious hacks with step-by-step instruction and learn techniques to make your computer and network impenetrable. Attacks featured in this book include: UC Ecosystem Attacks Insecure Endpo

Proceedings of the 6. Japan-Brazil Symposium on Science and Technology

International Nuclear Information System (INIS)

1988-01-01

Researches carried out on: applications of radiation and radioisotopes; ceramics; environment; metals and alloys; nuclear safety; radiation protection; plasma; and space science, are presented. (M.C.K.) [pt

Neutron-diffraction study of cubic ErC/sub 0.6/ in the temperature range 1.6--296 K

International Nuclear Information System (INIS)

Atoji, M.

1981-01-01

Neutron-diffraction measurements have shown that the form of ErC/sub 0.6/ that has a cubic, NaCl-type structure is paramagnetic above 90 K, exhibiting a free Er 3+ moment. Below 90 K, ErC/sub 0.6/ becomes a ferromagnet with a saturation moment of 2.5 Bohr magnetons (only 28% of the maximum free-ion moment), indicating a large crystal-field effect. By measuring the preferential crystallite orientation induced by the applied magnetic field, the direction of the ferromagnetically ordered moment was found to be parallel to the axis. A ferromagnetic, short-range ordering coexists with the ferromagnetic long-range ordering at temperatures down to 1.6 K

In silico binding affinity studies of N-9 substituted 6-(4-(4-propoxyphenylpiperazin-1-yl-9H-purine derivatives-Target for P70-S6K1 & PI3K-δ kinases

Directory of Open Access Journals (Sweden)

Manjunath G. Sunagar

2018-03-01

Full Text Available P70-S6K1 & PI3K-δ kinases are identified to be involved in many physiological processes associated with cancer, therefore many of the inhibitors being designed to target these kinases are in clinical trials. In the current study we have exploited the N-9 substituted 6-(4-(4-propoxyphenyl piperazin-1-yl-9H-purine derivatives for their inhibitory properties with the above kinases. We have used an in silico docking study with seventeen purine derivatives for their binding affinity calculations. The binding affinities of these small molecules with P70-S6K1 & PI3K-δ were performed using AutoDock Vina. Among all the compounds, PP16 showed highest binding affinity of −14.7 kcal/mol with P70-S6K1 kinase & −17.2 kcal/mol with PI3K-δ kinases as compared to the molecules under clinical trials (PF-4708671 & IC-87114. Docking studies revealed that N-9 coumarine substituted purine derivative could be one of the potential ligands for the inhibition of P70-S6K1 & PI3K-δ kinases. Hence, this compound can be further investigated by in vitro and in vivo experiments for further validation.

6K2-induced vesicles can move cell to cell during turnip mosaic virus infection

Directory of Open Access Journals (Sweden)

Romain eGrangeon

2013-12-01

Full Text Available To successfully infect plants, viruses replicate in an initially infected cell and then move to neighboring cells through plasmodesmata (PDs. However, the nature of the viral entity that crosses over the cell barrier into non-infected ones is not clear. The membrane-associated 6K2 protein of turnip mosaic virus (TuMV induces the formation of vesicles involved in the replication and intracellular movement of viral RNA. This study shows that 6K2-induced vesicles trafficked towards the plasma membrane and were associated with plasmodesmata (PD. We demonstrated also that 6K2 moved cell-to-cell into adjoining cells when plants were infected with TuMV. 6K2 was then fused to photo-activable GFP (6K2:PAGFP to visualize how 6K2 move intercellularly during TuMV infection. After activation, 6K2:PAGFP-tagged vesicles moved to the cell periphery and across the cell wall into adjacent cells. These vesicles were shown to contain the viral RNA-dependent RNA polymerase and viral RNA. Symplasmic movement of TuMV may thus be achieved in the form of a membrane-associated viral RNA complex induced by 6K2.

Unifying Abstractions

DEFF Research Database (Denmark)

Torgersen, Mads

This thesis presents the RUNE language, a semantic construction of related and tightly coupled programming constructs presented in the shape of a programming language. The major contribution is the succesfull design of a highly unified and general programming model, capable of expressing some of ...... a unified name declaration mechanism. The resulting expressiveness allows for argument covariance, dependent types and module types, plus a solution to the so-called expression problem of two way extensibility in object-oriented languages....... of the most complex type relations put forth in type systems research, without compromising such fundamental qualities as conceptuality, modularity and static typing. While many new constructs and unifications are put forth  to substantiate their conceptual validity, type rules are given to support...

Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1

International Nuclear Information System (INIS)

Park, In-Hyun; Erbay, Ebru; Nuzzi, Paul; Chen Jie

2005-01-01

The protein kinase mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and growth, with the ribosomal subunit S6 kinase 1 (S6K1) as one of the key downstream signaling effectors. A critical role of mTOR signaling in skeletal muscle differentiation has been identified recently, and an unusual regulatory mechanism independent of mTOR kinase activity and S6K1 is revealed. An mTOR pathway has also been reported to regulate skeletal muscle hypertrophy, but the regulatory mechanism is not completely understood. Here, we report the investigation of mTOR's function in insulin growth factor I (IGF-I)-induced C2C12 myotube hypertrophy. Added at a later stage when rapamycin no longer had any effect on normal myocyte differentiation, rapamycin completely blocked myocyte hypertrophy as measured by myotube diameter. Importantly, a concerted increase of average myonuclei per myotube was observed in IGF-I-stimulated myotubes, which was also inhibited by rapamycin added at a time when it no longer affected normal differentiation. The mTOR protein level, its catalytic activity, its phosphorylation on Ser2448, and the activity of S6K1 were all found increased in IGF-I-stimulated myotubes compared to unstimulated myotubes. Using C2C12 cells stably expressing rapamycin-resistant forms of mTOR and S6K1, we provide genetic evidence for the requirement of mTOR and its downstream effector S6K1 in the regulation of myotube hypertrophy. Our results suggest distinct mTOR signaling mechanisms in different stages of skeletal muscle development: While mTOR regulates the initial myoblast differentiation in a kinase-independent and S6K1-independent manner, the hypertrophic function of mTOR requires its kinase activity and employs S6K1 as a downstream effector

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 125; Issue 6. Reactivity of allenylphosphonates and allenylphosphine oxides toward 9-chloroacridines and acridone- A facile route to new -substituted acridones. A Leela Siva Kumari Venu Srinivas K C Kumara Swamy. Regular Articles Volume 125 Issue 6 ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 116; Issue 6. Studies of effect of heterocyclic dyes in photogalvanic cells for solar energy conversion and storage: NaLS-ascorbic acid system. K R Genwa Anju Chouhan. Volume 116 Issue 6 November 2004 pp 339-345 ...

A unified view of "how allostery works".

Science.gov (United States)

Tsai, Chung-Jung; Nussinov, Ruth

2014-02-01

The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second, its vast practical importance. Allostery is at play in all processes in the living cell, and increasingly in drug discovery. Many models have been successfully formulated, and are able to describe allostery even in the absence of a detailed structural mechanism. However, conceptual schemes designed to qualitatively explain allosteric mechanisms usually lack a quantitative mathematical model, and are unable to link its thermodynamic and structural foundations. This hampers insight into oncogenic mutations in cancer progression and biased agonists' actions. Here, we describe how allostery works from three different standpoints: thermodynamics, free energy landscape of population shift, and structure; all with exactly the same allosteric descriptors. This results in a unified view which not only clarifies the elusive allosteric mechanism but also provides structural grasp of agonist-mediated signaling pathways, and guides allosteric drug discovery. Of note, the unified view reasons that allosteric coupling (or communication) does not determine the allosteric efficacy; however, a communication channel is what makes potential binding sites allosteric.

X-ray photoelectron spectroscopy as detection tool for coordinated or uncoordinated fluorine atoms demonstrated on fluoride systems NaF, K2TaF7, K3TaF8, K2ZrF6, Na7Zr6F31 and K3ZrF7

Science.gov (United States)

Boča, Miroslav; Barborík, Peter; Mičušík, Matej; Omastová, Mária

2012-07-01

While systems K3TaF8 and K3ZrF7 were prepared by modified molten salt method modified wet pathway was used for reproducible preparation of Na7Zr6F31. Its congruently melting character was demonstrated on simultaneous TG/DSC measurements and XRD patterns. X-ray photoelectron spectroscopy was applied for identification of differently bonded fluorine atoms in series of compounds NaF, K2TaF7, K3TaF8, K2ZrF6, Na7Zr6F31 and K3ZrF7. Three different types of fluorine atoms were described qualitatively and quantitatively. Uncoordinated fluorine atoms (F-) provide signals at lowest binding energies, followed by signals from terminally coordinated fluorine atoms (M-F) and then bridging fluorine atoms (M-F-M) at highest energy. Based on XPS F 1s signals assigned to fluorine atoms in compounds with correctly determined structure it was suggested that fluorine atoms in K3ZrF7 have partially bridging character.

Unified description of quasi-free and resonant processes of hypernuclear production and decay

International Nuclear Information System (INIS)

Wuensch, R.

1992-03-01

We review a unified description of resonant and quasi-free hypernuclear production reactions on the basis of the continuum shell-model. Both reaction mechanisms are considered as boundary cases of the same process. We apply the model to the (K - , π) and to the (π, K + ) reaction on light target nuclei. Particular attention is given to the consequences of the shallow hyperon-nucleus potential. Hypernuclear disintegration by baryon emission is considered as transition from the bound to the unbound part of the configurational space. (orig.)

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Amit Sinha. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 653-657 Bioceramics. Development of calcium phosphate based bioceramics · Amit Sinha A Ingle K R Munim S N Vaidya B P Sharma A N Bhisey · More Details Abstract Fulltext ...

Involvement of S6K1 in mitochondria function and structure in HeLa cells.

Science.gov (United States)

Park, Jisoo; Tran, Quangdon; Mun, Kisun; Masuda, Kouhei; Kwon, So Hee; Kim, Seon-Hwan; Kim, Dong-Hoon; Thomas, George; Park, Jongsun

2016-12-01

The major biological function of mitochondria is to generate cellular energy through oxidative phosphorylation. Apart from cellular respiration, mitochondria also play a key role in signaling processes, including aging and cancer metabolism. It has been shown that S6K1-knockout mice are resistant to obesity due to enhanced beta-oxidation, with an increased number of large mitochondria. Therefore, in this report, the possible involvement of S6K1 in regulating mitochondria dynamics and function has been investigated in stable lenti-shS6K1-HeLa cells. Interestingly, S6K1-stably depleted HeLa cells showed phenotypical changes in mitochondria morphology. This observation was further confirmed by detailed image analysis of mitochondria shape. Corresponding molecular changes were also observed in these cells, such as the induction of mitochondrial fission proteins (Drp1 and Fis1). Oxygen consumption is elevated in S6K1-depeleted HeLa cells and FL5.12 cells. In addition, S6K1 depletion leads to enhancement of ATP production in cytoplasm and mitochondria. However, the relative ratio of mitochondrial ATP to cytoplasmic ATP is actually decreased in lenti-shS6K1-HeLa cells compared to control cells. Lastly, induction of mitophagy was found in lenti-shS6K1-HeLa cells with corresponding changes of mitochondria shape on electron microscope analysis. Taken together, our results indicate that S6K1 is involved in the regulation of mitochondria morphology and function in HeLa cells. This study will provide novel insights into S6K1 function in mitochondria-mediated cellular signaling. Copyright © 2016 Elsevier Inc. All rights reserved.

Power cables with extruded insulation and their accessories for rated voltages from 1 kV (Um = 1,2 kV) up to 30 kV (Um = 36 kV) : Part 2: cables for rated voltages from 6 kV (Um = 7,2 kV) up to 30 kV (Um = 36 kV)

CERN Document Server

International Electrotechnical Commission. Geneva

2005-01-01

Power cables with extruded insulation and their accessories for rated voltages from 1 kV (Um = 1,2 kV) up to 30 kV (Um = 36 kV) : Part 2: cables for rated voltages from 6 kV (Um = 7,2 kV) up to 30 kV (Um = 36 kV)

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Chemical Sciences; Volume 128; Issue 6. Amidinate Ligands in Zinc coordination sphere: Synthesis and structural diversity. SRINIVAS ANGA INDRANI BANERJEE TARUN K PANDA. Regular Article Volume 128 Issue 6 June 2016 pp 867-873 ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 117; Issue 3. Supramolecular assembly based on a heteropolyanion: Synthesis and crystal structure of Na3(H2O)6[Al(OH)6Mo6O18] ⋅ 2H2O. Vaddypally Shivaiah Samar K Das. Volume 117 Issue 3 May 2005 pp 227-233 ...

S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy.

Science.gov (United States)

Marabita, Manuela; Baraldo, Martina; Solagna, Francesca; Ceelen, Judith Johanna Maria; Sartori, Roberta; Nolte, Hendrik; Nemazanyy, Ivan; Pyronnet, Stéphane; Kruger, Marcus; Pende, Mario; Blaauw, Bert

2016-10-04

Loss of skeletal muscle mass and force aggravates age-related sarcopenia and numerous pathologies, such as cancer and diabetes. The AKT-mTORC1 pathway plays a major role in stimulating adult muscle growth; however, the functional role of its downstream mediators in vivo is unknown. Here, we show that simultaneous inhibition of mTOR signaling to both S6K1 and 4E-BP1 is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin. Surprisingly, lack of mTOR signaling to 4E-BP1 only, or deletion of S6K1 alone, is not sufficient to reduce muscle hypertrophy or alter its sensitivity to rapamycin. However, we report that, while not required for muscle growth, S6K1 is essential for maintaining muscle structure and force production. Hypertrophy in the absence of S6K1 is characterized by compromised ribosome biogenesis and the formation of p62-positive protein aggregates. These findings identify S6K1 as a crucial player for maintaining muscle function during hypertrophy. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Developing Partnerships between Higher Education Faculty, K-12 Science Teachers, and School Administrators via MSP initiatives: The RITES Model

Science.gov (United States)

Caulkins, J. L.; Kortz, K. M.; Murray, D. P.

2011-12-01

The Rhode Island Technology Enhanced Science Project (RITES) is a NSF-funded Math and Science Partnership (MSP) project that seeks to improve science education. RITES is, at its core, a unique partnership that fosters relationships between middle and high school science teachers, district and school administrators, higher education (HE) faculty members, and science education researchers. Their common goal is to enhance scientific inquiry, increase classroom technology usage, and improve state level science test scores. In one of the more visible examples of this partnership, middle and high school science teachers work closely with HE science faculty partners to design and teach professional development (PD) workshops. The PD sessions focus on technology-enhanced scientific investigations (e.g. use of probes, online simulations, etc.), exemplify inquiry-based instruction, and relate expert content knowledge. Teachers from these sessions express substantial satisfaction in the program, report increased comfort levels in teaching the presented materials (both via post-workshop surveys), and show significant gains in content knowledge (via pre-post assessments). Other benefits to this kind of partnership, in which K-12 and HE teachers are considered equals, include: 1) K-12 teachers are empowered through interactions with HE faculty and other science teachers in the state; 2) HE instructors become more informed not only about good pedagogical practices, but also practical aspects of teaching science such as engaging students; and 3) the PD sessions tend to be much stronger than ones designed and presented solely by HE scientists, for while HE instructors provide content expertise, K-12 teachers provide expertise in K-12 classroom practice and implementation. Lastly, the partnership is mutually beneficial for the partners involved because both sides learn practical ways to teach science and inquiry at different levels. In addition to HE faculty and K-12 science teacher

Mobile STEMship Discovery Center: K-12 Aerospace-Based Science, Technology, Engineering, and Mathematics (STEM) Mobile Teaching Vehicle

Science.gov (United States)

2015-08-03

AND SUBTITLE Mobile STEMship Discovery Center: K-12 Aerospace-Based Science, Technology, Engineering, and Mathematics (STEM) Mobile Teaching Vehicle...Center program to be able to expose Science Technology, Engineering and Mathematics (STEM) space-inspired science centers for DC Metro beltway schools

NPA4K development system using object-oriented methodology

International Nuclear Information System (INIS)

Jeong, Kwang Seong; Hahn, Do Hee

2000-11-01

NPA4K consists of module programs with several components for various functions. Software components have to be developed systematically by compartment criteria and design method. In this paper, the understandings of a typical Object-Oriented Methodology , UML(Unified Modeling Language), the procedure for NPA4K program development and the architecture for long-term development of NPA4K are introduced

NPA4K development system using object-oriented methodology

Energy Technology Data Exchange (ETDEWEB)

Jeong, Kwang Seong; Hahn, Do Hee

2000-11-01

NPA4K consists of module programs with several components for various functions. Software components have to be developed systematically by compartment criteria and design method. In this paper, the understandings of a typical Object-Oriented Methodology , UML(Unified Modeling Language), the procedure for NPA4K program development and the architecture for long-term development of NPA4K are introduced.

Effects on atmospherics at 6 kHz and 9 kHz recorded at Tripura during the India-Pakistan Border earthquake

Directory of Open Access Journals (Sweden)

S. S. De

2010-04-01

Full Text Available The outcome of the results of some analyses of electromagnetic emissions recorded by VLF receivers at 6 kHz and 9 kHz over Agartala, Tripura, the North-Eastern state of India (Lat. 23° N, Long. 91.4° E during the large earthquake at Muzaffarabad (Lat. 34.53° N, Long. 73.58° E at Kashmir under Pakistan have been presented here. Spiky variations in integrated field intensity of atmospherics (IFIA at 6 and 9 kHz have been observed 10 days prior (from midnight of 28 September 2005 to the day of occurrence of the earthquake on 8 October 2005 and the effect continued, decayed gradually and eventually ceased on 16 October 2005. The spikes distinctly superimposed on the ambient level with mutual separation of 2–5 min. Occurrence number of spikes per hour and total duration of their occurrence have been found remarkably high on the day of occurrence of the earthquake. The spike heights are higher at 6 kHz than at 9 kHz. The results have been explained on the basis of generation of electromagnetic radiation associated with fracture of rocks, their subsequent penetration into the Earth's atmosphere and finally their propagation between Earth-ionosphere waveguide. The present observation shows that VLF anomaly is well-confined between 6 and 9 kHz.

Integrating Science Content and Pedagogy in the Earth, Life, and Physical Sciences: A K-8 Pre-Service Teacher Preparation Continuum at the University of Delaware

Science.gov (United States)

Madsen, J.; Allen, D.; Donham, R.; Fifield, S.; Ford, D.; Shipman, H.; Dagher, Z.

2007-12-01

University of Delaware faculty in the geological sciences, biological sciences, and the physics and astronomy departments have partnered with faculty and researchers from the school of education to form a continuum for K- 8 pre-service teacher preparation in science. The goal of the continuum is to develop integrated understandings of content and pedagogy so that these future teachers can effectively use inquiry-based approaches in teaching science in their classrooms. Throughout the continuum where earth science content appears an earth system science approach, with emphasis on inquiry-based activities, is employed. The continuum for K-8 pre-service teachers includes a gateway content course in the earth, life, or physical sciences taken during the freshman year followed by integrated science content and methods courses taken during the sophomore year. These integrated courses, called the Science Semester, were designed and implemented with funding from the National Science Foundation. During the Science Semester, traditional content and pedagogy subject matter boundaries are crossed to stress shared themes that teachers must understand to teach standards-based science. Students work collaboratively on multidisciplinary problem-based learning (PBL) activities that place science concepts in authentic contexts and build learning skills. They also critically explore the theory and practice of elementary science teaching, drawing on their shared experiences of inquiry learning during the Science Semester. The PBL activities that are the hallmark of the Science Semester provide the backdrop through which fundamental earth system interactions can be studied. For example in a PBL investigation that focuses on kids, cancer, and the environment, the hydrologic cycle with emphasis on surface runoff and ground water contamination is studied. Those students seeking secondary certification in science will enroll, as a bridge toward their student teaching experience, in an

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 126; Issue 6. How does fatty acid influence anti-thyroid drugs binding and specificity toward protein human serum albumin? A blind docking simulation study. Bijan K Paul Nikhil Guchhait. Regular Articles Volume 126 Issue 6 November 2014 pp 1929-1939 ...

Tech-Savvy Science Education? Understanding Teacher Pedagogical Practices for Integrating Technology in K-12 Classrooms

Science.gov (United States)

Hechter, Richard; Vermette, Laurie Anne

2014-01-01

This paper examines the technology integration practices of Manitoban K-12 inservice science educators based on the Technological, Pedagogical, and Content knowledge (TPACK) framework. Science teachers (n = 433) completed a 10-item online survey regarding pedagogical beliefs about technology integration, types of technology used, and how often…

Targeting Aberrant p70S6K Activation for Estrogen Receptor-Negative Breast Cancer Prevention.

Science.gov (United States)

Wang, Xiao; Yao, Jun; Wang, Jinyang; Zhang, Qingling; Brady, Samuel W; Arun, Banu; Seewaldt, Victoria L; Yu, Dihua

2017-11-01

The prevention of estrogen receptor-negative (ER-) breast cancer remains a major challenge in the cancer prevention field, although antiestrogen and aromatase inhibitors have shown adequate efficacy in preventing estrogen receptor-positive (ER + ) breast cancer. Lack of commonly expressed, druggable targets is a major obstacle for meeting this challenge. Previously, we detected the activation of Akt signaling pathway in atypical hyperplasic early-stage lesions of patients. In the current study, we found that Akt and the downstream 70 kDa ribosomal protein S6 kinase (p70S6K) signaling pathway was highly activated in ER - premalignant breast lesions and ER - breast cancer. In addition, p70S6K activation induced transformation of ER - human mammary epithelial cells (hMEC). Therefore, we explored the potential of targeting Akt/p70S6K in the p70S6K activated, ER - hMEC models and mouse mammary tumor models for the prevention of ER - breast cancer. We found that a clinically applicable Akt/p70S6K dual inhibitor, LY2780301, drastically decreased proliferation of hMECs with ErbB2-induced p70S6K activation via Cyclin B1 inhibition and cell-cycle blockade at G 0 -G 1 phase, while it did not significantly reverse the abnormal acinar morphology of these hMECs. In addition, a brief treatment of LY2780301 in MMTV- neu mice that developed atypical hyperplasia (ADH) and mammary intraepithelial neoplasia (MIN) lesions with activated p70S6K was sufficient to suppress S6 phosphorylation and decrease cell proliferation in hyperplasic MECs. In summary, targeting the aberrant Akt/p70S6K activation in ER - hMEC models in vitro and in the MMTV- neu transgenic mouse model in vivo effectively inhibited Akt/S6K signaling and reduced proliferation of hMECs in vitro and ADH/MIN lesions in vivo , indicating its potential in prevention of p70S6K activated ER - breast cancer. Cancer Prev Res; 10(11); 641-50. ©2017 AACR . ©2017 American Association for Cancer Research.

On two-particle N=1 supersymmetric composite grand unified models

International Nuclear Information System (INIS)

Pirogov, Yu.F.

1984-01-01

A class of two-particle N=1 supersymmetric composite grand unified models, satisfying the anomaly matching and cancellation conditions, n-independence and survival hypothesis is considered. A unique admissible set of the light states, containing spectator states on a par with the composite ones is found. At low mass scales this set contains exactly four families of ordinary fermions without any additional exotics. The interactions of the light states at distances greater than the compositeness radius are described by the N=1 sypersymmetric chiral grand unified model [SU(6)] 2 (or [SU(8)] 2 with a fixed set of four second-rank tensors as matter fields

CP violation in rare K decays

International Nuclear Information System (INIS)

Ecker, G.

1990-01-01

The investigation of rare K decays calls for a unified treatment of short- and long-distance aspects as provided by chiral perturbation theory. For the standard model with three generations, the theoretical predictions for signals of CP violation in those decays are reviewed. With direct CP violation as the main target, special emphasis is given to the charge asymmetries in charged K decays and to the especially rare decays K L → π 0 ll-bar. Time dependent rate asymmetries in K 0 decays and the longitudinal muon polarization in K L → μ + μ - are also discussed. 50 refs., 3 figs., 1 tab. (Author)

The unified theory of nuclear reactions

International Nuclear Information System (INIS)

Tobocman, W.

A unified nuclear reaction theory is a formalism for the scattering reactions of many-body nuclear systems which is capable of describing both direct interaction and compound nucleus formation processes. The Feshbach projection operator formalism is the original unified nuclear reaction theory. An alternative unified nuclear reaction theory called the X-matrix formalism is described. The X-matrix formalism is a generalization of the Brown-de Dominicis formalism. It does not require projection operators and is readly applied to rearrangement collisions

Hsp60 and p70S6K form a complex in human cardiomyocytes

Directory of Open Access Journals (Sweden)

Kroupskaya I. V.

2011-02-01

Full Text Available Molecular chaperon Hsp60 and protein kinase p70S6K play an important functional role in the regulation of cardiomyocytes vital function or apoptosis. Aim. To study a possibility of in vivo complex formation between Hsp60 and p70S6K in cardiomyocytes. Methods. Co-immunoprecipitation, Western-blot analysis. Results. We have identified in vivo interaction between molecular chaperone Hsp60 and two isoforms of proteinkinase p70S6K in human myocardium, normal and affected by cardiomyopathy. Conclusions. The results obtained suggest a possible participation of molecular chaperon Hsp60 in regulation of p70S6K activity in stressinduced apoptotic signaling pathway in cardiomyocytes.

Grand unified theories. Pt. 2

International Nuclear Information System (INIS)

Ellis, J.

1982-01-01

The author gives an introduction to the construction of grand unified theories on the base of the SU(3)xSU(2)xU(1) model of the strong, weak, and electromagnetic interactions. Especially he discusses the proton decay, neutrino masses and oscillations, and cosmological implications in connection with grand unified theories. (orig./HSI)

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Chemical Sciences; Volume 114; Issue 6. An immunomodulator from Tinospora cordifolia with antioxidant activity in cell-free systems. Veena R Desai J P Kamat K B Sainis. Volume 114 Issue 6 December 2002 pp 713-719 ...

Direction: unified theory of interactions

International Nuclear Information System (INIS)

Valko, P.

1987-01-01

Briefly characterized are the individual theories, namely, the general relativity theory, the Kaluza-Klein theory, the Weyl theory, the unified theory of electromagnetic and weak interactions, the supergravity theory, and the superstring theory. The history is recalled of efforts aimed at creating a unified theory of interactions, and future prospects are outlined. (M.D.). 2 figs

A 6 kW at 4.5 K helium refrigerator for CERN's Cryogenic Test Station

International Nuclear Information System (INIS)

Gistau, G.M.; Bonneton, M.

1994-01-01

For purposes of testing the present LEP superconducting resonant cavities and the future LHC magnets, CERN built a test station the cryogenic power of which is presently supplied by a dedicated 6 kW at 4.5 K helium refrigerator. The thermodynamic cycle is discussed and special emphasis is put on a new cryogenic expansion turbine operating in the liquid phase. Information is given about: the cycle screw compressors' performances, the general performance of the refrigerator, the expected efficiency enhancement due to the liquid turbine, an off-design turn down operation

Self-Assembling Peptide Surfactants A6K and A6D Adopt a-Helical Structures Useful for Membrane Protein Stabilization

Directory of Open Access Journals (Sweden)

Furen Zhuang

2011-10-01

Full Text Available Elucidation of membrane protein structures have been greatly hampered by difficulties in producing adequately large quantities of the functional protein and stabilizing them. A6D and A6K are promising solutions to the problem and have recently been used for the rapid production of membrane-bound G protein-coupled receptors (GPCRs. We propose that despite their short lengths, these peptides can adopt α-helical structures through interactions with micelles formed by the peptides themselves. These α-helices are then able to stabilize α-helical motifs which many membrane proteins contain. We also show that A6D and A6K can form β-sheets and appear as weak hydrogels at sufficiently high concentrations. Furthermore, A6D and A6K together in sodium dodecyl sulfate (SDS can form expected β-sheet structures via a surprising α-helical intermediate.

CESAME: Providing High Quality Professional Development in Science and Mathematics for K-12 Teachers

Science.gov (United States)

Hickman, Paul

2002-04-01

It is appropriate that after almost half a century of Science and Mathematics education reform we take a look back and a peek forward to understand the present state of this wonderfully complex system. Each of the components of this system including teaching, professional development, assessment, content and the district K-12 curriculum all need to work together if we hope to provide quality science, mathematics and technology education for ALL students. How do the state and national standards drive the system? How do state policies on student testing and teacher licensure come into play? How do we improve the preparation, retention and job satisfaction of our K-12 teachers? What initiatives have made or are making a difference? What else needs to be done? What can the physics community do to support local efforts? This job is too big for any single organization or individual but we each can contribute to the effort. Our Center at Northeastern University, with support from the National Science Foundation, has a sharply defined focus: to get high quality, research-based instructional materials into the hands of K-12 classroom teachers and provide the support they need to use the materials effectively in their classrooms.

D K Mishra

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. D K Mishra. Articles written in Bulletin of Materials Science. Volume 34 Issue 7 December 2011 pp 1501-1506. Ce-doped LCMO CMR manganites: a consequence of enhanced T c and T IM · D K Mishra D R Sahu P K Mishra S K Singh B K Mohapatra B K Roul · More Details ...

A Product Line Enhanced Unified Process

DEFF Research Database (Denmark)

Zhang, Weishan; Kunz, Thomas

2006-01-01

The Unified Process facilitates reuse for a single system, but falls short handling multiple similar products. In this paper we present an enhanced Unified Process, called UPEPL, integrating the product line technology in order to alleviate this problem. In UPEPL, the product line related activit...... activities are added and could be conducted side by side with other classical UP activities. In this way both the advantages of Unified Process and software product lines could co-exist in UPEPL. We show how to use UPEPL with an industrial mobile device product line in our case study....

R K Laxman

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. R K Laxman. Articles written in Resonance – Journal of Science Education. Volume 1 Issue 4 April 1996 pp 4-4 Science Smiles. Chief Editor's column / Science Smiles · R K Laxman · More Details Fulltext PDF. Volume 1 Issue 5 May 1996 pp 3-3 Science Smiles.

An urban area minority outreach program for K-6 children in space science

Science.gov (United States)

Morris, P.; Garza, O.; Lindstrom, M.; Allen, J.; Wooten, J.; Sumners, C.; Obot, V.

The Houston area has minority populations with significant school dropout rates. This is similar to other major cities in the United States and elsewhere in the world where there are significant minority populations from rural areas. The student dropout rates are associated in many instances with the absence of educational support opportuni- ties either from the school and/or from the family. This is exacerbated if the student has poor English language skills. To address this issue, a NASA minority university initiative enabled us to develop a broad-based outreach program that includes younger children and their parents at a primarily Hispanic inner city charter school. The pro- gram at the charter school was initiated by teaching computer skills to the older chil- dren, who in turn taught parents. The older children were subsequently asked to help teach a computer literacy class for mothers with 4-5 year old children. The computers initially intimidated the mothers as most had limited educational backgrounds and En- glish language skills. To practice their newly acquired computer skills and learn about space science, the mothers and their children were asked to pick a space project and investigate it using their computer skills. The mothers and their children decided to learn about black holes. The project included designing space suits for their children so that they could travel through space and observe black holes from a closer proxim- ity. The children and their mothers learned about computers and how to use them for educational purposes. In addition, they learned about black holes and the importance of space suits in protecting astronauts as they investigated space. The parents are proud of their children and their achievements. By including the parents in the program, they have a greater understanding of the importance of their children staying in school and the opportunities for careers in space science and technology. For more information on our overall

The Unified Astronomy Thesaurus: Semantic Metadata for Astronomy and Astrophysics

Science.gov (United States)

Frey, Katie; Accomazzi, Alberto

2018-05-01

Several controlled vocabularies have been developed and used by the astronomical community, each designed to serve a specific need and a specific group. The Unified Astronomy Thesaurus (UAT) attempts to provide a highly structured controlled vocabulary that will be relevant and useful across the entire discipline, regardless of content or platform. Because classifying articles and data will be the two major functions of the UAT, we examine the UAT in comparison with the Astronomical Subject Keywords used by major publications and the JWST Science Keywords used by STScI’s Astronomer’s Proposal Tool.

Y K Vijay

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Y K Vijay. Articles written in Bulletin of Materials Science. Volume 27 Issue 5 October 2004 pp 417-420 Nuclear Related Materials. Irradiation of large area Mylar membrane and characterization of nuclear track filter · N K Acharya P K Yadav S Wate Y K Vijay F Singh D K Avasthi.

Cromatografia unificada Unified chromatography

Directory of Open Access Journals (Sweden)

Carin von Mühlen

2004-10-01

Full Text Available The scope of this study encompasses an overview of the principles of unified chromatography as well as the principles of chromatographic techniques as applied to unified systems, which include gas chromatography, liquid chromatography, supercritical fluid chromatography, high temperature and high pressure liquid chromatography, micro-liquid chromatography, enhanced fluidity chromatography, and solvating gas chromatography. Theoretical considerations and individual instrumental parameters such as mobile phase, sample introduction system, columns, and detection system are also discussed. Future applications of this separation approach are discussed.

elements of contemporary integrated science curriculum

African Journals Online (AJOL)

both science and technology (Hurd, 1975). Discoveries in nature are made easier through integration of ideas, thoughts and concepts. To this end, science teaching in the modern world ought to be interdisciplinary, unified, society based and aspire above all to achieve scientific literacy (Arokoyu and Dike, 2009). These are.

Children and Exercise: Appropriate Practices for Grades K-6

Science.gov (United States)

Fisher, Michele

2009-01-01

Growth and development have a profound effect on physical fitness, response to exercise, and exercise programming in children. This article reviews the essential pediatric exercise physiology concepts relevant to physical education programs for K-6 children. Indices of physical fitness such as cardiorespiratory endurance, muscular strength, and…

Low Frequency Plasma Oscillations in a 6-kW Magnetically Shielded Hall Thruster

Science.gov (United States)

Jorns, Benjamin A.; Hofery, Richard R.

2013-01-01

The oscillations from 0-100 kHz in a 6-kW magnetically shielded thruster are experimen- tally characterized. Changes in plasma parameters that result from the magnetic shielding of Hall thrusters have the potential to significantly alter thruster transients. A detailed investigation of the resulting oscillations is necessary both for the purpose of determin- ing the underlying physical processes governing time-dependent behavior in magnetically shielded thrusters as well as for improving thruster models. In this investigation, a high speed camera and a translating ion saturation probe are employed to examine the spatial extent and nature of oscillations from 0-100 kHz in the H6MS thruster. Two modes are identified at 8 kHz and 75-90 kHz. The low frequency mode is azimuthally uniform across the thruster face while the high frequency oscillation is concentrated close to the thruster centerline with an m = 1 azimuthal dependence. These experimental results are discussed in the context of wave theory as well as published observations from an unshielded variant of the H6MS thruster.

The 6th International Earth Science Olympiad: A Student Perspective

Science.gov (United States)

Barlett, Luke; Cathro, Darcy; Mellow, Maddi; Tate, Clara

2014-01-01

In October 2012, two students from the Australian Science and Mathematics School and two from Yankalilla Area School were selected to travel to Olavarria, Argentina in order to compete in the 6th International Earth Science Olympiad (IESO). It was an opportunity for individuals with a passion for Earth science to come together from 17 countries to…

Molecular catalysis science: Perspective on unifying the fields of catalysis.

Science.gov (United States)

Ye, Rong; Hurlburt, Tyler J; Sabyrov, Kairat; Alayoglu, Selim; Somorjai, Gabor A

2016-05-10

Colloidal chemistry is used to control the size, shape, morphology, and composition of metal nanoparticles. Model catalysts as such are applied to catalytic transformations in the three types of catalysts: heterogeneous, homogeneous, and enzymatic. Real-time dynamics of oxidation state, coordination, and bonding of nanoparticle catalysts are put under the microscope using surface techniques such as sum-frequency generation vibrational spectroscopy and ambient pressure X-ray photoelectron spectroscopy under catalytically relevant conditions. It was demonstrated that catalytic behavior and trends are strongly tied to oxidation state, the coordination number and crystallographic orientation of metal sites, and bonding and orientation of surface adsorbates. It was also found that catalytic performance can be tuned by carefully designing and fabricating catalysts from the bottom up. Homogeneous and heterogeneous catalysts, and likely enzymes, behave similarly at the molecular level. Unifying the fields of catalysis is the key to achieving the goal of 100% selectivity in catalysis.

Unified Access Architecture for Large-Scale Scientific Datasets

Science.gov (United States)

Karna, Risav

2014-05-01

data formats have been anticipated and considered during the design of the unified architecture. The research focuses on the feasibility of the designed coupling mechanism and the evaluation of the efficiency and benefits of our proposed unified access architecture. Zhang 2011: Zhang, Ying and Kersten, Martin and Ivanova, Milena and Nes, Niels, SciQL: Bridging the Gap Between Science and Relational DBMS, Proceedings of the 15th Symposium on International Database Engineering Applications, 2011. Baumann 98: Baumann, P., Dehmel, A., Furtado, P., Ritsch, R., Widmann, N., "The Multidimensional Database System RasDaMan", SIGMOD 1998, Proceedings ACM SIGMOD International Conference on Management of Data, June 2-4, 1998, Seattle, Washington, 1998. hadoop1: hadoop.apache.org, "Hadoop", http://hadoop.apache.org/, [Online; accessed 12-Jan-2014]. scalapack1: netlib.org/scalapack, "ScaLAPACK", http://www.netlib.org/scalapack,[Online; accessed 12-Jan-2014]. r1: r-project.org, "R", http://www.r-project.org/,[Online; accessed 12-Jan-2014]. matlab1: mathworks.com, "Matlab Documentation", http://www.mathworks.de/de/help/matlab/,[Online; accessed 12-Jan-2014]. scidbusr1: scidb.org, "SciDB User's Guide", http://scidb.org/HTMLmanual/13.6/scidb_ug,[Online; accessed 01-Dec-2013].

Group theory for unified model building

International Nuclear Information System (INIS)

Slansky, R.

1981-01-01

The results gathered here on simple Lie algebras have been selected with attention to the needs of unified model builders who study Yang-Mills theories based on simple, local-symmetry groups that contain as a subgroup the SUsup(w) 2 x Usup(w) 1 x SUsup(c) 3 symmetry of the standard theory of electromagnetic, weak, and strong interactions. The major topics include, after a brief review of the standard model and its unification into a simple group, the use of Dynkin diagrams to analyze the structure of the group generators and to keep track of the weights (quantum numbers) of the representation vectors; an analysis of the subgroup structure of simple groups, including explicit coordinatizations of the projections in weight space; lists of representations, tensor products and branching rules for a number of simple groups; and other details about groups and their representations that are often helpful for surveying unified models, including vector-coupling coefficient calculations. Tabulations of representations, tensor products, and branching rules for E 6 , SO 10 , SU 6 , F 4 , SO 9 , SO 5 , SO 8 , SO 7 , SU 4 , E 7 , E 8 , SU 8 , SO 14 , SO 18 , SO 22 , and for completeness, SU 3 are included. (These tables may have other applications.) Group-theoretical techniques for analyzing symmetry breaking are described in detail and many examples are reviewed, including explicit parameterizations of mass matrices. (orig.)

Meteorology--An Interdisciplinary Base for Science Learning.

Science.gov (United States)

Howell, David C.

1980-01-01

Described is a freshman science program at Deerfield Academy (Deerfield, Mass.) in meteorology, designed as the first part of a three-year unified science sequence. Merits of the course, in which particular emphasis is placed on observation skills and making predictions, are enumerated. (CS)

K--12 science educator perception of instructing students with learning disabilities in the regular classroom

Science.gov (United States)

Holliday-Cashwell, Janet Rose

2000-10-01

Selected K--12 public school science educators in 14 eastern North Carolina counties were surveyed to examine their perceptions of their undergraduate preparation programs with regard to instructing students with learning disabilities in the regular classroom. A quantitative study, this research examined science educator preparedness in instructing students with learning disabilities by evaluating educator perception in regard to mainstrearned and inclusive educational settings. Specifically, two null hypotheses were tested. Null hypothesis I stated a significant difference does not exist between selected North Carolina K--12 science educators' perceptions of their undergraduate teacher education preparation programs and their perceptions of their abilities to instruct students needing accommodations on behalf of their learning disabilities in mainstrearned or inclusive settings. Participants' responses to perception as well as value statements regarding opinions, adaptations, and undergraduate training with respect to mainstreaming and inclusion were evaluated through t-test analyses of 22 Likert-scale items. Null hypothesis 1 was not accepted because a statistically significant difference did exist between the educators' perceptions of their undergraduate training and their perceived abilities to instruct students with learning disabilities in mainstreamed or inclusive settings. Null hypothesis 2 stated a significant difference does not exist between selected North Carolina K--12 science educators' attained educational level; grade level currently taught, supervised or chaired; and years of experience in teaching science, supervising science education, and/or chairing science departments in selected North Carolina public schools and their opinions of their undergraduate teacher education program with regard to instructing students with learning disabilities in mainstreamed or inclusive educational settings. Null hypothesis 2 was evaluated through an analysis of

Ocean Sciences Sequence for Grades 6-8: Climate Change Curriculum Developed Through a Collaboration Between Scientists and Educators

Science.gov (United States)

Weiss, E.; Skene, J.; Tran, L.

2011-12-01

aligns with the Ocean Literacy and Climate Literacy Frameworks, as well as multiple core ideas in the new National Academy of Sciences Framework for K-12 Science Education. In brief, the curriculum comprises 33 45-minute sessions organized into three thematic units that are each driven by an exploratory question: Unit 1 (11 sessions)-How do the ocean and atmosphere interact?; Unit 2 (8 sessions)-How does carbon flow through the ocean, land, and atmosphere?; and Unit 3 (12 sessions)-What are the causes and effects of climate change? The curriculum deliberately explores the ocean and climate as global systems, and challenges students to use scientific evidence to make explanations about climate change. The Ocean Sciences Sequence for Grades 6-8 is currently being classroom tested by teachers across the United States in a wide variety of classroom settings. Evaluation is also being undertaken to determine the efficacy of the sequence in addressing the curriculum's learning goals.

R K Mangal

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. R K Mangal. Articles written in Bulletin of Materials Science. Volume 29 Issue 7 December 2006 pp 653-657 Semiconductors. Preparation of Al–Sb semiconductor by swift heavy ion irradiation · R K Mangal M Singh Y K Vijay D K Avasthi · More Details Abstract Fulltext PDF.

The free-energy principle: a unified brain theory?

Science.gov (United States)

Friston, Karl

2010-02-01

A free-energy principle has been proposed recently that accounts for action, perception and learning. This Review looks at some key brain theories in the biological (for example, neural Darwinism) and physical (for example, information theory and optimal control theory) sciences from the free-energy perspective. Crucially, one key theme runs through each of these theories - optimization. Furthermore, if we look closely at what is optimized, the same quantity keeps emerging, namely value (expected reward, expected utility) or its complement, surprise (prediction error, expected cost). This is the quantity that is optimized under the free-energy principle, which suggests that several global brain theories might be unified within a free-energy framework.

Unified universal quantum cloning machine and fidelities

Energy Technology Data Exchange (ETDEWEB)

Wang Yinan; Shi Handuo; Xiong Zhaoxi; Jing Li; Mu Liangzhu [School of Physics, Peking University, Beijing 100871 (China); Ren Xijun [School of Physics and Electronics, Henan University, Kaifeng 4750011 (China); Fan Heng [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)

2011-09-15

We present a unified universal quantum cloning machine, which combines several different existing universal cloning machines together, including the asymmetric case. In this unified framework, the identical pure states are projected equally into each copy initially constituted by input and one half of the maximally entangled states. We show explicitly that the output states of those universal cloning machines are the same. One importance of this unified cloning machine is that the cloning procession is always the symmetric projection, which reduces dramatically the difficulties for implementation. Also, it is found that this unified cloning machine can be directly modified to the general asymmetric case. Besides the global fidelity and the single-copy fidelity, we also present all possible arbitrary-copy fidelities.

Nikkaji Dictionary: 6α-ヒドロキシテストステロン [MeCab user dictionary for science technology term[Archive

Lifescience Database Archive (English)

Full Text Available MeCab user dictionary for science technology term 6α-ヒドロキシテストステロン 名詞 一般 * * * * 6α-ヒドロキシテスト...ステロン ... Nikkaji J239.112K 200906081381561700 C CA06 UNKNOWN_2 6 α - ヒドロキシテストステロン

1:6,000 Grid of Louisiana, Geographic NAD83, LGS (2007) [quad6k_losco_2007

Data.gov (United States)

Louisiana Geographic Information Center — This "QUAD6K_LOSCO_2007" ploygon shapefile is a reference index to the polygon footprints of quarters of the Digital Orthographic Quarter Quadrangles (DOQQs), or...

Introduction to unified theories of weak, electromagnetic and strong interactions - SU(5)

International Nuclear Information System (INIS)

Billoire, Alain; Morel, Andre.

1980-11-01

These notes correspond to a series of lectures given at Salay during winter 1979-1980. They are meant to be an introduction to the so-called grand unified theories of weak, electromagnetic and strong interactions. In a first part, we recall in a very elementary way the standard SU(2) model of electroweak interactions, putting the emphasis on the questions which are left open by this model and which unified theories help to answer. In part II, we explain in a systematic way how unified theories can be constructed, and develop the SU(5) model in great detail. Other models, like SO(10) and E 6 , are not presented, because SU(5) is the simplest one and has been subject to the deepest investigations up to now. Also it appears that most concepts and general results are not specific to any particular symmetry group [fr

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. D K Saxena. Articles written in Resonance – Journal of Science Education. Volume 9 Issue 6 June 2004 pp 56-65 General Article. Uses of Bryophytes · D K Saxena Harinder · More Details Fulltext PDF ...

Grand unified models including extra Z bosons

International Nuclear Information System (INIS)

Li Tiezhong

1989-01-01

The grand unified theories (GUT) of the simple Lie groups including extra Z bosons are discussed. Under authors's hypothesis there are only SU 5+m SO 6+4n and E 6 groups. The general discussion of SU 5+m is given, then the SU 6 and SU 7 are considered. In SU 6 the 15+6 * +6 * fermion representations are used, which are not same as others in fermion content, Yukawa coupling and broken scales. A conception of clans of particles, which are not families, is suggested. These clans consist of extra Z bosons and the corresponding fermions of the scale. The all of fermions in the clans are down quarks except for the standard model which consists of Z bosons and 15 fermions, therefore, the spectrum of the hadrons which are composed of these down quarks are different from hadrons at present

K2-141 b. A 5-M⊕ super-Earth transiting a K7 V star every 6.7 h

Science.gov (United States)

Barragán, O.; Gandolfi, D.; Dai, F.; Livingston, J.; Persson, C. M.; Hirano, T.; Narita, N.; Csizmadia, Sz.; Winn, J. N.; Nespral, D.; Prieto-Arranz, J.; Smith, A. M. S.; Nowak, G.; Albrecht, S.; Antoniciello, G.; Bo Justesen, A.; Cabrera, J.; Cochran, W. D.; Deeg, H.; Eigmuller, Ph.; Endl, M.; Erikson, A.; Fridlund, M.; Fukui, A.; Grziwa, S.; Guenther, E.; Hatzes, A. P.; Hidalgo, D.; Johnson, M. C.; Korth, J.; Palle, E.; Patzold, M.; Rauer, H.; Tanaka, Y.; Van Eylen, V.

2018-05-01

We report on the discovery of K2-141 b (EPIC 246393474 b), an ultra-short-period super-Earth on a 6.7 h orbit transiting an active K7 V star based on data from K2 campaign 12. We confirmed the planet's existence and measured its mass with a series of follow-up observations: seeing-limited MuSCAT imaging, NESSI high-resolution speckle observations, and FIES and HARPS high-precision radial-velocity monitoring. K2-141 b has a mass of 5.31 ± 0.46 M⊕ and radius of 1.54-0.09+0.10 R⊕, yielding a mean density of 8.00-1.45+1.83 g cm-3 and suggesting a rocky-iron composition. Models indicate that iron cannot exceed 70% of the total mass. With an orbital period of only 6.7 h, K2-141 b is the shortest-period planet known to date with a precisely determined mass. Based on observations obtained with (a) the Nordic Optical Telescope (NOT), operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos (ORM) of the Instituto de Astrofisica de Canarias (IAC); (b) the 3.6m ESO telescope at La Silla Observatory under program ID 099.C-0491; (c) the Kepler space telescope in its extended mission K2.Tables of the light curve data and the radial velocities are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/612/A95

Proceedings of the 6. Japan-Brazil Symposium on Science and Technology

International Nuclear Information System (INIS)

1988-01-01

The most recent results of Brazil-Japan agreement for technological development on areas of space science and plasma, were presented. Problems related to: astrophysics, cosmic radiation interaction with earth atmosphere, plasma physics, and construction of rockets and satellites for space researches were discussed. (M.C.K.) [pt

Complete cDNA sequence and amino acid analysis of a bovine ribonuclease K6 gene.

Science.gov (United States)

Pietrowski, D; Förster, M

2000-01-01

The complete cDNA sequence of a ribonuclease k6 gene of Bos Taurus has been determined. It codes for a protein with 154 amino acids and contains the invariant cysteine, histidine and lysine residues as well as the characteristic motifs specific to ribonuclease active sites. The deduced protein sequence is 27 residues longer than other known ribonucleases k6 and shows amino acids exchanges which could reflect a strain specificity or polymorphism within the bovine genome. Based on sequence similarity we have termed the identified gene bovine ribonuclease k6 b (brk6b).

K B Shaik

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K B Shaik. Articles written in Resonance – Journal of Science Education. Volume 15 Issue 3 March 2010 pp 257-267 Classroom. Chaos from Jerk Circuit · K B Shaik M K Mandal · More Details Fulltext PDF ...

Linear thermal expansion measurements on silicon from 6 to 340 K

International Nuclear Information System (INIS)

Lyon, K.G.; Salinger, G.L.; Swenson, C.A.; White, G.K.

1977-01-01

Linear thermal expansion measurements have been carried out from 6 to 340 K on a high-purity silicon sample using a linear absolute capacitance dilatometer. The accuracy of the measurements varies from +- 0.01 x 10 -8 K -1 at the lowest temperatures to +- 0.1 x 10 -8 K -1 or 0.1%, whichever is greater, near room temperature, and is sufficient to establish silicon as a thermal expansion standard for these temperatures. The agreement with previous data is satisfactory at low temperatures and excellent above room temperature where laser-interferometry data of comparable accuracy exist. Thermal expansions calculated from ultrasonic and heat-capacity data are preferred below 13 K where experimental problems occurred

Unified Approach in the DSS Development Process

Directory of Open Access Journals (Sweden)

2007-01-01

Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

Problem-Based Learning in the Earth and Space Science Classroom, K-12

Science.gov (United States)

McConnell, Tom J.; Parker, Joyce; Eberhardt, Janet

2017-01-01

If you've ever asked yourself whether problem-based learning (PBL) can bring new life to both your teaching and your students' learning, here's your answer: Yes. This all-in-one guide will help you engage your students in scenarios that represent real-world science in all its messy, thought-provoking glory. The scenarios will prompt K-12 students…

76 FR 36951 - In the Matter of Animal Cloning Sciences, Inc. (n/k/a Bancorp Energy, Inc.): Order of Suspension...

Science.gov (United States)

2011-06-23

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] In the Matter of Animal Cloning Sciences, Inc. (n/k/a Bancorp Energy, Inc.): Order of Suspension of Trading June 21, 2011. It appears to the... securities of Animal Cloning Sciences, Inc. (n/k/a Bancorp Energy, Inc.) because it has not filed any...

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

Directory of Open Access Journals (Sweden)

Yutaka Kurebayashi

2012-04-01

Full Text Available The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4+ T cells upon stimulation through TCR and CD28. Here, we demonstrate that the suppression of this axis by deletion of p85α or PI3K/mTORC1 inhibitors as well as T cell-specific deletion of raptor, an essential component of mTORC1, impairs Th17 differentiation in vitro and in vivo in a S6K1/2-dependent fashion. Inhibition of PI3K-Akt-mTORC1-S6K1 axis impairs the downregulation of Gfi1, a negative regulator of Th17 differentiation. Furthermore, we demonstrate that S6K2, a nuclear counterpart of S6K1, is induced by the PI3K-Akt-mTORC1 axis, binds RORγ, and carries RORγ to the nucleus. These results point toward a pivotal role of PI3K-Akt-mTORC1-S6K1/2 axis in Th17 differentiation.

LDA-Based Unified Topic Modeling for Similar TV User Grouping and TV Program Recommendation.

Science.gov (United States)

Pyo, Shinjee; Kim, Eunhui; Kim, Munchurl

2015-08-01

Social TV is a social media service via TV and social networks through which TV users exchange their experiences about TV programs that they are viewing. For social TV service, two technical aspects are envisioned: grouping of similar TV users to create social TV communities and recommending TV programs based on group and personal interests for personalizing TV. In this paper, we propose a unified topic model based on grouping of similar TV users and recommending TV programs as a social TV service. The proposed unified topic model employs two latent Dirichlet allocation (LDA) models. One is a topic model of TV users, and the other is a topic model of the description words for viewed TV programs. The two LDA models are then integrated via a topic proportion parameter for TV programs, which enforces the grouping of similar TV users and associated description words for watched TV programs at the same time in a unified topic modeling framework. The unified model identifies the semantic relation between TV user groups and TV program description word groups so that more meaningful TV program recommendations can be made. The unified topic model also overcomes an item ramp-up problem such that new TV programs can be reliably recommended to TV users. Furthermore, from the topic model of TV users, TV users with similar tastes can be grouped as topics, which can then be recommended as social TV communities. To verify our proposed method of unified topic-modeling-based TV user grouping and TV program recommendation for social TV services, in our experiments, we used real TV viewing history data and electronic program guide data from a seven-month period collected by a TV poll agency. The experimental results show that the proposed unified topic model yields an average 81.4% precision for 50 topics in TV program recommendation and its performance is an average of 6.5% higher than that of the topic model of TV users only. For TV user prediction with new TV programs, the average

Towards a unified developments of cluster science

International Nuclear Information System (INIS)

Wang Guanghou

1998-01-01

In the development of cluster science many concepts and methods have been introduced from nuclear physics, condensed matter physics and quantum chemistry, forming an interdisciplinary field between atomic and molecular physics on the one hand and condensed matter physics on the other hand. Recent achievements in the study of the structures and properties of clusters are reviewed in comparison with those of nuclei and quantum dots

D K Banerjee

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. D K Banerjee. Articles written in Resonance – Journal of Science Education. Volume 18 Issue 2 February 2013 pp 188-193 Classics. On the Stereoselective Synthesis of Oestrone · D K Banerjee K M Sivanandaiah · More Details Fulltext PDF ...

Ba2NiOsO6 : A Dirac-Mott insulator with ferromagnetism near 100 K

International Nuclear Information System (INIS)

Feng, Hai L.; Calder, Stuart

2016-01-01

In this study, the ferromagnetic semiconductor Ba 2 NiOsO 6 (T mag ~ 100 K) was synthesized at 6 GPa and 1500 °C. It crystallizes into a double perovskite structure [Fm - 3m; a = 8.0428 (1) Å], where the Ni 2+ and Os 6+ ions are perfectly ordered at the perovskite B site. We show that the spin-orbit coupling of Os 6+ plays an essential role in opening the charge gap. The magnetic state was investigated by density functional theory calculations and powder neutron diffraction. The latter revealed a collinear ferromagnetic order in a > 21 kOe magnetic field at 5 K. The ferromagnetic gapped state is fundamentally different from that of known dilute magnetic semiconductors such as (Ga,Mn)As and (Cd,Mn)Te (T mag < 180 K), the spin-gapless semiconductor Mn 2 CoAl (T mag ~ 720 K), and the ferromagnetic insulators EuO (T mag ~ 70 K) and Bi 3 Cr 3 O 11 (T mag ~ 220 K). It is also qualitatively different from known ferrimagnetic insulators and semiconductors, which are characterized by an antiparallel spin arrangement. Our finding of the ferromagnetic semiconductivity of Ba 2 NiOsO 6 should increase interest in the platinum group oxides, because this alternative class of materials should be useful in the development of spintronic, quantum magnetic, and related devices.

Elements of Contemporary Integrated Science Curriculum: Impacts ...

African Journals Online (AJOL)

This paper acknowledged the vital roles played by integration of ideas and established the progress brought about when science is taught as a unified whole through knowledge integration which birthed integrated science as a subject in Nigerian school curriculum. The efforts of interest groups at regional, national and ...

A Unified Grand Tour of Theoretical Physics

CERN Document Server

Lawrie, Ian D

2002-01-01

A unified account of the principles of theoretical physics, A Unified Grand Tour of Theoretical Physics, Second Edition stresses the inter-relationships between areas that are usually treated as independent. The profound unifying influence of geometrical ideas, the powerful formal similarities between statistical mechanics and quantum field theory, and the ubiquitous role of symmetries in determining the essential structure of physical theories are emphasized throughout.This second edition conducts a grand tour of the fundamental theories that shape our modern understanding of the physical wor

K Girigowda

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K Girigowda. Articles written in Resonance – Journal of Science Education. Volume 10 Issue 11 November 2005 pp 79-84 Classroom. Loading Effects on Resolution in Thin Layer Chromatography and Paper Chromatography · K Girigowda V H Mulimani.

Enhanced hydrogen storage properties of MgH2 co-catalyzed with K2NiF6 and CNTs.

Science.gov (United States)

Sulaiman, N N; Ismail, M

2016-12-06

The composite of MgH 2 /K 2 NiF 6 /carbon nanotubes (CNTs) is prepared by ball milling, and its hydrogenation properties are studied for the first time. MgH 2 co-catalyzed with K 2 NiF 6 and CNTs exhibited an improvement in the onset dehydrogenation temperature and isothermal de/rehydrogenation kinetics compared with the MgH 2 -K 2 NiF 6 composite. The onset dehydrogenation temperature of MgH 2 doped with 10 wt% K 2 NiF 6 and 5 wt% CNTs is 245 °C, which demonstrated a reduction of 25 °C compared with the MgH 2 + 10 wt% K 2 NiF 6 composite. In terms of rehydrogenation kinetics, MgH 2 doped with 10 wt% K 2 NiF 6 and 5 wt% CNTs samples absorbed 3.4 wt% of hydrogen in 1 min at 320 °C, whereas the MgH 2 + 10 wt% K 2 NiF 6 sample absorbed 2.6 wt% of hydrogen under the same conditions. For dehydrogenation kinetics at 320 °C, the MgH 2 + 10 wt% K 2 NiF 6 + 5 wt% CNTs sample released 3.3 wt% hydrogen after 5 min of dehydrogenation. By contrast, MgH 2 doped with 10 wt% K 2 NiF 6 released 3.0 wt% hydrogen in the same time period. The apparent activation energy, E a , for the dehydrogenation of MgH 2 doped with 10 wt% K 2 NiF 6 reduced from 100.0 kJ mol -1 to 70.0 kJ mol -1 after MgH 2 was co-doped with 10 wt% K 2 NiF 6 and 5 wt% CNTs. Based on the experimental results, the hydrogen storage properties of the MgH 2 /K 2 NiF 6 /CNTs composite is enhanced because of the catalytic effects of the active species of KF, KH and Mg 2 Ni that are formed in situ during dehydrogenation, as well as the unique structure of CNTs.

The Dynamics of Heat A Unified Approach to Thermodynamics and Heat Transfer

CERN Document Server

Fuchs, Hans U

2010-01-01

Based on courses for students of science, engineering, and systems science at the Zurich University of Applied Sciences at Winterthur, this text approaches the fundamentals of thermodynamics from the point of view of continuum physics. By describing physical processes in terms of the flow and balance of physical quantities, the author achieves a unified approach to hydraulics, electricity, mechanics and thermodynamics. In this way, it becomes clear that entropy is the fundamental property that is transported in thermal processes (i.e., heat), and that temperature is the corresponding potential. The resulting theory of the creation, flow, and balance of entropy provides the foundation of a dynamical theory of heat. This extensively revised and updated second edition includes new material on dynamical chemical processes, thermoelectricity, and explicit dynamical modeling of thermal and chemical processes. To make the book more useful for courses on thermodynamics and physical chemistry at different levels, cove...

The Power of Cooperation in International Paleoclimate Science: Examples from the PAGES 2k Network and the Ocean2k Working Group

Science.gov (United States)

Addison, J. A.

2015-12-01

The Past Global Changes (PAGES) project of IGBP and Future Earth supports research to understand the Earth's past environment to improve future climate predictions and inform strategies for sustainability. Within this framework, the PAGES 2k Network was established to provide a focus on the past 2000 years, a period that encompasses Medieval Climate Anomaly warming, Little Ice Age cooling, and recent anthropogenically-forced climate change. The results of these studies are used for testing earth system models, and for understanding decadal- to centennial-scale variability, which is needed for long-term planning. International coordination and cooperation among the nine regional Working Groups that make up the 2k Network has been critical to the success of PAGES 2k. The collaborative approach is moving toward scientific achievements across the regional groups, including: (i) the development of a community-driven open-access proxy climate database; (ii) integration of multi-resolution proxy records; (iii) development of multivariate climate reconstructions; and (iv) a leap forward in the spatial resolution of paleoclimate reconstructions. The last addition to the 2k Network, the Ocean2k Working Group has further innovated the collaborative approach by: (1) creating an open, receptive environment to discuss ideas exclusively in the virtual space; (2) employing an array of real-time collaborative software tools to enable communication, group document writing, and data analysis; (3) consolidating executive leadership teams to oversee project development and manage grassroots-style volunteer pools; and (4) embracing the value-added role that international and interdisciplinary science can play in advancing paleoclimate hypotheses critical to understanding future change. Ongoing efforts for the PAGES 2k Network are focused on developing new standards for data quality control and archiving. These tasks will provide the foundation for new and continuing "trans-regional" 2k

The short-circuit test results of 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer with fault current limiting function

International Nuclear Information System (INIS)

Tomioka, A.; Bohno, T.; Kakami, S.; Isozaki, M.; Watanabe, K.; Toyama, K.; Sugiyama, S.; Konno, M.; Gosho, Y.; Okamoto, H.; Hayashi, H.; Tsutsumi, T.; Iwakuma, M.; Saito, T.; Tanabe, K.; Shiohara, Y.

2013-01-01

Highlights: ► We manufactured the 400 kV A-class YBCO model transformer with FCL function. ► Short-circuit test was performed by applying 6.9 kV on primary side. ► The short-circuit current was limited to 174 A for a prospective current of 559 A. ► It agreed with the design and we also confirmed the I c did not degrade. ► The results suggest the possibility to design YBCO transformers with FCL function. -- Abstract: We are developing an elemental technology for 66/6.9 kV 20 MVA-class superconducting power transformer with fault current limiting function. In order to obtain the characteristics of YBCO conductor when the AC over current supplied to the conductor, the model coils were manufactured with YBCO tapes and tested. Based on these results, we manufactured the 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer with fault current limiting function and performed short-circuit test. At the 0.25 s after short-circuit, the short-circuit current of primary winding was limited to about 174 A for a prospective current of 559 A. It was consistent with the design. The I–V characteristics of the winding did not change before and after the test. We consider the model transformer to be able to withstand AC over-current with the function of current limiting. The results suggest the possibility to design YBCO superconducting transformers with fault current limiting function for practical power grid

K4 Fe(CN)6 as a spectrophotometric agent for uranium analysis

International Nuclear Information System (INIS)

Soedyartomo; Tarwita.

1976-01-01

The properties of K 4 Fe(CN) 6 as a spectrophotometric agent for Uranium analysis was observed by putting some experiment into practice. The experiment covers the observation of expanding colour stability, the optimization of operating condition (p,H. and wavelength), the effect of K 4 Fe(CN) 6 concentration and the preparation of its standard curves (transmitansion vs uranium concentration) and the observation of the interfering metal spectra s (Cu ++ , Fe ++ ) either of its mixtures or themselves alone, has been carried out. The result and discussion on it are given. (author)

On unified-entropy characterization of quantum channels

International Nuclear Information System (INIS)

Rastegin, A E

2012-01-01

We consider properties of quantum channels with the use of unified entropies. Extremal unravelings of quantum channel with respect to these entropies are examined. The concept of map entropy is extended in terms of the unified entropies. The map (q, s)-entropy is naturally defined as the unified (q, s)-entropy of a rescaled dynamical matrix of given quantum channel. Inequalities of Fannes type are obtained for introduced entropies in terms of both the trace and Frobenius norms of difference between corresponding dynamical matrices. Additivity properties of introduced map entropies are discussed. The known inequality of Lindblad with the entropy exchange is generalized to many of the unified entropies. For the tensor product of a pair of quantum channels, we derive a two-sided estimate on the output entropy of a maximally entangled input state. (paper)

Support Vector Data Descriptions and k-Means Clustering: One Class?

Science.gov (United States)

Gornitz, Nico; Lima, Luiz Alberto; Muller, Klaus-Robert; Kloft, Marius; Nakajima, Shinichi

2017-09-27

We present ClusterSVDD, a methodology that unifies support vector data descriptions (SVDDs) and k-means clustering into a single formulation. This allows both methods to benefit from one another, i.e., by adding flexibility using multiple spheres for SVDDs and increasing anomaly resistance and flexibility through kernels to k-means. In particular, our approach leads to a new interpretation of k-means as a regularized mode seeking algorithm. The unifying formulation further allows for deriving new algorithms by transferring knowledge from one-class learning settings to clustering settings and vice versa. As a showcase, we derive a clustering method for structured data based on a one-class learning scenario. Additionally, our formulation can be solved via a particularly simple optimization scheme. We evaluate our approach empirically to highlight some of the proposed benefits on artificially generated data, as well as on real-world problems, and provide a Python software package comprising various implementations of primal and dual SVDD as well as our proposed ClusterSVDD.

K Gowthamarajan

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K Gowthamarajan. Articles written in Resonance – Journal of Science Education. Volume 8 Issue 5 May 2003 pp 38-46 General Article. Oral Insulin – Fact or Fiction? - Possibilities of Achieving Oral Delivery of Insulin · K Gowthamarajan Giriraj T Kulkarni.

Technology Integration in K-12 Science Classrooms: An Analysis of Barriers and Implications

Science.gov (United States)

Hechter, Richard P.; Vermette, Laurie Anne

2013-01-01

This paper examines the barriers to technology integration for Manitoban K-12 inservice science educators (n = 430) based on a 10-item online survey; results are analyzed according to teaching stream using the Technology, Pedagogy, and Content Knowledge (TPACK) framework. Quantitative descriptive statistics indicated that the leading barriers…

Stabilization of the H,K-ATPase M5M6 membrane hairpin by K+ ions. Mechanistic significance for p2-type atpases.

Science.gov (United States)

Gatto, C; Lutsenko, S; Shin, J M; Sachs, G; Kaplan, J H

1999-05-14

The integral membrane protein, the gastric H,K-ATPase, is an alpha-beta heterodimer, with 10 putative transmembrane segments in the alpha-subunit and one such segment in the beta-subunit. All transmembrane segments remain within the membrane domain following trypsinization of the intact gastric H,K-ATPase in the presence of K+ ions, identified as M1M2, M3M4, M5M6, and M7, M8, M9, and M10. Removal of K+ ions from this digested preparation results in the selective loss of the M5M6 hairpin from the membrane. The release of the M5M6 fragment is directed to the extracellular phase as evidenced by the accumulation of the released M5M6 hairpin inside the sealed inside out vesicles. The stabilization of the M5M6 hairpin in the membrane phase by the transported cation as well as loss to the aqueous phase in the absence of the transported cation has been previously observed for another P2-type ATPase, the Na, K-ATPase (Lutsenko, S., Anderko, R., and Kaplan, J. H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7936-7940). Thus, the effects of the counter-transported cation on retention of the M5M6 segment in the membrane as compared with the other membrane pairs may be a general feature of P2-ATPase ion pumps, reflecting a flexibility of this region that relates to the mechanism of transport.

Determination of stability constants of K and Cs nitrate complex with dicyclohexyl-18-crown-6 and dibenzo-18-crown-6 in isopropanol aqueous solutions

International Nuclear Information System (INIS)

Myasoedova, T.G.; Ponomareva, A.V.; Zagorets, P.A.; Filippov, E.A.

1984-01-01

Total stability constants of K and Cs nitrate complexes with dicyclohexyl-18-crown-6 and dibenzo-18-crown-6 in isopropanol aqueous solutions were determined by the method of low-frequency contact conductometry. Clearly defined K/Cs selectivity is observed for the system with dibenzo-18-crown-6. It is shown that lgβ depends on permittivity of the solvent. The decrease of permittivity of isopropanol aqueous solutions results in reduction of K/Cs selectivity of DB18C6

Determination of stability constants of K and Cs nitrate complex with dicyclohexyl-18-crown-6 and dibenzo-18-crown-6 in isopropanol aqueous solutions

Energy Technology Data Exchange (ETDEWEB)

Myasoedova, T G; Ponomareva, A V; Zagorets, P A; Filippov, E A [Moskovskij Khimiko-Tekhnologicheskij Inst. (USSR)

1984-08-01

Total stability constants of K and Cs nitrate complexes with dicyclohexyl-18-crown-6 and dibenzo-18-crown-6 in isopropanol aqueous solutions were determined by the method of low-frequency contact conductometry. Clearly defined K/Cs selectivity is observed for the system with dibenzo-18-crown-6. It is shown that lg..beta.. depends on permittivity of the solvent. The decrease of permittivity of isopropanol aqueous solutions results in reduction of K/Cs selectivity of DB18C6.

V K Agrawal

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. V K Agrawal. Articles written in Bulletin of Materials Science. Volume 33 Issue 4 August 2010 pp 383-390 Electrical Properties. Temperature dependence of electromechanical properties of PLZT /57/43 ceramics · A K Shukla V K Agrawal I M L Das Janardan Singh S L ...

K-XANES study of YBa2Cu3O6.96 system

International Nuclear Information System (INIS)

Mishra, A.; Varshney, D.; Shivkumar, K.M.; Pandey, D.

1998-01-01

The copper K-edge x-ray absorption near edge structure (XANES) has been recorded in both CuO and YBaCuO samples on Cauchois type spectrograph with 0.4 m radius of curvature and a laboratory source of x-rays. The sample of YBa 2 Cu 3 ) 6.96 (T c =91K) were prepared by solid state route. The Cu K-XANES measurements were made on the powdered sample. The x-ray parameters, e.g., K-edge shift (ΔE k ), shift of principal absorption maximum (δE K ) and edge-width (δE A ) with reference to metal K-edge have been reported. The value of edge-shift of YBaCuO is larger than parent CuO. Also the smaller value of edge-width in YBaCuO is indicative of its ionic character. (author)

Exploring Sun-Earth Connections: A Physical Science Program for (K-8)Teachers

Science.gov (United States)

Michels, D. J.; Pickert, S. M.; Thompson, J. L.; Montrose, C. J.

2003-12-01

An experimental, inquiry-based physical science curriculum for undergraduate, pre-service K-8 teachers is under development at the Catholic University of America in collaboration with the Solar Physics Branch of the Naval Research Laboratory and NASA's Sun-Earth Connection missions. This is a progress report. The current, stunningly successful exploratory phase in Sun-Earth Connection (SEC) physics, sparked by SOHO, Yohkoh, TRACE, and other International Solar Terrestrial Physics (ISTP) and Living With a Star (LWS) programs, has provided dynamic, visually intuitive data that can be used for teaching basic physical concepts such as the properties of gravitational and electromagnetic fields which are manifest in beautiful imagery of the astrophysical plasmas of the solar atmosphere and Earth's auroras. Through a team approach capitalizing on the combined expertise of the Catholic University's departments of Education and Physics and of NRL solar researchers deeply involved in SEC missions we have laid out a program that will teach non-science-major undergraduates a very limited number of physical science concepts but in such a way as to develop for each one both a formal understanding and an intuitive grasp that will instill confidence, spark interest and scientific curiosity and, ideally, inspire a habit of lifetime inquiry and professional growth. A three-semester sequence is planned. The first semester will be required of incoming Education freshmen. The second and third semesters will be of such a level as to satisfy the one-year science requirement for non-science majors in the College of Arts and Sciences. The approach as adopted will integrate physics content and educational methods, with each concept introduced through inquiry-based, hands-on investigation using methods and materials directly applicable to K-8 teaching situations (Exploration Phase). The topic is further developed through discussion, demonstration and lecture, introducing such mathematical

Model of unified gauge fields

International Nuclear Information System (INIS)

Leite Lopes, J.

1998-04-01

In this work, we discuss the physical ideas which represents the basis for the unified gauge field model. Despite of the difficulties that we presently have for embodying in a natural manner muons and hadrons in that model, we have the feeling that we are on the way which seems to lead to the construction of a theory in which the Maxwell electromagnetic field and the Fermi weak interaction field are manifestations of a unique subjacent physical entity - the unified gauge fields. (author)

B K Godwal

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B K Godwal. Articles written in Bulletin of Materials Science. Volume 23 Issue 2 April 2000 pp 151-154 Instrumentation. A CCD area detector for X-ray diffraction under high pressure for rotating anode source · Amar Sinha Alka B Garg V Vijayakumar B K Godwal S K Sikka.

Unified gauge theories with spontaneous symmetry breaking

International Nuclear Information System (INIS)

MacDowell, S.W.

1975-01-01

Unified gauge theories with spontaneous symmetry breaking are studied with a view to renormalize quantum field theory. Georgi-Glashow and Weinberg-Salam models to unify weak and electromagnetic interactions are discussed in detail. Gauge theories of strong interactions are also considered [pt

Science education as a pathway to teaching language literacy: a critical book review

Science.gov (United States)

Tolbert, Sara

2011-03-01

In this paper, I present a critical review of the recent book, Science Education as a Pathway to Teaching Language Literacy, edited by Alberto J. Rodriguez. This volume is a timely collection of essays in which the authors bring to attention both the successes and challenges of integrating science instruction with literacy instruction (and vice versa). Although several themes in the book merit further attention, a central unifying issue throughout all of the chapters is the task of designing instruction which (1) gives students access to the dominant Discourses in science and literacy, (2) builds on students' lived experiences, and (3) connects new material to socially and culturally relevant contexts in both science and literacy instruction— all within the high stakes testing realities of teachers and students in public schools. In this review, I illustrate how the authors of these essays effectively address this formidable challenge through research that `ascends to the concrete'. I also discuss where we could build on the work of the authors to integrate literacy and science instruction with the purpose of `humanizing and democratizing' science education in K-12 classrooms.

Chemical shift of Mn and Cr K-edges in X-ray absorption

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 36; Issue 6. Chemical shift of Mn and Cr K-edges in X-ray absorption spectroscopy with synchrotron radiation. D Joseph A K Yadav S N Jha D Bhattacharyya. Volume 36 Issue 6 November 2013 pp ...

15 CFR 950.6 - Environmental Science Information Center (ESIC).

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Environmental Science Information Center (ESIC). 950.6 Section 950.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE...

K Srinivasan

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K Srinivasan. Articles written in Bulletin of Materials Science. Volume 23 Issue 1 February 2000 pp 35-37 Metallic Materials. Impact toughness of ternary Al–Zn–Mg alloys in as cast and homogenized condition measured in the temperature range 263–673 K · Harish Kundar ...

UUI: Reusable Spatial Data Services in Unified User Interface at NASA GES DISC

Science.gov (United States)

Petrenko, M.; Hegde, M.; Bryant, K.; Pham, L.

2016-12-01

Unified User Interface (UUI) is a next-generation operational data access tool that has been developed at Goddard Earth Sciences Data and Information Services Center (GES DISC) to provide a simple, unified, and intuitive one-stop shop experience for the key data services available at GES DISC, including subsetting (Simple Subset Wizard - SSW), granule file search (Mirador), plotting (Giovanni), and other legacy spatial data services. UUI has been built based on a flexible infrastructure of reusable web services - self-contained building blocks that can easily be plugged into spatial applications, including third-party clients or services, to easily enable new functionality as new datasets and services become available. In this presentation, we will discuss our experience in designing UUI services based on open industry standards. We will also explain how the resulting framework can be used for a rapid development, deployment, and integration of spatial data services, facilitating efficient access and dissemination of spatial data sets.

UUI: Reusable Spatial Data Services in Unified User Interface at NASA GES DISC

Science.gov (United States)

Petrenko, Maksym; Hegde, Mahabaleshwa; Bryant, Keith; Pham, Long B.

2016-01-01

Unified User Interface (UUI) is a next-generation operational data access tool that has been developed at Goddard Earth Sciences Data and Information Services Center(GES DISC) to provide a simple, unified, and intuitive one-stop shop experience for the key data services available at GES DISC, including subsetting (Simple Subset Wizard -SSW), granule file search (Mirador), plotting (Giovanni), and other legacy spatial data services. UUI has been built based on a flexible infrastructure of reusable web services self-contained building blocks that can easily be plugged into spatial applications, including third-party clients or services, to easily enable new functionality as new datasets and services become available. In this presentation, we will discuss our experience in designing UUI services based on open industry standards. We will also explain how the resulting framework can be used for a rapid development, deployment, and integration of spatial data services, facilitating efficient access and dissemination of spatial data sets.

Low-energy neutral current phenomenology and grand unified theories

International Nuclear Information System (INIS)

Del Aguila, F.; Mendez, A.

1981-01-01

We derive necessary and sufficient conditions to be satisfied by any expanded electroweak gauge model in order to reproduce the standard model low-energy neutral current predictions. These conditions imply several constraints on the neutral gauge boson masses and the quantum number assignments for the ordinary fermions. Using these conditions, we prove that the popular grand unified theories based on the gauge groups SO(10) and E6 can only accommodate trivial extensions of the standard model. As a consequence, if any of these grand unified models works at some energy scale, present low-energy neutral current phenomenology implies that the Z-boson must be produced with the expected mass and couplings to the ordinary fermions. Any additional neutral gauge boson (with the possible exception of very heavy ones) could only be produced in hadronic collisions and it would not decay in e + e - . (orig.)

K2-141 b A 5-M-circle plus super-Earth transiting a K7V star every 6.7 h

DEFF Research Database (Denmark)

Barragan, O.; Gandolfi, D.; Dai, F.

2018-01-01

We report on the discovery of K2-141 b (EPIC 246393474 b), an ultra-short-period super-Earth on a 6.7 h orbit transiting an active K7V star based on data from K2 campaign 12. We confirmed the planet's existence and measured its mass with a series of follow-up observations: seeing-limited MuSCAT i...

Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin.

Science.gov (United States)

Jung, Minyoung; Lee, Sanghoon; Park, Hwa-young; Youm, Jong-Kyung; Jeong, Sekyoo; Bae, Jonghwan; Kwon, Mi Jung; Park, Byeong Deog; Lee, Seung Hun; Choi, Eung Ho

2011-04-01

Recently, we reported on the anti-ageing effects of K6PC-5. This compound induced keratinocyte differentiation and fibroblast proliferation by increasing sphingosine-1 phosphate synthesis. We performed this study to confirm the anti-ageing effects of new synthetic products (the K6EAA series) derived from K6PC-5 through an amino group induction. Cellular responses such as differentiation, proliferation and calcium mobilization were investigated using cultured human keratinocytes and fibroblasts. Also, we measured the expressions of collagen mRNA and protein using real time RT-PCR and ELISA, respectively. The K6EAA-L12 product, selected by in vitro screening, was evaluated for anti-ageing effects on intrinsically and extrinsically (photo) aged models of hairless mice. In the intrinsically aged murine skin, K6EAA-L12 showed anti-ageing effects by activating collagen synthesis, eventually causing dermal thickening. Also, in the photo-aged skin, the dermal collagen density and dermal thickness were increased. In photo-aged murine skin, K6EAA-L12 increased stratum corneum integrity by increasing corneodesmosome density and improved the barrier recovery rate. However, there were no changes in the expressions of epidermal differentiation maker proteins. In conclusion, topical K6EAA-L12, a new synthetic K6PC-5 derivative, improves intrinsically and extrinsically (photo) aged skin by increasing the collagen density and improving the skin barrier function. © 2011 John Wiley & Sons A/S.

Finite unified models

Energy Technology Data Exchange (ETDEWEB)

Kapetanakis, D. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Mondragon, M. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Zoupanos, G. (National Technical Univ., Athens (Greece). Physics Dept.)

1993-09-01

We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

Finite unified models

International Nuclear Information System (INIS)

Kapetanakis, D.; Mondragon, M.; Zoupanos, G.

1993-01-01

We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

Unifying inflation with late-time acceleration by a BIonic system

Energy Technology Data Exchange (ETDEWEB)

Sepehri, Alireza, E-mail: alireza.sepehri@uk.ac.ir [Faculty of Physics, Shahid Bahonar University, P.O. Box 76175, Kerman (Iran, Islamic Republic of); Rahaman, Farook, E-mail: rahaman@iucaa.ernet.in [Department of Mathematics, Jadavpur University, Kolkata 700032, West Bengal (India); Setare, Mohammad Reza, E-mail: rezakord@ipm.ir [Department of Science, Campus of Bijar, University of Kurdistan, Bijar (Iran, Islamic Republic of); Pradhan, Anirudh, E-mail: pradhan@iucaa.ernet.in [Department of Mathematics, Institute of Applied Sciences & Humanities, GLA University, Mathura-281 406, U.P. (India); Capozziello, Salvatore, E-mail: capozziello@na.infn.it [Dipartimento di Fisica, Universitá di Napoli “Federico II”, I-80126 Napoli (Italy); INFN Sezione di Napoli, Complesso Universitario di Monte S. Angelo, Edificio G, I-80126 Napoli (Italy); Gran Sasso Science Institute (INFN), Viale F. Crispi, 7, I-67100 L' Aquila (Italy); Sardar, Iftikar Hossain, E-mail: iftikar.spm@gmail.com [Department of Mathematics, Jadavpur University, Kolkata 700032, West Bengal (India)

2015-07-30

We propose a cosmological model that unifies inflation, deceleration and acceleration phases of expansion history by a BIonic system. At the beginning, there are k black fundamental strings that transited to the BIon configuration at a given corresponding point. Here, two coupled universes, brane and antibrane, are created interacting each other through a wormhole and inflate. With decreasing temperature, the energy of this wormhole flows into the universe branes and leads to inflation. After a short time, the wormhole evaporates, the inflation ends and a deceleration epoch starts. By approaching the brane and antibrane universes together, a tachyon is born, grows and causes the creation of a new wormhole. At this time, the brane and antibrane universes result connected again and the late-time acceleration era of the universe begins. We compare our model with previous unified phantom models and observational data obtaining some cosmological parameters like temperature in terms of time. We also find that deceleration parameter is negative during inflation and late-time acceleration epochs, while it is positive during the deceleration era. This means that the model is consistent, in principle, with cosmological observations.

Unifying inflation with late-time acceleration by a BIonic system

Directory of Open Access Journals (Sweden)

Alireza Sepehri

2015-07-01

Full Text Available We propose a cosmological model that unifies inflation, deceleration and acceleration phases of expansion history by a BIonic system. At the beginning, there are k black fundamental strings that transited to the BIon configuration at a given corresponding point. Here, two coupled universes, brane and antibrane, are created interacting each other through a wormhole and inflate. With decreasing temperature, the energy of this wormhole flows into the universe branes and leads to inflation. After a short time, the wormhole evaporates, the inflation ends and a deceleration epoch starts. By approaching the brane and antibrane universes together, a tachyon is born, grows and causes the creation of a new wormhole. At this time, the brane and antibrane universes result connected again and the late-time acceleration era of the universe begins. We compare our model with previous unified phantom models and observational data obtaining some cosmological parameters like temperature in terms of time. We also find that deceleration parameter is negative during inflation and late-time acceleration epochs, while it is positive during the deceleration era. This means that the model is consistent, in principle, with cosmological observations.

Unifying inflation with late-time acceleration by a BIonic system

International Nuclear Information System (INIS)

Sepehri, Alireza; Rahaman, Farook; Setare, Mohammad Reza; Pradhan, Anirudh; Capozziello, Salvatore; Sardar, Iftikar Hossain

2015-01-01

We propose a cosmological model that unifies inflation, deceleration and acceleration phases of expansion history by a BIonic system. At the beginning, there are k black fundamental strings that transited to the BIon configuration at a given corresponding point. Here, two coupled universes, brane and antibrane, are created interacting each other through a wormhole and inflate. With decreasing temperature, the energy of this wormhole flows into the universe branes and leads to inflation. After a short time, the wormhole evaporates, the inflation ends and a deceleration epoch starts. By approaching the brane and antibrane universes together, a tachyon is born, grows and causes the creation of a new wormhole. At this time, the brane and antibrane universes result connected again and the late-time acceleration era of the universe begins. We compare our model with previous unified phantom models and observational data obtaining some cosmological parameters like temperature in terms of time. We also find that deceleration parameter is negative during inflation and late-time acceleration epochs, while it is positive during the deceleration era. This means that the model is consistent, in principle, with cosmological observations

A unified approach to model uptake kinetics of trace elements in complex aqueous – solid solution systems

International Nuclear Information System (INIS)

Thien, Bruno M.J.; Kulik, Dmitrii A.; Curti, Enzo

2014-01-01

Highlights: • There are several models able to describe trace element partitioning in growing minerals. • To describe complex systems, those models must be embedded in a geochemical code. • We merged two models into a unified one suitable for implementation in a geochemical code. • This unified model was tested against coprecipitation experimental data. • We explored how our model reacts to solution depletion effects. - Abstract: Thermodynamics alone is usually not sufficient to predict growth-rate dependencies of trace element partitioning into host mineral solid solutions. In this contribution, two uptake kinetic models were analyzed that are promising in terms of mechanistic understanding and potential for implementation in geochemical modelling codes. The growth Surface Entrapment Model (Watson, 2004) and the Surface Reaction Kinetic Model (DePaolo, 2011) were shown to be complementary, and under certain assumptions merged into a single analytical expression. This Unified Uptake Kinetics Model was implemented in GEMS3K and GEM-Selektor codes ( (http://gems.web.psi.ch)), a Gibbs energy minimization package for geochemical modelling. This implementation extends the applicability of the unified uptake kinetics model to accounting for non-trivial factors influencing the trace element partitioning into solid solutions, such as the changes in aqueous solution composition and speciation, or the depletion effects in closed geochemical systems

Development and Implementation of an inquiry lesson for grades 6-12 explicitly teaching the Nature and Process of Science, from ship to shore, for core data of the Cretaceous-Paleogene (K-Pg)

Science.gov (United States)

Cohen, E.; Quan, T. M.

2012-12-01

The mass extinction event at the Cretaceous-Paleogene (K-Pg) boundary was the result of a bolide impact, and is popularly known for the extinction of the dinosaurs, but is also one of the largest Paleogene mass extinctions identified. In addition, it was followed by a period of drastic changes in ecological conditions, including a complete alteration of the global carbon cycle; the root cause of this change is still debated. Little information is known regarding changes in the nitrogen cycle during these periods of mass extinction and recovery. Given the importance of the nitrogen cycle to primary production and its relationship to the redox state of the local environment, determining changes in the nitrogen cycle will provide important information as to the processes of global mass extinction and the subsequent recovery. Three lessons for students' grade 6-12 were created to support the content surrounding: National Science Education Content Standards: Standard A: Science as Inquiry Standard D: Earth and Space Science Ocean Literacy Essential Principles: 3. The ocean is a major influence on weather and climate 7. The ocean is largely unexplored In the Nature of Science activity, students sequence a series of photographs to illustrate the scientific process of one scientist, Dr. Tracy Quan, of Oklahoma State University as she uses deep sea core data obtained by the JOIDES Resolution research vessel to investigate the climate during the mass extinction that took place ~ 65 million years ago. By reading the information contained on each card and studying the pictures, students learn that science is a dynamic, non-linear, and creative process. Students do not have to create the exact order Dr. Quan uses as her scientific process, but they need to justify their reasoning for placing the pictures in the order they did. The activity begins with a photo of the JOIDES Resolution and ends during a presentation at a scientific conference. There are 21 other photo cards

Seagrass from Unified Florida Reef Tract Map (NODC Accession 0123059)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Seagrass areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified Reef Map) provides...

Mi-STAR Unit Challenges serve as a model for integrating earth science and systems thinking in a Next Generation Science Standards (NGSS) aligned curriculum.

Science.gov (United States)

Gochis, E. E.; Tubman, S.; Matthys, T.; Bluth, G.; Oppliger, D.; Danhoff, B.; Huntoon, J. E.

2017-12-01

Michigan Science Teaching and Assessment Reform (Mi-STAR) is developing an NGSS-aligned middle school curriculum and associated teacher professional learning program in which science is taught and learned as an integrated body of knowledge that can be applied to address societal issues. With the generous support of the Herbert H. and Grace A. Dow Foundation, Mi-STAR has released several pilot-tested units through the Mi-STAR curriculum portal at mi-star.mtu.edu. Each of these units focuses on an ongoing `Unit Challenge' investigation that integrates STEM content across disciplinary boundaries, stimulates interest, and engages students in using scientific practices to address 21st century challenges. Each Mi-STAR unit is connected to a Unifying NGSS Crosscutting Concept (CCC) that allows students to recognize the concepts that are related to the phenomena or problems under investigation. In the 6th grade, students begin with an exploration of the CCC Systems and System Models. Through repeated applications across units, students refine their understanding of what a system is and how to model a complex Earth system. An example 6th grade unit entitled "Water on the Move: The Water Cycle," provides an example of how Mi-STAR approaches the use of Unifying CCCs and Unit Challenges to enhance middle school students' understanding of the interconnections of Earth system processes and human activities. Throughout the unit, students use a series of hands-on explorations and simulations to explore the hydrologic cycle and how human activity can alter Earth systems. Students develop new knowledge through repeated interactions with the Unit Challenge, which requires development of system models and construction of evidence-based arguments related to flooding problems in a local community. Students have the opportunity to make predictions about how proposed land-use management practices (e.g. development of a skate-park, rain garden, soccer field, etc.) can alter the earth

C M K Nair

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. C M K Nair. Articles written in Bulletin of Materials Science. Volume 24 Issue 2 April 2001 pp 249-252 Crystal Growth. Thermal behaviour of strontium tartrate single crystals grown in gel · M H Rahimkutty K Rajendra Babu K Sreedharan Pillai M R Sudarsana Kumar C M K Nair.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 129; Issue 6. The impact of sugar and fatty acid on the bioactivity of N-fatty acyl-L-tyrosine aglycone. SRIKANTH VUDHGIRI R B N PRASAD Y POORNACHANDRA C GANESH KUMAR E ANJANEYULU K SIRISHA RAM CHANDRA REDDY JALA. Regular Aricle ...

A unified universe

DEFF Research Database (Denmark)

Codello, Alessandro; Jain, Rajeev Kumar

2018-01-01

We present a unified evolution of the universe from very early times until the present epoch by including both the leading local correction R2 and the leading non-local term R1□2R to the classical gravitational action. We find that the inflationary phase driven by R2 term gracefully exits...... in a transitory regime characterized by coherent oscillations of the Hubble parameter. The universe then naturally enters into a radiation dominated epoch followed by a matter dominated era. At sufficiently late times after radiation–matter equality, the non-local term starts to dominate inducing an accelerated...... expansion of the universe at the present epoch. We further exhibit the fact that both the leading local and non-local terms can be obtained within the covariant effective field theory of gravity. This scenario thus provides a unified picture of inflation and dark energy in a single framework by means...

The Simplest Unified Growth Theory

DEFF Research Database (Denmark)

Strulik, Holger; Weisdorf, Jacob Louis

This paper provides a unified growth theory, i.e. a model that explains the very long-run economic and demographic development path of industrialized economies, stretching from the pre-industrial era to present-day and beyond. Making strict use of Malthus' (1798) so-called preventive check...... hypothesis - that fertility rates vary inversely with the price of food - the current study offers a new and straightforward explanation for the demographic transition and the break with the Malthusian era. The current framework lends support to existing unified growth theories and is well in tune...

Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

Directory of Open Access Journals (Sweden)

Qingzhang Zhu

2017-01-01

Full Text Available Objective: IP6 kinases (IP6Ks regulate cell metabolism and survival. Mice with global (IP6K1-KO or adipocyte-specific (AdKO deletion of IP6K1 are protected from diet induced obesity (DIO at ambient (23 °C temperature. AdKO mice are lean primarily due to increased AMPK mediated thermogenic energy expenditure (EE. Thus, at thermoneutral (30 °C temperature, high fat diet (HFD-fed AdKO mice expend energy and gain body weight, similar to control mice. IP6K1 is ubiquitously expressed; thus, it is critical to determine to what extent the lean phenotype of global IP6K1-KO mice depends on environmental temperature. Furthermore, it is not known whether IP6K1 regulates AMPK mediated EE in cells, which do not express UCP1. Methods: Q-NMR, GTT, food intake, EE, QRT-PCR, histology, mitochondrial oxygen consumption rate (OCR, fatty acid metabolism assays, and immunoblot studies were conducted in IP6K1-KO and WT mice or cells. Results: Global IP6K1 deletion mediated enhancement in EE is impaired albeit not abolished at 30 °C. As a result, IP6K1-KO mice are protected from DIO, insulin resistance, and fatty liver even at 30 °C. Like AdKO, IP6K1-KO mice display enhanced adipose tissue browning. However, unlike AdKO mice, thermoneutrality only partly abolishes browning in IP6K1-KO mice. Cold (5 °C exposure enhances carbohydrate expenditure, whereas 23 °C and 30 °C promote fat oxidation in HFD-KO mice. Furthermore, IP6K1 deletion diminishes cellular fat accumulation via activation of the AMPK signaling pathway. Conclusions: Global deletion of IP6K1 ameliorates obesity and insulin resistance irrespective of the environmental temperature conditions, which strengthens its validity as an anti-obesity target. Keywords: IP6K, Obesity, Diabetes, Energy expenditure, β-oxidation

D-Glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K

International Nuclear Information System (INIS)

Oh, Hyun-Ji; Lee, Jason S.; Song, Dae-Kyu; Shin, Dong-Hoon; Jang, Byeong-Churl; Suh, Seong-Il; Park, Jong-Wook; Suh, Min-Ho; Baek, Won-Ki

2007-01-01

Although D-glucosamine has been reported as an inhibitor of tumor growth both in vivo and in vitro, the mechanism for the anticancer effect of D-glucosamine is still unclear. Since there are several reports suggesting D-glucosamine inhibits protein synthesis, we examined whether D-glucosamine affects p70S6 K activity, an important signaling molecule involved in protein translation. In the present study, we found D-glucosamine inhibited the activity of p70S6K and the proliferation of DU145 prostate cancer cells and MDA-MB-231 breast cancer cells. D-Glucosamine decreased phosphorylation of p70S6K, and its downstream substrates RPS6, and eIF-4B, but not mTOR and 4EBP1 in DU145 cells, suggesting that D-glucosamine induced inhibition of p70S6K is not through the inhibition of mTOR. In addition, D-glucosamine enhanced the growth inhibitory effects of rapamycin, a specific inhibitor of mTOR. These findings suggest that D-glucosamine can inhibit growth of cancer cells through dephosphorylation of p70S6K

Quality Assessment of Collection 6 MODIS Atmospheric Science Products

Science.gov (United States)

Manoharan, V. S.; Ridgway, B.; Platnick, S. E.; Devadiga, S.; Mauoka, E.

2015-12-01

Since the launch of the NASA Terra and Aqua satellites in December 1999 and May 2002, respectively, atmosphere and land data acquired by the MODIS (Moderate Resolution Imaging Spectroradiometer) sensor on-board these satellites have been reprocessed five times at the MODAPS (MODIS Adaptive Processing System) located at NASA GSFC. The global land and atmosphere products use science algorithms developed by the NASA MODIS science team investigators. MODAPS completed Collection 6 reprocessing of MODIS Atmosphere science data products in April 2015 and is currently generating the Collection 6 products using the latest version of the science algorithms. This reprocessing has generated one of the longest time series of consistent data records for understanding cloud, aerosol, and other constituents in the earth's atmosphere. It is important to carefully evaluate and assess the quality of this data and remove any artifacts to maintain a useful climate data record. Quality Assessment (QA) is an integral part of the processing chain at MODAPS. This presentation will describe the QA approaches and tools adopted by the MODIS Land/Atmosphere Operational Product Evaluation (LDOPE) team to assess the quality of MODIS operational Atmospheric products produced at MODAPS. Some of the tools include global high resolution images, time series analysis and statistical QA metrics. The new high resolution global browse images with pan and zoom have provided the ability to perform QA of products in real time through synoptic QA on the web. This global browse generation has been useful in identifying production error, data loss, and data quality issues from calibration error, geolocation error and algorithm performance. A time series analysis for various science datasets in the Level-3 monthly product was recently developed for assessing any long term drifts in the data arising from instrument errors or other artifacts. This presentation will describe and discuss some test cases from the

Towards 6Li-40K ground state molecules

International Nuclear Information System (INIS)

Brachmann, Johannes Felix Simon

2013-01-01

The production of a quantum gas with strong long - range dipolar interactions is a major scientific goal in the research field of ultracold gases. In their ro - vibrational ground state Li-K dimers possess a large permanent dipole moment, which could possibly be exploited for the realization of such a quantum gas. A production of these molecules can be achieved by the association of Li and K at a Feshbach resonance, followed by a coherent state transfer. In this thesis, detailed theoretical an experimental preparations to achieve state transfer by means of Stimulated Raman Adiabatic Passage (STIRAP) are described. The theoretical preparations focus on the selection of an electronically excited molecular state that is suitable for STIRAP transfer. In this context, molecular transition dipole moments for both transitions involved in STIRAP transfer are predicted for the first time. This is achieved by the calculation of Franck-Condon factors and a determination of the state in which the 6 Li- 40 K Feshbach molecules are produced. The calculations show that state transfer by use of a single STIRAP sequence is experimentally very well feasible. Further, the optical wavelengths that are needed to address the selected states are calculated. The high accuracy of the data will allow to carry out the molecular spectroscopy in a fast and efficient manner. Further, only a comparatively narrow wavelength tuneability of the spectroscopy lasers is needed. The most suitable Feshbach resonance for the production of 6 Li- 40 K molecules at experimentally manageable magnetic field strengths is occurring at 155 G. Experimentally, this resonance is investigated by means of cross-dimensional relaxation. The application of the technique at various magnetic field strengths in the vicinity of the 155 G Feshbach resonance allows a determination of the resonance position and width with so far unreached precision. This reveals the production of molecules on the atomic side of the resonance

Project BioEYES: Accessible Student-Driven Science for K-12 Students and Teachers.

Science.gov (United States)

Shuda, Jamie R; Butler, Valerie G; Vary, Robert; Farber, Steven A

2016-11-01

BioEYES, a nonprofit outreach program using zebrafish to excite and educate K-12 students about science and how to think and act like scientists, has been integrated into hundreds of under-resourced schools since 2002. During the week-long experiments, students raise zebrafish embryos to learn principles of development and genetics. We have analyzed 19,463 participating students' pre- and post-tests within the program to examine their learning growth and attitude changes towards science. We found that at all grade levels, BioEYES effectively increased students' content knowledge and produced favorable shifts in students' attitudes about science. These outcomes were especially pronounced in younger students. Having served over 100,000 students, we find that our method for providing student-centered experiences and developing long-term partnerships with teachers is essential for the growth and sustainability of outreach and school collaborations.

K Ramesha

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K Ramesha. Articles written in Bulletin of Materials Science. Volume 34 Issue 2 April 2011 pp 271-277. Synthesis of new (Bi, La)3MSb2O11 phases (M = Cr, Mn, Fe) with KSbO3-type structure and their magnetic and photocatalytic properties · K Ramesha A S Prakash M Sathiya ...

G K Suryaprakash

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. G K Suryaprakash. Articles written in Resonance – Journal of Science Education. Volume 22 Issue 12 December 2017 pp 1111-1153 General Article. George Andrew Olah: Across Conventional Lines · Ripudaman Malhotra Thomas Mathew G K Suryaprakash.

Silicon electrodeposition from chloride-fluoride melts containing K2SiF6 and SiO2

Directory of Open Access Journals (Sweden)

Zhuk Sergey I.

2017-01-01

Full Text Available Silicon electrodeposition on glassy carbon from the KF-KCl-K2SiF6, KF-KCl-K2SiF6-KOH and KF-KCl-K2SiF6-SiO2 melts was studied by the cyclic voltammetry. Тhe electroreduction of Si(IV to metallic Si was observed as a single 4-electron wave under all considered conditions. The reactions of cathode reduction of silicon from fluoride and oxyfluoride complexes were suggested. It was shown that the process can be controlled by the preliminary transformation of SiO44- to SiF62- and SiOxFyz-. The influence of the current density on structure and morphology of silicon deposits obtained during galvanostatic electrolysis of the KF-KCl-K2SiF6-SiO2 melt was studied.

IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils.

Science.gov (United States)

Esnault, Stephane; Kelly, Elizabeth A B; Shen, Zhong-Jian; Johansson, Mats W; Malter, James S; Jarjour, Nizar N

2015-09-15

IL-5 is a major therapeutic target to reduce eosinophilia. However, all of the eosinophil-activating cytokines, such as IL-5, IL-3, and GM-CSF, are typically present in atopic diseases, including allergic asthma. As a result of the functional redundancy of these three cytokines on eosinophils and the loss of IL-5R on airway eosinophils, it is important to take IL-3 and GM-CSF into account to efficiently reduce tissue eosinophil functions. Moreover, these three cytokines signal through a common β-chain receptor but yet differentially affect protein production in eosinophils. Notably, the increased ability of IL-3 to induce the production of proteins, such as semaphorin-7A, without affecting mRNA levels suggests a unique influence of IL-3 on translation. The purpose of this study was to identify the mechanisms by which IL-3 distinctively affects eosinophil function compared with IL-5 and GM-CSF, with a focus on protein translation. Peripheral blood eosinophils were used to study intracellular signaling and protein translation in cells activated with IL-3, GM-CSF, or IL-5. We establish that, unlike GM-CSF or IL-5, IL-3 triggers prolonged signaling through activation of ribosomal protein S6 (RPS6) and the upstream kinase 90-kDa ribosomal S6 kinase (p90S6K). Blockade of p90S6K activation inhibited phosphorylation of RPS6 and IL-3-enhanced semaphorin-7A translation. Furthermore, in an allergen-challenged environment, in vivo phosphorylation of RPS6 and p90S6K was enhanced in human airway compared with circulating eosinophils. Our findings provide new insights into the mechanisms underlying differential activation of eosinophils by IL-3, GM-CSF, and IL-5. These observations identify IL-3 and its downstream intracellular signals as novel targets that should be considered to modulate eosinophil functions. Copyright © 2015 by The American Association of Immunologists, Inc.

Protonic conduction of hydrogen impurities in K2OsCl6

International Nuclear Information System (INIS)

Willemsen, H.W.; Armstrong, R.L.; Meincke, P.P.M.

1979-01-01

Dielectric measurements as a function of temperature and frequency in single crystal K 2 OsCl 6 with defects containing protons are reported. The results are consistent with a model which assumes the defect state to be a simple interstitial proton which is hydrogen bonded to the nearest neighbor chlorine ions. Temperatures greater than 180 K shows that proton diffusion is thermally activated with a mobility of 10 -2 cm 2 /V-sec whereas below this temperature it is determined by quantum tunneling between localized states

K C Manorama Thampatti

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K C Manorama Thampatti. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 3 March 1999 pp 62-70 Feature Article. Nature Watch - Rice Bowl in Turmoil: The Kuttanad Wetland Ecosystem · K C Manorama Thampatti K G Padmakumar.

Generation and characterization of polyclonal antibodies specific to N-terminal extension of p85 isoform of ribosomal protein S6 kinase 1 (p85 S6K1

Directory of Open Access Journals (Sweden)

Savinska L. O.

2015-08-01

Full Text Available Aim. Generation of polyclonal antibodies specific to the ribosomal protein S6 kinase isoform – p85S6K1 and directed to the N-terminal (1–23 aa extension of p85S6K1. Methods. Animal immunization with synthetic (1–23 aa peptide, ELISA, Western blot, Immunoprecipitation, immunofluorescent analysis. Results. Polyclonal antibodies have been generated, which specifically recognize only p85 but not p70 isoform of S6K1 in western blot, immunoprecipitation and immunofluorescence analysis. Conclusions. The obtained antibodies can be recommended for studies on the p85S6K1 and other S6K1 isoforms possessing the N-terminal extension – the identification of binding protein partners, analysis of subcellular localization under different physiological conditions, elucidation of the signal transduction pathways involving different S6K1 isoforms.

K S Mallesh

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K S Mallesh. Articles written in Resonance – Journal of Science Education. Volume 16 Issue 2 February 2011 pp 129-151 General Article. Symmetries and Conservation Laws in Classical and Quantum Mechanics - Classical Mechanics · K S Mallesh S ...

Experimental status of unified theories

International Nuclear Information System (INIS)

Bilen'kij, S.M.

1979-01-01

A standard SU(2)xU(1) theory is discussed. It is based on an assumption that the left components of fields form doublets, and the rignt ones - singlets. From the weak interaction lagrangian an expression is obtained for the effective hamiltonian describing neutrino-lepton processes. The results of discussing the experimental status of the unified theories of weak and electromagnetic interactions are in agreement with the simplest version of the unified theories - the Weinberg-Salam theory. It has been noted that the accuracy of the experiments (not exceeding 20%) is insufficient and no information is available on diagonal terms of the hamiltonian

Unified treatment of the classical and quantum mechanics

International Nuclear Information System (INIS)

Shirokov, Yu.M.

1979-01-01

Classical and Quantum Mechanics are unified in the sense that almost all axioms of both mechanics are identical. The only distinction is the explicit form of one algebraic identity. The unified theory is applied to scattering problem. (Z.M.)

ABWR (K-6/7) construction experience (computer-based safety system)

International Nuclear Information System (INIS)

Yokomura, T.

1998-01-01

TEPCO applied a digital safety system to Kashiwazaki-Kariwa Nuclear Power Station Unit Nos. 6 and 7, the world's first ABWR plant. Although this was the first time to apply a digital safety logic system in Japan, we were able to complete construction of K-6/7 very successfully and without any delay. TEPCO took a approach of developing a substantial amount of experience in digital non- safety systems before undertaking the design of the safety protection system. This paper describes the history, techniques and experience behind achieving a highly reliable digital safety system. (author)

Vivek K Gupta

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Vivek K Gupta. Articles written in Bulletin of Materials Science. Volume 28 Issue 7 December 2005 pp 725-729 Biomaterials. Supramolecular structure of S-(+)-marmesin-a linear dihydrofuranocoumarin · Sanjeev Goswami Vivek K Gupta Ashok Sharma B D Gupta · More Details ...

Living in a Materials World: Materials Science Engineering Professional Development for K-12 Educators

Energy Technology Data Exchange (ETDEWEB)

Anne Seifert; Louis Nadelson

2011-06-01

Advances in materials science are fundamental to technological developments and have broad societal impacs. For example, a cellular phone is composed of a polymer case, liquid crystal displays, LEDs, silicon chips, Ni-Cd batteries, resistors, capacitors, speakers, microphones all of which have required advances in materials science to be compacted into a phone which is typically smaller than a deck of cards. Like many technological developments, cellular phones have become a ubiquitous part of society, and yet most people know little about the materials science associated with their manufacture. The probable condition of constrained knowledge of materials science was the motivation for developing and offering a 20 hour fourday course called 'Living in a Materials World.' In addition, materials science provides a connection between our every day experiences and the work of scientists and engineers. The course was offered as part of a larger K-12 teacher professional development project and was a component of a week-long summer institute designed specifically for upper elementary and middle school teachers which included 20 hour content strands, and 12 hours of plenary sessions, planning, and collaborative sharing. The focus of the institute was on enhancing teacher content knowledge in STEM, their capacity for teaching using inquiry, their comfort and positive attitudes toward teaching STEM, their knowledge of how people learn, and strategies for integrating STEM throughout the curriculum. In addition to the summer institute the participating teachers were provided with a kit of about $300 worth of materials and equipment to use to implement the content they learned in their classrooms. As part of this professional development project the participants were required to design and implement 5 lesson plans with their students this fall and report on the results, as part of the continuing education course associated with the project. 'Living in a

Increasing participation in the Earth sciences through engagement of K-12 educators in Earth system science analysis, inquiry and problem- based learning and teaching

Science.gov (United States)

Burrell, S.

2012-12-01

Given low course enrollment in geoscience courses, retention in undergraduate geoscience courses, and granting of BA and advanced degrees in the Earth sciences an effective strategy to increase participation in this field is necessary. In response, as K-12 education is a conduit to college education and the future workforce, Earth science education at the K-12 level was targeted with the development of teacher professional development around Earth system science, inquiry and problem-based learning. An NSF, NOAA and NASA funded effort through the Institute for Global Environmental Strategies led to the development of the Earth System Science Educational Alliance (ESSEA) and dissemination of interdisciplinary Earth science content modules accessible to the public and educators. These modules formed the basis for two teacher workshops, two graduate level courses for in-service teachers and two university course for undergraduate teacher candidates. Data from all three models will be presented with emphasis on the teacher workshop. Essential components of the workshop model include: teaching and modeling Earth system science analysis; teacher development of interdisciplinary, problem-based academic units for implementation in the classroom; teacher collaboration; daily workshop evaluations; classroom observations; follow-up collaborative meetings/think tanks; and the building of an on-line professional community for continued communication and exchange of best practices. Preliminary data indicate increased understanding of Earth system science, proficiency with Earth system science analysis, and renewed interest in innovative delivery of content amongst teachers. Teacher-participants reported increased student engagement in learning with the implementation of problem-based investigations in Earth science and Earth system science thinking in the classroom, however, increased enthusiasm of the teacher acted as a contributing factor. Teacher feedback on open

Manjeet K Sangha

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Manjeet K Sangha. Articles written in Resonance – Journal of Science Education. Volume 9 Issue 8 August 2004 pp 35-45 General Article. Detergents – Zeolites and Enzymes Excel Cleaning Power · B S Sekhon Manjeet K Sangha · More Details Fulltext PDF ...

A K Tyagi

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Tyagi. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 163-168 Thin Films. Carbonaceous alumina films deposited by MOCVD from aluminium acetylacetonate: a spectroscopic ellipsometry study · M P Singh G Raghavan A K Tyagi S A ...

Pravin K Bhadane

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Pravin K Bhadane. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 2 February 1999 pp 8-19 Series Article. Electrostatics in Chemistry - Basic Principles · Shridhar R Gadre Pravin K Bhadane · More Details Fulltext PDF. Volume 4 ...

A K Bandyopadhyay

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Bandyopadhyay. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 121-125 Ceramic Materials. Sintering of nano crystalline silicon carbide doping with aluminium nitride · M S Datta A K Bandyopadhyay B Chaudhuri · More Details Abstract ...

K C Sajjan

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K C Sajjan. Articles written in Bulletin of Materials Science. Volume 34 Issue 7 December 2011 pp 1557-1561. Synthesis, characterization and magnetic properties of polyaniline/-Fe2O3 composites · Syed Khasim S C Raghavendra M Revanasiddappa K C Sajjan Mohana ...

S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.

Science.gov (United States)

Ma, Dongchu; Yu, Huiying; Lin, Di; Sun, Yinghui; Liu, Liping; Liu, Yage; Dai, Bing; Chen, Wei; Cao, Jianping

2009-04-01

Studies on polyploidization of megakaryocytes have been hampered by the lack of synchronized polyploid megakaryocytes. In this study, a relatively synchronized polyploid cell model was successfully established by employing Dami cells treated with nocodazole. In nocodazole-induced cells, cyclin B expression oscillated normally as in diploid cells and polyploid megakaryocytes. By using the nocodazole-induced Dami cell model, we found that 4E-BP1 and Thr421/Ser424 of ribosomal S6 kinase 1(S6K1) were phosphorylated mostly at M-phase in cytoplasm and oscillated in nocodazole-induced polyploid Dami cells, concomitant with increased expression of p27 and cyclin D3. However, phosphorylation of 4E-BP1 and S6K1 on Thr421/Ser424 was significantly decreased in differentiated Dami cells induced by phorbol 12-myristate 13-acetate (PMA), concomitant with increased expression of cyclin D1 and p21 and cyclin D3. Overexpression of the kinase dead form of S6K1 containing the mutation Lys 100 --> Gln in PMA-induced Dami cells increased ploidy whereas overexpression of rapamycin-resistant form of S6K1 containing the mutations Thr421 --> Glu and Ser424 --> Asp significantly dephosphorylated 4E-BP1 and reduced expression of cyclin D1, cyclin D3, p21 and p27, and slightly decreased the ploidy of PMA-induced Dami cells, compared with treatment with PMA alone. Moreover, overexpression of rapamycin-resistant form of S6K1 significantly reversed polyploidization of nocodazole-induced Dami cells. Furthermore, MAP (a novel compound synthesized recently) partly blocked the phosphorylation of S6K1 on Thr421/Ser424 and decreased the expression of p27 and polyploidization in nocodazole-induced Dami cells. Taken together, these data suggested that S6K1/4E-BP1 pathway may play an important role in polyploidization of megakaryocytes. (c) 2008 Wiley-Liss, Inc.

CCQM K6.2 determination of total cholesterol in human serum

Science.gov (United States)

Wise, Stephen A.; Phinney, Karen W.; Duewer, David L.; Sniegoski, Lorna T.; Welch, Michael J.; Pabello, Guiomar; Avila Caldero, Marco A.; Qinde, Liu; Kooi, Lee Tong; Rego, Eliane; Garrido, Bruno; Allegri, Gabriella; de La Cruz, Marcia; Barrabin, Juliana; Puglisi, Celia; Lopez, Eduardo; Lee, Hwashim; Kim, Byungjoo; Delatour, Vincent; Heuillet, Maud; Nammoonnoy, Jintana; Ceyhan Gören, Ahmet; Bilsel, Gokhan; Konopelko, L.; Krylov, A.; Lopushanskaya, E.

2018-01-01

Cholesterol is one of the most frequently measured substances in human blood/serum to assist in assessing the health status of individuals. Because of its clinical significance, CCQM-K6 determination of cholesterol in serum was completed in 2000 as one of the first key comparison (KC) studies performed within the Organic Analysis Working Group (OAWG). The first subsequent KC for cholesterol, CCQM-K6.1, was completed in 2001. Measurements for this second subsequent, CCQM-K6.2, were completed in 2012. These subsequent comparisons were conducted to enable CCQM members that had not participated in earlier studies to demonstrate their capabilities to measure a nonpolar (pKow mass (100 g/mol to 500 g/mol) metabolite in human serum at relatively high concentrations (1 mg/g to 3 mg/g) found in normal populations. Successful participation in CCQM-K6.2 demonstrated capabilities in analysis of complex biological matrices including sample preparation (extraction, derivatization), LC or GC separation, and quantification using an isotope dilution mass spectrometry approach. Normally in a subsequent KC, no key comparison reference value (KCRV) would be established and assessment of performance would be via the deviation of participants' results to the anchor institute's results, adjusted to account for the anchor's performance in the original comparison versus its KCRV. Due to the very long-time period since the original key comparison, the OAWG decided that this did not represent the best approach to assess performance in what is a relatively complex measurement. Given the excellent agreement between the anchor institute's results and robust consensus summary of the participants' values, the reference value for this study was taken as the anchor institute's result and treated as a 'KCRV'. Seven of the nine participants demonstrated agreement with the reference value. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears

FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway

Energy Technology Data Exchange (ETDEWEB)

Huang, Xiongfei, E-mail: xiongfeihuang@hotmail.com [Department of Pathology and Institute of Oncology, Preclinical School, Fujian Medical University, Fuzhou 350108, Fujian (China); Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, Fujian (China); Zeng, Yeting [Department of Pathology and Institute of Oncology, Preclinical School, Fujian Medical University, Fuzhou 350108, Fujian (China); Wang, Xinrui [Department of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350108, Fujian (China); Ma, Xiaoxiao [Department of Diabetes Complications and Metabolism, Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope, CA 91010 (United States); Li, Qianqian; Li, Ningbo; Su, Hongying [Department of Pathology and Institute of Oncology, Preclinical School, Fujian Medical University, Fuzhou 350108, Fujian (China); Huang, Wendong [Department of Diabetes Complications and Metabolism, Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope, CA 91010 (United States)

2016-05-27

The nuclear receptor Farnesoid X Receptor (FXR) is likely a tumor suppressor in liver tissue but its molecular mechanism of suppression is not well understood. In this study, the gene expression profile of human liver cancer cells was investigated by microarray. Bioinformatics analysis of these data revealed that FXR might regulate the mTOR/S6K signaling pathway. This was confirmed by altering the expression level of FXR in liver cancer cells. Overexpression of FXR prevented the growth of cells and induced cell cycle arrest, which was enhanced by the mTOR/S6K inhibitor rapamycin. FXR upregulation also intensified the inhibition of cell growth by rapamycin. Downregulation of FXR produced the opposite effect. Finally, we found that ectopic expression of FXR in SK-Hep-1 xenografts inhibits tumor growth and reduces expression of the phosphorylated protein S6K. Taken together, our data provide the first evidence that FXR suppresses proliferation of human liver cancer cells via the inhibition of the mTOR/S6K signaling pathway. FXR expression can be used as a biomarker of personalized mTOR inhibitor treatment assessment for liver cancer patients. -- Highlights: •FXR inhibits the proliferation of liver cancer cells by prolonging G0/G1 phase. •Microarray results indicate that mTOR-S6k signaling is involved in cellular processes in which FXR plays an important role. •FXR blocks the growth of liver cancer cells via the inhibition of the mTOR/S6K signaling pathway in vitro and in vivo.

FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway

International Nuclear Information System (INIS)

Huang, Xiongfei; Zeng, Yeting; Wang, Xinrui; Ma, Xiaoxiao; Li, Qianqian; Li, Ningbo; Su, Hongying; Huang, Wendong

2016-01-01

The nuclear receptor Farnesoid X Receptor (FXR) is likely a tumor suppressor in liver tissue but its molecular mechanism of suppression is not well understood. In this study, the gene expression profile of human liver cancer cells was investigated by microarray. Bioinformatics analysis of these data revealed that FXR might regulate the mTOR/S6K signaling pathway. This was confirmed by altering the expression level of FXR in liver cancer cells. Overexpression of FXR prevented the growth of cells and induced cell cycle arrest, which was enhanced by the mTOR/S6K inhibitor rapamycin. FXR upregulation also intensified the inhibition of cell growth by rapamycin. Downregulation of FXR produced the opposite effect. Finally, we found that ectopic expression of FXR in SK-Hep-1 xenografts inhibits tumor growth and reduces expression of the phosphorylated protein S6K. Taken together, our data provide the first evidence that FXR suppresses proliferation of human liver cancer cells via the inhibition of the mTOR/S6K signaling pathway. FXR expression can be used as a biomarker of personalized mTOR inhibitor treatment assessment for liver cancer patients. -- Highlights: •FXR inhibits the proliferation of liver cancer cells by prolonging G0/G1 phase. •Microarray results indicate that mTOR-S6k signaling is involved in cellular processes in which FXR plays an important role. •FXR blocks the growth of liver cancer cells via the inhibition of the mTOR/S6K signaling pathway in vitro and in vivo.

B K Singh

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B K Singh. Articles written in Bulletin of Materials Science. Volume 30 Issue 3 June 2007 pp 235-238 Clay Materials. Instrumental characterization of clay by XRF, XRD and FTIR · Preeti Sagar Nayak B K Singh · More Details Abstract Fulltext PDF. Instrumental characterizations ...

K Narasimha Rao

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K Narasimha Rao. Articles written in Bulletin of Materials Science. Volume 26 Issue 2 February 2003 pp 239-245 Thin Films. Studies on thin film materials on acrylics for optical applications · K Narasimha Rao · More Details Abstract Fulltext PDF. Deposition of durable thin film ...

K N Ganeshaiah

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K N Ganeshaiah. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 1 January 1998 pp 36-46 General Article. Love Games that Insects Play - The Evolution of Sexual Behaviours in Insects · K N Ganeshaiah · More Details Fulltext PDF ...

M K Jayaraj

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. M K Jayaraj. Articles written in Bulletin of Materials Science. Volume 25 Issue 3 June 2002 pp 227-230 Thin Films. Transparent conducting zinc oxide thin film prepared by off-axis rf magnetron sputtering · M K Jayaraj Aldrin Antony Manoj Ramachandran · More Details Abstract ...

P K Das

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. P K Das. Articles written in Bulletin of Materials Science. Volume 23 Issue 4 August 2000 pp 249-253 Nitride Ceramics. Optimization of time–temperature schedule for nitridation of silicon compact on the basis of silicon and nitrogen reaction kinetics · J Rakshit P K Das.

AIAA Educator Academy - Mars Rover Curriculum: A 6 week multidisciplinary space science based curriculum

Science.gov (United States)

Henriquez, E.; Bering, E. A.; Slagle, E.; Nieser, K.; Carlson, C.; Kapral, A.

2013-12-01

The Curiosity mission has captured the imagination of children, as NASA missions have done for decades. The AIAA and the University of Houston have developed a flexible curriculum program that offers children in-depth science and language arts learning culminating in the design and construction of their own model rover. The program is called the Mars Rover Model Celebration. It focuses on students, teachers and parents in grades 3-8. Students learn to research Mars in order to pick a science question about Mars that is of interest to them. They learn principles of spacecraft design in order to build a model of a Mars rover to carry out their mission on the surface of Mars. The model is a mock-up, constructed at a minimal cost from art supplies. This project may be used either informally as an after school club or youth group activity or formally as part of a class studying general science, earth science, solar system astronomy or robotics, or as a multi-disciplinary unit for a gifted and talented program. The project's unique strength lies in engaging students in the process of spacecraft design and interesting them in aerospace engineering careers. The project is aimed at elementary and secondary education. Not only will these students learn about scientific fields relevant to the mission (space science, physics, geology, robotics, and more), they will gain an appreciation for how this knowledge is used to tackle complex problems. The low cost of the event makes it an ideal enrichment vehicle for low income schools. It provides activities that provide professional development to educators, curricular support resources using NASA Science Mission Directorate (SMD) content, and provides family opportunities for involvement in K-12 student learning. This paper will describe the structure and organization of the 6 week curriculum. A set of 30 new 5E lesson plans have been written to support this project as a classroom activity. The challenge of developing interactive

K2 & Solar System Science

Science.gov (United States)

Lissauer, Jack

2015-01-01

All of the fields that K2 observes are near the ecliptic plane in order to minimize the spin-up of the spacecraft in response to the effects of solar irradiation. The fields observed by K2 are thus rich in Solar System objects including planets, asteroids and trans-Neptunian objects (TNOs). K2 has already performed observations of Neptune and its large moon Triton, 68 Trojan and Hilda asteroids, 5 TNOs (including Pluto) and Comet C/2013 A1 (Siding Springs). About 10,000 main-belt asteroids that fell into the pixel masks of stars have been serendipitously observed. Observations of small bodies are especially useful for determining rotation periods. Uranus will be observed in a future campaign (C8), as will many more small Solar System bodies. The status of various K2 Solar System studies will be reviewed and placed within the context of our current knowledge of the objects being observed.

Cosmic strings in unified gauge theories

International Nuclear Information System (INIS)

Everett, A.E.

1981-01-01

Some spontaneously broken gauge theories can give rise to stringlike vacuum structures (vortices). It has been pointed out by Vilenkin that in grand unified theories these can be sufficiently massive to have cosmological implications, e.g., in explaining the formation of galaxies. The circumstances in which such structures occur are examined. They do not occur in the simplest grand unified theories, but can occur in some more elaborate models which have been proposed. The cross section for the scattering of elementary particles by strings is estimated. This is used to evaluate the effect of collisions on the dynamics of a collapsing circular string, with particular attention to the question of whether energy dissipation by collision can reduce the rate of formation of black holes by collapsed strings, which may be unacceptably large in models where strings occur. It is found that the effect of collisions is not important in the case of grand unified strings, although it can be important for lighter strings

Unified strength theory and its applications

CERN Document Server

Yu, Mao-Hong

2004-01-01

This is a completely new theory dealing with the yield and failure of materials under multi-axial stresses. It provides a system of yield and failure criteria adopted for most materials, from metallic materials to rocks, concretes, soils, polymers etc. The Unified Strength Theory has been applied successfully to analyse the elastic limit, plastic limit capacities, the dynamic response behavior for some structures under static and moderate impulsive load, and may be implemented in some elasto-plastic finite element computer codes. The Unified Strength Theory is described in detail and by using this theory a series of results can be obtained. The Unified Strength Theory can improve the conservative Mohr-Coulomb Theory, and since intermediate principal stress is not taken into account in the Mohr-Coulomb theory and most experimental data is not pertainable to the Mohr-Coulomb Theory, a considerable economic benefit may be obtained. The book can also increase the effect of most commercial finite element computer ...

Intrinsically restless: Unifying science, writing, and the human condition

Science.gov (United States)

Sissom, Matthew

The field of physics has always fascinated me, but I never possessed the mathematical skills necessary to extend that interest past the point of curiosity. This thesis was set up to explore how I and other writers, specifically Walt Whitman, use(d) the skills we do have to ask and attempt to answer the same cosmic questions normally reserved for scientists overseeing particle collider experiments. In Tao of Physics, Fritjof Capra attempted to blend the principles of Eastern philosophy with the movements associated with modern physics. In doing so, he offers up a few insights into the human desire to "divide the world into separate objects and events" (117), which I believe, when it comes to fiction, greatly influences the audience's interpretive framework. Capra suggests, "To believe that our abstract concepts of separate `things' and `vents' are realities of nature is an illusion" (117). Humans use this division to cope with our everyday environment, yet it is not a fundamental feature of reality but, rather, an abstraction devised by our discriminating and categorizing intellect. It is a coping mechanism, as Capra refers to it, that pins writers in a corner, encouraging them to forms and styles set by their predecessors to better satisfy the "discriminating and categorizing intellect" of their audience. Writers often struggle to achieve a balance between accurately presenting the human condition that, like Capra's description of subatomic particles as "intrinsically restless" (117), changes based on myriad variables and properly structuring their writing to fit a predetermined model. Whitman, a fan of popular science, drew from the scientific world, using his understanding of the interpretive framework, to better craft his poems' metaphors. In "Song of Myself," Whitman suggests that the celebration of one's own existence cannot be separated from the celebration of the universe, "For every atom belonging to me as good belongs to you" (1-3). Whitman's writing

C-MORE Science Kits: Putting Technology in the Hands of K-12 Teachers and Students

Science.gov (United States)

Achilles, K.; Weersing, K.; Daniels, C.; Puniwai, N.; Matsuzaki, J.; Bruno, B. C.

2008-12-01

The Center for Microbial Oceanography: Research and Education (C-MORE) is a NSF Science and Technology Center based at the University of Hawaii. The C-MORE education and outreach program offers a variety of resources and professional development opportunities for science educators, including online resources, participation in oceanography research cruises, teacher-training workshops, mini-grants to incorporate microbial oceanography-related content and activities into their classroom and, most recently, C- MORE science kits. C-MORE science kits provide hands-on classroom, field, and laboratory activities related to microbial oceanography for K-12 students. Each kit comes with complete materials and instructions, and is available free of charge to Hawaii's public school teachers. Several kits are available nationwide. C-MORE science kits cover a range of topics and technologies and are targeted at various grade levels. Here is a sampling of some available kits: 1) Marine Murder Mystery: The Case of the Missing Zooxanthellae. Students learn about the effect of climate change and other environmental threats on coral reef destruction through a murder-mystery experience. Participants also learn how to use DNA to identify a suspect. Grades levels: 3-8. 2) Statistical sampling. Students learn basic statistics through an exercise in random sampling, with applications to microbial oceanography. The laptops provided with this kit enable students to enter, analyze, and graph their data using EXCEL. Grades levels: 6-12. 3) Chlorophyll Lab. A research-quality fluorometer is used to measure the chlorophyll content in marine and freshwater systems. This enables students to compare biomass concentrations in samples collected from various locations. Grades levels: 9-12. 4) Conductivity-Temperature-Depth (CTD). Students predict how certain variables (e.g., temperature, pressure, chlorophyll, oxygen) vary with depth. A CTD, attached to a laptop computer, is deployed into deep water

Crystal Structure and Spectroscopic Characterization of K8(VO)2O(SO4)6:

DEFF Research Database (Denmark)

Rasmussen, Søren Birk; Rasmussen, Rikke Christina; Fehrmann, Rasmus

2003-01-01

Red and yellow dichroistic crystals of a vanadium(V) compound, potassium (mu-oxo, di-mu-suifato)bis(oxodisulfato-vanadate), K-8(VO)(2)O(SO4)(6), have been obtained from the ternary catalytic model melt system K2S2O7-K2SO4-V2O5. By slow cooling of the melt from 420 to 355 degreesC, crystal growth...

Performance Analysis of FSO Links over Unified Gamma-Gamma Turbulence Channels

KAUST Repository

Ansari, Imran Shafique; Yilmaz, Ferkan; Alouini, Mohamed-Slim

2015-01-01

, then, present unified exact closed-form expressions for various statistical characteristics of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system. We capitalize on these unified results to offer unified exact closed

High Current, Low Voltage Power Converter [20kA, 6V] LHC Converter Prototype

CERN Document Server

Jørgensen, H E; Dupaquier, A; Fernqvist, G

1998-01-01

The superconducting LHC accelerator requires high currents (~12.5kA) and relatively low voltages (~10 V) for its magnets. The need to install the power converters underground is the driving force for reduced volume and high efficiency. Moreover, the LHC machine will require a very high level of performance from the power converters, particularly in terms of DC stability, dynamic response and also in matters of EMC. To meet these requirements soft-switching techniques will be used. This paper describes the development of a [20kA,6V] power converter intended as a stable high-current source for D CCT calibration and an evaluation prototype for the future LHC converters. The converter is made with a modular concept with five current sources [4kA,6V] in parallel. The 4kA sources are built as plu g-in modules: a diode rectifier on the AC mains with a damped L-C passive filter, a Zero Voltage Switching inverter working at 20 kHz and an output stage (high frequency transformers, Schottky rectifi ers and output filter...

S K Date

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S K Date. Articles written in Bulletin of Materials Science. Volume 23 Issue 2 April 2000 pp 97-101 Magnetic Materials. Comparison of the irreversible thermomagnetic behaviour of some ferro- and ferrimagnetic systems · P S Anil Kumar P A Joy S K Date · More Details Abstract ...

S K Das

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S K Das. Articles written in Bulletin of Materials Science. Volume 24 Issue 4 August 2001 pp 373-378 Metals and Alloys. Evaluation of solid–liquid interface profile during continuous casting by a spline based formalism · S K Das · More Details Abstract Fulltext PDF. A numerical ...

N K Man

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. N K Man. Articles written in Bulletin of Materials Science. Volume 37 Issue 1 February 2014 pp 19-25. Influence of preparation conditions on superconducting properties of Bi-2223 thin films · N T Mua A Sundaresan N K Man D D Dung · More Details Abstract Fulltext PDF.

Unified electricity market

International Nuclear Information System (INIS)

Anon

2011-01-01

A unified European electricity market means a unification and harmonisation of functioning of the national electricity market into one European Market or into one entity. It gives an opportunity to Slovenske elektrarne to open room for their wider activity within Europe where common rules for cross-boarder trade and markets functioning will apply. (author)

Microstructures and Dehydrogenation Properties of Ball-milled MgH2-K2Ti6O13-Ni Composite Systems

Directory of Open Access Journals (Sweden)

ZHANG Jian

2016-11-01

Full Text Available The K2Ti6O13 whisker separate-doped and K2Ti6O13 whisker and Ni powder multi-doped MgH2 hydrogen storage composite systems were prepared by mechanical milling method. The microstructures and dehydrogenation properties of the prepared samples were characterized by some testing methods such as X-ray diffraction (XRD, scanning electron microscope (SEM and differential scanning calorimeter (DSC. The results show that the K2Ti6O13 whisker not only plays the roles in refining the MgH2 crystalline grain, but also inhibit the agglomeration of MgH2 particles in K2Ti6O13 whisker separate-doped system, which results in the decreased dehydrogenation temperature of MgH2 matrix. When the mass ratio of K2Ti6O13 to MgH2 is 3:7, the improvement effect on dehydrogenation properties of MgH2 is the most remarkable. As compared with pure ball-milled MgH2, the dehydrogenation temperature of MgH2 in K2Ti6O13 whisker separate-doped system is decreased by nearly 75℃. For K2Ti6O13 whisker and Ni powder multi-dopedsystem, the dehydrogenation temperature of MgH2 matrix is further decreased compared to K2Ti6O13 whisker separate-doped one due to the dual effects of refined MgH2 crystalline grain by K2Ti6O13 whisker and destabilized MgH2 lattice by Ni solution. As compared with pure ball-milled MgH2, the dehydrogenation temperature of MgH2 in K2Ti6O13 whisker and Ni powder multi-doped system is decreased by nearly 87℃.

Technical writing practically unified through industry

Science.gov (United States)

Houston, L. S.

1981-01-01

General background details in the development of a university level technical writing program, based upon the writing tasks of the student's occupations, are summarized. Objectives and methods for unifying the courses of study with the needs of industry are discussed. Four academic course divisions, Industries Technologies, in which preparation and training are offered are: Animal, Horticulture, Agriculture, and Agricultural Business. Occupational competence is cited as the main goal for these programs in which technical writing is to be practically unified through industry. Course descriptions are also provided.

Prospects of a Unified Management System

DEFF Research Database (Denmark)

Jørgensen, Tine Herreborg; Simonsen, Gorm

2002-01-01

In this article, the trend among management systems towards a common structure and the inclusion of additional areas of corporate concern (quality, environment, occupational health and safety and social responsibility) is outlined. The article suggests that a large part of the work associated...... with implementing and maintaining standardised management systems can be rationalised by developing a ?unified system?. The unified system is proposed to consist of a common basic standard of general managerial methodology expandable with supplements, which are related to the specific areas of concern...

Unified Bohm criterion

Energy Technology Data Exchange (ETDEWEB)

Kos, L. [LECAD Laboratory, Faculty of Mechanical Engineering, University of Ljubljana, SI-1000 Ljubljana (Slovenia); Tskhakaya, D. D.; Jelić, N. [Institute for Theoretical Physics, Fusion@ÖAW, University of Innsbruck, A-6020 Innsbruck (Austria)

2015-09-15

Recent decades have seen research into the conditions necessary for the formation of the monotonic potential shape in the sheath, appearing at the plasma boundaries like walls, in fluid, and kinetic approximations separately. Although either of these approaches yields a formulation commonly known as the much-acclaimed Bohm criterion (BC), the respective results involve essentially different physical quantities that describe the ion gas behavior. In the fluid approach, such a quantity is clearly identified as the ion directional velocity. In the kinetic approach, the ion behavior is formulated via a quantity (the squared inverse velocity averaged by the ion distribution function) without any clear physical significance, which is, moreover, impractical. In the present paper, we try to explain this difference by deriving a condition called here the Unified Bohm Criterion, which combines an advanced fluid model with an upgraded explicit kinetic formula in a new form of the BC. By introducing a generalized polytropic coefficient function, the unified BC can be interpreted in a form that holds, irrespective of whether the ions are described kinetically or in the fluid approximation.

The Astronomy and Space Science Concept Inventory: Assessment Instruments Aligned with the K-12 National Science Standards

Science.gov (United States)

Sadler, Philip M.

2011-01-01

We report on the development of an item test bank and associated instruments based on those K-12 national standards which involve astronomy and space science. Utilizing hundreds of studies in the science education research literature on student misconceptions, we have constructed 211 unique items that measure the degree to which students abandon such ideas for accepted scientific views. Piloted nationally with 7599 students and their 88 teachers spanning grades 5-12, the items reveal a range of interesting results, particularly student difficulties in mastering the NRC Standards and AAAS Benchmarks. Teachers generally perform well on items covering the standards of the grade level at which they teach, exhibiting few misconceptions of their own. Teachers dramatically overestimate their students’ performance, perhaps because they are unaware of their students’ misconceptions. Examples are given showing how the developed instruments can be used to assess the effectiveness of instruction and to evaluate the impact of professional development activities for teachers.

Unifying Theories of Psychedelic Drug Effects

Directory of Open Access Journals (Sweden)

Link R. Swanson

2018-03-01

Full Text Available How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function.

Unifying Theories of Psychedelic Drug Effects

Science.gov (United States)

Swanson, Link R.

2018-01-01

How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function. PMID:29568270

Scientific Participation at the Poles: K-12 Teachers in Polar Science for Careers and Classrooms

Science.gov (United States)

Crowley, S.; Warburton, J.

2012-12-01

PolarTREC (Teachers and Researchers Exploring and Collaborating) is a National Science Foundation (NSF) funded program in which K-12 teachers participate in hands-on field research experiences in the polar regions. PolarTREC highlights the importance of involving teachers in scientific research in regards to their careers as educators and their ability to engage students in the direct experience of science. To date, PolarTREC has placed over 90 teachers with research teams in the Arctic and Antarctic. Published results of our program evaluation quantify the effect of the field experience on the teachers' use of the real scientific process in the classroom, the improvement in science content taught in classrooms, and the use of non-fiction texts (real data and science papers) as primary learning tools for students. Teachers and students both report an increase of STEM literacy in the classroom content, confidence in science education, as well as a markedly broadened outlook of science as essential to their future. Research conducted with science teams affirms that they are achieving broader impacts when PolarTREC teachers are involved in their expeditions. Additionally, they reported that these teachers making vital contributions to the success of the scientific project.

A Review of Computer Science Resources for Learning and Teaching with K-12 Computing Curricula: An Australian Case Study

Science.gov (United States)

Falkner, Katrina; Vivian, Rebecca

2015-01-01

To support teachers to implement Computer Science curricula into classrooms from the very first year of school, teachers, schools and organisations seek quality curriculum resources to support implementation and teacher professional development. Until now, many Computer Science resources and outreach initiatives have targeted K-12 school-age…

Ghrelin promotes human non-small cell lung cancer A549 cell proliferation through PI3K/Akt/mTOR/P70S6K and ERK signaling pathways.

Science.gov (United States)

Zhu, Jianhua; Yao, Jianfeng; Huang, Rongfu; Wang, Yueqin; Jia, Min; Huang, Yan

2018-04-06

Ghrelin is a gastric acyl-peptide that plays an important role in cell proliferation. In the present study, we explored the role of ghrelin in A549 cell proliferation and the possible molecular mechanisms. We found that ghrelin promotes A549 cell proliferation, knockdown of the growth hormone secretagogue receptor (GHSR) attenuated A549 cell proliferation caused by ghrelin. Ghrelin induced the rapid phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, ERK, mammalian target of rapamycin (mTOR) and P70S6K. PI3K inhibitor (LY 294002), ERK inhibitor (PD98059) and mTOR inhibitor (Rapamycin) inhibited ghrelin-induced A549 cell proliferation. Moreover, GHSR siRNA inhibited phosphorylation of PI3K, Akt, ERK, mTOR and P70S6K induced by ghrelin. Akt and mTOR/P70S6K phosphorylation was inhibited by LY 294002 but not by PD98059. These results indicate that ghrelin promotes A549 cell proliferation via GHSR-dependent PI3K/Akt/mTOR/P70S6K and ERK signaling pathways. Copyright © 2018 Elsevier Inc. All rights reserved.

From neutron science project to J-PARC. From the viewpoint of JAERI

International Nuclear Information System (INIS)

Oyama, Yukio

2006-01-01

Japan Atomic Energy Research Institute (JAERI), at present Japan Atomic Energy Agency (JAEA), has been developing particle accelerators since its establishment in 1956 for obtaining basic data on the neutron. Also reactor-based neutron sciences have been developed at JAERI/JAEA. Under the so-called omega project which was started in 1988, JAERI/JAEA has been conducting researches on Engineering Test Accelerator for the nuclear transmutation and has built a Basic Test Accelerator. In 1996, a special team for neutron science promotion was organized and pushed R and D works on proton accelerators, targets, neutron engineering, radiation safety and so on. Integration of proton accelerator projects at JAERI and KEK (Institute for High Energy Physics) was proposed in 1998, and both institutes agreed to establish a unified proton accelerator facility, J-PARC. JAEA is promoting the industrial application of neutrons. Also the research on nuclear transmutation at J-PARC, which is not endorsed yet, is an essential objective for JAEA. (K.Y.)

Anil K Rajvanshi

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Anil K Rajvanshi. Articles written in Resonance – Journal of Science Education. Volume 12 Issue 3 March 2007 pp 4-12 General Article. Nikola Tesla – The Creator of the Electric Age · Anil K Rajvanshi · More Details Fulltext PDF. Volume 13 Issue 7 July 2008 pp ...

K S Valdiya

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K S Valdiya. Articles written in Resonance – Journal of Science Education. Volume 1 Issue 5 May 1996 pp 19-28 General Article. River Piracy Saraswati that Disappeared · K S Valdiya · More Details Fulltext PDF. Volume 1 Issue 8 August 1996 pp 55-63 General ...

A K Das

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Das. Articles written in Bulletin of Materials Science. Volume 28 Issue 2 April 2005 pp 131-136 Fly Ash. Some studies on the reaction between fly ash and lime · A Basumajumdar A K Das N Bandyopadhyay S Maitra · More Details Abstract Fulltext PDF. The reaction between ...

Operation Unified Protector

DEFF Research Database (Denmark)

Buhl, Kenneth Øhlenschlæger

2012-01-01

Formålet med denne artikel er at se nærmere på erfaringerne fra den maritime kampagne under den militære indsats i konflikten i Libyen i 2011, som i NATO regi blev kendt som Operation Unified Protector (OUP). Dækningen i de danske medier fokuserede primært på luftkampagnen, hvilket må tilskrives,...

GUDM: Automatic Generation of Unified Datasets for Learning and Reasoning in Healthcare.

Science.gov (United States)

Ali, Rahman; Siddiqi, Muhammad Hameed; Idris, Muhammad; Ali, Taqdir; Hussain, Shujaat; Huh, Eui-Nam; Kang, Byeong Ho; Lee, Sungyoung

2015-07-02

A wide array of biomedical data are generated and made available to healthcare experts. However, due to the diverse nature of data, it is difficult to predict outcomes from it. It is therefore necessary to combine these diverse data sources into a single unified dataset. This paper proposes a global unified data model (GUDM) to provide a global unified data structure for all data sources and generate a unified dataset by a "data modeler" tool. The proposed tool implements user-centric priority based approach which can easily resolve the problems of unified data modeling and overlapping attributes across multiple datasets. The tool is illustrated using sample diabetes mellitus data. The diverse data sources to generate the unified dataset for diabetes mellitus include clinical trial information, a social media interaction dataset and physical activity data collected using different sensors. To realize the significance of the unified dataset, we adopted a well-known rough set theory based rules creation process to create rules from the unified dataset. The evaluation of the tool on six different sets of locally created diverse datasets shows that the tool, on average, reduces 94.1% time efforts of the experts and knowledge engineer while creating unified datasets.

Teaching and Learning about Complex Systems in K-12 Science Education: A Review of Empirical Studies 1995-2015

Science.gov (United States)

Yoon, Susan A.; Goh, Sao-Ee; Park, Miyoung

2018-01-01

The study of complex systems has been highlighted in recent science education policy in the United States and has been the subject of important real-world scientific investigation. Because of this, research on complex systems in K-12 science education has shown a marked increase over the past two decades. In this systematic review, we analyzed 75…

designing a framework for a unified electronic identity system

African Journals Online (AJOL)

DJFLEX

In this paper, a Unified Identity System is proposed where single electronic identity (eID) is issued that can be used ... online commerce and public sector organizations. Because ..... SearchUnifiedCommunications.com Definitions, Access date.

Unified User Interface to Support Effective and Intuitive Data Discovery, Dissemination, and Analysis at NASA GES DISC

Science.gov (United States)

Petrenko, M.; Hegde, M.; Bryant, K.; Johnson, J. E.; Ritrivi, A.; Shen, S.; Volmer, B.; Pham, L. B.

2015-01-01

Goddard Earth Sciences Data and Information Services Center (GES DISC) has been providing access to scientific data sets since 1990s. Beginning as one of the first Earth Observing System Data and Information System (EOSDIS) archive centers, GES DISC has evolved to offer a wide range of science-enabling services. With a growing understanding of needs and goals of its science users, GES DISC continues to improve and expand on its broad set of data discovery and access tools, sub-setting services, and visualization tools. Nonetheless, the multitude of the available tools, a partial overlap of functionality, and independent and uncoupled interfaces employed by these tools often leave the end users confused as of what tools or services are the most appropriate for a task at hand. As a result, some the services remain underutilized or largely unknown to the users, significantly reducing the availability of the data and leading to a great loss of scientific productivity. In order to improve the accessibility of GES DISC tools and services, we have designed and implemented UUI, the Unified User Interface. UUI seeks to provide a simple, unified, and intuitive one-stop shop experience for the key services available at GES DISC, including sub-setting (Simple Subset Wizard), granule file search (Mirador), plotting (Giovanni), and other services. In this poster, we will discuss the main lessons, obstacles, and insights encountered while designing the UUI experience. We will also present the architecture and technology behind UUI, including NodeJS, Angular, and Mongo DB, as well as speculate on the future of the tool at GES DISC as well as in a broader context of the Space Science Informatics.

The Impact of a "Framework"-Aligned Science Professional Development Program on Literacy and Mathematics Achievement of K-3 Students

Science.gov (United States)

Paprzycki, Peter; Tuttle, Nicole; Czerniak, Charlene M.; Molitor, Scott; Kadervaek, Joan; Mendenhall, Robert

2017-01-01

This study investigates the effect of a Framework-aligned professional development program at the PreK-3 level. The NSF funded program integrated science with literacy and mathematics learning and provided teacher professional development, along with materials and programming for parents to encourage science investigations and discourse around…

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science; Volume 109; Issue 3. Volume 109, Issue 3. September 2000, pages 315-391. pp 315-328. Ocean circulation in the tropical Indo-Pacific during early Pliocene (5.6 - 4.2 Ma): Paleobiogeographic and isotopic evidence · M S Srinivasan D K Sinha · More Details Abstract ...

Unified theory of effective interaction

Energy Technology Data Exchange (ETDEWEB)

Takayanagi, Kazuo, E-mail: k-takaya@sophia.ac.jp

2016-09-15

We present a unified description of effective interaction theories in both algebraic and graphic representations. In our previous work, we have presented the Rayleigh–Schrödinger and Bloch perturbation theories in a unified fashion by introducing the main frame expansion of the effective interaction. In this work, we start also from the main frame expansion, and present various nonperturbative theories in a coherent manner, which include generalizations of the Brandow, Brillouin–Wigner, and Bloch–Horowitz theories on the formal side, and the extended Krenciglowa–Kuo and the extended Lee–Suzuki methods on the practical side. We thus establish a coherent and comprehensive description of both perturbative and nonperturbative theories on the basis of the main frame expansion.

The Windows to the Universe Project: Using the Internet to Support K-12 Science Education

Science.gov (United States)

Gardiner, L.; Johnson, R.; Bergman, J.; Russell, R.; Genyuk, J.; La Grave, M.

2003-12-01

The World Wide Web can be a powerful tool for reaching the public as well as students and teachers around the world, supporting both formal and informal science education. The Windows to the Universe Project, initiated in 1995, provides a case study of approaches for the use of the web to support earth and space science education and literacy efforts. Through the use of innovative approaches such as easy to use design, multi-level content, and science concepts presented in a broader background context that includes connections to culture and the humanities, Windows to the Universe is an accessible format for individuals of various ages and learning styles. A large global audience regularly uses the web site to learn about earth and space science as well as related humanities content such as myths from around the world. User surveys show that the site has over 4 millions users per year, 65 percent of which are K-12 teachers and students. Approximately 46 percent of users access the site once per week or more. Recently, we have had the opportunity to expand our efforts while we continue to update existing content based on new scientific findings and events. Earth science content on Windows to the Universe is currently growing with a new geology section and development efforts are underway to expand our space weather content with a new curriculum. Educational games allow users to learn about space in a playful context, and an online journaling tool further integrates literacy into the learning experience. In addition, we are currently translating the entire Windows to the Universe web site into Spanish. We have included educators in the project as co-designers from its inception, and by aggressively utilizing and providing professional development opportunities for teachers, the web site is now used in thousands of classrooms around the world. In the past year we have continued to support K-12 educators by adding to our suite of classroom activities and leading

AC susceptibility and NQR measurements on CeCu6 below 5 mK

International Nuclear Information System (INIS)

Jin, C.; Lee, D.M.; Pollack, L.; Smith, E.N.; Markert, J.T.; Maple, M.B.; Hinks, D.G.

1994-01-01

We have measured the zero field ac magnetic susceptibility of single and polycrystalline CeCu 6 samples down to 100 μK. For the single crystal sample, the susceptibility shows pronounced anisotropic behavior with respect to the crystal orientation. At ∼3 mK the susceptibility along two different crystal orientations shows a broad peak, and at 500 μK the susceptibility shows a second peak along one orientation and a plateau along the other. The susceptibility of the polycrystalline sample has a similar peak at 3 mK. NQR measurements are under way to study the Cu nuclear spin system in this compound in order to gain additional information about the nature of the peaks. (orig.)

UniFIeD Univariate Frequency-based Imputation for Time Series Data

OpenAIRE

Friese, Martina; Stork, Jörg; Ramos Guerra, Ricardo; Bartz-Beielstein, Thomas; Thaker, Soham; Flasch, Oliver; Zaefferer, Martin

2013-01-01

This paper introduces UniFIeD, a new data preprocessing method for time series. UniFIeD can cope with large intervals of missing data. A scalable test function generator, which allows the simulation of time series with different gap sizes, is presented additionally. An experimental study demonstrates that (i) UniFIeD shows a significant better performance than simple imputation methods and (ii) UniFIeD is able to handle situations, where advanced imputation methods fail. The results are indep...

Project for the Space Science in Moscow State University of Geodesy and Cartography (MIIGAiK)

Science.gov (United States)

Semenov, M.; Oberst, J.; Malinnikov, V.; Shingareva, K.; Grechishchev, A.; Karachevtseva, I.; Konopikhin, A.

2012-04-01

Introduction: Based on the proposal call of the Government of Russian Federation 40 of international scientists came to Russia for developing and support-ing research capabilities of national educational institutions. Moscow State University of Geodesy and Cartography (MIIGAiK) and invited scientist Prof. Dr. Jurgen Oberst were awarded a grant to establish a capable research facility concerned with Planetary Geodesy, Cartography and Space Exploration. Objectives: The goals of the project are to build laboratory infrastructure, and suitable capability for MIIGAiK to participate in the planning, execution and analyses of data from future Russian planetary mis-sions and also to integrate into the international science community. Other important tasks are to develop an attractive work place and job opportunities for planetary geodesy and cartography students. For this purposes new MIIGAiK Extraterrestrial Laboratory (MExLab) was organized. We involved professors, researchers, PhD students in to the projects of Moon and planets exploration at the new level of Russian Space Science development. Main results: MExLab team prepare data for upcom-ing Russian space missions, such as LUNA-GLOB and LUNA-RESOURSE. We established cooperation with Russian and international partners (IKI, ESA, DLR, and foreign Universities) and actively participated in international conferences and workshops. Future works: For the future science development we investigated the old Soviet Archives and received the access to the telemetry data of the Moon rovers Lunokhod-1 and Lunokhod-2. That data will be used in education purposes and could be the perfect base for the analysis, development and support in new Russian and international missions and especially Moon exploration projects. MExLab is open to cooperate and make the consortiums for science projects for the Moon and planets exploration. Acknowledgement: Works are funded by the Rus-sian Government (Project name: "Geodesy, cartography and the

Yeast β-1,6-glucan is a primary target for the Saccharomyces cerevisiae K2 toxin.

Science.gov (United States)

Lukša, Juliana; Podoliankaitė, Monika; Vepštaitė, Iglė; Strazdaitė-Žielienė, Živilė; Urbonavičius, Jaunius; Servienė, Elena

2015-04-01

Certain Saccharomyces cerevisiae strains secrete different killer proteins of double-stranded-RNA origin. These proteins confer a growth advantage to their host by increasing its survival. K2 toxin affects the target cell by binding to the cell surface, disrupting the plasma membrane integrity, and inducing ion leakage. In this study, we determined that K2 toxin saturates the yeast cell surface receptors in 10 min. The apparent amount of K2 toxin, bound to a single cell of wild type yeast under saturating conditions, was estimated to be 435 to 460 molecules. It was found that an increased level of β-1,6-glucan directly correlates with the number of toxin molecules bound, thereby impacting the morphology and determining the fate of the yeast cell. We observed that the binding of K2 toxin to the yeast surface receptors proceeds in a similar manner as in case of the related K1 killer protein. It was demonstrated that the externally supplied pustulan, a poly-β-1,6-glucan, but not the glucans bearing other linkage types (such as laminarin, chitin, and pullulan) efficiently inhibits the K2 toxin killing activity. In addition, the analysis of toxin binding to the intact cells and spheroplasts confirmed that majority of K2 protein molecules attach to the β-1,6-glucan, rather than the plasma membrane-localized receptors. Taken together, our results reveal that β-1,6-glucan is a primary target of K2 toxin and is important for the execution of its killing property. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

k c anjaneya

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K C ANJANEYA. Articles written in Bulletin of Materials Science. Volume 39 Issue 5 September 2016 pp 1279-1284. Structural, electrical and electrochemical studies of LiNi 0.4 M 0.1 Mn 1.5 O 4 ( M = Co, Mg) solid solutions for lithium ion battery · G P NAYAKA K V PAI J ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 36; Issue 6. Self-assembling behaviour of Pt nanoparticles onto surface of TiO2 and their resulting photocatalytic activity. M Qamar Ashok K Ganguli. Volume 36 Issue 6 November 2013 pp 945-951 ...

Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats.

Science.gov (United States)

Jiang, Xiaoyu; Tao, Huiren; Qiu, Cuiting; Ma, Xiaolei; Li, Shan; Guo, Xian; Lv, Anlin; Li, Huan

2016-09-05

The aim of this study was to investigate the effect of vitamin K2 on aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. A calcification model was established by administering 3mg/g warfarin to rats. Rats were divided into 9 groups: control group (0W, 4W, 6W and 12W groups), 4W calcification group, 6W calcification group, 12W calcification group, 6W calcification+6W normal group and 6W calcification+6W vitamin K2 group. Alizarin red S staining measured aortic calcium depositions; alkaline phosphatase activity in serum was measured by a kit; apoptosis was evaluated by TUNEL assay; protein expression levels of Gas6, Axl, phosphorylated Akt (p-Akt), and Bcl-2 were determined by western blotting. The calcium content, calcium depositions, ALP activity and apoptosis were significantly higher in the calcification groups than control group. Gas6, Axl, p-Akt and Bcl-2 expression was lower in the calcification group than control group. 100μg/g vitamin K2 treatment decreased calcium depositions, ALP activity and apoptosis significantly, but increased Gas6, Axl, p-Akt and Bcl-2 expression. 100μg/g vitamin K2 reversed 44% calcification. Pearson correlation analysis showed a positive correlation between formation calcification and apoptosis (R(2)=0.8853, PK2 can inhibit warfarin-induced aortic calcification and apoptosis. The regression of aortic calcification by vitamin K2 involved the Gas6/Axl axis. This data may provide a theoretical basis for future clinical treatments for aortic calcification. Copyright © 2016 Elsevier B.V. All rights reserved.

Against integration - Why evolution cannot unify the social sciences

NARCIS (Netherlands)

Derksen, M

A lack of integration is often identified as a fundamental problem in psychology and the social sciences. It is thought that only through increased cooperation among the various disciplines and subdisciplines, and integration of their different theoretical approaches, can psychology and the social

Blunting the tensions between informal and formal education in science : reforming the relationship between the school and the science museum in Greece

OpenAIRE

Koliopoulos, Demetris

2003-01-01

In this paper, I explore the relationship between formal and informal approaches to science education as mechanisms for dissemination of scientific knowledge. I then posit the combination of specific characteristics from the two approaches into a unified process of non-formal science education. In the second part of the paper, I describe the different types of science museum and present a taxonomy with respect to their educational mission. Finally, I describe the role of the...

Preparation and photocatalytic property of potassium niobate K6Nb10.8O30

International Nuclear Information System (INIS)

Zhang Gaoke; Zou Xi; Gong Jie; He Fangsheng; Zhang Hao; Zhang Qiang; Liu Ying; Yang Xia; Hu Bo

2006-01-01

The TB-type potassium niobate K 6 Nb 10.8 O 30 was synthesized by a simple solid-state reaction method. Scanning electron microscope (SEM) and X-ray diffractometer (XRD) were used to characterize the structure of the photocatalyst. The photocatalyst K 6 Nb 10.8 O 30 shows high photocatalytic activity to photodegrade acid red G under UV irradiation. The influences of catalyst dosage, initial concentration of acid red G on the photocatalytic reaction were investigated. The kinetics of photocatalytic degradation of acid red G follows the first order kinetics

Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

Directory of Open Access Journals (Sweden)

Chen Y

2015-01-01

Full Text Available Yongzhu Chen,1 Chengkang Tang,2 Jie Zhang,2 Meng Gong,3 Bo Su,2 Feng Qiu4 1Periodical Press, 2Core Facility of West China Hospital, 3Laboratory of Endocrinology and Metabolism, West China Hospital, 4Laboratory of Anaesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Background: Finding a suitable delivery system to improve the water solubility of hydrophobic drugs is a critical challenge in the development of effective formulations. In this study, we used A6K, a self-assembling surfactant-like peptide, as a carrier to encapsulate and deliver hydrophobic pyrene.Methods: Pyrene was mixed with A6K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well as the pyrene release profile.Results: The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A6K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers. The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A6K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells.Conclusion: A6K could be further exploited as a promising delivery system for hydrophobic drugs. Keywords: pyrene, self-assembling peptide, micelles, nanofibers, drug delivery  

Unified SU(4) color models in ten dimensions

International Nuclear Information System (INIS)

Hanlon, B.E.; Joshi, G.C.

1992-01-01

Some aspects of constructing unified models with SU(4) as the color group via a unifying group defined in ten dimensions are examined. Four dimensional theories are recovered using the Coset Space Dimensional Reduction scheme. Candidate models are considered in order to highlight some of the difficulties in constructing realistic four dimensional theories. 30 refs

Coset realization of unifying W-algebras

International Nuclear Information System (INIS)

Blumenhagen, R.; Huebel, R.

1994-06-01

We construct several quantum coset W-algebras, e.g. sl(2,R)/U(1) and sl(2,R)+sl(2,R)/sl(2,R), and argue that they are finitely nonfreely generated. Furthermore, we discuss in detail their role as unifying W-algebras of Casimir W-algebras. We show that it is possible to give coset realizations of various types of unifying W-algebras, e.g. the diagonal cosets based on the symplectic Lie algebras sp(2n) realize the unifying W-algebras which have previously been introduced as 'WD -n '. In addition, minimal models of WD -n are studied. The coset realizations provide a generalization of level-rank-duality of dual coset pairs. As further examples of finitely nonfreely generated quantum W-algebras we discuss orbifolding of W-algebras which on the quantum level has different properties than in the classical case. We demonstrate in some examples that the classical limit according to Bowcock and Watts of these nonfreely finitely generated quantum W-algebras probably yields infinitely nonfreely generated classical W-algebras. (orig.)

Proton decay in grand unified theories

International Nuclear Information System (INIS)

Lucha, W.

1984-01-01

Interactions which violate the conservation of baryon and lepton number represent an intrinsic part of all grand unified theories (GUTs) of strong and electroweak interactions. These new interactions - predicted within the framework of GUTs - generate B and L violating four-fermion interactions via the exchange of superheavy particles which cannot be ascribed a well-defined baryon or lepton number. The effective coupling constant of these four-fermion interactions might be large enough to make the proton decay detectable by the present generation of experiments. In this review the basic concepts of conventional as well as supersymmetric GUTs relevant for proton decay are sketched. The baryon number violating sector of grand unified theories is discussed in more detail. Special emphasis is laid on the various selection rules arising as consequences of low-energy gauge invariance and supersymmetry for proton decay. These selection rules already determine the coarse pattern of the resulting decay modes and branching ratios without any reference to or detailed knowledge of the underlying grand unified theory. Finally the numerous theoretical predictions are summarized and confronted with experiment. (Author)

Mosquito cell line C6/36 shows resistence to Cyt1Aa6

Czech Academy of Sciences Publication Activity Database

Zhang, L.; Huang, E.; Tang, B.; Guan, X.; Gelbič, Ivan

2012-01-01

Roč. 50, č. 4 (2012), s. 265-269 ISSN 0019-5189 R&D Projects: GA MŠk 2B08003 Grant - others:National Nature Science Foundation of China(CN) 31071745; Science Foundation of the Ministry of Education of China(CN) 20093515110010; Science Foundation of the Ministry of Education of China(CN) 20093515120010; Transformation Fund for Agricultural Science and Technology Achievements(CN) 2010GB2C400212; Fujian Colleges and Universities for the Development of the West Strait(CN) 0b08b005 Institutional research plan: CEZ:AV0Z50070508 Keywords : Bacillus thuringiensis * C6/36 cells * indirect immunofluorescence assay Subject RIV: ED - Physiology Impact factor: 1.195, year: 2012 http://nopr.niscair.res.in/bitstream/123456789/13748/1/IJEB%2050(4)%20265-269.pdf

Semiotics, Information Science, Documents and Computers.

Science.gov (United States)

Warner, Julian

1990-01-01

Discusses the relationship and value of semiotics to the established domains of information science. Highlights include documentation; computer operations; the language of computing; automata theory; linguistics; speech and writing; and the written language as a unifying principle for the document and the computer. (93 references) (LRW)

The nano-science of C sub 6 0 molecule

CERN Document Server

Rafii-Tabar, H

2002-01-01

Over the past few years, nano-science and its associated nano-technology have emerged into prominence in research institutions across the world. They have brought about new scientific and engineering paradigms, allowing for the manipulation of single atoms and molecules, designing and fabricating new materials, atom-by-atom, and devices that operate on significantly reduced time and length scales. One important area of research in nano-science and nano technology is carbon-based physics in the form of fullerene physics. The C sub 6 0 molecule, and other cage-like fullerenes, together with carbon nano tubes provide objects that can be combined to generate three-dimensional functional structures for use in the anticipated nano-technology of future. The unique properties of C sub 6 0 can also be exploited in designing nano-phase thin films with applications in nano-scope device technology and processes such as nano-lithography. This requires a deep understanding of the highly complex process of adsorption of thi...

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

Directory of Open Access Journals (Sweden)

Mark A. Smith

2015-04-01

Full Text Available Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic S6K1 signaling on energy homeostasis and the cellular mechanisms underlying these roles are unclear. We therefore inactivated S6K1 in pro-opiomelanocortin (POMC and agouti-related protein (AgRP neurons, key regulators of energy homeostasis, but in contrast to the current view, we found no evidence that S6K1 regulates food intake and bodyweight. In contrast, S6K1 signaling in POMC neurons regulated hepatic glucose production and peripheral lipid metabolism and modulated neuronal excitability. S6K1 signaling in AgRP neurons regulated skeletal muscle insulin sensitivity and was required for glucose sensing by these neurons. Our findings suggest that S6K1 signaling is not a general integrator of energy homeostasis in the mediobasal hypothalamus but has distinct roles in the regulation of glucose homeostasis by POMC and AgRP neurons.

Specific heat measurements of TiB2 and 6LiF from 0.5 to 30 K

International Nuclear Information System (INIS)

Lang, Brian E.; Donaldson, Marcus H.; Woodfield, Brian F.; Burger, Arnold; Roy, Utupal N.; Lamberti, Vincent; Bell, Zane W.

2005-01-01

The specific heats of TiB 2 and 6 LiF have been measured from 0.5 to 30 K as part of a larger project in the construction of a neutron spectrometer. For this application, the measured specific heats were used to extrapolate the specific heats down to 0.1 K with lattice, electronic, and Schottky equations for the respective samples. The resultant specific heat values at 0.1 K for TiB 2 and 6 LiF are 4.08 x 10 -4 ± 0.27 x 10 -4 J/K/mol and 9.19 x 10 -9 ± 0.15 x 10 -9 J/K/mol, respectively

Unified MTF for scintillator-coupled CMOS sensor

International Nuclear Information System (INIS)

Kim, Kwang Hyun; Kang, Dong-Wan; Kim, Dong Ki; Kim, Yong-Kyun

2007-01-01

The spatial resolution of scintillator-coupled CMOS sensor has been investigated from intrinsic sensor Modulation Transfer Function (MTF) to system MTF for the conditions of the digital radiography. For the intrinsic sensor MTF, the geometric MTF (gMTF) and the unified MTF (uMTF) were compared by analytic calculations for various pixel sizes. The effects of the initial dark signal of the sensor were considered in the calculation of the uMTF and reflected in a newly developed semi-empirical model. The measured system MTF and the calculated system MTF including semi-empirical model were compared under radiography conditions of 28 and 80 kVp. From the results, the calculated system MTF reflecting the dark-signal contribution on the sensor resolution did fit for the measured system resolution, and the higher the fraction of an initial dark signal to an output signal in response to X-ray exposure showed more degradation of the system resolution even with same scintillator and sensor

Optical anomaly in artificial cubic hieratite, K2[SiF6

NARCIS (Netherlands)

Göbel, Ole; ten Elshof, Johan E.; Kaminsky, W.; Hannss, M.

2015-01-01

Crystals of K2[SiF6] were grown in agar gel, silica gel and jelly. Crystals grown in agar gel or jelly exhibit birefringence and consist of six double refracting growth sectors, each having the shape of a tetragonal pyramid. Nevertheless, the structure of the crystals from agar gel could be refined

k-Cosymplectic Classical Field Theories: Tulczyjew and Skinner-Rusk Formulations

Science.gov (United States)

Rey, Angel M.; Román-Roy, Narciso; Salgado, Modesto; Vilariño, Silvia

2012-06-01

The k-cosymplectic Lagrangian and Hamiltonian formalisms of first-order classical field theories are reviewed and completed. In particular, they are stated for singular and almost-regular systems. Subsequently, several alternative formulations for k-cosymplectic first-order field theories are developed: First, generalizing the construction of Tulczyjew for mechanics, we give a new interpretation of the classical field equations. Second, the Lagrangian and Hamiltonian formalisms are unified by giving an extension of the Skinner-Rusk formulation on classical mechanics.

k-Cosymplectic Classical Field Theories: Tulczyjew and Skinner–Rusk Formulations

International Nuclear Information System (INIS)

Rey, Angel M.; Román-Roy, Narciso; Salgado, Modesto; Vilariño, Silvia

2012-01-01

The k-cosymplectic Lagrangian and Hamiltonian formalisms of first-order classical field theories are reviewed and completed. In particular, they are stated for singular and almost-regular systems. Subsequently, several alternative formulations for k-cosymplectic first-order field theories are developed: First, generalizing the construction of Tulczyjew for mechanics, we give a new interpretation of the classical field equations. Second, the Lagrangian and Hamiltonian formalisms are unified by giving an extension of the Skinner–Rusk formulation on classical mechanics.

Preparing K-8 Teachers to Conduct Inquiry Oriented Science Education

Science.gov (United States)

Gross, N. A.; Garik, P.; Nolan, M. D.; Winrich, C.; Derosa, D.; Duffy, A.; Jariwala, M.; Konjoian, B.

2010-12-01

The need for STEM professional development for K-8 teachers is well documented. Such professional development promises broad impact, but it must have a positive effect on teachers’ knowledge and skills: 1) a focus on content knowledge, 2) opportunities for active learning, and 3) coherence with other activities. However, sustained impact is only achieved through intensive professional development. In response to the need for science education courses for K-8 teachers, for the past three years, the School of Education and the Department of Physics have collaborated to offer K-8 teachers science content courses of extended duration (75 contact hours) that emphasize inquiry based learning and investigation. The School of Education graduate courses have consisted of five three-hour meetings during the months of May and June, and a two week intensive period in July when the participants come for six hours per day. The alignment of these courses with inquiry teaching was confirmed using the Reformed Teaching Observation Protocol (RTOP). Courses offered in this format have been: --Immersion in Green Energy (IGE) -alternative sources of energy and how electricity is generated (75 teachers over the last 3 years), --Immersion in Global Energy Distribution (IGED) -understanding global climate as an outcome of insolation, convection, and radiation (27 teachers over the last 2 years) The Immersion courses cover a spectrum for inquiry learning that begins with introduction to equipment and experiments through guided discovery and culminates with students taking responsibility for defining and completing their own investigative projects. As a specific example, we consider here the IGED course. For IGED, the first five sessions are devoted to content and learning to use experimental equipment such as digital data collection probes to measure temperature, CO2 and salinity. Content addressed during these sessions include the differentiation between conduction, convection, and

What Did They Take Away?: Examining Newly Qualified U.S. Teachers' Visions of Learning and Teaching Science in K-8 Classrooms

Science.gov (United States)

Roberts-Harris, Deborah

2014-01-01

This study investigated newly qualified K-8 teachers' visions of science learning and teaching after they had completed preparation in a science teaching methods course I taught. What visions of science learning and teaching were these newly qualified teachers taking away from my course? How did these visions compare with those advocated by reform…

A unified transmission loss allocation method

International Nuclear Information System (INIS)

Ding, Qifeng; Abur, Ali

2007-01-01

A new unified method which allocates transmission losses either to buses in a pool market or to individual transactions in a bilateral contract market is presented in this paper. A detailed derivation of the method is given. A bus-loss matrix and a transaction-loss matrix are developed to show the interactions between bus injections and transactions. It is further demonstrated that the ''Physical-power-flow-based'' method can be obtained as an approximation of this unified approach under certain simplifying assumptions. Test systems are used to illustrate how the proposed method behaves under different possible scenarios. (author)

Obtaining Material Data for Heat Treatment Simulation of Casr Alloy Parts with Unified Models

DEFF Research Database (Denmark)

Bellini, Anna; Thorborg, Jesper; Hattel, Jesper

2004-01-01

subjected to high temperature. In this paper a two-state variables unified model is applied in order to simulate creep behavior and time-dependent metallurgical changes. The fundamental assumption of the unified theory is that creep and viscoplasticity, which are both irreversible strains developed because...... study. The results obtained for the simulation of tensile tests and of creep tests are compared with experimental curves, showing a good agreement.......The objective of this work, which is part of the IDEAL (Integrated Development Routes for Optimized Cast Aluminium Components) project, financed by the EU in frame work 6 and born in collaboration with the automobile and foundry industries, is to simulate creep behavior of aluminum cast samples...

Deja vu: The Unified Command Plan of the Future Revisited

Science.gov (United States)

2011-05-19

Approved for Public Release; Distribution is Unlimited Déjà vu : The Unified Command Plan of the Future Revisited A Monograph by Lieutenant...DD-MM-YYYY) 19-05-2011 2. REPORT TYPE Monograph 3. DATES COVERED (From - To) JUL 2010 – MAY 2011 4. TITLE AND SUBTITLE Déjà vu : The Unified...i SCHOOL OF ADVANCED MILITARY STUDIES MONOGRAPH APPROVAL Lieutenant Colonel Edward Francis Martignetti Title of Monograph: Déjà vu : The Unified

Integral Representation of the Pictorial Proof of Sum of [superscript n][subscript k=1]k[superscript 2] = 1/6n(n+1)(2n+1)

Science.gov (United States)

Kobayashi, Yukio

2011-01-01

The pictorial proof of the sum of [superscript n][subscript k=1] k[superscript 2] = 1/6n(n+1)(2n+1) is represented in the form of an integral. The integral representations are also applicable to the sum of [superscript n][subscript k-1] k[superscript m] (m greater than or equal to 3). These representations reveal that the sum of [superscript…

A Unified Model Exploring Parenting Practices as Mediators of Marital Conflict and Children's Adjustment

Science.gov (United States)

Coln, Kristen L.; Jordan, Sara S.; Mercer, Sterett H.

2013-01-01

We examined positive and negative parenting practices and psychological control as mediators of the relations between constructive and destructive marital conflict and children's internalizing and externalizing problems in a unified model. Married mothers of 121 children between the ages of 6 and 12 completed questionnaires measuring marital…

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. N K Thakur. Articles written in Journal of Earth System Science. Volume 118 Issue 1 February 2009 pp 11-26. Assessment of different topographic corrections in AWiFS satellite imagery of Himalaya terrain · V D Mishra J K Sharma K K Singh N K Thakur M Kumar.

Models of science dynamics encounters between complexity theory and information sciences

CERN Document Server

Börner, Katy; Besselaar, Peter

2012-01-01

Models of science dynamics aim to capture the structure and evolution of science. They are developed in an emerging research area in which scholars, scientific institutions and scientific communications become themselves basic objects of research. In order to understand phenomena as diverse as the structure of evolving co-authorship networks or citation diffusion patterns, different models have been developed. They include conceptual models based on historical and ethnographic observations, mathematical descriptions of measurable phenomena, and computational algorithms. Despite its evident importance, the mathematical modeling of science still lacks a unifying framework and a comprehensive research agenda. This book aims to fill this gap, reviewing and describing major threads in the mathematical modeling of science dynamics for a wider academic and professional audience. The model classes presented here cover stochastic and statistical models, game-theoretic approaches, agent-based simulations, population-dy...

K C Kumara Swamy

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. K C Kumara Swamy. Articles written in Resonance – Journal of Science Education. Volume 11 Issue 9 September 2006 pp 72-75 Feature Article. Molecule Matters - A Chromium Compound with a Quintuple Bond · K C Kumara Swamy · More Details Fulltext PDF ...

The Status of Science Education in Illinois Scientific Literacy Target Schools, K-6, 1994. A Study.

Science.gov (United States)

Finson, Kevin D.; Beaver, John B.

The Illinois State Board of Education's Scientific Literacy Project provided extra funds to certain schools with the intent of creating demonstration schools useful as models for other schools to improve their science education programs. The study described in this document examined the impact of these funds on the target schools and attempted to…

The valence state of uranium in K{sub 6}Cu{sub 12}U{sub 2}S{sub 15}

Energy Technology Data Exchange (ETDEWEB)

Schilder, H; Speldrich, M; Lueken, H; Sutorik, A C; Kanatzidis, M G

2004-07-14

The paramagnetic behaviour of K{sub 6}Cu{sub 12}U{sub 2}S{sub 15} has been analysed, regarding copper as diamagnetic (Cu{sup +}), sulfur as mixed-valent S{sup 2-}/S{sup -} with magnetically silent delocalized S{sup -} holes in the valence band, and the actinide as either U{sup 5+}[5f{sup 1}] or U{sup 4+}[5f{sup 2}] in trigonally distorted octahedral surrounding (pseudosymmetry 3-bar) of sulfur. Fitting procedures have been carried out, accounting for spin-orbit coupling, ligand-field potential (parameters B{sup k}{sub q}), interelectronic repulsion (for U{sup 4+}[5f{sup 2}]), cooperative magnetic effects (molecular field parameter {lambda}), and applied magnetic field. Keeping the ratios B{sup 4}{sub 3}/B{sup 4}{sub 0}, B{sup 6}{sub 3}/B{sup 6}{sub 0}, B{sup 6}{sub 6}/B{sup 6}{sub 0} on their point charge electrostatic values with respect to the sulfur ligands, the three axial parameters B{sup k}{sub 0} (k=2,4,6) and {lambda} were refined. Agreement between measured and calculated susceptibility data was obtained for U{sup 5+} with B{sup k}{sub 0} values expected for octahedral surrounding and {lambda}<0 speaking for antiferromagnetic interactions. The U{sup 4+} model does yield a fit of comparable quality, but gives B{sup k}{sub 0} values that are unreasonable with respect to sign and magnitude. To conclude, on the basis of the magnetic properties the title compound is a 5f{sup 1} system corresponding to the elements formal charges (K{sup +}){sub 6}(Cu{sup +}){sub 12}(U{sup 5+}){sub 2}(S{sup 2-}){sub 13}(S{sup -}){sub 2}.

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.

Science.gov (United States)

Smith, Mark A; Katsouri, Loukia; Irvine, Elaine E; Hankir, Mohammed K; Pedroni, Silvia M A; Voshol, Peter J; Gordon, Matthew W; Choudhury, Agharul I; Woods, Angela; Vidal-Puig, Antonio; Carling, David; Withers, Dominic J

2015-04-21

Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic S6K1 signaling on energy homeostasis and the cellular mechanisms underlying these roles are unclear. We therefore inactivated S6K1 in pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, but in contrast to the current view, we found no evidence that S6K1 regulates food intake and bodyweight. In contrast, S6K1 signaling in POMC neurons regulated hepatic glucose production and peripheral lipid metabolism and modulated neuronal excitability. S6K1 signaling in AgRP neurons regulated skeletal muscle insulin sensitivity and was required for glucose sensing by these neurons. Our findings suggest that S6K1 signaling is not a general integrator of energy homeostasis in the mediobasal hypothalamus but has distinct roles in the regulation of glucose homeostasis by POMC and AgRP neurons. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

6th International Conference on Computer Science and its Applications

CERN Document Server

Stojmenovic, Ivan; Jeong, Hwa; Yi, Gangman

2015-01-01

The 6th FTRA International Conference on Computer Science and its Applications (CSA-14) will be held in Guam, USA, Dec. 17 - 19, 2014. CSA-14 presents a comprehensive conference focused on the various aspects of advances in engineering systems in computer science, and applications, including ubiquitous computing, U-Health care system, Big Data, UI/UX for human-centric computing, Computing Service, Bioinformatics and Bio-Inspired Computing and will show recent advances on various aspects of computing technology, Ubiquitous Computing Services and its application.

Framework for Disciplinary Writing in Science Grades 6-12: A National Survey

Science.gov (United States)

Drew, Sally Valentino; Olinghouse, Natalie G.; Faggella-Luby, Michael; Welsh, Megan E.

2017-01-01

This study investigated the current state of writing instruction in science classes (Grades 6-12). A random sample of certified science teachers from the United States (N = 287) was electronically surveyed. Participants reported on their purposes for teaching writing, the writing assignments most often given to students, use of evidence-based…

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. P K Parhi. Articles written in Bulletin of Materials Science. Volume 24 Issue 2 April 2001 pp 143-149. Failure analysis of multiple delaminated composite plates due to bending and impact · P K Parhi S K Bhattacharyya P K Sinha · More Details Abstract Fulltext PDF. The present ...

Phosphotungstic acid binding in situ to K4Nb6O17 for the effective adsorption-photocatalytic removal of tetracycline

Science.gov (United States)

Gu, Huimin; Lang, Junyu; Ma, Yuli; Gu, Huayu; Song, Yanyong; Chai, Zhanli; Li, Guangshe; Wang, Xiaojing

2018-05-01

In this investigation, phosphotungstic acid (H3PW12O40) was successfully self-assembly implanted into the interspace of K4Nb6O17 nanosheet via an impregnation method to form an adsorption-photocatalytic composite, in which n-type semiconductor K4Nb6O17 was selected as photo-electron emitter and H3PW12O40 was particularly used as an electronic transmitter. By characterizing with X-ray diffraction (XRD), transmission (TEM), scan electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and FT-IR spectrum (FT-IR), it confirmed that H3PW12O40 (HPW) was converted to the insoluble tiny particles of K3PW12O40 (KPW) with the remained primary Keggin group via an ion-exchanged H+ of HPW with K+ in K4Nb6O17 in the implanted process and was firmly bound to the surface of K4Nb6O17 to form well sandwich structure. UV-vis diffuse reflectance spectroscopy revealed that the band gap of K4Nb6O17-K3PW12O40 have a slight red shift compared with the single K4Nb6O17. Its adsorption-photocatalytic properties were evaluated with the removal of tetracycline as model reaction. Compared with pure K4Nb6O17, tetracycline removal rate can be significantly improved for the as-prepared sandwich. Importantly, the removal could still maintain 70% after five reuses in recycle tests at an acidic solution, inferring a good stability which was mainly ascribed to the formation of water-insoluble K3PW12O40. The separation and transfer process of photogenerated electrons were investigated by surface photovoltage spectroscopy (SPV). It proposed that the KPW anchored firmly on the interlayers of K4Nb6O17 through a O-K-O bridge plays a significantly role in promoting the separation of the photogenerated carriers and preventing the leakage and agglomeration of HPW. The present results showed that the strategy of the phosphotungstic acid binding in situ to K4Nb6O17 was favorable to promote the hetero-photocatalytic efficiency as well as reusability. [Figure not available: see fulltext.

Dalitz Plot Analysis of the Decay B+ -> K+K+K-

Energy Technology Data Exchange (ETDEWEB)

Dvoretskii, Alexei; /SLAC /Caltech

2006-05-05

The authors perform an analysis of the three-body charmless decay B{sup {+-}} {yields} K{sup {+-}}K{sup {+-}}K{sup {-+}} using a sample of 226.0 {+-} 2.5 million B{bar B} pairs collected by the BABAR detector and measure the total branching fraction and Cp asymmetry to be {beta} = (35.2 {+-} 0.9 {+-} 1.6) x 10{sup -6} and A{sub CP} = (-1.7 {+-} 2.6 {+-} 1.5)%. They fit the Dalitz plot distribution using an isobar model and report the measured values of magnitudes and phases of the production coefficients. The decay dynamics is dominated by the K{sup +}K{sup -} S-wave, for which we perform a partial-wave analysis in the region m(K{sup +}K{sup -}) < 2 GeV/c{sup 2}. They find no evidence of CP violation for individual components of the isobar model.

A J K Prasad

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A J K Prasad. Articles written in Bulletin of Materials Science. Volume 34 Issue 7 December 2011 pp 1339-1344. Synthesis and characterization of mixture of nanozirconia and nanosilica obtained from commercially available zircon flour by sol–gel method · A J K Prasad S M ...

Unravelling pathways downstream Sox6 induction in K562 erythroid cells by proteomic analysis

KAUST Repository

Barbarani, Gloria; Ronchi, Antonella; Ruoppolo, Margherita; Santorelli, Lucia; Steinfelder, Robert; Elangovan, Sudharshan; Fugazza, Cristina; Caterino, Marianna

2017-01-01

are accompanied with a reduced survival of Sox6-/- red blood cells, resulting in a compensated anemia. Sox6-overexpression in K562 cells and in human primary ex vivo erythroid cultures enhances erythroid differentiation and leads to hemoglobinization, the hallmark

Top-down approach to unified supergravity models

International Nuclear Information System (INIS)

Hempfling, R.

1994-03-01

We introduce a new approach for studying unified supergravity models. In this approach all the parameters of the grand unified theory (GUT) are fixed by imposing the corresponding number of low energy observables. This determines the remaining particle spectrum whose dependence on the low energy observables can now be investigated. We also include some SUSY threshold corrections that have previously been neglected. In particular the SUSY threshold corrections to the fermion masses can have a significant impact on the Yukawa coupling unification. (orig.)

Benchmarking and Evaluating Unified Memory for OpenMP GPU Offloading

Energy Technology Data Exchange (ETDEWEB)

Mishra, Alok [Stony Brook Univ., Stony Brook, NY (United States); Li, Lingda [Brookhaven National Lab. (BNL), Upton, NY (United States); Kong, Martin [Brookhaven National Lab. (BNL), Upton, NY (United States); Finkel, Hal [Argonne National Lab. (ANL), Argonne, IL (United States); Chapman, Barbara [Stony Brook Univ., Stony Brook, NY (United States); Brookhaven National Lab. (BNL), Upton, NY (United States)

2017-01-01

Here, the latest OpenMP standard offers automatic device offloading capabilities which facilitate GPU programming. Despite this, there remain many challenges. One of these is the unified memory feature introduced in recent GPUs. GPUs in current and future HPC systems have enhanced support for unified memory space. In such systems, CPU and GPU can access each other's memory transparently, that is, the data movement is managed automatically by the underlying system software and hardware. Memory over subscription is also possible in these systems. However, there is a significant lack of knowledge about how this mechanism will perform, and how programmers should use it. We have modified several benchmarks codes, in the Rodinia benchmark suite, to study the behavior of OpenMP accelerator extensions and have used them to explore the impact of unified memory in an OpenMP context. We moreover modified the open source LLVM compiler to allow OpenMP programs to exploit unified memory. The results of our evaluation reveal that, while the performance of unified memory is comparable with that of normal GPU offloading for benchmarks with little data reuse, it suffers from significant overhead when GPU memory is over subcribed for benchmarks with large amount of data reuse. Based on these results, we provide several guidelines for programmers to achieve better performance with unified memory.

UPQC (Unified power Quality Conditioner)

Indian Academy of Sciences (India)

First page Back Continue Last page Graphics. UPQC (Unified power Quality Conditioner). Hybrid of Shunt and Series compensator. Compensate both Current Quality and Voltage Quality. Costlier Solution as it involves two set of Inverters.

Unified Phase Diagram for Iron-Based Superconductors.

Science.gov (United States)

Gu, Yanhong; Liu, Zhaoyu; Xie, Tao; Zhang, Wenliang; Gong, Dongliang; Hu, Ding; Ma, Xiaoyan; Li, Chunhong; Zhao, Lingxiao; Lin, Lifang; Xu, Zhuang; Tan, Guotai; Chen, Genfu; Meng, Zi Yang; Yang, Yi-Feng; Luo, Huiqian; Li, Shiliang

2017-10-13

High-temperature superconductivity is closely adjacent to a long-range antiferromagnet, which is called a parent compound. In cuprates, all parent compounds are alike and carrier doping leads to superconductivity, so a unified phase diagram can be drawn. However, the properties of parent compounds for iron-based superconductors show significant diversity and both carrier and isovalent dopings can cause superconductivity, which casts doubt on the idea that there exists a unified phase diagram for them. Here we show that the ordered moments in a variety of iron pnictides are inversely proportional to the effective Curie constants of their nematic susceptibility. This unexpected scaling behavior suggests that the magnetic ground states of iron pnictides can be achieved by tuning the strength of nematic fluctuations. Therefore, a unified phase diagram can be established where superconductivity emerges from a hypothetical parent compound with a large ordered moment but weak nematic fluctuations, which suggests that iron-based superconductors are strongly correlated electron systems.

Unified Phase Diagram for Iron-Based Superconductors

Science.gov (United States)

Gu, Yanhong; Liu, Zhaoyu; Xie, Tao; Zhang, Wenliang; Gong, Dongliang; Hu, Ding; Ma, Xiaoyan; Li, Chunhong; Zhao, Lingxiao; Lin, Lifang; Xu, Zhuang; Tan, Guotai; Chen, Genfu; Meng, Zi Yang; Yang, Yi-feng; Luo, Huiqian; Li, Shiliang

2017-10-01

High-temperature superconductivity is closely adjacent to a long-range antiferromagnet, which is called a parent compound. In cuprates, all parent compounds are alike and carrier doping leads to superconductivity, so a unified phase diagram can be drawn. However, the properties of parent compounds for iron-based superconductors show significant diversity and both carrier and isovalent dopings can cause superconductivity, which casts doubt on the idea that there exists a unified phase diagram for them. Here we show that the ordered moments in a variety of iron pnictides are inversely proportional to the effective Curie constants of their nematic susceptibility. This unexpected scaling behavior suggests that the magnetic ground states of iron pnictides can be achieved by tuning the strength of nematic fluctuations. Therefore, a unified phase diagram can be established where superconductivity emerges from a hypothetical parent compound with a large ordered moment but weak nematic fluctuations, which suggests that iron-based superconductors are strongly correlated electron systems.

ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum.

Science.gov (United States)

Fülöp, Krisztina; Jiang, Qiujie; Wetering, Koen V D; Pomozi, Viola; Szabó, Pál T; Arányi, Tamás; Sarkadi, Balázs; Borst, Piet; Uitto, Jouni; Váradi, András

2011-11-25

Vitamin K is a cofactor required for gamma-glutamyl carboxylation of several proteins regulating blood clotting, bone formation and soft tissue mineralization. Vitamin K3 is an important intermediate during conversion of the dietary vitamin K1 to the most abundant vitamin K2 form. It has been suggested that ABCC6 may have a role in transporting vitamin K or its derivatives from the liver to the periphery. This activity is missing in pseudoxanthoma elasticum, a genetic disorder caused by mutations in ABCC6 characterized by abnormal soft tissue mineralization. Here we examined the efflux of the glutathione conjugate of vitamin K3 (VK3GS) from the liver in wild type and Abcc6(-/-) mice, and in transport assays in vitro. We found in liver perfusion experiments that VK3GS is secreted into the inferior vena cava, but we observed no significant difference between wild type and Abcc6(-/-) animals. We overexpressed the human ABCC6 transporter in Sf9 insect and MDCKII cells and assayed its vitamin K3-conjugate transport activity in vitro. We found no measurable transport of VK3GS by ABCC6, whereas ABCC1 transported this compound at high rate in these assays. These results show that VK3GS is not the essential metabolite transported by ABCC6 from the liver and preventing the symptoms of pseudoxanthoma elasticum. Copyright © 2011 Elsevier Inc. All rights reserved.

Tables of the 3-j, 6-j, Fsub(k)-, Asub(k)-, Rsub(k)-, and Asub(kk)-coefficients for angular correlation measurements involving half integer spins up to 15/2 and transitions up to L = 3

International Nuclear Information System (INIS)

Gueven, H.H.; Kardon, B.; Seyfarth, H.

1975-07-01

Theoretical directional correlation coefficiencts are given as 3-j, 6-j, Fsub(k), Asub(k), Rsub(k) and Asub(kk) coefficients for half integer spins up to 15/2 and for transitions up to L = 3. (WL) [de

Unravelling pathways downstream Sox6 induction in K562 erythroid cells by proteomic analysis

KAUST Repository

Barbarani, Gloria

2017-10-20

The Sox6 transcription factor is crucial for terminal maturation of definitive red blood cells. Sox6-null mouse fetuses present misshapen and nucleated erythrocytes, due to impaired actin assembly and cytoskeleton stability. These defects are accompanied with a reduced survival of Sox6-/- red blood cells, resulting in a compensated anemia. Sox6-overexpression in K562 cells and in human primary ex vivo erythroid cultures enhances erythroid differentiation and leads to hemoglobinization, the hallmark of erythroid maturation. To obtain an overview on processes downstream to Sox6 expression, we performed a differential proteomic analysis on human erythroid K562 cells overexpressing Sox6. Sox6-overexpression induces dysregulation of 64 proteins, involved in cytoskeleton remodeling and in protein synthesis, folding and trafficking, key processes for erythroid maturation. Moreover, 43 out of 64 genes encoding for differentially expressed proteins contain within their proximal regulatory regions sites that are bound by SOX6 according to ENCODE ChIP-seq datasets and are possible direct SOX6 targets. SAR1B, one of the most induced proteins upon Sox6 overexpression, shares a conserved regulatory module, composed by a double SOX6 binding site and a GATA1 consensus, with the adjacent SEC24 A gene. Since both genes encode for COPII components, this element could concur to the coordinated expression of these proteins during erythropoiesis.

Synthesis, crystal structure and characterizations of a new red phosphor K{sub 3}EuB{sub 6}O{sub 12}

Energy Technology Data Exchange (ETDEWEB)

Zhao, Dan, E-mail: iamzd1996@163.com [College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan, 454000 (China); State Key Laboratory of Structural Chemistry, Fuzhou, Fujian, 350002 (China); Ma, Fa-Xue; Wu, Zhi-Qiang; Zhang, Lei [College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan, 454000 (China); Wei, Wei, E-mail: wwei@cnu.edu.cn [Department of Chemistry, Capital Normal University, Beijing, 100048 (China); Yang, Juan; Zhang, Rong-Hua; Chen, Peng-Fei; Wu, Shan-Xuan [College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan, 454000 (China)

2016-10-01

A new potassium europium borate K{sub 3}EuB{sub 6}O{sub 12} has been prepared using a high temperature molten salt method and structurally characterized by single crystal X-ray diffraction (SC-XRD) analyses. Its structure features a three-dimensional (3D) framework composed of isolated [B{sub 5}O{sub 10}]{sup 5−} anions that are bridged by K{sup +} and Eu{sup 3+} ions. In this structure, one crystallographic distinct atom site is mixed occupied by K/Eu at a molar ratio of 1:1. The self-activated photoluminescence (PL) of K{sub 3}EuB{sub 6}O{sub 12} was studied. The excitation spectrum covers a wide range from 322 to 466 nm, which suggests that the K{sub 3}EuB{sub 6}O{sub 12} phosphors can be effectively excited by a near-UV light source. The emission spectrum consists of groups of lines in the red spectral region due to the {sup 5}D{sub 0}→{sup 7}F{sub j} (j = 1, 2, 3, 4) electronic transitions of Eu{sup 3+} ions, with the most intense line at 611 nm. We may expect that K{sub 3}EuB{sub 6}O{sub 12} has the potential to be a red phosphor pumped by near-UV LED chips. - Highlights: • A new red phosphor K{sub 3}EuB{sub 6}O{sub 12} was prepared. • The crystal structure of K{sub 3}EuB{sub 6}O{sub 12} was determined for the first time. • The photoluminescence properties of K{sub 3}EuB{sub 6}O{sub 12} are studied. • K{sub 3}EuB{sub 6}O{sub 12} show intense self-activated red emission under near-UV light excitation.

Perturbation to Unified Symmetry and Adiabatic Invariants for Relativistic Hamilton Systems

International Nuclear Information System (INIS)

Zhang Mingjiang; Fang Jianhui; Lu Kai; Pang Ting; Lin Peng

2009-01-01

Based on the concept of adiabatic invariant, the perturbation to unified symmetry and adiabatic invariants for relativistic Hamilton systems are studied. The definition of the perturbation to unified symmetry for the system is presented, and the criterion of the perturbation to unified symmetry is given. Meanwhile, the Noether adiabatic invariants, the generalized Hojman adiabatic invariants, and the Mei adiabatic invariants for the perturbed system are obtained. (general)

TNP [N2-(m-Trifluorobenzyl, N6-(p-nitrobenzylpurine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Directory of Open Access Journals (Sweden)

Sarbani Ghoshal

2016-10-01

Full Text Available Objective: Obesity and type 2 diabetes (T2D lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can be targeted in obesity/T2D. Deletion of the inositol pyrophosphate (5-IP7 biosynthetic enzyme, inositol hexakisphosphate kinase-1 (IP6K1, protects mice from high fat diet (HFD induced obesity (DIO and insulin resistance. Yet, whether this pathway is a valid pharmacologic target in obesity/T2D is not known. Here, we demonstrate that TNP [N2-(m-Trifluorobenzyl, N6-(p-nitrobenzylpurine], a pan-IP6K inhibitor, has strong anti-obesity and anti-diabetic effects in DIO mice. Methods: Q-NMR, GTT, ITT, food intake, energy expenditure, QRT-PCR, ELISA, histology, and immunoblot studies were conducted in short (2.5-week- and long (10-week-term TNP treated DIO C57/BL6 WT and IP6K1-KO mice, under various diet and temperature conditions. Results: TNP, when injected at the onset of HFD-feeding, decelerates initiation of DIO and insulin resistance. Moreover, TNP facilitates weight loss and restores metabolic parameters, when given to DIO mice. However, TNP does not reduce weight gain in HFD-fed IP6K1-KO mice. TNP specifically enhances insulin sensitivity in DIO mice via Akt activation. TNP decelerates weight gain primarily by enhancing thermogenic energy expenditure in the adipose tissue. Accordingly, TNP's effect on body weight is partly abolished whereas its impact on glucose homeostasis is preserved at thermoneutral temperature. Conclusion: Pharmacologic inhibition of the inositol pyrophosphate pathway has strong therapeutic potential in obesity, T2D, and other metabolic diseases. Author Video: Author Video Watch what authors say about their articles Keywords: IP6K, Inositol pyrophosphate, Obesity, Energy expenditure, Diabetes, Akt

250 kV 6 mA compact Cockcroft-Walton high-voltage power supply

Energy Technology Data Exchange (ETDEWEB)

Ma, Zhan-Wen; Su, Xiao-Dong; Wei, Zhen; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Lu, Xiao-Long; Wang, Jun-Run; Yao, Ze-En, E-mail: zeyao@lzu.edu.cn [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China)

2016-08-15

A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

Synchronization of a unified chaotic system and the application in secure communication

International Nuclear Information System (INIS)

Lu Junan; Wu Xiaoqun; Lue Jinhu

2002-01-01

This Letter further investigates the synchronization of a unified chaotic system via different methods. Several sufficient theorems for the synchronization of the unified chaotic system are deduced. A scheme of secure communication based on the synchronization of the unified chaotic system is presented. Numerical simulation shows its feasibility

Controllable solvothermal synthesis and photocatalytic properties of complex (oxy)fluorides K{sub 2}TiOF{sub 4}, K{sub 3}TiOF{sub 5}, K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} and K{sub 2}TiF{sub 6}

Energy Technology Data Exchange (ETDEWEB)

Sheng Jie [Division of Nanomaterials and Nanochemistry, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230026 (China); Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China); Tang Kaibin, E-mail: kbtang@ustc.edu.cn [Division of Nanomaterials and Nanochemistry, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230026 (China); Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China); Cheng Wei; Wang Junli; Nie Yanxiang; Yang Qing [Division of Nanomaterials and Nanochemistry, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230026 (China); Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China)

2009-11-15

Complex (oxy)fluorides K{sub 2}TiF{sub 6}, K{sub 2}TiOF{sub 4}, K{sub 3}TiOF{sub 5} and K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} have been successfully synthesized for the first time through a controllable solvothermal route involving different solvents, for example, methanol, methanol-H{sub 2}O and methanol-H{sub 2}O{sub 2}. The as-prepared products were characterized by X-ray powder diffraction, N{sub 2} surface area adsorption, scanning electron microscope, Fourier transform infrared spectroscopy, UV-vis absorption spectra and X-ray fluorescence. The influences of reaction conditions such as the ratio of methanol to H{sub 2}O{sub 2} or methanol to H{sub 2}O, reaction temperature on the phase, crystallizability and purity of the (oxy)fluorides products were discussed in detail. Meanwhile, the photocatalytic behaviors of the as-prepared K{sub 2}TiF{sub 6}, K{sub 2}TiOF{sub 4}, K{sub 3}TiOF{sub 5} and K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} were evaluated by degradation of rhodamine B molecules, and the results showed that all of the products possessed photocatalytic activities in the order of K{sub 2}TiOF{sub 4} > K{sub 2}TiF{sub 6} > K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} > K{sub 3}TiOF{sub 5} at room temperature under the UV light.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. V D Mishra. Articles written in Journal of Earth System Science. Volume 118 Issue 1 February 2009 pp 11-26. Assessment of different topographic corrections in AWiFS satellite imagery of Himalaya terrain · V D Mishra J K Sharma K K Singh N K Thakur M Kumar.

Conceptualising paediatric health disparities: a metanarrative systematic review and unified conceptual framework.

Science.gov (United States)

Ridgeway, Jennifer L; Wang, Zhen; Finney Rutten, Lila J; van Ryn, Michelle; Griffin, Joan M; Murad, M Hassan; Asiedu, Gladys B; Egginton, Jason S; Beebe, Timothy J

2017-08-04

There exists a paucity of work in the development and testing of theoretical models specific to childhood health disparities even though they have been linked to the prevalence of adult health disparities including high rates of chronic disease. We conducted a systematic review and thematic analysis of existing models of health disparities specific to children to inform development of a unified conceptual framework. We systematically reviewed articles reporting theoretical or explanatory models of disparities on a range of outcomes related to child health. We searched Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus (database inception to 9 July 2015). A metanarrative approach guided the analysis process. A total of 48 studies presenting 48 models were included. This systematic review found multiple models but no consensus on one approach. However, we did discover a fair amount of overlap, such that the 48 models reviewed converged into the unified conceptual framework. The majority of models included factors in three domains: individual characteristics and behaviours (88%), healthcare providers and systems (63%), and environment/community (56%), . Only 38% of models included factors in the health and public policies domain. A disease-agnostic unified conceptual framework may inform integration of existing knowledge of child health disparities and guide future research. This multilevel framework can focus attention among clinical, basic and social science research on the relationships between policy, social factors, health systems and the physical environment that impact children's health outcomes. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation

Directory of Open Access Journals (Sweden)

MacKenzie Matthew G

2010-05-01

Full Text Available Abstract Background Myogenesis in C2C12 cells requires the activation of the PI3K/mTOR signaling pathways. Since mTOR signaling can feedback through S6K1 to inhibit the activation of PI3K, the aim of this work was to assess whether feedback from S6K1 played a role in myogenesis and determine whether siRNA mediated knockdown of S6K1 would lead to an increased rate of myotube formation. Results S6K1 activity increased in a linear fashion following plating and was more than 3-fold higher after Day 3 of differentiation (subconfluent = 11.09 ± 3.05, Day 3 = 29.34 ± 3.58. IRS-1 levels tended to increase upon serum withdrawal but decreased approximately 2-fold (subconfluent = 0.88 ± 0.10, Day 3 = 0.42 ± 0.06 3 days following differentiation whereas IRS-2 protein remained stable. IRS-1 associated p85 was significantly reduced upon serum withdrawal (subconfluent = 0.86 ± 0.07, Day 0 = 0.31 ± 0.05, remaining low through day 1. IRS-2 associated p85 decreased following serum withdrawal (subconfluent = 0.96 ± 0.05, Day 1 = 0.56 ± 0.08 and remained suppressed up to Day 3 following differentiation (0.56 ± 0.05. Phospho-tyrosine associated p85 increased significantly from subconfluent to Day 0 and remained elevated throughout differentiation. siRNA directed against S6K1 and S6K2 did not result in changes in IRS-1 levels after either 48 or 96 hrs. Furthermore, neither 48 nor 96 hrs of S6K1 knockdown caused a change in myotube formation. Conclusions Even though S6K1 activity increases throughout muscle cell differentiation and IRS-1 levels decrease over this period, siRNA suggests that S6K1 is not mediating the decrease in IRS-1. The decrease in IRS-1/2 associated p85 together with the increase in phospho-tyrosine associated p85 suggests that PI3K associates primarily with scaffolds other than IRS-1/2 during muscle cell differentiation.

Science Inquiry into Local Animals: Structure and Function Explored through Model Making

Science.gov (United States)

Rule, Audrey C.; Tallakson, Denise A.; Glascock, Alex L.; Chao, Astoria

2015-01-01

This article describes an arts- and spatial thinking skill--integrated inquiry project applied to life science concepts from the Next Generation Science Standards for fourth grade students that focuses on two unifying or crosscutting themes: (1) structure (or "form") and function and (2) use of models. Students made observations and…

A K-theory anomaly free supersymmetric flipped SU(5) model from intersecting branes

Energy Technology Data Exchange (ETDEWEB)

Chen, C.-M. [George P. and Cynthia W. Mitchell Institute for Fundamental Physics, Texas A and M University, College Station, TX 77843 (United States)]. E-mail: cchen@physics.tamu.edu; Kraniotis, G.V. [George P. and Cynthia W. Mitchell Institute for Fundamental Physics, Texas A and M University, College Station, TX 77843 (United States)]. E-mail: kraniotis@physics.tamu.edu; Mayes, V.E. [George P. and Cynthia W. Mitchell Institute for Fundamental Physics, Texas A and M University, College Station, TX 77843 (United States)]. E-mail: eric@physics.tamu.edu; Nanopoulos, D.V. [George P. and Cynthia W. Mitchell Institute for Fundamental Physics, Texas A and M University, College Station, TX 77843 (United States) and Astroparticle Physics Group, Houston Advanced Research Center (HARC), Mitchell Campus, Woodlands, TX 77381 (United States) and Academy of Athens, Division of Natural Sciences, 28 Panepistimiou Avenue, Athens 10679 (Greece)]. E-mail: dimitri@physics.tamu.edu; Walker, J.W. [George P. and Cynthia W. Mitchell Institute for Fundamental Physics, Texas A and M University, College Station, TX 77843 (United States)]. E-mail: jwalker@physics.tamu.edu

2005-10-06

We construct an N=1 supersymmetric three-family flipped SU(5) model from type IIA orientifolds on T{sup 6}/(Z{sub 2}xZ{sub 2}) with D6-branes intersecting at general angles. The model is constrained by the requirement that Ramond-Ramond tadpoles cancel, the supersymmetry conditions, and that the gauge boson coupled to the U(1){sub X} factor does not get a string-scale mass via a generalised Green-Schwarz mechanism. The model is further constrained by requiring cancellation of K-theory charges. The spectrum contains a complete grand unified and electroweak Higgs sector, however the latter in a non-minimal number of copies. In addition, it contains extra matter both in bi-fundamental and vector-like representations as well as two copies of matter in the symmetric representation of SU(5)

How to Implement Rigorous Computer Science Education in K-12 Schools? Some Answers and Many Questions

Science.gov (United States)

Hubwieser, Peter; Armoni, Michal; Giannakos, Michail N.

2015-01-01

Aiming to collect various concepts, approaches, and strategies for improving computer science education in K-12 schools, we edited this second special issue of the "ACM TOCE" journal. Our intention was to collect a set of case studies from different countries that would describe all relevant aspects of specific implementations of…

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. K K Osuri. Articles written in Journal of Earth System Science. Volume 125 Issue 3 April 2016 pp 475-498. Role of land state in a high resolution mesoscale model for simulating the Uttarakhand heavy rainfall event over India · P V Rajesh S Pattnaik D Rai K K Osuri U C ...

A model of unified quantum chromodynamics and Yang-Mills gravity

International Nuclear Information System (INIS)

HSU Jongping

2012-01-01

Based on a generalized Yang-Mills framework, gravitational and strong interactions can be unified in analogy with the unification in the electroweak theory. By gauging T(4) × [SU(3)] color in flat space-time, we have a unified model of chromo-gravity with a new tensor gauge field, which couples universally to all gluons, quarks and anti-quarks. The space-time translational gauge symmetry assures that all wave equations of quarks and gluons reduce to a Hamilton-Jacobi equation with the same 'effective Riemann metric tensors’ in the geometric-optics (or classical) limit. The emergence of effective metric tensors in the classical limit is essential for the unified model to agree with experiments. The unified model suggests that all gravitational, strong and electroweak interactions appear to be dictated by gauge symmetries in the generalized Yang-Mills framework. (author)

A model of unified quantum chromodynamics and Yang-Mills gravity

Institute of Scientific and Technical Information of China (English)

HSU Jong-Ping

2012-01-01

Based on a generalized Yang-Mills framework,gravitational and strong interactions can be unified in analogy with the unification in the clectroweak theory.By gauging T(4) × [SU(3)]color in fiat space-time,we have a unified model of chromo-gravity with a new tensor gauge field,which couples universally to all gluons,quarks and anti-quarks.The space-time translational gauge symmetry assures that all wave equations of quarks and gluons reduce to a Hamilton-Jacobi equation with the same ‘effective Riemann metric tensors' in the geometric-optics (or classical) limit.The emergence of effective metric tensors in the classical limit is essential for the unified model to agree with experiments.The unified model suggests that all gravitational,strong and electroweak interactions appear to be dictated by gauge symmetries in the generalized Yang-Mills framework.

Unifying distribution functions: some lesser known distributions.

Science.gov (United States)

Moya-Cessa, J R; Moya-Cessa, H; Berriel-Valdos, L R; Aguilar-Loreto, O; Barberis-Blostein, P

2008-08-01

We show that there is a way to unify distribution functions that describe simultaneously a classical signal in space and (spatial) frequency and position and momentum for a quantum system. Probably the most well known of them is the Wigner distribution function. We show how to unify functions of the Cohen class, Rihaczek's complex energy function, and Husimi and Glauber-Sudarshan distribution functions. We do this by showing how they may be obtained from ordered forms of creation and annihilation operators and by obtaining them in terms of expectation values in different eigenbases.

Coral Reef and Hardbottom from Unified Florida Reef Tract Map (NODC Accession 0123059)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Coral reef and Hardbottom areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. K Senthil Kumar. Articles written in Journal of Chemical Sciences. Volume 114 Issue 4 August 2002 pp 367-377. Chemistry of selected cyclic P(III) compounds possessing a P-Cl bond · K C Kumara Swamy Sudha Kumaraswamy Praveen Kommana N Satish Kumar K Senthil ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2007-08-06

Aug 6, 2007 ... Author Affiliations. Pawan K Dhar1. Synthetic Genomics, Systems Biology Group, E209, RIKEN Genomic Sciences Centre, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan ...